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Search of human proteins with 119120861
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|119120861 formin-like 3 isoform 2 [Homo sapiens]
(976 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|119120861 formin-like 3 isoform 2 [Homo sapiens] 1939 0.0
gi|119120874 formin-like 3 isoform 1 [Homo sapiens] 1915 0.0
gi|52485606 formin-like 2 [Homo sapiens] 1346 0.0
gi|33356148 formin-like 1 [Homo sapiens] 1065 0.0
gi|40548415 dishevelled associated activator of morphogenesis 2 ... 356 7e-98
gi|21071077 dishevelled-associated activator of morphogenesis 1 ... 326 7e-89
gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens] 303 4e-82
gi|6382071 diaphanous 2 isoform 12C [Homo sapiens] 271 3e-72
gi|5803003 diaphanous 2 isoform 156 [Homo sapiens] 271 3e-72
gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens] 263 8e-70
gi|149999378 inverted formin 2 isoform 2 [Homo sapiens] 214 2e-55
gi|149999380 inverted formin 2 isoform 1 [Homo sapiens] 214 2e-55
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens] 191 2e-48
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens] 191 2e-48
gi|145309324 FH2 domain containing 1 [Homo sapiens] 166 1e-40
gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2) int... 144 4e-34
gi|157168329 formin 1 [Homo sapiens] 138 2e-32
gi|58331242 formin homology 2 domain containing 3 [Homo sapiens] 116 9e-26
gi|160707881 formin 2 [Homo sapiens] 112 1e-24
gi|118572599 formin homology 2 domain containing 1 [Homo sapiens] 107 5e-23
gi|14249316 hypothetical protein LOC84800 [Homo sapiens] 94 6e-19
gi|56549694 enabled homolog isoform a [Homo sapiens] 62 3e-09
gi|39930375 enabled homolog isoform b [Homo sapiens] 62 3e-09
gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Hom... 59 2e-08
gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Hom... 59 2e-08
gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo sap... 59 2e-08
gi|153792074 proline rich 12 [Homo sapiens] 58 5e-08
gi|150170670 piccolo isoform 2 [Homo sapiens] 57 8e-08
gi|150378539 piccolo isoform 1 [Homo sapiens] 57 8e-08
gi|187761324 shootin1 isoform a [Homo sapiens] 57 8e-08
>gi|119120861 formin-like 3 isoform 2 [Homo sapiens]
Length = 976
Score = 1939 bits (5023), Expect = 0.0
Identities = 976/976 (100%), Positives = 976/976 (100%)
Query: 1 MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDN 60
MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDN
Sbjct: 1 MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDN 60
Query: 61 EKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTN 120
EKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTN
Sbjct: 61 EKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTN 120
Query: 121 HIGWVREFLNDENKGLDVLVDYLSFAQCSVMYSTLPGRRALKNSRLVSQKDDVHVCILCL 180
HIGWVREFLNDENKGLDVLVDYLSFAQCSVMYSTLPGRRALKNSRLVSQKDDVHVCILCL
Sbjct: 121 HIGWVREFLNDENKGLDVLVDYLSFAQCSVMYSTLPGRRALKNSRLVSQKDDVHVCILCL 180
Query: 181 RAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFD 240
RAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFD
Sbjct: 181 RAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFD 240
Query: 241 NFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLG 300
NFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLG
Sbjct: 241 NFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLG 300
Query: 301 LEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEK 360
LEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEK
Sbjct: 301 LEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEK 360
Query: 361 LLDLENENMMRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHL 420
LLDLENENMMRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHL
Sbjct: 361 LLDLENENMMRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHL 420
Query: 421 EPNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPP 480
EPNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPP
Sbjct: 421 EPNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPP 480
Query: 481 PLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSE 540
PLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSE
Sbjct: 481 PLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSE 540
Query: 541 LDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITL 600
LDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITL
Sbjct: 541 LDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITL 600
Query: 601 RKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAED 660
RKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAED
Sbjct: 601 RKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAED 660
Query: 661 RFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIIL 720
RFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIIL
Sbjct: 661 RFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIIL 720
Query: 721 ALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELH 780
ALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELH
Sbjct: 721 ALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELH 780
Query: 781 FVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTA 840
FVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTA
Sbjct: 781 FVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTA 840
Query: 841 EEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEA 900
EEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEA
Sbjct: 841 EEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEA 900
Query: 901 KKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITGLHCQPMVVRHQA 960
KKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITGLHCQPMVVRHQA
Sbjct: 901 KKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITGLHCQPMVVRHQA 960
Query: 961 RSAAPPSGPPRAPGPH 976
RSAAPPSGPPRAPGPH
Sbjct: 961 RSAAPPSGPPRAPGPH 976
>gi|119120874 formin-like 3 isoform 1 [Homo sapiens]
Length = 1027
Score = 1915 bits (4961), Expect = 0.0
Identities = 976/1027 (95%), Positives = 976/1027 (95%), Gaps = 51/1027 (4%)
Query: 1 MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDN 60
MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDN
Sbjct: 1 MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDN 60
Query: 61 EKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTN 120
EKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTN
Sbjct: 61 EKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTN 120
Query: 121 HIGWVREFLNDENKGLDVLVDYLSFAQCSVM----------------------------- 151
HIGWVREFLNDENKGLDVLVDYLSFAQCSVM
Sbjct: 121 HIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQP 180
Query: 152 ----------------------YSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYG 189
YSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYG
Sbjct: 181 PSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYG 240
Query: 190 FNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKEL 249
FNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKEL
Sbjct: 241 FNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKEL 300
Query: 250 HRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSR 309
HRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSR
Sbjct: 301 HRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSR 360
Query: 310 HTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENM 369
HTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENM
Sbjct: 361 HTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENM 420
Query: 370 MRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLES 429
MRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLES
Sbjct: 421 MRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLES 480
Query: 430 VDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPA 489
VDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPA
Sbjct: 481 VDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPA 540
Query: 490 PPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILED 549
PPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILED
Sbjct: 541 PPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILED 600
Query: 550 LDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEE 609
LDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEE
Sbjct: 601 LDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEE 660
Query: 610 ICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKV 669
ICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKV
Sbjct: 661 ICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKV 720
Query: 670 ERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSS 729
ERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSS
Sbjct: 721 ERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSS 780
Query: 730 KRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS 789
KRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS
Sbjct: 781 KRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS 840
Query: 790 LENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVR 849
LENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVR
Sbjct: 841 LENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVR 900
Query: 850 YFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPS 909
YFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPS
Sbjct: 901 YFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPS 960
Query: 910 QRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITGLHCQPMVVRHQARSAAPPSGP 969
QRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITGLHCQPMVVRHQARSAAPPSGP
Sbjct: 961 QRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITGLHCQPMVVRHQARSAAPPSGP 1020
Query: 970 PRAPGPH 976
PRAPGPH
Sbjct: 1021 PRAPGPH 1027
>gi|52485606 formin-like 2 [Homo sapiens]
Length = 1092
Score = 1346 bits (3484), Expect = 0.0
Identities = 705/1043 (67%), Positives = 823/1043 (78%), Gaps = 112/1043 (10%)
Query: 23 PGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTY 82
P K+PMPEP ELEERFA+VL++MNLPPDKARLLRQYDNEKKW+LICDQERFQVKNPPHTY
Sbjct: 20 PLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELICDQERFQVKNPPHTY 79
Query: 83 IQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDY 142
IQKL+ +LDP+VTRKKFRRRVQEST+VLRELEISLRTNHIGWVREFLN+ENKGLDVLV+Y
Sbjct: 80 IQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEY 139
Query: 143 LSFAQCSVM--------------------------------------------------- 151
LSFAQ +V
Sbjct: 140 LSFAQYAVTFDFESVESTVESSVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALR 199
Query: 152 YSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKN 211
Y+TLP RR LKNSRLVS+KDDVHVCI+CLRAIMNYQYGFN+VMSHPHAVNEIALSLNNKN
Sbjct: 200 YNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKN 259
Query: 212 PRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVA 271
PRTKALVLELLAAVCLVRGGHEIIL+AFDNFKEVC E RFEKLME+FRNED+NIDFMVA
Sbjct: 260 PRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVA 319
Query: 272 CMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVG 331
MQFINIVVHSVEDMNFRVHLQYEFTKLGL+E+L K +HTES+KLQVQIQAYLDNVFDVG
Sbjct: 320 SMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVG 379
Query: 332 GLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAELEKQLLQREKELESIKE 391
LLEDAETKN ALE+VEELEE++SHL+EKL D ENE M ++ ELEKQL+QR KEL+ ++E
Sbjct: 380 ALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVRE 439
Query: 392 TYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLE----------------------- 428
Y++ + QVHTLR+++KEKEEA QR+ LE + LE
Sbjct: 440 IYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDIAILPVVAS 499
Query: 429 ---SVDSEALA--RVGP---AELSEGMPPSDLDLLAPAPPPEEVL------PLPPPPAPP 474
S+ SE +A VGP A S +PP L + PE V P+PPPP PP
Sbjct: 500 GTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPP 559
Query: 475 LPPPPPPLPDKCPP--------------------APPLPG-AAPSVVLTVGLSAIRIKKP 513
PPPPPP P PP APPLPG ++P+VV GL+A++IKKP
Sbjct: 560 PPPPPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAPPLPGTSSPTVVFNSGLAAVKIKKP 619
Query: 514 IKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICS 573
IKTKFR+PVFNW ALKPNQI+GTVF+E+DDE+ILEDL++D+FEE+FKTKAQGPA+DL S
Sbjct: 620 IKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSS 679
Query: 574 KNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRF 633
K K QK ++KVTLLEANRAKNLAITLRKAG++A+EIC+AIH FDL+TLPVDFVECLMRF
Sbjct: 680 KQKIPQKGSNKVTLLEANRAKNLAITLRKAGKTADEICKAIHVFDLKTLPVDFVECLMRF 739
Query: 634 LPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLT 693
LPTE EVK+LR YERER+PLE L+ EDRFM+ FSK+ERL Q+M MAF+GNF +++QMLT
Sbjct: 740 LPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLMQKMTIMAFIGNFAESIQMLT 799
Query: 694 PQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDR 753
PQL+AIIAAS S+KSSQKLK++LEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDR
Sbjct: 800 PQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDR 859
Query: 754 KMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSI 813
K TLLH+I+ VKEKY ++ F++ELH+VEKAAAVSLENVLLDVKEL RGM+L +RE ++
Sbjct: 860 KQTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTM 919
Query: 814 HD-NSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIR 872
HD N++L+ F+ NEGKL KLQ DAK A++A++ VV+YFGE+PKTTPPSVFFPVFVRF++
Sbjct: 920 HDHNTLLKEFILNNEGKLKKLQDDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVK 979
Query: 873 SYKEAEQENEARKKQEEVMREKQLAQEA--KKLDAKTPSQRNKWQQQELIAELRRRQAKE 930
+YK+AE+ENE RKKQE+ + EK L QEA ++ D K+PS ++K QQQELIAELRRRQ K+
Sbjct: 980 AYKQAEEENELRKKQEQALMEKLLEQEALMEQQDPKSPSHKSKRQQQELIAELRRRQVKD 1039
Query: 931 HRPVYEGKDGTIEDIITGLHCQP 953
+R VYEGKDG IEDIIT L QP
Sbjct: 1040 NRHVYEGKDGAIEDIITDLRNQP 1062
>gi|33356148 formin-like 1 [Homo sapiens]
Length = 1100
Score = 1065 bits (2754), Expect = 0.0
Identities = 599/1092 (54%), Positives = 730/1092 (66%), Gaps = 135/1092 (12%)
Query: 1 MGNLESAEGVPGEPPSVPLLLP-PGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYD 59
MGN + P P + P P P K PMP ELEERF L+ MNLPPDK +LL QYD
Sbjct: 1 MGNAAGSAEQPAGPAAPPPKQPAPPKQPMPAAGELEERFNRALNCMNLPPDKVQLLSQYD 60
Query: 60 NEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKK----------FRRRVQESTKV 109
NEKKW+LICDQERFQVKNPP YIQKL+S++D +K F+RRVQEST+V
Sbjct: 61 NEKKWELICDQERFQVKNPPAAYIQKLKSYVDTGGVSRKVAADWMSNLGFKRRVQESTQV 120
Query: 110 LRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMY----------------- 152
LRELE SLRTNHIGWV+EFLN+EN+GLDVL++YL+FAQCSV Y
Sbjct: 121 LRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVTYDMESTDNGASNSEKNKP 180
Query: 153 -------------STLP-------------GRRALKNSRLVSQKDDVHVCILCLRAIMNY 186
S++P R+AL+NSR+VSQKDDVHVCI+CLRAIMNY
Sbjct: 181 LEQSVEDLSKGPPSSVPKSRHLTIKLTPAHSRKALRNSRIVSQKDDVHVCIMCLRAIMNY 240
Query: 187 QYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVC 246
Q GF+LVM+HP VNEIALSLNNKNPRTKALVLELLAAVCLVRGGH+IILAAFDNFKEVC
Sbjct: 241 QSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHDIILAAFDNFKEVC 300
Query: 247 KELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQ 306
E HRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVE+MNFRV LQYEFT LGL+ +L+
Sbjct: 301 GEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLGLDLYLE 360
Query: 307 KSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLEN 366
+ R TES+KLQVQIQAYLDN+FDVG LLED ETKN LE +EEL+E V+ LTE+L D EN
Sbjct: 361 RLRLTESDKLQVQIQAYLDNIFDVGALLEDTETKNAVLEHMEELQEQVALLTERLRDAEN 420
Query: 367 ENMMRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEK--EEAFQRRCHLEPNV 424
E+M ++AELEKQL Q KELE+++E + ++ + R EK A R LE V
Sbjct: 421 ESMAKIAELEKQLSQARKELETLRERFSESTAMGASRRPPEPEKAPPAAPTRPSALELKV 480
Query: 425 RGLESVDSEALARV--GPAE-----------------------LSEGMPPSDLDLLA--- 456
E ++ + L R+ GP + + G P DL A
Sbjct: 481 ---EELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPA 537
Query: 457 -----PAPPPEEVLPLP-------------------PPPAPPLP---PPPP--------- 480
P PPP LP P PPPAPPLP PPPP
Sbjct: 538 PGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGT 597
Query: 481 --PLPDKCPPAPPLPGAAPSVV----LTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQIS 534
P+P PP PP PG P + +G ++ KKPI+TKFR+P+ NW ALKP+QI+
Sbjct: 598 DGPVPPPPPPPPPPPGGPPDALGRRDSELG-PGVKAKKPIQTKFRMPLLNWVALKPSQIT 656
Query: 535 GTVFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAK 594
GTVF+EL+DEK+L++LD+ FEE FKTK+QGP+LDL K+K AQKA SK TL+EANRAK
Sbjct: 657 GTVFTELNDEKVLQELDMSDFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEANRAK 716
Query: 595 NLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLE 654
NLAITLRK AE IC+AI +DLQ L +DF+E LMRFLPTE E L+ ++ERE++P+E
Sbjct: 717 NLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPME 776
Query: 655 ELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQ 714
EL+ EDRFML FS++ RL +RM + FLGNF D Q+L PQLNAIIAAS S+KSS KL+Q
Sbjct: 777 ELSEEDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQ 836
Query: 715 MLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLAN 774
+LEI+LA GNYMNSSKRGA YGF+LQSLD LL+ KSTDRK TLLH++ + EKYP L
Sbjct: 837 ILEIVLAFGNYMNSSKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTG 896
Query: 775 FWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDN-SVLRNFLSTNEGKLDKL 833
F +LHF++KA +VSL++VL DV+ L RG+EL +RE D+ VL+ FL N +DKL
Sbjct: 897 FHSDLHFLDKAGSVSLDSVLADVRSLQRGLELTQREFVRQDDCMVLKEFLRANSPTMDKL 956
Query: 834 QRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMRE 893
D+KTA+EA+ +VV YFGE+PKTT P +FF +F RFI++YK+AEQE E KK E +
Sbjct: 957 LADSKTAQEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQWKK--EAAAQ 1014
Query: 894 KQLAQEAKKLDAKTPSQRNKWQ--QQELIAELRRRQAKEHRPVYEGKDGTIEDIITGLHC 951
+ A K + P K + Q +LI+EL+RRQ KE +DG IEDIIT +
Sbjct: 1015 EAGADTPGKGEPPAPKSPPKARRPQMDLISELKRRQQKEPLIYESDRDGAIEDIITVIKT 1074
Query: 952 QPMVVRHQARSA 963
P R R++
Sbjct: 1075 VPFTARTGKRTS 1086
>gi|40548415 dishevelled associated activator of morphogenesis 2 [Homo
sapiens]
Length = 1067
Score = 356 bits (913), Expect = 7e-98
Identities = 283/1024 (27%), Positives = 483/1024 (47%), Gaps = 167/1024 (16%)
Query: 18 PLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKN 77
PL P+P EL RFA ++ ++L + EKKW + C +++ Q ++
Sbjct: 32 PLQFMEFSSPIPNAEELNIRFAELVDELDLTDKNREAMFALPPEKKWQIYCSKKKEQ-ED 90
Query: 78 P-------PHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLN 130
P P YI ++ S + +V+ +L+ +LRT + +V F+
Sbjct: 91 PNKLATSWPDYYIDRINSMAAMQSLYAFDEEETEMRNQVVEDLKTALRTQPMRFVTRFI- 149
Query: 131 DENKGLDVLVDYLSFAQCSVMYSTLPGRRALKNSRLVSQKDDVHVCIL-CLRAIMNYQYG 189
E +GL L+++L S+ ++T R +H ++ C++A+MN G
Sbjct: 150 -ELEGLTCLLNFLR----SMDHATCESR--------------IHTSLIGCIKALMNNSQG 190
Query: 190 FNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKEL 249
V++ P A++ IA SL +N +TK VLE+L AVCLV GGH+ +L A +++ E
Sbjct: 191 RAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQVYAAER 250
Query: 250 HRFEKLME-------YFRNEDSNIDFMVACMQFINIVVHS---VEDMNFRVHLQYEFTKL 299
RF+ L+ +R+E ++ A M FIN V+++ +++ FR+HL+YEF L
Sbjct: 251 TRFQTLLNELDRSLGRYRDE---VNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLML 307
Query: 300 GLEEFLQKSRHTESEKLQVQIQAY----------LDNVFDV------------------- 330
G++ + K R E+ L + + L FD+
Sbjct: 308 GIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKL 367
Query: 331 ------------------------GGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLEN 366
GG + + + L+++ +E + L LEN
Sbjct: 368 KYTEAYPCLLSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDER--GVDPDLAPLEN 425
Query: 367 ENMMRVAELEKQLLQREKELESIKETYEN-TSHQVHTLRRLIKEKEEAFQRRCHLEPNVR 425
N+ + +L E E++ ++ E + + RL +++ E + E +R
Sbjct: 426 FNVKNIV----NMLINENEVKQWRDQAEKFRKEHMELVSRLERKERECETKTLEKEEMMR 481
Query: 426 GLESV------DSEAL--ARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLP--------P 469
L + +S+ L AR AEL + ++ PPP L L P
Sbjct: 482 TLNKMKDKLARESQELRQARGQVAELVAQLSELSTGPVSSPPPPGGPLTLSSSMTTNDLP 541
Query: 470 PPAPPL------PPPPPPLPDKCPPAPPLPGAAPSVVLTVGLS---------AIRIKKPI 514
PP PPL PPPPPPLP PP P PGA P + + + L +R K+
Sbjct: 542 PPPPPLPFACCPPPPPPPLPPGGPPTP--PGAPPCLGMGLPLPQDPYPSSDVPLRKKRVP 599
Query: 515 KTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDLDLDKFEELFKT-----KAQGPALD 569
+ L FNW L ++ GTV++E+DD ++ LDL+ FE++F K G D
Sbjct: 600 QPSHPLKSFNWVKLNEERVPGTVWNEIDDMQVFRILDLEDFEKMFSAYQRHQKELGSTED 659
Query: 570 LICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQ-TLPVDFVE 628
+ + K ++++++ RA+N I L K S EEI +AI D Q L D +E
Sbjct: 660 IYLASRK-----VKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLE 714
Query: 629 CLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDN 688
L++F+P ++++ LL +++ E +E +A DRF+ S+++ QR+ + F FQ+
Sbjct: 715 QLLKFIPEKSDIDLLEEHKHE---IERMARADRFLYEMSRIDHYQQRLQALFFKKKFQER 771
Query: 689 LQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDT 748
L P++ AI+ AS + S++L+QMLE+ILA+GN+MN +RG YGF++ SL+ + DT
Sbjct: 772 LAEAKPKVEAILLASRELVRSKRLRQMLEVILAIGNFMNKGQRGGAYGFRVASLNKIADT 831
Query: 749 KST-DRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELI 807
KS+ DR ++LLH++ + +++ +PD+ N EL + +AA V+L + +V L RG+ +
Sbjct: 832 KSSIDRNISLLHYLIMILEKHFPDILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLRAV 891
Query: 808 R---------RECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTT 858
RE S V+ +F++ + +L+ A + + + +FGE
Sbjct: 892 EVLEYQRRQVREPSDKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALMHFGEHDSKM 951
Query: 859 PPSVFFPVFVRFIRSYKEAEQENEA--RKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQQ 916
P FF +F F++++ EA Q+ EA R+K+EE R + A K +R +WQ+
Sbjct: 952 QPDEFFGIFDTFLQAFSEARQDLEAMRRRKEEEERRARMEAM------LKEQRERERWQR 1005
Query: 917 QELI 920
Q +
Sbjct: 1006 QRKV 1009
>gi|21071077 dishevelled-associated activator of morphogenesis 1 [Homo
sapiens]
Length = 1078
Score = 326 bits (835), Expect = 7e-89
Identities = 274/1047 (26%), Positives = 480/1047 (45%), Gaps = 174/1047 (16%)
Query: 26 MPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNP-----PH 80
+PMP EL+ F+ ++ ++L + EKKW + C +++ Q +N P
Sbjct: 45 LPMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKKWQIYCSKKKDQEENKGATSWPE 104
Query: 81 TYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLV 140
YI +L S + +E +K + L+ +LRT + +V F++ + GL ++
Sbjct: 105 FYIDQLNSMAARKSLLALEKEEEEERSKTIESLKTALRTKPMRFVTRFIDLD--GLSCIL 162
Query: 141 DYLSFAQCSVMYSTLPGRRALKNSRLVSQKDDVHVCIL-CLRAIMNYQYGFNLVMSHPHA 199
++L ++ Y T R +H ++ C++A+MN G V++H +
Sbjct: 163 NFLK----TMDYETSESR--------------IHTSLIGCIKALMNNSQGRAHVLAHSES 204
Query: 200 VNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELHRFEKLME-- 257
+N IA SL+ +N +TK VLE+L AVCLV GGH+ +L A ++++ E RF+ L+
Sbjct: 205 INVIAQSLSTENIKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQKYASERTRFQTLINDL 264
Query: 258 -----YFRNEDSNIDFMVACMQFINIVVH---SVEDMNFRVHLQYEFTKLGLEEFLQKSR 309
+R+E + A M FIN V+ VE ++FR+HL+YEF LG++ + K R
Sbjct: 265 DKSTGRYRDE---VSLKTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLR 321
Query: 310 HTES----------EKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKV----EELEEHVS 355
E+ E L+ + + F++ + + T+ L + E H
Sbjct: 322 EHENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSATQMFELTRKRLTHSEAYPHFM 381
Query: 356 HLTEKLLDLENENMMRVAE--------LEKQLLQREKELESIKETYENTSHQVHTLRRLI 407
+ L + + + +++ ++Q +K + EN + + + +R L+
Sbjct: 382 SILHHCLQMPYKRSGNTVQYWLLLDRIIQQIVIQNDKGQDPDSTPLENFNIK-NVVRMLV 440
Query: 408 KE------KEEAFQRRCHLEPNVRGLESVDSEALARVGPAE-----LSEGMPPSDLDLLA 456
E KE+A + R + LE + E A+ E L++ + +
Sbjct: 441 NENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKETTE 500
Query: 457 PAPPPEEVLPL----------------PPPPAPPLP--PPPPPLPDKC---PPAPPLPGA 495
++V L P P+P P P P +P PP PPLPG
Sbjct: 501 HKQVKQQVADLTAQLHELSRRAVCASIPGGPSPGAPGGPFPSSVPGSLLPPPPPPPLPGG 560
Query: 496 ----------------------------APSVVLTVGLSAIRIKKPIKTKFRLPVFNWTA 527
P + + L I +P L FNW+
Sbjct: 561 MLPPPPPPLPPGGPPPPPGPPPLGAIMPPPGAPMGLALKKKSIPQPTNA---LKSFNWSK 617
Query: 528 LKPNQISGTVFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKA------ 581
L N++ GTV++E+DD K+ + LDL+ E F A D + N ++A
Sbjct: 618 LPENKLEGTVWTEIDDTKVFKILDLEDLERTF--SAYQRQQDFFVNSNSKQKEADAIDDT 675
Query: 582 ------ASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQ-TLPVDFVECLMRFL 634
++++++ RA+N I L + S +EI RAI T D Q LP D +E L++F+
Sbjct: 676 LSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFV 735
Query: 635 PTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTP 694
P ++++ LL +++ E L+ +A DRF+ S++ QR+ + F F + + + P
Sbjct: 736 PEKSDIDLLEEHKHE---LDRMAKADRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKP 792
Query: 695 QLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKST-DR 753
++ AI + S V S LKQ+LE++LA GNYMN +RG YGFK+ SL+ + DTKS+ D+
Sbjct: 793 KVEAIRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQRGNAYGFKISSLNKIADTKSSIDK 852
Query: 754 KMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSI 813
+TLLH++ V+ KYP + N EL + +AA V++ + ++ L G++ + E
Sbjct: 853 NITLLHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELDKEISTLRSGLKAVETELEY 912
Query: 814 HDN----------SVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVF 863
+ SV+ F++ ++ A++ + V++FGE P F
Sbjct: 913 QKSQPPQPGDKFVSVVSQFITVASFSFSDVEDLLAEAKDLFTKAVKHFGEEAGKIQPDEF 972
Query: 864 FPVFVRFIRSYKEAEQENE-ARKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQQQELIAE 922
F +F +F+++ EA+QENE RKK+EE R +++A+ QR + E
Sbjct: 973 FGIFDQFLQAVSEAKQENENMRKKKEEEERR-------ARMEAQLKEQRER--------E 1017
Query: 923 LRRRQAKEHRPVYEGKDGTIEDIITGL 949
+ R+AKE+ + G +D+++ L
Sbjct: 1018 RKMRKAKEN----SEESGEFDDLVSAL 1040
>gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens]
Length = 1193
Score = 303 bits (777), Expect = 4e-82
Identities = 249/962 (25%), Positives = 453/962 (47%), Gaps = 116/962 (12%)
Query: 33 ELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLQSFLDP 92
EL E F ++ MNL DK LR+ D K +++ + T K + P
Sbjct: 121 ELLELFEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQY----INTASKTGSLKRSRQISP 176
Query: 93 S--VTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSV 150
+ K + L L +SL +N + WV F ++GL +L+D L +
Sbjct: 177 QEFIHELKMGSADERLVTCLESLRVSLTSNPVSWVESF---GHEGLGLLLDILE----KL 229
Query: 151 MYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNK 210
+ + + KN H I CL+A+MN QYG +MS +++ +A +++ +
Sbjct: 230 ISGKIQEKVVKKNQ---------HKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPR 280
Query: 211 NPRTKALVLELLAAVCLVRGGH--EIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDF 268
+P V++LL+AVC+V E +L A + E K++ RF ++E R+ +++
Sbjct: 281 HPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEE-KKIDRFFCIVEGLRH--NSVQL 337
Query: 269 MVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAY----L 324
VACMQ IN +V S +D++FR+H++ EF + GL+E L + +++ L +Q++ +
Sbjct: 338 QVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKNDGLDIQLKVFDEHKE 397
Query: 325 DNVFDVGGLLEDAETK--------NVALEKVEEL--EEHVSHLTEKLLDLENENMMR--- 371
+++F++ LED + N+ V+E E + + + LL + N+ +R
Sbjct: 398 EDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQHLLLIRNDYFIRQQY 457
Query: 372 ---VAELEKQLLQREKELE------------------------SIKETYENTSHQVHTLR 404
+ E Q++ ++ ++E E S
Sbjct: 458 FKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLEEFEEKASE------ 511
Query: 405 RLIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEE- 463
L K+ E+ F + ++ E+ +E A + + G P+D ++ P PP +E
Sbjct: 512 -LYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNI--PLPPSKEG 568
Query: 464 -----VLPLPPP-------PAPPLPPPPPPLPDK-------CPPAPPLP--GAAPSVVLT 502
LP PPP P PP PPPPPPLP PP PPL G S L
Sbjct: 569 GTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLP 628
Query: 503 VGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDLDL-DKFEELFKT 561
+ ++ KK K + + NW ++P++++ F +E E++DL K E F
Sbjct: 629 ILPFGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCC 688
Query: 562 KAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQT 621
+ + + + K+ +K ++ L++ A+NL+I L EEI I D
Sbjct: 689 QQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETR 748
Query: 622 LPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAF 681
L ++ L++ LP + ++ L Q++ E L ++F+++ S V+RL R++ + F
Sbjct: 749 LAESMIQNLIKHLPDQEQLNSLSQFKSE---YSNLCEPEQFVVVMSNVKRLRPRLSAILF 805
Query: 682 LGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGA-VYGFKLQ 740
F++ + + P + A+ A +K S+ ++LE++L +GNYMN+ R A +GF L
Sbjct: 806 KLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLS 865
Query: 741 SLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKEL 800
SL L DTKS D+K TLLHF+ +EKYPD+ NF +L ++KA+ VS+E + +++++
Sbjct: 866 SLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQM 925
Query: 801 GRGMELIRREC-------SIHDNSV--LRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYF 851
GR ++ + +E +HD V + F+ + + + + L + + E+ Y +++ Y+
Sbjct: 926 GRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIGYY 985
Query: 852 GESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQR 911
K F F ++ +A +EN +++ EE + ++A+E + + Q+
Sbjct: 986 AIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQQK 1045
Query: 912 NK 913
K
Sbjct: 1046 KK 1047
>gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]
Length = 1096
Score = 271 bits (692), Expect = 3e-72
Identities = 254/975 (26%), Positives = 428/975 (43%), Gaps = 129/975 (13%)
Query: 33 ELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQ-----ERFQVKNPPHTYIQKLQ 87
E+ + F ++ MNL +K LR D K +++ + +KN H Q
Sbjct: 105 EVLDLFEKMMEDMNLNEEKKAPLRNKDFTTKREMVVQYISATAKSGGLKNSKHECTLSSQ 164
Query: 88 SFLDPSVTRKKFRRRVQESTKV--LRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSF 145
++ + R + + + L L +SL +N + WV F ++GL +L+D L
Sbjct: 165 EYVH------ELRSGISDEKLLNCLESLRVSLTSNPVSWVNNF---GHEGLGLLLDELE- 214
Query: 146 AQCSVMYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIAL 205
L ++ +N K + + I CL+A MN ++G ++ ++ +A
Sbjct: 215 --------KLLDKKQQENI----DKKNQYKLIQCLKAFMNNKFGLQRILGDERSLLLLAR 262
Query: 206 SLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELH---RFEKLMEYFRNE 262
+++ K P ++++L+A+C+V G E IL E + RF ++E N+
Sbjct: 263 AIDPKQPNMMTEIVKILSAICIV--GEENILDKLLGAITTAAERNNRERFSPIVEGLENQ 320
Query: 263 DSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQA 322
++ + VACMQFIN +V S +++FR+HL+ EF + GL+ L + E+++L +Q++
Sbjct: 321 EA-LQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKTMLPDLKEKENDELDIQLKV 379
Query: 323 YLDNVFD-------------------------VGGLLEDAETKNVALEKVEE-------- 349
+ +N D + +L+D +N L ++
Sbjct: 380 FDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTAAENYFLSILQHFLLIRNDY 439
Query: 350 ---------LEEHVSHLT------------EKLLDLENENMM-------RVAELEKQLLQ 381
+EE VS + + LD++ +++ +V E E++ +
Sbjct: 440 YIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTHLIDSCVNKAKVEESEQKAAE 499
Query: 382 REKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGPA 441
K+ + + ++ IKE E Q+ L + L S P
Sbjct: 500 FSKKFDEEFTARQEAQAELQKRDEKIKELEAEIQQ---LRTQAQVLSSSSGIPGPPAAPP 556
Query: 442 ELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAP-------PLPPPPPPLPDKCPPAPPLPG 494
G PP PAPP PLPPPP P P PPPPP L PP PPL G
Sbjct: 557 LPGVGPPPPP-----PAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLGG 611
Query: 495 AAPSVVLTVGLS-AIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDLDL- 552
P +++ L ++ KK K + + NW+ ++P ++S F E E+ DL
Sbjct: 612 VPPPPGISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTELSENCFWLRVKEDKFENPDLF 671
Query: 553 DKFEELFKT--KAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEI 610
K F T K Q A L K +K ++ +L+ A+NL+I L E+I
Sbjct: 672 AKLALNFATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDI 731
Query: 611 CRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVE 670
I + L ++ L++ LP E K+L + + ++L ++F ++ S V+
Sbjct: 732 RNVILEVNEDMLSEALIQNLVKHLP---EQKILNELAELKNEYDDLCEPEQFGVVMSSVK 788
Query: 671 RLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSK 730
L R++ + F F++++ + P + A+ A +K S+ ++LE++L +GNYMNS
Sbjct: 789 MLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGS 848
Query: 731 RGA-VYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS 789
R A GFK+ L + DTKS D+K TLLHFIA +EKY D+ F EL VE A+ VS
Sbjct: 849 RNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPEELEHVESASKVS 908
Query: 790 -------LENVLLDVKELGRGMELIRRECSIHDNSV--LRNFLSTNEGKLDKLQRDAKTA 840
L ++ + L R ++ + + HD V + +F T + +KL
Sbjct: 909 AQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEKLSTMHNNM 968
Query: 841 EEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEA 900
+ Y + YF KT FF F + EA +EN R++ EE R +LA+E
Sbjct: 969 MKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKE- 1027
Query: 901 KKLDAKTPSQRNKWQ 915
K K Q+ K Q
Sbjct: 1028 KAEQEKLERQKKKKQ 1042
>gi|5803003 diaphanous 2 isoform 156 [Homo sapiens]
Length = 1101
Score = 271 bits (692), Expect = 3e-72
Identities = 254/975 (26%), Positives = 428/975 (43%), Gaps = 129/975 (13%)
Query: 33 ELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQ-----ERFQVKNPPHTYIQKLQ 87
E+ + F ++ MNL +K LR D K +++ + +KN H Q
Sbjct: 105 EVLDLFEKMMEDMNLNEEKKAPLRNKDFTTKREMVVQYISATAKSGGLKNSKHECTLSSQ 164
Query: 88 SFLDPSVTRKKFRRRVQESTKV--LRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSF 145
++ + R + + + L L +SL +N + WV F ++GL +L+D L
Sbjct: 165 EYVH------ELRSGISDEKLLNCLESLRVSLTSNPVSWVNNF---GHEGLGLLLDELE- 214
Query: 146 AQCSVMYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIAL 205
L ++ +N K + + I CL+A MN ++G ++ ++ +A
Sbjct: 215 --------KLLDKKQQENI----DKKNQYKLIQCLKAFMNNKFGLQRILGDERSLLLLAR 262
Query: 206 SLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELH---RFEKLMEYFRNE 262
+++ K P ++++L+A+C+V G E IL E + RF ++E N+
Sbjct: 263 AIDPKQPNMMTEIVKILSAICIV--GEENILDKLLGAITTAAERNNRERFSPIVEGLENQ 320
Query: 263 DSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQA 322
++ + VACMQFIN +V S +++FR+HL+ EF + GL+ L + E+++L +Q++
Sbjct: 321 EA-LQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKTMLPDLKEKENDELDIQLKV 379
Query: 323 YLDNVFD-------------------------VGGLLEDAETKNVALEKVEE-------- 349
+ +N D + +L+D +N L ++
Sbjct: 380 FDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTAAENYFLSILQHFLLIRNDY 439
Query: 350 ---------LEEHVSHLT------------EKLLDLENENMM-------RVAELEKQLLQ 381
+EE VS + + LD++ +++ +V E E++ +
Sbjct: 440 YIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTHLIDSCVNKAKVEESEQKAAE 499
Query: 382 REKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGPA 441
K+ + + ++ IKE E Q+ L + L S P
Sbjct: 500 FSKKFDEEFTARQEAQAELQKRDEKIKELEAEIQQ---LRTQAQVLSSSSGIPGPPAAPP 556
Query: 442 ELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAP-------PLPPPPPPLPDKCPPAPPLPG 494
G PP PAPP PLPPPP P P PPPPP L PP PPL G
Sbjct: 557 LPGVGPPPPP-----PAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLGG 611
Query: 495 AAPSVVLTVGLS-AIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDLDL- 552
P +++ L ++ KK K + + NW+ ++P ++S F E E+ DL
Sbjct: 612 VPPPPGISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTELSENCFWLRVKEDKFENPDLF 671
Query: 553 DKFEELFKT--KAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEI 610
K F T K Q A L K +K ++ +L+ A+NL+I L E+I
Sbjct: 672 AKLALNFATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDI 731
Query: 611 CRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVE 670
I + L ++ L++ LP E K+L + + ++L ++F ++ S V+
Sbjct: 732 RNVILEVNEDMLSEALIQNLVKHLP---EQKILNELAELKNEYDDLCEPEQFGVVMSSVK 788
Query: 671 RLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSK 730
L R++ + F F++++ + P + A+ A +K S+ ++LE++L +GNYMNS
Sbjct: 789 MLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGS 848
Query: 731 RGA-VYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS 789
R A GFK+ L + DTKS D+K TLLHFIA +EKY D+ F EL VE A+ VS
Sbjct: 849 RNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPEELEHVESASKVS 908
Query: 790 -------LENVLLDVKELGRGMELIRRECSIHDNSV--LRNFLSTNEGKLDKLQRDAKTA 840
L ++ + L R ++ + + HD V + +F T + +KL
Sbjct: 909 AQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEKLSTMHNNM 968
Query: 841 EEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEA 900
+ Y + YF KT FF F + EA +EN R++ EE R +LA+E
Sbjct: 969 MKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKE- 1027
Query: 901 KKLDAKTPSQRNKWQ 915
K K Q+ K Q
Sbjct: 1028 KAEQEKLERQKKKKQ 1042
>gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens]
Length = 849
Score = 263 bits (671), Expect = 8e-70
Identities = 207/799 (25%), Positives = 387/799 (48%), Gaps = 94/799 (11%)
Query: 194 MSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGH--EIILAAFDNFKEVCKELHR 251
MS +++ +A +++ ++P V++LL+AVC+V E +L A + E K++ R
Sbjct: 1 MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEE-KKIDR 59
Query: 252 FEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHT 311
F ++E R+ +++ VACMQ IN +V S +D++FR+H++ EF + GL+E L +
Sbjct: 60 FFCIVEGLRH--NSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCI 117
Query: 312 ESEKLQVQIQAY----LDNVFDVGGLLEDAETK--------NVALEKVEEL--EEHVSHL 357
+++ L +Q++ + +++F++ LED + N+ V+E E + +
Sbjct: 118 KNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISI 177
Query: 358 TEKLLDLENENMMR------VAELEKQLLQREKELE------------------------ 387
+ LL + N+ +R + E Q++ ++
Sbjct: 178 LQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQA 237
Query: 388 SIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGPAELSEGM 447
++E E S L K+ E+ F + ++ E+ +E A + + G
Sbjct: 238 KLEEFEEKASE-------LYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGA 290
Query: 448 PPSDLDLLAPAPPPEE------VLPLPPP-------PAPPLPPPPPPLPDK-------CP 487
P+D ++ P PP +E LP PPP P PP PPPPPPLP P
Sbjct: 291 LPADCNI--PLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVP 348
Query: 488 PAPPLP--GAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEK 545
P PPL G S L + ++ KK K + + NW ++P++++ F +E
Sbjct: 349 PPPPLGFLGGQNSPPLPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNEN 408
Query: 546 ILEDLDL-DKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAG 604
E++DL K E F + + + + K+ +K ++ L++ A+NL+I L
Sbjct: 409 KYENVDLLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFR 468
Query: 605 RSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFML 664
EEI I D L ++ L++ LP + ++ L Q++ E L ++F++
Sbjct: 469 VPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSE---YSNLCEPEQFVV 525
Query: 665 LFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGN 724
+ S V+RL R++ + F F++ + + P + A+ A +K S+ ++LE++L +GN
Sbjct: 526 VMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGN 585
Query: 725 YMNSSKRGA-VYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVE 783
YMN+ R A +GF L SL L DTKS D+K TLLHF+ +EKYPD+ NF +L ++
Sbjct: 586 YMNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLD 645
Query: 784 KAAAVSLENVLLDVKELGRGMELIRREC-------SIHDNSV--LRNFLSTNEGKLDKLQ 834
KA+ VS+E + +++++GR ++ + +E +HD V + F+ + + + + L
Sbjct: 646 KASKVSVETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLS 705
Query: 835 RDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREK 894
+ + E+ Y +++ Y+ K F F ++ +A +EN +++ EE +
Sbjct: 706 KLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRV 765
Query: 895 QLAQEAKKLDAKTPSQRNK 913
++A+E + + Q+ K
Sbjct: 766 RIAKELAERERLERQQKKK 784
>gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]
Length = 1240
Score = 214 bits (546), Expect = 2e-55
Identities = 237/946 (25%), Positives = 396/946 (41%), Gaps = 169/946 (17%)
Query: 123 GWVREFLNDENKGLDVLVDYLSFAQCSVMYSTLPGRRALKNSRLVSQKDDVHVCILCLRA 182
GW+ +FL E GLD+L++ L+ L GR + S + Q C+ C+RA
Sbjct: 63 GWMVQFL--EQSGLDLLLEALA---------RLSGRGVARISDALLQL----TCVSCVRA 107
Query: 183 IMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRG-GHEIILAAFDN 241
+MN + G ++S+ V +++ +L+ N K V ELLAA+C+ GH + L A D+
Sbjct: 108 VMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDH 167
Query: 242 FKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGL 301
+K VC + +RF +M D N+ ++V + IN V+ ED+ R L+ EF L L
Sbjct: 168 YKTVCSQQYRFSIVMNELSGSD-NVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQL 226
Query: 302 EEFLQKSRHTESEKLQVQIQAYLD-------NVFDVGGLLEDAETKNV------------ 342
+ L + R E L +Q++A+ + + V G ++ + + V
Sbjct: 227 LDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLFHKVSCSP 286
Query: 343 -------ALEKVEELEEHVSH---LTEKLLDLENENMMRVAELEKQLLQREKE-LESIKE 391
L+ + LE + L E L L N ++ ++ ++ L+ E L S+K
Sbjct: 287 VSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQECTLEEVVERLLSVKG 346
Query: 392 TYENT----SHQVHTLRRLIKEKEEAFQRRCHLEPNVRG-----------LESVDSEALA 436
+ +H+ ++ + Q +P+V G ++ SE++
Sbjct: 347 RPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESIL 406
Query: 437 RVGPAELSEGM-----PPSDLDLLA------PAPPPEEVLP---------LPPPP----- 471
+V E PP LL P PPP LP PPPP
Sbjct: 407 KVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGL 466
Query: 472 ---APPLPPPPPPLPDKC----PPAPPLPGAA---PSVVLTVGL---------------- 505
APP PP PPPLP C PP PPLPG P L G+
Sbjct: 467 GAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTC 526
Query: 506 --------------------------SAIRIKKPIKTKFRLPVFNWTALKPN--QISGTV 537
S R+ P R+ NW L N + ++
Sbjct: 527 SPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPP---TLRMKKLNWQKLPSNVAREHNSM 583
Query: 538 FSELD--DEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKN 595
++ L D + +E D E LF A P + + A+K ++T L+A ++ N
Sbjct: 584 WASLSSPDAEAVEP-DFSSIERLFSFPAAKPKEPTMVAPR--ARKEPKEITFLDAKKSLN 640
Query: 596 LAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEE 655
L I L++ S EE+ I D V+ ++ L++ LP + E++ LR + ER +
Sbjct: 641 LNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEER---AK 697
Query: 656 LAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQM 715
LA+ D F LL + R+ M L M+ P+ ++AA S+ +S++L
Sbjct: 698 LASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIF 757
Query: 716 LEIILALGNYMN-SSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLAN 774
++IL +GN++N S G GFK+ +L L +TKS ++TLLH + ++ +PDL
Sbjct: 758 CQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQ 817
Query: 775 FWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNF---LSTNEGKLD 831
+L +AA ++LE + + + + R+ S V + L +
Sbjct: 818 LPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTERLQASISAFR 877
Query: 832 KLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQ--EE 889
L + E+ + Y E + F F + A +EN+ RK+Q +
Sbjct: 878 ALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKA 937
Query: 890 VMREKQLAQEAKKL----DAKTPSQRNKWQQQE------LIAELRR 925
R++QLA+E + D K P ++ +Q+E L+A++R+
Sbjct: 938 ERRKQQLAEEEARRPRGEDGK-PVRKGPGKQEEVCVIDALLADIRK 982
>gi|149999380 inverted formin 2 isoform 1 [Homo sapiens]
Length = 1249
Score = 214 bits (546), Expect = 2e-55
Identities = 237/946 (25%), Positives = 396/946 (41%), Gaps = 169/946 (17%)
Query: 123 GWVREFLNDENKGLDVLVDYLSFAQCSVMYSTLPGRRALKNSRLVSQKDDVHVCILCLRA 182
GW+ +FL E GLD+L++ L+ L GR + S + Q C+ C+RA
Sbjct: 63 GWMVQFL--EQSGLDLLLEALA---------RLSGRGVARISDALLQL----TCVSCVRA 107
Query: 183 IMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRG-GHEIILAAFDN 241
+MN + G ++S+ V +++ +L+ N K V ELLAA+C+ GH + L A D+
Sbjct: 108 VMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDH 167
Query: 242 FKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGL 301
+K VC + +RF +M D N+ ++V + IN V+ ED+ R L+ EF L L
Sbjct: 168 YKTVCSQQYRFSIVMNELSGSD-NVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQL 226
Query: 302 EEFLQKSRHTESEKLQVQIQAYLD-------NVFDVGGLLEDAETKNV------------ 342
+ L + R E L +Q++A+ + + V G ++ + + V
Sbjct: 227 LDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLFHKVSCSP 286
Query: 343 -------ALEKVEELEEHVSH---LTEKLLDLENENMMRVAELEKQLLQREKE-LESIKE 391
L+ + LE + L E L L N ++ ++ ++ L+ E L S+K
Sbjct: 287 VSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQECTLEEVVERLLSVKG 346
Query: 392 TYENT----SHQVHTLRRLIKEKEEAFQRRCHLEPNVRG-----------LESVDSEALA 436
+ +H+ ++ + Q +P+V G ++ SE++
Sbjct: 347 RPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESIL 406
Query: 437 RVGPAELSEGM-----PPSDLDLLA------PAPPPEEVLP---------LPPPP----- 471
+V E PP LL P PPP LP PPPP
Sbjct: 407 KVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGL 466
Query: 472 ---APPLPPPPPPLPDKC----PPAPPLPGAA---PSVVLTVGL---------------- 505
APP PP PPPLP C PP PPLPG P L G+
Sbjct: 467 GAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTC 526
Query: 506 --------------------------SAIRIKKPIKTKFRLPVFNWTALKPN--QISGTV 537
S R+ P R+ NW L N + ++
Sbjct: 527 SPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPP---TLRMKKLNWQKLPSNVAREHNSM 583
Query: 538 FSELD--DEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKN 595
++ L D + +E D E LF A P + + A+K ++T L+A ++ N
Sbjct: 584 WASLSSPDAEAVEP-DFSSIERLFSFPAAKPKEPTMVAPR--ARKEPKEITFLDAKKSLN 640
Query: 596 LAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEE 655
L I L++ S EE+ I D V+ ++ L++ LP + E++ LR + ER +
Sbjct: 641 LNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEER---AK 697
Query: 656 LAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQM 715
LA+ D F LL + R+ M L M+ P+ ++AA S+ +S++L
Sbjct: 698 LASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIF 757
Query: 716 LEIILALGNYMN-SSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLAN 774
++IL +GN++N S G GFK+ +L L +TKS ++TLLH + ++ +PDL
Sbjct: 758 CQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQ 817
Query: 775 FWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNF---LSTNEGKLD 831
+L +AA ++LE + + + + R+ S V + L +
Sbjct: 818 LPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTERLQASISAFR 877
Query: 832 KLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQ--EE 889
L + E+ + Y E + F F + A +EN+ RK+Q +
Sbjct: 878 ALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKA 937
Query: 890 VMREKQLAQEAKKL----DAKTPSQRNKWQQQE------LIAELRR 925
R++QLA+E + D K P ++ +Q+E L+A++R+
Sbjct: 938 ERRKQQLAEEEARRPRGEDGK-PVRKGPGKQEEVCVIDALLADIRK 982
>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
Length = 1263
Score = 191 bits (486), Expect = 2e-48
Identities = 151/535 (28%), Positives = 246/535 (45%), Gaps = 63/535 (11%)
Query: 433 EALARVGPAELSEGM---PPSDLDLLAPAPPPEEVLP----LPPPPAP-----PLPPPPP 480
E + P+ L G PP L A PPP LP +PPPP P +PPPPP
Sbjct: 650 EGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPP 709
Query: 481 PLPDK--CPPAPPLPG------------------------AAPSVVLTVGLSAIRIKKPI 514
PLP PP PP PG AAP VL GL+ ++ KP
Sbjct: 710 PLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAP--VLPFGLTPKKLYKP- 766
Query: 515 KTKFRLPVFNWTALKPNQISGTVF------SELDDEKILEDLDLDKFEELFKTKAQGPAL 568
+ + R P NW+ L +S F ++ ++ L L F KT
Sbjct: 767 EVQLRRP--NWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLT-FSAQTKTSKAKKDQ 823
Query: 569 DLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVE 628
+ K +K ++ +L++ A+NL+I L +EI I + L ++
Sbjct: 824 EGGEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQ 883
Query: 629 CLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDN 688
L++ +P ++K+L + + E ++LA ++F ++ V RL R+ + F F +
Sbjct: 884 NLIKQMPEPEQLKMLSELKDE---YDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQ 940
Query: 689 LQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGA-VYGFKLQSLDLLLD 747
++ + P++ ++ AA ++ S+ +LEI L +GNYMN+ R A +GF + L L D
Sbjct: 941 VENIKPEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRD 1000
Query: 748 TKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELI 807
TKSTD+KMTLLHF+A + YPD+ F EL VEKA+ VS EN+ ++ ++ + + +
Sbjct: 1001 TKSTDQKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDV 1060
Query: 808 RRECSIHDNSV---------LRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTT 858
R+ + + +F+ + + +KL+ E Y + YF PK
Sbjct: 1061 ERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKL 1120
Query: 859 PPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNK 913
FF F + +A +EN+ R++ EE MR +LA+E + + Q+ +
Sbjct: 1121 SVEEFFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKRE 1175
Score = 110 bits (274), Expect = 8e-24
Identities = 140/571 (24%), Positives = 225/571 (39%), Gaps = 157/571 (27%)
Query: 38 FALVLSSMNLPPDKARLLRQYDNEKKWDLICD--------QERFQVKNPPHTYIQKLQSF 89
F +L MNL +K + LR+ D K +++ + + YIQ+L+S
Sbjct: 87 FEQMLLDMNLNEEKQQPLREKDIIIKREMVSQYLYTSKAGMSQKESSKSAMMYIQELRSG 146
Query: 90 LDPSVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCS 149
L R L L +SL N + WV+ F +GL L+D L
Sbjct: 147 L-----------RDMPLLSCLESLRVSLNNNPVSWVQTF---GAEGLASLLDILK----- 187
Query: 150 VMYSTLPGRRALKNSRLVSQKDDV---------HVCILCLRAIMNYQYGFNLVMSHPHAV 200
RL +K++ H I CL+A MN ++G ++ +
Sbjct: 188 ---------------RLHDEKEETAGSYDSRNKHEIIRCLKAFMNNKFGIKTMLETEEGI 232
Query: 201 NEIALSLNNKNPRTKALVLELLAAVCLV---RGGHEIILAAFDNFKEVCKELHRFEKLME 257
+ +++ P +LL+A+C++ +E +L A E+ E+ RF+ L++
Sbjct: 233 LLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEM-DEVERFQPLLD 291
Query: 258 YFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQ 317
++ + I V C+Q IN ++ E+++FRVH++ E +LGL + LQ R E+E ++
Sbjct: 292 GLKS-GTTIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQDLREIENEDMR 350
Query: 318 VQIQAY----LDNVFDVGGLLEDA--------ETKNVALEKVEE--LEEHVSHLTEKLLD 363
VQ+ + ++ +D+ G L+D E + L V++ E H + + LL
Sbjct: 351 VQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSILQHLLL 410
Query: 364 LENENMMR---------------------------------------------------- 371
+ N+ R
Sbjct: 411 VRNDYEARPQYYKLIEECISQIVLHKNGADPDFKCRHLQIEIEGLIDQMIDKTKVEKSEA 470
Query: 372 -VAELEKQL---LQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGL 427
AELEK+L L EL+ + E+ Q L+ L EK+ + + + L
Sbjct: 471 KAAELEKKLDSELTARHELQVEMKKMESDFEQ--KLQDLQGEKDALHSEKQQIATEKQDL 528
Query: 428 ESVDSEALARVGP------------AELSEG---MPPSDLDLLAPAPPPEEVLP------ 466
E+ S+ V A LS +PPS + AP PP LP
Sbjct: 529 EAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPS-VPSRAPVPPAPP-LPGDSGTI 586
Query: 467 LPPPPAP---PLPPPPPPLPDKCPPAPPLPG 494
+PPPPAP PPPPPP P PP PPLPG
Sbjct: 587 IPPPPAPGDSTTPPPPPPPP---PPPPPLPG 614
Score = 63.9 bits (154), Expect = 7e-10
Identities = 62/196 (31%), Positives = 88/196 (44%), Gaps = 21/196 (10%)
Query: 307 KSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELE---EHVSHLTEKLLD 363
K RH LQ++I+ +D + D + E +E K LEK + E H + K ++
Sbjct: 444 KCRH-----LQIEIEGLIDQMIDKTKV-EKSEAKAAELEKKLDSELTARHELQVEMKKME 497
Query: 364 LENENMMRVAELEKQLLQREKE-LESIKETYE-NTSHQVHTLRRLIKEKEEAFQRRCHLE 421
+ E ++ + EK L EK+ + + K+ E S + +L KE E+A + L
Sbjct: 498 SDFEQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLS 557
Query: 422 PNVRGLE-SVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPP 480
+ SV S A P P D + P PP PPPP PP PPPPP
Sbjct: 558 AAAITVPPSVPSRAPVPPAPPL------PGDSGTIIPPPPAPGDSTTPPPPPPP-PPPPP 610
Query: 481 PLP-DKCPPAPP-LPG 494
PLP C +PP LPG
Sbjct: 611 PLPGGVCISSPPSLPG 626
>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
Length = 1272
Score = 191 bits (486), Expect = 2e-48
Identities = 151/535 (28%), Positives = 246/535 (45%), Gaps = 63/535 (11%)
Query: 433 EALARVGPAELSEGM---PPSDLDLLAPAPPPEEVLP----LPPPPAP-----PLPPPPP 480
E + P+ L G PP L A PPP LP +PPPP P +PPPPP
Sbjct: 659 EGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPP 718
Query: 481 PLPDK--CPPAPPLPG------------------------AAPSVVLTVGLSAIRIKKPI 514
PLP PP PP PG AAP VL GL+ ++ KP
Sbjct: 719 PLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAP--VLPFGLTPKKLYKP- 775
Query: 515 KTKFRLPVFNWTALKPNQISGTVF------SELDDEKILEDLDLDKFEELFKTKAQGPAL 568
+ + R P NW+ L +S F ++ ++ L L F KT
Sbjct: 776 EVQLRRP--NWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLT-FSAQTKTSKAKKDQ 832
Query: 569 DLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVE 628
+ K +K ++ +L++ A+NL+I L +EI I + L ++
Sbjct: 833 EGGEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQ 892
Query: 629 CLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDN 688
L++ +P ++K+L + + E ++LA ++F ++ V RL R+ + F F +
Sbjct: 893 NLIKQMPEPEQLKMLSELKDE---YDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQ 949
Query: 689 LQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGA-VYGFKLQSLDLLLD 747
++ + P++ ++ AA ++ S+ +LEI L +GNYMN+ R A +GF + L L D
Sbjct: 950 VENIKPEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRD 1009
Query: 748 TKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELI 807
TKSTD+KMTLLHF+A + YPD+ F EL VEKA+ VS EN+ ++ ++ + + +
Sbjct: 1010 TKSTDQKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDV 1069
Query: 808 RRECSIHDNSV---------LRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTT 858
R+ + + +F+ + + +KL+ E Y + YF PK
Sbjct: 1070 ERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKL 1129
Query: 859 PPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNK 913
FF F + +A +EN+ R++ EE MR +LA+E + + Q+ +
Sbjct: 1130 SVEEFFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKRE 1184
Score = 110 bits (274), Expect = 8e-24
Identities = 140/571 (24%), Positives = 225/571 (39%), Gaps = 157/571 (27%)
Query: 38 FALVLSSMNLPPDKARLLRQYDNEKKWDLICD--------QERFQVKNPPHTYIQKLQSF 89
F +L MNL +K + LR+ D K +++ + + YIQ+L+S
Sbjct: 96 FEQMLLDMNLNEEKQQPLREKDIIIKREMVSQYLYTSKAGMSQKESSKSAMMYIQELRSG 155
Query: 90 LDPSVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCS 149
L R L L +SL N + WV+ F +GL L+D L
Sbjct: 156 L-----------RDMPLLSCLESLRVSLNNNPVSWVQTF---GAEGLASLLDILK----- 196
Query: 150 VMYSTLPGRRALKNSRLVSQKDDV---------HVCILCLRAIMNYQYGFNLVMSHPHAV 200
RL +K++ H I CL+A MN ++G ++ +
Sbjct: 197 ---------------RLHDEKEETAGSYDSRNKHEIIRCLKAFMNNKFGIKTMLETEEGI 241
Query: 201 NEIALSLNNKNPRTKALVLELLAAVCLV---RGGHEIILAAFDNFKEVCKELHRFEKLME 257
+ +++ P +LL+A+C++ +E +L A E+ E+ RF+ L++
Sbjct: 242 LLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEM-DEVERFQPLLD 300
Query: 258 YFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQ 317
++ + I V C+Q IN ++ E+++FRVH++ E +LGL + LQ R E+E ++
Sbjct: 301 GLKS-GTTIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQDLREIENEDMR 359
Query: 318 VQIQAY----LDNVFDVGGLLEDA--------ETKNVALEKVEE--LEEHVSHLTEKLLD 363
VQ+ + ++ +D+ G L+D E + L V++ E H + + LL
Sbjct: 360 VQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSILQHLLL 419
Query: 364 LENENMMR---------------------------------------------------- 371
+ N+ R
Sbjct: 420 VRNDYEARPQYYKLIEECISQIVLHKNGADPDFKCRHLQIEIEGLIDQMIDKTKVEKSEA 479
Query: 372 -VAELEKQL---LQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGL 427
AELEK+L L EL+ + E+ Q L+ L EK+ + + + L
Sbjct: 480 KAAELEKKLDSELTARHELQVEMKKMESDFEQ--KLQDLQGEKDALHSEKQQIATEKQDL 537
Query: 428 ESVDSEALARVGP------------AELSEG---MPPSDLDLLAPAPPPEEVLP------ 466
E+ S+ V A LS +PPS + AP PP LP
Sbjct: 538 EAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPS-VPSRAPVPPAPP-LPGDSGTI 595
Query: 467 LPPPPAP---PLPPPPPPLPDKCPPAPPLPG 494
+PPPPAP PPPPPP P PP PPLPG
Sbjct: 596 IPPPPAPGDSTTPPPPPPPP---PPPPPLPG 623
Score = 63.9 bits (154), Expect = 7e-10
Identities = 62/196 (31%), Positives = 88/196 (44%), Gaps = 21/196 (10%)
Query: 307 KSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELE---EHVSHLTEKLLD 363
K RH LQ++I+ +D + D + E +E K LEK + E H + K ++
Sbjct: 453 KCRH-----LQIEIEGLIDQMIDKTKV-EKSEAKAAELEKKLDSELTARHELQVEMKKME 506
Query: 364 LENENMMRVAELEKQLLQREKE-LESIKETYE-NTSHQVHTLRRLIKEKEEAFQRRCHLE 421
+ E ++ + EK L EK+ + + K+ E S + +L KE E+A + L
Sbjct: 507 SDFEQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLS 566
Query: 422 PNVRGLE-SVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPP 480
+ SV S A P P D + P PP PPPP PP PPPPP
Sbjct: 567 AAAITVPPSVPSRAPVPPAPPL------PGDSGTIIPPPPAPGDSTTPPPPPPP-PPPPP 619
Query: 481 PLP-DKCPPAPP-LPG 494
PLP C +PP LPG
Sbjct: 620 PLPGGVCISSPPSLPG 635
>gi|145309324 FH2 domain containing 1 [Homo sapiens]
Length = 1143
Score = 166 bits (419), Expect = 1e-40
Identities = 136/471 (28%), Positives = 219/471 (46%), Gaps = 43/471 (9%)
Query: 457 PAPPPEEVLPLPPPPAPPL------------PPPPPPLPDKCPPAPPLPGAAPSVVLTVG 504
PAPPP P PPPP+PP PPPPPPLP + P PP PG P+ + G
Sbjct: 32 PAPPPP---PPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPPPPGLPPTTHMN-G 87
Query: 505 LSAIRIKKPIKTKFRLPVFNWTALKPNQISG--TVFSELDDEKILEDLDLDKFEELF--- 559
S + KK R+ F W + Q+ G +++ ++ +D EELF
Sbjct: 88 YSHLGKKK------RMRSFFWKTIPEEQVRGKTNIWTLAARQEHHYQIDTKTIEELFGQQ 141
Query: 560 --KTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTF 617
TK+ P + N + ++A ++T+L+A R+ N+ I L++ +S I IH
Sbjct: 142 EDTTKSSLPRRGR--TLNSSFREAREEITILDAKRSMNIGIFLKQFKKSPRSIVEDIHQG 199
Query: 618 DLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMA 677
+ + + ++FLP EVK L+ + + + +L+ D F+ +V + R+
Sbjct: 200 KSEHYGSETLREFLKFLPESEEVKKLKAFSGD---VSKLSLADSFLYGLIQVPNYSLRIE 256
Query: 678 GMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSK-RGAVYG 736
M F + L + + A + S ++L +L ++L GN MN+ G G
Sbjct: 257 AMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIMNAGGYAGNAVG 316
Query: 737 FKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENV--- 793
FKL SL L DTK+ M LLHF+A ++K L NF +LH V+K A +SLEN
Sbjct: 317 FKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLHHVQKTARLSLENTEAE 376
Query: 794 --LLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYF 851
LL V+ E I+R+ + + +FL KL +L+ + ++ ++ +F
Sbjct: 377 LHLLFVRTKSL-KENIQRDGELCQQ--MEDFLQFAIEKLRELECWKQELQDEAYTLIDFF 433
Query: 852 GESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKK 902
E KT F +F F + +A ++N R+ QE ++ QE K+
Sbjct: 434 CEDKKTMKLDECFQIFRDFCTKFNKAVKDNHDREAQELRQLQRLKEQEQKQ 484
>gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2)
interacting protein [Homo sapiens]
Length = 1211
Score = 144 bits (363), Expect = 4e-34
Identities = 129/476 (27%), Positives = 205/476 (43%), Gaps = 80/476 (16%)
Query: 459 PPPEEVLPLPPPPAPPLP----------------------------------PPPPPLPD 484
PPP PL PPP PPLP PPPPPLP
Sbjct: 750 PPP----PLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLPP 805
Query: 485 KCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDE 544
P APP+ L+ GL R + + RL W ++ ++ GT++ +L
Sbjct: 806 PVPCAPPM--------LSRGLGHRRSETSHMSVKRL---RWEQVENSE--GTIWGQLG-- 850
Query: 545 KILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQ--------KAASKVTLLEANRAKNL 596
ED D DK ++ K L+L K A+ + V +L +A N
Sbjct: 851 ---EDSDYDKLSDMVKYLD----LELHFGTQKPAKPVPGPEPFRKKEVVEILSHKKAYNT 903
Query: 597 AITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEEL 656
+I L S E+ + + + + + L + L+ F P E + +Y+ R+ L
Sbjct: 904 SILLAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQ---RYQAFREAPGRL 960
Query: 657 AAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQML 716
+ D+F+L V R+ + F Q+ + + L + AS +K+S+KL ++L
Sbjct: 961 SEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKIL 1020
Query: 717 EIILALGNYMNSS--KRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLAN 774
E +LA+GNY+N K GFK+ L L TK+ D K T LH +A ++ + +P+L
Sbjct: 1021 EFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLG 1080
Query: 775 FWHELHFVEKAAAVSLENVLLDVKELGRGMELIRREC-SIHDNS------VLRNFLSTNE 827
F +L V AA V+ + D+ +L + I+ C SI +S V+ +FL T +
Sbjct: 1081 FAQDLPTVPLAAKVNQRALTSDLADLHGTISEIQDACQSISPSSEDKFAMVMSSFLETAQ 1140
Query: 828 GKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEA 883
L L + A E + +FGE K T FF +F F+ ++ A + +A
Sbjct: 1141 PALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFAEFMSKFERALSDLQA 1196
>gi|157168329 formin 1 [Homo sapiens]
Length = 1196
Score = 138 bits (348), Expect = 2e-32
Identities = 138/562 (24%), Positives = 238/562 (42%), Gaps = 65/562 (11%)
Query: 420 LEPNVRGLESVDSEALARVGPAELSEGMP-PSDLDLLAPAPPPEEVLPLPPPPAPPLPPP 478
L+P + G+ S +AL PA + P PS L L+PAPP V PP P PP PPP
Sbjct: 631 LQP-MEGMASNQQKALPPP-PASIPPPPPLPSGLGSLSPAPPMPPVSAGPPLPPPPPPPP 688
Query: 479 P-----------------------PPLPDKCPPAPPLPGAA----PSVVLTVGLSAIRI- 510
P PP P PPAPP PG A P + +G S+ +
Sbjct: 689 PLPPPSSAGPPPPPPPPPLPNSPAPPNPGGPPPAPPPPGLAPPPPPGLFFGLGSSSSQCP 748
Query: 511 -KKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDL-DLDKFEELFKTKAQGPAL 568
K I+ + WT ++ + S L D D+ D +FE LF
Sbjct: 749 RKPAIEPSCPMKPLYWTRIQISDRSQNATPTLWDSLEEPDIRDPSEFEYLFSKDTTQQKK 808
Query: 569 DLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVE 628
+ + K + LL+ R++ + I + ++I +AI D + ++ +
Sbjct: 809 KPLSETYEKKNKVKKIIKLLDGKRSQTVGILISSLHLEMKDIQQAIFNVDDSVVDLETLA 868
Query: 629 CLMRFLPTEAE-VKLLRQYERER-QPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQ 686
L E E VK+ + YE + + L+ L ++F+ +++ +R + F F
Sbjct: 869 ALYENRAQEDELVKIRKYYETSKEEELKLLDKPEQFLHELAQIPNFAERAQCIIFRSVFS 928
Query: 687 DNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSK--RGAVYGFKLQSLDL 744
+ + L ++ I AS + + +K +L +ILA GNYMN RG G+ L+ L
Sbjct: 929 EGITSLHRKVEIITRASKDLLHVKSVKDILALILAFGNYMNGGNRTRGQADGYSLEILPK 988
Query: 745 LLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEK------AAAVSLENVLLDVK 798
L D KS D + L+ ++ Y A + + + A+ V E+++ D++
Sbjct: 989 LKDVKSRDNGINLVDYVVKYYLRYYDQEAGTEKSVFPLPEPQDFFLASQVKFEDLIKDLR 1048
Query: 799 ELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAK-----------TAEEAYNAV 847
+L R +E ++ + + +L + KL++ + AK A++++
Sbjct: 1049 KLKRQLEASEKQMVVVCKESPKEYLQPFKDKLEEFFQKAKKEHKMEESHLENAQKSFETT 1108
Query: 848 VRYFGESPKT----TPPSVFFPVFVRFIRSYK---EAEQENEARKKQEEVMREKQLAQEA 900
VRYFG PK+ PS F V+ F +K + E +N ++++ +
Sbjct: 1109 VRYFGMKPKSGEKEITPSYVFMVWYEFCSDFKTIWKRESKNISKERLKMAQESVSKLTSE 1168
Query: 901 KKLDAK----TPSQRNKWQQQE 918
KK++ K T S + + +Q+E
Sbjct: 1169 KKVETKKINPTASLKERLRQKE 1190
>gi|58331242 formin homology 2 domain containing 3 [Homo sapiens]
Length = 1439
Score = 116 bits (291), Expect = 9e-26
Identities = 91/350 (26%), Positives = 170/350 (48%), Gaps = 31/350 (8%)
Query: 457 PAPPPEEVLPLPPPPAPPL--PPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPI 514
P PPP L LPPPP PPL PPPP+P PP AP +G S + +P
Sbjct: 847 PPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPVFNAPQ---GLGWSQVPRGQPT 903
Query: 515 KTKFRLPV---------FNWTALKPNQISGTVFSELDDEKILEDLDLDKFEELFKTKAQG 565
TK + + F+W + ++S+L+ K+ D + E LF++K++
Sbjct: 904 FTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLEPIKV----DTSRLEHLFESKSK- 958
Query: 566 PALDLICSKNKTAQKAASKVTLLEANR--AKNLAITLRKAGRSAEEICRAIHTFDLQTLP 623
+L SK A ++ +L++ R A N+ +T+ R+ I AI FD L
Sbjct: 959 ---ELSVSKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPPRT---IKIAILNFDEYALN 1012
Query: 624 VDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLG 683
+ +E ++ +PT+ E + +++ + P L + ++F+L S + L+ R+ AF
Sbjct: 1013 KEGIEKILTMIPTDEEKQKIQEAQL-ANPEIPLGSAEQFLLTLSSISELSARLHLWAFKM 1071
Query: 684 NFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLD 743
+++ + + L + +++++ L +L +LA+GN++N + A F+L L+
Sbjct: 1072 DYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKA---FELSYLE 1128
Query: 744 LLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENV 793
+ + K T K +LLH + V E +PD ++ + E+ + ++A V + +
Sbjct: 1129 KVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQL 1178
Score = 33.1 bits (74), Expect = 1.3
Identities = 29/108 (26%), Positives = 48/108 (44%), Gaps = 3/108 (2%)
Query: 831 DKLQRDAKTAEEAYNAVVRYFGESPKTTPPS-VFFPVFVRFIRSYKEAEQENEARKKQEE 889
D ++ + +Y++ G S TTP S V P R RS + R+ QE
Sbjct: 395 DLREKYSNFGNNSYHSSRPSSGSSVPTTPTSSVSPPQEARLERSSPSGLLTSSFRQHQES 454
Query: 890 VM--REKQLAQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVY 935
+ RE++ + ++L +RNK+ + L +RQA+E R Y
Sbjct: 455 LAAERERRRQEREERLQRIEREERNKFSRDYLDKREEQRQAREERYKY 502
>gi|160707881 formin 2 [Homo sapiens]
Length = 1722
Score = 112 bits (281), Expect = 1e-24
Identities = 121/496 (24%), Positives = 218/496 (43%), Gaps = 60/496 (12%)
Query: 457 PAPPPEEVLPLPPPPAPPLP------PPPPPLPDKCPPAPP---------------LPGA 495
P PPP + +PP PAPPLP PPPP LP PP P LP
Sbjct: 1207 PPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPP 1266
Query: 496 APSVVLTVGLSAIR--IKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILE-DLDL 552
PS + +G++ + K+PI+ + WT ++ + + S L EKI E +D
Sbjct: 1267 LPSGLFGLGMNQDKGSRKQPIEPCRPMKPLYWTRIQLHSKRDSSTS-LIWEKIEEPSIDC 1325
Query: 553 DKFEELF-KTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEIC 611
+FEELF KT + + + +KT KA V LL R++ + I + ++I
Sbjct: 1326 HEFEELFSKTAVKERKKPISDTISKT--KAKQVVKLLSNKRSQAVGILMSSLHLDMKDIQ 1383
Query: 612 RAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYER---ERQPLEELAAEDRFMLLFSK 668
A+ D + ++ ++ L E++ + ++ R +++ + L ++F+ S
Sbjct: 1384 HAVVNLDNSVVDLETLQALYENRAQSDELEKIEKHGRSSKDKENAKSLDKPEQFLYELSL 1443
Query: 669 VERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMN- 727
+ ++R+ + F F +++ + +L + ++K+ + Q+L ++LA GNYMN
Sbjct: 1444 IPNFSERVFCILFQSTFSESICSIRRKLELLQKLCETLKNGPGVMQVLGLVLAFGNYMNG 1503
Query: 728 -SSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWH------ELH 780
+ RG GF L L L D KS+D +LL +I + + A E
Sbjct: 1504 GNKTRGQADGFGLDILPKLKDVKSSDNSRSLLSYIVSYYLRNFDEDAGKEQCLFPLPEPQ 1563
Query: 781 FVEKAAAVSLENVLLDVKELGRGMELIRREC----SIHDNSVLRNFLSTNE-----GKLD 831
+ +A+ + E+ D+++L + ++ E + ++ F E K+D
Sbjct: 1564 DLFQASQMKFEDFQKDLRKLKKDLKACEVEAGKVYQVSSKEHMQPFKENMEQFIIQAKID 1623
Query: 832 KLQRDAKTAE--EAYNAVVRYFGESP----KTTPPSVFFPVFVRFIRSYKEA-EQEN--- 881
+ + E + + YF P K P+ FF ++ F +K+ ++EN
Sbjct: 1624 QEAEENSLTETHKCFLETTAYFFMKPKLGEKEVSPNAFFSIWHEFSSDFKDFWKKENKLL 1683
Query: 882 --EARKKQEEVMREKQ 895
E K+ EEV R+K+
Sbjct: 1684 LQERVKEAEEVCRQKK 1699
Score = 53.5 bits (127), Expect = 9e-07
Identities = 33/79 (41%), Positives = 41/79 (51%), Gaps = 18/79 (22%)
Query: 429 SVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPP-------PAPPLP----P 477
++ S A+ + P + +E +PP P P P +P PPP P PPLP P
Sbjct: 890 TLPSTAIPQPPPLQGTEMLPPP------PPPLPGAGIPPPPPLPGAGILPLPPLPGAGIP 943
Query: 478 PPPPLPDKC-PPAPPLPGA 495
PPPPLP PP PPLPGA
Sbjct: 944 PPPPLPGAAIPPPPPLPGA 962
Score = 52.8 bits (125), Expect = 2e-06
Identities = 31/61 (50%), Positives = 33/61 (54%), Gaps = 13/61 (21%)
Query: 448 PPSDLDLLAPAPP-PEEVLPLPPP-------PAPPLP----PPPPPLPDK-CPPAPPLPG 494
PP + P PP P +PLPPP P PPLP PPPPPLP PP PPLPG
Sbjct: 946 PPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1005
Query: 495 A 495
A
Sbjct: 1006 A 1006
Score = 52.4 bits (124), Expect = 2e-06
Identities = 35/105 (33%), Positives = 43/105 (40%), Gaps = 21/105 (20%)
Query: 413 AFQRRCHLE-----PNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPL 467
AF+ C++ P S+ + P L P+ P PPP + +
Sbjct: 848 AFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEM 907
Query: 468 PPPPAPPLP----PPPPPLPDK------------CPPAPPLPGAA 496
PPP PPLP PPPPPLP PP PPLPGAA
Sbjct: 908 LPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAA 952
Score = 50.4 bits (119), Expect = 8e-06
Identities = 28/55 (50%), Positives = 31/55 (56%), Gaps = 5/55 (9%)
Query: 446 GMPPSDLDLLAPAPPPEEVLPLPPPPAPPLP----PPPPPLPDK-CPPAPPLPGA 495
G+PP A PPP + + PP PPLP PPPPPLP PP PPLPGA
Sbjct: 1084 GIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGA 1138
Score = 50.1 bits (118), Expect = 1e-05
Identities = 30/62 (48%), Positives = 32/62 (51%), Gaps = 19/62 (30%)
Query: 446 GMPPSDLDLLAPAPPPEEVLPLPPP-------PAPPLP----PPPPPLPDK-CPPAPPLP 493
G+PP P P P +P PPP P PPLP PPPPPLP PP PPLP
Sbjct: 974 GIPP-------PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1026
Query: 494 GA 495
GA
Sbjct: 1027 GA 1028
Score = 50.1 bits (118), Expect = 1e-05
Identities = 30/62 (48%), Positives = 32/62 (51%), Gaps = 19/62 (30%)
Query: 446 GMPPSDLDLLAPAPPPEEVLPLPPP-------PAPPLP----PPPPPLPDK-CPPAPPLP 493
G+PP P P P +P PPP P PPLP PPPPPLP PP PPLP
Sbjct: 985 GIPP-------PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1037
Query: 494 GA 495
GA
Sbjct: 1038 GA 1039
Score = 50.1 bits (118), Expect = 1e-05
Identities = 30/62 (48%), Positives = 32/62 (51%), Gaps = 19/62 (30%)
Query: 446 GMPPSDLDLLAPAPPPEEVLPLPPP-------PAPPLP----PPPPPLPDK-CPPAPPLP 493
G+PP P P P +P PPP P PPLP PPPPPLP PP PPLP
Sbjct: 996 GIPP-------PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1048
Query: 494 GA 495
GA
Sbjct: 1049 GA 1050
Score = 50.1 bits (118), Expect = 1e-05
Identities = 30/62 (48%), Positives = 32/62 (51%), Gaps = 19/62 (30%)
Query: 446 GMPPSDLDLLAPAPPPEEVLPLPPP-------PAPPLP----PPPPPLPDK-CPPAPPLP 493
G+PP P P P +P PPP P PPLP PPPPPLP PP PPLP
Sbjct: 1007 GIPP-------PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1059
Query: 494 GA 495
GA
Sbjct: 1060 GA 1061
Score = 50.1 bits (118), Expect = 1e-05
Identities = 30/62 (48%), Positives = 32/62 (51%), Gaps = 19/62 (30%)
Query: 446 GMPPSDLDLLAPAPPPEEVLPLPPP-------PAPPLP----PPPPPLPDK-CPPAPPLP 493
G+PP P P P +P PPP P PPLP PPPPPLP PP PPLP
Sbjct: 1018 GIPP-------PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1070
Query: 494 GA 495
GA
Sbjct: 1071 GA 1072
Score = 50.1 bits (118), Expect = 1e-05
Identities = 30/62 (48%), Positives = 32/62 (51%), Gaps = 19/62 (30%)
Query: 446 GMPPSDLDLLAPAPPPEEVLPLPPP-------PAPPLP----PPPPPLPDK-CPPAPPLP 493
G+PP P P P +P PPP P PPLP PPPPPLP PP PPLP
Sbjct: 1029 GIPP-------PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1081
Query: 494 GA 495
GA
Sbjct: 1082 GA 1083
Score = 50.1 bits (118), Expect = 1e-05
Identities = 30/62 (48%), Positives = 32/62 (51%), Gaps = 19/62 (30%)
Query: 446 GMPPSDLDLLAPAPPPEEVLPLPPP-------PAPPLP----PPPPPLPDK-CPPAPPLP 493
G+PP P P P +P PPP P PPLP PPPPPLP PP PPLP
Sbjct: 1040 GIPP-------PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1092
Query: 494 GA 495
GA
Sbjct: 1093 GA 1094
Score = 50.1 bits (118), Expect = 1e-05
Identities = 30/62 (48%), Positives = 32/62 (51%), Gaps = 19/62 (30%)
Query: 446 GMPPSDLDLLAPAPPPEEVLPLPPP-------PAPPLP----PPPPPLPDK-CPPAPPLP 493
G+PP P P P +P PPP P PPLP PPPPPLP PP PPLP
Sbjct: 1073 GIPP-------PPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLP 1125
Query: 494 GA 495
GA
Sbjct: 1126 GA 1127
Score = 50.1 bits (118), Expect = 1e-05
Identities = 30/62 (48%), Positives = 32/62 (51%), Gaps = 19/62 (30%)
Query: 446 GMPPSDLDLLAPAPPPEEVLPLPPP-------PAPPLP----PPPPPLPDK-CPPAPPLP 493
G+PP P P P +P PPP P PPLP PPPPPLP PP PPLP
Sbjct: 1117 GIPP-------PPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLP 1169
Query: 494 GA 495
GA
Sbjct: 1170 GA 1171
Score = 49.7 bits (117), Expect = 1e-05
Identities = 28/54 (51%), Positives = 30/54 (55%), Gaps = 7/54 (12%)
Query: 447 MPPSDLDLLAPAPPPEEVLPLPPPPAPPLP----PPPPPLPDK-CPPAPPLPGA 495
+PP P PPP +PPPP PLP PPPPPLP PP PPLPGA
Sbjct: 966 LPPPLPGAGIPPPPPLPGAGIPPPP--PLPGAGIPPPPPLPGAGIPPPPPLPGA 1017
Score = 49.7 bits (117), Expect = 1e-05
Identities = 30/62 (48%), Positives = 32/62 (51%), Gaps = 19/62 (30%)
Query: 446 GMPPSDLDLLAPAPPPEEVLPLPPP-------PAPPLP----PPPPPLPDK-CPPAPPLP 493
G+PP P P P +P PPP P PPLP PPPPPLP PP PPLP
Sbjct: 1062 GIPP-------PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLP 1114
Query: 494 GA 495
GA
Sbjct: 1115 GA 1116
Score = 49.7 bits (117), Expect = 1e-05
Identities = 30/62 (48%), Positives = 32/62 (51%), Gaps = 19/62 (30%)
Query: 446 GMPPSDLDLLAPAPPPEEVLPLPPP-------PAPPLP----PPPPPLPDK-CPPAPPLP 493
G+PP P P P +P PPP P PPLP PPPPPLP PP PPLP
Sbjct: 1150 GIPP-------PPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLP 1202
Query: 494 GA 495
GA
Sbjct: 1203 GA 1204
Score = 49.3 bits (116), Expect = 2e-05
Identities = 30/62 (48%), Positives = 32/62 (51%), Gaps = 19/62 (30%)
Query: 446 GMPPSDLDLLAPAPPPEEVLPLPPP-------PAPPLP----PPPPPLPDK-CPPAPPLP 493
G+PP P P P +P PPP P PPLP PPPPPLP PP PPLP
Sbjct: 1106 GIPP-------PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLP 1158
Query: 494 GA 495
GA
Sbjct: 1159 GA 1160
Score = 48.9 bits (115), Expect = 2e-05
Identities = 27/54 (50%), Positives = 30/54 (55%), Gaps = 5/54 (9%)
Query: 446 GMPPSDLDLLAPAPPPEEVLPLPPPPAPPLP----PPPPPLPDK-CPPAPPLPG 494
G+PP A PPP + + PP PPLP PPPPPLP PP PPLPG
Sbjct: 1128 GIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1181
Score = 47.4 bits (111), Expect = 7e-05
Identities = 30/63 (47%), Positives = 32/63 (50%), Gaps = 21/63 (33%)
Query: 446 GMPPSDLDLLAPAPPPEEVLPLPPPPAP----PLP--------PPPPPLPDK-CPPAPPL 492
G+PP P P P +P PPPP P PLP PPPPPLP PP PPL
Sbjct: 941 GIPP-------PPPLPGAAIP-PPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPL 992
Query: 493 PGA 495
PGA
Sbjct: 993 PGA 995
Score = 45.1 bits (105), Expect = 3e-04
Identities = 25/52 (48%), Positives = 27/52 (51%), Gaps = 14/52 (26%)
Query: 457 PAPPPEEVLPLPPPP------APPLP-------PPPPPLPD-KCPPAPPLPG 494
P PPP + +PPPP PP P PPPPPLP PP PPLPG
Sbjct: 1141 PPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPG 1192
Score = 44.7 bits (104), Expect = 4e-04
Identities = 25/52 (48%), Positives = 26/52 (50%), Gaps = 14/52 (26%)
Query: 457 PAPPPEEVLPLPPPP------APPLP-------PPPPPLPDK-CPPAPPLPG 494
P PPP +PPPP PP P PPPPPLP PP PPLPG
Sbjct: 1053 PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1104
Score = 43.1 bits (100), Expect = 0.001
Identities = 24/51 (47%), Positives = 26/51 (50%), Gaps = 14/51 (27%)
Query: 457 PAPPPEEVLPLPPPP------APPLP-------PPPPPLPDK-CPPAPPLP 493
P PPP + +PPPP PP P PPPPPLP PP PPLP
Sbjct: 1097 PPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1147
Score = 42.0 bits (97), Expect = 0.003
Identities = 29/60 (48%), Positives = 30/60 (50%), Gaps = 14/60 (23%)
Query: 448 PPSDLDLLAPAPPPEEVLPLPP---PPAPPLP----PPPPPLPDK-CPPAPPL--PGAAP 497
PP L + PPP PLP PP PPLP PPPPPLP PP PPL G P
Sbjct: 1098 PPPPLPGVGIPPPP----PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPP 1153
>gi|118572599 formin homology 2 domain containing 1 [Homo sapiens]
Length = 1164
Score = 107 bits (267), Expect = 5e-23
Identities = 108/457 (23%), Positives = 207/457 (45%), Gaps = 32/457 (7%)
Query: 453 DLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIK- 511
D+ AP+PP + +PPPP PL PPPPP+ PP PPLP AAP SA+ K
Sbjct: 568 DIPAPSPPLPLLSGVPPPP--PL-PPPPPIKGPFPPPPPLPLAAPLPHSVPDSSALPTKR 624
Query: 512 KPIKTKFR-LPVFNWTALKPNQIS--GTVFSELDDEKILEDLDLDKFEELFKTKAQGPAL 568
K +K +R L + + ++ T+++ LD + D + E LF+++A+
Sbjct: 625 KTVKLFWRELKLAGGHGVSASRFGPCATLWASLDPVSV----DTARLEHLFESRAK---- 676
Query: 569 DLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVE 628
+++ SK K + + T+L+ R+ + I L I A+ FD + D +E
Sbjct: 677 EVLPSK-KAGEGRRTMTTVLDPKRSNAINIGLTTL-PPVHVIKAALLNFDEFAVSKDGIE 734
Query: 629 CLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDN 688
L+ +PTE E + + + + P L + F++ + + L R+ AF ++
Sbjct: 735 KLLTMMPTEEERQKIEEAQL-ANPDIPLGPAENFLMTLASIGGLAARLQLWAFKLDYDSM 793
Query: 689 LQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDT 748
+ + L + + + + +L +LA+GN++N S+ GF+L L+ + +
Sbjct: 794 EREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNGSQSS---GFELSYLEKVSEV 850
Query: 749 KSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKEL---GRGME 805
K T R+ +LLH + V + P+ ++ + E+ + + A V E + ++ +L R E
Sbjct: 851 KDTVRRQSLLHHLCSLVLQTRPESSDLYSEIPALTRCAKVDFEQLTENLGQLERRSRAAE 910
Query: 806 LIRRECSIHD-----NSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPP 860
R + H+ + L +FL ++ L+ + ++A + Y G +P+
Sbjct: 911 ESLRSLAKHELAPALRARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYLGYTPQAARE 970
Query: 861 ---SVFFPVFVRFIRSYKEAEQENEARKKQEEVMREK 894
F F Y+ + +++++ RE+
Sbjct: 971 VRIMQFCHTLREFALEYRTCRERVLQQQQKQATYRER 1007
>gi|14249316 hypothetical protein LOC84800 [Homo sapiens]
Length = 234
Score = 94.0 bits (232), Expect = 6e-19
Identities = 61/188 (32%), Positives = 98/188 (52%), Gaps = 17/188 (9%)
Query: 123 GWVREFLNDENKGLDVLVDYLSFAQCSVMYSTLPGRRALKNSRLVSQKDDVHVCILCLRA 182
GW+ +FL E GLD+L++ L+ L GR + S + Q C+ C+RA
Sbjct: 63 GWMVQFL--EQSGLDLLLEALA---------RLSGRGVARISDALLQL----TCVSCVRA 107
Query: 183 IMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVR-GGHEIILAAFDN 241
+MN + G ++S+ V +++ +L+ N K V ELLAA+C+ GH + L A D+
Sbjct: 108 VMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDH 167
Query: 242 FKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGL 301
+K VC + +RF +M D N+ ++V + IN V+ ED+ R L+ EF L L
Sbjct: 168 YKTVCSQQYRFSIVMNELSGSD-NVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQL 226
Query: 302 EEFLQKSR 309
+ L + R
Sbjct: 227 LDVLARLR 234
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 61.6 bits (148), Expect = 3e-09
Identities = 61/202 (30%), Positives = 87/202 (43%), Gaps = 41/202 (20%)
Query: 335 EDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAELEKQ-LLQREKELESIK--E 391
E E + + E++E L ++ L+ E + R LE+Q L+R++ LE + +
Sbjct: 164 ERMERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLD 223
Query: 392 TYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLE------------SVDSEALARVG 439
+ L RL +E++E +R+ LE E SV++ + +G
Sbjct: 224 RERQERQERERLERLERERQER-ERQEQLEREQLEWERERRISSAAAPASVETPLNSVLG 282
Query: 440 PAELSE---------GMPPSD----LDLLAPAPPPEEVLPLPPPPA--------PPLPPP 478
+ SE PS L LAP PPP PLPP PA PP PPP
Sbjct: 283 DSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPP----PLPPGPAQASVALPPPPGPPP 338
Query: 479 PPPLPDKCPPAPPLPGAAPSVV 500
PPPLP PP PP P P+ V
Sbjct: 339 PPPLPSTGPPPPPPPPPLPNQV 360
Score = 30.4 bits (67), Expect = 8.4
Identities = 15/59 (25%), Positives = 34/59 (57%), Gaps = 1/59 (1%)
Query: 875 KEAEQENEARKKQEEVMREKQL-AQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHR 932
++ E+E + R++QE + R+++L QE + + +R + Q++E + L R + + R
Sbjct: 189 EQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERER 247
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 61.6 bits (148), Expect = 3e-09
Identities = 61/202 (30%), Positives = 87/202 (43%), Gaps = 41/202 (20%)
Query: 335 EDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAELEKQ-LLQREKELESIK--E 391
E E + + E++E L ++ L+ E + R LE+Q L+R++ LE + +
Sbjct: 164 ERMERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLD 223
Query: 392 TYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLE------------SVDSEALARVG 439
+ L RL +E++E +R+ LE E SV++ + +G
Sbjct: 224 RERQERQERERLERLERERQER-ERQEQLEREQLEWERERRISSAAAPASVETPLNSVLG 282
Query: 440 PAELSE---------GMPPSD----LDLLAPAPPPEEVLPLPPPPA--------PPLPPP 478
+ SE PS L LAP PPP PLPP PA PP PPP
Sbjct: 283 DSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPP----PLPPGPAQASVALPPPPGPPP 338
Query: 479 PPPLPDKCPPAPPLPGAAPSVV 500
PPPLP PP PP P P+ V
Sbjct: 339 PPPLPSTGPPPPPPPPPLPNQV 360
Score = 30.4 bits (67), Expect = 8.4
Identities = 15/59 (25%), Positives = 34/59 (57%), Gaps = 1/59 (1%)
Query: 875 KEAEQENEARKKQEEVMREKQL-AQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHR 932
++ E+E + R++QE + R+++L QE + + +R + Q++E + L R + + R
Sbjct: 189 EQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERER 247
>gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Homo
sapiens]
Length = 1188
Score = 59.3 bits (142), Expect = 2e-08
Identities = 70/244 (28%), Positives = 98/244 (40%), Gaps = 36/244 (14%)
Query: 436 ARVGPAELSEGMPPSDLDLLAPAPP-------PEEVLPLPPPPAPPLPPPPPPLPDKCPP 488
++V P E P +L APA P + PPPAPPLPPP PPLP PP
Sbjct: 350 SQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLP---PP 406
Query: 489 APPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKP--------NQISGTVFSE 540
APPLP AAP + A + P + P + ALKP N S
Sbjct: 407 APPLPPAAPPLP-----CAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDW 461
Query: 541 LDD---EKILEDLDL----DKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRA 593
D EK+ +L + E+ F + GP + + K + K TLL A
Sbjct: 462 RDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSL-PA 520
Query: 594 KNL--AITLRKAGRSAEEICRAIHTFDLQT---LPVDFVECLMRFLPTEAEVKLLRQYER 648
K+ + + G S+ A + L + +P D +R + E E +L E+
Sbjct: 521 KDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEK 580
Query: 649 ERQP 652
E +P
Sbjct: 581 EAKP 584
Score = 49.3 bits (116), Expect = 2e-05
Identities = 32/78 (41%), Positives = 36/78 (46%), Gaps = 22/78 (28%)
Query: 440 PAELSEGMPPSDLDLLAP---APPPEEVLPLPPPPAPPLPPPPPPL-------------- 482
P ++SE PP L +P APPP +L PPPP PPPPP L
Sbjct: 151 PQDISE--PPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSI 208
Query: 483 ---PDKCPPAPPLPGAAP 497
PD PPAPPL AP
Sbjct: 209 PTPPDFIPPAPPLAFLAP 226
Score = 47.8 bits (112), Expect = 5e-05
Identities = 31/80 (38%), Positives = 33/80 (41%), Gaps = 27/80 (33%)
Query: 440 PAELSEGMPPSDLDLLAPAPPPEEVLPLPP-----------------------PPAPPL- 475
P+ S PP L LL P PPP P PP PPAPPL
Sbjct: 164 PSPPSTAPPPPPL-LLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLA 222
Query: 476 --PPPPPPLPDKCPPAPPLP 493
PPPPP+P PPAP P
Sbjct: 223 FLAPPPPPVPAPAPPAPASP 242
Score = 43.5 bits (101), Expect = 0.001
Identities = 22/48 (45%), Positives = 24/48 (50%), Gaps = 7/48 (14%)
Query: 448 PPSDLDLLAPAPPPEEVLPLPPPPAPPLPP---PPPPLPDKCPPAPPL 492
PP D+ PP LP PP APP PP PPP P PP PP+
Sbjct: 150 PPQDIS----EPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPV 193
Score = 38.9 bits (89), Expect = 0.024
Identities = 24/59 (40%), Positives = 27/59 (45%), Gaps = 11/59 (18%)
Query: 453 DLLAPAPPPEEVLPLP-----PPPAPPLP------PPPPPLPDKCPPAPPLPGAAPSVV 500
DLL P PPP P PP PLP PPPPPL + PP P + P V+
Sbjct: 136 DLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVL 194
>gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Homo
sapiens]
Length = 1188
Score = 59.3 bits (142), Expect = 2e-08
Identities = 70/244 (28%), Positives = 98/244 (40%), Gaps = 36/244 (14%)
Query: 436 ARVGPAELSEGMPPSDLDLLAPAPP-------PEEVLPLPPPPAPPLPPPPPPLPDKCPP 488
++V P E P +L APA P + PPPAPPLPPP PPLP PP
Sbjct: 350 SQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLP---PP 406
Query: 489 APPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKP--------NQISGTVFSE 540
APPLP AAP + A + P + P + ALKP N S
Sbjct: 407 APPLPPAAPPLP-----CAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDW 461
Query: 541 LDD---EKILEDLDL----DKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRA 593
D EK+ +L + E+ F + GP + + K + K TLL A
Sbjct: 462 RDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSL-PA 520
Query: 594 KNL--AITLRKAGRSAEEICRAIHTFDLQT---LPVDFVECLMRFLPTEAEVKLLRQYER 648
K+ + + G S+ A + L + +P D +R + E E +L E+
Sbjct: 521 KDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEK 580
Query: 649 ERQP 652
E +P
Sbjct: 581 EAKP 584
Score = 49.3 bits (116), Expect = 2e-05
Identities = 32/78 (41%), Positives = 36/78 (46%), Gaps = 22/78 (28%)
Query: 440 PAELSEGMPPSDLDLLAP---APPPEEVLPLPPPPAPPLPPPPPPL-------------- 482
P ++SE PP L +P APPP +L PPPP PPPPP L
Sbjct: 151 PQDISE--PPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSI 208
Query: 483 ---PDKCPPAPPLPGAAP 497
PD PPAPPL AP
Sbjct: 209 PTPPDFIPPAPPLAFLAP 226
Score = 47.8 bits (112), Expect = 5e-05
Identities = 31/80 (38%), Positives = 33/80 (41%), Gaps = 27/80 (33%)
Query: 440 PAELSEGMPPSDLDLLAPAPPPEEVLPLPP-----------------------PPAPPL- 475
P+ S PP L LL P PPP P PP PPAPPL
Sbjct: 164 PSPPSTAPPPPPL-LLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLA 222
Query: 476 --PPPPPPLPDKCPPAPPLP 493
PPPPP+P PPAP P
Sbjct: 223 FLAPPPPPVPAPAPPAPASP 242
Score = 43.5 bits (101), Expect = 0.001
Identities = 22/48 (45%), Positives = 24/48 (50%), Gaps = 7/48 (14%)
Query: 448 PPSDLDLLAPAPPPEEVLPLPPPPAPPLPP---PPPPLPDKCPPAPPL 492
PP D+ PP LP PP APP PP PPP P PP PP+
Sbjct: 150 PPQDIS----EPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPV 193
Score = 38.9 bits (89), Expect = 0.024
Identities = 24/59 (40%), Positives = 27/59 (45%), Gaps = 11/59 (18%)
Query: 453 DLLAPAPPPEEVLPLP-----PPPAPPLP------PPPPPLPDKCPPAPPLPGAAPSVV 500
DLL P PPP P PP PLP PPPPPL + PP P + P V+
Sbjct: 136 DLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVL 194
>gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo
sapiens]
Length = 1188
Score = 59.3 bits (142), Expect = 2e-08
Identities = 70/244 (28%), Positives = 98/244 (40%), Gaps = 36/244 (14%)
Query: 436 ARVGPAELSEGMPPSDLDLLAPAPP-------PEEVLPLPPPPAPPLPPPPPPLPDKCPP 488
++V P E P +L APA P + PPPAPPLPPP PPLP PP
Sbjct: 350 SQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLP---PP 406
Query: 489 APPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKP--------NQISGTVFSE 540
APPLP AAP + A + P + P + ALKP N S
Sbjct: 407 APPLPPAAPPLP-----CAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDW 461
Query: 541 LDD---EKILEDLDL----DKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRA 593
D EK+ +L + E+ F + GP + + K + K TLL A
Sbjct: 462 RDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSL-PA 520
Query: 594 KNL--AITLRKAGRSAEEICRAIHTFDLQT---LPVDFVECLMRFLPTEAEVKLLRQYER 648
K+ + + G S+ A + L + +P D +R + E E +L E+
Sbjct: 521 KDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEK 580
Query: 649 ERQP 652
E +P
Sbjct: 581 EAKP 584
Score = 49.3 bits (116), Expect = 2e-05
Identities = 32/78 (41%), Positives = 36/78 (46%), Gaps = 22/78 (28%)
Query: 440 PAELSEGMPPSDLDLLAP---APPPEEVLPLPPPPAPPLPPPPPPL-------------- 482
P ++SE PP L +P APPP +L PPPP PPPPP L
Sbjct: 151 PQDISE--PPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSI 208
Query: 483 ---PDKCPPAPPLPGAAP 497
PD PPAPPL AP
Sbjct: 209 PTPPDFIPPAPPLAFLAP 226
Score = 47.8 bits (112), Expect = 5e-05
Identities = 31/80 (38%), Positives = 33/80 (41%), Gaps = 27/80 (33%)
Query: 440 PAELSEGMPPSDLDLLAPAPPPEEVLPLPP-----------------------PPAPPL- 475
P+ S PP L LL P PPP P PP PPAPPL
Sbjct: 164 PSPPSTAPPPPPL-LLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLA 222
Query: 476 --PPPPPPLPDKCPPAPPLP 493
PPPPP+P PPAP P
Sbjct: 223 FLAPPPPPVPAPAPPAPASP 242
Score = 43.5 bits (101), Expect = 0.001
Identities = 22/48 (45%), Positives = 24/48 (50%), Gaps = 7/48 (14%)
Query: 448 PPSDLDLLAPAPPPEEVLPLPPPPAPPLPP---PPPPLPDKCPPAPPL 492
PP D+ PP LP PP APP PP PPP P PP PP+
Sbjct: 150 PPQDIS----EPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPV 193
Score = 38.9 bits (89), Expect = 0.024
Identities = 24/59 (40%), Positives = 27/59 (45%), Gaps = 11/59 (18%)
Query: 453 DLLAPAPPPEEVLPLP-----PPPAPPLP------PPPPPLPDKCPPAPPLPGAAPSVV 500
DLL P PPP P PP PLP PPPPPL + PP P + P V+
Sbjct: 136 DLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVL 194
>gi|153792074 proline rich 12 [Homo sapiens]
Length = 2036
Score = 57.8 bits (138), Expect = 5e-08
Identities = 32/68 (47%), Positives = 35/68 (51%), Gaps = 18/68 (26%)
Query: 440 PAELSEGMPPSDLDLLAPAPPPEEVLPLPP---------PPAPPLPPPPPP-LPDKCPPA 489
PA + PP P PPP+ LP PP PP PPLPPPPPP +P PP
Sbjct: 1463 PAPTPQPQPPP------PPPPPQPALPSPPPLVAPTPSSPPPPPLPPPPPPAMPS--PPP 1514
Query: 490 PPLPGAAP 497
PP P AAP
Sbjct: 1515 PPPPAAAP 1522
Score = 53.9 bits (128), Expect = 7e-07
Identities = 29/52 (55%), Positives = 30/52 (57%), Gaps = 2/52 (3%)
Query: 449 PSDLDLLAPAP--PPEEVLPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPS 498
PS L+AP P PP LP PPPPA P PPPPPP APP AAPS
Sbjct: 1483 PSPPPLVAPTPSSPPPPPLPPPPPPAMPSPPPPPPPAAAPLAAPPEEPAAPS 1534
Score = 46.6 bits (109), Expect = 1e-04
Identities = 37/132 (28%), Positives = 50/132 (37%), Gaps = 22/132 (16%)
Query: 390 KETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRG-LESVDSEALARVGPAELSEGMP 448
K E + TL ++E++ + L+ ++ + ++D LA +G P
Sbjct: 1364 KRLDEELKRNLETLPSFSSDEEDSVAKNRDLQESISSAISALDDPPLAGPKDTSTPDG-P 1422
Query: 449 PSDLDLLAPAPPP------------------EEVLPLPPPPAPPLPPPPPPLPDKCPPAP 490
P P PPP EE P PPPAP P PPP P PP P
Sbjct: 1423 PLAPAAAVPGPPPLPGLPSANSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPPP--PPQP 1480
Query: 491 PLPGAAPSVVLT 502
LP P V T
Sbjct: 1481 ALPSPPPLVAPT 1492
Score = 45.8 bits (107), Expect = 2e-04
Identities = 28/68 (41%), Positives = 30/68 (44%), Gaps = 11/68 (16%)
Query: 440 PAELSEGMP-PSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPD---------KCPPA 489
P+ S G P P L+ P PP P P PP PP PPP P LP PP
Sbjct: 1440 PSANSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPP-PPPQPALPSPPPLVAPTPSSPPP 1498
Query: 490 PPLPGAAP 497
PPLP P
Sbjct: 1499 PPLPPPPP 1506
Score = 36.2 bits (82), Expect = 0.15
Identities = 25/63 (39%), Positives = 25/63 (39%), Gaps = 9/63 (14%)
Query: 438 VGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAP---PLPPPPPPLPDKCPPAPPLPG 494
V P S PP L P PPP P PPPP P PL PP P P LP
Sbjct: 1489 VAPTPSSPPPPP-----LPPPPPPAMPSP-PPPPPPAAAPLAAPPEEPAAPSPEDPELPD 1542
Query: 495 AAP 497
P
Sbjct: 1543 TRP 1545
Score = 35.0 bits (79), Expect = 0.34
Identities = 30/103 (29%), Positives = 37/103 (35%), Gaps = 28/103 (27%)
Query: 422 PNVRGLESVDSEALARVGPAELSEGMPPSDLDLL------APAPPPE------------- 462
P + + L G +L +PP LL AP+P P
Sbjct: 769 PTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVGVHLLEPAT 828
Query: 463 -EVLPLPPPPAPPLPPPPPPLPDKC-------PPAPPLPGAAP 497
+ P PPPP PP PPPP PL + PA P P P
Sbjct: 829 RDGAPQPPPP-PPPPPPPMPLQLEAHLRSHGLEPAAPSPRLRP 870
Score = 35.0 bits (79), Expect = 0.34
Identities = 25/79 (31%), Positives = 34/79 (43%), Gaps = 6/79 (7%)
Query: 439 GPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPS 498
GP G+ P+ L E + + P PPPPPP PP PP P + P
Sbjct: 1002 GPETPGLGLDPNKPPELPSTVNAEPLGLIQSGPHQAAPPPPPP-----PPPPPAPASEPK 1056
Query: 499 VVLTVGL-SAIRIKKPIKT 516
LT + + + KK +KT
Sbjct: 1057 GGLTSPIFCSTKPKKLLKT 1075
Score = 33.9 bits (76), Expect = 0.76
Identities = 26/86 (30%), Positives = 31/86 (36%), Gaps = 37/86 (43%)
Query: 440 PAELSEGMPPSDLDLLAPAPPPEEVLPLPPPP----------AP---------------- 473
P ++ P+ LL A P+ L LPPPP AP
Sbjct: 767 PPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVGVHLLEP 826
Query: 474 ------PLPPPPPPLPDKCPPAPPLP 493
P PPPPPP PP PP+P
Sbjct: 827 ATRDGAPQPPPPPP-----PPPPPMP 847
Score = 31.2 bits (69), Expect = 5.0
Identities = 15/39 (38%), Positives = 17/39 (43%), Gaps = 3/39 (7%)
Query: 458 APPPEEVLPLPPPPAP---PLPPPPPPLPDKCPPAPPLP 493
APPP+ P P P P PP P+ P PP P
Sbjct: 1691 APPPKAPAPPPKPETPEKTTSEKPPEQTPETAMPEPPAP 1729
Score = 30.8 bits (68), Expect = 6.5
Identities = 15/36 (41%), Positives = 17/36 (47%), Gaps = 6/36 (16%)
Query: 456 APAPPPEEVLP------LPPPPAPPLPPPPPPLPDK 485
APAPPP+ P PP P P PP P+K
Sbjct: 1696 APAPPPKPETPEKTTSEKPPEQTPETAMPEPPAPEK 1731
Score = 30.4 bits (67), Expect = 8.4
Identities = 13/33 (39%), Positives = 15/33 (45%), Gaps = 1/33 (3%)
Query: 469 PPPAPPLPPPPPPLPDKCPPAPPLPGAAPSVVL 501
PPP P PPP P P+K P P P +
Sbjct: 1692 PPPKAPAPPPKPETPEKTTSEKP-PEQTPETAM 1723
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 57.0 bits (136), Expect = 8e-08
Identities = 30/64 (46%), Positives = 32/64 (50%), Gaps = 5/64 (7%)
Query: 440 PAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPSV 499
PA+ S LD+ A PPP PPPP PP PPPPPP P PP P P P
Sbjct: 2387 PAKPRPFFRSSSLDISAQPPPPP-----PPPPPPPPPPPPPPPPPLPPPTSPKPTILPKK 2441
Query: 500 VLTV 503
LTV
Sbjct: 2442 KLTV 2445
Score = 45.1 bits (105), Expect = 3e-04
Identities = 19/47 (40%), Positives = 23/47 (48%)
Query: 470 PPAPPLPPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKT 516
PP PP PPPPPP P PP PPLP + + + P+ T
Sbjct: 2405 PPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTT 2451
Score = 38.9 bits (89), Expect = 0.024
Identities = 24/65 (36%), Positives = 25/65 (38%)
Query: 433 EALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPAPPL 492
E + PA PS L A P L PP PPPPPP P PP PP
Sbjct: 2365 ETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPP 2424
Query: 493 PGAAP 497
P P
Sbjct: 2425 PPLPP 2429
Score = 37.0 bits (84), Expect = 0.090
Identities = 24/60 (40%), Positives = 28/60 (46%), Gaps = 14/60 (23%)
Query: 448 PPSDLDLLAPA-PPPEEVLPLPPPPAPP---LPP--------PPPPLPDKCPPAPPLPGA 495
PPS L PA PPP++ P PPP P PP PPP P P+P PG+
Sbjct: 469 PPSQLP--GPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGS 526
Score = 33.1 bits (74), Expect = 1.3
Identities = 31/101 (30%), Positives = 43/101 (42%), Gaps = 8/101 (7%)
Query: 426 GLESVDSEALARVGPAELSE--GMPPSDLDLLAPAPPPEEVLPLPPPPA--PPLPPPPP- 480
G E SE + GP L++ G+ + PA PP + + P P A P L P
Sbjct: 377 GSEKPSSE---QPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKA 433
Query: 481 PLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLP 521
P P K P P PG P+ G ++ + P K +LP
Sbjct: 434 PGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLP 474
Score = 31.2 bits (69), Expect = 5.0
Identities = 16/42 (38%), Positives = 18/42 (42%), Gaps = 6/42 (14%)
Query: 457 PAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPS 498
P PP ++ P P PPP P P K PP P PS
Sbjct: 466 PTKPPSQL------PGPAKPPPQQPGPAKPPPQQPGSAKPPS 501
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 57.0 bits (136), Expect = 8e-08
Identities = 30/64 (46%), Positives = 32/64 (50%), Gaps = 5/64 (7%)
Query: 440 PAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPSV 499
PA+ S LD+ A PPP PPPP PP PPPPPP P PP P P P
Sbjct: 2387 PAKPRPFFRSSSLDISAQPPPPP-----PPPPPPPPPPPPPPPPPLPPPTSPKPTILPKK 2441
Query: 500 VLTV 503
LTV
Sbjct: 2442 KLTV 2445
Score = 45.1 bits (105), Expect = 3e-04
Identities = 19/47 (40%), Positives = 23/47 (48%)
Query: 470 PPAPPLPPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKT 516
PP PP PPPPPP P PP PPLP + + + P+ T
Sbjct: 2405 PPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTT 2451
Score = 38.9 bits (89), Expect = 0.024
Identities = 24/65 (36%), Positives = 25/65 (38%)
Query: 433 EALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPAPPL 492
E + PA PS L A P L PP PPPPPP P PP PP
Sbjct: 2365 ETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPP 2424
Query: 493 PGAAP 497
P P
Sbjct: 2425 PPLPP 2429
Score = 37.0 bits (84), Expect = 0.090
Identities = 24/60 (40%), Positives = 28/60 (46%), Gaps = 14/60 (23%)
Query: 448 PPSDLDLLAPA-PPPEEVLPLPPPPAPP---LPP--------PPPPLPDKCPPAPPLPGA 495
PPS L PA PPP++ P PPP P PP PPP P P+P PG+
Sbjct: 469 PPSQLP--GPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGS 526
Score = 33.1 bits (74), Expect = 1.3
Identities = 31/101 (30%), Positives = 43/101 (42%), Gaps = 8/101 (7%)
Query: 426 GLESVDSEALARVGPAELSE--GMPPSDLDLLAPAPPPEEVLPLPPPPA--PPLPPPPP- 480
G E SE + GP L++ G+ + PA PP + + P P A P L P
Sbjct: 377 GSEKPSSE---QPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKA 433
Query: 481 PLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLP 521
P P K P P PG P+ G ++ + P K +LP
Sbjct: 434 PGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLP 474
Score = 31.2 bits (69), Expect = 5.0
Identities = 16/42 (38%), Positives = 18/42 (42%), Gaps = 6/42 (14%)
Query: 457 PAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPS 498
P PP ++ P P PPP P P K PP P PS
Sbjct: 466 PTKPPSQL------PGPAKPPPQQPGPAKPPPQQPGSAKPPS 501
>gi|187761324 shootin1 isoform a [Homo sapiens]
Length = 631
Score = 57.0 bits (136), Expect = 8e-08
Identities = 46/175 (26%), Positives = 81/175 (46%), Gaps = 26/175 (14%)
Query: 312 ESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMR 371
E E++QV ++ D ++ + L++ L S ++LL +EN
Sbjct: 213 EYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKL 272
Query: 372 VAELEKQLLQREKELESIKETYEN-TSH-QVHTLRR----LIKEKEEAFQRRCHLEPNVR 425
+LE++ +Q +++++ ++E EN T H ++H L++ L ++K+E + + E R
Sbjct: 273 TQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKAR 332
Query: 426 GLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPP 480
L+ E RV +E S +P PPPP PPLPPPPP
Sbjct: 333 NLKHSVDELQKRVNQSENS--------------------VPPPPPPPPPLPPPPP 367
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,464,784
Number of Sequences: 37866
Number of extensions: 2251449
Number of successful extensions: 61134
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 848
Number of HSP's successfully gapped in prelim test: 1024
Number of HSP's that attempted gapping in prelim test: 24219
Number of HSP's gapped (non-prelim): 19306
length of query: 976
length of database: 18,247,518
effective HSP length: 112
effective length of query: 864
effective length of database: 14,006,526
effective search space: 12101638464
effective search space used: 12101638464
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.