Guide to the Human Genome
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Search of human proteins with 27502415

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27502415 CD46 antigen, complement regulatory protein isoform
9 precursor [Homo sapiens]
         (363 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27502415 CD46 antigen, complement regulatory protein isoform ...   775   0.0  
gi|27502407 CD46 antigen, complement regulatory protein isoform ...   765   0.0  
gi|27502413 CD46 antigen, complement regulatory protein isoform ...   764   0.0  
gi|27502402 CD46 antigen, complement regulatory protein isoform ...   755   0.0  
gi|27502409 CD46 antigen, complement regulatory protein isoform ...   749   0.0  
gi|27502417 CD46 antigen, complement regulatory protein isoform ...   743   0.0  
gi|27502419 CD46 antigen, complement regulatory protein isoform ...   739   0.0  
gi|24432108 CD46 antigen, complement regulatory protein isoform ...   733   0.0  
gi|27502425 CD46 antigen, complement regulatory protein isoform ...   733   0.0  
gi|27502423 CD46 antigen, complement regulatory protein isoform ...   723   0.0  
gi|27502411 CD46 antigen, complement regulatory protein isoform ...   717   0.0  
gi|27502427 CD46 antigen, complement regulatory protein isoform ...   707   0.0  
gi|27502421 CD46 antigen, complement regulatory protein isoform ...   689   0.0  
gi|27502405 CD46 antigen, complement regulatory protein isoform ...   674   0.0  
gi|148922949 complement component (3b/4b) receptor 1-like [Homo ...   191   1e-48
gi|4502503 complement component 4 binding protein, alpha chain p...   174   1e-43
gi|86793109 complement receptor 1 isoform S precursor [Homo sapi...   154   9e-38
gi|86793036 complement receptor 1 isoform F precursor [Homo sapi...   154   9e-38
gi|42544177 complement component (3d/Epstein Barr virus) recepto...   138   9e-33
gi|54792123 complement component (3d/Epstein Barr virus) recepto...   137   1e-32
gi|148886654 polydom [Homo sapiens]                                   122   5e-28
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap...   110   3e-24
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa...   110   3e-24
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap...   110   3e-24
gi|153266841 apolipoprotein H precursor [Homo sapiens]                108   6e-24
gi|168693643 decay accelerating factor for complement isoform 2 ...   107   2e-23
gi|10835143 decay accelerating factor for complement isoform 1 p...   107   2e-23
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]          104   1e-22
gi|62739188 complement factor H isoform b precursor [Homo sapiens]    101   1e-21
gi|62739186 complement factor H isoform a precursor [Homo sapiens]    101   1e-21

>gi|27502415 CD46 antigen, complement regulatory protein isoform 9
           precursor [Homo sapiens]
          Length = 363

 Score =  775 bits (2000), Expect = 0.0
 Identities = 363/363 (100%), Positives = 363/363 (100%)

Query: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
           MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60

Query: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
           DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120

Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
           YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180

Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
           FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240

Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSAS 300
           GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSAS
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSAS 300

Query: 301 GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKF 360
           GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKF
Sbjct: 301 GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKF 360

Query: 361 TSL 363
           TSL
Sbjct: 361 TSL 363


>gi|27502407 CD46 antigen, complement regulatory protein isoform 3
           precursor [Homo sapiens]
          Length = 377

 Score =  765 bits (1975), Expect = 0.0
 Identities = 363/377 (96%), Positives = 363/377 (96%), Gaps = 14/377 (3%)

Query: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
           MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60

Query: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
           DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120

Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
           YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180

Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
           FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240

Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSAS 300
           GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSAS
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSAS 300

Query: 301 --------------GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKK 346
                         GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKK
Sbjct: 301 GPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKK 360

Query: 347 GTYLTDETHREVKFTSL 363
           GTYLTDETHREVKFTSL
Sbjct: 361 GTYLTDETHREVKFTSL 377


>gi|27502413 CD46 antigen, complement regulatory protein isoform 7
           precursor [Homo sapiens]
          Length = 378

 Score =  764 bits (1974), Expect = 0.0
 Identities = 363/378 (96%), Positives = 363/378 (96%), Gaps = 15/378 (3%)

Query: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
           MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60

Query: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
           DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120

Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
           YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180

Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
           FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240

Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK--------------- 285
           GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK               
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS 300

Query: 286 VSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK 345
           VSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK
Sbjct: 301 VSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK 360

Query: 346 KGTYLTDETHREVKFTSL 363
           KGTYLTDETHREVKFTSL
Sbjct: 361 KGTYLTDETHREVKFTSL 378


>gi|27502402 CD46 antigen, complement regulatory protein isoform 1
           precursor [Homo sapiens]
          Length = 392

 Score =  755 bits (1949), Expect = 0.0
 Identities = 363/392 (92%), Positives = 363/392 (92%), Gaps = 29/392 (7%)

Query: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
           MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60

Query: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
           DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120

Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
           YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180

Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
           FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240

Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK--------------- 285
           GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK               
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS 300

Query: 286 VSTSSTTKSPASSAS--------------GYPKPEEGILDSLDVWVIAVIVIAIVVGVAV 331
           VSTSSTTKSPASSAS              GYPKPEEGILDSLDVWVIAVIVIAIVVGVAV
Sbjct: 301 VSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIVVGVAV 360

Query: 332 ICVVPYRYLQRRKKKGTYLTDETHREVKFTSL 363
           ICVVPYRYLQRRKKKGTYLTDETHREVKFTSL
Sbjct: 361 ICVVPYRYLQRRKKKGTYLTDETHREVKFTSL 392


>gi|27502409 CD46 antigen, complement regulatory protein isoform 5
           precursor [Homo sapiens]
          Length = 362

 Score =  749 bits (1934), Expect = 0.0
 Identities = 352/363 (96%), Positives = 353/363 (97%), Gaps = 1/363 (0%)

Query: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
           MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60

Query: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
           DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120

Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
           YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180

Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
           FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240

Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSAS 300
           GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK     T K P S+  
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK-GPRPTYKPPVSNYP 299

Query: 301 GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKF 360
           GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKF
Sbjct: 300 GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKF 359

Query: 361 TSL 363
           TSL
Sbjct: 360 TSL 362


>gi|27502417 CD46 antigen, complement regulatory protein isoform 10
           precursor [Homo sapiens]
          Length = 370

 Score =  743 bits (1917), Expect = 0.0
 Identities = 347/347 (100%), Positives = 347/347 (100%)

Query: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
           MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60

Query: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
           DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120

Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
           YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180

Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
           FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240

Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSAS 300
           GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSAS
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSAS 300

Query: 301 GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKG 347
           GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKG
Sbjct: 301 GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKG 347


>gi|27502419 CD46 antigen, complement regulatory protein isoform 11
           precursor [Homo sapiens]
          Length = 348

 Score =  739 bits (1907), Expect = 0.0
 Identities = 348/363 (95%), Positives = 348/363 (95%), Gaps = 15/363 (4%)

Query: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
           MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60

Query: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
           DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120

Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
           YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180

Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
           FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240

Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSAS 300
           GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK               
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK--------------- 285

Query: 301 GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKF 360
           GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKF
Sbjct: 286 GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKF 345

Query: 361 TSL 363
           TSL
Sbjct: 346 TSL 348


>gi|24432108 CD46 antigen, complement regulatory protein isoform 4
           precursor [Homo sapiens]
          Length = 384

 Score =  733 bits (1892), Expect = 0.0
 Identities = 347/361 (96%), Positives = 347/361 (96%), Gaps = 14/361 (3%)

Query: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
           MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60

Query: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
           DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120

Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
           YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180

Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
           FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240

Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSAS 300
           GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSAS
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSAS 300

Query: 301 --------------GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKK 346
                         GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKK
Sbjct: 301 GPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKK 360

Query: 347 G 347
           G
Sbjct: 361 G 361


>gi|27502425 CD46 antigen, complement regulatory protein isoform 8
           precursor [Homo sapiens]
          Length = 385

 Score =  733 bits (1891), Expect = 0.0
 Identities = 347/362 (95%), Positives = 347/362 (95%), Gaps = 15/362 (4%)

Query: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
           MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60

Query: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
           DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120

Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
           YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180

Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
           FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240

Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK--------------- 285
           GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK               
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS 300

Query: 286 VSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK 345
           VSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK
Sbjct: 301 VSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK 360

Query: 346 KG 347
           KG
Sbjct: 361 KG 362


>gi|27502423 CD46 antigen, complement regulatory protein isoform 2
           precursor [Homo sapiens]
          Length = 399

 Score =  723 bits (1866), Expect = 0.0
 Identities = 347/376 (92%), Positives = 347/376 (92%), Gaps = 29/376 (7%)

Query: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
           MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60

Query: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
           DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120

Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
           YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180

Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
           FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240

Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK--------------- 285
           GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK               
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS 300

Query: 286 VSTSSTTKSPASSAS--------------GYPKPEEGILDSLDVWVIAVIVIAIVVGVAV 331
           VSTSSTTKSPASSAS              GYPKPEEGILDSLDVWVIAVIVIAIVVGVAV
Sbjct: 301 VSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIVVGVAV 360

Query: 332 ICVVPYRYLQRRKKKG 347
           ICVVPYRYLQRRKKKG
Sbjct: 361 ICVVPYRYLQRRKKKG 376


>gi|27502411 CD46 antigen, complement regulatory protein isoform 6
           precursor [Homo sapiens]
          Length = 369

 Score =  717 bits (1851), Expect = 0.0
 Identities = 336/347 (96%), Positives = 337/347 (97%), Gaps = 1/347 (0%)

Query: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
           MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60

Query: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
           DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120

Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
           YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180

Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
           FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240

Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSAS 300
           GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK     T K P S+  
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK-GPRPTYKPPVSNYP 299

Query: 301 GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKG 347
           GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKG
Sbjct: 300 GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKG 346


>gi|27502427 CD46 antigen, complement regulatory protein isoform 12
           precursor [Homo sapiens]
          Length = 355

 Score =  707 bits (1824), Expect = 0.0
 Identities = 332/347 (95%), Positives = 332/347 (95%), Gaps = 15/347 (4%)

Query: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
           MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60

Query: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
           DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120

Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
           YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180

Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
           FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240

Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSAS 300
           GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK               
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK--------------- 285

Query: 301 GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKG 347
           GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKG
Sbjct: 286 GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKG 332


>gi|27502421 CD46 antigen, complement regulatory protein isoform 13
           precursor [Homo sapiens]
          Length = 373

 Score =  689 bits (1779), Expect = 0.0
 Identities = 325/339 (95%), Positives = 325/339 (95%), Gaps = 14/339 (4%)

Query: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
           MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60

Query: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
           DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120

Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
           YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180

Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
           FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240

Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSAS 300
           GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSAS
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSAS 300

Query: 301 --------------GYPKPEEGILDSLDVWVIAVIVIAI 325
                         GYPKPEEGILDSLDVWVIAVIVIAI
Sbjct: 301 GPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAI 339


>gi|27502405 CD46 antigen, complement regulatory protein isoform 14
           precursor [Homo sapiens]
          Length = 349

 Score =  674 bits (1738), Expect = 0.0
 Identities = 314/325 (96%), Positives = 315/325 (96%), Gaps = 1/325 (0%)

Query: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
           MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60

Query: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
           DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61  DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120

Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
           YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180

Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
           FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240

Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSAS 300
           GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK     T K P S+  
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK-GPRPTYKPPVSNYP 299

Query: 301 GYPKPEEGILDSLDVWVIAVIVIAI 325
           GYPKPEEGILDSLDVWVIAVIVIAI
Sbjct: 300 GYPKPEEGILDSLDVWVIAVIVIAI 324


>gi|148922949 complement component (3b/4b) receptor 1-like [Homo
           sapiens]
          Length = 569

 Score =  191 bits (484), Expect = 1e-48
 Identities = 111/293 (37%), Positives = 148/293 (50%), Gaps = 12/293 (4%)

Query: 1   MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPY-YEIGER 59
           M PP R E PFPS RFPGLLLAA+VLLL SFSD C  P              + + IG  
Sbjct: 1   MAPPVRLERPFPSRRFPGLLLAALVLLLSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTY 60

Query: 60  VDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEF 119
           ++Y+C+ GY   P      IC +N  W    D  C R++C    DP+NG A       +F
Sbjct: 61  LNYECRPGYSGRP---FSIICLKNSVWTSAKDK-CKRKSCRNPPDPVNGMAHVIKDI-QF 115

Query: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVE 179
             Q+ + C +GY LIG     C + G+  IW  K P+C++++C  PP I NG  T    E
Sbjct: 116 RSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISRE 175

Query: 180 VFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVV 233
            F Y   VTY C+  + G   F L+GE +IYC        +WS  AP+C +  KC  P V
Sbjct: 176 YFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNV 235

Query: 234 ENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286
           ENG  +S     F     V F C  GF + G   + C + + W+P +P C +V
Sbjct: 236 ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRV 288



 Score =  105 bits (262), Expect = 6e-23
 Identities = 61/176 (34%), Positives = 91/176 (51%), Gaps = 6/176 (3%)

Query: 55  EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114
           ++G +VD+ C +G+      A++ +     +    S   C R++C     P+NG  V   
Sbjct: 369 QLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGM-VHVI 427

Query: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHT 174
                G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG+HT
Sbjct: 428 TDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHT 487

Query: 175 FSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD----NSVWSRAAPECKV 225
            + +    Y   V+Y+CDP P     F+LIGESTI        N VWS  AP C++
Sbjct: 488 GTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCEL 543



 Score = 99.4 bits (246), Expect = 5e-21
 Identities = 76/272 (27%), Positives = 112/272 (41%), Gaps = 28/272 (10%)

Query: 28  LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
           L S S  C+ PP     E   + K  +  G+ V Y C+ GY      +T+  C     W 
Sbjct: 282 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--STYLHCTPQGDWS 339

Query: 88  PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
           P +     +    ++    NG  + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 340 PAAPRCEVKSCDDFLGQLPNGHVLFPLN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 397

Query: 147 VAIWSGKPPICEKVLCTPPPKIKNGK-HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGE 205
            ++W+   P+CE+  C  PP   NG  H  +++ V      + YSC          LIG 
Sbjct: 398 ESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVG---SRINYSCTTG-----HRLIGH 449

Query: 206 STIYC---GDNSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD---- 257
           S+  C   G+ + WS   P C+ + C   P + NG+          Y   V + CD    
Sbjct: 450 SSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPD 509

Query: 258 --KGFYLDGSDTIVCDS----NSTWDPPVPKC 283
               F L G  TI   S    N  W  P P+C
Sbjct: 510 RGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 71/269 (26%), Positives = 105/269 (39%), Gaps = 30/269 (11%)

Query: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
           C  PPT    +     + Y+  G  V Y C  G      F +   P +   +  D+   W
Sbjct: 158 CGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIW 217

Query: 87  LPVSDDACYRETC--PYIRDPLNGQAVPANGT-YEFGYQMHFICNEGYYLIGEEILYCEL 143
              +        C  P +    NG  V  N + +     + F C  G+ + G   + C+ 
Sbjct: 218 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274

Query: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
                 W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 275 LNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 325

Query: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
           G + ++C     WS AAP C+V  C      + NG  +  F       A V F CD+GF 
Sbjct: 326 GSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVL--FPLNLQLGAKVDFVCDEGFQ 383

Query: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVS 287
           L GS    C      S W+  VP C + S
Sbjct: 384 LKGSSASYCVLAGMESLWNSSVPVCERKS 412


>gi|4502503 complement component 4 binding protein, alpha chain
           precursor [Homo sapiens]
          Length = 597

 Score =  174 bits (441), Expect = 1e-43
 Identities = 111/318 (34%), Positives = 160/318 (50%), Gaps = 24/318 (7%)

Query: 14  WRFPGLLLAAMVL---LLYSFSDACEEPPT--FEAMELIGKPKPYYEIGERVDYKCKKGY 68
           W+    +L  M L   LL +    C  PPT  F A   I   +  ++ G  + Y C  GY
Sbjct: 26  WKVSDPILFQMTLIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGY 85

Query: 69  FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICN 128
                  T T C+ +  W  V +  C  + C +  +  NGQ V       FG Q+ F C+
Sbjct: 86  VRSHSTQTLT-CNSDGEW--VYNTFCIYKRCRHPGELRNGQ-VEIKTDLSFGSQIEFSCS 141

Query: 129 EGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVT 188
           EG++LIG     CE++     WS   P CE V C PPP I+NG+H+  E   + Y  +VT
Sbjct: 142 EGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHS-GEENFYAYGFSVT 200

Query: 189 YSCDPAPGPDPFSLIGESTIYCGDNS----VWSRAAPECKVVKCRFPVVENGKQISGFGK 244
           YSCDP      FSL+G ++I C   +    VW  + P C+ + CR P V +G+ +SGFG 
Sbjct: 201 YSCDPR-----FSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGP 255

Query: 245 KFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGYPK 304
            + YK T++F+C KGF L GS  I CD++S W+P  P C   S  +    P +S   YP+
Sbjct: 256 IYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPR 315

Query: 305 PEEGILDSLDVWVIAVIV 322
           P +      DV+V+  ++
Sbjct: 316 PTKE-----DVYVVGTVL 328



 Score = 99.8 bits (247), Expect = 3e-21
 Identities = 73/238 (30%), Positives = 107/238 (44%), Gaps = 29/238 (12%)

Query: 54  YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAV-- 111
           Y +G  + Y+C  GY       T  IC +N  W P     C    CP     LN   +  
Sbjct: 322 YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQ--GCEALCCP--EPKLNNGEITQ 377

Query: 112 -----PANG-TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPP 165
                PAN   Y +G ++ F C+E           C+  G+   WS + P C  + C  P
Sbjct: 378 HRKSRPANHCVYFYGDEISFSCHE----TSRFSAICQGDGT---WSPRTPSCGDI-CNFP 429

Query: 166 PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKV 225
           PKI +G +  S    F + + + Y CD       + L+G++ + C   S WS  AP+CK 
Sbjct: 430 PKIAHGHYKQSSSYSF-FKEEIIYECDKG-----YILVGQAKLSCS-YSHWSAPAPQCKA 482

Query: 226 VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
           + CR P + NG+ +S    ++     V  +CD G+ + G  +I C  N TW P VPKC
Sbjct: 483 L-CRKPELVNGR-LSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 42/171 (24%), Positives = 74/171 (43%), Gaps = 20/171 (11%)

Query: 54  YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
           Y  G+ + + C +   +        IC  + TW P +      + C +     +G    +
Sbjct: 389 YFYGDEISFSCHETSRF------SAICQGDGTWSPRTPSC--GDICNFPPKIAHGHYKQS 440

Query: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
           +    F  ++ + C++GY L+G+  L C    S + WS   P C K LC  P ++ NG+ 
Sbjct: 441 SSYSFFKEEIIYECDKGYILVGQAKLSC----SYSHWSAPAPQC-KALCRKP-ELVNGRL 494

Query: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECK 224
           +  + +  E  + VT  CD   G     ++G  +I C  N  W    P+C+
Sbjct: 495 SVDKDQYVEP-ENVTIQCDSGYG-----VVGPQSITCSGNRTWYPEVPKCE 539


>gi|86793109 complement receptor 1 isoform S precursor [Homo
           sapiens]
          Length = 2489

 Score =  154 bits (390), Expect = 9e-38
 Identities = 94/277 (33%), Positives = 131/277 (47%), Gaps = 13/277 (4%)

Query: 18  GLLLAAMVLLLYSFS-DACEEPPTFEAMELIGKPKPY-YEIGERVDYKCKKGYFYIPPLA 75
           G LLA +VLL    +   C  P              + + IG  ++Y+C+ GY   P   
Sbjct: 25  GSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRP--- 81

Query: 76  THTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIG 135
              IC +N  W    D  C R++C    DP+NG      G  +FG Q+ + C +GY LIG
Sbjct: 82  FSIICLKNSVWTGAKD-RCRRKSCRNPPDPVNGMVHVIKGI-QFGSQIKYSCTKGYRLIG 139

Query: 136 EEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP-A 194
                C + G   IW  + PIC+++ C  PP I NG    +  E F Y   VTY C+P +
Sbjct: 140 SSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGS 199

Query: 195 PGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVVENGKQISGFGKKFYYK 249
            G   F L+GE +IYC  N     +WS  AP+C +  KC  P VENG  +S     F   
Sbjct: 200 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLN 259

Query: 250 ATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286
             V F C  GF + G   + C + + W+P +P C +V
Sbjct: 260 EVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 296



 Score =  148 bits (374), Expect = 7e-36
 Identities = 84/239 (35%), Positives = 113/239 (47%), Gaps = 11/239 (4%)

Query: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
            + +G  ++Y+C+ GYF          C  N  W  V D+ C R++C    +P NG  V  
Sbjct: 1866 FPVGTSLNYECRPGYF---GKMFSISCLENLVWSSVEDN-CRRKSCGPPPEPFNGM-VHI 1920

Query: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
            N   +FG  +++ CNEG+ LIG     C + G+   W  K PICE + C PPP I NG  
Sbjct: 1921 NTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF 1980

Query: 174  TFSEVEVFEYLDAVTYSCDPAP-GPDPFSLIGESTIYCGDN----SVWSRAAPEC-KVVK 227
              +    F     VTY C   P G   F L+GE +IYC        VWS   P C    K
Sbjct: 1981 YSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNK 2040

Query: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286
            C  P VEN  ++ G    F     + F C  GF + GS T+ C +N  W P +P C +V
Sbjct: 2041 CTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV 2099



 Score =  147 bits (370), Expect = 2e-35
 Identities = 85/239 (35%), Positives = 119/239 (49%), Gaps = 11/239 (4%)

Query: 54  YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
           + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 513 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 567

Query: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
               + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 568 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 627

Query: 174 TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227
             +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 628 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 687

Query: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286
           C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V
Sbjct: 688 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 746



 Score =  147 bits (370), Expect = 2e-35
 Identities = 85/239 (35%), Positives = 119/239 (49%), Gaps = 11/239 (4%)

Query: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 963  FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1017

Query: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 1018 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 1077

Query: 174  TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227
              +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 1078 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1137

Query: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V
Sbjct: 1138 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 1196



 Score =  143 bits (361), Expect = 2e-34
 Identities = 84/239 (35%), Positives = 118/239 (49%), Gaps = 11/239 (4%)

Query: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 1413 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1467

Query: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 1468 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDF 1527

Query: 174  TFSEVEVFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227
              +  E F Y   VTY C+  + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 1528 ISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1587

Query: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V
Sbjct: 1588 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 1646



 Score =  132 bits (331), Expect = 6e-31
 Identities = 88/283 (31%), Positives = 128/283 (45%), Gaps = 18/283 (6%)

Query: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
            L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 1190 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 1247

Query: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
            P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 1248 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 1305

Query: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205
             ++W+   P+CE++ C  PP I NG+HT   +EVF +  AV Y+CDP P     F LIGE
Sbjct: 1306 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGE 1365

Query: 206  STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258
            STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 1366 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 1425

Query: 259  GFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASG 301
             +Y     +I C  N  W  P   C + S     K+P    +G
Sbjct: 1426 EYY-GRPFSITCLDNLVWSSPKDVCKRKS----CKTPPDPVNG 1463



 Score =  130 bits (327), Expect = 2e-30
 Identities = 87/283 (30%), Positives = 127/283 (44%), Gaps = 18/283 (6%)

Query: 28  LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
           L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 290 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 347

Query: 88  PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
           P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 348 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 405

Query: 147 VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205
            ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 406 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 465

Query: 206 STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258
           STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 466 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 525

Query: 259 GFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASG 301
            +Y     +I C  N  W  P   C + S     K+P    +G
Sbjct: 526 EYY-GRPFSITCLDNLVWSSPKDVCKRKS----CKTPPDPVNG 563



 Score =  130 bits (327), Expect = 2e-30
 Identities = 87/283 (30%), Positives = 127/283 (44%), Gaps = 18/283 (6%)

Query: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
            L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 740  LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 797

Query: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
            P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 798  PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 855

Query: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205
             ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 856  ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 915

Query: 206  STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258
            STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 916  STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 975

Query: 259  GFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASG 301
             +Y     +I C  N  W  P   C + S     K+P    +G
Sbjct: 976  EYY-GRPFSITCLDNLVWSSPKDVCKRKS----CKTPPDPVNG 1013



 Score =  124 bits (310), Expect = 2e-28
 Identities = 78/268 (29%), Positives = 120/268 (44%), Gaps = 14/268 (5%)

Query: 32   SDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91
            S  C+ PP     E     +  +  G+ V Y C+  Y      + H  C     W P + 
Sbjct: 2097 SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLH--CTPQGDWSPEAP 2154

Query: 92   DACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150
                +    ++    +G+ + P N   + G ++ F+C+EG+ L G    +C L G  A+W
Sbjct: 2155 RCTVKSCDDFLGQLPHGRVLLPLN--LQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALW 2212

Query: 151  SGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIY 209
            +   P+CE++ C  PP I NG+HT +      Y   ++Y+CD  P     F+LIGES+I 
Sbjct: 2213 NSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIR 2272

Query: 210  CGD----NSVWSRAAPECKV---VKCRF-PVVENGKQISGFGKKFYYKATVMFECDKGFY 261
            C      N VWS  AP C++     C   P ++NG  I G    +    T+ + CD G+ 
Sbjct: 2273 CTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYL 2332

Query: 262  LDGSDTIVCDSNSTWDPPVPKCLKVSTS 289
            L G   I C     W      C +V+ S
Sbjct: 2333 LVGKGFIFCTDQGIWSQLDHYCKEVNCS 2360



 Score =  115 bits (288), Expect = 6e-26
 Identities = 80/274 (29%), Positives = 122/274 (44%), Gaps = 21/274 (7%)

Query: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
            L S S  C+ PP     E     +  +  G+ V Y C+ GY      + H  C     W 
Sbjct: 1640 LPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLH--CTPQGDWS 1697

Query: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
            P +     +    ++    +G+ + P N   + G ++ F+C+EG+ L G  + +C L G 
Sbjct: 1698 PEAPRCAVKSCDDFLGQLPHGRVLFPLN--LQLGAKVSFVCDEGFRLKGSSVSHCVLVGM 1755

Query: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGE 205
             ++W+   P+CE + C  PP I NG+HT +      Y   ++Y+CDP P     F+LIGE
Sbjct: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815

Query: 206  STIYCGD----NSVWSRAAPECKVV----KCR----FPVVENGKQISGFGKKFYYKATVM 253
            STI C      N VWS  AP C++      C+    FP       I+ F  +F    ++ 
Sbjct: 1816 STIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDF--EFPVGTSLN 1873

Query: 254  FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVS 287
            +EC  G Y     +I C  N  W      C + S
Sbjct: 1874 YECRPG-YFGKMFSISCLENLVWSSVEDNCRRKS 1906



 Score =  110 bits (274), Expect = 3e-24
 Identities = 70/243 (28%), Positives = 115/243 (47%), Gaps = 21/243 (8%)

Query: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114
            ++G +V + C +G+      A+H +          S   C +  CP     LNG+     
Sbjct: 2180 QLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTP 2239

Query: 115  -GTYEFGYQMHFICNEG------YYLIGEEILYC--ELKGSVAIWSGKPPICE---KVLC 162
             G   +G ++ + C+        + LIGE  + C  + +G+  +WS   P CE      C
Sbjct: 2240 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGN-GVWSSPAPRCELSVPAAC 2298

Query: 163  TPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222
              PPKI+NG +    V ++     ++Y CDP      + L+G+  I+C D  +WS+    
Sbjct: 2299 PHPPKIQNGHYIGGHVSLYLPGMTISYICDPG-----YLLVGKGFIFCTDQGIWSQLDHY 2353

Query: 223  CKVVKCRFPVVENG--KQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPV 280
            CK V C FP+  NG  K++    K ++Y   V  +C+ G+ L+GS    C ++  WDPP+
Sbjct: 2354 CKEVNCSFPLFMNGISKELE-MKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPL 2412

Query: 281  PKC 283
             KC
Sbjct: 2413 AKC 2415



 Score = 87.8 bits (216), Expect = 1e-17
 Identities = 58/237 (24%), Positives = 90/237 (37%), Gaps = 13/237 (5%)

Query: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114
            ++G R++Y C  G+  I   +   I   N          C R  C       NG  +  N
Sbjct: 1472 QVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTN 1531

Query: 115  G-TYEFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPP 166
               + +G  + + CN G      + L+GE  +YC      V IWSG  P C       PP
Sbjct: 1532 RENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP 1591

Query: 167  KIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVV 226
             ++NG        +F   + V + C P      F + G   + C   + W    P C  V
Sbjct: 1592 NVENGILVSDNRSLFSLNEVVEFRCQPG-----FVMKGPRRVKCQALNKWEPELPSCSRV 1646

Query: 227  KCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
                P + +G+        F     V + C+ G+ L G+ ++ C     W P  P+C
Sbjct: 1647 CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC 1703



 Score = 85.1 bits (209), Expect = 9e-17
 Identities = 64/260 (24%), Positives = 98/260 (37%), Gaps = 19/260 (7%)

Query: 34   ACEEPPT-FEAMELIGKPKPYYEIGERVDYKCKKGYFYI-PPLATHTICDRNHTWLPVSD 91
            +C  PP  F  M  I     +   G  V+Y C +G+  I  P  T  +   N TW     
Sbjct: 1906 SCGPPPEPFNGMVHINTDTQF---GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTW-DKKA 1961

Query: 92   DACYRETCPYIRDPLNGQAVPANGT-YEFGYQMHFICNEG------YYLIGEEILYCELK 144
              C   +C       NG     N T +  G  + + C+ G      + L+GE  +YC  K
Sbjct: 1962 PICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSK 2021

Query: 145  GS-VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
               V +WS  PP C        P+++N          F   + + + C P      F ++
Sbjct: 2022 DDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPG-----FVMV 2076

Query: 204  GESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLD 263
            G  T+ C  N  W    P C  V    P + +G+        F     V + C+  + L 
Sbjct: 2077 GSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLR 2136

Query: 264  GSDTIVCDSNSTWDPPVPKC 283
            G+ ++ C     W P  P+C
Sbjct: 2137 GAASLHCTPQGDWSPEAPRC 2156



 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 72/265 (27%), Positives = 108/265 (40%), Gaps = 30/265 (11%)

Query: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 1516 CGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIW 1575

Query: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 1576 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1631

Query: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
              ++  W  + P C +V C PPP+I +G+HT S  + F     V YSC+P      + L 
Sbjct: 1632 --ALNKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPG-----YDLR 1683

Query: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
            G ++++C     WS  AP C V  C      + +G+ +  F       A V F CD+GF 
Sbjct: 1684 GAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVL--FPLNLQLGAKVSFVCDEGFR 1741

Query: 262  LDGSDTIVC---DSNSTWDPPVPKC 283
            L GS    C      S W+  VP C
Sbjct: 1742 LKGSSVSHCVLVGMRSLWNNSVPVC 1766



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 74/285 (25%), Positives = 112/285 (39%), Gaps = 30/285 (10%)

Query: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
           C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 166 CGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 225

Query: 87  LPVSDDACYRETC--PYIRDPLNGQAVPANGT-YEFGYQMHFICNEGYYLIGEEILYCEL 143
              +        C  P +    NG  V  N + +     + F C  G+ + G   + C+ 
Sbjct: 226 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQA 282

Query: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
                 W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 283 LNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 333

Query: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
           G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 334 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 391

Query: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVSTSSTTKSPASSASGYP 303
           L GS    C      S W+  VP C ++   S    P    +G P
Sbjct: 392 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKP 436



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 74/285 (25%), Positives = 113/285 (39%), Gaps = 30/285 (10%)

Query: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
           C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 616 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 675

Query: 87  LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143
              +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 676 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 731

Query: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
             ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 732 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 783

Query: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
           G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 784 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 841

Query: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVSTSSTTKSPASSASGYP 303
           L GS    C      S W+  VP C ++   S    P    +G P
Sbjct: 842 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKP 886



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 74/285 (25%), Positives = 113/285 (39%), Gaps = 30/285 (10%)

Query: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 1066 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 1125

Query: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 1126 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1181

Query: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
              ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 1182 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 1233

Query: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
            G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 1234 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 1291

Query: 262  LDGSDTIVC---DSNSTWDPPVPKCLKVSTSSTTKSPASSASGYP 303
            L GS    C      S W+  VP C ++   S    P    +G P
Sbjct: 1292 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKP 1336



 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 68/274 (24%), Positives = 112/274 (40%), Gaps = 30/274 (10%)

Query: 38   PPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRE 97
            PP  E   L+   +  + + E V+++C+ G+    P      C   + W P    +C R 
Sbjct: 1590 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP--RRVKCQALNKWEP-ELPSCSR- 1645

Query: 98   TCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
             C    + L+G+  P++   +  G ++ + C  GY L G   L+C  +G    WS + P 
Sbjct: 1646 VCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD---WSPEAPR 1702

Query: 157  CEKVLCTP-PPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC---GD 212
            C    C     ++ +G+  F      +    V++ CD     + F L G S  +C   G 
Sbjct: 1703 CAVKSCDDFLGQLPHGRVLFP--LNLQLGAKVSFVCD-----EGFRLKGSSVSHCVLVGM 1755

Query: 213  NSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD------KGFYLDGS 265
             S+W+ + P C+ + C   P + NG+          Y   + + CD        F L G 
Sbjct: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815

Query: 266  DTIVCDS----NSTWDPPVPKCLKVSTSSTTKSP 295
             TI C S    N  W  P P+C     +   K+P
Sbjct: 1816 STIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTP 1849



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 62/251 (24%), Positives = 100/251 (39%), Gaps = 27/251 (10%)

Query: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA- 113
            ++G +V + C +G+       +H +     +    S   C    CP     LNG+     
Sbjct: 1727 QLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTP 1786

Query: 114  NGTYEFGYQMHFICNEG------YYLIGEEILYC--ELKGSVAIWSGKPPICEKVL---- 161
            +G   +G ++ + C+        + LIGE  + C  +  G+  +WS   P CE  +    
Sbjct: 1787 SGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGN-GVWSSPAPRCELSVRAGH 1845

Query: 162  CTPPPKIKNGKHTFSEVEVFEYL--DAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRA 219
            C  P +      T   +  FE+    ++ Y C P      FS      I C +N VWS  
Sbjct: 1846 CKTPEQFPFASPTIP-INDFEFPVGTSLNYECRPGYFGKMFS------ISCLENLVWSSV 1898

Query: 220  APECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVC---DSNSTW 276
               C+   C  P  E    +        + +TV + C++GF L GS +  C    +N TW
Sbjct: 1899 EDNCRRKSCG-PPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTW 1957

Query: 277  DPPVPKCLKVS 287
            D   P C  +S
Sbjct: 1958 DKKAPICEIIS 1968


>gi|86793036 complement receptor 1 isoform F precursor [Homo
           sapiens]
          Length = 2039

 Score =  154 bits (390), Expect = 9e-38
 Identities = 94/277 (33%), Positives = 131/277 (47%), Gaps = 13/277 (4%)

Query: 18  GLLLAAMVLLLYSFS-DACEEPPTFEAMELIGKPKPY-YEIGERVDYKCKKGYFYIPPLA 75
           G LLA +VLL    +   C  P              + + IG  ++Y+C+ GY   P   
Sbjct: 25  GSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRP--- 81

Query: 76  THTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIG 135
              IC +N  W    D  C R++C    DP+NG      G  +FG Q+ + C +GY LIG
Sbjct: 82  FSIICLKNSVWTGAKD-RCRRKSCRNPPDPVNGMVHVIKGI-QFGSQIKYSCTKGYRLIG 139

Query: 136 EEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP-A 194
                C + G   IW  + PIC+++ C  PP I NG    +  E F Y   VTY C+P +
Sbjct: 140 SSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGS 199

Query: 195 PGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVVENGKQISGFGKKFYYK 249
            G   F L+GE +IYC  N     +WS  AP+C +  KC  P VENG  +S     F   
Sbjct: 200 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLN 259

Query: 250 ATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286
             V F C  GF + G   + C + + W+P +P C +V
Sbjct: 260 EVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 296



 Score =  148 bits (374), Expect = 7e-36
 Identities = 84/239 (35%), Positives = 113/239 (47%), Gaps = 11/239 (4%)

Query: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
            + +G  ++Y+C+ GYF          C  N  W  V D+ C R++C    +P NG  V  
Sbjct: 1416 FPVGTSLNYECRPGYF---GKMFSISCLENLVWSSVEDN-CRRKSCGPPPEPFNGM-VHI 1470

Query: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
            N   +FG  +++ CNEG+ LIG     C + G+   W  K PICE + C PPP I NG  
Sbjct: 1471 NTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF 1530

Query: 174  TFSEVEVFEYLDAVTYSCDPAP-GPDPFSLIGESTIYCGDN----SVWSRAAPEC-KVVK 227
              +    F     VTY C   P G   F L+GE +IYC        VWS   P C    K
Sbjct: 1531 YSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNK 1590

Query: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286
            C  P VEN  ++ G    F     + F C  GF + GS T+ C +N  W P +P C +V
Sbjct: 1591 CTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV 1649



 Score =  147 bits (370), Expect = 2e-35
 Identities = 85/239 (35%), Positives = 119/239 (49%), Gaps = 11/239 (4%)

Query: 54  YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
           + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 513 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 567

Query: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
               + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 568 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 627

Query: 174 TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227
             +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 628 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 687

Query: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286
           C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V
Sbjct: 688 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 746



 Score =  143 bits (361), Expect = 2e-34
 Identities = 84/239 (35%), Positives = 118/239 (49%), Gaps = 11/239 (4%)

Query: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 963  FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1017

Query: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 1018 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDF 1077

Query: 174  TFSEVEVFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227
              +  E F Y   VTY C+  + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 1078 ISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1137

Query: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V
Sbjct: 1138 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 1196



 Score =  132 bits (331), Expect = 6e-31
 Identities = 88/283 (31%), Positives = 128/283 (45%), Gaps = 18/283 (6%)

Query: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
            L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 740  LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 797

Query: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
            P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 798  PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 855

Query: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205
             ++W+   P+CE++ C  PP I NG+HT   +EVF +  AV Y+CDP P     F LIGE
Sbjct: 856  ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGE 915

Query: 206  STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258
            STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 916  STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 975

Query: 259  GFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASG 301
             +Y     +I C  N  W  P   C + S     K+P    +G
Sbjct: 976  EYY-GRPFSITCLDNLVWSSPKDVCKRKS----CKTPPDPVNG 1013



 Score =  130 bits (327), Expect = 2e-30
 Identities = 87/283 (30%), Positives = 127/283 (44%), Gaps = 18/283 (6%)

Query: 28  LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
           L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 290 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 347

Query: 88  PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
           P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 348 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 405

Query: 147 VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205
            ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 406 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 465

Query: 206 STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258
           STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 466 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 525

Query: 259 GFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASG 301
            +Y     +I C  N  W  P   C + S     K+P    +G
Sbjct: 526 EYY-GRPFSITCLDNLVWSSPKDVCKRKS----CKTPPDPVNG 563



 Score =  124 bits (310), Expect = 2e-28
 Identities = 78/268 (29%), Positives = 120/268 (44%), Gaps = 14/268 (5%)

Query: 32   SDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91
            S  C+ PP     E     +  +  G+ V Y C+  Y      + H  C     W P + 
Sbjct: 1647 SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLH--CTPQGDWSPEAP 1704

Query: 92   DACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150
                +    ++    +G+ + P N   + G ++ F+C+EG+ L G    +C L G  A+W
Sbjct: 1705 RCTVKSCDDFLGQLPHGRVLLPLN--LQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALW 1762

Query: 151  SGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIY 209
            +   P+CE++ C  PP I NG+HT +      Y   ++Y+CD  P     F+LIGES+I 
Sbjct: 1763 NSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIR 1822

Query: 210  CGD----NSVWSRAAPECKV---VKCRF-PVVENGKQISGFGKKFYYKATVMFECDKGFY 261
            C      N VWS  AP C++     C   P ++NG  I G    +    T+ + CD G+ 
Sbjct: 1823 CTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYL 1882

Query: 262  LDGSDTIVCDSNSTWDPPVPKCLKVSTS 289
            L G   I C     W      C +V+ S
Sbjct: 1883 LVGKGFIFCTDQGIWSQLDHYCKEVNCS 1910



 Score =  115 bits (288), Expect = 6e-26
 Identities = 80/274 (29%), Positives = 122/274 (44%), Gaps = 21/274 (7%)

Query: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
            L S S  C+ PP     E     +  +  G+ V Y C+ GY      + H  C     W 
Sbjct: 1190 LPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLH--CTPQGDWS 1247

Query: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
            P +     +    ++    +G+ + P N   + G ++ F+C+EG+ L G  + +C L G 
Sbjct: 1248 PEAPRCAVKSCDDFLGQLPHGRVLFPLN--LQLGAKVSFVCDEGFRLKGSSVSHCVLVGM 1305

Query: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGE 205
             ++W+   P+CE + C  PP I NG+HT +      Y   ++Y+CDP P     F+LIGE
Sbjct: 1306 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1365

Query: 206  STIYCGD----NSVWSRAAPECKVV----KCR----FPVVENGKQISGFGKKFYYKATVM 253
            STI C      N VWS  AP C++      C+    FP       I+ F  +F    ++ 
Sbjct: 1366 STIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDF--EFPVGTSLN 1423

Query: 254  FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVS 287
            +EC  G Y     +I C  N  W      C + S
Sbjct: 1424 YECRPG-YFGKMFSISCLENLVWSSVEDNCRRKS 1456



 Score =  110 bits (274), Expect = 3e-24
 Identities = 70/243 (28%), Positives = 115/243 (47%), Gaps = 21/243 (8%)

Query: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114
            ++G +V + C +G+      A+H +          S   C +  CP     LNG+     
Sbjct: 1730 QLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTP 1789

Query: 115  -GTYEFGYQMHFICNEG------YYLIGEEILYC--ELKGSVAIWSGKPPICE---KVLC 162
             G   +G ++ + C+        + LIGE  + C  + +G+  +WS   P CE      C
Sbjct: 1790 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGN-GVWSSPAPRCELSVPAAC 1848

Query: 163  TPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222
              PPKI+NG +    V ++     ++Y CDP      + L+G+  I+C D  +WS+    
Sbjct: 1849 PHPPKIQNGHYIGGHVSLYLPGMTISYICDPG-----YLLVGKGFIFCTDQGIWSQLDHY 1903

Query: 223  CKVVKCRFPVVENG--KQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPV 280
            CK V C FP+  NG  K++    K ++Y   V  +C+ G+ L+GS    C ++  WDPP+
Sbjct: 1904 CKEVNCSFPLFMNGISKELE-MKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPL 1962

Query: 281  PKC 283
             KC
Sbjct: 1963 AKC 1965



 Score = 87.8 bits (216), Expect = 1e-17
 Identities = 58/237 (24%), Positives = 90/237 (37%), Gaps = 13/237 (5%)

Query: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114
            ++G R++Y C  G+  I   +   I   N          C R  C       NG  +  N
Sbjct: 1022 QVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTN 1081

Query: 115  G-TYEFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPP 166
               + +G  + + CN G      + L+GE  +YC      V IWSG  P C       PP
Sbjct: 1082 RENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP 1141

Query: 167  KIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVV 226
             ++NG        +F   + V + C P      F + G   + C   + W    P C  V
Sbjct: 1142 NVENGILVSDNRSLFSLNEVVEFRCQPG-----FVMKGPRRVKCQALNKWEPELPSCSRV 1196

Query: 227  KCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
                P + +G+        F     V + C+ G+ L G+ ++ C     W P  P+C
Sbjct: 1197 CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC 1253



 Score = 85.1 bits (209), Expect = 9e-17
 Identities = 64/260 (24%), Positives = 98/260 (37%), Gaps = 19/260 (7%)

Query: 34   ACEEPPT-FEAMELIGKPKPYYEIGERVDYKCKKGYFYI-PPLATHTICDRNHTWLPVSD 91
            +C  PP  F  M  I     +   G  V+Y C +G+  I  P  T  +   N TW     
Sbjct: 1456 SCGPPPEPFNGMVHINTDTQF---GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTW-DKKA 1511

Query: 92   DACYRETCPYIRDPLNGQAVPANGT-YEFGYQMHFICNEG------YYLIGEEILYCELK 144
              C   +C       NG     N T +  G  + + C+ G      + L+GE  +YC  K
Sbjct: 1512 PICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSK 1571

Query: 145  GS-VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
               V +WS  PP C        P+++N          F   + + + C P      F ++
Sbjct: 1572 DDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPG-----FVMV 1626

Query: 204  GESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLD 263
            G  T+ C  N  W    P C  V    P + +G+        F     V + C+  + L 
Sbjct: 1627 GSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLR 1686

Query: 264  GSDTIVCDSNSTWDPPVPKC 283
            G+ ++ C     W P  P+C
Sbjct: 1687 GAASLHCTPQGDWSPEAPRC 1706



 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 72/265 (27%), Positives = 108/265 (40%), Gaps = 30/265 (11%)

Query: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 1066 CGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIW 1125

Query: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 1126 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1181

Query: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
              ++  W  + P C +V C PPP+I +G+HT S  + F     V YSC+P      + L 
Sbjct: 1182 --ALNKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPG-----YDLR 1233

Query: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
            G ++++C     WS  AP C V  C      + +G+ +  F       A V F CD+GF 
Sbjct: 1234 GAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVL--FPLNLQLGAKVSFVCDEGFR 1291

Query: 262  LDGSDTIVC---DSNSTWDPPVPKC 283
            L GS    C      S W+  VP C
Sbjct: 1292 LKGSSVSHCVLVGMRSLWNNSVPVC 1316



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 74/285 (25%), Positives = 112/285 (39%), Gaps = 30/285 (10%)

Query: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
           C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 166 CGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 225

Query: 87  LPVSDDACYRETC--PYIRDPLNGQAVPANGT-YEFGYQMHFICNEGYYLIGEEILYCEL 143
              +        C  P +    NG  V  N + +     + F C  G+ + G   + C+ 
Sbjct: 226 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQA 282

Query: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
                 W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 283 LNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 333

Query: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
           G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 334 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 391

Query: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVSTSSTTKSPASSASGYP 303
           L GS    C      S W+  VP C ++   S    P    +G P
Sbjct: 392 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKP 436



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 74/285 (25%), Positives = 113/285 (39%), Gaps = 30/285 (10%)

Query: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
           C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 616 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 675

Query: 87  LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143
              +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 676 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 731

Query: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
             ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 732 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 783

Query: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
           G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 784 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 841

Query: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVSTSSTTKSPASSASGYP 303
           L GS    C      S W+  VP C ++   S    P    +G P
Sbjct: 842 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKP 886



 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 68/274 (24%), Positives = 112/274 (40%), Gaps = 30/274 (10%)

Query: 38   PPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRE 97
            PP  E   L+   +  + + E V+++C+ G+    P      C   + W P    +C R 
Sbjct: 1140 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP--RRVKCQALNKWEP-ELPSCSR- 1195

Query: 98   TCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
             C    + L+G+  P++   +  G ++ + C  GY L G   L+C  +G    WS + P 
Sbjct: 1196 VCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD---WSPEAPR 1252

Query: 157  CEKVLCTP-PPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC---GD 212
            C    C     ++ +G+  F      +    V++ CD     + F L G S  +C   G 
Sbjct: 1253 CAVKSCDDFLGQLPHGRVLFP--LNLQLGAKVSFVCD-----EGFRLKGSSVSHCVLVGM 1305

Query: 213  NSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD------KGFYLDGS 265
             S+W+ + P C+ + C   P + NG+          Y   + + CD        F L G 
Sbjct: 1306 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1365

Query: 266  DTIVCDS----NSTWDPPVPKCLKVSTSSTTKSP 295
             TI C S    N  W  P P+C     +   K+P
Sbjct: 1366 STIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTP 1399



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 62/251 (24%), Positives = 100/251 (39%), Gaps = 27/251 (10%)

Query: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA- 113
            ++G +V + C +G+       +H +     +    S   C    CP     LNG+     
Sbjct: 1277 QLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTP 1336

Query: 114  NGTYEFGYQMHFICNEG------YYLIGEEILYC--ELKGSVAIWSGKPPICEKVL---- 161
            +G   +G ++ + C+        + LIGE  + C  +  G+  +WS   P CE  +    
Sbjct: 1337 SGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGN-GVWSSPAPRCELSVRAGH 1395

Query: 162  CTPPPKIKNGKHTFSEVEVFEYL--DAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRA 219
            C  P +      T   +  FE+    ++ Y C P      FS      I C +N VWS  
Sbjct: 1396 CKTPEQFPFASPTIP-INDFEFPVGTSLNYECRPGYFGKMFS------ISCLENLVWSSV 1448

Query: 220  APECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVC---DSNSTW 276
               C+   C  P  E    +        + +TV + C++GF L GS +  C    +N TW
Sbjct: 1449 EDNCRRKSCG-PPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTW 1507

Query: 277  DPPVPKCLKVS 287
            D   P C  +S
Sbjct: 1508 DKKAPICEIIS 1518


>gi|42544177 complement component (3d/Epstein Barr virus) receptor 2
           isoform 2 [Homo sapiens]
          Length = 1033

 Score =  138 bits (347), Expect = 9e-33
 Identities = 88/270 (32%), Positives = 127/270 (47%), Gaps = 21/270 (7%)

Query: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
           C+ PP     +   +    ++ G  + Y C  GY  +   +    C     W P      
Sbjct: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQ--CTSEGVWTPPVPQ-- 465

Query: 95  YRETCPYIRDPLNGQAVPANGTYEFGY-QMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
               C        G+ +     ++F    ++  C EGY L G   +Y E +G++  W  +
Sbjct: 466 ----CKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGS--VYQECQGTIP-WFME 518

Query: 154 PPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD 212
             +C+++ C PPP I NG HT S +E F Y   VTY+C+P P     FSLIGESTI C  
Sbjct: 519 IRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTS 578

Query: 213 NS----VWSRAAPECKV----VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDG 264
           N      WS  AP CK+    V+C    + NG +ISG    ++Y  TV F+C  GF L G
Sbjct: 579 NDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKG 638

Query: 265 SDTIVCDSNSTWDPPVPKCLKVSTSSTTKS 294
           S  I C +++TWDP +P C K +     +S
Sbjct: 639 SSQIRCKADNTWDPEIPVCEKETCQHVRQS 668



 Score =  131 bits (329), Expect = 1e-30
 Identities = 84/278 (30%), Positives = 132/278 (47%), Gaps = 26/278 (9%)

Query: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
           C         ++ GK  PY+   + V +KC  G+      ++   C  ++TW P     C
Sbjct: 602 CSHVHIANGYKISGKEAPYF-YNDTVTFKCYSGFTLKG--SSQIRCKADNTWDP-EIPVC 657

Query: 95  YRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
            +ETC ++R  L  Q +PA    E    ++  C +GY L G     C+      IW  K 
Sbjct: 658 EKETCQHVRQSL--QELPAGSRVEL---VNTSCQDGYQLTGHAYQMCQ-DAENGIWFKKI 711

Query: 155 PICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
           P+C+ + C PPP I NGKHT    E F Y + V+Y CD       F L+GE  + C  +S
Sbjct: 712 PLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG-----FYLLGEKKLQCRSDS 766

Query: 215 ----VWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
                WS  +P+C     V +C  P V++G +++     + +   V  +C+ GF ++GS 
Sbjct: 767 KGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSR 826

Query: 267 TIVCDSNSTWDPPVPKCLK---VSTSSTTKSPASSASG 301
            I C +++TW P VP C+K   +      K+P  + +G
Sbjct: 827 VIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTG 864



 Score =  111 bits (277), Expect = 1e-24
 Identities = 71/258 (27%), Positives = 105/258 (40%), Gaps = 17/258 (6%)

Query: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICD-RNHTWLPVSDDA 93
           C  PP     +  G     +  G  V Y+C +G++ +         D + H         
Sbjct: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 778

Query: 94  CYRET----CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
           C R      CP        +    +  Y     ++  CN G+ + G  ++ C    +   
Sbjct: 779 CLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT--- 835

Query: 150 WSGKPPICEK---VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGES 206
           W    P C K   + C PPPK  NG HT   +  F    ++ YSCD       + L+GE+
Sbjct: 836 WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQG-----YLLVGEA 890

Query: 207 TIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFY-YKATVMFECDKGFYLDGS 265
            + C     WS+ AP CK V C  P   +G Q     +K Y Y A V  EC+ G+ L+GS
Sbjct: 891 LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGS 950

Query: 266 DTIVCDSNSTWDPPVPKC 283
               C S+  W+PP+  C
Sbjct: 951 PQSQCQSDHQWNPPLAVC 968



 Score = 93.2 bits (230), Expect = 3e-19
 Identities = 69/256 (26%), Positives = 109/256 (42%), Gaps = 21/256 (8%)

Query: 49  KPKPYYEIGERVDYKCKKGY-FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLN 107
           K  P   +G   ++ C +GY    PP +   I  +   W  +    C    CP     LN
Sbjct: 227 KEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMP--VCEEIFCPSPPPILN 284

Query: 108 GQAVPAN-GTYEFGYQMHFICN----EG--YYLIGEEILYCELKGS-VAIWSGKPPICE- 158
           G+ +  +     +G  + + C+    EG  + LIGE  L C +       WSG  P CE 
Sbjct: 285 GRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCEL 344

Query: 159 ---KVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
               V C P P+I  G+    + + + Y D V ++C        F+L G   I C     
Sbjct: 345 STSAVQC-PHPQILRGRMVSGQKDRYTYNDTVIFACMFG-----FTLKGSKQIRCNAQGT 398

Query: 216 WSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNST 275
           W  +AP C+      P + NG++      +F    ++ + C+ G+ L G ++I C S   
Sbjct: 399 WEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGV 458

Query: 276 WDPPVPKCLKVSTSST 291
           W PPVP+C   +  +T
Sbjct: 459 WTPPVPQCKVAACEAT 474



 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 53/183 (28%), Positives = 86/183 (46%), Gaps = 19/183 (10%)

Query: 119 FGYQMHFICNEGYYLIGEEILYC--ELKGSVAIWSGKPPICEK---VLCTPPPKIKNGKH 173
           +G ++ + C++G+YL+GE+ L C  + KG  + WSG  P C +   V   P P++K+G  
Sbjct: 740 YGNEVSYECDQGFYLLGEKKLQCRSDSKGHGS-WSGPSPQCLRSPPVTRCPNPEVKHGYK 798

Query: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF--- 230
                  + + D V   C+P      F + G   I C  ++ W    P C  +K  F   
Sbjct: 799 LNKTHSAYSHNDIVYVDCNPG-----FIMNGSRVIRCHTDNTWVPGVPTC--IKKAFIGC 851

Query: 231 ---PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVS 287
              P   NG    G   +F    ++++ CD+G+ L G   ++C    TW  P P C +V+
Sbjct: 852 PPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVN 911

Query: 288 TSS 290
            SS
Sbjct: 912 CSS 914



 Score = 65.5 bits (158), Expect = 7e-11
 Identities = 54/213 (25%), Positives = 85/213 (39%), Gaps = 15/213 (7%)

Query: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV-AIWSGKPPICE---KVL 161
           LNG+    +     G  + + C+  + LIGE+ L C  K  V   W    P CE   K  
Sbjct: 30  LNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYS 89

Query: 162 CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAA- 220
             P P +  G +       + + D+VT++C        FS+ G  +++C  N++W     
Sbjct: 90  SCPEPIVPGG-YKIRGSTPYRHGDSVTFACKTN-----FSMNGNKSVWCQANNMWGPTRL 143

Query: 221 PECKVV---KC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTW 276
           P C  V   +C   P++ NG   S          +V + C+ G+ L G   I C S+  W
Sbjct: 144 PTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKW 203

Query: 277 DPPVPKCLKVSTSSTTKSPASSASGYPKPEEGI 309
               P C +    S  + P       P    G+
Sbjct: 204 SAVPPTCEEARCKSLGRFPNGKVKEPPILRVGV 236



 Score = 33.9 bits (76), Expect = 0.23
 Identities = 19/69 (27%), Positives = 31/69 (44%), Gaps = 5/69 (7%)

Query: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDS----NSTWDPPVPKCLKV 286
           P + NG+ IS +         + + C   F L G  +++C +    + TWD P PKC   
Sbjct: 27  PPILNGR-ISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYF 85

Query: 287 STSSTTKSP 295
           +  S+   P
Sbjct: 86  NKYSSCPEP 94


>gi|54792123 complement component (3d/Epstein Barr virus) receptor 2
           isoform 1 [Homo sapiens]
          Length = 1092

 Score =  137 bits (346), Expect = 1e-32
 Identities = 87/261 (33%), Positives = 124/261 (47%), Gaps = 21/261 (8%)

Query: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
           C+ PP     +   +    ++ G  + Y C  GY  +   +    C     W P      
Sbjct: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQ--CTSEGVWTPPVPQ-- 465

Query: 95  YRETCPYIRDPLNGQAVPANGTYEFGY-QMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
               C        G+ +     ++F    ++  C EGY L G   +Y E +G++  W  +
Sbjct: 466 ----CKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGS--VYQECQGTIP-WFME 518

Query: 154 PPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD 212
             +C+++ C PPP I NG HT S +E F Y   VTY+C+P P     FSLIGESTI C  
Sbjct: 519 IRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTS 578

Query: 213 NS----VWSRAAPECKV----VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDG 264
           N      WS  AP CK+    V+C    + NG +ISG    ++Y  TV F+C  GF L G
Sbjct: 579 NDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKG 638

Query: 265 SDTIVCDSNSTWDPPVPKCLK 285
           S  I C +++TWDP +P C K
Sbjct: 639 SSQIRCKADNTWDPEIPVCEK 659



 Score =  134 bits (337), Expect = 1e-31
 Identities = 87/278 (31%), Positives = 130/278 (46%), Gaps = 26/278 (9%)

Query: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
           C+ PP        G    ++  G  VDY C  GY  +   + H  C  +  W P S   C
Sbjct: 661 CQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIH--CMPSGNWSP-SAPRC 717

Query: 95  YRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
             ETC ++R  L  Q +PA    E    ++  C +GY L G     C+      IW  K 
Sbjct: 718 -EETCQHVRQSL--QELPAGSRVEL---VNTSCQDGYQLTGHAYQMCQ-DAENGIWFKKI 770

Query: 155 PICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
           P+C+ + C PPP I NGKHT    E F Y + V+Y CD       F L+GE  + C  +S
Sbjct: 771 PLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG-----FYLLGEKKLQCRSDS 825

Query: 215 ----VWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
                WS  +P+C     V +C  P V++G +++     + +   V  +C+ GF ++GS 
Sbjct: 826 KGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSR 885

Query: 267 TIVCDSNSTWDPPVPKCLK---VSTSSTTKSPASSASG 301
            I C +++TW P VP C+K   +      K+P  + +G
Sbjct: 886 VIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTG 923



 Score =  111 bits (277), Expect = 1e-24
 Identities = 71/258 (27%), Positives = 105/258 (40%), Gaps = 17/258 (6%)

Query: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICD-RNHTWLPVSDDA 93
            C  PP     +  G     +  G  V Y+C +G++ +         D + H         
Sbjct: 778  CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 837

Query: 94   CYRET----CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
            C R      CP        +    +  Y     ++  CN G+ + G  ++ C    +   
Sbjct: 838  CLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT--- 894

Query: 150  WSGKPPICEK---VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGES 206
            W    P C K   + C PPPK  NG HT   +  F    ++ YSCD       + L+GE+
Sbjct: 895  WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQG-----YLLVGEA 949

Query: 207  TIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFY-YKATVMFECDKGFYLDGS 265
             + C     WS+ AP CK V C  P   +G Q     +K Y Y A V  EC+ G+ L+GS
Sbjct: 950  LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGS 1009

Query: 266  DTIVCDSNSTWDPPVPKC 283
                C S+  W+PP+  C
Sbjct: 1010 PQSQCQSDHQWNPPLAVC 1027



 Score = 93.2 bits (230), Expect = 3e-19
 Identities = 69/256 (26%), Positives = 109/256 (42%), Gaps = 21/256 (8%)

Query: 49  KPKPYYEIGERVDYKCKKGY-FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLN 107
           K  P   +G   ++ C +GY    PP +   I  +   W  +    C    CP     LN
Sbjct: 227 KEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMP--VCEEIFCPSPPPILN 284

Query: 108 GQAVPAN-GTYEFGYQMHFICN----EG--YYLIGEEILYCELKGS-VAIWSGKPPICE- 158
           G+ +  +     +G  + + C+    EG  + LIGE  L C +       WSG  P CE 
Sbjct: 285 GRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCEL 344

Query: 159 ---KVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
               V C P P+I  G+    + + + Y D V ++C        F+L G   I C     
Sbjct: 345 STSAVQC-PHPQILRGRMVSGQKDRYTYNDTVIFACMFG-----FTLKGSKQIRCNAQGT 398

Query: 216 WSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNST 275
           W  +AP C+      P + NG++      +F    ++ + C+ G+ L G ++I C S   
Sbjct: 399 WEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGV 458

Query: 276 WDPPVPKCLKVSTSST 291
           W PPVP+C   +  +T
Sbjct: 459 WTPPVPQCKVAACEAT 474



 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 53/183 (28%), Positives = 86/183 (46%), Gaps = 19/183 (10%)

Query: 119 FGYQMHFICNEGYYLIGEEILYC--ELKGSVAIWSGKPPICEK---VLCTPPPKIKNGKH 173
           +G ++ + C++G+YL+GE+ L C  + KG  + WSG  P C +   V   P P++K+G  
Sbjct: 799 YGNEVSYECDQGFYLLGEKKLQCRSDSKGHGS-WSGPSPQCLRSPPVTRCPNPEVKHGYK 857

Query: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF--- 230
                  + + D V   C+P      F + G   I C  ++ W    P C  +K  F   
Sbjct: 858 LNKTHSAYSHNDIVYVDCNPG-----FIMNGSRVIRCHTDNTWVPGVPTC--IKKAFIGC 910

Query: 231 ---PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVS 287
              P   NG    G   +F    ++++ CD+G+ L G   ++C    TW  P P C +V+
Sbjct: 911 PPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVN 970

Query: 288 TSS 290
            SS
Sbjct: 971 CSS 973



 Score = 66.2 bits (160), Expect = 4e-11
 Identities = 49/180 (27%), Positives = 76/180 (42%), Gaps = 21/180 (11%)

Query: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPP 165
           ++G+  P    Y +   + F C  G+ L G   + C+   +   W  + P+CEK  C  P
Sbjct: 613 ISGKEAP----YFYNDTVTFKCYSGFTLKGSSQIRCKADNT---WDPEIPVCEKG-CQSP 664

Query: 166 PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKV 225
           P + +G+HT      F     V Y+CDP      + L+G  +I+C  +  WS +AP C+ 
Sbjct: 665 PGLHHGRHTGGNTVFFVSGMTVDYTCDPG-----YLLVGNKSIHCMPSGNWSPSAPRCEE 719

Query: 226 VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCD--SNSTWDPPVPKC 283
             C+   V    Q    G +      V   C  G+ L G    +C    N  W   +P C
Sbjct: 720 T-CQH--VRQSLQELPAGSRV---ELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLC 773



 Score = 65.5 bits (158), Expect = 7e-11
 Identities = 54/213 (25%), Positives = 85/213 (39%), Gaps = 15/213 (7%)

Query: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV-AIWSGKPPICE---KVL 161
           LNG+    +     G  + + C+  + LIGE+ L C  K  V   W    P CE   K  
Sbjct: 30  LNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYS 89

Query: 162 CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAA- 220
             P P +  G +       + + D+VT++C        FS+ G  +++C  N++W     
Sbjct: 90  SCPEPIVPGG-YKIRGSTPYRHGDSVTFACKTN-----FSMNGNKSVWCQANNMWGPTRL 143

Query: 221 PECKVV---KC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTW 276
           P C  V   +C   P++ NG   S          +V + C+ G+ L G   I C S+  W
Sbjct: 144 PTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKW 203

Query: 277 DPPVPKCLKVSTSSTTKSPASSASGYPKPEEGI 309
               P C +    S  + P       P    G+
Sbjct: 204 SAVPPTCEEARCKSLGRFPNGKVKEPPILRVGV 236



 Score = 33.9 bits (76), Expect = 0.23
 Identities = 19/69 (27%), Positives = 31/69 (44%), Gaps = 5/69 (7%)

Query: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDS----NSTWDPPVPKCLKV 286
           P + NG+ IS +         + + C   F L G  +++C +    + TWD P PKC   
Sbjct: 27  PPILNGR-ISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYF 85

Query: 287 STSSTTKSP 295
           +  S+   P
Sbjct: 86  NKYSSCPEP 94


>gi|148886654 polydom [Homo sapiens]
          Length = 3571

 Score =  122 bits (306), Expect = 5e-28
 Identities = 79/240 (32%), Positives = 112/240 (46%), Gaps = 30/240 (12%)

Query: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQ-AVP 112
            Y +G  V + C++GY  +    T   C  +  W             PY +    G+ A+P
Sbjct: 1805 YTVGAEVTFSCQEGYQLMG--VTKITCLESGEW---------NHLIPYCKAVSCGKPAIP 1853

Query: 113  ANGTYE-----FGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPK 167
             NG  E     FG ++ + CN+GY L G++   C    S   WS  PP+CE V C+ P  
Sbjct: 1854 ENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSS---WSHSPPVCEPVKCSSPEN 1910

Query: 168  IKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVK 227
            I NGK+  S +    YL   +YSCD       +SL G S I C  + +W RA P C +V 
Sbjct: 1911 INNGKYILSGL---TYLSTASYSCDTG-----YSLQGPSIIECTASGIWDRAPPACHLVF 1962

Query: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVS 287
            C  P       I+  G  F ++ TV + C +G+ L G DTI C ++  W     +CL VS
Sbjct: 1963 CGEPPAIKDAVIT--GNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVS 2020



 Score =  108 bits (271), Expect = 6e-24
 Identities = 85/305 (27%), Positives = 129/305 (42%), Gaps = 52/305 (17%)

Query: 16   FPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYF------ 69
            FPG  +A   +     S      PT   ++  G P P+ + G+    K  +GYF      
Sbjct: 2583 FPGFQVAGHAMQTCEESGWSSSIPTCMPIDC-GLP-PHIDFGDCTKLKDDQGYFEQEDDM 2640

Query: 70   ----YIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA--NGTYEFGYQM 123
                Y+ P   + +     TW                    N +  PA  +  + +G  +
Sbjct: 2641 MEVPYVTPHPPYHLGAVAKTWE-------------------NTKESPATHSSNFLYGTMV 2681

Query: 124  HFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEY 183
             + CN GY L+G  +L C+  G+   W+G  P C  + C  P   +NG   F+E  +   
Sbjct: 2682 SYTCNPGYELLGNPVLICQEDGT---WNGSAPSCISIECDLPTAPENGFLRFTETSMGS- 2737

Query: 184  LDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFP-VVENGKQISGF 242
              AV YSC P        L G     C +N  WS A+P C+ + C+ P  V NG   S  
Sbjct: 2738 --AVQYSCKPG-----HILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNG---SIK 2787

Query: 243  GKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGY 302
            G  + Y +T+ +ECD G+ L+G++   C  +  WD   P C+ V  S    SP  SA+G 
Sbjct: 2788 GSNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCS----SPPVSANGQ 2843

Query: 303  PKPEE 307
             + +E
Sbjct: 2844 VRGDE 2848



 Score =  105 bits (261), Expect = 8e-23
 Identities = 84/300 (28%), Positives = 122/300 (40%), Gaps = 37/300 (12%)

Query: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
            C EPP  E   ++ +     E+G  V + CK+G+    P      C  +  W   S   C
Sbjct: 2323 CPEPPLLENQLVLKELTT--EVGV-VTFSCKEGHVLQGPSVLK--CLPSQQWND-SFPVC 2376

Query: 95   YRETCPYIRDPLNGQAVPA-NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
                C     PL    VP  +    FG  + + C  G++L G     C+  G+   WS  
Sbjct: 2377 KIVLCT--PPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGT---WSSP 2431

Query: 154  PPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDN 213
             P C  V C  P +I NG     +V+   YL    Y+C P      F L+G +T  CG+N
Sbjct: 2432 LPECVPVECPQPEEIPNG---IIDVQGLAYLSTALYTCKPG-----FELVGNTTTLCGEN 2483

Query: 214  SVWSRAAPECKVVKCRFPV-VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDS 272
              W    P CK ++C  P  + NGK         +Y  TV + C++GF L+G   + C  
Sbjct: 2484 GHWLGGKPTCKAIECLKPKEILNGKFSY---TDLHYGQTVTYSCNRGFRLEGPSALTCLE 2540

Query: 273  NSTWDPPVPKCLKVSTSSTTKSPASSASGYPKP-EEGILDSLDVWVIAVIVIAIVVGVAV 331
               WD   P C  +   S            P+P E G ++  D    A+I+ +   G  V
Sbjct: 2541 TGDWDVDAPSCNAIHCDS------------PQPIENGFVEGADYSYGAIIIYSCFPGFQV 2588



 Score =  103 bits (258), Expect = 2e-22
 Identities = 73/254 (28%), Positives = 110/254 (43%), Gaps = 21/254 (8%)

Query: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA- 93
            CE+PP+     L    K  +  G  V +KC +G+  +   +    C R   W P      
Sbjct: 2083 CEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGF--VLNTSAKIECMRGGQWNPSPMSIQ 2140

Query: 94   CYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
            C    C      +NG A  +N  Y FG  + + CN+G+Y+ GE+   CE  G    WS  
Sbjct: 2141 CIPVRCGEPPSIMNGYASGSN--YSFGAMVAYSCNKGFYIKGEKKSTCEATGQ---WSSP 2195

Query: 154  PPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDN 213
             P C  V C  PPK++NG    +   +FE    V Y C+P      +  +G     C  N
Sbjct: 2196 IPTCHPVSCGEPPKVENGFLEHTTGRIFE--SEVRYQCNPG-----YKSVGSPVFVCQAN 2248

Query: 214  SVWSRAAP-ECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCD 271
              W   +P  C  + C + P ++NG      G+ F   + V F C++G+ L G  +  C 
Sbjct: 2249 RHWHSESPLMCVPLDCGKPPPIQNGFM---KGENFEVGSKVQFFCNEGYELVGDSSWTCQ 2305

Query: 272  SNSTWDPPV-PKCL 284
             +  W+    PKC+
Sbjct: 2306 KSGKWNKKSNPKCM 2319



 Score =  102 bits (254), Expect = 5e-22
 Identities = 84/286 (29%), Positives = 122/286 (42%), Gaps = 44/286 (15%)

Query: 34   ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
            +C EPP  E   L       +E    V Y+C  GY  +   +   +C  N  W   S   
Sbjct: 2203 SCGEPPKVENGFLEHTTGRIFE--SEVRYQCNPGYKSVG--SPVFVCQANRHWHSESPLM 2258

Query: 94   CYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
            C    C       NG     N  +E G ++ F CNEGY L+G+    C+  G    W+ K
Sbjct: 2259 CVPLDCGKPPPIQNGFMKGEN--FEVGSKVQFFCNEGYELVGDSSWTCQKSGK---WNKK 2313

Query: 154  P-PICEKVLCTPPPKIKNG---KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIY 209
              P C    C  PP ++N    K   +EV V      VT+SC      +   L G S + 
Sbjct: 2314 SNPKCMPAKCPEPPLLENQLVLKELTTEVGV------VTFSCK-----EGHVLQGPSVLK 2362

Query: 210  CGDNSVWSRAAPECKVVKCRFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTI 268
            C  +  W+ + P CK+V C  P ++  G  I       ++ +TV + C  GF+L G+ T 
Sbjct: 2363 CLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPS--SALHFGSTVKYSCVGGFFLRGNSTT 2420

Query: 269  VCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGYPKPEE---GILD 311
            +C  + TW  P+P+C+ V                P+PEE   GI+D
Sbjct: 2421 LCQPDGTWSSPLPECVPVEC--------------PQPEEIPNGIID 2452



 Score =  102 bits (253), Expect = 7e-22
 Identities = 70/236 (29%), Positives = 105/236 (44%), Gaps = 19/236 (8%)

Query: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLP-VSDDACYRETCPYIRDPLNGQAVP 112
            + +  +V   C +GY +       ++C  + TW P  SD++C   +C     P +G  V 
Sbjct: 3197 FSVNRQVSVSCAEGYTFEG--VNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVG 3254

Query: 113  ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGK 172
            +  T+E    + + C  GY L G     C+       WSG   IC++  C  P +  NGK
Sbjct: 3255 SKYTFES--TIIYQCEPGYELEGNRERVCQENRQ---WSGGVAICKETRCETPLEFLNGK 3309

Query: 173  HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFP- 231
               +++E       V YSC+       +SL G S  +C +N  WS   P CK   C  P 
Sbjct: 3310 ---ADIENRTTGPNVVYSCNRG-----YSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPF 3361

Query: 232  VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVS 287
            V+     +S   K+FY    V  +C +GF L G   I C+ + TW     KC K+S
Sbjct: 3362 VIPENALLSE--KEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKIS 3415



 Score = 98.6 bits (244), Expect = 8e-21
 Identities = 75/276 (27%), Positives = 112/276 (40%), Gaps = 22/276 (7%)

Query: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
            C  PP     ++ G     Y   + ++Y C +G+      A   +C  N +W   + D C
Sbjct: 2833 CSSPPVSANGQVRGDE---YTFQKEIEYTCNEGFLLEG--ARSRVCLANGSWSGATPD-C 2886

Query: 95   YRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
                C       NG  V     Y F  ++ F C+EGY L G   L C+  G+   W  + 
Sbjct: 2887 VPVRCATPPQLANG--VTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGN---WDAEI 2941

Query: 155  PICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
            P+C+ V C PP  + +G   F     F +   + Y C P      + L G S+  C  N 
Sbjct: 2942 PLCKPVNCGPPEDLAHG---FPNGFSFIHGGHIQYQCFPG-----YKLHGNSSRRCLSNG 2993

Query: 215  VWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNS 274
             WS ++P C   +C  PV+E G   +  G  F        +C KGF L G   I C+++ 
Sbjct: 2994 SWSGSSPSCLPCRCSTPVIEYG---TVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADG 3050

Query: 275  TWDPPVPKCLKVSTSSTTKSPASSASGYPKPEEGIL 310
             W    P C   S  S    P +  S     +E ++
Sbjct: 3051 QWSSGFPHCEHTSCGSLPMIPNAFISETSSWKENVI 3086



 Score = 94.7 bits (234), Expect = 1e-19
 Identities = 71/265 (26%), Positives = 105/265 (39%), Gaps = 43/265 (16%)

Query: 57   GERVDYKCKKGYFYI--PPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114
            G  V Y C  GY  +  P L    IC  + TW   S  +C    C            P N
Sbjct: 2678 GTMVSYTCNPGYELLGNPVL----ICQEDGTWNG-SAPSCISIECDL-------PTAPEN 2725

Query: 115  GTYEF-----GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIK 169
            G   F     G  + + C  G+ L G ++  C        WSG  P CE + C  P  + 
Sbjct: 2726 GFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRK---WSGASPRCEAISCKKPNPVM 2782

Query: 170  NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCR 229
            NG    S    + YL  + Y CDP      + L G     C D+  W    P C  V C 
Sbjct: 2783 NGSIKGSN---YTYLSTLYYECDPG-----YVLNGTERRTCQDDKNWDEDEPICIPVDCS 2834

Query: 230  FPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTS 289
             P V    Q+ G   ++ ++  + + C++GF L+G+ + VC +N +W    P C+ V  +
Sbjct: 2835 SPPVSANGQVRG--DEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCA 2892

Query: 290  STTKSPASSASGYPKPEEGILDSLD 314
            +            P+   G+ + LD
Sbjct: 2893 TP-----------PQLANGVTEGLD 2906



 Score = 94.4 bits (233), Expect = 1e-19
 Identities = 70/249 (28%), Positives = 105/249 (42%), Gaps = 24/249 (9%)

Query: 56   IGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANG 115
            +G  V Y CK G+      +   +C  N  W   S   C   +C      +NG    +N 
Sbjct: 2735 MGSAVQYSCKPGHILAG--SDLRLCLENRKWSGASP-RCEAISCKKPNPVMNGSIKGSNY 2791

Query: 116  TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTF 175
            TY     +++ C+ GY L G E   C+   +   W    PIC  V C+ PP   NG+   
Sbjct: 2792 TYLS--TLYYECDPGYVLNGTERRTCQDDKN---WDEDEPICIPVDCSSPPVSANGQVRG 2846

Query: 176  SEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPV-VE 234
             E   + +   + Y+C+     + F L G  +  C  N  WS A P+C  V+C  P  + 
Sbjct: 2847 DE---YTFQKEIEYTCN-----EGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLA 2898

Query: 235  NGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKS 294
            NG      G  + +   V F C +G+ L G+  + C S+  WD  +P C  V+       
Sbjct: 2899 NGVTE---GLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCG----P 2951

Query: 295  PASSASGYP 303
            P   A G+P
Sbjct: 2952 PEDLAHGFP 2960



 Score = 91.7 bits (226), Expect = 9e-19
 Identities = 69/253 (27%), Positives = 102/253 (40%), Gaps = 23/253 (9%)

Query: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
            C  PP       I  P      G  V Y C  G+F      + T+C  + TW     + C
Sbjct: 2381 CTPPPLISFGVPI--PSSALHFGSTVKYSCVGGFFLRGN--STTLCQPDGTWSSPLPE-C 2435

Query: 95   YRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
                CP   +  NG  +   G       + + C  G+ L+G     C   G    W G  
Sbjct: 2436 VPVECPQPEEIPNG-IIDVQGLAYLSTAL-YTCKPGFELVGNTTTLCGENGH---WLGGK 2490

Query: 155  PICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
            P C+ + C  P +I NGK +++++    Y   VTYSC+       F L G S + C +  
Sbjct: 2491 PTCKAIECLKPKEILNGKFSYTDLH---YGQTVTYSCNRG-----FRLEGPSALTCLETG 2542

Query: 215  VWSRAAPECKVVKCRFPV-VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSN 273
             W   AP C  + C  P  +ENG      G  + Y A +++ C  GF + G     C+  
Sbjct: 2543 DWDVDAPSCNAIHCDSPQPIENGFVE---GADYSYGAIIIYSCFPGFQVAGHAMQTCE-E 2598

Query: 274  STWDPPVPKCLKV 286
            S W   +P C+ +
Sbjct: 2599 SGWSSSIPTCMPI 2611



 Score = 79.3 bits (194), Expect = 5e-15
 Identities = 56/226 (24%), Positives = 93/226 (41%), Gaps = 54/226 (23%)

Query: 105  PLNGQAVP----ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKV 160
            P  G +VP    A+   + G +++  C+ G+ L+G  + YC  +G    W+   P CE++
Sbjct: 1632 PRLGGSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQ---WTQPLPHCERI 1688

Query: 161  LCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAA 220
             C  PP ++NG H+  +   F     VTY C+     + + L+G+S ++C DN  W+  +
Sbjct: 1689 SCGVPPPLENGFHSADD---FYAGSTVTYQCN-----NGYYLLGDSRMFCTDNGSWNGVS 1740

Query: 221  PEC------------------------KVVKCRFPVVENGKQIS---------------G 241
            P C                         +  C  P   +GK  +                
Sbjct: 1741 PSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHS 1800

Query: 242  FGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVS 287
             G+ +   A V F C +G+ L G   I C  +  W+  +P C  VS
Sbjct: 1801 SGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVS 1846



 Score = 79.3 bits (194), Expect = 5e-15
 Identities = 73/282 (25%), Positives = 103/282 (36%), Gaps = 33/282 (11%)

Query: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTI-CDRNHTWLPVSDDA 93
            C EPP  +   + G     +     V Y CK+GY         TI C  +  W   SD  
Sbjct: 1963 CGEPPAIKDAVITGNN---FTFRNTVTYTCKEGYTLA---GLDTIECLADGKWSR-SDQQ 2015

Query: 94   CYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
            C   +C     P+   A P      FG    + C++GY L     L C  +G      G+
Sbjct: 2016 CLAVSCD--EPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQ 2073

Query: 154  P-PICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGD 212
              P C    C  PP +            F     V++ C      + F L   + I C  
Sbjct: 2074 DMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKC-----MEGFVLNTSAKIECMR 2128

Query: 213  NSVW--SRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIV 269
               W  S  + +C  V+C   P + NG      G  + + A V + C+KGFY+ G     
Sbjct: 2129 GGQWNPSPMSIQCIPVRCGEPPSIMNGY---ASGSNYSFGAMVAYSCNKGFYIKGEKKST 2185

Query: 270  CDSNSTWDPPVPKCLKVSTSSTTKSPASSASGYPKPEEGILD 311
            C++   W  P+P C  VS               PK E G L+
Sbjct: 2186 CEATGQWSSPIPTCHPVSCGEP-----------PKVENGFLE 2216



 Score = 77.0 bits (188), Expect = 2e-14
 Identities = 62/235 (26%), Positives = 92/235 (39%), Gaps = 50/235 (21%)

Query: 94   CYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
            C R +C  +  PL      A+  Y  G  + + CN GYYL+G+  ++C   GS   W+G 
Sbjct: 1685 CERISCG-VPPPLENGFHSADDFYA-GSTVTYQCNNGYYLLGDSRMFCTDNGS---WNGV 1739

Query: 154  PPICEKV-----------------------------------LCTPPPKIK---NGKHTF 175
             P C  V                                    C  P K K   N ++  
Sbjct: 1740 SPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGH 1799

Query: 176  SEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVEN 235
            S  E++     VT+SC      + + L+G + I C ++  W+   P CK V C  P +  
Sbjct: 1800 SSGEIYTVGAEVTFSCQ-----EGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPE 1854

Query: 236  GKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSS 290
               I      F + + V + C+KG+ L G     C +NS+W    P C  V  SS
Sbjct: 1855 NGCIEELA--FTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSS 1907



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 70/255 (27%), Positives = 103/255 (40%), Gaps = 25/255 (9%)

Query: 34   ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
            +C +P + E   ++G     Y     + Y+C+ GY          +C  N  W       
Sbjct: 3240 SCGKPESPEHGFVVGSK---YTFESTIIYQCEPGYELEGN--RERVCQENRQWSG-GVAI 3293

Query: 94   CYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
            C    C    + LNG+A   N T   G  + + CN GY L G    +C   G+   WS  
Sbjct: 3294 CKETRCETPLEFLNGKADIENRTT--GPNVVYSCNRGYSLEGPSEAHCTENGT---WSHP 3348

Query: 154  PPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDA-VTYSCDPAPGPDPFSLIGESTIYCGD 212
             P+C+   C P P +       SE E   Y+D  V+  C      + F L G   I C  
Sbjct: 3349 VPLCKPNPC-PVPFVIPENALLSEKEF--YVDQNVSIKCR-----EGFLLQGHGIITCNP 3400

Query: 213  NSVWSRAAPECKVVKCRFPV-VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCD 271
            +  W++ + +C+ + C  P  VEN       G  + Y   + + C  G+ L+G    VC 
Sbjct: 3401 DETWTQTSAKCEKISCGPPAHVENA---IARGVHYQYGDMITYSCYSGYMLEGFLRSVCL 3457

Query: 272  SNSTWDPPVPKCLKV 286
             N TW  P P C  V
Sbjct: 3458 ENGTWTSP-PICRAV 3471



 Score = 72.4 bits (176), Expect = 6e-13
 Identities = 50/161 (31%), Positives = 71/161 (44%), Gaps = 27/161 (16%)

Query: 126 ICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLD 185
           +C EGY   G+    CEL    A+   KPP             +NG   F +     + +
Sbjct: 361 VCREGYRASGQT---CELVHCPAL---KPP-------------ENGY--FIQNTCNNHFN 399

Query: 186 AVT-YSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGK 244
           A     C P      F L+G S I C  N +WS +   C+V  C          IS   +
Sbjct: 400 AACGVRCHPG-----FDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTR 454

Query: 245 KFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
           +  YK T +  CD+G+ L+GSD + C  NS WD P P+C++
Sbjct: 455 EMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVE 495



 Score = 69.3 bits (168), Expect = 5e-12
 Identities = 47/167 (28%), Positives = 72/167 (43%), Gaps = 18/167 (10%)

Query: 144  KGSVAIWS-------GKPPICEK-VLCTPPPKIKNG-KHTFSEVEVFEYLDAVTYSCDPA 194
            KG+V  W        GK  I  K + C+  P++     H  +  E  +    V   CDP 
Sbjct: 1602 KGNVLAWPDFLSGIVGKVKIDSKSIFCSDCPRLGGSVPHLRTASEDLKPGSKVNLFCDPG 1661

Query: 195  PGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPV-VENGKQISGFGKKFYYKATVM 253
                 F L+G    YC +   W++  P C+ + C  P  +ENG   +     FY  +TV 
Sbjct: 1662 -----FQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPLENGFHSAD---DFYAGSTVT 1713

Query: 254  FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSAS 300
            ++C+ G+YL G   + C  N +W+   P CL V   +     +  AS
Sbjct: 1714 YQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHAS 1760



 Score = 69.3 bits (168), Expect = 5e-12
 Identities = 53/192 (27%), Positives = 72/192 (37%), Gaps = 33/192 (17%)

Query: 125  FICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNG-----KHTFSEVE 179
            + C  GY + G   L C  KG   +WS   P+CE + C  PP + N       HT+    
Sbjct: 3088 YSCRSGYVIQGSSDLICTEKG---VWSQPYPVCEPLSCGSPPSVANAVATGEAHTYESEV 3144

Query: 180  VFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQI 239
                L+  T   D              T  C  +  W      C   KC  P+ EN   I
Sbjct: 3145 KLRCLEGYTMDTDT------------DTFTCQKDGRWFPERISCSPKKC--PLPENITHI 3190

Query: 240  SGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSA 299
               G  F     V   C +G+  +G +  VC  + TW+PP         S  + SP S  
Sbjct: 3191 LVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPF--------SDESCSPVS-- 3240

Query: 300  SGYPK-PEEGIL 310
             G P+ PE G +
Sbjct: 3241 CGKPESPEHGFV 3252



 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 51/200 (25%), Positives = 75/200 (37%), Gaps = 29/200 (14%)

Query: 90  SDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
           S   C    CP ++ P NG  +       F       C+ G+ L+G  I+ C   G   +
Sbjct: 369 SGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNG---L 425

Query: 150 WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVT--YSCDPAPGPDPFSLIGEST 207
           WSG    C    C   P ++  KH        E L   T   +CD     + + L G   
Sbjct: 426 WSGSESYCRVRTC---PHLRQPKHGHISCSTREMLYKTTCLVACD-----EGYRLEGSDK 477

Query: 208 IYCGDNSVWSRAAPECKVVKC-RFPVVEN--------GKQISGFGKKFYYKATVMFECDK 258
           + C  NS W    P C    C  F + ++        GKQ + FG   Y        C +
Sbjct: 478 LTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICY------VSCRQ 531

Query: 259 GFYLDG-SDTIVCDSNSTWD 277
           GF L G  + + C ++  W+
Sbjct: 532 GFILSGVKEMLRCTTSGKWN 551


>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
          Length = 3667

 Score =  110 bits (274), Expect = 3e-24
 Identities = 80/259 (30%), Positives = 111/259 (42%), Gaps = 20/259 (7%)

Query: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
            Y +G+ V Y C+ GY      +    C  N TW  V    C   TCP      NG+    
Sbjct: 3149 YVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMP-TCRAVTCPTPPQISNGRLEGT 3207

Query: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
            N  +++G+ + +IC+ GY L    +L C   G+   WSG+ P C    C  P     GK 
Sbjct: 3208 N--FDWGFSISYICSPGYELSFPAVLTCVGNGT---WSGEVPQCLPKFCGDPGIPAQGKR 3262

Query: 174  TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPEC---KVVKCRF 230
               E + F Y   V++SC+      PF L+G ST  C  +  WS ++P C       C  
Sbjct: 3263 ---EGKSFIYQSEVSFSCN-----FPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCEN 3314

Query: 231  P-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTS 289
            P V  +G Q + FG  F   + V F C KG  L GS T  C  + TW    P+C+  S  
Sbjct: 3315 PGVPRHGSQNNTFG--FQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCK 3372

Query: 290  STTKSPASSASGYPKPEEG 308
                   ++  G   P  G
Sbjct: 3373 QPETPAHANVVGMDLPSHG 3391



 Score =  104 bits (259), Expect = 1e-22
 Identities = 76/272 (27%), Positives = 116/272 (42%), Gaps = 25/272 (9%)

Query: 34   ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
            +C E PT      IG    Y   G    + C  G+  +        C  +  W   S+  
Sbjct: 2718 SCGELPTPPNGNKIGTQTSY---GSTAIFTCDLGFMLVGSAVRE--CLSSGLWSE-SETR 2771

Query: 94   CYRETCPYIRDPLNGQAVPANGTYEFGYQ--MHFICNEGYYLIGEEILYCELKGSVAIWS 151
            C    C      +NGQ +  N    +GY+  + + CN G+ LIG  +  C+   +   WS
Sbjct: 2772 CLAGHCGIPELIVNGQVIGEN----YGYRDTVVYQCNPGFRLIGSSVRICQQDHN---WS 2824

Query: 152  GKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG 211
            G+ P C  V C  P     G+ + +    F + D VT+SC+       + + G +   C 
Sbjct: 2825 GQLPSCVPVSCGHPGSPIYGRTSGNG---FNFNDVVTFSCNIG-----YLMQGPTKAQCQ 2876

Query: 212  DNSVWSRAAPECKVVKCRFP-VVENGKQISGFGK-KFYYKATVMFECDKGFYLDGSDTIV 269
             N  WS   P CKVV C  P +  N K+ S      F Y   V ++C+ G++L GS  ++
Sbjct: 2877 ANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLI 2936

Query: 270  CDSNSTWDPPVPKCLKVSTSSTTKSPASSASG 301
            C  N  WD P+P+C+ +        P +  SG
Sbjct: 2937 CQPNGQWDKPLPECIMIDCGHPGVPPNAVLSG 2968



 Score =  103 bits (257), Expect = 2e-22
 Identities = 67/239 (28%), Positives = 110/239 (46%), Gaps = 17/239 (7%)

Query: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVS-DDACYRETCPYIRDPL--NGQA 110
            Y +G RV Y C  GY       T  +C  + TW   +    C   TCP I   +  +G+ 
Sbjct: 2608 YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRW 2667

Query: 111  VPANGT-YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIK 169
               NG+ YE+  ++ F C+ GY+ +G   + C   G+ + W  + P C+ + C   P   
Sbjct: 2668 RIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWS-WRNERPYCQIISCGELPTPP 2726

Query: 170  NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCR 229
            NG    ++     Y     ++CD       F L+G +   C  + +WS +   C    C 
Sbjct: 2727 NGNKIGTQT---SYGSTAIFTCDLG-----FMLVGSAVRECLSSGLWSESETRCLAGHCG 2778

Query: 230  FP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVS 287
             P ++ NG+ I   G+ + Y+ TV+++C+ GF L GS   +C  +  W   +P C+ VS
Sbjct: 2779 IPELIVNGQVI---GENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVS 2834



 Score =  102 bits (255), Expect = 4e-22
 Identities = 74/239 (30%), Positives = 106/239 (44%), Gaps = 32/239 (13%)

Query: 60   VDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGT--- 116
            V Y C +GY    P      C  N TW     + C   +C    DP     +PANG    
Sbjct: 3097 VIYSCMEGYILSGPSVRQ--CTANGTWSGTLPN-CTIISCG---DP----GIPANGLRYG 3146

Query: 117  --YEFGYQMHFICNEGYY--LIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGK 172
              Y  G  + ++C  GY   L G  I  C + G+   WSG  P C  V C  PP+I NG+
Sbjct: 3147 DDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMPTCRAVTCPTPPQISNGR 3203

Query: 173  HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFP- 231
                E   F++  +++Y C P      + L   + + C  N  WS   P+C    C  P 
Sbjct: 3204 ---LEGTNFDWGFSISYICSPG-----YELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPG 3255

Query: 232  VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSS 290
            +   GK+    GK F Y++ V F C+  F L GS T +C ++ TW    P C++ + +S
Sbjct: 3256 IPAQGKRE---GKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTS 3311



 Score = 96.3 bits (238), Expect = 4e-20
 Identities = 75/249 (30%), Positives = 101/249 (40%), Gaps = 23/249 (9%)

Query: 53   YYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD-DACYRETCPYIRDPLNGQAV 111
            +YE   +V + C  GY  + P +    C  N TW   ++   C   +C  +  P NG  +
Sbjct: 2674 HYEYKTKVVFSCDPGYHGLGPASIE--CLPNGTWSWRNERPYCQIISCGELPTPPNGNKI 2731

Query: 112  PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNG 171
                +Y  G    F C+ G+ L+G  +  C   G   +WS     C    C  P  I NG
Sbjct: 2732 GTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSG---LWSESETRCLAGHCGIPELIVNG 2786

Query: 172  KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFP 231
            +      E + Y D V Y C+P      F LIG S   C  +  WS   P C  V C  P
Sbjct: 2787 QVI---GENYGYRDTVVYQCNPG-----FRLIGSSVRICQQDHNWSGQLPSCVPVSCGHP 2838

Query: 232  VVENGKQISG--FGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTS 289
                G  I G   G  F +   V F C+ G+ + G     C +N  W  P P C KV   
Sbjct: 2839 ----GSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMC-KVVNC 2893

Query: 290  STTKSPASS 298
            S    PA+S
Sbjct: 2894 SDPGIPANS 2902



 Score = 89.4 bits (220), Expect = 5e-18
 Identities = 71/239 (29%), Positives = 97/239 (40%), Gaps = 24/239 (10%)

Query: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTW-LPVSDDACYRETCPYIRDPLNGQAVP 112
            +  G  V Y C  GYF     ++  IC  N  W  P+ +  C    C +   P N  AV 
Sbjct: 2913 FTYGTVVFYDCNPGYFLFG--SSVLICQPNGQWDKPLPE--CIMIDCGHPGVPPN--AVL 2966

Query: 113  ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE---KVLCTPPPKIK 169
            +   Y FG  +H+ C     L+G+    C+L G    WSG  P C       C  P    
Sbjct: 2967 SGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQPHCSGDATGTCGDPGTPG 3023

Query: 170  NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCR 229
            +G    S    F     V Y+CD       + L G     C  N  W+   PECK V+C 
Sbjct: 3024 HGSRQESN---FRTKSTVRYACDTG-----YILHGSEERTCLANGSWTGRQPECKAVQCG 3075

Query: 230  FP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVS 287
             P    NGK     G  F   ++V++ C +G+ L G     C +N TW   +P C  +S
Sbjct: 3076 NPGTTANGKVFRIDGTTF--SSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIIS 3132



 Score = 82.8 bits (203), Expect = 4e-16
 Identities = 71/260 (27%), Positives = 104/260 (40%), Gaps = 39/260 (15%)

Query: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNG--QAV 111
            +   + V + C  GY    P  T   C  N  W       C    C     P N   ++ 
Sbjct: 2851 FNFNDVVTFSCNIGYLMQGP--TKAQCQANRQWSH-PPPMCKVVNCSDPGIPANSKRESK 2907

Query: 112  PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLC----TPPPK 167
              +G + +G  + + CN GY+L G  +L C+  G    W    P C  + C     PP  
Sbjct: 2908 IEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQ---WDKPLPECIMIDCGHPGVPPNA 2964

Query: 168  IKNG-KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECK-- 224
            + +G K+TF           V YSC         SL+G+S+  C  N  WS + P C   
Sbjct: 2965 VLSGEKYTFGST--------VHYSCTGKR-----SLLGQSSRTCQLNGHWSGSQPHCSGD 3011

Query: 225  -VVKCRFPVV--ENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
                C  P       +Q S F  K    +TV + CD G+ L GS+   C +N +W    P
Sbjct: 3012 ATGTCGDPGTPGHGSRQESNFRTK----STVRYACDTGYILHGSEERTCLANGSWTGRQP 3067

Query: 282  KCLKVSTSSTTKSPASSASG 301
            +C  V       +P ++A+G
Sbjct: 3068 ECKAVQCG----NPGTTANG 3083



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 80/291 (27%), Positives = 115/291 (39%), Gaps = 41/291 (14%)

Query: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGY-FYIPPLATHTICDRNHTWLPVSDDA 93
            C  PP      L G     ++ G  + Y C  GY    P + T   C  N TW       
Sbjct: 3193 CPTPPQISNGRLEGTN---FDWGFSISYICSPGYELSFPAVLT---CVGNGTWSGEVPQ- 3245

Query: 94   CYRETCPYIRDPLNGQAVPANGTYE---FGYQ--MHFICNEGYYLIGEEILYCELKGSVA 148
            C  + C    DP     +PA G  E   F YQ  + F CN  + L+G     C+  G+  
Sbjct: 3246 CLPKFCG---DP----GIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGT-- 3296

Query: 149  IWSGKPPIC---EKVLCTPP--PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
             WSG  P C    +  C  P  P+  +  +TF     F+    V + C          L 
Sbjct: 3297 -WSGSSPHCIEPTQTSCENPGVPRHGSQNNTFG----FQVGSVVQFHCKKG-----HLLQ 3346

Query: 204  GESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYL- 262
            G +T  C  +  WS   PEC    C+ P       + G     +   T+++ C  GF+L 
Sbjct: 3347 GSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSH-GYTLIYTCQPGFFLA 3405

Query: 263  DGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGYPKPEEGILDSL 313
             G++  VC S++TW   VP C +  +    K P   A G P P+  + D +
Sbjct: 3406 GGTEHRVCRSDNTWTGKVPIC-EAGSKILVKDP-RPALGTPSPKLSVPDDV 3454



 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 54/215 (25%), Positives = 83/215 (38%), Gaps = 23/215 (10%)

Query: 99   CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKG-SVAIWSGKPPIC 157
            C     P +G  +   G  +    + + C+ G+ L+G+    C         W    P C
Sbjct: 2529 CSTPESPPHGYIISQTGG-QLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC 2587

Query: 158  EKVLCTPPPKIKNGKHTFSEVEVFEYL--DAVTYSCDPAPGPDPFSLIGE--STIYCGDN 213
            + + C  P    NG      +   +YL    VTY C+     D + L  +  +T  C  +
Sbjct: 2588 QAISCGIPKAPTNGG-----ILTTDYLVGTRVTYFCN-----DGYRLSSKELTTAVCQSD 2637

Query: 214  SVWSR--AAPECKVVKC---RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTI 268
              WS     P C VV C      ++E+G+     G  + YK  V+F CD G++  G  +I
Sbjct: 2638 GTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASI 2697

Query: 269  VCDSNSTWD--PPVPKCLKVSTSSTTKSPASSASG 301
             C  N TW      P C  +S       P  +  G
Sbjct: 2698 ECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIG 2732



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 63/270 (23%), Positives = 100/270 (37%), Gaps = 54/270 (20%)

Query: 99  CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV-AIWSGKPPIC 157
           CP   +P NG+ + ++  +  G  + F C+E Y L G + + C+    V A WS   P+C
Sbjct: 446 CPDPGEPENGKRIGSD--FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503

Query: 158 EKVLCTPPPKIKNGKHTF--------SEVEVFEYLDAVTYSCDPAPGPDPFSL-IGESTI 208
           +   C    +  +G  T         S  +    + AV  +       + F L IG  T+
Sbjct: 504 KVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTL 563

Query: 209 YCGD---------------------------NSVWSRAAPECKVVKCRFPVV-------- 233
             GD                           + +W     +  V    F V         
Sbjct: 564 TIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKES 623

Query: 234 --ENGKQISGF--GKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTS 289
             + G  + G   G  F  +  + FEC  GF L G  +IVC  N+ W   +P C+    S
Sbjct: 624 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 683

Query: 290 STTKSPASSASGYPKPEEGILDSLD-VWVI 318
           + T    +  S  P   EG  ++L+ +W I
Sbjct: 684 NFTAPMGTVLS--PDYPEGYGNNLNCIWTI 711



 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 33/109 (30%), Positives = 53/109 (48%), Gaps = 11/109 (10%)

Query: 218  RAAPECKVVKCR-FPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCD----S 272
            +A P     +C   P    G++I   G +F   ++V+F+C+ G+ L GS  I C+    S
Sbjct: 1828 QAVPRTSSTQCSSVPEPRFGRRI---GNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNS 1884

Query: 273  NSTWDPPVPKCLKVSTSSTTKSPASSAS-GYPKPEEGILDSLDVWVIAV 320
             + W+  +P C+       TK   +  S GYP+P +  L+   VW I V
Sbjct: 1885 LAQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNC--VWKITV 1931



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 64/256 (25%), Positives = 92/256 (35%), Gaps = 58/256 (22%)

Query: 103  RDPLNGQAVPANGTY-----EFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
            RDP     VP NGT      E G  + F C+ GY L GEE + C    +   W   PP+C
Sbjct: 1489 RDP----GVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1544

Query: 158  ----------------EKVLCTPPPKIKNGKHTFS-EVEVFEYLDAVTYSCDPA------ 194
                                  P P  ++   T +   +    L  +++S +P       
Sbjct: 1545 IAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYI 1604

Query: 195  -PGPDPFS-LIGE-------STIYCGDNSVWSRAAPECKV----------VKCRFPVVEN 235
              GPD  S LIG          I    N++      +  V           K R    + 
Sbjct: 1605 YDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDP 1664

Query: 236  GKQISG--FGKKFYYKATVMFECDKGFYLDGSDTIVC----DSNSTWDPPVPKCLKVSTS 289
            G  ++G   G  +   +TV + CD G+ L G  T+ C    D    W+  +P C     S
Sbjct: 1665 GNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGS 1724

Query: 290  STTKSPASSAS-GYPK 304
             +T S  +  S  YPK
Sbjct: 1725 RSTGSEGTVLSPNYPK 1740



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 19/65 (29%), Positives = 32/65 (49%), Gaps = 3/65 (4%)

Query: 242  FGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASS--A 299
            +G  F   +TV F CD G+ L   + ++C+ N  W  P+P C         + P+ +  +
Sbjct: 982  YGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC-DALCGGDVRGPSGTILS 1040

Query: 300  SGYPK 304
             GYP+
Sbjct: 1041 PGYPE 1045



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 35/134 (26%), Positives = 54/134 (40%), Gaps = 22/134 (16%)

Query: 195 PGPD---PFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKAT 251
           PG D    FS++ E  I    N       PE            NGK+I   G  F   +T
Sbjct: 423 PGKDNSNKFSILNEGGIKTASNLCPDPGEPE------------NGKRI---GSDFSLGST 467

Query: 252 VMFECDKGFYLDGSDTIVC----DSNSTWDPPVPKCLKVSTSSTTKSPASSASGYPKPEE 307
           V F CD+ + L G+ +I C    +  + W    P C   +  S  + P+ + +    P +
Sbjct: 468 VQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQ 527

Query: 308 GILDSLDVWVIAVI 321
              ++  VWVI  +
Sbjct: 528 YDSNAQCVWVITAV 541



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 66/276 (23%), Positives = 105/276 (38%), Gaps = 62/276 (22%)

Query: 97   ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
            ++CP  + P +G  +     Y  G  + F C++GY L G   + C + G V  W+   PI
Sbjct: 2010 DSCPEPQTPSSG--IKIGDRYMVGDVVSFQCDQGYSLQGHSHITC-MPGPVRRWNYPIPI 2066

Query: 157  C-----------EKVLCTP------PPK----------IKNGKH----TFSEVEVFEYLD 185
            C             V+ +P      P            I  G H     FS   + +YL+
Sbjct: 2067 CLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLE 2126

Query: 186  AVTYSCDPAP------GPDP----FSLIGESTIYCGDNSVWSRAAPECKVV-------KC 228
              + S + +       GP      FS   E+++Y   +S +S+      +V        C
Sbjct: 2127 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYF--HSDYSQNKQGFHIVYQAYQLQSC 2184

Query: 229  RFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCLK 285
              P    NG  I   G  F    T+ FEC  G+ L G+  + C    +  W+ P+P+C  
Sbjct: 2185 PDPRPFRNGFVI---GNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEA 2241

Query: 286  VSTSSTTKSPASSAS-GYPKPEEGILDSLDVWVIAV 320
            +   + T    +  S GYP       D    W++ V
Sbjct: 2242 LCGGNITAMNGTIYSPGYPDEYPNFQDCF--WLVRV 2275



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 60/270 (22%), Positives = 92/270 (34%), Gaps = 76/270 (28%)

Query: 54   YEIGERVDYKCKKGY--FYIPPLATHTICDRNHTW---LPVSDDAC-------------- 94
            + IG  V + C  GY   +  PL    +C++NH W   LP  D  C              
Sbjct: 986  FSIGSTVSFSCDSGYRLSHEEPL----LCEKNHWWSHPLPTCDALCGGDVRGPSGTILSP 1041

Query: 95   -YRE------TCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV 147
             Y E       C +  D  +G+ V  N      +  H   +  Y LI E   + +     
Sbjct: 1042 GYPEFYPNSLNCTWTVDVTHGKGVQFNF-----HTFHLEDHHDYLLITENGSFTQ----- 1091

Query: 148  AIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGEST 207
                   P+        PP I  G +     ++    D                    S 
Sbjct: 1092 -------PLARLTGSDLPPTINAGLYGNFRAQLRFISDF-------------------SI 1125

Query: 208  IYCGDNSVWSRAAPECKVVKCRFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
             Y G N  +S    E  +  C  P + + G +I   G  F    T+ F C  G+ L+G+ 
Sbjct: 1126 SYEGFNITFS----EYNLEPCEDPGIPQYGSRI---GFNFGIGDTLTFSCSSGYRLEGTS 1178

Query: 267  TIVC--DSNSTWDPPVPKCLKVSTSSTTKS 294
             I+C       W  P+P+C+    +S T +
Sbjct: 1179 EIICLGGGRRVWSAPLPRCVAECGASATNN 1208



 Score = 37.4 bits (85), Expect = 0.021
 Identities = 25/82 (30%), Positives = 37/82 (45%), Gaps = 6/82 (7%)

Query: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVC---DSNSTWDPPVPKCL 284
            CR P V      +G G++     TV+F+CD G+ L G + I C   ++   W P  P C+
Sbjct: 1488 CRDPGVPMNGTRNGDGRE--PGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCI 1545

Query: 285  KVSTSSTTKSPASSAS-GYPKP 305
                 + T S     S  +P P
Sbjct: 1546 APCGGNLTGSSGFILSPNFPHP 1567



 Score = 35.8 bits (81), Expect = 0.062
 Identities = 23/82 (28%), Positives = 34/82 (41%), Gaps = 5/82 (6%)

Query: 242 FGKKFYYKATVMFECDKGFYLDGSDTIVCDSNS----TWDPPVPKCLKVSTSSTTKSPAS 297
           +G +F     + + C  G+ LDG   + C +NS    +WD PVP C        T   +S
Sbjct: 150 YGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSS 209

Query: 298 SASGYPK-PEEGILDSLDVWVI 318
                P  P E   ++   W I
Sbjct: 210 GIISSPSFPNEYHNNADCTWTI 231



 Score = 35.8 bits (81), Expect = 0.062
 Identities = 19/56 (33%), Positives = 29/56 (51%), Gaps = 2/56 (3%)

Query: 107  NGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLC 162
            N + +  +  +E G  + + C  G+ L+G  IL C L G      G PP+C+ VLC
Sbjct: 2363 NAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRL-GERLQMDGAPPVCQ-VLC 2416



 Score = 32.7 bits (73), Expect = 0.52
 Identities = 26/86 (30%), Positives = 35/86 (40%), Gaps = 4/86 (4%)

Query: 77   HTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGE 136
            H+   +N     +   A   ++CP  R   NG  +     +  G  + F C  GY LIG 
Sbjct: 2162 HSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVI--GNDFTVGQTISFECFPGYTLIGN 2219

Query: 137  EILYCELKGSVAIWSGKPPICEKVLC 162
              L C L G    W+   P CE  LC
Sbjct: 2220 SALTC-LHGVSRNWNHPLPRCE-ALC 2243



 Score = 32.3 bits (72), Expect = 0.68
 Identities = 19/60 (31%), Positives = 27/60 (45%), Gaps = 3/60 (5%)

Query: 99  CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLI-GEEILYCELKGSVAIWSGKPPIC 157
           CP    P+N +    N  ++ G  +  IC EG+    G E + C L     +WSG  P C
Sbjct: 794 CPDPGIPINARRFGDN--FQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 851



 Score = 32.3 bits (72), Expect = 0.68
 Identities = 18/60 (30%), Positives = 28/60 (46%), Gaps = 3/60 (5%)

Query: 99   CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCE-LKGSVAIWSGKPPIC 157
            C  + +P  G+ +     +  G  + F CN GY L G   + CE +  S+A W+   P C
Sbjct: 1838 CSSVPEPRFGRRI--GNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC 1895


>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
            sapiens]
          Length = 3538

 Score =  110 bits (274), Expect = 3e-24
 Identities = 80/259 (30%), Positives = 111/259 (42%), Gaps = 20/259 (7%)

Query: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
            Y +G+ V Y C+ GY      +    C  N TW  V    C   TCP      NG+    
Sbjct: 3020 YVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMP-TCRAVTCPTPPQISNGRLEGT 3078

Query: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
            N  +++G+ + +IC+ GY L    +L C   G+   WSG+ P C    C  P     GK 
Sbjct: 3079 N--FDWGFSISYICSPGYELSFPAVLTCVGNGT---WSGEVPQCLPKFCGDPGIPAQGKR 3133

Query: 174  TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPEC---KVVKCRF 230
               E + F Y   V++SC+      PF L+G ST  C  +  WS ++P C       C  
Sbjct: 3134 ---EGKSFIYQSEVSFSCN-----FPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCEN 3185

Query: 231  P-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTS 289
            P V  +G Q + FG  F   + V F C KG  L GS T  C  + TW    P+C+  S  
Sbjct: 3186 PGVPRHGSQNNTFG--FQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCK 3243

Query: 290  STTKSPASSASGYPKPEEG 308
                   ++  G   P  G
Sbjct: 3244 QPETPAHANVVGMDLPSHG 3262



 Score =  104 bits (259), Expect = 1e-22
 Identities = 76/272 (27%), Positives = 116/272 (42%), Gaps = 25/272 (9%)

Query: 34   ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
            +C E PT      IG    Y   G    + C  G+  +        C  +  W   S+  
Sbjct: 2589 SCGELPTPPNGNKIGTQTSY---GSTAIFTCDLGFMLVGSAVRE--CLSSGLWSE-SETR 2642

Query: 94   CYRETCPYIRDPLNGQAVPANGTYEFGYQ--MHFICNEGYYLIGEEILYCELKGSVAIWS 151
            C    C      +NGQ +  N    +GY+  + + CN G+ LIG  +  C+   +   WS
Sbjct: 2643 CLAGHCGIPELIVNGQVIGEN----YGYRDTVVYQCNPGFRLIGSSVRICQQDHN---WS 2695

Query: 152  GKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG 211
            G+ P C  V C  P     G+ + +    F + D VT+SC+       + + G +   C 
Sbjct: 2696 GQLPSCVPVSCGHPGSPIYGRTSGNG---FNFNDVVTFSCNIG-----YLMQGPTKAQCQ 2747

Query: 212  DNSVWSRAAPECKVVKCRFP-VVENGKQISGFGK-KFYYKATVMFECDKGFYLDGSDTIV 269
             N  WS   P CKVV C  P +  N K+ S      F Y   V ++C+ G++L GS  ++
Sbjct: 2748 ANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLI 2807

Query: 270  CDSNSTWDPPVPKCLKVSTSSTTKSPASSASG 301
            C  N  WD P+P+C+ +        P +  SG
Sbjct: 2808 CQPNGQWDKPLPECIMIDCGHPGVPPNAVLSG 2839



 Score =  102 bits (255), Expect = 4e-22
 Identities = 74/239 (30%), Positives = 106/239 (44%), Gaps = 32/239 (13%)

Query: 60   VDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGT--- 116
            V Y C +GY    P      C  N TW     + C   +C    DP     +PANG    
Sbjct: 2968 VIYSCMEGYILSGPSVRQ--CTANGTWSGTLPN-CTIISCG---DP----GIPANGLRYG 3017

Query: 117  --YEFGYQMHFICNEGYY--LIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGK 172
              Y  G  + ++C  GY   L G  I  C + G+   WSG  P C  V C  PP+I NG+
Sbjct: 3018 DDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMPTCRAVTCPTPPQISNGR 3074

Query: 173  HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFP- 231
                E   F++  +++Y C P      + L   + + C  N  WS   P+C    C  P 
Sbjct: 3075 ---LEGTNFDWGFSISYICSPG-----YELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPG 3126

Query: 232  VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSS 290
            +   GK+    GK F Y++ V F C+  F L GS T +C ++ TW    P C++ + +S
Sbjct: 3127 IPAQGKRE---GKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTS 3182



 Score =  101 bits (252), Expect = 9e-22
 Identities = 76/248 (30%), Positives = 99/248 (39%), Gaps = 21/248 (8%)

Query: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVS-DDACYRETCPYIRDPLNGQAVP 112
            Y +G RV Y C  GY       T  +C  + TW   +    C   +C  +  P NG  + 
Sbjct: 2544 YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVISCGELPTPPNGNKIG 2603

Query: 113  ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGK 172
               +Y  G    F C+ G+ L+G  +  C   G   +WS     C    C  P  I NG+
Sbjct: 2604 TQTSY--GSTAIFTCDLGFMLVGSAVRECLSSG---LWSESETRCLAGHCGIPELIVNGQ 2658

Query: 173  HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPV 232
                  E + Y D V Y C+P      F LIG S   C  +  WS   P C  V C  P 
Sbjct: 2659 VI---GENYGYRDTVVYQCNPG-----FRLIGSSVRICQQDHNWSGQLPSCVPVSCGHP- 2709

Query: 233  VENGKQISG--FGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSS 290
               G  I G   G  F +   V F C+ G+ + G     C +N  W  P P C KV   S
Sbjct: 2710 ---GSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMC-KVVNCS 2765

Query: 291  TTKSPASS 298
                PA+S
Sbjct: 2766 DPGIPANS 2773



 Score = 89.4 bits (220), Expect = 5e-18
 Identities = 71/239 (29%), Positives = 97/239 (40%), Gaps = 24/239 (10%)

Query: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTW-LPVSDDACYRETCPYIRDPLNGQAVP 112
            +  G  V Y C  GYF     ++  IC  N  W  P+ +  C    C +   P N  AV 
Sbjct: 2784 FTYGTVVFYDCNPGYFLFG--SSVLICQPNGQWDKPLPE--CIMIDCGHPGVPPN--AVL 2837

Query: 113  ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE---KVLCTPPPKIK 169
            +   Y FG  +H+ C     L+G+    C+L G    WSG  P C       C  P    
Sbjct: 2838 SGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQPHCSGDATGTCGDPGTPG 2894

Query: 170  NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCR 229
            +G    S    F     V Y+CD       + L G     C  N  W+   PECK V+C 
Sbjct: 2895 HGSRQESN---FRTKSTVRYACDTG-----YILHGSEERTCLANGSWTGRQPECKAVQCG 2946

Query: 230  FP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVS 287
             P    NGK     G  F   ++V++ C +G+ L G     C +N TW   +P C  +S
Sbjct: 2947 NPGTTANGKVFRIDGTTF--SSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIIS 3003



 Score = 82.8 bits (203), Expect = 4e-16
 Identities = 71/260 (27%), Positives = 104/260 (40%), Gaps = 39/260 (15%)

Query: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNG--QAV 111
            +   + V + C  GY    P  T   C  N  W       C    C     P N   ++ 
Sbjct: 2722 FNFNDVVTFSCNIGYLMQGP--TKAQCQANRQWSH-PPPMCKVVNCSDPGIPANSKRESK 2778

Query: 112  PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLC----TPPPK 167
              +G + +G  + + CN GY+L G  +L C+  G    W    P C  + C     PP  
Sbjct: 2779 IEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQ---WDKPLPECIMIDCGHPGVPPNA 2835

Query: 168  IKNG-KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECK-- 224
            + +G K+TF           V YSC         SL+G+S+  C  N  WS + P C   
Sbjct: 2836 VLSGEKYTFGST--------VHYSCTGKR-----SLLGQSSRTCQLNGHWSGSQPHCSGD 2882

Query: 225  -VVKCRFPVV--ENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
                C  P       +Q S F  K    +TV + CD G+ L GS+   C +N +W    P
Sbjct: 2883 ATGTCGDPGTPGHGSRQESNFRTK----STVRYACDTGYILHGSEERTCLANGSWTGRQP 2938

Query: 282  KCLKVSTSSTTKSPASSASG 301
            +C  V       +P ++A+G
Sbjct: 2939 ECKAVQCG----NPGTTANG 2954



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 80/291 (27%), Positives = 115/291 (39%), Gaps = 41/291 (14%)

Query: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGY-FYIPPLATHTICDRNHTWLPVSDDA 93
            C  PP      L G     ++ G  + Y C  GY    P + T   C  N TW       
Sbjct: 3064 CPTPPQISNGRLEGTN---FDWGFSISYICSPGYELSFPAVLT---CVGNGTWSGEVPQ- 3116

Query: 94   CYRETCPYIRDPLNGQAVPANGTYE---FGYQ--MHFICNEGYYLIGEEILYCELKGSVA 148
            C  + C    DP     +PA G  E   F YQ  + F CN  + L+G     C+  G+  
Sbjct: 3117 CLPKFCG---DP----GIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGT-- 3167

Query: 149  IWSGKPPIC---EKVLCTPP--PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
             WSG  P C    +  C  P  P+  +  +TF     F+    V + C          L 
Sbjct: 3168 -WSGSSPHCIEPTQTSCENPGVPRHGSQNNTFG----FQVGSVVQFHCKKG-----HLLQ 3217

Query: 204  GESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYL- 262
            G +T  C  +  WS   PEC    C+ P       + G     +   T+++ C  GF+L 
Sbjct: 3218 GSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSH-GYTLIYTCQPGFFLA 3276

Query: 263  DGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGYPKPEEGILDSL 313
             G++  VC S++TW   VP C +  +    K P   A G P P+  + D +
Sbjct: 3277 GGTEHRVCRSDNTWTGKVPIC-EAGSKILVKDP-RPALGTPSPKLSVPDDV 3325



 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 52/194 (26%), Positives = 77/194 (39%), Gaps = 22/194 (11%)

Query: 99   CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKG-SVAIWSGKPPIC 157
            C     P +G  +   G  +    + + C+ G+ L+G+    C         W    P C
Sbjct: 2465 CSTPESPPHGYIISQTGG-QLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC 2523

Query: 158  EKVLCTPPPKIKNGKHTFSEVEVFEYL--DAVTYSCDPAPGPDPFSLIGE--STIYCGDN 213
            + + C  P    NG      +   +YL    VTY C+     D + L  +  +T  C  +
Sbjct: 2524 QAISCGIPKAPTNG-----GILTTDYLVGTRVTYFCN-----DGYRLSSKELTTAVCQSD 2573

Query: 214  SVWS--RAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVC 270
              WS     P C V+ C   P   NG +I   G +  Y +T +F CD GF L GS    C
Sbjct: 2574 GTWSNHNKTPRCVVISCGELPTPPNGNKI---GTQTSYGSTAIFTCDLGFMLVGSAVREC 2630

Query: 271  DSNSTWDPPVPKCL 284
             S+  W     +CL
Sbjct: 2631 LSSGLWSESETRCL 2644



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 63/270 (23%), Positives = 100/270 (37%), Gaps = 54/270 (20%)

Query: 99  CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV-AIWSGKPPIC 157
           CP   +P NG+ + ++  +  G  + F C+E Y L G + + C+    V A WS   P+C
Sbjct: 382 CPDPGEPENGKRIGSD--FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 439

Query: 158 EKVLCTPPPKIKNGKHTF--------SEVEVFEYLDAVTYSCDPAPGPDPFSL-IGESTI 208
           +   C    +  +G  T         S  +    + AV  +       + F L IG  T+
Sbjct: 440 KVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTL 499

Query: 209 YCGD---------------------------NSVWSRAAPECKVVKCRFPVV-------- 233
             GD                           + +W     +  V    F V         
Sbjct: 500 TIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKES 559

Query: 234 --ENGKQISGF--GKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTS 289
             + G  + G   G  F  +  + FEC  GF L G  +IVC  N+ W   +P C+    S
Sbjct: 560 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 619

Query: 290 STTKSPASSASGYPKPEEGILDSLD-VWVI 318
           + T    +  S  P   EG  ++L+ +W I
Sbjct: 620 NFTAPMGTVLS--PDYPEGYGNNLNCIWTI 647



 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 71/306 (23%), Positives = 118/306 (38%), Gaps = 60/306 (19%)

Query: 54  YEIGERVDYKCKKGYFYI--PPLATHTICDRNHTW---LPV--SDDAC---YRETCPYIR 103
           +++G+++ Y C  GY     P L          +W   +P+  ++DAC    R +   I 
Sbjct: 194 FDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGIIS 253

Query: 104 DPL--NGQAVPANGTY----EFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
            P   N     A+ T+    E G  +  I  +  + + E+  Y E++GS       P I 
Sbjct: 254 SPSFPNEYHNNADCTWTIVAEPGDTISLIFTD--FQMEEKYDYLEIEGSEP-----PTIW 306

Query: 158 EKVLCTPPPKIKN-----------GKHTF----SEVEVFEYLDAVTYSCDPAPGPD---P 199
              +  PPP I N             H +    +  +V + +D  +      PG D    
Sbjct: 307 LSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAIDFKSRGFKLFPGKDNSNK 366

Query: 200 FSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKG 259
           FS++ E  I    N       PE            NGK+I   G  F   +TV F CD+ 
Sbjct: 367 FSILNEGGIKTASNLCPDPGEPE------------NGKRI---GSDFSLGSTVQFSCDED 411

Query: 260 FYLDGSDTIVC----DSNSTWDPPVPKCLKVSTSSTTKSPASSASGYPKPEEGILDSLDV 315
           + L G+ +I C    +  + W    P C   +  S  + P+ + +    P +   ++  V
Sbjct: 412 YVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCV 471

Query: 316 WVIAVI 321
           WVI  +
Sbjct: 472 WVITAV 477



 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 33/109 (30%), Positives = 53/109 (48%), Gaps = 11/109 (10%)

Query: 218  RAAPECKVVKCR-FPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCD----S 272
            +A P     +C   P    G++I   G +F   ++V+F+C+ G+ L GS  I C+    S
Sbjct: 1764 QAVPRTSSTQCSSVPEPRFGRRI---GNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNS 1820

Query: 273  NSTWDPPVPKCLKVSTSSTTKSPASSAS-GYPKPEEGILDSLDVWVIAV 320
             + W+  +P C+       TK   +  S GYP+P +  L+   VW I V
Sbjct: 1821 LAQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNC--VWKITV 1867



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 64/256 (25%), Positives = 92/256 (35%), Gaps = 58/256 (22%)

Query: 103  RDPLNGQAVPANGTY-----EFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
            RDP     VP NGT      E G  + F C+ GY L GEE + C    +   W   PP+C
Sbjct: 1425 RDP----GVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1480

Query: 158  ----------------EKVLCTPPPKIKNGKHTFS-EVEVFEYLDAVTYSCDPA------ 194
                                  P P  ++   T +   +    L  +++S +P       
Sbjct: 1481 IAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYI 1540

Query: 195  -PGPDPFS-LIGE-------STIYCGDNSVWSRAAPECKV----------VKCRFPVVEN 235
              GPD  S LIG          I    N++      +  V           K R    + 
Sbjct: 1541 YDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDP 1600

Query: 236  GKQISG--FGKKFYYKATVMFECDKGFYLDGSDTIVC----DSNSTWDPPVPKCLKVSTS 289
            G  ++G   G  +   +TV + CD G+ L G  T+ C    D    W+  +P C     S
Sbjct: 1601 GNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGS 1660

Query: 290  STTKSPASSAS-GYPK 304
             +T S  +  S  YPK
Sbjct: 1661 RSTGSEGTVLSPNYPK 1676



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 19/65 (29%), Positives = 32/65 (49%), Gaps = 3/65 (4%)

Query: 242 FGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASS--A 299
           +G  F   +TV F CD G+ L   + ++C+ N  W  P+P C         + P+ +  +
Sbjct: 918 YGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC-DALCGGDVRGPSGTILS 976

Query: 300 SGYPK 304
            GYP+
Sbjct: 977 PGYPE 981



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 66/276 (23%), Positives = 105/276 (38%), Gaps = 62/276 (22%)

Query: 97   ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
            ++CP  + P +G  +     Y  G  + F C++GY L G   + C + G V  W+   PI
Sbjct: 1946 DSCPEPQTPSSG--IKIGDRYMVGDVVSFQCDQGYSLQGHSHITC-MPGPVRRWNYPIPI 2002

Query: 157  C-----------EKVLCTP------PPK----------IKNGKH----TFSEVEVFEYLD 185
            C             V+ +P      P            I  G H     FS   + +YL+
Sbjct: 2003 CLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLE 2062

Query: 186  AVTYSCDPAP------GPDP----FSLIGESTIYCGDNSVWSRAAPECKVV-------KC 228
              + S + +       GP      FS   E+++Y   +S +S+      +V        C
Sbjct: 2063 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYF--HSDYSQNKQGFHIVYQAYQLQSC 2120

Query: 229  RFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCLK 285
              P    NG  I   G  F    T+ FEC  G+ L G+  + C    +  W+ P+P+C  
Sbjct: 2121 PDPRPFRNGFVI---GNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEA 2177

Query: 286  VSTSSTTKSPASSAS-GYPKPEEGILDSLDVWVIAV 320
            +   + T    +  S GYP       D    W++ V
Sbjct: 2178 LCGGNITAMNGTIYSPGYPDEYPNFQDCF--WLVRV 2211



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 60/270 (22%), Positives = 92/270 (34%), Gaps = 76/270 (28%)

Query: 54   YEIGERVDYKCKKGY--FYIPPLATHTICDRNHTW---LPVSDDAC-------------- 94
            + IG  V + C  GY   +  PL    +C++NH W   LP  D  C              
Sbjct: 922  FSIGSTVSFSCDSGYRLSHEEPL----LCEKNHWWSHPLPTCDALCGGDVRGPSGTILSP 977

Query: 95   -YRE------TCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV 147
             Y E       C +  D  +G+ V  N      +  H   +  Y LI E   + +     
Sbjct: 978  GYPEFYPNSLNCTWTVDVTHGKGVQFNF-----HTFHLEDHHDYLLITENGSFTQ----- 1027

Query: 148  AIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGEST 207
                   P+        PP I  G +     ++    D                    S 
Sbjct: 1028 -------PLARLTGSDLPPTINAGLYGNFRAQLRFISDF-------------------SI 1061

Query: 208  IYCGDNSVWSRAAPECKVVKCRFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
             Y G N  +S    E  +  C  P + + G +I   G  F    T+ F C  G+ L+G+ 
Sbjct: 1062 SYEGFNITFS----EYNLEPCEDPGIPQYGSRI---GFNFGIGDTLTFSCSSGYRLEGTS 1114

Query: 267  TIVC--DSNSTWDPPVPKCLKVSTSSTTKS 294
             I+C       W  P+P+C+    +S T +
Sbjct: 1115 EIICLGGGRRVWSAPLPRCVAECGASATNN 1144



 Score = 37.4 bits (85), Expect = 0.021
 Identities = 25/82 (30%), Positives = 37/82 (45%), Gaps = 6/82 (7%)

Query: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVC---DSNSTWDPPVPKCL 284
            CR P V      +G G++     TV+F+CD G+ L G + I C   ++   W P  P C+
Sbjct: 1424 CRDPGVPMNGTRNGDGRE--PGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCI 1481

Query: 285  KVSTSSTTKSPASSAS-GYPKP 305
                 + T S     S  +P P
Sbjct: 1482 APCGGNLTGSSGFILSPNFPHP 1503



 Score = 37.4 bits (85), Expect = 0.021
 Identities = 17/42 (40%), Positives = 23/42 (54%), Gaps = 4/42 (9%)

Query: 250  ATVMFECDKGFYLDGSDTIVCDSNS----TWDPPVPKCLKVS 287
            + V + CD+GF L G  + VC  +S     WD PVP C  +S
Sbjct: 2486 SVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAIS 2527



 Score = 35.8 bits (81), Expect = 0.062
 Identities = 23/82 (28%), Positives = 34/82 (41%), Gaps = 5/82 (6%)

Query: 242 FGKKFYYKATVMFECDKGFYLDGSDTIVCDSNS----TWDPPVPKCLKVSTSSTTKSPAS 297
           +G +F     + + C  G+ LDG   + C +NS    +WD PVP C        T   +S
Sbjct: 190 YGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSS 249

Query: 298 SASGYPK-PEEGILDSLDVWVI 318
                P  P E   ++   W I
Sbjct: 250 GIISSPSFPNEYHNNADCTWTI 271



 Score = 35.8 bits (81), Expect = 0.062
 Identities = 19/56 (33%), Positives = 29/56 (51%), Gaps = 2/56 (3%)

Query: 107  NGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLC 162
            N + +  +  +E G  + + C  G+ L+G  IL C L G      G PP+C+ VLC
Sbjct: 2299 NAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRL-GERLQMDGAPPVCQ-VLC 2352



 Score = 32.7 bits (73), Expect = 0.52
 Identities = 26/86 (30%), Positives = 35/86 (40%), Gaps = 4/86 (4%)

Query: 77   HTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGE 136
            H+   +N     +   A   ++CP  R   NG  +     +  G  + F C  GY LIG 
Sbjct: 2098 HSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVI--GNDFTVGQTISFECFPGYTLIGN 2155

Query: 137  EILYCELKGSVAIWSGKPPICEKVLC 162
              L C L G    W+   P CE  LC
Sbjct: 2156 SALTC-LHGVSRNWNHPLPRCE-ALC 2179



 Score = 32.3 bits (72), Expect = 0.68
 Identities = 19/60 (31%), Positives = 27/60 (45%), Gaps = 3/60 (5%)

Query: 99  CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLI-GEEILYCELKGSVAIWSGKPPIC 157
           CP    P+N +    N  ++ G  +  IC EG+    G E + C L     +WSG  P C
Sbjct: 730 CPDPGIPINARRFGDN--FQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 787



 Score = 32.3 bits (72), Expect = 0.68
 Identities = 18/60 (30%), Positives = 28/60 (46%), Gaps = 3/60 (5%)

Query: 99   CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCE-LKGSVAIWSGKPPIC 157
            C  + +P  G+ +     +  G  + F CN GY L G   + CE +  S+A W+   P C
Sbjct: 1774 CSSVPEPRFGRRI--GNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC 1831


>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
          Length = 3707

 Score =  110 bits (274), Expect = 3e-24
 Identities = 80/259 (30%), Positives = 111/259 (42%), Gaps = 20/259 (7%)

Query: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
            Y +G+ V Y C+ GY      +    C  N TW  V    C   TCP      NG+    
Sbjct: 3189 YVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMP-TCRAVTCPTPPQISNGRLEGT 3247

Query: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
            N  +++G+ + +IC+ GY L    +L C   G+   WSG+ P C    C  P     GK 
Sbjct: 3248 N--FDWGFSISYICSPGYELSFPAVLTCVGNGT---WSGEVPQCLPKFCGDPGIPAQGKR 3302

Query: 174  TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPEC---KVVKCRF 230
               E + F Y   V++SC+      PF L+G ST  C  +  WS ++P C       C  
Sbjct: 3303 ---EGKSFIYQSEVSFSCN-----FPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCEN 3354

Query: 231  P-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTS 289
            P V  +G Q + FG  F   + V F C KG  L GS T  C  + TW    P+C+  S  
Sbjct: 3355 PGVPRHGSQNNTFG--FQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCK 3412

Query: 290  STTKSPASSASGYPKPEEG 308
                   ++  G   P  G
Sbjct: 3413 QPETPAHANVVGMDLPSHG 3431



 Score =  104 bits (259), Expect = 1e-22
 Identities = 76/272 (27%), Positives = 116/272 (42%), Gaps = 25/272 (9%)

Query: 34   ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
            +C E PT      IG    Y   G    + C  G+  +        C  +  W   S+  
Sbjct: 2758 SCGELPTPPNGNKIGTQTSY---GSTAIFTCDLGFMLVGSAVRE--CLSSGLWSE-SETR 2811

Query: 94   CYRETCPYIRDPLNGQAVPANGTYEFGYQ--MHFICNEGYYLIGEEILYCELKGSVAIWS 151
            C    C      +NGQ +  N    +GY+  + + CN G+ LIG  +  C+   +   WS
Sbjct: 2812 CLAGHCGIPELIVNGQVIGEN----YGYRDTVVYQCNPGFRLIGSSVRICQQDHN---WS 2864

Query: 152  GKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG 211
            G+ P C  V C  P     G+ + +    F + D VT+SC+       + + G +   C 
Sbjct: 2865 GQLPSCVPVSCGHPGSPIYGRTSGNG---FNFNDVVTFSCNIG-----YLMQGPTKAQCQ 2916

Query: 212  DNSVWSRAAPECKVVKCRFP-VVENGKQISGFGK-KFYYKATVMFECDKGFYLDGSDTIV 269
             N  WS   P CKVV C  P +  N K+ S      F Y   V ++C+ G++L GS  ++
Sbjct: 2917 ANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLI 2976

Query: 270  CDSNSTWDPPVPKCLKVSTSSTTKSPASSASG 301
            C  N  WD P+P+C+ +        P +  SG
Sbjct: 2977 CQPNGQWDKPLPECIMIDCGHPGVPPNAVLSG 3008



 Score =  103 bits (257), Expect = 2e-22
 Identities = 67/239 (28%), Positives = 110/239 (46%), Gaps = 17/239 (7%)

Query: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVS-DDACYRETCPYIRDPL--NGQA 110
            Y +G RV Y C  GY       T  +C  + TW   +    C   TCP I   +  +G+ 
Sbjct: 2648 YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRW 2707

Query: 111  VPANGT-YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIK 169
               NG+ YE+  ++ F C+ GY+ +G   + C   G+ + W  + P C+ + C   P   
Sbjct: 2708 RIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWS-WRNERPYCQIISCGELPTPP 2766

Query: 170  NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCR 229
            NG    ++     Y     ++CD       F L+G +   C  + +WS +   C    C 
Sbjct: 2767 NGNKIGTQT---SYGSTAIFTCDLG-----FMLVGSAVRECLSSGLWSESETRCLAGHCG 2818

Query: 230  FP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVS 287
             P ++ NG+ I   G+ + Y+ TV+++C+ GF L GS   +C  +  W   +P C+ VS
Sbjct: 2819 IPELIVNGQVI---GENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVS 2874



 Score =  102 bits (255), Expect = 4e-22
 Identities = 74/239 (30%), Positives = 106/239 (44%), Gaps = 32/239 (13%)

Query: 60   VDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGT--- 116
            V Y C +GY    P      C  N TW     + C   +C    DP     +PANG    
Sbjct: 3137 VIYSCMEGYILSGPSVRQ--CTANGTWSGTLPN-CTIISCG---DP----GIPANGLRYG 3186

Query: 117  --YEFGYQMHFICNEGYY--LIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGK 172
              Y  G  + ++C  GY   L G  I  C + G+   WSG  P C  V C  PP+I NG+
Sbjct: 3187 DDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMPTCRAVTCPTPPQISNGR 3243

Query: 173  HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFP- 231
                E   F++  +++Y C P      + L   + + C  N  WS   P+C    C  P 
Sbjct: 3244 ---LEGTNFDWGFSISYICSPG-----YELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPG 3295

Query: 232  VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSS 290
            +   GK+    GK F Y++ V F C+  F L GS T +C ++ TW    P C++ + +S
Sbjct: 3296 IPAQGKRE---GKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTS 3351



 Score = 96.3 bits (238), Expect = 4e-20
 Identities = 75/249 (30%), Positives = 101/249 (40%), Gaps = 23/249 (9%)

Query: 53   YYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD-DACYRETCPYIRDPLNGQAV 111
            +YE   +V + C  GY  + P +    C  N TW   ++   C   +C  +  P NG  +
Sbjct: 2714 HYEYKTKVVFSCDPGYHGLGPASIE--CLPNGTWSWRNERPYCQIISCGELPTPPNGNKI 2771

Query: 112  PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNG 171
                +Y  G    F C+ G+ L+G  +  C   G   +WS     C    C  P  I NG
Sbjct: 2772 GTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSG---LWSESETRCLAGHCGIPELIVNG 2826

Query: 172  KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFP 231
            +      E + Y D V Y C+P      F LIG S   C  +  WS   P C  V C  P
Sbjct: 2827 QVI---GENYGYRDTVVYQCNPG-----FRLIGSSVRICQQDHNWSGQLPSCVPVSCGHP 2878

Query: 232  VVENGKQISG--FGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTS 289
                G  I G   G  F +   V F C+ G+ + G     C +N  W  P P C KV   
Sbjct: 2879 ----GSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMC-KVVNC 2933

Query: 290  STTKSPASS 298
            S    PA+S
Sbjct: 2934 SDPGIPANS 2942



 Score = 89.4 bits (220), Expect = 5e-18
 Identities = 71/239 (29%), Positives = 97/239 (40%), Gaps = 24/239 (10%)

Query: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTW-LPVSDDACYRETCPYIRDPLNGQAVP 112
            +  G  V Y C  GYF     ++  IC  N  W  P+ +  C    C +   P N  AV 
Sbjct: 2953 FTYGTVVFYDCNPGYFLFG--SSVLICQPNGQWDKPLPE--CIMIDCGHPGVPPN--AVL 3006

Query: 113  ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE---KVLCTPPPKIK 169
            +   Y FG  +H+ C     L+G+    C+L G    WSG  P C       C  P    
Sbjct: 3007 SGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQPHCSGDATGTCGDPGTPG 3063

Query: 170  NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCR 229
            +G    S    F     V Y+CD       + L G     C  N  W+   PECK V+C 
Sbjct: 3064 HGSRQESN---FRTKSTVRYACDTG-----YILHGSEERTCLANGSWTGRQPECKAVQCG 3115

Query: 230  FP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVS 287
             P    NGK     G  F   ++V++ C +G+ L G     C +N TW   +P C  +S
Sbjct: 3116 NPGTTANGKVFRIDGTTF--SSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIIS 3172



 Score = 82.8 bits (203), Expect = 4e-16
 Identities = 71/260 (27%), Positives = 104/260 (40%), Gaps = 39/260 (15%)

Query: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNG--QAV 111
            +   + V + C  GY    P  T   C  N  W       C    C     P N   ++ 
Sbjct: 2891 FNFNDVVTFSCNIGYLMQGP--TKAQCQANRQWSH-PPPMCKVVNCSDPGIPANSKRESK 2947

Query: 112  PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLC----TPPPK 167
              +G + +G  + + CN GY+L G  +L C+  G    W    P C  + C     PP  
Sbjct: 2948 IEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQ---WDKPLPECIMIDCGHPGVPPNA 3004

Query: 168  IKNG-KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECK-- 224
            + +G K+TF           V YSC         SL+G+S+  C  N  WS + P C   
Sbjct: 3005 VLSGEKYTFGST--------VHYSCTGKR-----SLLGQSSRTCQLNGHWSGSQPHCSGD 3051

Query: 225  -VVKCRFPVV--ENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
                C  P       +Q S F  K    +TV + CD G+ L GS+   C +N +W    P
Sbjct: 3052 ATGTCGDPGTPGHGSRQESNFRTK----STVRYACDTGYILHGSEERTCLANGSWTGRQP 3107

Query: 282  KCLKVSTSSTTKSPASSASG 301
            +C  V       +P ++A+G
Sbjct: 3108 ECKAVQCG----NPGTTANG 3123



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 80/291 (27%), Positives = 115/291 (39%), Gaps = 41/291 (14%)

Query: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGY-FYIPPLATHTICDRNHTWLPVSDDA 93
            C  PP      L G     ++ G  + Y C  GY    P + T   C  N TW       
Sbjct: 3233 CPTPPQISNGRLEGTN---FDWGFSISYICSPGYELSFPAVLT---CVGNGTWSGEVPQ- 3285

Query: 94   CYRETCPYIRDPLNGQAVPANGTYE---FGYQ--MHFICNEGYYLIGEEILYCELKGSVA 148
            C  + C    DP     +PA G  E   F YQ  + F CN  + L+G     C+  G+  
Sbjct: 3286 CLPKFCG---DP----GIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGT-- 3336

Query: 149  IWSGKPPIC---EKVLCTPP--PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
             WSG  P C    +  C  P  P+  +  +TF     F+    V + C          L 
Sbjct: 3337 -WSGSSPHCIEPTQTSCENPGVPRHGSQNNTFG----FQVGSVVQFHCKKG-----HLLQ 3386

Query: 204  GESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYL- 262
            G +T  C  +  WS   PEC    C+ P       + G     +   T+++ C  GF+L 
Sbjct: 3387 GSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSH-GYTLIYTCQPGFFLA 3445

Query: 263  DGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGYPKPEEGILDSL 313
             G++  VC S++TW   VP C +  +    K P   A G P P+  + D +
Sbjct: 3446 GGTEHRVCRSDNTWTGKVPIC-EAGSKILVKDP-RPALGTPSPKLSVPDDV 3494



 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 54/215 (25%), Positives = 83/215 (38%), Gaps = 23/215 (10%)

Query: 99   CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKG-SVAIWSGKPPIC 157
            C     P +G  +   G  +    + + C+ G+ L+G+    C         W    P C
Sbjct: 2569 CSTPESPPHGYIISQTGG-QLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC 2627

Query: 158  EKVLCTPPPKIKNGKHTFSEVEVFEYL--DAVTYSCDPAPGPDPFSLIGE--STIYCGDN 213
            + + C  P    NG      +   +YL    VTY C+     D + L  +  +T  C  +
Sbjct: 2628 QAISCGIPKAPTNGG-----ILTTDYLVGTRVTYFCN-----DGYRLSSKELTTAVCQSD 2677

Query: 214  SVWSR--AAPECKVVKC---RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTI 268
              WS     P C VV C      ++E+G+     G  + YK  V+F CD G++  G  +I
Sbjct: 2678 GTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASI 2737

Query: 269  VCDSNSTWD--PPVPKCLKVSTSSTTKSPASSASG 301
             C  N TW      P C  +S       P  +  G
Sbjct: 2738 ECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIG 2772



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 63/270 (23%), Positives = 100/270 (37%), Gaps = 54/270 (20%)

Query: 99  CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV-AIWSGKPPIC 157
           CP   +P NG+ + ++  +  G  + F C+E Y L G + + C+    V A WS   P+C
Sbjct: 486 CPDPGEPENGKRIGSD--FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 543

Query: 158 EKVLCTPPPKIKNGKHTF--------SEVEVFEYLDAVTYSCDPAPGPDPFSL-IGESTI 208
           +   C    +  +G  T         S  +    + AV  +       + F L IG  T+
Sbjct: 544 KVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTL 603

Query: 209 YCGD---------------------------NSVWSRAAPECKVVKCRFPVV-------- 233
             GD                           + +W     +  V    F V         
Sbjct: 604 TIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKES 663

Query: 234 --ENGKQISGF--GKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTS 289
             + G  + G   G  F  +  + FEC  GF L G  +IVC  N+ W   +P C+    S
Sbjct: 664 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 723

Query: 290 STTKSPASSASGYPKPEEGILDSLD-VWVI 318
           + T    +  S  P   EG  ++L+ +W I
Sbjct: 724 NFTAPMGTVLS--PDYPEGYGNNLNCIWTI 751



 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 33/109 (30%), Positives = 53/109 (48%), Gaps = 11/109 (10%)

Query: 218  RAAPECKVVKCR-FPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCD----S 272
            +A P     +C   P    G++I   G +F   ++V+F+C+ G+ L GS  I C+    S
Sbjct: 1868 QAVPRTSSTQCSSVPEPRFGRRI---GNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNS 1924

Query: 273  NSTWDPPVPKCLKVSTSSTTKSPASSAS-GYPKPEEGILDSLDVWVIAV 320
             + W+  +P C+       TK   +  S GYP+P +  L+   VW I V
Sbjct: 1925 LAQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNC--VWKITV 1971



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 64/256 (25%), Positives = 92/256 (35%), Gaps = 58/256 (22%)

Query: 103  RDPLNGQAVPANGTY-----EFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
            RDP     VP NGT      E G  + F C+ GY L GEE + C    +   W   PP+C
Sbjct: 1529 RDP----GVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1584

Query: 158  ----------------EKVLCTPPPKIKNGKHTFS-EVEVFEYLDAVTYSCDPA------ 194
                                  P P  ++   T +   +    L  +++S +P       
Sbjct: 1585 IAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYI 1644

Query: 195  -PGPDPFS-LIGE-------STIYCGDNSVWSRAAPECKV----------VKCRFPVVEN 235
              GPD  S LIG          I    N++      +  V           K R    + 
Sbjct: 1645 YDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDP 1704

Query: 236  GKQISG--FGKKFYYKATVMFECDKGFYLDGSDTIVC----DSNSTWDPPVPKCLKVSTS 289
            G  ++G   G  +   +TV + CD G+ L G  T+ C    D    W+  +P C     S
Sbjct: 1705 GNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGS 1764

Query: 290  STTKSPASSAS-GYPK 304
             +T S  +  S  YPK
Sbjct: 1765 RSTGSEGTVLSPNYPK 1780



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 19/65 (29%), Positives = 32/65 (49%), Gaps = 3/65 (4%)

Query: 242  FGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASS--A 299
            +G  F   +TV F CD G+ L   + ++C+ N  W  P+P C         + P+ +  +
Sbjct: 1022 YGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC-DALCGGDVRGPSGTILS 1080

Query: 300  SGYPK 304
             GYP+
Sbjct: 1081 PGYPE 1085



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 35/134 (26%), Positives = 54/134 (40%), Gaps = 22/134 (16%)

Query: 195 PGPD---PFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKAT 251
           PG D    FS++ E  I    N       PE            NGK+I   G  F   +T
Sbjct: 463 PGKDNSNKFSILNEGGIKTASNLCPDPGEPE------------NGKRI---GSDFSLGST 507

Query: 252 VMFECDKGFYLDGSDTIVC----DSNSTWDPPVPKCLKVSTSSTTKSPASSASGYPKPEE 307
           V F CD+ + L G+ +I C    +  + W    P C   +  S  + P+ + +    P +
Sbjct: 508 VQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQ 567

Query: 308 GILDSLDVWVIAVI 321
              ++  VWVI  +
Sbjct: 568 YDSNAQCVWVITAV 581



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 66/276 (23%), Positives = 105/276 (38%), Gaps = 62/276 (22%)

Query: 97   ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
            ++CP  + P +G  +     Y  G  + F C++GY L G   + C + G V  W+   PI
Sbjct: 2050 DSCPEPQTPSSG--IKIGDRYMVGDVVSFQCDQGYSLQGHSHITC-MPGPVRRWNYPIPI 2106

Query: 157  C-----------EKVLCTP------PPK----------IKNGKH----TFSEVEVFEYLD 185
            C             V+ +P      P            I  G H     FS   + +YL+
Sbjct: 2107 CLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLE 2166

Query: 186  AVTYSCDPAP------GPDP----FSLIGESTIYCGDNSVWSRAAPECKVV-------KC 228
              + S + +       GP      FS   E+++Y   +S +S+      +V        C
Sbjct: 2167 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYF--HSDYSQNKQGFHIVYQAYQLQSC 2224

Query: 229  RFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCLK 285
              P    NG  I   G  F    T+ FEC  G+ L G+  + C    +  W+ P+P+C  
Sbjct: 2225 PDPRPFRNGFVI---GNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEA 2281

Query: 286  VSTSSTTKSPASSAS-GYPKPEEGILDSLDVWVIAV 320
            +   + T    +  S GYP       D    W++ V
Sbjct: 2282 LCGGNITAMNGTIYSPGYPDEYPNFQDCF--WLVRV 2315



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 60/270 (22%), Positives = 92/270 (34%), Gaps = 76/270 (28%)

Query: 54   YEIGERVDYKCKKGY--FYIPPLATHTICDRNHTW---LPVSDDAC-------------- 94
            + IG  V + C  GY   +  PL    +C++NH W   LP  D  C              
Sbjct: 1026 FSIGSTVSFSCDSGYRLSHEEPL----LCEKNHWWSHPLPTCDALCGGDVRGPSGTILSP 1081

Query: 95   -YRE------TCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV 147
             Y E       C +  D  +G+ V  N      +  H   +  Y LI E   + +     
Sbjct: 1082 GYPEFYPNSLNCTWTVDVTHGKGVQFNF-----HTFHLEDHHDYLLITENGSFTQ----- 1131

Query: 148  AIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGEST 207
                   P+        PP I  G +     ++    D                    S 
Sbjct: 1132 -------PLARLTGSDLPPTINAGLYGNFRAQLRFISDF-------------------SI 1165

Query: 208  IYCGDNSVWSRAAPECKVVKCRFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
             Y G N  +S    E  +  C  P + + G +I   G  F    T+ F C  G+ L+G+ 
Sbjct: 1166 SYEGFNITFS----EYNLEPCEDPGIPQYGSRI---GFNFGIGDTLTFSCSSGYRLEGTS 1218

Query: 267  TIVC--DSNSTWDPPVPKCLKVSTSSTTKS 294
             I+C       W  P+P+C+    +S T +
Sbjct: 1219 EIICLGGGRRVWSAPLPRCVAECGASATNN 1248



 Score = 37.4 bits (85), Expect = 0.021
 Identities = 25/82 (30%), Positives = 37/82 (45%), Gaps = 6/82 (7%)

Query: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVC---DSNSTWDPPVPKCL 284
            CR P V      +G G++     TV+F+CD G+ L G + I C   ++   W P  P C+
Sbjct: 1528 CRDPGVPMNGTRNGDGRE--PGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCI 1585

Query: 285  KVSTSSTTKSPASSAS-GYPKP 305
                 + T S     S  +P P
Sbjct: 1586 APCGGNLTGSSGFILSPNFPHP 1607



 Score = 35.8 bits (81), Expect = 0.062
 Identities = 23/82 (28%), Positives = 34/82 (41%), Gaps = 5/82 (6%)

Query: 242 FGKKFYYKATVMFECDKGFYLDGSDTIVCDSNS----TWDPPVPKCLKVSTSSTTKSPAS 297
           +G +F     + + C  G+ LDG   + C +NS    +WD PVP C        T   +S
Sbjct: 190 YGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSS 249

Query: 298 SASGYPK-PEEGILDSLDVWVI 318
                P  P E   ++   W I
Sbjct: 250 GIISSPSFPNEYHNNADCTWTI 271



 Score = 35.8 bits (81), Expect = 0.062
 Identities = 19/56 (33%), Positives = 29/56 (51%), Gaps = 2/56 (3%)

Query: 107  NGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLC 162
            N + +  +  +E G  + + C  G+ L+G  IL C L G      G PP+C+ VLC
Sbjct: 2403 NAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRL-GERLQMDGAPPVCQ-VLC 2456



 Score = 32.7 bits (73), Expect = 0.52
 Identities = 26/86 (30%), Positives = 35/86 (40%), Gaps = 4/86 (4%)

Query: 77   HTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGE 136
            H+   +N     +   A   ++CP  R   NG  +     +  G  + F C  GY LIG 
Sbjct: 2202 HSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVI--GNDFTVGQTISFECFPGYTLIGN 2259

Query: 137  EILYCELKGSVAIWSGKPPICEKVLC 162
              L C L G    W+   P CE  LC
Sbjct: 2260 SALTC-LHGVSRNWNHPLPRCE-ALC 2283



 Score = 32.3 bits (72), Expect = 0.68
 Identities = 19/60 (31%), Positives = 27/60 (45%), Gaps = 3/60 (5%)

Query: 99  CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLI-GEEILYCELKGSVAIWSGKPPIC 157
           CP    P+N +    N  ++ G  +  IC EG+    G E + C L     +WSG  P C
Sbjct: 834 CPDPGIPINARRFGDN--FQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 891



 Score = 32.3 bits (72), Expect = 0.68
 Identities = 18/60 (30%), Positives = 28/60 (46%), Gaps = 3/60 (5%)

Query: 99   CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCE-LKGSVAIWSGKPPIC 157
            C  + +P  G+ +     +  G  + F CN GY L G   + CE +  S+A W+   P C
Sbjct: 1878 CSSVPEPRFGRRI--GNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC 1935


>gi|153266841 apolipoprotein H precursor [Homo sapiens]
          Length = 345

 Score =  108 bits (271), Expect = 6e-24
 Identities = 75/242 (30%), Positives = 106/242 (43%), Gaps = 28/242 (11%)

Query: 51  KPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQA 110
           K +YE GE + Y CK GY     +    IC     W P++   C    CP+     NG  
Sbjct: 38  KTFYEPGEEITYSCKPGYVSRGGMRKF-ICPLTGLW-PINTLKCTPRVCPFAGILENGAV 95

Query: 111 VPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKN 170
                T+E+   + F CN G+YL G +   C  +G    WS + P+C  ++C PPP I  
Sbjct: 96  --RYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGK---WSPELPVCAPIIC-PPPSIP- 148

Query: 171 GKHTFSEVEVFE--------YLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222
              TF+ + V++        Y D   + C P       ++ G  TI C  +  W++  PE
Sbjct: 149 ---TFATLRVYKPSAGNNSLYRDTAVFECLPQ-----HAMFGNDTITCTTHGNWTKL-PE 199

Query: 223 CKVVKCRFPV-VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
           C+ VKC FP   +NG          YYK    F C  G+ LDG + I C     W   +P
Sbjct: 200 CREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMP 258

Query: 282 KC 283
            C
Sbjct: 259 SC 260



 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 54/211 (25%), Positives = 87/211 (41%), Gaps = 18/211 (8%)

Query: 98  TCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILY-CELKGSVAIWSGKPPI 156
           TCP   D      VP    YE G ++ + C  GY   G    + C L G   +W      
Sbjct: 22  TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTG---LWPINTLK 78

Query: 157 CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVW 216
           C   +C     ++NG   ++    FEY + +++SC+       F L G  +  C +   W
Sbjct: 79  CTPRVCPFAGILENGAVRYT---TFEYPNTISFSCNTG-----FYLNGADSAKCTEEGKW 130

Query: 217 SRAAPECKVVKCRFPVVENGKQISGF----GKKFYYKATVMFECDKGFYLDGSDTIVCDS 272
           S   P C  + C  P +     +  +    G    Y+ T +FEC     + G+DTI C +
Sbjct: 131 SPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTT 190

Query: 273 NSTWDPPVPKCLKVSTSSTTKSPASSASGYP 303
           +  W   +P+C +V     ++ P +    YP
Sbjct: 191 HGNW-TKLPECREVKCPFPSR-PDNGFVNYP 219


>gi|168693643 decay accelerating factor for complement isoform 2
           precursor [Homo sapiens]
          Length = 440

 Score =  107 bits (266), Expect = 2e-23
 Identities = 64/196 (32%), Positives = 96/196 (48%), Gaps = 13/196 (6%)

Query: 34  ACEEPPTFEAMELIGK--PKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91
           +CE P    +  L      + Y+ +G  V+Y+C+ GY   P L+    C +N  W   + 
Sbjct: 97  SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKW-STAV 155

Query: 92  DACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWS 151
           + C +++CP   +  NGQ +   G   FG  + F CN GY L G    +C + GS   WS
Sbjct: 156 EFCKKKSCPNPGEIRNGQ-IDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWS 214

Query: 152 GKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC- 210
              P C ++ C  PP+I NG     E + + Y  +VTY+C+       F++IGE +IYC 
Sbjct: 215 DPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG-----FTMIGEHSIYCT 268

Query: 211 --GDNSVWSRAAPECK 224
              D   WS   PEC+
Sbjct: 269 VNNDEGEWSGPPPECR 284



 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 69/283 (24%), Positives = 117/283 (41%), Gaps = 20/283 (7%)

Query: 17  PGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLAT 76
           P LLL  ++ L   + D C  PP     +   + +  +     + YKC++ +  IP    
Sbjct: 19  PRLLLLVLLCLPAVWGD-CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKD 77

Query: 77  HTICDRNHTWLPVSDDACYR--ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLI 134
             IC +   W  + ++ C R  E    +      Q       +  G  + + C  GY   
Sbjct: 78  SVICLKGSQWSDI-EEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRR- 135

Query: 135 GEEILYCELKGSVAI-WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP 193
            E  L  +L     + WS     C+K  C  P +I+NG+       +F     +++SC+ 
Sbjct: 136 -EPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGA--TISFSCNT 192

Query: 194 APGPDPFSLIGESTIYC---GDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKA 250
                 + L G ++ +C   G +  WS   PEC+ + C  P   +   I G    + Y+ 
Sbjct: 193 G-----YKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQ 247

Query: 251 TVMFECDKGFYLDGSDTIVCDSNS---TWDPPVPKCLKVSTSS 290
           +V + C+KGF + G  +I C  N+    W  P P+C   S +S
Sbjct: 248 SVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTS 290


>gi|10835143 decay accelerating factor for complement isoform 1
           preproprotein [Homo sapiens]
          Length = 381

 Score =  107 bits (266), Expect = 2e-23
 Identities = 64/196 (32%), Positives = 96/196 (48%), Gaps = 13/196 (6%)

Query: 34  ACEEPPTFEAMELIGK--PKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91
           +CE P    +  L      + Y+ +G  V+Y+C+ GY   P L+    C +N  W   + 
Sbjct: 97  SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKW-STAV 155

Query: 92  DACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWS 151
           + C +++CP   +  NGQ +   G   FG  + F CN GY L G    +C + GS   WS
Sbjct: 156 EFCKKKSCPNPGEIRNGQ-IDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWS 214

Query: 152 GKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC- 210
              P C ++ C  PP+I NG     E + + Y  +VTY+C+       F++IGE +IYC 
Sbjct: 215 DPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG-----FTMIGEHSIYCT 268

Query: 211 --GDNSVWSRAAPECK 224
              D   WS   PEC+
Sbjct: 269 VNNDEGEWSGPPPECR 284



 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 69/283 (24%), Positives = 117/283 (41%), Gaps = 20/283 (7%)

Query: 17  PGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLAT 76
           P LLL  ++ L   + D C  PP     +   + +  +     + YKC++ +  IP    
Sbjct: 19  PRLLLLVLLCLPAVWGD-CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKD 77

Query: 77  HTICDRNHTWLPVSDDACYR--ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLI 134
             IC +   W  + ++ C R  E    +      Q       +  G  + + C  GY   
Sbjct: 78  SVICLKGSQWSDI-EEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRR- 135

Query: 135 GEEILYCELKGSVAI-WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP 193
            E  L  +L     + WS     C+K  C  P +I+NG+       +F     +++SC+ 
Sbjct: 136 -EPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGA--TISFSCNT 192

Query: 194 APGPDPFSLIGESTIYC---GDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKA 250
                 + L G ++ +C   G +  WS   PEC+ + C  P   +   I G    + Y+ 
Sbjct: 193 G-----YKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQ 247

Query: 251 TVMFECDKGFYLDGSDTIVCDSNS---TWDPPVPKCLKVSTSS 290
           +V + C+KGF + G  +I C  N+    W  P P+C   S +S
Sbjct: 248 SVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTS 290


>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
          Length = 3565

 Score =  104 bits (260), Expect = 1e-22
 Identities = 68/236 (28%), Positives = 102/236 (43%), Gaps = 23/236 (9%)

Query: 57   GERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGT 116
            G    + C  GY  +        C  N  W   S+  C    C    DP+    +  +G 
Sbjct: 2642 GATAIFTCNTGYTLVGSHVRE--CLANGLWSG-SETRCLAGHCGS-PDPIVNGHISGDG- 2696

Query: 117  YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFS 176
            + +   + + CN G+ L+G  +  C        WSG+ P+C  + C  P    N  H F+
Sbjct: 2697 FSYRDTVVYQCNPGFRLVGTSVRICLQDHK---WSGQTPVCVPITCGHPG---NPAHGFT 2750

Query: 177  EVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFP----- 231
                F   D V ++C+       + L G S   C  N  WS   P C+VV C  P     
Sbjct: 2751 NGSEFNLNDVVNFTCNTG-----YLLQGVSRAQCRSNGQWSSPLPTCRVVNCSDPGFVEN 2805

Query: 232  VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVS 287
             + +G+Q   F + F Y  ++++ C KGFYL GS  + C +N  WD  +PKCL +S
Sbjct: 2806 AIRHGQQ--NFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKCLAIS 2859



 Score =  100 bits (250), Expect = 2e-21
 Identities = 74/239 (30%), Positives = 96/239 (40%), Gaps = 24/239 (10%)

Query: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDD--ACYRETCPYIRDPLNGQAVP 112
            E G +V   C  GY+          C  N TW  + D+  +C   +C  +  P NG  + 
Sbjct: 2580 EYGAQVLLSCSPGYYLEGWRLLR--CQANGTW-NIGDERPSCRVISCGSLSFPPNGNKIG 2636

Query: 113  ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGK 172
                Y  G    F CN GY L+G  +  C   G   +WSG    C    C  P  I NG 
Sbjct: 2637 TLTVY--GATAIFTCNTGYTLVGSHVRECLANG---LWSGSETRCLAGHCGSPDPIVNGH 2691

Query: 173  HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPV 232
             +    + F Y D V Y C+P      F L+G S   C  +  WS   P C  + C  P 
Sbjct: 2692 ISG---DGFSYRDTVVYQCNPG-----FRLVGTSVRICLQDHKWSGQTPVCVPITCGHP- 2742

Query: 233  VENGKQISGF--GKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTS 289
               G    GF  G +F     V F C+ G+ L G     C SN  W  P+P C  V+ S
Sbjct: 2743 ---GNPAHGFTNGSEFNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPTCRVVNCS 2798



 Score = 99.0 bits (245), Expect = 6e-21
 Identities = 69/231 (29%), Positives = 103/231 (44%), Gaps = 23/231 (9%)

Query: 58   ERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGT- 116
            + V Y+C  G+  +    +  IC ++H W   +   C   TC +  +P +G     NG+ 
Sbjct: 2701 DTVVYQCNPGFRLVG--TSVRICLQDHKWSGQTP-VCVPITCGHPGNPAHGFT---NGSE 2754

Query: 117  YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKN----GK 172
            +     ++F CN GY L G     C   G    WS   P C  V C+ P  ++N    G+
Sbjct: 2755 FNLNDVVNFTCNTGYLLQGVSRAQCRSNGQ---WSSPLPTCRVVNCSDPGFVENAIRHGQ 2811

Query: 173  HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPV 232
              F E   FEY  ++ Y C        F L+G S + C  N +W R+ P+C  + C  P 
Sbjct: 2812 QNFPES--FEYGMSILYHCKKG-----FYLLGSSALTCMANGLWDRSLPKCLAISCGHPG 2864

Query: 233  VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
            V     ++  G+ F Y A V + C     L G+DT VC  +S W   +P C
Sbjct: 2865 VPANAVLT--GELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHC 2913



 Score = 96.7 bits (239), Expect = 3e-20
 Identities = 70/251 (27%), Positives = 105/251 (41%), Gaps = 21/251 (8%)

Query: 60   VDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEF 119
            V Y C +GY     +  H  C  N TW   + D C   +C       NG  +     + F
Sbjct: 3002 VIYACWEGYKTSGLMTRH--CTANGTWTGTAPD-CTIISCGDPGTLANG--IQFGTDFTF 3056

Query: 120  GYQMHFICNEGYYL--IGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSE 177
               + + CN GY +  +    + C   G    W+   P+C+ VLC  PP ++NG    S+
Sbjct: 3057 NKTVSYQCNPGYVMEAVTSATIRCTKDGR---WNPSKPVCKAVLCPQPPPVQNGTVEGSD 3113

Query: 178  VEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGK 237
               F +  +++YSC      D + L   + + C    VW    P+C  V C  P +    
Sbjct: 3114 ---FRWGSSISYSC-----MDGYQLSHSAILSCEGRGVWKGEIPQCLPVFCGDPGIPAEG 3165

Query: 238  QISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPAS 297
            ++SG  K F YK+ V F+C   F L GS   VC ++ TW    P C+     +T   P +
Sbjct: 3166 RLSG--KSFTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPTCID-PAHNTCPDPGT 3222

Query: 298  SASGYPKPEEG 308
               G      G
Sbjct: 3223 PHFGIQNSSRG 3233



 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 66/235 (28%), Positives = 96/235 (40%), Gaps = 20/235 (8%)

Query: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
            +   + V Y+C  GY      +    C ++  W P S   C    CP      NG    +
Sbjct: 3054 FTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNP-SKPVCKAVLCPQPPPVQNGTVEGS 3112

Query: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
            +  + +G  + + C +GY L    IL CE +G   +W G+ P C  V C  P     G+ 
Sbjct: 3113 D--FRWGSSISYSCMDGYQLSHSAILSCEGRG---VWKGEIPQCLPVFCGDPGIPAEGRL 3167

Query: 174  TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPEC---KVVKCRF 230
            +      F Y   V + C       PF L+G S   C  +  WS   P C       C  
Sbjct: 3168 SGKS---FTYKSEVFFQCK-----SPFILVGSSRRVCQADGTWSGIQPTCIDPAHNTCPD 3219

Query: 231  PVVEN-GKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCL 284
            P   + G Q S  G  +   +TV F C KG+++ GS T  C +N TW     +C+
Sbjct: 3220 PGTPHFGIQNSSRG--YEVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTECI 3272



 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 73/270 (27%), Positives = 106/270 (39%), Gaps = 30/270 (11%)

Query: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTW---LPVSDDACYRETCP---YIRDPLN 107
            + + + V++ C  GY       +   C  N  W   LP     C    C    ++ + + 
Sbjct: 2755 FNLNDVVNFTCNTGYLLQG--VSRAQCRSNGQWSSPLPT----CRVVNCSDPGFVENAIR 2808

Query: 108  GQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPK 167
                    ++E+G  + + C +G+YL+G   L C   G   +W    P C  + C  P  
Sbjct: 2809 HGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANG---LWDRSLPKCLAISCGHPGV 2865

Query: 168  IKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVK 227
              N   T    E+F Y   V YSC  +      SLIG  T  C ++S WS A P C    
Sbjct: 2866 PANAVLTG---ELFTYGAVVHYSCRGSE-----SLIGNDTRVCQEDSHWSGALPHCTGNN 2917

Query: 228  CRFPVVENGKQISG--FGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
              F   + G    G   G  F  K+ + F C+ G  L GS    C  N +W    P C  
Sbjct: 2918 PGF-CGDPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEA 2976

Query: 286  VSTSSTTKSPASSASGYPKPEEGILDSLDV 315
            VS      +P +  +G     +GIL S  V
Sbjct: 2977 VSCG----NPGTPTNGMIVSSDGILFSSSV 3002



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 68/245 (27%), Positives = 103/245 (42%), Gaps = 35/245 (14%)

Query: 56   IGERVDYKCKKGYFYIPPLATHTICDRN----HTWLPVSDDACYRETCPYIRDPLNGQAV 111
            +G +V Y CK GY  +    ++  C RN    + W  ++   C   +C     P NG   
Sbjct: 2452 VGSKVHYFCKPGYRMVG--HSNATCRRNPLGMYQWDSLT-PLCQAVSCGIPESPGNGSF- 2507

Query: 112  PANGTYEFGYQMHFICNEGYYLIGEE--ILYCELKGSVAIWS--GKPPICEKVLCTPPPK 167
                 +    ++ + C+EG+ L   +     C+  G   +WS  GKPP C+ V C P  +
Sbjct: 2508 -TGNEFTLDSKVVYECHEGFKLESSQQATAVCQEDG---LWSNKGKPPTCKPVAC-PSIE 2562

Query: 168  IKNGKHTFSEV---EVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWS--RAAPE 222
             +  +H    +    + EY   V  SC P      + L G   + C  N  W+     P 
Sbjct: 2563 AQLSEHVIWRLVSGSLNEYGAQVLLSCSPG-----YYLEGWRLLRCQANGTWNIGDERPS 2617

Query: 223  CKVVKC---RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPP 279
            C+V+ C    FP   NG +I   G    Y AT +F C+ G+ L GS    C +N  W   
Sbjct: 2618 CRVISCGSLSFP--PNGNKI---GTLTVYGATAIFTCNTGYTLVGSHVRECLANGLWSGS 2672

Query: 280  VPKCL 284
              +CL
Sbjct: 2673 ETRCL 2677



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 66/252 (26%), Positives = 98/252 (38%), Gaps = 26/252 (10%)

Query: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
            +E G  + Y CKKG++ +   A    C  N  W   S   C   +C +   P N  AV  
Sbjct: 2818 FEYGMSILYHCKKGFYLLGSSAL--TCMANGLW-DRSLPKCLAISCGHPGVPAN--AVLT 2872

Query: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPIC---EKVLCTPPPKIKN 170
               + +G  +H+ C     LIG +   C+       WSG  P C       C  P    +
Sbjct: 2873 GELFTYGAVVHYSCRGSESLIGNDTRVCQEDSH---WSGALPHCTGNNPGFCGDPGTPAH 2929

Query: 171  GKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF 230
            G     +   F+    + +SC+         L G     C  N  WS   P C+ V C  
Sbjct: 2930 GSRLGDD---FKTKSLLRFSCEMG-----HQLRGSPERTCLLNGSWSGLQPVCEAVSCGN 2981

Query: 231  P-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTS 289
            P    NG  +S  G    + ++V++ C +G+   G  T  C +N TW    P C  +S  
Sbjct: 2982 PGTPTNGMIVSSDG--ILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCTIISCG 3039

Query: 290  STTKSPASSASG 301
                 P + A+G
Sbjct: 3040 ----DPGTLANG 3047



 Score = 72.8 bits (177), Expect = 5e-13
 Identities = 60/222 (27%), Positives = 88/222 (39%), Gaps = 28/222 (12%)

Query: 96   RETCPY--IRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKG-SVAIWSG 152
            R   PY  +  PL    +        G ++H+ C  GY ++G     C      +  W  
Sbjct: 2427 RYAAPYCSLTHPLKNGGILNRTAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDS 2486

Query: 153  KPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIG--ESTIYC 210
              P+C+ V C  P    NG  T +E   F     V Y C      + F L    ++T  C
Sbjct: 2487 LTPLCQAVSCGIPESPGNGSFTGNE---FTLDSKVVYECH-----EGFKLESSQQATAVC 2538

Query: 211  GDNSVWSRAA--PECKVVKCRFPVVENGKQISGF-------GKKFYYKATVMFECDKGFY 261
             ++ +WS     P CK V C  P +E   Q+S         G    Y A V+  C  G+Y
Sbjct: 2539 QEDGLWSNKGKPPTCKPVAC--PSIE--AQLSEHVIWRLVSGSLNEYGAQVLLSCSPGYY 2594

Query: 262  LDGSDTIVCDSNSTWD--PPVPKCLKVSTSSTTKSPASSASG 301
            L+G   + C +N TW+     P C  +S  S +  P  +  G
Sbjct: 2595 LEGWRLLRCQANGTWNIGDERPSCRVISCGSLSFPPNGNKIG 2636



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 34/106 (32%), Positives = 51/106 (48%), Gaps = 8/106 (7%)

Query: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
            YE+G  V ++C+KGY +I    T T C  N TW  +  + C    C     P +   V A
Sbjct: 3234 YEVGSTVFFRCRKGY-HIQGSTTRT-CLANLTWSGIQTE-CIPHACRQPETPAHAD-VRA 3289

Query: 114  NGTYEFGYQMHFICNEGYYLI-GEEILYCELKGSVAIWSGKPPICE 158
                 FGY + + C+ G++L  G E   C+       W+GK P+C+
Sbjct: 3290 IDLPTFGYTLVYTCHPGFFLAGGSEHRTCKADMK---WTGKSPVCK 3332



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 56/243 (23%), Positives = 84/243 (34%), Gaps = 54/243 (22%)

Query: 93  ACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCE-LKGSVAIWS 151
           A   + CP    P NG+   ++ +   G  + F C + Y L G + + C+ +  ++A WS
Sbjct: 343 ALVSDMCPDPGIPENGRRAGSDFS-RVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWS 401

Query: 152 GKPPICEKVLC--------------------------------TPPPKIKNGKHTFSEVE 179
              PIC    C                                T P K+   K  F E E
Sbjct: 402 DHRPICRARTCGSNLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDKVI--KLAFEEFE 459

Query: 180 VFEYLDAVTYSCDPAPGPDP---FSLIGEST---IYCGDNSVWSRAAPECKV----VKCR 229
           +    D +T       G      + L G S    I    N +W     +  +     K  
Sbjct: 460 LERGYDTLTVGDAGKVGDTRSVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAV 519

Query: 230 FPVVENG----KQISGFGKK----FYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
           +  +E G      I  +GK+    F +  T+ FEC   F L G   I C  N+ W    P
Sbjct: 520 YQEIEKGGCGDPGIPAYGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKP 579

Query: 282 KCL 284
            C+
Sbjct: 580 SCV 582



 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 32/104 (30%), Positives = 48/104 (46%), Gaps = 19/104 (18%)

Query: 225  VVKCRFPVVEN-GKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNS--TWDPPVP 281
            +VKC  P + N G +I   G   +    V++ C+ G+ + GS+T+ C S     WD P+P
Sbjct: 1215 LVKCEDPGIPNYGYRIRDEGH--FTDTVVLYSCNPGYAMHGSNTLTCLSGDRRVWDKPLP 1272

Query: 282  KC-------LKVSTSSTTKSPASSASGYPKPEEGILDSLDVWVI 318
             C       +  +TS    SP     GYP P +  L     W+I
Sbjct: 1273 SCIAECGGQIHAATSGRILSP-----GYPAPYDNNLHC--TWII 1309



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 31/109 (28%), Positives = 51/109 (46%), Gaps = 11/109 (10%)

Query: 218  RAAPECKVVKCR-FPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDS---- 272
            +A P     +C   P    G++I   G +F   + V FEC+ G+ L GS  + C S    
Sbjct: 1732 QAVPRTSDTQCSSVPEPRYGRRI---GSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNA 1788

Query: 273  NSTWDPPVPKCLKVSTSSTTKSPASSAS-GYPKPEEGILDSLDVWVIAV 320
             + W+  +P C+   + + T+   +  S GYP+P    L+   +W I V
Sbjct: 1789 LAQWNDTIPSCVVPCSGNFTQRRGTILSPGYPEPYGNNLNC--IWKIIV 1835



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 52/233 (22%), Positives = 85/233 (36%), Gaps = 70/233 (30%)

Query: 111 VPANG-----TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPIC-------- 157
           +PA G     ++  G  + F C   + L+GE ++ C+       WSG  P C        
Sbjct: 533 IPAYGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQ---WSGNKPSCVFSCFFNF 589

Query: 158 ---EKVLCTP--PPKIKNGKHT---------------FSEVEVFEYLDAVTYSCDPAPGP 197
                ++ +P  P +  N  +                F++ +V    D +    D   G 
Sbjct: 590 TASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQFDFLAVKDD---GI 646

Query: 198 DPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVEN---------------------G 236
              +++G  +     N V S+ A    +V+  F    +                     G
Sbjct: 647 SDITVLGTFS----GNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQNECHDPG 702

Query: 237 KQISG--FGKKFYYKATVMFECDKGFY-LDGSDTIVC---DSNSTWDPPVPKC 283
             I+G  FG +F   ++V F CD GF    GS++I C   D N  W   VP+C
Sbjct: 703 IPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRC 755



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 55/232 (23%), Positives = 83/232 (35%), Gaps = 61/232 (26%)

Query: 105 PLNGQAVPANGTYEFGYQMHFICNEGYYLI-GEEILYCELKGSVAIWSGKPPICEK---- 159
           P+NG+       +  G  + F C++G+    G E + C L+    +WS   P CE     
Sbjct: 704 PINGRRF--GDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEAPCGG 761

Query: 160 -------VLCTP--PPKIKNGKH---------------TFSEVEVFEYLDAVTYSCDPAP 195
                  V+  P  P   K+  H               TF   +     D +     PA 
Sbjct: 762 HLTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRFQTEVNYDTLEVRDGPAS 821

Query: 196 GPDPFSLIGE-----------ST------IYCGDNSVWS------RAAPECKVVKCRFP- 231
                 LIGE           ST      ++  DNS  S        +   +   C  P 
Sbjct: 822 SS---PLIGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSIGFLIHYESVTLESDSCLDPG 878

Query: 232 VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
           +  NG +  G    F  ++TV F CD G+ L   + +VC+ N  W+  +P C
Sbjct: 879 IPVNGHRHGG---DFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSC 927



 Score = 38.5 bits (88), Expect = 0.009
 Identities = 53/233 (22%), Positives = 87/233 (37%), Gaps = 59/233 (25%)

Query: 107  NGQAVPANGTY-----EFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPIC---- 157
            N   +P NGT      E G  + F C+ GY L G+  + C    +   W   PP C    
Sbjct: 1393 NDPGMPQNGTRYGDSREAGDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIAAC 1452

Query: 158  -------EKVLCTP--PPKIKNGKHTFSEVEVF-EYLDAV---TYSCDPA-------PGP 197
                     V+ +P  P     GK     V+V  +++ A+   +++ +P+        G 
Sbjct: 1453 GGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPSYDFLHIYEGE 1512

Query: 198  DPFS-LIGE-------STIYCGDNSVWSRAAPECKVVKCRFPV---------------VE 234
            D  S LIG          I    NS++     +  V    F +               + 
Sbjct: 1513 DSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEKPREACFDPGNIM 1572

Query: 235  NGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVC----DSNSTWDPPVPKC 283
            NG ++   G  F   +T+ ++CD G+ +    +I C    D   +WD  +P C
Sbjct: 1573 NGTRV---GTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSC 1622



 Score = 38.1 bits (87), Expect = 0.012
 Identities = 27/73 (36%), Positives = 32/73 (43%), Gaps = 9/73 (12%)

Query: 158 EKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWS 217
           EK  C  P     GK T S    F + D +T+ C     P  F L+GE  I C  N+ WS
Sbjct: 524 EKGGCGDPGIPAYGKRTGSS---FLHGDTLTFEC-----PAAFELVGERVITCQQNNQWS 575

Query: 218 RAAPECKVVKCRF 230
              P C V  C F
Sbjct: 576 GNKPSC-VFSCFF 587



 Score = 35.8 bits (81), Expect = 0.062
 Identities = 20/60 (33%), Positives = 28/60 (46%), Gaps = 6/60 (10%)

Query: 251  TVMFECDKGFYLDGSDTIVC---DSNSTWDPPVPKCLKVSTSSTTKSPAS--SASGYPKP 305
            TV F+CD G+ L G   I C   ++   W P  P C+     + T  PA    +  YP+P
Sbjct: 1413 TVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIAACGGNLT-GPAGVILSPNYPQP 1471



 Score = 34.3 bits (77), Expect = 0.18
 Identities = 30/112 (26%), Positives = 48/112 (42%), Gaps = 9/112 (8%)

Query: 213 NSVWSRAAPECKVVKCRFP-VVENGKQI-SGFGKKFYYKATVMFECDKGFYLDGSDTIVC 270
           NSV S+         C  P + ENG++  S F +     A V F C+  + L GS +I C
Sbjct: 334 NSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSR---VGANVQFSCEDNYVLQGSKSITC 390

Query: 271 ----DSNSTWDPPVPKCLKVSTSSTTKSPASSASGYPKPEEGILDSLDVWVI 318
               ++ + W    P C   +  S  + P+   +    P +   ++  VWVI
Sbjct: 391 QRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQYEDNAHCVWVI 442



 Score = 34.3 bits (77), Expect = 0.18
 Identities = 24/93 (25%), Positives = 41/93 (44%), Gaps = 8/93 (8%)

Query: 231  PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDS--NSTWDPPVPKC-LKVS 287
            P  +NG  I+     +    +V FEC  G+ L G   + C    N  W+ P P+C     
Sbjct: 2092 PPFQNGYMINS---DYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCDAPCG 2148

Query: 288  TSSTTKSPASSASGYPKPEEGILDSLDVWVIAV 320
             + T+++    + G+P     + D   +W+I V
Sbjct: 2149 YNVTSQNGTIYSPGFPDEYPILKDC--IWLITV 2179



 Score = 33.1 bits (74), Expect = 0.40
 Identities = 15/42 (35%), Positives = 24/42 (57%), Gaps = 1/42 (2%)

Query: 117  YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE 158
            +E G  + + C+ GY L+G +IL C+L   +  + G  P CE
Sbjct: 2277 FEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQ-FEGSLPTCE 2317



 Score = 32.7 bits (73), Expect = 0.52
 Identities = 17/60 (28%), Positives = 30/60 (50%), Gaps = 3/60 (5%)

Query: 99   CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCE-LKGSVAIWSGKPPIC 157
            C  + +P  G+ + +   +  G  + F CN GY L G   L+C+ +  ++A W+   P C
Sbjct: 1742 CSSVPEPRYGRRIGSE--FSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSC 1799



 Score = 32.3 bits (72), Expect = 0.68
 Identities = 20/62 (32%), Positives = 27/62 (43%), Gaps = 3/62 (4%)

Query: 97   ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
            + CP      NG  +  N  Y  G  + F C  GY LIG  +L C+  G    W+   P 
Sbjct: 2086 QNCPDPPPFQNGYMI--NSDYSVGQSVSFECYPGYILIGHPVLTCQ-HGINRNWNYPFPR 2142

Query: 157  CE 158
            C+
Sbjct: 2143 CD 2144



 Score = 32.0 bits (71), Expect = 0.89
 Identities = 27/115 (23%), Positives = 48/115 (41%), Gaps = 18/115 (15%)

Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
           F     VT+SCDP      ++L  +  + C  N  W+ A P C  +   +   ++G  +S
Sbjct: 890 FGIRSTVTFSCDPG-----YTLSDDEPLVCERNHQWNHALPSCDALCGGYIQGKSGTVLS 944

Query: 241 GFGKKFYYKA-----TVMFECDKG-------FYLDGS-DTIVCDSNSTWDPPVPK 282
                FY  +     T+     KG       F+L+ S D ++   + ++  PV +
Sbjct: 945 PGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESSHDYLLITEDGSFSEPVAR 999



 Score = 31.2 bits (69), Expect = 1.5
 Identities = 15/44 (34%), Positives = 24/44 (54%), Gaps = 8/44 (18%)

Query: 187  VTYSCDPAPGPDPFSLIGESTIYC--GDNSVWSRAAPECKVVKC 228
            V YSC+P      +++ G +T+ C  GD  VW +  P C + +C
Sbjct: 1241 VLYSCNPG-----YAMHGSNTLTCLSGDRRVWDKPLPSC-IAEC 1278



 Score = 30.8 bits (68), Expect = 2.0
 Identities = 20/81 (24%), Positives = 35/81 (43%), Gaps = 5/81 (6%)

Query: 243 GKKFYYKATVMFECDKGFYLDGSDTIVC----DSNSTWDPPVPKC-LKVSTSSTTKSPAS 297
           G +F     + + C  G+ L+G   + C     + ++WD P P C  + +   T +  +S
Sbjct: 158 GTRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFCRAEGACGGTLRGTSS 217

Query: 298 SASGYPKPEEGILDSLDVWVI 318
           S S    P E   ++   W I
Sbjct: 218 SISSPHFPSEYENNADCTWTI 238



 Score = 29.6 bits (65), Expect = 4.4
 Identities = 19/63 (30%), Positives = 28/63 (44%), Gaps = 6/63 (9%)

Query: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYI--PPLATHTICDRNHTW-LPVSD 91
            C +PP F+   +I      Y +G+ V ++C  GY  I  P L      +RN  +  P  D
Sbjct: 2088 CPDPPPFQNGYMINSD---YSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCD 2144

Query: 92   DAC 94
              C
Sbjct: 2145 APC 2147



 Score = 28.9 bits (63), Expect = 7.5
 Identities = 15/49 (30%), Positives = 23/49 (46%), Gaps = 6/49 (12%)

Query: 162  CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC 210
            C PPP +   +   +E + FE  D V Y C P      ++L+G   + C
Sbjct: 2259 CQPPPAVPQAE-MLTEDDDFEIGDFVKYQCHPG-----YTLVGTDILTC 2301


>gi|62739188 complement factor H isoform b precursor [Homo sapiens]
          Length = 449

 Score =  101 bits (251), Expect = 1e-21
 Identities = 81/278 (29%), Positives = 123/278 (44%), Gaps = 31/278 (11%)

Query: 19  LLLAAMVLLLYSF---SDACEEPPTFEAMELIGK-PKPYYEIGERVDYKCKKGYFYIPPL 74
           LL   + L+L++     D  E PP      L G      Y  G +  YKC+ GY     L
Sbjct: 3   LLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGY---RSL 59

Query: 75  ATHTICDRNHTWLPVSD-DACYRETCPYIRD-PLNGQAVPANGTYEFGYQMHFICNEGYY 132
               +  R   W+ ++    C +  C +  D P     +     +E+G +  + CNEGY 
Sbjct: 60  GNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQ 119

Query: 133 LIGEEILY--CELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV---FEYLDAV 187
           L+GE I Y  C+  G    W+   PICE V C P    +NGK   S +E    + +  AV
Sbjct: 120 LLGE-INYRECDTDG----WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAV 174

Query: 188 TYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFY 247
            + C+       + + G+  ++C D+  WS+  P+C  + C+ P V NG  IS   +K  
Sbjct: 175 RFVCNSG-----YKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPIS---QKII 226

Query: 248 YKATVMFE--CDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
           YK    F+  C+ G+        VC + S W  P+P C
Sbjct: 227 YKENERFQYKCNMGYEYSERGDAVC-TESGW-RPLPSC 262



 Score = 86.7 bits (213), Expect = 3e-17
 Identities = 60/207 (28%), Positives = 94/207 (45%), Gaps = 20/207 (9%)

Query: 94  CYRETCPYIRDPLNGQAVP---ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150
           C  E C  +    N + +    ++ TY  G Q  + C  GY  +G  I+ C  KG    W
Sbjct: 16  CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGE---W 71

Query: 151 SGKPPI--CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
               P+  C+K  C  P     G  T +   VFEY     Y+C+     + + L+GE   
Sbjct: 72  VALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCN-----EGYQLLGEINY 126

Query: 209 YCGDNSVWSRAAPECKVVKCRFPVV--ENGKQISGF---GKKFYYKATVMFECDKGFYLD 263
              D   W+   P C+VVKC  PV   ENGK +S      +++++   V F C+ G+ ++
Sbjct: 127 RECDTDGWTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185

Query: 264 GSDTIVCDSNSTWDPPVPKCLKVSTSS 290
           G + + C  +  W    PKC+++S  S
Sbjct: 186 GDEEMHCSDDGFWSKEKPKCVEISCKS 212



 Score = 62.4 bits (150), Expect = 6e-10
 Identities = 71/267 (26%), Positives = 106/267 (39%), Gaps = 42/267 (15%)

Query: 34  ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
           +C+ P       +    K  Y+  ER  YKC  GY Y        +C  +  W P+   +
Sbjct: 209 SCKSPDVINGSPI--SQKIIYKENERFQYKCNMGYEYSE--RGDAVCTESG-WRPLP--S 261

Query: 94  CYRETC--PYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGE-EILYCELKGSVAIW 150
           C  ++C  PYI    NG   P    +  G ++ + C  G+Y         C   G +   
Sbjct: 262 CEEKSCDNPYIP---NGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPA- 317

Query: 151 SGKPPICEKVLCTPPPKIKNG-------KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
               P C    C  P  IK+G       +  +  V V +Y    +Y CD     + F   
Sbjct: 318 ----PRCTLKPCDYPD-IKHGGLYHENMRRPYFPVAVGKYY---SYYCD-----EHFETP 364

Query: 204 GEST---IYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGF 260
             S    I+C  +  WS A P  +  KC FP +ENG      G+KF    ++   C  G+
Sbjct: 365 SGSYWDHIHCTQDG-WSPAVPCLR--KCYFPYLENGYN-QNHGRKFVQGKSIDVACHPGY 420

Query: 261 YLDGSDTIVCDSNSTWDPPVPKCLKVS 287
            L  + T V    + W  P P+C++VS
Sbjct: 421 ALPKAQTTVTCMENGWS-PTPRCIRVS 446


>gi|62739186 complement factor H isoform a precursor [Homo sapiens]
          Length = 1231

 Score =  101 bits (251), Expect = 1e-21
 Identities = 81/278 (29%), Positives = 123/278 (44%), Gaps = 31/278 (11%)

Query: 19  LLLAAMVLLLYSF---SDACEEPPTFEAMELIGK-PKPYYEIGERVDYKCKKGYFYIPPL 74
           LL   + L+L++     D  E PP      L G      Y  G +  YKC+ GY     L
Sbjct: 3   LLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGY---RSL 59

Query: 75  ATHTICDRNHTWLPVSD-DACYRETCPYIRD-PLNGQAVPANGTYEFGYQMHFICNEGYY 132
               +  R   W+ ++    C +  C +  D P     +     +E+G +  + CNEGY 
Sbjct: 60  GNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQ 119

Query: 133 LIGEEILY--CELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV---FEYLDAV 187
           L+GE I Y  C+  G    W+   PICE V C P    +NGK   S +E    + +  AV
Sbjct: 120 LLGE-INYRECDTDG----WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAV 174

Query: 188 TYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFY 247
            + C+       + + G+  ++C D+  WS+  P+C  + C+ P V NG  IS   +K  
Sbjct: 175 RFVCNSG-----YKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPIS---QKII 226

Query: 248 YKATVMFE--CDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
           YK    F+  C+ G+        VC + S W  P+P C
Sbjct: 227 YKENERFQYKCNMGYEYSERGDAVC-TESGW-RPLPSC 262



 Score = 86.7 bits (213), Expect = 3e-17
 Identities = 60/207 (28%), Positives = 94/207 (45%), Gaps = 20/207 (9%)

Query: 94  CYRETCPYIRDPLNGQAVP---ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150
           C  E C  +    N + +    ++ TY  G Q  + C  GY  +G  I+ C  KG    W
Sbjct: 16  CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGE---W 71

Query: 151 SGKPPI--CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
               P+  C+K  C  P     G  T +   VFEY     Y+C+     + + L+GE   
Sbjct: 72  VALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCN-----EGYQLLGEINY 126

Query: 209 YCGDNSVWSRAAPECKVVKCRFPVV--ENGKQISGF---GKKFYYKATVMFECDKGFYLD 263
              D   W+   P C+VVKC  PV   ENGK +S      +++++   V F C+ G+ ++
Sbjct: 127 RECDTDGWTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185

Query: 264 GSDTIVCDSNSTWDPPVPKCLKVSTSS 290
           G + + C  +  W    PKC+++S  S
Sbjct: 186 GDEEMHCSDDGFWSKEKPKCVEISCKS 212



 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 64/250 (25%), Positives = 109/250 (43%), Gaps = 27/250 (10%)

Query: 53  YYEIGERVDYKCKKGYFYIPPLATHTICDRNHTW--LPVSDDACYRETCPYIRDPLNGQA 110
           ++++ + +DY+C  GY       T +I    + W  LP+    CY   C   +  ++   
Sbjct: 525 WFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPI----CYERECELPKIDVHLVP 580

Query: 111 VPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVL--CTPPPKI 168
                 Y+ G  + F C  G+ ++G   + C   G     S   PIC++ +  C PPP++
Sbjct: 581 DRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGL----SPDLPICKEQVQSCGPPPEL 636

Query: 169 KNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKC 228
            NG       E + + + V Y C+P      F + G + I C D   W+   P C V + 
Sbjct: 637 LNGNVKEKTKEEYGHSEVVEYYCNPR-----FLMKGPNKIQCVDGE-WT-TLPVCIVEES 689

Query: 229 R---FPVVENG-KQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCL 284
                P +E+G  Q+S     +YY  +V F C + F + G  +I C  +  W   +P+C+
Sbjct: 690 TCGDIPELEHGWAQLS--SPPYYYGDSVEFNCSESFTMIGHRSITC-IHGVW-TQLPQCV 745

Query: 285 KVSTSSTTKS 294
            +      KS
Sbjct: 746 AIDKLKKCKS 755



 Score = 72.0 bits (175), Expect = 8e-13
 Identities = 61/245 (24%), Positives = 104/245 (42%), Gaps = 22/245 (8%)

Query: 49  KPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLP-VSDDACYRETCPYIRDPLN 107
           K K  ++    + Y+C+    +I     HT+C  N  W P V+      + CP      N
Sbjct: 766 KNKKEFDHNSNIRYRCRGKEGWI-----HTVCI-NGRWDPEVNCSMAQIQLCPPPPQIPN 819

Query: 108 GQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPK 167
              +     Y  G ++  +C E Y +   E + C+       W   P   EK+ C+ PP+
Sbjct: 820 SHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCK----DGRWQSIPLCVEKIPCSQPPQ 875

Query: 168 IKNG--KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKV 225
           I++G    + S  E + +   ++Y+C+   G    S   E+T Y G    WS + P+C+ 
Sbjct: 876 IEHGTINSSRSSQESYAHGTKLSYTCE---GGFRISEENETTCYMGK---WS-SPPQCEG 928

Query: 226 VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
           + C+ P   +   ++     + Y   V ++C +GF +DG     C     W  P P C+K
Sbjct: 929 LPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKC-LGEKWSHP-PSCIK 986

Query: 286 VSTSS 290
               S
Sbjct: 987 TDCLS 991



 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 65/268 (24%), Positives = 109/268 (40%), Gaps = 31/268 (11%)

Query: 35   CEEPPTFE--AMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPV--- 89
            C +PP  E   +      +  Y  G ++ Y C+ G+          I + N T   +   
Sbjct: 870  CSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGF---------RISEENETTCYMGKW 920

Query: 90   -SDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVA 148
             S   C    C    +  +G     + +Y++G ++ + C EG+ + G  I  C  +    
Sbjct: 921  SSPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEK--- 977

Query: 149  IWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
             WS  PP C K  C   P  +N      + +V++  + VTY+C        + + G S +
Sbjct: 978  -WS-HPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTC-----ATYYKMDGASNV 1030

Query: 209  YCGDNSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDT 267
             C  NS W+   P C+   C   P V+N   +S    K+     V ++C   + + G + 
Sbjct: 1031 TC-INSRWT-GRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEE 1088

Query: 268  IVCDSNSTWDPPVPKCLKVSTSSTTKSP 295
            ++C  N  W  P P+C K ST      P
Sbjct: 1089 VMC-LNGNWTEP-PQC-KDSTGKCGPPP 1113



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 75/282 (26%), Positives = 112/282 (39%), Gaps = 44/282 (15%)

Query: 34  ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
           +C+ P       +    K  Y+  ER  YKC  GY Y        +C  +  W P+   +
Sbjct: 209 SCKSPDVINGSPI--SQKIIYKENERFQYKCNMGYEYSE--RGDAVCTESG-WRPLP--S 261

Query: 94  CYRETC--PYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGE-EILYCELKGSVAIW 150
           C  ++C  PYI    NG   P    +  G ++ + C  G+Y         C   G +   
Sbjct: 262 CEEKSCDNPYIP---NGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPA- 317

Query: 151 SGKPPICEKVLCTPPPKIKNG-------KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
               P C    C  P  IK+G       +  +  V V +Y    +Y CD     + F   
Sbjct: 318 ----PRCTLKPCDYPD-IKHGGLYHENMRRPYFPVAVGKYY---SYYCD-----EHFETP 364

Query: 204 GEST---IYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGF 260
             S    I+C  +  WS A P  +  KC FP +ENG      G+KF    ++   C  G+
Sbjct: 365 SGSYWDHIHCTQDG-WSPAVPCLR--KCYFPYLENGYN-QNHGRKFVQGKSIDVACHPGY 420

Query: 261 YLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGY 302
            L  + T V    + W  P P+C++V T S  KS     +G+
Sbjct: 421 ALPKAQTTVTCMENGWS-PTPRCIRVKTCS--KSSIDIENGF 459



 Score = 62.4 bits (150), Expect = 6e-10
 Identities = 71/267 (26%), Positives = 107/267 (40%), Gaps = 41/267 (15%)

Query: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
            C   P+FE    +G+ K  Y+ GE+V Y C    +Y    A++  C  N  W       C
Sbjct: 989  CLSLPSFENAIPMGEKKDVYKAGEQVTYTC--ATYYKMDGASNVTC-INSRW--TGRPTC 1043

Query: 95   YRETCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
               +C       N   V      Y  G ++ + C   Y + G+E + C L G+   W+ +
Sbjct: 1044 RDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMC-LNGN---WT-E 1098

Query: 154  PPICEKVL--CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG 211
            PP C+     C PPP I NG  T   + V+    +V Y C      + + L G   I C 
Sbjct: 1099 PPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ-----NLYQLEGNKRITC- 1152

Query: 212  DNSVWSRAAPECKVVKCRFPVVENGKQISGFG--------KKFYYKA--TVMFECDKGFY 261
             N  WS         KC  P V + + +  +         +K Y +   +V F C +G+ 
Sbjct: 1153 RNGQWSEPP------KCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYR 1206

Query: 262  LDG-SDTIVCDSNSTWDPPV--PKCLK 285
            L   S T+     + WD  +  P C K
Sbjct: 1207 LSSRSHTL---RTTCWDGKLEYPTCAK 1230



 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 60/251 (23%), Positives = 113/251 (45%), Gaps = 26/251 (10%)

Query: 37  EPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYR 96
           E P  +   +  + K  Y++GE + + CK G+  + P +           LP+  +    
Sbjct: 570 ELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICKEQV-- 627

Query: 97  ETCPYIRDPLNGQAVPANGTYEFGYQ--MHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
           ++C    + LNG  V      E+G+   + + CN  + + G   + C + G    W+  P
Sbjct: 628 QSCGPPPELLNGN-VKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQC-VDGE---WTTLP 682

Query: 155 P-ICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDN 213
             I E+  C   P++++G    S    + Y D+V ++C      + F++IG  +I C  +
Sbjct: 683 VCIVEESTCGDIPELEHGWAQLSSPPYY-YGDSVEFNCS-----ESFTMIGHRSITC-IH 735

Query: 214 SVWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIV 269
            VW++  P+C    K+ KC+   +   ++     K+F + + + + C +G   +G    V
Sbjct: 736 GVWTQ-LPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRC-RG--KEGWIHTV 791

Query: 270 CDSNSTWDPPV 280
           C  N  WDP V
Sbjct: 792 C-INGRWDPEV 801



 Score = 32.0 bits (71), Expect = 0.89
 Identities = 12/35 (34%), Positives = 19/35 (54%)

Query: 34   ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGY 68
            +C  PPT +   ++ +    Y  GERV Y+C+  Y
Sbjct: 1047 SCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPY 1081


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.140    0.455 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,319,735
Number of Sequences: 37866
Number of extensions: 985927
Number of successful extensions: 3874
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 79
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 2341
Number of HSP's gapped (non-prelim): 521
length of query: 363
length of database: 18,247,518
effective HSP length: 104
effective length of query: 259
effective length of database: 14,309,454
effective search space: 3706148586
effective search space used: 3706148586
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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