Search of human proteins with 33946278

Search of human proteins with 33946278

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|33946278 cofilin 2 [Homo sapiens]
         (166 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14719392 cofilin 2 [Homo sapiens]                                  330   3e-91
gi|33946278 cofilin 2 [Homo sapiens]                                  330   3e-91
gi|5031635 cofilin 1 (non-muscle) [Homo sapiens]                      273   4e-74
gi|5802966 destrin isoform a [Homo sapiens]                           230   5e-61
gi|58530848 destrin isoform b [Homo sapiens]                          209   7e-55
gi|169165083 PREDICTED: similar to Destrin (actin depolymerizing...   163   7e-41
gi|169165465 PREDICTED: similar to Destrin (actin depolymerizing...   161   2e-40
gi|113415024 PREDICTED: similar to destrin [Homo sapiens]             161   2e-40
gi|239754918 PREDICTED: similar to destrin [Homo sapiens]             134   4e-32
gi|239749458 PREDICTED: similar to destrin [Homo sapiens]             134   4e-32
gi|239743590 PREDICTED: hypothetical protein XP_002342890 [Homo ...   134   4e-32
gi|6005846 twinfilin-like protein [Homo sapiens]                       44   8e-05
gi|40068475 twinfilin 1 [Homo sapiens]                                 43   1e-04
gi|4758442 glia maturation factor, beta [Homo sapiens]                 37   0.008
gi|4758440 glia maturation factor, gamma [Homo sapiens]                30   1.2  
gi|45505178 cancer antigen 1 [Homo sapiens]                            27   6.1  
gi|217330641 IWS1 homolog [Homo sapiens]                               27   6.1  

>gi|14719392 cofilin 2 [Homo sapiens]
          Length = 166

 Score =  330 bits (846), Expect = 3e-91
 Identities = 166/166 (100%), Positives = 166/166 (100%)

Query: 1   MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDI 60
           MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDI
Sbjct: 1   MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDI 60

Query: 61  GDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS 120
           GDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
Sbjct: 61  GDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS 120

Query: 121 KDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL 166
           KDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL
Sbjct: 121 KDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL 166


>gi|33946278 cofilin 2 [Homo sapiens]
          Length = 166

 Score =  330 bits (846), Expect = 3e-91
 Identities = 166/166 (100%), Positives = 166/166 (100%)

Query: 1   MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDI 60
           MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDI
Sbjct: 1   MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDI 60

Query: 61  GDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS 120
           GDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
Sbjct: 61  GDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS 120

Query: 121 KDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL 166
           KDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL
Sbjct: 121 KDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL 166


>gi|5031635 cofilin 1 (non-muscle) [Homo sapiens]
          Length = 166

 Score =  273 bits (699), Expect = 4e-74
 Identities = 134/166 (80%), Positives = 149/166 (89%)

Query: 1   MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDI 60
           MASGV V+D VIKVFNDMKVRKSST EE+KKRKKAVLFCLS+DK+ II+EE K+ILVGD+
Sbjct: 1   MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV 60

Query: 61  GDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS 120
           G TV+DPY +FVK+LP  DCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
Sbjct: 61  GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS 120

Query: 121 KDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL 166
           KDAIKKK TGIKHE Q N  +++KDR TL EKLGG+ V+SLEGKPL
Sbjct: 121 KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL 166


>gi|5802966 destrin isoform a [Homo sapiens]
          Length = 165

 Score =  230 bits (586), Expect = 5e-61
 Identities = 114/166 (68%), Positives = 138/166 (83%), Gaps = 1/166 (0%)

Query: 1   MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDI 60
           MASGV V DEV ++F DMKVRK ST EEIKKRKKAV+FCLS DK+ IIVEE K+ILVGD+
Sbjct: 1   MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDV 60

Query: 61  GDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS 120
           G T+ DP+  FV +LP  DCRYALYDA++ETKES+KE+L+F  WAPE APLKSKMIYASS
Sbjct: 61  GVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASS 120

Query: 121 KDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL 166
           KDAIKKKF GIKHE Q NG +D+ +R+ + EKLGG+++V+ EG P+
Sbjct: 121 KDAIKKKFQGIKHECQANGPEDL-NRACIAEKLGGSLIVAFEGCPV 165


>gi|58530848 destrin isoform b [Homo sapiens]
          Length = 148

 Score =  209 bits (533), Expect = 7e-55
 Identities = 103/149 (69%), Positives = 125/149 (83%), Gaps = 1/149 (0%)

Query: 18  MKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDIGDTVEDPYTSFVKLLPL 77
           MKVRK ST EEIKKRKKAV+FCLS DK+ IIVEE K+ILVGD+G T+ DP+  FV +LP 
Sbjct: 1   MKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDVGVTITDPFKHFVGMLPE 60

Query: 78  NDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKFTGIKHEWQV 137
            DCRYALYDA++ETKES+KE+L+F  WAPE APLKSKMIYASSKDAIKKKF GIKHE Q 
Sbjct: 61  KDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASSKDAIKKKFQGIKHECQA 120

Query: 138 NGLDDIKDRSTLGEKLGGNVVVSLEGKPL 166
           NG +D+ +R+ + EKLGG+++V+ EG P+
Sbjct: 121 NGPEDL-NRACIAEKLGGSLIVAFEGCPV 148


>gi|169165083 PREDICTED: similar to Destrin (actin depolymerizing
           factor) [Homo sapiens]
          Length = 252

 Score =  163 bits (412), Expect = 7e-41
 Identities = 90/162 (55%), Positives = 112/162 (69%), Gaps = 9/162 (5%)

Query: 3   SGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDIGD 62
           SGV V DEV  +F D+KV K ST EEIKKRKK V+FCLS DK+ IIVEE K+I  GDIG 
Sbjct: 96  SGVQVADEVCHIFCDIKVHKCSTSEEIKKRKKTVIFCLSADKKCIIVEEGKEISAGDIGV 155

Query: 63  TVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIF-WAPESAPLKSKMIYASSK 121
           T+  P+  FV +LP  DC YALYDA++ETK+S +   V +F WAPE  PLKSKMI+ S K
Sbjct: 156 TITGPFKHFVGMLPEKDCCYALYDASFETKKSGRVLFVCLFLWAPELPPLKSKMIFTSCK 215

Query: 122 DAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEG 163
           DAIKKKF       Q NG +D+ + + + EKL G ++ + EG
Sbjct: 216 DAIKKKF-------QANGPEDL-NWACIAEKLDGYLIAAFEG 249


>gi|169165465 PREDICTED: similar to Destrin (actin depolymerizing
           factor) [Homo sapiens]
          Length = 252

 Score =  161 bits (408), Expect = 2e-40
 Identities = 89/162 (54%), Positives = 112/162 (69%), Gaps = 9/162 (5%)

Query: 3   SGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDIGD 62
           SGV V DEV  +F D+KV K ST EEIKKRKK V+FCLS DK+ IIVEE K+I  GDIG 
Sbjct: 96  SGVQVADEVCHIFCDIKVHKCSTSEEIKKRKKTVIFCLSADKKCIIVEEGKEISAGDIGV 155

Query: 63  TVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIF-WAPESAPLKSKMIYASSK 121
           ++  P+  FV +LP  DC YALYDA++ETK+S +   V +F WAPE  PLKSKMI+ S K
Sbjct: 156 SITGPFKHFVGMLPEKDCCYALYDASFETKKSGRVLFVCLFLWAPELPPLKSKMIFTSCK 215

Query: 122 DAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEG 163
           DAIKKKF       Q NG +D+ + + + EKL G ++ + EG
Sbjct: 216 DAIKKKF-------QANGPEDL-NWACIAEKLDGYLIAAFEG 249


>gi|113415024 PREDICTED: similar to destrin [Homo sapiens]
          Length = 199

 Score =  161 bits (408), Expect = 2e-40
 Identities = 89/162 (54%), Positives = 112/162 (69%), Gaps = 9/162 (5%)

Query: 3   SGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDIGD 62
           SGV V DEV  +F D+KV K ST EEIKKRKK V+FCLS DK+ IIVEE K+I  GDIG 
Sbjct: 43  SGVQVADEVCHIFCDIKVHKCSTSEEIKKRKKTVIFCLSADKKCIIVEEGKEISAGDIGV 102

Query: 63  TVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIF-WAPESAPLKSKMIYASSK 121
           ++  P+  FV +LP  DC YALYDA++ETK+S +   V +F WAPE  PLKSKMI+ S K
Sbjct: 103 SITGPFKHFVGMLPEKDCCYALYDASFETKKSGRVLFVCLFLWAPELPPLKSKMIFTSCK 162

Query: 122 DAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEG 163
           DAIKKKF       Q NG +D+ + + + EKL G ++ + EG
Sbjct: 163 DAIKKKF-------QANGPEDL-NWACIAEKLDGYLIAAFEG 196


>gi|239754918 PREDICTED: similar to destrin [Homo sapiens]
          Length = 103

 Score =  134 bits (337), Expect = 4e-32
 Identities = 66/101 (65%), Positives = 80/101 (79%)

Query: 1   MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDI 60
           MASGV V DEV ++F DMKVRK ST EEIKKRKKAV+FCL  D++ IIVEE K+ILVGD+
Sbjct: 1   MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLGADEKCIIVEEGKEILVGDV 60

Query: 61  GDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVF 101
           G T+  P+  FV +LP  DCR ALYDA++ETKES  E+L+F
Sbjct: 61  GVTITGPFKHFVGMLPEKDCRCALYDASFETKESSTEELIF 101


>gi|239749458 PREDICTED: similar to destrin [Homo sapiens]
          Length = 103

 Score =  134 bits (337), Expect = 4e-32
 Identities = 66/101 (65%), Positives = 80/101 (79%)

Query: 1   MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDI 60
           MASGV V DEV ++F DMKVRK ST EEIKKRKKAV+FCL  D++ IIVEE K+ILVGD+
Sbjct: 1   MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLGADEKCIIVEEGKEILVGDV 60

Query: 61  GDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVF 101
           G T+  P+  FV +LP  DCR ALYDA++ETKES  E+L+F
Sbjct: 61  GVTITGPFKHFVGMLPEKDCRCALYDASFETKESSTEELIF 101


>gi|239743590 PREDICTED: hypothetical protein XP_002342890 [Homo
           sapiens]
          Length = 103

 Score =  134 bits (337), Expect = 4e-32
 Identities = 66/101 (65%), Positives = 80/101 (79%)

Query: 1   MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDI 60
           MASGV V DEV ++F DMKVRK ST EEIKKRKKAV+FCL  D++ IIVEE K+ILVGD+
Sbjct: 1   MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLGADEKCIIVEEGKEILVGDV 60

Query: 61  GDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVF 101
           G T+  P+  FV +LP  DCR ALYDA++ETKES  E+L+F
Sbjct: 61  GVTITGPFKHFVGMLPEKDCRCALYDASFETKESSTEELIF 101


>gi|6005846 twinfilin-like protein [Homo sapiens]
          Length = 349

 Score = 43.5 bits (101), Expect = 8e-05
 Identities = 28/102 (27%), Positives = 58/102 (56%), Gaps = 8/102 (7%)

Query: 48  IVEEAKQILVG----DIGDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIF 103
           +V E +Q+++G     +G   +D   + + LL      Y LY    +++ ++  + +F+ 
Sbjct: 30  VVIEDEQLVLGASQEPVGRWDQDYDRAVLPLLDAQQPCYLLY--RLDSQNAQGFEWLFLA 87

Query: 104 WAPESAPLKSKMIYASSKDAIKKKFTG--IKHEWQVNGLDDI 143
           W+P+++P++ KM+YA+++  +KK+F G  IK E      DD+
Sbjct: 88  WSPDNSPVRLKMLYAATRATVKKEFGGGHIKDELFGTVKDDL 129


>gi|40068475 twinfilin 1 [Homo sapiens]
          Length = 384

 Score = 42.7 bits (99), Expect = 1e-04
 Identities = 24/84 (28%), Positives = 50/84 (59%), Gaps = 6/84 (7%)

Query: 51  EAKQILVGDIG---DTVEDPYTSFVKLLPLNDCRYALYDA-TYETKESKKEDLVFIFWAP 106
           E +Q+++G      D+ +  Y SFV  LPL + +   Y     +++ ++  + +FI W+P
Sbjct: 67  ENEQLVIGSYSQPSDSWDKDYDSFV--LPLLEDKQPCYILFRLDSQNAQGYEWIFIAWSP 124

Query: 107 ESAPLKSKMIYASSKDAIKKKFTG 130
           + + ++ KM+YA+++  +KK+F G
Sbjct: 125 DHSHVRQKMLYAATRATLKKEFGG 148


>gi|4758442 glia maturation factor, beta [Homo sapiens]
          Length = 142

 Score = 37.0 bits (84), Expect = 0.008
 Identities = 34/137 (24%), Positives = 65/137 (47%), Gaps = 15/137 (10%)

Query: 19  KVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDIGDTVEDPYTSFVKLLPLN 78
           K+RK   ++E      A++  +  DKR ++++E    L G   D ++D        LP  
Sbjct: 17  KLRKFRFRKETNNA--AIIMKIDKDKRLVVLDEE---LEGISPDELKDE-------LPER 64

Query: 79  DCRYALYDATYETKESKKE-DLVFIFWAPESAPLKSKMIYASSKDAIKKKFTGIKHEWQV 137
             R+ +Y   Y+  + +    L FIF +P     + +M+YA SK+ + +    +   +++
Sbjct: 65  QPRFIVYSYKYQHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNKLVQT-AELTKVFEI 123

Query: 138 NGLDDIKDRSTLGEKLG 154
              +D+ +   L EKLG
Sbjct: 124 RNTEDLTE-EWLREKLG 139


>gi|4758440 glia maturation factor, gamma [Homo sapiens]
          Length = 142

 Score = 29.6 bits (65), Expect = 1.2
 Identities = 30/136 (22%), Positives = 61/136 (44%), Gaps = 15/136 (11%)

Query: 19  KVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDIGDTVEDPYTSFVKLLPLN 78
           K+RK   ++E      A++  +  D++ +++EE  Q +  +               LP  
Sbjct: 17  KLRKFRFRKETDNA--AIIMKVDKDRQMVVLEEEFQNISPE----------ELKMELPER 64

Query: 79  DCRYALYDATYETKESKKE-DLVFIFWAPESAPLKSKMIYASSKDAIKKKFTGIKHEWQV 137
             R+ +Y   Y   + +    L FIF +P     + +M+YA SK+ + +    +   +++
Sbjct: 65  QPRFVVYSYKYVHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNRLVQT-AELTKVFEI 123

Query: 138 NGLDDIKDRSTLGEKL 153
              DD+ + + L EKL
Sbjct: 124 RTTDDLTE-AWLQEKL 138


>gi|45505178 cancer antigen 1 [Homo sapiens]
          Length = 641

 Score = 27.3 bits (59), Expect = 6.1
 Identities = 27/144 (18%), Positives = 67/144 (46%), Gaps = 4/144 (2%)

Query: 10  EVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDIGDTVEDPYT 69
           ++I   ND K    + +E +   +K +    +D  ++++  + K+I    +   +++ Y 
Sbjct: 234 KIILEKNDTKKTLQNLEEVLANTQKHLQESRND--KEMLQLQFKKIKANYV--CLQERYM 289

Query: 70  SFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKFT 129
           + ++    +  +Y   D T   KE + E L  +    E A   +  +    K+A +++F 
Sbjct: 290 TEMQQKNKSVSQYLEMDKTLSKKEEEVERLQQLKKELEKATASALDLLKREKEAQEQEFL 349

Query: 130 GIKHEWQVNGLDDIKDRSTLGEKL 153
            ++ E+Q    +++++R  L  +L
Sbjct: 350 SLQEEFQKLEKENLEERQKLKSRL 373


>gi|217330641 IWS1 homolog [Homo sapiens]
          Length = 819

 Score = 27.3 bits (59), Expect = 6.1
 Identities = 28/116 (24%), Positives = 46/116 (39%), Gaps = 6/116 (5%)

Query: 22  KSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDIGDTVEDPYTSFVKLLPLNDCR 81
           K   +E++ KRK AV   LSD + +      K  +V D  D+  D  +            
Sbjct: 382 KEGEEEKVAKRKAAV---LSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIAS 438

Query: 82  YALYDATYETKESKKEDLVFIFWAPESAPLKSKM---IYASSKDAIKKKFTGIKHE 134
            +  +A  E  + K E+        ES   +  +   I+  S D  +++FTG   E
Sbjct: 439 DSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQE 494


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.133    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 5,628,783
Number of Sequences: 37866
Number of extensions: 220057
Number of successful extensions: 504
Number of sequences better than 10.0: 17
Number of HSP's better than 10.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 486
Number of HSP's gapped (non-prelim): 17
length of query: 166
length of database: 18,247,518
effective HSP length: 95
effective length of query: 71
effective length of database: 14,650,248
effective search space: 1040167608
effective search space used: 1040167608
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 58 (26.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.