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Search of human proteins with 27734755
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27734755 F-box and leucine-rich repeat protein 20 [Homo
sapiens]
(436 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens] 893 0.0
gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens] 709 0.0
gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens] 171 9e-43
gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2 ... 160 2e-39
gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1 ... 160 2e-39
gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens] 148 8e-36
gi|24025682 F-box and leucine-rich repeat protein 16 [Homo sapiens] 123 4e-28
gi|16306588 F-box and leucine-rich repeat protein 4 [Homo sapiens] 112 7e-25
gi|164663798 antagonist of mitotic exit network 1 homolog [Homo ... 92 9e-19
gi|254039600 F-box and leucine-rich repeat protein 17 [Homo sapi... 90 4e-18
gi|190194416 F-box and leucine-rich repeat protein 15 [Homo sapi... 89 8e-18
gi|16306595 S-phase kinase-associated protein 2 isoform 1 [Homo ... 81 2e-15
gi|14249170 S-phase kinase-associated protein 2 isoform 2 [Homo ... 77 3e-14
gi|51873034 F-box and leucine-rich repeat protein 9 [Homo sapiens] 71 2e-12
gi|16306591 F-box and leucine-rich repeat protein 9 [Homo sapiens] 71 2e-12
gi|157168349 F-box and leucine-rich repeat protein 19 [Homo sapi... 69 8e-12
gi|54112382 F-box and leucine-rich repeat protein 10 isoform a [... 68 2e-11
gi|54112380 F-box and leucine-rich repeat protein 10 isoform b [... 68 2e-11
gi|16306576 F-box and leucine-rich repeat protein 6 isoform 1 [H... 65 1e-10
gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens] 64 3e-10
gi|8923179 F-box and leucine-rich repeat protein 12 [Homo sapiens] 62 1e-09
gi|61742136 F-box and leucine-rich repeat protein 6 isoform 2 [H... 60 4e-09
gi|16306574 F-box and leucine-rich repeat protein 5 isoform 2 [H... 57 3e-08
gi|16306572 F-box and leucine-rich repeat protein 5 isoform 1 [H... 57 3e-08
gi|122937219 F-box protein 41 [Homo sapiens] 51 2e-06
gi|30795121 F-box and WD repeat domain containing 8 isoform 2 [H... 45 1e-04
gi|30795123 F-box and WD repeat domain containing 8 isoform 1 [H... 45 1e-04
gi|30089926 F-box only protein 11 isoform 1 [Homo sapiens] 42 0.001
gi|30089924 F-box only protein 11 isoform 2 [Homo sapiens] 42 0.001
gi|30089922 F-box only protein 11 isoform 3 [Homo sapiens] 42 0.001
>gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens]
Length = 436
Score = 893 bits (2308), Expect = 0.0
Identities = 436/436 (100%), Positives = 436/436 (100%)
Query: 1 MRRDVNGVTKSRFEMFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLAL 60
MRRDVNGVTKSRFEMFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLAL
Sbjct: 1 MRRDVNGVTKSRFEMFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLAL 60
Query: 61 DGSNWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIE 120
DGSNWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIE
Sbjct: 61 DGSNWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIE 120
Query: 121 VLNLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCD 180
VLNLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCD
Sbjct: 121 VLNLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCD 180
Query: 181 QVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLI 240
QVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLI
Sbjct: 181 QVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLI 240
Query: 241 TICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHE 300
TICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHE
Sbjct: 241 TICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHE 300
Query: 301 LEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIE 360
LEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIE
Sbjct: 301 LEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIE 360
Query: 361 LDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPP 420
LDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPP
Sbjct: 361 LDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPP 420
Query: 421 SVGGSRQRFCRCCIIL 436
SVGGSRQRFCRCCIIL
Sbjct: 421 SVGGSRQRFCRCCIIL 436
>gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens]
Length = 423
Score = 709 bits (1830), Expect = 0.0
Identities = 330/422 (78%), Positives = 377/422 (89%)
Query: 15 MFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQ 74
+FSN+DE +INKKLPKELLLRIFSFLD+VTLCRCAQ+S+AWN+LALDGSNWQRIDLF+FQ
Sbjct: 2 VFSNNDEGLINKKLPKELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRIDLFNFQ 61
Query: 75 RDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDAT 134
D+EGRVVENISKRCGGFLRKLSLRGC+GVGD++L+TFAQNCRNIE LNLNGCTK TD+T
Sbjct: 62 IDVEGRVVENISKRCGGFLRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDST 121
Query: 135 CTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGC 194
C SLS+FCSKL+HLDL SC SITN SLK +SEGC LE LN+SWCDQ+TKDGI+ALVRGC
Sbjct: 122 CYSLSRFCSKLKHLDLTSCVSITNSSLKGISEGCRNLEYLNLSWCDQITKDGIEALVRGC 181
Query: 195 GGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCA 254
GLKAL L+GCTQLEDEALK+I +C ELV+LNLQ+C +ITDEG++ ICRGCH+LQ+LC
Sbjct: 182 RGLKALLLRGCTQLEDEALKHIQNYCHELVSLNLQSCSRITDEGVVQICRGCHRLQALCL 241
Query: 255 SGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITD 314
SGCSN+TDA L ALG NCPRL+ILE ARCS LTD GFT LARNCHELEKMDLEEC+ ITD
Sbjct: 242 SGCSNLTDASLTALGLNCPRLQILEAARCSHLTDAGFTLLARNCHELEKMDLEECILITD 301
Query: 315 STLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEH 374
STLIQLSIHCP+LQ LSLSHCELITDDGI HL N C H++L V+ELDNC LITD +LEH
Sbjct: 302 STLIQLSIHCPKLQALSLSHCELITDDGILHLSNSTCGHERLRVLELDNCLLITDVALEH 361
Query: 375 LKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSRQRFCRCCI 434
L++C LER+ELYDCQQ+TRAGIKR+R LP++KVHAYFAPVTPP +V GS QR CRCC+
Sbjct: 362 LENCRGLERLELYDCQQVTRAGIKRMRAQLPHVKVHAYFAPVTPPTAVAGSGQRLCRCCV 421
Query: 435 IL 436
IL
Sbjct: 422 IL 423
>gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens]
Length = 491
Score = 171 bits (434), Expect = 9e-43
Identities = 108/370 (29%), Positives = 190/370 (51%), Gaps = 22/370 (5%)
Query: 27 KLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENIS 86
+LP +++IFSFL LCRCA+V R W LA D W+ I L +++ R ++ ++
Sbjct: 116 RLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVD-RALKVLT 174
Query: 87 KR-CGG------FLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLS 139
+R C L +++ GC + D L T AQ C + L ++GC ++ +
Sbjct: 175 RRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVV 234
Query: 140 KFCSKLRHLDLASCTSITNMSL--KALSEGCPL------LEQLNISWCDQVTKDGIQALV 191
C L HLD++ C+ +T +SL +A + PL + L+++ C + +G+ +
Sbjct: 235 SLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIA 294
Query: 192 RGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQS 251
C L L+L+ C +L DE L+Y+ +C + L++ C ++D GL I + +L+
Sbjct: 295 AHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRY 354
Query: 252 LCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQ 311
L + C +TD + + + C +LR L C +TD G LA+NC +L+ +D+ +C
Sbjct: 355 LSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPL 414
Query: 312 ITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDA- 370
++D+ L L+++C L+ LSL CE IT G++ + A L+ + + +C + +A
Sbjct: 415 VSDTGLECLALNCFNLKRLSLKSCESITGQGLQIV---AANCFDLQTLNVQDCEVSVEAL 471
Query: 371 --SLEHLKSC 378
H K C
Sbjct: 472 RFVKRHCKRC 481
Score = 107 bits (266), Expect = 3e-23
Identities = 68/250 (27%), Positives = 130/250 (52%), Gaps = 12/250 (4%)
Query: 168 CPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLN 227
C +LE + +S C ++T G+ + + C L+ L + GC + +EA+ + + CP L L+
Sbjct: 185 CLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLD 244
Query: 228 LQ-----TCLQITDEGLITICRGCHK---LQSLCASGCSNITDAILNALGQNCPRLRILE 279
+ TC+ +T E I + K ++ L + C + D L+ + +C +L L
Sbjct: 245 VSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLY 304
Query: 280 VARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELIT 339
+ RC +LTD G L C ++++ + +C ++D L +++ RL+ LS++HC +T
Sbjct: 305 LRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVT 364
Query: 340 DDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHL-KSCHSLERIELYDCQQITRAGIK 398
D GIR++ +L + C ITD +E+L K+C L+ +++ C ++ G++
Sbjct: 365 DVGIRYVAKYC---SKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLE 421
Query: 399 RLRTHLPNIK 408
L + N+K
Sbjct: 422 CLALNCFNLK 431
>gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2
[Homo sapiens]
Length = 690
Score = 160 bits (406), Expect = 2e-39
Identities = 109/373 (29%), Positives = 196/373 (52%), Gaps = 10/373 (2%)
Query: 28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISK 87
LP+ +L+IF +L + + C QV+ AW ++ S W ID + I + + + +
Sbjct: 158 LPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQ 217
Query: 88 RCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRH 147
R + +L+ RGCL + R+ + +CRN++ LN++ C TD + +S+ C +
Sbjct: 218 RWRLNVLRLNFRGCL-LRPKTFRSVS-HCRNLQELNVSDCPTFTDESMRHISEGCPGVLC 275
Query: 148 LDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALV--RGCGGLKALFLKGC 205
L+L++ T+ITN +++ L L+ L++++C + T G+Q L GC L L L GC
Sbjct: 276 LNLSN-TTITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGC 334
Query: 206 TQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAIL 265
TQ+ + +YI C ++ L + +TD + + C ++ SL +G +I+D
Sbjct: 335 TQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTF 394
Query: 266 NALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCP 325
AL + +LR + ++TD F + +N L + + +C ITDS+L LS
Sbjct: 395 RAL--SACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLS-PLK 451
Query: 326 RLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHL-KSCHSLERI 384
+L VL+L++C I D G++ +G A ++ + L NC ++DAS+ L + C +L +
Sbjct: 452 QLTVLNLANCVRIGDMGLKQFLDGP-ASMRIRELNLSNCVRLSDASVMKLSERCPNLNYL 510
Query: 385 ELYDCQQITRAGI 397
L +C+ +T GI
Sbjct: 511 SLRNCEHLTAQGI 523
Score = 99.4 bits (246), Expect = 6e-21
Identities = 81/299 (27%), Positives = 139/299 (46%), Gaps = 42/299 (14%)
Query: 85 ISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLS----- 139
I+ C G + L++ + DN ++ + C I L G +D T +LS
Sbjct: 345 IANSCTGIMH-LTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLR 403
Query: 140 ---------------KFCSK----LRHLDLASCTSITNMSLKALSEGCPL--LEQLNISW 178
KF K L H+ +A C IT+ SL++LS PL L LN++
Sbjct: 404 KIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLS---PLKQLTVLNLAN 460
Query: 179 CDQVTKDGIQALVRGCGGLKA--LFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITD 236
C ++ G++ + G ++ L L C +L D ++ + CP L L+L+ C +T
Sbjct: 461 CVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTA 520
Query: 237 EGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTT--- 293
+G+ I L S+ SG ++I++ LN L ++ +L+ L V+ C ++TD G
Sbjct: 521 QGIGYIVN-IFSLVSIDLSG-TDISNEGLNVLSRH-KKLKELSVSECYRITDDGIQITDS 577
Query: 294 ----LARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGN 348
L+ CH L +D+ CV +TD L L I C +L++L + +C I+ + + +
Sbjct: 578 AMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAAQRMSS 636
Score = 39.7 bits (91), Expect = 0.005
Identities = 24/79 (30%), Positives = 42/79 (53%), Gaps = 5/79 (6%)
Query: 323 HCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHL-KSCHSL 381
HC LQ L++S C TD+ +RH+ G + + L N IT+ ++ L + H+L
Sbjct: 243 HCRNLQELNVSDCPTFTDESMRHISEGCPG---VLCLNLSNTT-ITNRTMRLLPRHFHNL 298
Query: 382 ERIELYDCQQITRAGIKRL 400
+ + L C++ T G++ L
Sbjct: 299 QNLSLAYCRRFTDKGLQYL 317
>gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1
[Homo sapiens]
Length = 735
Score = 160 bits (406), Expect = 2e-39
Identities = 109/373 (29%), Positives = 196/373 (52%), Gaps = 10/373 (2%)
Query: 28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISK 87
LP+ +L+IF +L + + C QV+ AW ++ S W ID + I + + + +
Sbjct: 158 LPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQ 217
Query: 88 RCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRH 147
R + +L+ RGCL + R+ + +CRN++ LN++ C TD + +S+ C +
Sbjct: 218 RWRLNVLRLNFRGCL-LRPKTFRSVS-HCRNLQELNVSDCPTFTDESMRHISEGCPGVLC 275
Query: 148 LDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALV--RGCGGLKALFLKGC 205
L+L++ T+ITN +++ L L+ L++++C + T G+Q L GC L L L GC
Sbjct: 276 LNLSN-TTITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGC 334
Query: 206 TQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAIL 265
TQ+ + +YI C ++ L + +TD + + C ++ SL +G +I+D
Sbjct: 335 TQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTF 394
Query: 266 NALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCP 325
AL + +LR + ++TD F + +N L + + +C ITDS+L LS
Sbjct: 395 RAL--SACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLS-PLK 451
Query: 326 RLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHL-KSCHSLERI 384
+L VL+L++C I D G++ +G A ++ + L NC ++DAS+ L + C +L +
Sbjct: 452 QLTVLNLANCVRIGDMGLKQFLDGP-ASMRIRELNLSNCVRLSDASVMKLSERCPNLNYL 510
Query: 385 ELYDCQQITRAGI 397
L +C+ +T GI
Sbjct: 511 SLRNCEHLTAQGI 523
Score = 130 bits (327), Expect = 2e-30
Identities = 79/261 (30%), Positives = 136/261 (52%), Gaps = 12/261 (4%)
Query: 93 LRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCS-----KLRH 147
L + + C G+ D++LR+ + + + VLNL C + D L +F ++R
Sbjct: 428 LSHIYMADCKGITDSSLRSLSP-LKQLTVLNLANCVRIGDM---GLKQFLDGPASMRIRE 483
Query: 148 LDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQ 207
L+L++C +++ S+ LSE CP L L++ C+ +T GI +V L ++ L G T
Sbjct: 484 LNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVN-IFSLVSIDLSG-TD 541
Query: 208 LEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNA 267
+ +E L + H +L L++ C +ITD+G+ C+ L+ L S CS ++D I+ A
Sbjct: 542 ISNEGLNVLSRH-KKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKA 600
Query: 268 LGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRL 327
L C L L +A C ++TD L+ CH L +D+ CV +TD L L I C +L
Sbjct: 601 LAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQL 660
Query: 328 QVLSLSHCELITDDGIRHLGN 348
++L + +C I+ + + +
Sbjct: 661 RILKMQYCTNISKKAAQRMSS 681
Score = 118 bits (296), Expect = 9e-27
Identities = 88/287 (30%), Positives = 143/287 (49%), Gaps = 9/287 (3%)
Query: 93 LRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLAS 152
LRK+ G V D + + +N N+ + + C TD++ SLS +L L+LA+
Sbjct: 402 LRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPL-KQLTVLNLAN 460
Query: 153 CTSITNMSLKALSEG--CPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLED 210
C I +M LK +G + +LN+S C +++ + L C L L L+ C L
Sbjct: 461 CVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTA 520
Query: 211 EALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQ 270
+ + YI + LV+++L I++EGL + R KL+ L S C ITD + A +
Sbjct: 521 QGIGYI-VNIFSLVSIDLSGT-DISNEGLNVLSRH-KKLKELSVSECYRITDDGIQAFCK 577
Query: 271 NCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVL 330
+ L L+V+ CSQL+D+ LA C L + + C +ITDS + LS C L +L
Sbjct: 578 SSLILEHLDVSYCSQLSDMIIKALAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHIL 637
Query: 331 SLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKS 377
+S C L+TD + L G QL ++++ C I+ + + + S
Sbjct: 638 DISGCVLLTDQILEDLQIGC---KQLRILKMQYCTNISKKAAQRMSS 681
Score = 39.7 bits (91), Expect = 0.005
Identities = 24/79 (30%), Positives = 42/79 (53%), Gaps = 5/79 (6%)
Query: 323 HCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHL-KSCHSL 381
HC LQ L++S C TD+ +RH+ G + + L N IT+ ++ L + H+L
Sbjct: 243 HCRNLQELNVSDCPTFTDESMRHISEGCPG---VLCLNLSNTT-ITNRTMRLLPRHFHNL 298
Query: 382 ERIELYDCQQITRAGIKRL 400
+ + L C++ T G++ L
Sbjct: 299 QNLSLAYCRRFTDKGLQYL 317
Score = 30.0 bits (66), Expect = 4.3
Identities = 15/63 (23%), Positives = 28/63 (44%), Gaps = 1/63 (1%)
Query: 77 IEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCT 136
I +E +S +C +L L + GC+ + D L C+ + +L + CT +
Sbjct: 619 ITDSAMEMLSAKCH-YLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAAQ 677
Query: 137 SLS 139
+S
Sbjct: 678 RMS 680
>gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens]
Length = 418
Score = 148 bits (374), Expect = 8e-36
Identities = 123/388 (31%), Positives = 180/388 (46%), Gaps = 22/388 (5%)
Query: 31 ELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISKRCG 90
ELL IF +LDV R AQV AW A S W+ ++ R + ++ R
Sbjct: 11 ELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQARGI 70
Query: 91 GFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTD-ATCTSLSKFCSKLRHLD 149
++ LSLR +L Q NIE LNL+GC TD + + LR L+
Sbjct: 71 RRVQILSLR-------RSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLRALN 123
Query: 150 LASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLE 209
L+ C IT+ SL +++ LE L + C +T G+ + G LK+L L+ C L
Sbjct: 124 LSLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLS 183
Query: 210 DEALKYIGAH-------CPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITD 262
D + ++ C L L LQ C ++TD L I RG L+ L S C I+D
Sbjct: 184 DVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISD 243
Query: 263 AILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSI 322
A L L + LR L + C ++D G LA L +D+ C ++ D +L ++
Sbjct: 244 AGLLHLS-HMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYIAQ 302
Query: 323 HCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHL-KSCHSL 381
L+ LSL C I+DDGI + L + + C ITD LE + + L
Sbjct: 303 GLDGLKSLSLCSCH-ISDDGINRMVRQMHG---LRTLNIGQCVRITDKGLELIAEHLSQL 358
Query: 382 ERIELYDCQQITRAGIKRLRTHLPNIKV 409
I+LY C +IT+ G++R+ T LP +KV
Sbjct: 359 TGIDLYGCTRITKRGLERI-TQLPCLKV 385
>gi|24025682 F-box and leucine-rich repeat protein 16 [Homo sapiens]
Length = 479
Score = 123 bits (308), Expect = 4e-28
Identities = 109/395 (27%), Positives = 176/395 (44%), Gaps = 31/395 (7%)
Query: 30 KELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISKRC 89
+++L +F + C AQV +AW + W + + + + N+
Sbjct: 99 EKILNGLFWYFSACEKCVLAQVCKAWRRVLYQPKFWAGLTPV-----LHAKELYNVLP-- 151
Query: 90 GGFLRKLSLRG---------CL-GVGDNALRTFAQNC----RNIEVLNLNGCTKTTDATC 135
GG ++L+G CL GV D + F N + ++ ++L T TDA
Sbjct: 152 GGEKEFVNLQGFAARGFEGFCLVGVSDLDICEFIDNYALSKKGVKAMSLKRST-ITDAGL 210
Query: 136 TSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCG 195
+ + + L+L+ C T L S + L++S C V D I A+ +
Sbjct: 211 EVMLEQMQGVVRLELSGCNDFTEAGL--WSSLSARITSLSVSDCINVADDAIAAISQLLP 268
Query: 196 GLKALFLKGCTQLEDEALKYIGAHCPELV-TLNLQTCLQITDEGLITICRGCHKLQSLCA 254
L L L+ + D AL Y A TL L +C +IT+ G++ + L +L
Sbjct: 269 NLAELSLQ-AYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSLPNLTALSL 327
Query: 255 SGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITD 314
SGCS +TD + + +N +LR L+++ C ++TD+ +A + H LE++ L+ CV+ITD
Sbjct: 328 SGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVLDRCVRITD 387
Query: 315 STLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEH 374
+ L LS L+ L L C + D G++HL A L ++ CPL+T L
Sbjct: 388 TGLSYLST-MSSLRSLYLRWCCQVQDFGLKHL----LALGSLRLLSPAGCPLLTTTGLSG 442
Query: 375 LKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKV 409
L LE +EL +C T K HLP V
Sbjct: 443 LVQLQELEELELTNCPGATPELFKYFSQHLPRCLV 477
Score = 100 bits (250), Expect = 2e-21
Identities = 77/245 (31%), Positives = 116/245 (47%), Gaps = 17/245 (6%)
Query: 93 LRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRH----L 148
+ LS+ C+ V D+A+ +Q N+ L+L + T T+L+ F ++ H L
Sbjct: 244 ITSLSVSDCINVADDAIAAISQLLPNLAELSL----QAYHVTDTALAYFTARQGHSTHTL 299
Query: 149 DLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQL 208
L SC ITN + + P L L++S C +VT DG++ + L++L L C ++
Sbjct: 300 RLLSCWEITNHGVVNVVHSLPNLTALSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRI 359
Query: 209 EDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILN-- 266
D AL+Y+ L L L C++ITD GL + L+SL C + D L
Sbjct: 360 TDMALEYVACDLHRLEELVLDRCVRITDTGL-SYLSTMSSLRSLYLRWCCQVQDFGLKHL 418
Query: 267 -ALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCP 325
ALG LR+L A C LT G + L + ELE+++L C T S H P
Sbjct: 419 LALGS----LRLLSPAGCPLLTTTGLSGLVQ-LQELEELELTNCPGATPELFKYFSQHLP 473
Query: 326 RLQVL 330
R V+
Sbjct: 474 RCLVI 478
Score = 77.4 bits (189), Expect = 2e-14
Identities = 54/192 (28%), Positives = 96/192 (50%), Gaps = 3/192 (1%)
Query: 88 RCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRH 147
R G L L C + ++ + + N+ L+L+GC+K TD +++ KLR
Sbjct: 291 RQGHSTHTLRLLSCWEITNHGVVNVVHSLPNLTALSLSGCSKVTDDGVELVAENLRKLRS 350
Query: 148 LDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQ 207
LDL+ C IT+M+L+ ++ LE+L + C ++T G+ L L++L+L+ C Q
Sbjct: 351 LDLSWCPRITDMALEYVACDLHRLEELVLDRCVRITDTGLSYL-STMSSLRSLYLRWCCQ 409
Query: 208 LEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNA 267
++D LK++ A L L+ C +T GL + + +L+ L + C T +
Sbjct: 410 VQDFGLKHLLA-LGSLRLLSPAGCPLLTTTGLSGLVQ-LQELEELELTNCPGATPELFKY 467
Query: 268 LGQNCPRLRILE 279
Q+ PR ++E
Sbjct: 468 FSQHLPRCLVIE 479
>gi|16306588 F-box and leucine-rich repeat protein 4 [Homo sapiens]
Length = 621
Score = 112 bits (280), Expect = 7e-25
Identities = 101/394 (25%), Positives = 164/394 (41%), Gaps = 63/394 (15%)
Query: 27 KLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENIS 86
KLP EL+ I + L + LCR AQ + + D + ++L + ++
Sbjct: 282 KLPYELIQLILNHLTLPDLCRLAQTCKLLSQHCCDPLQYIHLNLQPYWAKLD-------- 333
Query: 87 KRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFC---- 142
D +L C ++ LNL+ + S+F
Sbjct: 334 -------------------DTSLEFLQSRCTLVQWLNLSWTGNRGFISVAGFSRFLKVCG 374
Query: 143 SKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFL 202
S+L L+L+ + L+ +SE CP L+ LN+S CD++ + + C LK L L
Sbjct: 375 SELVRLELSCSHFLNETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIAKLCS-LKRLVL 433
Query: 203 KGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITD 262
T++E AL I C EL L+L +C+ I D D
Sbjct: 434 YR-TKVEQTALLSILNFCSELQHLSLGSCVMIEDY------------------------D 468
Query: 263 AILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDST--LIQL 320
I + +G C +LR L++ RC +T+ G LA C LE++DL C + ST +L
Sbjct: 469 VIASMIGAKCKKLRTLDLWRCKNITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRL 528
Query: 321 SIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEH-LKSCH 379
+ P LQ L L+ + D I L AC +L+ +++ +++ ASL L+SC
Sbjct: 529 AHQLPNLQKLFLTANRSVCDTDIDEL---ACNCTRLQQLDILGTRMVSPASLRKLLESCK 585
Query: 380 SLERIELYDCQQITRAGIKRLRTHLPNIKVHAYF 413
L +++ C QI + L P + + F
Sbjct: 586 DLSLLDVSFCSQIDNRAVLELNASFPKVFIKKSF 619
>gi|164663798 antagonist of mitotic exit network 1 homolog [Homo
sapiens]
Length = 258
Score = 92.0 bits (227), Expect = 9e-19
Identities = 53/178 (29%), Positives = 92/178 (51%), Gaps = 9/178 (5%)
Query: 169 PLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGC----TQLEDEALKYIGAHCPELV 224
P ++ L++ CD D + C LK L L + E +K + + C L
Sbjct: 61 PEVQTLDLRSCD--ISDAALLHLSNCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSYLH 118
Query: 225 TLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCS 284
+L+ C +TDEG++ + C L+ + GC +ITD L+ALG+NCP L+ ++ + +
Sbjct: 119 EASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFS-AT 177
Query: 285 QLTDVGFTTLARN--CHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITD 340
Q++D G L +LE++ + CV +TD + + +CP++++L C LITD
Sbjct: 178 QVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGCPLITD 235
Score = 89.4 bits (220), Expect = 6e-18
Identities = 61/215 (28%), Positives = 105/215 (48%), Gaps = 28/215 (13%)
Query: 77 IEGRVVE-NISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATC 135
++G++ + NIS+ ++ L LR C + D AL + NCR ++ LNLN
Sbjct: 46 MQGQITDSNISEILHPEVQTLDLRSC-DISDAALLHLS-NCRKLKKLNLNA--------- 94
Query: 136 TSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCG 195
+ S+T+ +KA++ C L + ++ C +T +G+ AL C
Sbjct: 95 -------------SKGNRVSVTSEGIKAVASSCSYLHEASLKRCCNLTDEGVVALALNCQ 141
Query: 196 GLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRG--CHKLQSLC 253
LK + L GC + D +L +G +CP L ++ + Q++D G+I + G KL+ +
Sbjct: 142 LLKIIDLGGCLSITDVSLHALGKNCPFLQCVDF-SATQVSDSGVIALVSGPCAKKLEEIH 200
Query: 254 ASGCSNITDAILNALGQNCPRLRILEVARCSQLTD 288
C N+TD + A+ CP++RIL C +TD
Sbjct: 201 MGHCVNLTDGAVEAVLTYCPQIRILLFHGCPLITD 235
Score = 83.2 bits (204), Expect = 4e-16
Identities = 60/202 (29%), Positives = 100/202 (49%), Gaps = 14/202 (6%)
Query: 181 QVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTC----LQITD 236
Q+T I ++ ++ L L+ C + D AL ++ ++C +L LNL + +T
Sbjct: 49 QITDSNISEILHP--EVQTLDLRSC-DISDAALLHL-SNCRKLKKLNLNASKGNRVSVTS 104
Query: 237 EGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLAR 296
EG+ + C L C N+TD + AL NC L+I+++ C +TDV L +
Sbjct: 105 EGIKAVASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGK 164
Query: 297 NCHELEKMDLEECVQITDSTLIQL-SIHCPR-LQVLSLSHCELITDDGIRHLGNGACAHD 354
NC L+ +D Q++DS +I L S C + L+ + + HC +TD + +
Sbjct: 165 NCPFLQCVDFS-ATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYC---P 220
Query: 355 QLEVIELDNCPLITDASLEHLK 376
Q+ ++ CPLITD S E L+
Sbjct: 221 QIRILLFHGCPLITDHSREVLE 242
Score = 64.3 bits (155), Expect = 2e-10
Identities = 34/133 (25%), Positives = 70/133 (52%), Gaps = 4/133 (3%)
Query: 82 VENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKF 141
++ ++ C +L + SL+ C + D + A NC+ +++++L GC TD + +L K
Sbjct: 107 IKAVASSCS-YLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKN 165
Query: 142 CSKLRHLDLASCTSITNMSLKALSEG--CPLLEQLNISWCDQVTKDGIQALVRGCGGLKA 199
C L+ +D S T +++ + AL G LE++++ C +T ++A++ C ++
Sbjct: 166 CPFLQCVDF-SATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRI 224
Query: 200 LFLKGCTQLEDEA 212
L GC + D +
Sbjct: 225 LLFHGCPLITDHS 237
Score = 61.2 bits (147), Expect = 2e-09
Identities = 48/184 (26%), Positives = 88/184 (47%), Gaps = 15/184 (8%)
Query: 233 QITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCS----QLTD 288
QITD + I ++Q+L C +I+DA L L NC +L+ L + +T
Sbjct: 49 QITDSNISEILHP--EVQTLDLRSC-DISDAALLHLS-NCRKLKKLNLNASKGNRVSVTS 104
Query: 289 VGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGN 348
G +A +C L + L+ C +TD ++ L+++C L+++ L C ITD + LG
Sbjct: 105 EGIKAVASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGK 164
Query: 349 GACAHDQLEVIELDNCPLITDASLEHLKS---CHSLERIELYDCQQITRAGIKRLRTHLP 405
L+ ++ + ++D+ + L S LE I + C +T ++ + T+ P
Sbjct: 165 NC---PFLQCVDF-SATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCP 220
Query: 406 NIKV 409
I++
Sbjct: 221 QIRI 224
Score = 33.9 bits (76), Expect = 0.30
Identities = 21/101 (20%), Positives = 39/101 (38%), Gaps = 27/101 (26%)
Query: 93 LRKLSLRGCLGVGDNALRTFAQNC---------------------------RNIEVLNLN 125
L+ + L GCL + D +L +NC + +E +++
Sbjct: 143 LKIIDLGGCLSITDVSLHALGKNCPFLQCVDFSATQVSDSGVIALVSGPCAKKLEEIHMG 202
Query: 126 GCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSE 166
C TD ++ +C ++R L C IT+ S + L +
Sbjct: 203 HCVNLTDGAVEAVLTYCPQIRILLFHGCPLITDHSREVLEQ 243
>gi|254039600 F-box and leucine-rich repeat protein 17 [Homo
sapiens]
Length = 303
Score = 90.1 bits (222), Expect = 4e-18
Identities = 61/229 (26%), Positives = 111/229 (48%), Gaps = 5/229 (2%)
Query: 168 CPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLN 227
CP L + C Q++ I A+ C L+ + + +L DE LK +G+ C EL ++
Sbjct: 13 CPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIH 72
Query: 228 LQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLT 287
C +I+DEG+I I +GC KLQ + +TD + A ++CP L+ + CS +T
Sbjct: 73 FGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCS-VT 131
Query: 288 DVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLG 347
G L + L +DL ++ + T++++ C L L+L +I D + +
Sbjct: 132 SKGVIHLTK-LRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVI- 189
Query: 348 NGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAG 396
A L+ + L +C + A + + ++E +++ C++IT G
Sbjct: 190 --AKEGQNLKELYLVSCKITDYALIAIGRYSMTIETVDVGWCKEITDQG 236
Score = 86.3 bits (212), Expect = 5e-17
Identities = 61/290 (21%), Positives = 132/290 (45%), Gaps = 8/290 (2%)
Query: 104 VGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKA 163
+ DN + A C + C + +D + +++ C L+ + + + +T+ LK
Sbjct: 1 MSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQ 60
Query: 164 LSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPEL 223
L C L+ ++ C +++ +G+ + +GC L+ ++++ + D+++K HCPEL
Sbjct: 61 LGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPEL 120
Query: 224 VTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARC 283
+ C +T +G+I + + L SL + + + + + + C L L +
Sbjct: 121 QYVGFMGC-SVTSKGVIHLTK-LRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLN 178
Query: 284 SQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGI 343
+ D +A+ L+++ L C +ITD LI + + ++ + + C+ ITD G
Sbjct: 179 WIINDRCVEVIAKEGQNLKELYLVSC-KITDYALIAIGRYSMTIETVDVGWCKEITDQGA 237
Query: 344 RHLGNGACAHDQLEVIELDNCPLITDASLEHL--KSCHSLERIELYDCQQ 391
+ A + L + L C + + ++E L + H L DC++
Sbjct: 238 TLI---AQSSKSLRYLGLMRCDKVNEVTVEQLVQQYPHITFSTVLQDCKR 284
Score = 85.5 bits (210), Expect = 9e-17
Identities = 62/264 (23%), Positives = 114/264 (43%), Gaps = 26/264 (9%)
Query: 88 RCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRH 147
+C G LR + R C + D ++ A +C ++ +++ K TD L C +L+
Sbjct: 12 KCPGLLRYTAYR-CKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKD 70
Query: 148 LDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGC-- 205
+ C I++ + +++GC L+++ + VT ++A C L+ + GC
Sbjct: 71 IHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCSV 130
Query: 206 ----------------------TQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITIC 243
T+L++E + I C L +LNL I D + I
Sbjct: 131 TSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIA 190
Query: 244 RGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEK 303
+ L+ L C ITD L A+G+ + ++V C ++TD G T +A++ L
Sbjct: 191 KEGQNLKELYLVSC-KITDYALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRY 249
Query: 304 MDLEECVQITDSTLIQLSIHCPRL 327
+ L C ++ + T+ QL P +
Sbjct: 250 LGLMRCDKVNEVTVEQLVQQYPHI 273
Score = 62.0 bits (149), Expect = 1e-09
Identities = 34/124 (27%), Positives = 66/124 (53%), Gaps = 4/124 (3%)
Query: 286 LTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRH 345
++D G LA C L + C Q++D+++I ++ HCP LQ + + + + +TD+G++
Sbjct: 1 MSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQ 60
Query: 346 LGNGACAHDQLEVIELDNCPLITDASLEHL-KSCHSLERIELYDCQQITRAGIKRLRTHL 404
LG+ +L+ I C I+D + + K C L+RI + + + +T +K H
Sbjct: 61 LGSKC---RELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHC 117
Query: 405 PNIK 408
P ++
Sbjct: 118 PELQ 121
>gi|190194416 F-box and leucine-rich repeat protein 15 [Homo
sapiens]
Length = 300
Score = 89.0 bits (219), Expect = 8e-18
Identities = 65/240 (27%), Positives = 121/240 (50%), Gaps = 4/240 (1%)
Query: 32 LLLRIFSFLDVVTLCRCAQVSRAWNVLA-LDGSNWQRIDLFDFQRDIEGRVVENISKRCG 90
LL + + + + L R +VSRA+ L L + +R D I + + +
Sbjct: 28 LLPHVLNRVPLRQLLRLQRVSRAFRSLVQLHLAGLRRFDAAQVGPQIPRAALARLLRDAE 87
Query: 91 GFLRKLSLRGCLG-VGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLD 149
G L++L+L C + D L + + L GC + + +L++ C +L+ L
Sbjct: 88 G-LQELALAPCHEWLSDEDLVPVLARNPQLRSVALGGCGQLSRRALGALAEGCPRLQRLS 146
Query: 150 LASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCG-GLKALFLKGCTQL 208
LA C + ++L+ L++ CP LE+L+++ C Q+ + I L + G GL++L L +
Sbjct: 147 LAHCDWVDGLALRGLADRCPALEELDLTACRQLKDEAIVYLAQRRGAGLRSLSLAVNANV 206
Query: 209 EDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNAL 268
D A++ + +CPEL L+L CL++ +G+ T+ C L+SL C ++ ++ L+ L
Sbjct: 207 GDAAVQELARNCPELHHLDLTGCLRVGSDGVRTLAEYCPVLRSLRVRHCHHVAESSLSRL 266
Score = 86.3 bits (212), Expect = 5e-17
Identities = 55/190 (28%), Positives = 93/190 (48%), Gaps = 2/190 (1%)
Query: 133 ATCTSLSKFCSKLRHLDLASCTS-ITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALV 191
A L + L+ L LA C +++ L + P L + + C Q+++ + AL
Sbjct: 77 AALARLLRDAEGLQELALAPCHEWLSDEDLVPVLARNPQLRSVALGGCGQLSRRALGALA 136
Query: 192 RGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITIC-RGCHKLQ 250
GC L+ L L C ++ AL+ + CP L L+L C Q+ DE ++ + R L+
Sbjct: 137 EGCPRLQRLSLAHCDWVDGLALRGLADRCPALEELDLTACRQLKDEAIVYLAQRRGAGLR 196
Query: 251 SLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECV 310
SL + +N+ DA + L +NCP L L++ C ++ G TLA C L + + C
Sbjct: 197 SLSLAVNANVGDAAVQELARNCPELHHLDLTGCLRVGSDGVRTLAEYCPVLRSLRVRHCH 256
Query: 311 QITDSTLIQL 320
+ +S+L +L
Sbjct: 257 HVAESSLSRL 266
Score = 83.2 bits (204), Expect = 4e-16
Identities = 47/154 (30%), Positives = 78/154 (50%), Gaps = 1/154 (0%)
Query: 144 KLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLK 203
+LR + L C ++ +L AL+EGCP L++L+++ CD V ++ L C L+ L L
Sbjct: 115 QLRSVALGGCGQLSRRALGALAEGCPRLQRLSLAHCDWVDGLALRGLADRCPALEELDLT 174
Query: 204 GCTQLEDEALKYIG-AHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITD 262
C QL+DEA+ Y+ L +L+L + D + + R C +L L +GC +
Sbjct: 175 ACRQLKDEAIVYLAQRRGAGLRSLSLAVNANVGDAAVQELARNCPELHHLDLTGCLRVGS 234
Query: 263 AILNALGQNCPRLRILEVARCSQLTDVGFTTLAR 296
+ L + CP LR L V C + + + L +
Sbjct: 235 DGVRTLAEYCPVLRSLRVRHCHHVAESSLSRLRK 268
Score = 70.9 bits (172), Expect = 2e-12
Identities = 53/206 (25%), Positives = 93/206 (45%), Gaps = 6/206 (2%)
Query: 207 QLEDEALKYIGAHCPELVTLNLQTCLQ-ITDEGLITICRGCHKLQSLCASGCSNITDAIL 265
Q+ AL + L L L C + ++DE L+ + +L+S+ GC ++ L
Sbjct: 73 QIPRAALARLLRDAEGLQELALAPCHEWLSDEDLVPVLARNPQLRSVALGGCGQLSRRAL 132
Query: 266 NALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLS-IHC 324
AL + CPRL+ L +A C + + LA C LE++DL C Q+ D ++ L+
Sbjct: 133 GALAEGCPRLQRLSLAHCDWVDGLALRGLADRCPALEELDLTACRQLKDEAIVYLAQRRG 192
Query: 325 PRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHL-KSCHSLER 383
L+ LSL+ + D ++ L +L ++L C + + L + C L
Sbjct: 193 AGLRSLSLAVNANVGDAAVQELARNC---PELHHLDLTGCLRVGSDGVRTLAEYCPVLRS 249
Query: 384 IELYDCQQITRAGIKRLRTHLPNIKV 409
+ + C + + + RLR +I V
Sbjct: 250 LRVRHCHHVAESSLSRLRKRGVDIDV 275
Score = 35.8 bits (81), Expect = 0.078
Identities = 18/59 (30%), Positives = 31/59 (52%), Gaps = 1/59 (1%)
Query: 82 VENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSK 140
V+ +++ C L L L GCL VG + +RT A+ C + L + C +++ + L K
Sbjct: 211 VQELARNCPE-LHHLDLTGCLRVGSDGVRTLAEYCPVLRSLRVRHCHHVAESSLSRLRK 268
>gi|16306595 S-phase kinase-associated protein 2 isoform 1 [Homo
sapiens]
Length = 424
Score = 80.9 bits (198), Expect = 2e-15
Identities = 77/273 (28%), Positives = 127/273 (46%), Gaps = 25/273 (9%)
Query: 28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLF--DFQRDIEGRVVEN- 84
LP ELLL IFS L + L + + V + W LA D S WQ +DL + D+ GR++
Sbjct: 100 LPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQG 159
Query: 85 -ISKRCGGF--------------LRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTK 129
I+ RC ++ + L + + + L C ++ L+L G +
Sbjct: 160 VIAFRCPRSFMDQPLAEHFSPFRVQHMDLSNSV-IEVSTLHGILSQCSKLQNLSLEG-LR 217
Query: 130 TTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQ- 188
+D +L+K S L L+L+ C+ + +L+ L C L++LN+SWC T+ +Q
Sbjct: 218 LSDPIVNTLAK-NSNLVRLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQV 276
Query: 189 ALVRGCGGLKALFLKGCTQ-LEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCH 247
A+ + L L G + L+ L + CP LV L+L + + ++ + +
Sbjct: 277 AVAHVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQ-LN 335
Query: 248 KLQSLCASGCSNITDAILNALGQNCPRLRILEV 280
LQ L S C +I L LG+ P L+ L+V
Sbjct: 336 YLQHLSLSRCYDIIPETLLELGE-IPTLKTLQV 367
Score = 47.8 bits (112), Expect = 2e-05
Identities = 50/226 (22%), Positives = 103/226 (45%), Gaps = 16/226 (7%)
Query: 208 LEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNA 267
+E L I + C +L L+L+ L+++D + T+ + + L L SGCS ++ L
Sbjct: 193 IEVSTLHGILSQCSKLQNLSLEG-LRLSDPIVNTLAKNSN-LVRLNLSGCSGFSEFALQT 250
Query: 268 LGQNCPRLRILEVARCSQLTD----VGFTTLARNCHELEKMDLEECVQITD-STLIQLSI 322
L +C RL L ++ C T+ V ++ +L + +Q +D STL++
Sbjct: 251 LLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKSDLSTLVR--- 307
Query: 323 HCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLE 382
CP L L LS ++ +D + + L+ + L C I +L L +L+
Sbjct: 308 RCPNLVHLDLSDSVMLKNDCFQEF----FQLNYLQHLSLSRCYDIIPETLLELGEIPTLK 363
Query: 383 RIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSRQR 428
++++ + ++ L+ LP+++++ P++G + +
Sbjct: 364 TLQVFGI--VPDGTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQ 407
>gi|14249170 S-phase kinase-associated protein 2 isoform 2 [Homo
sapiens]
Length = 410
Score = 77.0 bits (188), Expect = 3e-14
Identities = 75/278 (26%), Positives = 126/278 (45%), Gaps = 24/278 (8%)
Query: 28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLF--DFQRDIEGRVVEN- 84
LP ELLL IFS L + L + + V + W LA D S WQ +DL + D+ GR++
Sbjct: 100 LPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQG 159
Query: 85 -ISKRCGGF--------------LRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTK 129
I+ RC ++ + L + + + L C ++ L+L G +
Sbjct: 160 VIAFRCPRSFMDQPLAEHFSPFRVQHMDLSNSV-IEVSTLHGILSQCSKLQNLSLEG-LR 217
Query: 130 TTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQ- 188
+D +L+K S L L+L+ C+ + +L+ L C L++LN+SWC T+ +Q
Sbjct: 218 LSDPIVNTLAK-NSNLVRLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQV 276
Query: 189 ALVRGCGGLKALFLKGCTQ-LEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCH 247
A+ + L L G + L+ L + CP LV L+L + + ++ + +
Sbjct: 277 AVAHVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQ-LN 335
Query: 248 KLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQ 285
LQ L S C +I L + + R+R+ C Q
Sbjct: 336 YLQHLSLSRCYDIIPETLLLVTRAGVRIRLDSDIGCPQ 373
Score = 40.4 bits (93), Expect = 0.003
Identities = 38/139 (27%), Positives = 67/139 (48%), Gaps = 10/139 (7%)
Query: 208 LEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNA 267
+E L I + C +L L+L+ L+++D + T+ + + L L SGCS ++ L
Sbjct: 193 IEVSTLHGILSQCSKLQNLSLEG-LRLSDPIVNTLAKNSN-LVRLNLSGCSGFSEFALQT 250
Query: 268 LGQNCPRLRILEVARCSQLTD----VGFTTLARNCHELEKMDLEECVQITD-STLIQLSI 322
L +C RL L ++ C T+ V ++ +L + +Q +D STL++
Sbjct: 251 LLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKSDLSTLVR--- 307
Query: 323 HCPRLQVLSLSHCELITDD 341
CP L L LS ++ +D
Sbjct: 308 RCPNLVHLDLSDSVMLKND 326
Score = 31.2 bits (69), Expect = 1.9
Identities = 25/87 (28%), Positives = 44/87 (50%), Gaps = 2/87 (2%)
Query: 258 SNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTL 317
S I + L+ + C +L+ L + +L+D TLA+N + L +++L C ++ L
Sbjct: 191 SVIEVSTLHGILSQCSKLQNLSLEGL-RLSDPIVNTLAKNSN-LVRLNLSGCSGFSEFAL 248
Query: 318 IQLSIHCPRLQVLSLSHCELITDDGIR 344
L C RL L+LS C T+ ++
Sbjct: 249 QTLLSSCSRLDELNLSWCFDFTEKHVQ 275
>gi|51873034 F-box and leucine-rich repeat protein 9 [Homo sapiens]
Length = 223
Score = 71.2 bits (173), Expect = 2e-12
Identities = 40/135 (29%), Positives = 72/135 (53%), Gaps = 1/135 (0%)
Query: 145 LRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKG 204
L+ LDL +C+ +T+ SL + + L QL++S ++T +G+ A+ RGC L+ L L
Sbjct: 77 LQELDLTACSKLTDASLAKVLQFLQL-RQLSLSLLPELTDNGLVAVARGCPSLEHLALSH 135
Query: 205 CTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAI 264
C++L D+ + P L LNL +C Q+ ++ L I + C +L+ L + C I A
Sbjct: 136 CSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATCPGINMAA 195
Query: 265 LNALGQNCPRLRILE 279
+ P++ ++
Sbjct: 196 VRRFQAQLPQVSCVQ 210
Score = 69.3 bits (168), Expect = 6e-12
Identities = 39/115 (33%), Positives = 63/115 (54%), Gaps = 1/115 (0%)
Query: 117 RNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNI 176
R ++ L+L C+K TDA+ + +F +LR L L+ +T+ L A++ GCP LE L +
Sbjct: 75 RALQELDLTACSKLTDASLAKVLQFL-QLRQLSLSLLPELTDNGLVAVARGCPSLEHLAL 133
Query: 177 SWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTC 231
S C +++ G L+ L L C+QL ++ L IG C +L L++ TC
Sbjct: 134 SHCSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATC 188
Score = 67.4 bits (163), Expect = 2e-11
Identities = 44/129 (34%), Positives = 69/129 (53%), Gaps = 4/129 (3%)
Query: 249 LQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEE 308
LQ L + CS +TDA L + Q +LR L ++ +LTD G +AR C LE + L
Sbjct: 77 LQELDLTACSKLTDASLAKVLQFL-QLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSH 135
Query: 309 CVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLIT 368
C +++D Q + PRLQ L+LS C + + + +G AC QL V+++ CP I
Sbjct: 136 CSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQ-ACR--QLRVLDVATCPGIN 192
Query: 369 DASLEHLKS 377
A++ ++
Sbjct: 193 MAAVRRFQA 201
Score = 66.6 bits (161), Expect = 4e-11
Identities = 49/185 (26%), Positives = 85/185 (45%), Gaps = 11/185 (5%)
Query: 143 SKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFL 202
S+L L LA C+S+ + P LE D + +L+ L+ L L
Sbjct: 33 SQLASLSLAHCSSLKSR---------PELEHQASGTKDACPEPQGPSLLT-LRALQELDL 82
Query: 203 KGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITD 262
C++L D +L + +L L+L ++TD GL+ + RGC L+ L S CS ++D
Sbjct: 83 TACSKLTDASLAKV-LQFLQLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSHCSRLSD 141
Query: 263 AILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSI 322
+ PRL+ L ++ CSQL + + + C +L +D+ C I + + +
Sbjct: 142 KGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATCPGINMAAVRRFQA 201
Query: 323 HCPRL 327
P++
Sbjct: 202 QLPQV 206
Score = 64.7 bits (156), Expect = 2e-10
Identities = 35/134 (26%), Positives = 73/134 (54%), Gaps = 5/134 (3%)
Query: 275 LRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSH 334
L+ L++ CS+LTD + + +L ++ L ++TD+ L+ ++ CP L+ L+LSH
Sbjct: 77 LQELDLTACSKLTDASLAKVLQFL-QLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSH 135
Query: 335 CELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHL-KSCHSLERIELYDCQQIT 393
C ++D G A + +L+ + L +C + + +L+ + ++C L +++ C I
Sbjct: 136 CSRLSDKG---WAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATCPGIN 192
Query: 394 RAGIKRLRTHLPNI 407
A ++R + LP +
Sbjct: 193 MAAVRRFQAQLPQV 206
Score = 62.4 bits (150), Expect = 8e-10
Identities = 46/154 (29%), Positives = 75/154 (48%), Gaps = 13/154 (8%)
Query: 202 LKGCTQLEDEALKYIGAHCPE-----------LVTLNLQTCLQITDEGLITICRGCHKLQ 250
LK +LE +A A CPE L L+L C ++TD L + + +L+
Sbjct: 46 LKSRPELEHQASGTKDA-CPEPQGPSLLTLRALQELDLTACSKLTDASLAKVLQFL-QLR 103
Query: 251 SLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECV 310
L S +TD L A+ + CP L L ++ CS+L+D G+ A + L+ ++L C
Sbjct: 104 QLSLSLLPELTDNGLVAVARGCPSLEHLALSHCSRLSDKGWAQAASSWPRLQHLNLSSCS 163
Query: 311 QITDSTLIQLSIHCPRLQVLSLSHCELITDDGIR 344
Q+ + TL + C +L+VL ++ C I +R
Sbjct: 164 QLIEQTLDAIGQACRQLRVLDVATCPGINMAAVR 197
Score = 54.3 bits (129), Expect = 2e-07
Identities = 32/131 (24%), Positives = 65/131 (49%), Gaps = 1/131 (0%)
Query: 93 LRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLAS 152
L++L L C + D +L Q + + L+L+ + TD ++++ C L HL L+
Sbjct: 77 LQELDLTACSKLTDASLAKVLQFLQ-LRQLSLSLLPELTDNGLVAVARGCPSLEHLALSH 135
Query: 153 CTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEA 212
C+ +++ + P L+ LN+S C Q+ + + A+ + C L+ L + C + A
Sbjct: 136 CSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATCPGINMAA 195
Query: 213 LKYIGAHCPEL 223
++ A P++
Sbjct: 196 VRRFQAQLPQV 206
Score = 30.8 bits (68), Expect = 2.5
Identities = 24/108 (22%), Positives = 48/108 (44%), Gaps = 29/108 (26%)
Query: 301 LEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIE 360
L+++DL C ++TD++L ++ + +L+ LSLS +TD+G+ + G
Sbjct: 77 LQELDLTACSKLTDASLAKV-LQFLQLRQLSLSLLPELTDNGLVAVARG----------- 124
Query: 361 LDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIK 408
C SLE + L C +++ G + + P ++
Sbjct: 125 -----------------CPSLEHLALSHCSRLSDKGWAQAASSWPRLQ 155
Score = 30.0 bits (66), Expect = 4.3
Identities = 25/96 (26%), Positives = 44/96 (45%), Gaps = 13/96 (13%)
Query: 326 RLQVLSLSHCE-LITDDGIRHLGNG---ACAHDQ---------LEVIELDNCPLITDASL 372
+L LSL+HC L + + H +G AC Q L+ ++L C +TDASL
Sbjct: 34 QLASLSLAHCSSLKSRPELEHQASGTKDACPEPQGPSLLTLRALQELDLTACSKLTDASL 93
Query: 373 EHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIK 408
+ L ++ L ++T G+ + P+++
Sbjct: 94 AKVLQFLQLRQLSLSLLPELTDNGLVAVARGCPSLE 129
>gi|16306591 F-box and leucine-rich repeat protein 9 [Homo sapiens]
Length = 223
Score = 71.2 bits (173), Expect = 2e-12
Identities = 40/135 (29%), Positives = 72/135 (53%), Gaps = 1/135 (0%)
Query: 145 LRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKG 204
L+ LDL +C+ +T+ SL + + L QL++S ++T +G+ A+ RGC L+ L L
Sbjct: 77 LQELDLTACSKLTDASLAKVLQFLQL-RQLSLSLLPELTDNGLVAVARGCPSLEHLALSH 135
Query: 205 CTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAI 264
C++L D+ + P L LNL +C Q+ ++ L I + C +L+ L + C I A
Sbjct: 136 CSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATCPGINMAA 195
Query: 265 LNALGQNCPRLRILE 279
+ P++ ++
Sbjct: 196 VRRFQAQLPQVSCVQ 210
Score = 69.3 bits (168), Expect = 6e-12
Identities = 39/115 (33%), Positives = 63/115 (54%), Gaps = 1/115 (0%)
Query: 117 RNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNI 176
R ++ L+L C+K TDA+ + +F +LR L L+ +T+ L A++ GCP LE L +
Sbjct: 75 RALQELDLTACSKLTDASLAKVLQFL-QLRQLSLSLLPELTDNGLVAVARGCPSLEHLAL 133
Query: 177 SWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTC 231
S C +++ G L+ L L C+QL ++ L IG C +L L++ TC
Sbjct: 134 SHCSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATC 188
Score = 67.4 bits (163), Expect = 2e-11
Identities = 44/129 (34%), Positives = 69/129 (53%), Gaps = 4/129 (3%)
Query: 249 LQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEE 308
LQ L + CS +TDA L + Q +LR L ++ +LTD G +AR C LE + L
Sbjct: 77 LQELDLTACSKLTDASLAKVLQFL-QLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSH 135
Query: 309 CVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLIT 368
C +++D Q + PRLQ L+LS C + + + +G AC QL V+++ CP I
Sbjct: 136 CSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQ-ACR--QLRVLDVATCPGIN 192
Query: 369 DASLEHLKS 377
A++ ++
Sbjct: 193 MAAVRRFQA 201
Score = 66.6 bits (161), Expect = 4e-11
Identities = 49/185 (26%), Positives = 85/185 (45%), Gaps = 11/185 (5%)
Query: 143 SKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFL 202
S+L L LA C+S+ + P LE D + +L+ L+ L L
Sbjct: 33 SQLASLSLAHCSSLKSR---------PELEHQASGTKDACPEPQGPSLLT-LRALQELDL 82
Query: 203 KGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITD 262
C++L D +L + +L L+L ++TD GL+ + RGC L+ L S CS ++D
Sbjct: 83 TACSKLTDASLAKV-LQFLQLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSHCSRLSD 141
Query: 263 AILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSI 322
+ PRL+ L ++ CSQL + + + C +L +D+ C I + + +
Sbjct: 142 KGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATCPGINMAAVRRFQA 201
Query: 323 HCPRL 327
P++
Sbjct: 202 QLPQV 206
Score = 64.7 bits (156), Expect = 2e-10
Identities = 35/134 (26%), Positives = 73/134 (54%), Gaps = 5/134 (3%)
Query: 275 LRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSH 334
L+ L++ CS+LTD + + +L ++ L ++TD+ L+ ++ CP L+ L+LSH
Sbjct: 77 LQELDLTACSKLTDASLAKVLQFL-QLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSH 135
Query: 335 CELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHL-KSCHSLERIELYDCQQIT 393
C ++D G A + +L+ + L +C + + +L+ + ++C L +++ C I
Sbjct: 136 CSRLSDKG---WAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATCPGIN 192
Query: 394 RAGIKRLRTHLPNI 407
A ++R + LP +
Sbjct: 193 MAAVRRFQAQLPQV 206
Score = 62.4 bits (150), Expect = 8e-10
Identities = 46/154 (29%), Positives = 75/154 (48%), Gaps = 13/154 (8%)
Query: 202 LKGCTQLEDEALKYIGAHCPE-----------LVTLNLQTCLQITDEGLITICRGCHKLQ 250
LK +LE +A A CPE L L+L C ++TD L + + +L+
Sbjct: 46 LKSRPELEHQASGTKDA-CPEPQGPSLLTLRALQELDLTACSKLTDASLAKVLQFL-QLR 103
Query: 251 SLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECV 310
L S +TD L A+ + CP L L ++ CS+L+D G+ A + L+ ++L C
Sbjct: 104 QLSLSLLPELTDNGLVAVARGCPSLEHLALSHCSRLSDKGWAQAASSWPRLQHLNLSSCS 163
Query: 311 QITDSTLIQLSIHCPRLQVLSLSHCELITDDGIR 344
Q+ + TL + C +L+VL ++ C I +R
Sbjct: 164 QLIEQTLDAIGQACRQLRVLDVATCPGINMAAVR 197
Score = 54.3 bits (129), Expect = 2e-07
Identities = 32/131 (24%), Positives = 65/131 (49%), Gaps = 1/131 (0%)
Query: 93 LRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLAS 152
L++L L C + D +L Q + + L+L+ + TD ++++ C L HL L+
Sbjct: 77 LQELDLTACSKLTDASLAKVLQFLQ-LRQLSLSLLPELTDNGLVAVARGCPSLEHLALSH 135
Query: 153 CTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEA 212
C+ +++ + P L+ LN+S C Q+ + + A+ + C L+ L + C + A
Sbjct: 136 CSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATCPGINMAA 195
Query: 213 LKYIGAHCPEL 223
++ A P++
Sbjct: 196 VRRFQAQLPQV 206
Score = 30.8 bits (68), Expect = 2.5
Identities = 24/108 (22%), Positives = 48/108 (44%), Gaps = 29/108 (26%)
Query: 301 LEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIE 360
L+++DL C ++TD++L ++ + +L+ LSLS +TD+G+ + G
Sbjct: 77 LQELDLTACSKLTDASLAKV-LQFLQLRQLSLSLLPELTDNGLVAVARG----------- 124
Query: 361 LDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIK 408
C SLE + L C +++ G + + P ++
Sbjct: 125 -----------------CPSLEHLALSHCSRLSDKGWAQAASSWPRLQ 155
Score = 30.0 bits (66), Expect = 4.3
Identities = 25/96 (26%), Positives = 44/96 (45%), Gaps = 13/96 (13%)
Query: 326 RLQVLSLSHCE-LITDDGIRHLGNG---ACAHDQ---------LEVIELDNCPLITDASL 372
+L LSL+HC L + + H +G AC Q L+ ++L C +TDASL
Sbjct: 34 QLASLSLAHCSSLKSRPELEHQASGTKDACPEPQGPSLLTLRALQELDLTACSKLTDASL 93
Query: 373 EHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIK 408
+ L ++ L ++T G+ + P+++
Sbjct: 94 AKVLQFLQLRQLSLSLLPELTDNGLVAVARGCPSLE 129
>gi|157168349 F-box and leucine-rich repeat protein 19 [Homo
sapiens]
Length = 694
Score = 68.9 bits (167), Expect = 8e-12
Identities = 76/273 (27%), Positives = 115/273 (42%), Gaps = 27/273 (9%)
Query: 28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISK 87
LP+ LR+F L LC C +V R W+ D W R+DL ++ + ++ + +
Sbjct: 424 LPRAAWLRVFQHLGPRELCICMRVCRTWSRWCYDKRLWPRMDL-SRRKSLTPPMLSGVVR 482
Query: 88 RCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRH 147
R R L L GV L + ++ L L+GC+ + + S LR
Sbjct: 483 RQP---RALDL-SWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAP--LPALRL 536
Query: 148 LDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRG-CGGLKALFLKGCT 206
LDL + + L+ L P TK G Q RG G+ L L G
Sbjct: 537 LDLRWIEDVKDSQLRELLLPPP------------DTKPG-QTESRGRLQGVAELRLAG-L 582
Query: 207 QLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQS----LCASGCSNITD 262
+L D +L+ + H P+L L+L C + D + + L+ L +GC +TD
Sbjct: 583 ELTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTD 642
Query: 263 AILNALGQNCPRLRILEVARCSQLTDVGFTTLA 295
L L + CPRLR L++ C QL+ LA
Sbjct: 643 HCL-PLFRRCPRLRRLDLRSCRQLSPEACARLA 674
Score = 53.5 bits (127), Expect = 4e-07
Identities = 49/183 (26%), Positives = 85/183 (46%), Gaps = 20/183 (10%)
Query: 234 ITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQN-CPRLRILEV-----ARCSQLT 287
++ + L+ + LQ L SGCS ++ ++ALG P LR+L++ + SQL
Sbjct: 495 VSKKQLMWLLNRLQGLQELVLSGCSWLS---VSALGSAPLPALRLLDLRWIEDVKDSQLR 551
Query: 288 DV---------GFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELI 338
++ G T + ++ L +++TD++L L H P+L L LSHC +
Sbjct: 552 ELLLPPPDTKPGQTESRGRLQGVAELRLAG-LELTDASLRLLLRHAPQLSALDLSHCAHV 610
Query: 339 TDDGIRHL-GNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGI 397
D + L + + L + L C +TD L + C L R++L C+Q++
Sbjct: 611 GDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLRSCRQLSPEAC 670
Query: 398 KRL 400
RL
Sbjct: 671 ARL 673
Score = 42.0 bits (97), Expect = 0.001
Identities = 34/103 (33%), Positives = 49/103 (47%), Gaps = 12/103 (11%)
Query: 131 TDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGC-PLLE---QLNISWCDQVTKDG 186
TDA+ L + +L LDL+ C + + S+ L+ PL E LN++ C ++T D
Sbjct: 585 TDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLT-DH 643
Query: 187 IQALVRGCGGLKALFLKGCTQLEDEALKYIGA-------HCPE 222
L R C L+ L L+ C QL EA + A CPE
Sbjct: 644 CLPLFRRCPRLRRLDLRSCRQLSPEACARLAAAGPPGPFRCPE 686
Score = 37.7 bits (86), Expect = 0.021
Identities = 26/81 (32%), Positives = 36/81 (44%), Gaps = 5/81 (6%)
Query: 93 LRKLSLRGCLGVGDNALRTFAQNCRNIEV----LNLNGCTKTTDATCTSLSKFCSKLRHL 148
L L L C VGD ++ + LNL GC + TD C L + C +LR L
Sbjct: 599 LSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDH-CLPLFRRCPRLRRL 657
Query: 149 DLASCTSITNMSLKALSEGCP 169
DL SC ++ + L+ P
Sbjct: 658 DLRSCRQLSPEACARLAAAGP 678
>gi|54112382 F-box and leucine-rich repeat protein 10 isoform a [Homo
sapiens]
Length = 1336
Score = 67.8 bits (164), Expect = 2e-11
Identities = 54/169 (31%), Positives = 74/169 (43%), Gaps = 24/169 (14%)
Query: 249 LQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLA------------- 295
L+ L SGCS I A+ +CP LR L+V L D L
Sbjct: 1151 LRDLVLSGCSWI--AVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDN 1208
Query: 296 ----RNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHL-GNGA 350
RN EL L+ ITD++L + H P L L LS+C +TD I L G
Sbjct: 1209 RSKLRNIVELRLAGLD----ITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGT 1264
Query: 351 CAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKR 399
D L I L +C +TD L K C ++ I+L C+Q+T+ G ++
Sbjct: 1265 TTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQ 1313
Score = 65.9 bits (159), Expect = 7e-11
Identities = 68/249 (27%), Positives = 106/249 (42%), Gaps = 45/249 (18%)
Query: 30 KELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVE------ 83
+E+ + +FS+L LC C +V R WN D W RIDL + + I ++
Sbjct: 1067 REVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDL-NHCKSITPLMLSGIIRRQ 1125
Query: 84 ---------NISKRCGGF-------LRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGC 127
NISK+ + LR L L GC + +AL + +C + L++
Sbjct: 1126 PVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSAL--CSSSCPLLRTLDVQWV 1183
Query: 128 TKTTDATCTSL-----------SKFCSKLRH---LDLASCTSITNMSLKALSEGCPLLEQ 173
DA L SKLR+ L LA IT+ SL+ + PLL +
Sbjct: 1184 EGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAG-LDITDASLRLIIRHMPLLSK 1242
Query: 174 LNISWCDQVTKDGIQAL----VRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQ 229
L++S+C+ VT I L L + L C ++ D+ L + C + ++L+
Sbjct: 1243 LHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFF-KRCGNICHIDLR 1301
Query: 230 TCLQITDEG 238
C Q+T EG
Sbjct: 1302 YCKQVTKEG 1310
Score = 54.7 bits (130), Expect = 2e-07
Identities = 61/250 (24%), Positives = 98/250 (39%), Gaps = 70/250 (28%)
Query: 135 CTSLSKFCSKLR---HLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALV 191
C + +++C R +DL C SIT + L + P+ L++SW + ++K + L+
Sbjct: 1089 CRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPV--SLDLSWTN-ISKKQLSWLI 1145
Query: 192 RGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTC-------------------- 231
GL+ L L GC+ + AL + CP L TL++Q
Sbjct: 1146 NRLPGLRDLVLSGCSWIAVSAL--CSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRP 1203
Query: 232 -------------------LQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNC 272
L ITD L I R L L S C+++TD +N
Sbjct: 1204 GQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINL----- 1258
Query: 273 PRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSL 332
LT VG TT L +++L +C ++TD L C + + L
Sbjct: 1259 -------------LTAVGTTTR----DSLTEINLSDCNKVTDQCL-SFFKRCGNICHIDL 1300
Query: 333 SHCELITDDG 342
+C+ +T +G
Sbjct: 1301 RYCKQVTKEG 1310
Score = 40.4 bits (93), Expect = 0.003
Identities = 41/168 (24%), Positives = 79/168 (47%), Gaps = 10/168 (5%)
Query: 30 KELLLRIFSFLDVVTLCRCA-QVSRAWNVLALDG-SNWQRIDLFDFQRDIEGRVVENISK 87
++L+L S++ V LC + + R +V ++G + Q DL D ++N SK
Sbjct: 1152 RDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSK 1211
Query: 88 RCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLR- 146
+ +L L G L + D +LR ++ + L+L+ C TD + L+ + R
Sbjct: 1212 LRN--IVELRLAG-LDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRD 1268
Query: 147 ---HLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALV 191
++L+ C +T+ L C + +++ +C QVTK+G + +
Sbjct: 1269 SLTEINLSDCNKVTDQCLSFFKR-CGNICHIDLRYCKQVTKEGCEQFI 1315
>gi|54112380 F-box and leucine-rich repeat protein 10 isoform b [Homo
sapiens]
Length = 1265
Score = 67.8 bits (164), Expect = 2e-11
Identities = 54/169 (31%), Positives = 74/169 (43%), Gaps = 24/169 (14%)
Query: 249 LQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLA------------- 295
L+ L SGCS I A+ +CP LR L+V L D L
Sbjct: 1082 LRDLVLSGCSWI--AVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDN 1139
Query: 296 ----RNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHL-GNGA 350
RN EL L+ ITD++L + H P L L LS+C +TD I L G
Sbjct: 1140 RSKLRNIVELRLAGLD----ITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGT 1195
Query: 351 CAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKR 399
D L I L +C +TD L K C ++ I+L C+Q+T+ G ++
Sbjct: 1196 TTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQ 1244
Score = 65.9 bits (159), Expect = 7e-11
Identities = 68/249 (27%), Positives = 106/249 (42%), Gaps = 45/249 (18%)
Query: 30 KELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVE------ 83
+E+ + +FS+L LC C +V R WN D W RIDL + + I ++
Sbjct: 998 REVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDL-NHCKSITPLMLSGIIRRQ 1056
Query: 84 ---------NISKRCGGF-------LRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGC 127
NISK+ + LR L L GC + +AL + +C + L++
Sbjct: 1057 PVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSAL--CSSSCPLLRTLDVQWV 1114
Query: 128 TKTTDATCTSL-----------SKFCSKLRH---LDLASCTSITNMSLKALSEGCPLLEQ 173
DA L SKLR+ L LA IT+ SL+ + PLL +
Sbjct: 1115 EGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAG-LDITDASLRLIIRHMPLLSK 1173
Query: 174 LNISWCDQVTKDGIQAL----VRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQ 229
L++S+C+ VT I L L + L C ++ D+ L + C + ++L+
Sbjct: 1174 LHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFF-KRCGNICHIDLR 1232
Query: 230 TCLQITDEG 238
C Q+T EG
Sbjct: 1233 YCKQVTKEG 1241
Score = 54.7 bits (130), Expect = 2e-07
Identities = 61/250 (24%), Positives = 98/250 (39%), Gaps = 70/250 (28%)
Query: 135 CTSLSKFCSKLR---HLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALV 191
C + +++C R +DL C SIT + L + P+ L++SW + ++K + L+
Sbjct: 1020 CRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPV--SLDLSWTN-ISKKQLSWLI 1076
Query: 192 RGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTC-------------------- 231
GL+ L L GC+ + AL + CP L TL++Q
Sbjct: 1077 NRLPGLRDLVLSGCSWIAVSAL--CSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRP 1134
Query: 232 -------------------LQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNC 272
L ITD L I R L L S C+++TD +N
Sbjct: 1135 GQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINL----- 1189
Query: 273 PRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSL 332
LT VG TT L +++L +C ++TD L C + + L
Sbjct: 1190 -------------LTAVGTTTR----DSLTEINLSDCNKVTDQCL-SFFKRCGNICHIDL 1231
Query: 333 SHCELITDDG 342
+C+ +T +G
Sbjct: 1232 RYCKQVTKEG 1241
Score = 40.4 bits (93), Expect = 0.003
Identities = 41/168 (24%), Positives = 79/168 (47%), Gaps = 10/168 (5%)
Query: 30 KELLLRIFSFLDVVTLCRCA-QVSRAWNVLALDG-SNWQRIDLFDFQRDIEGRVVENISK 87
++L+L S++ V LC + + R +V ++G + Q DL D ++N SK
Sbjct: 1083 RDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSK 1142
Query: 88 RCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLR- 146
+ +L L G L + D +LR ++ + L+L+ C TD + L+ + R
Sbjct: 1143 LRN--IVELRLAG-LDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRD 1199
Query: 147 ---HLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALV 191
++L+ C +T+ L C + +++ +C QVTK+G + +
Sbjct: 1200 SLTEINLSDCNKVTDQCLSFFKR-CGNICHIDLRYCKQVTKEGCEQFI 1246
>gi|16306576 F-box and leucine-rich repeat protein 6 isoform 1 [Homo
sapiens]
Length = 539
Score = 65.1 bits (157), Expect = 1e-10
Identities = 99/432 (22%), Positives = 163/432 (37%), Gaps = 43/432 (9%)
Query: 27 KLPKELLLRIFSFLDVVT-----LCRCAQVSRAWNVLALDGSNWQRIDLFD--FQRDIEG 79
++P E+L++IF L L R A+V R W A + W + L R +G
Sbjct: 114 RIPLEILVQIFGLLVAADGPMPFLGRAARVCRRWQEAASQPALWHTVTLSSPLVGRPAKG 173
Query: 80 RV---------VENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKT 130
V +E + L++L+L L+ + C + L L+GC
Sbjct: 174 GVKAEKKLLASLEWLMPNRFSQLQRLTLIHWKSQVHPVLKLVGECCPRLTFLKLSGCHGV 233
Query: 131 TDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQAL 190
T L+K C +L LDL + + L E + +L +++ Q T L
Sbjct: 234 TADALVMLAKACCQLHSLDLQHSMVESTAVVSFLEEAGSRMRKLWLTYSSQTTAILGALL 293
Query: 191 VRGCGGLKALFLKG-------CTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITIC 243
C L+ L + QL EAL+ CP+L L L + + +
Sbjct: 294 GSCCPQLQVLEVSTGINRNSIPLQLPVEALQ---KGCPQLQVLRLLNLMWLPKPPGRGVA 350
Query: 244 --RGCHKLQSLC--ASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCH 299
G L+ LC +S C+ +++ +L L P LR+L++ C+++T G L C
Sbjct: 351 PGPGFPSLEELCLASSTCNFVSNEVLGRLLHGSPNLRLLDLRGCARITPAGLQDLP--CR 408
Query: 300 ELEKMDL------EECVQITDSTLIQLSIHCPRLQVLSLSHCELITDD----GIRHLGNG 349
ELE++ L + + + C L+ L LS D L
Sbjct: 409 ELEQLHLGLYGTSDRLTLAKEGSPFLTQKWCHTLRELDLSGQGFSEKDLEQALAAFLSTP 468
Query: 350 ACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKV 409
+H L + L + + SC L + L C+ + R G+KR L ++
Sbjct: 469 GGSHPALCSLNLRGTRVTPSTVSSVISSCPGLLYLNLESCRCLPR-GLKRAYRGLEEVQW 527
Query: 410 HAYFAPVTPPPS 421
+P PS
Sbjct: 528 CLEQLLTSPSPS 539
>gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens]
Length = 1162
Score = 63.9 bits (154), Expect = 3e-10
Identities = 70/264 (26%), Positives = 110/264 (41%), Gaps = 50/264 (18%)
Query: 135 CTSLSKFCSKLR---HLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALV 191
C + K+C R +DL+ C +I +L + + P+ L++SW + ++K + LV
Sbjct: 917 CKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPV--SLDLSWTN-ISKKQLTWLV 973
Query: 192 RGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQS 251
GLK L L GC+ AL + CP L TL+L+
Sbjct: 974 NRLPGLKDLLLAGCSWSAVSALST--SSCPLLRTLDLRW--------------------- 1010
Query: 252 LCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQ 311
A+G P++R L + + L RN + L+
Sbjct: 1011 ---------------AVGIKDPQIRDLLTPPADKPGQDNRSKL-RNMTDFRLAGLD---- 1050
Query: 312 ITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHL-GNGACAHDQLEVIELDNCPLITDA 370
ITD+TL + H P L L LSHC +TD L G+ L + + C +TD
Sbjct: 1051 ITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQ 1110
Query: 371 SLEHLKSCHSLERIELYDCQQITR 394
+L +L+ ++ I+L C+QITR
Sbjct: 1111 TLIYLRRIANVTLIDLRGCKQITR 1134
Score = 53.1 bits (126), Expect = 5e-07
Identities = 68/298 (22%), Positives = 121/298 (40%), Gaps = 37/298 (12%)
Query: 28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISK 87
+ +E+ + +F +L LC C +V + W D W +IDL + I + + I K
Sbjct: 893 MQREVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDL-SRCKAIVPQALSGIIK 951
Query: 88 RCGGFLRKLSL-RGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLR 146
R + +SL + L ++ L L GC+ + + ++ S C LR
Sbjct: 952 R-----QPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSS--CPLLR 1004
Query: 147 HLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCT 206
LDL I + P + L D+ +D ++ +R + L
Sbjct: 1005 TLDLRWAVGIKD----------PQIRDLLTPPADKPGQDN-RSKLRNMTDFRLAGL---- 1049
Query: 207 QLEDEALKYIGAHCPELVTLNLQTCLQITDE--GLITICRGC--HKLQSLCASGCSNITD 262
+ D L+ I H P L L+L C +TD+ L+T + L L +GC+ +TD
Sbjct: 1050 DITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTD 1109
Query: 263 AILNALGQNCPRLRILEVARCSQLTDVGFTTLARNC-HELEKMDLEECVQITDSTLIQ 319
L L + + ++++ C Q+T + C H + + + ++D LIQ
Sbjct: 1110 QTLIYL-RRIANVTLIDLRGCKQIT-------RKACEHFISDLSINSLYCLSDEKLIQ 1159
>gi|8923179 F-box and leucine-rich repeat protein 12 [Homo sapiens]
Length = 326
Score = 62.0 bits (149), Expect = 1e-09
Identities = 76/294 (25%), Positives = 122/294 (41%), Gaps = 50/294 (17%)
Query: 27 KLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENIS 86
+LP +LL IFS+L V R ++V W L D W+ +DL + + +V+ ++
Sbjct: 6 ELPDSVLLEIFSYLPVRDRIRISRVCHRWKRLVDDRWLWRHVDLTLY--TMRPKVMWHLL 63
Query: 87 KR-CGGFLRKLSLRGCLGVGDNA-------LRTFAQNCRNIEVLNLNGCTKTTDATCTSL 138
+R L L + G L G A LR Q C N++ L C D + +
Sbjct: 64 RRYMASRLHSLRMGGYLFSGSQAPQLSPALLRALGQKCPNLKRL----CLHVADLSMVPI 119
Query: 139 SKFCSKLRHLDLASC-TSITNMSLKALSEGCPLLE------------------------- 172
+ S LR L+L SC S+ + + PLLE
Sbjct: 120 TSLPSTLRTLELHSCEISMAWLHKQQDPTVLPLLECIVLDRVPAFRDEHLQGLTRFRALR 179
Query: 173 QLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCL 232
L + +VT+ G+ A ++ L+ L + GCT D L I H ++ + L T
Sbjct: 180 SLVLGGTYRVTETGLDAGLQELSYLQRLEVLGCTLSADSTLLAISRHLRDVRKIRL-TVR 238
Query: 233 QITDEGLITICRGCHKLQSLCASG------CSNITDAILNALGQNCPRLRILEV 280
++ GL + G L+SLC G + T+ + + L P+LR+LE+
Sbjct: 239 GLSAPGL-AVLEGMPALESLCLQGPLVTPEMPSPTEILSSCL--TMPKLRVLEL 289
>gi|61742136 F-box and leucine-rich repeat protein 6 isoform 2 [Homo
sapiens]
Length = 533
Score = 60.1 bits (144), Expect = 4e-09
Identities = 98/429 (22%), Positives = 159/429 (37%), Gaps = 43/429 (10%)
Query: 27 KLPKELLLRIFSFLDVVT-----LCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRV 81
++P E+L++IF L L R A+V R W A + W + L + GR
Sbjct: 114 RIPLEILVQIFGLLVAADGPMPFLGRAARVCRRWQEAASQPALWHTVTL---SSPLVGRP 170
Query: 82 VENISKRCGGFLRKL--------SLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDA 133
+ K L L S L + + + C + L L+GC T
Sbjct: 171 AKGGVKAEKKLLASLEWLMPNRFSQLQRLTLIHWKSQLVGECCPRLTFLKLSGCHGVTAD 230
Query: 134 TCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRG 193
L+K C +L LDL + + L E + +L +++ Q T L
Sbjct: 231 ALVMLAKACCQLHSLDLQHSMVESTAVVSFLEEAGSRMRKLWLTYSSQTTAILGALLGSC 290
Query: 194 CGGLKALFLKG-------CTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITIC--R 244
C L+ L + QL EAL+ CP+L L L + + +
Sbjct: 291 CPQLQVLEVSTGINRNSIPLQLPVEALQ---KGCPQLQVLRLLNLMWLPKPPGRGVAPGP 347
Query: 245 GCHKLQSLC--ASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELE 302
G L+ LC +S C+ +++ +L L P LR+L++ C+++T G L C ELE
Sbjct: 348 GFPSLEELCLASSTCNFVSNEVLGRLLHGSPNLRLLDLRGCARITPAGLQDLP--CRELE 405
Query: 303 KMDL------EECVQITDSTLIQLSIHCPRLQVLSLSHCELITDD----GIRHLGNGACA 352
++ L + + + C L+ L LS D L +
Sbjct: 406 QLHLGLYGTSDRLTLAKEGSPFLTQKWCHTLRELDLSGQGFSEKDLEQALAAFLSTPGGS 465
Query: 353 HDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAY 412
H L + L + + SC L + L C+ + R G+KR L ++
Sbjct: 466 HPALCSLNLRGTRVTPSTVSSVISSCPGLLYLNLESCRCLPR-GLKRAYRGLEEVQWCLE 524
Query: 413 FAPVTPPPS 421
+P PS
Sbjct: 525 QLLTSPSPS 533
>gi|16306574 F-box and leucine-rich repeat protein 5 isoform 2 [Homo
sapiens]
Length = 565
Score = 57.0 bits (136), Expect = 3e-08
Identities = 53/205 (25%), Positives = 80/205 (39%), Gaps = 62/205 (30%)
Query: 28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGS--------NWQRIDLF-------- 71
LP E++L IFS+L+ LCRC+QVS W+ L GS +W R D +
Sbjct: 82 LPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHWARGDWYSGPATELD 141
Query: 72 ---------------------DFQRDIEGR----------------------VVENISKR 88
D DI+ ++ N+
Sbjct: 142 TEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVLPY 201
Query: 89 CGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKF--CSKLR 146
G ++ L L V +R + C N+E L+L T +D+ S S C LR
Sbjct: 202 VGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQ-TDISDSAFDSWSWLGCCQSLR 260
Query: 147 HLDLASCTSITNMSLKALSEGCPLL 171
HLDL+ C IT+++L+ +S +L
Sbjct: 261 HLDLSGCEKITDVALEKISRALGIL 285
Score = 41.2 bits (95), Expect = 0.002
Identities = 24/66 (36%), Positives = 33/66 (50%), Gaps = 2/66 (3%)
Query: 145 LRHLDLASCTSITNMSLKALS--EGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFL 202
L L L+ C IT+ L+ L+ G P LE LN+S C +T G+Q LV C L +
Sbjct: 474 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 533
Query: 203 KGCTQL 208
C +
Sbjct: 534 YYCDNI 539
Score = 39.7 bits (91), Expect = 0.005
Identities = 30/82 (36%), Positives = 37/82 (45%), Gaps = 3/82 (3%)
Query: 223 LVTLNLQTCLQITDEGL--ITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEV 280
L+ L+L C QITD GL +T+ G L+ L SGC IT A L L CP L
Sbjct: 474 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 533
Query: 281 ARCSQLTDVGFTTLARNCHELE 302
C + T A C L+
Sbjct: 534 YYCDNINGPHADT-ASGCQNLQ 554
Score = 38.5 bits (88), Expect = 0.012
Identities = 24/63 (38%), Positives = 28/63 (44%), Gaps = 2/63 (3%)
Query: 200 LFLKGCTQLEDEALKYI--GAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGC 257
L L GC Q+ D L+ + G P L LNL CL IT GL + C L C
Sbjct: 477 LSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYC 536
Query: 258 SNI 260
NI
Sbjct: 537 DNI 539
Score = 37.4 bits (85), Expect = 0.027
Identities = 42/140 (30%), Positives = 57/140 (40%), Gaps = 11/140 (7%)
Query: 127 CTKTTDATCTSL---SKFCSKLRHLDLASCTSITNM-SLKALSEGCPLLEQLNISWCDQV 182
CT T T +SL S C K L + S K+ E +L L++S C Q+
Sbjct: 426 CTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQI 485
Query: 183 TKDGIQALVRGCG--GLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLI 240
T G++ L G G L+ L L GC + L+ + + CP L C I
Sbjct: 486 TDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNINGPHAD 545
Query: 241 TICRGCHKLQ----SLCASG 256
T GC LQ + C SG
Sbjct: 546 T-ASGCQNLQCGFRACCRSG 564
Score = 37.4 bits (85), Expect = 0.027
Identities = 29/67 (43%), Positives = 32/67 (47%), Gaps = 2/67 (2%)
Query: 327 LQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKS-CHSLERIE 385
L LSLS C ITD G+R L G LE + L C IT A L+ L S C SL
Sbjct: 474 LLFLSLSGCYQITDHGLRVLTLGG-GLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEY 532
Query: 386 LYDCQQI 392
Y C I
Sbjct: 533 FYYCDNI 539
Score = 36.2 bits (82), Expect = 0.060
Identities = 29/92 (31%), Positives = 36/92 (39%), Gaps = 3/92 (3%)
Query: 83 ENISKRCGGFLRKLSLRGCLGVGDNALR--TFAQNCRNIEVLNLNGCTKTTDATCTSLSK 140
E + G L LSL GC + D+ LR T +E LNL+GC T A L
Sbjct: 464 EKSDQETGRVLLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVS 523
Query: 141 FCSKLRHLDLASCTSITNMSLKALSEGCPLLE 172
C L C +I S GC L+
Sbjct: 524 ACPSLNDEYFYYCDNINGPHADTAS-GCQNLQ 554
Score = 32.7 bits (73), Expect = 0.66
Identities = 22/66 (33%), Positives = 31/66 (46%), Gaps = 2/66 (3%)
Query: 275 LRILEVARCSQLTDVGFT--TLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSL 332
L L ++ C Q+TD G TL LE ++L C+ IT + L L CP L
Sbjct: 474 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 533
Query: 333 SHCELI 338
+C+ I
Sbjct: 534 YYCDNI 539
Score = 29.3 bits (64), Expect = 7.3
Identities = 18/75 (24%), Positives = 40/75 (53%), Gaps = 3/75 (4%)
Query: 249 LQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLA--RNCHELEKMDL 306
+++L + S ++ ++ + + CP L L++ + + ++D F + + C L +DL
Sbjct: 206 VKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQ-TDISDSAFDSWSWLGCCQSLRHLDL 264
Query: 307 EECVQITDSTLIQLS 321
C +ITD L ++S
Sbjct: 265 SGCEKITDVALEKIS 279
>gi|16306572 F-box and leucine-rich repeat protein 5 isoform 1 [Homo
sapiens]
Length = 691
Score = 57.0 bits (136), Expect = 3e-08
Identities = 53/205 (25%), Positives = 80/205 (39%), Gaps = 62/205 (30%)
Query: 28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGS--------NWQRIDLF-------- 71
LP E++L IFS+L+ LCRC+QVS W+ L GS +W R D +
Sbjct: 208 LPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHWARGDWYSGPATELD 267
Query: 72 ---------------------DFQRDIEGR----------------------VVENISKR 88
D DI+ ++ N+
Sbjct: 268 TEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVLPY 327
Query: 89 CGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKF--CSKLR 146
G ++ L L V +R + C N+E L+L T +D+ S S C LR
Sbjct: 328 VGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQ-TDISDSAFDSWSWLGCCQSLR 386
Query: 147 HLDLASCTSITNMSLKALSEGCPLL 171
HLDL+ C IT+++L+ +S +L
Sbjct: 387 HLDLSGCEKITDVALEKISRALGIL 411
Score = 41.2 bits (95), Expect = 0.002
Identities = 24/66 (36%), Positives = 33/66 (50%), Gaps = 2/66 (3%)
Query: 145 LRHLDLASCTSITNMSLKALS--EGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFL 202
L L L+ C IT+ L+ L+ G P LE LN+S C +T G+Q LV C L +
Sbjct: 600 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 659
Query: 203 KGCTQL 208
C +
Sbjct: 660 YYCDNI 665
Score = 39.7 bits (91), Expect = 0.005
Identities = 30/82 (36%), Positives = 37/82 (45%), Gaps = 3/82 (3%)
Query: 223 LVTLNLQTCLQITDEGL--ITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEV 280
L+ L+L C QITD GL +T+ G L+ L SGC IT A L L CP L
Sbjct: 600 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 659
Query: 281 ARCSQLTDVGFTTLARNCHELE 302
C + T A C L+
Sbjct: 660 YYCDNINGPHADT-ASGCQNLQ 680
Score = 38.5 bits (88), Expect = 0.012
Identities = 24/63 (38%), Positives = 28/63 (44%), Gaps = 2/63 (3%)
Query: 200 LFLKGCTQLEDEALKYI--GAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGC 257
L L GC Q+ D L+ + G P L LNL CL IT GL + C L C
Sbjct: 603 LSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYC 662
Query: 258 SNI 260
NI
Sbjct: 663 DNI 665
Score = 37.4 bits (85), Expect = 0.027
Identities = 42/140 (30%), Positives = 57/140 (40%), Gaps = 11/140 (7%)
Query: 127 CTKTTDATCTSL---SKFCSKLRHLDLASCTSITNM-SLKALSEGCPLLEQLNISWCDQV 182
CT T T +SL S C K L + S K+ E +L L++S C Q+
Sbjct: 552 CTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQI 611
Query: 183 TKDGIQALVRGCG--GLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLI 240
T G++ L G G L+ L L GC + L+ + + CP L C I
Sbjct: 612 TDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNINGPHAD 671
Query: 241 TICRGCHKLQ----SLCASG 256
T GC LQ + C SG
Sbjct: 672 T-ASGCQNLQCGFRACCRSG 690
Score = 37.4 bits (85), Expect = 0.027
Identities = 29/67 (43%), Positives = 32/67 (47%), Gaps = 2/67 (2%)
Query: 327 LQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKS-CHSLERIE 385
L LSLS C ITD G+R L G LE + L C IT A L+ L S C SL
Sbjct: 600 LLFLSLSGCYQITDHGLRVLTLGG-GLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEY 658
Query: 386 LYDCQQI 392
Y C I
Sbjct: 659 FYYCDNI 665
Score = 36.2 bits (82), Expect = 0.060
Identities = 29/92 (31%), Positives = 36/92 (39%), Gaps = 3/92 (3%)
Query: 83 ENISKRCGGFLRKLSLRGCLGVGDNALR--TFAQNCRNIEVLNLNGCTKTTDATCTSLSK 140
E + G L LSL GC + D+ LR T +E LNL+GC T A L
Sbjct: 590 EKSDQETGRVLLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVS 649
Query: 141 FCSKLRHLDLASCTSITNMSLKALSEGCPLLE 172
C L C +I S GC L+
Sbjct: 650 ACPSLNDEYFYYCDNINGPHADTAS-GCQNLQ 680
Score = 32.7 bits (73), Expect = 0.66
Identities = 22/66 (33%), Positives = 31/66 (46%), Gaps = 2/66 (3%)
Query: 275 LRILEVARCSQLTDVGFT--TLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSL 332
L L ++ C Q+TD G TL LE ++L C+ IT + L L CP L
Sbjct: 600 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 659
Query: 333 SHCELI 338
+C+ I
Sbjct: 660 YYCDNI 665
Score = 29.3 bits (64), Expect = 7.3
Identities = 18/75 (24%), Positives = 40/75 (53%), Gaps = 3/75 (4%)
Query: 249 LQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLA--RNCHELEKMDL 306
+++L + S ++ ++ + + CP L L++ + + ++D F + + C L +DL
Sbjct: 332 VKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQ-TDISDSAFDSWSWLGCCQSLRHLDL 390
Query: 307 EECVQITDSTLIQLS 321
C +ITD L ++S
Sbjct: 391 SGCEKITDVALEKIS 405
>gi|122937219 F-box protein 41 [Homo sapiens]
Length = 936
Score = 50.8 bits (120), Expect = 2e-06
Identities = 70/291 (24%), Positives = 114/291 (39%), Gaps = 30/291 (10%)
Query: 17 SNSDEAVINKKLP-KELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRI------- 68
S S+E + + L + L IF++LD TL A+V R W +A + W R+
Sbjct: 601 SRSNEVISPEILKMRAALFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRVLLENARV 660
Query: 69 ------DLFDFQRDIEGRVVENISKRCGGFLRK-----LSLRGCLGVGDNALRTFAQNCR 117
L + ++N+ R G S RGCL G +L A
Sbjct: 661 CSKFLAMLAQWCTQAHSLTLQNLKPRQRGKKESKEEYARSTRGCLEAGLESLLKAAGG-- 718
Query: 118 NIEVLNLNGCTK-TTDATCTSLSKFCSKLRHLDLASCTS-ITNMSLKALSEGCPLLEQLN 175
N+ +L ++ C TD + S +C L+ + S T + + + AL GC + L
Sbjct: 719 NLLILRISHCPNILTDRSLWLASCYCRALQAVTYRSATDPVGHEVIWALGAGCREIVSLQ 778
Query: 176 IS---WCDQVTKDG---IQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQ 229
++ C Q T+ +Q + R L+AL + G + L + +C L L L
Sbjct: 779 VAPLHPCQQPTRFSNRCLQMIGRCWPHLRALGVGG-AGCGVQGLASLARNCMRLQVLELD 837
Query: 230 TCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEV 280
+IT E +CR K + + +T L C L+ + V
Sbjct: 838 HVSEITQEVAAEVCREGLKGLEMLVLTATPVTPKALLHFNSICRNLKSIVV 888
>gi|30795121 F-box and WD repeat domain containing 8 isoform 2
[Homo sapiens]
Length = 532
Score = 45.4 bits (106), Expect = 1e-04
Identities = 22/50 (44%), Positives = 30/50 (60%)
Query: 19 SDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRI 68
+D + +LP EL + IF +LD L RCAQVS+ W V+A D W R+
Sbjct: 44 NDVPFFDIQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRL 93
>gi|30795123 F-box and WD repeat domain containing 8 isoform 1 [Homo
sapiens]
Length = 598
Score = 45.4 bits (106), Expect = 1e-04
Identities = 22/50 (44%), Positives = 30/50 (60%)
Query: 19 SDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRI 68
+D + +LP EL + IF +LD L RCAQVS+ W V+A D W R+
Sbjct: 110 NDVPFFDIQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRL 159
>gi|30089926 F-box only protein 11 isoform 1 [Homo sapiens]
Length = 843
Score = 42.0 bits (97), Expect = 0.001
Identities = 22/57 (38%), Positives = 37/57 (64%), Gaps = 2/57 (3%)
Query: 21 EAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRI--DLFDFQR 75
E + +KLP E++L+IFS+L LCR A V + ++ LA D W+R+ ++F++ R
Sbjct: 68 EQYLQEKLPDEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILWKRLYMEVFEYTR 124
>gi|30089924 F-box only protein 11 isoform 2 [Homo sapiens]
Length = 686
Score = 42.0 bits (97), Expect = 0.001
Identities = 22/57 (38%), Positives = 37/57 (64%), Gaps = 2/57 (3%)
Query: 21 EAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRI--DLFDFQR 75
E + +KLP E++L+IFS+L LCR A V + ++ LA D W+R+ ++F++ R
Sbjct: 68 EQYLQEKLPDEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILWKRLYMEVFEYTR 124
>gi|30089922 F-box only protein 11 isoform 3 [Homo sapiens]
Length = 585
Score = 42.0 bits (97), Expect = 0.001
Identities = 22/57 (38%), Positives = 37/57 (64%), Gaps = 2/57 (3%)
Query: 21 EAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRI--DLFDFQR 75
E + +KLP E++L+IFS+L LCR A V + ++ LA D W+R+ ++F++ R
Sbjct: 68 EQYLQEKLPDEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILWKRLYMEVFEYTR 124
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.138 0.432
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,194,443
Number of Sequences: 37866
Number of extensions: 684277
Number of successful extensions: 2769
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 48
Number of HSP's successfully gapped in prelim test: 37
Number of HSP's that attempted gapping in prelim test: 2155
Number of HSP's gapped (non-prelim): 229
length of query: 436
length of database: 18,247,518
effective HSP length: 105
effective length of query: 331
effective length of database: 14,271,588
effective search space: 4723895628
effective search space used: 4723895628
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.