Search of human proteins with 30795248

Search of human proteins with 30795248

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|30795248 autophagy-related cysteine endopeptidase 2 isoform
b [Homo sapiens]
         (336 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|30795248 autophagy-related cysteine endopeptidase 2 isoform b...   700   0.0  
gi|30795252 autophagy-related cysteine endopeptidase 2 isoform a...   561   e-160
gi|47132611 APG4 autophagy 4 homolog B isoform a [Homo sapiens]       300   2e-81
gi|30410798 APG4 autophagy 4 homolog B isoform b [Homo sapiens]       290   2e-78
gi|27903825 APG4 autophagy 4 homolog D [Homo sapiens]                 142   3e-34
gi|30410846 APG4 autophagy 4 homolog C isoform 8 [Homo sapiens]       133   2e-31
gi|30410844 APG4 autophagy 4 homolog C isoform 7 [Homo sapiens]       133   2e-31
gi|146219843 Snf2-related CBP activator protein [Homo sapiens]         32   0.61 

>gi|30795248 autophagy-related cysteine endopeptidase 2 isoform b
           [Homo sapiens]
          Length = 336

 Score =  700 bits (1806), Expect = 0.0
 Identities = 336/336 (100%), Positives = 336/336 (100%)

Query: 1   MESVLSKYEDQITIFTDYLEEYPDTDELVWILGKQHLLKTEKSKLLSDISARLWFTYRRK 60
           MESVLSKYEDQITIFTDYLEEYPDTDELVWILGKQHLLKTEKSKLLSDISARLWFTYRRK
Sbjct: 1   MESVLSKYEDQITIFTDYLEEYPDTDELVWILGKQHLLKTEKSKLLSDISARLWFTYRRK 60

Query: 61  FSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWSWEKQKEQPKEYQRILQCFLD 120
           FSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWSWEKQKEQPKEYQRILQCFLD
Sbjct: 61  FSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWSWEKQKEQPKEYQRILQCFLD 120

Query: 121 RKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVLKKLALFDEWNSLAVYVSMDNTVVIE 180
           RKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVLKKLALFDEWNSLAVYVSMDNTVVIE
Sbjct: 121 RKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVLKKLALFDEWNSLAVYVSMDNTVVIE 180

Query: 181 DIKKMCRVLPLSADTAGDRPPDSLTASNQSDELIFLDPHTTQTFVDTEENGTVNDQTFHC 240
           DIKKMCRVLPLSADTAGDRPPDSLTASNQSDELIFLDPHTTQTFVDTEENGTVNDQTFHC
Sbjct: 181 DIKKMCRVLPLSADTAGDRPPDSLTASNQSDELIFLDPHTTQTFVDTEENGTVNDQTFHC 240

Query: 241 LQSPQRMNILNLDPSVALGFFCKEEKDFDNWCSLVQKEILKENLRMFELVQKHPSHWPPF 300
           LQSPQRMNILNLDPSVALGFFCKEEKDFDNWCSLVQKEILKENLRMFELVQKHPSHWPPF
Sbjct: 241 LQSPQRMNILNLDPSVALGFFCKEEKDFDNWCSLVQKEILKENLRMFELVQKHPSHWPPF 300

Query: 301 VPPAKPEVTTTGAEFIDSTEQLEEFDLEEDFEILSV 336
           VPPAKPEVTTTGAEFIDSTEQLEEFDLEEDFEILSV
Sbjct: 301 VPPAKPEVTTTGAEFIDSTEQLEEFDLEEDFEILSV 336


>gi|30795252 autophagy-related cysteine endopeptidase 2 isoform a
           [Homo sapiens]
          Length = 398

 Score =  561 bits (1446), Expect = e-160
 Identities = 295/401 (73%), Positives = 300/401 (74%), Gaps = 68/401 (16%)

Query: 1   MESVLSKYEDQITIFTDYLEEYPDTDELVWILGKQHLLKTEKSKLLSDISARLWFTYRRK 60
           MESVLSKYEDQITIFTDYLEEYPDTDELVWILGKQHLLKTEKSKLLSDISARLWFTYRRK
Sbjct: 1   MESVLSKYEDQITIFTDYLEEYPDTDELVWILGKQHLLKTEKSKLLSDISARLWFTYRRK 60

Query: 61  FSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWSWEKQKEQPKEYQRILQCFLD 120
           FSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWSWEKQKEQPKEYQRILQCFLD
Sbjct: 61  FSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWSWEKQKEQPKEYQRILQCFLD 120

Query: 121 RKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVLKKLALFDEWNSLAVYVSMDNTVVIE 180
           RKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVLKKLALFDEWNSLAVYVSMDNTVVIE
Sbjct: 121 RKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVLKKLALFDEWNSLAVYVSMDNTVVIE 180

Query: 181 DIKKMCRVLPLSADTAGDRPPDSLTASNQS----------DELIFLDPHTTQTFVDTEEN 230
           DIKKMCRVLPLSADTAGDRPPDSLTASNQS            L+ + P         + N
Sbjct: 181 DIKKMCRVLPLSADTAGDRPPDSLTASNQSKGTSAYCSAWKPLLLIVPLRLGI---NQIN 237

Query: 231 GTVNDQTFHCLQSPQRMNILN-------------------LDPSVALGFFCKEE------ 265
               D    C + PQ +  L                    LDP     F   EE      
Sbjct: 238 PVYVDAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDTEENGTVND 297

Query: 266 ------------------------------KDFDNWCSLVQKEILKENLRMFELVQKHPS 295
                                         KDFDNWCSLVQKEILKENLRMFELVQKHPS
Sbjct: 298 QTFHCLQSPQRMNILNLDPSVALGFFCKEEKDFDNWCSLVQKEILKENLRMFELVQKHPS 357

Query: 296 HWPPFVPPAKPEVTTTGAEFIDSTEQLEEFDLEEDFEILSV 336
           HWPPFVPPAKPEVTTTGAEFIDSTEQLEEFDLEEDFEILSV
Sbjct: 358 HWPPFVPPAKPEVTTTGAEFIDSTEQLEEFDLEEDFEILSV 398


>gi|47132611 APG4 autophagy 4 homolog B isoform a [Homo sapiens]
          Length = 393

 Score =  300 bits (767), Expect = 2e-81
 Identities = 168/387 (43%), Positives = 223/387 (57%), Gaps = 80/387 (20%)

Query: 20  EEYPDTDELVWILGKQHLLKTEKSKLLSDISARLWFTYRRKFSPIGGTGPSSDAGWGCML 79
           E++P+T E VWILG+++ + TEK ++LSD+++RLWFTYR+ F  IGGTGP+SD GWGCML
Sbjct: 17  EDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCML 76

Query: 80  RCGQMMLAQALICRHLGRDWSWEKQKEQPKEYQRILQCFLDRKDCCYSIHQMAQMGVGEG 139
           RCGQM+ AQAL+CRHLGRDW W ++K QP  Y  +L  F+DRKD  YSIHQ+AQMGVGEG
Sbjct: 77  RCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEG 136

Query: 140 KSIGEWFGPNTVAQVLKKLALFDEWNSLAVYVSMDNTVVIEDIKKMCR---------VLP 190
           KSIG+W+GPNTVAQVLKKLA+FD W+SLAV+++MDNTVV+E+I+++CR           P
Sbjct: 137 KSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSVPCAGATAFP 196

Query: 191 LSADTAGDRPPDSLTASNQSD---ELIFLDPHTTQTFVDTEENGTVNDQTFHCLQSPQRM 247
             +D   +  P     +N+      L+ L P        T+ N    +   HC   PQ +
Sbjct: 197 ADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGL---TDINEAYVETLKHCFMMPQSL 253

Query: 248 NILN-------------------LDP---------------------------------- 254
            ++                    LDP                                  
Sbjct: 254 GVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFHCQHPPCRMSIAEL 313

Query: 255 --SVALGFFCKEEKDFDNWCSLVQK-EILKENLRMFELVQKHPSHWPPFVPPAKPEVTTT 311
             S+A+GFFCK E DF++WC  V+K  +L   L MFELV+  PSH       A P+V   
Sbjct: 314 DPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHL------ACPDVLNL 367

Query: 312 GAEFIDSTEQLEEF--DLEEDFEILSV 336
             +  D  E+LE F    +EDFEILS+
Sbjct: 368 SLDSSD-VERLERFFDSEDEDFEILSL 393


>gi|30410798 APG4 autophagy 4 homolog B isoform b [Homo sapiens]
          Length = 380

 Score =  290 bits (741), Expect = 2e-78
 Identities = 153/345 (44%), Positives = 203/345 (58%), Gaps = 71/345 (20%)

Query: 20  EEYPDTDELVWILGKQHLLKTEKSKLLSDISARLWFTYRRKFSPIGGTGPSSDAGWGCML 79
           E++P+T E VWILG+++ + TEK ++LSD+++RLWFTYR+ F  IGGTGP+SD GWGCML
Sbjct: 17  EDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCML 76

Query: 80  RCGQMMLAQALICRHLGRDWSWEKQKEQPKEYQRILQCFLDRKDCCYSIHQMAQMGVGEG 139
           RCGQM+ AQAL+CRHLGRDW W ++K QP  Y  +L  F+DRKD  YSIHQ+AQMGVGEG
Sbjct: 77  RCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEG 136

Query: 140 KSIGEWFGPNTVAQVLKKLALFDEWNSLAVYVSMDNTVVIEDIKKMCR---------VLP 190
           KSIG+W+GPNTVAQVLKKLA+FD W+SLAV+++MDNTVV+E+I+++CR           P
Sbjct: 137 KSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSVPCAGATAFP 196

Query: 191 LSADTAGDRPPDSLTASNQSD---ELIFLDPHTTQTFVDTEENGTVNDQTFHCLQSPQRM 247
             +D   +  P     +N+      L+ L P        T+ N    +   HC   PQ +
Sbjct: 197 ADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGL---TDINEAYVETLKHCFMMPQSL 253

Query: 248 NILN-------------------LDP---------------------------------- 254
            ++                    LDP                                  
Sbjct: 254 GVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFHCQHPPCRMSIAEL 313

Query: 255 --SVALGFFCKEEKDFDNWCSLVQK-EILKENLRMFELVQKHPSH 296
             S+A+GFFCK E DF++WC  V+K  +L   L MFELV+  PSH
Sbjct: 314 DPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSH 358


>gi|27903825 APG4 autophagy 4 homolog D [Homo sapiens]
          Length = 474

 Score =  142 bits (359), Expect = 3e-34
 Identities = 96/322 (29%), Positives = 142/322 (44%), Gaps = 78/322 (24%)

Query: 48  DISARLWFTYRRKFSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWSWEK---- 103
           D  +RLW TYRR F P+ G   +SD GWGCMLR GQMMLAQ L+   L RDW+W +    
Sbjct: 115 DFVSRLWLTYRRDFPPLPGGCLTSDCGWGCMLRSGQMMLAQGLLLHFLPRDWTWAEGMGL 174

Query: 104 ------------------------------QKEQPKEYQRILQCFLDRKDCCYSIHQMAQ 133
                                         + EQ + +++I+  F D     + +H++ +
Sbjct: 175 GPPELSGSASPSRYHGPARWMPPRWAQGAPELEQERRHRQIVSWFADHPRAPFGLHRLVE 234

Query: 134 MGVGEGKSIGEWFGPNTVAQVLKK-LALFDEWNSLAVYVSMDNTVVIEDI---------- 182
           +G   GK  G+W+GP+ VA +L+K +    +   L VYVS D TV   D+          
Sbjct: 235 LGQSSGKKAGDWYGPSLVAHILRKAVESCSDVTRLVVYVSQDCTVYKADVARLVARPDPT 294

Query: 183 ---KKMCRVLP-----------------------LSADTAGDRPPDSL-TASNQSDELIF 215
              K +  ++P                       L     G +P  SL     Q D L++
Sbjct: 295 AEWKSVVILVPVRLGGETLNPVYVPCVKELLRCELCLGIMGGKPRHSLYFIGYQDDFLLY 354

Query: 216 LDPHTTQTFVDTEENGTVNDQTFHCLQSPQRMNILNLDPSVALGFFCKEEKDFDNWCS-- 273
           LDPH  Q  VD  +      ++FHC  SP++M    +DPS  +GF+  + K+F+  CS  
Sbjct: 355 LDPHYCQPTVDVSQ-ADFPLESFHC-TSPRKMAFAKMDPSCTVGFYAGDRKEFETLCSEL 412

Query: 274 --LVQKEILKENLRMFELVQKH 293
             ++      E   MF L + H
Sbjct: 413 TRVLSSSSATERYPMFTLAEGH 434


>gi|30410846 APG4 autophagy 4 homolog C isoform 8 [Homo sapiens]
          Length = 458

 Score =  133 bits (335), Expect = 2e-31
 Identities = 108/399 (27%), Positives = 165/399 (41%), Gaps = 115/399 (28%)

Query: 34  KQHLLKTEKSKLLSDISARLWFTYRRKFSPIGGTGPSSDAGWGCMLRCGQMMLAQALICR 93
           + H++     +   D  +R+W TYR +F  I G+  ++D GWGC LR GQM+LAQ LI  
Sbjct: 68  EDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLLAQGLILH 127

Query: 94  HLGRDWSW--------------------------------EKQKEQP----KE------- 110
            LGR W+W                                E++ + P    KE       
Sbjct: 128 FLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKETIGKYSD 187

Query: 111 ---------YQRILQCFLDRKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVLKKL--- 158
                    +++I+  F D     + +HQ+ + G   GK  G+W+GP  VA +L+K    
Sbjct: 188 DHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHILRKAVEE 247

Query: 159 ALFDEWNSLAVYVSMDNTVVIEDI--KKMCRVLPLSAD---------------------- 194
           A   +   + +YV+ D TV   D+  K+   +   +AD                      
Sbjct: 248 ARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGERTNTDYL 307

Query: 195 --------------TAGDRPPDS-LTASNQSDELIFLDPHTTQTFVDTEENGTVND---Q 236
                           G +P  S   A  Q D LI++DPH  Q+FVD     ++ D   +
Sbjct: 308 EFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDV----SIKDFPLE 363

Query: 237 TFHCLQSPQRMNILNLDPSVALGFFCKEEKDFDNWCSLVQKEI---LKENLRMFELVQKH 293
           TFHC  SP++M+   +DPS  +GF+C+  +DF      + K +    KE   +F  V  H
Sbjct: 364 TFHC-PSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVNGH 422

Query: 294 PSHWPPFVPPAKPEVTTTGAEFI---DSTEQLEEFDLEE 329
              +  F        TTT  E +   D  +QL+ F  EE
Sbjct: 423 SRDY-DFTS------TTTNEEDLFSEDEKKQLKRFSTEE 454


>gi|30410844 APG4 autophagy 4 homolog C isoform 7 [Homo sapiens]
          Length = 458

 Score =  133 bits (335), Expect = 2e-31
 Identities = 108/399 (27%), Positives = 165/399 (41%), Gaps = 115/399 (28%)

Query: 34  KQHLLKTEKSKLLSDISARLWFTYRRKFSPIGGTGPSSDAGWGCMLRCGQMMLAQALICR 93
           + H++     +   D  +R+W TYR +F  I G+  ++D GWGC LR GQM+LAQ LI  
Sbjct: 68  EDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLLAQGLILH 127

Query: 94  HLGRDWSW--------------------------------EKQKEQP----KE------- 110
            LGR W+W                                E++ + P    KE       
Sbjct: 128 FLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKETIGKYSD 187

Query: 111 ---------YQRILQCFLDRKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVLKKL--- 158
                    +++I+  F D     + +HQ+ + G   GK  G+W+GP  VA +L+K    
Sbjct: 188 DHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHILRKAVEE 247

Query: 159 ALFDEWNSLAVYVSMDNTVVIEDI--KKMCRVLPLSAD---------------------- 194
           A   +   + +YV+ D TV   D+  K+   +   +AD                      
Sbjct: 248 ARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGERTNTDYL 307

Query: 195 --------------TAGDRPPDS-LTASNQSDELIFLDPHTTQTFVDTEENGTVND---Q 236
                           G +P  S   A  Q D LI++DPH  Q+FVD     ++ D   +
Sbjct: 308 EFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDV----SIKDFPLE 363

Query: 237 TFHCLQSPQRMNILNLDPSVALGFFCKEEKDFDNWCSLVQKEI---LKENLRMFELVQKH 293
           TFHC  SP++M+   +DPS  +GF+C+  +DF      + K +    KE   +F  V  H
Sbjct: 364 TFHC-PSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVNGH 422

Query: 294 PSHWPPFVPPAKPEVTTTGAEFI---DSTEQLEEFDLEE 329
              +  F        TTT  E +   D  +QL+ F  EE
Sbjct: 423 SRDY-DFTS------TTTNEEDLFSEDEKKQLKRFSTEE 454


>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
          Length = 3230

 Score = 32.3 bits (72), Expect = 0.61
 Identities = 17/63 (26%), Positives = 31/63 (49%), Gaps = 4/63 (6%)

Query: 104 QKEQPKEYQRILQCFLDRKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVLKKLA---- 159
           +K+ PK+Y+ +++C L ++  C     MAQ    E  + G +     +   L+K+     
Sbjct: 846 EKQMPKKYEHVIRCRLSKRQRCLYDDFMAQTTTKETLATGHFMSVINILMQLRKVCNHPN 905

Query: 160 LFD 162
           LFD
Sbjct: 906 LFD 908


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.422 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,911,845
Number of Sequences: 37866
Number of extensions: 622582
Number of successful extensions: 1671
Number of sequences better than 10.0: 8
Number of HSP's better than 10.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 1649
Number of HSP's gapped (non-prelim): 17
length of query: 336
length of database: 18,247,518
effective HSP length: 103
effective length of query: 233
effective length of database: 14,347,320
effective search space: 3342925560
effective search space used: 3342925560
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.