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Search of human proteins with 124256474
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo
sapiens]
(766 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo sapiens] 1597 0.0
gi|124256476 diacylglycerol kinase gamma isoform 1 [Homo sapiens] 1583 0.0
gi|124256482 diacylglycerol kinase gamma isoform 3 [Homo sapiens] 1475 0.0
gi|22027632 diacylglycerol kinase, beta isoform 1 [Homo sapiens] 966 0.0
gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo sapiens] 927 0.0
gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 742 0.0
gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 742 0.0
gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 742 0.0
gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 742 0.0
gi|157688564 diacylglycerol kinase zeta isoform 4 [Homo sapiens] 253 5e-67
gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens] 253 5e-67
gi|4758156 diacylglycerol kinase, iota [Homo sapiens] 251 1e-66
gi|41872507 diacylglycerol kinase zeta isoform 2 [Homo sapiens] 249 5e-66
gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens] 249 5e-66
gi|4503313 diacylglycerol kinase epsilon [Homo sapiens] 245 1e-64
gi|40806175 diacylglycerol kinase, theta [Homo sapiens] 205 1e-52
gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens] 164 4e-40
gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens] 164 4e-40
gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo ... 164 4e-40
gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo ... 164 4e-40
gi|62000702 diacylglycerol kinase kappa [Homo sapiens] 135 2e-31
gi|13384594 protein kinase C, gamma [Homo sapiens] 61 3e-09
gi|5453976 protein kinase C, theta [Homo sapiens] 59 2e-08
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 57 8e-08
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 57 8e-08
gi|28557781 protein kinase C, eta [Homo sapiens] 53 9e-07
gi|47157325 protein kinase C, delta [Homo sapiens] 53 9e-07
gi|31377782 protein kinase C, delta [Homo sapiens] 53 9e-07
gi|4506067 protein kinase C, alpha [Homo sapiens] 53 9e-07
gi|4885563 protein kinase C, epsilon [Homo sapiens] 52 2e-06
>gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo sapiens]
Length = 766
Score = 1597 bits (4134), Expect = 0.0
Identities = 766/766 (100%), Positives = 766/766 (100%)
Query: 1 MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMR 60
MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMR
Sbjct: 1 MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMR 60
Query: 61 AYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATKADEAC 120
AYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATKADEAC
Sbjct: 61 AYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATKADEAC 120
Query: 121 APDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDKL 180
APDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDKL
Sbjct: 121 APDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDKL 180
Query: 181 EFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGFV 240
EFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGFV
Sbjct: 181 EFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGFV 240
Query: 241 SLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGL 300
SLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGL
Sbjct: 241 SLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGL 300
Query: 301 CCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQS 360
CCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQS
Sbjct: 301 CCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQS 360
Query: 361 VTARHCVWCRMTFHRKCELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGEL 420
VTARHCVWCRMTFHRKCELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGEL
Sbjct: 361 VTARHCVWCRMTFHRKCELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGEL 420
Query: 421 VMQYKIIPTPGTHPLLVLVNPKSGGRQGERLNFFRDTPDFRVLACGGDGTVGWILDCIDK 480
VMQYKIIPTPGTHPLLVLVNPKSGGRQGERLNFFRDTPDFRVLACGGDGTVGWILDCIDK
Sbjct: 421 VMQYKIIPTPGTHPLLVLVNPKSGGRQGERLNFFRDTPDFRVLACGGDGTVGWILDCIDK 480
Query: 481 ANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPR 540
ANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPR
Sbjct: 481 ANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPR 540
Query: 541 EEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETF 600
EEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETF
Sbjct: 541 EEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETF 600
Query: 601 AATCKKLHDHIELECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRK 660
AATCKKLHDHIELECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRK
Sbjct: 601 AATCKKLHDHIELECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRK 660
Query: 661 GVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLP 720
GVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLP
Sbjct: 661 GVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLP 720
Query: 721 MQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSSFFSLRRKSRSKD 766
MQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSSFFSLRRKSRSKD
Sbjct: 721 MQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSSFFSLRRKSRSKD 766
>gi|124256476 diacylglycerol kinase gamma isoform 1 [Homo sapiens]
Length = 791
Score = 1583 bits (4098), Expect = 0.0
Identities = 766/791 (96%), Positives = 766/791 (96%), Gaps = 25/791 (3%)
Query: 1 MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMR 60
MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMR
Sbjct: 1 MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMR 60
Query: 61 AYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATKADEAC 120
AYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATKADEAC
Sbjct: 61 AYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATKADEAC 120
Query: 121 APDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDKL 180
APDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDKL
Sbjct: 121 APDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDKL 180
Query: 181 EFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGFV 240
EFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGFV
Sbjct: 181 EFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGFV 240
Query: 241 SLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGL 300
SLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGL
Sbjct: 241 SLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGL 300
Query: 301 CCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQS 360
CCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQS
Sbjct: 301 CCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQS 360
Query: 361 VTARHCVWCRMTFHRKCELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGEL 420
VTARHCVWCRMTFHRKCELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGEL
Sbjct: 361 VTARHCVWCRMTFHRKCELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGEL 420
Query: 421 VMQYKIIPTPGTHPLLVLVNPKSGGRQGER-------------------------LNFFR 455
VMQYKIIPTPGTHPLLVLVNPKSGGRQGER LNFFR
Sbjct: 421 VMQYKIIPTPGTHPLLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFR 480
Query: 456 DTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSL 515
DTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSL
Sbjct: 481 DTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSL 540
Query: 516 TKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMRE 575
TKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMRE
Sbjct: 541 TKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMRE 600
Query: 576 KHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNI 635
KHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNI
Sbjct: 601 KHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNI 660
Query: 636 PSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIY 695
PSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIY
Sbjct: 661 PSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIY 720
Query: 696 TGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSSF 755
TGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSSF
Sbjct: 721 TGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSSF 780
Query: 756 FSLRRKSRSKD 766
FSLRRKSRSKD
Sbjct: 781 FSLRRKSRSKD 791
>gi|124256482 diacylglycerol kinase gamma isoform 3 [Homo sapiens]
Length = 752
Score = 1475 bits (3819), Expect = 0.0
Identities = 727/791 (91%), Positives = 727/791 (91%), Gaps = 64/791 (8%)
Query: 1 MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMR 60
MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMR
Sbjct: 1 MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMR 60
Query: 61 AYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATKADEAC 120
AYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATKADEAC
Sbjct: 61 AYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATKADEAC 120
Query: 121 APDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDKL 180
APDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDKL
Sbjct: 121 APDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDKL 180
Query: 181 EFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGFV 240
EFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGFV
Sbjct: 181 EFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGFV 240
Query: 241 SLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGL 300
SLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGL
Sbjct: 241 SLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGL 300
Query: 301 CCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQS 360
CCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGE
Sbjct: 301 CCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGE--------------------------- 333
Query: 361 VTARHCVWCRMTFHRKCELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGEL 420
FHRKCELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGEL
Sbjct: 334 ------------FHRKCELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGEL 381
Query: 421 VMQYKIIPTPGTHPLLVLVNPKSGGRQGER-------------------------LNFFR 455
VMQYKIIPTPGTHPLLVLVNPKSGGRQGER LNFFR
Sbjct: 382 VMQYKIIPTPGTHPLLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFR 441
Query: 456 DTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSL 515
DTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSL
Sbjct: 442 DTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSL 501
Query: 516 TKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMRE 575
TKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMRE
Sbjct: 502 TKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMRE 561
Query: 576 KHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNI 635
KHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNI
Sbjct: 562 KHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNI 621
Query: 636 PSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIY 695
PSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIY
Sbjct: 622 PSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIY 681
Query: 696 TGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSSF 755
TGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSSF
Sbjct: 682 TGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSSF 741
Query: 756 FSLRRKSRSKD 766
FSLRRKSRSKD
Sbjct: 742 FSLRRKSRSKD 752
>gi|22027632 diacylglycerol kinase, beta isoform 1 [Homo sapiens]
Length = 804
Score = 966 bits (2496), Expect = 0.0
Identities = 478/833 (57%), Positives = 582/833 (69%), Gaps = 105/833 (12%)
Query: 3 EERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDP-------HEPISYDVF 55
+E+W L+P EF QLQKY+EYS+KK+KD L EF+ G L +Y+P ++ I ++ F
Sbjct: 4 QEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGF 63
Query: 56 KLFMRAYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATK 115
KLFM+ +LE +LP + HLF++FS K H + ++ A S + T
Sbjct: 64 KLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTS 123
Query: 116 ADEACAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGR 175
C+P+ V++LKD+VCYLSLLE GR
Sbjct: 124 PANTCSPE----------------------------------VIHLKDIVCYLSLLERGR 149
Query: 176 PQDKLEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYD 235
P+DKLEFMFRLYD+D NG LD +E++ I++QM+H+A+YLEWD TEL PIL EM++ +DYD
Sbjct: 150 PEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYLEWDVTELNPILHEMMEEIDYD 209
Query: 236 RDGFVSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGV 295
DG VSL+EW+ GGMTTIPLLVLLG++++ K DG+H W +KHF KP YCN C ML+GV
Sbjct: 210 HDGTVSLEEWIQGGMTTIPLLVLLGLENN-VKDDGQHVWRLKHFNKPAYCNLCLNMLIGV 268
Query: 296 RKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSI 355
KQGLCC++CKYTVHERCV+R P C+KTY K+KR+ +VM H WVEGN KCD+CHK++
Sbjct: 269 GKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVMHHYWVEGNCPTKCDKCHKTV 328
Query: 356 KCYQSVTARHCVWCRMTFHRKC--ELSTLCDGGELRDHILLPTSICPIT----------- 402
KCYQ +T HCVWC++T H KC L CD G L+DHIL PT+ICP+
Sbjct: 329 KCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSV 388
Query: 403 ---------RDRPGEKSDGCVSAKGELVMQ---------YKIIPTPGTHPLLVLVNPKSG 444
+++ G + V K ++ ++ P PGTHPLLV VNPKSG
Sbjct: 389 PEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSG 448
Query: 445 GRQGER-------------------------LNFFRDTPDFRVLACGGDGTVGWILDCID 479
G+QGER LNFFRD PDFRVLACGGDGTVGW+LDCI+
Sbjct: 449 GKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIE 508
Query: 480 KANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIP 539
KAN KHPPVA+LPLGTGNDLARCLRWGGGYEG +L KILKDIE S +MLDRW EVIP
Sbjct: 509 KANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIP 568
Query: 540 REEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSET 599
++ E GD VPYSI+NNYFSIGVDASIAHRFH+MREKHPEKFNSRMKNK WYFEFGTSET
Sbjct: 569 NDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSET 628
Query: 600 FAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESR 659
F+ATCKKLH+ +E+ECDGV +DL NI LEGIAILNIPSM+GG+NLWGE+KK R+ R +
Sbjct: 629 FSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEK 688
Query: 660 KG------VTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTI 713
KG VTD KELKF QDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQC+ V I
Sbjct: 689 KGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVI 748
Query: 714 RTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSSFF-SLRRKSRSK 765
RT+K LPMQ+DGEPWMQ CTIKITHKNQAPM+MGPP K+ F SL +++R++
Sbjct: 749 RTSKSLPMQIDGEPWMQTPCTIKITHKNQAPMLMGPPPKTGLFCSLVKRTRNR 801
>gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo sapiens]
Length = 773
Score = 927 bits (2397), Expect = 0.0
Identities = 458/802 (57%), Positives = 556/802 (69%), Gaps = 104/802 (12%)
Query: 3 EERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDP-------HEPISYDVF 55
+E+W L+P EF QLQKY+EYS+KK+KD L EF+ G L +Y+P ++ I ++ F
Sbjct: 4 QEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGF 63
Query: 56 KLFMRAYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATK 115
KLFM+ +LE +LP + HLF++FS K H + ++ A S + T
Sbjct: 64 KLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTS 123
Query: 116 ADEACAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGR 175
C+P+ V++LKD+VCYLSLLE GR
Sbjct: 124 PANTCSPE----------------------------------VIHLKDIVCYLSLLERGR 149
Query: 176 PQDKLEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYD 235
P+DKLEFMFRLYD+D NG LD +E++ I++QM+H+A+YLEWD TEL PIL EM++ +DYD
Sbjct: 150 PEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYLEWDVTELNPILHEMMEEIDYD 209
Query: 236 RDGFVSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGV 295
DG VSL+EW+ GGMTTIPLLVLLG++++ K DG+H W +KHF KP YCN C ML+GV
Sbjct: 210 HDGTVSLEEWIQGGMTTIPLLVLLGLENN-VKDDGQHVWRLKHFNKPAYCNLCLNMLIGV 268
Query: 296 RKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSI 355
KQGLCC++CKYTVHERCV+R P C+KTY K+KR+ +VM H WVEGN KCD+CHK++
Sbjct: 269 GKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVMHHYWVEGNCPTKCDKCHKTV 328
Query: 356 KCYQSVTARHCVWCRMTFHRKC--ELSTLCDGGELRDHILLPTSICPIT----------- 402
KCYQ +T HCVWC++T H KC L CD G L+DHIL PT+ICP+
Sbjct: 329 KCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSV 388
Query: 403 ---------RDRPGEKSDGCVSAKGELVMQ---------YKIIPTPGTHPLLVLVNPKSG 444
+++ G + V K ++ ++ P PGTHPLLV VNPKSG
Sbjct: 389 PEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSG 448
Query: 445 GRQGER-------------------------LNFFRDTPDFRVLACGGDGTVGWILDCID 479
G+QGER LNFFRD PDFRVLACGGDGTVGW+LDCI+
Sbjct: 449 GKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIE 508
Query: 480 KANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIP 539
KAN KHPPVA+LPLGTGNDLARCLRWGGGYEG +L KILKDIE S +MLDRW EVIP
Sbjct: 509 KANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIP 568
Query: 540 REEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSET 599
++ E GD VPYSI+NNYFSIGVDASIAHRFH+MREKHPEKFNSRMKNK WYFEFGTSET
Sbjct: 569 NDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSET 628
Query: 600 FAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESR 659
F+ATCKKLH+ +E+ECDGV +DL NI LEGIAILNIPSM+GG+NLWGE+KK R+ R +
Sbjct: 629 FSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEK 688
Query: 660 KG------VTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTI 713
KG VTD KELKF QDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQC+ V I
Sbjct: 689 KGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVI 748
Query: 714 RTNKLLPMQVDGEPWMQPCCTI 735
RT+K LPMQ+DGEPWMQ CT+
Sbjct: 749 RTSKSLPMQIDGEPWMQTPCTV 770
>gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 742 bits (1915), Expect = 0.0
Identities = 396/798 (49%), Positives = 501/798 (62%), Gaps = 110/798 (13%)
Query: 1 MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMR 60
M +ER + ++P +F QLQKY EYS+KK+ D L F E G + +Y + I Y+ F+ F++
Sbjct: 1 MAKERGL-ISPSDFAQLQKYMEYSTKKVSDVLKLF-EDGEMAKYVQGDAIGYEGFQQFLK 58
Query: 61 AYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADT-NIQNADNATKADEA 119
++L PRH S + S +T + N N TK
Sbjct: 59 --------------IYLEVDNVPRH---------LSLALFQSFETGHCLNETNVTK---- 91
Query: 120 CAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDK 179
VV L DV CY SLLE GRP+DK
Sbjct: 92 -------------------------------------DVVCLNDVSCYFSLLEGGRPEDK 114
Query: 180 LEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGF 239
LEF F+LYD+D NG+LD +E+D I+ QM+ +A+YL+WD +ELRPIL+EM++ +DYD G
Sbjct: 115 LEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGS 174
Query: 240 VSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQG 299
VS EWV G TT+PLLVLLG++ + K DG+H W K F +P YCN C + G+ KQG
Sbjct: 175 VSQAEWVRAGATTVPLLVLLGLEMT-LKDDGQHMWRPKRFPRPVYCNLCESSI-GLGKQG 232
Query: 300 LCCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGN-SSVKCDRCHKSIKCY 358
L C CKYTVH++C + +P V TY+K+++ V H WV G S +CDRC K I+ Y
Sbjct: 233 LSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIY 292
Query: 359 QSVTARHCVWCRMTFHRKC--ELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSA 416
S+T HCVWC + H C + CD G LRDHIL P+SI P ++ + S
Sbjct: 293 HSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQ 352
Query: 417 K--GELVMQ----YKIIPTPGTHPLLVLVNPKSGGRQGER-------------------- 450
K +L + +I P P THPLLV VNPKSGG+QG+R
Sbjct: 353 KTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKD 412
Query: 451 -----LNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLR 505
L F+D PD R+L CGGDGTVGWIL+ IDKAN PPVAVLPLGTGNDLARCLR
Sbjct: 413 GPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLR 472
Query: 506 WGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDAS 565
WGGGYEG +L KILKD+E S +V +DRW +EVIP++ E D VP+ I+NNYFSIGVDAS
Sbjct: 473 WGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDAS 532
Query: 566 IAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNI 625
IAHRFH+MREK+PEKFNSRMKNKLWYFEF TSE+ +TCKKL + + +E G +DLSN+
Sbjct: 533 IAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNL 592
Query: 626 FLEGIAILNIPSMYGGTNLWGENKKNRA-------VIRESRKGVTDPKELKFCVQDLSDQ 678
LEGIA+LNIPSM+GG+NLWG+ ++ + + K +TDP LK CV DLSD+
Sbjct: 593 SLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDK 652
Query: 679 LLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKIT 738
LEVVGLEGA+EMGQIYT LK+AGRRLA+C+ +T T K LPMQ+DGEPWMQ CTIKIT
Sbjct: 653 RLEVVGLEGAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKIT 712
Query: 739 HKNQAPMMMGPPQKSSFF 756
HKNQ PM+MGPP +S+ F
Sbjct: 713 HKNQMPMLMGPPPRSTNF 730
>gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 742 bits (1915), Expect = 0.0
Identities = 396/798 (49%), Positives = 501/798 (62%), Gaps = 110/798 (13%)
Query: 1 MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMR 60
M +ER + ++P +F QLQKY EYS+KK+ D L F E G + +Y + I Y+ F+ F++
Sbjct: 1 MAKERGL-ISPSDFAQLQKYMEYSTKKVSDVLKLF-EDGEMAKYVQGDAIGYEGFQQFLK 58
Query: 61 AYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADT-NIQNADNATKADEA 119
++L PRH S + S +T + N N TK
Sbjct: 59 --------------IYLEVDNVPRH---------LSLALFQSFETGHCLNETNVTK---- 91
Query: 120 CAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDK 179
VV L DV CY SLLE GRP+DK
Sbjct: 92 -------------------------------------DVVCLNDVSCYFSLLEGGRPEDK 114
Query: 180 LEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGF 239
LEF F+LYD+D NG+LD +E+D I+ QM+ +A+YL+WD +ELRPIL+EM++ +DYD G
Sbjct: 115 LEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGS 174
Query: 240 VSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQG 299
VS EWV G TT+PLLVLLG++ + K DG+H W K F +P YCN C + G+ KQG
Sbjct: 175 VSQAEWVRAGATTVPLLVLLGLEMT-LKDDGQHMWRPKRFPRPVYCNLCESSI-GLGKQG 232
Query: 300 LCCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGN-SSVKCDRCHKSIKCY 358
L C CKYTVH++C + +P V TY+K+++ V H WV G S +CDRC K I+ Y
Sbjct: 233 LSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIY 292
Query: 359 QSVTARHCVWCRMTFHRKC--ELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSA 416
S+T HCVWC + H C + CD G LRDHIL P+SI P ++ + S
Sbjct: 293 HSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQ 352
Query: 417 K--GELVMQ----YKIIPTPGTHPLLVLVNPKSGGRQGER-------------------- 450
K +L + +I P P THPLLV VNPKSGG+QG+R
Sbjct: 353 KTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKD 412
Query: 451 -----LNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLR 505
L F+D PD R+L CGGDGTVGWIL+ IDKAN PPVAVLPLGTGNDLARCLR
Sbjct: 413 GPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLR 472
Query: 506 WGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDAS 565
WGGGYEG +L KILKD+E S +V +DRW +EVIP++ E D VP+ I+NNYFSIGVDAS
Sbjct: 473 WGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDAS 532
Query: 566 IAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNI 625
IAHRFH+MREK+PEKFNSRMKNKLWYFEF TSE+ +TCKKL + + +E G +DLSN+
Sbjct: 533 IAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNL 592
Query: 626 FLEGIAILNIPSMYGGTNLWGENKKNRA-------VIRESRKGVTDPKELKFCVQDLSDQ 678
LEGIA+LNIPSM+GG+NLWG+ ++ + + K +TDP LK CV DLSD+
Sbjct: 593 SLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDK 652
Query: 679 LLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKIT 738
LEVVGLEGA+EMGQIYT LK+AGRRLA+C+ +T T K LPMQ+DGEPWMQ CTIKIT
Sbjct: 653 RLEVVGLEGAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKIT 712
Query: 739 HKNQAPMMMGPPQKSSFF 756
HKNQ PM+MGPP +S+ F
Sbjct: 713 HKNQMPMLMGPPPRSTNF 730
>gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 742 bits (1915), Expect = 0.0
Identities = 396/798 (49%), Positives = 501/798 (62%), Gaps = 110/798 (13%)
Query: 1 MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMR 60
M +ER + ++P +F QLQKY EYS+KK+ D L F E G + +Y + I Y+ F+ F++
Sbjct: 1 MAKERGL-ISPSDFAQLQKYMEYSTKKVSDVLKLF-EDGEMAKYVQGDAIGYEGFQQFLK 58
Query: 61 AYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADT-NIQNADNATKADEA 119
++L PRH S + S +T + N N TK
Sbjct: 59 --------------IYLEVDNVPRH---------LSLALFQSFETGHCLNETNVTK---- 91
Query: 120 CAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDK 179
VV L DV CY SLLE GRP+DK
Sbjct: 92 -------------------------------------DVVCLNDVSCYFSLLEGGRPEDK 114
Query: 180 LEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGF 239
LEF F+LYD+D NG+LD +E+D I+ QM+ +A+YL+WD +ELRPIL+EM++ +DYD G
Sbjct: 115 LEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGS 174
Query: 240 VSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQG 299
VS EWV G TT+PLLVLLG++ + K DG+H W K F +P YCN C + G+ KQG
Sbjct: 175 VSQAEWVRAGATTVPLLVLLGLEMT-LKDDGQHMWRPKRFPRPVYCNLCESSI-GLGKQG 232
Query: 300 LCCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGN-SSVKCDRCHKSIKCY 358
L C CKYTVH++C + +P V TY+K+++ V H WV G S +CDRC K I+ Y
Sbjct: 233 LSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIY 292
Query: 359 QSVTARHCVWCRMTFHRKC--ELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSA 416
S+T HCVWC + H C + CD G LRDHIL P+SI P ++ + S
Sbjct: 293 HSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQ 352
Query: 417 K--GELVMQ----YKIIPTPGTHPLLVLVNPKSGGRQGER-------------------- 450
K +L + +I P P THPLLV VNPKSGG+QG+R
Sbjct: 353 KTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKD 412
Query: 451 -----LNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLR 505
L F+D PD R+L CGGDGTVGWIL+ IDKAN PPVAVLPLGTGNDLARCLR
Sbjct: 413 GPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLR 472
Query: 506 WGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDAS 565
WGGGYEG +L KILKD+E S +V +DRW +EVIP++ E D VP+ I+NNYFSIGVDAS
Sbjct: 473 WGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDAS 532
Query: 566 IAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNI 625
IAHRFH+MREK+PEKFNSRMKNKLWYFEF TSE+ +TCKKL + + +E G +DLSN+
Sbjct: 533 IAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNL 592
Query: 626 FLEGIAILNIPSMYGGTNLWGENKKNRA-------VIRESRKGVTDPKELKFCVQDLSDQ 678
LEGIA+LNIPSM+GG+NLWG+ ++ + + K +TDP LK CV DLSD+
Sbjct: 593 SLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDK 652
Query: 679 LLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKIT 738
LEVVGLEGA+EMGQIYT LK+AGRRLA+C+ +T T K LPMQ+DGEPWMQ CTIKIT
Sbjct: 653 RLEVVGLEGAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKIT 712
Query: 739 HKNQAPMMMGPPQKSSFF 756
HKNQ PM+MGPP +S+ F
Sbjct: 713 HKNQMPMLMGPPPRSTNF 730
>gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 742 bits (1915), Expect = 0.0
Identities = 396/798 (49%), Positives = 501/798 (62%), Gaps = 110/798 (13%)
Query: 1 MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMR 60
M +ER + ++P +F QLQKY EYS+KK+ D L F E G + +Y + I Y+ F+ F++
Sbjct: 1 MAKERGL-ISPSDFAQLQKYMEYSTKKVSDVLKLF-EDGEMAKYVQGDAIGYEGFQQFLK 58
Query: 61 AYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADT-NIQNADNATKADEA 119
++L PRH S + S +T + N N TK
Sbjct: 59 --------------IYLEVDNVPRH---------LSLALFQSFETGHCLNETNVTK---- 91
Query: 120 CAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDK 179
VV L DV CY SLLE GRP+DK
Sbjct: 92 -------------------------------------DVVCLNDVSCYFSLLEGGRPEDK 114
Query: 180 LEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGF 239
LEF F+LYD+D NG+LD +E+D I+ QM+ +A+YL+WD +ELRPIL+EM++ +DYD G
Sbjct: 115 LEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGS 174
Query: 240 VSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQG 299
VS EWV G TT+PLLVLLG++ + K DG+H W K F +P YCN C + G+ KQG
Sbjct: 175 VSQAEWVRAGATTVPLLVLLGLEMT-LKDDGQHMWRPKRFPRPVYCNLCESSI-GLGKQG 232
Query: 300 LCCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGN-SSVKCDRCHKSIKCY 358
L C CKYTVH++C + +P V TY+K+++ V H WV G S +CDRC K I+ Y
Sbjct: 233 LSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIY 292
Query: 359 QSVTARHCVWCRMTFHRKC--ELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSA 416
S+T HCVWC + H C + CD G LRDHIL P+SI P ++ + S
Sbjct: 293 HSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQ 352
Query: 417 K--GELVMQ----YKIIPTPGTHPLLVLVNPKSGGRQGER-------------------- 450
K +L + +I P P THPLLV VNPKSGG+QG+R
Sbjct: 353 KTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKD 412
Query: 451 -----LNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLR 505
L F+D PD R+L CGGDGTVGWIL+ IDKAN PPVAVLPLGTGNDLARCLR
Sbjct: 413 GPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLR 472
Query: 506 WGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDAS 565
WGGGYEG +L KILKD+E S +V +DRW +EVIP++ E D VP+ I+NNYFSIGVDAS
Sbjct: 473 WGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDAS 532
Query: 566 IAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNI 625
IAHRFH+MREK+PEKFNSRMKNKLWYFEF TSE+ +TCKKL + + +E G +DLSN+
Sbjct: 533 IAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNL 592
Query: 626 FLEGIAILNIPSMYGGTNLWGENKKNRA-------VIRESRKGVTDPKELKFCVQDLSDQ 678
LEGIA+LNIPSM+GG+NLWG+ ++ + + K +TDP LK CV DLSD+
Sbjct: 593 SLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDK 652
Query: 679 LLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKIT 738
LEVVGLEGA+EMGQIYT LK+AGRRLA+C+ +T T K LPMQ+DGEPWMQ CTIKIT
Sbjct: 653 RLEVVGLEGAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKIT 712
Query: 739 HKNQAPMMMGPPQKSSFF 756
HKNQ PM+MGPP +S+ F
Sbjct: 713 HKNQMPMLMGPPPRSTNF 730
>gi|157688564 diacylglycerol kinase zeta isoform 4 [Homo sapiens]
Length = 1117
Score = 253 bits (646), Expect = 5e-67
Identities = 185/573 (32%), Positives = 260/573 (45%), Gaps = 108/573 (18%)
Query: 261 MDDSGSKGDGRHAWTMKHFKKPTYCNFCHI--------MLMGVRKQGLCCTYCKYTVHER 312
+D S S G H W F+ +FC++ ML V ++ C CK VH
Sbjct: 276 VDWSESATYGEHIW----FETNVSGDFCYVGEQYCVARMLKSVSRRK--CAACKIVVHTP 329
Query: 313 CVS-------RNIPGCVKTYSKAKRSGEVMQHAWVEGN-SSVKCDRCHKSIKCY-----Q 359
C+ R P ++ S+ R ++H WV KC C K + +
Sbjct: 330 CIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSK 389
Query: 360 SVTARHCVWCRMTFHRKC------ELSTLCDGGELRDHILLPTSICPITRDRPGEKSD-- 411
+ A C WC+ +H K ++ C G ++ PT I R + K+
Sbjct: 390 EIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKK 449
Query: 412 -------GCVSAKGELVMQYK---IIPTPG--THPLLVLVNPKSGGRQG----------- 448
S KG +++ I PTP PLLV VNPKSGG QG
Sbjct: 450 KKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYL 509
Query: 449 --------------ERLNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPL 494
E L +R + R+LACGGDGTVGWIL +D+ PPVA+LPL
Sbjct: 510 NPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPL 569
Query: 495 GTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPR-----EEVENG--D 547
GTGNDLAR L WGGGY ++KIL +E+ +V LDRW L P E+ + G D
Sbjct: 570 GTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATD 629
Query: 548 QVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKL 607
++P + NNYFS+G DA + FH RE +PEKFNSR +NK++Y S+ + K L
Sbjct: 630 RLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDL 689
Query: 608 HDHIELECDGVGV--DLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDP 665
HI + CDG+ + + ++ + + LNIP GT WG ++
Sbjct: 690 AKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHH------------- 736
Query: 666 KELKFCVQDLSDQLLEVVGLE----GAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPM 721
F Q D LEV+G A+++G G RL QC V + T+K +P+
Sbjct: 737 ---DFEPQRHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREVVLTTSKAIPV 786
Query: 722 QVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSS 754
QVDGEP I+I +NQA M+ ++S+
Sbjct: 787 QVDGEPCKLAASRIRIALRNQATMVQKAKRRSA 819
>gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens]
Length = 945
Score = 253 bits (646), Expect = 5e-67
Identities = 185/573 (32%), Positives = 260/573 (45%), Gaps = 108/573 (18%)
Query: 261 MDDSGSKGDGRHAWTMKHFKKPTYCNFCHI--------MLMGVRKQGLCCTYCKYTVHER 312
+D S S G H W F+ +FC++ ML V ++ C CK VH
Sbjct: 104 VDWSESATYGEHIW----FETNVSGDFCYVGEQYCVARMLKSVSRRK--CAACKIVVHTP 157
Query: 313 CVS-------RNIPGCVKTYSKAKRSGEVMQHAWVEGN-SSVKCDRCHKSIKCY-----Q 359
C+ R P ++ S+ R ++H WV KC C K + +
Sbjct: 158 CIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSK 217
Query: 360 SVTARHCVWCRMTFHRKC------ELSTLCDGGELRDHILLPTSICPITRDRPGEKSD-- 411
+ A C WC+ +H K ++ C G ++ PT I R + K+
Sbjct: 218 EIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKK 277
Query: 412 -------GCVSAKGELVMQYK---IIPTPG--THPLLVLVNPKSGGRQG----------- 448
S KG +++ I PTP PLLV VNPKSGG QG
Sbjct: 278 KKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYL 337
Query: 449 --------------ERLNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPL 494
E L +R + R+LACGGDGTVGWIL +D+ PPVA+LPL
Sbjct: 338 NPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPL 397
Query: 495 GTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPR-----EEVENG--D 547
GTGNDLAR L WGGGY ++KIL +E+ +V LDRW L P E+ + G D
Sbjct: 398 GTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATD 457
Query: 548 QVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKL 607
++P + NNYFS+G DA + FH RE +PEKFNSR +NK++Y S+ + K L
Sbjct: 458 RLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDL 517
Query: 608 HDHIELECDGVGV--DLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDP 665
HI + CDG+ + + ++ + + LNIP GT WG ++
Sbjct: 518 AKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHH------------- 564
Query: 666 KELKFCVQDLSDQLLEVVGLE----GAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPM 721
F Q D LEV+G A+++G G RL QC V + T+K +P+
Sbjct: 565 ---DFEPQRHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREVVLTTSKAIPV 614
Query: 722 QVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSS 754
QVDGEP I+I +NQA M+ ++S+
Sbjct: 615 QVDGEPCKLAASRIRIALRNQATMVQKAKRRSA 647
>gi|4758156 diacylglycerol kinase, iota [Homo sapiens]
Length = 1065
Score = 251 bits (642), Expect = 1e-66
Identities = 172/520 (33%), Positives = 238/520 (45%), Gaps = 86/520 (16%)
Query: 302 CTYCKYTVHERCVSRNIP---GCVKTY----SKAKRSGEVMQHAWVEGNSSVKCDRCHKS 354
C CK VH C+ + C T+ S++ R V H KC +C K
Sbjct: 210 CAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKG 269
Query: 355 IKCYQS-----VTARHCVWCRMTFHRKCELSTL------CDGGELRDHILLPTSICPITR 403
+ S + A C WC+ FH K L C G I+ PT I + +
Sbjct: 270 FQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKK 329
Query: 404 DRPGEKSDGCVSAKGELVMQ----------------YKIIPTPGTHPLLVLVNPKSGGRQ 447
+ K+ + + K I +P PLLV VNPKSGG Q
Sbjct: 330 PQNSLKASNRKKKRTSFKRKASKRGMEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQ 389
Query: 448 GER-------------------------LNFFRDTPDFRVLACGGDGTVGWILDCIDKAN 482
G + L +R P+ R+LACGGDGTVGWIL +D+
Sbjct: 390 GTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSILDELQ 449
Query: 483 FAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEV----- 537
+ PPV VLPLGTGNDLAR L WGGGY ++KIL +E +V LDRW+L V
Sbjct: 450 LSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDGTVVQLDRWNLHVERNPD 509
Query: 538 IPREEVENG-DQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGT 596
+P EE+E+G ++P ++ NNYFS+G DA + FH RE +PEKFNSR +NK++Y
Sbjct: 510 LPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAF 569
Query: 597 SETFAATCKKLHDHIELECDGVGV--DLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAV 654
S+ + + L H+++ CDG + + + + I LNIP GT WG +
Sbjct: 570 SDFLQRSSRDLSKHVKVVCDGTDLTPKIQELKFQCIVFLNIPRYCAGTMPWGNPGDHH-- 627
Query: 655 IRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTIR 714
F Q D +EV+G A + + G G RL QC V +
Sbjct: 628 --------------DFEPQRHDDGYIEVIGFTMA-SLAALQVG--GHGERLHQCREVMLL 670
Query: 715 TNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSS 754
T K +PMQVDGEP I+I+ +NQA M+ +++S
Sbjct: 671 TYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTS 710
>gi|41872507 diacylglycerol kinase zeta isoform 2 [Homo sapiens]
Length = 929
Score = 249 bits (637), Expect = 5e-66
Identities = 182/572 (31%), Positives = 257/572 (44%), Gaps = 105/572 (18%)
Query: 261 MDDSGSKGDGRHAWTMKHFKKPTYCNFCHI-------MLMGVRKQGLCCTYCKYTVHERC 313
+D S S G H W F+ +FC++ ++ C CK VH C
Sbjct: 87 VDWSESATYGEHIW----FETNVSGDFCYVGEQYCVARMLQKSVSRRKCAACKIVVHTPC 142
Query: 314 VS-------RNIPGCVKTYSKAKRSGEVMQHAWVEGN-SSVKCDRCHKSIKCY-----QS 360
+ R P ++ S+ R ++H WV KC C K + +
Sbjct: 143 IEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKE 202
Query: 361 VTARHCVWCRMTFHRKC------ELSTLCDGGELRDHILLPTSICPITRDRPGEKSD--- 411
+ A C WC+ +H K ++ C G ++ PT I R + K+
Sbjct: 203 IVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKK 262
Query: 412 ------GCVSAKGELVMQYK---IIPTPG--THPLLVLVNPKSGGRQG------------ 448
S KG +++ I PTP PLLV VNPKSGG QG
Sbjct: 263 KRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLN 322
Query: 449 -------------ERLNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLG 495
E L +R + R+LACGGDGTVGWIL +D+ PPVA+LPLG
Sbjct: 323 PRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLG 382
Query: 496 TGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPR-----EEVENG--DQ 548
TGNDLAR L WGGGY ++KIL +E+ +V LDRW L P E+ + G D+
Sbjct: 383 TGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDR 442
Query: 549 VPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLH 608
+P + NNYFS+G DA + FH RE +PEKFNSR +NK++Y S+ + K L
Sbjct: 443 LPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLA 502
Query: 609 DHIELECDGVGV--DLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPK 666
HI + CDG+ + + ++ + + LNIP GT WG ++
Sbjct: 503 KHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHH-------------- 548
Query: 667 ELKFCVQDLSDQLLEVVGLE----GAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQ 722
F Q D LEV+G A+++G G RL QC V + T+K +P+Q
Sbjct: 549 --DFEPQRHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREVVLTTSKAIPVQ 599
Query: 723 VDGEPWMQPCCTIKITHKNQAPMMMGPPQKSS 754
VDGEP I+I +NQA M+ ++S+
Sbjct: 600 VDGEPCKLAASRIRIALRNQATMVQKAKRRSA 631
>gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens]
Length = 895
Score = 249 bits (637), Expect = 5e-66
Identities = 182/572 (31%), Positives = 257/572 (44%), Gaps = 105/572 (18%)
Query: 261 MDDSGSKGDGRHAWTMKHFKKPTYCNFCHI-------MLMGVRKQGLCCTYCKYTVHERC 313
+D S S G H W F+ +FC++ ++ C CK VH C
Sbjct: 53 VDWSESATYGEHIW----FETNVSGDFCYVGEQYCVARMLQKSVSRRKCAACKIVVHTPC 108
Query: 314 VS-------RNIPGCVKTYSKAKRSGEVMQHAWVEGN-SSVKCDRCHKSIKCY-----QS 360
+ R P ++ S+ R ++H WV KC C K + +
Sbjct: 109 IEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKE 168
Query: 361 VTARHCVWCRMTFHRKC------ELSTLCDGGELRDHILLPTSICPITRDRPGEKSD--- 411
+ A C WC+ +H K ++ C G ++ PT I R + K+
Sbjct: 169 IVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKK 228
Query: 412 ------GCVSAKGELVMQYK---IIPTPG--THPLLVLVNPKSGGRQG------------ 448
S KG +++ I PTP PLLV VNPKSGG QG
Sbjct: 229 KRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLN 288
Query: 449 -------------ERLNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLG 495
E L +R + R+LACGGDGTVGWIL +D+ PPVA+LPLG
Sbjct: 289 PRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLG 348
Query: 496 TGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPR-----EEVENG--DQ 548
TGNDLAR L WGGGY ++KIL +E+ +V LDRW L P E+ + G D+
Sbjct: 349 TGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDR 408
Query: 549 VPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLH 608
+P + NNYFS+G DA + FH RE +PEKFNSR +NK++Y S+ + K L
Sbjct: 409 LPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLA 468
Query: 609 DHIELECDGVGV--DLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPK 666
HI + CDG+ + + ++ + + LNIP GT WG ++
Sbjct: 469 KHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHH-------------- 514
Query: 667 ELKFCVQDLSDQLLEVVGLE----GAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQ 722
F Q D LEV+G A+++G G RL QC V + T+K +P+Q
Sbjct: 515 --DFEPQRHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREVVLTTSKAIPVQ 565
Query: 723 VDGEPWMQPCCTIKITHKNQAPMMMGPPQKSS 754
VDGEP I+I +NQA M+ ++S+
Sbjct: 566 VDGEPCKLAASRIRIALRNQATMVQKAKRRSA 597
>gi|4503313 diacylglycerol kinase epsilon [Homo sapiens]
Length = 567
Score = 245 bits (626), Expect = 1e-64
Identities = 183/521 (35%), Positives = 250/521 (47%), Gaps = 81/521 (15%)
Query: 271 RHAWTMKH-FKKPTYCNFC--HIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSK 327
+H W F +PTYC C HI+ QG C C V E C+ +
Sbjct: 59 KHGWRDTDLFSQPTYCCVCAQHIL------QGAFCDCCGLRVDEGCLRKADKRFQCKEIM 112
Query: 328 AKRSGEV---MQHAWVEGNSSV--KCDRCHKSIKCYQSVTARHCVWCRMTFHRKCELSTL 382
K +V M H W+ GN + C C + C + C+WC+ T H +C ++L
Sbjct: 113 LKNDTKVLDAMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMKNSL 172
Query: 383 ----CDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGELVMQYKIIPTPGTHPLLVL 438
CD GE ++ I+ P+ + I + R +K+D V A +L Q+ PL++L
Sbjct: 173 KNEKCDFGEFKNLIIPPSYLTSINQMRKDKKTDYEVLA-SKLGKQWT--------PLIIL 223
Query: 439 VNPKSGGRQGE-RLNFFR------------DTPDF--------------RVLACGGDGTV 471
N +SG GE L FR TP RVL CGGDGTV
Sbjct: 224 ANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCGGDGTV 283
Query: 472 GWILDCID----KANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGG-SLTKILKDIEQSP 526
GW+LD +D K P VAVLPLGTGNDL+ L WG GY G + ++L+++ ++
Sbjct: 284 GWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVMEAD 343
Query: 527 LVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMK 586
+ LDRW ++V + N + MNNYFS+G DA +A FH REK P F+SR+
Sbjct: 344 GIKLDRWKVQV-TNKGYYNLRKPKEFTMNNYFSVGPDALMALNFHAHREKAPSLFSSRIL 402
Query: 587 NKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWG 646
NK Y +GT + CK L+ +ELE DG V L + LEGI +LNI GG LW
Sbjct: 403 NKAVYLFYGTKDCLVQECKDLNKKVELELDGERVALPS--LEGIIVLNIGYWGGGCRLW- 459
Query: 647 ENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLA 706
+G+ D + + D LLEVVG+ G+ QI L + R+
Sbjct: 460 -------------EGMGDE---TYPLARHDDGLLEVVGVYGSFHCAQIQVKLANP-FRIG 502
Query: 707 QCASV-TIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMM 746
Q +V I ++PMQVDGEPW Q CT+ ITHK A M+
Sbjct: 503 QAHTVRLILKCSMMPMQVDGEPWAQGPCTVTITHKTHAMML 543
>gi|40806175 diacylglycerol kinase, theta [Homo sapiens]
Length = 942
Score = 205 bits (522), Expect = 1e-52
Identities = 127/335 (37%), Positives = 173/335 (51%), Gaps = 56/335 (16%)
Query: 430 PGTHPLLVLVNPKSGGRQGERL-------------------------NFFRDTPDFRVLA 464
P + PLLV VNPKSGG +G L + F P FRVL
Sbjct: 584 PDSCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLV 643
Query: 465 CGGDGTVGWILDCIDKANF---AKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKD 521
CGGDGTVGW+L +++ + P VA+LPLGTGNDL R LRWG GY G +L
Sbjct: 644 CGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLLS 703
Query: 522 IEQSPLVMLDRWHLEVIPRE----EVENGDQVPYSI--MNNYFSIGVDASIAHRFHVMRE 575
++++ V++DRW + + E E + D P I M+NY IG+DA ++ FH RE
Sbjct: 704 VDEADAVLMDRWTILLDAHEAGSAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQARE 763
Query: 576 KHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNI 635
+ P KF SR+ NK Y G + + + LH I L+ + V+L +I EG+ +NI
Sbjct: 764 EEPGKFTSRLHNKGVYVRVGLQK--ISHSRSLHKQIRLQVERQEVELPSI--EGLIFINI 819
Query: 636 PSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIY 695
PS G +LWG + R F + D LLEVVG+ G + MGQ+
Sbjct: 820 PSWGSGADLWGSDSDTR-----------------FEKPRMDDGLLEVVGVTGVVHMGQVQ 862
Query: 696 TGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQ 730
GL+S G R+AQ + + K P+QVDGEPW+Q
Sbjct: 863 GGLRS-GIRIAQGSYFRVTLLKATPVQVDGEPWVQ 896
Score = 55.5 bits (132), Expect = 2e-07
Identities = 33/131 (25%), Positives = 51/131 (38%), Gaps = 7/131 (5%)
Query: 272 HAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKAKRS 331
H + + K +C C +L L C C+ +H CV C + + +
Sbjct: 122 HCFGPRGLHKRKFCAVCRKVL---EAPALHCEVCELHLHPDCVPFACSDCRQCHQDGHQD 178
Query: 332 GEVMQHAWVEGN--SSVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCE--LSTLCDGGE 387
+ H W EGN S +C+ C K+ + C WC + H C L+ C G
Sbjct: 179 HDTHHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGR 238
Query: 388 LRDHILLPTSI 398
LR +L P +
Sbjct: 239 LRSLVLPPACV 249
Score = 37.7 bits (86), Expect = 0.040
Identities = 27/107 (25%), Positives = 39/107 (36%), Gaps = 8/107 (7%)
Query: 272 HAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKAKRS 331
H++ KPT+C+ C + G+ G C C + HE+C+ C R
Sbjct: 61 HSFRKVTLTKPTFCHLCSDFIWGL--AGFLCDVCNFMSHEKCLKHVRIPCTSVAPSLVRV 118
Query: 332 GEVMQHAWVEGNSSVK-CDRCHKSIKCYQSVTARHCVWCRMTFHRKC 377
V G K C C K ++ A HC C + H C
Sbjct: 119 -PVAHCFGPRGLHKRKFCAVCRKVLE----APALHCEVCELHLHPDC 160
>gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens]
Length = 1164
Score = 164 bits (414), Expect = 4e-40
Identities = 103/303 (33%), Positives = 136/303 (44%), Gaps = 54/303 (17%)
Query: 270 GRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKA- 328
G H W +PT+CN C L GV GL C CK+ H+RC R C T +
Sbjct: 174 GMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 233
Query: 329 ------KRSGEVMQHAWVEGNS--SVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCE-- 378
G M H W+EGN S KC C K+ + C+WC+ H C+
Sbjct: 234 GKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDL 293
Query: 379 LSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGELVMQYKIIPTPGTHPLLVL 438
+C G+ + I+ P ++ SDG A + PLLV
Sbjct: 294 YHPICPLGQCKVSIIPPIAL-------NSTDSDGFCRATFSFCVS----------PLLVF 336
Query: 439 VNPKSGGRQGER-------------------------LNFFRDTPDFRVLACGGDGTVGW 473
VN KSG QG + L F+ +FR+L CGGDG+VGW
Sbjct: 337 VNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGW 396
Query: 474 ILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGS-LTKILKDIEQSPLVMLDR 532
+L IDK N K + VLPLGTGNDLAR L WGG Y+ + L +IL+ +E++ MLDR
Sbjct: 397 VLSEIDKLNLNKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDR 456
Query: 533 WHL 535
W +
Sbjct: 457 WSI 459
Score = 146 bits (369), Expect = 6e-35
Identities = 83/196 (42%), Positives = 114/196 (58%), Gaps = 21/196 (10%)
Query: 553 IMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIE 612
+MNNYF IG+DA I+ F+ RE+HPEK SR KN +WY GT E + K L ++
Sbjct: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829
Query: 613 LECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCV 672
LECDG + L + L+GIA+LNIPS GGTN WG K++ F
Sbjct: 830 LECDGQYIPLPS--LQGIAVLNIPSYAGGTNFWGGTKEDDI----------------FAA 871
Query: 673 QDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASV--TIRTNKLLPMQVDGEPWMQ 730
D++LEVV + +M+M + +K R+AQC +V TI ++ +P+QVDGE W+Q
Sbjct: 872 PSFDDKILEVVAIFDSMQMA-VSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQ 930
Query: 731 PCCTIKITHKNQAPMM 746
P IKI HKN+A M+
Sbjct: 931 PPGIIKIVHKNRAQML 946
>gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens]
Length = 1220
Score = 164 bits (414), Expect = 4e-40
Identities = 103/303 (33%), Positives = 136/303 (44%), Gaps = 54/303 (17%)
Query: 270 GRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKA- 328
G H W +PT+CN C L GV GL C CK+ H+RC R C T +
Sbjct: 174 GMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 233
Query: 329 ------KRSGEVMQHAWVEGNS--SVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCE-- 378
G M H W+EGN S KC C K+ + C+WC+ H C+
Sbjct: 234 GKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDL 293
Query: 379 LSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGELVMQYKIIPTPGTHPLLVL 438
+C G+ + I+ P ++ SDG A + PLLV
Sbjct: 294 YHPICPLGQCKVSIIPPIAL-------NSTDSDGFCRATFSFCVS----------PLLVF 336
Query: 439 VNPKSGGRQGER-------------------------LNFFRDTPDFRVLACGGDGTVGW 473
VN KSG QG + L F+ +FR+L CGGDG+VGW
Sbjct: 337 VNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGW 396
Query: 474 ILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGS-LTKILKDIEQSPLVMLDR 532
+L IDK N K + VLPLGTGNDLAR L WGG Y+ + L +IL+ +E++ MLDR
Sbjct: 397 VLSEIDKLNLNKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDR 456
Query: 533 WHL 535
W +
Sbjct: 457 WSI 459
Score = 146 bits (369), Expect = 6e-35
Identities = 83/196 (42%), Positives = 114/196 (58%), Gaps = 21/196 (10%)
Query: 553 IMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIE 612
+MNNYF IG+DA I+ F+ RE+HPEK SR KN +WY GT E + K L ++
Sbjct: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829
Query: 613 LECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCV 672
LECDG + L + L+GIA+LNIPS GGTN WG K++ F
Sbjct: 830 LECDGQYIPLPS--LQGIAVLNIPSYAGGTNFWGGTKEDDI----------------FAA 871
Query: 673 QDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASV--TIRTNKLLPMQVDGEPWMQ 730
D++LEVV + +M+M + +K R+AQC +V TI ++ +P+QVDGE W+Q
Sbjct: 872 PSFDDKILEVVAIFDSMQMA-VSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQ 930
Query: 731 PCCTIKITHKNQAPMM 746
P IKI HKN+A M+
Sbjct: 931 PPGIIKIVHKNRAQML 946
>gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo
sapiens]
Length = 1170
Score = 164 bits (414), Expect = 4e-40
Identities = 106/301 (35%), Positives = 134/301 (44%), Gaps = 53/301 (17%)
Query: 270 GRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKA- 328
G H W +PTYCN C L GV GL C CK+ H+RC R C T +
Sbjct: 118 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 177
Query: 329 ------KRSGEVMQHAWVEGNS--SVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCE-- 378
G M H W+EGN S KC C K+ + C+WC+ H C+
Sbjct: 178 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 237
Query: 379 LSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGELVMQYKIIPTPGTHPLLVL 438
L T C G + ++ PT++ I SDG A P T PLLV
Sbjct: 238 LLTKCPLGLCKVSVIPPTALNSID-------SDGFWKAS---------CPPSCTSPLLVF 281
Query: 439 VNPKSGGRQGER-------------------------LNFFRDTPDFRVLACGGDGTVGW 473
VN KSG QG + L F+ FR+L CGGDG+VGW
Sbjct: 282 VNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGW 341
Query: 474 ILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGS-LTKILKDIEQSPLVMLDR 532
+L ID N K + VLPLGTGNDLAR L WG + + L +IL+ +E++ MLDR
Sbjct: 342 VLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDR 401
Query: 533 W 533
W
Sbjct: 402 W 402
Score = 140 bits (354), Expect = 3e-33
Identities = 80/193 (41%), Positives = 112/193 (58%), Gaps = 21/193 (10%)
Query: 553 IMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIE 612
+MNNYF IG+DA I+ F+ R++HPEK SR KN +WY GT E T K L +
Sbjct: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778
Query: 613 LECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCV 672
LECDG + L + L+GIA+LNIPS GGTN WG K++ F
Sbjct: 779 LECDGRPIPLPS--LQGIAVLNIPSYAGGTNFWGGTKEDDT----------------FAA 820
Query: 673 QDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASV--TIRTNKLLPMQVDGEPWMQ 730
D++LEVV + G+M+M + ++ R+AQC +V +I ++ +P+QVDGE W+Q
Sbjct: 821 PSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQ 879
Query: 731 PCCTIKITHKNQA 743
P I+I HKN+A
Sbjct: 880 PPGYIRIVHKNRA 892
>gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo
sapiens]
Length = 1214
Score = 164 bits (414), Expect = 4e-40
Identities = 106/301 (35%), Positives = 134/301 (44%), Gaps = 53/301 (17%)
Query: 270 GRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKA- 328
G H W +PTYCN C L GV GL C CK+ H+RC R C T +
Sbjct: 162 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 221
Query: 329 ------KRSGEVMQHAWVEGNS--SVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCE-- 378
G M H W+EGN S KC C K+ + C+WC+ H C+
Sbjct: 222 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 281
Query: 379 LSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGELVMQYKIIPTPGTHPLLVL 438
L T C G + ++ PT++ I SDG A P T PLLV
Sbjct: 282 LLTKCPLGLCKVSVIPPTALNSID-------SDGFWKAS---------CPPSCTSPLLVF 325
Query: 439 VNPKSGGRQGER-------------------------LNFFRDTPDFRVLACGGDGTVGW 473
VN KSG QG + L F+ FR+L CGGDG+VGW
Sbjct: 326 VNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGW 385
Query: 474 ILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGS-LTKILKDIEQSPLVMLDR 532
+L ID N K + VLPLGTGNDLAR L WG + + L +IL+ +E++ MLDR
Sbjct: 386 VLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDR 445
Query: 533 W 533
W
Sbjct: 446 W 446
Score = 140 bits (354), Expect = 3e-33
Identities = 80/193 (41%), Positives = 112/193 (58%), Gaps = 21/193 (10%)
Query: 553 IMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIE 612
+MNNYF IG+DA I+ F+ R++HPEK SR KN +WY GT E T K L +
Sbjct: 763 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 822
Query: 613 LECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCV 672
LECDG + L + L+GIA+LNIPS GGTN WG K++ F
Sbjct: 823 LECDGRPIPLPS--LQGIAVLNIPSYAGGTNFWGGTKEDDT----------------FAA 864
Query: 673 QDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASV--TIRTNKLLPMQVDGEPWMQ 730
D++LEVV + G+M+M + ++ R+AQC +V +I ++ +P+QVDGE W+Q
Sbjct: 865 PSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQ 923
Query: 731 PCCTIKITHKNQA 743
P I+I HKN+A
Sbjct: 924 PPGYIRIVHKNRA 936
>gi|62000702 diacylglycerol kinase kappa [Homo sapiens]
Length = 1271
Score = 135 bits (339), Expect = 2e-31
Identities = 94/308 (30%), Positives = 133/308 (43%), Gaps = 53/308 (17%)
Query: 270 GRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVK-----T 324
G H W + + +CN C + + + + C CK H C R C T
Sbjct: 326 GMHCWYSSYSHRTQHCNVCRESIPALSRDAIICEVCKVKSHRLCALRASKDCKWNTLSIT 385
Query: 325 YSKAKRSGEV-MQHAWVEGNSSV--KCDRCHKSIKCYQSVTARHCVWCRMTFHRKCE--L 379
+ EV M H WVEGN V +C CH+S YQ + C+WC T H C
Sbjct: 386 DDLLLPADEVNMPHQWVEGNMPVSSQCAVCHESCGSYQRLQDFRCLWCNSTVHDDCRRRF 445
Query: 380 STLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGELVMQYKIIPTPGTH----PL 435
S C R ++ PT++ D G+ G+LV+ + PL
Sbjct: 446 SKECCFRSHRSSVIPPTALS----DPKGD---------GQLVVSSDFWNLDWSSACSCPL 492
Query: 436 LVLVNPKSGGRQG-------------------------ERLNFFRDTPDFRVLACGGDGT 470
L+ +N KSG QG L+ F++ FR+L CGGDG+
Sbjct: 493 LIFINSKSGDHQGIVFLRKFKQYLNPSQVFDLLKGGPEAGLSMFKNFARFRILVCGGDGS 552
Query: 471 VGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGY-EGGSLTKILKDIEQSPLVM 529
V W+L ID + +AV+PLGTGNDLAR L WG + + S IL +EQ+ + +
Sbjct: 553 VSWVLSLIDAFGLHEKCQLAVIPLGTGNDLARVLGWGAFWNKSKSPLDILNRVEQASVRI 612
Query: 530 LDRWHLEV 537
LDRW + +
Sbjct: 613 LDRWSVMI 620
Score = 132 bits (332), Expect = 1e-30
Identities = 75/196 (38%), Positives = 108/196 (55%), Gaps = 21/196 (10%)
Query: 553 IMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIE 612
+MNNYF IG+DA I+ F+ R++HP ++NSR+KNK+WY GT E + +KL + +
Sbjct: 857 VMNNYFGIGLDAKISLDFNTRRDEHPGQYNSRLKNKMWYGLLGTKELLQRSYRKLEERVH 916
Query: 613 LECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCV 672
LECDG + L N L+GI +LNI S GG N WG N ++
Sbjct: 917 LECDGETISLPN--LQGIVVLNITSYAGGINFWGSNTAT----------------TEYEA 958
Query: 673 QDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQC--ASVTIRTNKLLPMQVDGEPWMQ 730
+ D LEVV + G+++M + R+AQC +TI + +P+QVDGE W+Q
Sbjct: 959 PAIDDGKLEVVAIFGSVQMAMSRI-INLHHHRIAQCHEVMITIDGEEGIPVQVDGEAWIQ 1017
Query: 731 PCCTIKITHKNQAPMM 746
IKI +KN A M+
Sbjct: 1018 RPGLIKIRYKNAAQML 1033
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 61.2 bits (147), Expect = 3e-09
Identities = 43/140 (30%), Positives = 63/140 (45%), Gaps = 19/140 (13%)
Query: 272 HAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERC---VSRNIPGCVK--TYS 326
H +T + FK+PT+C+ C + G+ KQGL C C + VH RC V+ PG K
Sbjct: 36 HKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTD 95
Query: 327 KAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQSV-TARHCVWCRMTFHRKC--ELSTLC 383
+ + H++ +S CD C + Y V C C M HR+C + +LC
Sbjct: 96 DPRNKHKFRLHSY---SSPTFCDHCGSLL--YGLVHQGMKCSCCEMNVHRRCVRSVPSLC 150
Query: 384 D------GGELRDHILLPTS 397
G L+ I PT+
Sbjct: 151 GVDHTERRGRLQLEIRAPTA 170
Score = 47.0 bits (110), Expect = 7e-05
Identities = 18/49 (36%), Positives = 31/49 (63%), Gaps = 1/49 (2%)
Query: 271 RHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIP 319
+H + + + PT+C+ C +L G+ QG+ C+ C+ VH RCV R++P
Sbjct: 100 KHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCV-RSVP 147
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 58.5 bits (140), Expect = 2e-08
Identities = 38/130 (29%), Positives = 57/130 (43%), Gaps = 26/130 (20%)
Query: 272 HAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKAKRS 331
H +T F +PT+C+ CH + G+ KQG C C +H++C+ + I C A S
Sbjct: 160 HEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCT---GSAINS 216
Query: 332 GEVMQHAWVEGNSSVKCDRCHK-SIKCYQSVT-ARHC---VW-----------CRMTFHR 375
E M H K D H+ + Y+S T HC +W C M H
Sbjct: 217 RETMFH-----KERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHH 271
Query: 376 KCE--LSTLC 383
+C+ ++ LC
Sbjct: 272 RCQTKVANLC 281
Score = 47.0 bits (110), Expect = 7e-05
Identities = 19/50 (38%), Positives = 29/50 (58%)
Query: 267 KGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSR 316
K D H + + ++K PT+C C +L G+ +QGL C C VH RC ++
Sbjct: 227 KIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTK 276
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 56.6 bits (135), Expect = 8e-08
Identities = 44/144 (30%), Positives = 65/144 (45%), Gaps = 29/144 (20%)
Query: 272 HAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERC---VSRNIPGCVK-TYSK 327
H +T + FK+PT+C+ C + G KQG C C + VH+RC V+ + PG K S
Sbjct: 37 HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASD 96
Query: 328 AKRSGEVMQ-HAWVEGNSSVKCDRC--------HKSIKCYQSVTARHCVWCRMTFHRKCE 378
RS + H + +S CD C H+ +KC C M H++C
Sbjct: 97 DPRSKHKFKIHTY---SSPTFCDHCGSLLYGLIHQGMKCDT---------CMMNVHKRCV 144
Query: 379 LS--TLC--DGGELRDHILLPTSI 398
++ +LC D E R I + I
Sbjct: 145 MNVPSLCGTDHTERRGRIYIQAHI 168
Score = 47.4 bits (111), Expect = 5e-05
Identities = 25/82 (30%), Positives = 40/82 (48%), Gaps = 5/82 (6%)
Query: 263 DSGSKGD---GRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIP 319
D G D +H + + + PT+C+ C +L G+ QG+ C C VH+RCV N+P
Sbjct: 90 DKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCV-MNVP 148
Query: 320 GCVKTYSKAKRSGEVMQHAWVE 341
T +R G + A ++
Sbjct: 149 SLCGT-DHTERRGRIYIQAHID 169
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 56.6 bits (135), Expect = 8e-08
Identities = 44/144 (30%), Positives = 65/144 (45%), Gaps = 29/144 (20%)
Query: 272 HAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERC---VSRNIPGCVK-TYSK 327
H +T + FK+PT+C+ C + G KQG C C + VH+RC V+ + PG K S
Sbjct: 37 HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASD 96
Query: 328 AKRSGEVMQ-HAWVEGNSSVKCDRC--------HKSIKCYQSVTARHCVWCRMTFHRKCE 378
RS + H + +S CD C H+ +KC C M H++C
Sbjct: 97 DPRSKHKFKIHTY---SSPTFCDHCGSLLYGLIHQGMKCDT---------CMMNVHKRCV 144
Query: 379 LS--TLC--DGGELRDHILLPTSI 398
++ +LC D E R I + I
Sbjct: 145 MNVPSLCGTDHTERRGRIYIQAHI 168
Score = 47.4 bits (111), Expect = 5e-05
Identities = 25/82 (30%), Positives = 40/82 (48%), Gaps = 5/82 (6%)
Query: 263 DSGSKGD---GRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIP 319
D G D +H + + + PT+C+ C +L G+ QG+ C C VH+RCV N+P
Sbjct: 90 DKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCV-MNVP 148
Query: 320 GCVKTYSKAKRSGEVMQHAWVE 341
T +R G + A ++
Sbjct: 149 SLCGT-DHTERRGRIYIQAHID 169
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 53.1 bits (126), Expect = 9e-07
Identities = 20/50 (40%), Positives = 31/50 (62%)
Query: 272 HAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGC 321
H +++ ++K PT+C+ C +L G+ +QGL C CK VH RC + P C
Sbjct: 246 HKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNC 295
Score = 47.0 bits (110), Expect = 7e-05
Identities = 35/118 (29%), Positives = 50/118 (42%), Gaps = 12/118 (10%)
Query: 272 HAWTMKHFKKPTYCNFCHIMLMGV-RKQGLCCTYCKYTVHERCVSRNIPGCV------KT 324
H + + ++PTYC+ C + GV KQG C C VH+RC + C K
Sbjct: 172 HKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNINKV 231
Query: 325 YSK--AKRSGEVMQHAWVEGNSSVK--CDRCHKSIKCYQSVTARHCVWCRMTFHRKCE 378
SK +R G + H + N V CD C S+ C C+M H +C+
Sbjct: 232 DSKIAEQRFGINIPHKFSIHNYKVPTFCDHC-GSLLWGIMRQGLQCKICKMNVHIRCQ 288
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 53.1 bits (126), Expect = 9e-07
Identities = 34/123 (27%), Positives = 53/123 (43%), Gaps = 12/123 (9%)
Query: 272 HAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKAK-- 329
H + F +PT+C+ C + G+ KQG C C +H++C+ + I C T + ++
Sbjct: 159 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDT 218
Query: 330 -----RSGEVMQHAWVEGN--SSVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKC--ELS 380
R M H + N S CD C S+ C C M H KC +++
Sbjct: 219 IFQKERFNIDMPHRFKVHNYMSPTFCDHC-GSLLWGLVKQGLKCEDCGMNVHHKCREKVA 277
Query: 381 TLC 383
LC
Sbjct: 278 NLC 280
Score = 43.1 bits (100), Expect = 0.001
Identities = 17/45 (37%), Positives = 26/45 (57%)
Query: 269 DGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERC 313
D H + + ++ PT+C+ C +L G+ KQGL C C VH +C
Sbjct: 228 DMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKC 272
>gi|31377782 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 53.1 bits (126), Expect = 9e-07
Identities = 34/123 (27%), Positives = 53/123 (43%), Gaps = 12/123 (9%)
Query: 272 HAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKAK-- 329
H + F +PT+C+ C + G+ KQG C C +H++C+ + I C T + ++
Sbjct: 159 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDT 218
Query: 330 -----RSGEVMQHAWVEGN--SSVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKC--ELS 380
R M H + N S CD C S+ C C M H KC +++
Sbjct: 219 IFQKERFNIDMPHRFKVHNYMSPTFCDHC-GSLLWGLVKQGLKCEDCGMNVHHKCREKVA 277
Query: 381 TLC 383
LC
Sbjct: 278 NLC 280
Score = 43.1 bits (100), Expect = 0.001
Identities = 17/45 (37%), Positives = 26/45 (57%)
Query: 269 DGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERC 313
D H + + ++ PT+C+ C +L G+ KQGL C C VH +C
Sbjct: 228 DMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKC 272
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 53.1 bits (126), Expect = 9e-07
Identities = 40/144 (27%), Positives = 61/144 (42%), Gaps = 29/144 (20%)
Query: 272 HAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERC---VSRNIPGCVK--TYS 326
H + + FK+PT+C+ C + G KQG C C + VH+RC V+ + PG K
Sbjct: 37 HKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTD 96
Query: 327 KAKRSGEVMQHAWVEGNSSVKCDRC--------HKSIKCYQSVTARHCVWCRMTFHRKCE 378
+ + H + S CD C H+ +KC C M H++C
Sbjct: 97 DPRSKHKFKIHTY---GSPTFCDHCGSLLYGLIHQGMKCDT---------CDMNVHKQCV 144
Query: 379 LS--TLC--DGGELRDHILLPTSI 398
++ +LC D E R I L +
Sbjct: 145 INVPSLCGMDHTEKRGRIYLKAEV 168
Score = 42.4 bits (98), Expect = 0.002
Identities = 21/58 (36%), Positives = 32/58 (55%), Gaps = 5/58 (8%)
Query: 262 DDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIP 319
DD SK H + + + PT+C+ C +L G+ QG+ C C VH++CV N+P
Sbjct: 96 DDPRSK----HKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVI-NVP 148
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 52.0 bits (123), Expect = 2e-06
Identities = 20/50 (40%), Positives = 30/50 (60%)
Query: 272 HAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGC 321
H + + ++K PT+C+ C +L G+ +QGL C CK VH RC + P C
Sbjct: 243 HKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNC 292
Score = 50.1 bits (118), Expect = 8e-06
Identities = 35/117 (29%), Positives = 49/117 (41%), Gaps = 11/117 (9%)
Query: 272 HAWTMKHFKKPTYCNFCHIMLMGV-RKQGLCCTYCKYTVHERCVSRNIPGCVKTYSK--- 327
H + + ++PTYC+ C + GV KQG C C VH+RC I C +
Sbjct: 170 HKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETP 229
Query: 328 ----AKRSGEVMQHAWVEGNSSVK--CDRCHKSIKCYQSVTARHCVWCRMTFHRKCE 378
++R M H + N V CD C S+ C C+M HR+CE
Sbjct: 230 DQVGSQRFSVNMPHKFGIHNYKVPTFCDHC-GSLLWGLLRQGLQCKVCKMNVHRRCE 285
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,342,002
Number of Sequences: 37866
Number of extensions: 1581304
Number of successful extensions: 5378
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 130
Number of HSP's successfully gapped in prelim test: 70
Number of HSP's that attempted gapping in prelim test: 4959
Number of HSP's gapped (non-prelim): 303
length of query: 766
length of database: 18,247,518
effective HSP length: 110
effective length of query: 656
effective length of database: 14,082,258
effective search space: 9237961248
effective search space used: 9237961248
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.