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Search of human proteins with 31542504
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
(735 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 1517 0.0
gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 1517 0.0
gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 1517 0.0
gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 1517 0.0
gi|22027632 diacylglycerol kinase, beta isoform 1 [Homo sapiens] 885 0.0
gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo sapiens] 850 0.0
gi|124256476 diacylglycerol kinase gamma isoform 1 [Homo sapiens] 786 0.0
gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo sapiens] 742 0.0
gi|124256482 diacylglycerol kinase gamma isoform 3 [Homo sapiens] 724 0.0
gi|4758156 diacylglycerol kinase, iota [Homo sapiens] 286 4e-77
gi|41872507 diacylglycerol kinase zeta isoform 2 [Homo sapiens] 279 6e-75
gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens] 279 6e-75
gi|157688564 diacylglycerol kinase zeta isoform 4 [Homo sapiens] 279 8e-75
gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens] 279 8e-75
gi|4503313 diacylglycerol kinase epsilon [Homo sapiens] 276 5e-74
gi|40806175 diacylglycerol kinase, theta [Homo sapiens] 228 2e-59
gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo ... 206 8e-53
gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo ... 206 8e-53
gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens] 205 1e-52
gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens] 205 1e-52
gi|62000702 diacylglycerol kinase kappa [Homo sapiens] 191 2e-48
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom... 57 5e-08
gi|13384594 protein kinase C, gamma [Homo sapiens] 52 2e-06
gi|47157325 protein kinase C, delta [Homo sapiens] 48 3e-05
gi|31377782 protein kinase C, delta [Homo sapiens] 48 3e-05
gi|28557781 protein kinase C, eta [Homo sapiens] 48 4e-05
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 47 5e-05
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 47 5e-05
gi|5453976 protein kinase C, theta [Homo sapiens] 47 5e-05
gi|4506067 protein kinase C, alpha [Homo sapiens] 46 1e-04
>gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 1517 bits (3928), Expect = 0.0
Identities = 735/735 (100%), Positives = 735/735 (100%)
Query: 1 MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIY 60
MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIY
Sbjct: 1 MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIY 60
Query: 61 LEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK 120
LEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK
Sbjct: 61 LEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK 120
Query: 121 LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEW 180
LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEW
Sbjct: 121 LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEW 180
Query: 181 VRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY 240
VRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY
Sbjct: 181 VRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY 240
Query: 241 TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC 300
TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC
Sbjct: 241 TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC 300
Query: 301 VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL 360
VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL
Sbjct: 301 VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL 360
Query: 361 STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL 420
STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL
Sbjct: 361 STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL 420
Query: 421 FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ 480
FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ
Sbjct: 421 FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ 480
Query: 481 NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIM 540
NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIM
Sbjct: 481 NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIM 540
Query: 541 REKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL 600
REKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL
Sbjct: 541 REKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL 600
Query: 601 NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE 660
NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE
Sbjct: 601 NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE 660
Query: 661 GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML 720
GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML
Sbjct: 661 GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML 720
Query: 721 MGPPPRSTNFFGFLS 735
MGPPPRSTNFFGFLS
Sbjct: 721 MGPPPRSTNFFGFLS 735
>gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 1517 bits (3928), Expect = 0.0
Identities = 735/735 (100%), Positives = 735/735 (100%)
Query: 1 MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIY 60
MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIY
Sbjct: 1 MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIY 60
Query: 61 LEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK 120
LEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK
Sbjct: 61 LEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK 120
Query: 121 LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEW 180
LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEW
Sbjct: 121 LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEW 180
Query: 181 VRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY 240
VRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY
Sbjct: 181 VRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY 240
Query: 241 TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC 300
TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC
Sbjct: 241 TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC 300
Query: 301 VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL 360
VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL
Sbjct: 301 VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL 360
Query: 361 STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL 420
STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL
Sbjct: 361 STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL 420
Query: 421 FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ 480
FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ
Sbjct: 421 FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ 480
Query: 481 NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIM 540
NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIM
Sbjct: 481 NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIM 540
Query: 541 REKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL 600
REKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL
Sbjct: 541 REKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL 600
Query: 601 NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE 660
NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE
Sbjct: 601 NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE 660
Query: 661 GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML 720
GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML
Sbjct: 661 GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML 720
Query: 721 MGPPPRSTNFFGFLS 735
MGPPPRSTNFFGFLS
Sbjct: 721 MGPPPRSTNFFGFLS 735
>gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 1517 bits (3928), Expect = 0.0
Identities = 735/735 (100%), Positives = 735/735 (100%)
Query: 1 MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIY 60
MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIY
Sbjct: 1 MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIY 60
Query: 61 LEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK 120
LEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK
Sbjct: 61 LEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK 120
Query: 121 LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEW 180
LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEW
Sbjct: 121 LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEW 180
Query: 181 VRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY 240
VRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY
Sbjct: 181 VRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY 240
Query: 241 TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC 300
TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC
Sbjct: 241 TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC 300
Query: 301 VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL 360
VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL
Sbjct: 301 VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL 360
Query: 361 STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL 420
STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL
Sbjct: 361 STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL 420
Query: 421 FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ 480
FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ
Sbjct: 421 FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ 480
Query: 481 NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIM 540
NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIM
Sbjct: 481 NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIM 540
Query: 541 REKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL 600
REKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL
Sbjct: 541 REKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL 600
Query: 601 NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE 660
NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE
Sbjct: 601 NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE 660
Query: 661 GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML 720
GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML
Sbjct: 661 GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML 720
Query: 721 MGPPPRSTNFFGFLS 735
MGPPPRSTNFFGFLS
Sbjct: 721 MGPPPRSTNFFGFLS 735
>gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 1517 bits (3928), Expect = 0.0
Identities = 735/735 (100%), Positives = 735/735 (100%)
Query: 1 MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIY 60
MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIY
Sbjct: 1 MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIY 60
Query: 61 LEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK 120
LEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK
Sbjct: 61 LEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK 120
Query: 121 LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEW 180
LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEW
Sbjct: 121 LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEW 180
Query: 181 VRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY 240
VRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY
Sbjct: 181 VRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY 240
Query: 241 TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC 300
TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC
Sbjct: 241 TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC 300
Query: 301 VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL 360
VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL
Sbjct: 301 VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL 360
Query: 361 STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL 420
STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL
Sbjct: 361 STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL 420
Query: 421 FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ 480
FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ
Sbjct: 421 FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ 480
Query: 481 NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIM 540
NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIM
Sbjct: 481 NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIM 540
Query: 541 REKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL 600
REKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL
Sbjct: 541 REKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL 600
Query: 601 NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE 660
NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE
Sbjct: 601 NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE 660
Query: 661 GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML 720
GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML
Sbjct: 661 GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML 720
Query: 721 MGPPPRSTNFFGFLS 735
MGPPPRSTNFFGFLS
Sbjct: 721 MGPPPRSTNFFGFLS 735
>gi|22027632 diacylglycerol kinase, beta isoform 1 [Homo sapiens]
Length = 804
Score = 885 bits (2287), Expect = 0.0
Identities = 446/788 (56%), Positives = 554/788 (70%), Gaps = 71/788 (9%)
Query: 8 ISPSDFAQLQKYMEYSTKKVSDVLKLFE-DGEMAKY-------VQGDAIGYEGFQQFLKI 59
+SPS+F+QLQKY EYSTKK+ DVL+ F +G +AKY + I +EGF+ F+K
Sbjct: 10 LSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGFKLFMKT 69
Query: 60 YLEVDNVPRHLSLALFQSFET------------------GHCLNETNVTK---------- 91
+LE + +P + LF SF G +N+ +T
Sbjct: 70 FLEAE-LPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTSPANTC 128
Query: 92 --DVVCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYL 149
+V+ L D+ CY SLLE GRPEDKLEF F+LYDTD NG LDSSE++ II QMM VAEYL
Sbjct: 129 SPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYL 188
Query: 150 DWDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTVPLLVLLGLEMTLKDDGQHMWR 209
+WDV+EL PIL EMM+EIDYD G+VS EW++ G TT+PLLVLLGLE +KDDGQH+WR
Sbjct: 189 EWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWR 248
Query: 210 PKRFPRPVYCNLCESS-IGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQ 268
K F +P YCNLC + IG+GKQGL C+ CKYTVH++C +A P + TY KS+++ V
Sbjct: 249 LKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVM 308
Query: 269 SHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHI 328
H WV G C + +CD+C K ++ Y LTGLHCVWC + +H+ C + ECDCG L+DHI
Sbjct: 309 HHYWVEGNCPT-KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHI 367
Query: 329 LPPSSIYPSVLASGP----------------DRKNSKTSQKTMDDLNLSTSEALRID--- 369
LPP++I P VL + P ++ S+ K +D + + ++ +D
Sbjct: 368 LPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQG 427
Query: 370 ----PVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVP 425
PVP THPLLVFVNPKSGGKQG+R+ KFQY+LNPRQV++L +GP GL F+DVP
Sbjct: 428 LQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVP 487
Query: 426 DSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKI 485
D R+L CGGDGTVGW+L+ I+KAN+ PPVA+LPLGTGNDLARCLRWGGGYEG+NL KI
Sbjct: 488 DFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKI 547
Query: 486 LKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYP 545
LKD+E S + +DRW EVIP +EK DPVP+ IINNYFSIGVDASIAHRFHIMREK+P
Sbjct: 548 LKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHP 607
Query: 546 EKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSM 605
EKFNSRMKNK WYFEF TSE+ +TCKKL ES+ +E G +DL N+SLEGIA+LNIPSM
Sbjct: 608 EKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSM 667
Query: 606 HGGSNLWGDT--RRPHGDIYGINQALGATAK-VITDPDILKTCVPDLSDKRLEVVGLEGA 662
HGGSNLWG++ RR H I + G+ + +TD LK DLSD+ LEVVGLEGA
Sbjct: 668 HGGSNLWGESKKRRSHRRI----EKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGA 723
Query: 663 IEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPMLMG 722
+EMGQIYT LK+AGRRLA+CS + T+K+LPMQIDGEPWMQTPCTIKITHKNQ PMLMG
Sbjct: 724 MEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPMLMG 783
Query: 723 PPPRSTNF 730
PPP++ F
Sbjct: 784 PPPKTGLF 791
>gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo sapiens]
Length = 773
Score = 850 bits (2197), Expect = 0.0
Identities = 429/767 (55%), Positives = 536/767 (69%), Gaps = 71/767 (9%)
Query: 8 ISPSDFAQLQKYMEYSTKKVSDVLKLFE-DGEMAKY-------VQGDAIGYEGFQQFLKI 59
+SPS+F+QLQKY EYSTKK+ DVL+ F +G +AKY + I +EGF+ F+K
Sbjct: 10 LSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGFKLFMKT 69
Query: 60 YLEVDNVPRHLSLALFQSFET------------------GHCLNETNVTK---------- 91
+LE + +P + LF SF G +N+ +T
Sbjct: 70 FLEAE-LPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTSPANTC 128
Query: 92 --DVVCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYL 149
+V+ L D+ CY SLLE GRPEDKLEF F+LYDTD NG LDSSE++ II QMM VAEYL
Sbjct: 129 SPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYL 188
Query: 150 DWDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTVPLLVLLGLEMTLKDDGQHMWR 209
+WDV+EL PIL EMM+EIDYD G+VS EW++ G TT+PLLVLLGLE +KDDGQH+WR
Sbjct: 189 EWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWR 248
Query: 210 PKRFPRPVYCNLCESS-IGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQ 268
K F +P YCNLC + IG+GKQGL C+ CKYTVH++C +A P + TY KS+++ V
Sbjct: 249 LKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVM 308
Query: 269 SHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHI 328
H WV G C + +CD+C K ++ Y LTGLHCVWC + +H+ C + ECDCG L+DHI
Sbjct: 309 HHYWVEGNCPT-KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHI 367
Query: 329 LPPSSIYPSVLASGP----------------DRKNSKTSQKTMDDLNLSTSEALRID--- 369
LPP++I P VL + P ++ S+ K +D + + ++ +D
Sbjct: 368 LPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQG 427
Query: 370 ----PVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVP 425
PVP THPLLVFVNPKSGGKQG+R+ KFQY+LNPRQV++L +GP GL F+DVP
Sbjct: 428 LQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVP 487
Query: 426 DSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKI 485
D R+L CGGDGTVGW+L+ I+KAN+ PPVA+LPLGTGNDLARCLRWGGGYEG+NL KI
Sbjct: 488 DFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKI 547
Query: 486 LKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYP 545
LKD+E S + +DRW EVIP +EK DPVP+ IINNYFSIGVDASIAHRFHIMREK+P
Sbjct: 548 LKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHP 607
Query: 546 EKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSM 605
EKFNSRMKNK WYFEF TSE+ +TCKKL ES+ +E G +DL N+SLEGIA+LNIPSM
Sbjct: 608 EKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSM 667
Query: 606 HGGSNLWGDT--RRPHGDIYGINQALGATAK-VITDPDILKTCVPDLSDKRLEVVGLEGA 662
HGGSNLWG++ RR H I + G+ + +TD LK DLSD+ LEVVGLEGA
Sbjct: 668 HGGSNLWGESKKRRSHRRI----EKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGA 723
Query: 663 IEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTI 709
+EMGQIYT LK+AGRRLA+CS + T+K+LPMQIDGEPWMQTPCT+
Sbjct: 724 MEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTV 770
>gi|124256476 diacylglycerol kinase gamma isoform 1 [Homo sapiens]
Length = 791
Score = 786 bits (2029), Expect = 0.0
Identities = 411/798 (51%), Positives = 519/798 (65%), Gaps = 85/798 (10%)
Query: 1 MAKERGL-ISPSDFAQLQKYMEYSTKKVSDVLKLF-EDGEMAKYVQGDAIGYEGFQQFLK 58
M +ER + ++P +F QLQKY EYS+KK+ D L F E G + +Y + I Y+ F+ F++
Sbjct: 1 MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMR 60
Query: 59 --------------IYLEVDNVPRH---------LSLALFQSFETGHCLNETNVTK---- 91
++L PRH S + S +T + N N TK
Sbjct: 61 AYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADT-NIQNADNATKADEA 119
Query: 92 -------------------------------------DVVCLNDVSCYFSLLEGGRPEDK 114
VV L DV CY SLLE GRP+DK
Sbjct: 120 CAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDK 179
Query: 115 LEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGS 174
LEF F+LYD+D NG+LD +E+D I+ QM+ +A+YL+WD +ELRPIL+EM++ +DYD G
Sbjct: 180 LEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGF 239
Query: 175 VSQAEWVRAGATTVPLLVLLGLEMT-LKDDGQHMWRPKRFPRPVYCNLCESSI-GLGKQG 232
VS EWV G TT+PLLVLLG++ + K DG+H W K F +P YCN C + G+ KQG
Sbjct: 240 VSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQG 299
Query: 233 LSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIY 292
L C CKYTVH++C + +P V TY+K+++ V H WV G S +CDRC K I+ Y
Sbjct: 300 LCCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGN-SSVKCDRCHKSIKCY 358
Query: 293 HSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQ 352
S+T HCVWC + H C + CD G LRDHIL P+SI P ++ + S
Sbjct: 359 QSVTARHCVWCRMTFHRKC--ELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSA 416
Query: 353 KTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKD 412
K +L + +I P P THPLLV VNPKSGG+QG+R+L KF Y+LNP+QVFNL
Sbjct: 417 K--GELVMQ----YKIIPTPGTHPLLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDNG 470
Query: 413 GPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLR 472
GP GL F+D PD R+L CGGDGTVGWIL+ IDKAN PPVAVLPLGTGNDLARCLR
Sbjct: 471 GPTPGLNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLR 530
Query: 473 WGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDAS 532
WGGGYEG +L KILKD+E S +V +DRW +EVIP++ E D VP+ I+NNYFSIGVDAS
Sbjct: 531 WGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDAS 590
Query: 533 IAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNL 592
IAHRFH+MREK+PEKFNSRMKNKLWYFEF TSE+ +TCKKL + + +E G +DLSN+
Sbjct: 591 IAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNI 650
Query: 593 SLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDK 652
LEGIA+LNIPSM+GG+NLWG+ ++ + + K +TDP LK CV DLSD+
Sbjct: 651 FLEGIAILNIPSMYGGTNLWGENKKNRA-------VIRESRKGVTDPKELKFCVQDLSDQ 703
Query: 653 RLEVVGLEGAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKIT 712
LEVVGLEGA+EMGQIYT LK+AGRRLA+C+ +T T K LPMQ+DGEPWMQ CTIKIT
Sbjct: 704 LLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKIT 763
Query: 713 HKNQMPMLMGPPPRSTNF 730
HKNQ PM+MGPP +S+ F
Sbjct: 764 HKNQAPMMMGPPQKSSFF 781
>gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo sapiens]
Length = 766
Score = 742 bits (1915), Expect = 0.0
Identities = 396/798 (49%), Positives = 501/798 (62%), Gaps = 110/798 (13%)
Query: 1 MAKERGL-ISPSDFAQLQKYMEYSTKKVSDVLKLF-EDGEMAKYVQGDAIGYEGFQQFLK 58
M +ER + ++P +F QLQKY EYS+KK+ D L F E G + +Y + I Y+ F+ F++
Sbjct: 1 MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMR 60
Query: 59 --------------IYLEVDNVPRH---------LSLALFQSFETGHCLNETNVTK---- 91
++L PRH S + S +T + N N TK
Sbjct: 61 AYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADT-NIQNADNATKADEA 119
Query: 92 -------------------------------------DVVCLNDVSCYFSLLEGGRPEDK 114
VV L DV CY SLLE GRP+DK
Sbjct: 120 CAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDK 179
Query: 115 LEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGS 174
LEF F+LYD+D NG+LD +E+D I+ QM+ +A+YL+WD +ELRPIL+EM++ +DYD G
Sbjct: 180 LEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGF 239
Query: 175 VSQAEWVRAGATTVPLLVLLGLEMT-LKDDGQHMWRPKRFPRPVYCNLCESSI-GLGKQG 232
VS EWV G TT+PLLVLLG++ + K DG+H W K F +P YCN C + G+ KQG
Sbjct: 240 VSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQG 299
Query: 233 LSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIY 292
L C CKYTVH++C + +P V TY+K+++ V H WV G S +CDRC K I+ Y
Sbjct: 300 LCCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGN-SSVKCDRCHKSIKCY 358
Query: 293 HSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQ 352
S+T HCVWC + H C + CD G LRDHIL P+SI P ++ + S
Sbjct: 359 QSVTARHCVWCRMTFHRKC--ELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSA 416
Query: 353 KTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKD 412
K +L + +I P P THPLLV VNPKSGG+QG+R
Sbjct: 417 K--GELVMQ----YKIIPTPGTHPLLVLVNPKSGGRQGER-------------------- 450
Query: 413 GPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLR 472
L F+D PD R+L CGGDGTVGWIL+ IDKAN PPVAVLPLGTGNDLARCLR
Sbjct: 451 -----LNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLR 505
Query: 473 WGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDAS 532
WGGGYEG +L KILKD+E S +V +DRW +EVIP++ E D VP+ I+NNYFSIGVDAS
Sbjct: 506 WGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDAS 565
Query: 533 IAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNL 592
IAHRFH+MREK+PEKFNSRMKNKLWYFEF TSE+ +TCKKL + + +E G +DLSN+
Sbjct: 566 IAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNI 625
Query: 593 SLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDK 652
LEGIA+LNIPSM+GG+NLWG+ ++ + + K +TDP LK CV DLSD+
Sbjct: 626 FLEGIAILNIPSMYGGTNLWGENKKNRA-------VIRESRKGVTDPKELKFCVQDLSDQ 678
Query: 653 RLEVVGLEGAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKIT 712
LEVVGLEGA+EMGQIYT LK+AGRRLA+C+ +T T K LPMQ+DGEPWMQ CTIKIT
Sbjct: 679 LLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKIT 738
Query: 713 HKNQMPMLMGPPPRSTNF 730
HKNQ PM+MGPP +S+ F
Sbjct: 739 HKNQAPMMMGPPQKSSFF 756
>gi|124256482 diacylglycerol kinase gamma isoform 3 [Homo sapiens]
Length = 752
Score = 724 bits (1868), Expect = 0.0
Identities = 394/798 (49%), Positives = 498/798 (62%), Gaps = 124/798 (15%)
Query: 1 MAKERGL-ISPSDFAQLQKYMEYSTKKVSDVLKLF-EDGEMAKYVQGDAIGYEGFQQFLK 58
M +ER + ++P +F QLQKY EYS+KK+ D L F E G + +Y + I Y+ F+ F++
Sbjct: 1 MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMR 60
Query: 59 --------------IYLEVDNVPRH---------LSLALFQSFETGHCLNETNVTK---- 91
++L PRH S + S +T + N N TK
Sbjct: 61 AYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADT-NIQNADNATKADEA 119
Query: 92 -------------------------------------DVVCLNDVSCYFSLLEGGRPEDK 114
VV L DV CY SLLE GRP+DK
Sbjct: 120 CAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDK 179
Query: 115 LEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGS 174
LEF F+LYD+D NG+LD +E+D I+ QM+ +A+YL+WD +ELRPIL+EM++ +DYD G
Sbjct: 180 LEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGF 239
Query: 175 VSQAEWVRAGATTVPLLVLLGLEMT-LKDDGQHMWRPKRFPRPVYCNLCESSI-GLGKQG 232
VS EWV G TT+PLLVLLG++ + K DG+H W K F +P YCN C + G+ KQG
Sbjct: 240 VSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQG 299
Query: 233 LSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIY 292
L C CKYTVH++C + +P V TY+K+++ SG
Sbjct: 300 LCCTYCKYTVHERCVSRNIPGCVKTYSKAKR---------------SG------------ 332
Query: 293 HSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQ 352
E H C + CD G LRDHIL P+SI P ++ + S
Sbjct: 333 -------------EFHRKC--ELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSA 377
Query: 353 KTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKD 412
K +L + +I P P THPLLV VNPKSGG+QG+R+L KF Y+LNP+QVFNL
Sbjct: 378 K--GELVMQ----YKIIPTPGTHPLLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDNG 431
Query: 413 GPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLR 472
GP GL F+D PD R+L CGGDGTVGWIL+ IDKAN PPVAVLPLGTGNDLARCLR
Sbjct: 432 GPTPGLNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLR 491
Query: 473 WGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDAS 532
WGGGYEG +L KILKD+E S +V +DRW +EVIP++ E D VP+ I+NNYFSIGVDAS
Sbjct: 492 WGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDAS 551
Query: 533 IAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNL 592
IAHRFH+MREK+PEKFNSRMKNKLWYFEF TSE+ +TCKKL + + +E G +DLSN+
Sbjct: 552 IAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNI 611
Query: 593 SLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDK 652
LEGIA+LNIPSM+GG+NLWG+ ++ + + K +TDP LK CV DLSD+
Sbjct: 612 FLEGIAILNIPSMYGGTNLWGENKKNRA-------VIRESRKGVTDPKELKFCVQDLSDQ 664
Query: 653 RLEVVGLEGAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKIT 712
LEVVGLEGA+EMGQIYT LK+AGRRLA+C+ +T T K LPMQ+DGEPWMQ CTIKIT
Sbjct: 665 LLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKIT 724
Query: 713 HKNQMPMLMGPPPRSTNF 730
HKNQ PM+MGPP +S+ F
Sbjct: 725 HKNQAPMMMGPPQKSSFF 742
>gi|4758156 diacylglycerol kinase, iota [Homo sapiens]
Length = 1065
Score = 286 bits (733), Expect = 4e-77
Identities = 193/568 (33%), Positives = 280/568 (49%), Gaps = 74/568 (13%)
Query: 203 DGQHMWRPKRFPRPVYCNLCESS--IGLGKQGL--SCNLCKYTVHDQCA-------MKAL 251
+G+H+W + C L E + + K L C +CK VH C +
Sbjct: 175 NGEHLWLETNVSGDL-CYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCK 233
Query: 252 PCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIR---IYHS--LTGLHCVWCHLE 306
P ++S ++ V+ H WV + G+C +C K + +HS + + C WC
Sbjct: 234 PTFREGGSRSPRENFVRHH-WVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQA 292
Query: 307 IHDDC----LQAVGHECDCGLLRDHILPPSSIYP------SVLASGPDRKNS----KTSQ 352
H+ L + C G I+PP+ I S+ AS +K + K S+
Sbjct: 293 FHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASK 352
Query: 353 KTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKD 412
+ M+ N ++ P PLLVFVNPKSGG QG +VL F + LNPRQVF+L ++
Sbjct: 353 RGMEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQE 412
Query: 413 GPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLR 472
GP+ L L++ VP+ RIL CGGDGTVGWIL +D+ L PPV VLPLGTGNDLAR L
Sbjct: 413 GPKDALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLN 472
Query: 473 WGGGYEGQNLAKILKDLEMSKVVHMDRWSVEV------IPQQTEEKSDPVPFQIINNYFS 526
WGGGY + ++KIL +E VV +DRW++ V P++ E+ +P + NNYFS
Sbjct: 473 WGGGYTDEPVSKILCQVEDGTVVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFS 532
Query: 527 IGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKP 586
+G DA + FH RE PEKFNSR +NK++Y A S+ + + + L + + V G
Sbjct: 533 LGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTD 592
Query: 587 L--DLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKT 644
L + L + I LNIP G+ WG+ GD +
Sbjct: 593 LTPKIQELKFQCIVFLNIPRYCAGTMPWGNP----GDHHDFEPQRH-------------- 634
Query: 645 CVPDLSDKRLEVVGLE----GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGE 700
D +EV+G A+++G G RL +C E+ T K++PMQ+DGE
Sbjct: 635 -----DDGYIEVIGFTMASLAALQVG-------GHGERLHQCREVMLLTYKSIPMQVDGE 682
Query: 701 PWMQTPCTIKITHKNQMPMLMGPPPRST 728
P P I+I+ +NQ M+ R++
Sbjct: 683 PCRLAPAMIRISLRNQANMVQKSKRRTS 710
>gi|41872507 diacylglycerol kinase zeta isoform 2 [Homo sapiens]
Length = 929
Score = 279 bits (714), Expect = 6e-75
Identities = 185/569 (32%), Positives = 271/569 (47%), Gaps = 79/569 (13%)
Query: 204 GQHMWRPKR------FPRPVYC--NLCESSIGLGKQGLSCNLCKYTVHDQCA-------M 248
G+H+W + YC + + S+ K C CK VH C
Sbjct: 96 GEHIWFETNVSGDFCYVGEQYCVARMLQKSVSRRK----CAACKIVVHTPCIEQLEKINF 151
Query: 249 KALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIR---IYHS--LTGLHCVWC 303
+ P + +++ ++ H WV + G+C C K + +HS + + C WC
Sbjct: 152 RCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWC 211
Query: 304 ----HLEIHDDCLQAVGHECDCGLLRDHILPPSSIY-----PSVLASGPDRKNS---KTS 351
H ++ LQ + C G+ ++PP+ I + L + +K + + S
Sbjct: 212 KQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKS 271
Query: 352 QKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLK 411
K + +R P P PLLVFVNPKSGG QG +++ F + LNPRQVF+L +
Sbjct: 272 SKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQ 331
Query: 412 DGPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCL 471
GP+ L +++ V + RIL CGGDGTVGWIL T+D+ L PPVA+LPLGTGNDLAR L
Sbjct: 332 GGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTL 391
Query: 472 RWGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIP-------QQTEEKSDPVPFQIINNY 524
WGGGY + ++KIL +E VV +DRW + P + E +D +P + NNY
Sbjct: 392 NWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNY 451
Query: 525 FSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICG 584
FS+G DA + FH RE PEKFNSR +NK++Y A S+ + + K L + + V G
Sbjct: 452 FSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDG 511
Query: 585 KPL--DLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDIL 642
L + +L + + LNIP G+ WG H +P
Sbjct: 512 MDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD----------------FEPQ-- 553
Query: 643 KTCVPDLSDKRLEVVGLE----GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQID 698
D LEV+G A+++G G RL +C E+ T+K +P+Q+D
Sbjct: 554 -----RHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREVVLTTSKAIPVQVD 601
Query: 699 GEPWMQTPCTIKITHKNQMPMLMGPPPRS 727
GEP I+I +NQ M+ RS
Sbjct: 602 GEPCKLAASRIRIALRNQATMVQKAKRRS 630
>gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens]
Length = 895
Score = 279 bits (714), Expect = 6e-75
Identities = 185/569 (32%), Positives = 271/569 (47%), Gaps = 79/569 (13%)
Query: 204 GQHMWRPKR------FPRPVYC--NLCESSIGLGKQGLSCNLCKYTVHDQCA-------M 248
G+H+W + YC + + S+ K C CK VH C
Sbjct: 62 GEHIWFETNVSGDFCYVGEQYCVARMLQKSVSRRK----CAACKIVVHTPCIEQLEKINF 117
Query: 249 KALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIR---IYHS--LTGLHCVWC 303
+ P + +++ ++ H WV + G+C C K + +HS + + C WC
Sbjct: 118 RCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWC 177
Query: 304 ----HLEIHDDCLQAVGHECDCGLLRDHILPPSSIY-----PSVLASGPDRKNS---KTS 351
H ++ LQ + C G+ ++PP+ I + L + +K + + S
Sbjct: 178 KQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKS 237
Query: 352 QKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLK 411
K + +R P P PLLVFVNPKSGG QG +++ F + LNPRQVF+L +
Sbjct: 238 SKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQ 297
Query: 412 DGPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCL 471
GP+ L +++ V + RIL CGGDGTVGWIL T+D+ L PPVA+LPLGTGNDLAR L
Sbjct: 298 GGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTL 357
Query: 472 RWGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIP-------QQTEEKSDPVPFQIINNY 524
WGGGY + ++KIL +E VV +DRW + P + E +D +P + NNY
Sbjct: 358 NWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNY 417
Query: 525 FSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICG 584
FS+G DA + FH RE PEKFNSR +NK++Y A S+ + + K L + + V G
Sbjct: 418 FSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDG 477
Query: 585 KPL--DLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDIL 642
L + +L + + LNIP G+ WG H +P
Sbjct: 478 MDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD----------------FEPQ-- 519
Query: 643 KTCVPDLSDKRLEVVGLE----GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQID 698
D LEV+G A+++G G RL +C E+ T+K +P+Q+D
Sbjct: 520 -----RHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREVVLTTSKAIPVQVD 567
Query: 699 GEPWMQTPCTIKITHKNQMPMLMGPPPRS 727
GEP I+I +NQ M+ RS
Sbjct: 568 GEPCKLAASRIRIALRNQATMVQKAKRRS 596
>gi|157688564 diacylglycerol kinase zeta isoform 4 [Homo sapiens]
Length = 1117
Score = 279 bits (713), Expect = 8e-75
Identities = 178/530 (33%), Positives = 258/530 (48%), Gaps = 67/530 (12%)
Query: 235 CNLCKYTVHDQCA-------MKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQK 287
C CK VH C + P + +++ ++ H WV + G+C C K
Sbjct: 319 CAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGK 378
Query: 288 KIR---IYHS--LTGLHCVWC----HLEIHDDCLQAVGHECDCGLLRDHILPPSSIY--- 335
+ +HS + + C WC H ++ LQ + C G+ ++PP+ I
Sbjct: 379 GFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRAR 438
Query: 336 --PSVLASGPDRKNS---KTSQKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQG 390
+ L + +K + + S K + +R P P PLLVFVNPKSGG QG
Sbjct: 439 RPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQG 498
Query: 391 QRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANL 450
+++ F + LNPRQVF+L + GP+ L +++ V + RIL CGGDGTVGWIL T+D+ L
Sbjct: 499 AKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRL 558
Query: 451 PVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIP---- 506
PPVA+LPLGTGNDLAR L WGGGY + ++KIL +E VV +DRW + P
Sbjct: 559 KPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEA 618
Query: 507 ---QQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFAT 563
+ E +D +P + NNYFS+G DA + FH RE PEKFNSR +NK++Y A
Sbjct: 619 GPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAF 678
Query: 564 SESIFSTCKKLEESLTVEICGKPL--DLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGD 621
S+ + + K L + + V G L + +L + + LNIP G+ WG H
Sbjct: 679 SDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD- 737
Query: 622 IYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE----GAIEMGQIYTKLKNAGR 677
+P D LEV+G A+++G G
Sbjct: 738 ---------------FEPQ-------RHDDGYLEVIGFTMTSLAALQVG-------GHGE 768
Query: 678 RLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPMLMGPPPRS 727
RL +C E+ T+K +P+Q+DGEP I+I +NQ M+ RS
Sbjct: 769 RLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRS 818
>gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens]
Length = 945
Score = 279 bits (713), Expect = 8e-75
Identities = 178/530 (33%), Positives = 258/530 (48%), Gaps = 67/530 (12%)
Query: 235 CNLCKYTVHDQCA-------MKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQK 287
C CK VH C + P + +++ ++ H WV + G+C C K
Sbjct: 147 CAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGK 206
Query: 288 KIR---IYHS--LTGLHCVWC----HLEIHDDCLQAVGHECDCGLLRDHILPPSSIY--- 335
+ +HS + + C WC H ++ LQ + C G+ ++PP+ I
Sbjct: 207 GFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRAR 266
Query: 336 --PSVLASGPDRKNS---KTSQKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQG 390
+ L + +K + + S K + +R P P PLLVFVNPKSGG QG
Sbjct: 267 RPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQG 326
Query: 391 QRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANL 450
+++ F + LNPRQVF+L + GP+ L +++ V + RIL CGGDGTVGWIL T+D+ L
Sbjct: 327 AKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRL 386
Query: 451 PVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIP---- 506
PPVA+LPLGTGNDLAR L WGGGY + ++KIL +E VV +DRW + P
Sbjct: 387 KPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEA 446
Query: 507 ---QQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFAT 563
+ E +D +P + NNYFS+G DA + FH RE PEKFNSR +NK++Y A
Sbjct: 447 GPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAF 506
Query: 564 SESIFSTCKKLEESLTVEICGKPL--DLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGD 621
S+ + + K L + + V G L + +L + + LNIP G+ WG H
Sbjct: 507 SDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD- 565
Query: 622 IYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE----GAIEMGQIYTKLKNAGR 677
+P D LEV+G A+++G G
Sbjct: 566 ---------------FEPQ-------RHDDGYLEVIGFTMTSLAALQVG-------GHGE 596
Query: 678 RLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPMLMGPPPRS 727
RL +C E+ T+K +P+Q+DGEP I+I +NQ M+ RS
Sbjct: 597 RLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRS 646
>gi|4503313 diacylglycerol kinase epsilon [Homo sapiens]
Length = 567
Score = 276 bits (706), Expect = 5e-74
Identities = 184/538 (34%), Positives = 261/538 (48%), Gaps = 75/538 (13%)
Query: 205 QHMWRPKR-FPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKA---LPCEVSTYAK 260
+H WR F +P YC +C I QG C+ C V + C KA C+
Sbjct: 59 KHGWRDTDLFSQPTYCCVCAQHI---LQGAFCDCCGLRVDEGCLRKADKRFQCKEIMLKN 115
Query: 261 SRKDIGVQSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQ--AVGH 317
K + H W+RG C C+++ L C+WC +HD+C++
Sbjct: 116 DTKVLDAMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMKNSLKNE 175
Query: 318 ECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNTHPL 377
+CD G ++ I+PPS + + RK+ KT E L PL
Sbjct: 176 KCDFGEFKNLIIPPSYL----TSINQMRKDKKTDY-----------EVLASKLGKQWTPL 220
Query: 378 LVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVP--DSRILVCGGD 435
++ N +SG G+ +L +F+ +LNP QVF++ K P L+L +P +R+LVCGGD
Sbjct: 221 IILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCGGD 280
Query: 436 GTVGWILETID----KANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ-NLAKILKDLE 490
GTVGW+L+ +D K +P VAVLPLGTGNDL+ L WG GY G+ +A++L+++
Sbjct: 281 GTVGWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVM 340
Query: 491 MSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYPEKFNS 550
+ + +DRW V+V + P F + NNYFS+G DA +A FH REK P F+S
Sbjct: 341 EADGIKLDRWKVQVTNKGYYNLRKPKEFTM-NNYFSVGPDALMALNFHAHREKAPSLFSS 399
Query: 551 RMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSMHGGSN 610
R+ NK Y + T + + CK L + + +E+ G+ + L SLEGI VLNI GG
Sbjct: 400 RILNKAVYLFYGTKDCLVQECKDLNKKVELELDGERVALP--SLEGIIVLNIGYWGGGCR 457
Query: 611 LWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEGAIEMGQIYT 670
LW + +G + D D LEVVG+ G+ QI
Sbjct: 458 LW--------------EGMGDETYPLARHD----------DGLLEVVGVYGSFHCAQIQV 493
Query: 671 KLKN--------AGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML 720
KL N R + KCS +PMQ+DGEPW Q PCT+ ITHK ML
Sbjct: 494 KLANPFRIGQAHTVRLILKCS--------MMPMQVDGEPWAQGPCTVTITHKTHAMML 543
Score = 32.7 bits (73), Expect = 1.2
Identities = 20/66 (30%), Positives = 29/66 (43%), Gaps = 8/66 (12%)
Query: 197 EMTLKDDGQ------HMWRPKRFPRPVYCNLCESSIGLGKQ--GLSCNLCKYTVHDQCAM 248
E+ LK+D + H W P YC +C+ G + C C+ TVHD+C
Sbjct: 110 EIMLKNDTKVLDAMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMK 169
Query: 249 KALPCE 254
+L E
Sbjct: 170 NSLKNE 175
>gi|40806175 diacylglycerol kinase, theta [Homo sapiens]
Length = 942
Score = 228 bits (580), Expect = 2e-59
Identities = 133/344 (38%), Positives = 195/344 (56%), Gaps = 38/344 (11%)
Query: 372 PNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILV 431
P++ PLLVFVNPKSGG +G+ +L F+ +LNP QVF+L GP GL LF VP R+LV
Sbjct: 584 PDSCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLV 643
Query: 432 CGGDGTVGWILETIDKANLPVL---PPVAVLPLGTGNDLARCLRWGGGYEGQNLAKILKD 488
CGGDGTVGW+L +++ + P VA+LPLGTGNDL R LRWG GY G++ +L
Sbjct: 644 CGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLLS 703
Query: 489 LEMSKVVHMDRWSVEVIPQQT----EEKSDPVPFQII--NNYFSIGVDASIAHRFHIMRE 542
++ + V MDRW++ + + + +D P +I+ +NY IG+DA ++ FH RE
Sbjct: 704 VDEADAVLMDRWTILLDAHEAGSAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQARE 763
Query: 543 KYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNI 602
+ P KF SR+ NK Y + S + L + + +++ + ++L S+EG+ +NI
Sbjct: 764 EEPGKFTSRLHNKGVYVRVGLQK--ISHSRSLHKQIRLQVERQEVELP--SIEGLIFINI 819
Query: 603 PSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEGA 662
PS G++LWG +D K P + D LEVVG+ G
Sbjct: 820 PSWGSGADLWGSD---------------------SDTRFEK---PRMDDGLLEVVGVTGV 855
Query: 663 IEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTP 706
+ MGQ+ L++ G R+A+ S K P+Q+DGEPW+Q P
Sbjct: 856 VHMGQVQGGLRS-GIRIAQGSYFRVTLLKATPVQVDGEPWVQAP 898
Score = 68.9 bits (167), Expect = 2e-11
Identities = 37/130 (28%), Positives = 56/130 (43%), Gaps = 3/130 (2%)
Query: 206 HMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDI 265
H + P+ + +C +C L L C +C+ +H C A + +D
Sbjct: 122 HCFGPRGLHKRKFCAVCRKV--LEAPALHCEVCELHLHPDCVPFACSDCRQCHQDGHQDH 179
Query: 266 GVQSHVWVRGGCESG-RCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLL 324
H W G SG RC+ C+K L G+ C WC ++ H C A+ EC G L
Sbjct: 180 DTHHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGRL 239
Query: 325 RDHILPPSSI 334
R +LPP+ +
Sbjct: 240 RSLVLPPACV 249
Score = 52.4 bits (124), Expect = 2e-06
Identities = 32/115 (27%), Positives = 51/115 (44%), Gaps = 8/115 (6%)
Query: 206 HMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKA-LPCEVSTYAKSRKD 264
H +R +P +C+LC I G G C++C + H++C +PC ++ A S
Sbjct: 61 HSFRKVTLTKPTFCHLCSDFIW-GLAGFLCDVCNFMSHEKCLKHVRIPC--TSVAPSLVR 117
Query: 265 IGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHEC 319
+ V RG + C C+K + LHC C L +H DC+ +C
Sbjct: 118 VPVAHCFGPRGLHKRKFCAVCRKVL----EAPALHCEVCELHLHPDCVPFACSDC 168
>gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo
sapiens]
Length = 1170
Score = 206 bits (523), Expect = 8e-53
Identities = 119/309 (38%), Positives = 165/309 (53%), Gaps = 32/309 (10%)
Query: 204 GQHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALP-CEVSTYAKS 261
G H W RP YCN+C ++ G+ GLSC +CK+ H +CA++A C+ +T A
Sbjct: 118 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 177
Query: 262 RKDI-----GV-QSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQA 314
KDI G+ H W+ G S +C C K L C+WC +H C ++
Sbjct: 178 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 237
Query: 315 VGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNT 374
+ +C GL + ++PP+++ S+ + G + + P T
Sbjct: 238 LLTKCPLGLCKVSVIPPTALN-SIDSDGFWKASC---------------------PPSCT 275
Query: 375 HPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGG 434
PLLVFVN KSG QG + L +F+ +LNP QVF+L+ GP +GLRLF+ RILVCGG
Sbjct: 276 SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGG 335
Query: 435 DGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ-NLAKILKDLEMSK 493
DG+VGW+L ID NL + VLPLGTGNDLAR L WG + L +IL+ LE +
Sbjct: 336 DGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERAS 395
Query: 494 VVHMDRWSV 502
+DRWSV
Sbjct: 396 TKMLDRWSV 404
Score = 126 bits (317), Expect = 6e-29
Identities = 75/203 (36%), Positives = 112/203 (55%), Gaps = 28/203 (13%)
Query: 520 IINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLT 579
++NNYF IG+DA I+ F+ R+++PEK SR KN +WY T E + T K LE+ +
Sbjct: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778
Query: 580 VEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDP 639
+E G+P+ L SL+GIAVLNIPS GG+N WG T+ D +
Sbjct: 779 LECDGRPIPLP--SLQGIAVLNIPSYAGGTNFWGGTK--EDDTF---------------- 818
Query: 640 DILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCS--EITFHTTKTLPMQI 697
P DK LEVV + G+++M + ++ R+A+C +I+ + +P+Q+
Sbjct: 819 -----AAPSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQV 872
Query: 698 DGEPWMQTPCTIKITHKNQMPML 720
DGE W+Q P I+I HKN+ L
Sbjct: 873 DGEAWVQPPGYIRIVHKNRAQTL 895
>gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo
sapiens]
Length = 1214
Score = 206 bits (523), Expect = 8e-53
Identities = 119/309 (38%), Positives = 165/309 (53%), Gaps = 32/309 (10%)
Query: 204 GQHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALP-CEVSTYAKS 261
G H W RP YCN+C ++ G+ GLSC +CK+ H +CA++A C+ +T A
Sbjct: 162 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 221
Query: 262 RKDI-----GV-QSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQA 314
KDI G+ H W+ G S +C C K L C+WC +H C ++
Sbjct: 222 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 281
Query: 315 VGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNT 374
+ +C GL + ++PP+++ S+ + G + + P T
Sbjct: 282 LLTKCPLGLCKVSVIPPTALN-SIDSDGFWKASC---------------------PPSCT 319
Query: 375 HPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGG 434
PLLVFVN KSG QG + L +F+ +LNP QVF+L+ GP +GLRLF+ RILVCGG
Sbjct: 320 SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGG 379
Query: 435 DGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ-NLAKILKDLEMSK 493
DG+VGW+L ID NL + VLPLGTGNDLAR L WG + L +IL+ LE +
Sbjct: 380 DGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERAS 439
Query: 494 VVHMDRWSV 502
+DRWSV
Sbjct: 440 TKMLDRWSV 448
Score = 126 bits (317), Expect = 6e-29
Identities = 75/203 (36%), Positives = 112/203 (55%), Gaps = 28/203 (13%)
Query: 520 IINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLT 579
++NNYF IG+DA I+ F+ R+++PEK SR KN +WY T E + T K LE+ +
Sbjct: 763 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 822
Query: 580 VEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDP 639
+E G+P+ L SL+GIAVLNIPS GG+N WG T+ D +
Sbjct: 823 LECDGRPIPLP--SLQGIAVLNIPSYAGGTNFWGGTK--EDDTF---------------- 862
Query: 640 DILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCS--EITFHTTKTLPMQI 697
P DK LEVV + G+++M + ++ R+A+C +I+ + +P+Q+
Sbjct: 863 -----AAPSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQV 916
Query: 698 DGEPWMQTPCTIKITHKNQMPML 720
DGE W+Q P I+I HKN+ L
Sbjct: 917 DGEAWVQPPGYIRIVHKNRAQTL 939
>gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens]
Length = 1164
Score = 205 bits (521), Expect = 1e-52
Identities = 125/324 (38%), Positives = 166/324 (51%), Gaps = 33/324 (10%)
Query: 204 GQHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALP-CEVSTYAKS 261
G H W RP +CN+C S+ G+ GLSC +CK+ H +CA++A C+ +T A
Sbjct: 174 GMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 233
Query: 262 RKDI-----GV-QSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQA 314
KDI GV H W+ G S +C C K L C+WC +H C
Sbjct: 234 GKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDL 293
Query: 315 VGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNT 374
C G + I+PP ++ NS S D +T
Sbjct: 294 YHPICPLGQCKVSIIPPIAL------------NSTDS----DGFCRATFSFC-------V 330
Query: 375 HPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGG 434
PLLVFVN KSG QG + L +F+ +LNP QVF+L+ GP +GLRLF+ + RILVCGG
Sbjct: 331 SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGG 390
Query: 435 DGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ-NLAKILKDLEMSK 493
DG+VGW+L IDK NL + VLPLGTGNDLAR L WGG Y+ L +IL+ LE +
Sbjct: 391 DGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERAS 450
Query: 494 VVHMDRWSVEVIPQQTEEKSDPVP 517
+DRWS+ + K+ +P
Sbjct: 451 TKMLDRWSIMTYELKLPPKASLLP 474
Score = 127 bits (320), Expect = 3e-29
Identities = 78/203 (38%), Positives = 112/203 (55%), Gaps = 28/203 (13%)
Query: 520 IINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLT 579
++NNYF IG+DA I+ F+ RE++PEK SR KN +WY T E + + K LE+ +
Sbjct: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829
Query: 580 VEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDP 639
+E G+ + L SL+GIAVLNIPS GG+N WG T+ DI+
Sbjct: 830 LECDGQYIPLP--SLQGIAVLNIPSYAGGTNFWGGTK--EDDIF---------------- 869
Query: 640 DILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCS--EITFHTTKTLPMQI 697
P DK LEVV + +++M + +K R+A+C +IT + +P+Q+
Sbjct: 870 -----AAPSFDDKILEVVAIFDSMQMA-VSRVIKLQHHRIAQCRTVKITIFGDEGVPVQV 923
Query: 698 DGEPWMQTPCTIKITHKNQMPML 720
DGE W+Q P IKI HKN+ ML
Sbjct: 924 DGEAWVQPPGIIKIVHKNRAQML 946
>gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens]
Length = 1220
Score = 205 bits (521), Expect = 1e-52
Identities = 125/324 (38%), Positives = 166/324 (51%), Gaps = 33/324 (10%)
Query: 204 GQHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALP-CEVSTYAKS 261
G H W RP +CN+C S+ G+ GLSC +CK+ H +CA++A C+ +T A
Sbjct: 174 GMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 233
Query: 262 RKDI-----GV-QSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQA 314
KDI GV H W+ G S +C C K L C+WC +H C
Sbjct: 234 GKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDL 293
Query: 315 VGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNT 374
C G + I+PP ++ NS S D +T
Sbjct: 294 YHPICPLGQCKVSIIPPIAL------------NSTDS----DGFCRATFSFC-------V 330
Query: 375 HPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGG 434
PLLVFVN KSG QG + L +F+ +LNP QVF+L+ GP +GLRLF+ + RILVCGG
Sbjct: 331 SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGG 390
Query: 435 DGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ-NLAKILKDLEMSK 493
DG+VGW+L IDK NL + VLPLGTGNDLAR L WGG Y+ L +IL+ LE +
Sbjct: 391 DGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERAS 450
Query: 494 VVHMDRWSVEVIPQQTEEKSDPVP 517
+DRWS+ + K+ +P
Sbjct: 451 TKMLDRWSIMTYELKLPPKASLLP 474
Score = 127 bits (320), Expect = 3e-29
Identities = 78/203 (38%), Positives = 112/203 (55%), Gaps = 28/203 (13%)
Query: 520 IINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLT 579
++NNYF IG+DA I+ F+ RE++PEK SR KN +WY T E + + K LE+ +
Sbjct: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829
Query: 580 VEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDP 639
+E G+ + L SL+GIAVLNIPS GG+N WG T+ DI+
Sbjct: 830 LECDGQYIPLP--SLQGIAVLNIPSYAGGTNFWGGTK--EDDIF---------------- 869
Query: 640 DILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCS--EITFHTTKTLPMQI 697
P DK LEVV + +++M + +K R+A+C +IT + +P+Q+
Sbjct: 870 -----AAPSFDDKILEVVAIFDSMQMA-VSRVIKLQHHRIAQCRTVKITIFGDEGVPVQV 923
Query: 698 DGEPWMQTPCTIKITHKNQMPML 720
DGE W+Q P IKI HKN+ ML
Sbjct: 924 DGEAWVQPPGIIKIVHKNRAQML 946
>gi|62000702 diacylglycerol kinase kappa [Homo sapiens]
Length = 1271
Score = 191 bits (486), Expect = 2e-48
Identities = 119/317 (37%), Positives = 161/317 (50%), Gaps = 26/317 (8%)
Query: 204 GQHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALP-CEVSTYAKS 261
G H W R +CN+C SI L + + C +CK H CA++A C+ +T + +
Sbjct: 326 GMHCWYSSYSHRTQHCNVCRESIPALSRDAIICEVCKVKSHRLCALRASKDCKWNTLSIT 385
Query: 262 RK-----DIGVQSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAV 315
D H WV G S +C C + Y L C+WC+ +HDDC +
Sbjct: 386 DDLLLPADEVNMPHQWVEGNMPVSSQCAVCHESCGSYQRLQDFRCLWCNSTVHDDCRRRF 445
Query: 316 GHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNTH 375
EC R ++PP+++ D K + D NL S A
Sbjct: 446 SKECCFRSHRSSVIPPTAL--------SDPKGDGQLVVSSDFWNLDWSSACSC------- 490
Query: 376 PLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGGD 435
PLL+F+N KSG QG L KF+ LNP QVF+LLK GPE GL +FK+ RILVCGGD
Sbjct: 491 PLLIFINSKSGDHQGIVFLRKFKQYLNPSQVFDLLKGGPEAGLSMFKNFARFRILVCGGD 550
Query: 436 GTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGY-EGQNLAKILKDLEMSKV 494
G+V W+L ID L +AV+PLGTGNDLAR L WG + + ++ IL +E + V
Sbjct: 551 GSVSWVLSLIDAFGLHEKCQLAVIPLGTGNDLARVLGWGAFWNKSKSPLDILNRVEQASV 610
Query: 495 VHMDRWSVEV--IPQQT 509
+DRWSV + P+QT
Sbjct: 611 RILDRWSVMIRETPRQT 627
Score = 121 bits (304), Expect = 2e-27
Identities = 75/204 (36%), Positives = 113/204 (55%), Gaps = 30/204 (14%)
Query: 520 IINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLT 579
++NNYF IG+DA I+ F+ R+++P ++NSR+KNK+WY T E + + +KLEE +
Sbjct: 857 VMNNYFGIGLDAKISLDFNTRRDEHPGQYNSRLKNKMWYGLLGTKELLQRSYRKLEERVH 916
Query: 580 VEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDP 639
+E G+ + L NL +GI VLNI S GG N WG AT +
Sbjct: 917 LECDGETISLPNL--QGIVVLNITSYAGGINFWGSNT--------------ATTEYEA-- 958
Query: 640 DILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGR-RLAKCSE--ITFHTTKTLPMQ 696
P + D +LEVV + G+++M +++ N R+A+C E IT + +P+Q
Sbjct: 959 -------PAIDDGKLEVVAIFGSVQMAM--SRIINLHHHRIAQCHEVMITIDGEEGIPVQ 1009
Query: 697 IDGEPWMQTPCTIKITHKNQMPML 720
+DGE W+Q P IKI +KN ML
Sbjct: 1010 VDGEAWIQRPGLIKIRYKNAAQML 1033
>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
sapiens]
Length = 1551
Score = 57.4 bits (137), Expect = 5e-08
Identities = 26/53 (49%), Positives = 31/53 (58%), Gaps = 1/53 (1%)
Query: 204 GQHMWRPKRFPRPVYCNLCES-SIGLGKQGLSCNLCKYTVHDQCAMKALPCEV 255
G H RP+ FP P C C S +GLG+QGL C+ C Y H CA +A PC V
Sbjct: 877 GSHTLRPRSFPSPTKCLRCTSLMLGLGRQGLGCDACGYFCHTTCAPQAPPCPV 929
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 52.4 bits (124), Expect = 2e-06
Identities = 52/214 (24%), Positives = 86/214 (40%), Gaps = 28/214 (13%)
Query: 206 HMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQC-AMKALPCEVSTYAKSRK 263
H + + F +P +C+ C I G+GKQGL C +C + VH +C C +
Sbjct: 36 HKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTD 95
Query: 264 DIGVQSHVWVRGGCESGRCDRCQKKI-RIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCG 322
D + + CD C + + H G+ C C + +H C+++V C
Sbjct: 96 DPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQ--GMKCSCCEMNVHRRCVRSVPSLCGV- 152
Query: 323 LLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPV-PN--THP--- 376
DH R + T D+++++ EA + P+ PN + P
Sbjct: 153 ---DH------------TERRGRLQLEIRAPTADEIHVTVGEARNLIPMDPNGLSDPYVK 197
Query: 377 LLVFVNPKSGGKQGQR-VLWKFQYILNPRQVFNL 409
L + +P++ KQ R V + N VFNL
Sbjct: 198 LKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNL 231
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 48.1 bits (113), Expect = 3e-05
Identities = 31/116 (26%), Positives = 47/116 (40%), Gaps = 10/116 (8%)
Query: 213 FPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRK-------- 263
F +P +C++C+ + GL KQG C C +H +C K + T A SR
Sbjct: 166 FGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERF 225
Query: 264 DIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHEC 319
+I + V CD C + GL C C + +H C + V + C
Sbjct: 226 NIDMPHRFKVHNYMSPTFCDHCGSLLWGLVK-QGLKCEDCGMNVHHKCREKVANLC 280
>gi|31377782 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 48.1 bits (113), Expect = 3e-05
Identities = 31/116 (26%), Positives = 47/116 (40%), Gaps = 10/116 (8%)
Query: 213 FPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRK-------- 263
F +P +C++C+ + GL KQG C C +H +C K + T A SR
Sbjct: 166 FGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERF 225
Query: 264 DIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHEC 319
+I + V CD C + GL C C + +H C + V + C
Sbjct: 226 NIDMPHRFKVHNYMSPTFCDHCGSLLWGLVK-QGLKCEDCGMNVHHKCREKVANLC 280
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 47.8 bits (112), Expect = 4e-05
Identities = 45/183 (24%), Positives = 69/183 (37%), Gaps = 20/183 (10%)
Query: 206 HMWRPKRFPRPVYCNLCESSIG--LGKQGLSCNLCKYTVHDQC---AMKALPCE------ 254
H + +P YC+ C I GKQG C +C VH +C + A C+
Sbjct: 172 HKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNINKV 231
Query: 255 VSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQA 314
S A+ R I + + CD C + GL C C + +H C
Sbjct: 232 DSKIAEQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGI-MRQGLQCKICKMNVHIRCQAN 290
Query: 315 VGHECDCG------LLRDHILPPSSIYPS--VLASGPDRKNSKTSQKTMDDLNLSTSEAL 366
V C L L P +I P+ +++ R+ K S K + + +++S L
Sbjct: 291 VAPNCGVNAVELAKTLAGMGLQPGNISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNRL 350
Query: 367 RID 369
ID
Sbjct: 351 GID 353
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 47.4 bits (111), Expect = 5e-05
Identities = 29/117 (24%), Positives = 47/117 (40%), Gaps = 5/117 (4%)
Query: 206 HMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQC-AMKALPCEVSTYAKSRK 263
H + + F +P +C+ C I G GKQG C +C + VH +C C + +
Sbjct: 37 HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASD 96
Query: 264 DIGVQSHVWVRGGCESGRCDRCQKKI-RIYHSLTGLHCVWCHLEIHDDCLQAVGHEC 319
D + + CD C + + H G+ C C + +H C+ V C
Sbjct: 97 DPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQ--GMKCDTCMMNVHKRCVMNVPSLC 151
Score = 41.2 bits (95), Expect = 0.003
Identities = 19/68 (27%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 205 QHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRK 263
+H ++ + P +C+ C S + GL QG+ C+ C VH +C M + + + R
Sbjct: 101 KHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRG 160
Query: 264 DIGVQSHV 271
I +Q+H+
Sbjct: 161 RIYIQAHI 168
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 47.4 bits (111), Expect = 5e-05
Identities = 29/117 (24%), Positives = 47/117 (40%), Gaps = 5/117 (4%)
Query: 206 HMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQC-AMKALPCEVSTYAKSRK 263
H + + F +P +C+ C I G GKQG C +C + VH +C C + +
Sbjct: 37 HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASD 96
Query: 264 DIGVQSHVWVRGGCESGRCDRCQKKI-RIYHSLTGLHCVWCHLEIHDDCLQAVGHEC 319
D + + CD C + + H G+ C C + +H C+ V C
Sbjct: 97 DPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQ--GMKCDTCMMNVHKRCVMNVPSLC 151
Score = 41.2 bits (95), Expect = 0.003
Identities = 19/68 (27%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 205 QHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRK 263
+H ++ + P +C+ C S + GL QG+ C+ C VH +C M + + + R
Sbjct: 101 KHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRG 160
Query: 264 DIGVQSHV 271
I +Q+H+
Sbjct: 161 RIYIQAHI 168
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 47.4 bits (111), Expect = 5e-05
Identities = 31/123 (25%), Positives = 49/123 (39%), Gaps = 10/123 (8%)
Query: 206 HMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMK--------ALPCEVS 256
H + FP+P +C++C + GL KQG C C +H +C K A+ +
Sbjct: 160 HEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRET 219
Query: 257 TYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVG 316
+ K R I + V C+ C + + GL C C + +H C V
Sbjct: 220 MFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGL-ARQGLKCDACGMNVHHRCQTKVA 278
Query: 317 HEC 319
+ C
Sbjct: 279 NLC 281
Score = 38.9 bits (89), Expect = 0.017
Identities = 17/50 (34%), Positives = 26/50 (52%), Gaps = 1/50 (2%)
Query: 201 KDDGQHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMK 249
K D H ++ + P +C C + + GL +QGL C+ C VH +C K
Sbjct: 227 KIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTK 276
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 46.2 bits (108), Expect = 1e-04
Identities = 51/205 (24%), Positives = 79/205 (38%), Gaps = 25/205 (12%)
Query: 206 HMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQC-AMKALPCEVSTYAKSRK 263
H + + F +P +C+ C I G GKQG C +C + VH +C C +
Sbjct: 37 HKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTD 96
Query: 264 DIGVQSHVWVRGGCESGRCDRCQKKI-RIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCG 322
D + + CD C + + H G+ C C + +H C+ V C
Sbjct: 97 DPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQ--GMKCDTCDMNVHKQCVINVPSLCG-- 152
Query: 323 LLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNTHP---LLV 379
DH IY + A D K T D NL + +DP + P L +
Sbjct: 153 --MDHTEKRGRIY--LKAEVADEKLHVT---VRDAKNL-----IPMDPNGLSDPYVKLKL 200
Query: 380 FVNPKSGGKQGQRVLWKFQYILNPR 404
+PK+ KQ + + + LNP+
Sbjct: 201 IPDPKNESKQKTKTI---RSTLNPQ 222
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,885,059
Number of Sequences: 37866
Number of extensions: 1394310
Number of successful extensions: 3662
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 71
Number of HSP's successfully gapped in prelim test: 87
Number of HSP's that attempted gapping in prelim test: 3314
Number of HSP's gapped (non-prelim): 280
length of query: 735
length of database: 18,247,518
effective HSP length: 110
effective length of query: 625
effective length of database: 14,082,258
effective search space: 8801411250
effective search space used: 8801411250
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.