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Search of human proteins with 38569457
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38569457 solute carrier family 12, member 8 [Homo sapiens]
(714 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38569457 solute carrier family 12, member 8 [Homo sapiens] 1426 0.0
gi|4506975 solute carrier family 12 (sodium/potassium/chloride t... 254 1e-67
gi|134254459 sodium potassium chloride cotransporter 2 [Homo sap... 245 9e-65
gi|186910319 solute carrier family 12, member 3 isoform 3 [Homo ... 224 2e-58
gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo ... 224 2e-58
gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo ... 224 2e-58
gi|31881740 solute carrier family 12 (potassium/chloride transpo... 185 1e-46
gi|110224458 solute carrier family 12, member 6 isoform e [Homo ... 104 2e-22
gi|110224456 solute carrier family 12, member 6 isoform d [Homo ... 104 2e-22
gi|110224454 solute carrier family 12, member 6 isoform c [Homo ... 104 2e-22
gi|110224452 solute carrier family 12, member 6 isoform c [Homo ... 104 2e-22
gi|4826780 solute carrier family 12, member 6 isoform b [Homo sa... 104 2e-22
gi|110224449 solute carrier family 12, member 6 isoform a [Homo ... 104 2e-22
gi|225579067 solute carrier family 12, member 4 isoform e [Homo ... 102 2e-21
gi|225579065 solute carrier family 12, member 4 isoform d [Homo ... 102 2e-21
gi|225579063 solute carrier family 12, member 4 isoform c [Homo ... 102 2e-21
gi|225579061 solute carrier family 12, member 4 isoform b [Homo ... 102 2e-21
gi|4827006 solute carrier family 12, member 4 isoform a [Homo sa... 102 2e-21
gi|123701900 solute carrier family 12 (potassium/chloride transp... 102 2e-21
gi|198041678 solute carrier family 12 (potassium-chloride transp... 100 5e-21
gi|11968148 solute carrier family 12 (potassium-chloride transpo... 100 5e-21
gi|4507047 solute carrier family 7 (cationic amino acid transpor... 59 1e-08
gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo s... 57 5e-08
gi|33286428 solute carrier family 7 (cationic amino acid transpo... 52 1e-06
gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo s... 49 2e-05
gi|114326550 solute carrier family 7 (cationic amino acid transp... 44 4e-04
gi|114326544 solute carrier family 7 (cationic amino acid transp... 44 4e-04
gi|9790235 solute carrier family 7, member 10 [Homo sapiens] 41 0.003
gi|54112380 F-box and leucine-rich repeat protein 10 isoform b [... 38 0.029
gi|7657683 solute carrier family 7, (cationic amino acid transpo... 37 0.049
>gi|38569457 solute carrier family 12, member 8 [Homo sapiens]
Length = 714
Score = 1426 bits (3692), Expect = 0.0
Identities = 714/714 (100%), Positives = 714/714 (100%)
Query: 1 MTQMSQVQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFL 60
MTQMSQVQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFL
Sbjct: 1 MTQMSQVQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFL 60
Query: 61 RTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGG 120
RTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGG
Sbjct: 61 RTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGG 120
Query: 121 TIGLLYVFGQCVAGAMYITGFAESISDLLGLGNIWAVRGISVAVLLALLGINLAGVKWII 180
TIGLLYVFGQCVAGAMYITGFAESISDLLGLGNIWAVRGISVAVLLALLGINLAGVKWII
Sbjct: 121 TIGLLYVFGQCVAGAMYITGFAESISDLLGLGNIWAVRGISVAVLLALLGINLAGVKWII 180
Query: 181 RLQLLLLFLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVF 240
RLQLLLLFLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVF
Sbjct: 181 RLQLLLLFLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVF 240
Query: 241 FPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREALRYDFL 300
FPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREALRYDFL
Sbjct: 241 FPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREALRYDFL 300
Query: 301 IAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTP 360
IAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTP
Sbjct: 301 IAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTP 360
Query: 361 VAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVL 420
VAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVL
Sbjct: 361 VAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVL 420
Query: 421 REGAEGLHCSEHLLLEKAPSYGSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQG 480
REGAEGLHCSEHLLLEKAPSYGSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQG
Sbjct: 421 REGAEGLHCSEHLLLEKAPSYGSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQG 480
Query: 481 EGNRTPESQKRKSKKATKQTLQDSFLLDLKSPPSFPVEISDRLPAASWEGQESCWNKQTS 540
EGNRTPESQKRKSKKATKQTLQDSFLLDLKSPPSFPVEISDRLPAASWEGQESCWNKQTS
Sbjct: 481 EGNRTPESQKRKSKKATKQTLQDSFLLDLKSPPSFPVEISDRLPAASWEGQESCWNKQTS 540
Query: 541 KSEGTQPEGTYGEQLVPELCNQSESSGEDFFLKSRLQEQDVWRRSTSFYTHMCNPWVSLL 600
KSEGTQPEGTYGEQLVPELCNQSESSGEDFFLKSRLQEQDVWRRSTSFYTHMCNPWVSLL
Sbjct: 541 KSEGTQPEGTYGEQLVPELCNQSESSGEDFFLKSRLQEQDVWRRSTSFYTHMCNPWVSLL 600
Query: 601 GAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLGSASNFSFFRWMRSLLLPSC 660
GAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLGSASNFSFFRWMRSLLLPSC
Sbjct: 601 GAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLGSASNFSFFRWMRSLLLPSC 660
Query: 661 RSLRSPQEQIILAPSLAKVDMEMTQLTQENADFATRDRYHHSSLVNREQLMPHY 714
RSLRSPQEQIILAPSLAKVDMEMTQLTQENADFATRDRYHHSSLVNREQLMPHY
Sbjct: 661 RSLRSPQEQIILAPSLAKVDMEMTQLTQENADFATRDRYHHSSLVNREQLMPHY 714
>gi|4506975 solute carrier family 12 (sodium/potassium/chloride
transporters), member 2 [Homo sapiens]
Length = 1212
Score = 254 bits (650), Expect = 1e-67
Identities = 139/416 (33%), Positives = 226/416 (54%), Gaps = 45/416 (10%)
Query: 37 VLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVG 96
V FG GV CM+NI+GV+LF+R W+VG G+ L + ++ +V +T LS +
Sbjct: 283 VKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIA 342
Query: 97 ERSSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLLG------ 150
+ GG Y +IS LG + GG IGL++ F VA AMY+ GFAE++ +LL
Sbjct: 343 TNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILM 402
Query: 151 LGNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVGSFTHLDPE-- 208
+ I +R I ++ LLGI++AG++W + Q++LL +L ++ DFV+G+F L+ +
Sbjct: 403 IDEINDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIPLESKKP 462
Query: 209 HGFIGYSPELLQNNTLPDYSPGESFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGS 268
GF GY E+ N PD+ E+FF+VF +FFPAATG++AG N+ GDL +P ++IP G+
Sbjct: 463 KGFFGYKSEIFNENFGPDFREEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGT 522
Query: 269 LAAVGISWFLYIVFVFLLGAICTREA---------------------LRYDFLIAEK--- 304
L A+ I+ +Y+ +G+ R+A L +DF E
Sbjct: 523 LLAILITTLVYVGIAVSVGSCVVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPC 582
Query: 305 -------------VSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLG 351
VS L G++ ++L+S + L AP+I Q + ++ + PA
Sbjct: 583 SYGLMNNFQVMSMVSGFTPLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFA 642
Query: 352 QGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSM 407
+G G N P+ LT L+ + F+ + ++NV+API++ F+ +Y +++S F S+
Sbjct: 643 KGYGKNNEPLRGYILTFLIALGFILIAELNVIAPIISNFFLASYALINFSVFHASL 698
Score = 45.1 bits (105), Expect = 2e-04
Identities = 21/63 (33%), Positives = 35/63 (55%), Gaps = 4/63 (6%)
Query: 582 WRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLG 641
WR + +Y N W+SLLGA+ ++MFVI W L+ + +Y Y+ P ++ G
Sbjct: 704 WRPAFKYY----NMWISLLGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWG 759
Query: 642 SAS 644
S++
Sbjct: 760 SST 762
>gi|134254459 sodium potassium chloride cotransporter 2 [Homo
sapiens]
Length = 1099
Score = 245 bits (626), Expect = 9e-65
Identities = 137/416 (32%), Positives = 220/416 (52%), Gaps = 46/416 (11%)
Query: 37 VLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVG 96
V FG GV CM+NI+GV+LF+R W+VG G+ LG+ ++ +V +T LS +
Sbjct: 175 VKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIA 234
Query: 97 ERSSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLLGLGNIWA 156
+ GG Y +IS LG + GG+IGL++ F VA AMY+ GFAE++ DLL +
Sbjct: 235 TNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMM 294
Query: 157 V------RGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVGSFTHLDPE-- 208
V R I ++ LLGI++AG++W + Q++LL +L ++ +F +G+ + E
Sbjct: 295 VDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKK 354
Query: 209 -HGFIGYSPELLQNNTLPDYSPGESFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLG 267
GF Y + N P ++ GE FF+VF +FFPAATG++AG N+ GDL +P +IP G
Sbjct: 355 SRGFFNYQASIFAENFGPRFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRG 414
Query: 268 SLAAVGISWFLYIVFVFLLGAICTREA---------------------LRYD-------- 298
++ A+ I+ Y+ +GA R+A L YD
Sbjct: 415 TMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEP 474
Query: 299 --------FLIAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACL 350
F + VS G L G++ ++L+S + L AP++ Q + ++ + AL
Sbjct: 475 CQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFF 534
Query: 351 GQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLS 406
+G G N P+ LT L+ MAF+ + ++N +API++ F+ +Y +++S F S
Sbjct: 535 AKGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHAS 590
Score = 41.6 bits (96), Expect = 0.003
Identities = 21/63 (33%), Positives = 32/63 (50%), Gaps = 4/63 (6%)
Query: 582 WRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLG 641
WR + Y N WVSL GAV +MFVI W ++ + +Y Y+ P ++ G
Sbjct: 597 WRPAYGIY----NMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWG 652
Query: 642 SAS 644
S++
Sbjct: 653 SST 655
>gi|186910319 solute carrier family 12, member 3 isoform 3 [Homo
sapiens]
Length = 1021
Score = 224 bits (572), Expect = 2e-58
Identities = 129/421 (30%), Positives = 217/421 (51%), Gaps = 48/421 (11%)
Query: 35 EPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIG 94
EPV FG GV CM+NI+GV+L+LR W+ G++L ++ + V +T LS
Sbjct: 132 EPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISA 191
Query: 95 VGERSSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLLG---- 150
+ + SGG Y +IS LG + GG+IGL++ F V AM+ GFAE++ DLL
Sbjct: 192 ISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGA 251
Query: 151 --LGNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVGSF---THL 205
+ I +R I V + LL I+LAG++W + Q+L ++ VS +++VG+ +
Sbjct: 252 PIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSED 311
Query: 206 DPEHGFIGYSPELLQNNTLPDY-SPGESFFTVFGVFFPAATGVMAGFNMGGDLREPAASI 264
GF Y ++ N +PD+ P +FF +F +FFP+ATG++AG N+ GDL++PA +I
Sbjct: 312 KASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAI 371
Query: 265 PLGSLAAVGISWFLYIVFVFLLGAICTRE-------------------ALRYDFLIAE-- 303
P G+L A+ + Y+ +G+ R+ A Y + E
Sbjct: 372 PKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLACSYGWNFTECT 431
Query: 304 -----------------KVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPA 346
VS L G++ ++L+S + L A ++ QC+ ++++ P
Sbjct: 432 QQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPL 491
Query: 347 LACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLS 406
+ G+G G NK PV L + +AF+ + ++N +API++ F+ +Y +++S F S
Sbjct: 492 IGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHAS 551
Query: 407 M 407
+
Sbjct: 552 I 552
Score = 44.7 bits (104), Expect = 3e-04
Identities = 21/62 (33%), Positives = 35/62 (56%), Gaps = 4/62 (6%)
Query: 582 WRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLG 641
WR S +Y N W +L GA+ S++IMF++ W L+ +GV + Y+ P ++ G
Sbjct: 558 WRPSFQYY----NKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWG 613
Query: 642 SA 643
S+
Sbjct: 614 SS 615
>gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo
sapiens]
Length = 1029
Score = 224 bits (572), Expect = 2e-58
Identities = 129/421 (30%), Positives = 217/421 (51%), Gaps = 48/421 (11%)
Query: 35 EPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIG 94
EPV FG GV CM+NI+GV+L+LR W+ G++L ++ + V +T LS
Sbjct: 131 EPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISA 190
Query: 95 VGERSSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLLG---- 150
+ + SGG Y +IS LG + GG+IGL++ F V AM+ GFAE++ DLL
Sbjct: 191 ISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGA 250
Query: 151 --LGNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVGSF---THL 205
+ I +R I V + LL I+LAG++W + Q+L ++ VS +++VG+ +
Sbjct: 251 PIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSED 310
Query: 206 DPEHGFIGYSPELLQNNTLPDY-SPGESFFTVFGVFFPAATGVMAGFNMGGDLREPAASI 264
GF Y ++ N +PD+ P +FF +F +FFP+ATG++AG N+ GDL++PA +I
Sbjct: 311 KASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAI 370
Query: 265 PLGSLAAVGISWFLYIVFVFLLGAICTRE-------------------ALRYDFLIAE-- 303
P G+L A+ + Y+ +G+ R+ A Y + E
Sbjct: 371 PKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLACSYGWNFTECT 430
Query: 304 -----------------KVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPA 346
VS L G++ ++L+S + L A ++ QC+ ++++ P
Sbjct: 431 QQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPL 490
Query: 347 LACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLS 406
+ G+G G NK PV L + +AF+ + ++N +API++ F+ +Y +++S F S
Sbjct: 491 IGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHAS 550
Query: 407 M 407
+
Sbjct: 551 I 551
Score = 44.7 bits (104), Expect = 3e-04
Identities = 21/62 (33%), Positives = 35/62 (56%), Gaps = 4/62 (6%)
Query: 582 WRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLG 641
WR S +Y N W +L GA+ S++IMF++ W L+ +GV + Y+ P ++ G
Sbjct: 557 WRPSFQYY----NKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWG 612
Query: 642 SA 643
S+
Sbjct: 613 SS 614
>gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo
sapiens]
Length = 1030
Score = 224 bits (572), Expect = 2e-58
Identities = 129/421 (30%), Positives = 217/421 (51%), Gaps = 48/421 (11%)
Query: 35 EPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIG 94
EPV FG GV CM+NI+GV+L+LR W+ G++L ++ + V +T LS
Sbjct: 132 EPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISA 191
Query: 95 VGERSSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLLG---- 150
+ + SGG Y +IS LG + GG+IGL++ F V AM+ GFAE++ DLL
Sbjct: 192 ISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGA 251
Query: 151 --LGNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVGSF---THL 205
+ I +R I V + LL I+LAG++W + Q+L ++ VS +++VG+ +
Sbjct: 252 PIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSED 311
Query: 206 DPEHGFIGYSPELLQNNTLPDY-SPGESFFTVFGVFFPAATGVMAGFNMGGDLREPAASI 264
GF Y ++ N +PD+ P +FF +F +FFP+ATG++AG N+ GDL++PA +I
Sbjct: 312 KASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAI 371
Query: 265 PLGSLAAVGISWFLYIVFVFLLGAICTRE-------------------ALRYDFLIAE-- 303
P G+L A+ + Y+ +G+ R+ A Y + E
Sbjct: 372 PKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLACSYGWNFTECT 431
Query: 304 -----------------KVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPA 346
VS L G++ ++L+S + L A ++ QC+ ++++ P
Sbjct: 432 QQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPL 491
Query: 347 LACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLS 406
+ G+G G NK PV L + +AF+ + ++N +API++ F+ +Y +++S F S
Sbjct: 492 IGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHAS 551
Query: 407 M 407
+
Sbjct: 552 I 552
Score = 44.7 bits (104), Expect = 3e-04
Identities = 21/62 (33%), Positives = 35/62 (56%), Gaps = 4/62 (6%)
Query: 582 WRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLG 641
WR S +Y N W +L GA+ S++IMF++ W L+ +GV + Y+ P ++ G
Sbjct: 558 WRPSFQYY----NKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWG 613
Query: 642 SA 643
S+
Sbjct: 614 SS 615
>gi|31881740 solute carrier family 12 (potassium/chloride
transporters), member 9 [Homo sapiens]
Length = 914
Score = 185 bits (470), Expect = 1e-46
Identities = 129/409 (31%), Positives = 209/409 (51%), Gaps = 44/409 (10%)
Query: 41 TWDGVFTSCMINIFGVVLFLRTGWLVGNTGVL--LGMFLVSFVILVALVTVLSGIGVGER 98
T+ GV ++++F +V+FLR G++VG+ G+L L M LV++ IL +TVLS +
Sbjct: 39 TFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILA--LTVLSVCAIATN 96
Query: 99 SSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLLGLGNIWAVR 158
++ GG Y MIS LG + GG+IGL++ A+ + G ES+ D+ G +
Sbjct: 97 GAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVLDVFG-ADATGPS 155
Query: 159 GISV------------AVLLALLG-INLAGVKWIIRLQLLLLFLLAVSTLDFVVGSF--- 202
G+ V ++LL L+G + G R L FLL +L V+ SF
Sbjct: 156 GLRVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLT-FLLVSGSLASVLISFVAV 214
Query: 203 ---------------THLDPEHG-FIGYSPELLQNNT----LPDYSPGE--SFFTVFGVF 240
+ L P G F G++ L++N DY+ G +F +VF V
Sbjct: 215 GPRDIRLTPRPGPNGSSLPPRFGHFTGFNSSTLKDNLGAGYAEDYTTGAVMNFASVFAVL 274
Query: 241 FPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREALRYDFL 300
F TG+MAG NM G+L++P+ +IPLG++ AV ++F+Y++ FL C R L+ D+
Sbjct: 275 FNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDRTLLQEDYG 334
Query: 301 IAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTP 360
+SL L L+G+Y ++L++ M L GA RIL +A++ + + + P
Sbjct: 335 FFRAISLWPPLVLIGIYATALSASMSSLIGASRILHALARDDLFGVILAPAKVVSRGGNP 394
Query: 361 VAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSMCS 409
AA+ + + + G++N LA +VT+ +++ Y AVD S SL S
Sbjct: 395 WAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEWAS 443
>gi|110224458 solute carrier family 12, member 6 isoform e [Homo
sapiens]
Length = 1135
Score = 104 bits (260), Expect = 2e-22
Identities = 59/176 (33%), Positives = 102/176 (57%), Gaps = 9/176 (5%)
Query: 232 SFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICT 291
SF + G+FFP+ TG+MAG N GDL++ SIP+G++ A+ + F+Y+ V L GA
Sbjct: 469 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 528
Query: 292 REALRYDFLIAEKVSLM--------GFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKV 343
LR F A K +L+ ++ ++G + S+ + + L GAPR+LQ IA++ +
Sbjct: 529 GVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNI 588
Query: 344 IPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVD 399
IP L G K N P A+ LT+ + + + ++++API+++ F++ Y+ V+
Sbjct: 589 IPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVN 643
Score = 90.9 bits (224), Expect = 4e-18
Identities = 62/207 (29%), Positives = 94/207 (45%), Gaps = 27/207 (13%)
Query: 12 HEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGV 71
HE A+ + +P Q+ GT+ GV+ C+ NIFGV+LFLR W+VG GV
Sbjct: 151 HEEAENITEGKKKPTKTPQM--------GTFMGVYLPCLQNIFGVILFLRLTWVVGTAGV 202
Query: 72 LLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQC 131
L +V ++T +S + + +GG Y MIS LG + GG +GL + G
Sbjct: 203 LQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTT 262
Query: 132 VAGAMYITGFAE-----------------SISDLLGLGNIWAVRGISVAVLLALLGINLA 174
A AMYI G E ++ + + N V G + VL+ L +
Sbjct: 263 FAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVL--VVFI 320
Query: 175 GVKWIIRLQLLLLFLLAVSTLDFVVGS 201
GV+++ + L L + VS L G+
Sbjct: 321 GVRYVNKFASLFLACVIVSILAIYAGA 347
Score = 33.1 bits (74), Expect = 0.92
Identities = 25/79 (31%), Positives = 36/79 (45%), Gaps = 16/79 (20%)
Query: 582 WRRSTSFYTHMCNPW-VSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYI--------- 631
WR +Y W +S +G L +MF+ W Y +V M +A ++Y YI
Sbjct: 657 WRPRFRYYH-----WALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEW 711
Query: 632 GRASPGLHLGSASNFSFFR 650
G GL L SA+ F+ R
Sbjct: 712 GDGIRGLSL-SAARFALLR 729
>gi|110224456 solute carrier family 12, member 6 isoform d [Homo
sapiens]
Length = 1141
Score = 104 bits (260), Expect = 2e-22
Identities = 59/176 (33%), Positives = 102/176 (57%), Gaps = 9/176 (5%)
Query: 232 SFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICT 291
SF + G+FFP+ TG+MAG N GDL++ SIP+G++ A+ + F+Y+ V L GA
Sbjct: 475 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 534
Query: 292 REALRYDFLIAEKVSLM--------GFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKV 343
LR F A K +L+ ++ ++G + S+ + + L GAPR+LQ IA++ +
Sbjct: 535 GVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNI 594
Query: 344 IPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVD 399
IP L G K N P A+ LT+ + + + ++++API+++ F++ Y+ V+
Sbjct: 595 IPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVN 649
Score = 90.9 bits (224), Expect = 4e-18
Identities = 62/207 (29%), Positives = 94/207 (45%), Gaps = 27/207 (13%)
Query: 12 HEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGV 71
HE A+ + +P Q+ GT+ GV+ C+ NIFGV+LFLR W+VG GV
Sbjct: 157 HEEAENITEGKKKPTKTPQM--------GTFMGVYLPCLQNIFGVILFLRLTWVVGTAGV 208
Query: 72 LLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQC 131
L +V ++T +S + + +GG Y MIS LG + GG +GL + G
Sbjct: 209 LQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTT 268
Query: 132 VAGAMYITGFAE-----------------SISDLLGLGNIWAVRGISVAVLLALLGINLA 174
A AMYI G E ++ + + N V G + VL+ L +
Sbjct: 269 FAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVL--VVFI 326
Query: 175 GVKWIIRLQLLLLFLLAVSTLDFVVGS 201
GV+++ + L L + VS L G+
Sbjct: 327 GVRYVNKFASLFLACVIVSILAIYAGA 353
Score = 33.1 bits (74), Expect = 0.92
Identities = 25/79 (31%), Positives = 36/79 (45%), Gaps = 16/79 (20%)
Query: 582 WRRSTSFYTHMCNPW-VSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYI--------- 631
WR +Y W +S +G L +MF+ W Y +V M +A ++Y YI
Sbjct: 663 WRPRFRYYH-----WALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEW 717
Query: 632 GRASPGLHLGSASNFSFFR 650
G GL L SA+ F+ R
Sbjct: 718 GDGIRGLSL-SAARFALLR 735
>gi|110224454 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 104 bits (260), Expect = 2e-22
Identities = 59/176 (33%), Positives = 102/176 (57%), Gaps = 9/176 (5%)
Query: 232 SFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICT 291
SF + G+FFP+ TG+MAG N GDL++ SIP+G++ A+ + F+Y+ V L GA
Sbjct: 425 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 484
Query: 292 REALRYDFLIAEKVSLM--------GFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKV 343
LR F A K +L+ ++ ++G + S+ + + L GAPR+LQ IA++ +
Sbjct: 485 GVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNI 544
Query: 344 IPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVD 399
IP L G K N P A+ LT+ + + + ++++API+++ F++ Y+ V+
Sbjct: 545 IPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVN 599
Score = 90.9 bits (224), Expect = 4e-18
Identities = 62/207 (29%), Positives = 94/207 (45%), Gaps = 27/207 (13%)
Query: 12 HEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGV 71
HE A+ + +P Q+ GT+ GV+ C+ NIFGV+LFLR W+VG GV
Sbjct: 107 HEEAENITEGKKKPTKTPQM--------GTFMGVYLPCLQNIFGVILFLRLTWVVGTAGV 158
Query: 72 LLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQC 131
L +V ++T +S + + +GG Y MIS LG + GG +GL + G
Sbjct: 159 LQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTT 218
Query: 132 VAGAMYITGFAE-----------------SISDLLGLGNIWAVRGISVAVLLALLGINLA 174
A AMYI G E ++ + + N V G + VL+ L +
Sbjct: 219 FAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVL--VVFI 276
Query: 175 GVKWIIRLQLLLLFLLAVSTLDFVVGS 201
GV+++ + L L + VS L G+
Sbjct: 277 GVRYVNKFASLFLACVIVSILAIYAGA 303
Score = 33.1 bits (74), Expect = 0.92
Identities = 25/79 (31%), Positives = 36/79 (45%), Gaps = 16/79 (20%)
Query: 582 WRRSTSFYTHMCNPW-VSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYI--------- 631
WR +Y W +S +G L +MF+ W Y +V M +A ++Y YI
Sbjct: 613 WRPRFRYYH-----WALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEW 667
Query: 632 GRASPGLHLGSASNFSFFR 650
G GL L SA+ F+ R
Sbjct: 668 GDGIRGLSL-SAARFALLR 685
>gi|110224452 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 104 bits (260), Expect = 2e-22
Identities = 59/176 (33%), Positives = 102/176 (57%), Gaps = 9/176 (5%)
Query: 232 SFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICT 291
SF + G+FFP+ TG+MAG N GDL++ SIP+G++ A+ + F+Y+ V L GA
Sbjct: 425 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 484
Query: 292 REALRYDFLIAEKVSLM--------GFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKV 343
LR F A K +L+ ++ ++G + S+ + + L GAPR+LQ IA++ +
Sbjct: 485 GVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNI 544
Query: 344 IPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVD 399
IP L G K N P A+ LT+ + + + ++++API+++ F++ Y+ V+
Sbjct: 545 IPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVN 599
Score = 90.9 bits (224), Expect = 4e-18
Identities = 62/207 (29%), Positives = 94/207 (45%), Gaps = 27/207 (13%)
Query: 12 HEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGV 71
HE A+ + +P Q+ GT+ GV+ C+ NIFGV+LFLR W+VG GV
Sbjct: 107 HEEAENITEGKKKPTKTPQM--------GTFMGVYLPCLQNIFGVILFLRLTWVVGTAGV 158
Query: 72 LLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQC 131
L +V ++T +S + + +GG Y MIS LG + GG +GL + G
Sbjct: 159 LQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTT 218
Query: 132 VAGAMYITGFAE-----------------SISDLLGLGNIWAVRGISVAVLLALLGINLA 174
A AMYI G E ++ + + N V G + VL+ L +
Sbjct: 219 FAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVL--VVFI 276
Query: 175 GVKWIIRLQLLLLFLLAVSTLDFVVGS 201
GV+++ + L L + VS L G+
Sbjct: 277 GVRYVNKFASLFLACVIVSILAIYAGA 303
Score = 33.1 bits (74), Expect = 0.92
Identities = 25/79 (31%), Positives = 36/79 (45%), Gaps = 16/79 (20%)
Query: 582 WRRSTSFYTHMCNPW-VSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYI--------- 631
WR +Y W +S +G L +MF+ W Y +V M +A ++Y YI
Sbjct: 613 WRPRFRYYH-----WALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEW 667
Query: 632 GRASPGLHLGSASNFSFFR 650
G GL L SA+ F+ R
Sbjct: 668 GDGIRGLSL-SAARFALLR 685
>gi|4826780 solute carrier family 12, member 6 isoform b [Homo
sapiens]
Length = 1099
Score = 104 bits (260), Expect = 2e-22
Identities = 59/176 (33%), Positives = 102/176 (57%), Gaps = 9/176 (5%)
Query: 232 SFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICT 291
SF + G+FFP+ TG+MAG N GDL++ SIP+G++ A+ + F+Y+ V L GA
Sbjct: 433 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 492
Query: 292 REALRYDFLIAEKVSLM--------GFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKV 343
LR F A K +L+ ++ ++G + S+ + + L GAPR+LQ IA++ +
Sbjct: 493 GVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNI 552
Query: 344 IPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVD 399
IP L G K N P A+ LT+ + + + ++++API+++ F++ Y+ V+
Sbjct: 553 IPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVN 607
Score = 90.9 bits (224), Expect = 4e-18
Identities = 62/207 (29%), Positives = 94/207 (45%), Gaps = 27/207 (13%)
Query: 12 HEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGV 71
HE A+ + +P Q+ GT+ GV+ C+ NIFGV+LFLR W+VG GV
Sbjct: 115 HEEAENITEGKKKPTKTPQM--------GTFMGVYLPCLQNIFGVILFLRLTWVVGTAGV 166
Query: 72 LLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQC 131
L +V ++T +S + + +GG Y MIS LG + GG +GL + G
Sbjct: 167 LQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTT 226
Query: 132 VAGAMYITGFAE-----------------SISDLLGLGNIWAVRGISVAVLLALLGINLA 174
A AMYI G E ++ + + N V G + VL+ L +
Sbjct: 227 FAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVL--VVFI 284
Query: 175 GVKWIIRLQLLLLFLLAVSTLDFVVGS 201
GV+++ + L L + VS L G+
Sbjct: 285 GVRYVNKFASLFLACVIVSILAIYAGA 311
Score = 33.1 bits (74), Expect = 0.92
Identities = 25/79 (31%), Positives = 36/79 (45%), Gaps = 16/79 (20%)
Query: 582 WRRSTSFYTHMCNPW-VSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYI--------- 631
WR +Y W +S +G L +MF+ W Y +V M +A ++Y YI
Sbjct: 621 WRPRFRYYH-----WALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEW 675
Query: 632 GRASPGLHLGSASNFSFFR 650
G GL L SA+ F+ R
Sbjct: 676 GDGIRGLSL-SAARFALLR 693
>gi|110224449 solute carrier family 12, member 6 isoform a [Homo
sapiens]
Length = 1150
Score = 104 bits (260), Expect = 2e-22
Identities = 59/176 (33%), Positives = 102/176 (57%), Gaps = 9/176 (5%)
Query: 232 SFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICT 291
SF + G+FFP+ TG+MAG N GDL++ SIP+G++ A+ + F+Y+ V L GA
Sbjct: 484 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 543
Query: 292 REALRYDFLIAEKVSLM--------GFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKV 343
LR F A K +L+ ++ ++G + S+ + + L GAPR+LQ IA++ +
Sbjct: 544 GVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNI 603
Query: 344 IPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVD 399
IP L G K N P A+ LT+ + + + ++++API+++ F++ Y+ V+
Sbjct: 604 IPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVN 658
Score = 90.9 bits (224), Expect = 4e-18
Identities = 62/207 (29%), Positives = 94/207 (45%), Gaps = 27/207 (13%)
Query: 12 HEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGV 71
HE A+ + +P Q+ GT+ GV+ C+ NIFGV+LFLR W+VG GV
Sbjct: 166 HEEAENITEGKKKPTKTPQM--------GTFMGVYLPCLQNIFGVILFLRLTWVVGTAGV 217
Query: 72 LLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQC 131
L +V ++T +S + + +GG Y MIS LG + GG +GL + G
Sbjct: 218 LQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTT 277
Query: 132 VAGAMYITGFAE-----------------SISDLLGLGNIWAVRGISVAVLLALLGINLA 174
A AMYI G E ++ + + N V G + VL+ L +
Sbjct: 278 FAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVL--VVFI 335
Query: 175 GVKWIIRLQLLLLFLLAVSTLDFVVGS 201
GV+++ + L L + VS L G+
Sbjct: 336 GVRYVNKFASLFLACVIVSILAIYAGA 362
Score = 33.1 bits (74), Expect = 0.92
Identities = 25/79 (31%), Positives = 36/79 (45%), Gaps = 16/79 (20%)
Query: 582 WRRSTSFYTHMCNPW-VSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYI--------- 631
WR +Y W +S +G L +MF+ W Y +V M +A ++Y YI
Sbjct: 672 WRPRFRYYH-----WALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEW 726
Query: 632 GRASPGLHLGSASNFSFFR 650
G GL L SA+ F+ R
Sbjct: 727 GDGIRGLSL-SAARFALLR 744
>gi|225579067 solute carrier family 12, member 4 isoform e [Homo
sapiens]
Length = 1054
Score = 102 bits (253), Expect = 2e-21
Identities = 57/176 (32%), Positives = 99/176 (56%), Gaps = 9/176 (5%)
Query: 232 SFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICT 291
SF + G+FFP+ TG+MAG N GDLR+ SIP+G++ A+ + +Y V L GA
Sbjct: 388 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIE 447
Query: 292 REALR--------YDFLIAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKV 343
LR + ++ ++ ++G + S+ + + L GAPR+LQ IA++ +
Sbjct: 448 GVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNI 507
Query: 344 IPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVD 399
IP L G GK N P A+ LT+L+ + + ++++API+++ F++ Y+ V+
Sbjct: 508 IPFLRVFGHGK-VNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVN 562
Score = 86.7 bits (213), Expect = 7e-17
Identities = 44/104 (42%), Positives = 58/104 (55%)
Query: 40 GTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERS 99
GT GV+ C+ NIFGV+LFLR W+VG GVL + +V L+T +S +
Sbjct: 88 GTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNG 147
Query: 100 SIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAE 143
+ +GG Y MIS LG + GG +GL + G A AMYI G E
Sbjct: 148 VVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIE 191
Score = 34.3 bits (77), Expect = 0.41
Identities = 20/51 (39%), Positives = 26/51 (50%), Gaps = 6/51 (11%)
Query: 582 WRRSTSFYTHMCNPW-VSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYI 631
WR +Y W +S LG L +MFV W Y LV M +A ++Y YI
Sbjct: 576 WRPRFKYYH-----WALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYI 621
>gi|225579065 solute carrier family 12, member 4 isoform d [Homo
sapiens]
Length = 1079
Score = 102 bits (253), Expect = 2e-21
Identities = 57/176 (32%), Positives = 99/176 (56%), Gaps = 9/176 (5%)
Query: 232 SFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICT 291
SF + G+FFP+ TG+MAG N GDLR+ SIP+G++ A+ + +Y V L GA
Sbjct: 413 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIE 472
Query: 292 REALR--------YDFLIAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKV 343
LR + ++ ++ ++G + S+ + + L GAPR+LQ IA++ +
Sbjct: 473 GVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNI 532
Query: 344 IPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVD 399
IP L G GK N P A+ LT+L+ + + ++++API+++ F++ Y+ V+
Sbjct: 533 IPFLRVFGHGK-VNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVN 587
Score = 86.7 bits (213), Expect = 7e-17
Identities = 44/104 (42%), Positives = 58/104 (55%)
Query: 40 GTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERS 99
GT GV+ C+ NIFGV+LFLR W+VG GVL + +V L+T +S +
Sbjct: 113 GTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNG 172
Query: 100 SIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAE 143
+ +GG Y MIS LG + GG +GL + G A AMYI G E
Sbjct: 173 VVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIE 216
Score = 34.3 bits (77), Expect = 0.41
Identities = 20/51 (39%), Positives = 26/51 (50%), Gaps = 6/51 (11%)
Query: 582 WRRSTSFYTHMCNPW-VSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYI 631
WR +Y W +S LG L +MFV W Y LV M +A ++Y YI
Sbjct: 601 WRPRFKYYH-----WALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYI 646
>gi|225579063 solute carrier family 12, member 4 isoform c [Homo
sapiens]
Length = 1087
Score = 102 bits (253), Expect = 2e-21
Identities = 57/176 (32%), Positives = 99/176 (56%), Gaps = 9/176 (5%)
Query: 232 SFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICT 291
SF + G+FFP+ TG+MAG N GDLR+ SIP+G++ A+ + +Y V L GA
Sbjct: 421 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIE 480
Query: 292 REALR--------YDFLIAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKV 343
LR + ++ ++ ++G + S+ + + L GAPR+LQ IA++ +
Sbjct: 481 GVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNI 540
Query: 344 IPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVD 399
IP L G GK N P A+ LT+L+ + + ++++API+++ F++ Y+ V+
Sbjct: 541 IPFLRVFGHGK-VNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVN 595
Score = 86.7 bits (213), Expect = 7e-17
Identities = 44/104 (42%), Positives = 58/104 (55%)
Query: 40 GTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERS 99
GT GV+ C+ NIFGV+LFLR W+VG GVL + +V L+T +S +
Sbjct: 121 GTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNG 180
Query: 100 SIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAE 143
+ +GG Y MIS LG + GG +GL + G A AMYI G E
Sbjct: 181 VVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIE 224
Score = 34.3 bits (77), Expect = 0.41
Identities = 20/51 (39%), Positives = 26/51 (50%), Gaps = 6/51 (11%)
Query: 582 WRRSTSFYTHMCNPW-VSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYI 631
WR +Y W +S LG L +MFV W Y LV M +A ++Y YI
Sbjct: 609 WRPRFKYYH-----WALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYI 654
>gi|225579061 solute carrier family 12, member 4 isoform b [Homo
sapiens]
Length = 1079
Score = 102 bits (253), Expect = 2e-21
Identities = 57/176 (32%), Positives = 99/176 (56%), Gaps = 9/176 (5%)
Query: 232 SFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICT 291
SF + G+FFP+ TG+MAG N GDLR+ SIP+G++ A+ + +Y V L GA
Sbjct: 419 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIE 478
Query: 292 REALR--------YDFLIAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKV 343
LR + ++ ++ ++G + S+ + + L GAPR+LQ IA++ +
Sbjct: 479 GVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNI 538
Query: 344 IPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVD 399
IP L G GK N P A+ LT+L+ + + ++++API+++ F++ Y+ V+
Sbjct: 539 IPFLRVFGHGK-VNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVN 593
Score = 86.7 bits (213), Expect = 7e-17
Identities = 44/104 (42%), Positives = 58/104 (55%)
Query: 40 GTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERS 99
GT GV+ C+ NIFGV+LFLR W+VG GVL + +V L+T +S +
Sbjct: 119 GTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNG 178
Query: 100 SIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAE 143
+ +GG Y MIS LG + GG +GL + G A AMYI G E
Sbjct: 179 VVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIE 222
Score = 34.3 bits (77), Expect = 0.41
Identities = 20/51 (39%), Positives = 26/51 (50%), Gaps = 6/51 (11%)
Query: 582 WRRSTSFYTHMCNPW-VSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYI 631
WR +Y W +S LG L +MFV W Y LV M +A ++Y YI
Sbjct: 607 WRPRFKYYH-----WALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYI 652
>gi|4827006 solute carrier family 12, member 4 isoform a [Homo
sapiens]
Length = 1085
Score = 102 bits (253), Expect = 2e-21
Identities = 57/176 (32%), Positives = 99/176 (56%), Gaps = 9/176 (5%)
Query: 232 SFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICT 291
SF + G+FFP+ TG+MAG N GDLR+ SIP+G++ A+ + +Y V L GA
Sbjct: 419 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIE 478
Query: 292 REALR--------YDFLIAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKV 343
LR + ++ ++ ++G + S+ + + L GAPR+LQ IA++ +
Sbjct: 479 GVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNI 538
Query: 344 IPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVD 399
IP L G GK N P A+ LT+L+ + + ++++API+++ F++ Y+ V+
Sbjct: 539 IPFLRVFGHGK-VNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVN 593
Score = 86.7 bits (213), Expect = 7e-17
Identities = 44/104 (42%), Positives = 58/104 (55%)
Query: 40 GTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERS 99
GT GV+ C+ NIFGV+LFLR W+VG GVL + +V L+T +S +
Sbjct: 119 GTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNG 178
Query: 100 SIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAE 143
+ +GG Y MIS LG + GG +GL + G A AMYI G E
Sbjct: 179 VVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIE 222
Score = 34.3 bits (77), Expect = 0.41
Identities = 20/51 (39%), Positives = 26/51 (50%), Gaps = 6/51 (11%)
Query: 582 WRRSTSFYTHMCNPW-VSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYI 631
WR +Y W +S LG L +MFV W Y LV M +A ++Y YI
Sbjct: 607 WRPRFKYYH-----WALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYI 652
>gi|123701900 solute carrier family 12 (potassium/chloride
transporters), member 7 [Homo sapiens]
Length = 1083
Score = 102 bits (253), Expect = 2e-21
Identities = 57/176 (32%), Positives = 101/176 (57%), Gaps = 9/176 (5%)
Query: 232 SFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICT 291
SF + G++FP+ TG+MAG N GDL++ SIP G++ A+ + F+Y+ + L GA
Sbjct: 419 SFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIE 478
Query: 292 REALRYDFLIAEKVSLM--------GFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKV 343
LR F A + +L+ ++ ++G + S+ + + L GAPR+LQ IA++ +
Sbjct: 479 GVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGI 538
Query: 344 IPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVD 399
+P L G GK N P A+ LT L+ + + ++ +API+++ F++ Y+ V+
Sbjct: 539 VPFLQVFGHGKA-NGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLFVN 593
Score = 93.2 bits (230), Expect = 7e-19
Identities = 71/242 (29%), Positives = 107/242 (44%), Gaps = 27/242 (11%)
Query: 40 GTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERS 99
GT+ GV+ C+ NI GV+LFLR W+VG GVL +V+ ++T +S +
Sbjct: 119 GTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIATNG 178
Query: 100 SIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLLGLG------- 152
+ +GG Y MIS LG + GG +GL + G AGAMYI G E + G
Sbjct: 179 VVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIFQAE 238
Query: 153 ----------NIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVGSF 202
+ V G VL+AL + GVK++ +L L+ L + +S L G
Sbjct: 239 AAGGEAAAMLHNMRVYGTCTLVLMAL--VVFVGVKYVNKLALVFLACVVLSILAIYAGVI 296
Query: 203 -THLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVFFPAATGVMAGFNMGGDLREPA 261
+ DP P L N ++ +G+ +AT + G G +P+
Sbjct: 297 KSAFDPPD-----IPVCLLGNRTLSRRSFDACVKAYGIHNNSATSALWGLFCNGS--QPS 349
Query: 262 AS 263
A+
Sbjct: 350 AA 351
Score = 32.3 bits (72), Expect = 1.6
Identities = 19/51 (37%), Positives = 24/51 (47%), Gaps = 6/51 (11%)
Query: 582 WRRSTSFYTHMCNPW-VSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYI 631
WR FY W +S LG L +MF+ W Y L M +A +Y YI
Sbjct: 607 WRPRFKFYH-----WTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYI 652
>gi|198041678 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 1 [Homo sapiens]
Length = 1139
Score = 100 bits (249), Expect = 5e-21
Identities = 59/182 (32%), Positives = 103/182 (56%), Gaps = 10/182 (5%)
Query: 227 YSPGESFFTVF-GVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFL 285
+S S+FT+ G++FP+ TG+MAG N GDLR+ SIP G++ A+ + +YI V L
Sbjct: 416 FSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVL 475
Query: 286 LGAICTREALRYDFLIAEKVSLM--------GFLFLLGLYISSLASCMGGLYGAPRILQC 337
GA LR F A +L+ ++ ++G + S+ + + L GAPR+LQ
Sbjct: 476 FGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQA 535
Query: 338 IAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVA 397
I+++ ++P L G GK N P A+ LT+ + + + ++ +API+++ F++ Y+
Sbjct: 536 ISRDGIVPFLQVFGHGKA-NGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMF 594
Query: 398 VD 399
V+
Sbjct: 595 VN 596
Score = 87.4 bits (215), Expect = 4e-17
Identities = 54/176 (30%), Positives = 82/176 (46%), Gaps = 15/176 (8%)
Query: 40 GTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERS 99
GT+ GV+ C+ NIFGV+LFLR W+VG G++ +V ++T +S +
Sbjct: 121 GTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNG 180
Query: 100 SIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLL---------- 149
+ +GG Y MIS LG + GG +GL + G AGAMYI G E + L
Sbjct: 181 VVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAE 240
Query: 150 -----GLGNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVG 200
+ +R VL + + GVK++ + L+ L + +S L G
Sbjct: 241 DASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAG 296
Score = 36.2 bits (82), Expect = 0.11
Identities = 34/122 (27%), Positives = 52/122 (42%), Gaps = 30/122 (24%)
Query: 582 WRRSTSFYTHMCNPW-VSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYI--------- 631
WR +Y W +S LG L +MF+ W Y LV M +A ++Y YI
Sbjct: 610 WRPRFRYYH-----WTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEW 664
Query: 632 GRASPGLHLGSASNFSFFR----------WMRSLLLPSCRSLRSPQEQIILAPSLAKVDM 681
G GL L SA+ ++ R W LL+ +R Q+Q ++ P L +
Sbjct: 665 GDGIRGLSL-SAARYALLRLEEGPPHTKNWRPQLLV----LVRVDQDQNVVHPQLLSLTS 719
Query: 682 EM 683
++
Sbjct: 720 QL 721
>gi|11968148 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 2 [Homo sapiens]
Length = 1116
Score = 100 bits (249), Expect = 5e-21
Identities = 59/182 (32%), Positives = 103/182 (56%), Gaps = 10/182 (5%)
Query: 227 YSPGESFFTVF-GVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFL 285
+S S+FT+ G++FP+ TG+MAG N GDLR+ SIP G++ A+ + +YI V L
Sbjct: 393 FSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVL 452
Query: 286 LGAICTREALRYDFLIAEKVSLM--------GFLFLLGLYISSLASCMGGLYGAPRILQC 337
GA LR F A +L+ ++ ++G + S+ + + L GAPR+LQ
Sbjct: 453 FGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQA 512
Query: 338 IAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVA 397
I+++ ++P L G GK N P A+ LT+ + + + ++ +API+++ F++ Y+
Sbjct: 513 ISRDGIVPFLQVFGHGKA-NGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMF 571
Query: 398 VD 399
V+
Sbjct: 572 VN 573
Score = 87.4 bits (215), Expect = 4e-17
Identities = 54/176 (30%), Positives = 82/176 (46%), Gaps = 15/176 (8%)
Query: 40 GTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERS 99
GT+ GV+ C+ NIFGV+LFLR W+VG G++ +V ++T +S +
Sbjct: 98 GTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNG 157
Query: 100 SIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLL---------- 149
+ +GG Y MIS LG + GG +GL + G AGAMYI G E + L
Sbjct: 158 VVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAE 217
Query: 150 -----GLGNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVG 200
+ +R VL + + GVK++ + L+ L + +S L G
Sbjct: 218 DASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAG 273
Score = 36.2 bits (82), Expect = 0.11
Identities = 34/122 (27%), Positives = 52/122 (42%), Gaps = 30/122 (24%)
Query: 582 WRRSTSFYTHMCNPW-VSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYI--------- 631
WR +Y W +S LG L +MF+ W Y LV M +A ++Y YI
Sbjct: 587 WRPRFRYYH-----WTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEW 641
Query: 632 GRASPGLHLGSASNFSFFR----------WMRSLLLPSCRSLRSPQEQIILAPSLAKVDM 681
G GL L SA+ ++ R W LL+ +R Q+Q ++ P L +
Sbjct: 642 GDGIRGLSL-SAARYALLRLEEGPPHTKNWRPQLLV----LVRVDQDQNVVHPQLLSLTS 696
Query: 682 EM 683
++
Sbjct: 697 QL 698
>gi|4507047 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 1 [Homo sapiens]
Length = 629
Score = 59.3 bits (142), Expect = 1e-08
Identities = 87/362 (24%), Positives = 150/362 (41%), Gaps = 45/362 (12%)
Query: 77 LVSFVILVALVTVLSGIGVGERSS----IGSGGVYSMIS--SVLGGQTGGTIGLLYVFGQ 130
++SF+I AL +VL+G+ GE + GS +YS ++ + TG + L Y+ G
Sbjct: 67 VISFLI-AALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGT 125
Query: 131 CVAGAMYITGFAESISDLLGL-----------------GNIWAVRGISVAVLLALLGINL 173
+ F E I +G +I+AV I + L LG+
Sbjct: 126 SSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKE 185
Query: 174 AGV--KWIIRLQLLLLFLLAVSTLDFVVGSFTHLD-PEHGFIGYSPELLQNNTLPDYSPG 230
+ + K + +L+L + VS FV GS + E F S L NN + PG
Sbjct: 186 SAMVNKIFTCINVLVLGFIMVS--GFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEGKPG 243
Query: 231 ESFFTVFG---VFFPAATGVMA--GFNM----GGDLREPAASIPLGSLAAVGISWFLYIV 281
F FG V AAT A GF+ G +++ P +IP+G +A++ I + Y
Sbjct: 244 VGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFG 303
Query: 282 FVFLLGAICTREALRYDFLIAEKVSLMG-----FLFLLGLYISSLASCMGGLYGAPRILQ 336
L + L + + + +G + +G + AS +G ++ PR++
Sbjct: 304 VSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPRVIY 363
Query: 337 CIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYV 396
+A++ ++ L KTP+ A + V F+ + L +++I +L Y
Sbjct: 364 AMAEDGLL--FKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYS 421
Query: 397 AV 398
V
Sbjct: 422 LV 423
>gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo
sapiens]
Length = 658
Score = 57.4 bits (137), Expect = 5e-08
Identities = 83/373 (22%), Positives = 150/373 (40%), Gaps = 67/373 (17%)
Query: 77 LVSFVILVALVTVLSGIGVGERSS----IGSGGVYSMIS--SVLGGQTGGTIGLLYVFGQ 130
+VSF+I AL +V++G+ E + GS +Y+ ++ + TG + L YV G
Sbjct: 69 VVSFLI-AALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGT 127
Query: 131 CVAGAMYITGFAESISDLLG-----------LGNIWAVRGISVAVLLALLGINLAGVK-- 177
+ F E +S +G G +V ++L L G+ GVK
Sbjct: 128 SSVARAWSGTFDELLSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLLSFGVKES 187
Query: 178 -WIIRL--QLLLLFLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQN-NTLPDYSPGESF 233
W+ ++ + +L LL V FV G+ + S E L+N + P E+
Sbjct: 188 AWVNKVFTAVNILVLLFVMVAGFVKGNVANWK-------ISEEFLKNISASAREPPSENG 240
Query: 234 FTVFGV--FFPAA-TGVMAGF--------------NMGGDLREPAASIPLGSLAAVGISW 276
+++G F P TG +AG G ++R P +IP+G + +
Sbjct: 241 TSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTS----- 295
Query: 277 FLYIVFVFLLGAICTREALRYDFLIAEKVSL-----------MGFLFLLGLYISSLASCM 325
L + F+ G + +L+ EK L ++ G + S +
Sbjct: 296 -LLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLL 354
Query: 326 GGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAP 385
G ++ PR++ +A++ ++ CL Q KTP+ A + V F+ + L
Sbjct: 355 GSIFPMPRVIYAMAEDGLL--FKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVD 412
Query: 386 IVTINFMLTYVAV 398
+++I ++ Y V
Sbjct: 413 MMSIGTLMAYSLV 425
>gi|33286428 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 8 isoform a [Homo
sapiens]
Length = 535
Score = 52.4 bits (124), Expect = 1e-06
Identities = 77/383 (20%), Positives = 160/383 (41%), Gaps = 48/383 (12%)
Query: 44 GVFTSCMI---NIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSS 100
G+ ++C I NI G +F+ ++ N G + G+ L+ +++ +TV+ + E
Sbjct: 41 GLVSACGIIVGNIIGSGIFVSPKGVLENAGSV-GLALIVWIV-TGFITVVGALCYAELGV 98
Query: 101 I--GSGGVYSMISSVLGGQTGG-----TIGLLYVFGQCVAGAMYITGFAESISDLLGLGN 153
SGG YS + + GG G + ++Y Q V + + +
Sbjct: 99 TIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPE 158
Query: 154 IWAVRGISVAVLLALLGINLAGVKWIIRLQ--------LLLLFLLAVSTLDFVVGSFTHL 205
+R ++ LL L +N + V+W R+Q L L ++ + + G + L
Sbjct: 159 S-GLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWL 217
Query: 206 DPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVFFPAATGVMAGFN----MGGDLREPA 261
+P++ F +N PD + + F + G+N + +L +P
Sbjct: 218 EPKNAF--------ENFQEPDIG-------LVALAFLQGSFAYGGWNFLNYVTEELVDPY 262
Query: 262 ASIPLGSLAAVGISWFLYI-VFVFLLGAICTREALRYDFL---IAEK-VSLMGFLFLLGL 316
++P ++ + F+Y+ V + A+ +E L + + EK + +M ++ + +
Sbjct: 263 KNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISV 322
Query: 317 YISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVF 376
+S+ G L+ + R+ A+E +P++ + K TP+ A+ T + T+ +
Sbjct: 323 ALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVK--RCTPIPALLFTCISTLLMLV 380
Query: 377 VGQVNVLAPIV-TINFMLTYVAV 398
+ L V IN++ V V
Sbjct: 381 TSDMYTLINYVGFINYLFYGVTV 403
>gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo
sapiens]
Length = 697
Score = 48.5 bits (114), Expect = 2e-05
Identities = 83/374 (22%), Positives = 153/374 (40%), Gaps = 70/374 (18%)
Query: 77 LVSFVILVALVTVLSGIGVGERSS----IGSGGVYSMIS--SVLGGQTGGTIGLLYVFGQ 130
+VSF+I AL +V++G+ E + GS +Y+ ++ + TG + L YV G
Sbjct: 109 VVSFLI-AALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGT 167
Query: 131 CVAGAMYITGFAESISDLLG-----------LGNIWAVRGISVAVLLALLGINLAGVK-- 177
+ F E +S +G G +V ++L L G+ GVK
Sbjct: 168 SSVARAWSGTFDELLSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLLSFGVKES 227
Query: 178 -WIIRL--QLLLLFLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQN-NTLPDYSPGESF 233
W+ ++ + +L LL V FV G+ + S E L+N + P E+
Sbjct: 228 AWVNKVFTAVNILVLLFVMVAGFVKGNVANWK-------ISEEFLKNISASAREPPSENG 280
Query: 234 FTVFGV--FFPAA-TGVMAGF--------------NMGGDLREPAASIPLGSLAAVGISW 276
+++G F P TG +AG G ++R P +IP+G + +
Sbjct: 281 TSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTS----- 335
Query: 277 FLYIVFVFLLGAICTREALRYDFLIAEKVSL-----------MGFLFLLGLYISSLASCM 325
L + F+ G + +L+ EK L ++ G + S +
Sbjct: 336 -LLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLL 394
Query: 326 GGLYGAPRILQCIAQEKVI-PALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLA 384
G ++ PRIL +A++ ++ LA + + ++PVAA +++ F+ + L
Sbjct: 395 GSMFPLPRILFAMARDGLLFRFLARVSK----RQSPVAATLTAGVISALMAFLFDLKALV 450
Query: 385 PIVTINFMLTYVAV 398
+++I ++ Y V
Sbjct: 451 DMMSIGTLMAYSLV 464
>gi|114326550 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 3 [Homo sapiens]
Length = 619
Score = 44.3 bits (103), Expect = 4e-04
Identities = 82/389 (21%), Positives = 156/389 (40%), Gaps = 47/389 (12%)
Query: 74 GMFLVSFVILVALVTVLSGIGVGERSS----IGSGGVYSMIS--SVLGGQTGGTIGLLYV 127
G +V ++ AL +VL+G+ E + GS +YS ++ + TG + L YV
Sbjct: 63 GPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYV 122
Query: 128 FGQCVAGAMYITGFAESISD-----------------LLGLGNIWAVRGISVAVLLALLG 170
G + + F I + L + +A+ + + L LG
Sbjct: 123 IGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALG 182
Query: 171 INLAGVKWIIRLQLLLLFLLAVSTLDFVVGSFTHLD-PEHGFIGYSPELLQNNTL-PDYS 228
+ + + + + LL L V FV G + E + EL +L P S
Sbjct: 183 ASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGS 242
Query: 229 PGESFFTVFGVFFPAATGVMA--GFNM----GGDLREPAASIPLGSLAAVGISWFLYIVF 282
G F G+ AAT A GF+ G + + P SIP+G + ++ + + Y
Sbjct: 243 GGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAV 302
Query: 283 VFLLGAICTREALRYDFLIAEKVSLMG-----FLFLLGLYISSLASCMGGLYGAPRILQC 337
L + L+ + + E +G ++ +G + S +G ++ PR++
Sbjct: 303 SSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYA 362
Query: 338 IAQEKVI-PALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYV 396
+A++ ++ LA + G +TP+ A ++ ++ F+ ++ L +++I +L Y
Sbjct: 363 MAEDGLLFRVLARIHTG---TRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYS 419
Query: 397 AVDYSYFSLSMCSCSLTPVPEPVLREGAE 425
V S+C L P+ + G E
Sbjct: 420 LV-------SICVLILRYQPDQETKTGEE 441
>gi|114326544 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 3 [Homo sapiens]
Length = 619
Score = 44.3 bits (103), Expect = 4e-04
Identities = 82/389 (21%), Positives = 156/389 (40%), Gaps = 47/389 (12%)
Query: 74 GMFLVSFVILVALVTVLSGIGVGERSS----IGSGGVYSMIS--SVLGGQTGGTIGLLYV 127
G +V ++ AL +VL+G+ E + GS +YS ++ + TG + L YV
Sbjct: 63 GPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYV 122
Query: 128 FGQCVAGAMYITGFAESISD-----------------LLGLGNIWAVRGISVAVLLALLG 170
G + + F I + L + +A+ + + L LG
Sbjct: 123 IGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALG 182
Query: 171 INLAGVKWIIRLQLLLLFLLAVSTLDFVVGSFTHLD-PEHGFIGYSPELLQNNTL-PDYS 228
+ + + + + LL L V FV G + E + EL +L P S
Sbjct: 183 ASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGS 242
Query: 229 PGESFFTVFGVFFPAATGVMA--GFNM----GGDLREPAASIPLGSLAAVGISWFLYIVF 282
G F G+ AAT A GF+ G + + P SIP+G + ++ + + Y
Sbjct: 243 GGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAV 302
Query: 283 VFLLGAICTREALRYDFLIAEKVSLMG-----FLFLLGLYISSLASCMGGLYGAPRILQC 337
L + L+ + + E +G ++ +G + S +G ++ PR++
Sbjct: 303 SSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYA 362
Query: 338 IAQEKVI-PALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYV 396
+A++ ++ LA + G +TP+ A ++ ++ F+ ++ L +++I +L Y
Sbjct: 363 MAEDGLLFRVLARIHTG---TRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYS 419
Query: 397 AVDYSYFSLSMCSCSLTPVPEPVLREGAE 425
V S+C L P+ + G E
Sbjct: 420 LV-------SICVLILRYQPDQETKTGEE 441
>gi|9790235 solute carrier family 7, member 10 [Homo sapiens]
Length = 523
Score = 41.2 bits (95), Expect = 0.003
Identities = 80/384 (20%), Positives = 150/384 (39%), Gaps = 50/384 (13%)
Query: 44 GVFTSCMI---NIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSS 100
G+ ++C I NI G +F+ ++ ++G + G+ L +V L VT L + E
Sbjct: 41 GLLSACTIIIGNIIGSGIFISPKGVLEHSGSV-GLALFVWV-LGGGVTALGSLCYAELGV 98
Query: 101 I--GSGGVYSMISSVLGGQTG-----GTIGLLYVFGQCVAGAMYITGFAESISDLLGLGN 153
SGG Y+ ++ + GG G + ++Y V + + + +
Sbjct: 99 AIPKSGGDYAYVTEIFGGLAGFLLLWSAVLIMYPTSLAVISMTFSNYVLQPVFPNC-IPP 157
Query: 154 IWAVRGISVAVLLALLGINLAGVKWIIRLQ--------LLLLFLLAVSTLDFVVGSFTHL 205
A R +S+A L+ L +N + V+W R+Q L L ++ V L G F L
Sbjct: 158 TTASRVLSMACLMLLTWVNSSSVRWATRIQDMFTGGKLLALSLIIGVGLLQIFQGHFEEL 217
Query: 206 DPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVFFPAATGVMAGFNMGGDLREPAASIP 265
P + F + + + L F + +G+N + E
Sbjct: 218 RPSNAFAFWMTPSVGHLALA---------------FLQGSFAFSGWNFLNYVTEEMVDAR 262
Query: 266 LGSLAAVGISWFLYIVFVFLLGAICTREALRYDFLIAEKV-------SLMGF---LFLLG 315
A+ IS L + FV+ I A+ L++ L+G+ + +
Sbjct: 263 KNLPRAIFISIPL-VTFVYTFTNIAYFTAMSPQELLSSNAVAVTFGEKLLGYFSWVMPVS 321
Query: 316 LYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFV 375
+ +S+ G L+ R+ A+E +P+L + + + TP+ A+ + T +
Sbjct: 322 VALSTFGGINGYLFTYSRLCFSGAREGHLPSLLAMIHVR--HCTPIPALLVCCGATAVIM 379
Query: 376 FVGQVNVLAPIVT-INFMLTYVAV 398
VG L V+ IN++ V +
Sbjct: 380 LVGDTYTLINYVSFINYLCYGVTI 403
>gi|54112380 F-box and leucine-rich repeat protein 10 isoform b
[Homo sapiens]
Length = 1265
Score = 38.1 bits (87), Expect = 0.029
Identities = 33/121 (27%), Positives = 53/121 (43%), Gaps = 3/121 (2%)
Query: 436 EKAPSYGSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQGEGNRTPESQKR--KS 493
E+AP S+ +++V LL D D L+ RK E Q G P + + +
Sbjct: 740 EEAPRRRSDEHSKKVPPDGLLRRKSD-DVHLRKKRKYEKPQELSGRKRLKPGKEDKLFRK 798
Query: 494 KKATKQTLQDSFLLDLKSPPSFPVEISDRLPAASWEGQESCWNKQTSKSEGTQPEGTYGE 553
K+ + + +D L K F E D LP A + +ES ++ +S + G EG G
Sbjct: 799 KRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGP 858
Query: 554 Q 554
+
Sbjct: 859 E 859
>gi|7657683 solute carrier family 7, (cationic amino acid
transporter, y+ system) member 11 [Homo sapiens]
Length = 501
Score = 37.4 bits (85), Expect = 0.049
Identities = 74/359 (20%), Positives = 134/359 (37%), Gaps = 55/359 (15%)
Query: 53 IFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIG-----SGGVY 107
I G +F+ ++ NTG + GM L + + VLS G + +G SGG Y
Sbjct: 57 IIGAGIFISPKGVLQNTGSV-GMSLTIWTVC----GVLSLFGALSYAELGTTIKKSGGHY 111
Query: 108 SMISSVLGG--------------QTGGTIGLLYVFGQCVAGAMYITGFAESISDLLGLGN 153
+ I V G + T + FG+ + +I I +L
Sbjct: 112 TYILEVFGPLPAFVRVWVELLIIRPAATAVISLAFGRYILEPFFIQC---EIPEL----- 163
Query: 154 IWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVGSFTHLDPEHGFIG 213
A++ I+ + ++ +N V W R+Q+ L F + L +V L
Sbjct: 164 --AIKLITAVGITVVMVLNSMSVSWSARIQIFLTFCKLTAILIIIVPGVMQLIKGQ---- 217
Query: 214 YSPELLQNNTLPDYSPGESFFTVFGVFFPAATGVMAGF----NMGGDLREPAASIPLGSL 269
N +S +S T + F AG+ + ++ P +IPL
Sbjct: 218 ------TQNFKDAFSGRDSSITRLPLAFYYGMYAYAGWFYLNFVTEEVENPEKTIPLAIC 271
Query: 270 AAVGISWFLYIVFVFLLGAICTREALRYDFLIAEKVS--LMGFLFL---LGLYISSLASC 324
++ I Y++ E L +A S L+G L + + +S S
Sbjct: 272 ISMAIVTIGYVLTNVAYFTTINAEELLLSNAVAVTFSERLLGNFSLAVPIFVALSCFGSM 331
Query: 325 MGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVL 383
GG++ R+ ++E +P + + + TP+ A+ + +TM +F G ++ L
Sbjct: 332 NGGVFAVSRLFYVASREGHLPEILSMIHVR--KHTPLPAVIVLHPLTMIMLFSGDLDSL 388
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,931,328
Number of Sequences: 37866
Number of extensions: 1234697
Number of successful extensions: 3548
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 29
Number of HSP's that attempted gapping in prelim test: 3438
Number of HSP's gapped (non-prelim): 109
length of query: 714
length of database: 18,247,518
effective HSP length: 109
effective length of query: 605
effective length of database: 14,120,124
effective search space: 8542675020
effective search space used: 8542675020
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.