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Search of human proteins with 24586663
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24586663 adaptor protein, phosphotyrosine interaction, PH
domain and leucine zipper containing 2 [Homo sapiens]
(664 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24586663 adaptor protein, phosphotyrosine interaction, PH dom... 1298 0.0
gi|6912242 adaptor protein, phosphotyrosine interaction, PH doma... 677 0.0
gi|187608516 centaurin, beta 2 [Homo sapiens] 109 9e-24
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma... 104 3e-22
gi|50843948 Rho GTPase activating protein 10 [Homo sapiens] 84 4e-16
gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo s... 83 9e-16
gi|208022687 GTPase regulator associated with the focal adhesion... 79 2e-14
gi|7662208 GTPase regulator associated with the focal adhesion k... 79 2e-14
gi|7661880 centaurin beta1 [Homo sapiens] 71 3e-12
gi|4505507 oligophrenin 1 [Homo sapiens] 66 9e-11
gi|46094081 development and differentiation enhancing factor 1 [... 56 1e-07
gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 55 2e-07
gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain ... 55 2e-07
gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Hom... 47 6e-05
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 42 0.002
gi|62000702 diacylglycerol kinase kappa [Homo sapiens] 42 0.002
gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 41 0.003
gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain... 41 0.003
gi|70166430 GRINL1A combined protein isoform 2 [Homo sapiens] 38 0.026
gi|70166414 GRINL1A combined protein isoform 1 [Homo sapiens] 38 0.026
gi|111494235 GRINL1A combined protein isoform 8 [Homo sapiens] 38 0.026
gi|70166580 GRINL1A upstream protein isoform 7 [Homo sapiens] 38 0.026
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 37 0.045
gi|21361348 UTP14, U3 small nucleolar ribonucleoprotein, homolog... 36 0.13
gi|94721354 methylenetetrahydrofolate dehydrogenase 2 precursor ... 35 0.22
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens] 35 0.22
gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo ... 35 0.29
gi|4885433 mitogen-activated protein kinase 8 interacting protei... 34 0.38
gi|217416392 pleckstrin homology domain containing, family H (wi... 34 0.38
gi|226495417 coiled-coil domain containing 102A [Homo sapiens] 34 0.49
>gi|24586663 adaptor protein, phosphotyrosine interaction, PH domain
and leucine zipper containing 2 [Homo sapiens]
Length = 664
Score = 1298 bits (3360), Expect = 0.0
Identities = 664/664 (100%), Positives = 664/664 (100%)
Query: 1 MPAVDKLLLEEALQDSPQTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQ 60
MPAVDKLLLEEALQDSPQTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQ
Sbjct: 1 MPAVDKLLLEEALQDSPQTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQ 60
Query: 61 LSKQLLAYEKQNFALGKGDEEVISTLHYFSKVVDELNLLHTELAKQLADTMVLPIIQFRE 120
LSKQLLAYEKQNFALGKGDEEVISTLHYFSKVVDELNLLHTELAKQLADTMVLPIIQFRE
Sbjct: 61 LSKQLLAYEKQNFALGKGDEEVISTLHYFSKVVDELNLLHTELAKQLADTMVLPIIQFRE 120
Query: 121 KDLTEVSTLKDLFGLASNEHDLSMAKYSRLPKKKENEKVKTEVGKEVAAARRKQHLSSLQ 180
KDLTEVSTLKDLFGLASNEHDLSMAKYSRLPKKKENEKVKTEVGKEVAAARRKQHLSSLQ
Sbjct: 121 KDLTEVSTLKDLFGLASNEHDLSMAKYSRLPKKKENEKVKTEVGKEVAAARRKQHLSSLQ 180
Query: 181 YYCALNALQYRKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQSIQVEL 240
YYCALNALQYRKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQSIQVEL
Sbjct: 181 YYCALNALQYRKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQSIQVEL 240
Query: 241 EAEAEKMRVSQQELLSVDESVYTPDSDVAAPQINRNLIQKAGYLNLRNKTGLVTTTWERL 300
EAEAEKMRVSQQELLSVDESVYTPDSDVAAPQINRNLIQKAGYLNLRNKTGLVTTTWERL
Sbjct: 241 EAEAEKMRVSQQELLSVDESVYTPDSDVAAPQINRNLIQKAGYLNLRNKTGLVTTTWERL 300
Query: 301 YFFTQGGNLMCQPRGAVAGGLIQDLDNCSVMAVDCEDRRYCFQITTPNGKSGIILQAESR 360
YFFTQGGNLMCQPRGAVAGGLIQDLDNCSVMAVDCEDRRYCFQITTPNGKSGIILQAESR
Sbjct: 301 YFFTQGGNLMCQPRGAVAGGLIQDLDNCSVMAVDCEDRRYCFQITTPNGKSGIILQAESR 360
Query: 361 KENEEWICAINNISRQIYLTDNPEAVAIKLNQTALQAVTPITSFGKKQESSCPSQNLKNS 420
KENEEWICAINNISRQIYLTDNPEAVAIKLNQTALQAVTPITSFGKKQESSCPSQNLKNS
Sbjct: 361 KENEEWICAINNISRQIYLTDNPEAVAIKLNQTALQAVTPITSFGKKQESSCPSQNLKNS 420
Query: 421 EMENENDKIVPKATASLPEAEELIAPGTPIQFDIVLPATEFLDQNRGSRRTNPFGETEDE 480
EMENENDKIVPKATASLPEAEELIAPGTPIQFDIVLPATEFLDQNRGSRRTNPFGETEDE
Sbjct: 421 EMENENDKIVPKATASLPEAEELIAPGTPIQFDIVLPATEFLDQNRGSRRTNPFGETEDE 480
Query: 481 SFPEAEDSLLQQMFIVRFLGSMAVKTDSTTEVIYEAMRQVLAARAIHNIFRMTESHLMVT 540
SFPEAEDSLLQQMFIVRFLGSMAVKTDSTTEVIYEAMRQVLAARAIHNIFRMTESHLMVT
Sbjct: 481 SFPEAEDSLLQQMFIVRFLGSMAVKTDSTTEVIYEAMRQVLAARAIHNIFRMTESHLMVT 540
Query: 541 SQSLRLIDPQTQVSRANFELTSVTQFAAHQENKRLVGFVIRVPESTGEESLSTYIFESNS 600
SQSLRLIDPQTQVSRANFELTSVTQFAAHQENKRLVGFVIRVPESTGEESLSTYIFESNS
Sbjct: 541 SQSLRLIDPQTQVSRANFELTSVTQFAAHQENKRLVGFVIRVPESTGEESLSTYIFESNS 600
Query: 601 EGEKICYAINLGKEIIEVQKDPEALAQLMLSIPLTNDGKYVLLNDQPDDDDGNPNEHRGA 660
EGEKICYAINLGKEIIEVQKDPEALAQLMLSIPLTNDGKYVLLNDQPDDDDGNPNEHRGA
Sbjct: 601 EGEKICYAINLGKEIIEVQKDPEALAQLMLSIPLTNDGKYVLLNDQPDDDDGNPNEHRGA 660
Query: 661 ESEA 664
ESEA
Sbjct: 661 ESEA 664
>gi|6912242 adaptor protein, phosphotyrosine interaction, PH domain
and leucine zipper containing 1 [Homo sapiens]
Length = 709
Score = 677 bits (1748), Expect = 0.0
Identities = 342/627 (54%), Positives = 459/627 (73%), Gaps = 14/627 (2%)
Query: 1 MPAVDKLLLEEALQDSPQTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQ 60
MP +DKL +EE L+DSPQTRSLL VFEEDA +++Y NQL QAM R+Y AQNE+ AT
Sbjct: 1 MPGIDKLPIEETLEDSPQTRSLLGVFEEDATAISNYMNQLYQAMHRIYDAQNELSAATHL 60
Query: 61 LSKQLLAYEKQNFALGKGDEEVISTLHYFSKVVDELNLLHTELAKQLADTMVLPIIQFRE 120
SK L YEKQ F LG DE + STL FSKV+DEL+ H L+ QLAD M+ PI QF+E
Sbjct: 61 TSKLLKEYEKQRFPLGGDDEVMSSTLQQFSKVIDELSSCHAVLSTQLADAMMFPITQFKE 120
Query: 121 KDLTEVSTLKDLFGLASNEHDLSMAKYSRLPKKKENEKVKTEVGKEVAAARRKQHLSSLQ 180
+DL E+ TLK++F +ASN+HD ++ +YSRL KK+EN+KVK EV ++V +R+KQH + +
Sbjct: 121 RDLKEILTLKEVFQIASNDHDAAINRYSRLSKKRENDKVKYEVTEDVYTSRKKQHQTMMH 180
Query: 181 YYCALNALQYRKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQSIQVEL 240
Y+CALN LQY+K++A++EP++G+ QI+FFK G+E +++++ FL+++ VQ+++ E+
Sbjct: 181 YFCALNTLQYKKKIALLEPLLGYMQAQISFFKMGSENLNEQLEEFLANIGTSVQNVRREM 240
Query: 241 EAEAEKMRVSQQELLSVDESVYTPDSDVAAPQINRNLIQKAGYLNLRNKTGLVTTTWERL 300
+++ E M+ + ++L + +Y PD D +NRNL +KAGYLN RNKTGLV++TW+R
Sbjct: 241 DSDIETMQQTIEDLEVASDPLYVPDPDPTKFPVNRNLTRKAGYLNARNKTGLVSSTWDRQ 300
Query: 301 YFFTQGGNLMCQPRGAVAGGLIQDLDNCSVMAVDCEDRRYCFQITTPNGKSGIILQAESR 360
++FTQGGNLM Q RG VAGGL D+DNCSVMAVDCEDRRYCFQIT+ +GK ILQAES+
Sbjct: 301 FYFTQGGNLMSQARGDVAGGLAMDIDNCSVMAVDCEDRRYCFQITSFDGKKSSILQAESK 360
Query: 361 KENEEWICAINNISRQIYLTDNPEAVAIKLNQTALQAVTPITSFGKKQESSCPS--QNLK 418
K++EEWIC INNIS+QIYL++NPE A ++NQ+AL+AVTP SF ++ ES P+ Q+
Sbjct: 361 KDHEEWICTINNISKQIYLSENPEETAARVNQSALEAVTPSPSFQQRHESLRPAAGQSRP 420
Query: 419 NSEMENENDKIVPKAT-ASLPEAEELIAPGTPIQFDIVLPATEFLDQ-------NRGSRR 470
+ + + + ++T + + L+AP TPIQFDI+ P E DQ +G RR
Sbjct: 421 PTARTSSSGSLGSESTNLAALSLDSLVAPDTPIQFDIISPVCE--DQPGQAKAFGQGGRR 478
Query: 471 TNPFGETEDESFPEAEDSLLQQMFIVRFLGSMAVKTDSTTEVIYEAMRQVLAARAIHNIF 530
TNPFGE+ + E EDS+L Q+FIVRFLGSM VK+D +V+YE MRQ+LAARAIHNIF
Sbjct: 479 TNPFGESGGSTKSETEDSILHQLFIVRFLGSMEVKSDDHPDVVYETMRQILAARAIHNIF 538
Query: 531 RMTESHLMVTSQSLRLIDPQTQVSRANFELTSVTQFAAHQENKRLVGFVIRVPESTGEES 590
RMTESHL+VT L+LIDPQTQV+R F L V +A HQENKRL GFV+R E +
Sbjct: 539 RMTESHLLVTCDCLKLIDPQTQVTRLTFPLPCVVLYATHQENKRLFGFVLRTSSGRSESN 598
Query: 591 LST--YIFESNSEGEKICYAINLGKEI 615
LS+ YIFESN+EGEKIC ++ L K+I
Sbjct: 599 LSSVCYIFESNNEGEKICDSVGLAKQI 625
>gi|187608516 centaurin, beta 2 [Homo sapiens]
Length = 778
Score = 109 bits (272), Expect = 9e-24
Identities = 95/384 (24%), Positives = 175/384 (45%), Gaps = 28/384 (7%)
Query: 10 EEALQDSPQTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQLLAYE 69
EE L+DSP+ R+ L E D L ++L++ + C+A +Q +
Sbjct: 8 EECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGI---- 63
Query: 70 KQNFALGKGDEEVIST-LHYFSKVVDELNLLHTELAKQLADTMVLPIIQFREKDLTEVST 128
++ A ++ V+ T L FS + E+ HT L Q ++ + F ++DL +
Sbjct: 64 -RDLAQYSSNDAVVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKFKD 122
Query: 129 LKDLFGLASNEHDLSMAKYSRLPKKKENEKVKTEVGKEVAAARRK--QHLSSLQYYCALN 186
K F S E + ++ K +++ + K++E E + A RK +H++ L Y +N
Sbjct: 123 AKKQFEKVSEEKENALVKNAQVQRNKQHE---VEEATNILTATRKCFRHIA-LDYVLQIN 178
Query: 187 ALQYRKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQSIQVELEAEAEK 246
LQ +++ +++ M+ F + + FF +G ++FS+ + ++ + + + V+ E +
Sbjct: 179 VLQSKRRSEILKSMLSFMYAHLAFFHQGYDLFSE-LGPYMKDLGAQLDRLVVDAAKEKRE 237
Query: 247 MR----VSQQELLSVDESVYTPDSDVAAPQINRNLIQKAGYLNLRNKTGLVTTTWERLYF 302
M QQ+ S D+S + D A N I GYL R TW R +F
Sbjct: 238 MEQKHSTIQQKDFSSDDSKLEYNVDAA------NGIVMEGYLFKRASNAF--KTWNRRWF 289
Query: 303 FTQGGNLMCQPR-GAVAGGLIQDLDNCSVMAVDCEDRRYCFQITTPNGKSGIILQAESRK 361
Q L+ Q + +++DL C+V + +RR+CF++ +P +LQA+S K
Sbjct: 290 SIQNNQLVYQKKFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPT--KSCMLQADSEK 347
Query: 362 ENEEWICAINNISRQIYLTDNPEA 385
+ WI A+ Y E+
Sbjct: 348 LRQAWIKAVQTSIATAYREKGDES 371
>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
3 [Homo sapiens]
Length = 834
Score = 104 bits (259), Expect = 3e-22
Identities = 96/417 (23%), Positives = 188/417 (45%), Gaps = 26/417 (6%)
Query: 10 EEALQDSPQTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQLLAYE 69
EE ++DSP+ R+ + E D + ++L++ + A A S+ ++
Sbjct: 6 EECVKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMVEAGK----AYVSTSRLFVSGV 61
Query: 70 KQNFALGKGDEEVISTLHYFSKVVDELNLLHTELAKQLADTMVLPIIQFREKDLTEVSTL 129
+ +GD + L F+ + E+ H L Q ++ + F ++D+ +
Sbjct: 62 RDLSQQCQGDTVISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVRKFKET 121
Query: 130 KDLFGLASNEHDLSMAKYSRLPKKKENEKVKTEVGKEVAAARRKQHLSSLQYYCALNALQ 189
K F + +LS+ + ++ P+ + +E V+ G + +HL+ L Y +N LQ
Sbjct: 122 KKQFDKVREDLELSLVRNAQAPRHRPHE-VEEATGALTLTRKCFRHLA-LDYVLQINVLQ 179
Query: 190 YRKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQSIQVELEAEAEKMR- 248
+K+ +++ M+ F H Q +FF++G + ++D ++ +A + + ++ E +M
Sbjct: 180 AKKKFEILDSMLSFMHAQSSFFQQGYSLL-HQLDPYMKKLAAELDQLVIDSAVEKREMER 238
Query: 249 ----VSQQELL---SVDESVYTPDSDVAAPQINRNLIQKAGYLNLRNKTGLVTTTWERLY 301
+ Q+ LL S DES + DV AP + + GYL R TW R +
Sbjct: 239 KHAAIQQRTLLQDFSYDES--KVEFDVDAP----SGVVMEGYLFKRASNAF--KTWNRRW 290
Query: 302 FFTQGGNLMCQPRGAVA-GGLIQDLDNCSVMAVDCEDRRYCFQITTPNGKSGIILQAESR 360
F Q L+ Q + A ++ DL CSV + +RR+CF++ +P +LQA+S
Sbjct: 291 FSIQNSQLVYQKKLKDALTVVVDDLRLCSVKPCEDIERRFCFEVLSPT--KSCMLQADSE 348
Query: 361 KENEEWICAINNISRQIYLTDNPEAVAIKLNQTALQAVTPITSFGKKQESSCPSQNL 417
K + W+ A+ Y + +L++TA + + I S +E +++
Sbjct: 349 KLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERGVKGESV 405
>gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]
Length = 786
Score = 84.0 bits (206), Expect = 4e-16
Identities = 80/367 (21%), Positives = 162/367 (44%), Gaps = 24/367 (6%)
Query: 15 DSPQTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQLLAYEKQNFA 74
DSP R + E + + +L++ + + A + +A ++ + L ++ +
Sbjct: 14 DSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSVAQRKFAHSLRDFKFEFIG 73
Query: 75 LGKGDEE--VISTLHYFSKVVDELNLLHTELAKQLADTMVLPIIQFREKDLTEVSTLKDL 132
D+E + ++L FS + L +A + +T++ P+ +FR++ L V K
Sbjct: 74 DAVTDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLGAVKEEKKK 133
Query: 133 FGLASNEHDLSMAKYSRLPKKKENEKVKTEVGKEVAAARRKQHLSSLQYYCALNALQYRK 192
F + ++ + K+ L KK++ ++ E +V R+ + SL+Y C L +Q RK
Sbjct: 134 FDKETEKNYSLIDKHLNLSAKKKDSHLQ-EADIQVEQNRQHFYELSLEYVCKLQEIQERK 192
Query: 193 QMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQSIQVELEAEAEKMRVSQQ 252
+ +EPM+ F G F+ +G E+ +K + + + +Q+ + E R +
Sbjct: 193 KFEFVEPMLSFFQGMFTFYHQGHEL-AKDFNHYKMELQINIQNTRNRFEG----TRSEVE 247
Query: 253 ELLSVDESVYTPDSDVAAPQINRNLIQKAGYLNLRNK-TGLVTTTWERLYFFTQGG---- 307
EL+ ++ P A Q GYL ++ K ++W + Y +
Sbjct: 248 ELM--NKIRQNPKDHKRASQFTAE-----GYLYVQEKRPAPFGSSWVKHYCMYRKAAKKF 300
Query: 308 NLM---CQPRGAVAGGLIQDLDNCSVMAVDCEDRRYCFQITTPNGKS-GIILQAESRKEN 363
N++ + G + G + L C+ D DRR+CF I + + +QA S +E
Sbjct: 301 NMIPFEHRSGGKLGDGEVFFLKECTKRHTDSIDRRFCFDIEAADRPGVSLTMQAFSEEER 360
Query: 364 EEWICAI 370
++W+ A+
Sbjct: 361 KQWLEAL 367
>gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo
sapiens]
Length = 874
Score = 82.8 bits (203), Expect = 9e-16
Identities = 75/378 (19%), Positives = 154/378 (40%), Gaps = 26/378 (6%)
Query: 7 LLLEEALQDSPQTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQLL 66
L ++ DSP R L E + + +L++ + GA + +A Q+ S+ L
Sbjct: 6 LEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQ 65
Query: 67 AYEKQNFALGKGDEEV--ISTLHYFSKVVDELNLLHTELAKQLADTMVLPIIQFREKDLT 124
++ + + D+E+ +L F++++ + L + D ++ P+ +FR++ +
Sbjct: 66 DFQFECIGDAETDDEISIAQSLKEFARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQIG 125
Query: 125 EVSTLKDLFGLASNEHDLSMAKYSRLPKKKENEKVKTEVGKEVAAARRKQHLSSLQYYCA 184
K F S ++ + K+ L KK+ ++ E ++ + + +SL+Y
Sbjct: 126 AAKDGKKKFDKESEKYYSILEKHLNLSAKKKESHLQ-EADTQIDREHQNFYEASLEYVFK 184
Query: 185 LNALQYRKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQSIQVELEAEA 244
+ +Q +K+ +EP++ F G F+ +G E+ A Q +Q L+
Sbjct: 185 IQEVQEKKKFEFVEPLLSFLQGLFTFYHEGYEL--------AQEFAPYKQQLQFNLQNTR 236
Query: 245 EKMRVSQQELLSVDESVYTPDSDVAAPQINRNLIQKAGYLNLRNKTGLVTTTWERLYFFT 304
++QE+ + + + + + D P + GYL ++ K L T + +
Sbjct: 237 NNFESTRQEVERLMQRMKSANQDYRPP----SQWTMEGYLYVQEKRPLGFTWIKHYCTYD 292
Query: 305 QGGNLMC-----QPRGAVAGGLIQD------LDNCSVMAVDCEDRRYCFQITTPNGKSGI 353
+G GL+ L +C D D+R+CF I I
Sbjct: 293 KGSKTFTMSVSEMKSSGKMNGLVTSSPEMFKLKSCIRRKTDSIDKRFCFDIEVVERHGII 352
Query: 354 ILQAESRKENEEWICAIN 371
LQA S + W+ A++
Sbjct: 353 TLQAFSEANRKLWLEAMD 370
>gi|208022687 GTPase regulator associated with the focal adhesion
kinase pp125 isoform b [Homo sapiens]
Length = 759
Score = 78.6 bits (192), Expect = 2e-14
Identities = 74/386 (19%), Positives = 165/386 (42%), Gaps = 38/386 (9%)
Query: 1 MPAVDKLLLEEALQDSPQTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQ 60
+PA++ + DSP R L E + + +L++ + + A + A ++
Sbjct: 3 LPALE---FSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRK 59
Query: 61 LSKQLLAYEKQNFALGKGDEE--VISTLHYFSKVVDELNLLHTELAKQLADTMVLPIIQF 118
+ L ++ Q + D+E + +L F+ V+ L + + ++ ++ P+ +F
Sbjct: 60 FADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKF 119
Query: 119 REKDLTEVSTLKDLFGLASNEHDLSMAKYSRLPKKKENEKVKTEVGKEVAAARRKQHLSS 178
R++ + K + + ++ + K+ L KK+ +++ E +V R+ + S
Sbjct: 120 RKEQIGAAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQ-EADSQVDLVRQHFYEVS 178
Query: 179 LQYYCALNALQYRKQMAMMEPMIGFAHGQINFFKKGAEM------FSKRMDSFLSSVADM 232
L+Y + +Q RK +EP++ F G F+ G E+ F ++ + + +
Sbjct: 179 LEYVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNR 238
Query: 233 VQSIQVELEAEAEKMRVSQQELLSVDESVYTPDSDVAAPQINRNLIQKAGYLNLRNKTGL 292
+ + E+E+ +KM+ + E ++ S YT + GYL ++ K
Sbjct: 239 FEGTRSEVESLMKKMKENPLEHKTI--SPYTME----------------GYLYVQEKRHF 280
Query: 293 VTTTWERLY--FFTQGGNLMCQPRGAVAGGLIQD-----LDNCSVMAVDCEDRRYCFQIT 345
T+W + Y + + P +GG + L +C+ D ++R+CF +
Sbjct: 281 -GTSWVKHYCTYQRDSKQITMVPFDQKSGGKGGEDESVILKSCTRRKTDSIEKRFCFDVE 339
Query: 346 TPNGKSGIILQAESRKENEEWICAIN 371
+ I +QA S ++ W+ A++
Sbjct: 340 AVDRPGVITMQALSEEDRRLWMEAMD 365
>gi|7662208 GTPase regulator associated with the focal adhesion
kinase pp125 isoform a [Homo sapiens]
Length = 814
Score = 78.6 bits (192), Expect = 2e-14
Identities = 74/386 (19%), Positives = 165/386 (42%), Gaps = 38/386 (9%)
Query: 1 MPAVDKLLLEEALQDSPQTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQ 60
+PA++ + DSP R L E + + +L++ + + A + A ++
Sbjct: 3 LPALE---FSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRK 59
Query: 61 LSKQLLAYEKQNFALGKGDEE--VISTLHYFSKVVDELNLLHTELAKQLADTMVLPIIQF 118
+ L ++ Q + D+E + +L F+ V+ L + + ++ ++ P+ +F
Sbjct: 60 FADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKF 119
Query: 119 REKDLTEVSTLKDLFGLASNEHDLSMAKYSRLPKKKENEKVKTEVGKEVAAARRKQHLSS 178
R++ + K + + ++ + K+ L KK+ +++ E +V R+ + S
Sbjct: 120 RKEQIGAAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQ-EADSQVDLVRQHFYEVS 178
Query: 179 LQYYCALNALQYRKQMAMMEPMIGFAHGQINFFKKGAEM------FSKRMDSFLSSVADM 232
L+Y + +Q RK +EP++ F G F+ G E+ F ++ + + +
Sbjct: 179 LEYVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNR 238
Query: 233 VQSIQVELEAEAEKMRVSQQELLSVDESVYTPDSDVAAPQINRNLIQKAGYLNLRNKTGL 292
+ + E+E+ +KM+ + E ++ S YT + GYL ++ K
Sbjct: 239 FEGTRSEVESLMKKMKENPLEHKTI--SPYTME----------------GYLYVQEKRHF 280
Query: 293 VTTTWERLY--FFTQGGNLMCQPRGAVAGGLIQD-----LDNCSVMAVDCEDRRYCFQIT 345
T+W + Y + + P +GG + L +C+ D ++R+CF +
Sbjct: 281 -GTSWVKHYCTYQRDSKQITMVPFDQKSGGKGGEDESVILKSCTRRKTDSIEKRFCFDVE 339
Query: 346 TPNGKSGIILQAESRKENEEWICAIN 371
+ I +QA S ++ W+ A++
Sbjct: 340 AVDRPGVITMQALSEEDRRLWMEAMD 365
>gi|7661880 centaurin beta1 [Homo sapiens]
Length = 740
Score = 71.2 bits (173), Expect = 3e-12
Identities = 79/405 (19%), Positives = 165/405 (40%), Gaps = 19/405 (4%)
Query: 6 KLLLEEALQDSPQTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQL 65
KL EE L+DSP+ R+ + + E + L +LL+ + + A++ +
Sbjct: 4 KLDFEECLKDSPRFRASIELVEAEVSELETRLEKLLKLGTGLLESGRHYLAASRAFVVGI 63
Query: 66 LAYEKQNFALGKGDEEVISTLHYFSKVVDELNLLHTELAKQLADTMVLPIIQFREKDLTE 125
+ LG + + L F+ ++ H EL T+ I ++ L
Sbjct: 64 CDLAR----LGPPEPMMAECLEKFTVSLNHKLDSHAELLDATQHTLQQQIQTLVKEGLRG 119
Query: 126 VSTLKDLFGLASNEHDLSMAKYSRLPKKKENEKVKTEVGKEVAAARRKQHLSSLQYYCAL 185
+ F + + ++ + +P+++ E E G + AR +L Y +
Sbjct: 120 FREARRDFWRGAESLEAALTHNAEVPRRRAQEA--EEAGAALRTARAGYRGRALDYALQI 177
Query: 186 NALQYRKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQSIQVELEAEAE 245
N ++ +++ +ME ++ Q F++G E S R+ + + Q Q+ L + E
Sbjct: 178 NVIEDKRKFDIMEFVLRLVEAQATHFQQGHEELS-RLSQYRKELG--AQLHQLVLNSARE 234
Query: 246 KMRVSQQELLSVDESVYTPDSDVAAPQINRNLIQKAGYLNLRNKTGLVTTTWERLYFFTQ 305
K + Q+ +L + + + + + + L+ + +L + TW R +F Q
Sbjct: 235 KRDMEQRHVLLKQKELGGEEPEPSLREGPGGLVMEG---HLFKRASNAFKTWSRRWFTIQ 291
Query: 306 GGNLMCQPR-GAVAGGLIQDLDNCSVMAVDCEDRRYCFQITTPNGKSGIILQAESRKENE 364
L+ Q + ++ DL C+V +RR+CF++ + + +LQA+S + +
Sbjct: 292 SNQLVYQKKYKDPVTVVVDDLRLCTVKLCPDSERRFCFEVVSTS--KSCLLQADSERLLQ 349
Query: 365 EWICAIN----NISRQIYLTDNPEAVAIKLNQTALQAVTPITSFG 405
W+ A+ + Q L D+P A+ + + S G
Sbjct: 350 LWVSAVQSSIASAFSQARLDDSPRGPGQGSGHLAIGSAATLGSGG 394
>gi|4505507 oligophrenin 1 [Homo sapiens]
Length = 802
Score = 66.2 bits (160), Expect = 9e-11
Identities = 80/398 (20%), Positives = 154/398 (38%), Gaps = 35/398 (8%)
Query: 15 DSPQTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQLLAYEKQNFA 74
DSP R L +E++ + +++ + A A Q+ S+ L +++
Sbjct: 14 DSPDFRERLKCYEQELERTNKFIKDVIKDGNALISAMRNYSSAVQKFSQTLQSFQFDFIG 73
Query: 75 LGKGDEEV--ISTLHYFSKVVDELNLLHTELAKQLADTMVLPIIQFREKDLTEVSTLKDL 132
D+E+ + F+++++E+ + +D ++ P+ FR++ + K
Sbjct: 74 DTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPLENFRKEQIGFTKERKKK 133
Query: 133 FGLASNEHDLSMAKYSRLPKKKENEKVKTEVGKEVAAARRKQHLSSLQYYCALNALQYRK 192
F + ++ L KK+ +++ E +V R SSL Y + +Q K
Sbjct: 134 FEKDGERFYSLLDRHLHLSSKKKESQLQ-EADLQVDKERHNFFESSLDYVYQIQEVQESK 192
Query: 193 QMAMMEPMIGFAHGQINFFKKGAEM------FSKRMDSFLSSVADMVQSIQVELEAEAEK 246
+ ++EP++ F H E+ + +++ L + + S + E+E ++
Sbjct: 193 KFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFSSTREEMEELKKR 252
Query: 247 MRVSQQELLSVDESVYTPDSDVAAPQINRNLIQKAGYLNLRNKTGLVTTTWERLYFF--- 303
M+ + Q + P I GYL + K L +W + Y
Sbjct: 253 MKEAPQTCKLPGQ-----------PTIE-------GYLYTQEKWAL-GISWVKYYCQYEK 293
Query: 304 ---TQGGNLMCQPRGAVAGGLIQDLDNCSVMAVDCEDRRYCFQITTPNGKSGIILQAESR 360
T M Q GA G L L C + D+R+CF I T I LQA S
Sbjct: 294 ETKTLTMTPMEQKPGAKQGPLDLTLKYCVRRKTESIDKRFCFDIETNERPGTITLQALSE 353
Query: 361 KENEEWICAINNISRQIYLTDNPEAVAIKLNQTALQAV 398
W+ A++ IY + + ++LN+ + V
Sbjct: 354 ANRRLWMEAMDG-KEPIYHSPITKQQEMELNEVGFKFV 390
>gi|46094081 development and differentiation enhancing factor 1
[Homo sapiens]
Length = 1129
Score = 55.8 bits (133), Expect = 1e-07
Identities = 83/395 (21%), Positives = 160/395 (40%), Gaps = 51/395 (12%)
Query: 23 LSVFEEDAGTLTDYTNQLLQAMQ-RVYGAQNEMCLATQQLSKQLLAYEK----------- 70
+SV E A T DY + + R++ +N + L + L + A +K
Sbjct: 25 ISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKAIYNS 84
Query: 71 --------QNFA----------LGKGDEEVISTLHYFSKVVDELNLLHTELAKQLADTMV 112
+N+A L + + ++ + FS + EL+ L L + L+ ++
Sbjct: 85 GQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVI 144
Query: 113 LPIIQFREKDLTEVS-TLKDLFGLASNEHDLSMAKYSRLPKK--KENEKVKTEV-GKEVA 168
+ + DL V LK F A +++ K + ++ K++ ++TE+ G E+A
Sbjct: 145 FTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIA 204
Query: 169 AARRKQH----LSSLQYYCALNALQYRKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDS 224
K+ L +Y +N ++ +K + +++ +I + H Q NFF+ G + K
Sbjct: 205 EEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQY 264
Query: 225 FLSSVADM--VQSIQVELEAEAEKMRVSQQELLSVD--ESVYTPDSDVAAPQINRNL--- 277
AD+ ++ Q E + + +R + L +D E + + Q+ N
Sbjct: 265 IEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKEDSQSRQGGYSMHQLQGNKEYG 324
Query: 278 IQKAGYLNLRNKTGLVTTTWERLYFFTQGGNLMCQPRGAVAGGLIQDLDNCSVMAVDCED 337
+K GYL L+ G + W+R + G L + +L C V + ED
Sbjct: 325 SEKKGYL-LKKSDG-IRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKP-NAED 381
Query: 338 RRYCFQITTPNGKSGIILQAESRKENEEWICAINN 372
++ F + + N QAE ++ WI + N
Sbjct: 382 KK-SFDLISHN--RTYHFQAEDEQDYVAWISVLTN 413
>gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform b [Homo sapiens]
Length = 961
Score = 55.1 bits (131), Expect = 2e-07
Identities = 81/377 (21%), Positives = 153/377 (40%), Gaps = 36/377 (9%)
Query: 18 QTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQLL-AYEK-QNFAL 75
Q R+ ++ EE D +L M++ A N LA + +Q A EK +
Sbjct: 32 QCRNTVAAIEE----ALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCV 87
Query: 76 GKGDEEVISTLHYFSKVVDELNLLHTELAKQLADTMVLPIIQFREKDLTEVS-TLKDLFG 134
+ D ++ S FS EL L L + + + + P+ + DL V LK F
Sbjct: 88 CRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFD 147
Query: 135 LASNEHDLSMAKYSRLPKKKENEK----VKTEV-GKEVAAARRKQH----LSSLQYYCAL 185
A +++ + K + +KKE+ K ++TE+ G E+A K+ L +Y +
Sbjct: 148 KAWKDYETKITKIEK--EKKEHAKLHGMIRTEISGAEIAEEMEKERRFFQLQMCEYLLKV 205
Query: 186 NALQYRKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQSIQVELEAEAE 245
N ++ +K + +++ +I + H Q NFF+ G K ++S S+ + + +A+ E
Sbjct: 206 NEIKIKKGVDLLQNLIKYFHAQCNFFQDGL----KAVESLKPSIETLSTDLHTIKQAQDE 261
Query: 246 KMR--VSQQELLSVDESVYTPDSDVAAPQINRNLIQKAGYL--------NLRNKTGLVTT 295
+ R + +++L V + +L Q G +L K+ +
Sbjct: 262 ERRQLIQLRDILKSALQVEQKEDSQIRQSTAYSLHQPQGNKEHGTERNGSLYKKSDGIRK 321
Query: 296 TWERLYFFTQGGNLMCQPRGAVAGGLIQDLDNCSVMAVDCEDRRYCFQITTPNGKSGIIL 355
W++ + G L A +L C V + + CF + + +
Sbjct: 322 VWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVKT--NPEEKKCFDLISHD--RTYHF 377
Query: 356 QAESRKENEEWICAINN 372
QAE +E + W+ + N
Sbjct: 378 QAEDEQECQIWMSVLQN 394
>gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform a [Homo sapiens]
Length = 1006
Score = 55.1 bits (131), Expect = 2e-07
Identities = 81/377 (21%), Positives = 153/377 (40%), Gaps = 36/377 (9%)
Query: 18 QTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQLL-AYEK-QNFAL 75
Q R+ ++ EE D +L M++ A N LA + +Q A EK +
Sbjct: 32 QCRNTVAAIEE----ALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCV 87
Query: 76 GKGDEEVISTLHYFSKVVDELNLLHTELAKQLADTMVLPIIQFREKDLTEVS-TLKDLFG 134
+ D ++ S FS EL L L + + + + P+ + DL V LK F
Sbjct: 88 CRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFD 147
Query: 135 LASNEHDLSMAKYSRLPKKKENEK----VKTEV-GKEVAAARRKQH----LSSLQYYCAL 185
A +++ + K + +KKE+ K ++TE+ G E+A K+ L +Y +
Sbjct: 148 KAWKDYETKITKIEK--EKKEHAKLHGMIRTEISGAEIAEEMEKERRFFQLQMCEYLLKV 205
Query: 186 NALQYRKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQSIQVELEAEAE 245
N ++ +K + +++ +I + H Q NFF+ G K ++S S+ + + +A+ E
Sbjct: 206 NEIKIKKGVDLLQNLIKYFHAQCNFFQDGL----KAVESLKPSIETLSTDLHTIKQAQDE 261
Query: 246 KMR--VSQQELLSVDESVYTPDSDVAAPQINRNLIQKAGYL--------NLRNKTGLVTT 295
+ R + +++L V + +L Q G +L K+ +
Sbjct: 262 ERRQLIQLRDILKSALQVEQKEDSQIRQSTAYSLHQPQGNKEHGTERNGSLYKKSDGIRK 321
Query: 296 TWERLYFFTQGGNLMCQPRGAVAGGLIQDLDNCSVMAVDCEDRRYCFQITTPNGKSGIIL 355
W++ + G L A +L C V + + CF + + +
Sbjct: 322 VWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVKT--NPEEKKCFDLISHD--RTYHF 377
Query: 356 QAESRKENEEWICAINN 372
QAE +E + W+ + N
Sbjct: 378 QAEDEQECQIWMSVLQN 394
>gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Homo
sapiens]
Length = 304
Score = 47.0 bits (110), Expect = 6e-05
Identities = 33/140 (23%), Positives = 72/140 (51%), Gaps = 7/140 (5%)
Query: 474 FGETEDESFPEAEDSLLQQM--FIVRFLGSMAVKTDSTTEVIYEAMRQVLAARAIHNI-- 529
F +D+++ ++L + + +FLGS V+ TEV+ +A+R++ AR I
Sbjct: 5 FSRKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEG 64
Query: 530 FRMTESHLMVTSQSLRLIDPQTQVSRANFELTSVTQFAAHQENKRLVGFVIRVPESTGEE 589
++ + L ++ +++++P+T+ + N +L ++ A + +KR+ F+ + ES
Sbjct: 65 QKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESNKH- 123
Query: 590 SLSTYIFESNSEGEKICYAI 609
Y+F+S E+I I
Sbjct: 124 --LCYVFDSEKCAEEITLTI 141
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 42.0 bits (97), Expect = 0.002
Identities = 67/294 (22%), Positives = 120/294 (40%), Gaps = 60/294 (20%)
Query: 10 EEALQDSPQTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQLLAYE 69
E+ALQD Q R L + E A T+ + QL + V + + L K+ A E
Sbjct: 747 EQALQDLQQQRQLNTDLELRA---TELSKQLEMEKEIVSSTRLD-------LQKKSEALE 796
Query: 70 KQNFALGKGDEEVISTLHYFSKVVDELNLLHTELAKQLADTM--VLPIIQFREKDLTEVS 127
L K +EE F + E + H EL ++ T+ + + +E +TE+S
Sbjct: 797 SIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELS 856
Query: 128 TLKDLFGLASNEHDLSMAKYSRLPKKKENEKVKTEV------------------------ 163
T+KD S+ K S+ +KEN+K K +
Sbjct: 857 TVKDKLSKVSDS-----LKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKE 911
Query: 164 GKEVAAARRKQHLSSLQYYCALNALQYR--------KQMAMMEPMIGFAHGQINFFKKGA 215
KE+ + K+ +S Q LN++Q + KQ E + G IN K+ +
Sbjct: 912 QKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQL---QGNINELKQSS 968
Query: 216 EMFSKRMDSFLSSV-------ADMVQSIQVELEAEAEKMRVSQQELLSVDESVY 262
E K++++ + ++ +Q +L A+++ +++E +SV ++ Y
Sbjct: 969 EQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQEL-AAEKEKISVLQNNY 1021
>gi|62000702 diacylglycerol kinase kappa [Homo sapiens]
Length = 1271
Score = 41.6 bits (96), Expect = 0.002
Identities = 29/83 (34%), Positives = 38/83 (45%), Gaps = 3/83 (3%)
Query: 297 WERLYFFTQGGNLMCQPRGAVAGGLIQDLDNCSVMAVDCEDRRYCFQITTPNGKSGIILQ 356
W+ YF QG L A A DL +V C + + F + TP K I L
Sbjct: 233 WKLRYFLVQGQKLYFAHHPAFAHFETIDLSQATVAESSCRNLCHSFCVITPQRK--ITLA 290
Query: 357 AESRKENEEWICAINNISR-QIY 378
A +RK+ EEWI I I + +IY
Sbjct: 291 APNRKDMEEWINIIKTIQQGEIY 313
>gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform b [Homo sapiens]
Length = 894
Score = 41.2 bits (95), Expect = 0.003
Identities = 53/246 (21%), Positives = 100/246 (40%), Gaps = 22/246 (8%)
Query: 142 LSMAKYSRLPKKKENEKVKT----EVGKEVAAARRKQHLSSLQYYCALNALQYRKQMAMM 197
LS+ ++L K+++ +V EV +++ RR L +Y Q ++ +
Sbjct: 144 LSLGSRAKLEKERDRARVTGGIPGEVAQDMQRERRIFQLHMCEYLLKAGESQMKQGPDFL 203
Query: 198 EPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQSIQVELEAEAEKMRVSQQ----- 252
+ +I F H Q NFF+ G + ++ + F+ +A V ++ E E +K+ +
Sbjct: 204 QSLIKFFHAQHNFFQDGWKA-AQSLFPFIEKLAASVHALHQAQEDELQKLTQLRDSLRGT 262
Query: 253 -ELLSVDESVYTPDS----DVAAPQINRNL-IQKAGYLNLRNKTGLVTTTWERLYFFTQG 306
+L S +E + +S + Q N+ +K G+ L K+ + W++ +
Sbjct: 263 LQLESREEHLSRKNSGCGYSIHQHQGNKQFGTEKVGF--LYKKSDGIRRVWQKRKCGVKY 320
Query: 307 GNLMCQPRGAVAGGLIQDLDNCSVMAVDCEDRRYCFQITTPNGKSGIILQAESRKENEEW 366
G L + L C V + + CF + T N QAE E E W
Sbjct: 321 GCLTISHSTINRPPVKLTLLTCQVR--PNPEEKKCFDLVTHN--RTYHFQAEDEHECEAW 376
Query: 367 ICAINN 372
+ + N
Sbjct: 377 VSVLQN 382
>gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform a [Homo sapiens]
Length = 903
Score = 41.2 bits (95), Expect = 0.003
Identities = 53/243 (21%), Positives = 99/243 (40%), Gaps = 22/243 (9%)
Query: 145 AKYSRLPKKKENEKVKT----EVGKEVAAARRKQHLSSLQYYCALNALQYRKQMAMMEPM 200
AK ++L K+++ +V EV +++ RR L +Y Q ++ ++ +
Sbjct: 156 AKMAKLEKERDRARVTGGIPGEVAQDMQRERRIFQLHMCEYLLKAGESQMKQGPDFLQSL 215
Query: 201 IGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQSIQVELEAEAEKMRVSQQ------EL 254
I F H Q NFF+ G + ++ + F+ +A V ++ E E +K+ + +L
Sbjct: 216 IKFFHAQHNFFQDGWKA-AQSLFPFIEKLAASVHALHQAQEDELQKLTQLRDSLRGTLQL 274
Query: 255 LSVDESVYTPDS----DVAAPQINRNL-IQKAGYLNLRNKTGLVTTTWERLYFFTQGGNL 309
S +E + +S + Q N+ +K G+ L K+ + W++ + G L
Sbjct: 275 ESREEHLSRKNSGCGYSIHQHQGNKQFGTEKVGF--LYKKSDGIRRVWQKRKCGVKYGCL 332
Query: 310 MCQPRGAVAGGLIQDLDNCSVMAVDCEDRRYCFQITTPNGKSGIILQAESRKENEEWICA 369
+ L C V + + CF + T N QAE E E W+
Sbjct: 333 TISHSTINRPPVKLTLLTCQVR--PNPEEKKCFDLVTHN--RTYHFQAEDEHECEAWVSV 388
Query: 370 INN 372
+ N
Sbjct: 389 LQN 391
>gi|70166430 GRINL1A combined protein isoform 2 [Homo sapiens]
Length = 445
Score = 38.1 bits (87), Expect = 0.026
Identities = 61/244 (25%), Positives = 103/244 (42%), Gaps = 35/244 (14%)
Query: 24 SVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQLLAYEKQNFALGKGDEEVI 83
S +E+ + D L + +R+YG +EM +QL+++L Q E +
Sbjct: 95 SQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQ-------QEYLE 147
Query: 84 STLHYFSKVVDELNLLHTELAKQ---LADTMVLPIIQFREKDLT-EVSTLKDLFGLASNE 139
+ + S +D N +++ LA L T+V D+T E S +KD
Sbjct: 148 NHIQTQSSALDRFNAMNSALASDSIGLQKTLV---------DVTLENSNIKDQIRNLQQT 198
Query: 140 HDLSMAKYSRLPK-----KKENE--KVKTEVGKEVAAARRKQHLSSL--QYYCALNALQY 190
++ SM K + + EN+ K+K E +E A ++ L QY L Q
Sbjct: 199 YEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQ- 257
Query: 191 RKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQSIQVELEAEAEKMRVS 250
RK A E ++ + N F K E +K+M + S+ + Q I EL+ E+M
Sbjct: 258 RKHSAEKEALL----EETNSFLKAIEEANKKMQAAEISLEEKDQRIG-ELDRLIERMEKE 312
Query: 251 QQEL 254
+ +L
Sbjct: 313 RHQL 316
>gi|70166414 GRINL1A combined protein isoform 1 [Homo sapiens]
Length = 550
Score = 38.1 bits (87), Expect = 0.026
Identities = 61/244 (25%), Positives = 103/244 (42%), Gaps = 35/244 (14%)
Query: 24 SVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQLLAYEKQNFALGKGDEEVI 83
S +E+ + D L + +R+YG +EM +QL+++L Q E +
Sbjct: 95 SQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQ-------QEYLE 147
Query: 84 STLHYFSKVVDELNLLHTELAKQ---LADTMVLPIIQFREKDLT-EVSTLKDLFGLASNE 139
+ + S +D N +++ LA L T+V D+T E S +KD
Sbjct: 148 NHIQTQSSALDRFNAMNSALASDSIGLQKTLV---------DVTLENSNIKDQIRNLQQT 198
Query: 140 HDLSMAKYSRLPK-----KKENE--KVKTEVGKEVAAARRKQHLSSL--QYYCALNALQY 190
++ SM K + + EN+ K+K E +E A ++ L QY L Q
Sbjct: 199 YEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQ- 257
Query: 191 RKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQSIQVELEAEAEKMRVS 250
RK A E ++ + N F K E +K+M + S+ + Q I EL+ E+M
Sbjct: 258 RKHSAEKEALL----EETNSFLKAIEEANKKMQAAEISLEEKDQRIG-ELDRLIERMEKE 312
Query: 251 QQEL 254
+ +L
Sbjct: 313 RHQL 316
>gi|111494235 GRINL1A combined protein isoform 8 [Homo sapiens]
Length = 438
Score = 38.1 bits (87), Expect = 0.026
Identities = 61/244 (25%), Positives = 103/244 (42%), Gaps = 35/244 (14%)
Query: 24 SVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQLLAYEKQNFALGKGDEEVI 83
S +E+ + D L + +R+YG +EM +QL+++L Q E +
Sbjct: 95 SQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQ-------QEYLE 147
Query: 84 STLHYFSKVVDELNLLHTELAKQ---LADTMVLPIIQFREKDLT-EVSTLKDLFGLASNE 139
+ + S +D N +++ LA L T+V D+T E S +KD
Sbjct: 148 NHIQTQSSALDRFNAMNSALASDSIGLQKTLV---------DVTLENSNIKDQIRNLQQT 198
Query: 140 HDLSMAKYSRLPK-----KKENE--KVKTEVGKEVAAARRKQHLSSL--QYYCALNALQY 190
++ SM K + + EN+ K+K E +E A ++ L QY L Q
Sbjct: 199 YEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQ- 257
Query: 191 RKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQSIQVELEAEAEKMRVS 250
RK A E ++ + N F K E +K+M + S+ + Q I EL+ E+M
Sbjct: 258 RKHSAEKEALL----EETNSFLKAIEEANKKMQAAEISLEEKDQRIG-ELDRLIERMEKE 312
Query: 251 QQEL 254
+ +L
Sbjct: 313 RHQL 316
>gi|70166580 GRINL1A upstream protein isoform 7 [Homo sapiens]
Length = 466
Score = 38.1 bits (87), Expect = 0.026
Identities = 61/244 (25%), Positives = 103/244 (42%), Gaps = 35/244 (14%)
Query: 24 SVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQLLAYEKQNFALGKGDEEVI 83
S +E+ + D L + +R+YG +EM +QL+++L Q E +
Sbjct: 95 SQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQ-------QEYLE 147
Query: 84 STLHYFSKVVDELNLLHTELAKQ---LADTMVLPIIQFREKDLT-EVSTLKDLFGLASNE 139
+ + S +D N +++ LA L T+V D+T E S +KD
Sbjct: 148 NHIQTQSSALDRFNAMNSALASDSIGLQKTLV---------DVTLENSNIKDQIRNLQQT 198
Query: 140 HDLSMAKYSRLPK-----KKENE--KVKTEVGKEVAAARRKQHLSSL--QYYCALNALQY 190
++ SM K + + EN+ K+K E +E A ++ L QY L Q
Sbjct: 199 YEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQ- 257
Query: 191 RKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQSIQVELEAEAEKMRVS 250
RK A E ++ + N F K E +K+M + S+ + Q I EL+ E+M
Sbjct: 258 RKHSAEKEALL----EETNSFLKAIEEANKKMQAAEISLEEKDQRIG-ELDRLIERMEKE 312
Query: 251 QQEL 254
+ +L
Sbjct: 313 RHQL 316
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 37.4 bits (85), Expect = 0.045
Identities = 51/257 (19%), Positives = 106/257 (41%), Gaps = 29/257 (11%)
Query: 25 VFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQLLAYEKQNFALGKGDEEVIS 84
V EE+ D TNQL++ ++ + + K + + + + GD + +
Sbjct: 2426 VLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRI-VGDYQQLE 2484
Query: 85 TLHYF----------------SKVVDELNLLHTELAKQLADTMVL--PIIQFREKDLTEV 126
H +K+ +E+ L + + ++ L +IQ+RE DL +V
Sbjct: 2485 ERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYRE-DLNQV 2543
Query: 127 STLKD-----LFGLASNEHDLSMAKYSRLPKK-KENEKVKTEVGKEV-AAARRKQHLSSL 179
T+KD L + ++ KY++L +K KE+E+ ++ + A KQ LS
Sbjct: 2544 ITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKE 2603
Query: 180 QYYCALNALQYRKQMAMM--EPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQSIQ 237
++ Q +Q+ + E +G H Q+ ++ S S +A++ + +
Sbjct: 2604 IESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELV 2663
Query: 238 VELEAEAEKMRVSQQEL 254
+ A+K+ + +L
Sbjct: 2664 CVQKEAAKKVGEIEDKL 2680
>gi|21361348 UTP14, U3 small nucleolar ribonucleoprotein, homolog A
[Homo sapiens]
Length = 771
Score = 35.8 bits (81), Expect = 0.13
Identities = 46/191 (24%), Positives = 74/191 (38%), Gaps = 21/191 (10%)
Query: 79 DEEVISTLHYFSKVVDELNLLHTELAKQLADTMVLPIIQFREKDLTEVSTLKDLF-GLAS 137
++E+ + LH + V + L E A A M L + R +L L+ + A
Sbjct: 185 EQEIFNLLHKNKQPVTDPLLTPVEKASLRA--MSLEEAKMRRAELQRARALQSYYEAKAR 242
Query: 138 NEHDLSMAKYSRLPKKKENEKVKTEVGKEVAAARRKQHLSSLQYYCALNALQYRKQMAMM 197
E + KY ++ KK GK A + + L + AL L+ ++ MM
Sbjct: 243 REKKIKSKKYHKVVKK----------GKAKKALKEFEQLRKVNPAAALEELEKIEKARMM 292
Query: 198 EPMIGFAHGQINFFKKGAEMFSK-------RMDSFLSSVADMVQSIQVELEAEAEKMRVS 250
E M H + K + +K M LS ++ Q +QV E+E E+
Sbjct: 293 ERM-SLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESEEEEGGTE 351
Query: 251 QQELLSVDESV 261
E L V + V
Sbjct: 352 DVEELLVPDVV 362
>gi|94721354 methylenetetrahydrofolate dehydrogenase 2 precursor
[Homo sapiens]
Length = 350
Score = 35.0 bits (79), Expect = 0.22
Identities = 35/138 (25%), Positives = 58/138 (42%), Gaps = 17/138 (12%)
Query: 316 AVAGGLIQDLDNCSVMAVDCEDRRYCFQITTPNGKSGII--------LQAESRKENEEWI 367
A+A L+Q +CS+ R F + ++ +I ++ E R+E EEW+
Sbjct: 9 ALAARLLQPAHSCSL-------RLRPFHLAAVRNEAVVISGRKLAQQIKQEVRQEVEEWV 61
Query: 368 CAINNISRQ--IYLTDNPEAVAIKLNQTALQAVTPITSFGKKQESSCPSQNLKNSEMENE 425
+ N I + +NP + + LN+T AV I S + +S + L N +
Sbjct: 62 ASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKLN 121
Query: 426 NDKIVPKATASLPEAEEL 443
ND V LP E +
Sbjct: 122 NDDNVDGLLVQLPLPEHI 139
>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
Length = 766
Score = 35.0 bits (79), Expect = 0.22
Identities = 31/124 (25%), Positives = 54/124 (43%), Gaps = 21/124 (16%)
Query: 253 ELLSVDESVYTPDSDVAAPQINRNLIQKAGYLNLRNKTGLVTTTWERLYFFTQGGNLMCQ 312
E+L +E + P ++ LI++ L L + T+ ER F L C
Sbjct: 408 EMLGEEEDIVNPSNE---------LIKEGQILKLAARN---TSAQERYLFLFNNMLLYCV 455
Query: 313 PRGAVAGGLIQ-----DLDNCSVMAVDCEDRRYCFQITTPNGKSGII-LQAESRKENEEW 366
P+ ++ G +D ++ E+ + FQ++ GK + LQA S ++ EEW
Sbjct: 456 PKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVS---GKERTLELQASSAQDKEEW 512
Query: 367 ICAI 370
I A+
Sbjct: 513 IKAL 516
>gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo
sapiens]
Length = 1214
Score = 34.7 bits (78), Expect = 0.29
Identities = 30/105 (28%), Positives = 47/105 (44%), Gaps = 5/105 (4%)
Query: 272 QINRNLIQKAGYLNLRNKTGLVTTTWERLYFFTQGGNLMCQPRGAVAGGLIQDLDNCSVM 331
QI + I K G L +N + + +R YF +G L DL + SV
Sbjct: 48 QIRQKTIIKEGMLTKQNNSFQRS---KRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVA 104
Query: 332 AVDCEDRRYCFQITTPNGKSGIILQAESRKENEEWICAINNISRQ 376
++ F + TP K +IL A++RKE E+WI A+ + +
Sbjct: 105 ESSTKNVNNSFTVITPCRK--LILCADNRKEMEDWIAALKTVQNR 147
>gi|4885433 mitogen-activated protein kinase 8 interacting protein 1
[Homo sapiens]
Length = 711
Score = 34.3 bits (77), Expect = 0.38
Identities = 27/133 (20%), Positives = 59/133 (44%), Gaps = 11/133 (8%)
Query: 485 AEDSLLQQMFIVRFLGSMAVKTDSTTEVIYEAMRQVLAARAIHNIFRMTES---HLMVTS 541
A++S F V+FLGS+ V +V+ AM+++ R + F S + V
Sbjct: 558 AKNSDWVDQFRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCVLEISVRG 617
Query: 542 QSLRLIDPQTQVSRAN-----FELTSVTQFAAHQENKRLVGFVIRVPESTGEESLSTYIF 596
+ + +Q ++ N F+L +++ H +N + GF+ + P + + ++F
Sbjct: 618 VKIGVKADDSQEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFITKHP---ADHRFACHVF 674
Query: 597 ESNSEGEKICYAI 609
S + + ++
Sbjct: 675 VSEDSTKALAESV 687
>gi|217416392 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 2 [Homo sapiens]
Length = 1493
Score = 34.3 bits (77), Expect = 0.38
Identities = 30/102 (29%), Positives = 48/102 (47%), Gaps = 12/102 (11%)
Query: 278 IQKAGYLNLRNKTGLVTTTWERLYFFTQGGNLMC--QPRGAV--AGGLIQDLDNCSVMAV 333
++K+GYL K +W+R +F +GG L+ P + G I+ +CS++
Sbjct: 704 LEKSGYLL---KMSGKVKSWKRRWFVLKGGELLYYKSPSDVIRKPQGHIELSASCSILR- 759
Query: 334 DCEDRRYCFQITTPNGKSGIILQAESRKENEEWICAINNISR 375
D + Q+TT K L A+S EEWI + N+ R
Sbjct: 760 --GDNKQTVQLTTE--KHTYYLTADSPNILEEWIKVLQNVLR 797
>gi|226495417 coiled-coil domain containing 102A [Homo sapiens]
Length = 550
Score = 33.9 bits (76), Expect = 0.49
Identities = 52/227 (22%), Positives = 97/227 (42%), Gaps = 48/227 (21%)
Query: 56 LATQQLSKQLLAYEKQNFALGKGDEEVISTLHYFSKVVDELNLLHTELAKQLADTMVLPI 115
L + K LL + AL + E++ L + +EL+ E+ KQL+ +
Sbjct: 257 LRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSI-----L 311
Query: 116 IQFREKDLTEVST-LKDLFGLASN-----------------EHDLSMAKYSRLPKKK--- 154
+ + +L +S L+D G S+ E+ + RL +K
Sbjct: 312 KEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGL 371
Query: 155 --ENEKVKTEVG--KEVAAARRKQHLSSLQYYCALNALQ---YRKQMAMMEPMIGFAHGQ 207
EN+K++ +VG +E A RR+Q S+L C L A Q + K + + + HG+
Sbjct: 372 ERENKKLRAQVGDLEEALARRRRQTASALD--CDLRASQAALFEKNKELAD--LKHVHGK 427
Query: 208 INFFKKGAEMFSKRMDSFLSSVADMVQSIQVELEAEAEKMRVSQQEL 254
+ K+ ++ +A + ++ + EAE +K+R+ +EL
Sbjct: 428 L----------KKQFQEKVAELAHANRRVE-QHEAEVKKLRLRVEEL 463
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.357
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,591,202
Number of Sequences: 37866
Number of extensions: 951218
Number of successful extensions: 3421
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 66
Number of HSP's that attempted gapping in prelim test: 3347
Number of HSP's gapped (non-prelim): 119
length of query: 664
length of database: 18,247,518
effective HSP length: 109
effective length of query: 555
effective length of database: 14,120,124
effective search space: 7836668820
effective search space used: 7836668820
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.