Search of human proteins with 28178819

Search of human proteins with 28178819

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|28178819 isocitrate dehydrogenase 3, beta subunit isoform c
[Homo sapiens]
         (233 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|28178819 isocitrate dehydrogenase 3, beta subunit isoform c [...   469   e-133
gi|28178821 isocitrate dehydrogenase 3, beta subunit isoform a p...   416   e-117
gi|28178816 isocitrate dehydrogenase 3, beta subunit isoform b p...   387   e-108
gi|4758582 isocitrate dehydrogenase 3 (NAD+) gamma isoform a pre...   228   3e-60
gi|28178838 isocitrate dehydrogenase 3 (NAD+) gamma isoform b pr...   211   4e-55
gi|5031777 isocitrate dehydrogenase 3 (NAD+) alpha precursor [Ho...   189   2e-48
gi|139394648 DNA polymerase theta [Homo sapiens]                       30   1.8  
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]                     28   5.2  
gi|37574606 zinc finger protein 198 [Homo sapiens]                     28   5.2  
gi|4508011 zinc finger protein 198 [Homo sapiens]                      28   5.2  
gi|218083730 zinc finger protein 237 isoform 3 [Homo sapiens]          28   5.2  
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]                     28   8.8  
gi|50811889 centrosomal protein 192kDa [Homo sapiens]                  28   8.8  

>gi|28178819 isocitrate dehydrogenase 3, beta subunit isoform c
           [Homo sapiens]
          Length = 233

 Score =  469 bits (1208), Expect = e-133
 Identities = 233/233 (100%), Positives = 233/233 (100%)

Query: 1   MKMGERWSSLFPFPVSPSCCFLLTQSARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGK 60
           MKMGERWSSLFPFPVSPSCCFLLTQSARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGK
Sbjct: 1   MKMGERWSSLFPFPVSPSCCFLLTQSARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGK 60

Query: 61  VTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNL 120
           VTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNL
Sbjct: 61  VTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNL 120

Query: 121 YGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNM 180
           YGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNM
Sbjct: 121 YGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNM 180

Query: 181 LRHLNLEYHSSMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHLQTKGS 233
           LRHLNLEYHSSMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHLQTKGS
Sbjct: 181 LRHLNLEYHSSMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHLQTKGS 233


>gi|28178821 isocitrate dehydrogenase 3, beta subunit isoform a
           precursor [Homo sapiens]
          Length = 385

 Score =  416 bits (1069), Expect = e-117
 Identities = 208/209 (99%), Positives = 209/209 (100%)

Query: 25  QSARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEV 84
           +SARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEV
Sbjct: 177 ESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEV 236

Query: 85  AELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESY 144
           AELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESY
Sbjct: 237 AELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESY 296

Query: 145 SAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVG 204
           SAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVG
Sbjct: 297 SAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVG 356

Query: 205 KVRTRDMGGYSTTTDFIKSVIGHLQTKGS 233
           KVRTRDMGGYSTTTDFIKSVIGHLQTKGS
Sbjct: 357 KVRTRDMGGYSTTTDFIKSVIGHLQTKGS 385


>gi|28178816 isocitrate dehydrogenase 3, beta subunit isoform b
           precursor [Homo sapiens]
          Length = 383

 Score =  387 bits (994), Expect = e-108
 Identities = 194/204 (95%), Positives = 198/204 (97%)

Query: 25  QSARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEV 84
           +SARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEV
Sbjct: 177 ESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEV 236

Query: 85  AELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESY 144
           AELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESY
Sbjct: 237 AELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESY 296

Query: 145 SAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVG 204
           SAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVG
Sbjct: 297 SAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVG 356

Query: 205 KVRTRDMGGYSTTTDFIKSVIGHL 228
           KVRT DMGGY+T  DF ++VI  L
Sbjct: 357 KVRTSDMGGYATCHDFTEAVIAAL 380


>gi|4758582 isocitrate dehydrogenase 3 (NAD+) gamma isoform a
           precursor [Homo sapiens]
          Length = 393

 Score =  228 bits (582), Expect = 3e-60
 Identities = 116/205 (56%), Positives = 146/205 (71%)

Query: 25  QSARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEV 84
           +S  GV+E LKI+T+AKS RIA++AF  A + GR KVTAVHKANIMKLGDGLFLQCC EV
Sbjct: 180 ESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREV 239

Query: 85  AELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESY 144
           A  YP+I FE MI+DN  MQLV  P QFDV+VMPNLYGNI++N+ AGLVGG G+V G +Y
Sbjct: 240 AARYPQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANY 299

Query: 145 SAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVG 204
              YAVFET  R+       +NIANPTA LL++  ML HL L  +++ I  AV   +   
Sbjct: 300 GHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSIRKAVLASMDNE 359

Query: 205 KVRTRDMGGYSTTTDFIKSVIGHLQ 229
            + T D+GG  TT++ I+ VI H++
Sbjct: 360 NMHTPDIGGQGTTSEAIQDVIRHIR 384


>gi|28178838 isocitrate dehydrogenase 3 (NAD+) gamma isoform b
           precursor [Homo sapiens]
          Length = 380

 Score =  211 bits (537), Expect = 4e-55
 Identities = 106/173 (61%), Positives = 128/173 (73%)

Query: 25  QSARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEV 84
           +S  GV+E LKI+T+AKS RIA++AF  A + GR KVTAVHKANIMKLGDGLFLQCC EV
Sbjct: 180 ESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREV 239

Query: 85  AELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESY 144
           A  YP+I FE MI+DN  MQLV  P QFDV+VMPNLYGNI++N+ AGLVGG G+V G +Y
Sbjct: 240 AARYPQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANY 299

Query: 145 SAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAV 197
              YAVFET  R+       +NIANPTA LL++  ML HL L  +++ I  AV
Sbjct: 300 GHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSIRKAV 352


>gi|5031777 isocitrate dehydrogenase 3 (NAD+) alpha precursor [Homo
           sapiens]
          Length = 366

 Score =  189 bits (479), Expect = 2e-48
 Identities = 98/197 (49%), Positives = 132/197 (67%), Gaps = 2/197 (1%)

Query: 29  GVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELY 88
           GV++ +K++T   S+RIA+FAF+YA    R  VTAVHKANIM++ DGLFLQ C EVAE  
Sbjct: 163 GVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAESC 222

Query: 89  PKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAE- 147
             IKF  M +D  C+ +VQ+P QFDVLVMPNLYG+I+ +L AGL+GG GV P  +  A  
Sbjct: 223 KDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANG 282

Query: 148 YAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVR 207
            A+FE+          G+++ANPTA+LLSA  MLRH+ L  H++ I  A    IK GK  
Sbjct: 283 VAIFES-VHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAARIEAACFATIKDGKSL 341

Query: 208 TRDMGGYSTTTDFIKSV 224
           T+D+GG +  +DF + +
Sbjct: 342 TKDLGGNAKCSDFTEEI 358


>gi|139394648 DNA polymerase theta [Homo sapiens]
          Length = 2590

 Score = 30.0 bits (66), Expect = 1.8
 Identities = 17/65 (26%), Positives = 32/65 (49%), Gaps = 2/65 (3%)

Query: 11   FPFPVSPSCCFLLTQSARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIM 70
            FP  +  +C + +T +    +E   IVT ++S+ +   A    ++KGRG      K N +
Sbjct: 1114 FPLQIKQNCSWNITLTNDNFVE--HIVTGSQSKNVTCQATSVVSEKGRGVAVEAEKINEV 1171

Query: 71   KLGDG 75
             + +G
Sbjct: 1172 LIQNG 1176


>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
          Length = 1263

 Score = 28.5 bits (62), Expect = 5.2
 Identities = 19/93 (20%), Positives = 41/93 (44%), Gaps = 1/93 (1%)

Query: 41  KSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDN 100
           KS++  +       KK + K  + H+ +    GD    Q  ++V++    + FE M++D 
Sbjct: 35  KSKKFLERFTSMRIKKEKEKPNSAHRNSSASYGDDPTAQSLQDVSDEQVLVLFEQMLLDM 94

Query: 101 CCMQLVQNPY-QFDVLVMPNLYGNIIDNLAAGL 132
              +  Q P  + D+++   +    +    AG+
Sbjct: 95  NLNEEKQQPLREKDIIIKREMVSQYLYTSKAGM 127


>gi|37574606 zinc finger protein 198 [Homo sapiens]
          Length = 1377

 Score = 28.5 bits (62), Expect = 5.2
 Identities = 16/70 (22%), Positives = 30/70 (42%), Gaps = 7/70 (10%)

Query: 44  RIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPK--IKFETMIIDN- 100
           ++ +   + + K    K+ + H  N  ++ +GL + CCE+  E  P        ++ID  
Sbjct: 430 KLTEIRHEVSFKNMTHKLCSDHCFNRYRMANGLIMNCCEQCGEYLPSKGAGNNVLVIDGQ 489

Query: 101 ----CCMQLV 106
               CC   V
Sbjct: 490 QKRFCCQSCV 499


>gi|4508011 zinc finger protein 198 [Homo sapiens]
          Length = 1377

 Score = 28.5 bits (62), Expect = 5.2
 Identities = 16/70 (22%), Positives = 30/70 (42%), Gaps = 7/70 (10%)

Query: 44  RIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPK--IKFETMIIDN- 100
           ++ +   + + K    K+ + H  N  ++ +GL + CCE+  E  P        ++ID  
Sbjct: 430 KLTEIRHEVSFKNMTHKLCSDHCFNRYRMANGLIMNCCEQCGEYLPSKGAGNNVLVIDGQ 489

Query: 101 ----CCMQLV 106
               CC   V
Sbjct: 490 QKRFCCQSCV 499


>gi|218083730 zinc finger protein 237 isoform 3 [Homo sapiens]
          Length = 669

 Score = 28.5 bits (62), Expect = 5.2
 Identities = 12/46 (26%), Positives = 22/46 (47%)

Query: 44  RIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYP 89
           ++A+   + +      K+ + H  N  +L +GL + CCE   E  P
Sbjct: 343 KLAEIRHEVSVNNVTHKLCSNHCFNKYRLANGLIMNCCEHCGEYMP 388


>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
          Length = 1272

 Score = 27.7 bits (60), Expect = 8.8
 Identities = 17/79 (21%), Positives = 36/79 (45%), Gaps = 1/79 (1%)

Query: 55  KKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPY-QFD 113
           KK + K  + H+ +    GD    Q  ++V++    + FE M++D    +  Q P  + D
Sbjct: 58  KKEKEKPNSAHRNSSASYGDDPTAQSLQDVSDEQVLVLFEQMLLDMNLNEEKQQPLREKD 117

Query: 114 VLVMPNLYGNIIDNLAAGL 132
           +++   +    +    AG+
Sbjct: 118 IIIKREMVSQYLYTSKAGM 136


>gi|50811889 centrosomal protein 192kDa [Homo sapiens]
          Length = 1941

 Score = 27.7 bits (60), Expect = 8.8
 Identities = 12/28 (42%), Positives = 18/28 (64%)

Query: 137  GVVPGESYSAEYAVFETGARHPFAQAVG 164
            G+VPG+     ++V  TG+R  F +AVG
Sbjct: 1306 GLVPGKESKIVFSVRNTGSRAAFVKAVG 1333


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.136    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,919,922
Number of Sequences: 37866
Number of extensions: 292273
Number of successful extensions: 577
Number of sequences better than 10.0: 13
Number of HSP's better than 10.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 567
Number of HSP's gapped (non-prelim): 13
length of query: 233
length of database: 18,247,518
effective HSP length: 99
effective length of query: 134
effective length of database: 14,498,784
effective search space: 1942837056
effective search space used: 1942837056
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.