Search of human proteins with 31077215

Search of human proteins with 31077215

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|31077215 HUS1 checkpoint protein B [Homo sapiens]
         (278 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|31077215 HUS1 checkpoint protein B [Homo sapiens]                  548   e-156
gi|4758576 HUS1 checkpoint protein [Homo sapiens]                     277   6e-75
gi|28411948 oligodendrocyte transcription factor 3 [Homo sapiens]      34   0.16 
gi|21735548 centrosomal protein 2 [Homo sapiens]                       32   0.61 
gi|4504831 potassium voltage-gated channel, subfamily H, member ...    31   1.0  
gi|27437001 potassium voltage-gated channel, subfamily H, member...    31   1.0  
gi|47157315 Janus kinase 3 [Homo sapiens]                              30   1.8  
gi|126723390 ankyrin repeat domain 24 [Homo sapiens]                   30   2.3  
gi|110349719 titin isoform N2-A [Homo sapiens]                         29   5.2  
gi|118197272 ATG2 autophagy related 2 homolog B [Homo sapiens]         28   8.8  
gi|51479173 dynein, axonemal, heavy chain 11 [Homo sapiens]            28   8.8  

>gi|31077215 HUS1 checkpoint protein B [Homo sapiens]
          Length = 278

 Score =  548 bits (1412), Expect = e-156
 Identities = 278/278 (100%), Positives = 278/278 (100%)

Query: 1   MKFRAKITGKGCLELFIHVSGTVARLAKVCVLRVRPDSLCFGPAGSGGLHEARLWCEVRQ 60
           MKFRAKITGKGCLELFIHVSGTVARLAKVCVLRVRPDSLCFGPAGSGGLHEARLWCEVRQ
Sbjct: 1   MKFRAKITGKGCLELFIHVSGTVARLAKVCVLRVRPDSLCFGPAGSGGLHEARLWCEVRQ 60

Query: 61  GAFQQFRMEGVSEDLDEIHLELTAEHLSRAARSAAGASSLKLQLTHKRRPSLTVAVELVS 120
           GAFQQFRMEGVSEDLDEIHLELTAEHLSRAARSAAGASSLKLQLTHKRRPSLTVAVELVS
Sbjct: 61  GAFQQFRMEGVSEDLDEIHLELTAEHLSRAARSAAGASSLKLQLTHKRRPSLTVAVELVS 120

Query: 121 SLGRARSVVHDLPVRVLPRRVWRDCLPPSLRASDASIRLPRWRTLRSIVERMANVGSHVL 180
           SLGRARSVVHDLPVRVLPRRVWRDCLPPSLRASDASIRLPRWRTLRSIVERMANVGSHVL
Sbjct: 121 SLGRARSVVHDLPVRVLPRRVWRDCLPPSLRASDASIRLPRWRTLRSIVERMANVGSHVL 180

Query: 181 VEANLSGRMTLSIETEVVSIQSYFKNLGNPPQSAVGVPENRDLESMVQVRVDNRKLLQFL 240
           VEANLSGRMTLSIETEVVSIQSYFKNLGNPPQSAVGVPENRDLESMVQVRVDNRKLLQFL
Sbjct: 181 VEANLSGRMTLSIETEVVSIQSYFKNLGNPPQSAVGVPENRDLESMVQVRVDNRKLLQFL 240

Query: 241 EGQQIHPTTALCNIWDNTLLQLVLVQEDVSLQYFIPAL 278
           EGQQIHPTTALCNIWDNTLLQLVLVQEDVSLQYFIPAL
Sbjct: 241 EGQQIHPTTALCNIWDNTLLQLVLVQEDVSLQYFIPAL 278


>gi|4758576 HUS1 checkpoint protein [Homo sapiens]
          Length = 280

 Score =  277 bits (709), Expect = 6e-75
 Identities = 139/282 (49%), Positives = 200/282 (70%), Gaps = 7/282 (2%)

Query: 1   MKFRAKITGKGCLELFIHVSGTVARLAKVCVLRVRPDSLCF---GPAGSGGLHEARLWCE 57
           MKFRAKI    CL  F  +S  +A+LAK C LR+ PD L F       +GG+    +WCE
Sbjct: 1   MKFRAKIVDGACLNHFTRISNMIAKLAKTCTLRISPDKLNFILCDKLANGGVS---MWCE 57

Query: 58  VRQ-GAFQQFRMEGVSEDLDEIHLELTAEHLSRAARSAAGASSLKLQLTHKRRPSLTVAV 116
           + Q   F +F+MEGVS + +EI+LELT+E+LSRA ++A  A +LK++LT+K  P LTV+V
Sbjct: 58  LEQENFFNEFQMEGVSAENNEIYLELTSENLSRALKTAQNARALKIKLTNKHFPCLTVSV 117

Query: 117 ELVSSLGRARSVVHDLPVRVLPRRVWRDCLPPSLRASDASIRLPRWRTLRSIVERMANVG 176
           EL+S    +R V HD+P++V+PR++W+D   P +   D SI LP  +T++S+VE+M N+ 
Sbjct: 118 ELLSMSSSSRIVTHDIPIKVIPRKLWKDLQEPVVPDPDVSIYLPVLKTMKSVVEKMKNIS 177

Query: 177 SHVLVEANLSGRMTLSIETEVVSIQSYFKNLGNPPQSAVGVPENRDLESMVQVRVDNRKL 236
           +H+++EANL G + L IETE+V + ++FK+LGNPP ++    E+R++E M +V +D RKL
Sbjct: 178 NHLVIEANLDGELNLKIETELVCVTTHFKDLGNPPLASESTHEDRNVEHMAEVHIDIRKL 237

Query: 237 LQFLEGQQIHPTTALCNIWDNTLLQLVLVQEDVSLQYFIPAL 278
           LQFL GQQ++PT ALCNI +N ++   L+ EDVSLQYFIPAL
Sbjct: 238 LQFLAGQQVNPTKALCNIVNNKMVHFDLLHEDVSLQYFIPAL 279


>gi|28411948 oligodendrocyte transcription factor 3 [Homo sapiens]
          Length = 272

 Score = 33.9 bits (76), Expect = 0.16
 Identities = 24/72 (33%), Positives = 36/72 (50%), Gaps = 8/72 (11%)

Query: 64  QQFRMEGVSEDLDEIHLELTAEHLSRAARSAAGASS---LKLQLTHKRRPSLTVAVELVS 120
           Q+ R+  VS    ++  ++  E LSRA   AAG SS   +K QL+ +    L + +    
Sbjct: 33  QESRLNSVSSTQGDMMQKMPGESLSRAGAKAAGESSKYKIKKQLSEQDLQQLRLKIN--- 89

Query: 121 SLGRARSVVHDL 132
             GR R  +HDL
Sbjct: 90  --GRERKRMHDL 99


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 32.0 bits (71), Expect = 0.61
 Identities = 37/148 (25%), Positives = 59/148 (39%), Gaps = 21/148 (14%)

Query: 107  KRRPSLTVAVELVSSLGRARSVVHDLPVRVLPRRVWRDCLPPSLRASDASIRLPRWRTLR 166
            KR   + +  E +  L + RSV+  LP+ V  R                +++  + R L 
Sbjct: 1467 KRNQEVDLQQEQIQELEKCRSVLEHLPMAVQERE------------QKLTVQREQIRELE 1514

Query: 167  SIVERMANVGSHVLVEANLSGRMTLSIETEVVSIQSYFKNLGNPPQSAVGVPENRDLESM 226
               E   NV  H L+E     +M   IE++   +Q   K L      A+ + EN      
Sbjct: 1515 KDRETQRNVLEHQLLELEKKDQM---IESQRGQVQDLKKQLVTLECLALELEENHHKMEC 1571

Query: 227  VQVRVDNRKLLQFLEGQQIHPTTALCNI 254
             Q      KL++ LEGQ+     AL ++
Sbjct: 1572 QQ------KLIKELEGQRETQRVALTHL 1593


>gi|4504831 potassium voltage-gated channel, subfamily H, member 1
           isoform 2 [Homo sapiens]
          Length = 962

 Score = 31.2 bits (69), Expect = 1.0
 Identities = 29/141 (20%), Positives = 59/141 (41%), Gaps = 11/141 (7%)

Query: 36  PDSLCFGPAGSGG-LHEARLWCEVRQGAFQQFRMEGVSEDLDEIHLELTAEHLSRAARSA 94
           P S C GP G GG   + + W   +          G SED +++    + E L    +++
Sbjct: 790 PGSECLGPKGGGGDCAKRKSWARFKDAC-------GKSEDWNKVSKAESMETLPERTKAS 842

Query: 95  AGASSLKLQLTHKRRPSLTVAVELVSSLGRARSVVHDLPVRVLPRRVWRDCLPPSLRASD 154
             A+   L+ T      +T +   + ++G ARS     P+    +  +      +L+A+ 
Sbjct: 843 GEAT---LKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATV 899

Query: 155 ASIRLPRWRTLRSIVERMANV 175
             +R      ++++  +M N+
Sbjct: 900 LEVRHELKEDIKALNAKMTNI 920


>gi|27437001 potassium voltage-gated channel, subfamily H, member 1
           isoform 1 [Homo sapiens]
          Length = 989

 Score = 31.2 bits (69), Expect = 1.0
 Identities = 29/141 (20%), Positives = 59/141 (41%), Gaps = 11/141 (7%)

Query: 36  PDSLCFGPAGSGG-LHEARLWCEVRQGAFQQFRMEGVSEDLDEIHLELTAEHLSRAARSA 94
           P S C GP G GG   + + W   +          G SED +++    + E L    +++
Sbjct: 817 PGSECLGPKGGGGDCAKRKSWARFKDAC-------GKSEDWNKVSKAESMETLPERTKAS 869

Query: 95  AGASSLKLQLTHKRRPSLTVAVELVSSLGRARSVVHDLPVRVLPRRVWRDCLPPSLRASD 154
             A+   L+ T      +T +   + ++G ARS     P+    +  +      +L+A+ 
Sbjct: 870 GEAT---LKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATV 926

Query: 155 ASIRLPRWRTLRSIVERMANV 175
             +R      ++++  +M N+
Sbjct: 927 LEVRHELKEDIKALNAKMTNI 947


>gi|47157315 Janus kinase 3 [Homo sapiens]
          Length = 1124

 Score = 30.4 bits (67), Expect = 1.8
 Identities = 30/104 (28%), Positives = 49/104 (47%), Gaps = 5/104 (4%)

Query: 70  GVSEDLDEIHLELTA-EHLSRAARSAAGASSLKLQLTHKRRPS-LTVAVELVSSLGRARS 127
           G+ +DL    L+L   EHL    RS   +  L + L+ K +   L++AV  ++ + R ++
Sbjct: 119 GLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQA 178

Query: 128 VVHDLPVRVLPRRVWRDCLPPSLRASDASIRLPRWRTLRSIVER 171
                P  +L    ++ CLPPSLR     +     R +R  V R
Sbjct: 179 ---QRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRR 219


>gi|126723390 ankyrin repeat domain 24 [Homo sapiens]
          Length = 1146

 Score = 30.0 bits (66), Expect = 2.3
 Identities = 14/43 (32%), Positives = 27/43 (62%), Gaps = 1/43 (2%)

Query: 205 KNLGNPPQSAVGVPENRDL-ESMVQVRVDNRKLLQFLEGQQIH 246
           K    PP +++ +P++RD  E +V++R +  +LLQ + G + H
Sbjct: 304 KRKAPPPPASIPMPDDRDAYEEIVRLRQERGRLLQKIRGLEQH 346


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 28.9 bits (63), Expect = 5.2
 Identities = 38/164 (23%), Positives = 66/164 (40%), Gaps = 40/164 (24%)

Query: 91   ARSAAGASSLKLQLTHKRRPSLTVAVELVSSLGRARSVVHDLPVRVLPR-------RVWR 143
            A + AG+ + K ++T K +P++  A +  +  GR   V     +RV+ +       +V  
Sbjct: 8420 ASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGG 8479

Query: 144  DCLPPSLRASDASIRLPRWRTLRSIVERMANVGSHVLV-----EANLSGRMTLSIETEVV 198
            D +P      +      +WR L        N G  V +     EA L  R T   ++ + 
Sbjct: 8480 DPIP------NVKWTKGKWRQL--------NQGGRVFIHQKGDEAKLEIRDTTKTDSGLY 8525

Query: 199  SIQSYFKNLGNPPQSAVGVPENRDLESMVQVRVDNRKLLQFLEG 242
                            V   E+ ++ES V ++VD RK  + +EG
Sbjct: 8526 R--------------CVAFNEHGEIESNVNLQVDERKKQEKIEG 8555


>gi|118197272 ATG2 autophagy related 2 homolog B [Homo sapiens]
          Length = 2078

 Score = 28.1 bits (61), Expect = 8.8
 Identities = 36/142 (25%), Positives = 57/142 (40%), Gaps = 9/142 (6%)

Query: 8    TGKGCLELFIHVSGTVARLAKVCVLRVRPDSLCFGPAGSGGLHEARLW---CEVRQGAFQ 64
            T    LEL   +  T+   A+     V P +L   P  +      RL     ++R+G  +
Sbjct: 1936 TAMAALELTNRMVQTIQAAAETAYDMVSPGTLSIEPKKTKRFPHHRLAHQPVDLREGVAK 1995

Query: 65   QFRM--EGVSEDLDEIHLELTAEHLSRAARSAAGASSLKLQLTHKRRPSLTVAVELVSS- 121
             + +  EG+++    I+     EH SR    A G   +  Q+       L VA E  S+ 
Sbjct: 1996 AYSVVKEGITDTAQTIYETAAREHESRGVTGAVG--EVLRQIPPAVVKPLIVATEATSNV 2053

Query: 122  LGRARSVVHDLPVRVLPRRVWR 143
            LG  R+ +    VR    + WR
Sbjct: 2054 LGGMRNQIRP-DVRQDESQKWR 2074


>gi|51479173 dynein, axonemal, heavy chain 11 [Homo sapiens]
          Length = 4523

 Score = 28.1 bits (61), Expect = 8.8
 Identities = 36/146 (24%), Positives = 60/146 (41%), Gaps = 10/146 (6%)

Query: 107  KRRPSLT---VAVELVSSL---GRARSVVHDLPVRVLPRRVWRDCLPPSLRASDASIRLP 160
            K  PSL    + VE +  +   G  ++++HDL   +   +     L P+       I LP
Sbjct: 896  KANPSLDTWKIYVEFIDDIVVEGFFQAIMHDLDFFL---KNTEKQLKPAPFFQAQMILLP 952

Query: 161  RWRTLRSIVERMANVGSHVLVEANLSGRMTLSIETEVVSIQSYFKNLGNPPQSAVGVPEN 220
                 +  ++R A  G + LVE  L     +S +   ++     KN  N   + +G+ E 
Sbjct: 953  PEIVFKPSLDREAGDGFYDLVEEMLCNSFRMSAQMNRIATHLEIKNYQNDMDNMLGLAEV 1012

Query: 221  RDLESMVQVRVDNRKLLQFLEGQQIH 246
            R  E M +V     K+L F    + H
Sbjct: 1013 RQ-EIMNRVVNVINKVLDFRNTLETH 1037


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.135    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,747,371
Number of Sequences: 37866
Number of extensions: 387218
Number of successful extensions: 914
Number of sequences better than 10.0: 11
Number of HSP's better than 10.0 without gapping: 2
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 910
Number of HSP's gapped (non-prelim): 12
length of query: 278
length of database: 18,247,518
effective HSP length: 101
effective length of query: 177
effective length of database: 14,423,052
effective search space: 2552880204
effective search space used: 2552880204
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.