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Search of human proteins with 38027923
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38027923 COP9 signalosome subunit 5 [Homo sapiens]
(334 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38027923 COP9 signalosome subunit 5 [Homo sapiens] 676 0.0
gi|5031981 proteasome 26S subunit, non-ATPase 14 [Homo sapiens] 139 4e-33
gi|64762484 BRCA1/BRCA2-containing complex, subunit 3 isoform 2 ... 49 5e-06
gi|13236583 BRCA1/BRCA2-containing complex, subunit 3 isoform 1 ... 49 5e-06
gi|25777615 proteasome 26S non-ATPase subunit 7 [Homo sapiens] 45 9e-05
gi|148227842 Myb-like, SWIRM and MPN domains 1 [Homo sapiens] 39 0.005
gi|33147080 STAM binding protein-like 1 [Homo sapiens] 39 0.005
gi|47132534 STAM binding protein [Homo sapiens] 37 0.025
gi|42519912 STAM binding protein [Homo sapiens] 37 0.025
gi|5453545 STAM binding protein [Homo sapiens] 37 0.025
gi|34147637 COP9 signalosome subunit 6 [Homo sapiens] 37 0.025
gi|4503519 eukaryotic translation initiation factor 3, subunit 5... 34 0.16
gi|229577180 MPN domain containing isoform 2 [Homo sapiens] 33 0.47
gi|71274152 hypothetical protein LOC388939 [Homo sapiens] 32 1.0
gi|31542699 MPN domain containing isoform 1 [Homo sapiens] 30 3.0
gi|27597061 ubiquitin protein ligase E3 component n-recognin 2 [... 29 6.7
>gi|38027923 COP9 signalosome subunit 5 [Homo sapiens]
Length = 334
Score = 676 bits (1745), Expect = 0.0
Identities = 334/334 (100%), Positives = 334/334 (100%)
Query: 1 MAASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISAL 60
MAASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISAL
Sbjct: 1 MAASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISAL 60
Query: 61 ALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAY 120
ALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAY
Sbjct: 61 ALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAY 120
Query: 121 IENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGK 180
IENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGK
Sbjct: 121 IENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGK 180
Query: 181 VNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLEL 240
VNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLEL
Sbjct: 181 VNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLEL 240
Query: 241 LWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKL 300
LWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKL
Sbjct: 241 LWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKL 300
Query: 301 AKATRDSCKTTIEAIHGLMSQVIKDKLFNQINIS 334
AKATRDSCKTTIEAIHGLMSQVIKDKLFNQINIS
Sbjct: 301 AKATRDSCKTTIEAIHGLMSQVIKDKLFNQINIS 334
>gi|5031981 proteasome 26S subunit, non-ATPase 14 [Homo sapiens]
Length = 310
Score = 139 bits (350), Expect = 4e-33
Identities = 86/252 (34%), Positives = 136/252 (53%), Gaps = 20/252 (7%)
Query: 57 ISALALLKMVMHARSGGNLEVMGLMLGK-VDGETMIIMDSFALPVEGTETRVNAQAAAYE 115
IS+LALLKM+ H R+G +EVMGLMLG+ VD T+ ++D FA+P GT V A ++
Sbjct: 33 ISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQ 92
Query: 116 YMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRT 175
A ++ KQ GR E +GWYHSHPG+GCWLSG+D++TQ + E VAVV+DP ++
Sbjct: 93 --AKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQS 150
Query: 176 ISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHC------KQYYALEVSYF 229
+ GKV + AFR P + T L + + + YY++ ++Y
Sbjct: 151 VK-GKVVIDAFRLINANMMVLGHEPRQ-TTSNLGHLNKPSIQALIHGLNRHYYSITINYR 208
Query: 230 KSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGL 289
K+ L++K+L L K W+ L+ + + V ++ E + ++ +
Sbjct: 209 KNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAK---------NYNKAV 259
Query: 290 ETHDRKSEDKLA 301
E D+ + ++LA
Sbjct: 260 EEEDKMTPEQLA 271
>gi|64762484 BRCA1/BRCA2-containing complex, subunit 3 isoform 2
[Homo sapiens]
Length = 291
Score = 49.3 bits (116), Expect = 5e-06
Identities = 37/136 (27%), Positives = 55/136 (40%), Gaps = 27/136 (19%)
Query: 61 ALLKMVMHARSGGNLEVMGLMLG------------------------KVDGETMIIMDSF 96
A L + HA S EVMGL +G KVD ++ + S
Sbjct: 18 AFLVCLNHALSTEKEEVMGLCIGELNDDTRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSV 77
Query: 97 ALPVEGTETRVNAQAAAYEYMAAYIEN---AKQVGRLENAIGWYHSHPGYGCWLSGIDVS 153
+ + + + + + AA E A+ GR +GWYHSHP W S +DV
Sbjct: 78 IILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVR 137
Query: 154 TQMLNQQFQEPFVAVV 169
TQ + Q + FV ++
Sbjct: 138 TQAMYQMMDQGFVGLI 153
>gi|13236583 BRCA1/BRCA2-containing complex, subunit 3 isoform 1
[Homo sapiens]
Length = 316
Score = 49.3 bits (116), Expect = 5e-06
Identities = 37/136 (27%), Positives = 55/136 (40%), Gaps = 27/136 (19%)
Query: 61 ALLKMVMHARSGGNLEVMGLMLG------------------------KVDGETMIIMDSF 96
A L + HA S EVMGL +G KVD ++ + S
Sbjct: 18 AFLVCLNHALSTEKEEVMGLCIGELNDDTRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSV 77
Query: 97 ALPVEGTETRVNAQAAAYEYMAAYIEN---AKQVGRLENAIGWYHSHPGYGCWLSGIDVS 153
+ + + + + + AA E A+ GR +GWYHSHP W S +DV
Sbjct: 78 IILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVR 137
Query: 154 TQMLNQQFQEPFVAVV 169
TQ + Q + FV ++
Sbjct: 138 TQAMYQMMDQGFVGLI 153
>gi|25777615 proteasome 26S non-ATPase subunit 7 [Homo sapiens]
Length = 324
Score = 45.1 bits (105), Expect = 9e-05
Identities = 30/119 (25%), Positives = 56/119 (47%), Gaps = 8/119 (6%)
Query: 57 ISALALLKMVMH----ARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAA 112
+ L LL +V H + G V+G++LG + + + +SFA+P + + +
Sbjct: 11 VHPLVLLSVVDHFNRIGKVGNQKRVVGVLLGSWQKKVLDVSNSFAVPFDEDDKDDSVWFL 70
Query: 113 AYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVID 171
++Y+ K+V E +GWYH+ P L D++ L +++ V V+ID
Sbjct: 71 DHDYLENMYGMFKKVNARERIVGWYHTGPK----LHKNDIAINELMKRYCPNSVLVIID 125
>gi|148227842 Myb-like, SWIRM and MPN domains 1 [Homo sapiens]
Length = 828
Score = 39.3 bits (90), Expect = 0.005
Identities = 35/127 (27%), Positives = 55/127 (43%), Gaps = 20/127 (15%)
Query: 56 KISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVN------A 109
K+++ ALL M +HA EV+GL+ G+ ++ A P T + +
Sbjct: 578 KVASEALLIMDLHAHVS-MAEVIGLLGGRYSEVDKVVEVCAAEPCNSLSTGLQCEMDPVS 636
Query: 110 QAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQF----QEPF 165
Q A E +A R + IGWYHSHP + S D+ TQ Q + F
Sbjct: 637 QTQASETLAV---------RGFSVIGWYHSHPAFDPNPSLRDIDTQAKYQSYFSRGGAKF 687
Query: 166 VAVVIDP 172
+ +++ P
Sbjct: 688 IGMIVSP 694
>gi|33147080 STAM binding protein-like 1 [Homo sapiens]
Length = 436
Score = 39.3 bits (90), Expect = 0.005
Identities = 33/138 (23%), Positives = 59/138 (42%), Gaps = 26/138 (18%)
Query: 75 LEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLEN-- 132
+E G++ GK+ I T V Q+A +Y +EN +++ +++
Sbjct: 291 IETCGILCGKLTHNEFTI----------THVIVPKQSAGPDYCD--MENVEELFNVQDQH 338
Query: 133 ---AIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPT-------RTISAGKVN 182
+GW H+HP +LS +D+ T Q +A+V P R +AG +
Sbjct: 339 DLLTLGWIHTHPTQTAFLSSVDLHTHCSYQLMLPEAIAIVCSPKHKDTGIFRLTNAGMLE 398
Query: 183 LGAFRTYPKGYKPPDEGP 200
+ A + KG+ P + P
Sbjct: 399 VSACK--KKGFHPHTKEP 414
>gi|47132534 STAM binding protein [Homo sapiens]
Length = 424
Score = 37.0 bits (84), Expect = 0.025
Identities = 26/109 (23%), Positives = 49/109 (44%), Gaps = 17/109 (15%)
Query: 69 ARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVG 128
A + +E G++ GK ++ + F + T + Q+A +Y EN +++
Sbjct: 273 ANTARGVETCGILCGK------LMRNEFTI----THVLIPKQSAGSDYCNT--ENEEELF 320
Query: 129 RLEN-----AIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDP 172
+++ +GW H+HP +LS +D+ T Q VA+V P
Sbjct: 321 LIQDQQGLITLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESVAIVCSP 369
>gi|42519912 STAM binding protein [Homo sapiens]
Length = 424
Score = 37.0 bits (84), Expect = 0.025
Identities = 26/109 (23%), Positives = 49/109 (44%), Gaps = 17/109 (15%)
Query: 69 ARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVG 128
A + +E G++ GK ++ + F + T + Q+A +Y EN +++
Sbjct: 273 ANTARGVETCGILCGK------LMRNEFTI----THVLIPKQSAGSDYCNT--ENEEELF 320
Query: 129 RLEN-----AIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDP 172
+++ +GW H+HP +LS +D+ T Q VA+V P
Sbjct: 321 LIQDQQGLITLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESVAIVCSP 369
>gi|5453545 STAM binding protein [Homo sapiens]
Length = 424
Score = 37.0 bits (84), Expect = 0.025
Identities = 26/109 (23%), Positives = 49/109 (44%), Gaps = 17/109 (15%)
Query: 69 ARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVG 128
A + +E G++ GK ++ + F + T + Q+A +Y EN +++
Sbjct: 273 ANTARGVETCGILCGK------LMRNEFTI----THVLIPKQSAGSDYCNT--ENEEELF 320
Query: 129 RLEN-----AIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDP 172
+++ +GW H+HP +LS +D+ T Q VA+V P
Sbjct: 321 LIQDQQGLITLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESVAIVCSP 369
>gi|34147637 COP9 signalosome subunit 6 [Homo sapiens]
Length = 327
Score = 37.0 bits (84), Expect = 0.025
Identities = 21/71 (29%), Positives = 36/71 (50%), Gaps = 3/71 (4%)
Query: 67 MHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQ 126
M ++ G ++V+G ++GK +G + +M+SF L E ++ EY E KQ
Sbjct: 58 MRSQEGRPVQVIGALIGKQEGRNIEVMNSFELLSHTVEEKIIIDK---EYYYTKEEQFKQ 114
Query: 127 VGRLENAIGWY 137
V + +GWY
Sbjct: 115 VFKELEFLGWY 125
>gi|4503519 eukaryotic translation initiation factor 3, subunit 5
epsilon, 47kDa [Homo sapiens]
Length = 357
Score = 34.3 bits (77), Expect = 0.16
Identities = 21/68 (30%), Positives = 34/68 (50%), Gaps = 3/68 (4%)
Query: 70 RSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGR 129
R+ G V+G +LG VD ++ + + F++P +E V A E+ E K+V
Sbjct: 109 RNEGAARVIGTLLGTVDKHSVEVTNCFSVPHNESEDEV---AVDMEFAKNMYELHKKVSP 165
Query: 130 LENAIGWY 137
E +GWY
Sbjct: 166 NELILGWY 173
>gi|229577180 MPN domain containing isoform 2 [Homo sapiens]
Length = 451
Score = 32.7 bits (73), Expect = 0.47
Identities = 32/124 (25%), Positives = 56/124 (45%), Gaps = 17/124 (13%)
Query: 134 IGWYHSHPGYGCWLSGIDVSTQMLNQ-QFQ------EPFVAVVIDPTRTISAG-KVNLGA 185
+GWYHSHP S D+ QM Q + Q +P +A++ P + + G + +
Sbjct: 295 VGWYHSHPHSPALPSLQDIDAQMDYQLRLQGSSNGFQPCLALLCSPYYSGNPGPESKISP 354
Query: 186 FRTYPKGYKPPDEGPSEY---QTIPLNKIEDFGV--HCKQYYALEVSYFKSSLDRKLLEL 240
F P PP++ PS+Y + + ++D + L V ++K S D L+
Sbjct: 355 FWVMP----PPEQRPSDYGIPMDVEMAYVQDSFLTNDILHEMMLLVEFYKGSPDLVRLQE 410
Query: 241 LWNK 244
W++
Sbjct: 411 PWSQ 414
>gi|71274152 hypothetical protein LOC388939 [Homo sapiens]
Length = 1288
Score = 31.6 bits (70), Expect = 1.0
Identities = 22/75 (29%), Positives = 31/75 (41%), Gaps = 1/75 (1%)
Query: 133 AIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKG 192
AI W+HS P G + + + + P V PTRT + + R+ P
Sbjct: 957 AIAWHHSGPPSGQNRTSESSLARPRQSRERSPPVGRKASPTRTHWVPQADKRR-RSLPSS 1015
Query: 193 YKPPDEGPSEYQTIP 207
Y+P PS QT P
Sbjct: 1016 YRPAQPSPSAVQTPP 1030
>gi|31542699 MPN domain containing isoform 1 [Homo sapiens]
Length = 471
Score = 30.0 bits (66), Expect = 3.0
Identities = 22/83 (26%), Positives = 34/83 (40%), Gaps = 9/83 (10%)
Query: 76 EVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYE--YMAAYIENAKQVGRLENA 133
EV+G + G+ D + ++ A P AA E Y + ++ +
Sbjct: 292 EVVGYLGGRWDVNSQMLTVLRAFPCRSRLGDAETAAAIEEEIYQSLFLRGL-------SL 344
Query: 134 IGWYHSHPGYGCWLSGIDVSTQM 156
+GWYHSHP S D+ QM
Sbjct: 345 VGWYHSHPHSPALPSLQDIDAQM 367
>gi|27597061 ubiquitin protein ligase E3 component n-recognin 2 [Homo
sapiens]
Length = 1755
Score = 28.9 bits (63), Expect = 6.7
Identities = 12/51 (23%), Positives = 27/51 (52%)
Query: 270 SEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMS 320
SE +++ G ++ +GL+ H + + ++ SC TI++I ++S
Sbjct: 1298 SESIKEMLTTFGTATYKVGLKVHPNEEDPRVPIMCWGSCAYTIQSIERILS 1348
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.131 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,484,148
Number of Sequences: 37866
Number of extensions: 459303
Number of successful extensions: 1174
Number of sequences better than 10.0: 16
Number of HSP's better than 10.0 without gapping: 12
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 1156
Number of HSP's gapped (non-prelim): 19
length of query: 334
length of database: 18,247,518
effective HSP length: 103
effective length of query: 231
effective length of database: 14,347,320
effective search space: 3314230920
effective search space used: 3314230920
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.