Search of human proteins with 27262659

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27262659 colony stimulating factor 1 receptor precursor
[Homo sapiens]
         (972 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27262659 colony stimulating factor 1 receptor precursor [Homo...  1991   0.0  
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge...   669   0.0  
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene...   666   0.0  
gi|5453870 platelet-derived growth factor receptor alpha precurs...   492   e-139
gi|4505683 platelet-derived growth factor receptor beta precurso...   491   e-138
gi|121114304 fms-related tyrosine kinase 3 [Homo sapiens]             444   e-124
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [...   361   2e-99
gi|11321597 kinase insert domain receptor precursor [Homo sapiens]    340   5e-93
gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor [...   337   2e-92
gi|103472027 fms-related tyrosine kinase 4 isoform 2 precursor [...   337   2e-92
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur...   281   2e-75
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur...   281   2e-75
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs...   280   6e-75
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu...   278   1e-74
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu...   276   7e-74
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu...   276   7e-74
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu...   275   1e-73
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu...   275   1e-73
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur...   274   3e-73
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur...   274   3e-73
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur...   274   3e-73
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur...   274   3e-73
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu...   274   3e-73
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu...   274   3e-73
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu...   273   6e-73
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu...   273   6e-73
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur...   273   7e-73
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu...   267   3e-71
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu...   267   3e-71
gi|10862701 ret proto-oncogene isoform c [Homo sapiens]               265   2e-70

>gi|27262659 colony stimulating factor 1 receptor precursor [Homo
           sapiens]
          Length = 972

 Score = 1991 bits (5158), Expect = 0.0
 Identities = 972/972 (100%), Positives = 972/972 (100%)

Query: 1   MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTL 60
           MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTL
Sbjct: 1   MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTL 60

Query: 61  YSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFED 120
           YSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFED
Sbjct: 61  YSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFED 120

Query: 121 QDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSAL 180
           QDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSAL
Sbjct: 121 QDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSAL 180

Query: 181 MGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHN 240
           MGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHN
Sbjct: 181 MGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHN 240

Query: 241 NTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAY 300
           NTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAY
Sbjct: 241 NTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAY 300

Query: 301 LNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTY 360
           LNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTY
Sbjct: 301 LNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTY 360

Query: 361 RHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCA 420
           RHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCA
Sbjct: 361 RHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCA 420

Query: 421 ASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHN 480
           ASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHN
Sbjct: 421 ASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHN 480

Query: 481 QTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKY 540
           QTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKY
Sbjct: 481 QTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKY 540

Query: 541 KQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEAT 600
           KQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEAT
Sbjct: 541 KQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEAT 600

Query: 601 AFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVL 660
           AFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVL
Sbjct: 601 AFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVL 660

Query: 661 VITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGV 720
           VITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGV
Sbjct: 661 VITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGV 720

Query: 721 DTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVA 780
           DTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVA
Sbjct: 721 DTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVA 780

Query: 781 ARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWS 840
           ARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWS
Sbjct: 781 ARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWS 840

Query: 841 YGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR 900
           YGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR
Sbjct: 841 YGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR 900

Query: 901 PTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIA 960
           PTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIA
Sbjct: 901 PTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIA 960

Query: 961 QPLLQPNNYQFC 972
           QPLLQPNNYQFC
Sbjct: 961 QPLLQPNNYQFC 972


>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
           homolog isoform 2 precursor [Homo sapiens]
          Length = 972

 Score =  669 bits (1726), Expect = 0.0
 Identities = 400/957 (41%), Positives = 552/957 (57%), Gaps = 62/957 (6%)

Query: 5   VLLLLLVATAWHGQGIPVIEPSVP-------ELVVKPGATVTLRCVGNGSVEWDGPPSPH 57
           +LLLL V T      +   EPS P       +L+V+ G  + L C   G V+W       
Sbjct: 14  LLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDE 73

Query: 58  WTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVV 117
               ++   +   T  A   NTG Y CT      G S +I+++V+DPA+ + ++ + +  
Sbjct: 74  T---NENKQNEWITEKAEATNTGKYTCTNKH---GLSNSIYVFVRDPAKLF-LVDRSLYG 126

Query: 118 FEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQ-DYQ 176
            ED D L+ C LTDP +    SL   +G+PL +   +   P  G  I   K    +    
Sbjct: 127 KEDNDTLVRCPLTDPEV-TNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLH 185

Query: 177 CSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVF 236
           CS    G+ V+S    LKV+      P +++  A  +   GE   + C+    DV+  V+
Sbjct: 186 CSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIK--DVSSSVY 243

Query: 237 L----QHNNTKLAIPQQSDFHNN-RYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSM 291
                +++ TKL     S  H +  Y++  TL +       +G + C A+N  G  + + 
Sbjct: 244 STWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTT 303

Query: 292 FFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLG-PFSDHQPE-P 349
              VV+  ++N+    N    V  GE ++L V  EA+P  +   W Y+   F+D   + P
Sbjct: 304 TLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYP 363

Query: 350 KLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWT 409
           K  N   +   R+   L L RLK +E G Y+FL  N     A+ F + +   PE+     
Sbjct: 364 KSEN---ESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR 420

Query: 410 FINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQ 469
            +NG   L C A+G+P+P + W  C G   RC  A VL V  D      S  PF K+ VQ
Sbjct: 421 LVNGM--LQCVAAGFPEPTIDWYFCPGTEQRCS-ASVLPV--DVQTLNSSGPPFGKLVVQ 475

Query: 470 SLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALL 529
           S +     +HN T EC+A+N VG  S A+   +     HP    LFTP+++  + +  ++
Sbjct: 476 SSIDSSAFKHNGTVECKAYNDVGKTS-AYFNFAFKEQIHP--HTLFTPLLIGFVIVAGMM 532

Query: 530 LLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLG 589
            +++++L YKY QKP Y+V+WK++E   GN+Y +IDPTQLPY+ KWEFPRN L FGKTLG
Sbjct: 533 CIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLG 592

Query: 590 AGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNL 649
           AGAFGKVVEATA+GL K DA + VAVKMLK +AH  E+EALMSELK++S+LG H NIVNL
Sbjct: 593 AGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNL 652

Query: 650 LGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYV 709
           LGACT GGP LVITEYCCYGDLLNFLRRK ++ +    S  +D      YKN+   K+  
Sbjct: 653 LGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFI---CSKQEDHAEAALYKNLLHSKESS 709

Query: 710 RRDSGFSSQGVDTYVEMRP-----VSTSSND-------SFSEQDLD----KEDGRPLELR 753
             DS       + Y++M+P     V T ++        S+ E+D+     ++D   L+L 
Sbjct: 710 CSDS------TNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLE 763

Query: 754 DLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKG 813
           DLL FS QVA+GMAFLASKNCIHRD+AARN+LLT+G + KI DFGLARDI NDSNY+VKG
Sbjct: 764 DLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKG 823

Query: 814 NARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGY 873
           NARLPVKWMAPESIF+CVYT +SDVWSYGI LWE+FSLG +PYPG+ V+SKFYK++K+G+
Sbjct: 824 NARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGF 883

Query: 874 QMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSS 930
           +M  P  AP  +Y IM+ CW  +P  RPTF+QI   +++Q  E      Y+NL + S
Sbjct: 884 RMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISES-TNHIYSNLANCS 939


>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
           homolog isoform 1 precursor [Homo sapiens]
          Length = 976

 Score =  666 bits (1718), Expect = 0.0
 Identities = 401/960 (41%), Positives = 552/960 (57%), Gaps = 64/960 (6%)

Query: 5   VLLLLLVATAWHGQGIPVIEPSVP-------ELVVKPGATVTLRCVGNGSVEWDGPPSPH 57
           +LLLL V T      +   EPS P       +L+V+ G  + L C   G V+W       
Sbjct: 14  LLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDE 73

Query: 58  WTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVV 117
               ++   +   T  A   NTG Y CT      G S +I+++V+DPA+ + ++ + +  
Sbjct: 74  T---NENKQNEWITEKAEATNTGKYTCTNKH---GLSNSIYVFVRDPAKLF-LVDRSLYG 126

Query: 118 FEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQ-DYQ 176
            ED D L+ C LTDP +    SL   +G+PL +   +   P  G  I   K    +    
Sbjct: 127 KEDNDTLVRCPLTDPEV-TNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLH 185

Query: 177 CSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVF 236
           CS    G+ V+S    LKV+      P +++  A  +   GE   + C+    DV+  V+
Sbjct: 186 CSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIK--DVSSSVY 243

Query: 237 L----QHNNTKLAIPQQSDFHNN-RYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSM 291
                +++ TKL     S  H +  Y++  TL +       +G + C A+N  G  + + 
Sbjct: 244 STWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTT 303

Query: 292 FFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLG-PFSDHQPE-P 349
              VV+  ++N+    N    V  GE ++L V  EA+P  +   W Y+   F+D   + P
Sbjct: 304 TLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYP 363

Query: 350 KLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWT 409
           K  N   +   R+   L L RLK +E G Y+FL  N     A+ F + +   PE+     
Sbjct: 364 KSEN---ESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR 420

Query: 410 FINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQ 469
            +NG   L C A+G+P+P + W  C G   RC  A VL V  D      S  PF K+ VQ
Sbjct: 421 LVNGM--LQCVAAGFPEPTIDWYFCPGTEQRCS-ASVLPV--DVQTLNSSGPPFGKLVVQ 475

Query: 470 SLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHT---HPPDEFLFTPVVVACMSIM 526
           S +     +HN T EC+A+N VG  S  F     G +    HP    LFTP+++  + + 
Sbjct: 476 SSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHP--HTLFTPLLIGFVIVA 533

Query: 527 ALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGK 586
            ++ +++++L YKY QKP Y+V+WK++E   GN+Y +IDPTQLPY+ KWEFPRN L FGK
Sbjct: 534 GMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGK 593

Query: 587 TLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENI 646
           TLGAGAFGKVVEATA+GL K DA + VAVKMLK +AH  E+EALMSELK++S+LG H NI
Sbjct: 594 TLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNI 653

Query: 647 VNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEK 706
           VNLLGACT GGP LVITEYCCYGDLLNFLRRK ++ +    S  +D      YKN+   K
Sbjct: 654 VNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFI---CSKQEDHAEAALYKNLLHSK 710

Query: 707 KYVRRDSGFSSQGVDTYVEMRP-----VSTSSND-------SFSEQDLD----KEDGRPL 750
           +    DS       + Y++M+P     V T ++        S+ E+D+     ++D   L
Sbjct: 711 ESSCSDS------TNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELAL 764

Query: 751 ELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYI 810
           +L DLL FS QVA+GMAFLASKNCIHRD+AARN+LLT+G + KI DFGLARDI NDSNY+
Sbjct: 765 DLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYV 824

Query: 811 VKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVK 870
           VKGNARLPVKWMAPESIF+CVYT +SDVWSYGI LWE+FSLG +PYPG+ V+SKFYK++K
Sbjct: 825 VKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIK 884

Query: 871 DGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSS 930
           +G++M  P  AP  +Y IM+ CW  +P  RPTF+QI   +++Q  E      Y+NL + S
Sbjct: 885 EGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISES-TNHIYSNLANCS 943


>gi|5453870 platelet-derived growth factor receptor alpha precursor
           [Homo sapiens]
          Length = 1089

 Score =  492 bits (1267), Expect = e-139
 Identities = 327/954 (34%), Positives = 488/954 (51%), Gaps = 91/954 (9%)

Query: 20  IPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWT----LYSDGSSS-----ILS 70
           +P I P+  E VV+  ++ +LRC G   V W  P S   +    + ++ ++S     +L 
Sbjct: 27  LPSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLE 86

Query: 71  TNNATFQNTGTYRC------TEPGDPLGGSAAIHLYVKDPAR---PWNVLAQEVVVFEDQ 121
            ++A+  +TG Y C      TE  +  G    I++YV DP     P  +    V+V +D 
Sbjct: 87  VSSASAAHTGLYTCYYNHTQTEENELEGRH--IYIYVPDPDVAFVPLGMTDYLVIVEDDD 144

Query: 122 DALLPCLLTDPVLEAGVSLVRVRGR-PLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSAL 180
            A++PC  TDP  E  V+L    G  P    +   F+    FT+          Y C A 
Sbjct: 145 SAIIPCRTTDP--ETPVTLHNSEGVVPASYDSRQGFNGT--FTVG--------PYICEAT 192

Query: 181 MGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHN 240
           + G+K  +I   +   K       L +   + V   GE   + C+  + +V    +    
Sbjct: 193 VKGKKFQTIPFNVYALKAT-SELDLEMEALKTVYKSGETIVVTCAVFNNEVVDLQWTYPG 251

Query: 241 NTK-LAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNV--QGKHSTSMFFRVVE 297
             K   I    +      + V TL + +   + +G+Y C A     + K    +   V E
Sbjct: 252 EVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHE 311

Query: 298 SAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTK 357
             ++ +    + ++ V + E  +  V V AYP  +  +W                +    
Sbjct: 312 KGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPR-ISWLKNNLTLIENLTEITTDVEKI 370

Query: 358 DTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSG-- 415
              R+   L L R K  ++G Y+ +A+N    ++ TFEL  + P  +  +    +GS   
Sbjct: 371 QEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGG 430

Query: 416 -TLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQ-EPFHKVTVQSLLT 473
            T+ C A G P P++ W+ C     +C+      +  +    ++++     + TV+  +T
Sbjct: 431 QTVRCTAEGTPLPDIEWMICKD-IKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVT 489

Query: 474 VETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLL 533
              +E      C A N +G+ +     ++    +          V  A + ++ ++++ L
Sbjct: 490 FAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSE-------LTVAAAVLVLLVIVIISL 542

Query: 534 LLLLYKYKQKPKYQVRWKIIESY--EGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAG 591
           ++L+  +KQKP+Y++RW++IES   +G+ Y ++DP QLPY+ +WEFPR+ L  G+ LG+G
Sbjct: 543 IVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSG 602

Query: 592 AFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLG 651
           AFGKVVE TA+GL +   V+KVAVKMLK TA + EK+ALMSELKIM+HLG H NIVNLLG
Sbjct: 603 AFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLG 662

Query: 652 ACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGP------------SLSPGQDP------ 693
           ACT  GP+ +ITEYC YGDL+N+L +  ++ L               L+P  +       
Sbjct: 663 ACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVI 722

Query: 694 ---EGGVDYKNIH----------LEKKYVRRDSGFSSQGVDTYVEMRPVS---TSSNDSF 737
              E   DY ++           LE+K V + S       D     RP S    S  DS 
Sbjct: 723 LSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYD-----RPASYKKKSMLDSE 777

Query: 738 SEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDF 797
            +  L  ++   L L DLL F+ QVA+GM FLASKNC+HRD+AARNVLL  G + KI DF
Sbjct: 778 VKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDF 837

Query: 798 GLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYP 857
           GLARDIM+DSNY+ KG+  LPVKWMAPESIFD +YT  SDVWSYGILLWEIFSLG  PYP
Sbjct: 838 GLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYP 897

Query: 858 GILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQ 911
           G++V+S FY  +K GY+MA+P  A   +Y IM  CW  EP  RP+F  +   ++
Sbjct: 898 GMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVE 951


>gi|4505683 platelet-derived growth factor receptor beta precursor
           [Homo sapiens]
          Length = 1106

 Score =  491 bits (1265), Expect = e-138
 Identities = 346/984 (35%), Positives = 497/984 (50%), Gaps = 99/984 (10%)

Query: 5   VLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDG---PPSPHWTLY 61
           +L LLL+      QG+ V+ P  PELV+   +T  L C G+  V W+     P       
Sbjct: 18  LLSLLLLLEPQISQGL-VVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKA 76

Query: 62  SDGS-SSILSTNNATFQNTGTYRCTEP---GDPLGGSAAIHLYVKDPARPWNVL-AQEVV 116
            DG+ SS+L+  N T  +TG Y CT     G        ++++V DP   +    A+E+ 
Sbjct: 77  QDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELF 136

Query: 117 VF--EDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQD 174
           +F  E  +  +PC +TDP L   V+L   +G   +      +    GF+       + + 
Sbjct: 137 IFLTEITEITIPCRVTDPQLV--VTLHEKKGDVALP---VPYDHQRGFS----GIFEDRS 187

Query: 175 YQCSALMGGRKVMSISI---RLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDV 231
           Y C   +G R+V S +    RL+V  +     A+  V  +     GE   ++C     +V
Sbjct: 188 YICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQ-----GENITLMCIVIGNEV 242

Query: 232 -NFD-VFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHST 289
            NF+  + +  + +L  P      +  Y     L++   + + +G Y+C  +     H  
Sbjct: 243 VNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQD 302

Query: 290 --SMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQP 347
             ++   VVES Y+ L  E   +Q   +     L+V+ EAYP      +       D   
Sbjct: 303 EKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSA 362

Query: 348 -EPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSV 406
            E  L+     +T R+   L+L R+K +EAG Y+  A +      L+F+L +  P  V  
Sbjct: 363 GEIALSTRNVSET-RYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLE 421

Query: 407 IWTFINGSG--TLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPE-------V 457
           +      SG  T+ C   G PQPN+ W  C     RC       +  +   E       V
Sbjct: 422 LSESHPDSGEQTVRCRGRGMPQPNIIWSACRD-LKRCPRELPPTLLGNSSEEESQLETNV 480

Query: 458 LSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTP 517
              E   +  V S L ++ ++   +  C   N+VG  +   I +        P    F  
Sbjct: 481 TYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVV--------PHSLPFKV 532

Query: 518 VVV-ACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESY--EGNSYTFIDPTQLPYNEK 574
           VV+ A ++++ L ++ L++L+  +++KP+Y++RWK+IES   +G+ Y ++DP QLPY+  
Sbjct: 533 VVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDST 592

Query: 575 WEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSEL 634
           WE PR+ L  G+TLG+GAFG+VVEATA GL    A +KVAVKMLKSTA + EK+ALMSEL
Sbjct: 593 WELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSEL 652

Query: 635 KIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDP- 693
           KIMSHLG H N+VNLLGACT GGP+ +ITEYC YGDL+++L R     L       + P 
Sbjct: 653 KIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPS 712

Query: 694 ------------------------EGG---------VDYK---NIHLEKKYVRRDSGFSS 717
                                   +GG         VDY    ++  + KY   +S    
Sbjct: 713 AELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYM 772

Query: 718 QGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHR 777
              D YV   P  T      +E  +       L   DL+ FS QVA GM FLASKNC+HR
Sbjct: 773 APYDNYVPSAPERTCRATLINESPV-------LSYMDLVGFSYQVANGMEFLASKNCVHR 825

Query: 778 DVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSD 837
           D+AARNVL+  G + KI DFGLARDIM DSNYI KG+  LP+KWMAPESIF+ +YT  SD
Sbjct: 826 DLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSD 885

Query: 838 VWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEP 897
           VWS+GILLWEIF+LG  PYP + +N +FY  +K GY+MAQPA A   IY IMQ CW  + 
Sbjct: 886 VWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKF 945

Query: 898 THRPTFQQICSFLQEQAQEDRRER 921
             RP F Q+   L+    E  +++
Sbjct: 946 EIRPPFSQLVLLLERLLGEGYKKK 969


>gi|121114304 fms-related tyrosine kinase 3 [Homo sapiens]
          Length = 993

 Score =  444 bits (1142), Expect = e-124
 Identities = 279/753 (37%), Positives = 404/753 (53%), Gaps = 81/753 (10%)

Query: 206 TLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIP---QQSDFHNNRYQ-KVL 261
           T +P   +++ GE   I C A  V+  F +  +  N  L      + S +  NR   ++L
Sbjct: 255 TTLPQLFLKV-GEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRIL 313

Query: 262 TLNLDQVDFQHAGNYSCVASNVQGKH-STSMFFRVVESAYLNLSSEQNLIQEVTVGEGLN 320
              +  V     G Y+C +S    KH S S    +VE  ++N ++      E+   E   
Sbjct: 314 FAFVSSVARNDTGYYTCSSS----KHPSQSALVTIVEKGFINATNSSE-DYEIDQYEEFC 368

Query: 321 LKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYS 380
             V  +AYP ++   WT+           + +    +    + +++S       + G Y 
Sbjct: 369 FSVRFKAYPQIR-CTWTF----------SRKSFPCEQKGLDNGYSISKFCNHKHQPGEYI 417

Query: 381 FLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDR 440
           F A N        F L +R  P+V    +    S    C + GYP P+ TW +CS  +  
Sbjct: 418 FHAENDDAQFTKMFTLNIRRKPQVLAEASASQAS----CFSDGYPLPSWTWKKCSDKSPN 473

Query: 441 CDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIP 500
           C E     VW+       +++ F +    S L +         +C A+NS+G+     + 
Sbjct: 474 CTEEITEGVWN----RKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILL 529

Query: 501 ISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIE--SYEG 558
            S G      D   F   +  C+     +++L LL+ +KYK++ +Y+ + ++++      
Sbjct: 530 NSPGPFPFIQDNISFYATIGVCL---LFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSD 586

Query: 559 NSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML 618
           N Y ++D  +  Y+ KWEFPR NL+FGK LG+GAFGKV+ ATA+G+ K    ++VAVKML
Sbjct: 587 NEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKML 646

Query: 619 KSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRK 678
           K  A + E+EALMSELK+M+ LG HENIVNLLGACT  GP+ +I EYCCYGDLLN+LR K
Sbjct: 647 KEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSK 706

Query: 679 AEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFS---------------SQGVDTY 723
            E                      H     + ++  FS               S+ V  +
Sbjct: 707 RE--------------------KFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIH 746

Query: 724 VEMRPVSTSSNDSFSEQDL----------DKEDGRPLELRDLLHFSSQVAQGMAFLASKN 773
            +   +S    +SF  +D           ++ED   L   DLL F+ QVA+GM FL  K+
Sbjct: 747 PDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKS 806

Query: 774 CIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYT 833
           C+HRD+AARNVL+T+G V KI DFGLARDIM+DSNY+V+GNARLPVKWMAPES+F+ +YT
Sbjct: 807 CVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYT 866

Query: 834 VQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACW 893
           ++SDVWSYGILLWEIFSLG+NPYPGI V++ FYKL+++G++M QP +A + IY IMQ+CW
Sbjct: 867 IKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCW 926

Query: 894 ALEPTHRPTFQQICSFLQEQAQEDRRERDYTNL 926
           A +   RP+F  + SFL  Q   D  E  Y N+
Sbjct: 927 AFDSRKRPSFPNLTSFLGCQL-ADAEEAMYQNV 958



 Score = 39.3 bits (90), Expect = 0.018
 Identities = 30/139 (21%), Positives = 59/139 (42%), Gaps = 19/139 (13%)

Query: 312 EVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRL 371
           EV V   + L+V+V+A PG     W +     + QP   L N       R   ++ + ++
Sbjct: 82  EVDVSASITLQVLVDA-PGNISCLWVFKHSSLNCQPHFDLQN-------RGVVSMVILKM 133

Query: 372 KPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTF-------INGSGTLLCAASGY 424
             ++AG Y    ++      + F +++R     ++++T        +     L+C +   
Sbjct: 134 TETQAGEYLLFIQSEATNYTILFTVSIRN----TLLYTLRRPYFRKMENQDALVCISESV 189

Query: 425 PQPNVTWLQCSGHTDRCDE 443
           P+P V W+ C    + C E
Sbjct: 190 PEPIVEWVLCDSQGESCKE 208


>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [Homo
            sapiens]
          Length = 1338

 Score =  361 bits (927), Expect = 2e-99
 Identities = 256/756 (33%), Positives = 383/756 (50%), Gaps = 69/756 (9%)

Query: 218  EAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYS 277
            EA    CS +      D      N   +I Q+      + +   TL +   D + +G Y 
Sbjct: 477  EARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVV--ADSRISGIYI 534

Query: 278  CVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWT 337
            C+ASN  G    ++ F + +   +      NL +  T GE L L   V  +   +   W 
Sbjct: 535  CIASNKVGTVGRNISFYITD---VPNGFHVNLEKMPTEGEDLKLSCTVNKFL-YRDVTWI 590

Query: 338  YLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPS--EAGRYSFLARN--PGGWRALT 393
             L   ++      ++      T  H+ TL+L  +  S  ++G Y+  ARN   G      
Sbjct: 591  LLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQK 650

Query: 394  FELTLRYPPEVSVIWTF------INGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVL 447
             E+T+R      ++         I+ S TL C A+G P+P +TW + + H  + +   +L
Sbjct: 651  KEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFK-NNHKIQQEPGIIL 709

Query: 448  QVWDDPYPEVLSQEPFHKVTVQSLLTVE--TLEHNQTYECRAHNSVGS-GSWAFIPISAG 504
                                  S L +E  T E    Y C+A N  GS  S A++ +   
Sbjct: 710  GPGS------------------STLFIERVTEEDEGVYHCKATNQKGSVESSAYLTVQGT 751

Query: 505  AHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFI 564
            +     D+     + + C  + A L  LLL L  +  ++   +++   +          +
Sbjct: 752  S-----DKSNLELITLTCTCVAATLFWLLLTLFIRKMKRSSSEIKTDYLS-------IIM 799

Query: 565  DPTQLPYNE----------KWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVA 614
            DP ++P +E          KWEF R  L+ GK+LG GAFGKVV+A+AFG+ K      VA
Sbjct: 800  DPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVA 859

Query: 615  VKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACT-HGGPVLVITEYCCYGDLLN 673
            VKMLK  A A E +ALM+ELKI++H+G H N+VNLLGACT  GGP++VI EYC YG+L N
Sbjct: 860  VKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSN 919

Query: 674  FLRRKAEAM-LGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTS 732
            +L+ K +   L    +   +P+       +   KK  R DS  SS+   +       S S
Sbjct: 920  YLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKK-PRLDSVTSSESFASSGFQEDKSLS 978

Query: 733  SNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVA 792
              D   E+D D     P+ + DL+ +S QVA+GM FL+S+ CIHRD+AARN+LL+  +V 
Sbjct: 979  --DVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVV 1036

Query: 793  KIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLG 852
            KI DFGLARDI  + +Y+ KG+ RLP+KWMAPESIFD +Y+ +SDVWSYG+LLWEIFSLG
Sbjct: 1037 KICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLG 1096

Query: 853  LNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTF----QQICS 908
             +PYPG+ ++  F   +++G +M  P ++   IY IM  CW  +P  RP F    +++  
Sbjct: 1097 GSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGD 1156

Query: 909  FLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEE 944
             LQ   Q+D ++    N   +  SG + S+ +  E+
Sbjct: 1157 LLQANVQQDGKDYIPINAILTGNSGFTYSTPAFSED 1192



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 98/459 (21%), Positives = 186/459 (40%), Gaps = 66/459 (14%)

Query: 31  VVKPGATVTLRCVGNGSVEWDGPP-----SPHWTLYSDGSS-------SILSTNNATFQN 78
           +++ G T+ L+C G  + +W  P      S   ++             S L+ N A   +
Sbjct: 42  IMQAGQTLHLQCRGEAAHKWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANH 101

Query: 79  TGTYRCTEPGDPLGGS----AAIHLYVKDPARPWNVLAQEVV----VFEDQDALLPCLLT 130
           TG Y C     P        +AI++++ D  RP+  +  E+     + E ++ ++PC +T
Sbjct: 102 TGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVT 161

Query: 131 DPVLEAGVSLVRVRGRPLMRH-TNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSI 189
            P +   V+L +     L+       +    GF I  A + +     C A + G    + 
Sbjct: 162 SPNIT--VTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTN 219

Query: 190 SIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDV-----FLQHNNTKL 244
            +  +    I      T  P +L  +RG    + C+A++  +N  V     +    N + 
Sbjct: 220 YLTHRQTNTIIDVQISTPRPVKL--LRGHTLVLNCTATT-PLNTRVQMTWSYPDEKNKRA 276

Query: 245 AIPQ---QSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYL 301
           ++ +   QS+ H N +  VLT+  D++  +  G Y+C   +     S +    + + A++
Sbjct: 277 SVRRRIDQSNSHANIFYSVLTI--DKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFI 334

Query: 302 NLSSEQNLIQEVTVGE-GLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTY 360
            +   +  + E   G+    L + V+A+P  +   W       D  P      AT K   
Sbjct: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVV-W-----LKDGLP------ATEKSAR 382

Query: 361 RHT--FTLSLPRLKPSEAGRYSFLA--RNPGGWRALTFELTLRYPPEV--SVIWTF---- 410
             T  ++L +  +   +AG Y+ L   +    ++ LT  L +   P++    + +F    
Sbjct: 383 YLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPA 442

Query: 411 ---INGSGTLLCAASGYPQPNVTWL--QCS-GHTD-RCD 442
              +     L C A G PQP + W    C+  H++ RCD
Sbjct: 443 LYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCD 481


>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
          Length = 1356

 Score =  340 bits (871), Expect = 5e-93
 Identities = 225/581 (38%), Positives = 315/581 (54%), Gaps = 63/581 (10%)

Query: 409  TFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTV 468
            T I  S  + C ASG P P + W +    T   D   VL+            +    +T+
Sbjct: 678  TSIGESIEVSCTASGNPPPQIMWFK-DNETLVEDSGIVLK------------DGNRNLTI 724

Query: 469  QSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMAL 528
            + +      E    Y C+A + +G        I  GA      E +   ++V    I   
Sbjct: 725  RRVRK----EDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEII---ILVGTAVIAMF 777

Query: 529  LLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNE----------KWEFP 578
              LLL+++L   K+    +++        G     +DP +LP +E          KWEFP
Sbjct: 778  FWLLLVIILRTVKRANGGELK-------TGYLSIVMDPDELPLDEHCERLPYDASKWEFP 830

Query: 579  RNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMS 638
            R+ L+ GK LG GAFG+V+EA AFG+ K      VAVKMLK  A   E  ALMSELKI+ 
Sbjct: 831  RDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILI 890

Query: 639  HLGQHENIVNLLGACTH-GGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGV 697
            H+G H N+VNLLGACT  GGP++VI E+C +G+L  +LR K    + P  + G     G 
Sbjct: 891  HIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFV-PYKTKGARFRQGK 949

Query: 698  DYKNIHLEKKYVRRDSGFSSQGVDT--YVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDL 755
            DY          R DS  SSQ   +  +VE + +S    +   E DL K+    L L  L
Sbjct: 950  DYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPE-DLYKDF---LTLEHL 1005

Query: 756  LHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNA 815
            + +S QVA+GM FLAS+ CIHRD+AARN+LL+  +V KI DFGLARDI  D +Y+ KG+A
Sbjct: 1006 ICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDA 1065

Query: 816  RLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQM 875
            RLP+KWMAPE+IFD VYT+QSDVWS+G+LLWEIFSLG +PYPG+ ++ +F + +K+G +M
Sbjct: 1066 RLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRM 1125

Query: 876  AQPAFAPKNIYSIMQACWALEPTHRPTFQQIC----SFLQEQAQEDRRERDYTNLPSSSR 931
              P +    +Y  M  CW  EP+ RPTF ++     + LQ  AQ+D   +DY  LP    
Sbjct: 1126 RAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQD--GKDYIVLPI--- 1180

Query: 932  SGGSGSSSSELEEESS----SEHLTCCEQGDIAQPLLQPNN 968
                 S +  +EE+S     +  ++C E+ ++  P    +N
Sbjct: 1181 -----SETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDN 1216



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 126/553 (22%), Positives = 212/553 (38%), Gaps = 85/553 (15%)

Query: 5   VLLLLLVATAWHGQGIPVIEPSVPEL-------VVKPGATVTLRCVGNGSVEWDGPPSPH 57
           V L L V T     G+P +   +P L        +K   T+ + C G   ++W  P +  
Sbjct: 9   VALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQS 68

Query: 58  W-------TLYSDGS-SSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPW- 108
                   T  SDG     L+       +TG Y+C      L  ++ I++YV+D   P+ 
Sbjct: 69  GSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDL--ASVIYVYVQDYRSPFI 126

Query: 109 -NVLAQEVVVF----EDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFT 163
            +V  Q  VV+    +++  ++PCL +   L   +       R +      S+    GFT
Sbjct: 127 ASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFT 186

Query: 164 IHRAKFIQSQDYQCSALMGGRKVMSIS-----IRLKVQKVIPGPPALTLVPAELVRIR-G 217
           I       +    C A +      SI      +  ++  V+       L P+  + +  G
Sbjct: 187 IPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVV-------LSPSHGIELSVG 239

Query: 218 EAAQIVCSASS-----VDVNFDV-FLQHNNTKLAIPQQSDFHNNRYQKVL-TLNLDQVDF 270
           E   + C+A +     +D N++    +H + KL          +  +K L TL +D V  
Sbjct: 240 EKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTR 299

Query: 271 QHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPG 330
              G Y+C AS+       S F RV E  ++   S    + E TVGE + +      YP 
Sbjct: 300 SDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPP 359

Query: 331 LQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNP--GG 388
            +   W   G        P  +N T K  +     L++  +   + G Y+ +  NP    
Sbjct: 360 PE-IKWYKNG-------IPLESNHTIKAGH----VLTIMEVSERDTGNYTVILTNPISKE 407

Query: 389 WRALTFELTLRYPPE------VSVIWTFING-SGTLLCAASGYPQP-NVTWLQCSGHTDR 440
            ++    L +  PP+      +S + ++  G + TL C     P P ++ W         
Sbjct: 408 KQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECA 467

Query: 441 CDEAQVLQVWDDPYP--EVLSQEPF---HKVTVQ--------------SLLTVETLEHNQ 481
            + +Q + V  +PYP  E  S E F   +K+ V               S L ++    + 
Sbjct: 468 NEPSQAVSV-TNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSA 526

Query: 482 TYECRAHNSVGSG 494
            Y+C A N VG G
Sbjct: 527 LYKCEAVNKVGRG 539


>gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor [Homo
            sapiens]
          Length = 1363

 Score =  337 bits (865), Expect = 2e-92
 Identities = 244/712 (34%), Positives = 348/712 (48%), Gaps = 91/712 (12%)

Query: 276  YSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFN 335
            Y CV SN  G+    ++F V        + E    +E+  G+ + L    ++Y   +   
Sbjct: 532  YKCVVSNKVGQDERLIYFYVTTIPD-GFTIESKPSEELLEGQPVLLSCQADSYK-YEHLR 589

Query: 336  W--TYLGPFSDHQPEPKLANATTKDTY---------------RH-TFTLSLPRLKPSEAG 377
            W    L    D    P L +      +               RH T +LS+PR+ P   G
Sbjct: 590  WYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIPRVAPEHEG 649

Query: 378  RYSFLARNPGGWRALTFELTL--------RYPPEVSVIWTFINGSGTLLCAASGYPQPNV 429
             Y    ++         +  L        R    ++ +   ++ S  + C  +G   P++
Sbjct: 650  HYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVAGAHAPSI 709

Query: 430  TW------LQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTY 483
             W      L+     D  D  Q                   K+++Q +      E    Y
Sbjct: 710  VWYKDERLLEEKSGVDLADSNQ-------------------KLSIQRVRE----EDAGRY 746

Query: 484  ECRAHNSVGS-GSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQ 542
             C   N+ G   S A + +         D+     V++    ++A+   +LLLL++   +
Sbjct: 747  LCSVCNAKGCVNSSASVAVEGSE-----DKGSMEIVILVGTGVIAVFFWVLLLLIFCNMR 801

Query: 543  KPKYQVRWKIIESYEGNSYTFIDPTQLPYNEK----------WEFPRNNLQFGKTLGAGA 592
            +P +       +   G     +DP ++P  E+          WEFPR  L  G+ LG GA
Sbjct: 802  RPAHA------DIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGA 855

Query: 593  FGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGA 652
            FGKVVEA+AFG+ K  +   VAVKMLK  A A E  ALMSELKI+ H+G H N+VNLLGA
Sbjct: 856  FGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGA 915

Query: 653  CTHG-GPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR 711
            CT   GP++VI E+C YG+L NFLR K +A    S    + PE    ++ +    +  RR
Sbjct: 916  CTKPQGPLMVIVEFCKYGNLSNFLRAKRDAF---SPCAEKSPEQRGRFRAMVELARLDRR 972

Query: 712  DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDG--RPLELRDLLHFSSQVAQGMAFL 769
              G S    D  +  R   T      +  D + ED    PL + DL+ +S QVA+GM FL
Sbjct: 973  RPGSS----DRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFL 1028

Query: 770  ASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFD 829
            AS+ CIHRD+AARN+LL+   V KI DFGLARDI  D +Y+ KG+ARLP+KWMAPESIFD
Sbjct: 1029 ASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFD 1088

Query: 830  CVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIM 889
             VYT QSDVWS+G+LLWEIFSLG +PYPG+ +N +F + ++DG +M  P  A   I  IM
Sbjct: 1089 KVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIM 1148

Query: 890  QACWALEPTHRPTFQQICSFLQE--QAQEDRRERDYTNLPSSSRSGGSGSSS 939
              CW+ +P  RP F ++   L +  Q +  + E +    P SS+S   GS S
Sbjct: 1149 LNCWSGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMAPRSSQSSEEGSFS 1200



 Score = 40.4 bits (93), Expect = 0.008
 Identities = 125/614 (20%), Positives = 222/614 (36%), Gaps = 114/614 (18%)

Query: 21  PVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSS------------- 67
           P +  +    V+  G ++++ C G   +EW  P +       D  S              
Sbjct: 30  PTLNITEESHVIDTGDSLSISCRGQHPLEWAWPGAQEAPATGDKDSEDTGVVRDCEGTDA 89

Query: 68  -----ILSTNNATFQNTGTYRC----TEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVF 118
                +L  +     +TG+Y C     +       +A+ +++V+D  +P+ +   + ++ 
Sbjct: 90  RPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAASSYVFVRDFEQPF-INKPDTLLV 148

Query: 119 EDQDAL-LPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPW---HGFTIHRAKFIQSQD 174
             +DA+ +PCL++ P L      V +R +  +   +     W    G  +       +  
Sbjct: 149 NRKDAMWVPCLVSIPGLN-----VTLRSQSSVLWPDGQEVVWDDRRGMLVSTPLLHDALY 203

Query: 175 YQCSALMGGRKVMSISIRLKVQKVIPGPPA--LTLVPAELVRIR-GEAAQIVCSA----- 226
            QC    G +  +S    +     I G     + L+P + + +  GE   + C+      
Sbjct: 204 LQCETTWGDQDFLSNPFLVH----ITGNELYDIQLLPRKSLELLVGEKLVLNCTVWAEFN 259

Query: 227 SSVDVNFDV-FLQHNNTKLAIPQQSDFHNNRYQKVLTL-NLDQVDFQHAGNYSCVASNVQ 284
           S V  ++D    Q    K    ++S   +     +LT+ N+ Q D    G+Y C A+N  
Sbjct: 260 SGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNVSQHDL---GSYVCKANNGI 316

Query: 285 GKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGL-NLKVMVEAYPGLQGFNWTYLGP-- 341
            +   S    V E+ ++++   +  I E T G+ L  L V + AYP  + F W   G   
Sbjct: 317 QRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLPVKLAAYPPPE-FQWYKDGKAL 375

Query: 342 FSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYP 401
              H P   +    T +    T+TL+L     S AG    L RN      ++ EL +  P
Sbjct: 376 SGRHSPHALVLKEVT-EASTGTYTLALWN---SAAG----LRRN------ISLELVVNVP 421

Query: 402 PEV------SVIWTFINGSGTLLCAASGYPQPNV------TWLQCSGHTDR--------- 440
           P++      S      +    L C A G P P         W  C     R         
Sbjct: 422 PQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCKMFAQRSLRRRQQQD 481

Query: 441 ----CDEAQVLQVWDDPYP----EVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVG 492
               C + + +   D   P    +  ++    K    S L ++    +  Y+C   N VG
Sbjct: 482 LMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNANVSAMYKCVVSNKVG 541

Query: 493 SGSWAF------IPISAGAHTHPPDEFL-FTPVVVACMSIMALLLLLLLLLLYKYKQKPK 545
                       IP      + P +E L   PV+++C +             YKY+    
Sbjct: 542 QDERLIYFYVTTIPDGFTIESKPSEELLEGQPVLLSCQADS-----------YKYEHLRW 590

Query: 546 YQVRWKIIESYEGN 559
           Y++    +    GN
Sbjct: 591 YRLNLSTLHDAHGN 604


>gi|103472027 fms-related tyrosine kinase 4 isoform 2 precursor [Homo
            sapiens]
          Length = 1298

 Score =  337 bits (865), Expect = 2e-92
 Identities = 244/712 (34%), Positives = 348/712 (48%), Gaps = 91/712 (12%)

Query: 276  YSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFN 335
            Y CV SN  G+    ++F V        + E    +E+  G+ + L    ++Y   +   
Sbjct: 532  YKCVVSNKVGQDERLIYFYVTTIPD-GFTIESKPSEELLEGQPVLLSCQADSYK-YEHLR 589

Query: 336  W--TYLGPFSDHQPEPKLANATTKDTY---------------RH-TFTLSLPRLKPSEAG 377
            W    L    D    P L +      +               RH T +LS+PR+ P   G
Sbjct: 590  WYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIPRVAPEHEG 649

Query: 378  RYSFLARNPGGWRALTFELTL--------RYPPEVSVIWTFINGSGTLLCAASGYPQPNV 429
             Y    ++         +  L        R    ++ +   ++ S  + C  +G   P++
Sbjct: 650  HYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVAGAHAPSI 709

Query: 430  TW------LQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTY 483
             W      L+     D  D  Q                   K+++Q +      E    Y
Sbjct: 710  VWYKDERLLEEKSGVDLADSNQ-------------------KLSIQRVRE----EDAGRY 746

Query: 484  ECRAHNSVGS-GSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQ 542
             C   N+ G   S A + +         D+     V++    ++A+   +LLLL++   +
Sbjct: 747  LCSVCNAKGCVNSSASVAVEGSE-----DKGSMEIVILVGTGVIAVFFWVLLLLIFCNMR 801

Query: 543  KPKYQVRWKIIESYEGNSYTFIDPTQLPYNEK----------WEFPRNNLQFGKTLGAGA 592
            +P +       +   G     +DP ++P  E+          WEFPR  L  G+ LG GA
Sbjct: 802  RPAHA------DIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGA 855

Query: 593  FGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGA 652
            FGKVVEA+AFG+ K  +   VAVKMLK  A A E  ALMSELKI+ H+G H N+VNLLGA
Sbjct: 856  FGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGA 915

Query: 653  CTHG-GPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR 711
            CT   GP++VI E+C YG+L NFLR K +A    S    + PE    ++ +    +  RR
Sbjct: 916  CTKPQGPLMVIVEFCKYGNLSNFLRAKRDAF---SPCAEKSPEQRGRFRAMVELARLDRR 972

Query: 712  DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDG--RPLELRDLLHFSSQVAQGMAFL 769
              G S    D  +  R   T      +  D + ED    PL + DL+ +S QVA+GM FL
Sbjct: 973  RPGSS----DRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFL 1028

Query: 770  ASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFD 829
            AS+ CIHRD+AARN+LL+   V KI DFGLARDI  D +Y+ KG+ARLP+KWMAPESIFD
Sbjct: 1029 ASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFD 1088

Query: 830  CVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIM 889
             VYT QSDVWS+G+LLWEIFSLG +PYPG+ +N +F + ++DG +M  P  A   I  IM
Sbjct: 1089 KVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIM 1148

Query: 890  QACWALEPTHRPTFQQICSFLQE--QAQEDRRERDYTNLPSSSRSGGSGSSS 939
              CW+ +P  RP F ++   L +  Q +  + E +    P SS+S   GS S
Sbjct: 1149 LNCWSGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMAPRSSQSSEEGSFS 1200



 Score = 40.4 bits (93), Expect = 0.008
 Identities = 125/614 (20%), Positives = 222/614 (36%), Gaps = 114/614 (18%)

Query: 21  PVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSS------------- 67
           P +  +    V+  G ++++ C G   +EW  P +       D  S              
Sbjct: 30  PTLNITEESHVIDTGDSLSISCRGQHPLEWAWPGAQEAPATGDKDSEDTGVVRDCEGTDA 89

Query: 68  -----ILSTNNATFQNTGTYRC----TEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVF 118
                +L  +     +TG+Y C     +       +A+ +++V+D  +P+ +   + ++ 
Sbjct: 90  RPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAASSYVFVRDFEQPF-INKPDTLLV 148

Query: 119 EDQDAL-LPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPW---HGFTIHRAKFIQSQD 174
             +DA+ +PCL++ P L      V +R +  +   +     W    G  +       +  
Sbjct: 149 NRKDAMWVPCLVSIPGLN-----VTLRSQSSVLWPDGQEVVWDDRRGMLVSTPLLHDALY 203

Query: 175 YQCSALMGGRKVMSISIRLKVQKVIPGPPA--LTLVPAELVRIR-GEAAQIVCSA----- 226
            QC    G +  +S    +     I G     + L+P + + +  GE   + C+      
Sbjct: 204 LQCETTWGDQDFLSNPFLVH----ITGNELYDIQLLPRKSLELLVGEKLVLNCTVWAEFN 259

Query: 227 SSVDVNFDV-FLQHNNTKLAIPQQSDFHNNRYQKVLTL-NLDQVDFQHAGNYSCVASNVQ 284
           S V  ++D    Q    K    ++S   +     +LT+ N+ Q D    G+Y C A+N  
Sbjct: 260 SGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNVSQHDL---GSYVCKANNGI 316

Query: 285 GKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGL-NLKVMVEAYPGLQGFNWTYLGP-- 341
            +   S    V E+ ++++   +  I E T G+ L  L V + AYP  + F W   G   
Sbjct: 317 QRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLPVKLAAYPPPE-FQWYKDGKAL 375

Query: 342 FSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYP 401
              H P   +    T +    T+TL+L     S AG    L RN      ++ EL +  P
Sbjct: 376 SGRHSPHALVLKEVT-EASTGTYTLALWN---SAAG----LRRN------ISLELVVNVP 421

Query: 402 PEV------SVIWTFINGSGTLLCAASGYPQPNV------TWLQCSGHTDR--------- 440
           P++      S      +    L C A G P P         W  C     R         
Sbjct: 422 PQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCKMFAQRSLRRRQQQD 481

Query: 441 ----CDEAQVLQVWDDPYP----EVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVG 492
               C + + +   D   P    +  ++    K    S L ++    +  Y+C   N VG
Sbjct: 482 LMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNANVSAMYKCVVSNKVG 541

Query: 493 SGSWAF------IPISAGAHTHPPDEFL-FTPVVVACMSIMALLLLLLLLLLYKYKQKPK 545
                       IP      + P +E L   PV+++C +             YKY+    
Sbjct: 542 QDERLIYFYVTTIPDGFTIESKPSEELLEGQPVLLSCQADS-----------YKYEHLRW 590

Query: 546 YQVRWKIIESYEGN 559
           Y++    +    GN
Sbjct: 591 YRLNLSTLHDAHGN 604


>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
           [Homo sapiens]
          Length = 802

 Score =  281 bits (719), Expect = 2e-75
 Identities = 210/643 (32%), Positives = 301/643 (46%), Gaps = 117/643 (18%)

Query: 364 FTLSLPRLKPSEAGRYSFLARNPGGWRALTFEL-TLRYPPEVSVIWTFINGSGT------ 416
           ++L +  + PS+ G Y+ L  N  G     + L  L   P   ++   +  + T      
Sbjct: 207 WSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSD 266

Query: 417 --LLCAASGYPQPNVTWLQ---CSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSL 471
             LLC      QP++ WL+    +G +   D          PY +VL     +   V+ L
Sbjct: 267 VELLCKVYSDAQPHIQWLKHIVINGSSFGADGF--------PYVQVLKTADINSSEVEVL 318

Query: 472 -LTVETLEHNQTYECRAHNSVG---SGSW-AFIPISAGAHTHPPDEFLFTPVVVACMSIM 526
            L   + E    Y C A NS+G     +W   +P      T    E  +T +++     +
Sbjct: 319 YLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSL 378

Query: 527 ALLLLLLLLLLYKYKQ------KPKYQVR----------WKIIESYEGNSYTFID----- 565
           AL +LLLL  LY+ +       +P   V+          + +     G S + +      
Sbjct: 379 ALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRL 438

Query: 566 ------------PTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGL--GKEDAVL 611
                          LP +  WEFPR+ L  GK LG G FG+VV A AFG+   + D   
Sbjct: 439 SSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQAS 498

Query: 612 KVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDL 671
            VAVKMLK  A   +   L+SE+++M  +G+H+NI+NLLG CT  GP+ VI E    G+L
Sbjct: 499 TVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNL 558

Query: 672 LNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVST 731
             FLR +     GP LSP                      D   SS+G            
Sbjct: 559 REFLRARRPP--GPDLSP----------------------DGPRSSEG------------ 582

Query: 732 SSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHV 791
                            PL    L+  + QVA+GM +L S+ CIHRD+AARNVL+T  +V
Sbjct: 583 -----------------PLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNV 625

Query: 792 AKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSL 851
            KI DFGLAR + +   Y    N RLPVKWMAPE++FD VYT QSDVWS+GILLWEIF+L
Sbjct: 626 MKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTL 685

Query: 852 GLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQ 911
           G +PYPGI V  + + L+++G++M +P   P  +Y +M+ CW   P+ RPTF+Q+   L 
Sbjct: 686 GGSPYPGIPV-EELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALD 744

Query: 912 E---QAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHL 951
           +      E+  +   T  P S   G + S+ S  +   S + L
Sbjct: 745 KVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPL 787


>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
           [Homo sapiens]
          Length = 802

 Score =  281 bits (719), Expect = 2e-75
 Identities = 210/643 (32%), Positives = 301/643 (46%), Gaps = 117/643 (18%)

Query: 364 FTLSLPRLKPSEAGRYSFLARNPGGWRALTFEL-TLRYPPEVSVIWTFINGSGT------ 416
           ++L +  + PS+ G Y+ L  N  G     + L  L   P   ++   +  + T      
Sbjct: 207 WSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSD 266

Query: 417 --LLCAASGYPQPNVTWLQ---CSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSL 471
             LLC      QP++ WL+    +G +   D          PY +VL     +   V+ L
Sbjct: 267 VELLCKVYSDAQPHIQWLKHIVINGSSFGADGF--------PYVQVLKTADINSSEVEVL 318

Query: 472 -LTVETLEHNQTYECRAHNSVG---SGSW-AFIPISAGAHTHPPDEFLFTPVVVACMSIM 526
            L   + E    Y C A NS+G     +W   +P      T    E  +T +++     +
Sbjct: 319 YLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSL 378

Query: 527 ALLLLLLLLLLYKYKQ------KPKYQVR----------WKIIESYEGNSYTFID----- 565
           AL +LLLL  LY+ +       +P   V+          + +     G S + +      
Sbjct: 379 ALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRL 438

Query: 566 ------------PTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGL--GKEDAVL 611
                          LP +  WEFPR+ L  GK LG G FG+VV A AFG+   + D   
Sbjct: 439 SSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQAS 498

Query: 612 KVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDL 671
            VAVKMLK  A   +   L+SE+++M  +G+H+NI+NLLG CT  GP+ VI E    G+L
Sbjct: 499 TVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNL 558

Query: 672 LNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVST 731
             FLR +     GP LSP                      D   SS+G            
Sbjct: 559 REFLRARRPP--GPDLSP----------------------DGPRSSEG------------ 582

Query: 732 SSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHV 791
                            PL    L+  + QVA+GM +L S+ CIHRD+AARNVL+T  +V
Sbjct: 583 -----------------PLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNV 625

Query: 792 AKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSL 851
            KI DFGLAR + +   Y    N RLPVKWMAPE++FD VYT QSDVWS+GILLWEIF+L
Sbjct: 626 MKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTL 685

Query: 852 GLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQ 911
           G +PYPGI V  + + L+++G++M +P   P  +Y +M+ CW   P+ RPTF+Q+   L 
Sbjct: 686 GGSPYPGIPV-EELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALD 744

Query: 912 E---QAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHL 951
           +      E+  +   T  P S   G + S+ S  +   S + L
Sbjct: 745 KVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPL 787


>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
           [Homo sapiens]
          Length = 806

 Score =  280 bits (715), Expect = 6e-75
 Identities = 210/646 (32%), Positives = 303/646 (46%), Gaps = 130/646 (20%)

Query: 364 FTLSLPRLKPSEAGRYSFLARNPGGWRALTFEL-TLRYPPEVSVIWTFINGSGTLL---- 418
           ++L +  + PS+ G Y+ +  N  G    T+ L  L   P   ++   +  + T +    
Sbjct: 211 WSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSD 270

Query: 419 ----CAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTV 474
               C      QP++ WL+   H     E    +V  D  P V   +     T    L V
Sbjct: 271 VEFHCKVYSDAQPHIQWLK---HV----EVNGSKVGPDGTPYVTVLKTAGANTTDKELEV 323

Query: 475 ETLEHNQTYE------CRAHNSVG---SGSWAFIPISAGAHTHPPDEF--LFTPVVVACM 523
            +L HN T+E      C A NS+G     +W  + + A       DE   ++  ++   +
Sbjct: 324 LSL-HNVTFEDAGEYTCLAGNSIGFSHHSAWLVV-LPAEEELVEADEAGSVYAGILSYGV 381

Query: 524 SIMALLLLLLLLLLYKYKQKPKYQ--------------------------------VRWK 551
                +L++  + L + +  PK                                  VR  
Sbjct: 382 GFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIA 441

Query: 552 IIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAV- 610
            + S EG +   +   +LP + KWE  R  L  GK LG G FG+VV A A G+ K+ A  
Sbjct: 442 RLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAK 501

Query: 611 -LKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYG 669
            + VAVKMLK  A   +   L+SE+++M  +G+H+NI+NLLGACT GGP+ V+ EY   G
Sbjct: 502 PVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKG 561

Query: 670 DLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPV 729
           +L  FLR +                 G+DY                              
Sbjct: 562 NLREFLRARRPP--------------GLDY------------------------------ 577

Query: 730 STSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNG 789
                 SF   D  K     L  +DL+  + QVA+GM +LAS+ CIHRD+AARNVL+T  
Sbjct: 578 ------SF---DTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTED 628

Query: 790 HVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIF 849
           +V KI DFGLARD+ N   Y    N RLPVKWMAPE++FD VYT QSDVWS+G+LLWEIF
Sbjct: 629 NVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIF 688

Query: 850 SLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQIC-- 907
           +LG +PYPGI V  + +KL+K+G++M +PA    ++Y IM+ CW   P+ RPTF+Q+   
Sbjct: 689 TLGGSPYPGIPV-EELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVED 747

Query: 908 -----------SFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSEL 942
                       +L   A  ++      + PSSS SG     + +L
Sbjct: 748 LDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDL 793


>gi|254028242 fibroblast growth factor receptor 3 isoform 3
           precursor [Homo sapiens]
          Length = 808

 Score =  278 bits (712), Expect = 1e-74
 Identities = 209/646 (32%), Positives = 299/646 (46%), Gaps = 128/646 (19%)

Query: 364 FTLSLPRLKPSEAGRYSFLARNPGGWRALTFEL-TLRYPPEVSVIWTFINGSGTLL---- 418
           ++L +  + PS+ G Y+ +  N  G    T+ L  L   P   ++   +  + T +    
Sbjct: 211 WSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSD 270

Query: 419 ----CAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDD--PYPEVLSQEPFHKVTVQSLL 472
               C      QP++ WL+   H     E    +V  D  PY  VL       V     L
Sbjct: 271 VEFHCKVYSDAQPHIQWLK---HV----EVNGSKVGPDGTPYVTVLKSWISESVEADVRL 323

Query: 473 TVETLEHNQ--TYECRAHNSVGSGSWAFI-----PISAGAHTHPPDEF--LFTPVVVACM 523
            +  +       Y CRA N +G    AF      P +A       DE   ++  ++   +
Sbjct: 324 RLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSYGV 383

Query: 524 SIMALLLLLLLLLLYKYKQKPKYQ--------------------------------VRWK 551
                +L++  + L + +  PK                                  VR  
Sbjct: 384 GFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIA 443

Query: 552 IIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAV- 610
            + S EG +   +   +LP + KWE  R  L  GK LG G FG+VV A A G+ K+ A  
Sbjct: 444 RLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAK 503

Query: 611 -LKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYG 669
            + VAVKMLK  A   +   L+SE+++M  +G+H+NI+NLLGACT GGP+ V+ EY   G
Sbjct: 504 PVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKG 563

Query: 670 DLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPV 729
           +L  FLR +                 G+DY                              
Sbjct: 564 NLREFLRARRPP--------------GLDY------------------------------ 579

Query: 730 STSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNG 789
                 SF   D  K     L  +DL+  + QVA+GM +LAS+ CIHRD+AARNVL+T  
Sbjct: 580 ------SF---DTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTED 630

Query: 790 HVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIF 849
           +V KI DFGLARD+ N   Y    N RLPVKWMAPE++FD VYT QSDVWS+G+LLWEIF
Sbjct: 631 NVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIF 690

Query: 850 SLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQIC-- 907
           +LG +PYPGI V  + +KL+K+G++M +PA    ++Y IM+ CW   P+ RPTF+Q+   
Sbjct: 691 TLGGSPYPGIPV-EELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVED 749

Query: 908 -----------SFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSEL 942
                       +L   A  ++      + PSSS SG     + +L
Sbjct: 750 LDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDL 795


>gi|222144237 fibroblast growth factor receptor 2 isoform 6
           precursor [Homo sapiens]
          Length = 706

 Score =  276 bits (706), Expect = 7e-74
 Identities = 206/673 (30%), Positives = 317/673 (47%), Gaps = 142/673 (21%)

Query: 364 FTLSLPRLKPSEAGRYSFLARNPGGWRALTFEL-TLRYPPEVSVIW--------TFINGS 414
           ++L +  + PS+ G Y+ +  N  G    T+ L  +   P   ++         T + G 
Sbjct: 99  WSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGD 158

Query: 415 GTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDD--PYPEVLSQEPFH----KVTV 468
              +C      QP++ W++   H ++       +   D  PY +VL     +    ++ V
Sbjct: 159 VEFVCKVYSDAQPHIQWIK---HVEKNGS----KYGPDGLPYLKVLKAAGVNTTDKEIEV 211

Query: 469 QSLLTVETLEHNQTYECRAHNSVG---SGSWAFIPISAGAH---THPPDEFLFTPVVVAC 522
             +  V T E    Y C A NS+G     +W  +  + G     T  PD   +  + + C
Sbjct: 212 LYIRNV-TFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPD---YLEIAIYC 267

Query: 523 MSIMALLLLLLLLLLYKYK---QKPKYQ-------------VRWKIIESYEGNS------ 560
           + +  +  +++ ++L + K   +KP +              +R ++  S E +S      
Sbjct: 268 IGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNT 327

Query: 561 -----------------YTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFG 603
                               +   +LP + KWEFPR+ L  GK LG G FG+VV A A G
Sbjct: 328 PLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVG 387

Query: 604 LGKEDA--VLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLV 661
           + K+     + VAVKMLK  A   +   L+SE+++M  +G+H+NI+NLLGACT  GP+ V
Sbjct: 388 IDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYV 447

Query: 662 ITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVD 721
           I EY   G+L  +LR +                 G++Y                      
Sbjct: 448 IVEYASKGNLREYLRARRPP--------------GMEYS--------------------- 472

Query: 722 TYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAA 781
                              D+++     +  +DL+  + Q+A+GM +LAS+ CIHRD+AA
Sbjct: 473 ------------------YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 514

Query: 782 RNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSY 841
           RNVL+T  +V KI DFGLARDI N   Y    N RLPVKWMAPE++FD VYT QSDVWS+
Sbjct: 515 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 574

Query: 842 GILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRP 901
           G+L+WEIF+LG +PYPGI V  + +KL+K+G++M +PA     +Y +M+ CW   P+ RP
Sbjct: 575 GVLMWEIFTLGGSPYPGIPV-EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 633

Query: 902 TFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSS--EHLTCCEQGDI 959
           TF+Q+   L         E +Y +L            S  LE+ S S  +  + C  GD 
Sbjct: 634 TFKQLVEDLDRILTLTTNE-EYLDL------------SQPLEQYSPSYPDTRSSCSSGDD 680

Query: 960 AQPLLQPNNYQFC 972
           +     P  Y+ C
Sbjct: 681 SVFSPDPMPYEPC 693


>gi|221316639 fibroblast growth factor receptor 2 isoform 1
           precursor [Homo sapiens]
          Length = 821

 Score =  276 bits (706), Expect = 7e-74
 Identities = 206/673 (30%), Positives = 317/673 (47%), Gaps = 142/673 (21%)

Query: 364 FTLSLPRLKPSEAGRYSFLARNPGGWRALTFEL-TLRYPPEVSVIW--------TFINGS 414
           ++L +  + PS+ G Y+ +  N  G    T+ L  +   P   ++         T + G 
Sbjct: 214 WSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGD 273

Query: 415 GTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDD--PYPEVLSQEPFH----KVTV 468
              +C      QP++ W++   H ++       +   D  PY +VL     +    ++ V
Sbjct: 274 VEFVCKVYSDAQPHIQWIK---HVEKNGS----KYGPDGLPYLKVLKAAGVNTTDKEIEV 326

Query: 469 QSLLTVETLEHNQTYECRAHNSVG---SGSWAFIPISAGAH---THPPDEFLFTPVVVAC 522
             +  V T E    Y C A NS+G     +W  +  + G     T  PD   +  + + C
Sbjct: 327 LYIRNV-TFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPD---YLEIAIYC 382

Query: 523 MSIMALLLLLLLLLLYKYK---QKPKYQ-------------VRWKIIESYEGNS------ 560
           + +  +  +++ ++L + K   +KP +              +R ++  S E +S      
Sbjct: 383 IGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNT 442

Query: 561 -----------------YTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFG 603
                               +   +LP + KWEFPR+ L  GK LG G FG+VV A A G
Sbjct: 443 PLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVG 502

Query: 604 LGKEDA--VLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLV 661
           + K+     + VAVKMLK  A   +   L+SE+++M  +G+H+NI+NLLGACT  GP+ V
Sbjct: 503 IDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYV 562

Query: 662 ITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVD 721
           I EY   G+L  +LR +                 G++Y                      
Sbjct: 563 IVEYASKGNLREYLRARRPP--------------GMEYS--------------------- 587

Query: 722 TYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAA 781
                              D+++     +  +DL+  + Q+A+GM +LAS+ CIHRD+AA
Sbjct: 588 ------------------YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 629

Query: 782 RNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSY 841
           RNVL+T  +V KI DFGLARDI N   Y    N RLPVKWMAPE++FD VYT QSDVWS+
Sbjct: 630 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 689

Query: 842 GILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRP 901
           G+L+WEIF+LG +PYPGI V  + +KL+K+G++M +PA     +Y +M+ CW   P+ RP
Sbjct: 690 GVLMWEIFTLGGSPYPGIPV-EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 748

Query: 902 TFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSS--EHLTCCEQGDI 959
           TF+Q+   L         E +Y +L            S  LE+ S S  +  + C  GD 
Sbjct: 749 TFKQLVEDLDRILTLTTNE-EYLDL------------SQPLEQYSPSYPDTRSSCSSGDD 795

Query: 960 AQPLLQPNNYQFC 972
           +     P  Y+ C
Sbjct: 796 SVFSPDPMPYEPC 808


>gi|222144241 fibroblast growth factor receptor 2 isoform 8
           precursor [Homo sapiens]
          Length = 704

 Score =  275 bits (704), Expect = 1e-73
 Identities = 206/671 (30%), Positives = 315/671 (46%), Gaps = 140/671 (20%)

Query: 364 FTLSLPRLKPSEAGRYSFLARNPGGWRALTFEL-TLRYPPEVSVIW--------TFINGS 414
           ++L +  + PS+ G Y+ +  N  G    T+ L  +   P   ++         T + G 
Sbjct: 99  WSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGD 158

Query: 415 GTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDD--PYPEVLSQEPFH----KVTV 468
              +C      QP++ W++   H ++       +   D  PY +VL     +    ++ V
Sbjct: 159 VEFVCKVYSDAQPHIQWIK---HVEKNGS----KYGPDGLPYLKVLKAAGVNTTDKEIEV 211

Query: 469 QSLLTVETLEHNQTYECRAHNSVG---SGSWAFIPISAGAH---THPPDEFLFTPVVVAC 522
             +  V T E    Y C A NS+G     +W  +  + G     T  PD   +  + + C
Sbjct: 212 LYIRNV-TFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPD---YLEIAIYC 267

Query: 523 MSIMALLLLLLLLLLYKYK---QKPKY-----------------QVRWKIIESYEGNS-- 560
           + +  +  +++ ++L + K   +KP +                 QV  +   S   N+  
Sbjct: 268 IGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPL 327

Query: 561 ---------------YTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLG 605
                             +   +LP + KWEFPR+ L  GK LG G FG+VV A A G+ 
Sbjct: 328 VRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGID 387

Query: 606 KEDA--VLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVIT 663
           K+     + VAVKMLK  A   +   L+SE+++M  +G+H+NI+NLLGACT  GP+ VI 
Sbjct: 388 KDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 447

Query: 664 EYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTY 723
           EY   G+L  +LR +                 G++Y                        
Sbjct: 448 EYASKGNLREYLRARRPP--------------GMEYS----------------------- 470

Query: 724 VEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARN 783
                            D+++     +  +DL+  + Q+A+GM +LAS+ CIHRD+AARN
Sbjct: 471 ----------------YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARN 514

Query: 784 VLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGI 843
           VL+T  +V KI DFGLARDI N   Y    N RLPVKWMAPE++FD VYT QSDVWS+G+
Sbjct: 515 VLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV 574

Query: 844 LLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTF 903
           L+WEIF+LG +PYPGI V  + +KL+K+G++M +PA     +Y +M+ CW   P+ RPTF
Sbjct: 575 LMWEIFTLGGSPYPGIPV-EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTF 633

Query: 904 QQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSS--EHLTCCEQGDIAQ 961
           +Q+   L         E +Y +L            S  LE+ S S  +  + C  GD + 
Sbjct: 634 KQLVEDLDRILTLTTNE-EYLDL------------SQPLEQYSPSYPDTRSSCSSGDDSV 680

Query: 962 PLLQPNNYQFC 972
               P  Y+ C
Sbjct: 681 FSPDPMPYEPC 691


>gi|222144235 fibroblast growth factor receptor 2 isoform 5
           precursor [Homo sapiens]
          Length = 707

 Score =  275 bits (704), Expect = 1e-73
 Identities = 191/605 (31%), Positives = 295/605 (48%), Gaps = 127/605 (20%)

Query: 364 FTLSLPRLKPSEAGRYSFLARNPGGWRALTFEL-TLRYPPEVSVIW--------TFINGS 414
           ++L +  + PS+ G Y+ +  N  G    T+ L  +   P   ++         T + G 
Sbjct: 125 WSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGD 184

Query: 415 GTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDD--PYPEVLSQEPFH----KVTV 468
              +C      QP++ W++   H ++       +   D  PY +VL     +    ++ V
Sbjct: 185 VEFVCKVYSDAQPHIQWIK---HVEKNGS----KYGPDGLPYLKVLKAAGVNTTDKEIEV 237

Query: 469 QSLLTVETLEHNQTYECRAHNSVG---SGSWAFIPISAGAH---THPPDEFLFTPVVVAC 522
             +  V T E    Y C A NS+G     +W  +  + G     T  PD   +  + + C
Sbjct: 238 LYIRNV-TFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPD---YLEIAIYC 293

Query: 523 MSIMALLLLLLLLLLYKYK---QKPKYQ-------------VRWKIIESYEGNS------ 560
           + +  +  +++ ++L + K   +KP +              +R ++  S E +S      
Sbjct: 294 IGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNT 353

Query: 561 -----------------YTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFG 603
                               +   +LP + KWEFPR+ L  GK LG G FG+VV A A G
Sbjct: 354 PLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVG 413

Query: 604 LGKEDA--VLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLV 661
           + K+     + VAVKMLK  A   +   L+SE+++M  +G+H+NI+NLLGACT  GP+ V
Sbjct: 414 IDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYV 473

Query: 662 ITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVD 721
           I EY   G+L  +LR +                 G++Y                      
Sbjct: 474 IVEYASKGNLREYLRARRPP--------------GMEYS--------------------- 498

Query: 722 TYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAA 781
                              D+++     +  +DL+  + Q+A+GM +LAS+ CIHRD+AA
Sbjct: 499 ------------------YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 540

Query: 782 RNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSY 841
           RNVL+T  +V KI DFGLARDI N   Y    N RLPVKWMAPE++FD VYT QSDVWS+
Sbjct: 541 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 600

Query: 842 GILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRP 901
           G+L+WEIF+LG +PYPGI V  + +KL+K+G++M +PA     +Y +M+ CW   P+ RP
Sbjct: 601 GVLMWEIFTLGGSPYPGIPV-EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 659

Query: 902 TFQQI 906
           TF+Q+
Sbjct: 660 TFKQL 664


>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
           [Homo sapiens]
          Length = 694

 Score =  274 bits (701), Expect = 3e-73
 Identities = 166/410 (40%), Positives = 224/410 (54%), Gaps = 69/410 (16%)

Query: 548 VRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKE 607
           VR   + S EG +   +   +LP + KWE  R  L  GK LG G FG+VV A A G+ K+
Sbjct: 326 VRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKD 385

Query: 608 DAV--LKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEY 665
            A   + VAVKMLK  A   +   L+SE+++M  +G+H+NI+NLLGACT GGP+ V+ EY
Sbjct: 386 RAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEY 445

Query: 666 CCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVE 725
              G+L  FLR +                 G+DY                          
Sbjct: 446 AAKGNLREFLRARRPP--------------GLDY-------------------------- 465

Query: 726 MRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVL 785
                     SF   D  K     L  +DL+  + QVA+GM +LAS+ CIHRD+AARNVL
Sbjct: 466 ----------SF---DTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVL 512

Query: 786 LTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILL 845
           +T  +V KI DFGLARD+ N   Y    N RLPVKWMAPE++FD VYT QSDVWS+G+LL
Sbjct: 513 VTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLL 572

Query: 846 WEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQ 905
           WEIF+LG +PYPGI V  + +KL+K+G++M +PA    ++Y IM+ CW   P+ RPTF+Q
Sbjct: 573 WEIFTLGGSPYPGIPV-EELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQ 631

Query: 906 IC-------------SFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSEL 942
           +               +L   A  ++      + PSSS SG     + +L
Sbjct: 632 LVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDL 681


>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
           [Homo sapiens]
          Length = 731

 Score =  274 bits (701), Expect = 3e-73
 Identities = 197/601 (32%), Positives = 295/601 (49%), Gaps = 119/601 (19%)

Query: 363 TFTLSLPRLKPSEAGRYSFLARNPGGWRALTFEL-TLRYPPEVSVIWTFINGSGTL---- 417
           T+++ +  + PS+ G Y+ +  N  G    T++L  +   P   ++   +  + T+    
Sbjct: 121 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 180

Query: 418 ----LCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDD--PYPEVLSQEPFH----KVT 467
               +C     PQP++ WL+   H     E    ++  D  PY ++L     +    ++ 
Sbjct: 181 NVEFMCKVYSDPQPHIQWLK---HI----EVNGSKIGPDNLPYVQILKTAGVNTTDKEME 233

Query: 468 VQSLLTVETLEHNQTYECRAHNSVG-SGSWAFIPISAGAHTHPP--DEFLFTPVVVACMS 524
           V  L  V + E    Y C A NS+G S   A++ +       P      L+  +++ C  
Sbjct: 234 VLHLRNV-SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTG 292

Query: 525 IMALLLLLLLLLLYKYKQKPKY--------------------QVRWKIIESYEGNSYTF- 563
              +  ++  +++YK K   K                     QV      S   NS    
Sbjct: 293 AFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLL 352

Query: 564 ----------------IDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKE 607
                           +   +LP + +WE PR+ L  GK LG G FG+VV A A GL K+
Sbjct: 353 VRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKD 412

Query: 608 --DAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEY 665
             + V KVAVKMLKS A   +   L+SE+++M  +G+H+NI+NLLGACT  GP+ VI EY
Sbjct: 413 KPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 472

Query: 666 CCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVE 725
              G+L  +L+ +          PG             LE  Y                 
Sbjct: 473 ASKGNLREYLQARRP--------PG-------------LEYCY----------------- 494

Query: 726 MRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVL 785
                   N S + ++        L  +DL+  + QVA+GM +LASK CIHRD+AARNVL
Sbjct: 495 --------NPSHNPEE-------QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVL 539

Query: 786 LTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILL 845
           +T  +V KI DFGLARDI +   Y    N RLPVKWMAPE++FD +YT QSDVWS+G+LL
Sbjct: 540 VTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLL 599

Query: 846 WEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQ 905
           WEIF+LG +PYPG+ V  + +KL+K+G++M +P+     +Y +M+ CW   P+ RPTF+Q
Sbjct: 600 WEIFTLGGSPYPGVPV-EELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 658

Query: 906 I 906
           +
Sbjct: 659 L 659



 Score = 35.8 bits (81), Expect = 0.20
 Identities = 37/134 (27%), Positives = 56/134 (41%), Gaps = 12/134 (8%)

Query: 265 LDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVM 324
           +D V     GNY+C+  N  G  + +    VVE +      +  L    TV  G N++ M
Sbjct: 126 MDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFM 185

Query: 325 VEAY----PGLQGF-----NWTYLGPFSDHQPEPK-LANATTKDTYRHTFTLSLPRLKPS 374
            + Y    P +Q       N + +GP  D+ P  + L  A    T +    L L  +   
Sbjct: 186 CKVYSDPQPHIQWLKHIEVNGSKIGP--DNLPYVQILKTAGVNTTDKEMEVLHLRNVSFE 243

Query: 375 EAGRYSFLARNPGG 388
           +AG Y+ LA N  G
Sbjct: 244 DAGEYTCLAGNSIG 257



 Score = 30.4 bits (67), Expect = 8.4
 Identities = 15/45 (33%), Positives = 25/45 (55%)

Query: 254 NNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVES 298
           N   +++  L+L  V F+ AG Y+C+A N  G    S +  V+E+
Sbjct: 226 NTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEA 270


>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
           [Homo sapiens]
          Length = 733

 Score =  274 bits (701), Expect = 3e-73
 Identities = 197/601 (32%), Positives = 295/601 (49%), Gaps = 119/601 (19%)

Query: 363 TFTLSLPRLKPSEAGRYSFLARNPGGWRALTFEL-TLRYPPEVSVIWTFINGSGTL---- 417
           T+++ +  + PS+ G Y+ +  N  G    T++L  +   P   ++   +  + T+    
Sbjct: 123 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 182

Query: 418 ----LCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDD--PYPEVLSQEPFH----KVT 467
               +C     PQP++ WL+   H     E    ++  D  PY ++L     +    ++ 
Sbjct: 183 NVEFMCKVYSDPQPHIQWLK---HI----EVNGSKIGPDNLPYVQILKTAGVNTTDKEME 235

Query: 468 VQSLLTVETLEHNQTYECRAHNSVG-SGSWAFIPISAGAHTHPP--DEFLFTPVVVACMS 524
           V  L  V + E    Y C A NS+G S   A++ +       P      L+  +++ C  
Sbjct: 236 VLHLRNV-SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTG 294

Query: 525 IMALLLLLLLLLLYKYKQKPKY--------------------QVRWKIIESYEGNSYTF- 563
              +  ++  +++YK K   K                     QV      S   NS    
Sbjct: 295 AFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLL 354

Query: 564 ----------------IDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKE 607
                           +   +LP + +WE PR+ L  GK LG G FG+VV A A GL K+
Sbjct: 355 VRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKD 414

Query: 608 --DAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEY 665
             + V KVAVKMLKS A   +   L+SE+++M  +G+H+NI+NLLGACT  GP+ VI EY
Sbjct: 415 KPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 474

Query: 666 CCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVE 725
              G+L  +L+ +          PG             LE  Y                 
Sbjct: 475 ASKGNLREYLQARRP--------PG-------------LEYCY----------------- 496

Query: 726 MRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVL 785
                   N S + ++        L  +DL+  + QVA+GM +LASK CIHRD+AARNVL
Sbjct: 497 --------NPSHNPEE-------QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVL 541

Query: 786 LTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILL 845
           +T  +V KI DFGLARDI +   Y    N RLPVKWMAPE++FD +YT QSDVWS+G+LL
Sbjct: 542 VTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLL 601

Query: 846 WEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQ 905
           WEIF+LG +PYPG+ V  + +KL+K+G++M +P+     +Y +M+ CW   P+ RPTF+Q
Sbjct: 602 WEIFTLGGSPYPGVPV-EELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 660

Query: 906 I 906
           +
Sbjct: 661 L 661



 Score = 35.8 bits (81), Expect = 0.20
 Identities = 37/134 (27%), Positives = 56/134 (41%), Gaps = 12/134 (8%)

Query: 265 LDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVM 324
           +D V     GNY+C+  N  G  + +    VVE +      +  L    TV  G N++ M
Sbjct: 128 MDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFM 187

Query: 325 VEAY----PGLQGF-----NWTYLGPFSDHQPEPK-LANATTKDTYRHTFTLSLPRLKPS 374
            + Y    P +Q       N + +GP  D+ P  + L  A    T +    L L  +   
Sbjct: 188 CKVYSDPQPHIQWLKHIEVNGSKIGP--DNLPYVQILKTAGVNTTDKEMEVLHLRNVSFE 245

Query: 375 EAGRYSFLARNPGG 388
           +AG Y+ LA N  G
Sbjct: 246 DAGEYTCLAGNSIG 259



 Score = 30.4 bits (67), Expect = 8.4
 Identities = 15/45 (33%), Positives = 25/45 (55%)

Query: 254 NNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVES 298
           N   +++  L+L  V F+ AG Y+C+A N  G    S +  V+E+
Sbjct: 228 NTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEA 272


>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
           [Homo sapiens]
          Length = 820

 Score =  274 bits (701), Expect = 3e-73
 Identities = 197/601 (32%), Positives = 295/601 (49%), Gaps = 119/601 (19%)

Query: 363 TFTLSLPRLKPSEAGRYSFLARNPGGWRALTFEL-TLRYPPEVSVIWTFINGSGTL---- 417
           T+++ +  + PS+ G Y+ +  N  G    T++L  +   P   ++   +  + T+    
Sbjct: 210 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 269

Query: 418 ----LCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDD--PYPEVLSQEPFH----KVT 467
               +C     PQP++ WL+   H     E    ++  D  PY ++L     +    ++ 
Sbjct: 270 NVEFMCKVYSDPQPHIQWLK---HI----EVNGSKIGPDNLPYVQILKTAGVNTTDKEME 322

Query: 468 VQSLLTVETLEHNQTYECRAHNSVG-SGSWAFIPISAGAHTHPP--DEFLFTPVVVACMS 524
           V  L  V + E    Y C A NS+G S   A++ +       P      L+  +++ C  
Sbjct: 323 VLHLRNV-SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTG 381

Query: 525 IMALLLLLLLLLLYKYKQKPKY--------------------QVRWKIIESYEGNSYTF- 563
              +  ++  +++YK K   K                     QV      S   NS    
Sbjct: 382 AFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLL 441

Query: 564 ----------------IDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKE 607
                           +   +LP + +WE PR+ L  GK LG G FG+VV A A GL K+
Sbjct: 442 VRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKD 501

Query: 608 --DAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEY 665
             + V KVAVKMLKS A   +   L+SE+++M  +G+H+NI+NLLGACT  GP+ VI EY
Sbjct: 502 KPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 561

Query: 666 CCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVE 725
              G+L  +L+ +          PG             LE  Y                 
Sbjct: 562 ASKGNLREYLQARRP--------PG-------------LEYCY----------------- 583

Query: 726 MRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVL 785
                   N S + ++        L  +DL+  + QVA+GM +LASK CIHRD+AARNVL
Sbjct: 584 --------NPSHNPEE-------QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVL 628

Query: 786 LTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILL 845
           +T  +V KI DFGLARDI +   Y    N RLPVKWMAPE++FD +YT QSDVWS+G+LL
Sbjct: 629 VTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLL 688

Query: 846 WEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQ 905
           WEIF+LG +PYPG+ V  + +KL+K+G++M +P+     +Y +M+ CW   P+ RPTF+Q
Sbjct: 689 WEIFTLGGSPYPGVPV-EELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 747

Query: 906 I 906
           +
Sbjct: 748 L 748



 Score = 35.8 bits (81), Expect = 0.20
 Identities = 37/134 (27%), Positives = 56/134 (41%), Gaps = 12/134 (8%)

Query: 265 LDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVM 324
           +D V     GNY+C+  N  G  + +    VVE +      +  L    TV  G N++ M
Sbjct: 215 MDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFM 274

Query: 325 VEAY----PGLQGF-----NWTYLGPFSDHQPEPK-LANATTKDTYRHTFTLSLPRLKPS 374
            + Y    P +Q       N + +GP  D+ P  + L  A    T +    L L  +   
Sbjct: 275 CKVYSDPQPHIQWLKHIEVNGSKIGP--DNLPYVQILKTAGVNTTDKEMEVLHLRNVSFE 332

Query: 375 EAGRYSFLARNPGG 388
           +AG Y+ LA N  G
Sbjct: 333 DAGEYTCLAGNSIG 346



 Score = 30.4 bits (67), Expect = 8.4
 Identities = 15/45 (33%), Positives = 25/45 (55%)

Query: 254 NNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVES 298
           N   +++  L+L  V F+ AG Y+C+A N  G    S +  V+E+
Sbjct: 315 NTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEA 359


>gi|105990522 fibroblast growth factor receptor 1 isoform 1
           precursor [Homo sapiens]
          Length = 822

 Score =  274 bits (701), Expect = 3e-73
 Identities = 197/601 (32%), Positives = 295/601 (49%), Gaps = 119/601 (19%)

Query: 363 TFTLSLPRLKPSEAGRYSFLARNPGGWRALTFEL-TLRYPPEVSVIWTFINGSGTL---- 417
           T+++ +  + PS+ G Y+ +  N  G    T++L  +   P   ++   +  + T+    
Sbjct: 212 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 271

Query: 418 ----LCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDD--PYPEVLSQEPFH----KVT 467
               +C     PQP++ WL+   H     E    ++  D  PY ++L     +    ++ 
Sbjct: 272 NVEFMCKVYSDPQPHIQWLK---HI----EVNGSKIGPDNLPYVQILKTAGVNTTDKEME 324

Query: 468 VQSLLTVETLEHNQTYECRAHNSVG-SGSWAFIPISAGAHTHPP--DEFLFTPVVVACMS 524
           V  L  V + E    Y C A NS+G S   A++ +       P      L+  +++ C  
Sbjct: 325 VLHLRNV-SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTG 383

Query: 525 IMALLLLLLLLLLYKYKQKPKY--------------------QVRWKIIESYEGNSYTF- 563
              +  ++  +++YK K   K                     QV      S   NS    
Sbjct: 384 AFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLL 443

Query: 564 ----------------IDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKE 607
                           +   +LP + +WE PR+ L  GK LG G FG+VV A A GL K+
Sbjct: 444 VRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKD 503

Query: 608 --DAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEY 665
             + V KVAVKMLKS A   +   L+SE+++M  +G+H+NI+NLLGACT  GP+ VI EY
Sbjct: 504 KPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 563

Query: 666 CCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVE 725
              G+L  +L+ +          PG             LE  Y                 
Sbjct: 564 ASKGNLREYLQARRP--------PG-------------LEYCY----------------- 585

Query: 726 MRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVL 785
                   N S + ++        L  +DL+  + QVA+GM +LASK CIHRD+AARNVL
Sbjct: 586 --------NPSHNPEE-------QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVL 630

Query: 786 LTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILL 845
           +T  +V KI DFGLARDI +   Y    N RLPVKWMAPE++FD +YT QSDVWS+G+LL
Sbjct: 631 VTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLL 690

Query: 846 WEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQ 905
           WEIF+LG +PYPG+ V  + +KL+K+G++M +P+     +Y +M+ CW   P+ RPTF+Q
Sbjct: 691 WEIFTLGGSPYPGVPV-EELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 749

Query: 906 I 906
           +
Sbjct: 750 L 750



 Score = 35.8 bits (81), Expect = 0.20
 Identities = 37/134 (27%), Positives = 56/134 (41%), Gaps = 12/134 (8%)

Query: 265 LDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVM 324
           +D V     GNY+C+  N  G  + +    VVE +      +  L    TV  G N++ M
Sbjct: 217 MDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFM 276

Query: 325 VEAY----PGLQGF-----NWTYLGPFSDHQPEPK-LANATTKDTYRHTFTLSLPRLKPS 374
            + Y    P +Q       N + +GP  D+ P  + L  A    T +    L L  +   
Sbjct: 277 CKVYSDPQPHIQWLKHIEVNGSKIGP--DNLPYVQILKTAGVNTTDKEMEVLHLRNVSFE 334

Query: 375 EAGRYSFLARNPGG 388
           +AG Y+ LA N  G
Sbjct: 335 DAGEYTCLAGNSIG 348



 Score = 30.4 bits (67), Expect = 8.4
 Identities = 15/45 (33%), Positives = 25/45 (55%)

Query: 254 NNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVES 298
           N   +++  L+L  V F+ AG Y+C+A N  G    S +  V+E+
Sbjct: 317 NTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEA 361


>gi|221316638 fibroblast growth factor receptor 2 isoform 2
           precursor [Homo sapiens]
          Length = 822

 Score =  274 bits (700), Expect = 3e-73
 Identities = 202/673 (30%), Positives = 312/673 (46%), Gaps = 141/673 (20%)

Query: 364 FTLSLPRLKPSEAGRYSFLARNPGGWRALTFEL-TLRYPPEVSVIW--------TFINGS 414
           ++L +  + PS+ G Y+ +  N  G    T+ L  +   P   ++         T + G 
Sbjct: 214 WSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGD 273

Query: 415 GTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDD--PYPEVLSQEPFHKVTVQSLL 472
              +C      QP++ W++   H ++       +   D  PY +VL     +    + L 
Sbjct: 274 VEFVCKVYSDAQPHIQWIK---HVEKNGS----KYGPDGLPYLKVLKHSGINSSNAEVLA 326

Query: 473 TVETLEHNQ-TYECRAHNSVGSGS---WAFI------PISAGAHTHPPDEFLFTPVVVAC 522
                E +   Y C+  N +G  +   W  +      P      T  PD   +  + + C
Sbjct: 327 LFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPD---YLEIAIYC 383

Query: 523 MSIMALLLLLLLLLLYKYK---QKPKYQ-------------VRWKIIESYEGNS------ 560
           + +  +  +++ ++L + K   +KP +              +R ++  S E +S      
Sbjct: 384 IGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNT 443

Query: 561 -----------------YTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFG 603
                               +   +LP + KWEFPR+ L  GK LG G FG+VV A A G
Sbjct: 444 PLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVG 503

Query: 604 LGKEDA--VLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLV 661
           + K+     + VAVKMLK  A   +   L+SE+++M  +G+H+NI+NLLGACT  GP+ V
Sbjct: 504 IDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYV 563

Query: 662 ITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVD 721
           I EY   G+L  +LR +                 G++Y                      
Sbjct: 564 IVEYASKGNLREYLRARRPP--------------GMEYS--------------------- 588

Query: 722 TYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAA 781
                              D+++     +  +DL+  + Q+A+GM +LAS+ CIHRD+AA
Sbjct: 589 ------------------YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 630

Query: 782 RNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSY 841
           RNVL+T  +V KI DFGLARDI N   Y    N RLPVKWMAPE++FD VYT QSDVWS+
Sbjct: 631 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 690

Query: 842 GILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRP 901
           G+L+WEIF+LG +PYPGI V  + +KL+K+G++M +PA     +Y +M+ CW   P+ RP
Sbjct: 691 GVLMWEIFTLGGSPYPGIPV-EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 749

Query: 902 TFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSS--EHLTCCEQGDI 959
           TF+Q+   L         E +Y +L            S  LE+ S S  +  + C  GD 
Sbjct: 750 TFKQLVEDLDRILTLTTNE-EYLDL------------SQPLEQYSPSYPDTRSSCSSGDD 796

Query: 960 AQPLLQPNNYQFC 972
           +     P  Y+ C
Sbjct: 797 SVFSPDPMPYEPC 809


>gi|222144244 fibroblast growth factor receptor 2 isoform 9
           precursor [Homo sapiens]
          Length = 680

 Score =  273 bits (698), Expect = 6e-73
 Identities = 187/605 (30%), Positives = 290/605 (47%), Gaps = 126/605 (20%)

Query: 364 FTLSLPRLKPSEAGRYSFLARNPGGWRALTFEL-TLRYPPEVSVIW--------TFINGS 414
           ++L +  + PS+ G Y+ +  N  G    T+ L  +   P   ++         T + G 
Sbjct: 125 WSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGD 184

Query: 415 GTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDD--PYPEVLSQEPFHKVTVQSLL 472
              +C      QP++ W++   H ++       +   D  PY +VL     +    + L 
Sbjct: 185 VEFVCKVYSDAQPHIQWIK---HVEKNGS----KYGPDGLPYLKVLKHSGINSSNAEVLA 237

Query: 473 TVETLEHNQ-TYECRAHNSVGSGS---WAFI------PISAGAHTHPPDEFLFTPVVVAC 522
                E +   Y C+  N +G  +   W  +      P      T  PD   +  + + C
Sbjct: 238 LFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPD---YLEIAIYC 294

Query: 523 MSIMALLLLLLLLLLYKYK---QKPKYQ-------------VRWKIIESYEGNS------ 560
           + +  +  +++ ++L + K   +KP +              +R ++  S E +S      
Sbjct: 295 IGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNT 354

Query: 561 -----------------YTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFG 603
                               +   +LP + KWEFPR+ L  GK LG G FG+VV A A G
Sbjct: 355 PLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVG 414

Query: 604 LGKEDA--VLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLV 661
           + K+     + VAVKMLK  A   +   L+SE+++M  +G+H+NI+NLLGACT  GP+ V
Sbjct: 415 IDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYV 474

Query: 662 ITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVD 721
           I EY   G+L  +LR +                 G++Y                      
Sbjct: 475 IVEYASKGNLREYLRARRPP--------------GMEYS--------------------- 499

Query: 722 TYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAA 781
                              D+++     +  +DL+  + Q+A+GM +LAS+ CIHRD+AA
Sbjct: 500 ------------------YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 541

Query: 782 RNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSY 841
           RNVL+T  +V KI DFGLARDI N   Y    N RLPVKWMAPE++FD VYT QSDVWS+
Sbjct: 542 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 601

Query: 842 GILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRP 901
           G+L+WEIF+LG +PYPGI V  + +KL+K+G++M +PA     +Y +M+ CW   P+ RP
Sbjct: 602 GVLMWEIFTLGGSPYPGIPV-EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 660

Query: 902 TFQQI 906
           TF+Q+
Sbjct: 661 TFKQL 665


>gi|222144231 fibroblast growth factor receptor 2 isoform 3
           precursor [Homo sapiens]
          Length = 769

 Score =  273 bits (698), Expect = 6e-73
 Identities = 187/605 (30%), Positives = 290/605 (47%), Gaps = 126/605 (20%)

Query: 364 FTLSLPRLKPSEAGRYSFLARNPGGWRALTFEL-TLRYPPEVSVIW--------TFINGS 414
           ++L +  + PS+ G Y+ +  N  G    T+ L  +   P   ++         T + G 
Sbjct: 214 WSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGD 273

Query: 415 GTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDD--PYPEVLSQEPFHKVTVQSLL 472
              +C      QP++ W++   H ++       +   D  PY +VL     +    + L 
Sbjct: 274 VEFVCKVYSDAQPHIQWIK---HVEKNGS----KYGPDGLPYLKVLKHSGINSSNAEVLA 326

Query: 473 TVETLEHNQ-TYECRAHNSVGSGS---WAFI------PISAGAHTHPPDEFLFTPVVVAC 522
                E +   Y C+  N +G  +   W  +      P      T  PD   +  + + C
Sbjct: 327 LFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPD---YLEIAIYC 383

Query: 523 MSIMALLLLLLLLLLYKYK---QKPKYQ-------------VRWKIIESYEGNS------ 560
           + +  +  +++ ++L + K   +KP +              +R ++  S E +S      
Sbjct: 384 IGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNT 443

Query: 561 -----------------YTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFG 603
                               +   +LP + KWEFPR+ L  GK LG G FG+VV A A G
Sbjct: 444 PLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVG 503

Query: 604 LGKEDA--VLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLV 661
           + K+     + VAVKMLK  A   +   L+SE+++M  +G+H+NI+NLLGACT  GP+ V
Sbjct: 504 IDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYV 563

Query: 662 ITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVD 721
           I EY   G+L  +LR +                 G++Y                      
Sbjct: 564 IVEYASKGNLREYLRARRPP--------------GMEYS--------------------- 588

Query: 722 TYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAA 781
                              D+++     +  +DL+  + Q+A+GM +LAS+ CIHRD+AA
Sbjct: 589 ------------------YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 630

Query: 782 RNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSY 841
           RNVL+T  +V KI DFGLARDI N   Y    N RLPVKWMAPE++FD VYT QSDVWS+
Sbjct: 631 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 690

Query: 842 GILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRP 901
           G+L+WEIF+LG +PYPGI V  + +KL+K+G++M +PA     +Y +M+ CW   P+ RP
Sbjct: 691 GVLMWEIFTLGGSPYPGIPV-EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 749

Query: 902 TFQQI 906
           TF+Q+
Sbjct: 750 TFKQL 754


>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
           [Homo sapiens]
          Length = 762

 Score =  273 bits (697), Expect = 7e-73
 Identities = 204/609 (33%), Positives = 285/609 (46%), Gaps = 89/609 (14%)

Query: 364 FTLSLPRLKPSEAGRYSFLARNPGGWRALTFEL-TLRYPPEVSVIWTFINGSGT------ 416
           ++L +  + PS+ G Y+ L  N  G     + L  L   P   ++   +  + T      
Sbjct: 207 WSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSD 266

Query: 417 --LLCAASGYPQPNVTWLQ---CSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSL 471
             LLC      QP++ WL+    +G +   D          PY +VL     +   V+ L
Sbjct: 267 VELLCKVYSDAQPHIQWLKHIVINGSSFGADGF--------PYVQVLKTADINSSEVEVL 318

Query: 472 -LTVETLEHNQTYECRAHNSVG---SGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMA 527
            L   + E    Y C A NS+G     +W  +    G   H   + L TP          
Sbjct: 319 YLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPGTGRIPHLTCDSL-TPA-----GRTK 372

Query: 528 LLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKT 587
              L   L      +     VR   + S        +    LP +  WEFPR+ L  GK 
Sbjct: 373 SPTLQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKP 432

Query: 588 LGAGAFGKVVEATAFGL--GKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHEN 645
           LG G FG+VV A AFG+   + D    VAVKMLK  A   +   L+SE+++M  +G+H+N
Sbjct: 433 LGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKN 492

Query: 646 IVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLE 705
           I+NLLG CT  GP+ VI E    G+L  FLR +     GP LSP                
Sbjct: 493 IINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPP--GPDLSP---------------- 534

Query: 706 KKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQG 765
                 D   SS+G                             PL    L+  + QVA+G
Sbjct: 535 ------DGPRSSEG-----------------------------PLSFPVLVSCAYQVARG 559

Query: 766 MAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPE 825
           M +L S+ CIHRD+AARNVL+T  +V KI DFGLAR + +   Y    N RLPVKWMAPE
Sbjct: 560 MQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPE 619

Query: 826 SIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNI 885
           ++FD VYT QSDVWS+GILLWEIF+LG +PYPGI V  + + L+++G++M +P   P  +
Sbjct: 620 ALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPV-EELFSLLREGHRMDRPPHCPPEL 678

Query: 886 YSIMQACWALEPTHRPTFQQICSFLQE---QAQEDRRERDYTNLPSSSRSGGSGSSSSEL 942
           Y +M+ CW   P+ RPTF+Q+   L +      E+  +   T  P S   G + S+ S  
Sbjct: 679 YGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSS 738

Query: 943 EEESSSEHL 951
           +   S + L
Sbjct: 739 DSVFSHDPL 747


>gi|222144239 fibroblast growth factor receptor 2 isoform 7
           precursor [Homo sapiens]
          Length = 705

 Score =  267 bits (683), Expect = 3e-71
 Identities = 160/409 (39%), Positives = 223/409 (54%), Gaps = 71/409 (17%)

Query: 568 QLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDA--VLKVAVKMLKSTAHAD 625
           +LP + KWEFPR+ L  GK LG G FG+VV A A G+ K+     + VAVKMLK  A   
Sbjct: 351 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 410

Query: 626 EKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGP 685
           +   L+SE+++M  +G+H+NI+NLLGACT  GP+ VI EY   G+L  +LR +       
Sbjct: 411 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPP---- 466

Query: 686 SLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKE 745
                     G++Y                                         D+++ 
Sbjct: 467 ----------GMEYS---------------------------------------YDINRV 477

Query: 746 DGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMN 805
               +  +DL+  + Q+A+GM +LAS+ CIHRD+AARNVL+T  +V KI DFGLARDI N
Sbjct: 478 PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINN 537

Query: 806 DSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKF 865
              Y    N RLPVKWMAPE++FD VYT QSDVWS+G+L+WEIF+LG +PYPGI V  + 
Sbjct: 538 IDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV-EEL 596

Query: 866 YKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTN 925
           +KL+K+G++M +PA     +Y +M+ CW   P+ RPTF+Q+   L         E +Y +
Sbjct: 597 FKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE-EYLD 655

Query: 926 LPSSSRSGGSGSSSSELEEESSS--EHLTCCEQGDIAQPLLQPNNYQFC 972
           L            S  LE+ S S  +  + C  GD +     P  Y+ C
Sbjct: 656 L------------SQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPC 692


>gi|222144233 fibroblast growth factor receptor 2 isoform 4
           precursor [Homo sapiens]
          Length = 709

 Score =  267 bits (683), Expect = 3e-71
 Identities = 160/409 (39%), Positives = 223/409 (54%), Gaps = 71/409 (17%)

Query: 568 QLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDA--VLKVAVKMLKSTAHAD 625
           +LP + KWEFPR+ L  GK LG G FG+VV A A G+ K+     + VAVKMLK  A   
Sbjct: 355 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 414

Query: 626 EKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGP 685
           +   L+SE+++M  +G+H+NI+NLLGACT  GP+ VI EY   G+L  +LR +       
Sbjct: 415 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPP---- 470

Query: 686 SLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKE 745
                     G++Y                                         D+++ 
Sbjct: 471 ----------GMEYS---------------------------------------YDINRV 481

Query: 746 DGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMN 805
               +  +DL+  + Q+A+GM +LAS+ CIHRD+AARNVL+T  +V KI DFGLARDI N
Sbjct: 482 PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINN 541

Query: 806 DSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKF 865
              Y    N RLPVKWMAPE++FD VYT QSDVWS+G+L+WEIF+LG +PYPGI V  + 
Sbjct: 542 IDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV-EEL 600

Query: 866 YKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTN 925
           +KL+K+G++M +PA     +Y +M+ CW   P+ RPTF+Q+   L         E +Y +
Sbjct: 601 FKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE-EYLD 659

Query: 926 LPSSSRSGGSGSSSSELEEESSS--EHLTCCEQGDIAQPLLQPNNYQFC 972
           L            S  LE+ S S  +  + C  GD +     P  Y+ C
Sbjct: 660 L------------SQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPC 696


>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
          Length = 1072

 Score =  265 bits (676), Expect = 2e-70
 Identities = 149/383 (38%), Positives = 205/383 (53%), Gaps = 50/383 (13%)

Query: 564  IDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAH 623
            +D  ++  + KWEFPR NL  GKTLG G FGKVV+ATAF L        VAVKMLK  A 
Sbjct: 706  VDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENAS 765

Query: 624  ADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAML 683
              E   L+SE  ++  +  H +++ L GAC+  GP+L+I EY  YG L  FLR   +   
Sbjct: 766  PSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK--- 821

Query: 684  GPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLD 743
               + PG    GG                                       S +   LD
Sbjct: 822  ---VGPGYLGSGG---------------------------------------SRNSSSLD 839

Query: 744  KEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI 803
              D R L + DL+ F+ Q++QGM +LA    +HRD+AARN+L+  G   KI DFGL+RD+
Sbjct: 840  HPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV 899

Query: 804  MNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNS 863
              + +Y+ +   R+PVKWMA ES+FD +YT QSDVWS+G+LLWEI +LG NPYPGI    
Sbjct: 900  YEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI-PPE 958

Query: 864  KFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDY 923
            + + L+K G++M +P    + +Y +M  CW  EP  RP F  I   L++      + RDY
Sbjct: 959  RLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMV---KRRDY 1015

Query: 924  TNLPSSSRSGGSGSSSSELEEES 946
             +L +S+ S          EEE+
Sbjct: 1016 LDLAASTPSDSLIYDDGLSEEET 1038


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.414 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,472,925
Number of Sequences: 37866
Number of extensions: 1956509
Number of successful extensions: 10174
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 541
Number of HSP's successfully gapped in prelim test: 361
Number of HSP's that attempted gapping in prelim test: 6290
Number of HSP's gapped (non-prelim): 2839
length of query: 972
length of database: 18,247,518
effective HSP length: 112
effective length of query: 860
effective length of database: 14,006,526
effective search space: 12045612360
effective search space used: 12045612360
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.