BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|239750456 PREDICTED: similar to KIAA0655 protein [Homo sapiens] (1048 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|239750456 PREDICTED: similar to KIAA0655 protein [Homo sapiens] 2030 0.0 gi|48762942 huntingtin interacting protein-1-related [Homo sapiens] 1822 0.0 gi|38045919 huntingtin interacting protein 1 [Homo sapiens] 842 0.0 gi|223029410 talin 1 [Homo sapiens] 109 2e-23 gi|156938343 talin 2 [Homo sapiens] 108 3e-23 gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 92 3e-18 gi|21735548 centrosomal protein 2 [Homo sapiens] 91 6e-18 gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 84 7e-16 gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 81 5e-15 gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 80 8e-15 gi|148746195 trichohyalin [Homo sapiens] 80 8e-15 gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 80 8e-15 gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 80 1e-14 gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 80 1e-14 gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 79 2e-14 gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 79 2e-14 gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 79 2e-14 gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 79 2e-14 gi|41322923 plectin 1 isoform 11 [Homo sapiens] 79 2e-14 gi|41322914 plectin 1 isoform 10 [Homo sapiens] 79 2e-14 gi|41322919 plectin 1 isoform 8 [Homo sapiens] 79 2e-14 gi|41322910 plectin 1 isoform 7 [Homo sapiens] 79 2e-14 gi|41322916 plectin 1 isoform 6 [Homo sapiens] 79 2e-14 gi|41322908 plectin 1 isoform 3 [Homo sapiens] 79 2e-14 gi|41322912 plectin 1 isoform 2 [Homo sapiens] 79 2e-14 gi|47607492 plectin 1 isoform 1 [Homo sapiens] 79 2e-14 gi|21450705 leucine rich repeat containing 45 [Homo sapiens] 79 2e-14 gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 79 3e-14 gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 79 3e-14 gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 79 3e-14 >gi|239750456 PREDICTED: similar to KIAA0655 protein [Homo sapiens] Length = 1048 Score = 2030 bits (5260), Expect = 0.0 Identities = 1048/1048 (100%), Positives = 1048/1048 (100%) Query: 1 MWQDHSPGTSVVREPVAGRRFLGSPRPAAEESGLEVCILSTHTVRPESPGGPAIWMHCKT 60 MWQDHSPGTSVVREPVAGRRFLGSPRPAAEESGLEVCILSTHTVRPESPGGPAIWMHCKT Sbjct: 1 MWQDHSPGTSVVREPVAGRRFLGSPRPAAEESGLEVCILSTHTVRPESPGGPAIWMHCKT 60 Query: 61 SGVRDVPGGQRALAWFSLEHCGVLVCLGRDIGAGQALDRGHLHDRYGQLVNVYTKLLLTK 120 SGVRDVPGGQRALAWFSLEHCGVLVCLGRDIGAGQALDRGHLHDRYGQLVNVYTKLLLTK Sbjct: 61 SGVRDVPGGQRALAWFSLEHCGVLVCLGRDIGAGQALDRGHLHDRYGQLVNVYTKLLLTK 120 Query: 121 ISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLNTA 180 ISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLNTA Sbjct: 121 ISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLNTA 180 Query: 181 IAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHSCLPADTLQGHRDRFHEQFHSL 240 IAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHSCLPADTLQGHRDRFHEQFHSL Sbjct: 181 IAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHSCLPADTLQGHRDRFHEQFHSL 240 Query: 241 RNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIKPVVVIPEEAPEDEEPENLIE 300 RNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIKPVVVIPEEAPEDEEPENLIE Sbjct: 241 RNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIKPVVVIPEEAPEDEEPENLIE 300 Query: 301 ISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRY 360 ISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRY Sbjct: 301 ISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRY 360 Query: 361 IAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKA 420 IAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKA Sbjct: 361 IAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKA 420 Query: 421 SATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVK 480 SATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVK Sbjct: 421 SATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVK 480 Query: 481 RESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALS 540 RESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALS Sbjct: 481 RESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALS 540 Query: 541 GAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQ 600 GAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQ Sbjct: 541 GAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQ 600 Query: 601 FAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLT 660 FAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLT Sbjct: 601 FAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLT 660 Query: 661 SLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQ 720 SLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQ Sbjct: 661 SLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQ 720 Query: 721 DQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR 780 DQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR Sbjct: 721 DQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR 780 Query: 781 IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQE 840 IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQE Sbjct: 781 IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQE 840 Query: 841 FYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAA 900 FYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAA Sbjct: 841 FYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAA 900 Query: 901 SKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQE 960 SKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQE Sbjct: 901 SKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQE 960 Query: 961 METQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPL 1020 METQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPL Sbjct: 961 METQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPL 1020 Query: 1021 AQKPSVAPRQDHQLDKKDGIYPAQLVNY 1048 AQKPSVAPRQDHQLDKKDGIYPAQLVNY Sbjct: 1021 AQKPSVAPRQDHQLDKKDGIYPAQLVNY 1048 >gi|48762942 huntingtin interacting protein-1-related [Homo sapiens] Length = 1068 Score = 1822 bits (4720), Expect = 0.0 Identities = 949/949 (100%), Positives = 949/949 (100%) Query: 100 GHLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEM 159 GHLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEM Sbjct: 120 GHLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEM 179 Query: 160 FDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHS 219 FDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHS Sbjct: 180 FDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHS 239 Query: 220 CLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHI 279 CLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHI Sbjct: 240 CLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHI 299 Query: 280 KPVVVIPEEAPEDEEPENLIEISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESL 339 KPVVVIPEEAPEDEEPENLIEISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESL Sbjct: 300 KPVVVIPEEAPEDEEPENLIEISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESL 359 Query: 340 KREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQL 399 KREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQL Sbjct: 360 KREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQL 419 Query: 400 RAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQ 459 RAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQ Sbjct: 420 RAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQ 479 Query: 460 QSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTE 519 QSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTE Sbjct: 480 QSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTE 539 Query: 520 QSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQ 579 QSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQ Sbjct: 540 QSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQ 599 Query: 580 GRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVS 639 GRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVS Sbjct: 600 GRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVS 659 Query: 640 RAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPAD 699 RAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPAD Sbjct: 660 RAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPAD 719 Query: 700 RLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEEL 759 RLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEEL Sbjct: 720 RLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEEL 779 Query: 760 GAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVT 819 GAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVT Sbjct: 780 GAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVT 839 Query: 820 TSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGK 879 TSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGK Sbjct: 840 TSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGK 899 Query: 880 YEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ 939 YEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ Sbjct: 900 YEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ 959 Query: 940 IEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPG 999 IEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPG Sbjct: 960 IEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPG 1019 Query: 1000 EEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLDKKDGIYPAQLVNY 1048 EEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLDKKDGIYPAQLVNY Sbjct: 1020 EEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLDKKDGIYPAQLVNY 1068 >gi|38045919 huntingtin interacting protein 1 [Homo sapiens] Length = 1037 Score = 842 bits (2176), Expect = 0.0 Identities = 477/1035 (46%), Positives = 660/1035 (63%), Gaps = 68/1035 (6%) Query: 14 EPVAGRRFLGSPRPAAEESGLEVCILSTHTVRPESPGGPAIWMHCKTSGVRDVPGGQRA- 72 + V+ + + + A +E CIL TH G W S V +P A Sbjct: 40 QTVSINKAINTQEVAVKEKHARTCILGTH----HEKGAQTFW-----SVVNRLPLSSNAV 90 Query: 73 LAWFSLEHCGVLVCLGRDIGAGQALDR--------------GHLHDRYGQLVNVYTKLLL 118 L W + C V L RD D GHL + YGQL ++Y KLL Sbjct: 91 LCW---KFCHVFHKLLRDGHPNVLKDSLRYRNELSDMSRMWGHLSEGYGQLCSIYLKLLR 147 Query: 119 TKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLN 178 TK+ +H K+P+FP L+++D L++A +DVNN FQLTVEMFDY++CEL L ++VF L+ Sbjct: 148 TKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNNFFQLTVEMFDYLECELNLFQTVFNSLD 207 Query: 179 TAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHSCLPADTLQGHRDRFHEQFH 238 + +VS ++GQCRLAPLIQVI DCSHLY YTVKLLFKLHSCLPADTLQGHRDRF EQF Sbjct: 208 MSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFMEQFT 267 Query: 239 SLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIKPVVVIPEEA--PEDE--- 293 L++ F R+S++ YFKRLIQIP+LPE PPNFLRASAL+EHI PVVVIP EA P+ E Sbjct: 268 KLKDLFYRSSNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEASSPDSEPVL 327 Query: 294 EPENLIEISTGPPAGEPVVVADLFDQTFGPP-----------NGSVKDDRDLQIESLKRE 342 E ++L+++ A + + + FD FG NG KD++D IE L RE Sbjct: 328 EKDDLMDMD----ASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEKDHLIERLYRE 383 Query: 343 VEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRAA 402 + L+++LE +K E+QR + QLK V+ LE +L EQ+ +Q+A D E LR EL +LR Sbjct: 384 ISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQ 443 Query: 403 QLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQ 462 + + E++Q E ERKA A E RY+KLKEK+SELV HA+LLRKNA+ KQ+++ +Q+Q Sbjct: 444 REDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQ 503 Query: 463 EEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSK 522 ++ R K++L +E++ + + K +E+ + LE LK+EL EL Q +L + QS+ Sbjct: 504 VDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSE 563 Query: 523 SELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRL 582 + ++ L E+D+L RE +L A + +++T+ L+ Sbjct: 564 ANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLA----------------- 606 Query: 583 AERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQ 642 S E+ + Q D++ +L G+ A ++QDA+++L++P + C S D+L+S Sbjct: 607 ----STEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVT 662 Query: 643 EALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLI 702 + LE+ +QYL D S L+ ++T +HL +D I +G T AP +PAD L Sbjct: 663 SISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLT 722 Query: 703 DTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAV 762 + C++ G L + L+++ +L + ++ +R L I +G+EL P+ LD++QEELG + Sbjct: 723 EACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDL 782 Query: 763 VDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTST 822 VDKEMAATSAAIE A RIE+M++++R +GVKLEVNERIL CT LM+AI++L+ S Sbjct: 783 VDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASK 842 Query: 823 SLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEE 882 LQ+EIVESGRG A+ +EFYAKNSRWTEGLISASKAVGWGAT +V+AAD VV GK+EE Sbjct: 843 DLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEE 902 Query: 883 LIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIED 942 L+VCSHEIAASTAQLVAASKVKA+K SP+L++LQ+ SR VN+ A VVAST SG+ QIE+ Sbjct: 903 LMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEE 962 Query: 943 RDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPGEEV 1002 D MDFS ++L ++K+QEM++QVRVLELE L+ ER +LGELRK+HY LAG + E Sbjct: 963 TDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGT 1022 Query: 1003 AIRPSTAPRSVTTKK 1017 P T VT K+ Sbjct: 1023 EASPPTLQEVVTEKE 1037 >gi|223029410 talin 1 [Homo sapiens] Length = 2541 Score = 109 bits (272), Expect = 2e-23 Identities = 156/756 (20%), Positives = 295/756 (39%), Gaps = 36/756 (4%) Query: 264 EGPPNFLRASALAEHIKPVVVIPEEAPED-----EEPENLIEISTGPPAGEPVVVADLFD 318 E N +A+ E ++ V + EA ED E + + G + L + Sbjct: 1781 EAGGNPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDE 1840 Query: 319 QTFGPPNGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQ 378 G P GS D + + + K ++ + K + + L +Q+ + G L + Sbjct: 1841 GPMGEPEGSFVDYQTTMVRTAKAIAVTVQEMVTKSNTSPEE-LGPLANQLTSDYGRLASE 1899 Query: 379 RKQKQKALVDNE---QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHS 435 K A + E ++H + +L G + + A + + Sbjct: 1900 AKPAAVAAENEEIGSHIKHRVQELGHGCAALVTKAGALQCSPSDAYTKKELIECARRVSE 1959 Query: 436 ELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVE-QVKRESELKLEEKSDQL 494 ++ HV A L N T +T +A + + F + RE + + + Sbjct: 1960 KVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFATAGTLNREGTETFADHREGI 2019 Query: 495 EK----LKRELEAKAGELARAQEALSHTEQSKSELSSRL-DTLSAEKDALSGAVRQREAD 549 K L + + A +QE L+ QS +RL D + +L + + Sbjct: 2020 LKTAKVLVEDTKVLVQNAAGSQEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQVV 2079 Query: 550 LLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQ-RLLDEQFAVLRGAA 608 L+ A V + L + ++ + G+ + S + + L + + A Sbjct: 2080 LINAVKDVAKALGDLISATKAAAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTVKAVEDEA 2139 Query: 609 AEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASAL 668 + L+ + L + C+ P S ++ + + A+ + + Sbjct: 2140 TKGTRALEATTEHIRQELAVFCSPEPPAKTSTPEDFIRMTKGITMATAKAVAAGNSCRQE 2199 Query: 669 -VAALTRFSHLAADTIINGGATSHLAPTDPAD---RLIDTCRECGARALELMGQLQ---- 720 V A S A ++ + P D R + REC LEL+ + Sbjct: 2200 DVIATANLSRRAIADMLRACKEAAYHPEVAPDVRLRALHYGRECANGYLELLDHVLLTLQ 2259 Query: 721 ------DQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAI 774 QQ H + V + ++Q + +K V E+ + + E+ +AAI Sbjct: 2260 KPSPELKQQLTGHSKR--VAGSVTELIQAAEAMKGTEW-VDPEDPTVIAENELLGAAAAI 2316 Query: 775 EDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG 834 E A +++E + +A+ + L E+IL + + A LV +++ Q+E+V G+ Sbjct: 2317 EAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAAATSALVKAASAAQRELVAQGKV 2376 Query: 835 AATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAAST 894 A + +W++GLISA++ V L EAA+ V E+LI + ++AAST Sbjct: 2377 GAIPANAL-DDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLISSAKQVAAST 2435 Query: 895 AQLVAASKVKANKHSPHLSRLQECSRTVNERAANVV-ASTKSGQEQIEDRDTMDFSGLSL 953 AQL+ A KVKA++ S + RLQ V + N+V A+ K+ + ++ +T+ + Sbjct: 2436 AQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAFEEQENETVVVKE-KM 2494 Query: 954 IKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHY 989 + Q + Q +L E+ LE R +L ++R+Q Y Sbjct: 2495 VGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQY 2530 Score = 37.4 bits (85), Expect = 0.075 Identities = 73/376 (19%), Positives = 131/376 (34%), Gaps = 88/376 (23%) Query: 647 AVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIING-----GATSHL------APT 695 AV+T+ LT ++ L+AAL + ++ GA S L A Sbjct: 576 AVTTISSN----LTEMSRGVKLLAALLEDEGGSGRPLLQAAKGLAGAVSELLRSAQPASA 631 Query: 696 DPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVR 755 +P L+ G + EL+ Q+ + H Q +L+ Sbjct: 632 EPRQNLLQAAGNVGQASGELLQQIGESDTDPHFQDALM---------------------- 669 Query: 756 QEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIR 815 +L V AA + +R ED Q + ++ + ++ L +CT ++ Sbjct: 670 --QLAKAVASAAAALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACTKVVAP-- 725 Query: 816 LLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKA----------VGWGATQ 865 +S Q+++VE+GR A + EG +SAS+A VG AT Sbjct: 726 --TISSPVCQEQLVEAGRLVA----------KAVEGCVSASQAATEDGQLLRGVGAAATA 773 Query: 866 LVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNER 925 + +A ++++ H V +H A A R + + T+ Sbjct: 774 VTQALNELLQH--------VKAHATGAGPA-----------------GRYDQATDTILTV 808 Query: 926 AANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELR 985 N+ +S E + + + L+ K + E + + K L A ++ Sbjct: 809 TENIFSSMGDAGEMVRQARILAQATSDLVNAIKADAEGESDLENSRKLLSAAKILADATA 868 Query: 986 KQHYVLAGASGSPGEE 1001 K GA+ P E Sbjct: 869 KMVEAAKGAAAHPDSE 884 >gi|156938343 talin 2 [Homo sapiens] Length = 2542 Score = 108 bits (269), Expect = 3e-23 Identities = 73/241 (30%), Positives = 130/241 (53%), Gaps = 12/241 (4%) Query: 754 VRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKA 813 V E+ + + E+ +A+IE A +++E + +A+ + L+ E+IL + + A Sbjct: 2297 VDPEDPTVIAETELLGAAASIEAAAKKLEQLKPRAKPKQADETLDFEEQILEAAKSIAAA 2356 Query: 814 IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKV 873 LV ++++ Q+E+V G+ + A + +W++GLISA++ V + L EAA+ Sbjct: 2357 TSALVKSASAAQRELVAQGKVGSIPANA-ADDGQWSQGLISAARMVAAATSSLCEAANAS 2415 Query: 874 VLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVV-AS 932 V E+LI + ++AASTAQL+ A KVKA++ S + RLQ V + N+V A+ Sbjct: 2416 VQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAA 2475 Query: 933 TKSGQEQIEDRD----TMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQH 988 K+ + +D D T G++ I ++EM L+ E+ LE R +L ++R+Q Sbjct: 2476 QKAAFGKADDDDVVVKTKFVGGIAQIIAAQEEM------LKKERELEEARKKLAQIRQQQ 2529 Query: 989 Y 989 Y Sbjct: 2530 Y 2530 Score = 35.8 bits (81), Expect = 0.22 Identities = 45/190 (23%), Positives = 80/190 (42%), Gaps = 25/190 (13%) Query: 763 VDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTST 822 + K + +A ++D V ED++ AR + V +DL+KA++ T+ Sbjct: 590 MSKGVKLLAALMDDEVGSGEDLLRAARTLAGAV------------SDLLKAVQ--PTSGE 635 Query: 823 SLQKEIVESGRGAATQQEFYAK------NSRWTEGLISASKAVGWGATQLVEAADKVVL- 875 Q + +G + + + R+ + L+S +KAV A LV A V Sbjct: 636 PRQTVLTAAGSIGQASGDLLRQIGENETDERFQDVLMSLAKAVANAAAMLVLKAKNVAQV 695 Query: 876 --HTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHL--SRLQECSRTVNERAANVVA 931 T +I + + A ST+QLVA +KV + S + +L E + V+ N V Sbjct: 696 AEDTVLQNRVIAAATQCALSTSQLVACAKVVSPTISSPVCQEQLIEAGKLVDRSVENCVR 755 Query: 932 STKSGQEQIE 941 + ++ E Sbjct: 756 ACQAATTDSE 765 >gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] Length = 2017 Score = 91.7 bits (226), Expect = 3e-18 Identities = 156/703 (22%), Positives = 270/703 (38%), Gaps = 151/703 (21%) Query: 333 DLQIESLKREVEMLRSELEKI----------KLEAQRYIAQLKSQVNALEGELEEQRKQK 382 +L + L+ E L+ L K+ KL+ R +AQL+ + +AL+G QR+ + Sbjct: 721 ELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGR---QRQAE 777 Query: 383 QKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHA 442 Q+A V E+ + L +LR Q + R+ E E L+++ L H + Sbjct: 778 QEATVAREE-QERLEELRLEQ------EVARQGLEGSLRVAEQAQEALEQQLPTLRHERS 830 Query: 443 ELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEK------------ 490 +L + A ++QL+ +Q E+ R ++ +E+ RE E +E Sbjct: 831 QLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAER 890 Query: 491 -----SDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQ 545 S++ +L+ E EA G L Q L+ E + +L + L K+ L+G + Sbjct: 891 EGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAG 950 Query: 546 READLLAAQSLVRETEAALSRE--QQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 603 ++A Q +A+L +E Q+ Q + E Q L E+ + + QRL E+ A Sbjct: 951 LRQQIIATQE-----KASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAA 1005 Query: 604 LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL---VSRAQEALDAVSTLEEGHAQYLT 660 R AE A LQ + + + L R + + L ++ Q+ D L E Q Sbjct: 1006 WRELEAERAQ-LQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQAL 1064 Query: 661 SLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQ 720 SL ++ T +++L+ T +LE+ Q + Sbjct: 1065 SLKESEK---------------------------TALSEKLMGTRHSLATISLEMERQKR 1097 Query: 721 DQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR 780 D Q+ + S V L EL+ D+R + +E AA + A E VRR Sbjct: 1098 DAQSRQEQDRSTVNA-------LTSELR----DLRAQ-------REEAAAAHAQE--VRR 1137 Query: 781 IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQE 840 +++ QAR + + L +L +RLL L++E++E+ R QE Sbjct: 1138 LQE---QARDLG-----KQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQE 1189 Query: 841 FYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAA 900 E+ A + Sbjct: 1190 ----------------------------------------------GREVQRQEAGELRR 1203 Query: 901 SKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQE 960 S + K L R E R+ ++A + S K E E + + + + + E Sbjct: 1204 SLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGE 1263 Query: 961 METQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPGEEVA 1003 + T ++ +E + LEA R L ELR+Q +L + G E+A Sbjct: 1264 LRTGLQEVERSR-LEARR-ELQELRRQMKMLDSENTRLGRELA 1304 Score = 70.5 bits (171), Expect = 8e-12 Identities = 149/703 (21%), Positives = 294/703 (41%), Gaps = 78/703 (11%) Query: 332 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 391 R LQ++ ++ E + L ++ + ++ +S+ ALE +L+ R + A+ +E Sbjct: 531 RQLQVQDMRGRYEASQDLLGTLR----KQLSDSESERRALEEQLQRLRDKTDGAMQAHED 586 Query: 392 LRHELAQLRAA------------------QLEGERSQGLREEAERKASATEARYNKLKEK 433 + E+ +LR+A Q + E + RE+ + + ++L+E+ Sbjct: 587 AQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEE 646 Query: 434 HSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQ 493 + V A + R+ + +QL + + +A+ ++ + + + ++ EK++ Sbjct: 647 QEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEV 706 Query: 494 LEKLKR------ELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQRE 547 E L + ELE +L RA+EA + S S+LS+ ++L+ +K L+ V Q E Sbjct: 707 AEALTKAEAGRVELELSMTKL-RAEEA--SLQDSLSKLSALNESLAQDKLDLNRLVAQLE 763 Query: 548 ADLLAAQSLVR--ETEAALSREQQRSSQEQGELQGRLAERESQEQGLR-----QRLLDEQ 600 + A Q R E EA ++RE+Q +E L+ +A R+ E LR Q L++Q Sbjct: 764 EEKSALQGRQRQAEQEATVAREEQERLEEL-RLEQEVA-RQGLEGSLRVAEQAQEALEQQ 821 Query: 601 FAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLT 660 LR ++ LQ+ +++L L + L +EA V LE A+ Sbjct: 822 LPTLRHERSQ----LQEQLAQLSRQL----SGREQELEQARREAQRQVEALERA-AREKE 872 Query: 661 SLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR-----ECGARALEL 715 +LA A +A + T+ L L + R E LE Sbjct: 873 ALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEA 932 Query: 716 MGQ--LQDQQALRHMQASLVRTPL--QGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 771 GQ L ++ L A L + + Q L +EL + L + E A + ++ AA Sbjct: 933 EGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAH- 991 Query: 772 AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRL----LVTTSTSLQKE 827 E+ ++R++ A + ++ ++ +L+ + L +LQ+E Sbjct: 992 ---EEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQE 1048 Query: 828 IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWG---ATQLVEAADKVVLHTGKYEELI 884 + G A ++ A + + +E + K +G AT +E + + E+ Sbjct: 1049 -RDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDR 1107 Query: 885 VCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIE-DR 943 + + + L A + A H+ + RLQE +R + ++ + + + + Q+ Sbjct: 1108 STVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLE 1167 Query: 944 DTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRK 986 D D L+++ +E Q ++ E ++ E +R GELR+ Sbjct: 1168 DARD-------GLRRELLEAQRKLRESQEGREVQRQEAGELRR 1203 Score = 70.5 bits (171), Expect = 8e-12 Identities = 181/788 (22%), Positives = 296/788 (37%), Gaps = 161/788 (20%) Query: 329 KDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVD 388 K D + E + V L SEL ++ + + A +V L+ + + KQ+ L + Sbjct: 1096 KRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLRE 1155 Query: 389 NEQLRHELAQLRAAQ-------LEGERSQGLREEAERK-----------------ASATE 424 E+LR +L L A+ LE +R LRE E + A E Sbjct: 1156 AEELRTQLRLLEDARDGLRRELLEAQRK--LRESQEGREVQRQEAGELRRSLGEGAKERE 1213 Query: 425 ARYNKLKEKHSELVHVHAE---LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKR 481 A +E S + +E L N D ++L + ++++ V + +L +++V+R Sbjct: 1214 ALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVER 1273 Query: 482 ---ESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDA 538 E+ +L+E Q++ L E ELA Q L+ E+++ E SR +TL + Sbjct: 1274 SRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKE--SRRETLGLRQRL 1331 Query: 539 LSGAV-----------------------RQREADLLAAQSLVRETE-------AALSREQ 568 L G R RE LL + R TE L + Sbjct: 1332 LKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKL 1391 Query: 569 QRSSQEQGELQGRLAERESQEQGL---------RQRLLDEQFAVLRGAAAEAAGI----- 614 + + E EL RL+ E + QGL ++R + Q LR A G+ Sbjct: 1392 EAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPS 1451 Query: 615 ----------LQDAVSK-----LDDPLHLRCT-----SSPDYLVSRAQEALDAVSTLEEG 654 +DA ++ L+ P L C+ SP S A LD + Sbjct: 1452 PAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDP-EAVRGA 1510 Query: 655 HAQYLTSLADAS-------ALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRE 707 ++L L A +AL R LA ATS A +L E Sbjct: 1511 LREFLQELRSAQRERDELRTQTSALNR--QLAEMEAERDSATSR------ARQLQKAVAE 1562 Query: 708 CGARALELMGQLQDQQA-LRHMQASLVRTPLQGILQLGQ-ELKPKSLDVRQEELGAVVDK 765 + G+L QA L + S+ R+ + L Q +SL + EL A +K Sbjct: 1563 SEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEK 1622 Query: 766 --EMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILN--------SCTDLMKAIR 815 +M A +E RR++++++ + S VKLE+ R L +D + Sbjct: 1623 ISKMKANETKLEGDKRRLKEVLDASE--SRTVKLELQRRSLEGELQRSRLGLSDREAQAQ 1680 Query: 816 LLVTTSTSLQKEIVESGRGAATQQEFYAK------NSRWTEGLI-----SASKAVGWGAT 864 L SLQ+++ +S A T Q + +EG + ++A+ + Sbjct: 1681 ALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSA 1740 Query: 865 QLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKV--KANKHSPHLSRLQECSRTV 922 L DK LH K L C H+ +L AA + +A K S S L E +T+ Sbjct: 1741 SLNSTRDK-NLHLQK--ALTACEHDRQVLQERLDAARQALSEARKQS---SSLGEQVQTL 1794 Query: 923 NERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM--- 979 A++ + Q++ L ++ +Q E + L + L+ ER Sbjct: 1795 RGEVADLELQRVEAEGQLQ----------QLREVLRQRQEGEAAALNTVQKLQDERRLLQ 1844 Query: 980 -RLGELRK 986 RLG L++ Sbjct: 1845 ERLGSLQR 1852 Score = 56.2 bits (134), Expect = 2e-07 Identities = 137/563 (24%), Positives = 220/563 (39%), Gaps = 82/563 (14%) Query: 392 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADT 451 LR L +LR+AQ E R+E + SA + +++ + +L + A++ Sbjct: 1511 LREFLQELRSAQRE-------RDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAES 1563 Query: 452 AKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARA 511 + + ++ V+ +LA Q E V+R SE + DQ+ L+R L+A EL + Sbjct: 1564 EE---ARRSVDGRLSGVQAELALQEESVRR-SERERRATLDQVATLERSLQATESELRAS 1619 Query: 512 QEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRS 571 QE +S + A + L G R+ + L A++S + E QR Sbjct: 1620 QEKIS--------------KMKANETKLEGDKRRLKEVLDASES------RTVKLELQRR 1659 Query: 572 SQEQGELQGR---LAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHL 628 S E GELQ L++RE+Q Q L+ R+ Q V + AG LQ V +L+ L Sbjct: 1660 SLE-GELQRSRLGLSDREAQAQALQDRVDSLQRQV--ADSEVKAGTLQLTVERLNGAL-- 1714 Query: 629 RCTSSPDYLVSRAQEAL-DAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGG 687 V ++ AL D V L E AQ SL TR +L + Sbjct: 1715 -------AKVEESEGALRDKVRGLTEALAQSSASLNS--------TRDKNLHLQKALT-- 1757 Query: 688 ATSHLAPTDPADRLIDTCRECGARALELMGQLQDQ-QALRHMQA--SLVRTPLQGILQLG 744 A H +D R+ + A + L +Q Q LR A L R +G LQ Sbjct: 1758 ACEH--DRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQL 1815 Query: 745 QELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERIL 804 +E+ L RQE A ++ T ++D R +++ + + A + ++ E E + Sbjct: 1816 REV----LRQRQEGEAAALN-----TVQKLQDERRLLQERLGSLQRALAQLEAEKRE-VE 1865 Query: 805 NSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGAT 864 S L K L T +++E + S A+ R L A + Sbjct: 1866 RSALRLEKDRVALRRTLDKVEREKLRSHEDTV---RLSAEKGRLDRTLTGAELELAEAQR 1922 Query: 865 QLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVK----ANKHSPHLSRLQECSR 920 Q+ + +VV+ + E+ A QL +V+ A + +E + Sbjct: 1923 QIQQLEAQVVVLEQSHSP---AQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAH 1979 Query: 921 TVNERAANVVASTKSGQEQIEDR 943 R ST GQ Q E R Sbjct: 1980 RQRVRGLEEQVSTLKGQLQQELR 2002 Score = 50.8 bits (120), Expect = 7e-06 Identities = 87/412 (21%), Positives = 162/412 (39%), Gaps = 52/412 (12%) Query: 364 LKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQ---LRAAQLEGERSQGLREEAERKA 420 L+ +++ +E L + R ++ + + + L Q L +LE + +GL ++ Sbjct: 86 LQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLVRQS---- 141 Query: 421 SATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVK 480 V + +L + A ++L Q+ Q+ A++ ++L ++ Q K Sbjct: 142 -----------------VELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYK 184 Query: 481 R---ESELKLEEKSDQLEKLK-------RELEAKAGELARAQEALSHTEQSKSELSSRLD 530 + E E +L E+S +LE+ + ++LE+ L Q+ + Q + L +LD Sbjct: 185 KRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLD 244 Query: 531 TLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQ 590 + ALS +R+ D + + EAA RE++ + RL Q Sbjct: 245 QAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVV 304 Query: 591 GLRQRLLDE-------QFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRA-- 641 G R RL+ E L G A + +Q+A L L L + + L +A Sbjct: 305 GFR-RLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALL 363 Query: 642 -----QEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTD 696 ++ D V ++ Q + S D + L A +T LA + D Sbjct: 364 QAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELG-LAVKRLEKQNLEKDQVNKD 422 Query: 697 PADRL--IDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQE 746 ++L +++ R ALE QQ LR + +++ G+ G E Sbjct: 423 LTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSE 474 Score = 50.1 bits (118), Expect = 1e-05 Identities = 70/286 (24%), Positives = 137/286 (47%), Gaps = 27/286 (9%) Query: 337 ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ--LRH 394 E +R+ ++++ KI L+ ++ ++L+ Q+ GELE+QR + + D E +R Sbjct: 164 EGQQRQAQLVQRLQGKI-LQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRL 222 Query: 395 ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAEL-LRKNADTAK 453 E Q R+A L + + LRE+ ++ SA +A +++ ++ EL R+ A + Sbjct: 223 EEEQQRSASL-AQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRRE 281 Query: 454 QLTVTQQSQEEVARV----KEQLAFQ--VEQVKRESELKLEEKSDQLEKLKRELEAKAGE 507 + + E +R+ ++ + F+ V +VK +E L + +L + R ++ Sbjct: 282 EESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLG 341 Query: 508 L--------ARAQEALSHTEQSKSELSSRL-DTLSAEKDALSGAVRQREADLLAAQSLVR 558 L +RA+ AL +++L +L D + EKD A +Q ++DL A R Sbjct: 342 LSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDL---AQQQMQSDLDKADLSAR 398 Query: 559 ETEAALS-REQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 603 TE L+ + ++ + E+ ++ L E+ + LR L EQ A+ Sbjct: 399 VTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLR---LQEQAAL 441 Score = 47.8 bits (112), Expect = 6e-05 Identities = 73/277 (26%), Positives = 110/277 (39%), Gaps = 86/277 (31%) Query: 356 EAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREE 415 EA++ + L QV L GE+ + Q+ +A +QLR L Q R+E Sbjct: 1779 EARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQ--------------RQE 1824 Query: 416 AERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQ 475 E A L Q+ Q+E ++E+L Sbjct: 1825 GE----------------------------------AAALNTVQKLQDERRLLQERLG-- 1848 Query: 476 VEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHT--EQSKSELSSRLDT-- 531 L+ QLE KRE+E A L + + AL T + + +L S DT Sbjct: 1849 ----------SLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVR 1898 Query: 532 LSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSS---------QEQGELQGRL 582 LSAEK L + E +L AQ +++ EA + +Q S Q+Q ELQ + Sbjct: 1899 LSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEV 1958 Query: 583 ---------AER--ESQEQGLRQRL--LDEQFAVLRG 606 ER E++E+ RQR+ L+EQ + L+G Sbjct: 1959 ERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKG 1995 Score = 36.6 bits (83), Expect = 0.13 Identities = 45/182 (24%), Positives = 77/182 (42%), Gaps = 28/182 (15%) Query: 335 QIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 394 Q+E+ KREVE LEK ++ +R + +++ + L + R +K +D Sbjct: 1856 QLEAEKREVERSALRLEKDRVALRRTLDKVERE--KLRSHEDTVRLSAEKGRLDR----- 1908 Query: 395 ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 454 L A+LE EA+R+ EA+ L++ HS A+L D +Q Sbjct: 1909 ---TLTGAELE-------LAEAQRQIQQLEAQVVVLEQSHSP-----AQL---EVDAQQQ 1950 Query: 455 LTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEA 514 QQ E + + Q +E +R ++ +Q+ LK +L+ EL R+ Sbjct: 1951 QLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQ---ELRRSSAP 2007 Query: 515 LS 516 S Sbjct: 2008 FS 2009 Score = 33.1 bits (74), Expect = 1.4 Identities = 71/304 (23%), Positives = 134/304 (44%), Gaps = 37/304 (12%) Query: 711 RALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQ----------EELG 760 +++EL QLQ++QA + + Q QL Q L+ K L ++ E G Sbjct: 140 QSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSG 199 Query: 761 AVVDKEMAAT--SAAIEDAVRRIEDMMNQARHAS----SGVKLEVNERILNSCTDLMKAI 814 + + + T S +E A+ R+E+ Q R AS + + E ++ ++ L + I Sbjct: 200 ELEQQRLRDTEHSQDLESALIRLEE--EQQRSASLAQVNAMLREQLDQAGSANQALSEDI 257 Query: 815 RLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEG----LISASKAVGWG--ATQLVE 868 R + T +KE+ R AA ++E + N+ ++ L+ + VG+ +++ Sbjct: 258 RKVTNDWTRCRKEL--EHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKM 315 Query: 869 AADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAAN 928 ++ +L G EL S + + L ++ ++ L + + E+ + Sbjct: 316 FTERDLLQLG--GELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRD 373 Query: 929 VVASTKS-GQEQIE-DRDTMDFS------GLSLIKLKKQEMETQVRVLELEKTLEA-ERM 979 V K Q+Q++ D D D S GL++ +L+KQ +E +L + LEA E + Sbjct: 374 KVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESL 433 Query: 980 RLGE 983 RL E Sbjct: 434 RLQE 437 >gi|21735548 centrosomal protein 2 [Homo sapiens] Length = 2442 Score = 90.9 bits (224), Expect = 6e-18 Identities = 167/715 (23%), Positives = 304/715 (42%), Gaps = 103/715 (14%) Query: 329 KDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVD 388 K + +++++ + E+E ++++ E+ + +A+ + Q++ + L E Q QK L D Sbjct: 884 KMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELAD 943 Query: 389 NEQLRHELAQ-LRAAQLEGERSQGLRE----EAERKASATEARYNK----LKEKHSELVH 439 Q L Q ++ +L+ + + G+ + EA+R+ ++ L+E+ S L+ Sbjct: 944 ASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQ 1003 Query: 440 VHAELLRKNADTAKQLTVTQQSQEEVAR-VKEQLAFQVEQVKRESELKLEEKS---DQLE 495 +L ++ D QL SQ V + V+E+L E + + EL+ E+ S +E Sbjct: 1004 DKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLME 1063 Query: 496 KLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQS 555 K +R L + + R QE LS Q E LSA+ + L V+++EAD LA ++ Sbjct: 1064 KEQRLLVLQEADSIRQQE-LSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEA 1122 Query: 556 -LVRETEAALSREQQRSSQ------EQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAA 608 L+ E EA+ EQQ + + +LQ RL ESQ + L ++Q G Sbjct: 1123 QLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEAL---AAEQQ----PGNQ 1175 Query: 609 AEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASAL 668 A+A L S L L C S P+ +S ++ +V LE SL L Sbjct: 1176 AQAQAQLASLYSALQQALGSVCESRPE--LSGGGDSAPSVWGLEPDQ-NGARSLFKRGPL 1232 Query: 669 VAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHM 728 + A L+A+ + + H + D R+ + +L +L D +A Sbjct: 1233 LTA------LSAEAVASALHKLH-QDLWKTQQTRDVLRD---QVQKLEERLTDTEA---- 1278 Query: 729 QASLVRTPLQGI-LQLGQELKPKS-LDVRQEELGAVVDKEMAATSAAIEDAVRRI----- 781 + S V T LQ + QL Q + KS + +Q L + + E+ T A+++ +RR Sbjct: 1279 EKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESEL-MELHETMASLQSRLRRAELQRM 1337 Query: 782 -------------EDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 828 E++ Q H + V V R S +++ ++ L+ E Sbjct: 1338 EAQGERELLQAAKENLTAQVEHLQAAV---VEARAQASAAGILEEDLRTARSALKLKNEE 1394 Query: 829 VES--GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVC 886 VES R A Q++ K ++ + + + L E ++V G+ +EL Sbjct: 1395 VESERERAQALQEQGELKVAQGK----ALQENLALLTQTLAEREEEVETLRGQIQEL-EK 1449 Query: 887 SHEIAASTAQLVAASKVKANK----HSPHLSRLQEC-------SRTVNERAANVVASTKS 935 E+ + +L++ K N+ + L++C V ER + + Sbjct: 1450 QREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQ 1509 Query: 936 GQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEK---TLEAERMRLGELRKQ 987 +E +DR+T Q + ++LELEK +E++R ++ +L+KQ Sbjct: 1510 IRELEKDRET-------------QRNVLEHQLLELEKKDQMIESQRGQVQDLKKQ 1551 Score = 79.3 bits (194), Expect = 2e-14 Identities = 116/537 (21%), Positives = 226/537 (42%), Gaps = 88/537 (16%) Query: 331 DRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN- 389 +RD +++S + ++E L+ + E + + +R +L Q ++ LE+QR ++ K L ++ Sbjct: 1627 ERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQ-VLEDQRTRQTKILEEDL 1685 Query: 390 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKL---------KEKHSELVHV 440 EQ++ L + R +L +R Q ++E AE ++A+ L KEK E Sbjct: 1686 EQIKLSLRE-RGRELTTQR-QLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQE 1743 Query: 441 HAELLRKNADTAKQ-------------LTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 487 H L++ D +Q L ++Q+ QE V L Q+++ + + ELK Sbjct: 1744 HIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVV-----LQQQLQEAREQGELKE 1798 Query: 488 EEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQRE 547 + QL++ +R L + EL Q+ + + + + D L + +++R Sbjct: 1799 QSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERH 1858 Query: 548 ADLLAAQSLVRETEAALS---REQQRSSQEQGELQGRLAERESQEQGLRQRLLDE----- 599 +L + R E L+ R Q + G+L+ E+E L+Q+ ++ Sbjct: 1859 GELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHE 1918 Query: 600 -QFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRA-----QEALDAVSTLEE 653 + L+ + +A +L++ +L+ +S +RA QEAL + Sbjct: 1919 VETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQ 1978 Query: 654 GHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARAL 713 G Q+L A+ S + A T + D +H + A R+ + Sbjct: 1979 GKEQHLLEQAELSRSLEASTATLQASLD-----ACQAHSRQLEEALRIQE---------- 2023 Query: 714 ELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAA 773 G++QDQ LR+ + V+ Q + Q +EL+ Q+E +++K +A Sbjct: 2024 ---GEIQDQD-LRYQED--VQQLQQALAQRDEELR------HQQEREQLLEKSLA----- 2066 Query: 774 IEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVE 830 +R+++ M Q + ER L +++R L T ++EI+E Sbjct: 2067 -----QRVQENMIQEKQNLG------QEREEEEIRGLHQSVRELQLTLAQKEQEILE 2112 Score = 72.0 bits (175), Expect = 3e-12 Identities = 156/736 (21%), Positives = 307/736 (41%), Gaps = 74/736 (10%) Query: 292 DEEPENLIEISTGPPAGEPVVVADLFD-QTFGPPNGSVKDDRDLQIESLKREVEMLRSEL 350 + + ++L E G + + ++ + LF+ Q K ++QI+++ + E+++ E+ Sbjct: 749 ERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEV 808 Query: 351 EKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH--ELAQLRAAQLEGER 408 +KLE +Q + + +A +L Q +Q+ K ++ ++ H E+ QLR + E ER Sbjct: 809 RCLKLELDTERSQAEQERDAAARQL-AQAEQEGKTALEQQKAAHEKEVNQLR-EKWEKER 866 Query: 409 SQGLREEAERKASATEARYN---KLKEKHSELVHVHAE-----------LLRKNADTAKQ 454 S +E A+ S + +LKE+ +E+ + A+ L + +T K+ Sbjct: 867 SWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKE 926 Query: 455 ----LTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKS----DQLEKLKRELEAKA- 505 L Q+Q+E+A +QL ++ Q + +LK +E + QL++ +REL+ A Sbjct: 927 RVSLLETLLQTQKELADASQQLE-RLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAAR 985 Query: 506 ---GELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 562 +LA QE S Q K +L +++ L ++ A + R E ++ Q +RET+ Sbjct: 986 QHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEV---QEKLRETQ- 1041 Query: 563 ALSREQQRSSQEQGELQGRLAERESQEQGLRQ--RLLDEQFAVLRGAAAEAAGILQDAVS 620 +R Q+ +E+ L L E+E + L++ + ++ + LR EA G ++ + Sbjct: 1042 EYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSA 1101 Query: 621 KLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAA 680 +++ D+L AQ LEE A ++T L A+L AA Sbjct: 1102 QMELLRQEVKEKEADFLAQEAQ-------LLEELEASHITE----QQLRASLWAQEAKAA 1150 Query: 681 DTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGI 740 + +T A++ + A+ L L QQAL + S R L G Sbjct: 1151 QLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSAL--QQALGSVCES--RPELSG- 1205 Query: 741 LQLGQELKPKSLDVRQEELGA-VVDKE----MAATSAAIEDAVRRIEDMM---NQARHAS 792 G + P + ++ GA + K A ++ A+ A+ ++ + Q R Sbjct: 1206 ---GGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVL 1262 Query: 793 SGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGL 852 ++ ER+ ++ + + L L + E + Q ++ E + Sbjct: 1263 RDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETM 1322 Query: 853 ISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHL 912 S + Q +EA + EL+ + E + + + A+ V+A + Sbjct: 1323 ASLQSRLRRAELQRMEAQGE--------RELLQAAKENLTAQVEHLQAAVVEARAQASAA 1374 Query: 913 SRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVL-ELE 971 L+E RT +S +E+ + ++ K ++ + + L E E Sbjct: 1375 GILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAERE 1434 Query: 972 KTLEAERMRLGELRKQ 987 + +E R ++ EL KQ Sbjct: 1435 EEVETLRGQIQELEKQ 1450 Score = 70.1 bits (170), Expect = 1e-11 Identities = 75/333 (22%), Positives = 150/333 (45%), Gaps = 39/333 (11%) Query: 330 DDRDLQIESLKREVEMLRSEL---EKIKLEAQRYIAQLKSQ---VNALEGELEEQRKQKQ 383 + +D IES + +V+ L+ +L E + LE + +++ Q + LEG+ E QR Sbjct: 1532 EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALT 1591 Query: 384 KALVDNEQLRHELAQLRAAQLEGERSQG--LREEAERKASATEARYNKLKEKHSELVHVH 441 +D E+ EL Q +++Q+ S L E + + +++ +++E + H+ Sbjct: 1592 HLTLDLEERSQEL-QAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLT 1650 Query: 442 AELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVK-----RESELK-----LEEKS 491 +L R++ + Q Q +++ R + L +EQ+K R EL ++E++ Sbjct: 1651 QDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERA 1710 Query: 492 DQ-----------LEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALS 540 ++ LE +K L K E+ QE + ++ K +L +L L + S Sbjct: 1711 EEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETS 1770 Query: 541 GAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQ------ 594 + QRE +++ Q ++E ++Q + E Q LA+R+ + + L+Q Sbjct: 1771 LLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQ 1830 Query: 595 ---RLLDEQFAVLRGAAAEAAGILQDAVSKLDD 624 + E+ L+GA +A L++ +L D Sbjct: 1831 GQEERVKEKADALQGALEQAHMTLKERHGELQD 1863 Score = 67.4 bits (163), Expect = 7e-11 Identities = 78/353 (22%), Positives = 152/353 (43%), Gaps = 46/353 (13%) Query: 337 ESLKREVEMLRSELEKIKLEAQRYIAQLKSQV---NALEGELEEQRKQKQKALVDNEQLR 393 E+L + L +L +++ E Q +++++ NAL+ +L E K+++ N L Sbjct: 606 EALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLE 665 Query: 394 HEL--AQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADT 451 +L A+ A+L+ + E+ E + +E+R+ + + ++L +H E R+ Sbjct: 666 AQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQ-EAATTQLEQLHQEAKRQEEVL 724 Query: 452 AKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARA 511 A+ + Q +E + R K L +++ V+R+ + + ++QL+ L E L A Sbjct: 725 ARAV----QEKEALVREKAALEVRLQAVERDRQ----DLAEQLQGLSSAKELLESSLFEA 776 Query: 512 QEALSHTEQSKSELSSRLDTLSAEKDALSGAVR-------------QREADLLAAQSLVR 558 Q+ S E +K +L ++ T++ K+ + G VR ++E D A Q Sbjct: 777 QQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQA 836 Query: 559 ETEAALSREQQRSSQE-----------------QGELQGRLAERESQEQGLRQRLLDEQ- 600 E E + EQQ+++ E Q EL L E ++ L RL ++Q Sbjct: 837 EQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQT 896 Query: 601 -FAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLE 652 ++ E + A+ ++ S + L+ +E DA LE Sbjct: 897 EMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLE 949 Score = 60.5 bits (145), Expect = 8e-09 Identities = 137/711 (19%), Positives = 301/711 (42%), Gaps = 78/711 (10%) Query: 324 PNGSVKDD--RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQ 381 PNGS + D Q+ L + + ELEK E + + QLKSQ + + EL+++ + Sbjct: 232 PNGSGRMDGREPAQLLLLLAKTQ----ELEKEAHERSQELIQLKSQGDLEKAELQDRVTE 287 Query: 382 KQKALVDNEQLRHELAQLRAAQ------LEGERSQGLREEAERKASATEARYNKLKEKHS 435 L +++ + ++ A LE ++ + EA +A E + + L++ Sbjct: 288 LSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLS-LQQVIK 346 Query: 436 ELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLE 495 ++ V E D Q + + S E + + Q +Q +++ L L Sbjct: 347 DITQVMVE----EGDNIAQGSGHENSLELDSSIFSQFDYQ------DADKALTLVRSVLT 396 Query: 496 KLKRELEAKAGELARAQEALSHTEQSKSE-------LSSRLDTLSAEKDALSGAV--RQR 546 + ++ ++ +LA QEA++ +Q + L RL L+ E+D L+G Q Sbjct: 397 RRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQG 456 Query: 547 EADLLAAQ-SLVRETEAALSREQQRSSQE---------QGELQGRLAERESQEQ------ 590 E D L+ + L+++ L ++ + QE + +LQG A+ + +EQ Sbjct: 457 EVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHL 516 Query: 591 GLRQR-LLDEQFAVLRGAAAEAAG---ILQDAV--SKLDDPLHLRCTSSPDYLVSRAQEA 644 +R+R L E L +E+ L++A+ S L+ L + + ++RA+++ Sbjct: 517 AVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQS 576 Query: 645 LDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDT 704 + +S+ E + L A+ ++AL LA D + G L + ++ + + Sbjct: 577 IAELSSSENTLKTEVADLRAAAVKLSALN--EALALDKV---GLNQQLLQLEEENQSVCS 631 Query: 705 CRECGARALELMGQLQDQQALRHMQA-----SLVRTPLQGILQLGQELKPKSLDVRQEEL 759 E +A + Q+ +A + +A + + LQ + G EL+ D+++E+ Sbjct: 632 RMEAAEQARNAL-QVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEK- 689 Query: 760 GAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVT 819 + K+++ + E A ++E + +A+ + V E+ + A+ + + Sbjct: 690 -EEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEK--EALVREKAALEVRLQ 746 Query: 820 TSTSLQKEIVESGRGAATQQEFYAKN---SRWTEGLISASKAVGWGATQLVEAADKVVLH 876 ++++ E +G ++ +E + ++ +I +K Q V A +V+ Sbjct: 747 AVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQG 806 Query: 877 TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSG 936 + +L + + A + AA ++ + + Q+ + +E+ N + Sbjct: 807 EVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQ--KAAHEKEVNQLREKWEK 864 Query: 937 QEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQ 987 + ++ +L L++++ME ++R+ E + +EA + + E R Q Sbjct: 865 ERSWHQQEL----AKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQ 911 Score = 57.8 bits (138), Expect = 5e-08 Identities = 87/371 (23%), Positives = 143/371 (38%), Gaps = 110/371 (29%) Query: 328 VKDDRDLQIESLKREV---EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQK 384 +KD + Q++ L R+V +L S+ E+ + Q+ + + + Q E L+ Q + Q+ Sbjct: 1751 LKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQR 1810 Query: 385 ALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASAT----EARYNKLKEKHSELV-- 438 AL +Q +L A Q E +++QG E + KA A E + LKE+H EL Sbjct: 1811 ALAQRDQ------ELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDH 1864 Query: 439 ----------------------HVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQV 476 V +L ++ + K L QQ E A+ E + Sbjct: 1865 KEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRAL 1924 Query: 477 EQVKRESELKLEEKSDQLEKLKRE--------------LEAKAGELARAQEALSHTEQ-- 520 + +++ L+E+ +LE L+ E EA L +A AL EQ Sbjct: 1925 QDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHL 1984 Query: 521 -SKSELSSRLD----TLSAEKDA--------------------------------LSGAV 543 ++ELS L+ TL A DA L A+ Sbjct: 1985 LEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQAL 2044 Query: 544 RQREADL--------LAAQSLVRETEAALSREQQRSSQEQ------------GELQGRLA 583 QR+ +L L +SL + + + +E+Q QE+ ELQ LA Sbjct: 2045 AQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLA 2104 Query: 584 ERESQEQGLRQ 594 ++E + LR+ Sbjct: 2105 QKEQEILELRE 2115 Score = 55.5 bits (132), Expect = 3e-07 Identities = 77/338 (22%), Positives = 130/338 (38%), Gaps = 54/338 (15%) Query: 322 GPPNGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQ-----LKSQVNALEGELE 376 G N + +L + + R+EL++++ + +R + Q L +QV L+ + Sbjct: 1306 GKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVV 1365 Query: 377 EQRKQKQKALVDNEQLRHELAQLRA----AQLEGERSQGLREEAERKASATEARYNKLK- 431 E R Q A + E LR + L+ + E ER+Q L+E+ E K + +A L Sbjct: 1366 EARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLAL 1425 Query: 432 ----------------------EKHSELVHVHAELLRKNADTAKQLTVTQQSQ----EEV 465 EK E+ ELL + Q QQ Q E+ Sbjct: 1426 LTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKC 1485 Query: 466 ARVKEQLAFQVEQ------VKRESELKLEEKSD-----------QLEKLKRELEAKAGEL 508 V E L V++ V+RE +LE+ + +LEK + +E++ G++ Sbjct: 1486 RSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQV 1545 Query: 509 ARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQ 568 ++ L E EL + ++ + QRE +A L + E Q Sbjct: 1546 QDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQ 1605 Query: 569 QRSSQ-EQGELQGRLAERESQEQGLRQRLLDEQFAVLR 605 +SSQ E + RE QE+ + EQ L+ Sbjct: 1606 AQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQ 1643 Score = 41.6 bits (96), Expect = 0.004 Identities = 50/199 (25%), Positives = 88/199 (44%), Gaps = 18/199 (9%) Query: 331 DRDLQIESLKREVEMLRSELEKIKLEA--QRYIAQLKS---------QVNALEGELEEQR 379 +RD + + L+ E+E+ R LEK +L + A+L S +V+ +E E Sbjct: 2203 ERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDG 2262 Query: 380 KQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVH 439 +KQ + + R E Q A+LE +RS+ R + +++ + + K K + Sbjct: 2263 MEKQ-----SWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRA 2317 Query: 440 VHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKR 499 A L + TA T ++ + K Q E V +++L LE K Q + + R Sbjct: 2318 AQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQ-DYITR 2376 Query: 500 ELEAKAGELARAQEALSHT 518 + + ELA +LSH+ Sbjct: 2377 SAQT-SRELAGLHHSLSHS 2394 >gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] Length = 1976 Score = 84.0 bits (206), Expect = 7e-16 Identities = 163/797 (20%), Positives = 320/797 (40%), Gaps = 102/797 (12%) Query: 289 APEDEEPENLIEISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESLKREVEMLRS 348 A E+E+ +NL +I + V+++DL ++R + E ++E+E + Sbjct: 1016 AEEEEKAKNLAKIRNK----QEVMISDL-------------EERLKKEEKTRQELEKAKR 1058 Query: 349 ELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALV--DNEQLRHELAQLRAAQLEG 406 +L+ + Q IA+L++Q++ L+ +L ++ ++ Q AL D+E L A +L+ Sbjct: 1059 KLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQA 1118 Query: 407 ERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVA 466 + ++ + KAS +A K ++ EL + EL TA Q + + ++EVA Sbjct: 1119 QIAELQEDFESEKASRNKAEKQK-RDLSEELEALKTELEDTLDTTAAQQELRTKREQEVA 1177 Query: 467 RVKEQL-------AFQVEQVKRESELKLEEKSDQLEKLKR-------------------- 499 +K+ L Q++ +++ LEE S+QLE+ KR Sbjct: 1178 ELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELA 1237 Query: 500 -----------ELEAKAGEL-ARAQE---ALSHTEQSKSELSSRLDTLSAEKDALSGAVR 544 E E K +L A+ QE +S ++ + EL+ + L E D +S + Sbjct: 1238 CEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLE 1297 Query: 545 QRE-------ADLLAAQSLVRETEAALSREQQRS------SQEQGELQGRLAERESQEQG 591 + E D + +S +++T+ L E ++ ++ E + L E++ +E+ Sbjct: 1298 EAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEE 1357 Query: 592 LRQRLLDEQFAVLRGAAAEAAGILQDAVSKLD--DPLHLRCTSSPDYLVSRAQEALDAVS 649 R+ L++Q L+ A+ + D + ++ + + + L R +E A Sbjct: 1358 ARKN-LEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYD 1416 Query: 650 TLE------EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLID 703 LE + LT D VA+ D ++ + + DR Sbjct: 1417 KLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEA 1476 Query: 704 TCRECGARALELMGQLQDQQALR---HMQASLVRTPLQGILQLGQEL--KPKSLDVRQEE 758 RE +AL L L++ + Q +R ++ ++ ++ L+ + Sbjct: 1477 EAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRA 1536 Query: 759 LGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLV 818 L V+ EM +ED ++ ED + +K + + + RLL+ Sbjct: 1537 LEQQVE-EMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI 1595 Query: 819 TTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTG 878 L+ E+ + + A K + L + +A ++++ K+ Sbjct: 1596 KQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK 1655 Query: 879 KYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQ-ECSRTVNERAANVVASTKSGQ 937 Y+ + E AS ++ A SK K L L+ E + E A++ A + Q Sbjct: 1656 DYQREL---EEARASRDEIFAQSKESEKK----LKSLEAEILQLQEELASSERARRHAEQ 1708 Query: 938 E--QIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGAS 995 E ++ D T SG S + +K+ +E R+ +LE+ LE E+ + L + Sbjct: 1709 ERDELADEITNSASGKSALLDEKRRLE--ARIAQLEEELEEEQSNMELLNDRFRKTTLQV 1766 Query: 996 GSPGEEVAIRPSTAPRS 1012 + E+A S A +S Sbjct: 1767 DTLNAELAAERSAAQKS 1783 Score = 76.3 bits (186), Expect = 1e-13 Identities = 118/515 (22%), Positives = 213/515 (41%), Gaps = 72/515 (13%) Query: 336 IESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHE 395 ++ + E E R LEK L Q +A K +V+ G +E + K+K L D E L Sbjct: 1348 LQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQR 1407 Query: 396 LAQLRAAQLEGERSQG-LREEAE----------RKASATEARYNK----LKEKHSELVHV 440 L + A + E+++ L++E + + AS E + K L E+ S Sbjct: 1408 LEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARY 1467 Query: 441 HAELLRKNADTAKQLTVT---QQSQEEVARVKEQLAFQVEQVKRESELKLEEKSD----- 492 E R A+ ++ T ++ EE KE+ Q +Q++ + E + K D Sbjct: 1468 AEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNV 1527 Query: 493 -QLEKLKRELEAKAGE----LARAQEALSHTEQSKSELSSRLDTLSA--EKDALSGAVRQ 545 +LEK KR LE + E L ++ L TE +K L + + A E+D + + Sbjct: 1528 HELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQN 1587 Query: 546 READLLAAQSLVRETEAALSREQQRSS---QEQGELQGRLAERESQEQGLRQRLLDEQFA 602 E L + VRE EA L E+++ + + +++ L + E+Q + + DE Sbjct: 1588 EEKKRLLIKQ-VRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAAN-KARDEVIK 1645 Query: 603 VLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSL 662 LR A+ ++D +L++ +S D + ++++E+ + +LE Q L Sbjct: 1646 QLRKLQAQ----MKDYQRELEE-----ARASRDEIFAQSKESEKKLKSLEAEILQLQEEL 1696 Query: 663 ADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQ 722 A + + AD I N + L+D R AR +L +L+++ Sbjct: 1697 ASSERARRHAEQERDELADEITNSASGK--------SALLDEKRRLEARIAQLEEELEEE 1748 Query: 723 QALRHMQASLVRTPLQGILQLGQEL-------------------KPKSLDVRQEELGAVV 763 Q+ + R + L EL + K L + +EL V Sbjct: 1749 QSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAV 1808 Query: 764 DKEMAATSAAIEDAVRRIEDMMNQ-ARHASSGVKL 797 + AT +A+E + ++E+ + Q A+ ++ KL Sbjct: 1809 KSKFKATISALEAKIGQLEEQLEQEAKERAAANKL 1843 Score = 72.0 bits (175), Expect = 3e-12 Identities = 86/345 (24%), Positives = 153/345 (44%), Gaps = 34/345 (9%) Query: 330 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 389 +DR + S E E L KI+ + + I+ L+ ++ E +E K K+K + Sbjct: 1005 EDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGET 1064 Query: 390 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 449 L+ ++A+L+ AQ++ + Q ++E E + + L E L KN Sbjct: 1065 TDLQDQIAELQ-AQIDELKLQLAKKEEELQGA---------------LARGDDETLHKN- 1107 Query: 450 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKR-ESELKLEEKSDQLEKLKRELEAKAGEL 508 L V ++ Q ++A ++E F+ E+ R ++E + + S++LE LK ELE Sbjct: 1108 ---NALKVVRELQAQIAELQED--FESEKASRNKAEKQKRDLSEELEALKTELEDTLDTT 1162 Query: 509 ARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQ 568 A QE + EQ +EL L+ + +A +RQR A A + L + E A + Sbjct: 1163 AAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHA--TALEELSEQLEQAKRFKA 1220 Query: 569 QRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHL 628 +QG E +++E ++L + A + +Q+ +K+ + L Sbjct: 1221 NLEKNKQG------LETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRL 1274 Query: 629 RCTSSPDYLVSRAQEALDAVST-LEEGHAQYLTSLADASALVAAL 672 R + S+ Q LD VST LEE + + DA++L + L Sbjct: 1275 RVELAEK--ASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQL 1317 Score = 62.0 bits (149), Expect = 3e-09 Identities = 59/283 (20%), Positives = 132/283 (46%), Gaps = 15/283 (5%) Query: 335 QIESLKREVEMLRSELEKI---KLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 391 Q++ +RE+E R+ ++I E+++ + L++++ L+ EL + ++ A + ++ Sbjct: 1653 QMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDE 1712 Query: 392 LRHEL---AQLRAAQLEGERS-----QGLREEAERKASATEARYNKLKEKHSELVHVHAE 443 L E+ A ++A L+ +R L EE E + S E ++ ++ ++ ++AE Sbjct: 1713 LADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAE 1772 Query: 444 LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEA 503 L + + K QQ + + +K +L VK + + + ++ +L+ +LE Sbjct: 1773 LAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQ 1832 Query: 504 KAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAA 563 +A E A A + + TE+ E+ +++ D + + A + + L R+ E A Sbjct: 1833 EAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARM---KQLKRQLEEA 1889 Query: 564 LSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRG 606 E R++ + +LQ L + +GL + + + + RG Sbjct: 1890 -EEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRG 1931 Score = 61.2 bits (147), Expect = 5e-09 Identities = 145/707 (20%), Positives = 287/707 (40%), Gaps = 95/707 (13%) Query: 334 LQIES-LKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGE---LEEQRKQKQKALVD- 388 LQ E+ L E E +R+ L K E + + L+S+V E L+ ++K+ Q + D Sbjct: 896 LQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDL 955 Query: 389 NEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNK-LKEKH--SELVHVHAELL 445 EQL E + QLE ++ ++ E + E + +K +KEK + + + L Sbjct: 956 EEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQL 1015 Query: 446 RKNADTAKQLTVTQQSQ-------EEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLK 498 + + AK L + Q EE + +E+ ++E+ KR+ + + + DQ+ +L+ Sbjct: 1016 AEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQ 1075 Query: 499 RELEAKAGELARAQE------------------ALSHTEQSKSELSSRLDTLSAEKDALS 540 +++ +LA+ +E AL + +++++ + +EK + + Sbjct: 1076 AQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRN 1135 Query: 541 GAVRQR---EADLLAAQSLVRETEAALSREQQ---RSSQEQGELQGRLAE----RESQEQ 590 A +Q+ +L A ++ + +T + +Q+ + QE EL+ L E E+Q Q Sbjct: 1136 KAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQ 1195 Query: 591 GLRQR---LLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDA 647 +RQR L+E L A A + ++ D L C + L Sbjct: 1196 DMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELAC----------EVKVLQQ 1245 Query: 648 VSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRE 707 V E + L A L A ++ L + + A+ D L++ + Sbjct: 1246 VKAESEHKRKKLD--AQVQELHAKVSEGDRLRVE--LAEKASKLQNELDNVSTLLEEAEK 1301 Query: 708 CGAR----ALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAV- 762 G + A L QLQD Q L + I QL +E SL +QEE Sbjct: 1302 KGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEE--KNSLQEQQEEEEEAR 1359 Query: 763 --VDKEMAATSAAIEDAVRRIEDMMNQARHASSGVK--LEVNERILNSCTDLMKAIRLLV 818 ++K++ A + + D ++++D + K L+ E + + A L Sbjct: 1360 KNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLE 1419 Query: 819 TTSTSLQKEI------VESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADK 872 T LQ+E+ ++ R A+ E K + + L++ K++ + + E D+ Sbjct: 1420 KTKNRLQQELDDLTVDLDHQRQVASNLE---KKQKKFDQLLAEEKSI---SARYAEERDR 1473 Query: 873 VVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVAS 932 + E + +A + + + A + ++ + +++ + ++ NV Sbjct: 1474 AEAEAREKETKAL---SLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHEL 1530 Query: 933 TKSG---QEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEA 976 KS ++Q+E+ T L +L+ + T+ L LE ++A Sbjct: 1531 EKSKRALEQQVEEMRT------QLEELEDELQATEDAKLRLEVNMQA 1571 Score = 59.3 bits (142), Expect = 2e-08 Identities = 72/307 (23%), Positives = 131/307 (42%), Gaps = 40/307 (13%) Query: 334 LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN---- 389 LQ+ + E++ EL K+K + + +EGELEE ++ Q+ L + Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTK-----------VEGELEEMERKHQQLLEEKNILA 893 Query: 390 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 449 EQL+ E A+ R ++E E E+R + +E++ L + ++ Sbjct: 894 EQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQ 953 Query: 450 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVK----RESELKLEEKSDQLEKLKRELEAKA 505 D +QL +EE AR K QL + K E L LE+++ + K K+ +E + Sbjct: 954 DLEEQL-----DEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRI 1008 Query: 506 GE----LARAQEALSHTEQSK-------SELSSRLDTLSAEKDALSGAVRQREADLLAAQ 554 E LA +E + + + S+L RL + L A R+ + + Q Sbjct: 1009 AECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQ 1068 Query: 555 SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGI 614 + E +A + + + ++++ ELQG LA + + L V+R A+ A + Sbjct: 1069 DQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNAL-----KVVRELQAQIAEL 1123 Query: 615 LQDAVSK 621 +D S+ Sbjct: 1124 QEDFESE 1130 >gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] Length = 2115 Score = 81.3 bits (199), Expect = 5e-15 Identities = 147/705 (20%), Positives = 278/705 (39%), Gaps = 80/705 (11%) Query: 336 IESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQ----RKQKQKALVDNEQ 391 I L+ + L E+++ +Q + A+L +QV +L EL ++Q Q+ +Q Sbjct: 468 ITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQ 527 Query: 392 LRHELAQL-RAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNAD 450 + + AQL + Q + + SQGLR + E+ +S+ LK+K +L V + D Sbjct: 528 AKEKQAQLAQTLQQQEQASQGLRHQVEQLSSS-------LKQKEQQLKEVAEKQEATRQD 580 Query: 451 TAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELAR 510 A+QL + +E R ++ Q+E +++E KLE QL+ ++ Sbjct: 581 HAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDS------- 633 Query: 511 AQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQR 570 AQ +++ ++ K+ELS +++ L A V + AQ+ V E E L EQQ+ Sbjct: 634 AQTSVTQAQREKAELSRKVEELQA-------CVETARQEQHEAQAQVAELELQLRSEQQK 686 Query: 571 SSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRC 630 +++++ R+A+ + Q Q Q L E V +G+ E DA+ + RC Sbjct: 687 ATEKE-----RVAQEKDQLQEQLQ-ALKESLKVTKGSLEEEKRRAADALEE-----QQRC 735 Query: 631 TSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA----LVAALTRF--SHLAADTII 684 S E +L E H + L + A L A L + +H A ++ Sbjct: 736 IS----------ELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVL 785 Query: 685 NGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ-------ALRHMQASLVRTPL 737 +A A+ C + + +D Q A+ Q ++ Sbjct: 786 RRELAEAMAAQHTAE---SECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEEC 842 Query: 738 QGILQLGQELKPK--SLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGV 795 + Q QE K K ++ E + E+A A + A++++++ +A+ + + Sbjct: 843 EKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDL 902 Query: 796 K------LEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESG-RGAATQQEFYAKNSRW 848 ++ + T + KA T S L KE +G R +E + Sbjct: 903 STLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCS 962 Query: 849 TEGLISASKAVGWGATQLVEAADKVVLHT--GKYEELIVCSHEIAASTAQLVAASKVKAN 906 T+ + A + +E ++ + + EE E+A T + A A Sbjct: 963 TQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLAL 1022 Query: 907 KHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVR 966 + + +NE+ ++ + +++ D L KL+ E Sbjct: 1023 EKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKD---QELAKLRGLEAAQIKE 1079 Query: 967 VLELEKTLEAERMRLGELRKQHYVLAGASGSPGEEVAIRPSTAPR 1011 + EL +T++ + +L + K+H A SG+ E T P+ Sbjct: 1080 LEELRQTVKQLKEQLAKKEKEH---ASGSGAQSEAAGRTEPTGPK 1121 Score = 76.6 bits (187), Expect = 1e-13 Identities = 148/695 (21%), Positives = 273/695 (39%), Gaps = 57/695 (8%) Query: 332 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 391 +D ++ LK++ + +++L + + ++ L+ QV L L+++ +Q ++ E Sbjct: 517 QDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEA 576 Query: 392 LRHELAQLRAAQLEGERSQGLREE--AERKASATEARYNKLKEKHSELVHVHAELLRKN- 448 R + AQ A E ER LRE A ++ A E KEK ++L + +L N Sbjct: 577 TRQDHAQQLATAAE-EREASLRERDAALKQLEALE------KEKAAKLEILQQQLQVANE 629 Query: 449 ADTAKQLTVTQQSQE--EVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAG 506 A + Q +VTQ +E E++R E+L VE ++E E Q+ +L+ +L ++ Sbjct: 630 ARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQH----EAQAQVAELELQLRSEQQ 685 Query: 507 ELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSR 566 + + +Q + +L + ++L K +L R+ L Q + E +A Sbjct: 686 KATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRS 745 Query: 567 EQQRSSQEQGELQGRLAERESQEQGLRQ--RLLDEQFAVLRGAAAEAAGILQDAVSKLDD 624 ++ +E+ EL+ A R+ E L+Q + VLR AEA A S+ + Sbjct: 746 LVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQ 805 Query: 625 PLHLRCTSSPDYLVSRAQEAL------DAVSTLEEGHAQYLTSLADASALVAALTRFSHL 678 + Y S+ +EA + + TL+E + L +A VA + S L Sbjct: 806 LVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSEL 865 Query: 679 AADTIINGGATSHLAPTDPADRLIDTCRECGARALEL---MGQLQDQQALRHMQAS---- 731 N A H R + +E RA +L + LQ++ A + + Sbjct: 866 QISRQQNELAELHANLA----RALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLET 921 Query: 732 LVRTPLQGILQLGQEL--KPKSLDVRQEE-LGAVVDKEMAATSAAIEDAVRRIEDMMNQA 788 LVR + +EL +P RQ E L ++ +T AA++ R E M N+ Sbjct: 922 LVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNEL 981 Query: 789 RHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRW 848 + + ++ + RL + +E A + + Sbjct: 982 ERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQ 1041 Query: 849 TEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKH 908 + +A+ T+ GK +EL A L AA + + Sbjct: 1042 RVEFATLQEALAHALTE----------KEGKDQEL--------AKLRGLEAAQIKELEEL 1083 Query: 909 SPHLSRLQE-CSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRV 967 + +L+E ++ E A+ A +++ ++ + KL++Q + Q + Sbjct: 1084 RQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQA 1143 Query: 968 LELEKTLEAERMRLGELRKQHYVLAGASGSPGEEV 1002 LE++LEAER E L G +E+ Sbjct: 1144 DSLERSLEAERASRAERDSALETLQGQLEEKAQEL 1178 Score = 75.1 bits (183), Expect = 3e-13 Identities = 160/748 (21%), Positives = 289/748 (38%), Gaps = 150/748 (20%) Query: 324 PNGSVKDDRDLQIESLKR----------EVEMLRSELEKIKLEAQRYIAQLKSQVNAL-- 371 P G + Q+ LK+ E+E+ +E K+ E IA ++ +++ L Sbjct: 204 PMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLAL 263 Query: 372 -----------EGELEEQR--------------KQKQKALVDNEQLRHELAQLRAAQLEG 406 ELEE R KQ Q + Q+ ++ QL ++ G Sbjct: 264 LNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQL--SEENG 321 Query: 407 ERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQS----- 461 + S LRE A +A N+L E+HS+ E L K A K+L+ Q Sbjct: 322 DLSFKLREFASHLQQLQDA-LNELTEEHSKATQ---EWLEKQAQLEKELSAALQDKKCLE 377 Query: 462 ------QEEVARVKEQLA-----------------FQVEQVKRES--------------- 483 Q ++++++E L+ Q+E +K+E+ Sbjct: 378 EKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVE 437 Query: 484 ---------ELKL-------EEKSDQLEKLKRELEAKAGELARAQEALSHTEQSK-SELS 526 E KL EE+ QL L +L++ L++A+E L Q+ + L+ Sbjct: 438 MLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLT 497 Query: 527 SRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSRE-QQRSSQEQG------ELQ 579 +++ +L++E L+ ++Q++ +L + +E +A L++ QQ+ QG +L Sbjct: 498 AQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLS 557 Query: 580 GRLAERESQ--EQGLRQRLLDEQFAVLRGAAA---EAAGILQDAVSKLDDPLHLRCTSSP 634 L ++E Q E +Q + A AA EA+ +DA K + L + Sbjct: 558 SSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKL 617 Query: 635 DYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAP 694 + L + Q A +A + + TS+ A A L+R + H A Sbjct: 618 EILQQQLQVANEARDSAQ-------TSVTQAQREKAELSRKVEELQACVETARQEQHEAQ 670 Query: 695 TDPAD-RLIDTCRECGARALELMGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKS 751 A+ L + A E + Q +D Q+ L+ ++ SL T +G L +E K ++ Sbjct: 671 AQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVT--KGSL---EEEKRRA 725 Query: 752 LDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEV----------NE 801 D +E+ + E+ A + ++ + +R + + R G++ + E Sbjct: 726 ADALEEQQRCI--SELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETE 783 Query: 802 RILNSCTDLMKAIRLLVTTSTSLQKEIVE-SGRGAATQQEFYAKNSRWTEGLISASKAVG 860 + + M A + L KE+ R +QQE + + E L++ + Sbjct: 784 VLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECE 843 Query: 861 WGATQLVEAADKVV-------LHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLS 913 +L EA +KV L + + + H A Q V +V+A K + LS Sbjct: 844 KARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLS 903 Query: 914 RLQECSRTVNERAANVVASTKSGQEQIE 941 LQE ++ A + + EQ E Sbjct: 904 TLQEKMAATSKEVARLETLVRKAGEQQE 931 Score = 70.1 bits (170), Expect = 1e-11 Identities = 157/723 (21%), Positives = 282/723 (39%), Gaps = 99/723 (13%) Query: 336 IESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVD------- 388 +++++RE E + +ELE+++ Q + + E E+ +++ +A D Sbjct: 967 LQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAA 1026 Query: 389 ------------NEQ----------LRHELAQLRAAQLEGERSQGLREEAERKASATEAR 426 NEQ L H L + E + +GL ++ Sbjct: 1027 RAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQT 1086 Query: 427 YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQE----EVARVKEQLAFQVEQVKR- 481 +LKE+ ++ HA ++ A + T E EV+++++Q Q EQ Sbjct: 1087 VKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSL 1146 Query: 482 ESELKLE-----EKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEK 536 E L+ E E+ LE L+ +LE KA EL +Q AL+ ++ + +++ S + Sbjct: 1147 ERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAE 1206 Query: 537 DALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGR----LAERE-SQEQG 591 D V + + SL+ E +S ++ +++GE + +AE E SQ+ Sbjct: 1207 DEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLE 1266 Query: 592 LRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDY---LVSRAQEALDAV 648 R RLL + A AAE + L++ V L + + +S + L S+A+ A + Sbjct: 1267 ERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELG 1326 Query: 649 STLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCREC 708 L+ ++ S L T L ++ + HL A++ R Sbjct: 1327 QELKAWQEKFFQKEQALSTLQLEHTSTQALVSELL----PAKHLCQQLQAEQAAAEKRH- 1381 Query: 709 GARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMA 768 LE Q +QA ++A L+R +LG EL P V ++E A + Sbjct: 1382 -REELE-----QSKQAAGGLRAELLRAQ----RELG-ELIPLRQKVAEQERTAQQLRAEK 1430 Query: 769 ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLM--KAIRLLVTTSTSLQK 826 A+ A +++ ++ + + G + + + L D K ++ L + Sbjct: 1431 ASYAEQLSMLKKAHGLLAE-ENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAET 1489 Query: 827 EIVESGRGA-ATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIV 885 + E R A +T +E +++ EG A V + E K+ T + E+L V Sbjct: 1490 RLAEVQREAQSTARELEVMTAKY-EG---AKVKVLEERQRFQEERQKL---TAQVEQLEV 1542 Query: 886 CS-------HEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQE 938 E++ A ASKV+ K L +Q + A + A Q Sbjct: 1543 FQREQTKQVEELSKKLADSDQASKVQQQK----LKAVQAQGGESQQEAQRLQAQLNELQA 1598 Query: 939 QIEDRD-TMDFSGLSLIKLK---------KQEMETQVRVLEL----EKTLEAERMRLGEL 984 Q+ ++ + L + K K QE++ Q+R LE K L AE RLG Sbjct: 1599 QLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHE 1658 Query: 985 RKQ 987 +Q Sbjct: 1659 LQQ 1661 Score = 63.9 bits (154), Expect = 7e-10 Identities = 151/690 (21%), Positives = 278/690 (40%), Gaps = 91/690 (13%) Query: 335 QIESLKREVEMLRSELEK-------IKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALV 387 Q+ +LK E E R EL++ I+ ++ I++ ++++ L L +Q Q+ V Sbjct: 834 QLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEV 893 Query: 388 DNEQLRHELAQLRAAQLEGERSQGLREEAERKASAT-EARYNKLKEKHSELVHVHAELLR 446 ++L +L+ L+ + E RKA E +L ++ + E L Sbjct: 894 RAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLE 953 Query: 447 KNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVK---RESELKLEEKSDQLEKLKRELEA 503 + +Q TQ + + + R EQ+ ++E+++ ES+ + +E+ Q E RE+ Sbjct: 954 EQQ--GRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQE---REVAR 1008 Query: 504 KAGELARAQEALSHTEQSKSELSSRLDTLSAE--------KDALSGAVRQREADLLAAQS 555 E RAQ L+ + +++EL RL E ++AL+ A+ ++E Sbjct: 1009 LTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAK 1068 Query: 556 LVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGIL 615 L R EAA +E + Q +L+ +LA++E ++ A GA +EAAG Sbjct: 1069 L-RGLEAAQIKELEELRQTVKQLKEQLAKKE------------KEHASGSGAQSEAAGRT 1115 Query: 616 QDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRF 675 + KL+ LR S L + Q+ + +LE S A+ + + L Sbjct: 1116 EPTGPKLE---ALRAEVSK--LEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQ 1170 Query: 676 SHLAADTIINGGATSHLAPTDPADRLIDTCRECGARAL-ELMGQLQDQQALRHMQASLVR 734 A + G + S LA T + ++A E Q+ + + SL+ Sbjct: 1171 LEEKAQEL--GHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLIS 1228 Query: 735 TPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVR--RIEDMMNQARHA- 791 + + + L +++ K + +EL +V E + S +E+ +R + E N AR A Sbjct: 1229 SLEEEVSILNRQVLEK--EGESKELKRLVMAE-SEKSQKLEERLRLLQAETASNSARAAE 1285 Query: 792 -SSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTE 850 SS ++ EV L + S +L++E+ A +E + W E Sbjct: 1286 RSSALREEVQ--------SLREEAEKQRVASENLRQELTSQAERA---EELGQELKAWQE 1334 Query: 851 GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSP 910 +A+ QL + + ++ EL+ H A+ AA K Sbjct: 1335 KFFQKEQAL--STLQLEHTSTQALV-----SELLPAKHLCQQLQAEQAAAEK-------R 1380 Query: 911 HLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLEL 970 H L++ + A ++ + + E I ++ K E E + L Sbjct: 1381 HREELEQSKQAAGGLRAELLRAQRELGELIP------------LRQKVAEQERTAQQLRA 1428 Query: 971 EKTLEAERMRLGELRKQHYVLAGASGSPGE 1000 EK AE++ + L+K H +LA + GE Sbjct: 1429 EKASYAEQLSM--LKKAHGLLAEENRGLGE 1456 Score = 52.8 bits (125), Expect = 2e-06 Identities = 67/265 (25%), Positives = 121/265 (45%), Gaps = 47/265 (17%) Query: 327 SVKDDRDLQIESLKREVEMLRSELE-----------KIKLEAQRYIAQ---LKSQVNALE 372 +V+ D + ++ ++RE + ELE K+ E QR+ + L +QV LE Sbjct: 1482 AVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLE 1541 Query: 373 GELEEQRKQKQ---KALVDNEQL-RHELAQLRAAQLEGERSQGLREEAERKASATEARYN 428 EQ KQ + K L D++Q + + +L+A Q +G SQ + + + + +A+ + Sbjct: 1542 VFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLS 1601 Query: 429 KLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLE 488 + KE+ +E + E + + D K QQ+QE ++EQL +EQ+++E+ Sbjct: 1602 Q-KEQAAEHYKLQMEKAKTHYDAKK-----QQNQE----LQEQLR-SLEQLQKEN----- 1645 Query: 489 EKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREA 548 ++L+ E E EL +A EQ+ L++++ +L A+ V + Sbjct: 1646 ------KELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQ-------VAHADQ 1692 Query: 549 DLLAAQSLVRETEAALSREQQRSSQ 573 L T+A SRE Q Q Sbjct: 1693 QLRDLGKFQVATDALKSREPQAKPQ 1717 >gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] Length = 1960 Score = 80.5 bits (197), Expect = 8e-15 Identities = 144/711 (20%), Positives = 298/711 (41%), Gaps = 83/711 (11%) Query: 331 DRDLQIESLKREVEMLRSELEKIKLEAQRYI----------AQLKSQVNA---------- 370 ++ L E+ E+E L+S+L KL+ Q + +L++++ A Sbjct: 859 EKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICH 918 Query: 371 -LEGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNK 429 LE +EE+ ++ Q + ++++ + +L QLE E S R++ + + TEA+ K Sbjct: 919 DLEARVEEEEERCQHLQAEKKKMQQNIQELE-EQLEEEES--ARQKLQLEKVTTEAKLKK 975 Query: 430 LKEKHSELVHVHAELLRKN-------ADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRE 482 L+E+ L + +L ++ A+ LT ++ + +A++K + + + E Sbjct: 976 LEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDL--E 1033 Query: 483 SELKLEEKSDQ-LEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSG 541 L+ EEK Q LEK +R+LE + +L+ + ++ + +EL +L E A Sbjct: 1034 ERLRREEKQRQELEKTRRKLEGDSTDLS---DQIAELQAQIAELKMQLAKKEEELQAALA 1090 Query: 542 AVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQF 601 V + A A +RE E+ +S Q+ +L+ A R E+ ++R L E+ Sbjct: 1091 RVEEEAAQKNMALKKIRELESQISELQE-------DLESERASRNKAEK--QKRDLGEEL 1141 Query: 602 AVLRGA---AAEAAGILQDAVSKLDDPLH-LRCTSSPDYLVSRAQEALDAVSTLEEGHAQ 657 L+ ++ Q+ SK + ++ L+ T + AQ + + + H+Q Sbjct: 1142 EALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQ-----IQEMRQKHSQ 1196 Query: 658 YLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMG 717 + LA+ + A T+ N LA + L+ + + ++ Sbjct: 1197 AVEELAEQLEQTKRVKANLEKAKQTLEN--ERGELA--NEVKVLLQGKGDSEHKRKKVEA 1252 Query: 718 QLQDQQALRHMQASLVRTPL-QGILQLGQEL-KPKSLDVRQEELGAVVDKEMAATSAAIE 775 QLQ+ Q ++ + VRT L + +L EL L + + + + K+ +A + ++ Sbjct: 1253 QLQELQ-VKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQ 1311 Query: 776 DAVRRIEDMMNQARHASSGVKLEVNERILNSCTD-----------LMKAIRLLVTTSTSL 824 D +++ Q S+ +K +E+ NS + L K I L + Sbjct: 1312 DTQELLQEENRQKLSLSTKLKQVEDEK--NSFREQLEEEEEAKHNLEKQIATLHAQVADM 1369 Query: 825 QKEIVESGRGAATQQEFYAKNSRWTEGL-------ISASKAVGWGATQLVEAADKVVLHT 877 +K++ +S T +E K + EGL ++A + T+L + D +++ Sbjct: 1370 KKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDL 1429 Query: 878 GKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQ 937 + + QL+A K + K++ R + +R +A ++ + + Sbjct: 1430 DHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAM 1489 Query: 938 EQIEDRDTMDFS-GLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQ 987 EQ + + ++ + L + + V ELEK+ A ++ E++ Q Sbjct: 1490 EQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQ 1540 Score = 73.6 bits (179), Expect = 9e-13 Identities = 153/764 (20%), Positives = 313/764 (40%), Gaps = 138/764 (18%) Query: 325 NGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEG----------- 373 N + ++++ + LK + E + ++LE+ ++ +L+ LEG Sbjct: 1007 NLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAE 1066 Query: 374 ------ELEEQRKQKQKAL------VDNEQLRHELAQLRAAQLEGERSQGLREEAERKAS 421 EL+ Q +K++ L V+ E + +A + +LE + S+ L+E+ E + + Sbjct: 1067 LQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISE-LQEDLESERA 1125 Query: 422 ATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQL-------AF 474 + + ++ EL + EL TA Q + + ++EV +K+ L Sbjct: 1126 SRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEA 1185 Query: 475 QVEQVKRESELKLEEKSDQ----------LEKLKRELEAKAGELARAQEAL--------- 515 Q+++++++ +EE ++Q LEK K+ LE + GELA + L Sbjct: 1186 QIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEH 1245 Query: 516 ----------------SHTEQSKSELSSRLDTLSAEKDALSGAVRQREA-------DLLA 552 + E+ ++EL+ ++ L E D ++G + Q ++ D A Sbjct: 1246 KRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSA 1305 Query: 553 AQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRL---------LDEQFAV 603 +S +++T+ L Q ++++ L +L + E ++ R++L L++Q A Sbjct: 1306 LESQLQDTQELL----QEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIAT 1361 Query: 604 LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDY--LVSRAQEALDAVSTLEEGHAQYLTS 661 L A+ ++D+V L+ ++ D L R +E + A LE+ + Sbjct: 1362 LHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQE 1421 Query: 662 LAD-----------ASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGA 710 L D A L +F L A+ T + DR RE Sbjct: 1422 LDDLLVDLDHQRQSACNLEKKQKKFDQLLAEE-----KTISAKYAEERDRAEAEAREKET 1476 Query: 711 RALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV---DKEM 767 +AL L L++ +A L R Q ++ + K +++G V +K Sbjct: 1477 KALSLARALEEAM---EQKAELERLNKQFRTEMEDLMSSK------DDVGKSVHELEKSK 1527 Query: 768 AATSAAIEDAVRRIEDMMNQARHASSG-VKLEVNERILNSCTDLMKAIRLLVTTSTSLQK 826 A +E+ ++E++ ++ + ++LEVN + + + + ++ S +K Sbjct: 1528 RALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKA--QFERDLQGRDEQSEEKKK 1585 Query: 827 EIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQL---VEAA----DKVVLHTGK 879 ++V R + E K ++A K + L +++A D+ + K Sbjct: 1586 QLVRQVREMEAELEDERKQRSMA---VAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRK 1642 Query: 880 YE-ELIVCSHEI---AASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKS 935 + ++ C E+ AS +++A +K K S E + E AA A ++ Sbjct: 1643 LQAQMKDCMRELDDTRASREEILAQAKENEKKLK---SMEAEMIQLQEELAAAERAKRQA 1699 Query: 936 GQEQIEDRDTM-DFSGLSLIKLKKQEMETQVRVLELEKTLEAER 978 QE+ E D + + SG + L +++ + R+ +LE+ LE E+ Sbjct: 1700 QQERDELADEIANSSGKGALAL-EEKRRLEARIAQLEEELEEEQ 1742 Score = 71.2 bits (173), Expect = 5e-12 Identities = 153/721 (21%), Positives = 285/721 (39%), Gaps = 107/721 (14%) Query: 335 QIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 394 ++E + ++E E E+ Q +++ + LE +LEE+ +QK ++ Sbjct: 912 ELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEA 971 Query: 395 ELAQLRAAQ--LEGERSQGLREE-------AERKASATEARYN-----KLKEKHSELVHV 440 +L +L Q LE + + +E+ AE + TE KLK KH ++ Sbjct: 972 KLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITD 1031 Query: 441 HAELLRKNADTAKQLTVTQQSQE--------EVARVKEQLA-FQVEQVKRESEL------ 485 E LR+ ++L T++ E ++A ++ Q+A +++ K+E EL Sbjct: 1032 LEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALAR 1091 Query: 486 -------------KLEEKSDQLEKLKRELEAKAGELARAQEAL----SHTEQSKSELSSR 528 K+ E Q+ +L+ +LE++ +A++ E K+EL Sbjct: 1092 VEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDT 1151 Query: 529 LDTLSAEKDALSGAVRQREADLL--AAQSLVRETEAALSREQQRSSQEQGELQGRL---- 582 LD+ +A+++ S R++E ++L + + EA + +Q+ SQ EL +L Sbjct: 1152 LDSTAAQQELRS--KREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTK 1209 Query: 583 ---AERESQEQGL---RQRLLDEQFAVLRGAA------AEAAGILQDAVSKLDDPLHLRC 630 A E +Q L R L +E +L+G + LQ+ K ++ +R Sbjct: 1210 RVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVR- 1268 Query: 631 TSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATS 690 T D + E + L + ++ D SAL + L L + N S Sbjct: 1269 TELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEE--NRQKLS 1326 Query: 691 HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQ---GILQLGQEL 747 + ++ RE E L+ Q A H Q + ++ ++ G L+ +E+ Sbjct: 1327 LSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEV 1386 Query: 748 KPK------SLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARH-ASSGVKLEVN 800 K K L R EE A DK + T ++ + ++D++ H S LE Sbjct: 1387 KRKLQKDLEGLSQRHEEKVAAYDK-LEKTKTRLQ---QELDDLLVDLDHQRQSACNLEKK 1442 Query: 801 ERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVG 860 ++ K +LL T K E R A +E K +S ++A+ Sbjct: 1443 QK---------KFDQLLAEEKTISAKYAEERDRAEAEAREKETK-------ALSLARALE 1486 Query: 861 WGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKV---KANKHSPHLSRLQE 917 Q E + E+L+ ++ S +L + + + + L L++ Sbjct: 1487 EAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELED 1546 Query: 918 CSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAE 977 + + + + ++ + Q E RD S + KK+++ QVR E+E LE E Sbjct: 1547 ELQATEDAKLRLEVNLQAMKAQFE-RDLQGRDEQS--EEKKKQLVRQVR--EMEAELEDE 1601 Query: 978 R 978 R Sbjct: 1602 R 1602 Score = 62.4 bits (150), Expect = 2e-09 Identities = 73/334 (21%), Positives = 141/334 (42%), Gaps = 57/334 (17%) Query: 335 QIESLKREVEMLRSELE-----KIKLE--------------------AQRYIAQLKSQVN 369 Q+E +K ++E L EL+ K++LE ++ QL QV Sbjct: 1533 QVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVR 1592 Query: 370 ALEGELEEQRKQKQKALVDNEQLRHELAQLRA----------------AQLEGERSQGLR 413 +E ELE++RKQ+ A+ ++L +L L A +L+ + +R Sbjct: 1593 EMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMR 1652 Query: 414 EEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLA 473 E + +AS E + KE +L + AE+++ + A +Q+Q+E +++LA Sbjct: 1653 ELDDTRASREEI-LAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQE----RDELA 1707 Query: 474 FQVEQVKRESELKLEEK---SDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLD 530 ++ + L LEEK ++ +L+ ELE + G + L ++++ L+ Sbjct: 1708 DEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLN 1767 Query: 531 TLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQ 590 + A +Q E + ++E E + + + S L+ ++A+ E Q Sbjct: 1768 LERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASIT---ALEAKIAQLEEQ-- 1822 Query: 591 GLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDD 624 L + Q A + E L+D + ++DD Sbjct: 1823 -LDNETKERQAACKQVRRTEKK--LKDVLLQVDD 1853 Score = 55.1 bits (131), Expect = 3e-07 Identities = 60/277 (21%), Positives = 126/277 (45%), Gaps = 25/277 (9%) Query: 331 DRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNE 390 ++ ++E L ++ +L K + + + +L+ ALE ++EE + Q E Sbjct: 1490 EQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQL-------E 1542 Query: 391 QLRHELAQLRAAQLEGE-RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 449 +L EL A+L E Q ++ + ER + R + +EK +LV E+ + Sbjct: 1543 ELEDELQATEDAKLRLEVNLQAMKAQFERD---LQGRDEQSEEKKKQLVRQVREMEAELE 1599 Query: 450 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGEL- 508 D KQ ++ +++++ + L ++ + +E QL KL+ +++ EL Sbjct: 1600 DERKQRSMAVAARKKLEMDLKDLEAHIDSANKNR----DEAIKQLRKLQAQMKDCMRELD 1655 Query: 509 ---ARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVR-----QREADLLAAQSLVRET 560 A +E L+ ++++ +L S + ++ L+ A R Q+E D LA + Sbjct: 1656 DTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSG 1715 Query: 561 EAALSREQQRSSQEQ-GELQGRLAERESQEQGLRQRL 596 + AL+ E++R + + +L+ L E + + + RL Sbjct: 1716 KGALALEEKRRLEARIAQLEEELEEEQGNTELINDRL 1752 Score = 54.7 bits (130), Expect = 5e-07 Identities = 54/247 (21%), Positives = 106/247 (42%), Gaps = 26/247 (10%) Query: 337 ESLKREVEMLRSEL----------------EKIKLEAQRYIAQLKSQVNALEG--ELEEQ 378 E KR+ + R EL EK +LEA+ IAQL+ ++ +G EL Sbjct: 1693 ERAKRQAQQERDELADEIANSSGKGALALEEKRRLEAR--IAQLEEELEEEQGNTELIND 1750 Query: 379 RKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELV 438 R +K +D L + A + E R Q R+ E K E + + + Sbjct: 1751 RLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASIT 1810 Query: 439 HVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLA---FQVEQVKRESEL---KLEEKSD 492 + A++ + + Q + ++V R +++L QV+ +R +E + ++ S Sbjct: 1811 ALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKAST 1870 Query: 493 QLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLA 552 +L++LKR+LE E RA + ++ + + D ++ E +L +R+ + + Sbjct: 1871 RLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDLPFVV 1930 Query: 553 AQSLVRE 559 + + R+ Sbjct: 1931 PRRMARK 1937 Score = 52.8 bits (125), Expect = 2e-06 Identities = 76/348 (21%), Positives = 154/348 (44%), Gaps = 33/348 (9%) Query: 330 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 389 + + + + L E + + ++ + + A+ + +++ +L LEE +QK + N Sbjct: 1440 EKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLN 1499 Query: 390 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 449 +Q R E+ L +++ + +S E E+ A E + ++K + EL + L+ Sbjct: 1500 KQFRTEMEDLMSSKDDVGKSV---HELEKSKRALEQQVEEMKTQLEEL----EDELQATE 1552 Query: 450 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELA 509 D +L V Q+ +K Q ++ +SE K ++ Q+ +++ ELE + + + Sbjct: 1553 DAKLRLEVNLQA------MKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRS 1606 Query: 510 RAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA------A 563 A A E +L + +D+ + +D +R+ +A + + +T A A Sbjct: 1607 MAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILA 1666 Query: 564 LSREQQRS----SQEQGELQGRLAERE---SQEQGLRQRLLDE-QFAVLRGA-AAEAAGI 614 ++E ++ E +LQ LA E Q Q R L DE + +GA A E Sbjct: 1667 QAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRR 1726 Query: 615 LQDAVSKLDDPLHLR--CTSSPDYLVSRAQEALDAVST---LEEGHAQ 657 L+ +++L++ L T + + +A +D ++T LE HAQ Sbjct: 1727 LEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQ 1774 Score = 44.3 bits (103), Expect = 6e-04 Identities = 116/563 (20%), Positives = 212/563 (37%), Gaps = 80/563 (14%) Query: 462 QEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQS 521 QEE KE+ +V RE +L E + ++E L+ +L A E + QE L Q+ Sbjct: 843 QEEEMMAKEEELVKV----REKQLAAENRLTEMETLQSQLMA---EKLQLQEQL----QA 891 Query: 522 KSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGR 581 ++EL + + L A A + + DL A E L E+++ Q EL+ + Sbjct: 892 ETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQ 951 Query: 582 LAERESQEQGL---------RQRLLDEQFAVLRG---AAAEAAGILQDAVSKLDDPL--- 626 L E ES Q L + + L+E+ +L A+ +L+D +++ L Sbjct: 952 LEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEE 1011 Query: 627 -----------------------HLRCTSSPDYLVSRAQEALDAVST-LEEGHAQYLTSL 662 LR + + + L+ ST L + A+ + Sbjct: 1012 EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071 Query: 663 ADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQ 722 A+ +A A + A ++A + RE ++ EL L+ + Sbjct: 1072 AELKMQLAKKEEELQAALARVEEEAAQKNMA--------LKKIRELESQISELQEDLESE 1123 Query: 723 QALRHMQASLVRTPLQGILQLGQELKPKSLD--VRQEELGAVVDKEMAATSAAIEDAVRR 780 +A R+ R + + L EL+ +LD Q+EL + ++E+ +E+ + Sbjct: 1124 RASRNKAEKQKRDLGEELEALKTELE-DTLDSTAAQQELRSKREQEVNILKKTLEEEAKT 1182 Query: 781 IEDMMNQARHASSGVKLEVNERILNS---CTDLMKAIRLLVTTSTSLQKEIVESGRGAAT 837 E + + R S E+ E++ + +L KA + L L E+ +G Sbjct: 1183 HEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGD 1242 Query: 838 QQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQL 897 + K + L G E ADKV +L V + +Q Sbjct: 1243 SEH---KRKKVEAQLQELQVKFNEGERVRTELADKVT-------KLQVELDNVTGLLSQS 1292 Query: 898 VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIED-----RDTMDFSGLS 952 + S S S+LQ+ + E + S + +Q+ED R+ ++ + Sbjct: 1293 DSKSSKLTKDFSALESQLQDTQELLQEENRQKL-SLSTKLKQVEDEKNSFREQLEEEEEA 1351 Query: 953 LIKLKKQEMETQVRVLELEKTLE 975 L+KQ +V +++K +E Sbjct: 1352 KHNLEKQIATLHAQVADMKKKME 1374 Score = 32.3 bits (72), Expect = 2.4 Identities = 66/307 (21%), Positives = 120/307 (39%), Gaps = 32/307 (10%) Query: 695 TDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDV 754 T L + C + AR E +++ +H+QA + Q I +L ++L+ Sbjct: 907 TAKKQELEEICHDLEARVEE------EEERCQHLQAEKKKMQ-QNIQELEEQLE------ 953 Query: 755 RQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLM--- 811 +E + E T A ++ + +Q + KL + +RI T+L Sbjct: 954 EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKL-LEDRIAEFTTNLTEEE 1012 Query: 812 ---KAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVE 868 K++ L ++ ++ E R Q++ K R EG ++ A + Sbjct: 1013 EKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEG--DSTDLSDQIAELQAQ 1070 Query: 869 AADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAAN 928 A+ + K EEL + AQ A K K + +S LQE + ERA+ Sbjct: 1071 IAELKMQLAKKEEELQAALARVEEEAAQKNMALK-KIRELESQISELQEDLES--ERASR 1127 Query: 929 VVASTKS---GQE----QIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRL 981 A + G+E + E DT+D + K+E E + LE+ + ++ Sbjct: 1128 NKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQI 1187 Query: 982 GELRKQH 988 E+R++H Sbjct: 1188 QEMRQKH 1194 >gi|148746195 trichohyalin [Homo sapiens] Length = 1943 Score = 80.5 bits (197), Expect = 8e-15 Identities = 69/270 (25%), Positives = 126/270 (46%), Gaps = 22/270 (8%) Query: 332 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 391 R L+ + L+RE + + ++++ E Q Q + + E E+Q +++Q+ +Q Sbjct: 279 RKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQ 338 Query: 392 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADT 451 LR E + R QL E+ + RE+ R+ E R +L+ + Sbjct: 339 LRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRRE------------------ 380 Query: 452 AKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARA 511 +QL QQ + E +EQ + +Q++RE +L+ E++ + ++L+RE E + E Sbjct: 381 -QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHE 439 Query: 512 QEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLV-RETEAALSREQQR 570 QE ++ K E R D L E++ +R+ L Q RE L E++R Sbjct: 440 QE--RREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERR 497 Query: 571 SSQEQGELQGRLAERESQEQGLRQRLLDEQ 600 QE+ E Q R + E +EQ L+++ +E+ Sbjct: 498 EQQERREQQLRREQEERREQRLKRQEEEER 527 Score = 75.5 bits (184), Expect = 2e-13 Identities = 79/273 (28%), Positives = 126/273 (46%), Gaps = 24/273 (8%) Query: 337 ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELE---EQRKQKQKALVDNEQLR 393 + L+RE E R + + + E +R QL+ + E + EQ+ ++++ L +QLR Sbjct: 337 QQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLR 396 Query: 394 HELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 449 E R QL E R Q LR E + + E R+ + E+ + E + Sbjct: 397 REQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKRE-QEERR 455 Query: 450 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELA 509 D K+ T++ ++E R K+QL E+ +RE LKLEE E+ + + E + +L Sbjct: 456 DWLKREEETERHEQE--RRKQQLKRDQEEERRERWLKLEE-----EERREQQERREQQLR 508 Query: 510 RAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSRE-- 567 R QE + E RL + L +RE + Q L RE E L +E Sbjct: 509 REQEERREQRLKRQEEEERLQQRLRSEQQL-----RREQEERREQLLKREEEKRLEQERR 563 Query: 568 QQRSSQEQGELQGRLAERESQEQGLRQRLLDEQ 600 +QR +EQ E + +L +RE E+ +QRL EQ Sbjct: 564 EQRLKREQEERRDQLLKRE--EERRQQRLKREQ 594 Score = 73.9 bits (180), Expect = 7e-13 Identities = 77/276 (27%), Positives = 130/276 (47%), Gaps = 30/276 (10%) Query: 337 ESLKREVEMLRSELEKI---KLEAQRYIAQLKSQVNAL--------EGELEEQRKQKQKA 385 + L+RE ++ R + E+ K E +R +LK + E E EQ ++KQ+ Sbjct: 417 QQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQL 476 Query: 386 LVDNEQLRHELAQLRAAQLEGE--RSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 443 D E+ R E R +LE E R Q R E + + E R +LK + E E Sbjct: 477 KRDQEEERRE----RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEE------E 526 Query: 444 LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEA 503 L++ + +QL Q+ + E +E+ ++EQ +RE LK E++ + + LKRE E Sbjct: 527 RLQQRLRSEQQLRREQEERREQLLKREEEK-RLEQERREQRLKREQEERRDQLLKREEER 585 Query: 504 KAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAA 563 + L R QE + E+ RL+ +++ +++ E + Q L++ E Sbjct: 586 RQQRLKREQEERLEQRLKREEVE-RLE----QEERREQRLKREEPEEERRQQLLKSEEQE 640 Query: 564 LSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDE 599 R+QQ ++Q + RL +RE +E+ L QRL E Sbjct: 641 ERRQQQLRREQQERREQRL-KREEEEERLEQRLKRE 675 Score = 69.7 bits (169), Expect = 1e-11 Identities = 70/269 (26%), Positives = 131/269 (48%), Gaps = 21/269 (7%) Query: 337 ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQL-RHE 395 + L+RE ++ R + + + E +R+ + K + E L+ ++++++ L E+ RHE Sbjct: 411 QQLRREQQLRREQQLRREQEEERH--EQKHEQERREQRLKREQEERRDWLKREEETERHE 468 Query: 396 LA----QLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADT 451 QL+ Q E R + L+ E E + E R +L+ + E E K + Sbjct: 469 QERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEE----RREQRLKRQEE 524 Query: 452 AKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARA 511 ++L +S++++ R +E+ Q+ +KRE E +LE++ + ++LKRE E + +L + Sbjct: 525 EERLQQRLRSEQQLRREQEERREQL--LKREEEKRLEQERRE-QRLKREQEERRDQLLKR 581 Query: 512 QEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRS 571 +E ++ K E RL+ ++ V + E + Q L RE R+Q Sbjct: 582 EEE-RRQQRLKREQEERLEQRLKREE-----VERLEQEERREQRLKREEPEEERRQQLLK 635 Query: 572 SQEQGELQGRLAERESQEQGLRQRLLDEQ 600 S+EQ E + + RE QE+ QRL E+ Sbjct: 636 SEEQEERRQQQLRREQQER-REQRLKREE 663 Score = 67.0 bits (162), Expect = 9e-11 Identities = 70/275 (25%), Positives = 127/275 (46%), Gaps = 26/275 (9%) Query: 329 KDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVD 388 ++ ++ + + L+RE E R + K + E +R +L+S+ L E EE+R+Q K + Sbjct: 497 REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSE-QQLRREQEERREQLLKREEE 555 Query: 389 NEQLRHELAQLRAAQLEGERSQGLREEAER-----KASATEARYNKLKEKHSELVHVHA- 442 + Q + E R Q L+ E ER K E +LK + E + Sbjct: 556 KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER 615 Query: 443 --ELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLE-KLKR 499 + L++ ++ +S+E+ R ++QL + +Q +RE LK EE+ ++LE +LKR Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERRQQQLRRE-QQERREQRLKREEEEERLEQRLKR 674 Query: 500 ELEAKAGELARAQEALSHTEQSKSELSSRLD----TLSAEKDALSGAVRQREADLLAAQS 555 E E + E A+E EQ++ + SR+ L +E DA V R Sbjct: 675 EHEEERREQELAEE---EQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRK------ 725 Query: 556 LVRETEAALSREQQRSSQEQGELQGRLAERESQEQ 590 +E + ++++ + + ELQ + ER ++Q Sbjct: 726 --QEGQRRRQEQEEKRRRRESELQWQEEERAHRQQ 758 Score = 62.0 bits (149), Expect = 3e-09 Identities = 73/276 (26%), Positives = 126/276 (45%), Gaps = 28/276 (10%) Query: 337 ESLKREVEMLRS----ELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ- 391 E + E E L+S E E+ E Q +L E ++QR+++Q + E+ Sbjct: 184 EERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEE 243 Query: 392 ---------LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHA 442 LR E +L+ + + +R EE RK E R + +E+ + Sbjct: 244 KEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQ------ 297 Query: 443 ELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELE 502 + LR+ ++ ++ Q+E R +++ Q E+ +RE +L+ E++ + ++L+RE E Sbjct: 298 QRLRREQQLRRKQEEERREQQEERREQQERREQQEE-RREQQLRREQEERREQQLRREQE 356 Query: 503 AKAGE--LARAQEALSHTEQSKSELSSRLDT-LSAEKDALSGAVRQREADLLAAQSLVRE 559 + E L R QE +Q + E R + L E+ +RE L Q L RE Sbjct: 357 EERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 416 Query: 560 TEAALSREQQ-RSSQEQGELQGRLAERESQEQGLRQ 594 + L REQQ R QE+ E + E+E +EQ L++ Sbjct: 417 QQ--LRREQQLRREQEE-ERHEQKHEQERREQRLKR 449 Score = 61.6 bits (148), Expect = 4e-09 Identities = 74/280 (26%), Positives = 127/280 (45%), Gaps = 29/280 (10%) Query: 337 ESLKREVE-MLRSELEKIKLEAQ----RYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 391 E L++E E +LR E EK + + + R +L+ + L GE E+R+++++ ++ Sbjct: 934 EQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQER----EKK 989 Query: 392 LRHELAQLRAAQLEGERSQGLREEAE-RKASATEARYNKLKEKHSELVHVHAELLRKNAD 450 R E +L+ E Q LREE E R+ E +Y K E E +LLR+ + Sbjct: 990 YREE------EELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE----EEQLLREERE 1039 Query: 451 TAKQLTVTQQ--SQEEVARVKEQLAFQVEQVKRESEL-----KLEEKSDQLEKLKRELEA 503 + +Q +EE+ + +EQL + + +R EL K EE + E+L RE Sbjct: 1040 KRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPE 1099 Query: 504 KAGELARAQEALSHTE-QSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRET-E 561 K R ++ E Q + E R + + L R+ E + L+RE E Sbjct: 1100 KRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPE 1159 Query: 562 AALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQF 601 +E +R +E+ ELQ + +EQ R++ + Q+ Sbjct: 1160 KRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQY 1199 Score = 59.3 bits (142), Expect = 2e-08 Identities = 62/288 (21%), Positives = 124/288 (43%), Gaps = 30/288 (10%) Query: 340 KREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQL 399 + + L+ E + ++ + +R +Q + + +LEE+RK+++ L L+ +L + Sbjct: 843 RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKE 902 Query: 400 RAAQLEGERSQGLREEAERKASATEARY---NKLKEKHSELVHVHAELLR---KNADTAK 453 + E E E +R+ E +Y +L+++ +L+ E R + K Sbjct: 903 QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRK 962 Query: 454 QLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELE---------AK 504 + Q+ ++ + E+ Q + K E +L+++ +QL + +RE K Sbjct: 963 DKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRK 1022 Query: 505 AGELARAQEALSHTEQSKSELSSR------LDTLSAEKDALSGAVRQR------EADLLA 552 EL + +E L E+ K L R + L E++ L G R+ E Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRK 1082 Query: 553 AQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQ 600 + L +E E L E ++ +++ E Q R E QE+ ++LL E+ Sbjct: 1083 EEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEE---EQLLREE 1127 Score = 58.5 bits (140), Expect = 3e-08 Identities = 59/234 (25%), Positives = 103/234 (44%), Gaps = 34/234 (14%) Query: 372 EGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATE-ARYNKL 430 E +L+E+ Q+Q+ L + E+ +L ER + RE E + R +L Sbjct: 257 EEKLQEEEPQRQRELQEEEEQLRKL----------ERQELRRERQEEEQQQQRLRREQQL 306 Query: 431 KEKHSELVHVHAELLRKNADTAKQLTVTQQSQ---EEVARVKEQLAFQVEQVKRESELKL 487 + K E E R+ + +Q ++ Q E+ R ++QL + E+ +RE +L+ Sbjct: 307 RRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRR 366 Query: 488 EEKSDQLE-KLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQR 546 E++ ++ E +L+RE + + + R ++ L +Q + E R R Sbjct: 367 EQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR-----------------R 409 Query: 547 EADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQ 600 E L Q L RE + L REQ+ EQ Q R +R +EQ R+ L + Sbjct: 410 EQQLRREQQLRREQQ--LRREQEEERHEQKHEQERREQRLKREQEERRDWLKRE 461 Score = 57.4 bits (137), Expect = 7e-08 Identities = 73/304 (24%), Positives = 133/304 (43%), Gaps = 47/304 (15%) Query: 328 VKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGEL---EEQRKQKQK 384 ++ ++ L+ E +R ++L+ E EK +LE +R +LK + +L EE+R+Q++ Sbjct: 532 LRSEQQLRREQEERREQLLKREEEK-RLEQERREQRLKREQEERRDQLLKREEERRQQRL 590 Query: 385 ALVDNEQLRHELAQLRAAQLEGE----------------RSQGLREEAER-------KAS 421 E+L L + +LE E R Q L+ E + + Sbjct: 591 KREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRRE 650 Query: 422 ATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEV-ARVKE-----QLAFQ 475 E R +LK + E + L R++ + ++ + ++ QE+ R+K Q + Sbjct: 651 QQERREQRLKREEEE-ERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLE 709 Query: 476 VEQVKRESELKLEEKSDQLEKLKRELEAK----AGELARAQEALSHTEQSKSELSSRLDT 531 E R+S++ + + ++ ++E E K EL +E +H +Q + E R T Sbjct: 710 SEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEE-QRRDFT 768 Query: 532 LSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQG 591 + + S RQR L+A+ +RE R ++R +E Q L E E +EQ Sbjct: 769 WQWQAEEKSERGRQR----LSARPPLREQRERQLRAEERQQRE----QRFLPEEEEKEQR 820 Query: 592 LRQR 595 RQR Sbjct: 821 RRQR 824 Score = 54.7 bits (130), Expect = 5e-07 Identities = 67/287 (23%), Positives = 122/287 (42%), Gaps = 29/287 (10%) Query: 329 KDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVD 388 + DRD + RE E LR E E+ +L Q + + LE + +++Q++K + D Sbjct: 1550 RQDRDRKF----REEEQLRQEREEQQLSRQERDRKFR-----LEEQKVRRQEQERKFMED 1600 Query: 389 NEQLRHELAQLRAAQ-------------LEGERSQGLREEAERKASATEARYNKLKEKHS 435 +QLR + Q + Q E E Q R+E +RK E + + +E+ Sbjct: 1601 EQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRR-QEREQ 1659 Query: 436 ELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLE 495 +L H R+ ++ Q ++E R + Q+ + +RE + EE+ + + Sbjct: 1660 QLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQ 1719 Query: 496 KLKREL-EAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQ 554 +L+R+ E + QE L E+ + L E+ L R R+ Sbjct: 1720 ELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQL 1779 Query: 555 SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQF 601 RE + S+E R +E+ +L+ +E +EQ LR + D ++ Sbjct: 1780 RQEREEQQLRSQESDRKFREEEQLR-----QEREEQQLRPQQRDGKY 1821 Score = 54.3 bits (129), Expect = 6e-07 Identities = 60/278 (21%), Positives = 134/278 (48%), Gaps = 14/278 (5%) Query: 329 KDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVD 388 + +RD + +++V R E E+ LE ++ + Q + + E +L ++R+++Q + Sbjct: 1425 RQERDRKFREEEQQVR--RQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQE 1482 Query: 389 NEQ-LRHELAQLRAAQLEGE-RSQGLR-EEAERKASATEARYNKLKEKHSELVHVHAELL 445 ++ E QLR + + + R Q LR +E ERK E + ++ +++ + + +L Sbjct: 1483 RDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHR-QQRQRKFLQEEQQLR 1541 Query: 446 RKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKA 505 R+ ++ ++ +EE +E+ Q+ + +R+ + +LEE+ + ++ +R+ Sbjct: 1542 RQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDE 1601 Query: 506 GELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVR--ETEAA 563 +L R QE Q + + L E++ ++R+ L + +R E E Sbjct: 1602 QQL-RRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQ 1660 Query: 564 LSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQF 601 L ++ R +E+ +L +E +EQ LR++ D +F Sbjct: 1661 LRHDRDRKFREEEQLL-----QEGEEQQLRRQERDRKF 1693 Score = 53.5 bits (127), Expect = 1e-06 Identities = 60/286 (20%), Positives = 124/286 (43%), Gaps = 24/286 (8%) Query: 328 VKDDRDLQIESLKREVE------MLRSELEKIKLEAQRYIAQLKSQV-------NALEGE 374 +K + + + + LKRE E + R E+E+++ E +R +LK + L+ E Sbjct: 579 LKREEERRQQRLKREQEERLEQRLKREEVERLEQEERRE-QRLKREEPEEERRQQLLKSE 637 Query: 375 LEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKH 434 +E+R+Q+Q E+ L + + +R + EE R+ E + +E+ Sbjct: 638 EQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERI 697 Query: 435 SELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQL 494 + L AD + ++ ++E R ++ + E+ +R E +L+ + ++ Sbjct: 698 KSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQ----EQEEKRRRRESELQWQEEER 753 Query: 495 EKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQ 554 +++ E + + +A +E+ + LS+R + L RQ+ Q Sbjct: 754 AHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQR-----EQ 808 Query: 555 SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQ 600 + E E R +QR +E+ ELQ E + Q + Q+L +E+ Sbjct: 809 RFLPEEEEKEQRRRQRREREK-ELQFLEEEEQLQRRERAQQLQEEE 853 Score = 53.5 bits (127), Expect = 1e-06 Identities = 66/264 (25%), Positives = 118/264 (44%), Gaps = 25/264 (9%) Query: 346 LRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQL----RA 401 LR + E+ +L A+ Q + Q E E +EQR+++++ Q E QL RA Sbjct: 790 LREQRER-QLRAEE--RQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERA 846 Query: 402 AQLEGERSQGLREEAERKASATEARYNK----LKEKHSELVHVHAELLRKNADTAKQLTV 457 QL+ E GL+E+ ER+ S + R K L+E+ H K+ + Sbjct: 847 QQLQ-EEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQL 905 Query: 458 TQQSQEEVARVKEQLAFQVEQVKR-ESELKLEEKSDQLEKLKRELEAKAGELARAQEALS 516 Q+ +EE+ R + + + EQ ++ E +L+++ +QL + +RE R QE Sbjct: 906 LQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKR-------RRQERER 958 Query: 517 HTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQG 576 + K L E + ++RE + L +E E L E+++ +++ Sbjct: 959 QYRKDKKLQQKEEQLLGEEPE--KRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEW 1016 Query: 577 ELQGRLAERESQEQGLRQRLLDEQ 600 E Q R + QE+ ++LL E+ Sbjct: 1017 ERQYRKKDELQQEE---EQLLREE 1037 Score = 53.1 bits (126), Expect = 1e-06 Identities = 63/268 (23%), Positives = 114/268 (42%), Gaps = 34/268 (12%) Query: 342 EVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA 401 E ++ R E ++ E ++ + + + + L+ E + +R++ ++ + EQLR E Q + Sbjct: 1681 EQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQL 1740 Query: 402 AQLEGERS----QGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTV 457 + E R + LR E E + + R K +E+ + LR K Sbjct: 1741 RRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREE 1800 Query: 458 TQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSH 517 Q QE R ++QL Q +R+ + + EE+ QLE+ ++ L + RA+E + Sbjct: 1801 EQLRQE---REEQQLRPQ----QRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFAT 1853 Query: 518 TEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGE 577 E+S+ E ++E Q +E E L E R Q++ + Sbjct: 1854 QEKSRRE--------------------EQELWQEEEQKRRQERERKLREEHIRRQQKEEQ 1893 Query: 578 LQGRLAERESQEQGLRQRLLD---EQFA 602 ++ E +SQE RLL+ QFA Sbjct: 1894 RHRQVGEIKSQEGKGHGRLLEPGTHQFA 1921 Score = 52.8 bits (125), Expect = 2e-06 Identities = 79/299 (26%), Positives = 131/299 (43%), Gaps = 45/299 (15%) Query: 329 KDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQ---LKSQVNALEGELEEQRK----- 380 +++ +LQ E E ++LR E EK + E +R + L+ Q E+QR Sbjct: 1171 REEEELQQE----EEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQ 1226 Query: 381 ---QKQKALVDN---------EQLRH-ELAQLRAAQLEGERSQGLREEAERKASATEARY 427 +K+ A+ DN EQ R E +QLR Q + + L E+ ER R+ Sbjct: 1227 WEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRW 1286 Query: 428 NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 487 + E +L R+ AK+ ++SQEE ++E+ + ++ ++E++ K Sbjct: 1287 QQRDRHFPE----EEQLEREEQKEAKRRD--RKSQEEKQLLREER--EEKRRRQETDRKF 1338 Query: 488 EEKSDQL-EKLKRELEAKAGELARAQEALSHTEQSKS--ELSSRLDTLSAEKDALSGA-- 542 E+ L E+ ++ L + + +E L H EQ + E RL E+ L Sbjct: 1339 REEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ 1398 Query: 543 --VRQREADLLAAQSL-VRETEAALSREQQRSSQEQGELQGRLAERE----SQEQGLRQ 594 ++RE L + RE E LSR+++ + E Q R ERE +EQ LRQ Sbjct: 1399 LRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQ 1457 Score = 52.0 bits (123), Expect = 3e-06 Identities = 77/282 (27%), Positives = 122/282 (43%), Gaps = 39/282 (13%) Query: 327 SVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKAL 386 S K +R Q + +R+ E+ R E + E +R A E +L+ + + + Sbjct: 155 SEKQERLEQRDRQRRDEELWRQRQEWQEREERR----------AEEEQLQSCKGHETEEF 204 Query: 387 VDNEQLRH-ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 445 D EQLR EL +LR E E+ Q RE +R E + + +E +L Sbjct: 205 PDEEQLRRRELLELRRKGRE-EKQQQRRERQDRVFQEEEEKEWRKRET----------VL 253 Query: 446 RKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKA 505 RK + ++ Q Q E+ +EQL ++E+ + E + EE+ Q + +++L K Sbjct: 254 RKEEEKLQE--EEPQRQRELQEEEEQLR-KLERQELRRERQEEEQQQQRLRREQQLRRKQ 310 Query: 506 GELARAQEALSHTEQSKSELSS--RLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAA 563 E R Q+ +Q + E R L E++ +RE L Q R E Sbjct: 311 EEERREQQEERREQQERREQQEERREQQLRREQE------ERREQQLRREQEEERR-EQQ 363 Query: 564 LSREQQRSSQEQGELQGRLAERESQ---EQGLR--QRLLDEQ 600 L REQ+ +EQ + + RE Q EQ LR Q+L EQ Sbjct: 364 LRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ 405 Score = 52.0 bits (123), Expect = 3e-06 Identities = 70/278 (25%), Positives = 119/278 (42%), Gaps = 25/278 (8%) Query: 331 DRDLQIESLKR------EVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQ--RKQK 382 +R+ Q E+ +R E ++LR E E+ K Q + + + L+ E EEQ R+Q+ Sbjct: 1300 EREEQKEAKRRDRKSQEEKQLLREEREE-KRRRQETDRKFREEEQLLQ-EREEQPLRRQE 1357 Query: 383 QKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHA 442 + E+LRH Q + + E + R+E ERK LKE+ Sbjct: 1358 RDRKFREEELRH---QEQGRKFLEEEQRLRRQERERKF---------LKEEQQLRCQERE 1405 Query: 443 ELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELE 502 + LR++ D + Q S++E R + QV + +RE + EE+ + E+ ++ E Sbjct: 1406 QQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFRE 1465 Query: 503 AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 562 + R ++ L E+ + L E+D R++E + E E Sbjct: 1466 EEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDR---KFREQELRSQEPERKFLEEEQ 1522 Query: 563 ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQ 600 L R+Q++ Q E Q R ER Q + R R E+ Sbjct: 1523 QLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE 1560 Score = 50.1 bits (118), Expect = 1e-05 Identities = 67/284 (23%), Positives = 129/284 (45%), Gaps = 33/284 (11%) Query: 341 REVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLR 400 RE E L+ E E++ L +R + + E E Q++++Q + E+ R + + + Sbjct: 1051 REEEELQQEEEQL-LGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQ 1109 Query: 401 A---AQLEGERSQGLREEAE-RKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLT 456 +L+ E Q LREE E R+ E +Y + +E E +LLR+ + ++ Sbjct: 1110 CREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQE----EEQLLREEPEKRRRQE 1165 Query: 457 VTQQ--SQEEVARVKEQLAFQVEQVKR---------ESELKLEEK------SDQLEKLKR 499 + +Q +EE+ + +EQL + ++ +R E EL+ +++ DQ LK Sbjct: 1166 LERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKW 1225 Query: 500 ELEAKAGELARAQEAL---SHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSL 556 + E + R + EQ + S+L +++D Q+E D + Sbjct: 1226 QWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRR 1285 Query: 557 VRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQ 600 ++ + E+Q +EQ E + R +R+SQE+ +Q L +E+ Sbjct: 1286 WQQRDRHFPEEEQLEREEQKEAKRR--DRKSQEE--KQLLREER 1325 Score = 48.9 bits (115), Expect = 2e-05 Identities = 57/238 (23%), Positives = 103/238 (43%), Gaps = 20/238 (8%) Query: 367 QVNALEGELEEQRKQKQKALVDN----EQLRHELAQLRAAQLEGERSQGLREEAERKASA 422 Q L+ E + K+ L D +Q R E + + G+R + R+E ER+ + Sbjct: 91 QATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAE 150 Query: 423 TEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQL----AFQVEQ 478 E + EK L + R++ + +Q Q+ +E A +EQL + E+ Sbjct: 151 GEEQ----SEKQERL--EQRDRQRRDEELWRQRQEWQEREERRAE-EEQLQSCKGHETEE 203 Query: 479 VKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDA 538 E +L+ E L +L+R+ + + R ++ E+ + E R L E++ Sbjct: 204 FPDEEQLRRRE----LLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEK 259 Query: 539 LSGAVRQREADLLAAQSLVRETE-AALSREQQRSSQEQGELQGRLAERESQEQGLRQR 595 L QR+ +L + +R+ E L RE+Q Q+Q L+ R QE+ R++ Sbjct: 260 LQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQ 317 >gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] Length = 1498 Score = 80.5 bits (197), Expect = 8e-15 Identities = 121/560 (21%), Positives = 227/560 (40%), Gaps = 82/560 (14%) Query: 332 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKS---QVNALEGELEEQRKQKQKALVD 388 +D + L++++ L+S+L++++LE ++LK+ ++++L+ + ++Q A Sbjct: 529 KDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEA 588 Query: 389 NEQLRHELAQLRAAQLE--GERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLR 446 +L+ E+A ++ Q+ G E TE ++ +KEK + A+L Sbjct: 589 RVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKG----RIAAQLQG 644 Query: 447 KNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--------------------LK 486 AD Q Q QE V+E L ++E+ + E E L Sbjct: 645 IEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLT 704 Query: 487 LEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQR 546 L ++ QLE L++E +L QEAL EQS L + D L A L G R Sbjct: 705 LLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASR 764 Query: 547 EADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRG 606 E + Q+ EAAL + +S +E+ + R E ++E L E+ A+ G Sbjct: 765 EDTICLLQNEKIILEAAL--QAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSG 822 Query: 607 AA---AEAAGILQDAVSKLDDPL---------HLRCTSSPDYLVSRAQ--------EALD 646 + L+ + K+ + + R +S D L+S + E + Sbjct: 823 QVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKE 882 Query: 647 AVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 706 L + H + T+ A+ S L + + AD + G S D + + + + Sbjct: 883 LRQELMQVHGEKRTAEAELSRLHREVAQVRQHMAD--LEGHLQSAQKERDEMETHLQSLQ 940 Query: 707 ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKE 766 +++ + +AL+ L + + I + Q+++ D+ + KE Sbjct: 941 ---FDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQ------KE 991 Query: 767 MAATSAAIEDAV----RRIEDMMN------------QARHASSGVKLEVNERILNSCTDL 810 M A E+AV RR+++ + +A+ SS L ++ERI L Sbjct: 992 MKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERI----QAL 1047 Query: 811 MKAIRLLVTTSTSLQKEIVE 830 ++ + + T L+KE+ E Sbjct: 1048 EAELQAVSHSKTLLEKELQE 1067 Score = 73.9 bits (180), Expect = 7e-13 Identities = 111/468 (23%), Positives = 206/468 (44%), Gaps = 72/468 (15%) Query: 337 ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRK-----------QKQKA 385 E+LK+++E L+ E K E ++ + +L S + + + E++ + K + Q+A Sbjct: 954 EALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEA 1013 Query: 386 LVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 445 L E EL QLRA + S L E + A EA + HS+ + + EL Sbjct: 1014 LAAKEAADAELGQLRAQGGSSDSSLALHERIQ----ALEAELQAVS--HSKTL-LEKELQ 1066 Query: 446 RKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKA 505 A T+++L ++S+E+V ++++L Q R K++ + +KL ELE + Sbjct: 1067 EVIALTSQEL---EESREKVLELEDEL-----QESRGFRKKIKRLEESNKKLALELEHEK 1118 Query: 506 GELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALS 565 G+L L + + E +S L+T A+ +READL+ L + +A L Sbjct: 1119 GKLT----GLGQSNAALREHNSILET----------ALAKREADLV---QLNLQVQAVLQ 1161 Query: 566 REQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDP 625 R+++ Q + +Q A E +++ + L EQ A + A + A +L + Sbjct: 1162 RKEEEDRQMKHLVQALQASLEKEKEKVNS--LKEQVAAAKVEAGHNRRHFKAASLELSEV 1219 Query: 626 LHLRCTSSPDYLVSRAQEALDAVSTLEEGH----AQYLTSLADASALVAALTR--FSHLA 679 + + ++LV + Q D + E H AQ+ LA+A A + L + L+ Sbjct: 1220 --KKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLS 1277 Query: 680 ADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQG 739 + N + D +R I ++L+ L +QQ R L+G Sbjct: 1278 KQPVGNQEMENLKWEVDQKEREI--------QSLKQQLDLTEQQG---------RKELEG 1320 Query: 740 ILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQ 787 + QL Q +K L++ QE+L ++ K+ A + + ++ ++ Q Sbjct: 1321 LQQLLQNVK-SELEMAQEDL-SMTQKDKFMLQAKVSELKNNMKTLLQQ 1366 Score = 60.5 bits (145), Expect = 8e-09 Identities = 68/280 (24%), Positives = 130/280 (46%), Gaps = 27/280 (9%) Query: 333 DLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQR--KQKQKALVDNE 390 + +++++ +L EL+++ + + + + +V LE EL+E R ++K K L ++ Sbjct: 1048 EAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESN 1107 Query: 391 -----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 445 +L HE +L G+ + LRE +A R L + + + V A L Sbjct: 1108 KKLALELEHEKGKLTGL---GQSNAALREHNSILETALAKREADLVQLN---LQVQAVLQ 1161 Query: 446 RKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKA 505 RK + + + Q Q + + KE++ EQV + K+E + +R +A + Sbjct: 1162 RKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQV---AAAKVEAGHN-----RRHFKAAS 1213 Query: 506 GELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA----QSLVRETE 561 EL+ ++ L E +L + D L + S + Q +A+L A Q L ++ + Sbjct: 1214 LELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLD 1273 Query: 562 AALSREQQRSSQEQGELQGRLAERESQEQGLRQRL-LDEQ 600 LS+ Q +QE L+ + ++E + Q L+Q+L L EQ Sbjct: 1274 EQLSK-QPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQ 1312 Score = 58.9 bits (141), Expect = 2e-08 Identities = 56/234 (23%), Positives = 109/234 (46%), Gaps = 16/234 (6%) Query: 329 KDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVD 388 K++ D Q++ L V+ L++ LEK K + + LK QV A + E R+ + A ++ Sbjct: 1163 KEEEDRQMKHL---VQALQASLEKEKEK----VNSLKEQVAAAKVEAGHNRRHFKAASLE 1215 Query: 389 NEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKN 448 +++ EL Q + Q L+ EA+ ++ + +EL A+L Sbjct: 1216 LSEVKKEL------QAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQ 1269 Query: 449 ADTAKQLTVTQQSQEEVARVK---EQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKA 505 +QL+ +E+ +K +Q +++ +K++ +L ++ +LE L++ L+ Sbjct: 1270 KQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVK 1329 Query: 506 GELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRE 559 EL AQE LS T++ K L +++ L L +Q + DL + R+ Sbjct: 1330 SELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTRK 1383 Score = 57.0 bits (136), Expect = 9e-08 Identities = 105/474 (22%), Positives = 190/474 (40%), Gaps = 51/474 (10%) Query: 325 NGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQK 384 NG V+ RD S+ LE E Q + Q+ + LEG+LE + + Sbjct: 380 NGEVRSRRDSICSSVS---------LESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQ 430 Query: 385 ALVDNEQLRHELAQLRA-AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 443 AL + +L+ +LA L Q + E S ++ + +S + + + + Sbjct: 431 ALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNM 490 Query: 444 LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEA 503 L KNA A Q ++E+ R L +VE ++R + K + + L++++ A Sbjct: 491 LEAKNASLASSNNDLQVAEEQYQR----LMAKVEDMQR----SMLSKDNTVHDLRQQMTA 542 Query: 504 KAGELARAQ----EALSHTEQSKSELSSRLDTLS--AEKDALSGAVRQREADLLAAQSLV 557 +L + Q S + S++E+SS ++ AL+ R R +A + Sbjct: 543 LQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVG 602 Query: 558 RETEAA----LSREQQRSSQEQGELQGRLAERE----SQEQGLRQRLLDEQFAVLRGAAA 609 + T+A L E SQ+ E Q R + + +Q QG+ +LD++ A ++ Sbjct: 603 QMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQ---- 658 Query: 610 EAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALV 669 +Q+A + +++ L R R Q D+ ++LE+ Q +L + Sbjct: 659 -----IQEAKTMVEEDLQRRLEEFEGER-ERLQRMADSAASLEQQLEQVKLTLLQRDQQL 712 Query: 670 AALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQL---QDQQALR 726 AL + HL + + + D L E AR EL G+ +D L Sbjct: 713 EALQQ-EHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLL 771 Query: 727 HMQASLVRTPLQGILQLGQELK--PKSLDVRQEELGAVVDK---EMAATSAAIE 775 + ++ LQ +EL + L+ EE ++K E+A S +E Sbjct: 772 QNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVE 825 >gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo sapiens] Length = 1941 Score = 79.7 bits (195), Expect = 1e-14 Identities = 168/778 (21%), Positives = 321/778 (41%), Gaps = 132/778 (16%) Query: 329 KDDRDLQIESLKREVEMLRSELEK---IKLEAQRYIAQLKSQVNALEGELEEQRKQKQKA 385 K D +++ + E+ L+S++E + ++ Q+ I +L++++ LE E+E +R + KA Sbjct: 1079 KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKA 1138 Query: 386 LVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVH---- 441 L EL ++ E + + E +K EA + K++ E H Sbjct: 1139 EKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR---EAEFQKMRRDLEEATLQHEATA 1195 Query: 442 AELLRKNADTAKQL--------TVTQQSQEEVARVK---EQLAFQVEQVKRE-------- 482 A L +K+AD+ +L V Q+ ++E + +K + LA VE V + Sbjct: 1196 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMC 1255 Query: 483 -------SELKLEEKSDQ-----LEKLKRELEAKAGELARA---QEAL-SHTEQSKSELS 526 SELK +E+ Q L + L+ ++GE +R +EAL S + K + Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFT 1315 Query: 527 SRLDTLSAE-------KDALSGAVR--QREADLLAAQ-SLVRETEAALSRE--------- 567 +++ L + K+AL+ A++ + + DLL Q +E++A L R Sbjct: 1316 QQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVA 1375 Query: 568 QQRSSQEQGELQGRLAERESQEQGLRQRL--LDEQFAVLRGAAAEAAGILQDAVSKLDD- 624 Q R+ E +Q R E E ++ L QRL +E + A Q ++++D Sbjct: 1376 QWRTKYETDAIQ-RTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDL 1434 Query: 625 PLHLRCTSSPDYLVSRAQEALDAV-----STLEEGHAQYLTSLADASALVAALTRFSHLA 679 L + T++ + + Q D + EE HA+ S +A +L L + + Sbjct: 1435 MLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAY 1494 Query: 680 ADTI--INGGATSHLAPTDPADRLIDTCRECGARA--------------LELMGQLQDQQ 723 +++ + + L + E G R EL L++ + Sbjct: 1495 EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAE 1554 Query: 724 A-LRHMQASLVRTPL---QGILQLGQELKPKSLDVRQ---------EELGAVVDKEMAAT 770 A L H + ++R L Q ++ +++ K ++ Q E + + +D E+ + Sbjct: 1555 ASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSR 1614 Query: 771 SAAI------EDAVRRIEDMMNQA-RHASSGVKLEVNER------------ILNSCTDLM 811 + AI E + +E +N A R A+ ++ N + L S DL Sbjct: 1615 NDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLK 1674 Query: 812 KAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAAD 871 + + ++ + LQ EI E AT ++ + L+ AS+ V QL+ + Sbjct: 1675 EQLAMVERRANLLQAEIEEL---RATLEQTERSRKIAEQELLDASERV-----QLLHTQN 1726 Query: 872 KVVLHTGKYEELIVCSHE-IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVV 930 +++T K E + + Q ++ KA K + + E + + +A++ Sbjct: 1727 TSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1786 Query: 931 ASTKSGQEQIEDRDTM--DFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRK 986 K+ ++ ++D + L+L KKQ + + RV ELE +E+E+ R E K Sbjct: 1787 RMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVK 1844 Score = 68.2 bits (165), Expect = 4e-11 Identities = 147/695 (21%), Positives = 273/695 (39%), Gaps = 83/695 (11%) Query: 328 VKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALV 387 +K+ DLQ++ +++E E + +R +K+++ +LE + K+ + Sbjct: 887 LKEKNDLQLQ--------VQAEAEGLADAEERCDQLIKTKI-----QLEAKIKEVTERAE 933 Query: 388 DNEQLRHELAQLRAAQLEGERSQGLRE---------EAERKASATEARYNKLKEKHSELV 438 D E++ EL + +LE E S+ ++ + E++ ATE + L E+ + L Sbjct: 934 DEEEINAELTA-KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 992 Query: 439 HVHAELLR--KNADTAKQLTVTQQSQEE-----VARVKEQLAFQVEQVKRESELKLEEKS 491 A+L + K A Q T+ EE + + K +L QV+ ++ E + + + Sbjct: 993 ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRM 1052 Query: 492 DQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLL 551 D LE+ KR+LE G+L AQE++ E K +L +L E L + +A + Sbjct: 1053 D-LERAKRKLE---GDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGI 1108 Query: 552 AAQSLVRETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRG 606 Q ++E +A + E +R+S+ + E Q RE +E + +RL Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE--ISERL---------- 1156 Query: 607 AAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA--- 663 E AG A +++ L + +TL + HA + L Sbjct: 1157 ---EEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQI 1213 Query: 664 DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 723 D V I+ A++ + L CR + EL + ++QQ Sbjct: 1214 DNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQ 1273 Query: 724 ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIED 783 L + T +G LQ + LD +E L + + + A + IE+ R++E+ Sbjct: 1274 RLIN-----DLTAQRGRLQTESGEFSRQLD-EKEALVSQLSRGKQAFTQQIEELKRQLEE 1327 Query: 784 MM---NQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQE 840 + N HA + + C L + + LQ+ + ++ A + Sbjct: 1328 EIKAKNALAHALQSSR--------HDCDLLREQYEEEQESKAELQRALSKANTEVAQWRT 1379 Query: 841 FYAKNS-RWTEGLISASKAVG---WGATQLVEAADKVVLHTGKYEELIVCSHE-----IA 891 Y ++ + TE L A K + A + VEA + K ++ + E + Sbjct: 1380 KYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVE 1439 Query: 892 ASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGL 951 + A A K + N Q+C T E A+ + G E + ++ + S Sbjct: 1440 RTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLD 1499 Query: 952 SLIKLKKQEMETQVRVLELEKTLEAERMRLGELRK 986 L LK++ Q + +L + + R+ EL K Sbjct: 1500 QLETLKRENKNLQQEISDLTEQIAEGGKRIHELEK 1534 Score = 60.8 bits (146), Expect = 6e-09 Identities = 137/711 (19%), Positives = 282/711 (39%), Gaps = 90/711 (12%) Query: 334 LQIESLKREV-------EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKAL 386 +Q+E+ +EV E + +EL K + + ++LK ++ LE L + K+K Sbjct: 919 IQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATE 978 Query: 387 VDNEQLRHELAQLRAAQLEGERSQGLREEAERKA----SATEARYNKLKEKHSELVHVHA 442 + L E+A L + + + +EA ++ A E + N L + +L Sbjct: 979 NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVD 1038 Query: 443 EL---------LRKNADTAKQ-----LTVTQQSQEEVARVKEQL-------AFQVEQVKR 481 +L LR + + AK+ L + Q+S ++ K+QL F++ ++ Sbjct: 1039 DLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQS 1098 Query: 482 ESE----------LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDT 531 + E K++E ++E+L+ E+EA+ A+A++ S + E+S RL+ Sbjct: 1099 KIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1158 Query: 532 LSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSS---QEQGELQGRLAERESQ 588 A ++REA+ Q + R+ E A + + ++ ++ + L E+ Sbjct: 1159 AGGATSAQIEMNKKREAEF---QKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDN 1215 Query: 589 EQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL-----VSRAQE 643 Q ++Q+L E+ + A+ + + VSK L C + D L Q+ Sbjct: 1216 LQRVKQKLEKEKSEMKMEIDDLASNV--ETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQ 1273 Query: 644 ALDAVSTLEEGHAQ-----YLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPA 698 L T + G Q + L + ALV+ L+R I L A Sbjct: 1274 RLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEE--LKRQLEEEIKA 1331 Query: 699 DRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDV--RQ 756 + + +L+ + +++ + +A L R + ++ Q D R Sbjct: 1332 KNALAHALQSSRHDCDLLREQYEEE--QESKAELQRALSKANTEVAQWRTKYETDAIQRT 1389 Query: 757 EELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRL 816 EEL K++A A E+ V +A +A + +R+ N DLM + Sbjct: 1390 EEL-EEAKKKLAQRLQAAEEHV--------EAVNAKCASLEKTKQRLQNEVEDLMLDVER 1440 Query: 817 LVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVV-- 874 +L K+ + A ++ + E ++++G ++ A ++ + Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ 1500 Query: 875 LHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTK 934 L T K E + EI+ T Q+ K + L++ + V + + A+ + Sbjct: 1501 LETLKRENKNL-QQEISDLTEQIAEGGK--------RIHELEKIKKQVEQEKCELQAALE 1551 Query: 935 SGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELR 985 + +E + + I+L+ +++++V EK E ++++ +R Sbjct: 1552 EAEASLEHEE----GKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIR 1598 Score = 50.1 bits (118), Expect = 1e-05 Identities = 107/508 (21%), Positives = 213/508 (41%), Gaps = 103/508 (20%) Query: 399 LRAAQLEGERSQGLREEAER---KASATEARYNKLKEKHSELVHVHAELLRKNADTAKQL 455 L++A+ E E + ++EE ++ + + +EA+ +L+EK L+ +L + A+ L Sbjct: 846 LKSAETEKEMAT-MKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904 Query: 456 TVTQQSQEEVARVKEQLAFQVEQVKRESE-------------LKLEEKSDQLEKLKRELE 502 ++ +++ + K QL ++++V +E KLE++ +L+K +LE Sbjct: 905 ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 964 Query: 503 AKAGELARAQEALSHTEQSKSELSSRLD----TLSAEKDALSGAVRQREADLLAAQSLVR 558 ++ + + A + ++ +E + LD L+ EK AL A +Q DL A + V Sbjct: 965 LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVN 1024 Query: 559 E-TEAALSREQQRSSQE--------------------QGEL---QGRLAERESQEQGLRQ 594 T+A + EQQ E +G+L Q + + E+++Q L + Sbjct: 1025 TLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDE 1084 Query: 595 RLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEG 654 +L ++F + + SK++D L L + +E + LEE Sbjct: 1085 KLKKKEFEI------------SNLQSKIEDEQALGI-----QLQKKIKELQARIEELEEE 1127 Query: 655 HAQYLTSLADASALVAALTRFSHLAADTIIN-GGATSHLAPTDPADRLIDTCRECGARAL 713 S A A + L+R ++ + GGATS A ++ RE Sbjct: 1128 IEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS-------AQIEMNKKREA---EF 1177 Query: 714 ELMGQLQDQQALRH--MQASLVRTPLQGILQLGQELK-----PKSLDVRQEELGAVVD-- 764 + M + ++ L+H A+L + + +LG+++ + L+ + E+ +D Sbjct: 1178 QKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL 1237 Query: 765 ----KEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 820 + ++ +E R +ED +++ + K E +R++N DL L T Sbjct: 1238 ASNVETVSKAKGNLEKMCRTLEDQLSELKS-----KEEEQQRLIN---DLTAQRGRLQTE 1289 Query: 821 STSLQKEIVES---------GRGAATQQ 839 S +++ E G+ A TQQ Sbjct: 1290 SGEFSRQLDEKEALVSQLSRGKQAFTQQ 1317 Score = 46.2 bits (108), Expect = 2e-04 Identities = 129/636 (20%), Positives = 247/636 (38%), Gaps = 129/636 (20%) Query: 371 LEGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNK- 429 L G LEE R K L+ Q R + A++E +R ER+ + +YN Sbjct: 775 LLGLLEEMRDDKLAQLITRTQAR---CRGFLARVEYQRM------VERREAIFCIQYNIR 825 Query: 430 --LKEKHSELVHVHAEL--LRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESEL 485 + KH + + ++ L K+A+T K++ +EE ++K++LA + E ++E E Sbjct: 826 SFMNVKHWPWMKLFFKIKPLLKSAETEKEMAT---MKEEFQKIKDELA-KSEAKRKELEE 881 Query: 486 KLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQ 545 K+ + L+ +++A+A LA A+E ++K +L +++ V + Sbjct: 882 KMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIK-----------EVTE 930 Query: 546 READLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLR 605 R D + + + L E ++ +L+ LA+ E ++ + ++ Sbjct: 931 RAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK--------VK 982 Query: 606 GAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADA 665 E AG L + ++KL ++ ++A L+E H Q L L Sbjct: 983 NLTEEMAG-LDETIAKL----------------TKEKKA------LQEAHQQTLDDLQAE 1019 Query: 666 SALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQAL 725 V LT+ ++ +D +L G L+ ++ L Sbjct: 1020 EDKVNTLTK-------------------AKIKLEQQVD----------DLEGSLEQEKKL 1050 Query: 726 RHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMM 785 R M + L+G L+L QE +D+ E+ +D+++ I + +IED Sbjct: 1051 R-MDLERAKRKLEGDLKLAQE---SIMDIENEK--QQLDEKLKKKEFEISNLQSKIED-- 1102 Query: 786 NQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKN 845 + G++L+ K I+ L L++EI A ++ + Sbjct: 1103 ----EQALGIQLQ-------------KKIKELQARIEELEEEIEAERASRAKAEKQRSDL 1145 Query: 846 SRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKA 905 SR E + + G GAT + ++ ++ + E ++ +T Q A + Sbjct: 1146 SRELEEISERLEEAG-GAT-----SAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1199 Query: 906 NKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQV 965 KH+ ++ L E + + + +I+D S + + K +E Sbjct: 1200 KKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL----ASNVETVSKAKGNLEKMC 1255 Query: 966 RVLELE----KTLEAERMRL-GELRKQHYVLAGASG 996 R LE + K+ E E+ RL +L Q L SG Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESG 1291 Score = 41.2 bits (95), Expect = 0.005 Identities = 47/205 (22%), Positives = 103/205 (50%), Gaps = 20/205 (9%) Query: 337 ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHEL 396 + L+ ++ ++ E+E I EA+ + K + + E+ K++Q E+++ + Sbjct: 1734 KKLETDISQMQGEMEDILQEARNAEEKAKKAITDA-AMMAEELKKEQDTSAHLERMKKNM 1792 Query: 397 AQ-LRAAQLEGERSQGLREEAERKA-SATEARYNKLKEKHSELVHVHAEL---LRKNADT 451 Q ++ QL + ++ L + +K EAR +L+ + +AE LRK+ Sbjct: 1793 EQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERR 1852 Query: 452 AKQLTV-TQQSQEEVARVK---EQLAFQVEQVKRESELKLEEKSD----QLEKLKRELEA 503 K+LT T++ ++ + R++ ++L +V+ KR++E + EE+S+ + KL+ ELE Sbjct: 1853 VKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE-EAEEQSNTNLAKFRKLQHELEE 1911 Query: 504 KAGELARAQEALSHTEQSKSELSSR 528 A + ++ ++ +K + SR Sbjct: 1912 -----AEERADIAESQVNKLRVKSR 1931 Score = 40.8 bits (94), Expect = 0.007 Identities = 35/122 (28%), Positives = 62/122 (50%), Gaps = 15/122 (12%) Query: 326 GSVKDDRDLQIESLK--REVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQ 383 G V+ ++ E++K R+ E EL E ++ I +L+ V+ L+ +++ ++Q + Sbjct: 1830 GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE 1889 Query: 384 KALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 443 +A EQ LA+ R Q E EEAE +A E++ NKL+ K E VH + Sbjct: 1890 EA---EEQSNTNLAKFRKLQHE-------LEEAEERADIAESQVNKLRVKSRE---VHTK 1936 Query: 444 LL 445 ++ Sbjct: 1937 VI 1938 Score = 38.1 bits (87), Expect = 0.044 Identities = 33/141 (23%), Positives = 69/141 (48%), Gaps = 6/141 (4%) Query: 336 IESLKREVEMLRSELEKIKLEA-QRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 394 +E +++++ E E++ L+ ++ I +L+++V LEGE+E ++K+ +A+ + Sbjct: 1792 MEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHER 1851 Query: 395 ELAQLRAAQLEGERSQGLR-EEAERKASATEARYNKLKEKHSELVHVHAELLRK---NAD 450 + +L Q E +R LR ++ K A Y + E+ E + + RK + Sbjct: 1852 RVKEL-TYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELE 1910 Query: 451 TAKQLTVTQQSQEEVARVKEQ 471 A++ +SQ RVK + Sbjct: 1911 EAEERADIAESQVNKLRVKSR 1931 >gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo sapiens] Length = 1941 Score = 79.7 bits (195), Expect = 1e-14 Identities = 168/778 (21%), Positives = 321/778 (41%), Gaps = 132/778 (16%) Query: 329 KDDRDLQIESLKREVEMLRSELEK---IKLEAQRYIAQLKSQVNALEGELEEQRKQKQKA 385 K D +++ + E+ L+S++E + ++ Q+ I +L++++ LE E+E +R + KA Sbjct: 1079 KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKA 1138 Query: 386 LVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVH---- 441 L EL ++ E + + E +K EA + K++ E H Sbjct: 1139 EKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR---EAEFQKMRRDLEEATLQHEATA 1195 Query: 442 AELLRKNADTAKQL--------TVTQQSQEEVARVK---EQLAFQVEQVKRE-------- 482 A L +K+AD+ +L V Q+ ++E + +K + LA VE V + Sbjct: 1196 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMC 1255 Query: 483 -------SELKLEEKSDQ-----LEKLKRELEAKAGELARA---QEAL-SHTEQSKSELS 526 SELK +E+ Q L + L+ ++GE +R +EAL S + K + Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFT 1315 Query: 527 SRLDTLSAE-------KDALSGAVR--QREADLLAAQ-SLVRETEAALSRE--------- 567 +++ L + K+AL+ A++ + + DLL Q +E++A L R Sbjct: 1316 QQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVA 1375 Query: 568 QQRSSQEQGELQGRLAERESQEQGLRQRL--LDEQFAVLRGAAAEAAGILQDAVSKLDD- 624 Q R+ E +Q R E E ++ L QRL +E + A Q ++++D Sbjct: 1376 QWRTKYETDAIQ-RTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDL 1434 Query: 625 PLHLRCTSSPDYLVSRAQEALDAV-----STLEEGHAQYLTSLADASALVAALTRFSHLA 679 L + T++ + + Q D + EE HA+ S +A +L L + + Sbjct: 1435 MLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAY 1494 Query: 680 ADTI--INGGATSHLAPTDPADRLIDTCRECGARA--------------LELMGQLQDQQ 723 +++ + + L + E G R EL L++ + Sbjct: 1495 EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAE 1554 Query: 724 A-LRHMQASLVRTPL---QGILQLGQELKPKSLDVRQ---------EELGAVVDKEMAAT 770 A L H + ++R L Q ++ +++ K ++ Q E + + +D E+ + Sbjct: 1555 ASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSR 1614 Query: 771 SAAI------EDAVRRIEDMMNQA-RHASSGVKLEVNER------------ILNSCTDLM 811 + AI E + +E +N A R A+ ++ N + L S DL Sbjct: 1615 NDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLK 1674 Query: 812 KAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAAD 871 + + ++ + LQ EI E AT ++ + L+ AS+ V QL+ + Sbjct: 1675 EQLAMVERRANLLQAEIEEL---RATLEQTERSRKIAEQELLDASERV-----QLLHTQN 1726 Query: 872 KVVLHTGKYEELIVCSHE-IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVV 930 +++T K E + + Q ++ KA K + + E + + +A++ Sbjct: 1727 TSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1786 Query: 931 ASTKSGQEQIEDRDTM--DFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRK 986 K+ ++ ++D + L+L KKQ + + RV ELE +E+E+ R E K Sbjct: 1787 RMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVK 1844 Score = 68.2 bits (165), Expect = 4e-11 Identities = 147/695 (21%), Positives = 273/695 (39%), Gaps = 83/695 (11%) Query: 328 VKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALV 387 +K+ DLQ++ +++E E + +R +K+++ +LE + K+ + Sbjct: 887 LKEKNDLQLQ--------VQAEAEGLADAEERCDQLIKTKI-----QLEAKIKEVTERAE 933 Query: 388 DNEQLRHELAQLRAAQLEGERSQGLRE---------EAERKASATEARYNKLKEKHSELV 438 D E++ EL + +LE E S+ ++ + E++ ATE + L E+ + L Sbjct: 934 DEEEINAELTA-KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 992 Query: 439 HVHAELLR--KNADTAKQLTVTQQSQEE-----VARVKEQLAFQVEQVKRESELKLEEKS 491 A+L + K A Q T+ EE + + K +L QV+ ++ E + + + Sbjct: 993 ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRM 1052 Query: 492 DQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLL 551 D LE+ KR+LE G+L AQE++ E K +L +L E L + +A + Sbjct: 1053 D-LERAKRKLE---GDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGI 1108 Query: 552 AAQSLVRETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRG 606 Q ++E +A + E +R+S+ + E Q RE +E + +RL Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE--ISERL---------- 1156 Query: 607 AAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA--- 663 E AG A +++ L + +TL + HA + L Sbjct: 1157 ---EEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQI 1213 Query: 664 DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 723 D V I+ A++ + L CR + EL + ++QQ Sbjct: 1214 DNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQ 1273 Query: 724 ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIED 783 L + T +G LQ + LD +E L + + + A + IE+ R++E+ Sbjct: 1274 RLIN-----DLTAQRGRLQTESGEFSRQLD-EKEALVSQLSRGKQAFTQQIEELKRQLEE 1327 Query: 784 MM---NQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQE 840 + N HA + + C L + + LQ+ + ++ A + Sbjct: 1328 EIKAKNALAHALQSSR--------HDCDLLREQYEEEQESKAELQRALSKANTEVAQWRT 1379 Query: 841 FYAKNS-RWTEGLISASKAVG---WGATQLVEAADKVVLHTGKYEELIVCSHE-----IA 891 Y ++ + TE L A K + A + VEA + K ++ + E + Sbjct: 1380 KYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVE 1439 Query: 892 ASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGL 951 + A A K + N Q+C T E A+ + G E + ++ + S Sbjct: 1440 RTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLD 1499 Query: 952 SLIKLKKQEMETQVRVLELEKTLEAERMRLGELRK 986 L LK++ Q + +L + + R+ EL K Sbjct: 1500 QLETLKRENKNLQQEISDLTEQIAEGGKRIHELEK 1534 Score = 60.8 bits (146), Expect = 6e-09 Identities = 137/711 (19%), Positives = 282/711 (39%), Gaps = 90/711 (12%) Query: 334 LQIESLKREV-------EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKAL 386 +Q+E+ +EV E + +EL K + + ++LK ++ LE L + K+K Sbjct: 919 IQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATE 978 Query: 387 VDNEQLRHELAQLRAAQLEGERSQGLREEAERKA----SATEARYNKLKEKHSELVHVHA 442 + L E+A L + + + +EA ++ A E + N L + +L Sbjct: 979 NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVD 1038 Query: 443 EL---------LRKNADTAKQ-----LTVTQQSQEEVARVKEQL-------AFQVEQVKR 481 +L LR + + AK+ L + Q+S ++ K+QL F++ ++ Sbjct: 1039 DLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQS 1098 Query: 482 ESE----------LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDT 531 + E K++E ++E+L+ E+EA+ A+A++ S + E+S RL+ Sbjct: 1099 KIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1158 Query: 532 LSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSS---QEQGELQGRLAERESQ 588 A ++REA+ Q + R+ E A + + ++ ++ + L E+ Sbjct: 1159 AGGATSAQIEMNKKREAEF---QKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDN 1215 Query: 589 EQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL-----VSRAQE 643 Q ++Q+L E+ + A+ + + VSK L C + D L Q+ Sbjct: 1216 LQRVKQKLEKEKSEMKMEIDDLASNV--ETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQ 1273 Query: 644 ALDAVSTLEEGHAQ-----YLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPA 698 L T + G Q + L + ALV+ L+R I L A Sbjct: 1274 RLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEE--LKRQLEEEIKA 1331 Query: 699 DRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDV--RQ 756 + + +L+ + +++ + +A L R + ++ Q D R Sbjct: 1332 KNALAHALQSSRHDCDLLREQYEEE--QESKAELQRALSKANTEVAQWRTKYETDAIQRT 1389 Query: 757 EELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRL 816 EEL K++A A E+ V +A +A + +R+ N DLM + Sbjct: 1390 EEL-EEAKKKLAQRLQAAEEHV--------EAVNAKCASLEKTKQRLQNEVEDLMLDVER 1440 Query: 817 LVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVV-- 874 +L K+ + A ++ + E ++++G ++ A ++ + Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ 1500 Query: 875 LHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTK 934 L T K E + EI+ T Q+ K + L++ + V + + A+ + Sbjct: 1501 LETLKRENKNL-QQEISDLTEQIAEGGK--------RIHELEKIKKQVEQEKCELQAALE 1551 Query: 935 SGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELR 985 + +E + + I+L+ +++++V EK E ++++ +R Sbjct: 1552 EAEASLEHEE----GKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIR 1598 Score = 50.1 bits (118), Expect = 1e-05 Identities = 107/508 (21%), Positives = 213/508 (41%), Gaps = 103/508 (20%) Query: 399 LRAAQLEGERSQGLREEAER---KASATEARYNKLKEKHSELVHVHAELLRKNADTAKQL 455 L++A+ E E + ++EE ++ + + +EA+ +L+EK L+ +L + A+ L Sbjct: 846 LKSAETEKEMAT-MKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904 Query: 456 TVTQQSQEEVARVKEQLAFQVEQVKRESE-------------LKLEEKSDQLEKLKRELE 502 ++ +++ + K QL ++++V +E KLE++ +L+K +LE Sbjct: 905 ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 964 Query: 503 AKAGELARAQEALSHTEQSKSELSSRLD----TLSAEKDALSGAVRQREADLLAAQSLVR 558 ++ + + A + ++ +E + LD L+ EK AL A +Q DL A + V Sbjct: 965 LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVN 1024 Query: 559 E-TEAALSREQQRSSQE--------------------QGEL---QGRLAERESQEQGLRQ 594 T+A + EQQ E +G+L Q + + E+++Q L + Sbjct: 1025 TLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDE 1084 Query: 595 RLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEG 654 +L ++F + + SK++D L L + +E + LEE Sbjct: 1085 KLKKKEFEI------------SNLQSKIEDEQALGI-----QLQKKIKELQARIEELEEE 1127 Query: 655 HAQYLTSLADASALVAALTRFSHLAADTIIN-GGATSHLAPTDPADRLIDTCRECGARAL 713 S A A + L+R ++ + GGATS A ++ RE Sbjct: 1128 IEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS-------AQIEMNKKREA---EF 1177 Query: 714 ELMGQLQDQQALRH--MQASLVRTPLQGILQLGQELK-----PKSLDVRQEELGAVVD-- 764 + M + ++ L+H A+L + + +LG+++ + L+ + E+ +D Sbjct: 1178 QKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL 1237 Query: 765 ----KEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 820 + ++ +E R +ED +++ + K E +R++N DL L T Sbjct: 1238 ASNVETVSKAKGNLEKMCRTLEDQLSELKS-----KEEEQQRLIN---DLTAQRGRLQTE 1289 Query: 821 STSLQKEIVES---------GRGAATQQ 839 S +++ E G+ A TQQ Sbjct: 1290 SGEFSRQLDEKEALVSQLSRGKQAFTQQ 1317 Score = 46.2 bits (108), Expect = 2e-04 Identities = 129/636 (20%), Positives = 247/636 (38%), Gaps = 129/636 (20%) Query: 371 LEGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNK- 429 L G LEE R K L+ Q R + A++E +R ER+ + +YN Sbjct: 775 LLGLLEEMRDDKLAQLITRTQAR---CRGFLARVEYQRM------VERREAIFCIQYNIR 825 Query: 430 --LKEKHSELVHVHAEL--LRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESEL 485 + KH + + ++ L K+A+T K++ +EE ++K++LA + E ++E E Sbjct: 826 SFMNVKHWPWMKLFFKIKPLLKSAETEKEMAT---MKEEFQKIKDELA-KSEAKRKELEE 881 Query: 486 KLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQ 545 K+ + L+ +++A+A LA A+E ++K +L +++ V + Sbjct: 882 KMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIK-----------EVTE 930 Query: 546 READLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLR 605 R D + + + L E ++ +L+ LA+ E ++ + ++ Sbjct: 931 RAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK--------VK 982 Query: 606 GAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADA 665 E AG L + ++KL ++ ++A L+E H Q L L Sbjct: 983 NLTEEMAG-LDETIAKL----------------TKEKKA------LQEAHQQTLDDLQAE 1019 Query: 666 SALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQAL 725 V LT+ ++ +D +L G L+ ++ L Sbjct: 1020 EDKVNTLTK-------------------AKIKLEQQVD----------DLEGSLEQEKKL 1050 Query: 726 RHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMM 785 R M + L+G L+L QE +D+ E+ +D+++ I + +IED Sbjct: 1051 R-MDLERAKRKLEGDLKLAQE---SIMDIENEK--QQLDEKLKKKEFEISNLQSKIED-- 1102 Query: 786 NQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKN 845 + G++L+ K I+ L L++EI A ++ + Sbjct: 1103 ----EQALGIQLQ-------------KKIKELQARIEELEEEIEAERASRAKAEKQRSDL 1145 Query: 846 SRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKA 905 SR E + + G GAT + ++ ++ + E ++ +T Q A + Sbjct: 1146 SRELEEISERLEEAG-GAT-----SAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1199 Query: 906 NKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQV 965 KH+ ++ L E + + + +I+D S + + K +E Sbjct: 1200 KKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL----ASNVETVSKAKGNLEKMC 1255 Query: 966 RVLELE----KTLEAERMRL-GELRKQHYVLAGASG 996 R LE + K+ E E+ RL +L Q L SG Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESG 1291 Score = 41.2 bits (95), Expect = 0.005 Identities = 47/205 (22%), Positives = 103/205 (50%), Gaps = 20/205 (9%) Query: 337 ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHEL 396 + L+ ++ ++ E+E I EA+ + K + + E+ K++Q E+++ + Sbjct: 1734 KKLETDISQMQGEMEDILQEARNAEEKAKKAITDA-AMMAEELKKEQDTSAHLERMKKNM 1792 Query: 397 AQ-LRAAQLEGERSQGLREEAERKA-SATEARYNKLKEKHSELVHVHAEL---LRKNADT 451 Q ++ QL + ++ L + +K EAR +L+ + +AE LRK+ Sbjct: 1793 EQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERR 1852 Query: 452 AKQLTV-TQQSQEEVARVK---EQLAFQVEQVKRESELKLEEKSD----QLEKLKRELEA 503 K+LT T++ ++ + R++ ++L +V+ KR++E + EE+S+ + KL+ ELE Sbjct: 1853 VKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE-EAEEQSNTNLAKFRKLQHELEE 1911 Query: 504 KAGELARAQEALSHTEQSKSELSSR 528 A + ++ ++ +K + SR Sbjct: 1912 -----AEERADIAESQVNKLRVKSR 1931 Score = 40.8 bits (94), Expect = 0.007 Identities = 35/122 (28%), Positives = 62/122 (50%), Gaps = 15/122 (12%) Query: 326 GSVKDDRDLQIESLK--REVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQ 383 G V+ ++ E++K R+ E EL E ++ I +L+ V+ L+ +++ ++Q + Sbjct: 1830 GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE 1889 Query: 384 KALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 443 +A EQ LA+ R Q E EEAE +A E++ NKL+ K E VH + Sbjct: 1890 EA---EEQSNTNLAKFRKLQHE-------LEEAEERADIAESQVNKLRVKSRE---VHTK 1936 Query: 444 LL 445 ++ Sbjct: 1937 VI 1938 Score = 38.1 bits (87), Expect = 0.044 Identities = 33/141 (23%), Positives = 69/141 (48%), Gaps = 6/141 (4%) Query: 336 IESLKREVEMLRSELEKIKLEA-QRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 394 +E +++++ E E++ L+ ++ I +L+++V LEGE+E ++K+ +A+ + Sbjct: 1792 MEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHER 1851 Query: 395 ELAQLRAAQLEGERSQGLR-EEAERKASATEARYNKLKEKHSELVHVHAELLRK---NAD 450 + +L Q E +R LR ++ K A Y + E+ E + + RK + Sbjct: 1852 RVKEL-TYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELE 1910 Query: 451 TAKQLTVTQQSQEEVARVKEQ 471 A++ +SQ RVK + Sbjct: 1911 EAEERADIAESQVNKLRVKSR 1931 >gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] Length = 2003 Score = 79.0 bits (193), Expect = 2e-14 Identities = 167/775 (21%), Positives = 300/775 (38%), Gaps = 135/775 (17%) Query: 330 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNA--------------LEGEL 375 +DR + S E E L K++L+ + IA ++ ++ L+GE Sbjct: 1030 EDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGES 1089 Query: 376 EEQRKQKQKALVDNEQLRHEL---------AQLRAAQLEGERSQGLREEAERKASATEAR 426 E ++Q + E+LR +L A RA G R+Q L+ E +A+ EA+ Sbjct: 1090 SELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ 1149 Query: 427 YNKLKEK-------------HSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLA 473 + E+ EL + EL T Q + + ++EV +K+ L Sbjct: 1150 EDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLE 1209 Query: 474 FQ-------VEQVKRESELKLEEKSDQLEKLKR----------ELEAKAGELARAQEALS 516 + V+++++ L E ++QLE+ +R LEA+ EL +L Sbjct: 1210 EETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQ 1269 Query: 517 HT-------------------------EQSKSELSSRLDTLSAEKDALSGAVRQREADLL 551 E++++E + +L AE + +SGA+ + E+ + Sbjct: 1270 TARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTI 1329 Query: 552 AAQSLVRETEAALSREQ---QRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAA 608 + TEA L Q Q ++ + L R+ E++ GLR++L +E AA Sbjct: 1330 RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE------AAA 1383 Query: 609 AEAAG-ILQDAVSKLD----------------DPLHLRCTSSPDYLVSRAQEALDAVSTL 651 E AG LQ A ++L + R + L R E + V L Sbjct: 1384 RERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRL 1443 Query: 652 EEGHAQYLTSLADAS-------ALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDT 704 E G + L DA+ LV+ L + D ++ + L + +R Sbjct: 1444 ERGRRRLQQELDDATMDLEQQRQLVSTLEK-KQRKFDQLLAEEKAAVLRAVEERERAEAE 1502 Query: 705 CRECGARALELMGQLQDQQALR---HMQASLVRTPLQGILQLGQELKPKSLDVRQEELGA 761 RE ARAL L L+++Q R Q +R L+ +L ++ V + E Sbjct: 1503 GREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDV---GKSVHELERAC 1559 Query: 762 VVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTS 821 V ++ A A V +ED + A A ++LEV + L T + ++ Sbjct: 1560 RVAEQAANDLRA---QVTELEDELTAAEDAK--LRLEVTVQALK--TQHERDLQGRDEAG 1612 Query: 822 TSLQKEIVESGRGAATQQEFYAKN-------SRWTEGLISASKAVGWGATQLVEAADKVV 874 ++++ + R A +++ K + EG + KA A Q E A K + Sbjct: 1613 EERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQL 1672 Query: 875 LHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTK 934 + + E ++ + + + ++ K L E R E AA+ A + Sbjct: 1673 RKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLE--AEVLRLQEELAASDRARRQ 1730 Query: 935 SGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHY 989 + Q++ E D + LS + +++ + + R+ +LE+ LE E+ EL Y Sbjct: 1731 AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN-SELLNDRY 1784 Score = 78.6 bits (192), Expect = 3e-14 Identities = 161/694 (23%), Positives = 280/694 (40%), Gaps = 99/694 (14%) Query: 335 QIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 394 ++ + K+E+E++ SELE A GE EE +Q Q + ++L+ Sbjct: 937 RLAARKQELELVVSELE------------------ARVGEEEECSRQMQ---TEKKRLQQ 975 Query: 395 ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 454 + +L A LE E +G R++ + + TEA+ K +E L +++L ++ + Sbjct: 976 HIQELE-AHLEAE--EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDR 1032 Query: 455 LT-VTQQSQEEVARVKE----QLAFQVEQVKRESELKLEEKSDQ-LEKLKRELEAKAGEL 508 L + Q+ EE +VK +L ++ E L+ EEK Q LEKLKR L+ ++ EL Sbjct: 1033 LAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSEL 1092 Query: 509 ARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQ 568 QE + +Q EL ++L E A +RE +AAL+ Q Sbjct: 1093 ---QEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ 1149 Query: 569 QRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA---AAEAAGILQDAVSKLDDP 625 + E R+A ++++Q +R L E+ LRG ++ Q+ SK + Sbjct: 1150 EDLESE------RVARTKAEKQ---RRDLGEELEALRGELEDTLDSTNAQQELRSKREQE 1200 Query: 626 L-HLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVA------ALTRFSHL 678 + L+ T + +R EA AV L + H Q L LA+ TR + Sbjct: 1201 VTELKKTLEEE---TRIHEA--AVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALE 1255 Query: 679 AADTIINGGATSHLAPTDPADRLIDTCRECG---ARALELMGQLQDQQALRHMQASLVRT 735 A + + +S + T R+ G R LEL QLQ+ Q R R Sbjct: 1256 AEVSELRAELSS-----------LQTARQEGEQRRRRLEL--QLQEVQG-RAGDGERARA 1301 Query: 736 PLQGILQLGQ-ELKPKSLDVRQEELGAV-VDKEMAATSAAIEDAVRRIEDMMNQARHASS 793 LQ Q EL+ S + + E + + KE+++T A + DA +++ S Sbjct: 1302 EAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS 1361 Query: 794 GVK------LEVNERILNSCTDLMKAIRLLVTTSTSL----QKEIVESG---RGAATQQE 840 V+ + E++ +A R L T L +++ E+G G ++ Sbjct: 1362 RVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRR 1421 Query: 841 FYAKNSRWTEGLISASKAVG---WGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQL 897 + T+ L ++ V G +L + D + + +L+ + QL Sbjct: 1422 AAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQL 1481 Query: 898 VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSG----LSL 953 +A K + R + R ER A ++ T++ +E+ E R+ ++ L Sbjct: 1482 LAEEKAAVLRAVEERERAEAEGR---EREARALSLTRALEEEQEAREELERQNRALRAEL 1538 Query: 954 IKLKKQEMETQVRVLELEKTLEAERMRLGELRKQ 987 L + + V ELE+ +LR Q Sbjct: 1539 EALLSSKDDVGKSVHELERACRVAEQAANDLRAQ 1572 Score = 62.0 bits (149), Expect = 3e-09 Identities = 72/271 (26%), Positives = 121/271 (44%), Gaps = 28/271 (10%) Query: 367 QVNALEGELEEQRKQKQKALVDNEQLRHELAQL--RAAQLEGERS---QGLREEAERKAS 421 QV + L+ + ++ QK +Q E+ +L R AQLE ER+ + LR EAE A Sbjct: 871 QVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAE 930 Query: 422 ATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKR 481 A E R +L + EL V +EL A ++ ++Q Q E R+++ + + Sbjct: 931 AEETR-GRLAARKQELELVVSEL---EARVGEEEECSRQMQTEKKRLQQHI--------Q 978 Query: 482 ESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSG 541 E E LE + +KL+ E ++ + +E L E S+LS L S Sbjct: 979 ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSS 1038 Query: 542 AVRQREADLLAAQSLVRETEAALS------REQQRSSQEQGELQGRL--AERESQEQGLR 593 + E + + L + EA ++ R++++ QE +L+ RL E QEQ + Sbjct: 1039 QAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVE 1098 Query: 594 QRLLDEQFAVLRGAAAEAAGILQDAVSKLDD 624 Q+ E+ G E LQ A+++ +D Sbjct: 1099 QQQRAEELRAQLGRKEEE---LQAALARAED 1126 Score = 62.0 bits (149), Expect = 3e-09 Identities = 72/281 (25%), Positives = 123/281 (43%), Gaps = 42/281 (14%) Query: 330 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 389 ++R Q+ R+ E+ R E K QR +A + LEGELEE + Q A Sbjct: 1613 EERRRQLAKQLRDAEVERDEERK-----QRTLAVAARK--KLEGELEELKAQMASAGQGK 1665 Query: 390 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 449 E+ +L +++A E L E E ++ E +++ +E L + AE+LR Sbjct: 1666 EEAVKQLRKMQAQMKE------LWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQE 1719 Query: 450 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELA 509 + A +Q+Q++ ++++A +V LEE KR+LE + G+L Sbjct: 1720 ELAASDRARRQAQQD----RDEMADEVANGNLSKAAILEE--------KRQLEGRLGQLE 1767 Query: 510 RAQEALSHTEQSKSELSS--------RLDTLSAEKDALSGAVRQREADLLAAQSLVRETE 561 E EQS SEL + ++++L+ E A + E+ + ++E Sbjct: 1768 EELE----EEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELR 1823 Query: 562 AALSRE----QQRSSQEQGELQGRLAERESQ-EQGLRQRLL 597 L E + R L+ +LA+ E Q EQ R+R+L Sbjct: 1824 GRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERIL 1864 Score = 53.9 bits (128), Expect = 8e-07 Identities = 58/293 (19%), Positives = 131/293 (44%), Gaps = 23/293 (7%) Query: 326 GSVKDDRDLQIESLKREVEMLRSELEKIKL----------EAQRYIAQLKSQVNALEGEL 375 G K++ Q+ ++ +++ L E+E+ + E+++ + L+++V L+ EL Sbjct: 1662 GQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEEL 1721 Query: 376 EEQRKQKQKALVDNEQLRHELAQ---LRAA------QLEGERSQGLREEAERKASATEAR 426 + +++A D +++ E+A +AA QLEG Q L EE E + S +E Sbjct: 1722 AASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQ-LEEELEEEQSNSELL 1780 Query: 427 YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELK 486 ++ ++ ++ + EL + + +AK + QQ + ++ ++ +L + + ++ Sbjct: 1781 NDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMT 1840 Query: 487 LEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQR 546 + +L + + +LE + E + + + E+ E+ +++ D L + + Sbjct: 1841 IAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKG 1900 Query: 547 EADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQ---GLRQRL 596 + + + E E SR Q + Q EL+ ES + LR RL Sbjct: 1901 NLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRL 1953 Score = 52.0 bits (123), Expect = 3e-06 Identities = 55/235 (23%), Positives = 102/235 (43%), Gaps = 22/235 (9%) Query: 344 EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRAAQ 403 E L E +L RY +L QV +L EL +R KA +QL ++ +LR Sbjct: 1768 EELEEEQSNSELLNDRY-RKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1826 Query: 404 LEGERSQGLREEAERKASATEARYNKLKEKHSELVH---VHAELLRKNADTAKQLTVTQQ 460 GE G R + +A E++ + +E+ + + +L+R+ K++ + Sbjct: 1827 --GEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVL--- 1881 Query: 461 SQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQ 520 EE RV +QL Q LE+ + ++++LKR+LE E +RAQ ++ Sbjct: 1882 QVEEERRVADQLRDQ-----------LEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQR 1930 Query: 521 SKSELSSRLDTLSAEKDALSGAVRQREADLL--AAQSLVRETEAALSREQQRSSQ 573 +++ ++++ E L +R+ + + R E S E+ +Q Sbjct: 1931 ELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQ 1985 >gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] Length = 1995 Score = 79.0 bits (193), Expect = 2e-14 Identities = 167/775 (21%), Positives = 300/775 (38%), Gaps = 135/775 (17%) Query: 330 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNA--------------LEGEL 375 +DR + S E E L K++L+ + IA ++ ++ L+GE Sbjct: 1022 EDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGES 1081 Query: 376 EEQRKQKQKALVDNEQLRHEL---------AQLRAAQLEGERSQGLREEAERKASATEAR 426 E ++Q + E+LR +L A RA G R+Q L+ E +A+ EA+ Sbjct: 1082 SELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ 1141 Query: 427 YNKLKEK-------------HSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLA 473 + E+ EL + EL T Q + + ++EV +K+ L Sbjct: 1142 EDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLE 1201 Query: 474 FQ-------VEQVKRESELKLEEKSDQLEKLKR----------ELEAKAGELARAQEALS 516 + V+++++ L E ++QLE+ +R LEA+ EL +L Sbjct: 1202 EETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQ 1261 Query: 517 HT-------------------------EQSKSELSSRLDTLSAEKDALSGAVRQREADLL 551 E++++E + +L AE + +SGA+ + E+ + Sbjct: 1262 TARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTI 1321 Query: 552 AAQSLVRETEAALSREQ---QRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAA 608 + TEA L Q Q ++ + L R+ E++ GLR++L +E AA Sbjct: 1322 RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE------AAA 1375 Query: 609 AEAAG-ILQDAVSKLD----------------DPLHLRCTSSPDYLVSRAQEALDAVSTL 651 E AG LQ A ++L + R + L R E + V L Sbjct: 1376 RERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRL 1435 Query: 652 EEGHAQYLTSLADAS-------ALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDT 704 E G + L DA+ LV+ L + D ++ + L + +R Sbjct: 1436 ERGRRRLQQELDDATMDLEQQRQLVSTLEK-KQRKFDQLLAEEKAAVLRAVEERERAEAE 1494 Query: 705 CRECGARALELMGQLQDQQALR---HMQASLVRTPLQGILQLGQELKPKSLDVRQEELGA 761 RE ARAL L L+++Q R Q +R L+ +L ++ V + E Sbjct: 1495 GREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDV---GKSVHELERAC 1551 Query: 762 VVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTS 821 V ++ A A V +ED + A A ++LEV + L T + ++ Sbjct: 1552 RVAEQAANDLRA---QVTELEDELTAAEDAK--LRLEVTVQALK--TQHERDLQGRDEAG 1604 Query: 822 TSLQKEIVESGRGAATQQEFYAKN-------SRWTEGLISASKAVGWGATQLVEAADKVV 874 ++++ + R A +++ K + EG + KA A Q E A K + Sbjct: 1605 EERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQL 1664 Query: 875 LHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTK 934 + + E ++ + + + ++ K L E R E AA+ A + Sbjct: 1665 RKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLE--AEVLRLQEELAASDRARRQ 1722 Query: 935 SGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHY 989 + Q++ E D + LS + +++ + + R+ +LE+ LE E+ EL Y Sbjct: 1723 AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN-SELLNDRY 1776 Score = 78.6 bits (192), Expect = 3e-14 Identities = 161/694 (23%), Positives = 280/694 (40%), Gaps = 99/694 (14%) Query: 335 QIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 394 ++ + K+E+E++ SELE A GE EE +Q Q + ++L+ Sbjct: 929 RLAARKQELELVVSELE------------------ARVGEEEECSRQMQ---TEKKRLQQ 967 Query: 395 ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 454 + +L A LE E +G R++ + + TEA+ K +E L +++L ++ + Sbjct: 968 HIQELE-AHLEAE--EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDR 1024 Query: 455 LT-VTQQSQEEVARVKE----QLAFQVEQVKRESELKLEEKSDQ-LEKLKRELEAKAGEL 508 L + Q+ EE +VK +L ++ E L+ EEK Q LEKLKR L+ ++ EL Sbjct: 1025 LAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSEL 1084 Query: 509 ARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQ 568 QE + +Q EL ++L E A +RE +AAL+ Q Sbjct: 1085 ---QEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ 1141 Query: 569 QRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA---AAEAAGILQDAVSKLDDP 625 + E R+A ++++Q +R L E+ LRG ++ Q+ SK + Sbjct: 1142 EDLESE------RVARTKAEKQ---RRDLGEELEALRGELEDTLDSTNAQQELRSKREQE 1192 Query: 626 L-HLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVA------ALTRFSHL 678 + L+ T + +R EA AV L + H Q L LA+ TR + Sbjct: 1193 VTELKKTLEEE---TRIHEA--AVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALE 1247 Query: 679 AADTIINGGATSHLAPTDPADRLIDTCRECG---ARALELMGQLQDQQALRHMQASLVRT 735 A + + +S + T R+ G R LEL QLQ+ Q R R Sbjct: 1248 AEVSELRAELSS-----------LQTARQEGEQRRRRLEL--QLQEVQG-RAGDGERARA 1293 Query: 736 PLQGILQLGQ-ELKPKSLDVRQEELGAV-VDKEMAATSAAIEDAVRRIEDMMNQARHASS 793 LQ Q EL+ S + + E + + KE+++T A + DA +++ S Sbjct: 1294 EAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS 1353 Query: 794 GVK------LEVNERILNSCTDLMKAIRLLVTTSTSL----QKEIVESG---RGAATQQE 840 V+ + E++ +A R L T L +++ E+G G ++ Sbjct: 1354 RVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRR 1413 Query: 841 FYAKNSRWTEGLISASKAVG---WGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQL 897 + T+ L ++ V G +L + D + + +L+ + QL Sbjct: 1414 AAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQL 1473 Query: 898 VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSG----LSL 953 +A K + R + R ER A ++ T++ +E+ E R+ ++ L Sbjct: 1474 LAEEKAAVLRAVEERERAEAEGR---EREARALSLTRALEEEQEAREELERQNRALRAEL 1530 Query: 954 IKLKKQEMETQVRVLELEKTLEAERMRLGELRKQ 987 L + + V ELE+ +LR Q Sbjct: 1531 EALLSSKDDVGKSVHELERACRVAEQAANDLRAQ 1564 Score = 62.0 bits (149), Expect = 3e-09 Identities = 72/271 (26%), Positives = 121/271 (44%), Gaps = 28/271 (10%) Query: 367 QVNALEGELEEQRKQKQKALVDNEQLRHELAQL--RAAQLEGERS---QGLREEAERKAS 421 QV + L+ + ++ QK +Q E+ +L R AQLE ER+ + LR EAE A Sbjct: 863 QVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAE 922 Query: 422 ATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKR 481 A E R +L + EL V +EL A ++ ++Q Q E R+++ + + Sbjct: 923 AEETR-GRLAARKQELELVVSEL---EARVGEEEECSRQMQTEKKRLQQHI--------Q 970 Query: 482 ESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSG 541 E E LE + +KL+ E ++ + +E L E S+LS L S Sbjct: 971 ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSS 1030 Query: 542 AVRQREADLLAAQSLVRETEAALS------REQQRSSQEQGELQGRL--AERESQEQGLR 593 + E + + L + EA ++ R++++ QE +L+ RL E QEQ + Sbjct: 1031 QAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVE 1090 Query: 594 QRLLDEQFAVLRGAAAEAAGILQDAVSKLDD 624 Q+ E+ G E LQ A+++ +D Sbjct: 1091 QQQRAEELRAQLGRKEEE---LQAALARAED 1118 Score = 62.0 bits (149), Expect = 3e-09 Identities = 72/281 (25%), Positives = 123/281 (43%), Gaps = 42/281 (14%) Query: 330 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 389 ++R Q+ R+ E+ R E K QR +A + LEGELEE + Q A Sbjct: 1605 EERRRQLAKQLRDAEVERDEERK-----QRTLAVAARK--KLEGELEELKAQMASAGQGK 1657 Query: 390 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 449 E+ +L +++A E L E E ++ E +++ +E L + AE+LR Sbjct: 1658 EEAVKQLRKMQAQMKE------LWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQE 1711 Query: 450 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELA 509 + A +Q+Q++ ++++A +V LEE KR+LE + G+L Sbjct: 1712 ELAASDRARRQAQQD----RDEMADEVANGNLSKAAILEE--------KRQLEGRLGQLE 1759 Query: 510 RAQEALSHTEQSKSELSS--------RLDTLSAEKDALSGAVRQREADLLAAQSLVRETE 561 E EQS SEL + ++++L+ E A + E+ + ++E Sbjct: 1760 EELE----EEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELR 1815 Query: 562 AALSRE----QQRSSQEQGELQGRLAERESQ-EQGLRQRLL 597 L E + R L+ +LA+ E Q EQ R+R+L Sbjct: 1816 GRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERIL 1856 Score = 53.9 bits (128), Expect = 8e-07 Identities = 58/293 (19%), Positives = 131/293 (44%), Gaps = 23/293 (7%) Query: 326 GSVKDDRDLQIESLKREVEMLRSELEKIKL----------EAQRYIAQLKSQVNALEGEL 375 G K++ Q+ ++ +++ L E+E+ + E+++ + L+++V L+ EL Sbjct: 1654 GQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEEL 1713 Query: 376 EEQRKQKQKALVDNEQLRHELAQ---LRAA------QLEGERSQGLREEAERKASATEAR 426 + +++A D +++ E+A +AA QLEG Q L EE E + S +E Sbjct: 1714 AASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQ-LEEELEEEQSNSELL 1772 Query: 427 YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELK 486 ++ ++ ++ + EL + + +AK + QQ + ++ ++ +L + + ++ Sbjct: 1773 NDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMT 1832 Query: 487 LEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQR 546 + +L + + +LE + E + + + E+ E+ +++ D L + + Sbjct: 1833 IAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKG 1892 Query: 547 EADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQ---GLRQRL 596 + + + E E SR Q + Q EL+ ES + LR RL Sbjct: 1893 NLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRL 1945 Score = 52.0 bits (123), Expect = 3e-06 Identities = 55/235 (23%), Positives = 102/235 (43%), Gaps = 22/235 (9%) Query: 344 EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRAAQ 403 E L E +L RY +L QV +L EL +R KA +QL ++ +LR Sbjct: 1760 EELEEEQSNSELLNDRY-RKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1818 Query: 404 LEGERSQGLREEAERKASATEARYNKLKEKHSELVH---VHAELLRKNADTAKQLTVTQQ 460 GE G R + +A E++ + +E+ + + +L+R+ K++ + Sbjct: 1819 --GEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVL--- 1873 Query: 461 SQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQ 520 EE RV +QL Q LE+ + ++++LKR+LE E +RAQ ++ Sbjct: 1874 QVEEERRVADQLRDQ-----------LEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQR 1922 Query: 521 SKSELSSRLDTLSAEKDALSGAVRQREADLL--AAQSLVRETEAALSREQQRSSQ 573 +++ ++++ E L +R+ + + R E S E+ +Q Sbjct: 1923 ELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQ 1977 >gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] Length = 2036 Score = 79.0 bits (193), Expect = 2e-14 Identities = 167/775 (21%), Positives = 300/775 (38%), Gaps = 135/775 (17%) Query: 330 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNA--------------LEGEL 375 +DR + S E E L K++L+ + IA ++ ++ L+GE Sbjct: 1063 EDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGES 1122 Query: 376 EEQRKQKQKALVDNEQLRHEL---------AQLRAAQLEGERSQGLREEAERKASATEAR 426 E ++Q + E+LR +L A RA G R+Q L+ E +A+ EA+ Sbjct: 1123 SELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ 1182 Query: 427 YNKLKEK-------------HSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLA 473 + E+ EL + EL T Q + + ++EV +K+ L Sbjct: 1183 EDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLE 1242 Query: 474 FQ-------VEQVKRESELKLEEKSDQLEKLKR----------ELEAKAGELARAQEALS 516 + V+++++ L E ++QLE+ +R LEA+ EL +L Sbjct: 1243 EETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQ 1302 Query: 517 HT-------------------------EQSKSELSSRLDTLSAEKDALSGAVRQREADLL 551 E++++E + +L AE + +SGA+ + E+ + Sbjct: 1303 TARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTI 1362 Query: 552 AAQSLVRETEAALSREQ---QRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAA 608 + TEA L Q Q ++ + L R+ E++ GLR++L +E AA Sbjct: 1363 RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE------AAA 1416 Query: 609 AEAAG-ILQDAVSKLD----------------DPLHLRCTSSPDYLVSRAQEALDAVSTL 651 E AG LQ A ++L + R + L R E + V L Sbjct: 1417 RERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRL 1476 Query: 652 EEGHAQYLTSLADAS-------ALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDT 704 E G + L DA+ LV+ L + D ++ + L + +R Sbjct: 1477 ERGRRRLQQELDDATMDLEQQRQLVSTLEK-KQRKFDQLLAEEKAAVLRAVEERERAEAE 1535 Query: 705 CRECGARALELMGQLQDQQALR---HMQASLVRTPLQGILQLGQELKPKSLDVRQEELGA 761 RE ARAL L L+++Q R Q +R L+ +L ++ V + E Sbjct: 1536 GREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDV---GKSVHELERAC 1592 Query: 762 VVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTS 821 V ++ A A V +ED + A A ++LEV + L T + ++ Sbjct: 1593 RVAEQAANDLRA---QVTELEDELTAAEDAK--LRLEVTVQALK--TQHERDLQGRDEAG 1645 Query: 822 TSLQKEIVESGRGAATQQEFYAKN-------SRWTEGLISASKAVGWGATQLVEAADKVV 874 ++++ + R A +++ K + EG + KA A Q E A K + Sbjct: 1646 EERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQL 1705 Query: 875 LHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTK 934 + + E ++ + + + ++ K L E R E AA+ A + Sbjct: 1706 RKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLE--AEVLRLQEELAASDRARRQ 1763 Query: 935 SGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHY 989 + Q++ E D + LS + +++ + + R+ +LE+ LE E+ EL Y Sbjct: 1764 AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN-SELLNDRY 1817 Score = 78.6 bits (192), Expect = 3e-14 Identities = 161/694 (23%), Positives = 280/694 (40%), Gaps = 99/694 (14%) Query: 335 QIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 394 ++ + K+E+E++ SELE A GE EE +Q Q + ++L+ Sbjct: 970 RLAARKQELELVVSELE------------------ARVGEEEECSRQMQ---TEKKRLQQ 1008 Query: 395 ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 454 + +L A LE E +G R++ + + TEA+ K +E L +++L ++ + Sbjct: 1009 HIQELE-AHLEAE--EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDR 1065 Query: 455 LT-VTQQSQEEVARVKE----QLAFQVEQVKRESELKLEEKSDQ-LEKLKRELEAKAGEL 508 L + Q+ EE +VK +L ++ E L+ EEK Q LEKLKR L+ ++ EL Sbjct: 1066 LAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSEL 1125 Query: 509 ARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQ 568 QE + +Q EL ++L E A +RE +AAL+ Q Sbjct: 1126 ---QEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ 1182 Query: 569 QRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA---AAEAAGILQDAVSKLDDP 625 + E R+A ++++Q +R L E+ LRG ++ Q+ SK + Sbjct: 1183 EDLESE------RVARTKAEKQ---RRDLGEELEALRGELEDTLDSTNAQQELRSKREQE 1233 Query: 626 L-HLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVA------ALTRFSHL 678 + L+ T + +R EA AV L + H Q L LA+ TR + Sbjct: 1234 VTELKKTLEEE---TRIHEA--AVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALE 1288 Query: 679 AADTIINGGATSHLAPTDPADRLIDTCRECG---ARALELMGQLQDQQALRHMQASLVRT 735 A + + +S + T R+ G R LEL QLQ+ Q R R Sbjct: 1289 AEVSELRAELSS-----------LQTARQEGEQRRRRLEL--QLQEVQG-RAGDGERARA 1334 Query: 736 PLQGILQLGQ-ELKPKSLDVRQEELGAV-VDKEMAATSAAIEDAVRRIEDMMNQARHASS 793 LQ Q EL+ S + + E + + KE+++T A + DA +++ S Sbjct: 1335 EAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS 1394 Query: 794 GVK------LEVNERILNSCTDLMKAIRLLVTTSTSL----QKEIVESG---RGAATQQE 840 V+ + E++ +A R L T L +++ E+G G ++ Sbjct: 1395 RVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRR 1454 Query: 841 FYAKNSRWTEGLISASKAVG---WGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQL 897 + T+ L ++ V G +L + D + + +L+ + QL Sbjct: 1455 AAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQL 1514 Query: 898 VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSG----LSL 953 +A K + R + R ER A ++ T++ +E+ E R+ ++ L Sbjct: 1515 LAEEKAAVLRAVEERERAEAEGR---EREARALSLTRALEEEQEAREELERQNRALRAEL 1571 Query: 954 IKLKKQEMETQVRVLELEKTLEAERMRLGELRKQ 987 L + + V ELE+ +LR Q Sbjct: 1572 EALLSSKDDVGKSVHELERACRVAEQAANDLRAQ 1605 Score = 62.0 bits (149), Expect = 3e-09 Identities = 72/271 (26%), Positives = 121/271 (44%), Gaps = 28/271 (10%) Query: 367 QVNALEGELEEQRKQKQKALVDNEQLRHELAQL--RAAQLEGERS---QGLREEAERKAS 421 QV + L+ + ++ QK +Q E+ +L R AQLE ER+ + LR EAE A Sbjct: 904 QVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAE 963 Query: 422 ATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKR 481 A E R +L + EL V +EL A ++ ++Q Q E R+++ + + Sbjct: 964 AEETR-GRLAARKQELELVVSEL---EARVGEEEECSRQMQTEKKRLQQHI--------Q 1011 Query: 482 ESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSG 541 E E LE + +KL+ E ++ + +E L E S+LS L S Sbjct: 1012 ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSS 1071 Query: 542 AVRQREADLLAAQSLVRETEAALS------REQQRSSQEQGELQGRL--AERESQEQGLR 593 + E + + L + EA ++ R++++ QE +L+ RL E QEQ + Sbjct: 1072 QAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVE 1131 Query: 594 QRLLDEQFAVLRGAAAEAAGILQDAVSKLDD 624 Q+ E+ G E LQ A+++ +D Sbjct: 1132 QQQRAEELRAQLGRKEEE---LQAALARAED 1159 Score = 62.0 bits (149), Expect = 3e-09 Identities = 72/281 (25%), Positives = 123/281 (43%), Gaps = 42/281 (14%) Query: 330 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 389 ++R Q+ R+ E+ R E K QR +A + LEGELEE + Q A Sbjct: 1646 EERRRQLAKQLRDAEVERDEERK-----QRTLAVAARK--KLEGELEELKAQMASAGQGK 1698 Query: 390 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 449 E+ +L +++A E L E E ++ E +++ +E L + AE+LR Sbjct: 1699 EEAVKQLRKMQAQMKE------LWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQE 1752 Query: 450 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELA 509 + A +Q+Q++ ++++A +V LEE KR+LE + G+L Sbjct: 1753 ELAASDRARRQAQQD----RDEMADEVANGNLSKAAILEE--------KRQLEGRLGQLE 1800 Query: 510 RAQEALSHTEQSKSELSS--------RLDTLSAEKDALSGAVRQREADLLAAQSLVRETE 561 E EQS SEL + ++++L+ E A + E+ + ++E Sbjct: 1801 EELE----EEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELR 1856 Query: 562 AALSRE----QQRSSQEQGELQGRLAERESQ-EQGLRQRLL 597 L E + R L+ +LA+ E Q EQ R+R+L Sbjct: 1857 GRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERIL 1897 Score = 53.9 bits (128), Expect = 8e-07 Identities = 58/293 (19%), Positives = 131/293 (44%), Gaps = 23/293 (7%) Query: 326 GSVKDDRDLQIESLKREVEMLRSELEKIKL----------EAQRYIAQLKSQVNALEGEL 375 G K++ Q+ ++ +++ L E+E+ + E+++ + L+++V L+ EL Sbjct: 1695 GQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEEL 1754 Query: 376 EEQRKQKQKALVDNEQLRHELAQ---LRAA------QLEGERSQGLREEAERKASATEAR 426 + +++A D +++ E+A +AA QLEG Q L EE E + S +E Sbjct: 1755 AASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQ-LEEELEEEQSNSELL 1813 Query: 427 YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELK 486 ++ ++ ++ + EL + + +AK + QQ + ++ ++ +L + + ++ Sbjct: 1814 NDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMT 1873 Query: 487 LEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQR 546 + +L + + +LE + E + + + E+ E+ +++ D L + + Sbjct: 1874 IAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKG 1933 Query: 547 EADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQ---GLRQRL 596 + + + E E SR Q + Q EL+ ES + LR RL Sbjct: 1934 NLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRL 1986 Score = 52.0 bits (123), Expect = 3e-06 Identities = 55/235 (23%), Positives = 102/235 (43%), Gaps = 22/235 (9%) Query: 344 EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRAAQ 403 E L E +L RY +L QV +L EL +R KA +QL ++ +LR Sbjct: 1801 EELEEEQSNSELLNDRY-RKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1859 Query: 404 LEGERSQGLREEAERKASATEARYNKLKEKHSELVH---VHAELLRKNADTAKQLTVTQQ 460 GE G R + +A E++ + +E+ + + +L+R+ K++ + Sbjct: 1860 --GEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVL--- 1914 Query: 461 SQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQ 520 EE RV +QL Q LE+ + ++++LKR+LE E +RAQ ++ Sbjct: 1915 QVEEERRVADQLRDQ-----------LEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQR 1963 Query: 521 SKSELSSRLDTLSAEKDALSGAVRQREADLL--AAQSLVRETEAALSREQQRSSQ 573 +++ ++++ E L +R+ + + R E S E+ +Q Sbjct: 1964 ELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQ 2018 >gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo sapiens] Length = 1940 Score = 79.0 bits (193), Expect = 2e-14 Identities = 157/718 (21%), Positives = 295/718 (41%), Gaps = 117/718 (16%) Query: 335 QIE-SLKREVEML--RSELEKIKLEAQRYIAQLKSQVNALEGELEEQ----RKQKQKALV 387 QIE + KRE E L R +LE+ L+ + +A L+ + EL EQ ++ KQK Sbjct: 1161 QIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEK 1220 Query: 388 DNEQLRHELAQLRAAQLEGERSQGLREEA----ERKASATEARYNKLKEKHSELVHVHAE 443 + + + E+ L ++ +S+ E+ E + S + +++ SEL + Sbjct: 1221 EKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSR 1280 Query: 444 LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEA 503 L + + ++QL + +++R K+ Q E++KR+ LEE++ L L++ Sbjct: 1281 LQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQ----LEEENKAKNALAHALQS 1336 Query: 504 KAGELARAQEALSHTEQSKSELSSRLDTLSAE---------KDALSGAVRQREADLLAAQ 554 + +E ++ K+EL L ++E DA+ EA AQ Sbjct: 1337 SRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1396 Query: 555 SLVRETE---------AALSREQQRSSQEQGELQGRLAERESQEQGL--RQRLLDEQFAV 603 L E A+L + +QR E +L + S L +QR D+ A Sbjct: 1397 RLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAE 1456 Query: 604 LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRA-QEALDAVSTLEEGHAQYLTSL 662 + E+ L+ ++ + R S+ + + A +EALD + T++ + + Sbjct: 1457 WKTKCEESQAELEASLKES------RSLSTELFKLKNAYEEALDQLETVKRENKNLEQEI 1510 Query: 663 ADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQ 722 AD + +A G T H + + + I+ + ALE + + Sbjct: 1511 ADLTEQIA--------------ENGKTIH--ELEKSRKQIELEKADIQLALE-----EAE 1549 Query: 723 QALRHMQASLVRTPL---QGILQLGQELKPKSLDVRQ---------EELGAVVDKEMAAT 770 AL H +A ++R L Q ++ +++ K ++ Q E + + +D E+ + Sbjct: 1550 AALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSR 1609 Query: 771 SAAI------EDAVRRIEDMMNQA-RHASSGVK-------------LEVNERILNSCTDL 810 + AI E + IE ++ A R A+ +K L +++ L DL Sbjct: 1610 NEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDA-LRGQEDL 1668 Query: 811 MKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAA 870 + + ++ + LQ E VE R Q E K + + L+ +++ V QL+ Sbjct: 1669 KEQLAIVERRANLLQAE-VEELRATLEQTERARKLAE--QELLDSNERV-----QLLHTQ 1720 Query: 871 DKVVLHTGKYEE--LIVCSHEIA-ASTAQLVAASKVK-----ANKHSPHLSRLQECSRTV 922 + ++HT K E L+ E+ AS A K K A + L + Q+ S + Sbjct: 1721 NTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1780 Query: 923 NERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMR 980 N+ + K Q ++++ + + G KKQ + + R+ ELE LE E+ + Sbjct: 1781 ERMKKNLEQTVKDLQHRLDEAEQLALKGG-----KKQIQKLETRIRELEFELEGEQKK 1833 Score = 60.5 bits (145), Expect = 8e-09 Identities = 80/291 (27%), Positives = 134/291 (46%), Gaps = 43/291 (14%) Query: 328 VKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALV 387 V++ DLQ++ +++E E + L+A+ QL LE +++E ++ + Sbjct: 882 VQEKNDLQLQ--------VQAESENL-LDAEERCDQLIKAKFQLEAKIKEVTERAE---- 928 Query: 388 DNEQLRHELAQLRAAQLEGERSQGLRE---------EAERKASATEARYNKLKEKHSELV 438 D E++ EL + +LE E S+ ++ + E++ ATE + L E+ S L Sbjct: 929 DEEEINAELTA-KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLD 987 Query: 439 HVHAELLR--KNADTAKQLTVTQQSQEE-----VARVKEQLAFQVEQVKRESELKLEEKS 491 A+L R K A Q + EE + + K +L QVE + ES L+ E+K Sbjct: 988 ETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDL--ESSLEQEKKL 1045 Query: 492 D-QLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADL 550 LE+ KR+LE G+L AQE++ E K +L RL E L V + Sbjct: 1046 RVDLERNKRKLE---GDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLG 1102 Query: 551 LAAQSLVRETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRL 596 L Q ++E +A + E +R+++ + E Q RE +E L +RL Sbjct: 1103 LQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEE--LSERL 1151 Score = 54.7 bits (130), Expect = 5e-07 Identities = 116/545 (21%), Positives = 224/545 (41%), Gaps = 96/545 (17%) Query: 399 LRAAQLEGERSQGLREEAER---KASATEARYNKLKEKHSELVHVHAELLRKNADTAKQL 455 L++A+ E E + ++EE ++ + + +EA+ +L+EK LV +L + ++ L Sbjct: 841 LKSAETEKEMAT-MKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENL 899 Query: 456 TVTQQSQEEVARVKEQLAFQVEQVKRESE-------------LKLEEKSDQLEKLKRELE 502 ++ +++ + K QL ++++V +E KLE++ +L+K +LE Sbjct: 900 LDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 959 Query: 503 AKAGELARAQEALSHTEQSKSELSSRLD----TLSAEKDALSGAVRQREADLLAAQSLVR 558 ++ + + A + ++ +E S LD L+ EK AL A +Q DL A + V Sbjct: 960 LTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVN 1019 Query: 559 ETEAALSREQQR-----SSQEQ----------------GEL---QGRLAERESQEQGLRQ 594 S+ +Q+ SS EQ G+L Q + + E+ +Q L + Sbjct: 1020 SLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDE 1079 Query: 595 RLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEG 654 RL + F + LQ V + L L+ L +R +E + + Sbjct: 1080 RLKKKDFEYCQ---------LQSKVED-EQTLGLQFQKKIKELQARIEELEEEIEAERAT 1129 Query: 655 HAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALE 714 A+ +D + + L+ A GG TS I+ ++ A L+ Sbjct: 1130 RAKTEKQRSDYARELEELSERLEEA------GGVTS---------TQIELNKKREAEFLK 1174 Query: 715 LMGQLQDQQALRH--MQASLVRTPLQGILQLGQELK-----PKSLDVRQEELGAVVD--- 764 L L ++ L+H M A+L + + +LG+++ + L+ + E +D Sbjct: 1175 LRRDL-EEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLS 1233 Query: 765 ---KEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTS 821 + ++ + A +E R +ED +++AR NE I S ++L L T + Sbjct: 1234 SSMESVSKSKANLEKICRTLEDQLSEARGK--------NEEIQRSLSELTTQKSRLQTEA 1285 Query: 822 TSLQKEIVES----GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHT 877 L +++ E + + ++Q F + L +KA A L + L Sbjct: 1286 GELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLR 1345 Query: 878 GKYEE 882 +YEE Sbjct: 1346 EQYEE 1350 Score = 53.1 bits (126), Expect = 1e-06 Identities = 129/689 (18%), Positives = 264/689 (38%), Gaps = 65/689 (9%) Query: 335 QIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 394 ++ + E + +EL K + + ++LK ++ LE L + K+K + L Sbjct: 922 EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTE 981 Query: 395 ELAQLRAAQLEGERSQGLREEAERKA----SATEARYNKLKEKHSELVH----------- 439 EL+ L + R + +EA ++A A E + N L + S+L Sbjct: 982 ELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQ 1041 Query: 440 ---VHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVE---------QVKRESEL-- 485 + +L R L + Q+S ++ K+QL +++ Q K E E Sbjct: 1042 EKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTL 1101 Query: 486 ------KLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL 539 K++E ++E+L+ E+EA+ A+ ++ S + ELS RL+ Sbjct: 1102 GLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQ 1161 Query: 540 SGAVRQREADLLAAQSLVRETEAALSREQQRSS--QEQGELQGRLAERESQEQGLRQRLL 597 ++REA+ L + + EA L E ++ ++ + L E+ Q ++Q+L Sbjct: 1162 IELNKKREAEFLKLRRDLE--EATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLE 1219 Query: 598 DEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQ 657 E+ + ++VSK L C + D L + + +L E Q Sbjct: 1220 KEKSEF--KLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQ 1277 Query: 658 YLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMG 717 +A L L ++I++ + S A T + L E L Sbjct: 1278 KSRLQTEAGELSRQLEE-----KESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAH 1332 Query: 718 QLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVD--KEMAATSAAIE 775 LQ + + +G +L + L + +V Q D + A + Sbjct: 1333 ALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK 1392 Query: 776 DAVRRIEDMMNQ--ARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGR 833 +R++D Q A +A + +R+ DLM + + + +L K+ + Sbjct: 1393 KLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDK 1452 Query: 834 GAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVV--LHTGKYEELIVCSHEIA 891 A + ++ E + S+++ +L A ++ + L T K E + EIA Sbjct: 1453 VLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNL-EQEIA 1511 Query: 892 ASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGL 951 T Q+ K + L++ + + A++ + + + +E + + + Sbjct: 1512 DLTEQIAENGKT--------IHELEKSRKQIELEKADIQLALEEAEAALEHEE----AKI 1559 Query: 952 SLIKLKKQEMETQVRVLELEKTLEAERMR 980 I+L+ ++++++ EK E E+++ Sbjct: 1560 LRIQLELTQVKSEIDRKIAEKDEEIEQLK 1588 Score = 40.4 bits (93), Expect = 0.009 Identities = 43/198 (21%), Positives = 91/198 (45%), Gaps = 18/198 (9%) Query: 335 QIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 394 ++E R+ + +K +A +LK + + LE +K ++ + D L+H Sbjct: 1741 EVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDT-SAHLERMKKNLEQTVKD---LQH 1796 Query: 395 ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 454 L + L+G + Q ++ E + E ++K++E V + LRK K+ Sbjct: 1797 RLDEAEQLALKGGKKQ--IQKLETRIRELEFELEGEQKKNTESV----KGLRKYERRVKE 1850 Query: 455 LTV-TQQSQEEVARVK---EQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELAR 510 LT +++ ++ V R++ ++L +V+ KR++E E+ + L K ++ EL Sbjct: 1851 LTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQH----ELEE 1906 Query: 511 AQEALSHTEQSKSELSSR 528 A+E E ++L ++ Sbjct: 1907 AEERADIAESQVNKLRAK 1924 Score = 31.6 bits (70), Expect = 4.1 Identities = 17/51 (33%), Positives = 28/51 (54%), Gaps = 6/51 (11%) Query: 937 QEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQ 987 Q ++ED T+ ++ +K+ E Q R+ ELE+ +EAER + KQ Sbjct: 1092 QSKVEDEQTLG------LQFQKKIKELQARIEELEEEIEAERATRAKTEKQ 1136 >gi|41322923 plectin 1 isoform 11 [Homo sapiens] Length = 4547 Score = 79.0 bits (193), Expect = 2e-14 Identities = 170/688 (24%), Positives = 284/688 (41%), Gaps = 102/688 (14%) Query: 334 LQIESLKR-------EVEMLRS---ELEKIKLEAQRYIAQLKSQV-----NALEGELE-- 376 LQ+E+ +R E++ LR+ E E K +AQ +L+ QV + E+E Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1518 Query: 377 -------EQRKQKQKALVDNEQLR--HELAQLRAAQLEGERSQGLREEAERKASATEARY 427 E ++KQ+AL E+LR E A+ R Q E ER++ ++ E + EA Sbjct: 1519 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-- 1576 Query: 428 NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 487 +L+ K + A+L R + + + V Q +E R ++Q + E+ + E+E +L Sbjct: 1577 -ELQSKRASFAEKTAQLERSLQE--EHVAVAQLREEAERRAQQQA--EAERAREEAEREL 1631 Query: 488 EE---KSDQLEKLKRELEAKAGELARAQ-EALSHTEQSKSELSSRLDTLSAEKDALSGAV 543 E K+++ +L+ + E A + + AQ EA E+++ E R A AV Sbjct: 1632 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAV 1684 Query: 544 RQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 603 RQRE LA Q L ++ + A QQR + EQ EL AE E EQ +++LL+E+ A Sbjct: 1685 RQRE---LAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQ--QRQLLEEELAR 1738 Query: 604 LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA 663 L+ AA A Q+ L+ L L S+A+ ++ ST E+ + Sbjct: 1739 LQREAAAATQKRQE----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR------ 1788 Query: 664 DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 723 L A RF LA + A A + A R E AR Q + Sbjct: 1789 ----LEAEAGRFRELAEE------AARLRALAEEAKRQRQLAEEDAAR--------QRAE 1830 Query: 724 ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR--- 780 A R + L L+ E+ K + E L + + E E A + Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1890 Query: 781 IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG-AATQQ 839 IE+ + Q R AS +LE + ++ D ++ R + +L+ ++ G A + Sbjct: 1891 IEERLAQLRKASDS-ELERQKGLVE---DTLRQRRQVEEEILALKASFEKAAAGKAELEL 1946 Query: 840 EFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEEL--IVCSHEIAASTAQL 897 E S + L S +A A Q AA++ E + + + E AA + Sbjct: 1947 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2006 Query: 898 VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLK 957 + RL+E R E A + + ++ Q++++ + K Sbjct: 2007 ALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEE------------K 2052 Query: 958 KQEMETQVRVLELEKTLEAERMRLGELR 985 Q + EL++TL+ E+ L +LR Sbjct: 2053 AHAFAVQQKEQELQQTLQQEQSVLDQLR 2080 Score = 77.8 bits (190), Expect = 5e-14 Identities = 158/768 (20%), Positives = 296/768 (38%), Gaps = 96/768 (12%) Query: 330 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 389 +D Q ++ E+ L++ EK A A+L+ ++ + E+ + K++A ++ Sbjct: 1914 EDTLRQRRQVEEEILALKASFEK----AAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1969 Query: 390 EQLRHELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 445 + R A+ + E E +S EEA R+ A +LK K E A L Sbjct: 1970 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRL 2024 Query: 446 RKNAD--TAKQLTVTQQSQEEVARVKEQL-AFQVEQVKRESELKLEEKSDQLEKLKRELE 502 R+ A+ +A+QL + Q++ ++ + +E+ AF V+Q ++E + L+++ L++L+ E E Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2084 Query: 503 AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 562 A A+EA E+ ++ +++ K + + R AA+ L +E E Sbjct: 2085 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144 Query: 563 ALSREQQRSSQEQGELQGRLAERESQ----EQGLRQR----------------------L 596 +R Q + Q AE E EQ LRQ+ L Sbjct: 2145 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2204 Query: 597 LDEQFAVLRGAAAEAAGILQDAVSKLD---------DPLHLRCTSSPDYLVSRAQEALDA 647 LDE+ L+ A EAA +L L R + L+ R ++ Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264 Query: 648 VSTLE-EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 706 E E Q A S R LA + + A + + + + R Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324 Query: 707 -ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELK--PKSLDV---RQEELG 760 + A L+ +L +QA R L Q QL +E + ++L+ RQ E+ Sbjct: 2325 LKAEAELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2379 Query: 761 AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 820 A ++ + R ED + A E+ E++ T+L ++ + Sbjct: 2380 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR--TELATQEKVTLVQ 2432 Query: 821 STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLH---- 876 + +Q++ +S A +E A+ R E L +K + + ++ + +L Sbjct: 2433 TLEIQRQ--QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490 Query: 877 -----TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVA 931 + + L+ I A+L + + K Q + + + +VA Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2550 Query: 932 STKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGE----LRKQ 987 S + + + + + G+ + + Q++E Q R + E+ L E RL E L +Q Sbjct: 2551 SMEEARRRQHEAE----EGVRRKQEELQQLEQQRR--QQEELLAEENQRLREQLQLLEEQ 2604 Query: 988 HYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLD 1035 H A+ + EEV A +++ + L P+ +H D Sbjct: 2605 H----RAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEPEHSFD 2647 Score = 73.9 bits (180), Expect = 7e-13 Identities = 151/697 (21%), Positives = 281/697 (40%), Gaps = 81/697 (11%) Query: 344 EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA-- 401 + L +E E I+L A+ Q + Q LE EL +++ A ++L ELA++RA Sbjct: 1707 QRLAAEQELIRLRAET--EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1764 Query: 402 -------AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 454 A+ E E S+ E+++++ A R+ +L E+ + L AE ++ A++ Sbjct: 1765 EVLLASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARL-RALAEEAKRQRQLAEE 1822 Query: 455 LTVTQQSQEEVARVKEQLAF-QVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQE 513 Q+++ E ++ A + ++K E+E+ L+EK + E+L+R E +A + R +E Sbjct: 1823 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1882 Query: 514 ALSHTEQSKSELSSRL--------DTLSAEKDALSGAVRQR---EADLLAAQSLVR---- 558 Q K+++ RL L +K + +RQR E ++LA ++ Sbjct: 1883 ---QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1939 Query: 559 ---ETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAE 610 E E L R E S+EQ EL+ + + E+ R+R +E+ A E Sbjct: 1940 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999 Query: 611 AAGILQDAV-------SKLDDPLHLRCTSSPDYL--VSRAQEALDAVSTLEEGHAQYLTS 661 AA + A+ +K+++ LR + + + AQEA A L+ + + Sbjct: 2000 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA--AQKRLQAEEKAHAFA 2057 Query: 662 LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECG-----ARALELM 716 + + + D + + A + + + RE E + Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2117 Query: 717 GQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIED 776 Q ++QA QA L+ +E + ++ Q E A+ K+ A A +E Sbjct: 2118 KQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQ--AADAEMEK 2169 Query: 777 AVRRIEDMMNQARHASS-----GVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 831 + E + Q ++LE + N + ++ ++ T + + ++ E Sbjct: 2170 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2229 Query: 832 GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQ--LVEAADKVVLHTGKYEELIVCSHE 889 Q E +K E A TQ L E A+K+ + L V + E Sbjct: 2230 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2289 Query: 890 IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 949 AA QL A + A + + L+E + V E K+ E ++ + + Sbjct: 2290 -AARLRQL--AEEDLAQQRALAEKMLKEKMQAVQE-----ATRLKAEAELLQQQKELAQE 2341 Query: 950 GLSLIKLKKQEMETQV--RVLELEKTLEAERMRLGEL 984 ++ K++M Q+ ++TLEAER R E+ Sbjct: 2342 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2378 Score = 68.6 bits (166), Expect = 3e-11 Identities = 153/722 (21%), Positives = 289/722 (40%), Gaps = 104/722 (14%) Query: 336 IESLKREVEMLRSELEKIKLEAQRYI-AQLKSQVNALEGELEEQRK-------QKQKALV 387 +E L+ + E L + ++E R + L++ + E EL+ +R Q +++L Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1597 Query: 388 DNE----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 443 + QLR E + Q E ER+ REEAER+ + + N+ + V + Sbjct: 1598 EEHVAVAQLREEAERRAQQQAEAERA---REEAERELERWQLKANEALRLRLQAEEVAQQ 1654 Query: 444 LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE------------------- 484 A+ KQ ++ + +EQ Q E ++E E Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714 Query: 485 -LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL--SG 541 ++L +++Q E+ ++ LE ELAR Q + Q + EL + L + AE + L S Sbjct: 1715 LIRLRAETEQGEQQRQLLEE---ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1771 Query: 542 AVRQREADLLAAQSLVR-ETEAALSRE------QQRSSQEQGELQGRLAERESQEQGLR- 593 A + E+ + +S R E EA RE + R+ E+ + Q +LAE ++ Q Sbjct: 1772 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831 Query: 594 QRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEE 653 +R+L E+ A A EA + +A L + + + L A++ LEE Sbjct: 1832 ERVLAEKLA----AIGEATRLKTEAEIALKEK-----EAENERLRRLAEDEAFQRRRLEE 1882 Query: 654 GHAQYLTSLADASALV-----AALTRFSHLAADTIINGGATSH--LAPTDPADRLIDTCR 706 AQ+ + + A + + L R L DT+ LA ++ Sbjct: 1883 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK-----A 1937 Query: 707 ECGARALEL-MGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV 763 G LEL +G+++ + LR + + + Q L +E + + + R ++ A Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1997 Query: 764 DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT--- 820 ++ AA+E+ V R++ + +AR + E ++ + K ++ Sbjct: 1998 EEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2056 Query: 821 ---------STSLQKE--IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEA 869 +LQ+E +++ RG A A+ + E + A + Q+ EA Sbjct: 2057 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE--EARVQAEREAAQSRRQVEEA 2114 Query: 870 ADKVVLHTGKYEELIVCSHEIAASTAQLVAAS---KVKANKHSPHLSRLQECSRTVNERA 926 E L + E A + AQ AA+ + +A + + ++ ++ + + A Sbjct: 2115 -----------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2163 Query: 927 ANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGELR 985 + K EQ + L+ ++L+ +E + Q +L+ E + L+AE R Sbjct: 2164 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2223 Query: 986 KQ 987 Q Sbjct: 2224 SQ 2225 Score = 66.2 bits (160), Expect = 1e-10 Identities = 90/330 (27%), Positives = 146/330 (44%), Gaps = 63/330 (19%) Query: 335 QIESLKREVEMLRSE----LEKIK--LEAQRYIAQLKSQVNA--------LEGELEEQRK 380 ++E +R E R+E L +++ LE QR +A+ +Q A L+ ++E+ Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402 Query: 381 QKQKALVDNEQ----LRHELAQLRA---AQLEGERSQGLREEAERKASATEARYNKLKEK 433 ++++A VD +Q ++ EL QLR A+++ + Q E R E R +L+ + Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462 Query: 434 HSELVHVHAE----LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEE 489 +E AE LR A+ A+ +Q+QEE R++ Q V+ ES+ K + Sbjct: 1463 ATERQRGGAEGELQALRARAEEAE--AQKRQAQEEAERLRRQ-------VQDESQRKRQA 1513 Query: 490 KSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKD-----ALSGAVR 544 + + ++K E EA A E RA +AL E RL E+ AL A R Sbjct: 1514 EVELASRVKAEAEA-AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1572 Query: 545 QREADLLAAQSLVRETEAALSR--------------EQQRSSQEQGELQGRLAERESQ-- 588 EA+L + ++ E A L R E +R +Q+Q E + E E + Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632 Query: 589 ------EQGLRQRLLDEQFAVLRG-AAAEA 611 + LR RL E+ A + A AEA Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEA 1662 Score = 65.9 bits (159), Expect = 2e-10 Identities = 151/729 (20%), Positives = 289/729 (39%), Gaps = 107/729 (14%) Query: 330 DDRDLQIESLKREVEMLRSELEKIKL---EAQRYIAQLKSQVNALEGELEEQRKQKQKAL 386 D R ++E L R++ R + + +A+R Q+++ A + EQ +Q+Q L Sbjct: 1196 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1255 Query: 387 VDNEQLRHELAQLRA--------------------AQLEGERSQGLREEAERKASATEAR 426 + E+ ++ + + AQLE S + + + + + Sbjct: 1256 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1315 Query: 427 YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ-SQEEVARVKEQLA---FQVEQVKRE 482 Y L+ +SEL + ++ ++ ++T +++ ++ ++++ A +E+LA +E+ ++ Sbjct: 1316 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1375 Query: 483 SELKLEEKSDQLEKLKRELEAK-AGELARAQEALSHTEQSKSELSSRLDTLSAEKDA-LS 540 +E + K+ Q E+ +EL+ + E+ R +EA +Q K + L L +A + Sbjct: 1376 AEAHAQAKA-QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1434 Query: 541 GAVRQREA---DLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA-------------- 583 RQ EA L + +R L +++ +GELQ A Sbjct: 1435 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1494 Query: 584 -----ERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL- 637 R+ Q++ R+R + + A A AEAA Q A+ L++ L L+ + L Sbjct: 1495 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-LRLQAEEAERRLR 1553 Query: 638 ---VSRAQEALDAVSTLEEGHAQYL----TSLADASALVAALTRFSHLAADTIINGGATS 690 V RA++ A+ T + L S A+ +A + + H+A + A Sbjct: 1554 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV-AQLREEAER 1612 Query: 691 HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPK 750 A+R RE R LE QL+ +ALR LQ + + K Sbjct: 1613 RAQQQAEAER----AREEAERELE-RWQLKANEALRLR------------LQAEEVAQQK 1655 Query: 751 SL-DVRQEELGAVVDKEMAATSAAIEDAVRRIE------DMMNQARHASSGVKLEVNERI 803 SL E+ ++E A E AVR+ E + Q ++ +L + + Sbjct: 1656 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1715 Query: 804 LNSCTDLMKA---IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLI-SASKAV 859 + + + +LL LQ+E + + + AK E L+ S ++A Sbjct: 1716 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1775 Query: 860 GWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECS 919 + ++ ++ G++ EL + E A A A + + + E Sbjct: 1776 EESRSTSEKSKQRLEAEAGRFREL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1832 Query: 920 RTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM 979 R + E+ A + +T+ E + I LK++E E + R+ L + +R Sbjct: 1833 RVLAEKLAAIGEATRLKTE-------------AEIALKEKEAENE-RLRRLAEDEAFQRR 1878 Query: 980 RLGELRKQH 988 RL E QH Sbjct: 1879 RLEEQAAQH 1887 Score = 62.4 bits (150), Expect = 2e-09 Identities = 94/410 (22%), Positives = 167/410 (40%), Gaps = 41/410 (10%) Query: 332 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 391 R L E L ++ L ++ K K++A + +LK++ L+ + E ++Q ++ D EQ Sbjct: 2294 RQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352 Query: 392 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE----LLRK 447 + +LA + +G + E + + EA KL+ AE RK Sbjct: 2353 MAQQLA----EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408 Query: 448 NA-DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKREL--EAK 504 A + ++L T+ + +E + + L Q +Q ++E +L E +LE+ K +L EAK Sbjct: 2409 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAK 2467 Query: 505 AGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA-- 562 +L + EQ E + + +EKD+L R E + + L ++ A Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2527 Query: 563 -ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSK 621 L EQQR Q+ + + RL S E+ R+ + A E Q+ + + Sbjct: 2528 QQLREEQQRQQQQMEQERQRLV--ASMEEARRR----------QHEAEEGVRRKQEELQQ 2575 Query: 622 LDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAAD 681 L+ + + L Q + + LEE H L + +A A T+ Sbjct: 2576 LEQ----QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK------- 2624 Query: 682 TIING--GATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQ 729 T+ NG A +P R+ A+ L+ G L ++ R Q Sbjct: 2625 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2674 Score = 49.3 bits (116), Expect = 2e-05 Identities = 151/706 (21%), Positives = 265/706 (37%), Gaps = 78/706 (11%) Query: 334 LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 393 L I + E+LR+ E++K EAQ A L ++ A + L++ R Q + + LR Sbjct: 1093 LVIRGTQGAEEVLRAHEEQLK-EAQAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALR 1150 Query: 394 HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 453 EL R AQ GER Q E + + R +L E+ ++ R+ + Sbjct: 1151 DEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1207 Query: 454 QLTVTQQSQEEVARVKEQLAFQVEQVKR---ESELKLEEKSDQLEKLKRELEAKAGELAR 510 QL ++S + + + + EQ++ + E+ Q + L E+E ++ Sbjct: 1208 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1267 Query: 511 AQEALSHTEQSKSELSSRLDTLSAEKDAL------------SGAVRQREADL-------- 550 Q + + +L T A+ + + S +V Q DL Sbjct: 1268 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1327 Query: 551 -LAAQ--SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA 607 L +Q + ET + E++ + Q++ E + RLAE E+ + +QR L E A + Sbjct: 1328 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE--KQRQLAEAHAQAKAQ 1385 Query: 608 AAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA 667 A A LQ ++ + + R ++ D + + + A+ A A Sbjct: 1386 AEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442 Query: 668 LVAALTRFS--------HLAADTIINGGATSHL-APTDPADRLIDTCRECGARALELMGQ 718 + R L A GGA L A A+ R+ A L Q Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502 Query: 719 LQDQQALRHMQ----ASLVRTPL------QGILQLGQELKPKSLDVRQEELGAVVDKEMA 768 +QD+ + AS V+ Q LQ +EL+ ++ + + A V++ Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER-AR 1561 Query: 769 ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 828 A+E A R E + Q++ AS K ER L + +R Q E Sbjct: 1562 QVQVALETAQRSAEAEL-QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1620 Query: 829 VESGRGAATQQEFY------AKNSRWTEGLISASKAVGWG-ATQLVEAADKVVLHTGKYE 881 + A + E + A R ++ K++ A + E A++ GK E Sbjct: 1621 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1680 Query: 882 ELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ-- 939 E V E+A +L ++ L+ QE R + A T+ G++Q Sbjct: 1681 EQAVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIR--------LRAETEQGEQQRQ 1730 Query: 940 -IEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGE 983 +E+ + K+QE+E ++ + E + L A + R E Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776 Score = 45.1 bits (105), Expect = 4e-04 Identities = 136/688 (19%), Positives = 264/688 (38%), Gaps = 67/688 (9%) Query: 337 ESLKREVEMLRS----ELEKIKLEAQR---YIAQLKSQVNALEGELEEQRKQKQKALVDN 389 +SL+R+V+++RS +K E QR + +L Q + + + + + + Sbjct: 897 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 956 Query: 390 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 449 E + QL QG +EE+ + +E + +L+ + E VH L + Sbjct: 957 E---YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1013 Query: 450 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--LKLEEKSDQLEKLKRELEAKAGE 507 + A++ Q++ E L V ++ E+E L L E S L+ ELE G+ Sbjct: 1014 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1073 Query: 508 LARAQE--------------ALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA 553 L + + + T+ ++ L + + L E A+ + + EA + Sbjct: 1074 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASL 1132 Query: 554 QSLVRETEAA-----LSREQQRSSQEQGE-LQGRLAERESQEQGLRQR---LLDEQFAVL 604 + L + EA R++ R +QE GE LQ R ER+ + + R+R LL+ AVL Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1192 Query: 605 -----RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYL 659 R E G + DPL + R QE + A+ + + Sbjct: 1193 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA-----RRRQEQIQAMPLADSQAVR-- 1245 Query: 660 TSLADASALVAALTRFSHLA------ADTIINGGATSHLAPTDPADRLIDTCRECGARAL 713 L AL+ + R A IN L +L + Sbjct: 1246 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1305 Query: 714 ELMGQ--LQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 771 + + +Q+ LR + L Q I + + L+ + R E ++E A Sbjct: 1306 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1365 Query: 772 AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 831 A + R++ + QA+ + E+ +R+ +A S+Q+E+ + Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425 Query: 832 GRGAATQQEFYAKNSRWTE-GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEI 890 + + + + A+ + E + + + QL EA ++ G EL + Sbjct: 1426 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATER--QRGGAEGEL-----QA 1477 Query: 891 AASTAQLVAASKVKANKHSPHLSR-LQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 949 + A+ A K +A + + L R +Q+ S+ + + + K+ E ++ Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-LQ 1536 Query: 950 GLSLIKLKKQEMETQVRVLELEKTLEAE 977 L ++L+ +E E ++R E+E+ + + Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQ 1564 >gi|41322914 plectin 1 isoform 10 [Homo sapiens] Length = 4551 Score = 79.0 bits (193), Expect = 2e-14 Identities = 170/688 (24%), Positives = 284/688 (41%), Gaps = 102/688 (14%) Query: 334 LQIESLKR-------EVEMLRS---ELEKIKLEAQRYIAQLKSQV-----NALEGELE-- 376 LQ+E+ +R E++ LR+ E E K +AQ +L+ QV + E+E Sbjct: 1463 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1522 Query: 377 -------EQRKQKQKALVDNEQLR--HELAQLRAAQLEGERSQGLREEAERKASATEARY 427 E ++KQ+AL E+LR E A+ R Q E ER++ ++ E + EA Sbjct: 1523 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-- 1580 Query: 428 NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 487 +L+ K + A+L R + + + V Q +E R ++Q + E+ + E+E +L Sbjct: 1581 -ELQSKRASFAEKTAQLERSLQE--EHVAVAQLREEAERRAQQQA--EAERAREEAEREL 1635 Query: 488 EE---KSDQLEKLKRELEAKAGELARAQ-EALSHTEQSKSELSSRLDTLSAEKDALSGAV 543 E K+++ +L+ + E A + + AQ EA E+++ E R A AV Sbjct: 1636 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAV 1688 Query: 544 RQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 603 RQRE LA Q L ++ + A QQR + EQ EL AE E EQ +++LL+E+ A Sbjct: 1689 RQRE---LAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQ--QRQLLEEELAR 1742 Query: 604 LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA 663 L+ AA A Q+ L+ L L S+A+ ++ ST E+ + Sbjct: 1743 LQREAAAATQKRQE----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR------ 1792 Query: 664 DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 723 L A RF LA + A A + A R E AR Q + Sbjct: 1793 ----LEAEAGRFRELAEE------AARLRALAEEAKRQRQLAEEDAAR--------QRAE 1834 Query: 724 ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR--- 780 A R + L L+ E+ K + E L + + E E A + Sbjct: 1835 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1894 Query: 781 IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG-AATQQ 839 IE+ + Q R AS +LE + ++ D ++ R + +L+ ++ G A + Sbjct: 1895 IEERLAQLRKASDS-ELERQKGLVE---DTLRQRRQVEEEILALKASFEKAAAGKAELEL 1950 Query: 840 EFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEEL--IVCSHEIAASTAQL 897 E S + L S +A A Q AA++ E + + + E AA + Sbjct: 1951 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2010 Query: 898 VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLK 957 + RL+E R E A + + ++ Q++++ + K Sbjct: 2011 ALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEE------------K 2056 Query: 958 KQEMETQVRVLELEKTLEAERMRLGELR 985 Q + EL++TL+ E+ L +LR Sbjct: 2057 AHAFAVQQKEQELQQTLQQEQSVLDQLR 2084 Score = 77.8 bits (190), Expect = 5e-14 Identities = 158/768 (20%), Positives = 296/768 (38%), Gaps = 96/768 (12%) Query: 330 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 389 +D Q ++ E+ L++ EK A A+L+ ++ + E+ + K++A ++ Sbjct: 1918 EDTLRQRRQVEEEILALKASFEK----AAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1973 Query: 390 EQLRHELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 445 + R A+ + E E +S EEA R+ A +LK K E A L Sbjct: 1974 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRL 2028 Query: 446 RKNAD--TAKQLTVTQQSQEEVARVKEQL-AFQVEQVKRESELKLEEKSDQLEKLKRELE 502 R+ A+ +A+QL + Q++ ++ + +E+ AF V+Q ++E + L+++ L++L+ E E Sbjct: 2029 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2088 Query: 503 AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 562 A A+EA E+ ++ +++ K + + R AA+ L +E E Sbjct: 2089 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2148 Query: 563 ALSREQQRSSQEQGELQGRLAERESQ----EQGLRQR----------------------L 596 +R Q + Q AE E EQ LRQ+ L Sbjct: 2149 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2208 Query: 597 LDEQFAVLRGAAAEAAGILQDAVSKLD---------DPLHLRCTSSPDYLVSRAQEALDA 647 LDE+ L+ A EAA +L L R + L+ R ++ Sbjct: 2209 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2268 Query: 648 VSTLE-EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 706 E E Q A S R LA + + A + + + + R Sbjct: 2269 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2328 Query: 707 -ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELK--PKSLDV---RQEELG 760 + A L+ +L +QA R L Q QL +E + ++L+ RQ E+ Sbjct: 2329 LKAEAELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2383 Query: 761 AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 820 A ++ + R ED + A E+ E++ T+L ++ + Sbjct: 2384 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR--TELATQEKVTLVQ 2436 Query: 821 STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLH---- 876 + +Q++ +S A +E A+ R E L +K + + ++ + +L Sbjct: 2437 TLEIQRQ--QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2494 Query: 877 -----TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVA 931 + + L+ I A+L + + K Q + + + +VA Sbjct: 2495 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2554 Query: 932 STKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGE----LRKQ 987 S + + + + + G+ + + Q++E Q R + E+ L E RL E L +Q Sbjct: 2555 SMEEARRRQHEAE----EGVRRKQEELQQLEQQRR--QQEELLAEENQRLREQLQLLEEQ 2608 Query: 988 HYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLD 1035 H A+ + EEV A +++ + L P+ +H D Sbjct: 2609 H----RAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEPEHSFD 2651 Score = 73.9 bits (180), Expect = 7e-13 Identities = 151/697 (21%), Positives = 281/697 (40%), Gaps = 81/697 (11%) Query: 344 EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA-- 401 + L +E E I+L A+ Q + Q LE EL +++ A ++L ELA++RA Sbjct: 1711 QRLAAEQELIRLRAET--EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1768 Query: 402 -------AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 454 A+ E E S+ E+++++ A R+ +L E+ + L AE ++ A++ Sbjct: 1769 EVLLASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARL-RALAEEAKRQRQLAEE 1826 Query: 455 LTVTQQSQEEVARVKEQLAF-QVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQE 513 Q+++ E ++ A + ++K E+E+ L+EK + E+L+R E +A + R +E Sbjct: 1827 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1886 Query: 514 ALSHTEQSKSELSSRL--------DTLSAEKDALSGAVRQR---EADLLAAQSLVR---- 558 Q K+++ RL L +K + +RQR E ++LA ++ Sbjct: 1887 ---QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1943 Query: 559 ---ETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAE 610 E E L R E S+EQ EL+ + + E+ R+R +E+ A E Sbjct: 1944 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2003 Query: 611 AAGILQDAV-------SKLDDPLHLRCTSSPDYL--VSRAQEALDAVSTLEEGHAQYLTS 661 AA + A+ +K+++ LR + + + AQEA A L+ + + Sbjct: 2004 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA--AQKRLQAEEKAHAFA 2061 Query: 662 LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECG-----ARALELM 716 + + + D + + A + + + RE E + Sbjct: 2062 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2121 Query: 717 GQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIED 776 Q ++QA QA L+ +E + ++ Q E A+ K+ A A +E Sbjct: 2122 KQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQ--AADAEMEK 2173 Query: 777 AVRRIEDMMNQARHASS-----GVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 831 + E + Q ++LE + N + ++ ++ T + + ++ E Sbjct: 2174 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2233 Query: 832 GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQ--LVEAADKVVLHTGKYEELIVCSHE 889 Q E +K E A TQ L E A+K+ + L V + E Sbjct: 2234 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2293 Query: 890 IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 949 AA QL A + A + + L+E + V E K+ E ++ + + Sbjct: 2294 -AARLRQL--AEEDLAQQRALAEKMLKEKMQAVQE-----ATRLKAEAELLQQQKELAQE 2345 Query: 950 GLSLIKLKKQEMETQV--RVLELEKTLEAERMRLGEL 984 ++ K++M Q+ ++TLEAER R E+ Sbjct: 2346 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2382 Score = 68.6 bits (166), Expect = 3e-11 Identities = 153/722 (21%), Positives = 289/722 (40%), Gaps = 104/722 (14%) Query: 336 IESLKREVEMLRSELEKIKLEAQRYI-AQLKSQVNALEGELEEQRK-------QKQKALV 387 +E L+ + E L + ++E R + L++ + E EL+ +R Q +++L Sbjct: 1542 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1601 Query: 388 DNE----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 443 + QLR E + Q E ER+ REEAER+ + + N+ + V + Sbjct: 1602 EEHVAVAQLREEAERRAQQQAEAERA---REEAERELERWQLKANEALRLRLQAEEVAQQ 1658 Query: 444 LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE------------------- 484 A+ KQ ++ + +EQ Q E ++E E Sbjct: 1659 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1718 Query: 485 -LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL--SG 541 ++L +++Q E+ ++ LE ELAR Q + Q + EL + L + AE + L S Sbjct: 1719 LIRLRAETEQGEQQRQLLEE---ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1775 Query: 542 AVRQREADLLAAQSLVR-ETEAALSRE------QQRSSQEQGELQGRLAERESQEQGLR- 593 A + E+ + +S R E EA RE + R+ E+ + Q +LAE ++ Q Sbjct: 1776 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1835 Query: 594 QRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEE 653 +R+L E+ A A EA + +A L + + + L A++ LEE Sbjct: 1836 ERVLAEKLA----AIGEATRLKTEAEIALKEK-----EAENERLRRLAEDEAFQRRRLEE 1886 Query: 654 GHAQYLTSLADASALV-----AALTRFSHLAADTIINGGATSH--LAPTDPADRLIDTCR 706 AQ+ + + A + + L R L DT+ LA ++ Sbjct: 1887 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK-----A 1941 Query: 707 ECGARALEL-MGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV 763 G LEL +G+++ + LR + + + Q L +E + + + R ++ A Sbjct: 1942 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2001 Query: 764 DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT--- 820 ++ AA+E+ V R++ + +AR + E ++ + K ++ Sbjct: 2002 EEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2060 Query: 821 ---------STSLQKE--IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEA 869 +LQ+E +++ RG A A+ + E + A + Q+ EA Sbjct: 2061 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE--EARVQAEREAAQSRRQVEEA 2118 Query: 870 ADKVVLHTGKYEELIVCSHEIAASTAQLVAAS---KVKANKHSPHLSRLQECSRTVNERA 926 E L + E A + AQ AA+ + +A + + ++ ++ + + A Sbjct: 2119 -----------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2167 Query: 927 ANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGELR 985 + K EQ + L+ ++L+ +E + Q +L+ E + L+AE R Sbjct: 2168 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2227 Query: 986 KQ 987 Q Sbjct: 2228 SQ 2229 Score = 66.2 bits (160), Expect = 1e-10 Identities = 90/330 (27%), Positives = 146/330 (44%), Gaps = 63/330 (19%) Query: 335 QIESLKREVEMLRSE----LEKIK--LEAQRYIAQLKSQVNA--------LEGELEEQRK 380 ++E +R E R+E L +++ LE QR +A+ +Q A L+ ++E+ Sbjct: 1347 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1406 Query: 381 QKQKALVDNEQ----LRHELAQLRA---AQLEGERSQGLREEAERKASATEARYNKLKEK 433 ++++A VD +Q ++ EL QLR A+++ + Q E R E R +L+ + Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1466 Query: 434 HSELVHVHAE----LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEE 489 +E AE LR A+ A+ +Q+QEE R++ Q V+ ES+ K + Sbjct: 1467 ATERQRGGAEGELQALRARAEEAE--AQKRQAQEEAERLRRQ-------VQDESQRKRQA 1517 Query: 490 KSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKD-----ALSGAVR 544 + + ++K E EA A E RA +AL E RL E+ AL A R Sbjct: 1518 EVELASRVKAEAEA-AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1576 Query: 545 QREADLLAAQSLVRETEAALSR--------------EQQRSSQEQGELQGRLAERESQ-- 588 EA+L + ++ E A L R E +R +Q+Q E + E E + Sbjct: 1577 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1636 Query: 589 ------EQGLRQRLLDEQFAVLRG-AAAEA 611 + LR RL E+ A + A AEA Sbjct: 1637 RWQLKANEALRLRLQAEEVAQQKSLAQAEA 1666 Score = 65.9 bits (159), Expect = 2e-10 Identities = 151/729 (20%), Positives = 289/729 (39%), Gaps = 107/729 (14%) Query: 330 DDRDLQIESLKREVEMLRSELEKIKL---EAQRYIAQLKSQVNALEGELEEQRKQKQKAL 386 D R ++E L R++ R + + +A+R Q+++ A + EQ +Q+Q L Sbjct: 1200 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1259 Query: 387 VDNEQLRHELAQLRA--------------------AQLEGERSQGLREEAERKASATEAR 426 + E+ ++ + + AQLE S + + + + + Sbjct: 1260 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1319 Query: 427 YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ-SQEEVARVKEQLA---FQVEQVKRE 482 Y L+ +SEL + ++ ++ ++T +++ ++ ++++ A +E+LA +E+ ++ Sbjct: 1320 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1379 Query: 483 SELKLEEKSDQLEKLKRELEAK-AGELARAQEALSHTEQSKSELSSRLDTLSAEKDA-LS 540 +E + K+ Q E+ +EL+ + E+ R +EA +Q K + L L +A + Sbjct: 1380 AEAHAQAKA-QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1438 Query: 541 GAVRQREA---DLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA-------------- 583 RQ EA L + +R L +++ +GELQ A Sbjct: 1439 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1498 Query: 584 -----ERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL- 637 R+ Q++ R+R + + A A AEAA Q A+ L++ L L+ + L Sbjct: 1499 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-LRLQAEEAERRLR 1557 Query: 638 ---VSRAQEALDAVSTLEEGHAQYL----TSLADASALVAALTRFSHLAADTIINGGATS 690 V RA++ A+ T + L S A+ +A + + H+A + A Sbjct: 1558 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV-AQLREEAER 1616 Query: 691 HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPK 750 A+R RE R LE QL+ +ALR LQ + + K Sbjct: 1617 RAQQQAEAER----AREEAERELE-RWQLKANEALRLR------------LQAEEVAQQK 1659 Query: 751 SL-DVRQEELGAVVDKEMAATSAAIEDAVRRIE------DMMNQARHASSGVKLEVNERI 803 SL E+ ++E A E AVR+ E + Q ++ +L + + Sbjct: 1660 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1719 Query: 804 LNSCTDLMKA---IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLI-SASKAV 859 + + + +LL LQ+E + + + AK E L+ S ++A Sbjct: 1720 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1779 Query: 860 GWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECS 919 + ++ ++ G++ EL + E A A A + + + E Sbjct: 1780 EESRSTSEKSKQRLEAEAGRFREL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1836 Query: 920 RTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM 979 R + E+ A + +T+ E + I LK++E E + R+ L + +R Sbjct: 1837 RVLAEKLAAIGEATRLKTE-------------AEIALKEKEAENE-RLRRLAEDEAFQRR 1882 Query: 980 RLGELRKQH 988 RL E QH Sbjct: 1883 RLEEQAAQH 1891 Score = 62.4 bits (150), Expect = 2e-09 Identities = 94/410 (22%), Positives = 167/410 (40%), Gaps = 41/410 (10%) Query: 332 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 391 R L E L ++ L ++ K K++A + +LK++ L+ + E ++Q ++ D EQ Sbjct: 2298 RQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2356 Query: 392 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE----LLRK 447 + +LA + +G + E + + EA KL+ AE RK Sbjct: 2357 MAQQLA----EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2412 Query: 448 NA-DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKREL--EAK 504 A + ++L T+ + +E + + L Q +Q ++E +L E +LE+ K +L EAK Sbjct: 2413 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAK 2471 Query: 505 AGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA-- 562 +L + EQ E + + +EKD+L R E + + L ++ A Sbjct: 2472 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2531 Query: 563 -ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSK 621 L EQQR Q+ + + RL S E+ R+ + A E Q+ + + Sbjct: 2532 QQLREEQQRQQQQMEQERQRLV--ASMEEARRR----------QHEAEEGVRRKQEELQQ 2579 Query: 622 LDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAAD 681 L+ + + L Q + + LEE H L + +A A T+ Sbjct: 2580 LEQ----QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK------- 2628 Query: 682 TIING--GATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQ 729 T+ NG A +P R+ A+ L+ G L ++ R Q Sbjct: 2629 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2678 Score = 49.3 bits (116), Expect = 2e-05 Identities = 151/706 (21%), Positives = 265/706 (37%), Gaps = 78/706 (11%) Query: 334 LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 393 L I + E+LR+ E++K EAQ A L ++ A + L++ R Q + + LR Sbjct: 1097 LVIRGTQGAEEVLRAHEEQLK-EAQAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALR 1154 Query: 394 HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 453 EL R AQ GER Q E + + R +L E+ ++ R+ + Sbjct: 1155 DEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1211 Query: 454 QLTVTQQSQEEVARVKEQLAFQVEQVKR---ESELKLEEKSDQLEKLKRELEAKAGELAR 510 QL ++S + + + + EQ++ + E+ Q + L E+E ++ Sbjct: 1212 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1271 Query: 511 AQEALSHTEQSKSELSSRLDTLSAEKDAL------------SGAVRQREADL-------- 550 Q + + +L T A+ + + S +V Q DL Sbjct: 1272 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1331 Query: 551 -LAAQ--SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA 607 L +Q + ET + E++ + Q++ E + RLAE E+ + +QR L E A + Sbjct: 1332 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE--KQRQLAEAHAQAKAQ 1389 Query: 608 AAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA 667 A A LQ ++ + + R ++ D + + + A+ A A Sbjct: 1390 AEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1446 Query: 668 LVAALTRFS--------HLAADTIINGGATSHL-APTDPADRLIDTCRECGARALELMGQ 718 + R L A GGA L A A+ R+ A L Q Sbjct: 1447 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1506 Query: 719 LQDQQALRHMQ----ASLVRTPL------QGILQLGQELKPKSLDVRQEELGAVVDKEMA 768 +QD+ + AS V+ Q LQ +EL+ ++ + + A V++ Sbjct: 1507 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER-AR 1565 Query: 769 ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 828 A+E A R E + Q++ AS K ER L + +R Q E Sbjct: 1566 QVQVALETAQRSAEAEL-QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1624 Query: 829 VESGRGAATQQEFY------AKNSRWTEGLISASKAVGWG-ATQLVEAADKVVLHTGKYE 881 + A + E + A R ++ K++ A + E A++ GK E Sbjct: 1625 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1684 Query: 882 ELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ-- 939 E V E+A +L ++ L+ QE R + A T+ G++Q Sbjct: 1685 EQAVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIR--------LRAETEQGEQQRQ 1734 Query: 940 -IEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGE 983 +E+ + K+QE+E ++ + E + L A + R E Sbjct: 1735 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1780 Score = 45.1 bits (105), Expect = 4e-04 Identities = 136/688 (19%), Positives = 264/688 (38%), Gaps = 67/688 (9%) Query: 337 ESLKREVEMLRS----ELEKIKLEAQR---YIAQLKSQVNALEGELEEQRKQKQKALVDN 389 +SL+R+V+++RS +K E QR + +L Q + + + + + + Sbjct: 901 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 960 Query: 390 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 449 E + QL QG +EE+ + +E + +L+ + E VH L + Sbjct: 961 E---YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1017 Query: 450 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--LKLEEKSDQLEKLKRELEAKAGE 507 + A++ Q++ E L V ++ E+E L L E S L+ ELE G+ Sbjct: 1018 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1077 Query: 508 LARAQE--------------ALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA 553 L + + + T+ ++ L + + L E A+ + + EA + Sbjct: 1078 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASL 1136 Query: 554 QSLVRETEAA-----LSREQQRSSQEQGE-LQGRLAERESQEQGLRQR---LLDEQFAVL 604 + L + EA R++ R +QE GE LQ R ER+ + + R+R LL+ AVL Sbjct: 1137 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1196 Query: 605 -----RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYL 659 R E G + DPL + R QE + A+ + + Sbjct: 1197 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA-----RRRQEQIQAMPLADSQAVR-- 1249 Query: 660 TSLADASALVAALTRFSHLA------ADTIINGGATSHLAPTDPADRLIDTCRECGARAL 713 L AL+ + R A IN L +L + Sbjct: 1250 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1309 Query: 714 ELMGQ--LQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 771 + + +Q+ LR + L Q I + + L+ + R E ++E A Sbjct: 1310 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1369 Query: 772 AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 831 A + R++ + QA+ + E+ +R+ +A S+Q+E+ + Sbjct: 1370 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1429 Query: 832 GRGAATQQEFYAKNSRWTE-GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEI 890 + + + + A+ + E + + + QL EA ++ G EL + Sbjct: 1430 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATER--QRGGAEGEL-----QA 1481 Query: 891 AASTAQLVAASKVKANKHSPHLSR-LQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 949 + A+ A K +A + + L R +Q+ S+ + + + K+ E ++ Sbjct: 1482 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-LQ 1540 Query: 950 GLSLIKLKKQEMETQVRVLELEKTLEAE 977 L ++L+ +E E ++R E+E+ + + Sbjct: 1541 ALEELRLQAEEAERRLRQAEVERARQVQ 1568 >gi|41322919 plectin 1 isoform 8 [Homo sapiens] Length = 4547 Score = 79.0 bits (193), Expect = 2e-14 Identities = 170/688 (24%), Positives = 284/688 (41%), Gaps = 102/688 (14%) Query: 334 LQIESLKR-------EVEMLRS---ELEKIKLEAQRYIAQLKSQV-----NALEGELE-- 376 LQ+E+ +R E++ LR+ E E K +AQ +L+ QV + E+E Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1518 Query: 377 -------EQRKQKQKALVDNEQLR--HELAQLRAAQLEGERSQGLREEAERKASATEARY 427 E ++KQ+AL E+LR E A+ R Q E ER++ ++ E + EA Sbjct: 1519 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-- 1576 Query: 428 NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 487 +L+ K + A+L R + + + V Q +E R ++Q + E+ + E+E +L Sbjct: 1577 -ELQSKRASFAEKTAQLERSLQE--EHVAVAQLREEAERRAQQQA--EAERAREEAEREL 1631 Query: 488 EE---KSDQLEKLKRELEAKAGELARAQ-EALSHTEQSKSELSSRLDTLSAEKDALSGAV 543 E K+++ +L+ + E A + + AQ EA E+++ E R A AV Sbjct: 1632 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAV 1684 Query: 544 RQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 603 RQRE LA Q L ++ + A QQR + EQ EL AE E EQ +++LL+E+ A Sbjct: 1685 RQRE---LAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQ--QRQLLEEELAR 1738 Query: 604 LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA 663 L+ AA A Q+ L+ L L S+A+ ++ ST E+ + Sbjct: 1739 LQREAAAATQKRQE----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR------ 1788 Query: 664 DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 723 L A RF LA + A A + A R E AR Q + Sbjct: 1789 ----LEAEAGRFRELAEE------AARLRALAEEAKRQRQLAEEDAAR--------QRAE 1830 Query: 724 ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR--- 780 A R + L L+ E+ K + E L + + E E A + Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1890 Query: 781 IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG-AATQQ 839 IE+ + Q R AS +LE + ++ D ++ R + +L+ ++ G A + Sbjct: 1891 IEERLAQLRKASDS-ELERQKGLVE---DTLRQRRQVEEEILALKASFEKAAAGKAELEL 1946 Query: 840 EFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEEL--IVCSHEIAASTAQL 897 E S + L S +A A Q AA++ E + + + E AA + Sbjct: 1947 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2006 Query: 898 VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLK 957 + RL+E R E A + + ++ Q++++ + K Sbjct: 2007 ALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEE------------K 2052 Query: 958 KQEMETQVRVLELEKTLEAERMRLGELR 985 Q + EL++TL+ E+ L +LR Sbjct: 2053 AHAFAVQQKEQELQQTLQQEQSVLDQLR 2080 Score = 77.8 bits (190), Expect = 5e-14 Identities = 158/768 (20%), Positives = 296/768 (38%), Gaps = 96/768 (12%) Query: 330 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 389 +D Q ++ E+ L++ EK A A+L+ ++ + E+ + K++A ++ Sbjct: 1914 EDTLRQRRQVEEEILALKASFEK----AAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1969 Query: 390 EQLRHELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 445 + R A+ + E E +S EEA R+ A +LK K E A L Sbjct: 1970 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRL 2024 Query: 446 RKNAD--TAKQLTVTQQSQEEVARVKEQL-AFQVEQVKRESELKLEEKSDQLEKLKRELE 502 R+ A+ +A+QL + Q++ ++ + +E+ AF V+Q ++E + L+++ L++L+ E E Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2084 Query: 503 AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 562 A A+EA E+ ++ +++ K + + R AA+ L +E E Sbjct: 2085 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144 Query: 563 ALSREQQRSSQEQGELQGRLAERESQ----EQGLRQR----------------------L 596 +R Q + Q AE E EQ LRQ+ L Sbjct: 2145 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2204 Query: 597 LDEQFAVLRGAAAEAAGILQDAVSKLD---------DPLHLRCTSSPDYLVSRAQEALDA 647 LDE+ L+ A EAA +L L R + L+ R ++ Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264 Query: 648 VSTLE-EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 706 E E Q A S R LA + + A + + + + R Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324 Query: 707 -ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELK--PKSLDV---RQEELG 760 + A L+ +L +QA R L Q QL +E + ++L+ RQ E+ Sbjct: 2325 LKAEAELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2379 Query: 761 AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 820 A ++ + R ED + A E+ E++ T+L ++ + Sbjct: 2380 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR--TELATQEKVTLVQ 2432 Query: 821 STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLH---- 876 + +Q++ +S A +E A+ R E L +K + + ++ + +L Sbjct: 2433 TLEIQRQ--QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490 Query: 877 -----TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVA 931 + + L+ I A+L + + K Q + + + +VA Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2550 Query: 932 STKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGE----LRKQ 987 S + + + + + G+ + + Q++E Q R + E+ L E RL E L +Q Sbjct: 2551 SMEEARRRQHEAE----EGVRRKQEELQQLEQQRR--QQEELLAEENQRLREQLQLLEEQ 2604 Query: 988 HYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLD 1035 H A+ + EEV A +++ + L P+ +H D Sbjct: 2605 H----RAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEPEHSFD 2647 Score = 73.9 bits (180), Expect = 7e-13 Identities = 151/697 (21%), Positives = 281/697 (40%), Gaps = 81/697 (11%) Query: 344 EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA-- 401 + L +E E I+L A+ Q + Q LE EL +++ A ++L ELA++RA Sbjct: 1707 QRLAAEQELIRLRAET--EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1764 Query: 402 -------AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 454 A+ E E S+ E+++++ A R+ +L E+ + L AE ++ A++ Sbjct: 1765 EVLLASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARL-RALAEEAKRQRQLAEE 1822 Query: 455 LTVTQQSQEEVARVKEQLAF-QVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQE 513 Q+++ E ++ A + ++K E+E+ L+EK + E+L+R E +A + R +E Sbjct: 1823 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1882 Query: 514 ALSHTEQSKSELSSRL--------DTLSAEKDALSGAVRQR---EADLLAAQSLVR---- 558 Q K+++ RL L +K + +RQR E ++LA ++ Sbjct: 1883 ---QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1939 Query: 559 ---ETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAE 610 E E L R E S+EQ EL+ + + E+ R+R +E+ A E Sbjct: 1940 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999 Query: 611 AAGILQDAV-------SKLDDPLHLRCTSSPDYL--VSRAQEALDAVSTLEEGHAQYLTS 661 AA + A+ +K+++ LR + + + AQEA A L+ + + Sbjct: 2000 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA--AQKRLQAEEKAHAFA 2057 Query: 662 LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECG-----ARALELM 716 + + + D + + A + + + RE E + Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2117 Query: 717 GQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIED 776 Q ++QA QA L+ +E + ++ Q E A+ K+ A A +E Sbjct: 2118 KQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQ--AADAEMEK 2169 Query: 777 AVRRIEDMMNQARHASS-----GVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 831 + E + Q ++LE + N + ++ ++ T + + ++ E Sbjct: 2170 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2229 Query: 832 GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQ--LVEAADKVVLHTGKYEELIVCSHE 889 Q E +K E A TQ L E A+K+ + L V + E Sbjct: 2230 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2289 Query: 890 IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 949 AA QL A + A + + L+E + V E K+ E ++ + + Sbjct: 2290 -AARLRQL--AEEDLAQQRALAEKMLKEKMQAVQE-----ATRLKAEAELLQQQKELAQE 2341 Query: 950 GLSLIKLKKQEMETQV--RVLELEKTLEAERMRLGEL 984 ++ K++M Q+ ++TLEAER R E+ Sbjct: 2342 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2378 Score = 68.6 bits (166), Expect = 3e-11 Identities = 153/722 (21%), Positives = 289/722 (40%), Gaps = 104/722 (14%) Query: 336 IESLKREVEMLRSELEKIKLEAQRYI-AQLKSQVNALEGELEEQRK-------QKQKALV 387 +E L+ + E L + ++E R + L++ + E EL+ +R Q +++L Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1597 Query: 388 DNE----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 443 + QLR E + Q E ER+ REEAER+ + + N+ + V + Sbjct: 1598 EEHVAVAQLREEAERRAQQQAEAERA---REEAERELERWQLKANEALRLRLQAEEVAQQ 1654 Query: 444 LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE------------------- 484 A+ KQ ++ + +EQ Q E ++E E Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714 Query: 485 -LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL--SG 541 ++L +++Q E+ ++ LE ELAR Q + Q + EL + L + AE + L S Sbjct: 1715 LIRLRAETEQGEQQRQLLEE---ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1771 Query: 542 AVRQREADLLAAQSLVR-ETEAALSRE------QQRSSQEQGELQGRLAERESQEQGLR- 593 A + E+ + +S R E EA RE + R+ E+ + Q +LAE ++ Q Sbjct: 1772 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831 Query: 594 QRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEE 653 +R+L E+ A A EA + +A L + + + L A++ LEE Sbjct: 1832 ERVLAEKLA----AIGEATRLKTEAEIALKEK-----EAENERLRRLAEDEAFQRRRLEE 1882 Query: 654 GHAQYLTSLADASALV-----AALTRFSHLAADTIINGGATSH--LAPTDPADRLIDTCR 706 AQ+ + + A + + L R L DT+ LA ++ Sbjct: 1883 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK-----A 1937 Query: 707 ECGARALEL-MGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV 763 G LEL +G+++ + LR + + + Q L +E + + + R ++ A Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1997 Query: 764 DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT--- 820 ++ AA+E+ V R++ + +AR + E ++ + K ++ Sbjct: 1998 EEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2056 Query: 821 ---------STSLQKE--IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEA 869 +LQ+E +++ RG A A+ + E + A + Q+ EA Sbjct: 2057 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE--EARVQAEREAAQSRRQVEEA 2114 Query: 870 ADKVVLHTGKYEELIVCSHEIAASTAQLVAAS---KVKANKHSPHLSRLQECSRTVNERA 926 E L + E A + AQ AA+ + +A + + ++ ++ + + A Sbjct: 2115 -----------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2163 Query: 927 ANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGELR 985 + K EQ + L+ ++L+ +E + Q +L+ E + L+AE R Sbjct: 2164 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2223 Query: 986 KQ 987 Q Sbjct: 2224 SQ 2225 Score = 66.2 bits (160), Expect = 1e-10 Identities = 90/330 (27%), Positives = 146/330 (44%), Gaps = 63/330 (19%) Query: 335 QIESLKREVEMLRSE----LEKIK--LEAQRYIAQLKSQVNA--------LEGELEEQRK 380 ++E +R E R+E L +++ LE QR +A+ +Q A L+ ++E+ Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402 Query: 381 QKQKALVDNEQ----LRHELAQLRA---AQLEGERSQGLREEAERKASATEARYNKLKEK 433 ++++A VD +Q ++ EL QLR A+++ + Q E R E R +L+ + Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462 Query: 434 HSELVHVHAE----LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEE 489 +E AE LR A+ A+ +Q+QEE R++ Q V+ ES+ K + Sbjct: 1463 ATERQRGGAEGELQALRARAEEAE--AQKRQAQEEAERLRRQ-------VQDESQRKRQA 1513 Query: 490 KSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKD-----ALSGAVR 544 + + ++K E EA A E RA +AL E RL E+ AL A R Sbjct: 1514 EVELASRVKAEAEA-AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1572 Query: 545 QREADLLAAQSLVRETEAALSR--------------EQQRSSQEQGELQGRLAERESQ-- 588 EA+L + ++ E A L R E +R +Q+Q E + E E + Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632 Query: 589 ------EQGLRQRLLDEQFAVLRG-AAAEA 611 + LR RL E+ A + A AEA Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEA 1662 Score = 65.9 bits (159), Expect = 2e-10 Identities = 151/729 (20%), Positives = 289/729 (39%), Gaps = 107/729 (14%) Query: 330 DDRDLQIESLKREVEMLRSELEKIKL---EAQRYIAQLKSQVNALEGELEEQRKQKQKAL 386 D R ++E L R++ R + + +A+R Q+++ A + EQ +Q+Q L Sbjct: 1196 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1255 Query: 387 VDNEQLRHELAQLRA--------------------AQLEGERSQGLREEAERKASATEAR 426 + E+ ++ + + AQLE S + + + + + Sbjct: 1256 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1315 Query: 427 YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ-SQEEVARVKEQLA---FQVEQVKRE 482 Y L+ +SEL + ++ ++ ++T +++ ++ ++++ A +E+LA +E+ ++ Sbjct: 1316 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1375 Query: 483 SELKLEEKSDQLEKLKRELEAK-AGELARAQEALSHTEQSKSELSSRLDTLSAEKDA-LS 540 +E + K+ Q E+ +EL+ + E+ R +EA +Q K + L L +A + Sbjct: 1376 AEAHAQAKA-QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1434 Query: 541 GAVRQREA---DLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA-------------- 583 RQ EA L + +R L +++ +GELQ A Sbjct: 1435 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1494 Query: 584 -----ERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL- 637 R+ Q++ R+R + + A A AEAA Q A+ L++ L L+ + L Sbjct: 1495 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-LRLQAEEAERRLR 1553 Query: 638 ---VSRAQEALDAVSTLEEGHAQYL----TSLADASALVAALTRFSHLAADTIINGGATS 690 V RA++ A+ T + L S A+ +A + + H+A + A Sbjct: 1554 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV-AQLREEAER 1612 Query: 691 HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPK 750 A+R RE R LE QL+ +ALR LQ + + K Sbjct: 1613 RAQQQAEAER----AREEAERELE-RWQLKANEALRLR------------LQAEEVAQQK 1655 Query: 751 SL-DVRQEELGAVVDKEMAATSAAIEDAVRRIE------DMMNQARHASSGVKLEVNERI 803 SL E+ ++E A E AVR+ E + Q ++ +L + + Sbjct: 1656 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1715 Query: 804 LNSCTDLMKA---IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLI-SASKAV 859 + + + +LL LQ+E + + + AK E L+ S ++A Sbjct: 1716 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1775 Query: 860 GWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECS 919 + ++ ++ G++ EL + E A A A + + + E Sbjct: 1776 EESRSTSEKSKQRLEAEAGRFREL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1832 Query: 920 RTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM 979 R + E+ A + +T+ E + I LK++E E + R+ L + +R Sbjct: 1833 RVLAEKLAAIGEATRLKTE-------------AEIALKEKEAENE-RLRRLAEDEAFQRR 1878 Query: 980 RLGELRKQH 988 RL E QH Sbjct: 1879 RLEEQAAQH 1887 Score = 62.4 bits (150), Expect = 2e-09 Identities = 94/410 (22%), Positives = 167/410 (40%), Gaps = 41/410 (10%) Query: 332 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 391 R L E L ++ L ++ K K++A + +LK++ L+ + E ++Q ++ D EQ Sbjct: 2294 RQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352 Query: 392 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE----LLRK 447 + +LA + +G + E + + EA KL+ AE RK Sbjct: 2353 MAQQLA----EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408 Query: 448 NA-DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKREL--EAK 504 A + ++L T+ + +E + + L Q +Q ++E +L E +LE+ K +L EAK Sbjct: 2409 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAK 2467 Query: 505 AGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA-- 562 +L + EQ E + + +EKD+L R E + + L ++ A Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2527 Query: 563 -ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSK 621 L EQQR Q+ + + RL S E+ R+ + A E Q+ + + Sbjct: 2528 QQLREEQQRQQQQMEQERQRLV--ASMEEARRR----------QHEAEEGVRRKQEELQQ 2575 Query: 622 LDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAAD 681 L+ + + L Q + + LEE H L + +A A T+ Sbjct: 2576 LEQ----QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK------- 2624 Query: 682 TIING--GATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQ 729 T+ NG A +P R+ A+ L+ G L ++ R Q Sbjct: 2625 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2674 Score = 49.3 bits (116), Expect = 2e-05 Identities = 151/706 (21%), Positives = 265/706 (37%), Gaps = 78/706 (11%) Query: 334 LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 393 L I + E+LR+ E++K EAQ A L ++ A + L++ R Q + + LR Sbjct: 1093 LVIRGTQGAEEVLRAHEEQLK-EAQAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALR 1150 Query: 394 HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 453 EL R AQ GER Q E + + R +L E+ ++ R+ + Sbjct: 1151 DEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1207 Query: 454 QLTVTQQSQEEVARVKEQLAFQVEQVKR---ESELKLEEKSDQLEKLKRELEAKAGELAR 510 QL ++S + + + + EQ++ + E+ Q + L E+E ++ Sbjct: 1208 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1267 Query: 511 AQEALSHTEQSKSELSSRLDTLSAEKDAL------------SGAVRQREADL-------- 550 Q + + +L T A+ + + S +V Q DL Sbjct: 1268 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1327 Query: 551 -LAAQ--SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA 607 L +Q + ET + E++ + Q++ E + RLAE E+ + +QR L E A + Sbjct: 1328 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE--KQRQLAEAHAQAKAQ 1385 Query: 608 AAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA 667 A A LQ ++ + + R ++ D + + + A+ A A Sbjct: 1386 AEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442 Query: 668 LVAALTRFS--------HLAADTIINGGATSHL-APTDPADRLIDTCRECGARALELMGQ 718 + R L A GGA L A A+ R+ A L Q Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502 Query: 719 LQDQQALRHMQ----ASLVRTPL------QGILQLGQELKPKSLDVRQEELGAVVDKEMA 768 +QD+ + AS V+ Q LQ +EL+ ++ + + A V++ Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER-AR 1561 Query: 769 ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 828 A+E A R E + Q++ AS K ER L + +R Q E Sbjct: 1562 QVQVALETAQRSAEAEL-QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1620 Query: 829 VESGRGAATQQEFY------AKNSRWTEGLISASKAVGWG-ATQLVEAADKVVLHTGKYE 881 + A + E + A R ++ K++ A + E A++ GK E Sbjct: 1621 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1680 Query: 882 ELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ-- 939 E V E+A +L ++ L+ QE R + A T+ G++Q Sbjct: 1681 EQAVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIR--------LRAETEQGEQQRQ 1730 Query: 940 -IEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGE 983 +E+ + K+QE+E ++ + E + L A + R E Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776 Score = 45.1 bits (105), Expect = 4e-04 Identities = 136/688 (19%), Positives = 264/688 (38%), Gaps = 67/688 (9%) Query: 337 ESLKREVEMLRS----ELEKIKLEAQR---YIAQLKSQVNALEGELEEQRKQKQKALVDN 389 +SL+R+V+++RS +K E QR + +L Q + + + + + + Sbjct: 897 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 956 Query: 390 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 449 E + QL QG +EE+ + +E + +L+ + E VH L + Sbjct: 957 E---YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1013 Query: 450 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--LKLEEKSDQLEKLKRELEAKAGE 507 + A++ Q++ E L V ++ E+E L L E S L+ ELE G+ Sbjct: 1014 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1073 Query: 508 LARAQE--------------ALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA 553 L + + + T+ ++ L + + L E A+ + + EA + Sbjct: 1074 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASL 1132 Query: 554 QSLVRETEAA-----LSREQQRSSQEQGE-LQGRLAERESQEQGLRQR---LLDEQFAVL 604 + L + EA R++ R +QE GE LQ R ER+ + + R+R LL+ AVL Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1192 Query: 605 -----RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYL 659 R E G + DPL + R QE + A+ + + Sbjct: 1193 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA-----RRRQEQIQAMPLADSQAVR-- 1245 Query: 660 TSLADASALVAALTRFSHLA------ADTIINGGATSHLAPTDPADRLIDTCRECGARAL 713 L AL+ + R A IN L +L + Sbjct: 1246 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1305 Query: 714 ELMGQ--LQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 771 + + +Q+ LR + L Q I + + L+ + R E ++E A Sbjct: 1306 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1365 Query: 772 AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 831 A + R++ + QA+ + E+ +R+ +A S+Q+E+ + Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425 Query: 832 GRGAATQQEFYAKNSRWTE-GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEI 890 + + + + A+ + E + + + QL EA ++ G EL + Sbjct: 1426 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATER--QRGGAEGEL-----QA 1477 Query: 891 AASTAQLVAASKVKANKHSPHLSR-LQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 949 + A+ A K +A + + L R +Q+ S+ + + + K+ E ++ Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-LQ 1536 Query: 950 GLSLIKLKKQEMETQVRVLELEKTLEAE 977 L ++L+ +E E ++R E+E+ + + Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQ 1564 >gi|41322910 plectin 1 isoform 7 [Homo sapiens] Length = 4515 Score = 79.0 bits (193), Expect = 2e-14 Identities = 170/688 (24%), Positives = 284/688 (41%), Gaps = 102/688 (14%) Query: 334 LQIESLKR-------EVEMLRS---ELEKIKLEAQRYIAQLKSQV-----NALEGELE-- 376 LQ+E+ +R E++ LR+ E E K +AQ +L+ QV + E+E Sbjct: 1427 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1486 Query: 377 -------EQRKQKQKALVDNEQLR--HELAQLRAAQLEGERSQGLREEAERKASATEARY 427 E ++KQ+AL E+LR E A+ R Q E ER++ ++ E + EA Sbjct: 1487 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-- 1544 Query: 428 NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 487 +L+ K + A+L R + + + V Q +E R ++Q + E+ + E+E +L Sbjct: 1545 -ELQSKRASFAEKTAQLERSLQE--EHVAVAQLREEAERRAQQQA--EAERAREEAEREL 1599 Query: 488 EE---KSDQLEKLKRELEAKAGELARAQ-EALSHTEQSKSELSSRLDTLSAEKDALSGAV 543 E K+++ +L+ + E A + + AQ EA E+++ E R A AV Sbjct: 1600 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAV 1652 Query: 544 RQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 603 RQRE LA Q L ++ + A QQR + EQ EL AE E EQ +++LL+E+ A Sbjct: 1653 RQRE---LAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQ--QRQLLEEELAR 1706 Query: 604 LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA 663 L+ AA A Q+ L+ L L S+A+ ++ ST E+ + Sbjct: 1707 LQREAAAATQKRQE----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR------ 1756 Query: 664 DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 723 L A RF LA + A A + A R E AR Q + Sbjct: 1757 ----LEAEAGRFRELAEE------AARLRALAEEAKRQRQLAEEDAAR--------QRAE 1798 Query: 724 ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR--- 780 A R + L L+ E+ K + E L + + E E A + Sbjct: 1799 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1858 Query: 781 IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG-AATQQ 839 IE+ + Q R AS +LE + ++ D ++ R + +L+ ++ G A + Sbjct: 1859 IEERLAQLRKASDS-ELERQKGLVE---DTLRQRRQVEEEILALKASFEKAAAGKAELEL 1914 Query: 840 EFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEEL--IVCSHEIAASTAQL 897 E S + L S +A A Q AA++ E + + + E AA + Sbjct: 1915 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1974 Query: 898 VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLK 957 + RL+E R E A + + ++ Q++++ + K Sbjct: 1975 ALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEE------------K 2020 Query: 958 KQEMETQVRVLELEKTLEAERMRLGELR 985 Q + EL++TL+ E+ L +LR Sbjct: 2021 AHAFAVQQKEQELQQTLQQEQSVLDQLR 2048 Score = 77.8 bits (190), Expect = 5e-14 Identities = 158/768 (20%), Positives = 296/768 (38%), Gaps = 96/768 (12%) Query: 330 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 389 +D Q ++ E+ L++ EK A A+L+ ++ + E+ + K++A ++ Sbjct: 1882 EDTLRQRRQVEEEILALKASFEK----AAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1937 Query: 390 EQLRHELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 445 + R A+ + E E +S EEA R+ A +LK K E A L Sbjct: 1938 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRL 1992 Query: 446 RKNAD--TAKQLTVTQQSQEEVARVKEQL-AFQVEQVKRESELKLEEKSDQLEKLKRELE 502 R+ A+ +A+QL + Q++ ++ + +E+ AF V+Q ++E + L+++ L++L+ E E Sbjct: 1993 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2052 Query: 503 AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 562 A A+EA E+ ++ +++ K + + R AA+ L +E E Sbjct: 2053 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2112 Query: 563 ALSREQQRSSQEQGELQGRLAERESQ----EQGLRQR----------------------L 596 +R Q + Q AE E EQ LRQ+ L Sbjct: 2113 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2172 Query: 597 LDEQFAVLRGAAAEAAGILQDAVSKLD---------DPLHLRCTSSPDYLVSRAQEALDA 647 LDE+ L+ A EAA +L L R + L+ R ++ Sbjct: 2173 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2232 Query: 648 VSTLE-EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 706 E E Q A S R LA + + A + + + + R Sbjct: 2233 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2292 Query: 707 -ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELK--PKSLDV---RQEELG 760 + A L+ +L +QA R L Q QL +E + ++L+ RQ E+ Sbjct: 2293 LKAEAELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2347 Query: 761 AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 820 A ++ + R ED + A E+ E++ T+L ++ + Sbjct: 2348 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR--TELATQEKVTLVQ 2400 Query: 821 STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLH---- 876 + +Q++ +S A +E A+ R E L +K + + ++ + +L Sbjct: 2401 TLEIQRQ--QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2458 Query: 877 -----TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVA 931 + + L+ I A+L + + K Q + + + +VA Sbjct: 2459 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2518 Query: 932 STKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGE----LRKQ 987 S + + + + + G+ + + Q++E Q R + E+ L E RL E L +Q Sbjct: 2519 SMEEARRRQHEAE----EGVRRKQEELQQLEQQRR--QQEELLAEENQRLREQLQLLEEQ 2572 Query: 988 HYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLD 1035 H A+ + EEV A +++ + L P+ +H D Sbjct: 2573 H----RAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEPEHSFD 2615 Score = 73.9 bits (180), Expect = 7e-13 Identities = 151/697 (21%), Positives = 281/697 (40%), Gaps = 81/697 (11%) Query: 344 EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA-- 401 + L +E E I+L A+ Q + Q LE EL +++ A ++L ELA++RA Sbjct: 1675 QRLAAEQELIRLRAET--EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1732 Query: 402 -------AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 454 A+ E E S+ E+++++ A R+ +L E+ + L AE ++ A++ Sbjct: 1733 EVLLASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARL-RALAEEAKRQRQLAEE 1790 Query: 455 LTVTQQSQEEVARVKEQLAF-QVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQE 513 Q+++ E ++ A + ++K E+E+ L+EK + E+L+R E +A + R +E Sbjct: 1791 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1850 Query: 514 ALSHTEQSKSELSSRL--------DTLSAEKDALSGAVRQR---EADLLAAQSLVR---- 558 Q K+++ RL L +K + +RQR E ++LA ++ Sbjct: 1851 ---QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1907 Query: 559 ---ETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAE 610 E E L R E S+EQ EL+ + + E+ R+R +E+ A E Sbjct: 1908 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1967 Query: 611 AAGILQDAV-------SKLDDPLHLRCTSSPDYL--VSRAQEALDAVSTLEEGHAQYLTS 661 AA + A+ +K+++ LR + + + AQEA A L+ + + Sbjct: 1968 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA--AQKRLQAEEKAHAFA 2025 Query: 662 LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECG-----ARALELM 716 + + + D + + A + + + RE E + Sbjct: 2026 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2085 Query: 717 GQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIED 776 Q ++QA QA L+ +E + ++ Q E A+ K+ A A +E Sbjct: 2086 KQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQ--AADAEMEK 2137 Query: 777 AVRRIEDMMNQARHASS-----GVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 831 + E + Q ++LE + N + ++ ++ T + + ++ E Sbjct: 2138 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2197 Query: 832 GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQ--LVEAADKVVLHTGKYEELIVCSHE 889 Q E +K E A TQ L E A+K+ + L V + E Sbjct: 2198 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2257 Query: 890 IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 949 AA QL A + A + + L+E + V E K+ E ++ + + Sbjct: 2258 -AARLRQL--AEEDLAQQRALAEKMLKEKMQAVQE-----ATRLKAEAELLQQQKELAQE 2309 Query: 950 GLSLIKLKKQEMETQV--RVLELEKTLEAERMRLGEL 984 ++ K++M Q+ ++TLEAER R E+ Sbjct: 2310 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2346 Score = 68.6 bits (166), Expect = 3e-11 Identities = 153/722 (21%), Positives = 289/722 (40%), Gaps = 104/722 (14%) Query: 336 IESLKREVEMLRSELEKIKLEAQRYI-AQLKSQVNALEGELEEQRK-------QKQKALV 387 +E L+ + E L + ++E R + L++ + E EL+ +R Q +++L Sbjct: 1506 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1565 Query: 388 DNE----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 443 + QLR E + Q E ER+ REEAER+ + + N+ + V + Sbjct: 1566 EEHVAVAQLREEAERRAQQQAEAERA---REEAERELERWQLKANEALRLRLQAEEVAQQ 1622 Query: 444 LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE------------------- 484 A+ KQ ++ + +EQ Q E ++E E Sbjct: 1623 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1682 Query: 485 -LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL--SG 541 ++L +++Q E+ ++ LE ELAR Q + Q + EL + L + AE + L S Sbjct: 1683 LIRLRAETEQGEQQRQLLEE---ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1739 Query: 542 AVRQREADLLAAQSLVR-ETEAALSRE------QQRSSQEQGELQGRLAERESQEQGLR- 593 A + E+ + +S R E EA RE + R+ E+ + Q +LAE ++ Q Sbjct: 1740 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1799 Query: 594 QRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEE 653 +R+L E+ A A EA + +A L + + + L A++ LEE Sbjct: 1800 ERVLAEKLA----AIGEATRLKTEAEIALKEK-----EAENERLRRLAEDEAFQRRRLEE 1850 Query: 654 GHAQYLTSLADASALV-----AALTRFSHLAADTIINGGATSH--LAPTDPADRLIDTCR 706 AQ+ + + A + + L R L DT+ LA ++ Sbjct: 1851 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK-----A 1905 Query: 707 ECGARALEL-MGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV 763 G LEL +G+++ + LR + + + Q L +E + + + R ++ A Sbjct: 1906 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1965 Query: 764 DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT--- 820 ++ AA+E+ V R++ + +AR + E ++ + K ++ Sbjct: 1966 EEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2024 Query: 821 ---------STSLQKE--IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEA 869 +LQ+E +++ RG A A+ + E + A + Q+ EA Sbjct: 2025 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE--EARVQAEREAAQSRRQVEEA 2082 Query: 870 ADKVVLHTGKYEELIVCSHEIAASTAQLVAAS---KVKANKHSPHLSRLQECSRTVNERA 926 E L + E A + AQ AA+ + +A + + ++ ++ + + A Sbjct: 2083 -----------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2131 Query: 927 ANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGELR 985 + K EQ + L+ ++L+ +E + Q +L+ E + L+AE R Sbjct: 2132 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2191 Query: 986 KQ 987 Q Sbjct: 2192 SQ 2193 Score = 66.2 bits (160), Expect = 1e-10 Identities = 90/330 (27%), Positives = 146/330 (44%), Gaps = 63/330 (19%) Query: 335 QIESLKREVEMLRSE----LEKIK--LEAQRYIAQLKSQVNA--------LEGELEEQRK 380 ++E +R E R+E L +++ LE QR +A+ +Q A L+ ++E+ Sbjct: 1311 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1370 Query: 381 QKQKALVDNEQ----LRHELAQLRA---AQLEGERSQGLREEAERKASATEARYNKLKEK 433 ++++A VD +Q ++ EL QLR A+++ + Q E R E R +L+ + Sbjct: 1371 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1430 Query: 434 HSELVHVHAE----LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEE 489 +E AE LR A+ A+ +Q+QEE R++ Q V+ ES+ K + Sbjct: 1431 ATERQRGGAEGELQALRARAEEAE--AQKRQAQEEAERLRRQ-------VQDESQRKRQA 1481 Query: 490 KSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKD-----ALSGAVR 544 + + ++K E EA A E RA +AL E RL E+ AL A R Sbjct: 1482 EVELASRVKAEAEA-AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1540 Query: 545 QREADLLAAQSLVRETEAALSR--------------EQQRSSQEQGELQGRLAERESQ-- 588 EA+L + ++ E A L R E +R +Q+Q E + E E + Sbjct: 1541 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1600 Query: 589 ------EQGLRQRLLDEQFAVLRG-AAAEA 611 + LR RL E+ A + A AEA Sbjct: 1601 RWQLKANEALRLRLQAEEVAQQKSLAQAEA 1630 Score = 65.9 bits (159), Expect = 2e-10 Identities = 151/729 (20%), Positives = 289/729 (39%), Gaps = 107/729 (14%) Query: 330 DDRDLQIESLKREVEMLRSELEKIKL---EAQRYIAQLKSQVNALEGELEEQRKQKQKAL 386 D R ++E L R++ R + + +A+R Q+++ A + EQ +Q+Q L Sbjct: 1164 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1223 Query: 387 VDNEQLRHELAQLRA--------------------AQLEGERSQGLREEAERKASATEAR 426 + E+ ++ + + AQLE S + + + + + Sbjct: 1224 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1283 Query: 427 YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ-SQEEVARVKEQLA---FQVEQVKRE 482 Y L+ +SEL + ++ ++ ++T +++ ++ ++++ A +E+LA +E+ ++ Sbjct: 1284 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1343 Query: 483 SELKLEEKSDQLEKLKRELEAK-AGELARAQEALSHTEQSKSELSSRLDTLSAEKDA-LS 540 +E + K+ Q E+ +EL+ + E+ R +EA +Q K + L L +A + Sbjct: 1344 AEAHAQAKA-QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1402 Query: 541 GAVRQREA---DLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA-------------- 583 RQ EA L + +R L +++ +GELQ A Sbjct: 1403 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1462 Query: 584 -----ERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL- 637 R+ Q++ R+R + + A A AEAA Q A+ L++ L L+ + L Sbjct: 1463 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-LRLQAEEAERRLR 1521 Query: 638 ---VSRAQEALDAVSTLEEGHAQYL----TSLADASALVAALTRFSHLAADTIINGGATS 690 V RA++ A+ T + L S A+ +A + + H+A + A Sbjct: 1522 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV-AQLREEAER 1580 Query: 691 HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPK 750 A+R RE R LE QL+ +ALR LQ + + K Sbjct: 1581 RAQQQAEAER----AREEAERELE-RWQLKANEALRLR------------LQAEEVAQQK 1623 Query: 751 SL-DVRQEELGAVVDKEMAATSAAIEDAVRRIE------DMMNQARHASSGVKLEVNERI 803 SL E+ ++E A E AVR+ E + Q ++ +L + + Sbjct: 1624 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1683 Query: 804 LNSCTDLMKA---IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLI-SASKAV 859 + + + +LL LQ+E + + + AK E L+ S ++A Sbjct: 1684 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1743 Query: 860 GWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECS 919 + ++ ++ G++ EL + E A A A + + + E Sbjct: 1744 EESRSTSEKSKQRLEAEAGRFREL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1800 Query: 920 RTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM 979 R + E+ A + +T+ E + I LK++E E + R+ L + +R Sbjct: 1801 RVLAEKLAAIGEATRLKTE-------------AEIALKEKEAENE-RLRRLAEDEAFQRR 1846 Query: 980 RLGELRKQH 988 RL E QH Sbjct: 1847 RLEEQAAQH 1855 Score = 62.4 bits (150), Expect = 2e-09 Identities = 94/410 (22%), Positives = 167/410 (40%), Gaps = 41/410 (10%) Query: 332 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 391 R L E L ++ L ++ K K++A + +LK++ L+ + E ++Q ++ D EQ Sbjct: 2262 RQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2320 Query: 392 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE----LLRK 447 + +LA + +G + E + + EA KL+ AE RK Sbjct: 2321 MAQQLA----EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2376 Query: 448 NA-DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKREL--EAK 504 A + ++L T+ + +E + + L Q +Q ++E +L E +LE+ K +L EAK Sbjct: 2377 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAK 2435 Query: 505 AGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA-- 562 +L + EQ E + + +EKD+L R E + + L ++ A Sbjct: 2436 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2495 Query: 563 -ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSK 621 L EQQR Q+ + + RL S E+ R+ + A E Q+ + + Sbjct: 2496 QQLREEQQRQQQQMEQERQRLV--ASMEEARRR----------QHEAEEGVRRKQEELQQ 2543 Query: 622 LDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAAD 681 L+ + + L Q + + LEE H L + +A A T+ Sbjct: 2544 LEQ----QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK------- 2592 Query: 682 TIING--GATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQ 729 T+ NG A +P R+ A+ L+ G L ++ R Q Sbjct: 2593 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2642 Score = 49.3 bits (116), Expect = 2e-05 Identities = 151/706 (21%), Positives = 265/706 (37%), Gaps = 78/706 (11%) Query: 334 LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 393 L I + E+LR+ E++K EAQ A L ++ A + L++ R Q + + LR Sbjct: 1061 LVIRGTQGAEEVLRAHEEQLK-EAQAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALR 1118 Query: 394 HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 453 EL R AQ GER Q E + + R +L E+ ++ R+ + Sbjct: 1119 DEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1175 Query: 454 QLTVTQQSQEEVARVKEQLAFQVEQVKR---ESELKLEEKSDQLEKLKRELEAKAGELAR 510 QL ++S + + + + EQ++ + E+ Q + L E+E ++ Sbjct: 1176 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1235 Query: 511 AQEALSHTEQSKSELSSRLDTLSAEKDAL------------SGAVRQREADL-------- 550 Q + + +L T A+ + + S +V Q DL Sbjct: 1236 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1295 Query: 551 -LAAQ--SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA 607 L +Q + ET + E++ + Q++ E + RLAE E+ + +QR L E A + Sbjct: 1296 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE--KQRQLAEAHAQAKAQ 1353 Query: 608 AAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA 667 A A LQ ++ + + R ++ D + + + A+ A A Sbjct: 1354 AEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1410 Query: 668 LVAALTRFS--------HLAADTIINGGATSHL-APTDPADRLIDTCRECGARALELMGQ 718 + R L A GGA L A A+ R+ A L Q Sbjct: 1411 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1470 Query: 719 LQDQQALRHMQ----ASLVRTPL------QGILQLGQELKPKSLDVRQEELGAVVDKEMA 768 +QD+ + AS V+ Q LQ +EL+ ++ + + A V++ Sbjct: 1471 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER-AR 1529 Query: 769 ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 828 A+E A R E + Q++ AS K ER L + +R Q E Sbjct: 1530 QVQVALETAQRSAEAEL-QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1588 Query: 829 VESGRGAATQQEFY------AKNSRWTEGLISASKAVGWG-ATQLVEAADKVVLHTGKYE 881 + A + E + A R ++ K++ A + E A++ GK E Sbjct: 1589 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1648 Query: 882 ELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ-- 939 E V E+A +L ++ L+ QE R + A T+ G++Q Sbjct: 1649 EQAVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIR--------LRAETEQGEQQRQ 1698 Query: 940 -IEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGE 983 +E+ + K+QE+E ++ + E + L A + R E Sbjct: 1699 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1744 Score = 45.1 bits (105), Expect = 4e-04 Identities = 136/688 (19%), Positives = 264/688 (38%), Gaps = 67/688 (9%) Query: 337 ESLKREVEMLRS----ELEKIKLEAQR---YIAQLKSQVNALEGELEEQRKQKQKALVDN 389 +SL+R+V+++RS +K E QR + +L Q + + + + + + Sbjct: 865 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 924 Query: 390 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 449 E + QL QG +EE+ + +E + +L+ + E VH L + Sbjct: 925 E---YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 981 Query: 450 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--LKLEEKSDQLEKLKRELEAKAGE 507 + A++ Q++ E L V ++ E+E L L E S L+ ELE G+ Sbjct: 982 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1041 Query: 508 LARAQE--------------ALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA 553 L + + + T+ ++ L + + L E A+ + + EA + Sbjct: 1042 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASL 1100 Query: 554 QSLVRETEAA-----LSREQQRSSQEQGE-LQGRLAERESQEQGLRQR---LLDEQFAVL 604 + L + EA R++ R +QE GE LQ R ER+ + + R+R LL+ AVL Sbjct: 1101 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1160 Query: 605 -----RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYL 659 R E G + DPL + R QE + A+ + + Sbjct: 1161 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA-----RRRQEQIQAMPLADSQAVR-- 1213 Query: 660 TSLADASALVAALTRFSHLA------ADTIINGGATSHLAPTDPADRLIDTCRECGARAL 713 L AL+ + R A IN L +L + Sbjct: 1214 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1273 Query: 714 ELMGQ--LQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 771 + + +Q+ LR + L Q I + + L+ + R E ++E A Sbjct: 1274 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1333 Query: 772 AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 831 A + R++ + QA+ + E+ +R+ +A S+Q+E+ + Sbjct: 1334 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1393 Query: 832 GRGAATQQEFYAKNSRWTE-GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEI 890 + + + + A+ + E + + + QL EA ++ G EL + Sbjct: 1394 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATER--QRGGAEGEL-----QA 1445 Query: 891 AASTAQLVAASKVKANKHSPHLSR-LQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 949 + A+ A K +A + + L R +Q+ S+ + + + K+ E ++ Sbjct: 1446 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-LQ 1504 Query: 950 GLSLIKLKKQEMETQVRVLELEKTLEAE 977 L ++L+ +E E ++R E+E+ + + Sbjct: 1505 ALEELRLQAEEAERRLRQAEVERARQVQ 1532 >gi|41322916 plectin 1 isoform 6 [Homo sapiens] Length = 4684 Score = 79.0 bits (193), Expect = 2e-14 Identities = 170/688 (24%), Positives = 284/688 (41%), Gaps = 102/688 (14%) Query: 334 LQIESLKR-------EVEMLRS---ELEKIKLEAQRYIAQLKSQV-----NALEGELE-- 376 LQ+E+ +R E++ LR+ E E K +AQ +L+ QV + E+E Sbjct: 1596 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1655 Query: 377 -------EQRKQKQKALVDNEQLR--HELAQLRAAQLEGERSQGLREEAERKASATEARY 427 E ++KQ+AL E+LR E A+ R Q E ER++ ++ E + EA Sbjct: 1656 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-- 1713 Query: 428 NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 487 +L+ K + A+L R + + + V Q +E R ++Q + E+ + E+E +L Sbjct: 1714 -ELQSKRASFAEKTAQLERSLQE--EHVAVAQLREEAERRAQQQA--EAERAREEAEREL 1768 Query: 488 EE---KSDQLEKLKRELEAKAGELARAQ-EALSHTEQSKSELSSRLDTLSAEKDALSGAV 543 E K+++ +L+ + E A + + AQ EA E+++ E R A AV Sbjct: 1769 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAV 1821 Query: 544 RQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 603 RQRE LA Q L ++ + A QQR + EQ EL AE E EQ +++LL+E+ A Sbjct: 1822 RQRE---LAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQ--QRQLLEEELAR 1875 Query: 604 LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA 663 L+ AA A Q+ L+ L L S+A+ ++ ST E+ + Sbjct: 1876 LQREAAAATQKRQE----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR------ 1925 Query: 664 DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 723 L A RF LA + A A + A R E AR Q + Sbjct: 1926 ----LEAEAGRFRELAEE------AARLRALAEEAKRQRQLAEEDAAR--------QRAE 1967 Query: 724 ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR--- 780 A R + L L+ E+ K + E L + + E E A + Sbjct: 1968 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 2027 Query: 781 IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG-AATQQ 839 IE+ + Q R AS +LE + ++ D ++ R + +L+ ++ G A + Sbjct: 2028 IEERLAQLRKASDS-ELERQKGLVE---DTLRQRRQVEEEILALKASFEKAAAGKAELEL 2083 Query: 840 EFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEEL--IVCSHEIAASTAQL 897 E S + L S +A A Q AA++ E + + + E AA + Sbjct: 2084 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2143 Query: 898 VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLK 957 + RL+E R E A + + ++ Q++++ + K Sbjct: 2144 ALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEE------------K 2189 Query: 958 KQEMETQVRVLELEKTLEAERMRLGELR 985 Q + EL++TL+ E+ L +LR Sbjct: 2190 AHAFAVQQKEQELQQTLQQEQSVLDQLR 2217 Score = 77.8 bits (190), Expect = 5e-14 Identities = 158/768 (20%), Positives = 296/768 (38%), Gaps = 96/768 (12%) Query: 330 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 389 +D Q ++ E+ L++ EK A A+L+ ++ + E+ + K++A ++ Sbjct: 2051 EDTLRQRRQVEEEILALKASFEK----AAAGKAELELELGRIRSNAEDTLRSKEQAELEA 2106 Query: 390 EQLRHELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 445 + R A+ + E E +S EEA R+ A +LK K E A L Sbjct: 2107 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRL 2161 Query: 446 RKNAD--TAKQLTVTQQSQEEVARVKEQL-AFQVEQVKRESELKLEEKSDQLEKLKRELE 502 R+ A+ +A+QL + Q++ ++ + +E+ AF V+Q ++E + L+++ L++L+ E E Sbjct: 2162 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2221 Query: 503 AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 562 A A+EA E+ ++ +++ K + + R AA+ L +E E Sbjct: 2222 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2281 Query: 563 ALSREQQRSSQEQGELQGRLAERESQ----EQGLRQR----------------------L 596 +R Q + Q AE E EQ LRQ+ L Sbjct: 2282 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2341 Query: 597 LDEQFAVLRGAAAEAAGILQDAVSKLD---------DPLHLRCTSSPDYLVSRAQEALDA 647 LDE+ L+ A EAA +L L R + L+ R ++ Sbjct: 2342 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2401 Query: 648 VSTLE-EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 706 E E Q A S R LA + + A + + + + R Sbjct: 2402 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2461 Query: 707 -ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELK--PKSLDV---RQEELG 760 + A L+ +L +QA R L Q QL +E + ++L+ RQ E+ Sbjct: 2462 LKAEAELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2516 Query: 761 AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 820 A ++ + R ED + A E+ E++ T+L ++ + Sbjct: 2517 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR--TELATQEKVTLVQ 2569 Query: 821 STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLH---- 876 + +Q++ +S A +E A+ R E L +K + + ++ + +L Sbjct: 2570 TLEIQRQ--QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2627 Query: 877 -----TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVA 931 + + L+ I A+L + + K Q + + + +VA Sbjct: 2628 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2687 Query: 932 STKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGE----LRKQ 987 S + + + + + G+ + + Q++E Q R + E+ L E RL E L +Q Sbjct: 2688 SMEEARRRQHEAE----EGVRRKQEELQQLEQQRR--QQEELLAEENQRLREQLQLLEEQ 2741 Query: 988 HYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLD 1035 H A+ + EEV A +++ + L P+ +H D Sbjct: 2742 H----RAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEPEHSFD 2784 Score = 73.9 bits (180), Expect = 7e-13 Identities = 151/697 (21%), Positives = 281/697 (40%), Gaps = 81/697 (11%) Query: 344 EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA-- 401 + L +E E I+L A+ Q + Q LE EL +++ A ++L ELA++RA Sbjct: 1844 QRLAAEQELIRLRAET--EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1901 Query: 402 -------AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 454 A+ E E S+ E+++++ A R+ +L E+ + L AE ++ A++ Sbjct: 1902 EVLLASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARL-RALAEEAKRQRQLAEE 1959 Query: 455 LTVTQQSQEEVARVKEQLAF-QVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQE 513 Q+++ E ++ A + ++K E+E+ L+EK + E+L+R E +A + R +E Sbjct: 1960 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 2019 Query: 514 ALSHTEQSKSELSSRL--------DTLSAEKDALSGAVRQR---EADLLAAQSLVR---- 558 Q K+++ RL L +K + +RQR E ++LA ++ Sbjct: 2020 ---QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 2076 Query: 559 ---ETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAE 610 E E L R E S+EQ EL+ + + E+ R+R +E+ A E Sbjct: 2077 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2136 Query: 611 AAGILQDAV-------SKLDDPLHLRCTSSPDYL--VSRAQEALDAVSTLEEGHAQYLTS 661 AA + A+ +K+++ LR + + + AQEA A L+ + + Sbjct: 2137 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA--AQKRLQAEEKAHAFA 2194 Query: 662 LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECG-----ARALELM 716 + + + D + + A + + + RE E + Sbjct: 2195 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2254 Query: 717 GQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIED 776 Q ++QA QA L+ +E + ++ Q E A+ K+ A A +E Sbjct: 2255 KQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQ--AADAEMEK 2306 Query: 777 AVRRIEDMMNQARHASS-----GVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 831 + E + Q ++LE + N + ++ ++ T + + ++ E Sbjct: 2307 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2366 Query: 832 GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQ--LVEAADKVVLHTGKYEELIVCSHE 889 Q E +K E A TQ L E A+K+ + L V + E Sbjct: 2367 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2426 Query: 890 IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 949 AA QL A + A + + L+E + V E K+ E ++ + + Sbjct: 2427 -AARLRQL--AEEDLAQQRALAEKMLKEKMQAVQE-----ATRLKAEAELLQQQKELAQE 2478 Query: 950 GLSLIKLKKQEMETQV--RVLELEKTLEAERMRLGEL 984 ++ K++M Q+ ++TLEAER R E+ Sbjct: 2479 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2515 Score = 68.6 bits (166), Expect = 3e-11 Identities = 153/722 (21%), Positives = 289/722 (40%), Gaps = 104/722 (14%) Query: 336 IESLKREVEMLRSELEKIKLEAQRYI-AQLKSQVNALEGELEEQRK-------QKQKALV 387 +E L+ + E L + ++E R + L++ + E EL+ +R Q +++L Sbjct: 1675 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1734 Query: 388 DNE----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 443 + QLR E + Q E ER+ REEAER+ + + N+ + V + Sbjct: 1735 EEHVAVAQLREEAERRAQQQAEAERA---REEAERELERWQLKANEALRLRLQAEEVAQQ 1791 Query: 444 LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE------------------- 484 A+ KQ ++ + +EQ Q E ++E E Sbjct: 1792 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1851 Query: 485 -LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL--SG 541 ++L +++Q E+ ++ LE ELAR Q + Q + EL + L + AE + L S Sbjct: 1852 LIRLRAETEQGEQQRQLLEE---ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1908 Query: 542 AVRQREADLLAAQSLVR-ETEAALSRE------QQRSSQEQGELQGRLAERESQEQGLR- 593 A + E+ + +S R E EA RE + R+ E+ + Q +LAE ++ Q Sbjct: 1909 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1968 Query: 594 QRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEE 653 +R+L E+ A A EA + +A L + + + L A++ LEE Sbjct: 1969 ERVLAEKLA----AIGEATRLKTEAEIALKEK-----EAENERLRRLAEDEAFQRRRLEE 2019 Query: 654 GHAQYLTSLADASALV-----AALTRFSHLAADTIINGGATSH--LAPTDPADRLIDTCR 706 AQ+ + + A + + L R L DT+ LA ++ Sbjct: 2020 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK-----A 2074 Query: 707 ECGARALEL-MGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV 763 G LEL +G+++ + LR + + + Q L +E + + + R ++ A Sbjct: 2075 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2134 Query: 764 DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT--- 820 ++ AA+E+ V R++ + +AR + E ++ + K ++ Sbjct: 2135 EEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2193 Query: 821 ---------STSLQKE--IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEA 869 +LQ+E +++ RG A A+ + E + A + Q+ EA Sbjct: 2194 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE--EARVQAEREAAQSRRQVEEA 2251 Query: 870 ADKVVLHTGKYEELIVCSHEIAASTAQLVAAS---KVKANKHSPHLSRLQECSRTVNERA 926 E L + E A + AQ AA+ + +A + + ++ ++ + + A Sbjct: 2252 -----------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2300 Query: 927 ANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGELR 985 + K EQ + L+ ++L+ +E + Q +L+ E + L+AE R Sbjct: 2301 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2360 Query: 986 KQ 987 Q Sbjct: 2361 SQ 2362 Score = 66.2 bits (160), Expect = 1e-10 Identities = 90/330 (27%), Positives = 146/330 (44%), Gaps = 63/330 (19%) Query: 335 QIESLKREVEMLRSE----LEKIK--LEAQRYIAQLKSQVNA--------LEGELEEQRK 380 ++E +R E R+E L +++ LE QR +A+ +Q A L+ ++E+ Sbjct: 1480 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1539 Query: 381 QKQKALVDNEQ----LRHELAQLRA---AQLEGERSQGLREEAERKASATEARYNKLKEK 433 ++++A VD +Q ++ EL QLR A+++ + Q E R E R +L+ + Sbjct: 1540 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1599 Query: 434 HSELVHVHAE----LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEE 489 +E AE LR A+ A+ +Q+QEE R++ Q V+ ES+ K + Sbjct: 1600 ATERQRGGAEGELQALRARAEEAE--AQKRQAQEEAERLRRQ-------VQDESQRKRQA 1650 Query: 490 KSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKD-----ALSGAVR 544 + + ++K E EA A E RA +AL E RL E+ AL A R Sbjct: 1651 EVELASRVKAEAEA-AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1709 Query: 545 QREADLLAAQSLVRETEAALSR--------------EQQRSSQEQGELQGRLAERESQ-- 588 EA+L + ++ E A L R E +R +Q+Q E + E E + Sbjct: 1710 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1769 Query: 589 ------EQGLRQRLLDEQFAVLRG-AAAEA 611 + LR RL E+ A + A AEA Sbjct: 1770 RWQLKANEALRLRLQAEEVAQQKSLAQAEA 1799 Score = 65.9 bits (159), Expect = 2e-10 Identities = 151/729 (20%), Positives = 289/729 (39%), Gaps = 107/729 (14%) Query: 330 DDRDLQIESLKREVEMLRSELEKIKL---EAQRYIAQLKSQVNALEGELEEQRKQKQKAL 386 D R ++E L R++ R + + +A+R Q+++ A + EQ +Q+Q L Sbjct: 1333 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1392 Query: 387 VDNEQLRHELAQLRA--------------------AQLEGERSQGLREEAERKASATEAR 426 + E+ ++ + + AQLE S + + + + + Sbjct: 1393 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1452 Query: 427 YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ-SQEEVARVKEQLA---FQVEQVKRE 482 Y L+ +SEL + ++ ++ ++T +++ ++ ++++ A +E+LA +E+ ++ Sbjct: 1453 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1512 Query: 483 SELKLEEKSDQLEKLKRELEAK-AGELARAQEALSHTEQSKSELSSRLDTLSAEKDA-LS 540 +E + K+ Q E+ +EL+ + E+ R +EA +Q K + L L +A + Sbjct: 1513 AEAHAQAKA-QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1571 Query: 541 GAVRQREA---DLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA-------------- 583 RQ EA L + +R L +++ +GELQ A Sbjct: 1572 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1631 Query: 584 -----ERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL- 637 R+ Q++ R+R + + A A AEAA Q A+ L++ L L+ + L Sbjct: 1632 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-LRLQAEEAERRLR 1690 Query: 638 ---VSRAQEALDAVSTLEEGHAQYL----TSLADASALVAALTRFSHLAADTIINGGATS 690 V RA++ A+ T + L S A+ +A + + H+A + A Sbjct: 1691 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV-AQLREEAER 1749 Query: 691 HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPK 750 A+R RE R LE QL+ +ALR LQ + + K Sbjct: 1750 RAQQQAEAER----AREEAERELE-RWQLKANEALRLR------------LQAEEVAQQK 1792 Query: 751 SL-DVRQEELGAVVDKEMAATSAAIEDAVRRIE------DMMNQARHASSGVKLEVNERI 803 SL E+ ++E A E AVR+ E + Q ++ +L + + Sbjct: 1793 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1852 Query: 804 LNSCTDLMKA---IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLI-SASKAV 859 + + + +LL LQ+E + + + AK E L+ S ++A Sbjct: 1853 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1912 Query: 860 GWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECS 919 + ++ ++ G++ EL + E A A A + + + E Sbjct: 1913 EESRSTSEKSKQRLEAEAGRFREL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1969 Query: 920 RTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM 979 R + E+ A + +T+ E + I LK++E E + R+ L + +R Sbjct: 1970 RVLAEKLAAIGEATRLKTE-------------AEIALKEKEAENE-RLRRLAEDEAFQRR 2015 Query: 980 RLGELRKQH 988 RL E QH Sbjct: 2016 RLEEQAAQH 2024 Score = 62.4 bits (150), Expect = 2e-09 Identities = 94/410 (22%), Positives = 167/410 (40%), Gaps = 41/410 (10%) Query: 332 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 391 R L E L ++ L ++ K K++A + +LK++ L+ + E ++Q ++ D EQ Sbjct: 2431 RQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2489 Query: 392 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE----LLRK 447 + +LA + +G + E + + EA KL+ AE RK Sbjct: 2490 MAQQLA----EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2545 Query: 448 NA-DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKREL--EAK 504 A + ++L T+ + +E + + L Q +Q ++E +L E +LE+ K +L EAK Sbjct: 2546 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAK 2604 Query: 505 AGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA-- 562 +L + EQ E + + +EKD+L R E + + L ++ A Sbjct: 2605 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2664 Query: 563 -ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSK 621 L EQQR Q+ + + RL S E+ R+ + A E Q+ + + Sbjct: 2665 QQLREEQQRQQQQMEQERQRLV--ASMEEARRR----------QHEAEEGVRRKQEELQQ 2712 Query: 622 LDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAAD 681 L+ + + L Q + + LEE H L + +A A T+ Sbjct: 2713 LEQ----QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK------- 2761 Query: 682 TIING--GATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQ 729 T+ NG A +P R+ A+ L+ G L ++ R Q Sbjct: 2762 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2811 Score = 49.3 bits (116), Expect = 2e-05 Identities = 151/706 (21%), Positives = 265/706 (37%), Gaps = 78/706 (11%) Query: 334 LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 393 L I + E+LR+ E++K EAQ A L ++ A + L++ R Q + + LR Sbjct: 1230 LVIRGTQGAEEVLRAHEEQLK-EAQAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALR 1287 Query: 394 HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 453 EL R AQ GER Q E + + R +L E+ ++ R+ + Sbjct: 1288 DEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1344 Query: 454 QLTVTQQSQEEVARVKEQLAFQVEQVKR---ESELKLEEKSDQLEKLKRELEAKAGELAR 510 QL ++S + + + + EQ++ + E+ Q + L E+E ++ Sbjct: 1345 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1404 Query: 511 AQEALSHTEQSKSELSSRLDTLSAEKDAL------------SGAVRQREADL-------- 550 Q + + +L T A+ + + S +V Q DL Sbjct: 1405 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1464 Query: 551 -LAAQ--SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA 607 L +Q + ET + E++ + Q++ E + RLAE E+ + +QR L E A + Sbjct: 1465 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE--KQRQLAEAHAQAKAQ 1522 Query: 608 AAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA 667 A A LQ ++ + + R ++ D + + + A+ A A Sbjct: 1523 AEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1579 Query: 668 LVAALTRFS--------HLAADTIINGGATSHL-APTDPADRLIDTCRECGARALELMGQ 718 + R L A GGA L A A+ R+ A L Q Sbjct: 1580 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1639 Query: 719 LQDQQALRHMQ----ASLVRTPL------QGILQLGQELKPKSLDVRQEELGAVVDKEMA 768 +QD+ + AS V+ Q LQ +EL+ ++ + + A V++ Sbjct: 1640 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER-AR 1698 Query: 769 ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 828 A+E A R E + Q++ AS K ER L + +R Q E Sbjct: 1699 QVQVALETAQRSAEAEL-QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1757 Query: 829 VESGRGAATQQEFY------AKNSRWTEGLISASKAVGWG-ATQLVEAADKVVLHTGKYE 881 + A + E + A R ++ K++ A + E A++ GK E Sbjct: 1758 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1817 Query: 882 ELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ-- 939 E V E+A +L ++ L+ QE R + A T+ G++Q Sbjct: 1818 EQAVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIR--------LRAETEQGEQQRQ 1867 Query: 940 -IEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGE 983 +E+ + K+QE+E ++ + E + L A + R E Sbjct: 1868 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1913 Score = 45.1 bits (105), Expect = 4e-04 Identities = 136/688 (19%), Positives = 264/688 (38%), Gaps = 67/688 (9%) Query: 337 ESLKREVEMLRS----ELEKIKLEAQR---YIAQLKSQVNALEGELEEQRKQKQKALVDN 389 +SL+R+V+++RS +K E QR + +L Q + + + + + + Sbjct: 1034 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 1093 Query: 390 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 449 E + QL QG +EE+ + +E + +L+ + E VH L + Sbjct: 1094 E---YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1150 Query: 450 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--LKLEEKSDQLEKLKRELEAKAGE 507 + A++ Q++ E L V ++ E+E L L E S L+ ELE G+ Sbjct: 1151 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1210 Query: 508 LARAQE--------------ALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA 553 L + + + T+ ++ L + + L E A+ + + EA + Sbjct: 1211 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASL 1269 Query: 554 QSLVRETEAA-----LSREQQRSSQEQGE-LQGRLAERESQEQGLRQR---LLDEQFAVL 604 + L + EA R++ R +QE GE LQ R ER+ + + R+R LL+ AVL Sbjct: 1270 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1329 Query: 605 -----RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYL 659 R E G + DPL + R QE + A+ + + Sbjct: 1330 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA-----RRRQEQIQAMPLADSQAVR-- 1382 Query: 660 TSLADASALVAALTRFSHLA------ADTIINGGATSHLAPTDPADRLIDTCRECGARAL 713 L AL+ + R A IN L +L + Sbjct: 1383 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1442 Query: 714 ELMGQ--LQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 771 + + +Q+ LR + L Q I + + L+ + R E ++E A Sbjct: 1443 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1502 Query: 772 AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 831 A + R++ + QA+ + E+ +R+ +A S+Q+E+ + Sbjct: 1503 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1562 Query: 832 GRGAATQQEFYAKNSRWTE-GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEI 890 + + + + A+ + E + + + QL EA ++ G EL + Sbjct: 1563 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATER--QRGGAEGEL-----QA 1614 Query: 891 AASTAQLVAASKVKANKHSPHLSR-LQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 949 + A+ A K +A + + L R +Q+ S+ + + + K+ E ++ Sbjct: 1615 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-LQ 1673 Query: 950 GLSLIKLKKQEMETQVRVLELEKTLEAE 977 L ++L+ +E E ++R E+E+ + + Sbjct: 1674 ALEELRLQAEEAERRLRQAEVERARQVQ 1701 >gi|41322908 plectin 1 isoform 3 [Homo sapiens] Length = 4525 Score = 79.0 bits (193), Expect = 2e-14 Identities = 170/688 (24%), Positives = 284/688 (41%), Gaps = 102/688 (14%) Query: 334 LQIESLKR-------EVEMLRS---ELEKIKLEAQRYIAQLKSQV-----NALEGELE-- 376 LQ+E+ +R E++ LR+ E E K +AQ +L+ QV + E+E Sbjct: 1437 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1496 Query: 377 -------EQRKQKQKALVDNEQLR--HELAQLRAAQLEGERSQGLREEAERKASATEARY 427 E ++KQ+AL E+LR E A+ R Q E ER++ ++ E + EA Sbjct: 1497 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-- 1554 Query: 428 NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 487 +L+ K + A+L R + + + V Q +E R ++Q + E+ + E+E +L Sbjct: 1555 -ELQSKRASFAEKTAQLERSLQE--EHVAVAQLREEAERRAQQQA--EAERAREEAEREL 1609 Query: 488 EE---KSDQLEKLKRELEAKAGELARAQ-EALSHTEQSKSELSSRLDTLSAEKDALSGAV 543 E K+++ +L+ + E A + + AQ EA E+++ E R A AV Sbjct: 1610 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAV 1662 Query: 544 RQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 603 RQRE LA Q L ++ + A QQR + EQ EL AE E EQ +++LL+E+ A Sbjct: 1663 RQRE---LAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQ--QRQLLEEELAR 1716 Query: 604 LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA 663 L+ AA A Q+ L+ L L S+A+ ++ ST E+ + Sbjct: 1717 LQREAAAATQKRQE----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR------ 1766 Query: 664 DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 723 L A RF LA + A A + A R E AR Q + Sbjct: 1767 ----LEAEAGRFRELAEE------AARLRALAEEAKRQRQLAEEDAAR--------QRAE 1808 Query: 724 ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR--- 780 A R + L L+ E+ K + E L + + E E A + Sbjct: 1809 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1868 Query: 781 IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG-AATQQ 839 IE+ + Q R AS +LE + ++ D ++ R + +L+ ++ G A + Sbjct: 1869 IEERLAQLRKASDS-ELERQKGLVE---DTLRQRRQVEEEILALKASFEKAAAGKAELEL 1924 Query: 840 EFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEEL--IVCSHEIAASTAQL 897 E S + L S +A A Q AA++ E + + + E AA + Sbjct: 1925 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1984 Query: 898 VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLK 957 + RL+E R E A + + ++ Q++++ + K Sbjct: 1985 ALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEE------------K 2030 Query: 958 KQEMETQVRVLELEKTLEAERMRLGELR 985 Q + EL++TL+ E+ L +LR Sbjct: 2031 AHAFAVQQKEQELQQTLQQEQSVLDQLR 2058 Score = 77.8 bits (190), Expect = 5e-14 Identities = 158/768 (20%), Positives = 296/768 (38%), Gaps = 96/768 (12%) Query: 330 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 389 +D Q ++ E+ L++ EK A A+L+ ++ + E+ + K++A ++ Sbjct: 1892 EDTLRQRRQVEEEILALKASFEK----AAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1947 Query: 390 EQLRHELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 445 + R A+ + E E +S EEA R+ A +LK K E A L Sbjct: 1948 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRL 2002 Query: 446 RKNAD--TAKQLTVTQQSQEEVARVKEQL-AFQVEQVKRESELKLEEKSDQLEKLKRELE 502 R+ A+ +A+QL + Q++ ++ + +E+ AF V+Q ++E + L+++ L++L+ E E Sbjct: 2003 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2062 Query: 503 AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 562 A A+EA E+ ++ +++ K + + R AA+ L +E E Sbjct: 2063 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2122 Query: 563 ALSREQQRSSQEQGELQGRLAERESQ----EQGLRQR----------------------L 596 +R Q + Q AE E EQ LRQ+ L Sbjct: 2123 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2182 Query: 597 LDEQFAVLRGAAAEAAGILQDAVSKLD---------DPLHLRCTSSPDYLVSRAQEALDA 647 LDE+ L+ A EAA +L L R + L+ R ++ Sbjct: 2183 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2242 Query: 648 VSTLE-EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 706 E E Q A S R LA + + A + + + + R Sbjct: 2243 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2302 Query: 707 -ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELK--PKSLDV---RQEELG 760 + A L+ +L +QA R L Q QL +E + ++L+ RQ E+ Sbjct: 2303 LKAEAELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2357 Query: 761 AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 820 A ++ + R ED + A E+ E++ T+L ++ + Sbjct: 2358 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR--TELATQEKVTLVQ 2410 Query: 821 STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLH---- 876 + +Q++ +S A +E A+ R E L +K + + ++ + +L Sbjct: 2411 TLEIQRQ--QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2468 Query: 877 -----TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVA 931 + + L+ I A+L + + K Q + + + +VA Sbjct: 2469 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2528 Query: 932 STKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGE----LRKQ 987 S + + + + + G+ + + Q++E Q R + E+ L E RL E L +Q Sbjct: 2529 SMEEARRRQHEAE----EGVRRKQEELQQLEQQRR--QQEELLAEENQRLREQLQLLEEQ 2582 Query: 988 HYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLD 1035 H A+ + EEV A +++ + L P+ +H D Sbjct: 2583 H----RAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEPEHSFD 2625 Score = 73.9 bits (180), Expect = 7e-13 Identities = 151/697 (21%), Positives = 281/697 (40%), Gaps = 81/697 (11%) Query: 344 EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA-- 401 + L +E E I+L A+ Q + Q LE EL +++ A ++L ELA++RA Sbjct: 1685 QRLAAEQELIRLRAET--EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1742 Query: 402 -------AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 454 A+ E E S+ E+++++ A R+ +L E+ + L AE ++ A++ Sbjct: 1743 EVLLASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARL-RALAEEAKRQRQLAEE 1800 Query: 455 LTVTQQSQEEVARVKEQLAF-QVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQE 513 Q+++ E ++ A + ++K E+E+ L+EK + E+L+R E +A + R +E Sbjct: 1801 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1860 Query: 514 ALSHTEQSKSELSSRL--------DTLSAEKDALSGAVRQR---EADLLAAQSLVR---- 558 Q K+++ RL L +K + +RQR E ++LA ++ Sbjct: 1861 ---QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1917 Query: 559 ---ETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAE 610 E E L R E S+EQ EL+ + + E+ R+R +E+ A E Sbjct: 1918 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1977 Query: 611 AAGILQDAV-------SKLDDPLHLRCTSSPDYL--VSRAQEALDAVSTLEEGHAQYLTS 661 AA + A+ +K+++ LR + + + AQEA A L+ + + Sbjct: 1978 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA--AQKRLQAEEKAHAFA 2035 Query: 662 LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECG-----ARALELM 716 + + + D + + A + + + RE E + Sbjct: 2036 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2095 Query: 717 GQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIED 776 Q ++QA QA L+ +E + ++ Q E A+ K+ A A +E Sbjct: 2096 KQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQ--AADAEMEK 2147 Query: 777 AVRRIEDMMNQARHASS-----GVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 831 + E + Q ++LE + N + ++ ++ T + + ++ E Sbjct: 2148 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2207 Query: 832 GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQ--LVEAADKVVLHTGKYEELIVCSHE 889 Q E +K E A TQ L E A+K+ + L V + E Sbjct: 2208 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2267 Query: 890 IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 949 AA QL A + A + + L+E + V E K+ E ++ + + Sbjct: 2268 -AARLRQL--AEEDLAQQRALAEKMLKEKMQAVQE-----ATRLKAEAELLQQQKELAQE 2319 Query: 950 GLSLIKLKKQEMETQV--RVLELEKTLEAERMRLGEL 984 ++ K++M Q+ ++TLEAER R E+ Sbjct: 2320 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2356 Score = 68.6 bits (166), Expect = 3e-11 Identities = 153/722 (21%), Positives = 289/722 (40%), Gaps = 104/722 (14%) Query: 336 IESLKREVEMLRSELEKIKLEAQRYI-AQLKSQVNALEGELEEQRK-------QKQKALV 387 +E L+ + E L + ++E R + L++ + E EL+ +R Q +++L Sbjct: 1516 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1575 Query: 388 DNE----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 443 + QLR E + Q E ER+ REEAER+ + + N+ + V + Sbjct: 1576 EEHVAVAQLREEAERRAQQQAEAERA---REEAERELERWQLKANEALRLRLQAEEVAQQ 1632 Query: 444 LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE------------------- 484 A+ KQ ++ + +EQ Q E ++E E Sbjct: 1633 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1692 Query: 485 -LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL--SG 541 ++L +++Q E+ ++ LE ELAR Q + Q + EL + L + AE + L S Sbjct: 1693 LIRLRAETEQGEQQRQLLEE---ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1749 Query: 542 AVRQREADLLAAQSLVR-ETEAALSRE------QQRSSQEQGELQGRLAERESQEQGLR- 593 A + E+ + +S R E EA RE + R+ E+ + Q +LAE ++ Q Sbjct: 1750 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1809 Query: 594 QRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEE 653 +R+L E+ A A EA + +A L + + + L A++ LEE Sbjct: 1810 ERVLAEKLA----AIGEATRLKTEAEIALKEK-----EAENERLRRLAEDEAFQRRRLEE 1860 Query: 654 GHAQYLTSLADASALV-----AALTRFSHLAADTIINGGATSH--LAPTDPADRLIDTCR 706 AQ+ + + A + + L R L DT+ LA ++ Sbjct: 1861 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK-----A 1915 Query: 707 ECGARALEL-MGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV 763 G LEL +G+++ + LR + + + Q L +E + + + R ++ A Sbjct: 1916 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1975 Query: 764 DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT--- 820 ++ AA+E+ V R++ + +AR + E ++ + K ++ Sbjct: 1976 EEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2034 Query: 821 ---------STSLQKE--IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEA 869 +LQ+E +++ RG A A+ + E + A + Q+ EA Sbjct: 2035 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE--EARVQAEREAAQSRRQVEEA 2092 Query: 870 ADKVVLHTGKYEELIVCSHEIAASTAQLVAAS---KVKANKHSPHLSRLQECSRTVNERA 926 E L + E A + AQ AA+ + +A + + ++ ++ + + A Sbjct: 2093 -----------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2141 Query: 927 ANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGELR 985 + K EQ + L+ ++L+ +E + Q +L+ E + L+AE R Sbjct: 2142 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2201 Query: 986 KQ 987 Q Sbjct: 2202 SQ 2203 Score = 66.2 bits (160), Expect = 1e-10 Identities = 90/330 (27%), Positives = 146/330 (44%), Gaps = 63/330 (19%) Query: 335 QIESLKREVEMLRSE----LEKIK--LEAQRYIAQLKSQVNA--------LEGELEEQRK 380 ++E +R E R+E L +++ LE QR +A+ +Q A L+ ++E+ Sbjct: 1321 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1380 Query: 381 QKQKALVDNEQ----LRHELAQLRA---AQLEGERSQGLREEAERKASATEARYNKLKEK 433 ++++A VD +Q ++ EL QLR A+++ + Q E R E R +L+ + Sbjct: 1381 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1440 Query: 434 HSELVHVHAE----LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEE 489 +E AE LR A+ A+ +Q+QEE R++ Q V+ ES+ K + Sbjct: 1441 ATERQRGGAEGELQALRARAEEAE--AQKRQAQEEAERLRRQ-------VQDESQRKRQA 1491 Query: 490 KSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKD-----ALSGAVR 544 + + ++K E EA A E RA +AL E RL E+ AL A R Sbjct: 1492 EVELASRVKAEAEA-AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1550 Query: 545 QREADLLAAQSLVRETEAALSR--------------EQQRSSQEQGELQGRLAERESQ-- 588 EA+L + ++ E A L R E +R +Q+Q E + E E + Sbjct: 1551 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1610 Query: 589 ------EQGLRQRLLDEQFAVLRG-AAAEA 611 + LR RL E+ A + A AEA Sbjct: 1611 RWQLKANEALRLRLQAEEVAQQKSLAQAEA 1640 Score = 65.9 bits (159), Expect = 2e-10 Identities = 151/729 (20%), Positives = 289/729 (39%), Gaps = 107/729 (14%) Query: 330 DDRDLQIESLKREVEMLRSELEKIKL---EAQRYIAQLKSQVNALEGELEEQRKQKQKAL 386 D R ++E L R++ R + + +A+R Q+++ A + EQ +Q+Q L Sbjct: 1174 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1233 Query: 387 VDNEQLRHELAQLRA--------------------AQLEGERSQGLREEAERKASATEAR 426 + E+ ++ + + AQLE S + + + + + Sbjct: 1234 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1293 Query: 427 YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ-SQEEVARVKEQLA---FQVEQVKRE 482 Y L+ +SEL + ++ ++ ++T +++ ++ ++++ A +E+LA +E+ ++ Sbjct: 1294 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1353 Query: 483 SELKLEEKSDQLEKLKRELEAK-AGELARAQEALSHTEQSKSELSSRLDTLSAEKDA-LS 540 +E + K+ Q E+ +EL+ + E+ R +EA +Q K + L L +A + Sbjct: 1354 AEAHAQAKA-QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1412 Query: 541 GAVRQREA---DLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA-------------- 583 RQ EA L + +R L +++ +GELQ A Sbjct: 1413 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1472 Query: 584 -----ERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL- 637 R+ Q++ R+R + + A A AEAA Q A+ L++ L L+ + L Sbjct: 1473 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-LRLQAEEAERRLR 1531 Query: 638 ---VSRAQEALDAVSTLEEGHAQYL----TSLADASALVAALTRFSHLAADTIINGGATS 690 V RA++ A+ T + L S A+ +A + + H+A + A Sbjct: 1532 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV-AQLREEAER 1590 Query: 691 HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPK 750 A+R RE R LE QL+ +ALR LQ + + K Sbjct: 1591 RAQQQAEAER----AREEAERELE-RWQLKANEALRLR------------LQAEEVAQQK 1633 Query: 751 SL-DVRQEELGAVVDKEMAATSAAIEDAVRRIE------DMMNQARHASSGVKLEVNERI 803 SL E+ ++E A E AVR+ E + Q ++ +L + + Sbjct: 1634 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1693 Query: 804 LNSCTDLMKA---IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLI-SASKAV 859 + + + +LL LQ+E + + + AK E L+ S ++A Sbjct: 1694 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1753 Query: 860 GWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECS 919 + ++ ++ G++ EL + E A A A + + + E Sbjct: 1754 EESRSTSEKSKQRLEAEAGRFREL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1810 Query: 920 RTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM 979 R + E+ A + +T+ E + I LK++E E + R+ L + +R Sbjct: 1811 RVLAEKLAAIGEATRLKTE-------------AEIALKEKEAENE-RLRRLAEDEAFQRR 1856 Query: 980 RLGELRKQH 988 RL E QH Sbjct: 1857 RLEEQAAQH 1865 Score = 62.4 bits (150), Expect = 2e-09 Identities = 94/410 (22%), Positives = 167/410 (40%), Gaps = 41/410 (10%) Query: 332 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 391 R L E L ++ L ++ K K++A + +LK++ L+ + E ++Q ++ D EQ Sbjct: 2272 RQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2330 Query: 392 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE----LLRK 447 + +LA + +G + E + + EA KL+ AE RK Sbjct: 2331 MAQQLA----EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2386 Query: 448 NA-DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKREL--EAK 504 A + ++L T+ + +E + + L Q +Q ++E +L E +LE+ K +L EAK Sbjct: 2387 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAK 2445 Query: 505 AGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA-- 562 +L + EQ E + + +EKD+L R E + + L ++ A Sbjct: 2446 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2505 Query: 563 -ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSK 621 L EQQR Q+ + + RL S E+ R+ + A E Q+ + + Sbjct: 2506 QQLREEQQRQQQQMEQERQRLV--ASMEEARRR----------QHEAEEGVRRKQEELQQ 2553 Query: 622 LDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAAD 681 L+ + + L Q + + LEE H L + +A A T+ Sbjct: 2554 LEQ----QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK------- 2602 Query: 682 TIING--GATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQ 729 T+ NG A +P R+ A+ L+ G L ++ R Q Sbjct: 2603 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2652 Score = 49.3 bits (116), Expect = 2e-05 Identities = 151/706 (21%), Positives = 265/706 (37%), Gaps = 78/706 (11%) Query: 334 LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 393 L I + E+LR+ E++K EAQ A L ++ A + L++ R Q + + LR Sbjct: 1071 LVIRGTQGAEEVLRAHEEQLK-EAQAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALR 1128 Query: 394 HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 453 EL R AQ GER Q E + + R +L E+ ++ R+ + Sbjct: 1129 DEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1185 Query: 454 QLTVTQQSQEEVARVKEQLAFQVEQVKR---ESELKLEEKSDQLEKLKRELEAKAGELAR 510 QL ++S + + + + EQ++ + E+ Q + L E+E ++ Sbjct: 1186 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1245 Query: 511 AQEALSHTEQSKSELSSRLDTLSAEKDAL------------SGAVRQREADL-------- 550 Q + + +L T A+ + + S +V Q DL Sbjct: 1246 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1305 Query: 551 -LAAQ--SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA 607 L +Q + ET + E++ + Q++ E + RLAE E+ + +QR L E A + Sbjct: 1306 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE--KQRQLAEAHAQAKAQ 1363 Query: 608 AAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA 667 A A LQ ++ + + R ++ D + + + A+ A A Sbjct: 1364 AEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1420 Query: 668 LVAALTRFS--------HLAADTIINGGATSHL-APTDPADRLIDTCRECGARALELMGQ 718 + R L A GGA L A A+ R+ A L Q Sbjct: 1421 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1480 Query: 719 LQDQQALRHMQ----ASLVRTPL------QGILQLGQELKPKSLDVRQEELGAVVDKEMA 768 +QD+ + AS V+ Q LQ +EL+ ++ + + A V++ Sbjct: 1481 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER-AR 1539 Query: 769 ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 828 A+E A R E + Q++ AS K ER L + +R Q E Sbjct: 1540 QVQVALETAQRSAEAEL-QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1598 Query: 829 VESGRGAATQQEFY------AKNSRWTEGLISASKAVGWG-ATQLVEAADKVVLHTGKYE 881 + A + E + A R ++ K++ A + E A++ GK E Sbjct: 1599 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1658 Query: 882 ELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ-- 939 E V E+A +L ++ L+ QE R + A T+ G++Q Sbjct: 1659 EQAVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIR--------LRAETEQGEQQRQ 1708 Query: 940 -IEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGE 983 +E+ + K+QE+E ++ + E + L A + R E Sbjct: 1709 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1754 Score = 45.1 bits (105), Expect = 4e-04 Identities = 136/688 (19%), Positives = 264/688 (38%), Gaps = 67/688 (9%) Query: 337 ESLKREVEMLRS----ELEKIKLEAQR---YIAQLKSQVNALEGELEEQRKQKQKALVDN 389 +SL+R+V+++RS +K E QR + +L Q + + + + + + Sbjct: 875 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 934 Query: 390 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 449 E + QL QG +EE+ + +E + +L+ + E VH L + Sbjct: 935 E---YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 991 Query: 450 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--LKLEEKSDQLEKLKRELEAKAGE 507 + A++ Q++ E L V ++ E+E L L E S L+ ELE G+ Sbjct: 992 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1051 Query: 508 LARAQE--------------ALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA 553 L + + + T+ ++ L + + L E A+ + + EA + Sbjct: 1052 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASL 1110 Query: 554 QSLVRETEAA-----LSREQQRSSQEQGE-LQGRLAERESQEQGLRQR---LLDEQFAVL 604 + L + EA R++ R +QE GE LQ R ER+ + + R+R LL+ AVL Sbjct: 1111 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1170 Query: 605 -----RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYL 659 R E G + DPL + R QE + A+ + + Sbjct: 1171 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA-----RRRQEQIQAMPLADSQAVR-- 1223 Query: 660 TSLADASALVAALTRFSHLA------ADTIINGGATSHLAPTDPADRLIDTCRECGARAL 713 L AL+ + R A IN L +L + Sbjct: 1224 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1283 Query: 714 ELMGQ--LQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 771 + + +Q+ LR + L Q I + + L+ + R E ++E A Sbjct: 1284 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1343 Query: 772 AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 831 A + R++ + QA+ + E+ +R+ +A S+Q+E+ + Sbjct: 1344 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1403 Query: 832 GRGAATQQEFYAKNSRWTE-GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEI 890 + + + + A+ + E + + + QL EA ++ G EL + Sbjct: 1404 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATER--QRGGAEGEL-----QA 1455 Query: 891 AASTAQLVAASKVKANKHSPHLSR-LQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 949 + A+ A K +A + + L R +Q+ S+ + + + K+ E ++ Sbjct: 1456 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-LQ 1514 Query: 950 GLSLIKLKKQEMETQVRVLELEKTLEAE 977 L ++L+ +E E ++R E+E+ + + Sbjct: 1515 ALEELRLQAEEAERRLRQAEVERARQVQ 1542 >gi|41322912 plectin 1 isoform 2 [Homo sapiens] Length = 4533 Score = 79.0 bits (193), Expect = 2e-14 Identities = 170/688 (24%), Positives = 284/688 (41%), Gaps = 102/688 (14%) Query: 334 LQIESLKR-------EVEMLRS---ELEKIKLEAQRYIAQLKSQV-----NALEGELE-- 376 LQ+E+ +R E++ LR+ E E K +AQ +L+ QV + E+E Sbjct: 1445 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1504 Query: 377 -------EQRKQKQKALVDNEQLR--HELAQLRAAQLEGERSQGLREEAERKASATEARY 427 E ++KQ+AL E+LR E A+ R Q E ER++ ++ E + EA Sbjct: 1505 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-- 1562 Query: 428 NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 487 +L+ K + A+L R + + + V Q +E R ++Q + E+ + E+E +L Sbjct: 1563 -ELQSKRASFAEKTAQLERSLQE--EHVAVAQLREEAERRAQQQA--EAERAREEAEREL 1617 Query: 488 EE---KSDQLEKLKRELEAKAGELARAQ-EALSHTEQSKSELSSRLDTLSAEKDALSGAV 543 E K+++ +L+ + E A + + AQ EA E+++ E R A AV Sbjct: 1618 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAV 1670 Query: 544 RQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 603 RQRE LA Q L ++ + A QQR + EQ EL AE E EQ +++LL+E+ A Sbjct: 1671 RQRE---LAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQ--QRQLLEEELAR 1724 Query: 604 LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA 663 L+ AA A Q+ L+ L L S+A+ ++ ST E+ + Sbjct: 1725 LQREAAAATQKRQE----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR------ 1774 Query: 664 DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 723 L A RF LA + A A + A R E AR Q + Sbjct: 1775 ----LEAEAGRFRELAEE------AARLRALAEEAKRQRQLAEEDAAR--------QRAE 1816 Query: 724 ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR--- 780 A R + L L+ E+ K + E L + + E E A + Sbjct: 1817 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1876 Query: 781 IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG-AATQQ 839 IE+ + Q R AS +LE + ++ D ++ R + +L+ ++ G A + Sbjct: 1877 IEERLAQLRKASDS-ELERQKGLVE---DTLRQRRQVEEEILALKASFEKAAAGKAELEL 1932 Query: 840 EFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEEL--IVCSHEIAASTAQL 897 E S + L S +A A Q AA++ E + + + E AA + Sbjct: 1933 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1992 Query: 898 VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLK 957 + RL+E R E A + + ++ Q++++ + K Sbjct: 1993 ALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEE------------K 2038 Query: 958 KQEMETQVRVLELEKTLEAERMRLGELR 985 Q + EL++TL+ E+ L +LR Sbjct: 2039 AHAFAVQQKEQELQQTLQQEQSVLDQLR 2066 Score = 77.8 bits (190), Expect = 5e-14 Identities = 158/768 (20%), Positives = 296/768 (38%), Gaps = 96/768 (12%) Query: 330 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 389 +D Q ++ E+ L++ EK A A+L+ ++ + E+ + K++A ++ Sbjct: 1900 EDTLRQRRQVEEEILALKASFEK----AAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1955 Query: 390 EQLRHELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 445 + R A+ + E E +S EEA R+ A +LK K E A L Sbjct: 1956 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRL 2010 Query: 446 RKNAD--TAKQLTVTQQSQEEVARVKEQL-AFQVEQVKRESELKLEEKSDQLEKLKRELE 502 R+ A+ +A+QL + Q++ ++ + +E+ AF V+Q ++E + L+++ L++L+ E E Sbjct: 2011 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2070 Query: 503 AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 562 A A+EA E+ ++ +++ K + + R AA+ L +E E Sbjct: 2071 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2130 Query: 563 ALSREQQRSSQEQGELQGRLAERESQ----EQGLRQR----------------------L 596 +R Q + Q AE E EQ LRQ+ L Sbjct: 2131 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2190 Query: 597 LDEQFAVLRGAAAEAAGILQDAVSKLD---------DPLHLRCTSSPDYLVSRAQEALDA 647 LDE+ L+ A EAA +L L R + L+ R ++ Sbjct: 2191 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2250 Query: 648 VSTLE-EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 706 E E Q A S R LA + + A + + + + R Sbjct: 2251 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2310 Query: 707 -ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELK--PKSLDV---RQEELG 760 + A L+ +L +QA R L Q QL +E + ++L+ RQ E+ Sbjct: 2311 LKAEAELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2365 Query: 761 AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 820 A ++ + R ED + A E+ E++ T+L ++ + Sbjct: 2366 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR--TELATQEKVTLVQ 2418 Query: 821 STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLH---- 876 + +Q++ +S A +E A+ R E L +K + + ++ + +L Sbjct: 2419 TLEIQRQ--QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2476 Query: 877 -----TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVA 931 + + L+ I A+L + + K Q + + + +VA Sbjct: 2477 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2536 Query: 932 STKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGE----LRKQ 987 S + + + + + G+ + + Q++E Q R + E+ L E RL E L +Q Sbjct: 2537 SMEEARRRQHEAE----EGVRRKQEELQQLEQQRR--QQEELLAEENQRLREQLQLLEEQ 2590 Query: 988 HYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLD 1035 H A+ + EEV A +++ + L P+ +H D Sbjct: 2591 H----RAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEPEHSFD 2633 Score = 73.9 bits (180), Expect = 7e-13 Identities = 151/697 (21%), Positives = 281/697 (40%), Gaps = 81/697 (11%) Query: 344 EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA-- 401 + L +E E I+L A+ Q + Q LE EL +++ A ++L ELA++RA Sbjct: 1693 QRLAAEQELIRLRAET--EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1750 Query: 402 -------AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 454 A+ E E S+ E+++++ A R+ +L E+ + L AE ++ A++ Sbjct: 1751 EVLLASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARL-RALAEEAKRQRQLAEE 1808 Query: 455 LTVTQQSQEEVARVKEQLAF-QVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQE 513 Q+++ E ++ A + ++K E+E+ L+EK + E+L+R E +A + R +E Sbjct: 1809 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1868 Query: 514 ALSHTEQSKSELSSRL--------DTLSAEKDALSGAVRQR---EADLLAAQSLVR---- 558 Q K+++ RL L +K + +RQR E ++LA ++ Sbjct: 1869 ---QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1925 Query: 559 ---ETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAE 610 E E L R E S+EQ EL+ + + E+ R+R +E+ A E Sbjct: 1926 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1985 Query: 611 AAGILQDAV-------SKLDDPLHLRCTSSPDYL--VSRAQEALDAVSTLEEGHAQYLTS 661 AA + A+ +K+++ LR + + + AQEA A L+ + + Sbjct: 1986 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA--AQKRLQAEEKAHAFA 2043 Query: 662 LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECG-----ARALELM 716 + + + D + + A + + + RE E + Sbjct: 2044 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2103 Query: 717 GQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIED 776 Q ++QA QA L+ +E + ++ Q E A+ K+ A A +E Sbjct: 2104 KQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQ--AADAEMEK 2155 Query: 777 AVRRIEDMMNQARHASS-----GVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 831 + E + Q ++LE + N + ++ ++ T + + ++ E Sbjct: 2156 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2215 Query: 832 GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQ--LVEAADKVVLHTGKYEELIVCSHE 889 Q E +K E A TQ L E A+K+ + L V + E Sbjct: 2216 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2275 Query: 890 IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 949 AA QL A + A + + L+E + V E K+ E ++ + + Sbjct: 2276 -AARLRQL--AEEDLAQQRALAEKMLKEKMQAVQE-----ATRLKAEAELLQQQKELAQE 2327 Query: 950 GLSLIKLKKQEMETQV--RVLELEKTLEAERMRLGEL 984 ++ K++M Q+ ++TLEAER R E+ Sbjct: 2328 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2364 Score = 68.6 bits (166), Expect = 3e-11 Identities = 153/722 (21%), Positives = 289/722 (40%), Gaps = 104/722 (14%) Query: 336 IESLKREVEMLRSELEKIKLEAQRYI-AQLKSQVNALEGELEEQRK-------QKQKALV 387 +E L+ + E L + ++E R + L++ + E EL+ +R Q +++L Sbjct: 1524 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1583 Query: 388 DNE----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 443 + QLR E + Q E ER+ REEAER+ + + N+ + V + Sbjct: 1584 EEHVAVAQLREEAERRAQQQAEAERA---REEAERELERWQLKANEALRLRLQAEEVAQQ 1640 Query: 444 LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE------------------- 484 A+ KQ ++ + +EQ Q E ++E E Sbjct: 1641 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1700 Query: 485 -LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL--SG 541 ++L +++Q E+ ++ LE ELAR Q + Q + EL + L + AE + L S Sbjct: 1701 LIRLRAETEQGEQQRQLLEE---ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1757 Query: 542 AVRQREADLLAAQSLVR-ETEAALSRE------QQRSSQEQGELQGRLAERESQEQGLR- 593 A + E+ + +S R E EA RE + R+ E+ + Q +LAE ++ Q Sbjct: 1758 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1817 Query: 594 QRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEE 653 +R+L E+ A A EA + +A L + + + L A++ LEE Sbjct: 1818 ERVLAEKLA----AIGEATRLKTEAEIALKEK-----EAENERLRRLAEDEAFQRRRLEE 1868 Query: 654 GHAQYLTSLADASALV-----AALTRFSHLAADTIINGGATSH--LAPTDPADRLIDTCR 706 AQ+ + + A + + L R L DT+ LA ++ Sbjct: 1869 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK-----A 1923 Query: 707 ECGARALEL-MGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV 763 G LEL +G+++ + LR + + + Q L +E + + + R ++ A Sbjct: 1924 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1983 Query: 764 DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT--- 820 ++ AA+E+ V R++ + +AR + E ++ + K ++ Sbjct: 1984 EEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2042 Query: 821 ---------STSLQKE--IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEA 869 +LQ+E +++ RG A A+ + E + A + Q+ EA Sbjct: 2043 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE--EARVQAEREAAQSRRQVEEA 2100 Query: 870 ADKVVLHTGKYEELIVCSHEIAASTAQLVAAS---KVKANKHSPHLSRLQECSRTVNERA 926 E L + E A + AQ AA+ + +A + + ++ ++ + + A Sbjct: 2101 -----------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2149 Query: 927 ANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGELR 985 + K EQ + L+ ++L+ +E + Q +L+ E + L+AE R Sbjct: 2150 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2209 Query: 986 KQ 987 Q Sbjct: 2210 SQ 2211 Score = 66.2 bits (160), Expect = 1e-10 Identities = 90/330 (27%), Positives = 146/330 (44%), Gaps = 63/330 (19%) Query: 335 QIESLKREVEMLRSE----LEKIK--LEAQRYIAQLKSQVNA--------LEGELEEQRK 380 ++E +R E R+E L +++ LE QR +A+ +Q A L+ ++E+ Sbjct: 1329 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1388 Query: 381 QKQKALVDNEQ----LRHELAQLRA---AQLEGERSQGLREEAERKASATEARYNKLKEK 433 ++++A VD +Q ++ EL QLR A+++ + Q E R E R +L+ + Sbjct: 1389 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1448 Query: 434 HSELVHVHAE----LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEE 489 +E AE LR A+ A+ +Q+QEE R++ Q V+ ES+ K + Sbjct: 1449 ATERQRGGAEGELQALRARAEEAE--AQKRQAQEEAERLRRQ-------VQDESQRKRQA 1499 Query: 490 KSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKD-----ALSGAVR 544 + + ++K E EA A E RA +AL E RL E+ AL A R Sbjct: 1500 EVELASRVKAEAEA-AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1558 Query: 545 QREADLLAAQSLVRETEAALSR--------------EQQRSSQEQGELQGRLAERESQ-- 588 EA+L + ++ E A L R E +R +Q+Q E + E E + Sbjct: 1559 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1618 Query: 589 ------EQGLRQRLLDEQFAVLRG-AAAEA 611 + LR RL E+ A + A AEA Sbjct: 1619 RWQLKANEALRLRLQAEEVAQQKSLAQAEA 1648 Score = 65.9 bits (159), Expect = 2e-10 Identities = 151/729 (20%), Positives = 289/729 (39%), Gaps = 107/729 (14%) Query: 330 DDRDLQIESLKREVEMLRSELEKIKL---EAQRYIAQLKSQVNALEGELEEQRKQKQKAL 386 D R ++E L R++ R + + +A+R Q+++ A + EQ +Q+Q L Sbjct: 1182 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1241 Query: 387 VDNEQLRHELAQLRA--------------------AQLEGERSQGLREEAERKASATEAR 426 + E+ ++ + + AQLE S + + + + + Sbjct: 1242 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1301 Query: 427 YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ-SQEEVARVKEQLA---FQVEQVKRE 482 Y L+ +SEL + ++ ++ ++T +++ ++ ++++ A +E+LA +E+ ++ Sbjct: 1302 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1361 Query: 483 SELKLEEKSDQLEKLKRELEAK-AGELARAQEALSHTEQSKSELSSRLDTLSAEKDA-LS 540 +E + K+ Q E+ +EL+ + E+ R +EA +Q K + L L +A + Sbjct: 1362 AEAHAQAKA-QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1420 Query: 541 GAVRQREA---DLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA-------------- 583 RQ EA L + +R L +++ +GELQ A Sbjct: 1421 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1480 Query: 584 -----ERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL- 637 R+ Q++ R+R + + A A AEAA Q A+ L++ L L+ + L Sbjct: 1481 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-LRLQAEEAERRLR 1539 Query: 638 ---VSRAQEALDAVSTLEEGHAQYL----TSLADASALVAALTRFSHLAADTIINGGATS 690 V RA++ A+ T + L S A+ +A + + H+A + A Sbjct: 1540 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV-AQLREEAER 1598 Query: 691 HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPK 750 A+R RE R LE QL+ +ALR LQ + + K Sbjct: 1599 RAQQQAEAER----AREEAERELE-RWQLKANEALRLR------------LQAEEVAQQK 1641 Query: 751 SL-DVRQEELGAVVDKEMAATSAAIEDAVRRIE------DMMNQARHASSGVKLEVNERI 803 SL E+ ++E A E AVR+ E + Q ++ +L + + Sbjct: 1642 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1701 Query: 804 LNSCTDLMKA---IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLI-SASKAV 859 + + + +LL LQ+E + + + AK E L+ S ++A Sbjct: 1702 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1761 Query: 860 GWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECS 919 + ++ ++ G++ EL + E A A A + + + E Sbjct: 1762 EESRSTSEKSKQRLEAEAGRFREL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1818 Query: 920 RTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM 979 R + E+ A + +T+ E + I LK++E E + R+ L + +R Sbjct: 1819 RVLAEKLAAIGEATRLKTE-------------AEIALKEKEAENE-RLRRLAEDEAFQRR 1864 Query: 980 RLGELRKQH 988 RL E QH Sbjct: 1865 RLEEQAAQH 1873 Score = 62.4 bits (150), Expect = 2e-09 Identities = 94/410 (22%), Positives = 167/410 (40%), Gaps = 41/410 (10%) Query: 332 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 391 R L E L ++ L ++ K K++A + +LK++ L+ + E ++Q ++ D EQ Sbjct: 2280 RQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2338 Query: 392 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE----LLRK 447 + +LA + +G + E + + EA KL+ AE RK Sbjct: 2339 MAQQLA----EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2394 Query: 448 NA-DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKREL--EAK 504 A + ++L T+ + +E + + L Q +Q ++E +L E +LE+ K +L EAK Sbjct: 2395 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAK 2453 Query: 505 AGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA-- 562 +L + EQ E + + +EKD+L R E + + L ++ A Sbjct: 2454 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2513 Query: 563 -ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSK 621 L EQQR Q+ + + RL S E+ R+ + A E Q+ + + Sbjct: 2514 QQLREEQQRQQQQMEQERQRLV--ASMEEARRR----------QHEAEEGVRRKQEELQQ 2561 Query: 622 LDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAAD 681 L+ + + L Q + + LEE H L + +A A T+ Sbjct: 2562 LEQ----QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK------- 2610 Query: 682 TIING--GATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQ 729 T+ NG A +P R+ A+ L+ G L ++ R Q Sbjct: 2611 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2660 Score = 49.3 bits (116), Expect = 2e-05 Identities = 151/706 (21%), Positives = 265/706 (37%), Gaps = 78/706 (11%) Query: 334 LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 393 L I + E+LR+ E++K EAQ A L ++ A + L++ R Q + + LR Sbjct: 1079 LVIRGTQGAEEVLRAHEEQLK-EAQAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALR 1136 Query: 394 HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 453 EL R AQ GER Q E + + R +L E+ ++ R+ + Sbjct: 1137 DEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1193 Query: 454 QLTVTQQSQEEVARVKEQLAFQVEQVKR---ESELKLEEKSDQLEKLKRELEAKAGELAR 510 QL ++S + + + + EQ++ + E+ Q + L E+E ++ Sbjct: 1194 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1253 Query: 511 AQEALSHTEQSKSELSSRLDTLSAEKDAL------------SGAVRQREADL-------- 550 Q + + +L T A+ + + S +V Q DL Sbjct: 1254 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1313 Query: 551 -LAAQ--SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA 607 L +Q + ET + E++ + Q++ E + RLAE E+ + +QR L E A + Sbjct: 1314 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE--KQRQLAEAHAQAKAQ 1371 Query: 608 AAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA 667 A A LQ ++ + + R ++ D + + + A+ A A Sbjct: 1372 AEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1428 Query: 668 LVAALTRFS--------HLAADTIINGGATSHL-APTDPADRLIDTCRECGARALELMGQ 718 + R L A GGA L A A+ R+ A L Q Sbjct: 1429 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1488 Query: 719 LQDQQALRHMQ----ASLVRTPL------QGILQLGQELKPKSLDVRQEELGAVVDKEMA 768 +QD+ + AS V+ Q LQ +EL+ ++ + + A V++ Sbjct: 1489 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER-AR 1547 Query: 769 ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 828 A+E A R E + Q++ AS K ER L + +R Q E Sbjct: 1548 QVQVALETAQRSAEAEL-QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1606 Query: 829 VESGRGAATQQEFY------AKNSRWTEGLISASKAVGWG-ATQLVEAADKVVLHTGKYE 881 + A + E + A R ++ K++ A + E A++ GK E Sbjct: 1607 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1666 Query: 882 ELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ-- 939 E V E+A +L ++ L+ QE R + A T+ G++Q Sbjct: 1667 EQAVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIR--------LRAETEQGEQQRQ 1716 Query: 940 -IEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGE 983 +E+ + K+QE+E ++ + E + L A + R E Sbjct: 1717 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1762 Score = 45.1 bits (105), Expect = 4e-04 Identities = 136/688 (19%), Positives = 264/688 (38%), Gaps = 67/688 (9%) Query: 337 ESLKREVEMLRS----ELEKIKLEAQR---YIAQLKSQVNALEGELEEQRKQKQKALVDN 389 +SL+R+V+++RS +K E QR + +L Q + + + + + + Sbjct: 883 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 942 Query: 390 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 449 E + QL QG +EE+ + +E + +L+ + E VH L + Sbjct: 943 E---YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 999 Query: 450 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--LKLEEKSDQLEKLKRELEAKAGE 507 + A++ Q++ E L V ++ E+E L L E S L+ ELE G+ Sbjct: 1000 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1059 Query: 508 LARAQE--------------ALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA 553 L + + + T+ ++ L + + L E A+ + + EA + Sbjct: 1060 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASL 1118 Query: 554 QSLVRETEAA-----LSREQQRSSQEQGE-LQGRLAERESQEQGLRQR---LLDEQFAVL 604 + L + EA R++ R +QE GE LQ R ER+ + + R+R LL+ AVL Sbjct: 1119 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1178 Query: 605 -----RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYL 659 R E G + DPL + R QE + A+ + + Sbjct: 1179 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA-----RRRQEQIQAMPLADSQAVR-- 1231 Query: 660 TSLADASALVAALTRFSHLA------ADTIINGGATSHLAPTDPADRLIDTCRECGARAL 713 L AL+ + R A IN L +L + Sbjct: 1232 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1291 Query: 714 ELMGQ--LQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 771 + + +Q+ LR + L Q I + + L+ + R E ++E A Sbjct: 1292 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1351 Query: 772 AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 831 A + R++ + QA+ + E+ +R+ +A S+Q+E+ + Sbjct: 1352 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1411 Query: 832 GRGAATQQEFYAKNSRWTE-GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEI 890 + + + + A+ + E + + + QL EA ++ G EL + Sbjct: 1412 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATER--QRGGAEGEL-----QA 1463 Query: 891 AASTAQLVAASKVKANKHSPHLSR-LQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 949 + A+ A K +A + + L R +Q+ S+ + + + K+ E ++ Sbjct: 1464 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-LQ 1522 Query: 950 GLSLIKLKKQEMETQVRVLELEKTLEAE 977 L ++L+ +E E ++R E+E+ + + Sbjct: 1523 ALEELRLQAEEAERRLRQAEVERARQVQ 1550 >gi|47607492 plectin 1 isoform 1 [Homo sapiens] Length = 4574 Score = 79.0 bits (193), Expect = 2e-14 Identities = 170/688 (24%), Positives = 284/688 (41%), Gaps = 102/688 (14%) Query: 334 LQIESLKR-------EVEMLRS---ELEKIKLEAQRYIAQLKSQV-----NALEGELE-- 376 LQ+E+ +R E++ LR+ E E K +AQ +L+ QV + E+E Sbjct: 1486 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1545 Query: 377 -------EQRKQKQKALVDNEQLR--HELAQLRAAQLEGERSQGLREEAERKASATEARY 427 E ++KQ+AL E+LR E A+ R Q E ER++ ++ E + EA Sbjct: 1546 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-- 1603 Query: 428 NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 487 +L+ K + A+L R + + + V Q +E R ++Q + E+ + E+E +L Sbjct: 1604 -ELQSKRASFAEKTAQLERSLQE--EHVAVAQLREEAERRAQQQA--EAERAREEAEREL 1658 Query: 488 EE---KSDQLEKLKRELEAKAGELARAQ-EALSHTEQSKSELSSRLDTLSAEKDALSGAV 543 E K+++ +L+ + E A + + AQ EA E+++ E R A AV Sbjct: 1659 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAV 1711 Query: 544 RQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 603 RQRE LA Q L ++ + A QQR + EQ EL AE E EQ +++LL+E+ A Sbjct: 1712 RQRE---LAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQ--QRQLLEEELAR 1765 Query: 604 LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA 663 L+ AA A Q+ L+ L L S+A+ ++ ST E+ + Sbjct: 1766 LQREAAAATQKRQE----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR------ 1815 Query: 664 DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 723 L A RF LA + A A + A R E AR Q + Sbjct: 1816 ----LEAEAGRFRELAEE------AARLRALAEEAKRQRQLAEEDAAR--------QRAE 1857 Query: 724 ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR--- 780 A R + L L+ E+ K + E L + + E E A + Sbjct: 1858 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1917 Query: 781 IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG-AATQQ 839 IE+ + Q R AS +LE + ++ D ++ R + +L+ ++ G A + Sbjct: 1918 IEERLAQLRKASDS-ELERQKGLVE---DTLRQRRQVEEEILALKASFEKAAAGKAELEL 1973 Query: 840 EFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEEL--IVCSHEIAASTAQL 897 E S + L S +A A Q AA++ E + + + E AA + Sbjct: 1974 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2033 Query: 898 VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLK 957 + RL+E R E A + + ++ Q++++ + K Sbjct: 2034 ALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEE------------K 2079 Query: 958 KQEMETQVRVLELEKTLEAERMRLGELR 985 Q + EL++TL+ E+ L +LR Sbjct: 2080 AHAFAVQQKEQELQQTLQQEQSVLDQLR 2107 Score = 77.8 bits (190), Expect = 5e-14 Identities = 158/768 (20%), Positives = 296/768 (38%), Gaps = 96/768 (12%) Query: 330 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 389 +D Q ++ E+ L++ EK A A+L+ ++ + E+ + K++A ++ Sbjct: 1941 EDTLRQRRQVEEEILALKASFEK----AAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1996 Query: 390 EQLRHELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 445 + R A+ + E E +S EEA R+ A +LK K E A L Sbjct: 1997 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRL 2051 Query: 446 RKNAD--TAKQLTVTQQSQEEVARVKEQL-AFQVEQVKRESELKLEEKSDQLEKLKRELE 502 R+ A+ +A+QL + Q++ ++ + +E+ AF V+Q ++E + L+++ L++L+ E E Sbjct: 2052 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2111 Query: 503 AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 562 A A+EA E+ ++ +++ K + + R AA+ L +E E Sbjct: 2112 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2171 Query: 563 ALSREQQRSSQEQGELQGRLAERESQ----EQGLRQR----------------------L 596 +R Q + Q AE E EQ LRQ+ L Sbjct: 2172 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2231 Query: 597 LDEQFAVLRGAAAEAAGILQDAVSKLD---------DPLHLRCTSSPDYLVSRAQEALDA 647 LDE+ L+ A EAA +L L R + L+ R ++ Sbjct: 2232 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2291 Query: 648 VSTLE-EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 706 E E Q A S R LA + + A + + + + R Sbjct: 2292 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2351 Query: 707 -ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELK--PKSLDV---RQEELG 760 + A L+ +L +QA R L Q QL +E + ++L+ RQ E+ Sbjct: 2352 LKAEAELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2406 Query: 761 AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 820 A ++ + R ED + A E+ E++ T+L ++ + Sbjct: 2407 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR--TELATQEKVTLVQ 2459 Query: 821 STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLH---- 876 + +Q++ +S A +E A+ R E L +K + + ++ + +L Sbjct: 2460 TLEIQRQ--QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2517 Query: 877 -----TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVA 931 + + L+ I A+L + + K Q + + + +VA Sbjct: 2518 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2577 Query: 932 STKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGE----LRKQ 987 S + + + + + G+ + + Q++E Q R + E+ L E RL E L +Q Sbjct: 2578 SMEEARRRQHEAE----EGVRRKQEELQQLEQQRR--QQEELLAEENQRLREQLQLLEEQ 2631 Query: 988 HYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLD 1035 H A+ + EEV A +++ + L P+ +H D Sbjct: 2632 H----RAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEPEHSFD 2674 Score = 73.9 bits (180), Expect = 7e-13 Identities = 151/697 (21%), Positives = 281/697 (40%), Gaps = 81/697 (11%) Query: 344 EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA-- 401 + L +E E I+L A+ Q + Q LE EL +++ A ++L ELA++RA Sbjct: 1734 QRLAAEQELIRLRAET--EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1791 Query: 402 -------AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 454 A+ E E S+ E+++++ A R+ +L E+ + L AE ++ A++ Sbjct: 1792 EVLLASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARL-RALAEEAKRQRQLAEE 1849 Query: 455 LTVTQQSQEEVARVKEQLAF-QVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQE 513 Q+++ E ++ A + ++K E+E+ L+EK + E+L+R E +A + R +E Sbjct: 1850 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1909 Query: 514 ALSHTEQSKSELSSRL--------DTLSAEKDALSGAVRQR---EADLLAAQSLVR---- 558 Q K+++ RL L +K + +RQR E ++LA ++ Sbjct: 1910 ---QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1966 Query: 559 ---ETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAE 610 E E L R E S+EQ EL+ + + E+ R+R +E+ A E Sbjct: 1967 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2026 Query: 611 AAGILQDAV-------SKLDDPLHLRCTSSPDYL--VSRAQEALDAVSTLEEGHAQYLTS 661 AA + A+ +K+++ LR + + + AQEA A L+ + + Sbjct: 2027 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA--AQKRLQAEEKAHAFA 2084 Query: 662 LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECG-----ARALELM 716 + + + D + + A + + + RE E + Sbjct: 2085 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2144 Query: 717 GQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIED 776 Q ++QA QA L+ +E + ++ Q E A+ K+ A A +E Sbjct: 2145 KQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQ--AADAEMEK 2196 Query: 777 AVRRIEDMMNQARHASS-----GVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 831 + E + Q ++LE + N + ++ ++ T + + ++ E Sbjct: 2197 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2256 Query: 832 GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQ--LVEAADKVVLHTGKYEELIVCSHE 889 Q E +K E A TQ L E A+K+ + L V + E Sbjct: 2257 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2316 Query: 890 IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 949 AA QL A + A + + L+E + V E K+ E ++ + + Sbjct: 2317 -AARLRQL--AEEDLAQQRALAEKMLKEKMQAVQE-----ATRLKAEAELLQQQKELAQE 2368 Query: 950 GLSLIKLKKQEMETQV--RVLELEKTLEAERMRLGEL 984 ++ K++M Q+ ++TLEAER R E+ Sbjct: 2369 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2405 Score = 68.6 bits (166), Expect = 3e-11 Identities = 153/722 (21%), Positives = 289/722 (40%), Gaps = 104/722 (14%) Query: 336 IESLKREVEMLRSELEKIKLEAQRYI-AQLKSQVNALEGELEEQRK-------QKQKALV 387 +E L+ + E L + ++E R + L++ + E EL+ +R Q +++L Sbjct: 1565 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1624 Query: 388 DNE----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 443 + QLR E + Q E ER+ REEAER+ + + N+ + V + Sbjct: 1625 EEHVAVAQLREEAERRAQQQAEAERA---REEAERELERWQLKANEALRLRLQAEEVAQQ 1681 Query: 444 LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE------------------- 484 A+ KQ ++ + +EQ Q E ++E E Sbjct: 1682 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1741 Query: 485 -LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL--SG 541 ++L +++Q E+ ++ LE ELAR Q + Q + EL + L + AE + L S Sbjct: 1742 LIRLRAETEQGEQQRQLLEE---ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1798 Query: 542 AVRQREADLLAAQSLVR-ETEAALSRE------QQRSSQEQGELQGRLAERESQEQGLR- 593 A + E+ + +S R E EA RE + R+ E+ + Q +LAE ++ Q Sbjct: 1799 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1858 Query: 594 QRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEE 653 +R+L E+ A A EA + +A L + + + L A++ LEE Sbjct: 1859 ERVLAEKLA----AIGEATRLKTEAEIALKEK-----EAENERLRRLAEDEAFQRRRLEE 1909 Query: 654 GHAQYLTSLADASALV-----AALTRFSHLAADTIINGGATSH--LAPTDPADRLIDTCR 706 AQ+ + + A + + L R L DT+ LA ++ Sbjct: 1910 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK-----A 1964 Query: 707 ECGARALEL-MGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV 763 G LEL +G+++ + LR + + + Q L +E + + + R ++ A Sbjct: 1965 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2024 Query: 764 DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT--- 820 ++ AA+E+ V R++ + +AR + E ++ + K ++ Sbjct: 2025 EEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2083 Query: 821 ---------STSLQKE--IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEA 869 +LQ+E +++ RG A A+ + E + A + Q+ EA Sbjct: 2084 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE--EARVQAEREAAQSRRQVEEA 2141 Query: 870 ADKVVLHTGKYEELIVCSHEIAASTAQLVAAS---KVKANKHSPHLSRLQECSRTVNERA 926 E L + E A + AQ AA+ + +A + + ++ ++ + + A Sbjct: 2142 -----------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2190 Query: 927 ANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGELR 985 + K EQ + L+ ++L+ +E + Q +L+ E + L+AE R Sbjct: 2191 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2250 Query: 986 KQ 987 Q Sbjct: 2251 SQ 2252 Score = 66.2 bits (160), Expect = 1e-10 Identities = 90/330 (27%), Positives = 146/330 (44%), Gaps = 63/330 (19%) Query: 335 QIESLKREVEMLRSE----LEKIK--LEAQRYIAQLKSQVNA--------LEGELEEQRK 380 ++E +R E R+E L +++ LE QR +A+ +Q A L+ ++E+ Sbjct: 1370 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1429 Query: 381 QKQKALVDNEQ----LRHELAQLRA---AQLEGERSQGLREEAERKASATEARYNKLKEK 433 ++++A VD +Q ++ EL QLR A+++ + Q E R E R +L+ + Sbjct: 1430 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1489 Query: 434 HSELVHVHAE----LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEE 489 +E AE LR A+ A+ +Q+QEE R++ Q V+ ES+ K + Sbjct: 1490 ATERQRGGAEGELQALRARAEEAE--AQKRQAQEEAERLRRQ-------VQDESQRKRQA 1540 Query: 490 KSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKD-----ALSGAVR 544 + + ++K E EA A E RA +AL E RL E+ AL A R Sbjct: 1541 EVELASRVKAEAEA-AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1599 Query: 545 QREADLLAAQSLVRETEAALSR--------------EQQRSSQEQGELQGRLAERESQ-- 588 EA+L + ++ E A L R E +R +Q+Q E + E E + Sbjct: 1600 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1659 Query: 589 ------EQGLRQRLLDEQFAVLRG-AAAEA 611 + LR RL E+ A + A AEA Sbjct: 1660 RWQLKANEALRLRLQAEEVAQQKSLAQAEA 1689 Score = 65.9 bits (159), Expect = 2e-10 Identities = 151/729 (20%), Positives = 289/729 (39%), Gaps = 107/729 (14%) Query: 330 DDRDLQIESLKREVEMLRSELEKIKL---EAQRYIAQLKSQVNALEGELEEQRKQKQKAL 386 D R ++E L R++ R + + +A+R Q+++ A + EQ +Q+Q L Sbjct: 1223 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1282 Query: 387 VDNEQLRHELAQLRA--------------------AQLEGERSQGLREEAERKASATEAR 426 + E+ ++ + + AQLE S + + + + + Sbjct: 1283 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1342 Query: 427 YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ-SQEEVARVKEQLA---FQVEQVKRE 482 Y L+ +SEL + ++ ++ ++T +++ ++ ++++ A +E+LA +E+ ++ Sbjct: 1343 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1402 Query: 483 SELKLEEKSDQLEKLKRELEAK-AGELARAQEALSHTEQSKSELSSRLDTLSAEKDA-LS 540 +E + K+ Q E+ +EL+ + E+ R +EA +Q K + L L +A + Sbjct: 1403 AEAHAQAKA-QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1461 Query: 541 GAVRQREA---DLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA-------------- 583 RQ EA L + +R L +++ +GELQ A Sbjct: 1462 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1521 Query: 584 -----ERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL- 637 R+ Q++ R+R + + A A AEAA Q A+ L++ L L+ + L Sbjct: 1522 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-LRLQAEEAERRLR 1580 Query: 638 ---VSRAQEALDAVSTLEEGHAQYL----TSLADASALVAALTRFSHLAADTIINGGATS 690 V RA++ A+ T + L S A+ +A + + H+A + A Sbjct: 1581 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV-AQLREEAER 1639 Query: 691 HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPK 750 A+R RE R LE QL+ +ALR LQ + + K Sbjct: 1640 RAQQQAEAER----AREEAERELE-RWQLKANEALRLR------------LQAEEVAQQK 1682 Query: 751 SL-DVRQEELGAVVDKEMAATSAAIEDAVRRIE------DMMNQARHASSGVKLEVNERI 803 SL E+ ++E A E AVR+ E + Q ++ +L + + Sbjct: 1683 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1742 Query: 804 LNSCTDLMKA---IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLI-SASKAV 859 + + + +LL LQ+E + + + AK E L+ S ++A Sbjct: 1743 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1802 Query: 860 GWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECS 919 + ++ ++ G++ EL + E A A A + + + E Sbjct: 1803 EESRSTSEKSKQRLEAEAGRFREL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1859 Query: 920 RTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM 979 R + E+ A + +T+ E + I LK++E E + R+ L + +R Sbjct: 1860 RVLAEKLAAIGEATRLKTE-------------AEIALKEKEAENE-RLRRLAEDEAFQRR 1905 Query: 980 RLGELRKQH 988 RL E QH Sbjct: 1906 RLEEQAAQH 1914 Score = 62.4 bits (150), Expect = 2e-09 Identities = 94/410 (22%), Positives = 167/410 (40%), Gaps = 41/410 (10%) Query: 332 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 391 R L E L ++ L ++ K K++A + +LK++ L+ + E ++Q ++ D EQ Sbjct: 2321 RQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2379 Query: 392 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE----LLRK 447 + +LA + +G + E + + EA KL+ AE RK Sbjct: 2380 MAQQLA----EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2435 Query: 448 NA-DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKREL--EAK 504 A + ++L T+ + +E + + L Q +Q ++E +L E +LE+ K +L EAK Sbjct: 2436 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAK 2494 Query: 505 AGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA-- 562 +L + EQ E + + +EKD+L R E + + L ++ A Sbjct: 2495 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2554 Query: 563 -ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSK 621 L EQQR Q+ + + RL S E+ R+ + A E Q+ + + Sbjct: 2555 QQLREEQQRQQQQMEQERQRLV--ASMEEARRR----------QHEAEEGVRRKQEELQQ 2602 Query: 622 LDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAAD 681 L+ + + L Q + + LEE H L + +A A T+ Sbjct: 2603 LEQ----QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK------- 2651 Query: 682 TIING--GATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQ 729 T+ NG A +P R+ A+ L+ G L ++ R Q Sbjct: 2652 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2701 Score = 49.3 bits (116), Expect = 2e-05 Identities = 151/706 (21%), Positives = 265/706 (37%), Gaps = 78/706 (11%) Query: 334 LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 393 L I + E+LR+ E++K EAQ A L ++ A + L++ R Q + + LR Sbjct: 1120 LVIRGTQGAEEVLRAHEEQLK-EAQAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALR 1177 Query: 394 HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 453 EL R AQ GER Q E + + R +L E+ ++ R+ + Sbjct: 1178 DEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1234 Query: 454 QLTVTQQSQEEVARVKEQLAFQVEQVKR---ESELKLEEKSDQLEKLKRELEAKAGELAR 510 QL ++S + + + + EQ++ + E+ Q + L E+E ++ Sbjct: 1235 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1294 Query: 511 AQEALSHTEQSKSELSSRLDTLSAEKDAL------------SGAVRQREADL-------- 550 Q + + +L T A+ + + S +V Q DL Sbjct: 1295 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1354 Query: 551 -LAAQ--SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA 607 L +Q + ET + E++ + Q++ E + RLAE E+ + +QR L E A + Sbjct: 1355 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE--KQRQLAEAHAQAKAQ 1412 Query: 608 AAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA 667 A A LQ ++ + + R ++ D + + + A+ A A Sbjct: 1413 AEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1469 Query: 668 LVAALTRFS--------HLAADTIINGGATSHL-APTDPADRLIDTCRECGARALELMGQ 718 + R L A GGA L A A+ R+ A L Q Sbjct: 1470 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1529 Query: 719 LQDQQALRHMQ----ASLVRTPL------QGILQLGQELKPKSLDVRQEELGAVVDKEMA 768 +QD+ + AS V+ Q LQ +EL+ ++ + + A V++ Sbjct: 1530 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER-AR 1588 Query: 769 ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 828 A+E A R E + Q++ AS K ER L + +R Q E Sbjct: 1589 QVQVALETAQRSAEAEL-QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1647 Query: 829 VESGRGAATQQEFY------AKNSRWTEGLISASKAVGWG-ATQLVEAADKVVLHTGKYE 881 + A + E + A R ++ K++ A + E A++ GK E Sbjct: 1648 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1707 Query: 882 ELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ-- 939 E V E+A +L ++ L+ QE R + A T+ G++Q Sbjct: 1708 EQAVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIR--------LRAETEQGEQQRQ 1757 Query: 940 -IEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGE 983 +E+ + K+QE+E ++ + E + L A + R E Sbjct: 1758 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1803 Score = 45.1 bits (105), Expect = 4e-04 Identities = 136/688 (19%), Positives = 264/688 (38%), Gaps = 67/688 (9%) Query: 337 ESLKREVEMLRS----ELEKIKLEAQR---YIAQLKSQVNALEGELEEQRKQKQKALVDN 389 +SL+R+V+++RS +K E QR + +L Q + + + + + + Sbjct: 924 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 983 Query: 390 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 449 E + QL QG +EE+ + +E + +L+ + E VH L + Sbjct: 984 E---YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1040 Query: 450 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--LKLEEKSDQLEKLKRELEAKAGE 507 + A++ Q++ E L V ++ E+E L L E S L+ ELE G+ Sbjct: 1041 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1100 Query: 508 LARAQE--------------ALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA 553 L + + + T+ ++ L + + L E A+ + + EA + Sbjct: 1101 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASL 1159 Query: 554 QSLVRETEAA-----LSREQQRSSQEQGE-LQGRLAERESQEQGLRQR---LLDEQFAVL 604 + L + EA R++ R +QE GE LQ R ER+ + + R+R LL+ AVL Sbjct: 1160 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1219 Query: 605 -----RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYL 659 R E G + DPL + R QE + A+ + + Sbjct: 1220 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA-----RRRQEQIQAMPLADSQAVR-- 1272 Query: 660 TSLADASALVAALTRFSHLA------ADTIINGGATSHLAPTDPADRLIDTCRECGARAL 713 L AL+ + R A IN L +L + Sbjct: 1273 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1332 Query: 714 ELMGQ--LQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 771 + + +Q+ LR + L Q I + + L+ + R E ++E A Sbjct: 1333 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1392 Query: 772 AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 831 A + R++ + QA+ + E+ +R+ +A S+Q+E+ + Sbjct: 1393 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1452 Query: 832 GRGAATQQEFYAKNSRWTE-GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEI 890 + + + + A+ + E + + + QL EA ++ G EL + Sbjct: 1453 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATER--QRGGAEGEL-----QA 1504 Query: 891 AASTAQLVAASKVKANKHSPHLSR-LQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 949 + A+ A K +A + + L R +Q+ S+ + + + K+ E ++ Sbjct: 1505 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-LQ 1563 Query: 950 GLSLIKLKKQEMETQVRVLELEKTLEAE 977 L ++L+ +E E ++R E+E+ + + Sbjct: 1564 ALEELRLQAEEAERRLRQAEVERARQVQ 1591 >gi|21450705 leucine rich repeat containing 45 [Homo sapiens] Length = 670 Score = 79.0 bits (193), Expect = 2e-14 Identities = 82/321 (25%), Positives = 148/321 (46%), Gaps = 47/321 (14%) Query: 335 QIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 394 Q++ L+R+ + +L + + E A+LK + E L+ ++++ +++L D+E LR Sbjct: 375 QVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRI 434 Query: 395 ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 454 + + LE E + ++E +R EA L+E EL V A L + ++ Sbjct: 435 KEVEHMTRHLE-ESEKAMQERVQR----LEAARLSLEE---ELSRVKAAALSERGQAEEE 486 Query: 455 LTVTQ-----QSQEEVARVKEQL-------------AFQVEQVKRESELKLEEKSDQLEK 496 L + + Q+ +A ++++L Q +QV E++ ++ + Q+E Sbjct: 487 LIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEG 546 Query: 497 LKRELEAKAGELA-RAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQS 555 L+R LE EL+ + QE ++ + + EL + L AE LAAQ Sbjct: 547 LRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAE---------------LAAQE 591 Query: 556 LVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQ--RLLDEQFAVLRGAAAEAAG 613 +RE AAL R+ + + + E L +RES+ LR+ RL + + A +R A+ A Sbjct: 592 ALREKAAALERQLKVMASDHRE---ALLDRESENASLREKLRLREAEIARIRDEEAQRAS 648 Query: 614 ILQDAVSKLDDPLHLRCTSSP 634 LQ+AV +R S P Sbjct: 649 FLQNAVLAYVQASPVRTLSPP 669 Score = 57.4 bits (137), Expect = 7e-08 Identities = 81/373 (21%), Positives = 152/373 (40%), Gaps = 59/373 (15%) Query: 328 VKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVN---ALEGELEEQRKQKQK 384 +++++ Q L ++ R E+ K + + QL+ +N ++ L+ + + + Sbjct: 251 LREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEA 310 Query: 385 ALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEA--RYNKL-------KEKHS 435 AL +EQ +L +L A + + S R+ E K EA R +KL EK+ Sbjct: 311 ALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNL 370 Query: 436 ELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQ----------------- 478 L + EL RK +QL T+Q ++ + A Q E+ Sbjct: 371 LLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSE 430 Query: 479 ---VK---------RESELKLEEKSDQLEKLKRELE--------AKAGELARAQEAL--- 515 +K ESE ++E+ +LE + LE A E +A+E L Sbjct: 431 SLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKA 490 Query: 516 -----SHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQR 570 +Q + L +L L+ +D GA Q++ + AQ+ V + + ++R Sbjct: 491 KSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRR 550 Query: 571 SSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRC 630 + Q EL + ER ++ +R L ++ + AA+ A L++ + L+ L + Sbjct: 551 LEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEA--LREKAAALERQLKVMA 608 Query: 631 TSSPDYLVSRAQE 643 + + L+ R E Sbjct: 609 SDHREALLDRESE 621 Score = 39.3 bits (90), Expect = 0.020 Identities = 30/97 (30%), Positives = 44/97 (45%), Gaps = 4/97 (4%) Query: 334 LQIESLKREVEMLRSEL----EKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 389 LQ+E L+R +E L+ EL ++ E R +L+ Q L+ EL Q ++KA Sbjct: 542 LQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEALREKAAALE 601 Query: 390 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEAR 426 QL+ + R A L+ E E R A AR Sbjct: 602 RQLKVMASDHREALLDRESENASLREKLRLREAEIAR 638 >gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo sapiens] Length = 1972 Score = 78.6 bits (192), Expect = 3e-14 Identities = 156/765 (20%), Positives = 314/765 (41%), Gaps = 107/765 (13%) Query: 337 ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKAL--VDNEQLRH 394 E ++E+E L+ +LE + IA L++Q+ L+ +L ++ ++ Q AL +D+E + Sbjct: 1047 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1106 Query: 395 ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 454 A + +LEG S L+E+ + + +A + ++ EL + EL TA Q Sbjct: 1107 NNALKKIRELEGHISD-LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1165 Query: 455 LTVTQQSQEEVARVKEQL-------AFQVEQVKRESELKLEEKSDQLEKLKR-------- 499 + + ++EV +K+ L QV++++++ +EE ++QLE+ KR Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225 Query: 500 ------------------------------ELEAKAGELARAQEALSHTEQSKSELSSRL 529 +LEA+ EL Q S E++++EL+ ++ Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL---QSKCSDGERARAELNDKV 1282 Query: 530 DTLSAEKDALSGAVRQREA-------DLLAAQSLVRETEAALSREQQRSSQEQGELQGRL 582 L E ++++G + + E D+ + S +++T+ L E ++ +L+ Sbjct: 1283 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1342 Query: 583 AERESQEQGLRQRL-----LDEQFAVLRGAAAEAAGILQDAVSKLD--DPLHLRCTSSPD 635 ER S + L + + L+ + L +++ LQD S ++ + R + Sbjct: 1343 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1402 Query: 636 YLVSRAQEALDAVSTLEEGHAQYLTSLAD-----------ASALVAALTRFSHLAADTII 684 L + +E A LE+ + L D S L +F L A+ Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE--- 1459 Query: 685 NGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQ-QALRHMQAS--LVRTPLQGIL 741 +S A D DR RE +AL L L++ +A ++ + +++ ++ ++ Sbjct: 1460 EKNISSKYA--DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1517 Query: 742 ----QLGQ-----ELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHAS 792 +G+ E ++L+ + EE+ ++ E+ A EDA R+E M + Sbjct: 1518 SSKDDVGKNVHELEKSKRALETQMEEMKTQLE-ELEDELQATEDAKLRLEVNMQALK--- 1573 Query: 793 SGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGL 852 + ++ R + + R L T L+ E + AA +++ Sbjct: 1574 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA 1633 Query: 853 ISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHL 912 SA K QL + ++ + E+ EI A+ + ++ KA L Sbjct: 1634 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKE----NEKKAKSLEADL 1689 Query: 913 SRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEK 972 +LQE ERA K E++ + SG + ++ +K+ +E R+ +LE+ Sbjct: 1690 MQLQE-DLAAAERARKQADLEK---EELAEELASSLSGRNALQDEKRRLE--ARIAQLEE 1743 Query: 973 TLEAERMRLGELRKQHYVLAGASGSPGEEVAIRPSTAPRSVTTKK 1017 LE E+ + + + + E+A STA ++ + ++ Sbjct: 1744 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1788 Score = 74.7 bits (182), Expect = 4e-13 Identities = 72/286 (25%), Positives = 133/286 (46%), Gaps = 32/286 (11%) Query: 332 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNE- 390 RD Q E +R+++ E E + ++ A + LEG+L++ Q A+ E Sbjct: 1583 RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1642 Query: 391 ---QLRHELAQLRAAQLEGERSQGLREEA-------ERKASATEARYNKLKEKHSELVHV 440 QLR AQ++ Q E E ++ R+E E+KA + EA +L+E + Sbjct: 1643 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA---- 1698 Query: 441 HAELLRKNADTAKQ---------LTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKS 491 AE RK AD K+ L+ Q+E R++ ++A Q+E+ E + +E S Sbjct: 1699 -AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA-QLEEELEEEQGNMEAMS 1756 Query: 492 DQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLL 551 D++ K ++ E + ELA + E ++ +L + L ++ + GAV+ + + Sbjct: 1757 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1816 Query: 552 AAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLL 597 AA EA +++ +++ QE E Q + +++ L++ LL Sbjct: 1817 AA------LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1856 Score = 65.5 bits (158), Expect = 3e-10 Identities = 146/748 (19%), Positives = 275/748 (36%), Gaps = 115/748 (15%) Query: 332 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLK-----SQVNALEGELEEQRKQKQKAL 386 + LQ E K +ML E + + EA R QL+ +++ LE E+ Q K Sbjct: 939 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998 Query: 387 VDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLR 446 + + L ++ L + L EE E+ + T KLK KH ++ L+ Sbjct: 999 KERKLLEERISDL---------TTNLAEEEEKAKNLT-----KLKNKHESMISELEVRLK 1044 Query: 447 KNADTAKQLTVTQQS---------------QEEVARVKEQLAFQVEQV------------ 479 K + ++L ++ Q ++A +K QLA + E++ Sbjct: 1045 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 1104 Query: 480 -----------------------------KRESELKLEEKSDQLEKLKRELEAKAGELAR 510 + ++E + + ++LE LK ELE A Sbjct: 1105 QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT 1164 Query: 511 AQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREA----DLLAAQSLVRETEAALSR 566 QE + EQ + L LD + +A +RQ+ A +L + +A L + Sbjct: 1165 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1224 Query: 567 EQQRSSQEQGELQG--RLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDD 624 +Q +E +L G R+ + QE +++ L+ Q L+ ++ + A ++L+D Sbjct: 1225 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG----ERARAELND 1280 Query: 625 PLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTII 684 +H + + + + EA L + A + L D L+ TR L T + Sbjct: 1281 KVH-KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-QKLNVSTKL 1338 Query: 685 NGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLG 744 + D D ++ + L QL D + AS V +G + Sbjct: 1339 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1398 Query: 745 QELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERIL 804 +E+ ++L + EE A DK + ++ + D+ NQ + S+ LE +R Sbjct: 1399 KEI--ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN---LEKKQR-- 1451 Query: 805 NSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGAT 864 K +LL K E R A +E K L A + A Sbjct: 1452 -------KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE-----AK 1499 Query: 865 QLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVN- 923 + +E +K++ + E+L+ ++ + +L + + + ++L+E + Sbjct: 1500 EELERTNKML--KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1557 Query: 924 ------ERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAE 977 N+ A + ++ RD + ++ + E ET++ ++ L A Sbjct: 1558 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAA 1617 Query: 978 RMRLGELRKQHYVLAGASGSPGEEVAIR 1005 + E + L S G E AI+ Sbjct: 1618 AKKKLEGDLKDLELQADSAIKGREEAIK 1645 Score = 64.7 bits (156), Expect = 4e-10 Identities = 143/728 (19%), Positives = 303/728 (41%), Gaps = 99/728 (13%) Query: 334 LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 393 LQ+ + E++ EL+K K Q+ +LK ++ +L E++ Q+ L +L Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELY 903 Query: 394 HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 453 E ++R R ++E E EAR + +++ +L ++ ++ D + Sbjct: 904 AEAEEMRV------RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957 Query: 454 QLTVTQQSQEEVARVKEQLAFQVEQVKRESELK--------LEEKSDQLEKLKRELEAKA 505 QL +EE AR K Q+E+V E+++K +++++++L K ++ LE + Sbjct: 958 QL-----EEEEAARQK----LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1008 Query: 506 GE----LARAQEALSHTEQSK-------SELSSRLDTLSAEKDALSGAVRQREADLLAAQ 554 + LA +E + + K SEL RL + L R+ E D Sbjct: 1009 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1068 Query: 555 SLVRETEAALSREQQRSSQEQGELQGRLA----ERESQEQGLR------------QRLLD 598 + + +A ++ + + ++++ ELQ LA E + L+ Q LD Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1128 Query: 599 EQFAVLRGAAAEAAGI---LQDAVSKLDDPLHLRCT-----SSPDYLVSRAQEALDAVST 650 + A A + + L+ ++L+D L T + + V+ ++ALD + Sbjct: 1129 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1188 Query: 651 LEEGHAQYLTS--LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLI---DTC 705 E Q + L L +F A+ + T D A L Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN-LDKNKQTLEKENADLAGELRVLGQAK 1247 Query: 706 RECGARALELMGQLQDQQALRHMQASLVRTPLQG-ILQLGQELKPKSLDVRQEELGAV-V 763 +E + +L Q+Q+ Q+ + R L + +L E++ + + + E A+ + Sbjct: 1248 QEVEHKKKKLEAQVQELQS-KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1306 Query: 764 DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNER--ILNSCTDLMKAIRLLVTTS 821 K++A+ S+ ++D +++ Q + S+ ++ ER + + + M+A + L Sbjct: 1307 AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1366 Query: 822 TSLQKEIVESGRG----AATQQEFYAKNSRWTEGLISAS-----KAVGWG-----ATQLV 867 ++L ++ +S + A+T + R+ + + + + KA + +L Sbjct: 1367 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1426 Query: 868 EAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAA 927 + D +V+ +L+ + QL+A K ++K++ R + +R E+ Sbjct: 1427 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR---EKET 1483 Query: 928 NVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQV--------RVLELEKTLEAERM 979 ++ ++ +E +E ++ ++ + K+ K EME V V ELEK+ A Sbjct: 1484 KALSLARALEEALEAKEELERTN----KMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539 Query: 980 RLGELRKQ 987 ++ E++ Q Sbjct: 1540 QMEEMKTQ 1547 Score = 63.5 bits (153), Expect = 1e-09 Identities = 126/565 (22%), Positives = 212/565 (37%), Gaps = 106/565 (18%) Query: 335 QIESLKREVEMLR---SELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 391 ++ L+ EVE + +E E ++ + +A L SQ+ + L+E+ +QK Q Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340 Query: 392 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADT 451 L E L+ QL+ E ++ ER S + + K+K + L Sbjct: 1341 LEEERNSLQ-DQLDEEME--AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397 Query: 452 AKQL-TVTQQSQEEVARV-----------------------KEQLAFQVEQVKRE-SELK 486 K++ +TQQ +E+ A + QL +E+ +R+ +L Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457 Query: 487 LEEKS---------DQLEKLKRELEAKAGELARA-QEALSHTEQ---------------- 520 EEK+ D+ E RE E KA LARA +EAL E+ Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1517 Query: 521 -SKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQ 579 SK ++ + L K AL + + + L + ++ TE A R + +G+ + Sbjct: 1518 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1577 Query: 580 GRLAERESQEQGLR---QRLLDE----------QFAVLRGAAAEAAGILQDAVSKLDDPL 626 L R+ Q + R QR L E Q A+ A + G L+D + D + Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637 Query: 627 HLRCTSSPDYLVSRAQ------EALDAVSTLEEGHAQYLTSLADASALVAALTRF----- 675 R + +AQ E DA ++ +E A + A +L A L + Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1697 Query: 676 ----SHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQAS 731 + AD A + + L D R AR +L +L+++Q + Sbjct: 1698 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1757 Query: 732 LVRTPLQGILQLGQEL-------------------KPKSLDVRQEELGAVVDKEMAATSA 772 VR Q QL EL + K L + E+ V + +T A Sbjct: 1758 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1817 Query: 773 AIEDAVRRIEDMMNQ-ARHASSGVK 796 A+E + ++E+ + Q AR + K Sbjct: 1818 ALEAKIAQLEEQVEQEAREKQAATK 1842 Score = 55.8 bits (133), Expect = 2e-07 Identities = 58/226 (25%), Positives = 107/226 (47%), Gaps = 15/226 (6%) Query: 333 DLQIESLKREVEMLRS-----ELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALV 387 DL+ E L E+ S + EK +LEA+ IAQL+ ++ +G +E + +KA Sbjct: 1707 DLEKEELAEELASSLSGRNALQDEKRRLEAR--IAQLEEELEEEQGNMEAMSDRVRKATQ 1764 Query: 388 DNEQLRHELAQLR--AAQLEGERSQGLREEAERKASATE---ARYNKLKEKHSELVHVHA 442 EQL +ELA R A + E R Q R+ E ++ E A +K K + L A Sbjct: 1765 QAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA 1824 Query: 443 ELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESEL---KLEEKSDQLEKLKR 499 +L + A++ +S ++ + +++ QVE ++ +E + E+ + ++++LKR Sbjct: 1825 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1884 Query: 500 ELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQ 545 +LE E R ++ E + + + E +AL +R+ Sbjct: 1885 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930 >gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo sapiens] Length = 1979 Score = 78.6 bits (192), Expect = 3e-14 Identities = 156/765 (20%), Positives = 314/765 (41%), Gaps = 107/765 (13%) Query: 337 ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKAL--VDNEQLRH 394 E ++E+E L+ +LE + IA L++Q+ L+ +L ++ ++ Q AL +D+E + Sbjct: 1054 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1113 Query: 395 ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 454 A + +LEG S L+E+ + + +A + ++ EL + EL TA Q Sbjct: 1114 NNALKKIRELEGHISD-LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172 Query: 455 LTVTQQSQEEVARVKEQL-------AFQVEQVKRESELKLEEKSDQLEKLKR-------- 499 + + ++EV +K+ L QV++++++ +EE ++QLE+ KR Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232 Query: 500 ------------------------------ELEAKAGELARAQEALSHTEQSKSELSSRL 529 +LEA+ EL Q S E++++EL+ ++ Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL---QSKCSDGERARAELNDKV 1289 Query: 530 DTLSAEKDALSGAVRQREA-------DLLAAQSLVRETEAALSREQQRSSQEQGELQGRL 582 L E ++++G + + E D+ + S +++T+ L E ++ +L+ Sbjct: 1290 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1349 Query: 583 AERESQEQGLRQRL-----LDEQFAVLRGAAAEAAGILQDAVSKLD--DPLHLRCTSSPD 635 ER S + L + + L+ + L +++ LQD S ++ + R + Sbjct: 1350 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409 Query: 636 YLVSRAQEALDAVSTLEEGHAQYLTSLAD-----------ASALVAALTRFSHLAADTII 684 L + +E A LE+ + L D S L +F L A+ Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE--- 1466 Query: 685 NGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQ-QALRHMQAS--LVRTPLQGIL 741 +S A D DR RE +AL L L++ +A ++ + +++ ++ ++ Sbjct: 1467 EKNISSKYA--DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524 Query: 742 ----QLGQ-----ELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHAS 792 +G+ E ++L+ + EE+ ++ E+ A EDA R+E M + Sbjct: 1525 SSKDDVGKNVHELEKSKRALETQMEEMKTQLE-ELEDELQATEDAKLRLEVNMQALK--- 1580 Query: 793 SGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGL 852 + ++ R + + R L T L+ E + AA +++ Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA 1640 Query: 853 ISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHL 912 SA K QL + ++ + E+ EI A+ + ++ KA L Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKE----NEKKAKSLEADL 1696 Query: 913 SRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEK 972 +LQE ERA K E++ + SG + ++ +K+ +E R+ +LE+ Sbjct: 1697 MQLQE-DLAAAERARKQADLEK---EELAEELASSLSGRNALQDEKRRLE--ARIAQLEE 1750 Query: 973 TLEAERMRLGELRKQHYVLAGASGSPGEEVAIRPSTAPRSVTTKK 1017 LE E+ + + + + E+A STA ++ + ++ Sbjct: 1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1795 Score = 74.7 bits (182), Expect = 4e-13 Identities = 72/286 (25%), Positives = 133/286 (46%), Gaps = 32/286 (11%) Query: 332 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNE- 390 RD Q E +R+++ E E + ++ A + LEG+L++ Q A+ E Sbjct: 1590 RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1649 Query: 391 ---QLRHELAQLRAAQLEGERSQGLREEA-------ERKASATEARYNKLKEKHSELVHV 440 QLR AQ++ Q E E ++ R+E E+KA + EA +L+E + Sbjct: 1650 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA---- 1705 Query: 441 HAELLRKNADTAKQ---------LTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKS 491 AE RK AD K+ L+ Q+E R++ ++A Q+E+ E + +E S Sbjct: 1706 -AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA-QLEEELEEEQGNMEAMS 1763 Query: 492 DQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLL 551 D++ K ++ E + ELA + E ++ +L + L ++ + GAV+ + + Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1823 Query: 552 AAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLL 597 AA EA +++ +++ QE E Q + +++ L++ LL Sbjct: 1824 AA------LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1863 Score = 65.5 bits (158), Expect = 3e-10 Identities = 146/748 (19%), Positives = 275/748 (36%), Gaps = 115/748 (15%) Query: 332 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLK-----SQVNALEGELEEQRKQKQKAL 386 + LQ E K +ML E + + EA R QL+ +++ LE E+ Q K Sbjct: 946 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005 Query: 387 VDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLR 446 + + L ++ L + L EE E+ + T KLK KH ++ L+ Sbjct: 1006 KERKLLEERISDL---------TTNLAEEEEKAKNLT-----KLKNKHESMISELEVRLK 1051 Query: 447 KNADTAKQLTVTQQS---------------QEEVARVKEQLAFQVEQV------------ 479 K + ++L ++ Q ++A +K QLA + E++ Sbjct: 1052 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 1111 Query: 480 -----------------------------KRESELKLEEKSDQLEKLKRELEAKAGELAR 510 + ++E + + ++LE LK ELE A Sbjct: 1112 QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT 1171 Query: 511 AQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREA----DLLAAQSLVRETEAALSR 566 QE + EQ + L LD + +A +RQ+ A +L + +A L + Sbjct: 1172 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231 Query: 567 EQQRSSQEQGELQG--RLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDD 624 +Q +E +L G R+ + QE +++ L+ Q L+ ++ + A ++L+D Sbjct: 1232 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG----ERARAELND 1287 Query: 625 PLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTII 684 +H + + + + EA L + A + L D L+ TR L T + Sbjct: 1288 KVH-KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-QKLNVSTKL 1345 Query: 685 NGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLG 744 + D D ++ + L QL D + AS V +G + Sbjct: 1346 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1405 Query: 745 QELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERIL 804 +E+ ++L + EE A DK + ++ + D+ NQ + S+ LE +R Sbjct: 1406 KEI--ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN---LEKKQR-- 1458 Query: 805 NSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGAT 864 K +LL K E R A +E K L A + A Sbjct: 1459 -------KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE-----AK 1506 Query: 865 QLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVN- 923 + +E +K++ + E+L+ ++ + +L + + + ++L+E + Sbjct: 1507 EELERTNKML--KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1564 Query: 924 ------ERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAE 977 N+ A + ++ RD + ++ + E ET++ ++ L A Sbjct: 1565 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAA 1624 Query: 978 RMRLGELRKQHYVLAGASGSPGEEVAIR 1005 + E + L S G E AI+ Sbjct: 1625 AKKKLEGDLKDLELQADSAIKGREEAIK 1652 Score = 64.7 bits (156), Expect = 4e-10 Identities = 143/728 (19%), Positives = 303/728 (41%), Gaps = 99/728 (13%) Query: 334 LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 393 LQ+ + E++ EL+K K Q+ +LK ++ +L E++ Q+ L +L Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELY 910 Query: 394 HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 453 E ++R R ++E E EAR + +++ +L ++ ++ D + Sbjct: 911 AEAEEMRV------RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964 Query: 454 QLTVTQQSQEEVARVKEQLAFQVEQVKRESELK--------LEEKSDQLEKLKRELEAKA 505 QL +EE AR K Q+E+V E+++K +++++++L K ++ LE + Sbjct: 965 QL-----EEEEAARQK----LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1015 Query: 506 GE----LARAQEALSHTEQSK-------SELSSRLDTLSAEKDALSGAVRQREADLLAAQ 554 + LA +E + + K SEL RL + L R+ E D Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075 Query: 555 SLVRETEAALSREQQRSSQEQGELQGRLA----ERESQEQGLR------------QRLLD 598 + + +A ++ + + ++++ ELQ LA E + L+ Q LD Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135 Query: 599 EQFAVLRGAAAEAAGI---LQDAVSKLDDPLHLRCT-----SSPDYLVSRAQEALDAVST 650 + A A + + L+ ++L+D L T + + V+ ++ALD + Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195 Query: 651 LEEGHAQYLTS--LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLI---DTC 705 E Q + L L +F A+ + T D A L Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN-LDKNKQTLEKENADLAGELRVLGQAK 1254 Query: 706 RECGARALELMGQLQDQQALRHMQASLVRTPLQG-ILQLGQELKPKSLDVRQEELGAV-V 763 +E + +L Q+Q+ Q+ + R L + +L E++ + + + E A+ + Sbjct: 1255 QEVEHKKKKLEAQVQELQS-KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1313 Query: 764 DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNER--ILNSCTDLMKAIRLLVTTS 821 K++A+ S+ ++D +++ Q + S+ ++ ER + + + M+A + L Sbjct: 1314 AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1373 Query: 822 TSLQKEIVESGRG----AATQQEFYAKNSRWTEGLISAS-----KAVGWG-----ATQLV 867 ++L ++ +S + A+T + R+ + + + + KA + +L Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1433 Query: 868 EAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAA 927 + D +V+ +L+ + QL+A K ++K++ R + +R E+ Sbjct: 1434 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR---EKET 1490 Query: 928 NVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQV--------RVLELEKTLEAERM 979 ++ ++ +E +E ++ ++ + K+ K EME V V ELEK+ A Sbjct: 1491 KALSLARALEEALEAKEELERTN----KMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546 Query: 980 RLGELRKQ 987 ++ E++ Q Sbjct: 1547 QMEEMKTQ 1554 Score = 63.5 bits (153), Expect = 1e-09 Identities = 126/565 (22%), Positives = 212/565 (37%), Gaps = 106/565 (18%) Query: 335 QIESLKREVEMLR---SELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 391 ++ L+ EVE + +E E ++ + +A L SQ+ + L+E+ +QK Q Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347 Query: 392 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADT 451 L E L+ QL+ E ++ ER S + + K+K + L Sbjct: 1348 LEEERNSLQ-DQLDEEME--AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404 Query: 452 AKQL-TVTQQSQEEVARV-----------------------KEQLAFQVEQVKRE-SELK 486 K++ +TQQ +E+ A + QL +E+ +R+ +L Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464 Query: 487 LEEKS---------DQLEKLKRELEAKAGELARA-QEALSHTEQ---------------- 520 EEK+ D+ E RE E KA LARA +EAL E+ Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524 Query: 521 -SKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQ 579 SK ++ + L K AL + + + L + ++ TE A R + +G+ + Sbjct: 1525 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1584 Query: 580 GRLAERESQEQGLR---QRLLDE----------QFAVLRGAAAEAAGILQDAVSKLDDPL 626 L R+ Q + R QR L E Q A+ A + G L+D + D + Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644 Query: 627 HLRCTSSPDYLVSRAQ------EALDAVSTLEEGHAQYLTSLADASALVAALTRF----- 675 R + +AQ E DA ++ +E A + A +L A L + Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1704 Query: 676 ----SHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQAS 731 + AD A + + L D R AR +L +L+++Q + Sbjct: 1705 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1764 Query: 732 LVRTPLQGILQLGQEL-------------------KPKSLDVRQEELGAVVDKEMAATSA 772 VR Q QL EL + K L + E+ V + +T A Sbjct: 1765 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1824 Query: 773 AIEDAVRRIEDMMNQ-ARHASSGVK 796 A+E + ++E+ + Q AR + K Sbjct: 1825 ALEAKIAQLEEQVEQEAREKQAATK 1849 Score = 55.8 bits (133), Expect = 2e-07 Identities = 58/226 (25%), Positives = 107/226 (47%), Gaps = 15/226 (6%) Query: 333 DLQIESLKREVEMLRS-----ELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALV 387 DL+ E L E+ S + EK +LEA+ IAQL+ ++ +G +E + +KA Sbjct: 1714 DLEKEELAEELASSLSGRNALQDEKRRLEAR--IAQLEEELEEEQGNMEAMSDRVRKATQ 1771 Query: 388 DNEQLRHELAQLR--AAQLEGERSQGLREEAERKASATE---ARYNKLKEKHSELVHVHA 442 EQL +ELA R A + E R Q R+ E ++ E A +K K + L A Sbjct: 1772 QAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA 1831 Query: 443 ELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESEL---KLEEKSDQLEKLKR 499 +L + A++ +S ++ + +++ QVE ++ +E + E+ + ++++LKR Sbjct: 1832 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1891 Query: 500 ELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQ 545 +LE E R ++ E + + + E +AL +R+ Sbjct: 1892 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1937 >gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo sapiens] Length = 1945 Score = 78.6 bits (192), Expect = 3e-14 Identities = 156/765 (20%), Positives = 314/765 (41%), Gaps = 107/765 (13%) Query: 337 ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKAL--VDNEQLRH 394 E ++E+E L+ +LE + IA L++Q+ L+ +L ++ ++ Q AL +D+E + Sbjct: 1054 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1113 Query: 395 ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 454 A + +LEG S L+E+ + + +A + ++ EL + EL TA Q Sbjct: 1114 NNALKKIRELEGHISD-LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172 Query: 455 LTVTQQSQEEVARVKEQL-------AFQVEQVKRESELKLEEKSDQLEKLKR-------- 499 + + ++EV +K+ L QV++++++ +EE ++QLE+ KR Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232 Query: 500 ------------------------------ELEAKAGELARAQEALSHTEQSKSELSSRL 529 +LEA+ EL Q S E++++EL+ ++ Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL---QSKCSDGERARAELNDKV 1289 Query: 530 DTLSAEKDALSGAVRQREA-------DLLAAQSLVRETEAALSREQQRSSQEQGELQGRL 582 L E ++++G + + E D+ + S +++T+ L E ++ +L+ Sbjct: 1290 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1349 Query: 583 AERESQEQGLRQRL-----LDEQFAVLRGAAAEAAGILQDAVSKLD--DPLHLRCTSSPD 635 ER S + L + + L+ + L +++ LQD S ++ + R + Sbjct: 1350 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409 Query: 636 YLVSRAQEALDAVSTLEEGHAQYLTSLAD-----------ASALVAALTRFSHLAADTII 684 L + +E A LE+ + L D S L +F L A+ Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE--- 1466 Query: 685 NGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQ-QALRHMQAS--LVRTPLQGIL 741 +S A D DR RE +AL L L++ +A ++ + +++ ++ ++ Sbjct: 1467 EKNISSKYA--DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524 Query: 742 ----QLGQ-----ELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHAS 792 +G+ E ++L+ + EE+ ++ E+ A EDA R+E M + Sbjct: 1525 SSKDDVGKNVHELEKSKRALETQMEEMKTQLE-ELEDELQATEDAKLRLEVNMQALK--- 1580 Query: 793 SGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGL 852 + ++ R + + R L T L+ E + AA +++ Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA 1640 Query: 853 ISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHL 912 SA K QL + ++ + E+ EI A+ + ++ KA L Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKE----NEKKAKSLEADL 1696 Query: 913 SRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEK 972 +LQE ERA K E++ + SG + ++ +K+ +E R+ +LE+ Sbjct: 1697 MQLQE-DLAAAERARKQADLEK---EELAEELASSLSGRNALQDEKRRLE--ARIAQLEE 1750 Query: 973 TLEAERMRLGELRKQHYVLAGASGSPGEEVAIRPSTAPRSVTTKK 1017 LE E+ + + + + E+A STA ++ + ++ Sbjct: 1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1795 Score = 74.7 bits (182), Expect = 4e-13 Identities = 72/286 (25%), Positives = 133/286 (46%), Gaps = 32/286 (11%) Query: 332 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNE- 390 RD Q E +R+++ E E + ++ A + LEG+L++ Q A+ E Sbjct: 1590 RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1649 Query: 391 ---QLRHELAQLRAAQLEGERSQGLREEA-------ERKASATEARYNKLKEKHSELVHV 440 QLR AQ++ Q E E ++ R+E E+KA + EA +L+E + Sbjct: 1650 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA---- 1705 Query: 441 HAELLRKNADTAKQ---------LTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKS 491 AE RK AD K+ L+ Q+E R++ ++A Q+E+ E + +E S Sbjct: 1706 -AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA-QLEEELEEEQGNMEAMS 1763 Query: 492 DQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLL 551 D++ K ++ E + ELA + E ++ +L + L ++ + GAV+ + + Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1823 Query: 552 AAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLL 597 AA EA +++ +++ QE E Q + +++ L++ LL Sbjct: 1824 AA------LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1863 Score = 65.5 bits (158), Expect = 3e-10 Identities = 146/748 (19%), Positives = 275/748 (36%), Gaps = 115/748 (15%) Query: 332 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLK-----SQVNALEGELEEQRKQKQKAL 386 + LQ E K +ML E + + EA R QL+ +++ LE E+ Q K Sbjct: 946 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005 Query: 387 VDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLR 446 + + L ++ L + L EE E+ + T KLK KH ++ L+ Sbjct: 1006 KERKLLEERISDL---------TTNLAEEEEKAKNLT-----KLKNKHESMISELEVRLK 1051 Query: 447 KNADTAKQLTVTQQS---------------QEEVARVKEQLAFQVEQV------------ 479 K + ++L ++ Q ++A +K QLA + E++ Sbjct: 1052 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 1111 Query: 480 -----------------------------KRESELKLEEKSDQLEKLKRELEAKAGELAR 510 + ++E + + ++LE LK ELE A Sbjct: 1112 QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT 1171 Query: 511 AQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREA----DLLAAQSLVRETEAALSR 566 QE + EQ + L LD + +A +RQ+ A +L + +A L + Sbjct: 1172 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231 Query: 567 EQQRSSQEQGELQG--RLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDD 624 +Q +E +L G R+ + QE +++ L+ Q L+ ++ + A ++L+D Sbjct: 1232 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG----ERARAELND 1287 Query: 625 PLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTII 684 +H + + + + EA L + A + L D L+ TR L T + Sbjct: 1288 KVH-KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-QKLNVSTKL 1345 Query: 685 NGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLG 744 + D D ++ + L QL D + AS V +G + Sbjct: 1346 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1405 Query: 745 QELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERIL 804 +E+ ++L + EE A DK + ++ + D+ NQ + S+ LE +R Sbjct: 1406 KEI--ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN---LEKKQR-- 1458 Query: 805 NSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGAT 864 K +LL K E R A +E K L A + A Sbjct: 1459 -------KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE-----AK 1506 Query: 865 QLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVN- 923 + +E +K++ + E+L+ ++ + +L + + + ++L+E + Sbjct: 1507 EELERTNKML--KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1564 Query: 924 ------ERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAE 977 N+ A + ++ RD + ++ + E ET++ ++ L A Sbjct: 1565 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAA 1624 Query: 978 RMRLGELRKQHYVLAGASGSPGEEVAIR 1005 + E + L S G E AI+ Sbjct: 1625 AKKKLEGDLKDLELQADSAIKGREEAIK 1652 Score = 64.7 bits (156), Expect = 4e-10 Identities = 143/728 (19%), Positives = 303/728 (41%), Gaps = 99/728 (13%) Query: 334 LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 393 LQ+ + E++ EL+K K Q+ +LK ++ +L E++ Q+ L +L Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELY 910 Query: 394 HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 453 E ++R R ++E E EAR + +++ +L ++ ++ D + Sbjct: 911 AEAEEMRV------RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964 Query: 454 QLTVTQQSQEEVARVKEQLAFQVEQVKRESELK--------LEEKSDQLEKLKRELEAKA 505 QL +EE AR K Q+E+V E+++K +++++++L K ++ LE + Sbjct: 965 QL-----EEEEAARQK----LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1015 Query: 506 GE----LARAQEALSHTEQSK-------SELSSRLDTLSAEKDALSGAVRQREADLLAAQ 554 + LA +E + + K SEL RL + L R+ E D Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075 Query: 555 SLVRETEAALSREQQRSSQEQGELQGRLA----ERESQEQGLR------------QRLLD 598 + + +A ++ + + ++++ ELQ LA E + L+ Q LD Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135 Query: 599 EQFAVLRGAAAEAAGI---LQDAVSKLDDPLHLRCT-----SSPDYLVSRAQEALDAVST 650 + A A + + L+ ++L+D L T + + V+ ++ALD + Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195 Query: 651 LEEGHAQYLTS--LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLI---DTC 705 E Q + L L +F A+ + T D A L Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN-LDKNKQTLEKENADLAGELRVLGQAK 1254 Query: 706 RECGARALELMGQLQDQQALRHMQASLVRTPLQG-ILQLGQELKPKSLDVRQEELGAV-V 763 +E + +L Q+Q+ Q+ + R L + +L E++ + + + E A+ + Sbjct: 1255 QEVEHKKKKLEAQVQELQS-KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1313 Query: 764 DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNER--ILNSCTDLMKAIRLLVTTS 821 K++A+ S+ ++D +++ Q + S+ ++ ER + + + M+A + L Sbjct: 1314 AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1373 Query: 822 TSLQKEIVESGRG----AATQQEFYAKNSRWTEGLISAS-----KAVGWG-----ATQLV 867 ++L ++ +S + A+T + R+ + + + + KA + +L Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1433 Query: 868 EAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAA 927 + D +V+ +L+ + QL+A K ++K++ R + +R E+ Sbjct: 1434 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR---EKET 1490 Query: 928 NVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQV--------RVLELEKTLEAERM 979 ++ ++ +E +E ++ ++ + K+ K EME V V ELEK+ A Sbjct: 1491 KALSLARALEEALEAKEELERTN----KMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546 Query: 980 RLGELRKQ 987 ++ E++ Q Sbjct: 1547 QMEEMKTQ 1554 Score = 63.5 bits (153), Expect = 1e-09 Identities = 126/565 (22%), Positives = 212/565 (37%), Gaps = 106/565 (18%) Query: 335 QIESLKREVEMLR---SELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 391 ++ L+ EVE + +E E ++ + +A L SQ+ + L+E+ +QK Q Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347 Query: 392 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADT 451 L E L+ QL+ E ++ ER S + + K+K + L Sbjct: 1348 LEEERNSLQ-DQLDEEME--AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404 Query: 452 AKQL-TVTQQSQEEVARV-----------------------KEQLAFQVEQVKRE-SELK 486 K++ +TQQ +E+ A + QL +E+ +R+ +L Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464 Query: 487 LEEKS---------DQLEKLKRELEAKAGELARA-QEALSHTEQ---------------- 520 EEK+ D+ E RE E KA LARA +EAL E+ Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524 Query: 521 -SKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQ 579 SK ++ + L K AL + + + L + ++ TE A R + +G+ + Sbjct: 1525 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1584 Query: 580 GRLAERESQEQGLR---QRLLDE----------QFAVLRGAAAEAAGILQDAVSKLDDPL 626 L R+ Q + R QR L E Q A+ A + G L+D + D + Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644 Query: 627 HLRCTSSPDYLVSRAQ------EALDAVSTLEEGHAQYLTSLADASALVAALTRF----- 675 R + +AQ E DA ++ +E A + A +L A L + Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1704 Query: 676 ----SHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQAS 731 + AD A + + L D R AR +L +L+++Q + Sbjct: 1705 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1764 Query: 732 LVRTPLQGILQLGQEL-------------------KPKSLDVRQEELGAVVDKEMAATSA 772 VR Q QL EL + K L + E+ V + +T A Sbjct: 1765 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1824 Query: 773 AIEDAVRRIEDMMNQ-ARHASSGVK 796 A+E + ++E+ + Q AR + K Sbjct: 1825 ALEAKIAQLEEQVEQEAREKQAATK 1849 Score = 51.6 bits (122), Expect = 4e-06 Identities = 63/257 (24%), Positives = 115/257 (44%), Gaps = 37/257 (14%) Query: 333 DLQIESLKREVEMLRS-----ELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALV 387 DL+ E L E+ S + EK +LEA+ IAQL+ ++ +G +E + +KA Sbjct: 1714 DLEKEELAEELASSLSGRNALQDEKRRLEAR--IAQLEEELEEEQGNMEAMSDRVRKATQ 1771 Query: 388 DNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRK 447 EQL +ELA R+ ++++ R++ ER+ KE S+L + + K Sbjct: 1772 QAEQLSNELATERST---AQKNESARQQLERQN----------KELRSKLHEMEGAVKSK 1818 Query: 448 NADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGE 507 T L + ++A+++EQ VEQ RE + + + +KLK L E Sbjct: 1819 FKSTIAAL------EAKIAQLEEQ----VEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1868 Query: 508 LARAQEALSHTEQSKS---ELSSRLDTLSAEKDALSGAVRQREADLLAA----QSLVRET 560 A++ E+ + +L +L+ E ++ R+ + +L A +++ RE Sbjct: 1869 RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1928 Query: 561 EAALSREQQRSSQEQGE 577 A S+ + QE + Sbjct: 1929 NALKSKLRGPPPQETSQ 1945 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.314 0.129 0.355 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 37,170,031 Number of Sequences: 37866 Number of extensions: 1745883 Number of successful extensions: 16886 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 372 Number of HSP's successfully gapped in prelim test: 1081 Number of HSP's that attempted gapping in prelim test: 7385 Number of HSP's gapped (non-prelim): 5280 length of query: 1048 length of database: 18,247,518 effective HSP length: 113 effective length of query: 935 effective length of database: 13,968,660 effective search space: 13060697100 effective search space used: 13060697100 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (22.0 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.