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Search of human proteins with 26051258
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo
sapiens]
(673 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens] 1400 0.0
gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo sapi... 1360 0.0
gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo sapi... 1315 0.0
gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo sapi... 758 0.0
gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo sapi... 650 0.0
gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo sapi... 649 0.0
gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo sapi... 573 e-163
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 564 e-160
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 506 e-143
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 485 e-137
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 485 e-137
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 481 e-136
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens] 464 e-130
gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens] 464 e-130
gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens] 464 e-130
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 86 1e-16
gi|4758532 ral guanine nucleotide dissociation stimulator-like 2... 81 3e-15
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 79 1e-14
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom... 79 1e-14
gi|15529996 son of sevenless homolog 1 [Homo sapiens] 78 2e-14
gi|40255197 RasGEF domain family, member 1C [Homo sapiens] 76 1e-13
gi|239582765 ral guanine nucleotide dissociation stimulator-like... 74 3e-13
gi|239582763 ral guanine nucleotide dissociation stimulator-like... 74 3e-13
gi|22749129 RasGEF domain family, member 1B [Homo sapiens] 72 2e-12
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 71 4e-12
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 71 4e-12
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa... 71 4e-12
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa... 70 5e-12
gi|110611226 UNC13 (C. elegans)-like [Homo sapiens] 70 6e-12
gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1 [... 70 8e-12
>gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]
Length = 673
Score = 1400 bits (3624), Expect = 0.0
Identities = 673/673 (100%), Positives = 673/673 (100%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
Query: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
Sbjct: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
Query: 301 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS 360
AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS
Sbjct: 301 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS 360
Query: 361 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED 420
LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED
Sbjct: 361 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED 420
Query: 421 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP 480
EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP
Sbjct: 421 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP 480
Query: 481 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL 540
EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL
Sbjct: 481 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL 540
Query: 541 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA 600
HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA
Sbjct: 541 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA 600
Query: 601 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV 660
GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV
Sbjct: 601 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV 660
Query: 661 MDPPSTASSKLDS 673
MDPPSTASSKLDS
Sbjct: 661 MDPPSTASSKLDS 673
>gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo
sapiens]
Length = 659
Score = 1360 bits (3521), Expect = 0.0
Identities = 659/673 (97%), Positives = 659/673 (97%), Gaps = 14/673 (2%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDL---------- 170
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
PGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
Sbjct: 171 ----PGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 226
Query: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
Sbjct: 227 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 286
Query: 301 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS 360
AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS
Sbjct: 287 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS 346
Query: 361 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED 420
LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED
Sbjct: 347 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED 406
Query: 421 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP 480
EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP
Sbjct: 407 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP 466
Query: 481 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL 540
EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL
Sbjct: 467 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL 526
Query: 541 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA 600
HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA
Sbjct: 527 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA 586
Query: 601 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV 660
GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV
Sbjct: 587 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV 646
Query: 661 MDPPSTASSKLDS 673
MDPPSTASSKLDS
Sbjct: 647 MDPPSTASSKLDS 659
>gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo
sapiens]
Length = 639
Score = 1315 bits (3403), Expect = 0.0
Identities = 639/673 (94%), Positives = 639/673 (94%), Gaps = 34/673 (5%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT------------------- 221
Query: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
VMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
Sbjct: 222 ---------------VMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 266
Query: 301 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS 360
AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS
Sbjct: 267 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS 326
Query: 361 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED 420
LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED
Sbjct: 327 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED 386
Query: 421 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP 480
EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP
Sbjct: 387 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP 446
Query: 481 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL 540
EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL
Sbjct: 447 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL 506
Query: 541 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA 600
HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA
Sbjct: 507 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA 566
Query: 601 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV 660
GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV
Sbjct: 567 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV 626
Query: 661 MDPPSTASSKLDS 673
MDPPSTASSKLDS
Sbjct: 627 MDPPSTASSKLDS 639
>gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo
sapiens]
Length = 576
Score = 758 bits (1957), Expect = 0.0
Identities = 355/355 (100%), Positives = 355/355 (100%)
Query: 319 ALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPK 378
ALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPK
Sbjct: 222 ALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPK 281
Query: 379 LNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLP 438
LNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLP
Sbjct: 282 LNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLP 341
Query: 439 PSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNF 498
PSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNF
Sbjct: 342 PSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNF 401
Query: 499 PFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCS 558
PFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCS
Sbjct: 402 PFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCS 461
Query: 559 GFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCG 618
GFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCG
Sbjct: 462 GFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCG 521
Query: 619 SEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 673
SEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS
Sbjct: 522 SEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 576
Score = 454 bits (1168), Expect = e-127
Identities = 221/221 (100%), Positives = 221/221 (100%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 221
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 221
>gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo
sapiens]
Length = 581
Score = 650 bits (1676), Expect = 0.0
Identities = 326/340 (95%), Positives = 328/340 (96%), Gaps = 2/340 (0%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
Query: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
Sbjct: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
Query: 301 AISRLKDSHAHLSPDSTKALLEL--TELLASHNNYARYRR 338
AISRLKDSHAHLSPDSTK L+L TE +YAR R
Sbjct: 301 AISRLKDSHAHLSPDSTKLSLDLFYTEDEIYELSYAREPR 340
Score = 570 bits (1470), Expect = e-162
Identities = 263/263 (100%), Positives = 263/263 (100%)
Query: 411 LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL 470
LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL
Sbjct: 319 LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL 378
Query: 471 VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA 530
VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA
Sbjct: 379 VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA 438
Query: 531 ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 590
ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC
Sbjct: 439 ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 498
Query: 591 KKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPS 650
KKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPS
Sbjct: 499 KKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPS 558
Query: 651 WETDTVPCPVMDPPSTASSKLDS 673
WETDTVPCPVMDPPSTASSKLDS
Sbjct: 559 WETDTVPCPVMDPPSTASSKLDS 581
>gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo
sapiens]
Length = 604
Score = 649 bits (1674), Expect = 0.0
Identities = 320/323 (99%), Positives = 321/323 (99%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
Query: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
Sbjct: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
Query: 301 AISRLKDSHAHLSPDSTKALLEL 323
AISRLKDSHAHLSPDSTK L+ L
Sbjct: 301 AISRLKDSHAHLSPDSTKELVAL 323
Score = 619 bits (1597), Expect = e-177
Identities = 291/306 (95%), Positives = 293/306 (95%), Gaps = 5/306 (1%)
Query: 368 RLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSY 427
RL D HL + +ELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSY
Sbjct: 304 RLKDSHAHLSPDST-----KELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSY 358
Query: 428 AREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTIS 487
AREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTIS
Sbjct: 359 AREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTIS 418
Query: 488 QEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVT 547
QEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVT
Sbjct: 419 QEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVT 478
Query: 548 FRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPV 607
FRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPV
Sbjct: 479 FRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPV 538
Query: 608 PSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTA 667
PSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTA
Sbjct: 539 PSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTA 598
Query: 668 SSKLDS 673
SSKLDS
Sbjct: 599 SSKLDS 604
>gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo
sapiens]
Length = 484
Score = 573 bits (1477), Expect = e-163
Identities = 264/265 (99%), Positives = 265/265 (100%)
Query: 409 LTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE 468
+TLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE
Sbjct: 220 ITLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE 279
Query: 469 QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA 528
QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA
Sbjct: 280 QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA 339
Query: 529 SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV 588
SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV
Sbjct: 340 SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV 399
Query: 589 ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH 648
ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH
Sbjct: 400 ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH 459
Query: 649 PSWETDTVPCPVMDPPSTASSKLDS 673
PSWETDTVPCPVMDPPSTASSKLDS
Sbjct: 460 PSWETDTVPCPVMDPPSTASSKLDS 484
Score = 454 bits (1168), Expect = e-127
Identities = 221/221 (100%), Positives = 221/221 (100%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 221
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 221
>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
sapiens]
Length = 797
Score = 564 bits (1453), Expect = e-160
Identities = 285/569 (50%), Positives = 388/569 (68%), Gaps = 6/569 (1%)
Query: 34 PSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVL 93
PS I++ ++LG L++G S D+L++ CIQSFD+ G+LC + +L ++L MH V+
Sbjct: 39 PSLAHITQFRMMVSLGHLAKGA-SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVI 97
Query: 94 PSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATV 153
SA+L +++T Y+ A L+IC+ VRYW+ + D L + + F V
Sbjct: 98 SSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELV 157
Query: 154 AREGNSAQRRLGDSSDLLSPGGPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLE 213
+G RL D++ + + KKRKVSLLFDHLE EL++HLTYLE
Sbjct: 158 KAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLE 217
Query: 214 FRSFQAITPQDLRSYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDK 273
F+SF+ I+ D ++Y++ V+ P +E S+ L N +S+WVQ+MVLSRP P RA+V K
Sbjct: 218 FKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIK 277
Query: 274 FIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNY 333
FI VAQ+LHQLQNFNTLMAV GGLCHS+ISRLK++ +H+ + K L E+TELL+S NY
Sbjct: 278 FIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNY 337
Query: 334 ARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQ 393
YRR + C F++P+LGVHLKDL+SL+EA PD L DG++++ KL LY + ELV LQ
Sbjct: 338 DNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQ 397
Query: 394 GQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPG 453
PP AN+DL+HLLTLSLDL+YTEDEIYELSYAREPR ++ P +P P+VV+WA G
Sbjct: 398 EVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASG 457
Query: 454 VTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGR 513
V+PKPD T+ +HV+++V+SVFKNYD + G ISQE+FE+++ +FPF+ + +
Sbjct: 458 VSPKPDPKTISKHVQRMVDSVFKNYDHDQDGYISQEEFEKIAASFPFSFCVM---DKDRE 514
Query: 514 GSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRE 573
G SR+E+T Y +RAS+I SKLGL F H F E T+ KPTFCD+C+GFLWGV KQGYRC++
Sbjct: 515 GLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKD 574
Query: 574 CGLCCHKHCRDQVKVECKKRPGAKGDAGP 602
CG+ CHK C+D V ECKKR AK P
Sbjct: 575 CGMNCHKQCKDLVVFECKKR--AKNPVAP 601
>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
sapiens]
Length = 762
Score = 506 bits (1304), Expect = e-143
Identities = 268/569 (47%), Positives = 359/569 (63%), Gaps = 41/569 (7%)
Query: 34 PSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVL 93
PS I++ ++LG L++G S D+L++ CIQSFD+ G+LC + +L ++L MH V+
Sbjct: 39 PSLAHITQFRMMVSLGHLAKGA-SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVI 97
Query: 94 PSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATV 153
SA+L +++T Y+ A L+IC+ VRYW+ + D L + + F V
Sbjct: 98 SSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELV 157
Query: 154 AREGNSAQRRLGDSSDLLSPGGPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLE 213
+G RL D++ + + KKRKVSLLFDHLE EL++HLTYLE
Sbjct: 158 KAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLE 217
Query: 214 FRSFQAITPQDLRSYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDK 273
F+SF+ I+ D ++Y++ V+ P +E S+ L N +S+WVQ+MVLSRP P RA+V K
Sbjct: 218 FKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIK 277
Query: 274 FIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNY 333
FI VAQ+LHQLQNFNTLMAV GGLCHS+ISRLK++ +H+ + K L E+TELL+S NY
Sbjct: 278 FIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNY 337
Query: 334 ARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQ 393
YRR + C F++P+LGVHLKDL+SL+EA PD L DG++++ KL LY + ELV LQ
Sbjct: 338 DNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQ 397
Query: 394 GQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPG 453
PP AN+DL+HLLTLSLDL+YTEDEIYELSYAREPR
Sbjct: 398 EVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPR--------------------- 436
Query: 454 VTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGR 513
SVFKNYD + G ISQE+FE+++ +FPF+ + +
Sbjct: 437 --------------NHRAPSVFKNYDHDQDGYISQEEFEKIAASFPFSFCVM---DKDRE 479
Query: 514 GSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRE 573
G SR+E+T Y +RAS+I SKLGL F H F E T+ KPTFCD+C+GFLWGV KQGYRC++
Sbjct: 480 GLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKD 539
Query: 574 CGLCCHKHCRDQVKVECKKRPGAKGDAGP 602
CG+ CHK C+D V ECKKR AK P
Sbjct: 540 CGMNCHKQCKDLVVFECKKR--AKNPVAP 566
>gi|213385270 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 485 bits (1248), Expect = e-137
Identities = 256/556 (46%), Positives = 359/556 (64%), Gaps = 12/556 (2%)
Query: 59 DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
DELL CI+ FD G L ++ +VL MH W L S +LA +LL Y+ ATG++ R
Sbjct: 13 DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71
Query: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGP 178
L+IC+ +RYW+++ P + D L + F ++ G L D S + P
Sbjct: 72 LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSI--PSYDWM 129
Query: 179 PLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCP 238
+ KK K LLFDHLE ELA+HLT+LE +SF+ I+ D +SYV+ G + P
Sbjct: 130 RRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNP 189
Query: 239 ALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLC 298
LE S+ L N +S+WVQ+MVLS+P P QRA+V+ KFI+VA++L QL+NFNTLMAV GGL
Sbjct: 190 TLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLS 249
Query: 299 HSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDL 358
HS+ISRLK++H+HLS + TK E+TEL++S+ NY YR+ +A C GF++P+LGVHLKDL
Sbjct: 250 HSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDL 309
Query: 359 VSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYT 418
+++H PD + ++++ K++ L + L ELV+LQ N DL++LLTLSLDL++T
Sbjct: 310 IAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHT 369
Query: 419 EDEIYELSYAREPRCPKSLPPSPF--NAPLV-VEWAPGVTPKPDRVTLGRHVEQLVESVF 475
ED+IY+LS EPR KS P SP N P+V +EWA GV PKPD + +H+ +LVESVF
Sbjct: 370 EDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVF 429
Query: 476 KNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA-SAICSK 534
+NYD + G ISQEDFE ++ NFPF + G S++E+ Y LRA S + K
Sbjct: 430 RNYDHDHDGYISQEDFESIAANFPF-LDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCK 488
Query: 535 LGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRP 594
+G F+H F E+T+ KPTFC+ C+GFLWG+ KQGY+C++CG CHK C+D + + C++
Sbjct: 489 MGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFA 548
Query: 595 GA----KGDAGPPGAP 606
A G PG+P
Sbjct: 549 RAPSLSSGHGSLPGSP 564
>gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 485 bits (1248), Expect = e-137
Identities = 256/556 (46%), Positives = 359/556 (64%), Gaps = 12/556 (2%)
Query: 59 DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
DELL CI+ FD G L ++ +VL MH W L S +LA +LL Y+ ATG++ R
Sbjct: 13 DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71
Query: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGP 178
L+IC+ +RYW+++ P + D L + F ++ G L D S + P
Sbjct: 72 LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSI--PSYDWM 129
Query: 179 PLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCP 238
+ KK K LLFDHLE ELA+HLT+LE +SF+ I+ D +SYV+ G + P
Sbjct: 130 RRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNP 189
Query: 239 ALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLC 298
LE S+ L N +S+WVQ+MVLS+P P QRA+V+ KFI+VA++L QL+NFNTLMAV GGL
Sbjct: 190 TLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLS 249
Query: 299 HSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDL 358
HS+ISRLK++H+HLS + TK E+TEL++S+ NY YR+ +A C GF++P+LGVHLKDL
Sbjct: 250 HSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDL 309
Query: 359 VSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYT 418
+++H PD + ++++ K++ L + L ELV+LQ N DL++LLTLSLDL++T
Sbjct: 310 IAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHT 369
Query: 419 EDEIYELSYAREPRCPKSLPPSPF--NAPLV-VEWAPGVTPKPDRVTLGRHVEQLVESVF 475
ED+IY+LS EPR KS P SP N P+V +EWA GV PKPD + +H+ +LVESVF
Sbjct: 370 EDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVF 429
Query: 476 KNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA-SAICSK 534
+NYD + G ISQEDFE ++ NFPF + G S++E+ Y LRA S + K
Sbjct: 430 RNYDHDHDGYISQEDFESIAANFPF-LDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCK 488
Query: 535 LGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRP 594
+G F+H F E+T+ KPTFC+ C+GFLWG+ KQGY+C++CG CHK C+D + + C++
Sbjct: 489 MGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFA 548
Query: 595 GA----KGDAGPPGAP 606
A G PG+P
Sbjct: 549 RAPSLSSGHGSLPGSP 564
>gi|7662334 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 2 [Homo sapiens]
Length = 689
Score = 481 bits (1238), Expect = e-136
Identities = 256/556 (46%), Positives = 359/556 (64%), Gaps = 13/556 (2%)
Query: 59 DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
DELL CI+ FD G L ++ +VL MH W L S +LA +LL Y+ ATG++ R
Sbjct: 13 DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71
Query: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGP 178
L+IC+ +RYW+++ P + D L + F ++ G L D S + P
Sbjct: 72 LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSI--PSYDWM 129
Query: 179 PLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCP 238
+ KK K LLFDHLE ELA+HLT+LE +SF+ I+ D +SYV+ G + P
Sbjct: 130 RRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNP 189
Query: 239 ALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLC 298
LE S+ L N +S+WVQ+MVLS+P P QRA+V+ KFI+VA++L QL+NFNTLMAV GGL
Sbjct: 190 TLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLS 249
Query: 299 HSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDL 358
HS+ISRLK++H+HLS + TK E+TEL++S+ NY YR+ +A C GF++P+LGVHLKDL
Sbjct: 250 HSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDL 309
Query: 359 VSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYT 418
+++H PD + ++++ K++ L + L ELV+LQ N DL++LLTLSLDL++T
Sbjct: 310 IAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHT 369
Query: 419 EDEIYELSYAREPRCPKSLPPSPF--NAPLV-VEWAPGVTPKPDRVTLGRHVEQLVESVF 475
ED+IY+LS EPR KS P SP N P+V +EWA GV PKPD + +H+ +LVESVF
Sbjct: 370 EDDIYKLSLVLEPRNSKS-PTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVF 428
Query: 476 KNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA-SAICSK 534
+NYD + G ISQEDFE ++ NFPF + G S++E+ Y LRA S + K
Sbjct: 429 RNYDHDHDGYISQEDFESIAANFPF-LDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCK 487
Query: 535 LGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRP 594
+G F+H F E+T+ KPTFC+ C+GFLWG+ KQGY+C++CG CHK C+D + + C++
Sbjct: 488 MGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFA 547
Query: 595 GA----KGDAGPPGAP 606
A G PG+P
Sbjct: 548 RAPSLSSGHGSLPGSP 563
>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 464 bits (1193), Expect = e-130
Identities = 252/562 (44%), Positives = 343/562 (61%), Gaps = 13/562 (2%)
Query: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D
Sbjct: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68
Query: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174
+++ CHLVRYW+ P +P+L E I A + +EGN L D D +
Sbjct: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDI-DSVPTY 127
Query: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSV 234
+ +P KKRK+SLLFDHLE ELA+HLTYLE+RSF I QD S+V G
Sbjct: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCT 187
Query: 235 RGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVT 294
P LE + L NSVS+WVQ+M+LS+P QRA V+ F+HVA++L QLQNFNTLMAV
Sbjct: 188 VDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVV 247
Query: 295 GGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVH 354
GGL HS+ISRLK++H+H+SP++ K LTEL+ + NY YRR A C GFR P+LGVH
Sbjct: 248 GGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVH 307
Query: 355 LKDLVSLHEAQPDRLPDGRLHL--PKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLS 412
LKDLV+L A PD L R L K+ L+ L+EL + PP AN DLL LLT+S
Sbjct: 308 LKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVS 367
Query: 413 LDLFYTEDEIYELSYAREPRCPKSLPPSPFNA------PLVVEWAPGVTPKPDRVTLGRH 466
LD + TEDE+Y+LS REPR KS P SP + P++ EW PK D+ + H
Sbjct: 368 LDQYQTEDELYQLSLQREPR-SKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVVEH 426
Query: 467 VEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLL 526
+E++VESVF+N+D +G G ISQE+F+ + GNFP+ + G SREE+ Y L
Sbjct: 427 IEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPY-LSAFGDLDQNQDGCISREEMVSYFL 485
Query: 527 RASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQV 586
R+S++ + F+H F E +P C C + G+ KQG +CR CG+ CHK C+D++
Sbjct: 486 RSSSVLGG-RMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRL 544
Query: 587 KVECKKRPGAKGDAGPPGAPVP 608
VEC++R + G +P P
Sbjct: 545 SVECRRRAQSVSLEGSAPSPSP 566
>gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 464 bits (1193), Expect = e-130
Identities = 252/562 (44%), Positives = 343/562 (61%), Gaps = 13/562 (2%)
Query: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D
Sbjct: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68
Query: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174
+++ CHLVRYW+ P +P+L E I A + +EGN L D D +
Sbjct: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDI-DSVPTY 127
Query: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSV 234
+ +P KKRK+SLLFDHLE ELA+HLTYLE+RSF I QD S+V G
Sbjct: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCT 187
Query: 235 RGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVT 294
P LE + L NSVS+WVQ+M+LS+P QRA V+ F+HVA++L QLQNFNTLMAV
Sbjct: 188 VDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVV 247
Query: 295 GGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVH 354
GGL HS+ISRLK++H+H+SP++ K LTEL+ + NY YRR A C GFR P+LGVH
Sbjct: 248 GGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVH 307
Query: 355 LKDLVSLHEAQPDRLPDGRLHL--PKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLS 412
LKDLV+L A PD L R L K+ L+ L+EL + PP AN DLL LLT+S
Sbjct: 308 LKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVS 367
Query: 413 LDLFYTEDEIYELSYAREPRCPKSLPPSPFNA------PLVVEWAPGVTPKPDRVTLGRH 466
LD + TEDE+Y+LS REPR KS P SP + P++ EW PK D+ + H
Sbjct: 368 LDQYQTEDELYQLSLQREPR-SKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVVEH 426
Query: 467 VEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLL 526
+E++VESVF+N+D +G G ISQE+F+ + GNFP+ + G SREE+ Y L
Sbjct: 427 IEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPY-LSAFGDLDQNQDGCISREEMVSYFL 485
Query: 527 RASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQV 586
R+S++ + F+H F E +P C C + G+ KQG +CR CG+ CHK C+D++
Sbjct: 486 RSSSVLGG-RMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRL 544
Query: 587 KVECKKRPGAKGDAGPPGAPVP 608
VEC++R + G +P P
Sbjct: 545 SVECRRRAQSVSLEGSAPSPSP 566
>gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 464 bits (1193), Expect = e-130
Identities = 252/562 (44%), Positives = 343/562 (61%), Gaps = 13/562 (2%)
Query: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D
Sbjct: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68
Query: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174
+++ CHLVRYW+ P +P+L E I A + +EGN L D D +
Sbjct: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDI-DSVPTY 127
Query: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSV 234
+ +P KKRK+SLLFDHLE ELA+HLTYLE+RSF I QD S+V G
Sbjct: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCT 187
Query: 235 RGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVT 294
P LE + L NSVS+WVQ+M+LS+P QRA V+ F+HVA++L QLQNFNTLMAV
Sbjct: 188 VDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVV 247
Query: 295 GGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVH 354
GGL HS+ISRLK++H+H+SP++ K LTEL+ + NY YRR A C GFR P+LGVH
Sbjct: 248 GGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVH 307
Query: 355 LKDLVSLHEAQPDRLPDGRLHL--PKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLS 412
LKDLV+L A PD L R L K+ L+ L+EL + PP AN DLL LLT+S
Sbjct: 308 LKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVS 367
Query: 413 LDLFYTEDEIYELSYAREPRCPKSLPPSPFNA------PLVVEWAPGVTPKPDRVTLGRH 466
LD + TEDE+Y+LS REPR KS P SP + P++ EW PK D+ + H
Sbjct: 368 LDQYQTEDELYQLSLQREPR-SKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVVEH 426
Query: 467 VEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLL 526
+E++VESVF+N+D +G G ISQE+F+ + GNFP+ + G SREE+ Y L
Sbjct: 427 IEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPY-LSAFGDLDQNQDGCISREEMVSYFL 485
Query: 527 RASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQV 586
R+S++ + F+H F E +P C C + G+ KQG +CR CG+ CHK C+D++
Sbjct: 486 RSSSVLGG-RMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRL 544
Query: 587 KVECKKRPGAKGDAGPPGAPVP 608
VEC++R + G +P P
Sbjct: 545 SVECRRRAQSVSLEGSAPSPSP 566
>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
2 [Homo sapiens]
Length = 1237
Score = 85.9 bits (211), Expect = 1e-16
Identities = 66/241 (27%), Positives = 114/241 (47%), Gaps = 5/241 (2%)
Query: 197 FDHLETGELAQHLTYLEFRSFQAITPQDL--RSYVLQGSVRGCPALEGSVGLSNSVSRWV 254
F+ L ELA+ +T L+ F++I ++ + ++ P + + N +S V
Sbjct: 998 FESLSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLV 1057
Query: 255 QVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSP 314
+++ RA ++K++ VA L N+N ++ +T L SAI RLK + A +S
Sbjct: 1058 ASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSK 1117
Query: 315 DSTKALLE-LTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGR 373
TKAL++ L + ++S + R T C +P LG++L DL + E P+ +G
Sbjct: 1118 Q-TKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGL 1176
Query: 374 LHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRC 433
++ K+ + ++E+ Q + L L DL ED +YELS EPR
Sbjct: 1177 VNFSKMRMISHIIREIRQFQQTSYRIDHQPKVAQYL-LDKDLIIDEDTLYELSLKIEPRL 1235
Query: 434 P 434
P
Sbjct: 1236 P 1236
>gi|4758532 ral guanine nucleotide dissociation stimulator-like 2
[Homo sapiens]
Length = 777
Score = 81.3 bits (199), Expect = 3e-15
Identities = 86/318 (27%), Positives = 135/318 (42%), Gaps = 57/318 (17%)
Query: 128 WLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGD-SSDLL-------SPGGPGPP 179
WL HPE + + + + R + + + G +A + +G S+DL+ P P P
Sbjct: 166 WLASHPEDFGSEAKGQ--LDRLESFLLQTGYAAGKGVGGGSADLIRNLRSRVDPQAPDLP 223
Query: 180 LPMSSPGLGKKRKVSLLF---DHLETGELAQHLTYLEFRSFQAITPQDLRSYVL-----Q 231
P++ PG +L DHL A+ LT L+ F + P +
Sbjct: 224 KPLALPGDPPADPTDVLVFLADHL-----AEQLTLLDAELFLNLIPSQCLGGLWGHRDRP 278
Query: 232 GSVRGCPALEGSVGLSNSVSRWVQVMVLSR------PG--------PLQRAQVLDKFIHV 277
G CP++ +V N V+ V VL PG P QRA++L+K+I V
Sbjct: 279 GHSHLCPSVRATVTQFNKVAGAVVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRV 338
Query: 278 AQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYR 337
A+ L+NF+++ AV L S I RL+ + + DS + L ++ + +NY++ R
Sbjct: 339 AEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSR 398
Query: 338 RTW----------------AGCAGFR----LPVLGVHLKDLVSLHEAQPDRLPDGRLHLP 377
A +G R +P LG LKDLV L A D L +G ++
Sbjct: 399 ELLVQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDAASKDELENGYINFD 458
Query: 378 KLNNLYLRLQELVALQGQ 395
K + L EL LQ +
Sbjct: 459 KRRKEFAVLSELRRLQNE 476
>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
sapiens]
Length = 1095
Score = 79.0 bits (193), Expect = 1e-14
Identities = 58/229 (25%), Positives = 109/229 (47%), Gaps = 7/229 (3%)
Query: 204 ELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPG 263
E+A+ LT L+ F I ++ + + + P L N++S WV+ +++ +
Sbjct: 861 EIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEK 920
Query: 264 PLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLEL 323
R ++L KFI + + L +L NFN+ +A+ L + I RL+ +++ L E
Sbjct: 921 AQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE-----WQKQTSEGLAEY 975
Query: 324 TELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLY 383
L+ S +++ YR + +P LG+ L+DL +H PD + DG+++ K +
Sbjct: 976 CTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYI-DGKVNFSKRWQQF 1034
Query: 384 LRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPR 432
L + Q H N+D+++ D E+ ++ELS +PR
Sbjct: 1035 NILDSMRCFQQAHYDMRRNDDIINFFNDFSD-HLAEEALWELSLKIKPR 1082
>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
sapiens]
Length = 1077
Score = 79.0 bits (193), Expect = 1e-14
Identities = 58/229 (25%), Positives = 109/229 (47%), Gaps = 7/229 (3%)
Query: 204 ELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPG 263
E+A+ LT L+ F I ++ + + + P L N++S WV+ +++ +
Sbjct: 843 EIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEK 902
Query: 264 PLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLEL 323
R ++L KFI + + L +L NFN+ +A+ L + I RL+ +++ L E
Sbjct: 903 AQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE-----WQKQTSEGLAEY 957
Query: 324 TELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLY 383
L+ S +++ YR + +P LG+ L+DL +H PD + DG+++ K +
Sbjct: 958 CTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYI-DGKVNFSKRWQQF 1016
Query: 384 LRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPR 432
L + Q H N+D+++ D E+ ++ELS +PR
Sbjct: 1017 NILDSMRCFQQAHYDMRRNDDIINFFNDFSD-HLAEEALWELSLKIKPR 1064
>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
Length = 1333
Score = 78.2 bits (191), Expect = 2e-14
Identities = 112/486 (23%), Positives = 193/486 (39%), Gaps = 65/486 (13%)
Query: 74 SLCHEDHMLNMVLAMHSWVLPSADLAARL------------LTSYQKATGDTQELRRLQI 121
S C +L++++ P A R+ L ++K +LR L +
Sbjct: 633 SFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNV 692
Query: 122 CHLVRYWLMRHPEVMHQDPQL----EEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPG 177
C R+W+ H +D L EE IG ++ + ++ + GPG
Sbjct: 693 C---RHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPG 749
Query: 178 PPLPMSSPGLGKKRKVSLLFDHLETG--------ELAQHLTYLEFRSFQAITPQDLRSYV 229
+ S + +S H+ET E+A+ LT LE ++A+ P +L V
Sbjct: 750 HNITFQSSPPTVEWHISRP-GHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSV 808
Query: 230 LQGSVR--GCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNF 287
+ P L + + +++ W + ++ +R V+ + I + Q +L NF
Sbjct: 809 WTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNF 868
Query: 288 NTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFR 347
N ++ V + S + RL + + K L E EL S ++Y +Y
Sbjct: 869 NGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHEL--SEDHYKKYLAKLRSINPPC 926
Query: 348 LPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQ------ELVALQGQHPPCSA 401
+P G++L +++ E P+ L + H +L N R + E+ Q Q P C
Sbjct: 927 VPFFGIYLTNILKTEEGNPEVL---KRHGKELINFSKRRKVAEITGEIQQYQNQ-PYCLR 982
Query: 402 NE-------DLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLP--PSPFNAPLVVEWAP 452
E + L+ + S++ +T D ++ S EPR PK LP P ++ PL +P
Sbjct: 983 VESDIKRFFENLNPMGNSMEKEFT-DYLFNKSLEIEPRNPKPLPRFPKKYSYPLK---SP 1038
Query: 453 GVTPKPDRVTLGRH---VEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPP 509
GV P R RH ++Q + + PE S+ + + N P L PPP
Sbjct: 1039 GVRPSNPRPGTMRHPTPLQQEPRKISYSRIPE-----SETESTASAPNSPRT--PLTPPP 1091
Query: 510 RQGRGS 515
G S
Sbjct: 1092 ASGASS 1097
>gi|40255197 RasGEF domain family, member 1C [Homo sapiens]
Length = 466
Score = 75.9 bits (185), Expect = 1e-13
Identities = 67/246 (27%), Positives = 111/246 (45%), Gaps = 25/246 (10%)
Query: 205 LAQHLTYLEFRSFQAITPQD-LRSYVLQ---GSVRGCPA-----LEGSVGLSNSVSRWVQ 255
LAQ LT++E + I P++ ++++V + S + C + LE V N + V
Sbjct: 204 LAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTSNLEAYVKWFNRLCYLVA 263
Query: 256 VMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPD 315
+ QRAQV++ FI VA+ + NFN+LMA+ G+ S +SRLK + A +
Sbjct: 264 TEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKV--- 320
Query: 316 STKALLELTELLASHNNYARYRRTWAGCAGFRL-----------PVLGVHLKDLVSLHEA 364
T L + N+ YR G A L P + +KD+ L+E
Sbjct: 321 RTAKFFILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREKIVIPFFSLLIKDIYFLNEG 380
Query: 365 QPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYE 424
+RLP+G ++ K L ++ E + + P + + H L + ++ED +Y
Sbjct: 381 CANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDASITHYLYTA--PIFSEDGLYL 438
Query: 425 LSYARE 430
SY E
Sbjct: 439 ASYESE 444
>gi|239582765 ral guanine nucleotide dissociation stimulator-like 3
isoform 1 [Homo sapiens]
Length = 716
Score = 74.3 bits (181), Expect = 3e-13
Identities = 71/263 (26%), Positives = 110/263 (41%), Gaps = 30/263 (11%)
Query: 204 ELAQHLTYLEFRSFQAITPQDLRSYVLQ-----GSVRGCPALEGSVGLSNSVSRWVQVMV 258
E+A+ LT ++ F + + V G+ P + +V N+V+ V V
Sbjct: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309
Query: 259 LSRPGPL--QRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDS 316
L PG QRAQ L+K+I +AQR +L+NF++L A+ L + I RLK S +S +
Sbjct: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369
Query: 317 TKALLELTELLASHNNYARYRRTW---AGCAGFR-----------------LPVLGVHLK 356
+L+++ + NN+ R G + +P LG L
Sbjct: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLT 429
Query: 357 DLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLF 416
DLV L A PD L ++ K + L + LQ + + + L L
Sbjct: 430 DLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQ 489
Query: 417 YTEDEIYELSYAREP---RCPKS 436
TE++ Y LS EP CP S
Sbjct: 490 LTEEQSYRLSRVIEPPAASCPSS 512
>gi|239582763 ral guanine nucleotide dissociation stimulator-like 3
isoform 2 [Homo sapiens]
Length = 710
Score = 74.3 bits (181), Expect = 3e-13
Identities = 71/263 (26%), Positives = 110/263 (41%), Gaps = 30/263 (11%)
Query: 204 ELAQHLTYLEFRSFQAITPQDLRSYVLQ-----GSVRGCPALEGSVGLSNSVSRWVQVMV 258
E+A+ LT ++ F + + V G+ P + +V N+V+ V V
Sbjct: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309
Query: 259 LSRPGPL--QRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDS 316
L PG QRAQ L+K+I +AQR +L+NF++L A+ L + I RLK S +S +
Sbjct: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369
Query: 317 TKALLELTELLASHNNYARYRRTW---AGCAGFR-----------------LPVLGVHLK 356
+L+++ + NN+ R G + +P LG L
Sbjct: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLT 429
Query: 357 DLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLF 416
DLV L A PD L ++ K + L + LQ + + + L L
Sbjct: 430 DLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQ 489
Query: 417 YTEDEIYELSYAREP---RCPKS 436
TE++ Y LS EP CP S
Sbjct: 490 LTEEQSYRLSRVIEPPAASCPSS 512
>gi|22749129 RasGEF domain family, member 1B [Homo sapiens]
Length = 473
Score = 71.6 bits (174), Expect = 2e-12
Identities = 66/249 (26%), Positives = 111/249 (44%), Gaps = 29/249 (11%)
Query: 205 LAQHLTYLEFRSFQAITPQDLRSYVLQ----GSVRGCPA-------LEGSVGLSNSVSRW 253
LAQ LT++E I P++ +Q + + C + LE V N +S
Sbjct: 209 LAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYL 268
Query: 254 VQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLS 313
V + RA++++ FI VA+ + NFN+LMA+ G+ S +SRLK + A +
Sbjct: 269 VATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKV- 327
Query: 314 PDSTKALLELTELLASHNNYARYRRTWAGCAGFRL-----------PVLGVHLKDLVSLH 362
T L + +N+ YR G A L P + +KD+ L+
Sbjct: 328 --KTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLN 385
Query: 363 EAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLL-HLLTLSLDLFYTEDE 421
E +RLP+G ++ K L ++ E + + P + +L +LLT+ + ++ED
Sbjct: 386 EGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQYLLTVPV---FSEDA 442
Query: 422 IYELSYARE 430
+Y SY E
Sbjct: 443 LYLASYESE 451
>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 3 [Homo sapiens]
Length = 1257
Score = 70.9 bits (172), Expect = 4e-12
Identities = 57/241 (23%), Positives = 107/241 (44%), Gaps = 5/241 (2%)
Query: 197 FDHLETGELAQHLTYLEFRSFQAITPQDL--RSYVLQGSVRGCPALEGSVGLSNSVSRWV 254
F++ E+A+ LT L+ F+ I ++ + ++ P + + N +S +
Sbjct: 1018 FENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLI 1077
Query: 255 QVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSP 314
++ R ++K++ VA L N+N ++ +T + SAI RLK + +S
Sbjct: 1078 ASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSK 1137
Query: 315 DSTKALLE-LTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGR 373
TKAL++ L +L++S + R C +P LG++L DL + E P+ DG
Sbjct: 1138 Q-TKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGL 1196
Query: 374 LHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRC 433
++ K+ + ++E+ Q + L L E+ +YE S EP+
Sbjct: 1197 VNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL-LDQSFVMDEESLYESSLRIEPKL 1255
Query: 434 P 434
P
Sbjct: 1256 P 1256
>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 1 [Homo sapiens]
Length = 1273
Score = 70.9 bits (172), Expect = 4e-12
Identities = 57/241 (23%), Positives = 107/241 (44%), Gaps = 5/241 (2%)
Query: 197 FDHLETGELAQHLTYLEFRSFQAITPQDL--RSYVLQGSVRGCPALEGSVGLSNSVSRWV 254
F++ E+A+ LT L+ F+ I ++ + ++ P + + N +S +
Sbjct: 1034 FENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLI 1093
Query: 255 QVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSP 314
++ R ++K++ VA L N+N ++ +T + SAI RLK + +S
Sbjct: 1094 ASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSK 1153
Query: 315 DSTKALLE-LTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGR 373
TKAL++ L +L++S + R C +P LG++L DL + E P+ DG
Sbjct: 1154 Q-TKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGL 1212
Query: 374 LHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRC 433
++ K+ + ++E+ Q + L L E+ +YE S EP+
Sbjct: 1213 VNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL-LDQSFVMDEESLYESSLRIEPKL 1271
Query: 434 P 434
P
Sbjct: 1272 P 1272
>gi|24797101 Ras protein-specific guanine nucleotide-releasing
factor 1 isoform 2 [Homo sapiens]
Length = 489
Score = 70.9 bits (172), Expect = 4e-12
Identities = 57/241 (23%), Positives = 107/241 (44%), Gaps = 5/241 (2%)
Query: 197 FDHLETGELAQHLTYLEFRSFQAITPQDL--RSYVLQGSVRGCPALEGSVGLSNSVSRWV 254
F++ E+A+ LT L+ F+ I ++ + ++ P + + N +S +
Sbjct: 250 FENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLI 309
Query: 255 QVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSP 314
++ R ++K++ VA L N+N ++ +T + SAI RLK + +S
Sbjct: 310 ASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSK 369
Query: 315 DSTKALLE-LTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGR 373
TKAL++ L +L++S + R C +P LG++L DL + E P+ DG
Sbjct: 370 Q-TKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGL 428
Query: 374 LHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRC 433
++ K+ + ++E+ Q + L L E+ +YE S EP+
Sbjct: 429 VNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL-LDQSFVMDEESLYESSLRIEPKL 487
Query: 434 P 434
P
Sbjct: 488 P 488
>gi|54633319 PDZ domain-containing guanine nucleotide exchange factor
I [Homo sapiens]
Length = 1601
Score = 70.5 bits (171), Expect = 5e-12
Identities = 53/209 (25%), Positives = 104/209 (49%), Gaps = 6/209 (2%)
Query: 187 LGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQ-GSVRGCPALEGSVG 245
L K+ ++S+L L T E+A L+ +F F+ I P + + + S G L+
Sbjct: 848 LVKESQLSML--QLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHLKRFED 905
Query: 246 LSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRL 305
+ N + WV +L+ L+R +++ FI +A + +NFN++ A+ GL ++++RL
Sbjct: 906 IVNQETFWVASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARL 965
Query: 306 KDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFR--LPVLGVHLKDLVSLHE 363
+ + L K L +L ++ N A+YR + + +P+ V KD+ LHE
Sbjct: 966 RGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHE 1025
Query: 364 AQPDRLPDGRLHLPKLNNLYLRLQELVAL 392
++ DG ++ KL + ++++V +
Sbjct: 1026 GNDSKV-DGLVNFEKLRMISKEIRQVVRM 1053
>gi|110611226 UNC13 (C. elegans)-like [Homo sapiens]
Length = 1591
Score = 70.1 bits (170), Expect = 6e-12
Identities = 31/87 (35%), Positives = 46/87 (52%), Gaps = 2/87 (2%)
Query: 513 RGSFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYR 570
R S EEL ++ + + A+ + H F T PT+C C G LWG+ +QG R
Sbjct: 448 RTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMR 507
Query: 571 CRECGLCCHKHCRDQVKVECKKRPGAK 597
C ECG+ CH+ C+D + +C +R K
Sbjct: 508 CSECGVKCHEKCQDLLNADCLQRAAEK 534
>gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1
[Homo sapiens]
Length = 456
Score = 69.7 bits (169), Expect = 8e-12
Identities = 63/238 (26%), Positives = 106/238 (44%), Gaps = 9/238 (3%)
Query: 200 LETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSV--RGCPALEGSVGLSNSVSRWVQVM 257
+E ++A HLT + F+ + + YV G R LE + + V+ WV
Sbjct: 217 VEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATE 276
Query: 258 VLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDST 317
VL P +RAQ+L KFI +A Q Q+ + AV GL ++A+SRL+ + L
Sbjct: 277 VLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFK 336
Query: 318 KALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLP 377
+ L N+ YR + +P + + LKDL LHE L DG +++
Sbjct: 337 NLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGS-KTLVDGLVNIE 395
Query: 378 KLNNLYLRLQELVALQGQHPPC-----SANEDLLHLLTLSLDLFYTEDEIYELSYARE 430
KL+++ +++ + + + P C S N + ++ ++ELSY E
Sbjct: 396 KLHSVAEKVRTIRKYRSR-PLCLDMEASPNHLQTKAYVRQFQVIDNQNLLFELSYKLE 452
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,151,265
Number of Sequences: 37866
Number of extensions: 1712178
Number of successful extensions: 12343
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 129
Number of HSP's successfully gapped in prelim test: 67
Number of HSP's that attempted gapping in prelim test: 10955
Number of HSP's gapped (non-prelim): 1436
length of query: 673
length of database: 18,247,518
effective HSP length: 109
effective length of query: 564
effective length of database: 14,120,124
effective search space: 7963749936
effective search space used: 7963749936
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.