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Search of human proteins with 33356148
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33356148 formin-like 1 [Homo sapiens]
(1100 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33356148 formin-like 1 [Homo sapiens] 2193 0.0
gi|52485606 formin-like 2 [Homo sapiens] 1185 0.0
gi|119120874 formin-like 3 isoform 1 [Homo sapiens] 1080 0.0
gi|119120861 formin-like 3 isoform 2 [Homo sapiens] 1065 0.0
gi|40548415 dishevelled associated activator of morphogenesis 2 ... 315 1e-85
gi|21071077 dishevelled-associated activator of morphogenesis 1 ... 308 2e-83
gi|6382071 diaphanous 2 isoform 12C [Homo sapiens] 264 3e-70
gi|5803003 diaphanous 2 isoform 156 [Homo sapiens] 264 3e-70
gi|149999378 inverted formin 2 isoform 2 [Homo sapiens] 256 6e-68
gi|149999380 inverted formin 2 isoform 1 [Homo sapiens] 256 6e-68
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens] 244 4e-64
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens] 244 4e-64
gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens] 238 2e-62
gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens] 216 7e-56
gi|157168329 formin 1 [Homo sapiens] 189 2e-47
gi|160707881 formin 2 [Homo sapiens] 182 1e-45
gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2) int... 161 4e-39
gi|145309324 FH2 domain containing 1 [Homo sapiens] 157 4e-38
gi|58331242 formin homology 2 domain containing 3 [Homo sapiens] 130 9e-30
gi|118572599 formin homology 2 domain containing 1 [Homo sapiens] 119 2e-26
gi|11386183 WAS protein family, member 2 [Homo sapiens] 103 7e-22
gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo sap... 103 1e-21
gi|153792074 proline rich 12 [Homo sapiens] 103 1e-21
gi|56549694 enabled homolog isoform a [Homo sapiens] 99 3e-20
gi|39930375 enabled homolog isoform b [Homo sapiens] 99 3e-20
gi|162329583 cleavage and polyadenylation specific factor 6, 68 ... 97 6e-20
gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens] 94 5e-19
gi|210032580 SET domain containing 1B [Homo sapiens] 90 1e-17
gi|4826998 splicing factor proline/glutamine rich (polypyrimidin... 87 7e-17
gi|150417989 cyclin K isoform 1 [Homo sapiens] 87 9e-17
>gi|33356148 formin-like 1 [Homo sapiens]
Length = 1100
Score = 2193 bits (5683), Expect = 0.0
Identities = 1100/1100 (100%), Positives = 1100/1100 (100%)
Query: 1 MGNAAGSAEQPAGPAAPPPKQPAPPKQPMPAAGELEERFNRALNCMNLPPDKVQLLSQYD 60
MGNAAGSAEQPAGPAAPPPKQPAPPKQPMPAAGELEERFNRALNCMNLPPDKVQLLSQYD
Sbjct: 1 MGNAAGSAEQPAGPAAPPPKQPAPPKQPMPAAGELEERFNRALNCMNLPPDKVQLLSQYD 60
Query: 61 NEKKWELICDQERFQVKNPPAAYIQKLKSYVDTGGVSRKVAADWMSNLGFKRRVQESTQV 120
NEKKWELICDQERFQVKNPPAAYIQKLKSYVDTGGVSRKVAADWMSNLGFKRRVQESTQV
Sbjct: 61 NEKKWELICDQERFQVKNPPAAYIQKLKSYVDTGGVSRKVAADWMSNLGFKRRVQESTQV 120
Query: 121 LRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVTYDMESTDNGASNSEKNKP 180
LRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVTYDMESTDNGASNSEKNKP
Sbjct: 121 LRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVTYDMESTDNGASNSEKNKP 180
Query: 181 LEQSVEDLSKGPPSSVPKSRHLTIKLTPAHSRKALRNSRIVSQKDDVHVCIMCLRAIMNY 240
LEQSVEDLSKGPPSSVPKSRHLTIKLTPAHSRKALRNSRIVSQKDDVHVCIMCLRAIMNY
Sbjct: 181 LEQSVEDLSKGPPSSVPKSRHLTIKLTPAHSRKALRNSRIVSQKDDVHVCIMCLRAIMNY 240
Query: 241 QSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHDIILAAFDNFKEVC 300
QSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHDIILAAFDNFKEVC
Sbjct: 241 QSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHDIILAAFDNFKEVC 300
Query: 301 GEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLGLDLYLE 360
GEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLGLDLYLE
Sbjct: 301 GEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLGLDLYLE 360
Query: 361 RLRLTESDKLQVQIQAYLDNIFDVGALLEDTETKNAVLEHMEELQEQVALLTERLRDAEN 420
RLRLTESDKLQVQIQAYLDNIFDVGALLEDTETKNAVLEHMEELQEQVALLTERLRDAEN
Sbjct: 361 RLRLTESDKLQVQIQAYLDNIFDVGALLEDTETKNAVLEHMEELQEQVALLTERLRDAEN 420
Query: 421 ESMAKIAELEKQLSQARKELETLRERFSESTAMGASRRPPEPEKAPPAAPTRPSALELKV 480
ESMAKIAELEKQLSQARKELETLRERFSESTAMGASRRPPEPEKAPPAAPTRPSALELKV
Sbjct: 421 ESMAKIAELEKQLSQARKELETLRERFSESTAMGASRRPPEPEKAPPAAPTRPSALELKV 480
Query: 481 EELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGA 540
EELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGA
Sbjct: 481 EELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGA 540
Query: 541 APPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGP 600
APPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGP
Sbjct: 541 APPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGP 600
Query: 601 VPPPPPPPPPPPGGPPDALGRRDSELGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVF 660
VPPPPPPPPPPPGGPPDALGRRDSELGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVF
Sbjct: 601 VPPPPPPPPPPPGGPPDALGRRDSELGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVF 660
Query: 661 TELNDEKVLQELDMSDFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAI 720
TELNDEKVLQELDMSDFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAI
Sbjct: 661 TELNDEKVLQELDMSDFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAI 720
Query: 721 TLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSE 780
TLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSE
Sbjct: 721 TLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSE 780
Query: 781 EDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEI 840
EDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEI
Sbjct: 781 EDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEI 840
Query: 841 VLAFGNYMNSSKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSD 900
VLAFGNYMNSSKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSD
Sbjct: 841 VLAFGNYMNSSKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSD 900
Query: 901 LHFLDKAGSVSLDSVLADVRSLQRGLELTQREFVRQDDCMVLKEFLRANSPTMDKLLADS 960
LHFLDKAGSVSLDSVLADVRSLQRGLELTQREFVRQDDCMVLKEFLRANSPTMDKLLADS
Sbjct: 901 LHFLDKAGSVSLDSVLADVRSLQRGLELTQREFVRQDDCMVLKEFLRANSPTMDKLLADS 960
Query: 961 KTAQEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQWKKEAAAQEAGADT 1020
KTAQEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQWKKEAAAQEAGADT
Sbjct: 961 KTAQEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQWKKEAAAQEAGADT 1020
Query: 1021 PGKGEPPAPKSPPKARRPQMDLISELKRRQQKEPLIYESDRDGAIEDIITVIKTVPFTAR 1080
PGKGEPPAPKSPPKARRPQMDLISELKRRQQKEPLIYESDRDGAIEDIITVIKTVPFTAR
Sbjct: 1021 PGKGEPPAPKSPPKARRPQMDLISELKRRQQKEPLIYESDRDGAIEDIITVIKTVPFTAR 1080
Query: 1081 TGKRTSRLLCEASLGEEMPL 1100
TGKRTSRLLCEASLGEEMPL
Sbjct: 1081 TGKRTSRLLCEASLGEEMPL 1100
>gi|52485606 formin-like 2 [Homo sapiens]
Length = 1092
Score = 1185 bits (3066), Expect = 0.0
Identities = 642/1102 (58%), Positives = 791/1102 (71%), Gaps = 46/1102 (4%)
Query: 1 MGNAAGSAEQPAGPAAPPPKQPAPPKQPMPAAGELEERFNRALNCMNLPPDKVQLLSQYD 60
MGNA Q A P K PMP GELEERF LN MNLPPDK +LL QYD
Sbjct: 1 MGNAGSMDSQQTDFRA----HNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYD 56
Query: 61 NEKKWELICDQERFQVKNPPAAYIQKLKSYVDTGGVSRKVAADWMSNLGFKRRVQESTQV 120
NEKKWELICDQERFQVKNPP YIQKLK Y+D +K F+RRVQESTQV
Sbjct: 57 NEKKWELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKK----------FRRRVQESTQV 106
Query: 121 LRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVTYDMESTDNGASNS-EKNK 179
LRELE SLRTNHIGWV+EFLNEEN+GLDVL+EYL+FAQ +VT+D ES ++ +S +K+K
Sbjct: 107 LRELEISLRTNHIGWVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTVESSVDKSK 166
Query: 180 PLEQSVEDLSKGP--PSSVPKS-----RHLTIKLTPAHSRKALRNSRIVSQKDDVHVCIM 232
P +S+EDL +G PS V S RH ++ SR+ L+NSR+VS+KDDVHVCIM
Sbjct: 167 PWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDVHVCIM 226
Query: 233 CLRAIMNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHDIILAA 292
CLRAIMNYQ GF++VM+HP VNEIALSLNNKNPRTKALVLELLAAVCLVRGGH+IIL+A
Sbjct: 227 CLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSA 286
Query: 293 FDNFKEVCGEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTH 352
FDNFKEVCGE+ RFEKLME+FRNED+NIDFMVA MQFINIVVHSVE+MNFRV LQYEFT
Sbjct: 287 FDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTK 346
Query: 353 LGLDLYLERLRLTESDKLQVQIQAYLDNIFDVGALLEDTETKNAVLEHMEELQEQVALLT 412
LGLD YL++L+ TESDKLQVQIQAYLDN+FDVGALLED ETKNA LE +EEL+E ++ L+
Sbjct: 347 LGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLS 406
Query: 413 ERLRDAENESMAKIAELEKQLSQARKELETLRERFSESTAMGASRRPPEPEKAPPAAPTR 472
E+L+D ENE+M+KI ELEKQL Q KEL+ +RE + ++ + R EK A R
Sbjct: 407 EKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEE--AIQR 464
Query: 473 PSALELKVEELEEKGLIRILR-GPGDAVSIEILPV-AVATPSGGDAPTPGVPTGSPSPDL 530
S LE K+ ELE++G I+I + G GD I ILPV A T S G G G P +
Sbjct: 465 QSTLEKKIHELEKQGTIKIQKKGDGD---IAILPVVASGTLSMGSEVVAGNSVG---PTM 518
Query: 531 APAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPP 590
A+ G PPPPPPLP E + P PP+P P PPP PP P PPPPP
Sbjct: 519 GAASS---GPLPPPPPPLPPSSDTPETVQNGPV-TPPMPPPPPPPPPPPPP----PPPPP 570
Query: 591 PPPPPGTDGPVPPPPPPPPPPPGGPP-DALGRRDSELGPG---VKAKKPIQTKFRMPLLN 646
PPP PG P PP PP P PP G VK KKPI+TKFRMP+ N
Sbjct: 571 PPPLPGPAAETVPAPPLAPPLPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFN 630
Query: 647 WVALKPSQITGTVFTELNDEKVLQELDMSDFEEQFKTKSQGPSLDLSALKSKAAQKAPSK 706
WVALKP+QI GTVF E++DE++L++L++ +FEE FKTK+QGP++DLS+ K K QK +K
Sbjct: 631 WVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKIPQKGSNK 690
Query: 707 ATLIEANRAKNLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLIT 766
TL+EANRAKNLAITLRK A+ IC+AI +DL+ L +DF+E LMRFLPTE E ++
Sbjct: 691 VTLLEANRAKNLAITLRKAGKTADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLR 750
Query: 767 RFEREQRPMEELSEEDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASM 826
+ERE++P+E LS+EDRFM+ FS+I RL ++MT + F+GNF ++ Q+L PQL+AIIAAS+
Sbjct: 751 LYERERKPLENLSDEDRFMMQFSKIERLMQKMTIMAFIGNFAESIQMLTPQLHAIIAASV 810
Query: 827 SIKSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKV 886
SIKSS KL++ILEI+LA GNYMNSSKRGA YGF+LQSLD LL+ KSTDRKQTLLHY+ V
Sbjct: 811 SIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISNV 870
Query: 887 IAEKYPQLTGFHSDLHFLDKAGSVSLDSVLADVRSLQRGLELTQREFVRQDDCMVLKEFL 946
+ EKY Q++ F+++LH+++KA +VSL++VL DV+ LQRG++LT+RE+ D +LKEF+
Sbjct: 871 VKEKYHQVSLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHNTLLKEFI 930
Query: 947 RANSPTMDKLLADSKTAQEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQ 1006
N + KL D+K AQ+AF+ VV+YFGENPKTT P +FF +F RF+KAYK+AE+E E
Sbjct: 931 LNNEGKLKKLQDDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENEL 990
Query: 1007 WKK-EAAAQEAGADTPGKGEPPAPKSPP-KARRPQMDLISELKRRQQKEPLIYESDRDGA 1064
KK E A E + E PKSP K++R Q +LI+EL+RRQ K+ +DGA
Sbjct: 991 RKKQEQALMEKLLEQEALMEQQDPKSPSHKSKRQQQELIAELRRRQVKDNRHVYEGKDGA 1050
Query: 1065 IEDIITVIKTVPFTARTGKRTS 1086
IEDIIT ++ P+ R S
Sbjct: 1051 IEDIITDLRNQPYRRADAVRRS 1072
>gi|119120874 formin-like 3 isoform 1 [Homo sapiens]
Length = 1027
Score = 1080 bits (2793), Expect = 0.0
Identities = 605/1103 (54%), Positives = 744/1103 (67%), Gaps = 106/1103 (9%)
Query: 1 MGNAAGSAEQPAGPAAPPPKQPAPPKQPMPAAGELEERFNRALNCMNLPPDKVQLLSQYD 60
MGN + P P + P P P K PMP ELEERF L+ MNLPPDK +LL QYD
Sbjct: 1 MGNLESAEGVPGEPPSVPLLLP-PGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYD 59
Query: 61 NEKKWELICDQERFQVKNPPAAYIQKLKSYVDTGGVSRKVAADWMSNLGFKRRVQESTQV 120
NEKKW+LICDQERFQVKNPP YIQKL+S++D +K F+RRVQEST+V
Sbjct: 60 NEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKK----------FRRRVQESTKV 109
Query: 121 LRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVTYDMESTDNGASNS-EKNK 179
LRELE SLRTNHIGWV+EFLN+EN+GLDVL++YL+FAQCSV +D E ++G + +K +
Sbjct: 110 LRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLR 169
Query: 180 PLEQSVEDLSKGPPSSVP-------KSRHLTIKLTPAHSRKALRNSRIVSQKDDVHVCIM 232
+S+EDL S P +R ++ + R+AL+NSR+VSQKDDVHVCI+
Sbjct: 170 SWSRSIEDLQPPSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCIL 229
Query: 233 CLRAIMNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHDIILAA 292
CLRAIMNYQ GF+LVM+HP VNEIALSLNNKNPRTKALVLELLAAVCLVRGGH+IILAA
Sbjct: 230 CLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAA 289
Query: 293 FDNFKEVCGEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTH 352
FDNFKEVC E HRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVE+MNFRV LQYEFT
Sbjct: 290 FDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTK 349
Query: 353 LGLDLYLERLRLTESDKLQVQIQAYLDNIFDVGALLEDTETKNAVLEHMEELQEQVALLT 412
LGL+ +L++ R TES+KLQVQIQAYLDN+FDVG LLED ETKN LE +EEL+E V+ LT
Sbjct: 350 LGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLT 409
Query: 413 ERLRDAENESMAKIAELEKQLSQARKELETLRERFSESTAMGASRRPPEPEKAPPAAPTR 472
E+L D ENE+M ++AELEKQL Q KELE+++E + ++ + R EK A R
Sbjct: 410 EKLLDLENENMMRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEE--AFQR 467
Query: 473 PSALELKV---EELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSP- 528
LE V E ++ + L R+ GP + + G+P PS
Sbjct: 468 RCHLEPNVRGLESVDSEALARV--GPAEL-------------------SEGMP---PSDL 503
Query: 529 DLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPP 588
DL A P P PPPP P LP P PP P + PPAPPLPG P
Sbjct: 504 DLLAPAPPPEEVLPLPPPPAPPLPPP---PPPLPDKC---------PPAPPLPGAAP--- 548
Query: 589 PPPPPPPGTDGPVPPPPPPPPPPPGGPPDALGRRDSELGPGVKA---KKPIQTKFRMPLL 645
L G+ A KKPI+TKFR+P+
Sbjct: 549 ----------------------------------SVVLTVGLSAIRIKKPIKTKFRLPVF 574
Query: 646 NWVALKPSQITGTVFTELNDEKVLQELDMSDFEEQFKTKSQGPSLDLSALKSKAAQKAPS 705
NW ALKP+QI+GTVF+EL+DEK+L++LD+ FEE FKTK+QGP+LDL K+K AQKA S
Sbjct: 575 NWTALKPNQISGTVFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAAS 634
Query: 706 KATLIEANRAKNLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLI 765
K TL+EANRAKNLAITLRK AE IC+AI +DLQ L +DF+E LMRFLPTE E L+
Sbjct: 635 KVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLL 694
Query: 766 TRFEREQRPMEELSEEDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAAS 825
++ERE++P+EEL+ EDRFML FS++ RL +RM + FLGNF D Q+L PQLNAIIAAS
Sbjct: 695 RQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAAS 754
Query: 826 MSIKSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVK 885
S+KSS KL+Q+LEI+LA GNYMNSSKRGA YGF+LQSLD LL+ KSTDRK TLLH++
Sbjct: 755 ASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIAL 814
Query: 886 VIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLADVRSLQRGLELTQREFVRQDDCMVLKEF 945
+ EKYP L F +LHF++KA +VSL++VL DV+ L RG+EL +RE D+ VL+ F
Sbjct: 815 TVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDN-SVLRNF 873
Query: 946 LRANSPTMDKLLADSKTAQEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVE 1005
L N +DKL D+KTA+EA+ +VV YFGE+PKTT P +FF +F RFI++YK+AEQE E
Sbjct: 874 LSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENE 933
Query: 1006 QWKK--EAAAQEAGADTPGKGEPPAPKSPPKARRPQMDLISELKRRQQKEPLIYESDRDG 1063
KK E ++ A K + P K + Q +LI+EL+RRQ KE +DG
Sbjct: 934 ARKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQ--QQELIAELRRRQAKEHRPVYEGKDG 991
Query: 1064 AIEDIITVIKTVPFTARTGKRTS 1086
IEDIIT + P R R++
Sbjct: 992 TIEDIITGLHCQPMVVRHQARSA 1014
>gi|119120861 formin-like 3 isoform 2 [Homo sapiens]
Length = 976
Score = 1065 bits (2754), Expect = 0.0
Identities = 601/1094 (54%), Positives = 730/1094 (66%), Gaps = 139/1094 (12%)
Query: 1 MGNAAGSAEQPAGPAAPPPKQPAPPKQPMPAAGELEERFNRALNCMNLPPDKVQLLSQYD 60
MGN + P P + P P P K PMP ELEERF L+ MNLPPDK +LL QYD
Sbjct: 1 MGNLESAEGVPGEPPSVPLLLP-PGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYD 59
Query: 61 NEKKWELICDQERFQVKNPPAAYIQKLKSYVDTGGVSRKVAADWMSNLGFKRRVQESTQV 120
NEKKW+LICDQERFQVKNPP YIQKL+S++D +K F+RRVQEST+V
Sbjct: 60 NEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKK----------FRRRVQESTKV 109
Query: 121 LRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVTYDMESTDNGASNSEKNKP 180
LRELE SLRTNHIGWV+EFLN+EN+GLDVL++YL+FAQCSV Y
Sbjct: 110 LRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMY----------------- 152
Query: 181 LEQSVEDLSKGPPSSVPKSRHLTIKLTPAHSRKALRNSRIVSQKDDVHVCIMCLRAIMNY 240
S++P R+AL+NSR+VSQKDDVHVCI+CLRAIMNY
Sbjct: 153 -------------STLP-------------GRRALKNSRLVSQKDDVHVCILCLRAIMNY 186
Query: 241 QSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHDIILAAFDNFKEVC 300
Q GF+LVM+HP VNEIALSLNNKNPRTKALVLELLAAVCLVRGGH+IILAAFDNFKEVC
Sbjct: 187 QYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVC 246
Query: 301 GEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLGLDLYLE 360
E HRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVE+MNFRV LQYEFT LGL+ +L+
Sbjct: 247 KELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQ 306
Query: 361 RLRLTESDKLQVQIQAYLDNIFDVGALLEDTETKNAVLEHMEELQEQVALLTERLRDAEN 420
+ R TES+KLQVQIQAYLDN+FDVG LLED ETKN LE +EEL+E V+ LTE+L D EN
Sbjct: 307 KSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLEN 366
Query: 421 ESMAKIAELEKQLSQARKELETLRERFSESTAMGASRRPPEPEKAPPAAPTRPSALELKV 480
E+M ++AELEKQL Q KELE+++E + ++ + R EK A R LE V
Sbjct: 367 ENMMRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEE--AFQRRCHLEPNV 424
Query: 481 ---EELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPA 537
E ++ + L R+ GP + + G P DL A
Sbjct: 425 RGLESVDSEALARV--GPAE-----------------------LSEGMPPSDLDLLA--- 456
Query: 538 PGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGT 597
P PPP LP P PPPAPPLP PPPP
Sbjct: 457 -----PAPPPEEVLPLP-------------------PPPAPPLP----------PPPP-- 480
Query: 598 DGPVPPPPPPPPPPPGGPPDALGRRDSELGPGVKA---KKPIQTKFRMPLLNWVALKPSQ 654
P+P PP PP PG P + L G+ A KKPI+TKFR+P+ NW ALKP+Q
Sbjct: 481 --PLPDKCPPAPPLPGAAPSVV------LTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQ 532
Query: 655 ITGTVFTELNDEKVLQELDMSDFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEANR 714
I+GTVF+EL+DEK+L++LD+ FEE FKTK+QGP+LDL K+K AQKA SK TL+EANR
Sbjct: 533 ISGTVFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANR 592
Query: 715 AKNLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRP 774
AKNLAITLRK AE IC+AI +DLQ L +DF+E LMRFLPTE E L+ ++ERE++P
Sbjct: 593 AKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQP 652
Query: 775 MEELSEEDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKL 834
+EEL+ EDRFML FS++ RL +RM + FLGNF D Q+L PQLNAIIAAS S+KSS KL
Sbjct: 653 LEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKL 712
Query: 835 RQILEIVLAFGNYMNSSKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQL 894
+Q+LEI+LA GNYMNSSKRGA YGF+LQSLD LL+ KSTDRK TLLH++ + EKYP L
Sbjct: 713 KQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDL 772
Query: 895 TGFHSDLHFLDKAGSVSLDSVLADVRSLQRGLELTQREFVRQDDCMVLKEFLRANSPTMD 954
F +LHF++KA +VSL++VL DV+ L RG+EL +RE D+ VL+ FL N +D
Sbjct: 773 ANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDN-SVLRNFLSTNEGKLD 831
Query: 955 KLLADSKTAQEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQWKK--EAA 1012
KL D+KTA+EA+ +VV YFGE+PKTT P +FF +F RFI++YK+AEQE E KK E
Sbjct: 832 KLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVM 891
Query: 1013 AQEAGADTPGKGEPPAPKSPPKARRPQMDLISELKRRQQKEPLIYESDRDGAIEDIITVI 1072
++ A K + P K + Q +LI+EL+RRQ KE +DG IEDIIT +
Sbjct: 892 REKQLAQEAKKLDAKTPSQRNKWQ--QQELIAELRRRQAKEHRPVYEGKDGTIEDIITGL 949
Query: 1073 KTVPFTARTGKRTS 1086
P R R++
Sbjct: 950 HCQPMVVRHQARSA 963
>gi|40548415 dishevelled associated activator of morphogenesis 2 [Homo
sapiens]
Length = 1067
Score = 315 bits (808), Expect = 1e-85
Identities = 254/886 (28%), Positives = 413/886 (46%), Gaps = 140/886 (15%)
Query: 215 LRNSRIVSQKDDVHVCIM-CLRAIMNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVL 273
LR+ + + +H ++ C++A+MN G + V+ P ++ IA SL +N +TK VL
Sbjct: 161 LRSMDHATCESRIHTSLIGCIKALMNNSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVL 220
Query: 274 ELLAAVCLVRGGHDIILAAFDNFKEVCGEQHRFEKLMEY-------FRNEDSNIDFMVAC 326
E+L AVCLV GGH +L A +++ E+ RF+ L+ +R+E ++ A
Sbjct: 221 EILGAVCLVPGGHKKVLQAMLHYQVYAAERTRFQTLLNELDRSLGRYRDE---VNLKTAI 277
Query: 327 MQFINIVVHS---VENMNFRVFLQYEFTHLGLDLYLERLRLTESDKLQVQIQAY------ 377
M FIN V+++ +N+ FR+ L+YEF LG+ +++LR E+ L + +
Sbjct: 278 MSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNE 337
Query: 378 ----LDNIFDVGALLEDTETKN--------------------AVLEH------------- 400
L FD+ + DT++ + +VL H
Sbjct: 338 DDLELARRFDMVHI--DTKSASQMFELIHKKLKYTEAYPCLLSVLHHCLQMPYKRNGGYF 395
Query: 401 -----MEELQEQVALLTER-----LRDAENESMAKIAEL---EKQLSQARKELETLRERF 447
++ + +Q+ L ER L EN ++ I + E ++ Q R + E R+
Sbjct: 396 QQWQLLDRILQQIVLQDERGVDPDLAPLENFNVKNIVNMLINENEVKQWRDQAEKFRKEH 455
Query: 448 SESTAMGASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVA 507
E + R E+ E + + LE++ ++R L D ++ E +
Sbjct: 456 MELVS-----RLERKER------------ECETKTLEKEEMMRTLNKMKDKLARESQELR 498
Query: 508 VATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPP 567
A G + +A +E + G PPPP G P + +
Sbjct: 499 QAR-------------GQVAELVAQLSELSTGPVSSPPPP--GGPLTLSSSMTT------ 537
Query: 568 LPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGG-----PPDALGRR 622
+ PPP PPLP PPPPPPP PPG PP PP PP G P D
Sbjct: 538 ---NDLPPPPPPLPFACCPPPPPPPLPPGG-----PPTPPGAPPCLGMGLPLPQDPYPSS 589
Query: 623 DSELGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTELNDEKVLQELDMSDFEEQFK 682
D L + K+ Q + NWV L ++ GTV+ E++D +V + LD+ DFE+ F
Sbjct: 590 DVPL----RKKRVPQPSHPLKSFNWVKLNEERVPGTVWNEIDDMQVFRILDLEDFEKMFS 645
Query: 683 TKSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAITLRKGNLGAERICQAIEAYDLQ 742
+ S A + + ++I+ RA+N I L K L E I QAI D Q
Sbjct: 646 AYQRHQKELGSTEDIYLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQ 705
Query: 743 A-LGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSEEDRFMLCFSRIPRLPERMTTL 801
L D LE L++F+P E+S I E + +E ++ DRF+ SRI +R+ L
Sbjct: 706 EDLAKDMLEQLLKFIP---EKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQAL 762
Query: 802 TFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRL 861
F F + P++ AI+ AS + S +LRQ+LE++LA GN+MN +RG AYGFR+
Sbjct: 763 FFKKKFQERLAEAKPKVEAILLASRELVRSKRLRQMLEVILAIGNFMNKGQRGGAYGFRV 822
Query: 862 QSLDALLEMKST-DRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLADVR 920
SL+ + + KS+ DR +LLHYL+ ++ + +P + S+L L +A V+L + +V
Sbjct: 823 ASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELQHLPEAAKVNLAELEKEVG 882
Query: 921 SLQRGLELT-----QREFVRQDD---CMVLKEFLRANSPTMDKLLADSKTAQEAFESVVE 972
+L+RGL QR VR+ V+ +F+ +S + +L A++ F +
Sbjct: 883 NLRRGLRAVEVLEYQRRQVREPSDKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALM 942
Query: 973 YFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQWKKEAAAQEAGA 1018
+FGE+ P FF +F F++A+ +A Q++E ++ +E A
Sbjct: 943 HFGEHDSKMQPDEFFGIFDTFLQAFSEARQDLEAMRRRKEEEERRA 988
>gi|21071077 dishevelled-associated activator of morphogenesis 1 [Homo
sapiens]
Length = 1078
Score = 308 bits (788), Expect = 2e-83
Identities = 253/938 (26%), Positives = 431/938 (45%), Gaps = 171/938 (18%)
Query: 231 IMCLRAIMNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHDIIL 290
I C++A+MN G + V+ H +N IA SL+ +N +TK VLE+L AVCLV GGH +L
Sbjct: 182 IGCIKALMNNSQGRAHVLAHSESINVIAQSLSTENIKTKVAVLEILGAVCLVPGGHKKVL 241
Query: 291 AAFDNFKEVCGEQHRFEKLME-------YFRNEDSNIDFMVACMQFINIVVH---SVENM 340
A ++++ E+ RF+ L+ +R+E + A M FIN V+ VE++
Sbjct: 242 QAMLHYQKYASERTRFQTLINDLDKSTGRYRDE---VSLKTAIMSFINAVLSQGAGVESL 298
Query: 341 NFRVFLQYEFTHLGLDLYLERLRLTESDKLQVQIQAY--LDN----IFDVGALLEDTETK 394
+FR+ L+YEF LG+ +++LR E+ L + + L N F L +TK
Sbjct: 299 DFRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTK 358
Query: 395 NA----------------------VLEH------------------MEELQEQVALLTER 414
+A +L H ++ + +Q+ + ++
Sbjct: 359 SATQMFELTRKRLTHSEAYPHFMSILHHCLQMPYKRSGNTVQYWLLLDRIIQQIVIQNDK 418
Query: 415 LRDAEN--------ESMAKIAELEKQLSQARKELETLRERFSESTAMGASRRPPEPEKAP 466
+D ++ +++ ++ E ++ Q +++ E +R+ +E ++ E +
Sbjct: 419 GQDPDSTPLENFNIKNVVRMLVNENEVKQWKEQAEKMRKEHNE-LQQKLEKKERECDAKT 477
Query: 467 PAAPTRPSALELKVEELEEKGL--IRILRGPGDAVS----IEILPVAVATPSGGDAPTPG 520
L E+LE++ ++ + D + + V + P G P+PG
Sbjct: 478 QEKEEMMQTLNKMKEKLEKETTEHKQVKQQVADLTAQLHELSRRAVCASIPGG---PSPG 534
Query: 521 VPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPL 580
P G P++ P PPPPPPLPG PP PPLP
Sbjct: 535 APGGP-----FPSSVPGSLLPPPPPPPLPG--------GMLPPPPPPLP----------- 570
Query: 581 PGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGPPDALGRRDSELGPGVKAKKPIQTKF 640
PG PPPPP PPP G PPPG P +G +K K Q
Sbjct: 571 PGG--PPPPPGPPPLGA----------IMPPPGAP----------MGLALKKKSIPQPTN 608
Query: 641 RMPLLNWVALKPSQITGTVFTELNDEKVLQELDMSDFE---------EQFKTKSQGPSLD 691
+ NW L +++ GTV+TE++D KV + LD+ D E + F S +
Sbjct: 609 ALKSFNWSKLPENKLEGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQDFFVNSNSKQKE 668
Query: 692 LSALKSKAAQKAPSK-ATLIEANRAKNLAITLRKGNLGAERICQAIEAYDLQA-LGLDFL 749
A+ + K K ++I+ RA+N I L + L + I +AI D Q L D L
Sbjct: 669 ADAIDDTLSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDEQEDLPKDML 728
Query: 750 ELLMRFLPTEYERSLITRFEREQRPMEELSEEDRFMLCFSRIPRLPERMTTLTFLGNFPD 809
E L++F+P E+S I E + ++ +++ DRF+ SRI +R+ +L F F +
Sbjct: 729 EQLLKFVP---EKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQRLQSLYFKKKFAE 785
Query: 810 TAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRLQSLDALLE 869
+ P++ AI + S + S L+Q+LE+VLAFGNYMN +RG AYGF++ SL+ + +
Sbjct: 786 RVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQRGNAYGFKISSLNKIAD 845
Query: 870 MKST-DRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLADVRSLQRGLEL 928
KS+ D+ TLLHYL+ ++ KYP + + +L + +A V++ + ++ +L+ GL+
Sbjct: 846 TKSSIDKNITLLHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELDKEISTLRSGLKA 905
Query: 929 TQREFVRQDD---------CMVLKEFLRANS---PTMDKLLADSKTAQEAFESVVEYFGE 976
+ E Q V+ +F+ S ++ LLA++K + F V++FGE
Sbjct: 906 VETELEYQKSQPPQPGDKFVSVVSQFITVASFSFSDVEDLLAEAK---DLFTKAVKHFGE 962
Query: 977 NPKTTSPGLFFSLFSRFIKAYKKAEQEVEQWKKEAAAQEAGADTPGKGEPPAPKSPPKAR 1036
P FF +F +F++A +A+QE E +K+ +E A
Sbjct: 963 EAGKIQPDEFFGIFDQFLQAVSEAKQENENMRKKKEEEERRA------------------ 1004
Query: 1037 RPQMDLISELKRRQQKEPLIYESDRDGAIEDIITVIKT 1074
R + L + +R ++ S+ G +D+++ +++
Sbjct: 1005 RMEAQLKEQRERERKMRKAKENSEESGEFDDLVSALRS 1042
>gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]
Length = 1096
Score = 264 bits (675), Expect = 3e-70
Identities = 240/967 (24%), Positives = 422/967 (43%), Gaps = 135/967 (13%)
Query: 170 NGASNSEKNKPLEQSVEDLSKGPPSSVPKSRHLTIKLTPAHSRKALRNSRIVS-QKDDVH 228
+G S+ + LE L+ P S V H + L K L + + K + +
Sbjct: 172 SGISDEKLLNCLESLRVSLTSNPVSWVNNFGHEGLGLLLDELEKLLDKKQQENIDKKNQY 231
Query: 229 VCIMCLRAIMNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGH-- 286
I CL+A MN + G ++ + +A +++ K P ++++L+A+C+V +
Sbjct: 232 KLIQCLKAFMNNKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIVGEENIL 291
Query: 287 DIILAAFDNFKEVCGEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFL 346
D +L A E + RF ++E N+++ + VACMQFIN +V S ++FR+ L
Sbjct: 292 DKLLGAITTAAER-NNRERFSPIVEGLENQEA-LQLQVACMQFINALVTSPYELDFRIHL 349
Query: 347 QYEFTHLGLDLYLERLRLTESDKLQVQIQAYLDNIFDVGALLEDTETKNAVLEHMEELQE 406
+ EF GL L L+ E+D+L +Q++ + +N D L E + N + M+++ E
Sbjct: 350 RNEFLRSGLKTMLPDLKEKENDELDIQLKVFDENKED--DLTELSHRLNDIRAEMDDMNE 407
Query: 407 QVALLTERLRD--AENESMAKIAE-----------------LEKQLSQA----------- 436
LL L+D AEN ++ + +E+ +SQ
Sbjct: 408 VYHLLYNMLKDTAAENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDF 467
Query: 437 --RKELET------------LRERFSESTAMGASRRPPEPEKAPPAAPTRPSALELKVEE 482
R+ L+ + SE A S++ E A A + K++E
Sbjct: 468 KYRQRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDEEFTARQEAQAELQKRDEKIKE 527
Query: 483 LEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAP 542
LE + I+ LR +S +G P P PAA P PG P
Sbjct: 528 LEAE--IQQLRTQAQVLSSS--------------------SGIPGP---PAAPPLPGVGP 562
Query: 543 PPPPPLPGLPSPQEAPPSAPPQAPPLPG-SPEPPPAPPLPGDLPPPPPPPPPPPGTDGPV 601
PPPPP APPLPG +P PPP PPLPG + PPPPPPP P
Sbjct: 563 PPPPP-----------------APPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPPP 605
Query: 602 PPPPPPPPPPPGGPPDALGRRDSELGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFT 661
PPP PPPPG L G+K KK + + M +NW ++P++++ F
Sbjct: 606 PPPLGGVPPPPG--------ISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTELSENCFW 657
Query: 662 ELNDEKVLQELDM-----SDFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEANRAK 716
E + D+ +F Q K + +L+ K+ +K + +++ A+
Sbjct: 658 LRVKEDKFENPDLFAKLALNFATQIKVQKNAEALE--EKKTGPTKKKVKELRILDPKTAQ 715
Query: 717 NLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPME 776
NL+I L + E I I + L ++ L++ LP E+ ++ + +
Sbjct: 716 NLSIFLGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLP---EQKILNELAELKNEYD 772
Query: 777 ELSEEDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQ 836
+L E ++F + S + L R++++ F F + + P + A+ A +K S+ +
Sbjct: 773 DLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNR 832
Query: 837 ILEIVLAFGNYMNSSKRGA-AYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLT 895
+LE+VL GNYMNS R A + GF++ L + + KS D+K TLLH++ + EKY +
Sbjct: 833 LLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDIL 892
Query: 896 GFHSDLHFLDKAGSVSLDSVLADVRSLQRGLELTQREFVR------QDDCMVLK--EFLR 947
F +L ++ A VS + +++ S+++ + +R+ + Q D V K F +
Sbjct: 893 KFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTK 952
Query: 948 ANSPTMDKLLADSKTAQEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQW 1007
+KL + +E++ EYF + KT S FF + F + +A +E +
Sbjct: 953 TAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKR 1012
Query: 1008 KKEAAAQEAGADTPGKGEPPAPKSPPKARRPQMDLISELKRRQQKEPLIYESDRDGAIED 1067
++ E ++ + + + + K+++Q + E D G +++
Sbjct: 1013 REM--------------EEKTRRAKLAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDN 1058
Query: 1068 IITVIKT 1074
++ +++
Sbjct: 1059 LLEALQS 1065
>gi|5803003 diaphanous 2 isoform 156 [Homo sapiens]
Length = 1101
Score = 264 bits (675), Expect = 3e-70
Identities = 240/967 (24%), Positives = 422/967 (43%), Gaps = 135/967 (13%)
Query: 170 NGASNSEKNKPLEQSVEDLSKGPPSSVPKSRHLTIKLTPAHSRKALRNSRIVS-QKDDVH 228
+G S+ + LE L+ P S V H + L K L + + K + +
Sbjct: 172 SGISDEKLLNCLESLRVSLTSNPVSWVNNFGHEGLGLLLDELEKLLDKKQQENIDKKNQY 231
Query: 229 VCIMCLRAIMNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGH-- 286
I CL+A MN + G ++ + +A +++ K P ++++L+A+C+V +
Sbjct: 232 KLIQCLKAFMNNKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIVGEENIL 291
Query: 287 DIILAAFDNFKEVCGEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFL 346
D +L A E + RF ++E N+++ + VACMQFIN +V S ++FR+ L
Sbjct: 292 DKLLGAITTAAER-NNRERFSPIVEGLENQEA-LQLQVACMQFINALVTSPYELDFRIHL 349
Query: 347 QYEFTHLGLDLYLERLRLTESDKLQVQIQAYLDNIFDVGALLEDTETKNAVLEHMEELQE 406
+ EF GL L L+ E+D+L +Q++ + +N D L E + N + M+++ E
Sbjct: 350 RNEFLRSGLKTMLPDLKEKENDELDIQLKVFDENKED--DLTELSHRLNDIRAEMDDMNE 407
Query: 407 QVALLTERLRD--AENESMAKIAE-----------------LEKQLSQA----------- 436
LL L+D AEN ++ + +E+ +SQ
Sbjct: 408 VYHLLYNMLKDTAAENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDF 467
Query: 437 --RKELET------------LRERFSESTAMGASRRPPEPEKAPPAAPTRPSALELKVEE 482
R+ L+ + SE A S++ E A A + K++E
Sbjct: 468 KYRQRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDEEFTARQEAQAELQKRDEKIKE 527
Query: 483 LEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAP 542
LE + I+ LR +S +G P P PAA P PG P
Sbjct: 528 LEAE--IQQLRTQAQVLSSS--------------------SGIPGP---PAAPPLPGVGP 562
Query: 543 PPPPPLPGLPSPQEAPPSAPPQAPPLPG-SPEPPPAPPLPGDLPPPPPPPPPPPGTDGPV 601
PPPPP APPLPG +P PPP PPLPG + PPPPPPP P
Sbjct: 563 PPPPP-----------------APPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPPP 605
Query: 602 PPPPPPPPPPPGGPPDALGRRDSELGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFT 661
PPP PPPPG L G+K KK + + M +NW ++P++++ F
Sbjct: 606 PPPLGGVPPPPG--------ISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTELSENCFW 657
Query: 662 ELNDEKVLQELDM-----SDFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEANRAK 716
E + D+ +F Q K + +L+ K+ +K + +++ A+
Sbjct: 658 LRVKEDKFENPDLFAKLALNFATQIKVQKNAEALE--EKKTGPTKKKVKELRILDPKTAQ 715
Query: 717 NLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPME 776
NL+I L + E I I + L ++ L++ LP E+ ++ + +
Sbjct: 716 NLSIFLGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLP---EQKILNELAELKNEYD 772
Query: 777 ELSEEDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQ 836
+L E ++F + S + L R++++ F F + + P + A+ A +K S+ +
Sbjct: 773 DLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNR 832
Query: 837 ILEIVLAFGNYMNSSKRGA-AYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLT 895
+LE+VL GNYMNS R A + GF++ L + + KS D+K TLLH++ + EKY +
Sbjct: 833 LLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDIL 892
Query: 896 GFHSDLHFLDKAGSVSLDSVLADVRSLQRGLELTQREFVR------QDDCMVLK--EFLR 947
F +L ++ A VS + +++ S+++ + +R+ + Q D V K F +
Sbjct: 893 KFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTK 952
Query: 948 ANSPTMDKLLADSKTAQEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQW 1007
+KL + +E++ EYF + KT S FF + F + +A +E +
Sbjct: 953 TAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKR 1012
Query: 1008 KKEAAAQEAGADTPGKGEPPAPKSPPKARRPQMDLISELKRRQQKEPLIYESDRDGAIED 1067
++ E ++ + + + + K+++Q + E D G +++
Sbjct: 1013 REM--------------EEKTRRAKLAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDN 1058
Query: 1068 IITVIKT 1074
++ +++
Sbjct: 1059 LLEALQS 1065
>gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]
Length = 1240
Score = 256 bits (655), Expect = 6e-68
Identities = 244/898 (27%), Positives = 387/898 (43%), Gaps = 125/898 (13%)
Query: 230 CIMCLRAIMNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRG-GHDI 288
C+ C+RA+MN + G ++++ V +++ +L+ N K V ELLAA+C+ GH +
Sbjct: 101 CVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVL 160
Query: 289 ILAAFDNFKEVCGEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQY 348
L A D++K VC +Q+RF +M D N+ ++V + IN V+ E++ R L+
Sbjct: 161 TLDALDHYKTVCSQQYRFSIVMNELSGSD-NVPYVVTLLSVINAVILGPEDLRARTQLRN 219
Query: 349 EFTHLGLDLYLERLRLTESDKLQVQIQAYLD-NIFDVGALLE-----DTETKNAV----- 397
EF L L L RLR E L +Q++A+ + D LL D + V
Sbjct: 220 EFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLF 279
Query: 398 ------------------LEHMEELQEQVALLTERLRDAENESMAKIAELEK-QLSQARK 438
L H+E LL E L N ++ ++ ++ L + +
Sbjct: 280 HKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQECTLEEVVE 339
Query: 439 ELETLRERFSESTAMGA----------SRRPPEPEKAPPAAPTRPSALELKVEELEEKGL 488
L +++ R S + A S+R P+ P+ E ++
Sbjct: 340 RLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPS---------VEGQQPAA 390
Query: 489 IRILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAP--AAEPAPGAAPPPPP 546
A S IL V+ A TP P P P L P +AEP P PPPPP
Sbjct: 391 AAACEPVDHAQSESILKVSQPRALEQQASTPPPP---PPPPLLPGSSAEPPP---PPPPP 444
Query: 547 PLPGLPSPQEAPPSAPPQAPPLPG-----SPEPPPAPPLPGDLPPPPPPPPPPPGTDGPV 601
PLP + + +A P+APP PPLPG P PP PPLPG PPPPPP PG P
Sbjct: 445 PLPSVGA--KALPTAPPP-PPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPP 501
Query: 602 PPPP--------PPPPPPP-----GGPPDALGRR-------DSELG----PGVKAKKPIQ 637
PPPP PPPPPPP PP A G D LG P + P
Sbjct: 502 PPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNP-- 559
Query: 638 TKFRMPLLNWVALKPSQIT---GTVFTELND-EKVLQELDMSDFEEQFKTKSQGPSLDLS 693
RM LNW L PS + +++ L+ + E D S E F + P
Sbjct: 560 PTLRMKKLNWQKL-PSNVAREHNSMWASLSSPDAEAVEPDFSSIERLFSFPAAKPK--EP 616
Query: 694 ALKSKAAQKAPSKATLIEANRAKNLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLM 753
+ + A+K P + T ++A ++ NL I L++ E + I A D ++ L+ L+
Sbjct: 617 TMVAPRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLL 676
Query: 754 RFLPTEYERSLITRFEREQRPMEELSEEDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQL 813
+ LP ++E + F E+ +L+ D F L IP R+ + +
Sbjct: 677 KLLPEKHEIENLRAFTEER---AKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDM 733
Query: 814 LMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMN-SSKRGAAYGFRLQSLDALLEMKS 872
+ P+ ++AA S+ +S +L +++L GN++N S G A GF++ +L L E KS
Sbjct: 734 VRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKS 793
Query: 873 TDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLADVRSLQRGLELTQRE 932
+ TLLH++++ + +P L DL +A ++L+ + ++ S + L T+R+
Sbjct: 794 QQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERK 853
Query: 933 FVRQDDCMVLKEFLRANSPTMDKLLADSKTAQEAFESV-------VEYFGENPKTTSPGL 985
+ E + + ++ + E FE++ +Y E+ + S
Sbjct: 854 VSAS-----VAEVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLED 908
Query: 986 FFSLFSRFIKAYKKAEQEVEQWKKEAA---------AQEAGADTPGKGEPPAPKSPPK 1034
FS F + +A +E + K++AA A+E G+ P K P K
Sbjct: 909 TFSTMKAFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPVRKGPGK 966
Score = 35.0 bits (79), Expect = 0.39
Identities = 51/242 (21%), Positives = 95/242 (39%), Gaps = 28/242 (11%)
Query: 367 SDKLQVQIQAY--LDNIFDVGALLEDTETKNAVLEHMEELQEQVALLTER-LRDAENESM 423
+++LQ I A+ LD +F+ + E + + E ++L + T + RD ++
Sbjct: 866 TERLQASISAFRALDELFEA-IEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRAL 924
Query: 424 AKIAELEKQLSQARKELETLRERFSESTAMGASRRPPEPEKAPPAAPTRPSALELKVEEL 483
+ + ++Q ++A + +++ +E A +P + P ++ + ++
Sbjct: 925 KENKDRKEQAAKAERR----KQQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLADI 980
Query: 484 EEKGLIR-ILRGPGD------AVSIE----ILPVAVATPSGGDAPTPGVPTGSPSPDLAP 532
+ +R RG GD A S++ PVA + P+G + P P D
Sbjct: 981 RKGFQLRKTARGRGDTDGGSKAASMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATT 1040
Query: 533 AAEP-----APGAAPPPPPPL----PGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGD 583
A+E P P P L G P P E S A + + +P PL G
Sbjct: 1041 ASESRGWDLVDAVTPGPQPTLEQLEEGGPRPLERRSSWYVDASDVLTTEDPQCPQPLEGA 1100
Query: 584 LP 585
P
Sbjct: 1101 WP 1102
>gi|149999380 inverted formin 2 isoform 1 [Homo sapiens]
Length = 1249
Score = 256 bits (655), Expect = 6e-68
Identities = 244/898 (27%), Positives = 387/898 (43%), Gaps = 125/898 (13%)
Query: 230 CIMCLRAIMNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRG-GHDI 288
C+ C+RA+MN + G ++++ V +++ +L+ N K V ELLAA+C+ GH +
Sbjct: 101 CVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVL 160
Query: 289 ILAAFDNFKEVCGEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQY 348
L A D++K VC +Q+RF +M D N+ ++V + IN V+ E++ R L+
Sbjct: 161 TLDALDHYKTVCSQQYRFSIVMNELSGSD-NVPYVVTLLSVINAVILGPEDLRARTQLRN 219
Query: 349 EFTHLGLDLYLERLRLTESDKLQVQIQAYLD-NIFDVGALLE-----DTETKNAV----- 397
EF L L L RLR E L +Q++A+ + D LL D + V
Sbjct: 220 EFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLF 279
Query: 398 ------------------LEHMEELQEQVALLTERLRDAENESMAKIAELEK-QLSQARK 438
L H+E LL E L N ++ ++ ++ L + +
Sbjct: 280 HKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQECTLEEVVE 339
Query: 439 ELETLRERFSESTAMGA----------SRRPPEPEKAPPAAPTRPSALELKVEELEEKGL 488
L +++ R S + A S+R P+ P+ E ++
Sbjct: 340 RLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPS---------VEGQQPAA 390
Query: 489 IRILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAP--AAEPAPGAAPPPPP 546
A S IL V+ A TP P P P L P +AEP P PPPPP
Sbjct: 391 AAACEPVDHAQSESILKVSQPRALEQQASTPPPP---PPPPLLPGSSAEPPP---PPPPP 444
Query: 547 PLPGLPSPQEAPPSAPPQAPPLPG-----SPEPPPAPPLPGDLPPPPPPPPPPPGTDGPV 601
PLP + + +A P+APP PPLPG P PP PPLPG PPPPPP PG P
Sbjct: 445 PLPSVGA--KALPTAPPP-PPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPP 501
Query: 602 PPPP--------PPPPPPP-----GGPPDALGRR-------DSELG----PGVKAKKPIQ 637
PPPP PPPPPPP PP A G D LG P + P
Sbjct: 502 PPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNP-- 559
Query: 638 TKFRMPLLNWVALKPSQIT---GTVFTELND-EKVLQELDMSDFEEQFKTKSQGPSLDLS 693
RM LNW L PS + +++ L+ + E D S E F + P
Sbjct: 560 PTLRMKKLNWQKL-PSNVAREHNSMWASLSSPDAEAVEPDFSSIERLFSFPAAKPK--EP 616
Query: 694 ALKSKAAQKAPSKATLIEANRAKNLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLM 753
+ + A+K P + T ++A ++ NL I L++ E + I A D ++ L+ L+
Sbjct: 617 TMVAPRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLL 676
Query: 754 RFLPTEYERSLITRFEREQRPMEELSEEDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQL 813
+ LP ++E + F E+ +L+ D F L IP R+ + +
Sbjct: 677 KLLPEKHEIENLRAFTEER---AKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDM 733
Query: 814 LMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMN-SSKRGAAYGFRLQSLDALLEMKS 872
+ P+ ++AA S+ +S +L +++L GN++N S G A GF++ +L L E KS
Sbjct: 734 VRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKS 793
Query: 873 TDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLADVRSLQRGLELTQRE 932
+ TLLH++++ + +P L DL +A ++L+ + ++ S + L T+R+
Sbjct: 794 QQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERK 853
Query: 933 FVRQDDCMVLKEFLRANSPTMDKLLADSKTAQEAFESV-------VEYFGENPKTTSPGL 985
+ E + + ++ + E FE++ +Y E+ + S
Sbjct: 854 VSAS-----VAEVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLED 908
Query: 986 FFSLFSRFIKAYKKAEQEVEQWKKEAA---------AQEAGADTPGKGEPPAPKSPPK 1034
FS F + +A +E + K++AA A+E G+ P K P K
Sbjct: 909 TFSTMKAFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPVRKGPGK 966
Score = 35.0 bits (79), Expect = 0.39
Identities = 51/242 (21%), Positives = 95/242 (39%), Gaps = 28/242 (11%)
Query: 367 SDKLQVQIQAY--LDNIFDVGALLEDTETKNAVLEHMEELQEQVALLTER-LRDAENESM 423
+++LQ I A+ LD +F+ + E + + E ++L + T + RD ++
Sbjct: 866 TERLQASISAFRALDELFEA-IEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRAL 924
Query: 424 AKIAELEKQLSQARKELETLRERFSESTAMGASRRPPEPEKAPPAAPTRPSALELKVEEL 483
+ + ++Q ++A + +++ +E A +P + P ++ + ++
Sbjct: 925 KENKDRKEQAAKAERR----KQQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLADI 980
Query: 484 EEKGLIR-ILRGPGD------AVSIE----ILPVAVATPSGGDAPTPGVPTGSPSPDLAP 532
+ +R RG GD A S++ PVA + P+G + P P D
Sbjct: 981 RKGFQLRKTARGRGDTDGGSKAASMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATT 1040
Query: 533 AAEP-----APGAAPPPPPPL----PGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGD 583
A+E P P P L G P P E S A + + +P PL G
Sbjct: 1041 ASESRGWDLVDAVTPGPQPTLEQLEEGGPRPLERRSSWYVDASDVLTTEDPQCPQPLEGA 1100
Query: 584 LP 585
P
Sbjct: 1101 WP 1102
>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
Length = 1263
Score = 244 bits (622), Expect = 4e-64
Identities = 237/1038 (22%), Positives = 441/1038 (42%), Gaps = 214/1038 (20%)
Query: 228 HVCIMCLRAIMNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHD 287
H I CL+A MN + G ++ + + +++ P +LL+A+C++ D
Sbjct: 206 HEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPED 265
Query: 288 I---ILAAFDNFKEVCGEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRV 344
+ +L A E+ E RF+ L++ ++ + I V C+Q IN ++ E ++FRV
Sbjct: 266 MNERVLEAMTERAEM-DEVERFQPLLDGLKS-GTTIALKVGCLQLINALITPAEELDFRV 323
Query: 345 FLQYEFTHLGLDLYLERLRLTESDKLQVQIQAY----LDNIFDVGALLEDTETKNAVLEH 400
++ E LGL L+ LR E++ ++VQ+ + ++ +D+ L+D +
Sbjct: 324 HIRSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDD------IRME 377
Query: 401 MEELQEQVALLTERLRDAE-----------------------------NESMAKI----- 426
M++ E +L ++D++ E +++I
Sbjct: 378 MDDFNEVFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKN 437
Query: 427 -AELEKQLSQARKELETLRERFSESTAMGASR-RPPEPEKAPPAAPTRPSALELKVEELE 484
A+ + + + E+E L ++ + T + S + E EK + T L+++++++E
Sbjct: 438 GADPDFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKME 497
Query: 485 E--KGLIRILRGPGDAVSIEILPVA-------------------------------VATP 511
+ ++ L+G DA+ E +A +
Sbjct: 498 SDFEQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLS 557
Query: 512 SGGDAPTPGVPTGSPSPDLAP---------AAEPAPGAA---------PPPPPPLP---- 549
+ P VP+ +P P P PAPG + PPPPPPLP
Sbjct: 558 AAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVC 617
Query: 550 -----------------------------------GLPSPQEAP-PSAPPQAPPLPGSPE 573
G+PSP P +A P PPLPGS
Sbjct: 618 ISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSAR 677
Query: 574 -PPPAPPLPGD--LPPPPP--------PPPPPPGTDGPVPPPPPP-------PPPPPG-- 613
PPP PPLPG +PPPPP PPPPPP GP PPPPP PPPPPG
Sbjct: 678 IPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPPGMG 737
Query: 614 ---GPPDALGRRDSELGP-GVKAKKPIQTKFRMPLLNWVALKPSQITGTVF-TELNDEK- 667
PP G + + P G+ KK + + ++ NW L ++ F T++ +++
Sbjct: 738 MPPPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSKLVAEDLSQDCFWTKVKEDRF 797
Query: 668 ----VLQELDMSDFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAITLR 723
+ +L ++ F Q KT + K +K + ++++ A+NL+I L
Sbjct: 798 ENNELFAKLTLT-FSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSIFLG 856
Query: 724 KGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSEEDR 783
+ + I I + L ++ L++ +P + +++ + E ++L+E ++
Sbjct: 857 SFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKDE---YDDLAESEQ 913
Query: 784 FMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLA 843
F + +PRL R+ + F F + + + P++ ++ AA ++ S+ +LEI L
Sbjct: 914 FGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLL 973
Query: 844 FGNYMNSSKRGA-AYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLH 902
GNYMN+ R A A+GF + L L + KSTD+K TLLH+L ++ YP + F +L
Sbjct: 974 VGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELA 1033
Query: 903 FLDKAGSVSLDSVLADVRSLQRGLELTQREF------VRQDDCMVLK--EFLRANSPTMD 954
++KA VS +++ ++ +++ + +R+ + D V K F++ +
Sbjct: 1034 HVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYN 1093
Query: 955 KLLADSKTAQEAFESVVEYFGENPKTTSPGLFF-------SLFSRFIKAYKKAEQEVEQW 1007
KL + ++ + EYF +PK S FF ++F + +K +K + E+
Sbjct: 1094 KLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRETEEKM 1153
Query: 1008 KKEAAAQEAGADTPGKGEPPAPKSPPKARRPQMDLISELKRRQQKEPLIYESDRDGAIED 1067
++ A+E + + + + + ++R+Q + E D G ++
Sbjct: 1154 RRAKLAKE---------------------KAEKERLEKQQKREQLIDMNAEGDETGVMDS 1192
Query: 1068 IITVIKT-VPFTARTGKR 1084
++ +++ F + G R
Sbjct: 1193 LLEALQSGAAFRRKRGPR 1210
>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
Length = 1272
Score = 244 bits (622), Expect = 4e-64
Identities = 237/1038 (22%), Positives = 441/1038 (42%), Gaps = 214/1038 (20%)
Query: 228 HVCIMCLRAIMNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHD 287
H I CL+A MN + G ++ + + +++ P +LL+A+C++ D
Sbjct: 215 HEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPED 274
Query: 288 I---ILAAFDNFKEVCGEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRV 344
+ +L A E+ E RF+ L++ ++ + I V C+Q IN ++ E ++FRV
Sbjct: 275 MNERVLEAMTERAEM-DEVERFQPLLDGLKS-GTTIALKVGCLQLINALITPAEELDFRV 332
Query: 345 FLQYEFTHLGLDLYLERLRLTESDKLQVQIQAY----LDNIFDVGALLEDTETKNAVLEH 400
++ E LGL L+ LR E++ ++VQ+ + ++ +D+ L+D +
Sbjct: 333 HIRSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDD------IRME 386
Query: 401 MEELQEQVALLTERLRDAE-----------------------------NESMAKI----- 426
M++ E +L ++D++ E +++I
Sbjct: 387 MDDFNEVFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKN 446
Query: 427 -AELEKQLSQARKELETLRERFSESTAMGASR-RPPEPEKAPPAAPTRPSALELKVEELE 484
A+ + + + E+E L ++ + T + S + E EK + T L+++++++E
Sbjct: 447 GADPDFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKME 506
Query: 485 E--KGLIRILRGPGDAVSIEILPVA-------------------------------VATP 511
+ ++ L+G DA+ E +A +
Sbjct: 507 SDFEQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLS 566
Query: 512 SGGDAPTPGVPTGSPSPDLAP---------AAEPAPGAA---------PPPPPPLP---- 549
+ P VP+ +P P P PAPG + PPPPPPLP
Sbjct: 567 AAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVC 626
Query: 550 -----------------------------------GLPSPQEAP-PSAPPQAPPLPGSPE 573
G+PSP P +A P PPLPGS
Sbjct: 627 ISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSAR 686
Query: 574 -PPPAPPLPGD--LPPPPP--------PPPPPPGTDGPVPPPPPP-------PPPPPG-- 613
PPP PPLPG +PPPPP PPPPPP GP PPPPP PPPPPG
Sbjct: 687 IPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPPGMG 746
Query: 614 ---GPPDALGRRDSELGP-GVKAKKPIQTKFRMPLLNWVALKPSQITGTVF-TELNDEK- 667
PP G + + P G+ KK + + ++ NW L ++ F T++ +++
Sbjct: 747 MPPPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSKLVAEDLSQDCFWTKVKEDRF 806
Query: 668 ----VLQELDMSDFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAITLR 723
+ +L ++ F Q KT + K +K + ++++ A+NL+I L
Sbjct: 807 ENNELFAKLTLT-FSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSIFLG 865
Query: 724 KGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSEEDR 783
+ + I I + L ++ L++ +P + +++ + E ++L+E ++
Sbjct: 866 SFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKDE---YDDLAESEQ 922
Query: 784 FMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLA 843
F + +PRL R+ + F F + + + P++ ++ AA ++ S+ +LEI L
Sbjct: 923 FGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLL 982
Query: 844 FGNYMNSSKRGA-AYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLH 902
GNYMN+ R A A+GF + L L + KSTD+K TLLH+L ++ YP + F +L
Sbjct: 983 VGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELA 1042
Query: 903 FLDKAGSVSLDSVLADVRSLQRGLELTQREF------VRQDDCMVLK--EFLRANSPTMD 954
++KA VS +++ ++ +++ + +R+ + D V K F++ +
Sbjct: 1043 HVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYN 1102
Query: 955 KLLADSKTAQEAFESVVEYFGENPKTTSPGLFF-------SLFSRFIKAYKKAEQEVEQW 1007
KL + ++ + EYF +PK S FF ++F + +K +K + E+
Sbjct: 1103 KLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRETEEKM 1162
Query: 1008 KKEAAAQEAGADTPGKGEPPAPKSPPKARRPQMDLISELKRRQQKEPLIYESDRDGAIED 1067
++ A+E + + + + + ++R+Q + E D G ++
Sbjct: 1163 RRAKLAKE---------------------KAEKERLEKQQKREQLIDMNAEGDETGVMDS 1201
Query: 1068 IITVIKT-VPFTARTGKR 1084
++ +++ F + G R
Sbjct: 1202 LLEALQSGAAFRRKRGPR 1219
>gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens]
Length = 1193
Score = 238 bits (608), Expect = 2e-62
Identities = 271/1152 (23%), Positives = 475/1152 (41%), Gaps = 235/1152 (20%)
Query: 4 AAGSAEQPAGPAAPPPKQPAPPKQPMPAAGELEERFNRALNCMNLPPDKVQLLSQYDNEK 63
A S++ A P P P + EL E F + + MNL DK L + D
Sbjct: 96 AFASSDCSAAPLEMMENFPKPLSE-----NELLELFEKMMEDMNLNEDKKAPLREKDFSI 150
Query: 64 KWELICDQERFQVKNPPAAYIQKLKSYVDTGGV--SRKVAA-DWMSNLGFKRRVQESTQV 120
K E++ +Q + + TG + SR+++ +++ L +
Sbjct: 151 KKEMV---------------MQYINTASKTGSLKRSRQISPQEFIHELKMGSADERLVTC 195
Query: 121 LRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVTYDMESTDNGASNSEKNKP 180
L L SL +N + WV+ F +E GL +LL+ L K
Sbjct: 196 LESLRVSLTSNPVSWVESFGHE---GLGLLLDIL-----------------------EKL 229
Query: 181 LEQSVEDLSKGPPSSVPKSRHLTIKLTPAHSRKALRNSRIVSQKDDVHVCIMCLRAIMNY 240
+ +++ V K++H I+ CL+A+MN
Sbjct: 230 ISGKIQE------KVVKKNQHKVIQ---------------------------CLKALMNT 256
Query: 241 QSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHDIILAAFDNFKEVC 300
Q G +M+ ++ +A +++ ++P V++LL+AVC+V G + IL
Sbjct: 257 QYGLERIMSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIV--GEESILEEVLEALTSA 314
Query: 301 GEQHRFEK---LMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLGLDL 357
GE+ + ++ ++E R+ +++ VACMQ IN +V S ++++FR+ ++ EF GL
Sbjct: 315 GEEKKIDRFFCIVEGLRH--NSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKE 372
Query: 358 YLERLRLTESDKLQVQ---------------------IQAYLDNIFDVGALLEDT--ETK 394
L L+ ++D L +Q I+A LD +DV ++ T ET+
Sbjct: 373 ILPNLKCIKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETR 432
Query: 395 N-----AVLEHMEEL-------QEQVALLTERL------RDAENESMAKIAELEKQLSQ- 435
++L+H+ + Q+ L+ E + RD + L+ L+Q
Sbjct: 433 AEGYFISILQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQF 492
Query: 436 -----ARKELETLRERFSESTAMGASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIR 490
+ +LE E+ SE E E K+ EL+ + ++
Sbjct: 493 VDICIDQAKLEEFEEKASELYKKFEKEFTDHQE-----TQAELQKKEAKINELQAE--LQ 545
Query: 491 ILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAP--GAAPPPPPPL 548
+ A+ P+ + P P G P P P G PPPPP
Sbjct: 546 AFKSQFGAL-----------PADCNIPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-- 592
Query: 549 PGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPP 608
PP PPLPG P P PPPPP G PP P
Sbjct: 593 -------------PPPPPPLPGMRMP---------FSGPVPPPPPLGFLGGQNSPPLPIL 630
Query: 609 PPPPGGPPDALGRRDSELGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTELNDEKV 668
P G+K KK + + M LNW+ ++P ++T F +E
Sbjct: 631 P------------------FGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENK 672
Query: 669 LQELD-MSDFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAITLRKGNL 727
+ +D + E F + + + + K+ +K + +++ A+NL+I L +
Sbjct: 673 YENVDLLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRV 732
Query: 728 GAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSEEDRFMLC 787
E I I D L ++ L++ LP + + + +++F+ E L E ++F++
Sbjct: 733 PYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSE---YSNLCEPEQFVVV 789
Query: 788 FSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNY 847
S + RL R++ + F F + + P + A+ A IK S ++LE+VL GNY
Sbjct: 790 MSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNY 849
Query: 848 MNSSKRGA-AYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDK 906
MN+ R A +GF L SL L + KS D+K TLLH+LV++ EKYP + F DL LDK
Sbjct: 850 MNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDK 909
Query: 907 AGSVSLDSVLADVRSLQRGLELTQRE---FVRQDD-----CMVLKEFLRANSPTMDKLLA 958
A VS++++ ++R + R L+ ++E F +D + F+ + + L
Sbjct: 910 ASKVSVETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSK 969
Query: 959 DSKTAQEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQWKKEAAAQEAGA 1018
+ ++ ++S++ Y+ + K S F + + F + +A +E + K+EA +E
Sbjct: 970 LHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIK-KREAEEKE--- 1025
Query: 1019 DTPGKGEPPAPKSPPKARRPQMDLI--SELKRRQQKEPLI---YESDRDGAIEDIITVIK 1073
K R +L L+R+Q+K+ L+ E D G +++++ ++
Sbjct: 1026 ---------------KRVRIAKELAERERLERQQKKKRLLEMKTEGDETGVMDNLLEALQ 1070
Query: 1074 TVPFTARTGKRT 1085
+ KRT
Sbjct: 1071 SGAAFRDRRKRT 1082
>gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens]
Length = 849
Score = 216 bits (551), Expect = 7e-56
Identities = 220/905 (24%), Positives = 389/905 (42%), Gaps = 153/905 (16%)
Query: 248 MNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHDIILAAFDNFKEVCGEQHRFE 307
M+ ++ +A +++ ++P V++LL+AVC+V G + IL GE+ + +
Sbjct: 1 MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIV--GEESILEEVLEALTSAGEEKKID 58
Query: 308 K---LMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLGLDLYLERLRL 364
+ ++E R+ +++ VACMQ IN +V S ++++FR+ ++ EF GL L L+
Sbjct: 59 RFFCIVEGLRH--NSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKC 116
Query: 365 TESDKLQVQ---------------------IQAYLDNIFDVGALLEDT--ETKN-----A 396
++D L +Q I+A LD +DV ++ T ET+ +
Sbjct: 117 IKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFIS 176
Query: 397 VLEHMEEL-------QEQVALLTERL------RDAENESMAKIAELEKQLSQ------AR 437
+L+H+ + Q+ L+ E + RD + L+ L+Q +
Sbjct: 177 ILQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQ 236
Query: 438 KELETLRERFSESTAMGASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGD 497
+LE E+ SE E E K+ EL+ + ++ +
Sbjct: 237 AKLEEFEEKASELYKKFEKEFTDHQE-----TQAELQKKEAKINELQAE--LQAFKSQFG 289
Query: 498 AVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAP--GAAPPPPPPLPGLPSPQ 555
A+ P+ + P P G P P P G PPPPP
Sbjct: 290 AL-----------PADCNIPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP--------- 329
Query: 556 EAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGP 615
PP PPLPG P P PPPPP G PP P P
Sbjct: 330 ------PPPPPPLPGMRMP---------FSGPVPPPPPLGFLGGQNSPPLPILP------ 368
Query: 616 PDALGRRDSELGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTELNDEKVLQELD-M 674
G+K KK + + M LNW+ ++P ++T F +E + +D +
Sbjct: 369 ------------FGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLL 416
Query: 675 SDFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAITLRKGNLGAERICQ 734
E F + + + + K+ +K + +++ A+NL+I L + E I
Sbjct: 417 CKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRM 476
Query: 735 AIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSEEDRFMLCFSRIPRL 794
I D L ++ L++ LP + + + +++F+ E L E ++F++ S + RL
Sbjct: 477 MILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSE---YSNLCEPEQFVVVMSNVKRL 533
Query: 795 PERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNSSKRG 854
R++ + F F + + P + A+ A IK S ++LE+VL GNYMN+ R
Sbjct: 534 RPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRN 593
Query: 855 A-AYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLD 913
A +GF L SL L + KS D+K TLLH+LV++ EKYP + F DL LDKA VS++
Sbjct: 594 AQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVE 653
Query: 914 SVLADVRSLQRGLELTQRE---FVRQDD-----CMVLKEFLRANSPTMDKLLADSKTAQE 965
++ ++R + R L+ ++E F +D + F+ + + L + ++
Sbjct: 654 TLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEK 713
Query: 966 AFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQWKKEAAAQEAGADTPGKGE 1025
++S++ Y+ + K S F + + F + +A +E + K+EA +E
Sbjct: 714 LYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIK-KREAEEKE---------- 762
Query: 1026 PPAPKSPPKARRPQMDLI--SELKRRQQKEPLI---YESDRDGAIEDIITVIKTVPFTAR 1080
K R +L L+R+Q+K+ L+ E D G +++++ +++
Sbjct: 763 --------KRVRIAKELAERERLERQQKKKRLLEMKTEGDETGVMDNLLEALQSGAAFRD 814
Query: 1081 TGKRT 1085
KRT
Sbjct: 815 RRKRT 819
>gi|157168329 formin 1 [Homo sapiens]
Length = 1196
Score = 189 bits (479), Expect = 2e-47
Identities = 161/523 (30%), Positives = 238/523 (45%), Gaps = 64/523 (12%)
Query: 534 AEPAPGAAPPPPPPLP-GLPSPQEAPPSAPPQA-PPLPGSPEPPPAPPLPGDLPP----P 587
A P P A+ PPPPPLP GL S APP P A PPLP P PPP PPLP PP P
Sbjct: 644 ALPPPPASIPPPPPLPSGLGSLSPAPPMPPVSAGPPLP--PPPPPPPPLP---PPSSAGP 698
Query: 588 PPPPPPPPGTDGPVPP---PPPPPPPPPG---GPPDALGRRDSELGPGVKAKKPIQTKFR 641
PPPPPPPP + P PP PPP PPPPG PP L K I+
Sbjct: 699 PPPPPPPPLPNSPAPPNPGGPPPAPPPPGLAPPPPPGLFFGLGSSSSQCPRKPAIEPSCP 758
Query: 642 MPLLNWVALKPS----QITGTVFTELNDEKVLQELDMSDFEEQF-KTKSQGPSLDLSALK 696
M L W ++ S T T++ L + + D S+FE F K +Q LS
Sbjct: 759 MKPLYWTRIQISDRSQNATPTLWDSLEEPDI---RDPSEFEYLFSKDTTQQKKKPLSETY 815
Query: 697 SKAAQKAPSKATLIEANRAKNLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFL 756
K K L++ R++ + I + +L + I QAI D + L+ L L
Sbjct: 816 EK-KNKVKKIIKLLDGKRSQTVGILISSLHLEMKDIQQAIFNVDDSVVDLETLAALYENR 874
Query: 757 PTEYERSLITRF--EREQRPMEELSEEDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQLL 814
E E I ++ ++ ++ L + ++F+ ++IP ER + F F + L
Sbjct: 875 AQEDELVKIRKYYETSKEEELKLLDKPEQFLHELAQIPNFAERAQCIIFRSVFSEGITSL 934
Query: 815 MPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNSSK--RGAAYGFRLQSLDALLEMKS 872
++ I AS + ++ IL ++LAFGNYMN RG A G+ L+ L L ++KS
Sbjct: 935 HRKVEIITRASKDLLHVKSVKDILALILAFGNYMNGGNRTRGQADGYSLEILPKLKDVKS 994
Query: 873 TDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDK------AGSVSLDSVLADVRSLQRGL 926
D L+ Y+VK Y Q G + L + A V + ++ D+R L+R L
Sbjct: 995 RDNGINLVDYVVKYYLRYYDQEAGTEKSVFPLPEPQDFFLASQVKFEDLIKDLRKLKRQL 1054
Query: 927 ELTQREFV---RQDDCMVLKEFLRANSPTMDKLLADSK-----------TAQEAFESVVE 972
E ++++ V ++ KE+L+ +++ +K AQ++FE+ V
Sbjct: 1055 EASEKQMVVVCKESP----KEYLQPFKDKLEEFFQKAKKEHKMEESHLENAQKSFETTVR 1110
Query: 973 YFGENPKT----TSPGLFFSLFSRFIKAYKKAEQEVEQWKKEA 1011
YFG PK+ +P F ++ F +K WK+E+
Sbjct: 1111 YFGMKPKSGEKEITPSYVFMVWYEFCSDFKTI------WKRES 1147
>gi|160707881 formin 2 [Homo sapiens]
Length = 1722
Score = 182 bits (463), Expect = 1e-45
Identities = 184/654 (28%), Positives = 261/654 (39%), Gaps = 121/654 (18%)
Query: 459 PPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPT 518
PP P P P P A L G+ PG + P P G P
Sbjct: 1045 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI-----PPPPPLPGAGIPPP 1099
Query: 519 PGVP-TGSPSPDLAPAA-----EPAPGAAPPPPPPLPG--LPSPQEAPPSAPPQAPPLPG 570
P +P G P P P A P PGA PPPPPLPG +P P P P PPLPG
Sbjct: 1100 PPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPG 1159
Query: 571 SPEPPPAPPLPG-DLPPPP-------PPPPPPPGTDGPVPPP------PPPPP------- 609
+ PPP PPLPG +PPPP PPPPP PG P PPP PPPPP
Sbjct: 1160 AGIPPP-PPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIP 1218
Query: 610 -------PPPG---GPPDALGRRDSELGPGV----------------------------- 630
PPPG PP L L P V
Sbjct: 1219 PAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLPSGLFGLGMNQ 1278
Query: 631 ---KAKKPIQTKFRMPLLNWVAL----KPSQITGTVFTELNDEKVLQELDMSDFEEQF-K 682
K+PI+ M L W + K T ++ ++ + + D +FEE F K
Sbjct: 1279 DKGSRKQPIEPCRPMKPLYWTRIQLHSKRDSSTSLIWEKIEEPSI----DCHEFEELFSK 1334
Query: 683 TKSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAITLRKGNLGAERICQAIEAYDLQ 742
T + +S SK KA L+ R++ + I + +L + I A+ D
Sbjct: 1335 TAVKERKKPISDTISKT--KAKQVVKLLSNKRSQAVGILMSSLHLDMKDIQHAVVNLDNS 1392
Query: 743 ALGLDFLELLMRFLPTEYERSLITRFEREQRPME---ELSEEDRFMLCFSRIPRLPERMT 799
+ L+ L+ L E I + R + E L + ++F+ S IP ER+
Sbjct: 1393 VVDLETLQALYENRAQSDELEKIEKHGRSSKDKENAKSLDKPEQFLYELSLIPNFSERVF 1452
Query: 800 TLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMN--SSKRGAAY 857
+ F F ++ + +L + ++K+ + Q+L +VLAFGNYMN + RG A
Sbjct: 1453 CILFQSTFSESICSIRRKLELLQKLCETLKNGPGVMQVLGLVLAFGNYMNGGNKTRGQAD 1512
Query: 858 GFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDL------HFLDKAGSVS 911
GF L L L ++KS+D ++LL Y+V + + G L L +A +
Sbjct: 1513 GFGLDILPKLKDVKSSDNSRSLLSYIVSYYLRNFDEDAGKEQCLFPLPEPQDLFQASQMK 1572
Query: 912 LDSVLADVRSLQRGLELTQREFVRQDDCMVLKEFLRANSPTMDKLLADSKTAQEA----- 966
+ D+R L++ L+ + E + + KE ++ M++ + +K QEA
Sbjct: 1573 FEDFQKDLRKLKKDLKACEVEAGKVYQ-VSSKEHMQPFKENMEQFIIQAKIDQEAEENSL 1631
Query: 967 ------FESVVEYFGENP----KTTSPGLFFSLFSRFIKAYKKAEQEVEQWKKE 1010
F YF P K SP FFS++ F +K + WKKE
Sbjct: 1632 TETHKCFLETTAYFFMKPKLGEKEVSPNAFFSIWHEFSSDFK------DFWKKE 1679
Score = 112 bits (280), Expect = 2e-24
Identities = 78/196 (39%), Positives = 89/196 (45%), Gaps = 29/196 (14%)
Query: 449 ESTAMGASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEI----- 503
+ T M PP P P P P A L + L G+ PG A+
Sbjct: 903 QGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGA 962
Query: 504 -LPVAVATPSGGDAPTPGVP-TGSPSPDLAPAA-----EPAPGAAPPPPPPLPG--LPSP 554
+P+ P G P P +P G P P P A P PGA PPPPPLPG +P P
Sbjct: 963 GIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1022
Query: 555 QEAPPSAPPQAPPLPGSPEPPPAPPLPG-DLPPPPP-------PPPPPPGTDGPVPPP-- 604
P + P PPLPG+ PPP PPLPG +PPPPP PPPP PG P PPP
Sbjct: 1023 PPLPGAGIPPPPPLPGAGIPPP-PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1081
Query: 605 ----PPPPPPPPGGPP 616
PPPPP P G P
Sbjct: 1082 GAGIPPPPPLPGAGIP 1097
Score = 110 bits (274), Expect = 1e-23
Identities = 77/192 (40%), Positives = 88/192 (45%), Gaps = 30/192 (15%)
Query: 448 SESTAMGASRRPPEPEKAPP-AAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPV 506
S S+ G PP P P PT PS + L+ +L P + +P
Sbjct: 866 SSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGT---EMLPPPPPPLPGAGIPP 922
Query: 507 AVATPSGGDAPTPGVP-TGSPSPDLAPAAEPAPGAAPPPPPPLPG--LPSPQEAPPSAPP 563
P G P P +P G P P P PGAA PPPPPLPG +P P P + P
Sbjct: 923 PPPLPGAGILPLPPLPGAGIPPPP------PLPGAAIPPPPPLPGAGIPLPPPLPGAGIP 976
Query: 564 QAPPLPGSPEPPPAPPLPGDLPPPPPP------PPPPPGTDGPVPPPP-------PPPPP 610
PPLPG+ PPP PPLPG PPPPP PPPPP +PPPP PPPPP
Sbjct: 977 PPPPLPGAGIPPP-PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 1035
Query: 611 PPGG---PPDAL 619
PG PP L
Sbjct: 1036 LPGAGIPPPPPL 1047
Score = 109 bits (273), Expect = 1e-23
Identities = 76/185 (41%), Positives = 83/185 (44%), Gaps = 30/185 (16%)
Query: 459 PPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPT 518
PP P A P P P A L G+ PG + P P G P
Sbjct: 946 PPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGI-----PPPPPLPGAGIPPP 1000
Query: 519 PGVP-TGSPSPDLAPAA-----EPAPGAAPPPPPPLPG--LPSPQEAPPSAPPQAPPLPG 570
P +P G P P P A P PGA PPPPPLPG +P P P + P PPLPG
Sbjct: 1001 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1060
Query: 571 SPEPPPAPPLPGDLPPPPPP------PPPPPGTDGPVPPPP-------PPPPPPPGG--- 614
+ PPP PPLPG PPPPP PPPPP +PPPP PPPPP PG
Sbjct: 1061 AGIPPP-PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIP 1119
Query: 615 PPDAL 619
PP L
Sbjct: 1120 PPPPL 1124
Score = 109 bits (273), Expect = 1e-23
Identities = 76/187 (40%), Positives = 83/187 (44%), Gaps = 30/187 (16%)
Query: 459 PPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPT 518
PP P P P P A L G+ PG + P P G P
Sbjct: 968 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI-----PPPPPLPGAGIPPP 1022
Query: 519 PGVP-TGSPSPDLAPAA-----EPAPGAAPPPPPPLPG--LPSPQEAPPSAPPQAPPLPG 570
P +P G P P P A P PGA PPPPPLPG +P P P + P PPLPG
Sbjct: 1023 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1082
Query: 571 SPEPPPAPPLPGDLPPPPPP------PPPPPGTDGPVPPPP-------PPPPPPPGG--- 614
+ PPP PPLPG PPPPP PPPPP +PPPP PPPPP PG
Sbjct: 1083 AGIPPP-PPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1141
Query: 615 PPDALGR 621
PP L R
Sbjct: 1142 PPPPLPR 1148
Score = 108 bits (271), Expect = 2e-23
Identities = 72/176 (40%), Positives = 79/176 (44%), Gaps = 27/176 (15%)
Query: 459 PPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPT 518
PP P P P P A L G+ PG + P P G P
Sbjct: 935 PPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGI-----PPPPPLPGAGIPPP 989
Query: 519 PGVP-TGSPSPDLAPAA-----EPAPGAAPPPPPPLPG--LPSPQEAPPSAPPQAPPLPG 570
P +P G P P P A P PGA PPPPPLPG +P P P + P PPLPG
Sbjct: 990 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1049
Query: 571 SPEPPPAPPLPGDLPPPPPP------PPPPPGTDGPVPPPP-------PPPPPPPG 613
+ PPP PPLPG PPPPP PPPPP +PPPP PPPPP PG
Sbjct: 1050 AGIPPP-PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1104
Score = 107 bits (268), Expect = 5e-23
Identities = 72/176 (40%), Positives = 79/176 (44%), Gaps = 27/176 (15%)
Query: 459 PPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPT 518
PP P P P P A L G+ PG + P P G P
Sbjct: 1012 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI-----PPPPPLPGAGIPPP 1066
Query: 519 PGVP-TGSPSPDLAPAA-----EPAPGAAPPPPPPLPG--LPSPQEAPPSAPPQAPPLPG 570
P +P G P P P A P PGA PPPPPLPG +P P P + P PPLPG
Sbjct: 1067 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPG 1126
Query: 571 SPEPPPAPPLPGDLPPPPPP------PPPPPGTDGPVPPPP-------PPPPPPPG 613
+ PPP PPLPG PPPPP PPPPP +PPPP PPPPP PG
Sbjct: 1127 AGIPPP-PPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1181
Score = 105 bits (263), Expect = 2e-22
Identities = 75/185 (40%), Positives = 81/185 (43%), Gaps = 30/185 (16%)
Query: 459 PPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPT 518
PP P P P P A L G+ PG + P P G P
Sbjct: 1001 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI-----PPPPPLPGAGIPPP 1055
Query: 519 PGVP-TGSPSPDLAPAA-----EPAPGAAPPPPPPLPG--LPSPQEAPPSAPPQAPPLPG 570
P +P G P P P A P PGA PPPPPLPG +P P P P PPLPG
Sbjct: 1056 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPG 1115
Query: 571 SPEPPPAPPLPGDLPPPPPP------PPPPPGTDGPVPPPP-------PPPPPPPGG--- 614
+ PPP PPLPG PPPPP PPPPP +PPPP PPPPP PG
Sbjct: 1116 AGIPPP-PPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIP 1174
Query: 615 PPDAL 619
PP L
Sbjct: 1175 PPPPL 1179
Score = 94.0 bits (232), Expect = 7e-19
Identities = 56/132 (42%), Positives = 61/132 (46%), Gaps = 41/132 (31%)
Query: 526 PSPDLAPAAE-----PAPGAAPPPPPPLPGL------------PSPQEAPPSAPPQAPPL 568
PSP P E P G PPPPPPLPG+ P P + PP PPL
Sbjct: 856 PSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPL 915
Query: 569 PGSPEPPPAP----------PLPG-DLPPPPP-------PPPPPPGTDGPVPPP------ 604
PG+ PPP P PLPG +PPPPP PPPP PG P+PPP
Sbjct: 916 PGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGI 975
Query: 605 PPPPPPPPGGPP 616
PPPPP P G P
Sbjct: 976 PPPPPLPGAGIP 987
Score = 92.8 bits (229), Expect = 2e-18
Identities = 70/202 (34%), Positives = 85/202 (42%), Gaps = 36/202 (17%)
Query: 448 SESTAMGASRRPPEP-------EKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVS 500
S S+ PP P + P + P P ++ + + E + + + S
Sbjct: 800 SHQPTQSISQPPPPPSLLWSAGQGQPGSQP--PHSISTEFQTSHEHSVSSAFKNSCNIPS 857
Query: 501 IEILPVAVAT---PSGGDAPTPGVPT-GSPSPDLAPAAEPAPGAA------PPPPPPLPG 550
LP ++ P G P P P G P L A P P PPPPPPLPG
Sbjct: 858 PPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPG 917
Query: 551 --LPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPP--------PPPPPGTDGP 600
+P P P + PPLPG+ PPP PPLPG PPPPP PPP PG P
Sbjct: 918 AGIPPPPPLPGAGILPLPPLPGAGIPPP-PPLPGAAIPPPPPLPGAGIPLPPPLPGAGIP 976
Query: 601 VPPP------PPPPPPPPGGPP 616
PPP PPPPP P G P
Sbjct: 977 PPPPLPGAGIPPPPPLPGAGIP 998
Score = 77.8 bits (190), Expect = 5e-14
Identities = 86/325 (26%), Positives = 119/325 (36%), Gaps = 99/325 (30%)
Query: 390 DTETKNAVLEHMEELQEQV------------ALLTERLRDAENESMAKIAELEKQLSQAR 437
+TE+++AV E ++ + V A + ++L + KIAELE+Q
Sbjct: 642 ETESQSAVSETPQKRSDAVQKEVVDMKSEGQATVIQQLEQTIEDLRTKIAELERQYPALD 701
Query: 438 KELETLRERFSES-TAMG-ASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRI---- 491
E+ + + TA G E+ A ++ EE G++ +
Sbjct: 702 TEVASGHQGLENGVTASGDVCLEALRLEEKEVRHHRILEAKSIQTSPTEEGGVLTLPPVD 761
Query: 492 -LRG-----PG----------DAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLA-PAA 534
L G PG +S+ + P ++ PT + P P L A
Sbjct: 762 GLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPPPPPSLLWSAG 821
Query: 535 EPAPGAAPP------------------------------------------------PPP 546
+ PG+ PP PPP
Sbjct: 822 QGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPP 881
Query: 547 PLPGLPSPQEAPPSAPPQAPPLPGSPE-PPPAPPLPG-DLPPPPP-------PPPPPPGT 597
PLPG+ P P +A PQ PPL G+ PPP PPLPG +PPPPP P PP PG
Sbjct: 882 PLPGMTVP-TLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGA 940
Query: 598 DGPVPPP------PPPPPPPPGGPP 616
P PPP PPPPP P G P
Sbjct: 941 GIPPPPPLPGAAIPPPPPLPGAGIP 965
Score = 38.9 bits (89), Expect = 0.027
Identities = 33/108 (30%), Positives = 37/108 (34%), Gaps = 12/108 (11%)
Query: 509 ATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPL 568
A P +P PG G L P+ G AP P L + + P S L
Sbjct: 233 AAPPTAVSPQPGAFLGLDRFLLGPSG--GAGEAPGSPDTEQALSALSDLPES-------L 283
Query: 569 PGSPEPPPAPPLPGDLP---PPPPPPPPPPGTDGPVPPPPPPPPPPPG 613
P P PP PG LP P P P D P P P PG
Sbjct: 284 AAEPREPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPG 331
Score = 37.0 bits (84), Expect = 0.10
Identities = 35/112 (31%), Positives = 39/112 (34%), Gaps = 12/112 (10%)
Query: 530 LAPAAEPA--PGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPP 587
L A EPA P A P P GL P +AP GSP+ A DLP
Sbjct: 226 LQGAEEPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAP---GSPDTEQALSALSDLPES 282
Query: 588 -------PPPPPPPPGTDGPVPPPPPPPPPPPGGPPDALGRRDSELGPGVKA 632
P PP P G P P P P + E GPG +A
Sbjct: 283 LAAEPREPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEA 334
Score = 33.5 bits (75), Expect = 1.1
Identities = 38/159 (23%), Positives = 52/159 (32%), Gaps = 41/159 (25%)
Query: 457 RRPPEPEKAPPA-APTRPSALELKVEELEEKGLIRILRGPGD-AVSIEILPVAVATPSGG 514
++PP P P + AP+ P+A + GPG+ A + G
Sbjct: 291 QQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGE 350
Query: 515 DAPTPGVPTGSPSPDLAPAA----------EP--------APGAAPPPPPPLPG------ 550
+ P GSP + AP EP AP AA P P P
Sbjct: 351 EDAFEDAPRGSPGEEWAPEVGEDAPQRLGEEPEEEAQGPDAPAAASLPGSPAPSQRCFKP 410
Query: 551 ---------------LPSPQEAPPSAPPQAPPLPGSPEP 574
L SP +P +P Q+P + PEP
Sbjct: 411 YPLITPCYIKTTTRQLSSPNHSPSQSPNQSPRIKRRPEP 449
>gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2)
interacting protein [Homo sapiens]
Length = 1211
Score = 161 bits (407), Expect = 4e-39
Identities = 124/462 (26%), Positives = 203/462 (43%), Gaps = 32/462 (6%)
Query: 558 PPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPP--PPPPGGP 615
PP +PP PPLP P + G P P PVPPPPPPP PP P P
Sbjct: 752 PPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLPPPVPCAP 811
Query: 616 PDALGRRDSELGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTELNDEKVLQEL-DM 674
P L G+ ++ + + L W ++ S+ GT++ +L ++ +L DM
Sbjct: 812 P--------MLSRGLGHRRSETSHMSVKRLRWEQVENSE--GTIWGQLGEDSDYDKLSDM 861
Query: 675 S---DFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAITLRKGNLGAER 731
D E F T+ + + ++ +A N +I L L
Sbjct: 862 VKYLDLELHFGTQKPA-----KPVPGPEPFRKKEVVEILSHKKAYNTSILLAHLKLSPAE 916
Query: 732 ICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSEEDRFMLCFSRI 791
+ Q + + + + L L L+ F P E R++ + LSE D+F+L +
Sbjct: 917 LRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQ---RYQAFREAPGRLSEPDQFVLQMLSV 973
Query: 792 PRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNSS 851
P R+ +L F + + + L + AS+ +K+S KL +ILE VLA GNY+N
Sbjct: 974 PEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAMGNYLNDG 1033
Query: 852 --KRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGS 909
K GF++ L L K+ D K T LH L K +++ +P+L GF DL + A
Sbjct: 1034 QPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQDLPTVPLAAK 1093
Query: 910 VSLDSVLADVRSLQRGL----ELTQREFVRQDD--CMVLKEFLRANSPTMDKLLADSKTA 963
V+ ++ +D+ L + + Q +D MV+ FL P + L + A
Sbjct: 1094 VNQRALTSDLADLHGTISEIQDACQSISPSSEDKFAMVMSSFLETAQPALRALDGLQREA 1153
Query: 964 QEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVE 1005
E + +FGE+ K T+ FF +F+ F+ +++A +++
Sbjct: 1154 MEELGKALAFFGEDSKATTSEAFFGIFAEFMSKFERALSDLQ 1195
Score = 36.2 bits (82), Expect = 0.18
Identities = 29/92 (31%), Positives = 33/92 (35%), Gaps = 7/92 (7%)
Query: 524 GSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAP------PLPGSPEPPPA 577
G+ S A P+P A P L G+ P E +P P P S E P
Sbjct: 572 GTVSKSRASPPGPSP-AVTTGPRTLSGVSWPSERLLPSPCYHPLCSGGLASPSSSESHPY 630
Query: 578 PPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPP 609
L P P P P P D P P P PP
Sbjct: 631 ASLDSSRAPSPQPGPGPICPDSPPSPDPTRPP 662
>gi|145309324 FH2 domain containing 1 [Homo sapiens]
Length = 1143
Score = 157 bits (398), Expect = 4e-38
Identities = 124/467 (26%), Positives = 205/467 (43%), Gaps = 38/467 (8%)
Query: 549 PGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLP---GDLPPPPPPPPPPPGTDGPVPPPP 605
PG Q PP+ PP PP PPP+PP + P PPPPPPPP +P P
Sbjct: 22 PGFMIGQTPPPAPPPPPPP------PPPSPPCSCSREECPSSPPPPPPPP-----LPGEP 70
Query: 606 PPPPPPPGGPPDALGRRDSELGPGVKAKKPIQTKFRMPLLNWVALKPSQITG--TVFTEL 663
P PPPPPG PP S LG K RM W + Q+ G ++T
Sbjct: 71 PIPPPPPGLPPTTHMNGYSHLG----------KKKRMRSFFWKTIPEEQVRGKTNIWTLA 120
Query: 664 NDEKVLQELDMSDFEEQF-----KTKSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNL 718
++ ++D EE F TKS P + + + ++A + T+++A R+ N+
Sbjct: 121 ARQEHHYQIDTKTIEELFGQQEDTTKSSLPRRGRTL--NSSFREAREEITILDAKRSMNI 178
Query: 719 AITLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPMEEL 778
I L++ I + I + G + L ++FLP E + F + + +L
Sbjct: 179 GIFLKQFKKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGD---VSKL 235
Query: 779 SEEDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQIL 838
S D F+ ++P R+ + F + L + + A + S ++L IL
Sbjct: 236 SLADSFLYGLIQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSIL 295
Query: 839 EIVLAFGNYMNS-SKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGF 897
+VL GN MN+ G A GF+L SL L + K+ LLH++ + +K L F
Sbjct: 296 HLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNF 355
Query: 898 HSDLHFLDKAGSVSLDSVLADVRSLQRGLELTQREFVRQDD-CMVLKEFLRANSPTMDKL 956
LH + K +SL++ A++ L + + R + C +++FL+ + +L
Sbjct: 356 SEKLHHVQKTARLSLENTEAELHLLFVRTKSLKENIQRDGELCQQMEDFLQFAIEKLREL 415
Query: 957 LADSKTAQEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQE 1003
+ Q+ +++++F E+ KT F +F F + KA ++
Sbjct: 416 ECWKQELQDEAYTLIDFFCEDKKTMKLDECFQIFRDFCTKFNKAVKD 462
Score = 42.4 bits (98), Expect = 0.002
Identities = 22/52 (42%), Positives = 26/52 (50%), Gaps = 7/52 (13%)
Query: 516 APTPGVPTGSPSPDLAPAAEPAPGAAPPPPPP----LPGLPSPQEAPPSAPP 563
AP P P PSP + + E P + PPPPPP P +P P PP PP
Sbjct: 33 APPPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPP---PPGLPP 81
Score = 30.8 bits (68), Expect = 7.4
Identities = 44/191 (23%), Positives = 67/191 (35%), Gaps = 20/191 (10%)
Query: 405 QEQVALLTERLRDAENESMAKIAELEKQLSQARKELETLRERFSESTAMGASRRPPEPEK 464
Q VA L +ENESM K+ + K A R E ++ G S+ PP
Sbjct: 884 QGAVAKSVRTLTASENESMRKVMPITKSSRGA-------GWRRPELSSRGPSQNPP---S 933
Query: 465 APPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPV----AVATPSGGDAPTPG 520
+ +R +++ EE+ L R G +P+ + PS P
Sbjct: 934 STDTVWSRQNSVRRASTGAEEQRLPRGSSGSSSTRPGRDVPLQPRGSFKKPSA--KPLRN 991
Query: 521 VPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPL 580
+P P + A +P P P +PS P P+ P + + +
Sbjct: 992 LPRQKPEENKTCRAHSEGPESPKEEPKTPSVPS----VPHELPRVPSFARNTVASSSRSM 1047
Query: 581 PGDLPPPPPPP 591
DLPP P
Sbjct: 1048 RTDLPPVAKAP 1058
Score = 30.4 bits (67), Expect = 9.6
Identities = 49/201 (24%), Positives = 72/201 (35%), Gaps = 34/201 (16%)
Query: 437 RKELETLRERFSESTAMGASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRI-LRGP 495
R+ + LR+R+SE ++G+++ P P P AL +K EL GL + L+G
Sbjct: 639 RQGVSVLRKRYSEPVSLGSAQSP----------PLSPLALGIKEHEL-VTGLAQFNLQGS 687
Query: 496 GDAVSIEILPVAVATPSGGDAPTPGVP--TGSPSPDLAPAAEPAPGAAPPPPPPLPGLPS 553
L ++ +P ++ P + S L P A G+ P L
Sbjct: 688 QGMEETSQLTLSDFSPMELESVGHRGPQSLSASSSSLTPMGRDALGSLS------PALED 741
Query: 554 PQEAPPSAPPQAPPLPGSPEPPPAPPLP----GDLPPPPPPPPPPPGTDGPVPPPPPPPP 609
+ AP A GS +P P P D GTD
Sbjct: 742 GKAAPDEPGSAALGSVGSSDPENKDPRPLFCISDTTDCSLTLDCSEGTDS---------- 791
Query: 610 PPPGGPPDALGRRDSELGPGV 630
P GG P+ G D + GV
Sbjct: 792 RPRGGDPEEGGEGDGSMSSGV 812
>gi|58331242 formin homology 2 domain containing 3 [Homo sapiens]
Length = 1439
Score = 130 bits (326), Expect = 9e-30
Identities = 125/487 (25%), Positives = 213/487 (43%), Gaps = 47/487 (9%)
Query: 581 PGDLPPPPP-----PPPPPPGTDGPVPPPPPP-----PPPPPGGPPDALGRRDSELGPGV 630
PG PPPPP PPPPPP +PPPP P PPPP P LG G
Sbjct: 844 PGPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPVFNAPQGLGWSQVPRGQPT 903
Query: 631 --KAKKPIQTKFR-MPLLNWVALKPSQITGTVFTELNDEKVLQELDMSDFEEQFKTKSQG 687
K KK I+ + + +W + ++++L KV D S E F++KS+
Sbjct: 904 FTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLEPIKV----DTSRLEHLFESKSK- 958
Query: 688 PSLDLSALKSKAAQKAPSKATLIEANRAKNLAITLRKGNLGAERICQ-AIEAYDLQALGL 746
+LS K AA + ++++ R+ + I L L R + AI +D AL
Sbjct: 959 ---ELSVSKKTAADGKRQEIIVLDSKRSNAINIGLTV--LPPPRTIKIAILNFDEYALNK 1013
Query: 747 DFLELLMRFLPTEYERSLITRFEREQRPMEELSEEDRFMLCFSRIPRLPERMTTLTFLGN 806
+ +E ++ +PT+ E+ I + P L ++F+L S I L R+ F +
Sbjct: 1014 EGIEKILTMIPTDEEKQKIQEAQLAN-PEIPLGSAEQFLLTLSSISELSARLHLWAFKMD 1072
Query: 807 FPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRLQSLDA 866
+ T + + L + ++++ L IL +LA GN++N + A F L L+
Sbjct: 1073 YETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTN---AKAFELSYLEK 1129
Query: 867 LLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLADVRSLQRGL 926
+ E+K T KQ+LLH++ ++ E +P + +S++ + ++ V D + ++ ++R
Sbjct: 1130 VPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQDNLCQMERRC 1189
Query: 927 ELT---QREFVRQDDCMVLK----EFLRANSPTMDKLLADSKTAQEAFESVVEYFGENP- 978
+ + + + + VLK EFL+ + + L + F S + + G P
Sbjct: 1190 KASWDHLKAIAKHEMKPVLKQRMSEFLKDCAERIIILKIVHRRIINRFHSFLLFMGHPPY 1249
Query: 979 --KTTSPGLFFSLFSRFIKAYKKAEQEVEQWKKEAAAQEAGADTPGK---------GEPP 1027
+ + F + S F Y+ + V Q K++ A T GK G P
Sbjct: 1250 AIREVNINKFCRIISEFALEYRTTRERVLQQKQKRANHRERNKTRGKMITDSGKFSGSSP 1309
Query: 1028 APKSPPK 1034
AP S P+
Sbjct: 1310 APPSQPQ 1316
>gi|118572599 formin homology 2 domain containing 1 [Homo sapiens]
Length = 1164
Score = 119 bits (298), Expect = 2e-26
Identities = 176/781 (22%), Positives = 283/781 (36%), Gaps = 159/781 (20%)
Query: 379 DNIFDVGALLEDTETKNAVLEHMEELQEQVALLTE--------RLRDAENESMAKIAELE 430
D+ +DV LE + V H+ V L T+ +L D + E
Sbjct: 292 DSFYDVTDALEQQGMEALVQRHLGTAGTDVDLRTQLVLYENALKLEDGDIEEAPGAGGRR 351
Query: 431 KQLSQARKELETLRERFSESTAMGASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIR 490
++ + +E + R G R PEP PA+P P++
Sbjct: 352 ERRKPSSEEGKRSRRSLEGG---GCPARAPEPGPTGPASPVGPTSSTGPA---------- 398
Query: 491 ILRGPGDA---------VSIEILPVAVATPSG---------------------------- 513
+L GP + S+ + P PS
Sbjct: 399 LLTGPASSPVGPPSGLQASVNLFPTISVAPSADTSSERSIYKARFLENVAAAETEKQVAL 458
Query: 514 --GDAPT-----PGVPTGSP-------SPDLAPAAEPAPGAAP----------PPPPPLP 549
G A T P G P SP+ APAA AP P P P
Sbjct: 459 AQGRAETLAGAMPNEAGGHPDARQLWDSPETAPAARTPQSPAPCVLLRAQRSLAPEPKEP 518
Query: 550 GLPSPQEAPP--SAPPQAPPLP-------------------------GSPEPPPAPPLP- 581
+P+ +A P P +AP L G P P+PPLP
Sbjct: 519 LIPASPKAEPIWELPTRAPRLSIGDLDFSDLGEDEDQDMLNVESVEAGKDIPAPSPPLPL 578
Query: 582 --GDLPPPPPPPPPPPGTDGPVPPPPPPP--PPPPGGPPDALGRRDSELGPGVKAKKPIQ 637
G PPPP PPPPP GP PPPPP P P P PD+ S L K K
Sbjct: 579 LSGVPPPPPLPPPPP--IKGPFPPPPPLPLAAPLPHSVPDS-----SALPTKRKTVKLFW 631
Query: 638 TKFRMPLLNWVALKPSQITGTVFTELNDEKVLQELDMSDFEEQFKTKSQGPSLDLSALKS 697
+ ++ + V+ T++ L+ V D + E F+++++ L S
Sbjct: 632 RELKLAGGHGVSASRFGPCATLWASLDPVSV----DTARLEHLFESRAK------EVLPS 681
Query: 698 KAAQKAPSKATLIEANRAKNLAITLRKGNLGAERICQ-AIEAYDLQALGLDFLELLMRFL 756
K A + T + + N AI + L + + A+ +D A+ D +E L+ +
Sbjct: 682 KKAGEGRRTMTTVLDPKRSN-AINIGLTTLPPVHVIKAALLNFDEFAVSKDGIEKLLTMM 740
Query: 757 PTEYERSLITRFEREQRPMEELSEEDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMP 816
PTE ER I + P L + F++ + I L R+ F ++ + +
Sbjct: 741 PTEEERQKIEEAQL-ANPDIPLGPAENFLMTLASIGGLAARLQLWAFKLDYDSMEREIAE 799
Query: 817 QLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRLQSLDALLEMKSTDRK 876
L + + + R IL +LA GN++N S+ + GF L L+ + E+K T R+
Sbjct: 800 PLFDLKVGMEQLVQNATFRCILATLLAVGNFLNGSQ---SSGFELSYLEKVSEVKDTVRR 856
Query: 877 QTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLADVRSLQ---RGLELTQREF 933
Q+LLH+L ++ + P+ + +S++ L + V + + ++ L+ R E + R
Sbjct: 857 QSLLHHLCSLVLQTRPESSDLYSEIPALTRCAKVDFEQLTENLGQLERRSRAAEESLRSL 916
Query: 934 VRQDDCMVLK----EFLRANSPTMDKLLADSKTAQEAFESVVEYFGENPKTTSP---GLF 986
+ + L+ FL + + L + F + + Y G P+ F
Sbjct: 917 AKHELAPALRARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYLGYTPQAAREVRIMQF 976
Query: 987 FSLFSRFIKAYKKAEQEVEQWKKEAAAQEAGADTPGK------------GEPPAPKSPPK 1034
F Y+ + V Q +++ A T G+ GE P+ S P
Sbjct: 977 CHTLREFALEYRTCRERVLQQQQKQATYRERNKTRGRMITETEKFSGVAGEAPSNPSVPV 1036
Query: 1035 A 1035
A
Sbjct: 1037 A 1037
>gi|11386183 WAS protein family, member 2 [Homo sapiens]
Length = 498
Score = 103 bits (258), Expect = 7e-22
Identities = 65/168 (38%), Positives = 72/168 (42%), Gaps = 22/168 (13%)
Query: 456 SRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGD 515
S P P + P P+ V+ GL GP + +V +PS
Sbjct: 254 SASSPSPSFSEDNLPPPPAEFSYPVDNQRGSGLA----GPKRS--------SVVSPSH-- 299
Query: 516 APTPGVPTGSP---SPDLAPAAEPAPGAAP----PPPPPLPGLPSPQEAPPSAPPQAPPL 568
P P P GSP P AP P P P PPPPP G SP PP +PP PP
Sbjct: 300 -PPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPH 358
Query: 569 PGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGPP 616
P PPP PP P P PPPP T G PPPPPPPPP P PP
Sbjct: 359 PDFAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPPPPPPGPPPPP 406
Score = 35.8 bits (81), Expect = 0.23
Identities = 26/85 (30%), Positives = 30/85 (35%), Gaps = 3/85 (3%)
Query: 535 EPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPP 594
E ++ PPPP SP +P + PP P P L P
Sbjct: 239 ENVDASSYPPPPQSDSASSP--SPSFSEDNLPPPPAEFSYPVDNQRGSGLAGPKRSSVVS 296
Query: 595 PGTDGPVPPPPPPPPPPPG-GPPDA 618
P P PP PP P PG PP A
Sbjct: 297 PSHPPPAPPLGSPPGPKPGFAPPPA 321
Score = 30.4 bits (67), Expect = 9.6
Identities = 12/21 (57%), Positives = 12/21 (57%)
Query: 10 QPAGPAAPPPKQPAPPKQPMP 30
QP G A PPP P PP P P
Sbjct: 385 QPTGGAPPPPPPPPPPGPPPP 405
>gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo
sapiens]
Length = 505
Score = 103 bits (256), Expect = 1e-21
Identities = 54/112 (48%), Positives = 56/112 (50%), Gaps = 5/112 (4%)
Query: 511 PSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQA--PPL 568
PS G P P P + P PA APPPPP +P PPS P A PP
Sbjct: 282 PSRGGPPPPPPPPHNSGPPPPPARGRG---APPPPPSRAPTAAPPPPPPSRPSVAVPPPP 338
Query: 569 PGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGPPDALG 620
P PPP P LP P PPPPPP GPV PPPPPPPPPP GPP G
Sbjct: 339 PNRMYPPPPPALPSSAPSGPPPPPPSVLGVGPVAPPPPPPPPPPPGPPPPPG 390
Score = 68.2 bits (165), Expect = 4e-11
Identities = 36/75 (48%), Positives = 36/75 (48%), Gaps = 16/75 (21%)
Query: 561 APPQAPPLPGSPEPPPAPPLPGDLPPPPP-----PPPPPPGTDGPVPPPPPP-------P 608
APP PP G P PPP PP PPPP PPPPP PPPPPP P
Sbjct: 276 APPPPPPSRGGPPPPPPPPHNSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPSVAVP 335
Query: 609 PPPPG----GPPDAL 619
PPPP PP AL
Sbjct: 336 PPPPNRMYPPPPPAL 350
Score = 66.6 bits (161), Expect = 1e-10
Identities = 40/102 (39%), Positives = 45/102 (44%), Gaps = 14/102 (13%)
Query: 511 PSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLP- 569
P+ G P P+ +P+ P P A PPPPP P P A PS+ P PP P
Sbjct: 303 PARGRGAPPPPPSRAPTAAPPPPPPSRPSVAVPPPPPNRMYPPPPPALPSSAPSGPPPPP 362
Query: 570 ---------GSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVP 602
P PPP PP PG PPPPP P G D VP
Sbjct: 363 PSVLGVGPVAPPPPPPPPPPPG---PPPPPGLPSDG-DHQVP 400
Score = 62.8 bits (151), Expect = 2e-09
Identities = 41/99 (41%), Positives = 46/99 (46%), Gaps = 17/99 (17%)
Query: 505 PVAVATPSGGDAPTPG-VPTGSPSPDLAPAAEPAPGAAPPPP-----PPLPGLPSPQEAP 558
P A G P P PT +P P P + P+ PPPP PP P LPS +
Sbjct: 300 PPPPARGRGAPPPPPSRAPTAAPPPP--PPSRPSVAVPPPPPNRMYPPPPPALPS---SA 354
Query: 559 PSAPPQAPPL-----PGSPEPPPAPPLPGDLPPPPPPPP 592
PS PP PP P +P PPP PP P PPPPP P
Sbjct: 355 PSGPPPPPPSVLGVGPVAPPPPPPPP-PPPGPPPPPGLP 392
Score = 47.8 bits (112), Expect = 6e-05
Identities = 25/55 (45%), Positives = 27/55 (49%), Gaps = 10/55 (18%)
Query: 590 PPPPPPGTDGPVPPPPPPP----PPPP-----GGPPDALGRRDSELGPGVKAKKP 635
PPPPPP GP PPPPPPP PPPP G PP R + P +P
Sbjct: 277 PPPPPPSRGGP-PPPPPPPHNSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRP 330
Score = 46.2 bits (108), Expect = 2e-04
Identities = 38/120 (31%), Positives = 45/120 (37%), Gaps = 18/120 (15%)
Query: 452 AMGASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATP 511
A G PP P +AP AAP P V + R+ P A+ + P
Sbjct: 304 ARGRGAPPPPPSRAPTAAPPPPPPSRPSVA-VPPPPPNRMYPPPPPALPS-------SAP 355
Query: 512 SGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGS 571
SG P P V + P A P P PPPPP PG P P P Q P G+
Sbjct: 356 SGPPPPPPSVL------GVGPVAPPPP----PPPPPPPGPPPPPGLPSDGDHQVPTTAGN 405
>gi|153792074 proline rich 12 [Homo sapiens]
Length = 2036
Score = 103 bits (256), Expect = 1e-21
Identities = 59/131 (45%), Positives = 67/131 (51%), Gaps = 17/131 (12%)
Query: 492 LRGPGDAVSIEILPVAVATPSGGDAPTPGVPT----GSPSPDLAPAAEPAPGAAPPPPPP 547
L GP D + + P+A A G P PG+P+ G+P P P E P PP PPP
Sbjct: 1410 LAGPKDTSTPDGPPLAPAAAVPGPPPLPGLPSANSNGTPEP---PLLEEKP---PPTPPP 1463
Query: 548 LPGLPSPQEAPPSAPPQAPPLPGSPEPPP-APPLPGDLPPPPPPPPPPPGTDGPVPPPPP 606
P +PQ PP PP PP P P PPP P P PPPP PPPPPP P PPPPP
Sbjct: 1464 AP---TPQPQPPPPPP--PPQPALPSPPPLVAPTPSSPPPPPLPPPPPPAMPSP-PPPPP 1517
Query: 607 PPPPPPGGPPD 617
P P PP+
Sbjct: 1518 PAAAPLAAPPE 1528
Score = 77.8 bits (190), Expect = 5e-14
Identities = 58/173 (33%), Positives = 69/173 (39%), Gaps = 12/173 (6%)
Query: 452 AMGASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATP 511
A G +PP P P+ L +E E +GL P + E+ P
Sbjct: 1319 ARGLQPQPPATPAVPHPPPSGAFGLGGALEAAESEGLGLGCPSPCKRLDEELKRNLETLP 1378
Query: 512 SGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAP----PQAPP 567
S V + + DL + A A PP P S + PP AP P PP
Sbjct: 1379 SFSSDEEDSV---AKNRDLQESISSAISALDDPPLAGPKDTSTPDGPPLAPAAAVPGPPP 1435
Query: 568 LPGSPEP----PPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGPP 616
LPG P P PPL + PPP PPP P P P PPPPPP P P PP
Sbjct: 1436 LPGLPSANSNGTPEPPLLEEKPPPTPPPAPTPQPQPP-PPPPPPQPALPSPPP 1487
Score = 59.7 bits (143), Expect = 1e-08
Identities = 44/129 (34%), Positives = 51/129 (39%), Gaps = 11/129 (8%)
Query: 513 GGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSP 572
GG A G P + +P GA PPP PP P P A P PG
Sbjct: 955 GGGAADDYGKAGPPEDE----GDPKAGAGPPPGPPAYDPYGPY-CPGRASGAGPETPGLG 1009
Query: 573 EPPPAPPLPGDLPPPPPPPPPPPGTDGP---VPPPPPPPPPPPGGPPDALGRRDSELGPG 629
P PP +LP P GP PPPPPPPPPPP + G S +
Sbjct: 1010 LDPNKPP---ELPSTVNAEPLGLIQSGPHQAAPPPPPPPPPPPAPASEPKGGLTSPIFCS 1066
Query: 630 VKAKKPIQT 638
K KK ++T
Sbjct: 1067 TKPKKLLKT 1075
Score = 57.8 bits (138), Expect = 6e-08
Identities = 33/85 (38%), Positives = 34/85 (40%), Gaps = 10/85 (11%)
Query: 541 APPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPP------- 593
+PPPPPP P P LP PPP LP L P P P
Sbjct: 763 SPPPPPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVGVH 822
Query: 594 ---PPGTDGPVPPPPPPPPPPPGGP 615
P DG PPPPPPPPPP P
Sbjct: 823 LLEPATRDGAPQPPPPPPPPPPPMP 847
Score = 52.8 bits (125), Expect = 2e-06
Identities = 44/148 (29%), Positives = 53/148 (35%), Gaps = 50/148 (33%)
Query: 517 PTPGVPTGSPSPD---LAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPL----- 568
P P + P+P L P PPPPP L LPS PS P A +
Sbjct: 767 PPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQL--LPSVLSHAPSPSPSASKVGVHLL 824
Query: 569 -PGSPEPPPAPPLPGDLPPPPPPPPP------------------------------PPGT 597
P + + P PP PPPPPPPPP PPG
Sbjct: 825 EPATRDGAPQPP-----PPPPPPPPPMPLQLEAHLRSHGLEPAAPSPRLRPEESLDPPGA 879
Query: 598 D----GPVPPPPPPPPPPPGGPPDALGR 621
G + P PP P GPP++ G+
Sbjct: 880 MQELLGALEPLPPAPGDTGVGPPNSEGK 907
Score = 51.6 bits (122), Expect = 4e-06
Identities = 51/161 (31%), Positives = 59/161 (36%), Gaps = 21/161 (13%)
Query: 454 GASRRP-PEPEKAPPAAPTRPSALELKVEELEEKGLIRILR-----GPGDAVSIEILPVA 507
GA R P P+ KAP P + + EE+ + G D P
Sbjct: 911 GAYRSPSPQGTKAPRFVPLTSICFPDSLLQDEERSFFPTMEEMFGGGAADDYGKAGPPED 970
Query: 508 VATPSGGDAPTPGVPTGSP----SPDLAPAAEP-APGAAPPPPPPLPGLPSPQEAPPSAP 562
P G P PG P P P A A P PG P P P LPS A P
Sbjct: 971 EGDPKAGAGPPPGPPAYDPYGPYCPGRASGAGPETPGLGLDPNKP-PELPSTVNAEPLGL 1029
Query: 563 PQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPP--GTDGPV 601
Q+ P +P PPP P PPPPP P P G P+
Sbjct: 1030 IQSGPHQAAPPPPP----P---PPPPPAPASEPKGGLTSPI 1063
Score = 51.2 bits (121), Expect = 5e-06
Identities = 54/182 (29%), Positives = 68/182 (37%), Gaps = 38/182 (20%)
Query: 453 MGASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPS 512
+GA + P P A T+P+ GL+ GP LP+ + P
Sbjct: 756 LGAFLQKSPPPPPPTAQSTQPTP----------HGLLLEAGGPD-------LPLVLPPPP 798
Query: 513 GGDAPTPGVPTGSPSPD--------LAPAA-EPAPGAAPPPPPPLPGLPSPQEA------ 557
P+ SPSP L PA + AP PPPPPP P +P EA
Sbjct: 799 PQLLPSVLSHAPSPSPSASKVGVHLLEPATRDGAPQPPPPPPPPPPPMPLQLEAHLRSHG 858
Query: 558 -PPSAP-PQAPPLPGSPEPPPAPPLPGDLPPPPPPPPP----PPGTDGPVPPPPPPPPPP 611
P+AP P+ P P L G L P PP P PP ++G P P P
Sbjct: 859 LEPAAPSPRLRPEESLDPPGAMQELLGALEPLPPAPGDTGVGPPNSEGKDPAGAYRSPSP 918
Query: 612 PG 613
G
Sbjct: 919 QG 920
Score = 48.9 bits (115), Expect = 3e-05
Identities = 41/122 (33%), Positives = 48/122 (39%), Gaps = 37/122 (30%)
Query: 513 GGDAP----TPGVPTGSPSPDLAPAAEPAPGAAPPPPP------PLP-------GLPSPQ 555
GG+ P T V G+ + +L + +P PPPPP P P G P
Sbjct: 735 GGETPEGLATSVVHYGAGAKELGAFLQKSP---PPPPPTAQSTQPTPHGLLLEAGGPDLP 791
Query: 556 EAPPSAPPQAPPLPGSPEPPPAP-----------PLPGDLPPPPPPPPPPPGTDGPVPPP 604
P PPQ P S P P+P P D P PPPPPPPP PPP
Sbjct: 792 LVLPPPPPQLLPSVLSHAPSPSPSASKVGVHLLEPATRDGAPQPPPPPPPP------PPP 845
Query: 605 PP 606
P
Sbjct: 846 MP 847
Score = 45.1 bits (105), Expect = 4e-04
Identities = 45/172 (26%), Positives = 57/172 (33%), Gaps = 14/172 (8%)
Query: 447 FSESTAMGASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPV 506
F S+A+ A + P P P+ L +++ L P D + ++
Sbjct: 142 FPSSSALSAYQHPASFGSRPFPVPS-----SLSLQDPPFSPPANGLLSPHDVLHLKPSQA 196
Query: 507 AVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAP 566
S G G P+ L PA P PP PPP P P + A A
Sbjct: 197 PTVPSSLGFERLAGGGVLGPA-GLGPAQTPPYRPGPPDPPP-PPRHLPTQFNLLASSSAA 254
Query: 567 PLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTD-------GPVPPPPPPPPPP 611
P G P PPPP P D P PPPPPPP
Sbjct: 255 AAAAEQSSPQLYNFSGAAPGPPPPERALPRQDTVIKHYQRPASAQPPPPPPP 306
Score = 41.2 bits (95), Expect = 0.005
Identities = 25/64 (39%), Positives = 30/64 (46%), Gaps = 2/64 (3%)
Query: 546 PPLPGLPSPQ-EAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPP 604
PP+P S Q + P SA + P P +P PPP P P + PP P T P PP
Sbjct: 1670 PPVPVRRSGQAKNPVSAGGSSAPPPKAPAPPPKPETP-EKTTSEKPPEQTPETAMPEPPA 1728
Query: 605 PPPP 608
P P
Sbjct: 1729 PEKP 1732
Score = 40.0 bits (92), Expect = 0.012
Identities = 28/71 (39%), Positives = 30/71 (42%), Gaps = 5/71 (7%)
Query: 542 PPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPV 601
PP PP GL SP + P QAP +P S G L P P P P
Sbjct: 173 PPFSPPANGLLSPHDVLHLKPSQAPTVPSSLGFERLAG-GGVLGPAGLGPAQTP----PY 227
Query: 602 PPPPPPPPPPP 612
P PP PPPPP
Sbjct: 228 RPGPPDPPPPP 238
Score = 39.7 bits (91), Expect = 0.016
Identities = 23/70 (32%), Positives = 30/70 (42%), Gaps = 3/70 (4%)
Query: 517 PTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPP 576
P P +G ++ AP P PPP P +P++ PP+ P PEPP
Sbjct: 1671 PVPVRRSGQAKNPVSAGGSSAPPPKAPAPPPKP--ETPEKTTSEKPPEQTPETAMPEPP- 1727
Query: 577 APPLPGDLPP 586
AP P L P
Sbjct: 1728 APEKPSLLRP 1737
Score = 38.9 bits (89), Expect = 0.027
Identities = 41/139 (29%), Positives = 53/139 (38%), Gaps = 28/139 (20%)
Query: 449 ESTAMGASRRPPE--PEKA--PPAAPTRPSALELKVEELEEKGLI----RILRGPGDAVS 500
E+ S +PPE PE A P AP +PS L VE+ +EK + R LRG
Sbjct: 1704 ETPEKTTSEKPPEQTPETAMPEPPAPEKPSLLR-PVEKEKEKEKVTRGERPLRGER---- 1758
Query: 501 IEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPP-------PPLPGLPS 553
AT P + TG P+ P A P A PPP G +
Sbjct: 1759 --------ATSGRQTRPERSLATGQPATSRLPKARPTKVKAEPPPKKRKKWLKEAGGNAT 1810
Query: 554 PQEAPPSAPPQAPPLPGSP 572
PP + + PG+P
Sbjct: 1811 AGGGPPGSSSDSESSPGAP 1829
Score = 37.4 bits (85), Expect = 0.079
Identities = 25/76 (32%), Positives = 35/76 (46%), Gaps = 7/76 (9%)
Query: 5 AGSAEQPA---GPAAPPPKQPAPPKQPMPAAGELEERFNRALNCMNLP----PDKVQLLS 57
+G A+ P G +APPPK PAPP +P E+ +P P+K LL
Sbjct: 1677 SGQAKNPVSAGGSSAPPPKAPAPPPKPETPEKTTSEKPPEQTPETAMPEPPAPEKPSLLR 1736
Query: 58 QYDNEKKWELICDQER 73
+ EK+ E + ER
Sbjct: 1737 PVEKEKEKEKVTRGER 1752
Score = 37.4 bits (85), Expect = 0.079
Identities = 21/62 (33%), Positives = 26/62 (41%), Gaps = 7/62 (11%)
Query: 514 GDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPE 573
G A P GS +P P APPP P P + ++ P P A P P +PE
Sbjct: 1678 GQAKNPVSAGGSSAP-------PPKAPAPPPKPETPEKTTSEKPPEQTPETAMPEPPAPE 1730
Query: 574 PP 575
P
Sbjct: 1731 KP 1732
Score = 36.6 bits (83), Expect = 0.13
Identities = 54/213 (25%), Positives = 66/213 (30%), Gaps = 66/213 (30%)
Query: 452 AMGASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATP 511
A G + RPP PP + P L G A + + A
Sbjct: 399 AAGGATRPP-----PPRSTATPKCQSLG----------------GPAAAYATGKASGAGG 437
Query: 512 SGGDAPTPGVPTGSPSPDL---------------APAAEPAPGAAPPPPPPLPGLPSPQE 556
+GG A +PG P G P AP+ P P PPP PGL + Q
Sbjct: 438 AGGQAYSPGQPQGLLGPQAYGQGFGGGQAQDLSKAPSYSGGPPQPPSGPPP-PGLATCQS 496
Query: 557 -APPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPP-------PPPPPGTDG--------- 599
+P Q + G P P PA G LP P P G G
Sbjct: 497 YSPDQLQGQLYGVQGEPYPGPAAHSQG-LPTASPSLSYSTGHSPALSGHGGGWGPSSLGG 555
Query: 600 -----------PVPPPPPPPPPPPGGPPDALGR 621
P+ PP PP G P A G+
Sbjct: 556 GGEASPSHIIRPLQSPPATGRPPGVGSPGAPGK 588
Score = 36.2 bits (82), Expect = 0.18
Identities = 20/56 (35%), Positives = 22/56 (39%), Gaps = 9/56 (16%)
Query: 544 PPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDG 599
PP GL P P S PP P P+PP P + P PPP G G
Sbjct: 1296 PPLYQAGLTPPLSPPKSVPPSVPARGLQPQPPATPAV---------PHPPPSGAFG 1342
Score = 32.7 bits (73), Expect = 1.9
Identities = 53/222 (23%), Positives = 67/222 (30%), Gaps = 63/222 (28%)
Query: 454 GASRRPPEPEKAPPAAPT------RPSALELKVEELEEKGLIRILRGPGDAVSIEILPVA 507
GA+ PP PE+A P T RP++ + L L G S+
Sbjct: 270 GAAPGPPPPERALPRQDTVIKHYQRPASAQPPPPPPPAHALQHYLSCGGSYPSMGHRANL 329
Query: 508 VATPSGGDAPTPGV-------PTGSPSPDLAPAAEP------------------------ 536
+P GG P+PG P+G+ + A P
Sbjct: 330 ACSPLGGGEPSPGAGEPSKAGPSGATAGASGRATGPEAAGGGGAGGGGGGYRPIIQSPGY 389
Query: 537 ----------APGAAPPPPPPLPGLPSPQE----APPSAPPQAPPLPGSPEPPPAPPLPG 582
A GA PPPP P Q A A +A G+ +P P
Sbjct: 390 KTGKGGYGAAAGGATRPPPPRSTATPKCQSLGGPAAAYATGKASGAGGAGGQAYSPGQPQ 449
Query: 583 DLPPPPP-----------PPPPPPGTDGPVPPPPPPPPPPPG 613
L P P G PP PP PPPPG
Sbjct: 450 GLLGPQAYGQGFGGGQAQDLSKAPSYSGG-PPQPPSGPPPPG 490
Score = 32.0 bits (71), Expect = 3.3
Identities = 14/29 (48%), Positives = 15/29 (51%)
Query: 7 SAEQPAGPAAPPPKQPAPPKQPMPAAGEL 35
S P P PPP P+PP P PAA L
Sbjct: 1495 SPPPPPLPPPPPPAMPSPPPPPPPAAAPL 1523
Score = 31.6 bits (70), Expect = 4.3
Identities = 18/49 (36%), Positives = 19/49 (38%), Gaps = 5/49 (10%)
Query: 566 PPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGG 614
PPL + PP P P PP P G P P P PPP G
Sbjct: 1296 PPLYQAGLTPPLSP-----PKSVPPSVPARGLQPQPPATPAVPHPPPSG 1339
Score = 31.2 bits (69), Expect = 5.6
Identities = 27/68 (39%), Positives = 29/68 (42%), Gaps = 11/68 (16%)
Query: 578 PPL--PGDLPPPPPPPPPPPGTDG----PVPPPPP--PPPPPPG--GPPDALGRRDSELG 627
PPL G PP PP PP P PP P P PPP G G AL +SE G
Sbjct: 1296 PPLYQAGLTPPLSPPKSVPPSVPARGLQPQPPATPAVPHPPPSGAFGLGGALEAAESE-G 1354
Query: 628 PGVKAKKP 635
G+ P
Sbjct: 1355 LGLGCPSP 1362
Score = 30.8 bits (68), Expect = 7.4
Identities = 18/60 (30%), Positives = 22/60 (36%), Gaps = 4/60 (6%)
Query: 562 PPQAPPLP----GSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGPPD 617
P PP+P G + P + PP P PPP P T PP P P+
Sbjct: 1666 PWHRPPVPVRRSGQAKNPVSAGGSSAPPPKAPAPPPKPETPEKTTSEKPPEQTPETAMPE 1725
Score = 30.4 bits (67), Expect = 9.6
Identities = 54/232 (23%), Positives = 77/232 (33%), Gaps = 58/232 (25%)
Query: 424 AKIAELEKQLSQARKELETLRERFSESTAMGASRRPP--EPEKAPPAAPTRPSALELKVE 481
AKI E+E++ + + F +S R PP + PP +P + +
Sbjct: 1265 AKIKEVEEKQPEMKSGFMASFLDFLKS----GKRHPPLYQAGLTPPLSPPKSVPPSVPAR 1320
Query: 482 ELEEKGLIRILRGPGDAVSIEILPVAVATPSGGD---APTPGVPTGSPSP------DLAP 532
L+ + P ++ P + A GG A + G+ G PSP +L
Sbjct: 1321 GLQPQ--------PPATPAVPHPPPSGAFGLGGALEAAESEGLGLGCPSPCKRLDEELKR 1372
Query: 533 AAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPP 592
E P + + QE+ SA + +PP A P P PP P
Sbjct: 1373 NLETLPSFSSDEEDSVAKNRDLQESISSA------ISALDDPPLAGPKDTSTPDGPPLAP 1426
Query: 593 PPPGTDGPVP---------------------PPPPPPP-------PPPGGPP 616
GP P PPP PPP PPP PP
Sbjct: 1427 AA-AVPGPPPLPGLPSANSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPPPP 1477
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 98.6 bits (244), Expect = 3e-20
Identities = 82/235 (34%), Positives = 97/235 (41%), Gaps = 63/235 (26%)
Query: 389 EDTETKNAVLEHMEELQEQVALLTERLRDAENESMAKIAELEKQLSQARKELETLRERFS 448
E E + E E L+ Q ERL E + + E+Q Q R+ LE L
Sbjct: 189 EQLERERQERERQERLERQ-----ERLERQERLERQERLDRERQERQERERLERLERERQ 243
Query: 449 ESTAMGASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAV 508
E R +L+ E+LE + RI S P +V
Sbjct: 244 E----------------------RERQEQLEREQLEWERERRI--------SSAAAPASV 273
Query: 509 ATPSG---GD--APTPGVPTGSPSPDLAPAAEPAPGA------APPPPPPLPGLPSPQEA 557
TP GD A PG+ S PA P+ APPPPPPLP P P +A
Sbjct: 274 ETPLNSVLGDSSASEPGLQAASQ-----PAETPSQQGIVLGPLAPPPPPPLP--PGPAQA 326
Query: 558 PPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPP 612
+ PP P PPP PPLP PPPPPPPPP P VPPPPPPPP PP
Sbjct: 327 SVALPPP-------PGPPPPPPLPSTGPPPPPPPPPLP---NQVPPPPPPPPAPP 371
Score = 64.7 bits (156), Expect = 5e-10
Identities = 71/237 (29%), Positives = 92/237 (38%), Gaps = 35/237 (14%)
Query: 387 LLEDTETKNAVLEHME-ELQEQVALLTERLRDAENESMAKIAELEKQLSQARKELETLRE 445
L E K E +E E E+ L ERL E E + + ++QL + R+E E +E
Sbjct: 147 LQEQQRQKELERERLERERMERERLERERL---ERERLERERLEQEQLERERQERER-QE 202
Query: 446 RFSESTAMGASRRPPEPEKAPPAAPTRPSA--LELKVEELEEKGLIRILRGPGDAVSIEI 503
R + R E+ R LE E +E+ L E
Sbjct: 203 RLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERER 262
Query: 504 LPVAVATPSGGDAPTPGV--PTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAP--P 559
+ A P+ + P V + + P L A++PA PS Q P
Sbjct: 263 RISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAE------------TPSQQGIVLGP 310
Query: 560 SAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGPP 616
APP PPLP P LPPPP PPPPPP +P PPPPPPP PP
Sbjct: 311 LAPPPPPPLPPGPAQASVA-----LPPPPGPPPPPP-----LPSTGPPPPPPP--PP 355
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 98.6 bits (244), Expect = 3e-20
Identities = 82/235 (34%), Positives = 97/235 (41%), Gaps = 63/235 (26%)
Query: 389 EDTETKNAVLEHMEELQEQVALLTERLRDAENESMAKIAELEKQLSQARKELETLRERFS 448
E E + E E L+ Q ERL E + + E+Q Q R+ LE L
Sbjct: 189 EQLERERQERERQERLERQ-----ERLERQERLERQERLDRERQERQERERLERLERERQ 243
Query: 449 ESTAMGASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAV 508
E R +L+ E+LE + RI S P +V
Sbjct: 244 E----------------------RERQEQLEREQLEWERERRI--------SSAAAPASV 273
Query: 509 ATPSG---GD--APTPGVPTGSPSPDLAPAAEPAPGA------APPPPPPLPGLPSPQEA 557
TP GD A PG+ S PA P+ APPPPPPLP P P +A
Sbjct: 274 ETPLNSVLGDSSASEPGLQAASQ-----PAETPSQQGIVLGPLAPPPPPPLP--PGPAQA 326
Query: 558 PPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPP 612
+ PP P PPP PPLP PPPPPPPPP P VPPPPPPPP PP
Sbjct: 327 SVALPPP-------PGPPPPPPLPSTGPPPPPPPPPLP---NQVPPPPPPPPAPP 371
Score = 64.7 bits (156), Expect = 5e-10
Identities = 71/237 (29%), Positives = 92/237 (38%), Gaps = 35/237 (14%)
Query: 387 LLEDTETKNAVLEHME-ELQEQVALLTERLRDAENESMAKIAELEKQLSQARKELETLRE 445
L E K E +E E E+ L ERL E E + + ++QL + R+E E +E
Sbjct: 147 LQEQQRQKELERERLERERMERERLERERL---ERERLERERLEQEQLERERQERER-QE 202
Query: 446 RFSESTAMGASRRPPEPEKAPPAAPTRPSA--LELKVEELEEKGLIRILRGPGDAVSIEI 503
R + R E+ R LE E +E+ L E
Sbjct: 203 RLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERER 262
Query: 504 LPVAVATPSGGDAPTPGV--PTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAP--P 559
+ A P+ + P V + + P L A++PA PS Q P
Sbjct: 263 RISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAE------------TPSQQGIVLGP 310
Query: 560 SAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGPP 616
APP PPLP P LPPPP PPPPPP +P PPPPPPP PP
Sbjct: 311 LAPPPPPPLPPGPAQASVA-----LPPPPGPPPPPP-----LPSTGPPPPPPP--PP 355
>gi|162329583 cleavage and polyadenylation specific factor 6, 68 kD
subunit [Homo sapiens]
Length = 551
Score = 97.4 bits (241), Expect = 6e-20
Identities = 58/135 (42%), Positives = 62/135 (45%), Gaps = 27/135 (20%)
Query: 511 PSGGDAPTPGVPTGS--PSPDLAPAAEPAPGAAPPP----PPPLPGLPSPQEAPP----- 559
P+G P P P G P P L P P P PPP PPPL G P+ + PP
Sbjct: 220 PAGPGGPPPPFPAGQTPPRPPLGPPGPPGPPGPPPPGQVLPPPLAGPPNRGDRPPPPVLF 279
Query: 560 -----SAPPQAPPLPGSPEP------PPAPPLPGDLPPPPPP--PPPPPGTDGP---VPP 603
PP P PG P P PP PP P PPPPP PP PPG GP + P
Sbjct: 280 PGQPFGQPPLGPLPPGPPPPVPGYGPPPGPPPPQQGPPPPPGPFPPRPPGPLGPPLTLAP 339
Query: 604 PPPPPPPPPGGPPDA 618
PP P PPPG PP A
Sbjct: 340 PPHLPGPPPGAPPPA 354
Score = 90.9 bits (224), Expect = 6e-18
Identities = 61/137 (44%), Positives = 63/137 (45%), Gaps = 16/137 (11%)
Query: 509 ATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQA-PP 567
A P G P P P G P P A P P PP PP PG P P + P PP A PP
Sbjct: 210 AVPGGDRFPGPAGPGGPPPPFPAGQTPPRPPLGPPGPPGPPGPPPPGQVLP--PPLAGPP 267
Query: 568 LPGSPEPPPA--PPLPGDLPP----PPPPPPPPPGTDGPVPPPPPP---PPPPPGGPPDA 618
G PPP P P PP PP PPPP PG GP P PPPP PPPPPG P
Sbjct: 268 NRGDRPPPPVLFPGQPFGQPPLGPLPPGPPPPVPGY-GPPPGPPPPQQGPPPPPGPFPP- 325
Query: 619 LGRRDSELGPGVKAKKP 635
R LGP + P
Sbjct: 326 --RPPGPLGPPLTLAPP 340
Score = 82.4 bits (202), Expect = 2e-15
Identities = 67/186 (36%), Positives = 74/186 (39%), Gaps = 53/186 (28%)
Query: 455 ASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVA-TPSG 513
A + PP P PP P P PG ++LP +A P+
Sbjct: 232 AGQTPPRPPLGPPGPPGPPGPPP-----------------PG-----QVLPPPLAGPPNR 269
Query: 514 GDAPTPGVPTGSPSPDLAPAAEPAPGAAPP-PPPPLPGLPSPQEAPPSAPPQAPPLPGSP 572
GD P P P P P +P G PP PPPP+PG P PP P Q PP P P
Sbjct: 270 GDRPPP--PVLFPGQ---PFGQPPLGPLPPGPPPPVPGYGPPPGPPP--PQQGPPPPPGP 322
Query: 573 EPPPAP-PL--PGDLPPPPPPPPPPPGTDGPVP-------PPP------------PPPPP 610
PP P PL P L PPP P PPPG P P PPP PPP
Sbjct: 323 FPPRPPGPLGPPLTLAPPPHLPGPPPGAPPPAPHVNPAFFPPPTNSGMPTSDSRGPPPTD 382
Query: 611 PPGGPP 616
P G PP
Sbjct: 383 PYGRPP 388
>gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]
Length = 538
Score = 94.4 bits (233), Expect = 5e-19
Identities = 73/222 (32%), Positives = 90/222 (40%), Gaps = 36/222 (16%)
Query: 406 EQVALLTERLRDAENESMAKIAELEKQLSQARKELETLRERFSESTAMGASRRPPEPEKA 465
E++ + R E E AELEK + Q + + + + S S A +PP
Sbjct: 52 ERICRMVRRRHGPEPERTR--AELEKLIQQ--RAVLRVSYKGSISYRNAARVQPPRRGAT 107
Query: 466 PPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGS 525
PPA P P RG A + A A P P P P +
Sbjct: 108 PPAPPRAP-------------------RGAPAAAA------AAAPPPTPAPPPPPAPVAA 142
Query: 526 PSPDLAPAAEPAPGAAPPPPPPL-PGLPSPQEAPPSAPPQAPPLPGSPEPP------PAP 578
+P AP A A APP P P PG + + AP +APP AP P + PP P P
Sbjct: 143 AAPARAPRAAAAAATAPPSPGPAQPGPRAQRAAPLAAPPPAPAAPPAVAPPAGPRRAPPP 202
Query: 579 PLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGPPDALG 620
+ PP PPPP PP PPPP P PPP GG A G
Sbjct: 203 AVAAREPPLPPPPQPPAPPQQQQPPPPQPQPPPEGGAVRAGG 244
Score = 72.4 bits (176), Expect = 2e-12
Identities = 65/208 (31%), Positives = 86/208 (41%), Gaps = 36/208 (17%)
Query: 435 QARKELETLRERFSESTAMGASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRI-LR 493
+AR +LE + M R PEPE+ TR +L ++++ ++R+ +
Sbjct: 46 KARPDLERI-------CRMVRRRHGPEPER------TRAELEKL----IQQRAVLRVSYK 88
Query: 494 GPGDAVSIEILPVAVATPSGGDAPTPGVPTGSP--SPDLAPAAEPAPGAAPPPPPPLPGL 551
G SI A P A TP P +P +P A AA P P APPPPP
Sbjct: 89 G-----SISYRNAARVQPPRRGA-TPPAPPRAPRGAPAAAAAAAPPPTPAPPPPPAPVAA 142
Query: 552 PSPQEAP--PSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPP 609
+P AP +A APP PG +P P L PPP P PP PP
Sbjct: 143 AAPARAPRAAAAAATAPPSPGPAQPGPRAQRAAPLAAPPPAPAAPPAV--------APPA 194
Query: 610 PPPGGPPDALGRRDSELGPGVKAKKPIQ 637
P PP A+ R+ L P + P Q
Sbjct: 195 GPRRAPPPAVAAREPPLPPPPQPPAPPQ 222
Score = 37.0 bits (84), Expect = 0.10
Identities = 38/131 (29%), Positives = 43/131 (32%), Gaps = 16/131 (12%)
Query: 452 AMGASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDA------------- 498
A A+ PP P PP AP +A GP
Sbjct: 121 AAAAAAPPPTPAPPPPPAPVAAAAPARAPRAAAAAATAPPSPGPAQPGPRAQRAAPLAAP 180
Query: 499 VSIEILPVAVATPSGGD-APTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEA 557
P AVA P+G AP P V P P P PAP PPPP P P P+
Sbjct: 181 PPAPAAPPAVAPPAGPRRAPPPAVAAREP-PLPPPPQPPAPPQQQQPPPPQP-QPPPEGG 238
Query: 558 PPSAPPQAPPL 568
A A P+
Sbjct: 239 AVRAGGAARPV 249
Score = 32.3 bits (72), Expect = 2.5
Identities = 48/180 (26%), Positives = 58/180 (32%), Gaps = 24/180 (13%)
Query: 449 ESTAMGASRRP--PEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPV 506
E T +GA P P +APPAA RPS + EE R+L + E
Sbjct: 288 ERTRLGALALPRGDRPGRAPPAASARPSRSKRGGEE-------RVLEKEEEEDDDEDEDE 340
Query: 507 AVATPSGGDAPTPGVPTGSPSPDL------APAAEPAPGAAPPPP--------PPLPGLP 552
G + P P G+ L A E P P P PG
Sbjct: 341 EDDVSEGSEVPESDRPAGAQHHQLNGERGPQSAKERVKEWTPCGPHQGQDEGRGPAPGSG 400
Query: 553 SPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPP 612
+ Q +A + S P P P LPP P P GT PP P P
Sbjct: 401 TRQVFSMAAMNKEGG-TASVATGPDSPSPVPLPPGKPALPGADGTPFGCPPGRKEKPSDP 459
Score = 32.3 bits (72), Expect = 2.5
Identities = 37/148 (25%), Positives = 51/148 (34%), Gaps = 18/148 (12%)
Query: 429 LEKQLSQARKELETLRERFSESTAMGASRRPPEPEKAPPAAPTRPSALELKVEELEEKGL 488
LEK+ + E E + SE + + S RP + P + + +V+E G
Sbjct: 326 LEKEEEEDDDEDEDEEDDVSEGSEVPESDRPAGAQHHQLNGERGPQSAKERVKEWTPCGP 385
Query: 489 IRIL---RGPGDAVSI-EILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPP 544
+ RGP ++ +A GG T V TG SP P
Sbjct: 386 HQGQDEGRGPAPGSGTRQVFSMAAMNKEGG---TASVATGPDSPSPVPL----------- 431
Query: 545 PPPLPGLPSPQEAPPSAPPQAPPLPGSP 572
PP P LP P PP P P
Sbjct: 432 PPGKPALPGADGTPFGCPPGRKEKPSDP 459
Score = 30.8 bits (68), Expect = 7.4
Identities = 15/31 (48%), Positives = 15/31 (48%)
Query: 12 AGPAAPPPKQPAPPKQPMPAAGELEERFNRA 42
A AA PP PAPP P P A R RA
Sbjct: 121 AAAAAAPPPTPAPPPPPAPVAAAAPARAPRA 151
>gi|210032580 SET domain containing 1B [Homo sapiens]
Length = 1923
Score = 90.1 bits (222), Expect = 1e-17
Identities = 69/183 (37%), Positives = 83/183 (45%), Gaps = 32/183 (17%)
Query: 449 ESTAMGASRRPPEPEKAPP-----AAPTRPSALEL---------KVEELEEKGLIRILRG 494
E +G RPP PE PP + T AL+L K++E ++ G
Sbjct: 584 EELDLGLGPRPP-PEPGPPDPAGLLSQTAEVALDLVGDRTPTSEKMDEGQQSS------G 636
Query: 495 PGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSP 554
+S + +P A T + D P P V T + AP+ AP PPPP P LP P
Sbjct: 637 EDMEISDDEMPSAPITSA--DCPKPMVVTPGAAAVAAPSVL-APTLPLPPPPGFPPLPPP 693
Query: 555 QEAPPSAP--PQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPP 612
PP P P PPLP P PPP PP + PPPP P PPG VPPPP PP PP
Sbjct: 694 PPPPPPQPGFPMPPPLP--PPPPPPPPAHPAVTVPPPPLPAPPG----VPPPPILPPLPP 747
Query: 613 GGP 615
P
Sbjct: 748 FPP 750
Score = 64.3 bits (155), Expect = 6e-10
Identities = 66/251 (26%), Positives = 97/251 (38%), Gaps = 44/251 (17%)
Query: 413 ERLRDAENESMAKIAELEKQLSQARKELETLRERFSESTAMGASRRPPEPEKAPPAAPTR 472
E D E+ ++++ +E ++ S + + + + +E+T+ S E E + ++P+
Sbjct: 1073 ESENDDEDTALSEASEKDEGDSDEEETVSIVTSK-AEATSSSESSESSEFESSSESSPSS 1131
Query: 473 PSALELKV-----EELEEKGLIR----ILRGPGD----AVSIEILPVAVATPSGGDAPTP 519
E V EE EE+ ++ GP D + P A A S G
Sbjct: 1132 SEDEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEV 1191
Query: 520 GVPTGSPSPDLAPAA-----------EPAPGAAPPPPP-----------PLPGLPSPQEA 557
+ T + +P+ P+ EPA PP P P P +
Sbjct: 1192 DIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKEVEAR 1251
Query: 558 PPSAPPQAPP--LPGSPEPPPA------PPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPP 609
PP +P +AP L PEPP PPLP PP PP PPP P T P PP P
Sbjct: 1252 PPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPPPEPETTDASHPSVPPEP 1311
Query: 610 PPPGGPPDALG 620
PP G
Sbjct: 1312 LAEDHPPHTPG 1322
Score = 62.8 bits (151), Expect = 2e-09
Identities = 60/234 (25%), Positives = 84/234 (35%), Gaps = 81/234 (34%)
Query: 460 PEPEKAP--------PAAPTRP-SALELKVEEL--EEKGLIRILRGPGDAVSIEILPVAV 508
PEP +P PA P +P +L+ ++E L E++ + LR P +++ +
Sbjct: 474 PEPCDSPGTPTLESSPAGPEKPHDSLDSRIEMLLKEQRTKLLFLREPDSDTELQMEGSPI 533
Query: 509 ATPSGGDAPTPGVPTGS------PSPDLAPAAEPAP-GAAPPPPPPLPGLPSPQEAPPSA 561
++ S +P T S P+P P++ P+ G P PLP +E
Sbjct: 534 SSSSSQLSPLAPFGTNSQPGFRGPTP---PSSRPSSTGLEDISPTPLPDSDEDEELDLGL 590
Query: 562 PPQAPPLPGSPEP-------------------------------------------PPAP 578
P+ PP PG P+P P AP
Sbjct: 591 GPRPPPEPGPPDPAGLLSQTAEVALDLVGDRTPTSEKMDEGQQSSGEDMEISDDEMPSAP 650
Query: 579 PLPGDLPPP-----------------PPPPPPPPGTDGPVPPPPPPPPPPPGGP 615
D P P P P PPP P+PPPPPPPPP PG P
Sbjct: 651 ITSADCPKPMVVTPGAAAVAAPSVLAPTLPLPPPPGFPPLPPPPPPPPPQPGFP 704
Score = 60.8 bits (146), Expect = 7e-09
Identities = 46/142 (32%), Positives = 50/142 (35%), Gaps = 9/142 (6%)
Query: 494 GPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPS 553
GP D + VA GD E + P P P
Sbjct: 599 GPPDPAGLLSQTAEVALDLVGDRTPTSEKMDEGQQSSGEDMEISDDEMPSAPITSADCPK 658
Query: 554 PQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPP-----PGTDGPVPPPPPPP 608
P P A A P +P P PP PG PP PPPPP PG P P PPPPP
Sbjct: 659 PMVVTPGAAAVAAPSVLAPTLPLPPP-PGF---PPLPPPPPPPPPQPGFPMPPPLPPPPP 714
Query: 609 PPPPGGPPDALGRRDSELGPGV 630
PPPP P + PGV
Sbjct: 715 PPPPAHPAVTVPPPPLPAPPGV 736
Score = 59.3 bits (142), Expect = 2e-08
Identities = 76/275 (27%), Positives = 100/275 (36%), Gaps = 53/275 (19%)
Query: 389 EDTETKNAVLEHMEELQEQVALLTERLRDAENESMAKIAELEKQLSQARKELETLRERFS 448
++ ET + V E + + + S + + E+ +++ +E E E +
Sbjct: 1095 DEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREEEEEEEEEEMVA 1154
Query: 449 ESTAMGASRRPPEPEKAPPA-APTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVA 507
E + A E + A AP P+ L +EE V IE VA
Sbjct: 1155 EESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEE---------------EVDIETEAVA 1199
Query: 508 VAT-PSGGDAPTPGVPTGSPSPDLAPAAEPA---PGA---APPPP-------PPLPGLPS 553
PS D P V P+ P EP GA +P PP PPL S
Sbjct: 1200 PEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPL----S 1255
Query: 554 PQEAPPS------APPQAPPLPGSPE-PPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPP 606
P+ AP PP PLP P PPP P P PP PPP P TD P PP
Sbjct: 1256 PERAPEHDLEVEPEPPMMLPLPLQPPLPPPRP------PRPPSPPPEPETTDASHPSVPP 1309
Query: 607 PP-----PPPPGGPPDALGRRDS-ELGPGVKAKKP 635
P PP G +L + S E P +P
Sbjct: 1310 EPLAEDHPPHTPGLCGSLAKSQSTETVPATPGGEP 1344
Score = 57.0 bits (136), Expect = 1e-07
Identities = 46/166 (27%), Positives = 59/166 (35%), Gaps = 48/166 (28%)
Query: 517 PTPGVPTGSPSPDLAPAAEPAPGAAPPP-----PPPLPGLPSPQEAPPSAPPQAPP---- 567
P P +P P P PA A AP P P PL P P + P P ++PP
Sbjct: 1430 PLP-LPLPLPLPLALPAVLRAQARAPTPLPPLLPAPLASCPPPMKRKPGRPRRSPPSMLS 1488
Query: 568 --------------------LPGSPEPPPAPPLP-----------GDLPPPPPPPPPPPG 596
LPG P+ P P +P PPPP PP P
Sbjct: 1489 LDGPLVRPPAGAALGRELLLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQPP 1548
Query: 597 TDGPVPPPPPPPPPPPGGPPDALGRR--DSELGPGVKAKKPIQTKF 640
PPPPPPP P P L + + PG + + + ++
Sbjct: 1549 -----PPPPPPPVEPTKLPFKELDNQWPSEAIPPGPRGRDEVTEEY 1589
Score = 53.9 bits (128), Expect = 8e-07
Identities = 43/143 (30%), Positives = 52/143 (36%), Gaps = 36/143 (25%)
Query: 504 LPVAVATPS----GGDAPTPGVPT-GSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAP 558
LP+ +A P+ APTP P +P P + PG PP + L P P
Sbjct: 1437 LPLPLALPAVLRAQARAPTPLPPLLPAPLASCPPPMKRKPGRPRRSPPSMLSLDGPLVRP 1496
Query: 559 PSAP------------PQAPPLPGSPEP-------------PPAPPLPGDLPPPPPPPPP 593
P+ PQ P P + +P P PPLP PPPPPPPP
Sbjct: 1497 PAGAALGRELLLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQPPPPPPPPPV 1556
Query: 594 PP------GTDGPVPPPPPPPPP 610
P D P PP P
Sbjct: 1557 EPTKLPFKELDNQWPSEAIPPGP 1579
Score = 51.2 bits (121), Expect = 5e-06
Identities = 32/87 (36%), Positives = 35/87 (40%), Gaps = 10/87 (11%)
Query: 503 ILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGL---PSPQEAPP 559
+ P P G P P P P P P P PPPPP P + P P APP
Sbjct: 675 LAPTLPLPPPPGFPPLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPP 734
Query: 560 SAPPQAPPLPGSPEPPPAPPLPGDLPP 586
PP PP+ PP PP P L P
Sbjct: 735 GVPP--PPI-----LPPLPPFPPGLFP 754
Score = 51.2 bits (121), Expect = 5e-06
Identities = 61/228 (26%), Positives = 82/228 (35%), Gaps = 39/228 (17%)
Query: 404 LQEQVALLTERLRDAENESMAKIAELEKQLSQARKELETLRER-FSESTAMGASRRPP-- 460
++E+V + TE + E SM L + + E E S+ AM S PP
Sbjct: 1187 MEEEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAK 1246
Query: 461 EPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPTPG 520
E E PP +P R +L+VE +LP+ + P P P
Sbjct: 1247 EVEARPPLSPERAPEHDLEVEPEPPM----------------MLPLPLQPPLPPPRP-PR 1289
Query: 521 VPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPL 580
P+ P P+ A+ P+ PP PL ++ PP P L S P
Sbjct: 1290 PPSPPPEPETTDASHPSV-----PPEPLA-----EDHPPHTPGLCGSLAKSQSTETVPAT 1339
Query: 581 PGDLPPPPP-------PPPPPPGTDGPVPPPPPPPPPPPGGPPDALGR 621
PG PP P PG+ P P P P GG P GR
Sbjct: 1340 PGGEPPLSGGSSGLSLSSPQVPGS--PFSYPAPSPSLSSGGLPRTPGR 1385
Score = 51.2 bits (121), Expect = 5e-06
Identities = 44/162 (27%), Positives = 50/162 (30%), Gaps = 72/162 (44%)
Query: 517 PTPGVPTGS--------------------------PSPDLAPAAEPAPGAAPPP-----P 545
P +PTG P P PA A AP P P
Sbjct: 1403 PVCPLPTGRRDERSGPLASPVLLETGLPLPLPLPLPLPLALPAVLRAQARAPTPLPPLLP 1462
Query: 546 PPLPGLPSPQEAPPSAPPQAPP------------------------LPGSPEPPPAPPL- 580
PL P P + P P ++PP LPG P+ P P
Sbjct: 1463 APLASCPPPMKRKPGRPRRSPPSMLSLDGPLVRPPAGAALGRELLLLPGQPQTPVFPSTH 1522
Query: 581 ----------PGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPP 612
+P PPPP PP P PPPPPPPP P
Sbjct: 1523 DPRTVTLDFRNAGIPAPPPPLPPQP------PPPPPPPPVEP 1558
Score = 49.7 bits (117), Expect = 2e-05
Identities = 37/107 (34%), Positives = 43/107 (40%), Gaps = 9/107 (8%)
Query: 516 APTPGVPTGSPSPDLAPAAEP--APGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPE 573
A TP +P+P A P P A PPPP P + A S + P P P
Sbjct: 379 AHTPPPAQATPAPGFKSAFSPYQTPVAHFPPPPEEPTATAAFGARDSGEFRRAPAP--PP 436
Query: 574 PPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPP-----PPPPPPPGGP 615
PPA PL + P PP PPPP + P P P PG P
Sbjct: 437 LPPAEPLAKEKPGTPPGPPPPDTNSMELGGRPTFGWSPEPCDSPGTP 483
Score = 46.6 bits (109), Expect = 1e-04
Identities = 34/110 (30%), Positives = 39/110 (35%)
Query: 513 GGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSP 572
GG + G P + D A A P A P P SP + P + P P P +
Sbjct: 358 GGTGGSSGPPFKAQPQDSATFAHTPPPAQATPAPGFKSAFSPYQTPVAHFPPPPEEPTAT 417
Query: 573 EPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGPPDALGRR 622
A P PPP PP P PP PPPP LG R
Sbjct: 418 AAFGARDSGEFRRAPAPPPLPPAEPLAKEKPGTPPGPPPPDTNSMELGGR 467
Score = 40.8 bits (94), Expect = 0.007
Identities = 51/195 (26%), Positives = 64/195 (32%), Gaps = 43/195 (22%)
Query: 454 GASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSG 513
G RR P P PPA P +EK P D S+E+ P+
Sbjct: 426 GEFRRAPAPPPLPPAEPLA-----------KEKPGTPPGPPPPDTNSMEL----GGRPTF 470
Query: 514 GDAPTPGVPTGSPSPDLAPAAEPAPGAA---------------------PPPPPPL---- 548
G +P P G+P+ + +PA P + P L
Sbjct: 471 GWSPEPCDSPGTPTLESSPAGPEKPHDSLDSRIEMLLKEQRTKLLFLREPDSDTELQMEG 530
Query: 549 -PGLPSPQEAPPSAPPQAPPLPG--SPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPP 605
P S + P AP PG P PP + P L P P P D +
Sbjct: 531 SPISSSSSQLSPLAPFGTNSQPGFRGPTPPSSRPSSTGLEDISPTPLPDSDEDEELDLGL 590
Query: 606 PPPPPPPGGPPDALG 620
P PPP GPPD G
Sbjct: 591 GPRPPPEPGPPDPAG 605
Score = 40.4 bits (93), Expect = 0.009
Identities = 34/108 (31%), Positives = 35/108 (32%), Gaps = 18/108 (16%)
Query: 527 SPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPP 586
S DL A G + PP S A P QA P PG P P
Sbjct: 349 SSDLPFGAVGGTGGSSGPPFKAQPQDSATFAHTPPPAQATPAPGFKSAFSPYQTPVAHFP 408
Query: 587 PPPPPPPPPGTDG----------PVPPPPPPPPP--------PPGGPP 616
PPP P G P PPP PP P PPG PP
Sbjct: 409 PPPEEPTATAAFGARDSGEFRRAPAPPPLPPAEPLAKEKPGTPPGPPP 456
Score = 39.7 bits (91), Expect = 0.016
Identities = 34/114 (29%), Positives = 40/114 (35%), Gaps = 14/114 (12%)
Query: 510 TPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLP 569
TP P P PT + + + E APPP PP A P A P
Sbjct: 402 TPVAHFPPPPEEPTATAAFGARDSGEFRRAPAPPPLPP-------------AEPLAKEKP 448
Query: 570 GSPEPPPAPPLPG-DLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGPPDALGRR 622
G+P PP P +L P P D P P P P P D+L R
Sbjct: 449 GTPPGPPPPDTNSMELGGRPTFGWSPEPCDSPGTPTLESSPAGPEKPHDSLDSR 502
Score = 39.3 bits (90), Expect = 0.021
Identities = 64/260 (24%), Positives = 73/260 (28%), Gaps = 102/260 (39%)
Query: 459 PPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDA-- 516
PPEPE + P+ P + GL L ++ P SGG +
Sbjct: 1294 PPEPETTDASHPSVPPEPLAEDHPPHTPGLCGSLAKSQSTETVPATPGGEPPLSGGSSGL 1353
Query: 517 -----PTPGVPTG--SPSPDLAPAAEP---------APGAAPPPPP------PLP----- 549
PG P +PSP L+ P P + P P PLP
Sbjct: 1354 SLSSPQVPGSPFSYPAPSPSLSSGGLPRTPGRDFSFTPTFSEPSGPLLLPVCPLPTGRRD 1413
Query: 550 --------------GLPSPQEAP--------------PSAPPQAPPL------------- 568
GLP P P AP PPL
Sbjct: 1414 ERSGPLASPVLLETGLPLPLPLPLPLPLALPAVLRAQARAPTPLPPLLPAPLASCPPPMK 1473
Query: 569 --PGSP--EPPPAPPLPGDLPPPP---------------PPPPPPPGTDG---------- 599
PG P PP L G L PP P P P T
Sbjct: 1474 RKPGRPRRSPPSMLSLDGPLVRPPAGAALGRELLLLPGQPQTPVFPSTHDPRTVTLDFRN 1533
Query: 600 ---PVPPPPPPPPPPPGGPP 616
P PPPP PP PPP PP
Sbjct: 1534 AGIPAPPPPLPPQPPPPPPP 1553
>gi|4826998 splicing factor proline/glutamine rich (polypyrimidine
tract binding protein associated) [Homo sapiens]
Length = 707
Score = 87.4 bits (215), Expect = 7e-17
Identities = 75/243 (30%), Positives = 99/243 (40%), Gaps = 42/243 (17%)
Query: 460 PEPEKAPPAAPT---RPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDA 516
P P++ PP P +P + ++ + +GPG A + P A ++
Sbjct: 77 PPPQQPPPHQPPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATP 136
Query: 517 PTPGVPTGS---PSPDLAPAAEPAPGAAPPPPPPLPGLPS--PQEAPPSAPPQAPPLPG- 570
PT G P GS P+P PA AP APPP PP G+P+ PQ P PP A P PG
Sbjct: 137 PTSGAPPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGVPTTPPQAGGPPPPPAAVPGPGP 196
Query: 571 SPEPPPAPPLP-GDLPPPPPPPPPPPGTDGPVPPPPPP--------------PP------ 609
P+ P P P G P P P PG P P PP PP
Sbjct: 197 GPKQGPGPGGPKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGGEPRGGRQHHPPYHQQHH 256
Query: 610 --PPPGGPPDALGRRDSEL--GPGVKA-----KKPIQTKFRMPLLNWVALKPSQITGTVF 660
PPPGGP GR + ++ G KA ++P + + +V P+ IT F
Sbjct: 257 QGPPPGGPG---GRSEEKISDSEGFKANLSLLRRPGEKTYTQRCRLFVGNLPADITEDEF 313
Query: 661 TEL 663
L
Sbjct: 314 KRL 316
Score = 73.2 bits (178), Expect = 1e-12
Identities = 49/144 (34%), Positives = 54/144 (37%), Gaps = 32/144 (22%)
Query: 517 PTPGVPTGSPSPDLAPAAEPAPGAAPP---------PPP---------------PLPGLP 552
P P P P P +P P PP PPP P PG+
Sbjct: 63 PPPHQQQQQPPPQQPPPQQPPPHQPPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVG 122
Query: 553 SPQEAPPSAPPQAPPLPGSPE-----PPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPP- 606
S A SAPP PP G+P P P PP PP PPP PP + P PP
Sbjct: 123 SAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGVPTTPPQAG 182
Query: 607 -PPPPPPGGPPDALGRRDSELGPG 629
PPPPP P G + GPG
Sbjct: 183 GPPPPPAAVPGPGPGPKQGP-GPG 205
Score = 68.6 bits (166), Expect = 3e-11
Identities = 41/115 (35%), Positives = 46/115 (40%), Gaps = 11/115 (9%)
Query: 513 GGDAPTPGVPTGSP--SPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQA--PPL 568
G P P +P P P +P P PP PP P Q+ PP P + P +
Sbjct: 52 GQSGPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQPPPHPQPHQQQQPPPPPQDSSKPVV 111
Query: 569 PGSPEPPP----APPLPGDLPPPPPPPPPPPGTDGPVPPPPPPP---PPPPGGPP 616
P P P APP PP PP P GP P P PPP PPG PP
Sbjct: 112 AQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPGAPP 166
Score = 67.8 bits (164), Expect = 5e-11
Identities = 51/147 (34%), Positives = 54/147 (36%), Gaps = 33/147 (22%)
Query: 494 GPGDAVSIEILPVAVATP-SGGDAPTPGVPTGSPSPDLAPAAEPAPGAA--PPPPP---- 546
GPG S P+ P P P P P P P P PPPPP
Sbjct: 48 GPGPGQSGPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQPPPHPQPHQQQQPPPPPQDSS 107
Query: 547 ---------PLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGT 597
P PG+ S A SAPP PP G+P PG P P P PPP T
Sbjct: 108 KPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAP--------PGS-GPGPTPTPPPAVT 158
Query: 598 DGPVPPPPPPP--------PPPPGGPP 616
P PPP P PP GGPP
Sbjct: 159 SAPPGAPPPTPPSSGVPTTPPQAGGPP 185
Score = 65.1 bits (157), Expect = 4e-10
Identities = 46/153 (30%), Positives = 53/153 (34%), Gaps = 13/153 (8%)
Query: 516 APTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPP 575
+P PG+ + P + G PP PPP P Q P PPQ PP P P P
Sbjct: 33 SPPPGMGLNQNRGPMGPGPGQS-GPKPPIPPPPPHQQQQQPPPQQPPPQQPP-PHQPPPH 90
Query: 576 PAPPLPGDLPPPP-----------PPPPPPPGTDGPVPPPPPPPPPPPGGPPDALGRRDS 624
P P PPPP P P P G+ P PP PP G P G +
Sbjct: 91 PQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPT 150
Query: 625 ELGPGVKAKKPIQTKFRMPLLNWVALKPSQITG 657
P P P + V P Q G
Sbjct: 151 PTPPPAVTSAPPGAPPPTPPSSGVPTTPPQAGG 183
>gi|150417989 cyclin K isoform 1 [Homo sapiens]
Length = 580
Score = 87.0 bits (214), Expect = 9e-17
Identities = 65/171 (38%), Positives = 74/171 (43%), Gaps = 17/171 (9%)
Query: 459 PPEPEKAPPAAP----TRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGG 514
PP P + PP P T S + + L +++ G S LP A P
Sbjct: 414 PPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGP--SYGALPPAYGPP--- 468
Query: 515 DAPTPGVPTGSPSPDLAPAAEPAPGAAPPP--PPPLPGLPSPQEA-PPSAPPQAPPLPGS 571
A P P P P P P + PPP PPP PG P P P+ PP P LP +
Sbjct: 469 -AHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPT 527
Query: 572 PEPPPAPPLPGDLPPPP-PPPPPPPGTDGPVPPPPPPPPPPPGGPPDALGR 621
PP PP LPP PPP PPG PVPPP PPP PP G LGR
Sbjct: 528 HAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVG---GLGR 575
Score = 76.6 bits (187), Expect = 1e-13
Identities = 55/164 (33%), Positives = 60/164 (36%), Gaps = 48/164 (29%)
Query: 505 PVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPP----PPPLP----------- 549
P A + P P T P + P A PAP PPP PPP P
Sbjct: 376 PPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTT 435
Query: 550 -----------------------GLPSPQEAPPSAPPQAPPL-PGSPEPPPAPPLPGDLP 585
G P PP+ P P + P +P PPP PP P P
Sbjct: 436 SSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFP 495
Query: 586 PPPPPP-----PPPPGTDGPVPPPPPPPPPP----PGGPPDALG 620
PP PP PPPP T P PPPPP PP P PP LG
Sbjct: 496 PPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLG 539
Score = 65.5 bits (158), Expect = 3e-10
Identities = 49/150 (32%), Positives = 52/150 (34%), Gaps = 56/150 (37%)
Query: 526 PSPDLAPAAE----PAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLP 581
P P P E P P A PPP P + EA P P A LP PPPA P P
Sbjct: 350 PPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAP 409
Query: 582 GDLPPPPP--PPPPPPG--------------------------TDGPV------------ 601
PPP P PPPPPP T+GP
Sbjct: 410 VHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPA 469
Query: 602 ------------PPPPPPPPPPPGGPPDAL 619
PPPPP PPPP PP A+
Sbjct: 470 HLPYHPHVYPPNPPPPPVPPPPASFPPPAI 499
Score = 55.8 bits (133), Expect = 2e-07
Identities = 35/82 (42%), Positives = 41/82 (50%), Gaps = 12/82 (14%)
Query: 540 AAPPPPPPLPGLPSPQEA-PPSAPP--QAPPLPGS--PEPPPAPPLPGDLPPPPPPPPPP 594
AA PPPP +P + + PP+ PP + PPL + PP P DLP PPP
Sbjct: 347 AAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAH 406
Query: 595 PGTDGPVPPPPP----PPPPPP 612
P PV PPP PPPPPP
Sbjct: 407 PA---PVHQPPPLPHRPPPPPP 425
Score = 52.8 bits (125), Expect = 2e-06
Identities = 44/145 (30%), Positives = 53/145 (36%), Gaps = 50/145 (34%)
Query: 522 PTGSPSPDLAPAAEPAPGAAPPPPPPL---PGLPSPQEAPPSAPPQAPPLPGSP------ 572
P+ P+P + + P + P P P P+ Q+ P P + P P SP
Sbjct: 277 PSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRA 336
Query: 573 ------------EPPPA---------PPLPGDLPPP---PP---------PPPPPPGTDG 599
EPPP PPLP PPP PP PP P TD
Sbjct: 337 VVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDL 396
Query: 600 P---VPPPPPP-----PPPPPGGPP 616
P +PPP P PPP P PP
Sbjct: 397 PKVQIPPPAHPAPVHQPPPLPHRPP 421
Score = 44.7 bits (104), Expect = 5e-04
Identities = 32/111 (28%), Positives = 38/111 (34%), Gaps = 27/111 (24%)
Query: 542 PPPPPPLPGLPSPQEAPPS----------APPQAPPLPGSPEPPPAPPLPGDLPP----- 586
PP P P +P Q++ PS PQ P P P P P P
Sbjct: 276 PPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKR 335
Query: 587 ------------PPPPPPPPPGTDGPVPPPPPPPPPPPGGPPDALGRRDSE 625
PPPP P + PP PP PPP PP A ++E
Sbjct: 336 AVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAE 386
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,758,458
Number of Sequences: 37866
Number of extensions: 4022939
Number of successful extensions: 179527
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 2011
Number of HSP's successfully gapped in prelim test: 1888
Number of HSP's that attempted gapping in prelim test: 30288
Number of HSP's gapped (non-prelim): 49283
length of query: 1100
length of database: 18,247,518
effective HSP length: 113
effective length of query: 987
effective length of database: 13,968,660
effective search space: 13787067420
effective search space used: 13787067420
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.