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Search of human proteins with 119120874
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|119120874 formin-like 3 isoform 1 [Homo sapiens]
(1027 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|119120874 formin-like 3 isoform 1 [Homo sapiens] 2038 0.0
gi|119120861 formin-like 3 isoform 2 [Homo sapiens] 1905 0.0
gi|52485606 formin-like 2 [Homo sapiens] 1419 0.0
gi|33356148 formin-like 1 [Homo sapiens] 1092 0.0
gi|40548415 dishevelled associated activator of morphogenesis 2 ... 328 2e-89
gi|21071077 dishevelled-associated activator of morphogenesis 1 ... 295 1e-79
gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens] 285 1e-76
gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens] 263 8e-70
gi|6382071 diaphanous 2 isoform 12C [Homo sapiens] 256 6e-68
gi|5803003 diaphanous 2 isoform 156 [Homo sapiens] 256 6e-68
gi|149999378 inverted formin 2 isoform 2 [Homo sapiens] 206 1e-52
gi|149999380 inverted formin 2 isoform 1 [Homo sapiens] 206 1e-52
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens] 191 2e-48
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens] 191 2e-48
gi|145309324 FH2 domain containing 1 [Homo sapiens] 166 1e-40
gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2) int... 144 4e-34
gi|157168329 formin 1 [Homo sapiens] 138 2e-32
gi|58331242 formin homology 2 domain containing 3 [Homo sapiens] 116 9e-26
gi|160707881 formin 2 [Homo sapiens] 112 1e-24
gi|118572599 formin homology 2 domain containing 1 [Homo sapiens] 107 6e-23
gi|14249316 hypothetical protein LOC84800 [Homo sapiens] 85 3e-16
gi|56549694 enabled homolog isoform a [Homo sapiens] 62 4e-09
gi|39930375 enabled homolog isoform b [Homo sapiens] 62 4e-09
gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Hom... 59 2e-08
gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Hom... 59 2e-08
gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo sap... 59 2e-08
gi|153792074 proline rich 12 [Homo sapiens] 58 5e-08
gi|150170670 piccolo isoform 2 [Homo sapiens] 57 9e-08
gi|150378539 piccolo isoform 1 [Homo sapiens] 57 9e-08
gi|187761324 shootin1 isoform a [Homo sapiens] 57 9e-08
>gi|119120874 formin-like 3 isoform 1 [Homo sapiens]
Length = 1027
Score = 2038 bits (5281), Expect = 0.0
Identities = 1027/1027 (100%), Positives = 1027/1027 (100%)
Query: 1 MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDN 60
MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDN
Sbjct: 1 MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDN 60
Query: 61 EKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTN 120
EKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTN
Sbjct: 61 EKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTN 120
Query: 121 HIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQP 180
HIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQP
Sbjct: 121 HIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQP 180
Query: 181 PSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYG 240
PSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYG
Sbjct: 181 PSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYG 240
Query: 241 FNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKEL 300
FNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKEL
Sbjct: 241 FNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKEL 300
Query: 301 HRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSR 360
HRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSR
Sbjct: 301 HRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSR 360
Query: 361 HTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENM 420
HTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENM
Sbjct: 361 HTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENM 420
Query: 421 MRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLES 480
MRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLES
Sbjct: 421 MRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLES 480
Query: 481 VDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPA 540
VDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPA
Sbjct: 481 VDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPA 540
Query: 541 PPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILED 600
PPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILED
Sbjct: 541 PPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILED 600
Query: 601 LDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEE 660
LDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEE
Sbjct: 601 LDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEE 660
Query: 661 ICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKV 720
ICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKV
Sbjct: 661 ICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKV 720
Query: 721 ERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSS 780
ERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSS
Sbjct: 721 ERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSS 780
Query: 781 KRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS 840
KRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS
Sbjct: 781 KRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS 840
Query: 841 LENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVR 900
LENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVR
Sbjct: 841 LENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVR 900
Query: 901 YFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPS 960
YFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPS
Sbjct: 901 YFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPS 960
Query: 961 QRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITGLHCQPMVVRHQARSAAPPSGP 1020
QRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITGLHCQPMVVRHQARSAAPPSGP
Sbjct: 961 QRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITGLHCQPMVVRHQARSAAPPSGP 1020
Query: 1021 PRAPGPH 1027
PRAPGPH
Sbjct: 1021 PRAPGPH 1027
>gi|119120861 formin-like 3 isoform 2 [Homo sapiens]
Length = 976
Score = 1905 bits (4936), Expect = 0.0
Identities = 972/1027 (94%), Positives = 973/1027 (94%), Gaps = 51/1027 (4%)
Query: 1 MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDN 60
MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDN
Sbjct: 1 MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDN 60
Query: 61 EKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTN 120
EKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTN
Sbjct: 61 EKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTN 120
Query: 121 HIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQP 180
HIGWVREFLNDENKGLDVLVDYLSFA
Sbjct: 121 HIGWVREFLNDENKGLDVLVDYLSFA---------------------------------- 146
Query: 181 PSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYG 240
Q + YSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYG
Sbjct: 147 -----------------QCSVMYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYG 189
Query: 241 FNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKEL 300
FNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKEL
Sbjct: 190 FNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKEL 249
Query: 301 HRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSR 360
HRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSR
Sbjct: 250 HRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSR 309
Query: 361 HTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENM 420
HTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENM
Sbjct: 310 HTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENM 369
Query: 421 MRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLES 480
MRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLES
Sbjct: 370 MRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLES 429
Query: 481 VDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPA 540
VDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPA
Sbjct: 430 VDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPA 489
Query: 541 PPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILED 600
PPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILED
Sbjct: 490 PPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILED 549
Query: 601 LDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEE 660
LDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEE
Sbjct: 550 LDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEE 609
Query: 661 ICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKV 720
ICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKV
Sbjct: 610 ICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKV 669
Query: 721 ERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSS 780
ERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSS
Sbjct: 670 ERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSS 729
Query: 781 KRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS 840
KRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS
Sbjct: 730 KRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS 789
Query: 841 LENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVR 900
LENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVR
Sbjct: 790 LENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVR 849
Query: 901 YFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPS 960
YFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPS
Sbjct: 850 YFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPS 909
Query: 961 QRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITGLHCQPMVVRHQARSAAPPSGP 1020
QRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITGLHCQPMVVRHQARSAAPPSGP
Sbjct: 910 QRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITGLHCQPMVVRHQARSAAPPSGP 969
Query: 1021 PRAPGPH 1027
PRAPGPH
Sbjct: 970 PRAPGPH 976
>gi|52485606 formin-like 2 [Homo sapiens]
Length = 1092
Score = 1419 bits (3674), Expect = 0.0
Identities = 732/1043 (70%), Positives = 857/1043 (82%), Gaps = 61/1043 (5%)
Query: 23 PGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTY 82
P K+PMPEP ELEERFA+VL++MNLPPDKARLLRQYDNEKKW+LICDQERFQVKNPPHTY
Sbjct: 20 PLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELICDQERFQVKNPPHTY 79
Query: 83 IQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDY 142
IQKL+ +LDP+VTRKKFRRRVQEST+VLRELEISLRTNHIGWVREFLN+ENKGLDVLV+Y
Sbjct: 80 IQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEY 139
Query: 143 LSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQPPSALSAPFTNSLARSARQSVLR 202
LSFAQ +V FDFE +ES + + DK + WSRSIEDL S L +P NS++RS R S LR
Sbjct: 140 LSFAQYAVTFDFESVESTVESSVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALR 199
Query: 203 YSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKN 262
Y+TLP RR LKNSRLVS+KDDVHVCI+CLRAIMNYQYGFN+VMSHPHAVNEIALSLNNKN
Sbjct: 200 YNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKN 259
Query: 263 PRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVA 322
PRTKALVLELLAAVCLVRGGHEIIL+AFDNFKEVC E RFEKLME+FRNED+NIDFMVA
Sbjct: 260 PRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVA 319
Query: 323 CMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVG 382
MQFINIVVHSVEDMNFRVHLQYEFTKLGL+E+L K +HTES+KLQVQIQAYLDNVFDVG
Sbjct: 320 SMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVG 379
Query: 383 GLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAELEKQLLQREKELESIKE 442
LLEDAETKN ALE+VEELEE++SHL+EKL D ENE M ++ ELEKQL+QR KEL+ ++E
Sbjct: 380 ALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVRE 439
Query: 443 TYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLE----------------------- 479
Y++ + QVHTLR+++KEKEEA QR+ LE + LE
Sbjct: 440 IYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDIAILPVVAS 499
Query: 480 ---SVDSEALA--RVGP---AELSEGMPPSDLDLLAPAPPPEEVL------PLPPPPAPP 525
S+ SE +A VGP A S +PP L + PE V P+PPPP PP
Sbjct: 500 GTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPP 559
Query: 526 LPPPPPPLPDKCPP--------------------APPLPG-AAPSVVLTVGLSAIRIKKP 564
PPPPPP P PP APPLPG ++P+VV GL+A++IKKP
Sbjct: 560 PPPPPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAPPLPGTSSPTVVFNSGLAAVKIKKP 619
Query: 565 IKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICS 624
IKTKFR+PVFNW ALKPNQI+GTVF+E+DDE+ILEDL++D+FEE+FKTKAQGPA+DL S
Sbjct: 620 IKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSS 679
Query: 625 KNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRF 684
K K QK ++KVTLLEANRAKNLAITLRKAG++A+EIC+AIH FDL+TLPVDFVECLMRF
Sbjct: 680 KQKIPQKGSNKVTLLEANRAKNLAITLRKAGKTADEICKAIHVFDLKTLPVDFVECLMRF 739
Query: 685 LPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLT 744
LPTE EVK+LR YERER+PLE L+ EDRFM+ FSK+ERL Q+M MAF+GNF +++QMLT
Sbjct: 740 LPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLMQKMTIMAFIGNFAESIQMLT 799
Query: 745 PQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDR 804
PQL+AIIAAS S+KSSQKLK++LEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDR
Sbjct: 800 PQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDR 859
Query: 805 KMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSI 864
K TLLH+I+ VKEKY ++ F++ELH+VEKAAAVSLENVLLDVKEL RGM+L +RE ++
Sbjct: 860 KQTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTM 919
Query: 865 HD-NSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIR 923
HD N++L+ F+ NEGKL KLQ DAK A++A++ VV+YFGE+PKTTPPSVFFPVFVRF++
Sbjct: 920 HDHNTLLKEFILNNEGKLKKLQDDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVK 979
Query: 924 SYKEAEQENEARKKQEEVMREKQLAQEA--KKLDAKTPSQRNKWQQQELIAELRRRQAKE 981
+YK+AE+ENE RKKQE+ + EK L QEA ++ D K+PS ++K QQQELIAELRRRQ K+
Sbjct: 980 AYKQAEEENELRKKQEQALMEKLLEQEALMEQQDPKSPSHKSKRQQQELIAELRRRQVKD 1039
Query: 982 HRPVYEGKDGTIEDIITGLHCQP 1004
+R VYEGKDG IEDIIT L QP
Sbjct: 1040 NRHVYEGKDGAIEDIITDLRNQP 1062
>gi|33356148 formin-like 1 [Homo sapiens]
Length = 1100
Score = 1092 bits (2824), Expect = 0.0
Identities = 607/1100 (55%), Positives = 748/1100 (68%), Gaps = 100/1100 (9%)
Query: 1 MGNLESAEGVPGEPPSVPLLLP-PGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYD 59
MGN + P P + P P P K PMP ELEERF L+ MNLPPDK +LL QYD
Sbjct: 1 MGNAAGSAEQPAGPAAPPPKQPAPPKQPMPAAGELEERFNRALNCMNLPPDKVQLLSQYD 60
Query: 60 NEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKK----------FRRRVQESTKV 109
NEKKW+LICDQERFQVKNPP YIQKL+S++D +K F+RRVQEST+V
Sbjct: 61 NEKKWELICDQERFQVKNPPAAYIQKLKSYVDTGGVSRKVAADWMSNLGFKRRVQESTQV 120
Query: 110 LRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLR 169
LRELE SLRTNHIGWV+EFLN+EN+GLDVL++YL+FAQCSV +D E ++G + +K +
Sbjct: 121 LRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVTYDMESTDNGASNS-EKNK 179
Query: 170 SWSRSIEDLQPPSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCIL 229
+S+EDL S P +R ++ + R+AL+NSR+VSQKDDVHVCI+
Sbjct: 180 PLEQSVEDLSKGPPSSVP-------KSRHLTIKLTPAHSRKALRNSRIVSQKDDVHVCIM 232
Query: 230 CLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAA 289
CLRAIMNYQ GF+LVM+HP VNEIALSLNNKNPRTKALVLELLAAVCLVRGGH+IILAA
Sbjct: 233 CLRAIMNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHDIILAA 292
Query: 290 FDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTK 349
FDNFKEVC E HRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVE+MNFRV LQYEFT
Sbjct: 293 FDNFKEVCGEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTH 352
Query: 350 LGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLT 409
LGL+ +L++ R TES+KLQVQIQAYLDN+FDVG LLED ETKN LE +EEL+E V+ LT
Sbjct: 353 LGLDLYLERLRLTESDKLQVQIQAYLDNIFDVGALLEDTETKNAVLEHMEELQEQVALLT 412
Query: 410 EKLLDLENENMMRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEK--EEAFQR 467
E+L D ENE+M ++AELEKQL Q KELE+++E + ++ + R EK A R
Sbjct: 413 ERLRDAENESMAKIAELEKQLSQARKELETLRERFSESTAMGASRRPPEPEKAPPAAPTR 472
Query: 468 RCHLEPNVRGLESVDSEALARV--GPAE-----------------------LSEGMPPSD 502
LE V E ++ + L R+ GP + + G P D
Sbjct: 473 PSALELKV---EELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPD 529
Query: 503 LDLLA--------PAPPPEEVLPLP-------------------PPPAPPLP---PPPP- 531
L A P PPP LP P PPPAPPLP PPPP
Sbjct: 530 LAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPP 589
Query: 532 ----------PLPDKCPPAPPLPGAAPSVV----LTVGLSAIRIKKPIKTKFRLPVFNWT 577
P+P PP PP PG P + +G ++ KKPI+TKFR+P+ NW
Sbjct: 590 PPPPPPGTDGPVPPPPPPPPPPPGGPPDALGRRDSELG-PGVKAKKPIQTKFRMPLLNWV 648
Query: 578 ALKPNQISGTVFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVT 637
ALKP+QI+GTVF+EL+DEK+L++LD+ FEE FKTK+QGP+LDL K+K AQKA SK T
Sbjct: 649 ALKPSQITGTVFTELNDEKVLQELDMSDFEEQFKTKSQGPSLDLSALKSKAAQKAPSKAT 708
Query: 638 LLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQY 697
L+EANRAKNLAITLRK AE IC+AI +DLQ L +DF+E LMRFLPTE E L+ ++
Sbjct: 709 LIEANRAKNLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRF 768
Query: 698 ERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASV 757
ERE++P+EEL+ EDRFML FS++ RL +RM + FLGNF D Q+L PQLNAIIAAS S+
Sbjct: 769 EREQRPMEELSEEDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSI 828
Query: 758 KSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVK 817
KSS KL+Q+LEI+LA GNYMNSSKRGA YGF+LQSLD LL+ KSTDRK TLLH++ +
Sbjct: 829 KSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIA 888
Query: 818 EKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDN-SVLRNFLST 876
EKYP L F +LHF++KA +VSL++VL DV+ L RG+EL +RE D+ VL+ FL
Sbjct: 889 EKYPQLTGFHSDLHFLDKAGSVSLDSVLADVRSLQRGLELTQREFVRQDDCMVLKEFLRA 948
Query: 877 NEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARK 936
N +DKL D+KTA+EA+ +VV YFGE+PKTT P +FF +F RFI++YK+AEQE E K
Sbjct: 949 NSPTMDKLLADSKTAQEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQWK 1008
Query: 937 KQEEVMREKQLAQEAKKLDAKTPSQRNKWQ--QQELIAELRRRQAKEHRPVYEGKDGTIE 994
K E ++ A K + P K + Q +LI+EL+RRQ KE +DG IE
Sbjct: 1009 K--EAAAQEAGADTPGKGEPPAPKSPPKARRPQMDLISELKRRQQKEPLIYESDRDGAIE 1066
Query: 995 DIITGLHCQPMVVRHQARSA 1014
DIIT + P R R++
Sbjct: 1067 DIITVIKTVPFTARTGKRTS 1086
>gi|40548415 dishevelled associated activator of morphogenesis 2 [Homo
sapiens]
Length = 1067
Score = 328 bits (840), Expect = 2e-89
Identities = 247/862 (28%), Positives = 417/862 (48%), Gaps = 139/862 (16%)
Query: 224 VHVCIL-CLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGG 282
+H ++ C++A+MN G V++ P A++ IA SL +N +TK VLE+L AVCLV GG
Sbjct: 173 IHTSLIGCIKALMNNSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGG 232
Query: 283 HEIILAAFDNFKEVCKELHRFEKLME-------YFRNEDSNIDFMVACMQFINIVVHS-- 333
H+ +L A +++ E RF+ L+ +R+E ++ A M FIN V+++
Sbjct: 233 HKKVLQAMLHYQVYAAERTRFQTLLNELDRSLGRYRDE---VNLKTAIMSFINAVLNAGA 289
Query: 334 -VEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAY----------LDNVFDV- 381
+++ FR+HL+YEF LG++ + K R E+ L + + L FD+
Sbjct: 290 GEDNLEFRLHLRYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMV 349
Query: 382 ------------------------------------------GGLLEDAETKNVALEKVE 399
GG + + + L+++
Sbjct: 350 HIDTKSASQMFELIHKKLKYTEAYPCLLSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIV 409
Query: 400 ELEEHVSHLTEKLLDLENENMMRVAELEKQLLQREKELESIKETYEN-TSHQVHTLRRLI 458
+E + L LEN N+ + +L E E++ ++ E + + RL
Sbjct: 410 LQDER--GVDPDLAPLENFNVKNIV----NMLINENEVKQWRDQAEKFRKEHMELVSRLE 463
Query: 459 KEKEEAFQRRCHLEPNVRGLESV------DSEAL--ARVGPAELSEGMPPSDLDLLAPAP 510
+++ E + E +R L + +S+ L AR AEL + ++ P
Sbjct: 464 RKERECETKTLEKEEMMRTLNKMKDKLARESQELRQARGQVAELVAQLSELSTGPVSSPP 523
Query: 511 PPEEVLPLP--------PPPAPPL------PPPPPPLPDKCPPAPPLPGAAPSVVLTVGL 556
PP L L PPP PPL PPPPPPLP PP P PGA P + + + L
Sbjct: 524 PPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGPPTP--PGAPPCLGMGLPL 581
Query: 557 S---------AIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDLDLDKFE 607
+R K+ + L FNW L ++ GTV++E+DD ++ LDL+ FE
Sbjct: 582 PQDPYPSSDVPLRKKRVPQPSHPLKSFNWVKLNEERVPGTVWNEIDDMQVFRILDLEDFE 641
Query: 608 ELFKT-----KAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEIC 662
++F K G D+ + K ++++++ RA+N I L K S EEI
Sbjct: 642 KMFSAYQRHQKELGSTEDIYLASRK-----VKELSVIDGRRAQNCIILLSKLKLSNEEIR 696
Query: 663 RAIHTFDLQ-TLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVE 721
+AI D Q L D +E L++F+P ++++ LL +++ E +E +A DRF+ S+++
Sbjct: 697 QAILKMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHE---IERMARADRFLYEMSRID 753
Query: 722 RLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSK 781
QR+ + F FQ+ L P++ AI+ AS + S++L+QMLE+ILA+GN+MN +
Sbjct: 754 HYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELVRSKRLRQMLEVILAIGNFMNKGQ 813
Query: 782 RGAVYGFKLQSLDLLLDTKST-DRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS 840
RG YGF++ SL+ + DTKS+ DR ++LLH++ + +++ +PD+ N EL + +AA V+
Sbjct: 814 RGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELQHLPEAAKVN 873
Query: 841 LENVLLDVKELGRGMELIR---------RECSIHDNSVLRNFLSTNEGKLDKLQRDAKTA 891
L + +V L RG+ + RE S V+ +F++ + +L+ A
Sbjct: 874 LAELEKEVGNLRRGLRAVEVLEYQRRQVREPSDKFVPVMSDFITVSSFSFSELEDQLNEA 933
Query: 892 EEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEA--RKKQEEVMREKQLAQ 949
+ + + +FGE P FF +F F++++ EA Q+ EA R+K+EE R + A
Sbjct: 934 RDKFAKALMHFGEHDSKMQPDEFFGIFDTFLQAFSEARQDLEAMRRRKEEEERRARMEAM 993
Query: 950 EAKKLDAKTPSQRNKWQQQELI 971
K +R +WQ+Q +
Sbjct: 994 ------LKEQRERERWQRQRKV 1009
>gi|21071077 dishevelled-associated activator of morphogenesis 1 [Homo
sapiens]
Length = 1078
Score = 295 bits (755), Expect = 1e-79
Identities = 243/907 (26%), Positives = 420/907 (46%), Gaps = 149/907 (16%)
Query: 212 LKNSRLVSQKDDVHVCIL-CLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVL 270
LK + + +H ++ C++A+MN G V++H ++N IA SL+ +N +TK VL
Sbjct: 165 LKTMDYETSESRIHTSLIGCIKALMNNSQGRAHVLAHSESINVIAQSLSTENIKTKVAVL 224
Query: 271 ELLAAVCLVRGGHEIILAAFDNFKEVCKELHRFEKLME-------YFRNEDSNIDFMVAC 323
E+L AVCLV GGH+ +L A ++++ E RF+ L+ +R+E + A
Sbjct: 225 EILGAVCLVPGGHKKVLQAMLHYQKYASERTRFQTLINDLDKSTGRYRDE---VSLKTAI 281
Query: 324 MQFINIVVH---SVEDMNFRVHLQYEFTKLGLEEFLQKSRHTES----------EKLQVQ 370
M FIN V+ VE ++FR+HL+YEF LG++ + K R E+ E L+ +
Sbjct: 282 MSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEMLRNE 341
Query: 371 IQAYLDNVFDVGGLLEDAETKNVALEKV----EELEEHVSHLTEKLLDLENENMMRVAE- 425
+ F++ + + T+ L + E H + L + + +
Sbjct: 342 DELEFAKRFELVHIDTKSATQMFELTRKRLTHSEAYPHFMSILHHCLQMPYKRSGNTVQY 401
Query: 426 -------LEKQLLQREKELESIKETYENTSHQVHTLRRLIKE------KEEAFQRRCHLE 472
+++ ++Q +K + EN + + + +R L+ E KE+A + R
Sbjct: 402 WLLLDRIIQQIVIQNDKGQDPDSTPLENFNIK-NVVRMLVNENEVKQWKEQAEKMRKEHN 460
Query: 473 PNVRGLESVDSEALARVGPAE-----LSEGMPPSDLDLLAPAPPPEEVLPL--------- 518
+ LE + E A+ E L++ + + ++V L
Sbjct: 461 ELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKETTEHKQVKQQVADLTAQLHELSR 520
Query: 519 -------PPPPAPPLP--PPPPPLPDKC---PPAPPLPGA-------------------- 546
P P+P P P P +P PP PPLPG
Sbjct: 521 RAVCASIPGGPSPGAPGGPFPSSVPGSLLPPPPPPPLPGGMLPPPPPPLPPGGPPPPPGP 580
Query: 547 --------APSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKIL 598
P + + L I +P L FNW+ L N++ GTV++E+DD K+
Sbjct: 581 PPLGAIMPPPGAPMGLALKKKSIPQPTNA---LKSFNWSKLPENKLEGTVWTEIDDTKVF 637
Query: 599 EDLDLDKFEELFKTKAQGPALDLICSKNKTAQKA------------ASKVTLLEANRAKN 646
+ LDL+ E F A D + N ++A ++++++ RA+N
Sbjct: 638 KILDLEDLERTF--SAYQRQQDFFVNSNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQN 695
Query: 647 LAITLRKAGRSAEEICRAIHTFDLQ-TLPVDFVECLMRFLPTEAEVKLLRQYERERQPLE 705
I L + S +EI RAI T D Q LP D +E L++F+P ++++ LL +++ E L+
Sbjct: 696 CNILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHE---LD 752
Query: 706 ELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQ 765
+A DRF+ S++ QR+ + F F + + + P++ AI + S V S LKQ
Sbjct: 753 RMAKADRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQ 812
Query: 766 MLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKST-DRKMTLLHFIALTVKEKYPDLA 824
+LE++LA GNYMN +RG YGFK+ SL+ + DTKS+ D+ +TLLH++ V+ KYP +
Sbjct: 813 LLEVVLAFGNYMNKGQRGNAYGFKISSLNKIADTKSSIDKNITLLHYLITIVENKYPSVL 872
Query: 825 NFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDN----------SVLRNFL 874
N EL + +AA V++ + ++ L G++ + E + SV+ F+
Sbjct: 873 NLNEELRDIPQAAKVNMTELDKEISTLRSGLKAVETELEYQKSQPPQPGDKFVSVVSQFI 932
Query: 875 STNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENE- 933
+ ++ A++ + V++FGE P FF +F +F+++ EA+QENE
Sbjct: 933 TVASFSFSDVEDLLAEAKDLFTKAVKHFGEEAGKIQPDEFFGIFDQFLQAVSEAKQENEN 992
Query: 934 ARKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTI 993
RKK+EE R +++A+ QR + E + R+AKE+ + G
Sbjct: 993 MRKKKEEEERR-------ARMEAQLKEQRER--------ERKMRKAKEN----SEESGEF 1033
Query: 994 EDIITGL 1000
+D+++ L
Sbjct: 1034 DDLVSAL 1040
Score = 47.4 bits (111), Expect = 7e-05
Identities = 34/139 (24%), Positives = 64/139 (46%), Gaps = 13/139 (9%)
Query: 26 MPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNP-----PH 80
+PMP EL+ F+ ++ ++L + EKKW + C +++ Q +N P
Sbjct: 45 LPMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKKWQIYCSKKKDQEENKGATSWPE 104
Query: 81 TYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLV 140
YI +L S + +E +K + L+ +LRT + +V F++ + GL ++
Sbjct: 105 FYIDQLNSMAARKSLLALEKEEEEERSKTIESLKTALRTKPMRFVTRFIDLD--GLSCIL 162
Query: 141 DYLSFAQCSVMFDFEGLES 159
++L D+E ES
Sbjct: 163 NFLK------TMDYETSES 175
>gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens]
Length = 1193
Score = 285 bits (730), Expect = 1e-76
Identities = 218/823 (26%), Positives = 402/823 (48%), Gaps = 94/823 (11%)
Query: 221 KDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVR 280
K + H I CL+A+MN QYG +MS +++ +A +++ ++P V++LL+AVC+V
Sbjct: 240 KKNQHKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVG 299
Query: 281 GGH--EIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMN 338
E +L A + E K++ RF ++E R+ +++ VACMQ IN +V S +D++
Sbjct: 300 EESILEEVLEALTSAGEE-KKIDRFFCIVEGLRH--NSVQLQVACMQLINALVTSPDDLD 356
Query: 339 FRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAY----LDNVFDVGGLLEDAETK--- 391
FR+H++ EF + GL+E L + +++ L +Q++ + +++F++ LED +
Sbjct: 357 FRLHIRNEFMRCGLKEILPNLKCIKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDE 416
Query: 392 -----NVALEKVEEL--EEHVSHLTEKLLDLENENMMR------VAELEKQLLQREKELE 438
N+ V+E E + + + LL + N+ +R + E Q++ ++
Sbjct: 417 AYDVYNMVWSTVKETRAEGYFISILQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMD 476
Query: 439 ------------------------SIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPN 474
++E E S L K+ E+ F +
Sbjct: 477 PDFTYRKRLDLDLTQFVDICIDQAKLEEFEEKASE-------LYKKFEKEFTDHQETQAE 529
Query: 475 VRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEE------VLPLPPP------- 521
++ E+ +E A + + G P+D ++ P PP +E LP PPP
Sbjct: 530 LQKKEAKINELQAELQAFKSQFGALPADCNI--PLPPSKEGGTGHSALPPPPPLPSGGGV 587
Query: 522 PAPPLPPPPPPLPDK-------CPPAPPLP--GAAPSVVLTVGLSAIRIKKPIKTKFRLP 572
P PP PPPPPPLP PP PPL G S L + ++ KK K + +
Sbjct: 588 PPPPPPPPPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLPILPFGLKPKKEFKPEISMR 647
Query: 573 VFNWTALKPNQISGTVFSELDDEKILEDLDL-DKFEELFKTKAQGPALDLICSKNKTAQK 631
NW ++P++++ F +E E++DL K E F + + + + K+ +K
Sbjct: 648 RLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDIEEKKSIKK 707
Query: 632 AASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEV 691
++ L++ A+NL+I L EEI I D L ++ L++ LP + ++
Sbjct: 708 KIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQL 767
Query: 692 KLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAII 751
L Q++ E L ++F+++ S V+RL R++ + F F++ + + P + A+
Sbjct: 768 NSLSQFKSE---YSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVS 824
Query: 752 AASASVKSSQKLKQMLEIILALGNYMNSSKRGA-VYGFKLQSLDLLLDTKSTDRKMTLLH 810
A +K S+ ++LE++L +GNYMN+ R A +GF L SL L DTKS D+K TLLH
Sbjct: 825 TACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLH 884
Query: 811 FIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRREC-------S 863
F+ +EKYPD+ NF +L ++KA+ VS+E + +++++GR ++ + +E
Sbjct: 885 FLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKELETFPPPED 944
Query: 864 IHDNSV--LRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRF 921
+HD V + F+ + + + + L + + E+ Y +++ Y+ K F F
Sbjct: 945 LHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNF 1004
Query: 922 IRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNK 964
++ +A +EN +++ EE + ++A+E + + Q+ K
Sbjct: 1005 RTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKK 1047
>gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens]
Length = 849
Score = 263 bits (671), Expect = 8e-70
Identities = 207/799 (25%), Positives = 387/799 (48%), Gaps = 94/799 (11%)
Query: 245 MSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGH--EIILAAFDNFKEVCKELHR 302
MS +++ +A +++ ++P V++LL+AVC+V E +L A + E K++ R
Sbjct: 1 MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEE-KKIDR 59
Query: 303 FEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHT 362
F ++E R+ +++ VACMQ IN +V S +D++FR+H++ EF + GL+E L +
Sbjct: 60 FFCIVEGLRH--NSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCI 117
Query: 363 ESEKLQVQIQAY----LDNVFDVGGLLEDAETK--------NVALEKVEEL--EEHVSHL 408
+++ L +Q++ + +++F++ LED + N+ V+E E + +
Sbjct: 118 KNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISI 177
Query: 409 TEKLLDLENENMMR------VAELEKQLLQREKELE------------------------ 438
+ LL + N+ +R + E Q++ ++
Sbjct: 178 LQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQA 237
Query: 439 SIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGPAELSEGM 498
++E E S L K+ E+ F + ++ E+ +E A + + G
Sbjct: 238 KLEEFEEKASE-------LYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGA 290
Query: 499 PPSDLDLLAPAPPPEE------VLPLPPP-------PAPPLPPPPPPLPDK-------CP 538
P+D ++ P PP +E LP PPP P PP PPPPPPLP P
Sbjct: 291 LPADCNI--PLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVP 348
Query: 539 PAPPLP--GAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEK 596
P PPL G S L + ++ KK K + + NW ++P++++ F +E
Sbjct: 349 PPPPLGFLGGQNSPPLPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNEN 408
Query: 597 ILEDLDL-DKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAG 655
E++DL K E F + + + + K+ +K ++ L++ A+NL+I L
Sbjct: 409 KYENVDLLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFR 468
Query: 656 RSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFML 715
EEI I D L ++ L++ LP + ++ L Q++ E L ++F++
Sbjct: 469 VPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSE---YSNLCEPEQFVV 525
Query: 716 LFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGN 775
+ S V+RL R++ + F F++ + + P + A+ A +K S+ ++LE++L +GN
Sbjct: 526 VMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGN 585
Query: 776 YMNSSKRGA-VYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVE 834
YMN+ R A +GF L SL L DTKS D+K TLLHF+ +EKYPD+ NF +L ++
Sbjct: 586 YMNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLD 645
Query: 835 KAAAVSLENVLLDVKELGRGMELIRREC-------SIHDNSV--LRNFLSTNEGKLDKLQ 885
KA+ VS+E + +++++GR ++ + +E +HD V + F+ + + + + L
Sbjct: 646 KASKVSVETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLS 705
Query: 886 RDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREK 945
+ + E+ Y +++ Y+ K F F ++ +A +EN +++ EE +
Sbjct: 706 KLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRV 765
Query: 946 QLAQEAKKLDAKTPSQRNK 964
++A+E + + Q+ K
Sbjct: 766 RIAKELAERERLERQQKKK 784
>gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]
Length = 1096
Score = 256 bits (655), Expect = 6e-68
Identities = 224/831 (26%), Positives = 372/831 (44%), Gaps = 100/831 (12%)
Query: 221 KDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVR 280
K + + I CL+A MN ++G ++ ++ +A +++ K P ++++L+A+C+V
Sbjct: 227 KKNQYKLIQCLKAFMNNKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIV- 285
Query: 281 GGHEIILAAFDNFKEVCKELH---RFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDM 337
G E IL E + RF ++E N+++ + VACMQFIN +V S ++
Sbjct: 286 -GEENILDKLLGAITTAAERNNRERFSPIVEGLENQEA-LQLQVACMQFINALVTSPYEL 343
Query: 338 NFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFD----------------- 380
+FR+HL+ EF + GL+ L + E+++L +Q++ + +N D
Sbjct: 344 DFRIHLRNEFLRSGLKTMLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMD 403
Query: 381 --------VGGLLEDAETKNVALEKVEE-----------------LEEHVSHLT------ 409
+ +L+D +N L ++ +EE VS +
Sbjct: 404 DMNEVYHLLYNMLKDTAAENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGM 463
Query: 410 ------EKLLDLENENMM-------RVAELEKQLLQREKELESIKETYENTSHQVHTLRR 456
+ LD++ +++ +V E E++ + K+ + + ++
Sbjct: 464 DPDFKYRQRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDEEFTARQEAQAELQKRDE 523
Query: 457 LIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVL 516
IKE E Q+ L + L S P G PP PAPP
Sbjct: 524 KIKELEAEIQQ---LRTQAQVLSSSSGIPGPPAAPPLPGVGPPPPP-----PAPPLPGGA 575
Query: 517 PLPPPPAP-------PLPPPPPPLPDKCPPAPPLPGAAPSVVLTVGLS-AIRIKKPIKTK 568
PLPPPP P P PPPPP L PP PPL G P +++ L ++ KK K +
Sbjct: 576 PLPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLGGVPPPPGISLNLPYGMKQKKMYKPE 635
Query: 569 FRLPVFNWTALKPNQISGTVFSELDDEKILEDLDL-DKFEELFKT--KAQGPALDLICSK 625
+ NW+ ++P ++S F E E+ DL K F T K Q A L K
Sbjct: 636 VSMKRINWSKIEPTELSENCFWLRVKEDKFENPDLFAKLALNFATQIKVQKNAEALEEKK 695
Query: 626 NKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFL 685
+K ++ +L+ A+NL+I L E+I I + L ++ L++ L
Sbjct: 696 TGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHL 755
Query: 686 PTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTP 745
P E K+L + + ++L ++F ++ S V+ L R++ + F F++++ + P
Sbjct: 756 P---EQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIKP 812
Query: 746 QLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGA-VYGFKLQSLDLLLDTKSTDR 804
+ A+ A +K S+ ++LE++L +GNYMNS R A GFK+ L + DTKS D+
Sbjct: 813 SIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSADQ 872
Query: 805 KMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS-------LENVLLDVKELGRGMEL 857
K TLLHFIA +EKY D+ F EL VE A+ VS L ++ + L R ++
Sbjct: 873 KTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIKK 932
Query: 858 IRRECSIHDNSV--LRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFF 915
+ + HD V + +F T + +KL + Y + YF KT FF
Sbjct: 933 FPQAENQHDKFVEKMTSFTKTAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEEFF 992
Query: 916 PVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQ 966
F + EA +EN R++ EE R +LA+E K K Q+ K Q
Sbjct: 993 GDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKE-KAEQEKLERQKKKKQ 1042
Score = 30.4 bits (67), Expect = 8.9
Identities = 28/118 (23%), Positives = 51/118 (43%), Gaps = 16/118 (13%)
Query: 33 ELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQ-----ERFQVKNPPHTYIQKLQ 87
E+ + F ++ MNL +K LR D K +++ + +KN H Q
Sbjct: 105 EVLDLFEKMMEDMNLNEEKKAPLRNKDFTTKREMVVQYISATAKSGGLKNSKHECTLSSQ 164
Query: 88 SFLDPSVTRKKFRRRVQESTKV--LRELEISLRTNHIGWVREFLNDENKGLDVLVDYL 143
++ + R + + + L L +SL +N + WV F ++GL +L+D L
Sbjct: 165 EYVH------ELRSGISDEKLLNCLESLRVSLTSNPVSWVNNF---GHEGLGLLLDEL 213
>gi|5803003 diaphanous 2 isoform 156 [Homo sapiens]
Length = 1101
Score = 256 bits (655), Expect = 6e-68
Identities = 224/831 (26%), Positives = 372/831 (44%), Gaps = 100/831 (12%)
Query: 221 KDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVR 280
K + + I CL+A MN ++G ++ ++ +A +++ K P ++++L+A+C+V
Sbjct: 227 KKNQYKLIQCLKAFMNNKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIV- 285
Query: 281 GGHEIILAAFDNFKEVCKELH---RFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDM 337
G E IL E + RF ++E N+++ + VACMQFIN +V S ++
Sbjct: 286 -GEENILDKLLGAITTAAERNNRERFSPIVEGLENQEA-LQLQVACMQFINALVTSPYEL 343
Query: 338 NFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFD----------------- 380
+FR+HL+ EF + GL+ L + E+++L +Q++ + +N D
Sbjct: 344 DFRIHLRNEFLRSGLKTMLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMD 403
Query: 381 --------VGGLLEDAETKNVALEKVEE-----------------LEEHVSHLT------ 409
+ +L+D +N L ++ +EE VS +
Sbjct: 404 DMNEVYHLLYNMLKDTAAENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGM 463
Query: 410 ------EKLLDLENENMM-------RVAELEKQLLQREKELESIKETYENTSHQVHTLRR 456
+ LD++ +++ +V E E++ + K+ + + ++
Sbjct: 464 DPDFKYRQRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDEEFTARQEAQAELQKRDE 523
Query: 457 LIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVL 516
IKE E Q+ L + L S P G PP PAPP
Sbjct: 524 KIKELEAEIQQ---LRTQAQVLSSSSGIPGPPAAPPLPGVGPPPPP-----PAPPLPGGA 575
Query: 517 PLPPPPAP-------PLPPPPPPLPDKCPPAPPLPGAAPSVVLTVGLS-AIRIKKPIKTK 568
PLPPPP P P PPPPP L PP PPL G P +++ L ++ KK K +
Sbjct: 576 PLPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLGGVPPPPGISLNLPYGMKQKKMYKPE 635
Query: 569 FRLPVFNWTALKPNQISGTVFSELDDEKILEDLDL-DKFEELFKT--KAQGPALDLICSK 625
+ NW+ ++P ++S F E E+ DL K F T K Q A L K
Sbjct: 636 VSMKRINWSKIEPTELSENCFWLRVKEDKFENPDLFAKLALNFATQIKVQKNAEALEEKK 695
Query: 626 NKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFL 685
+K ++ +L+ A+NL+I L E+I I + L ++ L++ L
Sbjct: 696 TGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHL 755
Query: 686 PTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTP 745
P E K+L + + ++L ++F ++ S V+ L R++ + F F++++ + P
Sbjct: 756 P---EQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIKP 812
Query: 746 QLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGA-VYGFKLQSLDLLLDTKSTDR 804
+ A+ A +K S+ ++LE++L +GNYMNS R A GFK+ L + DTKS D+
Sbjct: 813 SIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSADQ 872
Query: 805 KMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS-------LENVLLDVKELGRGMEL 857
K TLLHFIA +EKY D+ F EL VE A+ VS L ++ + L R ++
Sbjct: 873 KTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIKK 932
Query: 858 IRRECSIHDNSV--LRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFF 915
+ + HD V + +F T + +KL + Y + YF KT FF
Sbjct: 933 FPQAENQHDKFVEKMTSFTKTAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEEFF 992
Query: 916 PVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQ 966
F + EA +EN R++ EE R +LA+E K K Q+ K Q
Sbjct: 993 GDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKE-KAEQEKLERQKKKKQ 1042
Score = 30.4 bits (67), Expect = 8.9
Identities = 28/118 (23%), Positives = 51/118 (43%), Gaps = 16/118 (13%)
Query: 33 ELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQ-----ERFQVKNPPHTYIQKLQ 87
E+ + F ++ MNL +K LR D K +++ + +KN H Q
Sbjct: 105 EVLDLFEKMMEDMNLNEEKKAPLRNKDFTTKREMVVQYISATAKSGGLKNSKHECTLSSQ 164
Query: 88 SFLDPSVTRKKFRRRVQESTKV--LRELEISLRTNHIGWVREFLNDENKGLDVLVDYL 143
++ + R + + + L L +SL +N + WV F ++GL +L+D L
Sbjct: 165 EYVH------ELRSGISDEKLLNCLESLRVSLTSNPVSWVNNF---GHEGLGLLLDEL 213
>gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]
Length = 1240
Score = 206 bits (523), Expect = 1e-52
Identities = 222/893 (24%), Positives = 373/893 (41%), Gaps = 154/893 (17%)
Query: 227 CILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRG-GHEI 285
C+ C+RA+MN + G ++S+ V +++ +L+ N K V ELLAA+C+ GH +
Sbjct: 101 CVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVL 160
Query: 286 ILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQY 345
L A D++K VC + +RF +M D N+ ++V + IN V+ ED+ R L+
Sbjct: 161 TLDALDHYKTVCSQQYRFSIVMNELSGSD-NVPYVVTLLSVINAVILGPEDLRARTQLRN 219
Query: 346 EFTKLGLEEFLQKSRHTESEKLQVQIQAYLD-------NVFDVGGLLEDAETKNV----- 393
EF L L + L + R E L +Q++A+ + + V G ++ + + V
Sbjct: 220 EFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLF 279
Query: 394 --------------ALEKVEELEEHVSH---LTEKLLDLENENMMRVAELEKQLLQREKE 436
L+ + LE + L E L L N ++ ++ ++ L+ E
Sbjct: 280 HKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQECTLEEVVE 339
Query: 437 -LESIKETYENT----SHQVHTLRRLIKEKEEAFQRRCHLEPNVRG-----------LES 480
L S+K + +H+ ++ + Q +P+V G ++
Sbjct: 340 RLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDH 399
Query: 481 VDSEALARVGPAELSEGM-----PPSDLDLLA------PAPPPEEVLP---------LPP 520
SE++ +V E PP LL P PPP LP PP
Sbjct: 400 AQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPP 459
Query: 521 PP--------APPLPPPPPPLPDKC----PPAPPLPGAA---PSVVLTVGL--------- 556
PP APP PP PPPLP C PP PPLPG P L G+
Sbjct: 460 PPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPP 519
Query: 557 ---------------------------------SAIRIKKPIKTKFRLPVFNWTALKPN- 582
S R+ P R+ NW L N
Sbjct: 520 PLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPP---TLRMKKLNWQKLPSNV 576
Query: 583 -QISGTVFSELD--DEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLL 639
+ ++++ L D + +E D E LF A P + + A+K ++T L
Sbjct: 577 AREHNSMWASLSSPDAEAVEP-DFSSIERLFSFPAAKPKEPTMVAPR--ARKEPKEITFL 633
Query: 640 EANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYER 699
+A ++ NL I L++ S EE+ I D V+ ++ L++ LP + E++ LR +
Sbjct: 634 DAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTE 693
Query: 700 ERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKS 759
ER +LA+ D F LL + R+ M L M+ P+ ++AA S+ +
Sbjct: 694 ER---AKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLT 750
Query: 760 SQKLKQMLEIILALGNYMN-SSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKE 818
S++L ++IL +GN++N S G GFK+ +L L +TKS ++TLLH + ++
Sbjct: 751 SRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEK 810
Query: 819 KYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNF---LS 875
+PDL +L +AA ++LE + + + + R+ S V + L
Sbjct: 811 SHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTERLQ 870
Query: 876 TNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEAR 935
+ L + E+ + Y E + F F + A +EN+ R
Sbjct: 871 ASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDR 930
Query: 936 KKQ--EEVMREKQLAQEAKKL----DAKTPSQRNKWQQQE------LIAELRR 976
K+Q + R++QLA+E + D K P ++ +Q+E L+A++R+
Sbjct: 931 KEQAAKAERRKQQLAEEEARRPRGEDGK-PVRKGPGKQEEVCVIDALLADIRK 982
>gi|149999380 inverted formin 2 isoform 1 [Homo sapiens]
Length = 1249
Score = 206 bits (523), Expect = 1e-52
Identities = 222/893 (24%), Positives = 373/893 (41%), Gaps = 154/893 (17%)
Query: 227 CILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRG-GHEI 285
C+ C+RA+MN + G ++S+ V +++ +L+ N K V ELLAA+C+ GH +
Sbjct: 101 CVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVL 160
Query: 286 ILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQY 345
L A D++K VC + +RF +M D N+ ++V + IN V+ ED+ R L+
Sbjct: 161 TLDALDHYKTVCSQQYRFSIVMNELSGSD-NVPYVVTLLSVINAVILGPEDLRARTQLRN 219
Query: 346 EFTKLGLEEFLQKSRHTESEKLQVQIQAYLD-------NVFDVGGLLEDAETKNV----- 393
EF L L + L + R E L +Q++A+ + + V G ++ + + V
Sbjct: 220 EFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLF 279
Query: 394 --------------ALEKVEELEEHVSH---LTEKLLDLENENMMRVAELEKQLLQREKE 436
L+ + LE + L E L L N ++ ++ ++ L+ E
Sbjct: 280 HKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQECTLEEVVE 339
Query: 437 -LESIKETYENT----SHQVHTLRRLIKEKEEAFQRRCHLEPNVRG-----------LES 480
L S+K + +H+ ++ + Q +P+V G ++
Sbjct: 340 RLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDH 399
Query: 481 VDSEALARVGPAELSEGM-----PPSDLDLLA------PAPPPEEVLP---------LPP 520
SE++ +V E PP LL P PPP LP PP
Sbjct: 400 AQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPP 459
Query: 521 PP--------APPLPPPPPPLPDKC----PPAPPLPGAA---PSVVLTVGL--------- 556
PP APP PP PPPLP C PP PPLPG P L G+
Sbjct: 460 PPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPP 519
Query: 557 ---------------------------------SAIRIKKPIKTKFRLPVFNWTALKPN- 582
S R+ P R+ NW L N
Sbjct: 520 PLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPP---TLRMKKLNWQKLPSNV 576
Query: 583 -QISGTVFSELD--DEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLL 639
+ ++++ L D + +E D E LF A P + + A+K ++T L
Sbjct: 577 AREHNSMWASLSSPDAEAVEP-DFSSIERLFSFPAAKPKEPTMVAPR--ARKEPKEITFL 633
Query: 640 EANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYER 699
+A ++ NL I L++ S EE+ I D V+ ++ L++ LP + E++ LR +
Sbjct: 634 DAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTE 693
Query: 700 ERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKS 759
ER +LA+ D F LL + R+ M L M+ P+ ++AA S+ +
Sbjct: 694 ER---AKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLT 750
Query: 760 SQKLKQMLEIILALGNYMN-SSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKE 818
S++L ++IL +GN++N S G GFK+ +L L +TKS ++TLLH + ++
Sbjct: 751 SRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEK 810
Query: 819 KYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNF---LS 875
+PDL +L +AA ++LE + + + + R+ S V + L
Sbjct: 811 SHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTERLQ 870
Query: 876 TNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEAR 935
+ L + E+ + Y E + F F + A +EN+ R
Sbjct: 871 ASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDR 930
Query: 936 KKQ--EEVMREKQLAQEAKKL----DAKTPSQRNKWQQQE------LIAELRR 976
K+Q + R++QLA+E + D K P ++ +Q+E L+A++R+
Sbjct: 931 KEQAAKAERRKQQLAEEEARRPRGEDGK-PVRKGPGKQEEVCVIDALLADIRK 982
>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
Length = 1263
Score = 191 bits (486), Expect = 2e-48
Identities = 151/535 (28%), Positives = 246/535 (45%), Gaps = 63/535 (11%)
Query: 484 EALARVGPAELSEGM---PPSDLDLLAPAPPPEEVLP----LPPPPAP-----PLPPPPP 531
E + P+ L G PP L A PPP LP +PPPP P +PPPPP
Sbjct: 650 EGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPP 709
Query: 532 PLPDK--CPPAPPLPG------------------------AAPSVVLTVGLSAIRIKKPI 565
PLP PP PP PG AAP VL GL+ ++ KP
Sbjct: 710 PLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAP--VLPFGLTPKKLYKP- 766
Query: 566 KTKFRLPVFNWTALKPNQISGTVF------SELDDEKILEDLDLDKFEELFKTKAQGPAL 619
+ + R P NW+ L +S F ++ ++ L L F KT
Sbjct: 767 EVQLRRP--NWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLT-FSAQTKTSKAKKDQ 823
Query: 620 DLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVE 679
+ K +K ++ +L++ A+NL+I L +EI I + L ++
Sbjct: 824 EGGEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQ 883
Query: 680 CLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDN 739
L++ +P ++K+L + + E ++LA ++F ++ V RL R+ + F F +
Sbjct: 884 NLIKQMPEPEQLKMLSELKDE---YDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQ 940
Query: 740 LQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGA-VYGFKLQSLDLLLD 798
++ + P++ ++ AA ++ S+ +LEI L +GNYMN+ R A +GF + L L D
Sbjct: 941 VENIKPEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRD 1000
Query: 799 TKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELI 858
TKSTD+KMTLLHF+A + YPD+ F EL VEKA+ VS EN+ ++ ++ + + +
Sbjct: 1001 TKSTDQKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDV 1060
Query: 859 RRECSIHDNSV---------LRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTT 909
R+ + + +F+ + + +KL+ E Y + YF PK
Sbjct: 1061 ERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKL 1120
Query: 910 PPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNK 964
FF F + +A +EN+ R++ EE MR +LA+E + + Q+ +
Sbjct: 1121 SVEEFFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKRE 1175
Score = 99.4 bits (246), Expect = 2e-20
Identities = 107/418 (25%), Positives = 173/418 (41%), Gaps = 106/418 (25%)
Query: 225 HVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLV---RG 281
H I CL+A MN ++G ++ + + +++ P +LL+A+C++
Sbjct: 206 HEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPED 265
Query: 282 GHEIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRV 341
+E +L A E+ E+ RF+ L++ ++ + I V C+Q IN ++ E+++FRV
Sbjct: 266 MNERVLEAMTERAEM-DEVERFQPLLDGLKS-GTTIALKVGCLQLINALITPAEELDFRV 323
Query: 342 HLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAY----LDNVFDVGGLLEDA--------E 389
H++ E +LGL + LQ R E+E ++VQ+ + ++ +D+ G L+D E
Sbjct: 324 HIRSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNE 383
Query: 390 TKNVALEKVEE--LEEHVSHLTEKLLDLENENMMR------------------------- 422
+ L V++ E H + + LL + N+ R
Sbjct: 384 VFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGADPDF 443
Query: 423 ----------------------------VAELEKQL---LQREKELESIKETYENTSHQV 451
AELEK+L L EL+ + E+ Q
Sbjct: 444 KCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQ- 502
Query: 452 HTLRRLIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGP------------AELSEG-- 497
L+ L EK+ + + + LE+ S+ V A LS
Sbjct: 503 -KLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAI 561
Query: 498 -MPPSDLDLLAPAPPPEEVLP------LPPPPAP---PLPPPPPPLPDKCPPAPPLPG 545
+PPS + AP PP LP +PPPPAP PPPPPP P PP PPLPG
Sbjct: 562 TVPPS-VPSRAPVPPAPP-LPGDSGTIIPPPPAPGDSTTPPPPPPPP---PPPPPLPG 614
Score = 63.9 bits (154), Expect = 7e-10
Identities = 62/196 (31%), Positives = 88/196 (44%), Gaps = 21/196 (10%)
Query: 358 KSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELE---EHVSHLTEKLLD 414
K RH LQ++I+ +D + D + E +E K LEK + E H + K ++
Sbjct: 444 KCRH-----LQIEIEGLIDQMIDKTKV-EKSEAKAAELEKKLDSELTARHELQVEMKKME 497
Query: 415 LENENMMRVAELEKQLLQREKE-LESIKETYE-NTSHQVHTLRRLIKEKEEAFQRRCHLE 472
+ E ++ + EK L EK+ + + K+ E S + +L KE E+A + L
Sbjct: 498 SDFEQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLS 557
Query: 473 PNVRGLE-SVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPP 531
+ SV S A P P D + P PP PPPP PP PPPPP
Sbjct: 558 AAAITVPPSVPSRAPVPPAPPL------PGDSGTIIPPPPAPGDSTTPPPPPPP-PPPPP 610
Query: 532 PLP-DKCPPAPP-LPG 545
PLP C +PP LPG
Sbjct: 611 PLPGGVCISSPPSLPG 626
>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
Length = 1272
Score = 191 bits (486), Expect = 2e-48
Identities = 151/535 (28%), Positives = 246/535 (45%), Gaps = 63/535 (11%)
Query: 484 EALARVGPAELSEGM---PPSDLDLLAPAPPPEEVLP----LPPPPAP-----PLPPPPP 531
E + P+ L G PP L A PPP LP +PPPP P +PPPPP
Sbjct: 659 EGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPP 718
Query: 532 PLPDK--CPPAPPLPG------------------------AAPSVVLTVGLSAIRIKKPI 565
PLP PP PP PG AAP VL GL+ ++ KP
Sbjct: 719 PLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAP--VLPFGLTPKKLYKP- 775
Query: 566 KTKFRLPVFNWTALKPNQISGTVF------SELDDEKILEDLDLDKFEELFKTKAQGPAL 619
+ + R P NW+ L +S F ++ ++ L L F KT
Sbjct: 776 EVQLRRP--NWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLT-FSAQTKTSKAKKDQ 832
Query: 620 DLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVE 679
+ K +K ++ +L++ A+NL+I L +EI I + L ++
Sbjct: 833 EGGEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQ 892
Query: 680 CLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDN 739
L++ +P ++K+L + + E ++LA ++F ++ V RL R+ + F F +
Sbjct: 893 NLIKQMPEPEQLKMLSELKDE---YDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQ 949
Query: 740 LQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGA-VYGFKLQSLDLLLD 798
++ + P++ ++ AA ++ S+ +LEI L +GNYMN+ R A +GF + L L D
Sbjct: 950 VENIKPEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRD 1009
Query: 799 TKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELI 858
TKSTD+KMTLLHF+A + YPD+ F EL VEKA+ VS EN+ ++ ++ + + +
Sbjct: 1010 TKSTDQKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDV 1069
Query: 859 RRECSIHDNSV---------LRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTT 909
R+ + + +F+ + + +KL+ E Y + YF PK
Sbjct: 1070 ERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKL 1129
Query: 910 PPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNK 964
FF F + +A +EN+ R++ EE MR +LA+E + + Q+ +
Sbjct: 1130 SVEEFFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKRE 1184
Score = 99.4 bits (246), Expect = 2e-20
Identities = 107/418 (25%), Positives = 173/418 (41%), Gaps = 106/418 (25%)
Query: 225 HVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLV---RG 281
H I CL+A MN ++G ++ + + +++ P +LL+A+C++
Sbjct: 215 HEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPED 274
Query: 282 GHEIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRV 341
+E +L A E+ E+ RF+ L++ ++ + I V C+Q IN ++ E+++FRV
Sbjct: 275 MNERVLEAMTERAEM-DEVERFQPLLDGLKS-GTTIALKVGCLQLINALITPAEELDFRV 332
Query: 342 HLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAY----LDNVFDVGGLLEDA--------E 389
H++ E +LGL + LQ R E+E ++VQ+ + ++ +D+ G L+D E
Sbjct: 333 HIRSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNE 392
Query: 390 TKNVALEKVEE--LEEHVSHLTEKLLDLENENMMR------------------------- 422
+ L V++ E H + + LL + N+ R
Sbjct: 393 VFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGADPDF 452
Query: 423 ----------------------------VAELEKQL---LQREKELESIKETYENTSHQV 451
AELEK+L L EL+ + E+ Q
Sbjct: 453 KCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQ- 511
Query: 452 HTLRRLIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGP------------AELSEG-- 497
L+ L EK+ + + + LE+ S+ V A LS
Sbjct: 512 -KLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAI 570
Query: 498 -MPPSDLDLLAPAPPPEEVLP------LPPPPAP---PLPPPPPPLPDKCPPAPPLPG 545
+PPS + AP PP LP +PPPPAP PPPPPP P PP PPLPG
Sbjct: 571 TVPPS-VPSRAPVPPAPP-LPGDSGTIIPPPPAPGDSTTPPPPPPPP---PPPPPLPG 623
Score = 63.9 bits (154), Expect = 7e-10
Identities = 62/196 (31%), Positives = 88/196 (44%), Gaps = 21/196 (10%)
Query: 358 KSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELE---EHVSHLTEKLLD 414
K RH LQ++I+ +D + D + E +E K LEK + E H + K ++
Sbjct: 453 KCRH-----LQIEIEGLIDQMIDKTKV-EKSEAKAAELEKKLDSELTARHELQVEMKKME 506
Query: 415 LENENMMRVAELEKQLLQREKE-LESIKETYE-NTSHQVHTLRRLIKEKEEAFQRRCHLE 472
+ E ++ + EK L EK+ + + K+ E S + +L KE E+A + L
Sbjct: 507 SDFEQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLS 566
Query: 473 PNVRGLE-SVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPP 531
+ SV S A P P D + P PP PPPP PP PPPPP
Sbjct: 567 AAAITVPPSVPSRAPVPPAPPL------PGDSGTIIPPPPAPGDSTTPPPPPPP-PPPPP 619
Query: 532 PLP-DKCPPAPP-LPG 545
PLP C +PP LPG
Sbjct: 620 PLPGGVCISSPPSLPG 635
>gi|145309324 FH2 domain containing 1 [Homo sapiens]
Length = 1143
Score = 166 bits (419), Expect = 1e-40
Identities = 136/471 (28%), Positives = 219/471 (46%), Gaps = 43/471 (9%)
Query: 508 PAPPPEEVLPLPPPPAPPL------------PPPPPPLPDKCPPAPPLPGAAPSVVLTVG 555
PAPPP P PPPP+PP PPPPPPLP + P PP PG P+ + G
Sbjct: 32 PAPPPP---PPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPPPPGLPPTTHMN-G 87
Query: 556 LSAIRIKKPIKTKFRLPVFNWTALKPNQISG--TVFSELDDEKILEDLDLDKFEELF--- 610
S + KK R+ F W + Q+ G +++ ++ +D EELF
Sbjct: 88 YSHLGKKK------RMRSFFWKTIPEEQVRGKTNIWTLAARQEHHYQIDTKTIEELFGQQ 141
Query: 611 --KTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTF 668
TK+ P + N + ++A ++T+L+A R+ N+ I L++ +S I IH
Sbjct: 142 EDTTKSSLPRRGR--TLNSSFREAREEITILDAKRSMNIGIFLKQFKKSPRSIVEDIHQG 199
Query: 669 DLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMA 728
+ + + ++FLP EVK L+ + + + +L+ D F+ +V + R+
Sbjct: 200 KSEHYGSETLREFLKFLPESEEVKKLKAFSGD---VSKLSLADSFLYGLIQVPNYSLRIE 256
Query: 729 GMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSK-RGAVYG 787
M F + L + + A + S ++L +L ++L GN MN+ G G
Sbjct: 257 AMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIMNAGGYAGNAVG 316
Query: 788 FKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENV--- 844
FKL SL L DTK+ M LLHF+A ++K L NF +LH V+K A +SLEN
Sbjct: 317 FKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLHHVQKTARLSLENTEAE 376
Query: 845 --LLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYF 902
LL V+ E I+R+ + + +FL KL +L+ + ++ ++ +F
Sbjct: 377 LHLLFVRTKSL-KENIQRDGELCQQ--MEDFLQFAIEKLRELECWKQELQDEAYTLIDFF 433
Query: 903 GESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKK 953
E KT F +F F + +A ++N R+ QE ++ QE K+
Sbjct: 434 CEDKKTMKLDECFQIFRDFCTKFNKAVKDNHDREAQELRQLQRLKEQEQKQ 484
>gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2)
interacting protein [Homo sapiens]
Length = 1211
Score = 144 bits (363), Expect = 4e-34
Identities = 129/476 (27%), Positives = 205/476 (43%), Gaps = 80/476 (16%)
Query: 510 PPPEEVLPLPPPPAPPLP----------------------------------PPPPPLPD 535
PPP PL PPP PPLP PPPPPLP
Sbjct: 750 PPP----PLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLPP 805
Query: 536 KCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDE 595
P APP+ L+ GL R + + RL W ++ ++ GT++ +L
Sbjct: 806 PVPCAPPM--------LSRGLGHRRSETSHMSVKRL---RWEQVENSE--GTIWGQLG-- 850
Query: 596 KILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQ--------KAASKVTLLEANRAKNL 647
ED D DK ++ K L+L K A+ + V +L +A N
Sbjct: 851 ---EDSDYDKLSDMVKYLD----LELHFGTQKPAKPVPGPEPFRKKEVVEILSHKKAYNT 903
Query: 648 AITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEEL 707
+I L S E+ + + + + + L + L+ F P E + +Y+ R+ L
Sbjct: 904 SILLAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQ---RYQAFREAPGRL 960
Query: 708 AAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQML 767
+ D+F+L V R+ + F Q+ + + L + AS +K+S+KL ++L
Sbjct: 961 SEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKIL 1020
Query: 768 EIILALGNYMNSS--KRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLAN 825
E +LA+GNY+N K GFK+ L L TK+ D K T LH +A ++ + +P+L
Sbjct: 1021 EFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLG 1080
Query: 826 FWHELHFVEKAAAVSLENVLLDVKELGRGMELIRREC-SIHDNS------VLRNFLSTNE 878
F +L V AA V+ + D+ +L + I+ C SI +S V+ +FL T +
Sbjct: 1081 FAQDLPTVPLAAKVNQRALTSDLADLHGTISEIQDACQSISPSSEDKFAMVMSSFLETAQ 1140
Query: 879 GKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEA 934
L L + A E + +FGE K T FF +F F+ ++ A + +A
Sbjct: 1141 PALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFAEFMSKFERALSDLQA 1196
>gi|157168329 formin 1 [Homo sapiens]
Length = 1196
Score = 138 bits (348), Expect = 2e-32
Identities = 138/562 (24%), Positives = 238/562 (42%), Gaps = 65/562 (11%)
Query: 471 LEPNVRGLESVDSEALARVGPAELSEGMP-PSDLDLLAPAPPPEEVLPLPPPPAPPLPPP 529
L+P + G+ S +AL PA + P PS L L+PAPP V PP P PP PPP
Sbjct: 631 LQP-MEGMASNQQKALPPP-PASIPPPPPLPSGLGSLSPAPPMPPVSAGPPLPPPPPPPP 688
Query: 530 P-----------------------PPLPDKCPPAPPLPGAA----PSVVLTVGLSAIRI- 561
P PP P PPAPP PG A P + +G S+ +
Sbjct: 689 PLPPPSSAGPPPPPPPPPLPNSPAPPNPGGPPPAPPPPGLAPPPPPGLFFGLGSSSSQCP 748
Query: 562 -KKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDL-DLDKFEELFKTKAQGPAL 619
K I+ + WT ++ + S L D D+ D +FE LF
Sbjct: 749 RKPAIEPSCPMKPLYWTRIQISDRSQNATPTLWDSLEEPDIRDPSEFEYLFSKDTTQQKK 808
Query: 620 DLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVE 679
+ + K + LL+ R++ + I + ++I +AI D + ++ +
Sbjct: 809 KPLSETYEKKNKVKKIIKLLDGKRSQTVGILISSLHLEMKDIQQAIFNVDDSVVDLETLA 868
Query: 680 CLMRFLPTEAE-VKLLRQYERER-QPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQ 737
L E E VK+ + YE + + L+ L ++F+ +++ +R + F F
Sbjct: 869 ALYENRAQEDELVKIRKYYETSKEEELKLLDKPEQFLHELAQIPNFAERAQCIIFRSVFS 928
Query: 738 DNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSK--RGAVYGFKLQSLDL 795
+ + L ++ I AS + + +K +L +ILA GNYMN RG G+ L+ L
Sbjct: 929 EGITSLHRKVEIITRASKDLLHVKSVKDILALILAFGNYMNGGNRTRGQADGYSLEILPK 988
Query: 796 LLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEK------AAAVSLENVLLDVK 849
L D KS D + L+ ++ Y A + + + A+ V E+++ D++
Sbjct: 989 LKDVKSRDNGINLVDYVVKYYLRYYDQEAGTEKSVFPLPEPQDFFLASQVKFEDLIKDLR 1048
Query: 850 ELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAK-----------TAEEAYNAV 898
+L R +E ++ + + +L + KL++ + AK A++++
Sbjct: 1049 KLKRQLEASEKQMVVVCKESPKEYLQPFKDKLEEFFQKAKKEHKMEESHLENAQKSFETT 1108
Query: 899 VRYFGESPKT----TPPSVFFPVFVRFIRSYK---EAEQENEARKKQEEVMREKQLAQEA 951
VRYFG PK+ PS F V+ F +K + E +N ++++ +
Sbjct: 1109 VRYFGMKPKSGEKEITPSYVFMVWYEFCSDFKTIWKRESKNISKERLKMAQESVSKLTSE 1168
Query: 952 KKLDAK----TPSQRNKWQQQE 969
KK++ K T S + + +Q+E
Sbjct: 1169 KKVETKKINPTASLKERLRQKE 1190
>gi|58331242 formin homology 2 domain containing 3 [Homo sapiens]
Length = 1439
Score = 116 bits (291), Expect = 9e-26
Identities = 91/350 (26%), Positives = 170/350 (48%), Gaps = 31/350 (8%)
Query: 508 PAPPPEEVLPLPPPPAPPL--PPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPI 565
P PPP L LPPPP PPL PPPP+P PP AP +G S + +P
Sbjct: 847 PPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPVFNAPQ---GLGWSQVPRGQPT 903
Query: 566 KTKFRLPV---------FNWTALKPNQISGTVFSELDDEKILEDLDLDKFEELFKTKAQG 616
TK + + F+W + ++S+L+ K+ D + E LF++K++
Sbjct: 904 FTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLEPIKV----DTSRLEHLFESKSK- 958
Query: 617 PALDLICSKNKTAQKAASKVTLLEANR--AKNLAITLRKAGRSAEEICRAIHTFDLQTLP 674
+L SK A ++ +L++ R A N+ +T+ R+ I AI FD L
Sbjct: 959 ---ELSVSKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPPRT---IKIAILNFDEYALN 1012
Query: 675 VDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLG 734
+ +E ++ +PT+ E + +++ + P L + ++F+L S + L+ R+ AF
Sbjct: 1013 KEGIEKILTMIPTDEEKQKIQEAQL-ANPEIPLGSAEQFLLTLSSISELSARLHLWAFKM 1071
Query: 735 NFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLD 794
+++ + + L + +++++ L +L +LA+GN++N + A F+L L+
Sbjct: 1072 DYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKA---FELSYLE 1128
Query: 795 LLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENV 844
+ + K T K +LLH + V E +PD ++ + E+ + ++A V + +
Sbjct: 1129 KVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQL 1178
Score = 33.1 bits (74), Expect = 1.4
Identities = 29/108 (26%), Positives = 48/108 (44%), Gaps = 3/108 (2%)
Query: 882 DKLQRDAKTAEEAYNAVVRYFGESPKTTPPS-VFFPVFVRFIRSYKEAEQENEARKKQEE 940
D ++ + +Y++ G S TTP S V P R RS + R+ QE
Sbjct: 395 DLREKYSNFGNNSYHSSRPSSGSSVPTTPTSSVSPPQEARLERSSPSGLLTSSFRQHQES 454
Query: 941 VM--REKQLAQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVY 986
+ RE++ + ++L +RNK+ + L +RQA+E R Y
Sbjct: 455 LAAERERRRQEREERLQRIEREERNKFSRDYLDKREEQRQAREERYKY 502
>gi|160707881 formin 2 [Homo sapiens]
Length = 1722
Score = 112 bits (281), Expect = 1e-24
Identities = 121/496 (24%), Positives = 218/496 (43%), Gaps = 60/496 (12%)
Query: 508 PAPPPEEVLPLPPPPAPPLP------PPPPPLPDKCPPAPP---------------LPGA 546
P PPP + +PP PAPPLP PPPP LP PP P LP
Sbjct: 1207 PPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPP 1266
Query: 547 APSVVLTVGLSAIR--IKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILE-DLDL 603
PS + +G++ + K+PI+ + WT ++ + + S L EKI E +D
Sbjct: 1267 LPSGLFGLGMNQDKGSRKQPIEPCRPMKPLYWTRIQLHSKRDSSTS-LIWEKIEEPSIDC 1325
Query: 604 DKFEELF-KTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEIC 662
+FEELF KT + + + +KT KA V LL R++ + I + ++I
Sbjct: 1326 HEFEELFSKTAVKERKKPISDTISKT--KAKQVVKLLSNKRSQAVGILMSSLHLDMKDIQ 1383
Query: 663 RAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYER---ERQPLEELAAEDRFMLLFSK 719
A+ D + ++ ++ L E++ + ++ R +++ + L ++F+ S
Sbjct: 1384 HAVVNLDNSVVDLETLQALYENRAQSDELEKIEKHGRSSKDKENAKSLDKPEQFLYELSL 1443
Query: 720 VERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMN- 778
+ ++R+ + F F +++ + +L + ++K+ + Q+L ++LA GNYMN
Sbjct: 1444 IPNFSERVFCILFQSTFSESICSIRRKLELLQKLCETLKNGPGVMQVLGLVLAFGNYMNG 1503
Query: 779 -SSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWH------ELH 831
+ RG GF L L L D KS+D +LL +I + + A E
Sbjct: 1504 GNKTRGQADGFGLDILPKLKDVKSSDNSRSLLSYIVSYYLRNFDEDAGKEQCLFPLPEPQ 1563
Query: 832 FVEKAAAVSLENVLLDVKELGRGMELIRREC----SIHDNSVLRNFLSTNE-----GKLD 882
+ +A+ + E+ D+++L + ++ E + ++ F E K+D
Sbjct: 1564 DLFQASQMKFEDFQKDLRKLKKDLKACEVEAGKVYQVSSKEHMQPFKENMEQFIIQAKID 1623
Query: 883 KLQRDAKTAE--EAYNAVVRYFGESP----KTTPPSVFFPVFVRFIRSYKEA-EQEN--- 932
+ + E + + YF P K P+ FF ++ F +K+ ++EN
Sbjct: 1624 QEAEENSLTETHKCFLETTAYFFMKPKLGEKEVSPNAFFSIWHEFSSDFKDFWKKENKLL 1683
Query: 933 --EARKKQEEVMREKQ 946
E K+ EEV R+K+
Sbjct: 1684 LQERVKEAEEVCRQKK 1699
Score = 53.5 bits (127), Expect = 1e-06
Identities = 33/79 (41%), Positives = 41/79 (51%), Gaps = 18/79 (22%)
Query: 480 SVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPP-------PAPPLP----P 528
++ S A+ + P + +E +PP P P P +P PPP P PPLP P
Sbjct: 890 TLPSTAIPQPPPLQGTEMLPPP------PPPLPGAGIPPPPPLPGAGILPLPPLPGAGIP 943
Query: 529 PPPPLPDKC-PPAPPLPGA 546
PPPPLP PP PPLPGA
Sbjct: 944 PPPPLPGAAIPPPPPLPGA 962
Score = 52.8 bits (125), Expect = 2e-06
Identities = 31/61 (50%), Positives = 33/61 (54%), Gaps = 13/61 (21%)
Query: 499 PPSDLDLLAPAPP-PEEVLPLPPP-------PAPPLP----PPPPPLPDK-CPPAPPLPG 545
PP + P PP P +PLPPP P PPLP PPPPPLP PP PPLPG
Sbjct: 946 PPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1005
Query: 546 A 546
A
Sbjct: 1006 A 1006
Score = 52.4 bits (124), Expect = 2e-06
Identities = 35/105 (33%), Positives = 43/105 (40%), Gaps = 21/105 (20%)
Query: 464 AFQRRCHLE-----PNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPL 518
AF+ C++ P S+ + P L P+ P PPP + +
Sbjct: 848 AFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEM 907
Query: 519 PPPPAPPLP----PPPPPLPDK------------CPPAPPLPGAA 547
PPP PPLP PPPPPLP PP PPLPGAA
Sbjct: 908 LPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAA 952
Score = 50.4 bits (119), Expect = 8e-06
Identities = 28/55 (50%), Positives = 31/55 (56%), Gaps = 5/55 (9%)
Query: 497 GMPPSDLDLLAPAPPPEEVLPLPPPPAPPLP----PPPPPLPDK-CPPAPPLPGA 546
G+PP A PPP + + PP PPLP PPPPPLP PP PPLPGA
Sbjct: 1084 GIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGA 1138
Score = 50.1 bits (118), Expect = 1e-05
Identities = 30/62 (48%), Positives = 32/62 (51%), Gaps = 19/62 (30%)
Query: 497 GMPPSDLDLLAPAPPPEEVLPLPPP-------PAPPLP----PPPPPLPDK-CPPAPPLP 544
G+PP P P P +P PPP P PPLP PPPPPLP PP PPLP
Sbjct: 974 GIPP-------PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1026
Query: 545 GA 546
GA
Sbjct: 1027 GA 1028
Score = 50.1 bits (118), Expect = 1e-05
Identities = 30/62 (48%), Positives = 32/62 (51%), Gaps = 19/62 (30%)
Query: 497 GMPPSDLDLLAPAPPPEEVLPLPPP-------PAPPLP----PPPPPLPDK-CPPAPPLP 544
G+PP P P P +P PPP P PPLP PPPPPLP PP PPLP
Sbjct: 985 GIPP-------PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1037
Query: 545 GA 546
GA
Sbjct: 1038 GA 1039
Score = 50.1 bits (118), Expect = 1e-05
Identities = 30/62 (48%), Positives = 32/62 (51%), Gaps = 19/62 (30%)
Query: 497 GMPPSDLDLLAPAPPPEEVLPLPPP-------PAPPLP----PPPPPLPDK-CPPAPPLP 544
G+PP P P P +P PPP P PPLP PPPPPLP PP PPLP
Sbjct: 996 GIPP-------PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1048
Query: 545 GA 546
GA
Sbjct: 1049 GA 1050
Score = 50.1 bits (118), Expect = 1e-05
Identities = 30/62 (48%), Positives = 32/62 (51%), Gaps = 19/62 (30%)
Query: 497 GMPPSDLDLLAPAPPPEEVLPLPPP-------PAPPLP----PPPPPLPDK-CPPAPPLP 544
G+PP P P P +P PPP P PPLP PPPPPLP PP PPLP
Sbjct: 1007 GIPP-------PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1059
Query: 545 GA 546
GA
Sbjct: 1060 GA 1061
Score = 50.1 bits (118), Expect = 1e-05
Identities = 30/62 (48%), Positives = 32/62 (51%), Gaps = 19/62 (30%)
Query: 497 GMPPSDLDLLAPAPPPEEVLPLPPP-------PAPPLP----PPPPPLPDK-CPPAPPLP 544
G+PP P P P +P PPP P PPLP PPPPPLP PP PPLP
Sbjct: 1018 GIPP-------PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1070
Query: 545 GA 546
GA
Sbjct: 1071 GA 1072
Score = 50.1 bits (118), Expect = 1e-05
Identities = 30/62 (48%), Positives = 32/62 (51%), Gaps = 19/62 (30%)
Query: 497 GMPPSDLDLLAPAPPPEEVLPLPPP-------PAPPLP----PPPPPLPDK-CPPAPPLP 544
G+PP P P P +P PPP P PPLP PPPPPLP PP PPLP
Sbjct: 1029 GIPP-------PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1081
Query: 545 GA 546
GA
Sbjct: 1082 GA 1083
Score = 50.1 bits (118), Expect = 1e-05
Identities = 30/62 (48%), Positives = 32/62 (51%), Gaps = 19/62 (30%)
Query: 497 GMPPSDLDLLAPAPPPEEVLPLPPP-------PAPPLP----PPPPPLPDK-CPPAPPLP 544
G+PP P P P +P PPP P PPLP PPPPPLP PP PPLP
Sbjct: 1040 GIPP-------PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1092
Query: 545 GA 546
GA
Sbjct: 1093 GA 1094
Score = 50.1 bits (118), Expect = 1e-05
Identities = 30/62 (48%), Positives = 32/62 (51%), Gaps = 19/62 (30%)
Query: 497 GMPPSDLDLLAPAPPPEEVLPLPPP-------PAPPLP----PPPPPLPDK-CPPAPPLP 544
G+PP P P P +P PPP P PPLP PPPPPLP PP PPLP
Sbjct: 1073 GIPP-------PPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLP 1125
Query: 545 GA 546
GA
Sbjct: 1126 GA 1127
Score = 50.1 bits (118), Expect = 1e-05
Identities = 30/62 (48%), Positives = 32/62 (51%), Gaps = 19/62 (30%)
Query: 497 GMPPSDLDLLAPAPPPEEVLPLPPP-------PAPPLP----PPPPPLPDK-CPPAPPLP 544
G+PP P P P +P PPP P PPLP PPPPPLP PP PPLP
Sbjct: 1117 GIPP-------PPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLP 1169
Query: 545 GA 546
GA
Sbjct: 1170 GA 1171
Score = 49.7 bits (117), Expect = 1e-05
Identities = 28/54 (51%), Positives = 30/54 (55%), Gaps = 7/54 (12%)
Query: 498 MPPSDLDLLAPAPPPEEVLPLPPPPAPPLP----PPPPPLPDK-CPPAPPLPGA 546
+PP P PPP +PPPP PLP PPPPPLP PP PPLPGA
Sbjct: 966 LPPPLPGAGIPPPPPLPGAGIPPPP--PLPGAGIPPPPPLPGAGIPPPPPLPGA 1017
Score = 49.7 bits (117), Expect = 1e-05
Identities = 30/62 (48%), Positives = 32/62 (51%), Gaps = 19/62 (30%)
Query: 497 GMPPSDLDLLAPAPPPEEVLPLPPP-------PAPPLP----PPPPPLPDK-CPPAPPLP 544
G+PP P P P +P PPP P PPLP PPPPPLP PP PPLP
Sbjct: 1062 GIPP-------PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLP 1114
Query: 545 GA 546
GA
Sbjct: 1115 GA 1116
Score = 49.7 bits (117), Expect = 1e-05
Identities = 30/62 (48%), Positives = 32/62 (51%), Gaps = 19/62 (30%)
Query: 497 GMPPSDLDLLAPAPPPEEVLPLPPP-------PAPPLP----PPPPPLPDK-CPPAPPLP 544
G+PP P P P +P PPP P PPLP PPPPPLP PP PPLP
Sbjct: 1150 GIPP-------PPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLP 1202
Query: 545 GA 546
GA
Sbjct: 1203 GA 1204
Score = 49.3 bits (116), Expect = 2e-05
Identities = 30/62 (48%), Positives = 32/62 (51%), Gaps = 19/62 (30%)
Query: 497 GMPPSDLDLLAPAPPPEEVLPLPPP-------PAPPLP----PPPPPLPDK-CPPAPPLP 544
G+PP P P P +P PPP P PPLP PPPPPLP PP PPLP
Sbjct: 1106 GIPP-------PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLP 1158
Query: 545 GA 546
GA
Sbjct: 1159 GA 1160
Score = 48.9 bits (115), Expect = 2e-05
Identities = 27/54 (50%), Positives = 30/54 (55%), Gaps = 5/54 (9%)
Query: 497 GMPPSDLDLLAPAPPPEEVLPLPPPPAPPLP----PPPPPLPDK-CPPAPPLPG 545
G+PP A PPP + + PP PPLP PPPPPLP PP PPLPG
Sbjct: 1128 GIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1181
Score = 47.4 bits (111), Expect = 7e-05
Identities = 30/63 (47%), Positives = 32/63 (50%), Gaps = 21/63 (33%)
Query: 497 GMPPSDLDLLAPAPPPEEVLPLPPPPAP----PLP--------PPPPPLPDK-CPPAPPL 543
G+PP P P P +P PPPP P PLP PPPPPLP PP PPL
Sbjct: 941 GIPP-------PPPLPGAAIP-PPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPL 992
Query: 544 PGA 546
PGA
Sbjct: 993 PGA 995
Score = 45.1 bits (105), Expect = 4e-04
Identities = 25/52 (48%), Positives = 27/52 (51%), Gaps = 14/52 (26%)
Query: 508 PAPPPEEVLPLPPPP------APPLP-------PPPPPLPD-KCPPAPPLPG 545
P PPP + +PPPP PP P PPPPPLP PP PPLPG
Sbjct: 1141 PPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPG 1192
Score = 44.7 bits (104), Expect = 5e-04
Identities = 25/52 (48%), Positives = 26/52 (50%), Gaps = 14/52 (26%)
Query: 508 PAPPPEEVLPLPPPP------APPLP-------PPPPPLPDK-CPPAPPLPG 545
P PPP +PPPP PP P PPPPPLP PP PPLPG
Sbjct: 1053 PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1104
Score = 43.1 bits (100), Expect = 0.001
Identities = 24/51 (47%), Positives = 26/51 (50%), Gaps = 14/51 (27%)
Query: 508 PAPPPEEVLPLPPPP------APPLP-------PPPPPLPDK-CPPAPPLP 544
P PPP + +PPPP PP P PPPPPLP PP PPLP
Sbjct: 1097 PPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1147
Score = 42.0 bits (97), Expect = 0.003
Identities = 29/60 (48%), Positives = 30/60 (50%), Gaps = 14/60 (23%)
Query: 499 PPSDLDLLAPAPPPEEVLPLPP---PPAPPLP----PPPPPLPDK-CPPAPPL--PGAAP 548
PP L + PPP PLP PP PPLP PPPPPLP PP PPL G P
Sbjct: 1098 PPPPLPGVGIPPPP----PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPP 1153
>gi|118572599 formin homology 2 domain containing 1 [Homo sapiens]
Length = 1164
Score = 107 bits (267), Expect = 6e-23
Identities = 108/457 (23%), Positives = 207/457 (45%), Gaps = 32/457 (7%)
Query: 504 DLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIK- 562
D+ AP+PP + +PPPP PL PPPPP+ PP PPLP AAP SA+ K
Sbjct: 568 DIPAPSPPLPLLSGVPPPP--PL-PPPPPIKGPFPPPPPLPLAAPLPHSVPDSSALPTKR 624
Query: 563 KPIKTKFR-LPVFNWTALKPNQIS--GTVFSELDDEKILEDLDLDKFEELFKTKAQGPAL 619
K +K +R L + + ++ T+++ LD + D + E LF+++A+
Sbjct: 625 KTVKLFWRELKLAGGHGVSASRFGPCATLWASLDPVSV----DTARLEHLFESRAK---- 676
Query: 620 DLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVE 679
+++ SK K + + T+L+ R+ + I L I A+ FD + D +E
Sbjct: 677 EVLPSK-KAGEGRRTMTTVLDPKRSNAINIGLTTL-PPVHVIKAALLNFDEFAVSKDGIE 734
Query: 680 CLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDN 739
L+ +PTE E + + + + P L + F++ + + L R+ AF ++
Sbjct: 735 KLLTMMPTEEERQKIEEAQL-ANPDIPLGPAENFLMTLASIGGLAARLQLWAFKLDYDSM 793
Query: 740 LQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDT 799
+ + L + + + + +L +LA+GN++N S+ GF+L L+ + +
Sbjct: 794 EREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNGSQSS---GFELSYLEKVSEV 850
Query: 800 KSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKEL---GRGME 856
K T R+ +LLH + V + P+ ++ + E+ + + A V E + ++ +L R E
Sbjct: 851 KDTVRRQSLLHHLCSLVLQTRPESSDLYSEIPALTRCAKVDFEQLTENLGQLERRSRAAE 910
Query: 857 LIRRECSIHD-----NSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPP 911
R + H+ + L +FL ++ L+ + ++A + Y G +P+
Sbjct: 911 ESLRSLAKHELAPALRARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYLGYTPQAARE 970
Query: 912 ---SVFFPVFVRFIRSYKEAEQENEARKKQEEVMREK 945
F F Y+ + +++++ RE+
Sbjct: 971 VRIMQFCHTLREFALEYRTCRERVLQQQQKQATYRER 1007
>gi|14249316 hypothetical protein LOC84800 [Homo sapiens]
Length = 234
Score = 85.1 bits (209), Expect = 3e-16
Identities = 46/135 (34%), Positives = 75/135 (55%), Gaps = 2/135 (1%)
Query: 227 CILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVR-GGHEI 285
C+ C+RA+MN + G ++S+ V +++ +L+ N K V ELLAA+C+ GH +
Sbjct: 101 CVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVL 160
Query: 286 ILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQY 345
L A D++K VC + +RF +M D N+ ++V + IN V+ ED+ R L+
Sbjct: 161 TLDALDHYKTVCSQQYRFSIVMNELSGSD-NVPYVVTLLSVINAVILGPEDLRARTQLRN 219
Query: 346 EFTKLGLEEFLQKSR 360
EF L L + L + R
Sbjct: 220 EFIGLQLLDVLARLR 234
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 61.6 bits (148), Expect = 4e-09
Identities = 61/202 (30%), Positives = 87/202 (43%), Gaps = 41/202 (20%)
Query: 386 EDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAELEKQ-LLQREKELESIK--E 442
E E + + E++E L ++ L+ E + R LE+Q L+R++ LE + +
Sbjct: 164 ERMERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLD 223
Query: 443 TYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLE------------SVDSEALARVG 490
+ L RL +E++E +R+ LE E SV++ + +G
Sbjct: 224 RERQERQERERLERLERERQER-ERQEQLEREQLEWERERRISSAAAPASVETPLNSVLG 282
Query: 491 PAELSE---------GMPPSD----LDLLAPAPPPEEVLPLPPPPA--------PPLPPP 529
+ SE PS L LAP PPP PLPP PA PP PPP
Sbjct: 283 DSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPP----PLPPGPAQASVALPPPPGPPP 338
Query: 530 PPPLPDKCPPAPPLPGAAPSVV 551
PPPLP PP PP P P+ V
Sbjct: 339 PPPLPSTGPPPPPPPPPLPNQV 360
Score = 30.4 bits (67), Expect = 8.9
Identities = 15/59 (25%), Positives = 34/59 (57%), Gaps = 1/59 (1%)
Query: 926 KEAEQENEARKKQEEVMREKQL-AQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHR 983
++ E+E + R++QE + R+++L QE + + +R + Q++E + L R + + R
Sbjct: 189 EQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERER 247
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 61.6 bits (148), Expect = 4e-09
Identities = 61/202 (30%), Positives = 87/202 (43%), Gaps = 41/202 (20%)
Query: 386 EDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAELEKQ-LLQREKELESIK--E 442
E E + + E++E L ++ L+ E + R LE+Q L+R++ LE + +
Sbjct: 164 ERMERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLD 223
Query: 443 TYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLE------------SVDSEALARVG 490
+ L RL +E++E +R+ LE E SV++ + +G
Sbjct: 224 RERQERQERERLERLERERQER-ERQEQLEREQLEWERERRISSAAAPASVETPLNSVLG 282
Query: 491 PAELSE---------GMPPSD----LDLLAPAPPPEEVLPLPPPPA--------PPLPPP 529
+ SE PS L LAP PPP PLPP PA PP PPP
Sbjct: 283 DSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPP----PLPPGPAQASVALPPPPGPPP 338
Query: 530 PPPLPDKCPPAPPLPGAAPSVV 551
PPPLP PP PP P P+ V
Sbjct: 339 PPPLPSTGPPPPPPPPPLPNQV 360
Score = 30.4 bits (67), Expect = 8.9
Identities = 15/59 (25%), Positives = 34/59 (57%), Gaps = 1/59 (1%)
Query: 926 KEAEQENEARKKQEEVMREKQL-AQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHR 983
++ E+E + R++QE + R+++L QE + + +R + Q++E + L R + + R
Sbjct: 189 EQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERER 247
>gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Homo
sapiens]
Length = 1188
Score = 59.3 bits (142), Expect = 2e-08
Identities = 70/244 (28%), Positives = 98/244 (40%), Gaps = 36/244 (14%)
Query: 487 ARVGPAELSEGMPPSDLDLLAPAPP-------PEEVLPLPPPPAPPLPPPPPPLPDKCPP 539
++V P E P +L APA P + PPPAPPLPPP PPLP PP
Sbjct: 350 SQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLP---PP 406
Query: 540 APPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKP--------NQISGTVFSE 591
APPLP AAP + A + P + P + ALKP N S
Sbjct: 407 APPLPPAAPPLP-----CAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDW 461
Query: 592 LDD---EKILEDLDL----DKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRA 644
D EK+ +L + E+ F + GP + + K + K TLL A
Sbjct: 462 RDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSL-PA 520
Query: 645 KNL--AITLRKAGRSAEEICRAIHTFDLQT---LPVDFVECLMRFLPTEAEVKLLRQYER 699
K+ + + G S+ A + L + +P D +R + E E +L E+
Sbjct: 521 KDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEK 580
Query: 700 ERQP 703
E +P
Sbjct: 581 EAKP 584
Score = 49.3 bits (116), Expect = 2e-05
Identities = 32/78 (41%), Positives = 36/78 (46%), Gaps = 22/78 (28%)
Query: 491 PAELSEGMPPSDLDLLAP---APPPEEVLPLPPPPAPPLPPPPPPL-------------- 533
P ++SE PP L +P APPP +L PPPP PPPPP L
Sbjct: 151 PQDISE--PPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSI 208
Query: 534 ---PDKCPPAPPLPGAAP 548
PD PPAPPL AP
Sbjct: 209 PTPPDFIPPAPPLAFLAP 226
Score = 47.8 bits (112), Expect = 5e-05
Identities = 31/80 (38%), Positives = 33/80 (41%), Gaps = 27/80 (33%)
Query: 491 PAELSEGMPPSDLDLLAPAPPPEEVLPLPP-----------------------PPAPPL- 526
P+ S PP L LL P PPP P PP PPAPPL
Sbjct: 164 PSPPSTAPPPPPL-LLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLA 222
Query: 527 --PPPPPPLPDKCPPAPPLP 544
PPPPP+P PPAP P
Sbjct: 223 FLAPPPPPVPAPAPPAPASP 242
Score = 43.5 bits (101), Expect = 0.001
Identities = 22/48 (45%), Positives = 24/48 (50%), Gaps = 7/48 (14%)
Query: 499 PPSDLDLLAPAPPPEEVLPLPPPPAPPLPP---PPPPLPDKCPPAPPL 543
PP D+ PP LP PP APP PP PPP P PP PP+
Sbjct: 150 PPQDIS----EPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPV 193
Score = 38.9 bits (89), Expect = 0.025
Identities = 24/59 (40%), Positives = 27/59 (45%), Gaps = 11/59 (18%)
Query: 504 DLLAPAPPPEEVLPLP-----PPPAPPLP------PPPPPLPDKCPPAPPLPGAAPSVV 551
DLL P PPP P PP PLP PPPPPL + PP P + P V+
Sbjct: 136 DLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVL 194
>gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Homo
sapiens]
Length = 1188
Score = 59.3 bits (142), Expect = 2e-08
Identities = 70/244 (28%), Positives = 98/244 (40%), Gaps = 36/244 (14%)
Query: 487 ARVGPAELSEGMPPSDLDLLAPAPP-------PEEVLPLPPPPAPPLPPPPPPLPDKCPP 539
++V P E P +L APA P + PPPAPPLPPP PPLP PP
Sbjct: 350 SQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLP---PP 406
Query: 540 APPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKP--------NQISGTVFSE 591
APPLP AAP + A + P + P + ALKP N S
Sbjct: 407 APPLPPAAPPLP-----CAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDW 461
Query: 592 LDD---EKILEDLDL----DKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRA 644
D EK+ +L + E+ F + GP + + K + K TLL A
Sbjct: 462 RDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSL-PA 520
Query: 645 KNL--AITLRKAGRSAEEICRAIHTFDLQT---LPVDFVECLMRFLPTEAEVKLLRQYER 699
K+ + + G S+ A + L + +P D +R + E E +L E+
Sbjct: 521 KDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEK 580
Query: 700 ERQP 703
E +P
Sbjct: 581 EAKP 584
Score = 49.3 bits (116), Expect = 2e-05
Identities = 32/78 (41%), Positives = 36/78 (46%), Gaps = 22/78 (28%)
Query: 491 PAELSEGMPPSDLDLLAP---APPPEEVLPLPPPPAPPLPPPPPPL-------------- 533
P ++SE PP L +P APPP +L PPPP PPPPP L
Sbjct: 151 PQDISE--PPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSI 208
Query: 534 ---PDKCPPAPPLPGAAP 548
PD PPAPPL AP
Sbjct: 209 PTPPDFIPPAPPLAFLAP 226
Score = 47.8 bits (112), Expect = 5e-05
Identities = 31/80 (38%), Positives = 33/80 (41%), Gaps = 27/80 (33%)
Query: 491 PAELSEGMPPSDLDLLAPAPPPEEVLPLPP-----------------------PPAPPL- 526
P+ S PP L LL P PPP P PP PPAPPL
Sbjct: 164 PSPPSTAPPPPPL-LLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLA 222
Query: 527 --PPPPPPLPDKCPPAPPLP 544
PPPPP+P PPAP P
Sbjct: 223 FLAPPPPPVPAPAPPAPASP 242
Score = 43.5 bits (101), Expect = 0.001
Identities = 22/48 (45%), Positives = 24/48 (50%), Gaps = 7/48 (14%)
Query: 499 PPSDLDLLAPAPPPEEVLPLPPPPAPPLPP---PPPPLPDKCPPAPPL 543
PP D+ PP LP PP APP PP PPP P PP PP+
Sbjct: 150 PPQDIS----EPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPV 193
Score = 38.9 bits (89), Expect = 0.025
Identities = 24/59 (40%), Positives = 27/59 (45%), Gaps = 11/59 (18%)
Query: 504 DLLAPAPPPEEVLPLP-----PPPAPPLP------PPPPPLPDKCPPAPPLPGAAPSVV 551
DLL P PPP P PP PLP PPPPPL + PP P + P V+
Sbjct: 136 DLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVL 194
>gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo
sapiens]
Length = 1188
Score = 59.3 bits (142), Expect = 2e-08
Identities = 70/244 (28%), Positives = 98/244 (40%), Gaps = 36/244 (14%)
Query: 487 ARVGPAELSEGMPPSDLDLLAPAPP-------PEEVLPLPPPPAPPLPPPPPPLPDKCPP 539
++V P E P +L APA P + PPPAPPLPPP PPLP PP
Sbjct: 350 SQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLP---PP 406
Query: 540 APPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKP--------NQISGTVFSE 591
APPLP AAP + A + P + P + ALKP N S
Sbjct: 407 APPLPPAAPPLP-----CAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDW 461
Query: 592 LDD---EKILEDLDL----DKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRA 644
D EK+ +L + E+ F + GP + + K + K TLL A
Sbjct: 462 RDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSL-PA 520
Query: 645 KNL--AITLRKAGRSAEEICRAIHTFDLQT---LPVDFVECLMRFLPTEAEVKLLRQYER 699
K+ + + G S+ A + L + +P D +R + E E +L E+
Sbjct: 521 KDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEK 580
Query: 700 ERQP 703
E +P
Sbjct: 581 EAKP 584
Score = 49.3 bits (116), Expect = 2e-05
Identities = 32/78 (41%), Positives = 36/78 (46%), Gaps = 22/78 (28%)
Query: 491 PAELSEGMPPSDLDLLAP---APPPEEVLPLPPPPAPPLPPPPPPL-------------- 533
P ++SE PP L +P APPP +L PPPP PPPPP L
Sbjct: 151 PQDISE--PPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSI 208
Query: 534 ---PDKCPPAPPLPGAAP 548
PD PPAPPL AP
Sbjct: 209 PTPPDFIPPAPPLAFLAP 226
Score = 47.8 bits (112), Expect = 5e-05
Identities = 31/80 (38%), Positives = 33/80 (41%), Gaps = 27/80 (33%)
Query: 491 PAELSEGMPPSDLDLLAPAPPPEEVLPLPP-----------------------PPAPPL- 526
P+ S PP L LL P PPP P PP PPAPPL
Sbjct: 164 PSPPSTAPPPPPL-LLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLA 222
Query: 527 --PPPPPPLPDKCPPAPPLP 544
PPPPP+P PPAP P
Sbjct: 223 FLAPPPPPVPAPAPPAPASP 242
Score = 43.5 bits (101), Expect = 0.001
Identities = 22/48 (45%), Positives = 24/48 (50%), Gaps = 7/48 (14%)
Query: 499 PPSDLDLLAPAPPPEEVLPLPPPPAPPLPP---PPPPLPDKCPPAPPL 543
PP D+ PP LP PP APP PP PPP P PP PP+
Sbjct: 150 PPQDIS----EPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPV 193
Score = 38.9 bits (89), Expect = 0.025
Identities = 24/59 (40%), Positives = 27/59 (45%), Gaps = 11/59 (18%)
Query: 504 DLLAPAPPPEEVLPLP-----PPPAPPLP------PPPPPLPDKCPPAPPLPGAAPSVV 551
DLL P PPP P PP PLP PPPPPL + PP P + P V+
Sbjct: 136 DLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVL 194
>gi|153792074 proline rich 12 [Homo sapiens]
Length = 2036
Score = 57.8 bits (138), Expect = 5e-08
Identities = 32/68 (47%), Positives = 35/68 (51%), Gaps = 18/68 (26%)
Query: 491 PAELSEGMPPSDLDLLAPAPPPEEVLPLPP---------PPAPPLPPPPPP-LPDKCPPA 540
PA + PP P PPP+ LP PP PP PPLPPPPPP +P PP
Sbjct: 1463 PAPTPQPQPPP------PPPPPQPALPSPPPLVAPTPSSPPPPPLPPPPPPAMPS--PPP 1514
Query: 541 PPLPGAAP 548
PP P AAP
Sbjct: 1515 PPPPAAAP 1522
Score = 53.9 bits (128), Expect = 8e-07
Identities = 29/52 (55%), Positives = 30/52 (57%), Gaps = 2/52 (3%)
Query: 500 PSDLDLLAPAP--PPEEVLPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPS 549
PS L+AP P PP LP PPPPA P PPPPPP APP AAPS
Sbjct: 1483 PSPPPLVAPTPSSPPPPPLPPPPPPAMPSPPPPPPPAAAPLAAPPEEPAAPS 1534
Score = 46.6 bits (109), Expect = 1e-04
Identities = 37/132 (28%), Positives = 50/132 (37%), Gaps = 22/132 (16%)
Query: 441 KETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRG-LESVDSEALARVGPAELSEGMP 499
K E + TL ++E++ + L+ ++ + ++D LA +G P
Sbjct: 1364 KRLDEELKRNLETLPSFSSDEEDSVAKNRDLQESISSAISALDDPPLAGPKDTSTPDG-P 1422
Query: 500 PSDLDLLAPAPPP------------------EEVLPLPPPPAPPLPPPPPPLPDKCPPAP 541
P P PPP EE P PPPAP P PPP P PP P
Sbjct: 1423 PLAPAAAVPGPPPLPGLPSANSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPPP--PPQP 1480
Query: 542 PLPGAAPSVVLT 553
LP P V T
Sbjct: 1481 ALPSPPPLVAPT 1492
Score = 45.8 bits (107), Expect = 2e-04
Identities = 28/68 (41%), Positives = 30/68 (44%), Gaps = 11/68 (16%)
Query: 491 PAELSEGMP-PSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPD---------KCPPA 540
P+ S G P P L+ P PP P P PP PP PPP P LP PP
Sbjct: 1440 PSANSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPP-PPPQPALPSPPPLVAPTPSSPPP 1498
Query: 541 PPLPGAAP 548
PPLP P
Sbjct: 1499 PPLPPPPP 1506
Score = 36.2 bits (82), Expect = 0.16
Identities = 25/63 (39%), Positives = 25/63 (39%), Gaps = 9/63 (14%)
Query: 489 VGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAP---PLPPPPPPLPDKCPPAPPLPG 545
V P S PP L P PPP P PPPP P PL PP P P LP
Sbjct: 1489 VAPTPSSPPPPP-----LPPPPPPAMPSP-PPPPPPAAAPLAAPPEEPAAPSPEDPELPD 1542
Query: 546 AAP 548
P
Sbjct: 1543 TRP 1545
Score = 35.0 bits (79), Expect = 0.36
Identities = 30/103 (29%), Positives = 37/103 (35%), Gaps = 28/103 (27%)
Query: 473 PNVRGLESVDSEALARVGPAELSEGMPPSDLDLL------APAPPPE------------- 513
P + + L G +L +PP LL AP+P P
Sbjct: 769 PTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVGVHLLEPAT 828
Query: 514 -EVLPLPPPPAPPLPPPPPPLPDKC-------PPAPPLPGAAP 548
+ P PPPP PP PPPP PL + PA P P P
Sbjct: 829 RDGAPQPPPP-PPPPPPPMPLQLEAHLRSHGLEPAAPSPRLRP 870
Score = 35.0 bits (79), Expect = 0.36
Identities = 25/79 (31%), Positives = 34/79 (43%), Gaps = 6/79 (7%)
Query: 490 GPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPS 549
GP G+ P+ L E + + P PPPPPP PP PP P + P
Sbjct: 1002 GPETPGLGLDPNKPPELPSTVNAEPLGLIQSGPHQAAPPPPPP-----PPPPPAPASEPK 1056
Query: 550 VVLTVGL-SAIRIKKPIKT 567
LT + + + KK +KT
Sbjct: 1057 GGLTSPIFCSTKPKKLLKT 1075
Score = 33.9 bits (76), Expect = 0.81
Identities = 26/86 (30%), Positives = 31/86 (36%), Gaps = 37/86 (43%)
Query: 491 PAELSEGMPPSDLDLLAPAPPPEEVLPLPPPP----------AP---------------- 524
P ++ P+ LL A P+ L LPPPP AP
Sbjct: 767 PPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVGVHLLEP 826
Query: 525 ------PLPPPPPPLPDKCPPAPPLP 544
P PPPPPP PP PP+P
Sbjct: 827 ATRDGAPQPPPPPP-----PPPPPMP 847
Score = 31.2 bits (69), Expect = 5.2
Identities = 15/39 (38%), Positives = 17/39 (43%), Gaps = 3/39 (7%)
Query: 509 APPPEEVLPLPPPPAP---PLPPPPPPLPDKCPPAPPLP 544
APPP+ P P P P PP P+ P PP P
Sbjct: 1691 APPPKAPAPPPKPETPEKTTSEKPPEQTPETAMPEPPAP 1729
Score = 30.8 bits (68), Expect = 6.8
Identities = 15/36 (41%), Positives = 17/36 (47%), Gaps = 6/36 (16%)
Query: 507 APAPPPEEVLP------LPPPPAPPLPPPPPPLPDK 536
APAPPP+ P PP P P PP P+K
Sbjct: 1696 APAPPPKPETPEKTTSEKPPEQTPETAMPEPPAPEK 1731
Score = 30.4 bits (67), Expect = 8.9
Identities = 13/33 (39%), Positives = 15/33 (45%), Gaps = 1/33 (3%)
Query: 520 PPPAPPLPPPPPPLPDKCPPAPPLPGAAPSVVL 552
PPP P PPP P P+K P P P +
Sbjct: 1692 PPPKAPAPPPKPETPEKTTSEKP-PEQTPETAM 1723
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 57.0 bits (136), Expect = 9e-08
Identities = 30/64 (46%), Positives = 32/64 (50%), Gaps = 5/64 (7%)
Query: 491 PAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPSV 550
PA+ S LD+ A PPP PPPP PP PPPPPP P PP P P P
Sbjct: 2387 PAKPRPFFRSSSLDISAQPPPPP-----PPPPPPPPPPPPPPPPPLPPPTSPKPTILPKK 2441
Query: 551 VLTV 554
LTV
Sbjct: 2442 KLTV 2445
Score = 45.1 bits (105), Expect = 4e-04
Identities = 19/47 (40%), Positives = 23/47 (48%)
Query: 521 PPAPPLPPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKT 567
PP PP PPPPPP P PP PPLP + + + P+ T
Sbjct: 2405 PPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTT 2451
Score = 38.9 bits (89), Expect = 0.025
Identities = 24/65 (36%), Positives = 25/65 (38%)
Query: 484 EALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPAPPL 543
E + PA PS L A P L PP PPPPPP P PP PP
Sbjct: 2365 ETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPP 2424
Query: 544 PGAAP 548
P P
Sbjct: 2425 PPLPP 2429
Score = 37.0 bits (84), Expect = 0.096
Identities = 24/60 (40%), Positives = 28/60 (46%), Gaps = 14/60 (23%)
Query: 499 PPSDLDLLAPA-PPPEEVLPLPPPPAPP---LPP--------PPPPLPDKCPPAPPLPGA 546
PPS L PA PPP++ P PPP P PP PPP P P+P PG+
Sbjct: 469 PPSQLP--GPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGS 526
Score = 33.1 bits (74), Expect = 1.4
Identities = 31/101 (30%), Positives = 43/101 (42%), Gaps = 8/101 (7%)
Query: 477 GLESVDSEALARVGPAELSE--GMPPSDLDLLAPAPPPEEVLPLPPPPA--PPLPPPPP- 531
G E SE + GP L++ G+ + PA PP + + P P A P L P
Sbjct: 377 GSEKPSSE---QPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKA 433
Query: 532 PLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLP 572
P P K P P PG P+ G ++ + P K +LP
Sbjct: 434 PGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLP 474
Score = 31.2 bits (69), Expect = 5.2
Identities = 16/42 (38%), Positives = 18/42 (42%), Gaps = 6/42 (14%)
Query: 508 PAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPS 549
P PP ++ P P PPP P P K PP P PS
Sbjct: 466 PTKPPSQL------PGPAKPPPQQPGPAKPPPQQPGSAKPPS 501
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 57.0 bits (136), Expect = 9e-08
Identities = 30/64 (46%), Positives = 32/64 (50%), Gaps = 5/64 (7%)
Query: 491 PAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPSV 550
PA+ S LD+ A PPP PPPP PP PPPPPP P PP P P P
Sbjct: 2387 PAKPRPFFRSSSLDISAQPPPPP-----PPPPPPPPPPPPPPPPPLPPPTSPKPTILPKK 2441
Query: 551 VLTV 554
LTV
Sbjct: 2442 KLTV 2445
Score = 45.1 bits (105), Expect = 4e-04
Identities = 19/47 (40%), Positives = 23/47 (48%)
Query: 521 PPAPPLPPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKT 567
PP PP PPPPPP P PP PPLP + + + P+ T
Sbjct: 2405 PPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTT 2451
Score = 38.9 bits (89), Expect = 0.025
Identities = 24/65 (36%), Positives = 25/65 (38%)
Query: 484 EALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPAPPL 543
E + PA PS L A P L PP PPPPPP P PP PP
Sbjct: 2365 ETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPP 2424
Query: 544 PGAAP 548
P P
Sbjct: 2425 PPLPP 2429
Score = 37.0 bits (84), Expect = 0.096
Identities = 24/60 (40%), Positives = 28/60 (46%), Gaps = 14/60 (23%)
Query: 499 PPSDLDLLAPA-PPPEEVLPLPPPPAPP---LPP--------PPPPLPDKCPPAPPLPGA 546
PPS L PA PPP++ P PPP P PP PPP P P+P PG+
Sbjct: 469 PPSQLP--GPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGS 526
Score = 33.1 bits (74), Expect = 1.4
Identities = 31/101 (30%), Positives = 43/101 (42%), Gaps = 8/101 (7%)
Query: 477 GLESVDSEALARVGPAELSE--GMPPSDLDLLAPAPPPEEVLPLPPPPA--PPLPPPPP- 531
G E SE + GP L++ G+ + PA PP + + P P A P L P
Sbjct: 377 GSEKPSSE---QPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKA 433
Query: 532 PLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLP 572
P P K P P PG P+ G ++ + P K +LP
Sbjct: 434 PGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLP 474
Score = 31.2 bits (69), Expect = 5.2
Identities = 16/42 (38%), Positives = 18/42 (42%), Gaps = 6/42 (14%)
Query: 508 PAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPS 549
P PP ++ P P PPP P P K PP P PS
Sbjct: 466 PTKPPSQL------PGPAKPPPQQPGPAKPPPQQPGSAKPPS 501
>gi|187761324 shootin1 isoform a [Homo sapiens]
Length = 631
Score = 57.0 bits (136), Expect = 9e-08
Identities = 46/175 (26%), Positives = 81/175 (46%), Gaps = 26/175 (14%)
Query: 363 ESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMR 422
E E++QV ++ D ++ + L++ L S ++LL +EN
Sbjct: 213 EYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKL 272
Query: 423 VAELEKQLLQREKELESIKETYEN-TSH-QVHTLRR----LIKEKEEAFQRRCHLEPNVR 476
+LE++ +Q +++++ ++E EN T H ++H L++ L ++K+E + + E R
Sbjct: 273 TQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKAR 332
Query: 477 GLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPP 531
L+ E RV +E S +P PPPP PPLPPPPP
Sbjct: 333 NLKHSVDELQKRVNQSENS--------------------VPPPPPPPPPLPPPPP 367
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,491,750
Number of Sequences: 37866
Number of extensions: 2339798
Number of successful extensions: 61366
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 850
Number of HSP's successfully gapped in prelim test: 1024
Number of HSP's that attempted gapping in prelim test: 24408
Number of HSP's gapped (non-prelim): 19350
length of query: 1027
length of database: 18,247,518
effective HSP length: 112
effective length of query: 915
effective length of database: 14,006,526
effective search space: 12815971290
effective search space used: 12815971290
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.