Guide to the Human Genome
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Search of human proteins with 10835143

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|10835143 decay accelerating factor for complement isoform 1
preproprotein [Homo sapiens]
         (381 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|10835143 decay accelerating factor for complement isoform 1 p...   799   0.0  
gi|168693643 decay accelerating factor for complement isoform 2 ...   761   0.0  
gi|86793109 complement receptor 1 isoform S precursor [Homo sapi...   168   7e-42
gi|86793036 complement receptor 1 isoform F precursor [Homo sapi...   168   7e-42
gi|148922949 complement component (3b/4b) receptor 1-like [Homo ...   155   6e-38
gi|4502503 complement component 4 binding protein, alpha chain p...   154   1e-37
gi|42544177 complement component (3d/Epstein Barr virus) recepto...   119   6e-27
gi|54792123 complement component (3d/Epstein Barr virus) recepto...   119   6e-27
gi|148886654 polydom [Homo sapiens]                                   116   3e-26
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap...   108   1e-23
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa...   108   1e-23
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap...   108   1e-23
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]          107   2e-23
gi|27502421 CD46 antigen, complement regulatory protein isoform ...   107   2e-23
gi|27502419 CD46 antigen, complement regulatory protein isoform ...   107   2e-23
gi|27502417 CD46 antigen, complement regulatory protein isoform ...   107   2e-23
gi|27502415 CD46 antigen, complement regulatory protein isoform ...   107   2e-23
gi|27502413 CD46 antigen, complement regulatory protein isoform ...   107   2e-23
gi|27502411 CD46 antigen, complement regulatory protein isoform ...   107   2e-23
gi|27502409 CD46 antigen, complement regulatory protein isoform ...   107   2e-23
gi|27502407 CD46 antigen, complement regulatory protein isoform ...   107   2e-23
gi|27502405 CD46 antigen, complement regulatory protein isoform ...   107   2e-23
gi|27502402 CD46 antigen, complement regulatory protein isoform ...   107   2e-23
gi|24432108 CD46 antigen, complement regulatory protein isoform ...   107   2e-23
gi|27502427 CD46 antigen, complement regulatory protein isoform ...   107   2e-23
gi|27502425 CD46 antigen, complement regulatory protein isoform ...   107   2e-23
gi|27502423 CD46 antigen, complement regulatory protein isoform ...   107   2e-23
gi|166235140 seizure related 6 homolog (mouse)-like 2 isoform 4 ...    97   2e-20
gi|166235138 seizure related 6 homolog (mouse)-like 2 isoform 3 ...    97   2e-20
gi|166235136 seizure related 6 homolog (mouse)-like 2 isoform 2 ...    97   2e-20

>gi|10835143 decay accelerating factor for complement isoform 1
           preproprotein [Homo sapiens]
          Length = 381

 Score =  799 bits (2064), Expect = 0.0
 Identities = 381/381 (100%), Positives = 381/381 (100%)

Query: 1   MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTV 60
           MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTV
Sbjct: 1   MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTV 60

Query: 61  ITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNYFP 120
           ITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNYFP
Sbjct: 61  ITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNYFP 120

Query: 121 VGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGI 180
           VGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGI
Sbjct: 121 VGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGI 180

Query: 181 LFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGER 240
           LFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGER
Sbjct: 181 LFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGER 240

Query: 241 DHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPT 300
           DHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPT
Sbjct: 241 DHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPT 300

Query: 301 TVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVSRTTKHFHETTPNKGSGTTSGTTRLLS 360
           TVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVSRTTKHFHETTPNKGSGTTSGTTRLLS
Sbjct: 301 TVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVSRTTKHFHETTPNKGSGTTSGTTRLLS 360

Query: 361 GHTCFTLTGLLGTLVTMGLLT 381
           GHTCFTLTGLLGTLVTMGLLT
Sbjct: 361 GHTCFTLTGLLGTLVTMGLLT 381


>gi|168693643 decay accelerating factor for complement isoform 2
           precursor [Homo sapiens]
          Length = 440

 Score =  761 bits (1965), Expect = 0.0
 Identities = 363/370 (98%), Positives = 364/370 (98%)

Query: 1   MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTV 60
           MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTV
Sbjct: 1   MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTV 60

Query: 61  ITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNYFP 120
           ITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNYFP
Sbjct: 61  ITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNYFP 120

Query: 121 VGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGI 180
           VGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGI
Sbjct: 121 VGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGI 180

Query: 181 LFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGER 240
           LFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGER
Sbjct: 181 LFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGER 240

Query: 241 DHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPT 300
           DHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPT
Sbjct: 241 DHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPT 300

Query: 301 TVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVSRTTKHFHETTPNKGSGTTSGTTRLLS 360
           TVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVSRTTKHFHETTPNKGSGTTSGTTRLLS
Sbjct: 301 TVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVSRTTKHFHETTPNKGSGTTSGTTRLLS 360

Query: 361 GHTCFTLTGL 370
           G    T  G+
Sbjct: 361 GSRPVTQAGM 370


>gi|86793109 complement receptor 1 isoform S precursor [Homo
           sapiens]
          Length = 2489

 Score =  168 bits (426), Expect = 7e-42
 Identities = 101/268 (37%), Positives = 139/268 (51%), Gaps = 26/268 (9%)

Query: 36  CGLPPDVPNAQPALEGRTSFPEDTVITYKCEE------SFVKIPGEKDSVICLKGSQ--- 86
           C  PP +PN +   +    FP    + Y C+       SF  I GE  ++ C    Q   
Sbjct: 421 CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLI-GES-TIRCTSDPQGNG 478

Query: 87  -WSDIEEFCN--RSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKL 143
            WS     C     C+ P     A LK      + FP+GT ++YECRP Y   P     +
Sbjct: 479 VWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASD-FPIGTSLKYECRPEYYGRPF---SI 534

Query: 144 TCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSF 203
           TCL NL WS+  + CK+KSC  P +  NG + V   I  G+ I++SC TG++L G +S+ 
Sbjct: 535 TCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAE 594

Query: 204 CLISGSSVQWSDPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG------ 256
           C++SG++  WS   P C+ I C  PP I NG  I   R+++ Y   VTY CN G      
Sbjct: 595 CILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKV 654

Query: 257 FTMIGEHSIYCTVNNDE-GEWSGPPPEC 283
           F ++GE SIYCT N+D+ G WSGP P+C
Sbjct: 655 FELVGEPSIYCTSNDDQVGIWSGPAPQC 682



 Score =  168 bits (426), Expect = 7e-42
 Identities = 101/268 (37%), Positives = 139/268 (51%), Gaps = 26/268 (9%)

Query: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEE------SFVKIPGEKDSVICLKGSQ--- 86
            C  PP +PN +   +    FP    + Y C+       SF  I GE  ++ C    Q   
Sbjct: 871  CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLI-GES-TIRCTSDPQGNG 928

Query: 87   -WSDIEEFCN--RSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKL 143
             WS     C     C+ P     A LK      + FP+GT ++YECRP Y   P     +
Sbjct: 929  VWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASD-FPIGTSLKYECRPEYYGRPF---SI 984

Query: 144  TCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSF 203
            TCL NL WS+  + CK+KSC  P +  NG + V   I  G+ I++SC TG++L G +S+ 
Sbjct: 985  TCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAE 1044

Query: 204  CLISGSSVQWSDPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG------ 256
            C++SG++  WS   P C+ I C  PP I NG  I   R+++ Y   VTY CN G      
Sbjct: 1045 CILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKV 1104

Query: 257  FTMIGEHSIYCTVNNDE-GEWSGPPPEC 283
            F ++GE SIYCT N+D+ G WSGP P+C
Sbjct: 1105 FELVGEPSIYCTSNDDQVGIWSGPAPQC 1132



 Score =  168 bits (425), Expect = 8e-42
 Identities = 101/268 (37%), Positives = 139/268 (51%), Gaps = 26/268 (9%)

Query: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEE------SFVKIPGEKDSVICLKGSQ--- 86
            C  PP +PN +   +    FP    + Y C+       SF  I GE  ++ C    Q   
Sbjct: 1321 CPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLI-GES-TIRCTSDPQGNG 1378

Query: 87   -WSDIEEFCN--RSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKL 143
             WS     C     C+ P     A LK      + FP+GT ++YECRP Y   P     +
Sbjct: 1379 VWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASD-FPIGTSLKYECRPEYYGRPF---SI 1434

Query: 144  TCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSF 203
            TCL NL WS+  + CK+KSC  P +  NG + V   I  G+ I++SC TG++L G +S+ 
Sbjct: 1435 TCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAE 1494

Query: 204  CLISGSSVQWSDPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG------ 256
            C++SG++  WS   P C+ I C  PP I NG  I   R+++ Y   VTY CN G      
Sbjct: 1495 CILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKV 1554

Query: 257  FTMIGEHSIYCTVNNDE-GEWSGPPPEC 283
            F ++GE SIYCT N+D+ G WSGP P+C
Sbjct: 1555 FELVGEPSIYCTSNDDQVGIWSGPAPQC 1582



 Score =  162 bits (410), Expect = 5e-40
 Identities = 80/173 (46%), Positives = 106/173 (61%), Gaps = 11/173 (6%)

Query: 119 FPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPG 178
           FP+GT + YECRPGY   P     + CL+N  W+ A + C++KSC NP +  NG + V  
Sbjct: 63  FPIGTYLNYECRPGYSGRPF---SIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIK 119

Query: 179 GILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNG-IIQ 237
           GI FG+ I +SC  GY+L GS+S+ C+ISG +V W +  P C  I C  PP I NG  I 
Sbjct: 120 GIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFIS 179

Query: 238 GERDHYGYRQSVTYACNKG------FTMIGEHSIYCTVNNDE-GEWSGPPPEC 283
             R+++ Y   VTY CN G      F ++GE SIYCT N+D+ G WSGP P+C
Sbjct: 180 TNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC 232



 Score =  155 bits (391), Expect = 7e-38
 Identities = 95/270 (35%), Positives = 131/270 (48%), Gaps = 27/270 (10%)

Query: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEES-----FVKIPGEKDSVICLKGSQ---- 86
            C  PP + N +         P    I+Y C+          + GE  ++ C         
Sbjct: 1771 CPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGES-TIRCTSDPHGNGV 1829

Query: 87   WSDIEEFCNRS-----CEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSP 141
            WS     C  S     C+ P +   AS   P I    FPVGT + YECRPGY  +     
Sbjct: 1830 WSSPAPRCELSVRAGHCKTPEQFPFASPTIP-INDFEFPVGTSLNYECRPGYFGKMF--- 1885

Query: 142  KLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTS 201
             ++CL+NL WS+  + C++KSC  P E  NG + +     FG+T+++SCN G++L GS S
Sbjct: 1886 SISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPS 1945

Query: 202  SFCLISGSSVQWSDPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG---- 256
            + CL+SG++V W    P C  I C  PP I NG      R  +     VTY C+ G    
Sbjct: 1946 TTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGE 2005

Query: 257  --FTMIGEHSIYCTVNNDE-GEWSGPPPEC 283
              F ++GE SIYCT  +D+ G WS PPP C
Sbjct: 2006 QLFELVGERSIYCTSKDDQVGVWSSPPPRC 2035



 Score =  136 bits (342), Expect = 4e-32
 Identities = 80/254 (31%), Positives = 131/254 (51%), Gaps = 15/254 (5%)

Query: 39  PPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSC 98
           PP+V N     + R+ F  + V+ ++C+  FV + G +  V C   ++W      C+R C
Sbjct: 240 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFV-MKGPR-RVKCQALNKWEPELPSCSRVC 297

Query: 99  EVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFC 158
           + P  +  A   Q    ++ F  G  V Y C PGY    + S  + C     WS A   C
Sbjct: 298 QPPPDVLHAERTQR--DKDNFSPGQEVFYSCEPGYDLRGAAS--MRCTPQGDWSPAAPTC 353

Query: 159 KKKSCPN-PGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPL 217
           + KSC +  G++ NG++  P  +  GA + F C+ G++L GS++S+C+++G    W+  +
Sbjct: 354 EVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSV 413

Query: 218 PECREIYCPAPPQIDNGIIQGE-RDHYGYRQSVTYACN------KGFTMIGEHSIYCTVN 270
           P C +I+CP+PP I NG   G+  + + + ++V Y C+        F +IGE +I CT +
Sbjct: 414 PVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSD 473

Query: 271 -NDEGEWSGPPPEC 283
               G WS P P C
Sbjct: 474 PQGNGVWSSPAPRC 487



 Score =  136 bits (342), Expect = 4e-32
 Identities = 80/254 (31%), Positives = 131/254 (51%), Gaps = 15/254 (5%)

Query: 39  PPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSC 98
           PP+V N     + R+ F  + V+ ++C+  FV + G +  V C   ++W      C+R C
Sbjct: 690 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFV-MKGPR-RVKCQALNKWEPELPSCSRVC 747

Query: 99  EVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFC 158
           + P  +  A   Q    ++ F  G  V Y C PGY    + S  + C     WS A   C
Sbjct: 748 QPPPDVLHAERTQR--DKDNFSPGQEVFYSCEPGYDLRGAAS--MRCTPQGDWSPAAPTC 803

Query: 159 KKKSCPN-PGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPL 217
           + KSC +  G++ NG++  P  +  GA + F C+ G++L GS++S+C+++G    W+  +
Sbjct: 804 EVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSV 863

Query: 218 PECREIYCPAPPQIDNGIIQGE-RDHYGYRQSVTYACN------KGFTMIGEHSIYCTVN 270
           P C +I+CP+PP I NG   G+  + + + ++V Y C+        F +IGE +I CT +
Sbjct: 864 PVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSD 923

Query: 271 -NDEGEWSGPPPEC 283
               G WS P P C
Sbjct: 924 PQGNGVWSSPAPRC 937



 Score =  136 bits (342), Expect = 4e-32
 Identities = 80/254 (31%), Positives = 131/254 (51%), Gaps = 15/254 (5%)

Query: 39   PPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSC 98
            PP+V N     + R+ F  + V+ ++C+  FV + G +  V C   ++W      C+R C
Sbjct: 1140 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFV-MKGPR-RVKCQALNKWEPELPSCSRVC 1197

Query: 99   EVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFC 158
            + P  +  A   Q    ++ F  G  V Y C PGY    + S  + C     WS A   C
Sbjct: 1198 QPPPDVLHAERTQR--DKDNFSPGQEVFYSCEPGYDLRGAAS--MRCTPQGDWSPAAPTC 1253

Query: 159  KKKSCPN-PGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPL 217
            + KSC +  G++ NG++  P  +  GA + F C+ G++L GS++S+C+++G    W+  +
Sbjct: 1254 EVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSV 1313

Query: 218  PECREIYCPAPPQIDNGIIQGE-RDHYGYRQSVTYACN------KGFTMIGEHSIYCTVN 270
            P C +I+CP+PP I NG   G+  + + + ++V Y C+        F +IGE +I CT +
Sbjct: 1314 PVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSD 1373

Query: 271  -NDEGEWSGPPPEC 283
                G WS P P C
Sbjct: 1374 PQGNGVWSSPAPRC 1387



 Score =  127 bits (320), Expect = 1e-29
 Identities = 78/253 (30%), Positives = 120/253 (47%), Gaps = 15/253 (5%)

Query: 40   PDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCE 99
            P+V NA      R+ F    +I ++C+  FV +     +V C    +W      C+R C+
Sbjct: 2044 PEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSH--TVQCQTNGRWGPKLPHCSRVCQ 2101

Query: 100  VPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCK 159
             P  +        +  Q+ F  G  V Y C P Y    + S  L C     WS     C 
Sbjct: 2102 PPPEILHGEHTLSH--QDNFSPGQEVFYSCEPSYDLRGAAS--LHCTPQGDWSPEAPRCT 2157

Query: 160  KKSCPN-PGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLP 218
             KSC +  G++ +G++ +P  +  GA +SF C+ G++L G ++S C+++G    W+  +P
Sbjct: 2158 VKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVP 2217

Query: 219  ECREIYCPAPPQIDNGIIQGER-DHYGYRQSVTYACN------KGFTMIGEHSIYCTVN- 270
             C +I+CP PP I NG   G       Y + ++YAC+        F +IGE SI CT + 
Sbjct: 2218 VCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDP 2277

Query: 271  NDEGEWSGPPPEC 283
               G WS P P C
Sbjct: 2278 QGNGVWSSPAPRC 2290



 Score =  125 bits (313), Expect = 8e-29
 Identities = 79/254 (31%), Positives = 123/254 (48%), Gaps = 15/254 (5%)

Query: 39   PPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSC 98
            PP+V N     + R+ F  + V+ ++C+  FV + G +  V C   ++W      C+R C
Sbjct: 1590 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFV-MKGPR-RVKCQALNKWEPELPSCSRVC 1647

Query: 99   EVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFC 158
            + P  +        +  Q+ F  G  V Y C PGY    + S  L C     WS     C
Sbjct: 1648 QPPPEILHGEHTPSH--QDNFSPGQEVFYSCEPGYDLRGAAS--LHCTPQGDWSPEAPRC 1703

Query: 159  KKKSCPN-PGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPL 217
              KSC +  G++ +G++  P  +  GA +SF C+ G++L GS+ S C++ G    W++ +
Sbjct: 1704 AVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSV 1763

Query: 218  PECREIYCPAPPQIDNGIIQG-ERDHYGYRQSVTYACN------KGFTMIGEHSIYCTVN 270
            P C  I+CP PP I NG   G       Y + ++Y C+        F +IGE +I CT +
Sbjct: 1764 PVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSD 1823

Query: 271  -NDEGEWSGPPPEC 283
             +  G WS P P C
Sbjct: 1824 PHGNGVWSSPAPRC 1837



 Score =  115 bits (288), Expect = 7e-26
 Identities = 84/291 (28%), Positives = 125/291 (42%), Gaps = 30/291 (10%)

Query: 21  LLLLVLLCLPAVWGDCGLPPDVPNAQPA-LEGRTSFPEDTVITYKCEESFVKIPGEKDSV 79
           L ++VLL LP  WG C  P  +P A+P  L     FP  T + Y+C   +    G   S+
Sbjct: 28  LAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGY---SGRPFSI 84

Query: 80  ICLKGSQWSDIEEFCNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPS 138
           ICLK S W+  ++ C R SC  P    +  +   ++ +     G+ ++Y C  GYR   S
Sbjct: 85  ICLKNSVWTGAKDRCRRKSCRNPPDPVNGMV---HVIKG-IQFGSQIKYSCTKGYRLIGS 140

Query: 139 LSPKLTCL---QNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPG--GILFGATISFSCNTG 193
            S   TC+     + W      C +  C  P  I NG           +G+ +++ CN G
Sbjct: 141 SS--ATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPG 198

Query: 194 ------YKLFGSTSSFCLISGSSVQ-WSDPLPECREIYCPAPPQIDNGI-IQGERDHYGY 245
                 ++L G  S +C  +   V  WS P P+C       PP ++NGI +   R  +  
Sbjct: 199 SGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSL 258

Query: 246 RQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTV 296
            + V + C  GF M G   + C   N   +W    P C   S   + PP V
Sbjct: 259 NEVVEFRCQPGFVMKGPRRVKCQALN---KWEPELPSC---SRVCQPPPDV 303



 Score =  114 bits (284), Expect = 2e-25
 Identities = 80/278 (28%), Positives = 115/278 (41%), Gaps = 30/278 (10%)

Query: 34   GDCGLPPDVPNAQPALE-GRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEE 92
            G C  P   P A P +      FP  T + Y+C   +    G+  S+ CL+   WS +E+
Sbjct: 1844 GHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYF---GKMFSISCLENLVWSSVED 1900

Query: 93   FCNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCL---QN 148
             C R SC  P    +  +     TQ     G+ V Y C  G+R   S  P  TCL    N
Sbjct: 1901 NCRRKSCGPPPEPFNGMVHINTDTQ----FGSTVNYSCNEGFRLIGS--PSTTCLVSGNN 1954

Query: 149  LKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILF--GATISFSCNTG------YKLFGST 200
            + W      C+  SC  P  I NG         F  G  +++ C+TG      ++L G  
Sbjct: 1955 VTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGER 2014

Query: 201  SSFCLISGSSVQ-WSDPLPECREIYCPAPPQIDNGI-IQGERDHYGYRQSVTYACNKGFT 258
            S +C      V  WS P P C        P+++N I + G R  +   + + + C  GF 
Sbjct: 2015 SIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFV 2074

Query: 259  MIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTV 296
            M+G H++ C  N   G W    P C   S   + PP +
Sbjct: 2075 MVGSHTVQCQTN---GRWGPKLPHC---SRVCQPPPEI 2106



 Score = 94.0 bits (232), Expect = 2e-19
 Identities = 78/266 (29%), Positives = 122/266 (45%), Gaps = 27/266 (10%)

Query: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCN 95
            C  PP++ + +  L  + +F     + Y CE S+  + G   S+ C     WS     C 
Sbjct: 2100 CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSY-DLRGAA-SLHCTPQGDWSPEAPRCT 2157

Query: 96   -RSC-EVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYR-REPSLSPKLTCLQNLKWS 152
             +SC +   +L    +  P   Q    +G  V + C  G+R +  S S  +       W+
Sbjct: 2158 VKSCDDFLGQLPHGRVLLPLNLQ----LGAKVSFVCDEGFRLKGRSASHCVLAGMKALWN 2213

Query: 153  TAVEFCKKKSCPNPGEIRNGQ-IDVP-GGILFGATISFSCNT------GYKLFGSTSSFC 204
            ++V  C++  CPNP  I NG+    P G I +G  IS++C+T       + L G +S  C
Sbjct: 2214 SSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRC 2273

Query: 205  LI--SGSSVQWSDPLPECR---EIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKGFT 258
                 G+ V WS P P C       CP PP+I NG  I G    Y    +++Y C+ G+ 
Sbjct: 2274 TSDPQGNGV-WSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYL 2332

Query: 259  MIGEHSIYCTVNNDEGEWSGPPPECR 284
            ++G+  I+CT   D+G WS     C+
Sbjct: 2333 LVGKGFIFCT---DQGIWSQLDHYCK 2355



 Score = 90.1 bits (222), Expect = 3e-18
 Identities = 75/278 (26%), Positives = 113/278 (40%), Gaps = 26/278 (9%)

Query: 32  VWGDCGLPPDVPNAQPALEGRTS-FPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDI 90
           + G C  P     A+   +   S FP  T + Y+C   +    G   S+ CL    WS  
Sbjct: 489 ILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY---GRPFSITCLDNLVWSSP 545

Query: 91  EEFCNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNL 149
           ++ C R SC+ P    +  +    IT     VG+ + Y C  G+R     S +     N 
Sbjct: 546 KDVCKRKSCKTPPDPVNGMVH--VITD--IQVGSRINYSCTTGHRLIGHSSAECILSGNA 601

Query: 150 K-WSTAVEFCKKKSCPNPGEIRNGQIDVPG--GILFGATISFSCNTG------YKLFGST 200
             WST    C++  C  P  I NG           +G+ +++ CN G      ++L G  
Sbjct: 602 AHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEP 661

Query: 201 SSFCLISGSSVQ-WSDPLPECREIYCPAPPQIDNGIIQGE-RDHYGYRQSVTYACNKGFT 258
           S +C  +   V  WS P P+C       PP ++NGI+  + R  +   + V + C  GF 
Sbjct: 662 SIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFV 721

Query: 259 MIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTV 296
           M G   + C   N   +W    P C   S   + PP V
Sbjct: 722 MKGPRRVKCQALN---KWEPELPSC---SRVCQPPPDV 753



 Score = 90.1 bits (222), Expect = 3e-18
 Identities = 75/278 (26%), Positives = 113/278 (40%), Gaps = 26/278 (9%)

Query: 32   VWGDCGLPPDVPNAQPALEGRTS-FPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDI 90
            + G C  P     A+   +   S FP  T + Y+C   +    G   S+ CL    WS  
Sbjct: 939  ILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY---GRPFSITCLDNLVWSSP 995

Query: 91   EEFCNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNL 149
            ++ C R SC+ P    +  +    IT     VG+ + Y C  G+R     S +     N 
Sbjct: 996  KDVCKRKSCKTPPDPVNGMVH--VITD--IQVGSRINYSCTTGHRLIGHSSAECILSGNA 1051

Query: 150  K-WSTAVEFCKKKSCPNPGEIRNGQIDVPG--GILFGATISFSCNTG------YKLFGST 200
              WST    C++  C  P  I NG           +G+ +++ CN G      ++L G  
Sbjct: 1052 AHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEP 1111

Query: 201  SSFCLISGSSVQ-WSDPLPECREIYCPAPPQIDNGIIQGE-RDHYGYRQSVTYACNKGFT 258
            S +C  +   V  WS P P+C       PP ++NGI+  + R  +   + V + C  GF 
Sbjct: 1112 SIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFV 1171

Query: 259  MIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTV 296
            M G   + C   N   +W    P C   S   + PP V
Sbjct: 1172 MKGPRRVKCQALN---KWEPELPSC---SRVCQPPPDV 1203



 Score = 89.7 bits (221), Expect = 4e-18
 Identities = 74/278 (26%), Positives = 113/278 (40%), Gaps = 26/278 (9%)

Query: 32   VWGDCGLPPDVPNAQPALEGRTS-FPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDI 90
            + G C  P     A+   +   S FP  T + Y+C   +    G   S+ CL    WS  
Sbjct: 1389 ILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY---GRPFSITCLDNLVWSSP 1445

Query: 91   EEFCNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNL 149
            ++ C R SC+ P    +  +    IT     VG+ + Y C  G+R     S +     N 
Sbjct: 1446 KDVCKRKSCKTPPDPVNGMVH--VITD--IQVGSRINYSCTTGHRLIGHSSAECILSGNT 1501

Query: 150  K-WSTAVEFCKKKSCPNPGEIRNGQIDVPG--GILFGATISFSCNTG------YKLFGST 200
              WST    C++  C  P  I NG           +G+ +++ CN G      ++L G  
Sbjct: 1502 AHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEP 1561

Query: 201  SSFCLISGSSVQ-WSDPLPECREIYCPAPPQIDNGIIQGE-RDHYGYRQSVTYACNKGFT 258
            S +C  +   V  WS P P+C       PP ++NGI+  + R  +   + V + C  GF 
Sbjct: 1562 SIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFV 1621

Query: 259  MIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTV 296
            M G   + C   N   +W    P C   S   + PP +
Sbjct: 1622 MKGPRRVKCQALN---KWEPELPSC---SRVCQPPPEI 1653



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 74/267 (27%), Positives = 109/267 (40%), Gaps = 28/267 (10%)

Query: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQ--WSDIEEF 93
            CG PP+  N    +   T F   + + Y C E F ++ G   +   + G+   W      
Sbjct: 1907 CGPPPEPFNGMVHINTDTQF--GSTVNYSCNEGF-RLIGSPSTTCLVSGNNVTWDKKAPI 1963

Query: 94   CNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLS----PKLTCL-- 146
            C   SCE P  +++        T   F  GTVV Y+C  G   E          + C   
Sbjct: 1964 CEIISCEPPPTISNGDFYSNNRTS--FHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSK 2021

Query: 147  --QNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGAT---ISFSCNTGYKLFGSTS 201
              Q   WS+    C   +     E+ N  I VPG   F      I F C  G+ + GS +
Sbjct: 2022 DDQVGVWSSPPPRCISTNKCTAPEVENA-IRVPGNRSFFTLTEIIRFRCQPGFVMVGSHT 2080

Query: 202  SFCLISGSSVQWSDPLPECREIYCPAPPQIDNGI-IQGERDHYGYRQSVTYACNKGFTMI 260
              C  +G   +W   LP C  + C  PP+I +G      +D++   Q V Y+C   + + 
Sbjct: 2081 VQCQTNG---RWGPKLPHCSRV-CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLR 2136

Query: 261  GEHSIYCTVNNDEGEWSGPPPECRGKS 287
            G  S++CT    +G+WS   P C  KS
Sbjct: 2137 GAASLHCT---PQGDWSPEAPRCTVKS 2160



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 78/288 (27%), Positives = 123/288 (42%), Gaps = 41/288 (14%)

Query: 29  LPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWS 88
           LP+    C  PPDV +A+     + +F     + Y CE  +  + G   S+ C     WS
Sbjct: 290 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY-DLRGAA-SMRCTPQGDWS 347

Query: 89  DIEEFCN-RSCE--VPTRLNSASLKQPYITQNYFPV----GTVVEYECRPGYRREPSLSP 141
                C  +SC+  +   LN   L         FPV    G  V++ C  G++ + S + 
Sbjct: 348 PAAPTCEVKSCDDFMGQLLNGRVL---------FPVNLQLGAKVDFVCDEGFQLKGSSAS 398

Query: 142 --KLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQ-IDVPGGIL-FGATISFSCN------ 191
              L  +++L W+++V  C++  CP+P  I NG+    P  +  FG T++++C+      
Sbjct: 399 YCVLAGMESL-WNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRG 457

Query: 192 TGYKLFGSTSSFCLI--SGSSVQWSDPLPECREI-YCPAPPQIDNGII--QGERDHYGYR 246
           T + L G ++  C     G+ V WS P P C  + +C AP       +  Q     +   
Sbjct: 458 TSFDLIGESTIRCTSDPQGNGV-WSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIG 516

Query: 247 QSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPP 294
            S+ Y C   +      SI C    D   WS P   C+ KS   K PP
Sbjct: 517 TSLKYECRPEY-YGRPFSITCL---DNLVWSSPKDVCKRKS--CKTPP 558



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 78/288 (27%), Positives = 123/288 (42%), Gaps = 41/288 (14%)

Query: 29   LPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWS 88
            LP+    C  PPDV +A+     + +F     + Y CE  +  + G   S+ C     WS
Sbjct: 740  LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY-DLRGAA-SMRCTPQGDWS 797

Query: 89   DIEEFCN-RSCE--VPTRLNSASLKQPYITQNYFPV----GTVVEYECRPGYRREPSLSP 141
                 C  +SC+  +   LN   L         FPV    G  V++ C  G++ + S + 
Sbjct: 798  PAAPTCEVKSCDDFMGQLLNGRVL---------FPVNLQLGAKVDFVCDEGFQLKGSSAS 848

Query: 142  --KLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQ-IDVPGGIL-FGATISFSCN------ 191
               L  +++L W+++V  C++  CP+P  I NG+    P  +  FG T++++C+      
Sbjct: 849  YCVLAGMESL-WNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRG 907

Query: 192  TGYKLFGSTSSFCLI--SGSSVQWSDPLPECREI-YCPAPPQIDNGII--QGERDHYGYR 246
            T + L G ++  C     G+ V WS P P C  + +C AP       +  Q     +   
Sbjct: 908  TSFDLIGESTIRCTSDPQGNGV-WSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIG 966

Query: 247  QSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPP 294
             S+ Y C   +      SI C    D   WS P   C+ KS   K PP
Sbjct: 967  TSLKYECRPEY-YGRPFSITCL---DNLVWSSPKDVCKRKS--CKTPP 1008



 Score = 65.9 bits (159), Expect = 6e-11
 Identities = 77/288 (26%), Positives = 122/288 (42%), Gaps = 41/288 (14%)

Query: 29   LPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWS 88
            LP+    C  PPDV +A+     + +F     + Y CE  +  + G   S+ C     WS
Sbjct: 1190 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY-DLRGAA-SMRCTPQGDWS 1247

Query: 89   DIEEFCN-RSCE--VPTRLNSASLKQPYITQNYFPV----GTVVEYECRPGYRREPSLSP 141
                 C  +SC+  +   LN   L         FPV    G  V++ C  G++ + S + 
Sbjct: 1248 PAAPTCEVKSCDDFMGQLLNGRVL---------FPVNLQLGAKVDFVCDEGFQLKGSSAS 1298

Query: 142  --KLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQ-IDVPGGIL-FGATISFSCN------ 191
               L  +++L W+++V  C++  CP+P  I NG+    P  +  FG  ++++C+      
Sbjct: 1299 YCVLAGMESL-WNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRG 1357

Query: 192  TGYKLFGSTSSFCLI--SGSSVQWSDPLPECREI-YCPAPPQIDNGII--QGERDHYGYR 246
            T + L G ++  C     G+ V WS P P C  + +C AP       +  Q     +   
Sbjct: 1358 TSFDLIGESTIRCTSDPQGNGV-WSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIG 1416

Query: 247  QSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPP 294
             S+ Y C   +      SI C    D   WS P   C+ KS   K PP
Sbjct: 1417 TSLKYECRPEY-YGRPFSITCL---DNLVWSSPKDVCKRKS--CKTPP 1458



 Score = 65.5 bits (158), Expect = 8e-11
 Identities = 67/269 (24%), Positives = 101/269 (37%), Gaps = 33/269 (12%)

Query: 49  LEGRTSFPED----TVITYKCEESFVKIPGEKDSVICLKG--SQWSDIEEFCNRS-CEVP 101
           L GR  FP +      + + C+E F ++ G   S   L G  S W+     C +  C  P
Sbjct: 366 LNGRVLFPVNLQLGAKVDFVCDEGF-QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSP 424

Query: 102 TRL-NSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLS----PKLTCLQ----NLKWS 152
             + N     +P      FP G  V Y C P   R  S        + C      N  WS
Sbjct: 425 PVIPNGRHTGKPL---EVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 481

Query: 153 TAVEFCKKKS-CPNPGEIRNGQIDVP---GGILFGATISFSCNTGYKLFGSTSSFCLISG 208
           +    C     C  P      ++           G ++ + C   Y  +G   S   +  
Sbjct: 482 SPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY--YGRPFSITCLD- 538

Query: 209 SSVQWSDPLPECREIYCPAPPQIDNGIIQGERD-HYGYRQSVTYACNKGFTMIGEHSIYC 267
            ++ WS P   C+   C  PP   NG++    D   G R  + Y+C  G  +IG  S  C
Sbjct: 539 -NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSR--INYSCTTGHRLIGHSSAEC 595

Query: 268 TVNNDEGEWSGPPPECRGKSLTSKVPPTV 296
            ++ +   WS  PP C  + +   +PPT+
Sbjct: 596 ILSGNAAHWSTKPPIC--QRIPCGLPPTI 622



 Score = 65.5 bits (158), Expect = 8e-11
 Identities = 67/269 (24%), Positives = 101/269 (37%), Gaps = 33/269 (12%)

Query: 49   LEGRTSFPED----TVITYKCEESFVKIPGEKDSVICLKG--SQWSDIEEFCNRS-CEVP 101
            L GR  FP +      + + C+E F ++ G   S   L G  S W+     C +  C  P
Sbjct: 816  LNGRVLFPVNLQLGAKVDFVCDEGF-QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSP 874

Query: 102  TRL-NSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLS----PKLTCLQ----NLKWS 152
              + N     +P      FP G  V Y C P   R  S        + C      N  WS
Sbjct: 875  PVIPNGRHTGKPL---EVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 931

Query: 153  TAVEFCKKKS-CPNPGEIRNGQIDVP---GGILFGATISFSCNTGYKLFGSTSSFCLISG 208
            +    C     C  P      ++           G ++ + C   Y  +G   S   +  
Sbjct: 932  SPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY--YGRPFSITCLD- 988

Query: 209  SSVQWSDPLPECREIYCPAPPQIDNGIIQGERD-HYGYRQSVTYACNKGFTMIGEHSIYC 267
             ++ WS P   C+   C  PP   NG++    D   G R  + Y+C  G  +IG  S  C
Sbjct: 989  -NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSR--INYSCTTGHRLIGHSSAEC 1045

Query: 268  TVNNDEGEWSGPPPECRGKSLTSKVPPTV 296
             ++ +   WS  PP C  + +   +PPT+
Sbjct: 1046 ILSGNAAHWSTKPPIC--QRIPCGLPPTI 1072



 Score = 65.5 bits (158), Expect = 8e-11
 Identities = 67/269 (24%), Positives = 101/269 (37%), Gaps = 33/269 (12%)

Query: 49   LEGRTSFPED----TVITYKCEESFVKIPGEKDSVICLKG--SQWSDIEEFCNRS-CEVP 101
            L GR  FP +      + + C+E F ++ G   S   L G  S W+     C +  C  P
Sbjct: 1266 LNGRVLFPVNLQLGAKVDFVCDEGF-QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSP 1324

Query: 102  TRL-NSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLS----PKLTCLQ----NLKWS 152
              + N     +P      FP G  V Y C P   R  S        + C      N  WS
Sbjct: 1325 PVIPNGRHTGKPL---EVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 1381

Query: 153  TAVEFCKKKS-CPNPGEIRNGQIDVP---GGILFGATISFSCNTGYKLFGSTSSFCLISG 208
            +    C     C  P      ++           G ++ + C   Y  +G   S   +  
Sbjct: 1382 SPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY--YGRPFSITCLD- 1438

Query: 209  SSVQWSDPLPECREIYCPAPPQIDNGIIQGERD-HYGYRQSVTYACNKGFTMIGEHSIYC 267
             ++ WS P   C+   C  PP   NG++    D   G R  + Y+C  G  +IG  S  C
Sbjct: 1439 -NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSR--INYSCTTGHRLIGHSSAEC 1495

Query: 268  TVNNDEGEWSGPPPECRGKSLTSKVPPTV 296
             ++ +   WS  PP C  + +   +PPT+
Sbjct: 1496 ILSGNTAHWSTKPPIC--QRIPCGLPPTI 1522



 Score = 62.4 bits (150), Expect = 7e-10
 Identities = 64/247 (25%), Positives = 100/247 (40%), Gaps = 32/247 (12%)

Query: 61   ITYKCEESFVKIPGEKDSVICLKGSQ--WSDIEEFCNRSC--EVPTRLNSASLKQPYITQ 116
            +++ C+E F ++ G   S   L G +  W+     C +      P  LN      P+   
Sbjct: 2185 VSFVCDEGF-RLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPF--- 2240

Query: 117  NYFPVGTVVEYECRPGYRREPSLS----PKLTCLQ----NLKWSTAVEFCKKK---SCPN 165
               P G  + Y C     R  + +      + C      N  WS+    C+     +CP+
Sbjct: 2241 GDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPH 2300

Query: 166  PGEIRNGQIDVPGGI---LFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECRE 222
            P +I+NG   + G +   L G TIS+ C+ GY L G    FC   G    WS     C+E
Sbjct: 2301 PPKIQNGHY-IGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGI---WSQLDHYCKE 2356

Query: 223  IYCPAPPQIDNGIIQ--GERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPP 280
            + C + P   NGI +    +  Y Y   VT  C  G+T+ G     C  ++    W  P 
Sbjct: 2357 VNC-SFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADD---RWDPPL 2412

Query: 281  PECRGKS 287
             +C  ++
Sbjct: 2413 AKCTSRT 2419



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 74/279 (26%), Positives = 113/279 (40%), Gaps = 32/279 (11%)

Query: 29   LPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWS 88
            LP+    C  PP++ + +     + +F     + Y CE  +  + G   S+ C     WS
Sbjct: 1640 LPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGY-DLRGAA-SLHCTPQGDWS 1697

Query: 89   DIEEFCN-RSC-EVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYR-REPSLSPKLTC 145
                 C  +SC +   +L    +  P   Q    +G  V + C  G+R +  S+S  +  
Sbjct: 1698 PEAPRCAVKSCDDFLGQLPHGRVLFPLNLQ----LGAKVSFVCDEGFRLKGSSVSHCVLV 1753

Query: 146  LQNLKWSTAVEFCKKKSCPNPGEIRNGQ-IDVPGG-ILFGATISFSCN------TGYKLF 197
                 W+ +V  C+   CPNP  I NG+    P G I +G  IS++C+        + L 
Sbjct: 1754 GMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLI 1813

Query: 198  GSTSSFCLIS--GSSVQWSDPLPEC----REIYCPAPPQID--NGIIQGERDHYGYRQSV 249
            G ++  C     G+ V WS P P C    R  +C  P Q    +  I      +    S+
Sbjct: 1814 GESTIRCTSDPHGNGV-WSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSL 1872

Query: 250  TYACNKGFTMIGE-HSIYCTVNNDEGEWSGPPPECRGKS 287
             Y C  G+   G+  SI C  N     WS     CR KS
Sbjct: 1873 NYECRPGY--FGKMFSISCLENL---VWSSVEDNCRRKS 1906


>gi|86793036 complement receptor 1 isoform F precursor [Homo
           sapiens]
          Length = 2039

 Score =  168 bits (426), Expect = 7e-42
 Identities = 101/268 (37%), Positives = 139/268 (51%), Gaps = 26/268 (9%)

Query: 36  CGLPPDVPNAQPALEGRTSFPEDTVITYKCEE------SFVKIPGEKDSVICLKGSQ--- 86
           C  PP +PN +   +    FP    + Y C+       SF  I GE  ++ C    Q   
Sbjct: 421 CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLI-GES-TIRCTSDPQGNG 478

Query: 87  -WSDIEEFCN--RSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKL 143
            WS     C     C+ P     A LK      + FP+GT ++YECRP Y   P     +
Sbjct: 479 VWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASD-FPIGTSLKYECRPEYYGRPF---SI 534

Query: 144 TCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSF 203
           TCL NL WS+  + CK+KSC  P +  NG + V   I  G+ I++SC TG++L G +S+ 
Sbjct: 535 TCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAE 594

Query: 204 CLISGSSVQWSDPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG------ 256
           C++SG++  WS   P C+ I C  PP I NG  I   R+++ Y   VTY CN G      
Sbjct: 595 CILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKV 654

Query: 257 FTMIGEHSIYCTVNNDE-GEWSGPPPEC 283
           F ++GE SIYCT N+D+ G WSGP P+C
Sbjct: 655 FELVGEPSIYCTSNDDQVGIWSGPAPQC 682



 Score =  168 bits (425), Expect = 8e-42
 Identities = 101/268 (37%), Positives = 139/268 (51%), Gaps = 26/268 (9%)

Query: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEE------SFVKIPGEKDSVICLKGSQ--- 86
            C  PP +PN +   +    FP    + Y C+       SF  I GE  ++ C    Q   
Sbjct: 871  CPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLI-GES-TIRCTSDPQGNG 928

Query: 87   -WSDIEEFCN--RSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKL 143
             WS     C     C+ P     A LK      + FP+GT ++YECRP Y   P     +
Sbjct: 929  VWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASD-FPIGTSLKYECRPEYYGRPF---SI 984

Query: 144  TCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSF 203
            TCL NL WS+  + CK+KSC  P +  NG + V   I  G+ I++SC TG++L G +S+ 
Sbjct: 985  TCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAE 1044

Query: 204  CLISGSSVQWSDPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG------ 256
            C++SG++  WS   P C+ I C  PP I NG  I   R+++ Y   VTY CN G      
Sbjct: 1045 CILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKV 1104

Query: 257  FTMIGEHSIYCTVNNDE-GEWSGPPPEC 283
            F ++GE SIYCT N+D+ G WSGP P+C
Sbjct: 1105 FELVGEPSIYCTSNDDQVGIWSGPAPQC 1132



 Score =  162 bits (410), Expect = 5e-40
 Identities = 80/173 (46%), Positives = 106/173 (61%), Gaps = 11/173 (6%)

Query: 119 FPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPG 178
           FP+GT + YECRPGY   P     + CL+N  W+ A + C++KSC NP +  NG + V  
Sbjct: 63  FPIGTYLNYECRPGYSGRPF---SIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIK 119

Query: 179 GILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNG-IIQ 237
           GI FG+ I +SC  GY+L GS+S+ C+ISG +V W +  P C  I C  PP I NG  I 
Sbjct: 120 GIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFIS 179

Query: 238 GERDHYGYRQSVTYACNKG------FTMIGEHSIYCTVNNDE-GEWSGPPPEC 283
             R+++ Y   VTY CN G      F ++GE SIYCT N+D+ G WSGP P+C
Sbjct: 180 TNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC 232



 Score =  155 bits (391), Expect = 7e-38
 Identities = 95/270 (35%), Positives = 131/270 (48%), Gaps = 27/270 (10%)

Query: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEES-----FVKIPGEKDSVICLKGSQ---- 86
            C  PP + N +         P    I+Y C+          + GE  ++ C         
Sbjct: 1321 CPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGES-TIRCTSDPHGNGV 1379

Query: 87   WSDIEEFCNRS-----CEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSP 141
            WS     C  S     C+ P +   AS   P I    FPVGT + YECRPGY  +     
Sbjct: 1380 WSSPAPRCELSVRAGHCKTPEQFPFASPTIP-INDFEFPVGTSLNYECRPGYFGKMF--- 1435

Query: 142  KLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTS 201
             ++CL+NL WS+  + C++KSC  P E  NG + +     FG+T+++SCN G++L GS S
Sbjct: 1436 SISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPS 1495

Query: 202  SFCLISGSSVQWSDPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG---- 256
            + CL+SG++V W    P C  I C  PP I NG      R  +     VTY C+ G    
Sbjct: 1496 TTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGE 1555

Query: 257  --FTMIGEHSIYCTVNNDE-GEWSGPPPEC 283
              F ++GE SIYCT  +D+ G WS PPP C
Sbjct: 1556 QLFELVGERSIYCTSKDDQVGVWSSPPPRC 1585



 Score =  136 bits (342), Expect = 4e-32
 Identities = 80/254 (31%), Positives = 131/254 (51%), Gaps = 15/254 (5%)

Query: 39  PPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSC 98
           PP+V N     + R+ F  + V+ ++C+  FV + G +  V C   ++W      C+R C
Sbjct: 240 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFV-MKGPR-RVKCQALNKWEPELPSCSRVC 297

Query: 99  EVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFC 158
           + P  +  A   Q    ++ F  G  V Y C PGY    + S  + C     WS A   C
Sbjct: 298 QPPPDVLHAERTQR--DKDNFSPGQEVFYSCEPGYDLRGAAS--MRCTPQGDWSPAAPTC 353

Query: 159 KKKSCPN-PGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPL 217
           + KSC +  G++ NG++  P  +  GA + F C+ G++L GS++S+C+++G    W+  +
Sbjct: 354 EVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSV 413

Query: 218 PECREIYCPAPPQIDNGIIQGE-RDHYGYRQSVTYACN------KGFTMIGEHSIYCTVN 270
           P C +I+CP+PP I NG   G+  + + + ++V Y C+        F +IGE +I CT +
Sbjct: 414 PVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSD 473

Query: 271 -NDEGEWSGPPPEC 283
               G WS P P C
Sbjct: 474 PQGNGVWSSPAPRC 487



 Score =  136 bits (342), Expect = 4e-32
 Identities = 80/254 (31%), Positives = 131/254 (51%), Gaps = 15/254 (5%)

Query: 39  PPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSC 98
           PP+V N     + R+ F  + V+ ++C+  FV + G +  V C   ++W      C+R C
Sbjct: 690 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFV-MKGPR-RVKCQALNKWEPELPSCSRVC 747

Query: 99  EVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFC 158
           + P  +  A   Q    ++ F  G  V Y C PGY    + S  + C     WS A   C
Sbjct: 748 QPPPDVLHAERTQR--DKDNFSPGQEVFYSCEPGYDLRGAAS--MRCTPQGDWSPAAPTC 803

Query: 159 KKKSCPN-PGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPL 217
           + KSC +  G++ NG++  P  +  GA + F C+ G++L GS++S+C+++G    W+  +
Sbjct: 804 EVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSV 863

Query: 218 PECREIYCPAPPQIDNGIIQGE-RDHYGYRQSVTYACN------KGFTMIGEHSIYCTVN 270
           P C +I+CP+PP I NG   G+  + + + ++V Y C+        F +IGE +I CT +
Sbjct: 864 PVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSD 923

Query: 271 -NDEGEWSGPPPEC 283
               G WS P P C
Sbjct: 924 PQGNGVWSSPAPRC 937



 Score =  127 bits (320), Expect = 1e-29
 Identities = 78/253 (30%), Positives = 120/253 (47%), Gaps = 15/253 (5%)

Query: 40   PDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCE 99
            P+V NA      R+ F    +I ++C+  FV +     +V C    +W      C+R C+
Sbjct: 1594 PEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSH--TVQCQTNGRWGPKLPHCSRVCQ 1651

Query: 100  VPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCK 159
             P  +        +  Q+ F  G  V Y C P Y    + S  L C     WS     C 
Sbjct: 1652 PPPEILHGEHTLSH--QDNFSPGQEVFYSCEPSYDLRGAAS--LHCTPQGDWSPEAPRCT 1707

Query: 160  KKSCPN-PGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLP 218
             KSC +  G++ +G++ +P  +  GA +SF C+ G++L G ++S C+++G    W+  +P
Sbjct: 1708 VKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVP 1767

Query: 219  ECREIYCPAPPQIDNGIIQGER-DHYGYRQSVTYACN------KGFTMIGEHSIYCTVN- 270
             C +I+CP PP I NG   G       Y + ++YAC+        F +IGE SI CT + 
Sbjct: 1768 VCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDP 1827

Query: 271  NDEGEWSGPPPEC 283
               G WS P P C
Sbjct: 1828 QGNGVWSSPAPRC 1840



 Score =  125 bits (313), Expect = 8e-29
 Identities = 79/254 (31%), Positives = 123/254 (48%), Gaps = 15/254 (5%)

Query: 39   PPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSC 98
            PP+V N     + R+ F  + V+ ++C+  FV + G +  V C   ++W      C+R C
Sbjct: 1140 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFV-MKGPR-RVKCQALNKWEPELPSCSRVC 1197

Query: 99   EVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFC 158
            + P  +        +  Q+ F  G  V Y C PGY    + S  L C     WS     C
Sbjct: 1198 QPPPEILHGEHTPSH--QDNFSPGQEVFYSCEPGYDLRGAAS--LHCTPQGDWSPEAPRC 1253

Query: 159  KKKSCPN-PGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPL 217
              KSC +  G++ +G++  P  +  GA +SF C+ G++L GS+ S C++ G    W++ +
Sbjct: 1254 AVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSV 1313

Query: 218  PECREIYCPAPPQIDNGIIQG-ERDHYGYRQSVTYACN------KGFTMIGEHSIYCTVN 270
            P C  I+CP PP I NG   G       Y + ++Y C+        F +IGE +I CT +
Sbjct: 1314 PVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSD 1373

Query: 271  -NDEGEWSGPPPEC 283
             +  G WS P P C
Sbjct: 1374 PHGNGVWSSPAPRC 1387



 Score =  115 bits (288), Expect = 7e-26
 Identities = 84/291 (28%), Positives = 125/291 (42%), Gaps = 30/291 (10%)

Query: 21  LLLLVLLCLPAVWGDCGLPPDVPNAQPA-LEGRTSFPEDTVITYKCEESFVKIPGEKDSV 79
           L ++VLL LP  WG C  P  +P A+P  L     FP  T + Y+C   +    G   S+
Sbjct: 28  LAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGY---SGRPFSI 84

Query: 80  ICLKGSQWSDIEEFCNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPS 138
           ICLK S W+  ++ C R SC  P    +  +   ++ +     G+ ++Y C  GYR   S
Sbjct: 85  ICLKNSVWTGAKDRCRRKSCRNPPDPVNGMV---HVIKG-IQFGSQIKYSCTKGYRLIGS 140

Query: 139 LSPKLTCL---QNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPG--GILFGATISFSCNTG 193
            S   TC+     + W      C +  C  P  I NG           +G+ +++ CN G
Sbjct: 141 SS--ATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPG 198

Query: 194 ------YKLFGSTSSFCLISGSSVQ-WSDPLPECREIYCPAPPQIDNGI-IQGERDHYGY 245
                 ++L G  S +C  +   V  WS P P+C       PP ++NGI +   R  +  
Sbjct: 199 SGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSL 258

Query: 246 RQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTV 296
            + V + C  GF M G   + C   N   +W    P C   S   + PP V
Sbjct: 259 NEVVEFRCQPGFVMKGPRRVKCQALN---KWEPELPSC---SRVCQPPPDV 303



 Score =  114 bits (284), Expect = 2e-25
 Identities = 80/278 (28%), Positives = 115/278 (41%), Gaps = 30/278 (10%)

Query: 34   GDCGLPPDVPNAQPALE-GRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEE 92
            G C  P   P A P +      FP  T + Y+C   +    G+  S+ CL+   WS +E+
Sbjct: 1394 GHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYF---GKMFSISCLENLVWSSVED 1450

Query: 93   FCNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCL---QN 148
             C R SC  P    +  +     TQ     G+ V Y C  G+R   S  P  TCL    N
Sbjct: 1451 NCRRKSCGPPPEPFNGMVHINTDTQ----FGSTVNYSCNEGFRLIGS--PSTTCLVSGNN 1504

Query: 149  LKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILF--GATISFSCNTG------YKLFGST 200
            + W      C+  SC  P  I NG         F  G  +++ C+TG      ++L G  
Sbjct: 1505 VTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGER 1564

Query: 201  SSFCLISGSSVQ-WSDPLPECREIYCPAPPQIDNGI-IQGERDHYGYRQSVTYACNKGFT 258
            S +C      V  WS P P C        P+++N I + G R  +   + + + C  GF 
Sbjct: 1565 SIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFV 1624

Query: 259  MIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTV 296
            M+G H++ C  N   G W    P C   S   + PP +
Sbjct: 1625 MVGSHTVQCQTN---GRWGPKLPHC---SRVCQPPPEI 1656



 Score = 94.0 bits (232), Expect = 2e-19
 Identities = 78/266 (29%), Positives = 122/266 (45%), Gaps = 27/266 (10%)

Query: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCN 95
            C  PP++ + +  L  + +F     + Y CE S+  + G   S+ C     WS     C 
Sbjct: 1650 CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSY-DLRGAA-SLHCTPQGDWSPEAPRCT 1707

Query: 96   -RSC-EVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYR-REPSLSPKLTCLQNLKWS 152
             +SC +   +L    +  P   Q    +G  V + C  G+R +  S S  +       W+
Sbjct: 1708 VKSCDDFLGQLPHGRVLLPLNLQ----LGAKVSFVCDEGFRLKGRSASHCVLAGMKALWN 1763

Query: 153  TAVEFCKKKSCPNPGEIRNGQ-IDVP-GGILFGATISFSCNT------GYKLFGSTSSFC 204
            ++V  C++  CPNP  I NG+    P G I +G  IS++C+T       + L G +S  C
Sbjct: 1764 SSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRC 1823

Query: 205  LI--SGSSVQWSDPLPECR---EIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKGFT 258
                 G+ V WS P P C       CP PP+I NG  I G    Y    +++Y C+ G+ 
Sbjct: 1824 TSDPQGNGV-WSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYL 1882

Query: 259  MIGEHSIYCTVNNDEGEWSGPPPECR 284
            ++G+  I+CT   D+G WS     C+
Sbjct: 1883 LVGKGFIFCT---DQGIWSQLDHYCK 1905



 Score = 90.1 bits (222), Expect = 3e-18
 Identities = 75/278 (26%), Positives = 113/278 (40%), Gaps = 26/278 (9%)

Query: 32  VWGDCGLPPDVPNAQPALEGRTS-FPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDI 90
           + G C  P     A+   +   S FP  T + Y+C   +    G   S+ CL    WS  
Sbjct: 489 ILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY---GRPFSITCLDNLVWSSP 545

Query: 91  EEFCNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNL 149
           ++ C R SC+ P    +  +    IT     VG+ + Y C  G+R     S +     N 
Sbjct: 546 KDVCKRKSCKTPPDPVNGMVH--VITD--IQVGSRINYSCTTGHRLIGHSSAECILSGNA 601

Query: 150 K-WSTAVEFCKKKSCPNPGEIRNGQIDVPG--GILFGATISFSCNTG------YKLFGST 200
             WST    C++  C  P  I NG           +G+ +++ CN G      ++L G  
Sbjct: 602 AHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEP 661

Query: 201 SSFCLISGSSVQ-WSDPLPECREIYCPAPPQIDNGIIQGE-RDHYGYRQSVTYACNKGFT 258
           S +C  +   V  WS P P+C       PP ++NGI+  + R  +   + V + C  GF 
Sbjct: 662 SIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFV 721

Query: 259 MIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTV 296
           M G   + C   N   +W    P C   S   + PP V
Sbjct: 722 MKGPRRVKCQALN---KWEPELPSC---SRVCQPPPDV 753



 Score = 89.7 bits (221), Expect = 4e-18
 Identities = 74/278 (26%), Positives = 113/278 (40%), Gaps = 26/278 (9%)

Query: 32   VWGDCGLPPDVPNAQPALEGRTS-FPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDI 90
            + G C  P     A+   +   S FP  T + Y+C   +    G   S+ CL    WS  
Sbjct: 939  ILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY---GRPFSITCLDNLVWSSP 995

Query: 91   EEFCNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNL 149
            ++ C R SC+ P    +  +    IT     VG+ + Y C  G+R     S +     N 
Sbjct: 996  KDVCKRKSCKTPPDPVNGMVH--VITD--IQVGSRINYSCTTGHRLIGHSSAECILSGNT 1051

Query: 150  K-WSTAVEFCKKKSCPNPGEIRNGQIDVPG--GILFGATISFSCNTG------YKLFGST 200
              WST    C++  C  P  I NG           +G+ +++ CN G      ++L G  
Sbjct: 1052 AHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEP 1111

Query: 201  SSFCLISGSSVQ-WSDPLPECREIYCPAPPQIDNGIIQGE-RDHYGYRQSVTYACNKGFT 258
            S +C  +   V  WS P P+C       PP ++NGI+  + R  +   + V + C  GF 
Sbjct: 1112 SIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFV 1171

Query: 259  MIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTV 296
            M G   + C   N   +W    P C   S   + PP +
Sbjct: 1172 MKGPRRVKCQALN---KWEPELPSC---SRVCQPPPEI 1203



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 74/267 (27%), Positives = 109/267 (40%), Gaps = 28/267 (10%)

Query: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQ--WSDIEEF 93
            CG PP+  N    +   T F   + + Y C E F ++ G   +   + G+   W      
Sbjct: 1457 CGPPPEPFNGMVHINTDTQF--GSTVNYSCNEGF-RLIGSPSTTCLVSGNNVTWDKKAPI 1513

Query: 94   CNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLS----PKLTCL-- 146
            C   SCE P  +++        T   F  GTVV Y+C  G   E          + C   
Sbjct: 1514 CEIISCEPPPTISNGDFYSNNRTS--FHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSK 1571

Query: 147  --QNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGAT---ISFSCNTGYKLFGSTS 201
              Q   WS+    C   +     E+ N  I VPG   F      I F C  G+ + GS +
Sbjct: 1572 DDQVGVWSSPPPRCISTNKCTAPEVENA-IRVPGNRSFFTLTEIIRFRCQPGFVMVGSHT 1630

Query: 202  SFCLISGSSVQWSDPLPECREIYCPAPPQIDNGI-IQGERDHYGYRQSVTYACNKGFTMI 260
              C  +G   +W   LP C  + C  PP+I +G      +D++   Q V Y+C   + + 
Sbjct: 1631 VQCQTNG---RWGPKLPHCSRV-CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLR 1686

Query: 261  GEHSIYCTVNNDEGEWSGPPPECRGKS 287
            G  S++CT    +G+WS   P C  KS
Sbjct: 1687 GAASLHCT---PQGDWSPEAPRCTVKS 1710



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 78/288 (27%), Positives = 123/288 (42%), Gaps = 41/288 (14%)

Query: 29  LPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWS 88
           LP+    C  PPDV +A+     + +F     + Y CE  +  + G   S+ C     WS
Sbjct: 290 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY-DLRGAA-SMRCTPQGDWS 347

Query: 89  DIEEFCN-RSCE--VPTRLNSASLKQPYITQNYFPV----GTVVEYECRPGYRREPSLSP 141
                C  +SC+  +   LN   L         FPV    G  V++ C  G++ + S + 
Sbjct: 348 PAAPTCEVKSCDDFMGQLLNGRVL---------FPVNLQLGAKVDFVCDEGFQLKGSSAS 398

Query: 142 --KLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQ-IDVPGGIL-FGATISFSCN------ 191
              L  +++L W+++V  C++  CP+P  I NG+    P  +  FG T++++C+      
Sbjct: 399 YCVLAGMESL-WNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRG 457

Query: 192 TGYKLFGSTSSFCLI--SGSSVQWSDPLPECREI-YCPAPPQIDNGII--QGERDHYGYR 246
           T + L G ++  C     G+ V WS P P C  + +C AP       +  Q     +   
Sbjct: 458 TSFDLIGESTIRCTSDPQGNGV-WSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIG 516

Query: 247 QSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPP 294
            S+ Y C   +      SI C    D   WS P   C+ KS   K PP
Sbjct: 517 TSLKYECRPEY-YGRPFSITCL---DNLVWSSPKDVCKRKS--CKTPP 558



 Score = 65.9 bits (159), Expect = 6e-11
 Identities = 77/288 (26%), Positives = 122/288 (42%), Gaps = 41/288 (14%)

Query: 29   LPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWS 88
            LP+    C  PPDV +A+     + +F     + Y CE  +  + G   S+ C     WS
Sbjct: 740  LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY-DLRGAA-SMRCTPQGDWS 797

Query: 89   DIEEFCN-RSCE--VPTRLNSASLKQPYITQNYFPV----GTVVEYECRPGYRREPSLSP 141
                 C  +SC+  +   LN   L         FPV    G  V++ C  G++ + S + 
Sbjct: 798  PAAPTCEVKSCDDFMGQLLNGRVL---------FPVNLQLGAKVDFVCDEGFQLKGSSAS 848

Query: 142  --KLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQ-IDVPGGIL-FGATISFSCN------ 191
               L  +++L W+++V  C++  CP+P  I NG+    P  +  FG  ++++C+      
Sbjct: 849  YCVLAGMESL-WNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRG 907

Query: 192  TGYKLFGSTSSFCLI--SGSSVQWSDPLPECREI-YCPAPPQIDNGII--QGERDHYGYR 246
            T + L G ++  C     G+ V WS P P C  + +C AP       +  Q     +   
Sbjct: 908  TSFDLIGESTIRCTSDPQGNGV-WSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIG 966

Query: 247  QSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPP 294
             S+ Y C   +      SI C    D   WS P   C+ KS   K PP
Sbjct: 967  TSLKYECRPEY-YGRPFSITCL---DNLVWSSPKDVCKRKS--CKTPP 1008



 Score = 65.5 bits (158), Expect = 8e-11
 Identities = 67/269 (24%), Positives = 101/269 (37%), Gaps = 33/269 (12%)

Query: 49  LEGRTSFPED----TVITYKCEESFVKIPGEKDSVICLKG--SQWSDIEEFCNRS-CEVP 101
           L GR  FP +      + + C+E F ++ G   S   L G  S W+     C +  C  P
Sbjct: 366 LNGRVLFPVNLQLGAKVDFVCDEGF-QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSP 424

Query: 102 TRL-NSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLS----PKLTCLQ----NLKWS 152
             + N     +P      FP G  V Y C P   R  S        + C      N  WS
Sbjct: 425 PVIPNGRHTGKPL---EVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 481

Query: 153 TAVEFCKKKS-CPNPGEIRNGQIDVP---GGILFGATISFSCNTGYKLFGSTSSFCLISG 208
           +    C     C  P      ++           G ++ + C   Y  +G   S   +  
Sbjct: 482 SPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY--YGRPFSITCLD- 538

Query: 209 SSVQWSDPLPECREIYCPAPPQIDNGIIQGERD-HYGYRQSVTYACNKGFTMIGEHSIYC 267
            ++ WS P   C+   C  PP   NG++    D   G R  + Y+C  G  +IG  S  C
Sbjct: 539 -NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSR--INYSCTTGHRLIGHSSAEC 595

Query: 268 TVNNDEGEWSGPPPECRGKSLTSKVPPTV 296
            ++ +   WS  PP C  + +   +PPT+
Sbjct: 596 ILSGNAAHWSTKPPIC--QRIPCGLPPTI 622



 Score = 65.5 bits (158), Expect = 8e-11
 Identities = 67/269 (24%), Positives = 101/269 (37%), Gaps = 33/269 (12%)

Query: 49   LEGRTSFPED----TVITYKCEESFVKIPGEKDSVICLKG--SQWSDIEEFCNRS-CEVP 101
            L GR  FP +      + + C+E F ++ G   S   L G  S W+     C +  C  P
Sbjct: 816  LNGRVLFPVNLQLGAKVDFVCDEGF-QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSP 874

Query: 102  TRL-NSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLS----PKLTCLQ----NLKWS 152
              + N     +P      FP G  V Y C P   R  S        + C      N  WS
Sbjct: 875  PVIPNGRHTGKPL---EVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 931

Query: 153  TAVEFCKKKS-CPNPGEIRNGQIDVP---GGILFGATISFSCNTGYKLFGSTSSFCLISG 208
            +    C     C  P      ++           G ++ + C   Y  +G   S   +  
Sbjct: 932  SPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY--YGRPFSITCLD- 988

Query: 209  SSVQWSDPLPECREIYCPAPPQIDNGIIQGERD-HYGYRQSVTYACNKGFTMIGEHSIYC 267
             ++ WS P   C+   C  PP   NG++    D   G R  + Y+C  G  +IG  S  C
Sbjct: 989  -NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSR--INYSCTTGHRLIGHSSAEC 1045

Query: 268  TVNNDEGEWSGPPPECRGKSLTSKVPPTV 296
             ++ +   WS  PP C  + +   +PPT+
Sbjct: 1046 ILSGNTAHWSTKPPIC--QRIPCGLPPTI 1072



 Score = 62.4 bits (150), Expect = 7e-10
 Identities = 64/247 (25%), Positives = 100/247 (40%), Gaps = 32/247 (12%)

Query: 61   ITYKCEESFVKIPGEKDSVICLKGSQ--WSDIEEFCNRSC--EVPTRLNSASLKQPYITQ 116
            +++ C+E F ++ G   S   L G +  W+     C +      P  LN      P+   
Sbjct: 1735 VSFVCDEGF-RLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPF--- 1790

Query: 117  NYFPVGTVVEYECRPGYRREPSLS----PKLTCLQ----NLKWSTAVEFCKKK---SCPN 165
               P G  + Y C     R  + +      + C      N  WS+    C+     +CP+
Sbjct: 1791 GDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPH 1850

Query: 166  PGEIRNGQIDVPGGI---LFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECRE 222
            P +I+NG   + G +   L G TIS+ C+ GY L G    FC   G    WS     C+E
Sbjct: 1851 PPKIQNGHY-IGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGI---WSQLDHYCKE 1906

Query: 223  IYCPAPPQIDNGIIQ--GERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPP 280
            + C + P   NGI +    +  Y Y   VT  C  G+T+ G     C  ++    W  P 
Sbjct: 1907 VNC-SFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADD---RWDPPL 1962

Query: 281  PECRGKS 287
             +C  ++
Sbjct: 1963 AKCTSRT 1969



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 74/279 (26%), Positives = 113/279 (40%), Gaps = 32/279 (11%)

Query: 29   LPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWS 88
            LP+    C  PP++ + +     + +F     + Y CE  +  + G   S+ C     WS
Sbjct: 1190 LPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGY-DLRGAA-SLHCTPQGDWS 1247

Query: 89   DIEEFCN-RSC-EVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYR-REPSLSPKLTC 145
                 C  +SC +   +L    +  P   Q    +G  V + C  G+R +  S+S  +  
Sbjct: 1248 PEAPRCAVKSCDDFLGQLPHGRVLFPLNLQ----LGAKVSFVCDEGFRLKGSSVSHCVLV 1303

Query: 146  LQNLKWSTAVEFCKKKSCPNPGEIRNGQ-IDVPGG-ILFGATISFSCN------TGYKLF 197
                 W+ +V  C+   CPNP  I NG+    P G I +G  IS++C+        + L 
Sbjct: 1304 GMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLI 1363

Query: 198  GSTSSFCLIS--GSSVQWSDPLPEC----REIYCPAPPQID--NGIIQGERDHYGYRQSV 249
            G ++  C     G+ V WS P P C    R  +C  P Q    +  I      +    S+
Sbjct: 1364 GESTIRCTSDPHGNGV-WSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSL 1422

Query: 250  TYACNKGFTMIGE-HSIYCTVNNDEGEWSGPPPECRGKS 287
             Y C  G+   G+  SI C  N     WS     CR KS
Sbjct: 1423 NYECRPGY--FGKMFSISCLENL---VWSSVEDNCRRKS 1456


>gi|148922949 complement component (3b/4b) receptor 1-like [Homo
           sapiens]
          Length = 569

 Score =  155 bits (392), Expect = 6e-38
 Identities = 89/222 (40%), Positives = 123/222 (55%), Gaps = 21/222 (9%)

Query: 71  KIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNY-FPVGTVVEYEC 129
           + PG   + + L  S +SD        C VP  L  A  +   +T ++ FP+GT + YEC
Sbjct: 15  RFPGLLLAALVLLLSSFSD-------QCNVPEWLPFA--RPTNLTDDFEFPIGTYLNYEC 65

Query: 130 RPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFS 189
           RPGY   P     + CL+N  W++A + CK+KSC NP +  NG   V   I F + I +S
Sbjct: 66  RPGYSGRPF---SIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYS 122

Query: 190 CNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQG-ERDHYGYRQS 248
           C  GY+L GS+S+ C+ISG++V W +  P C  I C  PP I NG      R+++ Y   
Sbjct: 123 CPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSV 182

Query: 249 VTYACNKG------FTMIGEHSIYCTVNNDE-GEWSGPPPEC 283
           VTY CN G      F ++GE SIYCT  +D+ G WSGP P+C
Sbjct: 183 VTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQC 224



 Score =  127 bits (318), Expect = 2e-29
 Identities = 90/320 (28%), Positives = 140/320 (43%), Gaps = 34/320 (10%)

Query: 39  PPDVPNAQPALEGRTSFPEDTVITYKCEESF-VKIPGEKDSVICLKGSQWSDIEEFCNRS 97
           PP+V N     + R+ F  + V+ ++C+  F +K P     V C   ++W      C+R 
Sbjct: 232 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSH---VKCQALNKWEPELPSCSRV 288

Query: 98  CEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEF 157
           C+ P  +  A   Q    ++ F  G  V Y C PGY    S    L C     WS A   
Sbjct: 289 CQPPPDVLHAERTQR--DKDNFSPGQEVFYSCEPGYDLRGSTY--LHCTPQGDWSPAAPR 344

Query: 158 CKKKSCPN-PGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDP 216
           C+ KSC +  G++ NG +  P  +  GA + F C+ G++L GS++S+C+++G    W+  
Sbjct: 345 CEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSS 404

Query: 217 LPECREIYCPAPPQIDNGIIQGERD-HYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGE 275
           +P C    C  PP   NG++    D H G R  + Y+C  G  +IG  S  C ++ +   
Sbjct: 405 VPVCERKSCETPPVPVNGMVHVITDIHVGSR--INYSCTTGHRLIGHSSAECILSGNTAH 462

Query: 276 WSGPPPECRGKSLTSKVPPTVQKPTTVNVPT------TEVSPT--------------SQK 315
           WS  PP C  + +    PP +        P        EVS T               + 
Sbjct: 463 WSMKPPIC--QQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGES 520

Query: 316 TTTKTTTPNAQATRSTPVSR 335
           T  +T+ P+     S+P  R
Sbjct: 521 TIRRTSEPHGNGVWSSPAPR 540



 Score =  114 bits (286), Expect = 1e-25
 Identities = 81/267 (30%), Positives = 131/267 (49%), Gaps = 19/267 (7%)

Query: 29  LPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWS 88
           LP+    C  PPDV +A+     + +F     + Y CE  +  + G    + C     WS
Sbjct: 282 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY-DLRGST-YLHCTPQGDWS 339

Query: 89  DIEEFCN-RSCE-VPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPK--LT 144
                C  +SC+    +L +  +  P   Q    +G  V++ C  G++ + S +    L 
Sbjct: 340 PAAPRCEVKSCDDFLGQLPNGHVLFPLNLQ----LGAKVDFVCDEGFQLKGSSASYCVLA 395

Query: 145 CLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFC 204
            +++L W+++V  C++KSC  P    NG + V   I  G+ I++SC TG++L G +S+ C
Sbjct: 396 GMESL-WNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAEC 454

Query: 205 LISGSSVQWSDPLPECREIYCPAPPQIDNGIIQG-ERDHYGYRQSVTYACN------KGF 257
           ++SG++  WS   P C++I+CP PP I NG   G       Y + V+Y C+        F
Sbjct: 455 ILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTF 514

Query: 258 TMIGEHSIYCTVN-NDEGEWSGPPPEC 283
            +IGE +I  T   +  G WS P P C
Sbjct: 515 NLIGESTIRRTSEPHGNGVWSSPAPRC 541



 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 64/265 (24%), Positives = 103/265 (38%), Gaps = 24/265 (9%)

Query: 36  CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQ--WSDIEEF 93
           C  PPD  N    +     F     I Y C + + ++ G   +   + G+   W +    
Sbjct: 96  CRNPPDPVNGMAHVIKDIQFRSQ--IKYSCPKGY-RLIGSSSATCIISGNTVIWDNKTPV 152

Query: 94  CNRS-CEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLS----PKLTCLQN 148
           C+R  C +P  + +       I++ YF  G+VV Y C  G R +        P + C   
Sbjct: 153 CDRIICGLPPTIANGDFTS--ISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSK 210

Query: 149 LK----WSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGAT--ISFSCNTGYKLFGSTSS 202
                 WS     C   +   P  + NG +      LF     + F C  G+ + G +  
Sbjct: 211 DDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHV 270

Query: 203 FCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGE 262
            C       +W   LP C  +  P P  +     Q ++D++   Q V Y+C  G+ + G 
Sbjct: 271 KCQALN---KWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGS 327

Query: 263 HSIYCTVNNDEGEWSGPPPECRGKS 287
             ++CT    +G+WS   P C  KS
Sbjct: 328 TYLHCT---PQGDWSPAAPRCEVKS 349


>gi|4502503 complement component 4 binding protein, alpha chain
           precursor [Homo sapiens]
          Length = 597

 Score =  154 bits (390), Expect = 1e-37
 Identities = 80/198 (40%), Positives = 113/198 (57%), Gaps = 5/198 (2%)

Query: 97  SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVE 156
           +C  P  L+ A+     +T+  F  GT ++Y C PGY R  S +  LTC  + +W     
Sbjct: 49  NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHS-TQTLTCNSDGEWVYNT- 106

Query: 157 FCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDP 216
           FC  K C +PGE+RNGQ+++   + FG+ I FSC+ G+ L GST+S C +    V WS P
Sbjct: 107 FCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHP 166

Query: 217 LPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDE-GE 275
           LP+C  + C  PP I NG   GE + Y Y  SVTY+C+  F+++G  SI CTV N+  G 
Sbjct: 167 LPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGV 226

Query: 276 WSGPPPECRGKSLTSKVP 293
           W   PP C  + +T + P
Sbjct: 227 WRPSPPTC--EKITCRKP 242



 Score =  103 bits (256), Expect = 3e-22
 Identities = 70/239 (29%), Positives = 115/239 (48%), Gaps = 28/239 (11%)

Query: 57  EDTVITYKCEESFVKIPGEKDSVI-CLKGSQWSDIEEFC--NRSCEVPTRLNSASLKQPY 113
           +DT++ +KC++ FV       SVI C   S+W+     C  N    +P   +++    P 
Sbjct: 260 KDTIV-FKCQKGFVL---RGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPR 315

Query: 114 IT-QNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNP----GE 168
            T ++ + VGTV+ Y C PGY+        + C +NL+W T  + C+   CP P    GE
Sbjct: 316 PTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRW-TPYQGCEALCCPEPKLNNGE 374

Query: 169 IRNGQIDVPGG---ILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYC 225
           I   +   P       +G  ISFSC+        TS F  I      WS   P C +I C
Sbjct: 375 ITQHRKSRPANHCVYFYGDEISFSCH-------ETSRFSAICQGDGTWSPRTPSCGDI-C 426

Query: 226 PAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECR 284
             PP+I +G  +    +  +++ + Y C+KG+ ++G+  + C+ ++    WS P P+C+
Sbjct: 427 NFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSH----WSAPAPQCK 481



 Score =  101 bits (252), Expect = 1e-21
 Identities = 67/272 (24%), Positives = 118/272 (43%), Gaps = 15/272 (5%)

Query: 22  LLLVLLCLPAVWGDCGLPPDVPNAQPA--LEGRTSFPEDTVITYKCEESFVKIPGEKDSV 79
           + L+   LPAV G+CG PP +  A P       T F   T + Y C   +V+    + ++
Sbjct: 36  MTLIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQ-TL 94

Query: 80  ICLKGSQWSDIEEFC-NRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPS 138
            C    +W     FC  + C  P  L +  ++     +     G+ +E+ C  G+    S
Sbjct: 95  TCNSDGEWV-YNTFCIYKRCRHPGELRNGQVE----IKTDLSFGSQIEFSCSEGFFLIGS 149

Query: 139 LSPKLTCL-QNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGIL-FGATISFSCNTGYKL 196
            + +     + + WS  +  C+   C  P +IRNG+         +G ++++SC+  + L
Sbjct: 150 TTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSL 209

Query: 197 FGSTSSFCLISGSSVQ-WSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNK 255
            G  S  C +   ++  W    P C +I C  P      ++ G    Y Y+ ++ + C K
Sbjct: 210 LGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQK 269

Query: 256 GFTMIGEHSIYCTVNNDEGEWSGPPPECRGKS 287
           GF + G   I+C   + + +W+  PP C   S
Sbjct: 270 GFVLRGSSVIHC---DADSKWNPSPPACEPNS 298



 Score = 79.3 bits (194), Expect = 5e-15
 Identities = 65/254 (25%), Positives = 101/254 (39%), Gaps = 28/254 (11%)

Query: 40  PDVPNAQ----PALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCN 95
           PD+P+A     P       +   TV+ Y+C   +     E  +VIC K  +W+  +  C 
Sbjct: 303 PDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQG-CE 361

Query: 96  RSCEVPTRLNSASLKQ-----PYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLK 150
             C    +LN+  + Q     P     YF  G  + + C    R          C  +  
Sbjct: 362 ALCCPEPKLNNGEITQHRKSRPANHCVYF-YGDEISFSCHETSRFSA------ICQGDGT 414

Query: 151 WSTAVEFCKKKSCPNPGEIRNGQIDVPGGI-LFGATISFSCNTGYKLFGSTSSFCLISGS 209
           WS     C    C  P +I +G          F   I + C+ GY L G     C  S  
Sbjct: 415 WSPRTPSCGD-ICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYS-- 471

Query: 210 SVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTV 269
              WS P P+C+ +     P++ NG +  ++D Y   ++VT  C+ G+ ++G  SI C+ 
Sbjct: 472 --HWSAPAPQCKALC--RKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSG 527

Query: 270 NNDEGEWSGPPPEC 283
           N     W    P+C
Sbjct: 528 NR---TWYPEVPKC 538



 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 48/186 (25%), Positives = 72/186 (38%), Gaps = 12/186 (6%)

Query: 36  CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCN 95
           C   P + N +     ++      V  Y  E SF      + S IC     WS     C 
Sbjct: 364 CCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAICQGDGTWSPRTPSCG 423

Query: 96  RSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAV 155
             C  P ++     KQ   + +Y      + YEC  GY        KL+C  +  WS   
Sbjct: 424 DICNFPPKIAHGHYKQ---SSSYSFFKEEIIYECDKGYILVG--QAKLSCSYS-HWSAPA 477

Query: 156 EFCKKKSCPNPGEIRNGQIDV-PGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWS 214
             C K  C  P E+ NG++ V     +    ++  C++GY + G  S  C  SG+   W 
Sbjct: 478 PQC-KALCRKP-ELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITC--SGNRT-WY 532

Query: 215 DPLPEC 220
             +P+C
Sbjct: 533 PEVPKC 538


>gi|42544177 complement component (3d/Epstein Barr virus) receptor 2
           isoform 2 [Homo sapiens]
          Length = 1033

 Score =  119 bits (297), Expect = 6e-27
 Identities = 82/263 (31%), Positives = 123/263 (46%), Gaps = 33/263 (12%)

Query: 40  PDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCE 99
           P VP     + G T +     +T+ C+ +F  + G K SV C   + W            
Sbjct: 94  PIVPGGYK-IRGSTPYRHGDSVTFACKTNF-SMNGNK-SVWCQANNMWGPTR-------- 142

Query: 100 VPTRLNSASLKQP---------YITQNYFPV--GTVVEYECRPGYRREPSLSPKLTCLQN 148
           +PT ++   L+ P         + ++N   +  G  V Y C  GY         + CL +
Sbjct: 143 LPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKI--INCLSS 200

Query: 149 LKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISG 208
            KWS     C++  C + G   NG++  P  +  G T +F C+ GY+L G  SS C+I+G
Sbjct: 201 GKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAG 260

Query: 209 SSVQWSDPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNK------GFTMIG 261
             V W+  +P C EI+CP+PP I NG  I     +  Y   VTY C+        F +IG
Sbjct: 261 QGVAWT-KMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIG 319

Query: 262 EHSIYCTVNNDE-GEWSGPPPEC 283
           E ++ CTV++ + G WSGP P C
Sbjct: 320 ESTLRCTVDSQKTGTWSGPAPRC 342



 Score =  107 bits (268), Expect = 1e-23
 Identities = 73/277 (26%), Positives = 123/277 (44%), Gaps = 28/277 (10%)

Query: 35  DCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFC 94
           +C   P + N     E   S      +TY CE  ++ + GEK  + CL   +WS +   C
Sbjct: 153 ECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLV-GEK-IINCLSSGKWSAVPPTC 210

Query: 95  NRS-CEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRRE-PSLSPKLTCLQNLKWS 152
             + C+   R  +  +K+P I +    VG    + C  GYR + P  S  +   Q + W 
Sbjct: 211 EEARCKSLGRFPNGKVKEPPILR----VGVTANFFCDEGYRLQGPPSSRCVIAGQGVAW- 265

Query: 153 TAVEFCKKKSCPNPGEIRNGQI--DVPGGILFGATISFSCN------TGYKLFGSTSSFC 204
           T +  C++  CP+P  I NG+   +    + +G+ ++++C+        + L G ++  C
Sbjct: 266 TKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRC 325

Query: 205 LISGSSV-QWSDPLPECR----EIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTM 259
            +       WS P P C      + CP P  +   ++ G++D Y Y  +V +AC  GFT+
Sbjct: 326 TVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTL 385

Query: 260 IGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTV 296
            G   I C   N +G W    P C  +    + PP +
Sbjct: 386 KGSKQIRC---NAQGTWEPSAPVCEKE---CQAPPNI 416



 Score = 92.8 bits (229), Expect = 5e-19
 Identities = 79/269 (29%), Positives = 118/269 (43%), Gaps = 30/269 (11%)

Query: 36  CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQ----WSDIE 91
           C  PP + N +       +F     ++Y+C++ F  + GEK  + C   S+    WS   
Sbjct: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLL-GEK-KLQCRSDSKGHGSWSGPS 776

Query: 92  EFCNRSCEVPTRLNSASLKQPYI---TQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQN 148
             C RS  V TR  +  +K  Y    T + +    +V  +C PG+    S    + C  +
Sbjct: 777 PQCLRSPPV-TRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRV--IRCHTD 833

Query: 149 LKWSTAVEFCKKKS---CPNPGEIRNGQIDVPGGILF----GATISFSCNTGYKLFGSTS 201
             W   V  C KK+   CP P +  NG  +  GG +     G +I +SC+ GY L G   
Sbjct: 834 NTWVPGVPTCIKKAFIGCPPPPKTPNG--NHTGGNIARFSPGMSILYSCDQGYLLVGEAL 891

Query: 202 SFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQG--ERDHYGYRQSVTYACNKGFTM 259
             C   G+   WS P P C+E+ C +P  +D GI +G   R  Y Y   VT  C  G+ +
Sbjct: 892 LLCTHEGT---WSQPAPHCKEVNCSSPADMD-GIQKGLEPRKMYQYGAVVTLECEDGYML 947

Query: 260 IGEHSIYCTVNNDEGEWSGPPPECRGKSL 288
            G     C     + +W+ P   CR +SL
Sbjct: 948 EGSPQSQC---QSDHQWNPPLAVCRSRSL 973



 Score = 92.0 bits (227), Expect = 8e-19
 Identities = 71/272 (26%), Positives = 117/272 (43%), Gaps = 23/272 (8%)

Query: 36  CGLPPDVPNAQPALEGRTSFPEDTVITYKCE---ESFVKIPGEKDSVI-CLKGSQ----W 87
           C  PP + N          FP  T +TY C    E  V+     +S I C    Q    W
Sbjct: 527 CPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTW 586

Query: 88  SDIEEFCNRSCEVPTRLNSASLKQPYITQN----YFPVGTVVEYECRPGYRREPSLSPKL 143
           S     C  S  +  + +   +   Y        YF   TV  ++C  G+  + S   ++
Sbjct: 587 SGPAPLCKLSL-LAVQCSHVHIANGYKISGKEAPYFYNDTVT-FKCYSGFTLKGS--SQI 642

Query: 144 TCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSF 203
            C  +  W   +  C+K++C +   +R    ++P G      ++ SC  GY+L G     
Sbjct: 643 RCKADNTWDPEIPVCEKETCQH---VRQSLQELPAGSRV-ELVNTSCQDGYQLTGHAYQM 698

Query: 204 CLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQG-ERDHYGYRQSVTYACNKGFTMIGE 262
           C  + + + W   +P C+ I+C  PP I NG   G   +++ Y   V+Y C++GF ++GE
Sbjct: 699 CQDAENGI-WFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGE 757

Query: 263 HSIYC-TVNNDEGEWSGPPPECRGKSLTSKVP 293
             + C + +   G WSGP P+C      ++ P
Sbjct: 758 KKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCP 789



 Score = 85.9 bits (211), Expect = 6e-17
 Identities = 72/273 (26%), Positives = 109/273 (39%), Gaps = 38/273 (13%)

Query: 30  PAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSD 89
           P    +C  PP++ N Q        F   T I Y C   +V + GE +S+ C     W+ 
Sbjct: 404 PVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLV-GE-ESIQCTSEGVWTP 461

Query: 90  IEEFCN-RSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQN 148
               C   +CE   R      +  ++  +       V   C  GY+   S+  +  C   
Sbjct: 462 PVPQCKVAACEATGRQLLTKPQHQFVRPD-------VNSSCGEGYKLSGSVYQE--CQGT 512

Query: 149 LKWSTAVEFCKKKSCPNPGEIRNGQI------DVPGGILFGATISFSCNTG------YKL 196
           + W   +  CK+ +CP P  I NG        D P    +G T++++CN G      + L
Sbjct: 513 IPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFP----YGTTVTYTCNPGPERGVEFSL 568

Query: 197 FGSTSSFCLISGSSV-QWSDPLPECR----EIYCPAPPQIDNGI-IQGERDHYGYRQSVT 250
            G ++  C  +      WS P P C+     + C +   I NG  I G+   Y Y  +VT
Sbjct: 569 IGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQC-SHVHIANGYKISGKEAPYFYNDTVT 627

Query: 251 YACNKGFTMIGEHSIYCTVNNDEGEWSGPPPEC 283
           + C  GFT+ G   I C  +N    W    P C
Sbjct: 628 FKCYSGFTLKGSSQIRCKADN---TWDPEIPVC 657



 Score = 79.0 bits (193), Expect = 7e-15
 Identities = 71/244 (29%), Positives = 104/244 (42%), Gaps = 42/244 (17%)

Query: 65  CEESF-VKIPGEKDSVICLKGSQWSDI----EEFCNRSCEVPTRLNSASLKQPYITQNYF 119
           C+E + ++ P     VI  +G  W+ +    E FC      P  LN   +       +Y 
Sbjct: 242 CDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSP---PPILNGRHIGNSLANVSY- 297

Query: 120 PVGTVVEYECRPGYRR--------EPSLSPKLTCLQNLKWSTAVEFCKKKS----CPNP- 166
             G++V Y C P            E +L   +   +   WS     C+  +    CP+P 
Sbjct: 298 --GSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQ 355

Query: 167 ---GEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREI 223
              G + +GQ D      +  T+ F+C  G+ L GS    C   G+   W    P C E 
Sbjct: 356 ILRGRMVSGQKD---RYTYNDTVIFACMFGFTLKGSKQIRCNAQGT---WEPSAPVC-EK 408

Query: 224 YCPAPPQIDNGIIQGERDH---YGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPP 280
            C APP I NG  Q E  H   +    S+ Y+CN G+ ++GE SI CT    EG W+ P 
Sbjct: 409 ECQAPPNILNG--QKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCT---SEGVWTPPV 463

Query: 281 PECR 284
           P+C+
Sbjct: 464 PQCK 467



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 63/204 (30%), Positives = 89/204 (43%), Gaps = 26/204 (12%)

Query: 121 VGTVVEYECRPGYRREPSLSPKLTCLQNLK----WSTAVEFC----KKKSCPNPGEIRNG 172
           VGTV+ Y C   +R     S  L C+   K    W      C    K  SCP P  I  G
Sbjct: 43  VGTVIRYSCSGTFRLIGEKS--LLCITKDKVDGTWDKPAPKCEYFNKYSSCPEP--IVPG 98

Query: 173 QIDVPGGILF--GATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIY---CPA 227
              + G   +  G +++F+C T + + G+ S +C    +++     LP C  ++   CPA
Sbjct: 99  GYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWC--QANNMWGPTRLPTCVSVFPLECPA 156

Query: 228 PPQIDNGIIQGER-DHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPEC--- 283
            P I NG    E         SVTY+C  G+ ++GE  I C      G+WS  PP C   
Sbjct: 157 LPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCL---SSGKWSAVPPTCEEA 213

Query: 284 RGKSLTSKVPPTVQKPTTVNVPTT 307
           R KSL       V++P  + V  T
Sbjct: 214 RCKSLGRFPNGKVKEPPILRVGVT 237



 Score = 65.5 bits (158), Expect = 8e-11
 Identities = 53/186 (28%), Positives = 78/186 (41%), Gaps = 23/186 (12%)

Query: 119 FPVGTVVEYECRPGYRREPSLSPKLTCLQNLK----WSTAVEFCKKKS----CPNPGEIR 170
           F  G  V YEC  G+        KL C  + K    WS     C +      CPNP E++
Sbjct: 738 FLYGNEVSYECDQGFYLLGE--KKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNP-EVK 794

Query: 171 NGQI--DVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECRE---IYC 225
           +G               +   CN G+ + GS    C    +   W   +P C +   I C
Sbjct: 795 HGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT---WVPGVPTCIKKAFIGC 851

Query: 226 PAPPQIDNGIIQGER-DHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECR 284
           P PP+  NG   G     +    S+ Y+C++G+ ++GE  + CT    EG WS P P C+
Sbjct: 852 PPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCT---HEGTWSQPAPHCK 908

Query: 285 GKSLTS 290
             + +S
Sbjct: 909 EVNCSS 914



 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 38/116 (32%), Positives = 53/116 (45%), Gaps = 7/116 (6%)

Query: 162 SCPNPGEIRNGQIDVPGG-ILFGATISFSCNTGYKLFGSTSSFCLISGS-SVQWSDPLPE 219
           SC +P  I NG+I      I  G  I +SC+  ++L G  S  C+        W  P P+
Sbjct: 22  SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81

Query: 220 C----REIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNN 271
           C    +   CP P       I+G    Y +  SVT+AC   F+M G  S++C  NN
Sbjct: 82  CEYFNKYSSCPEPIVPGGYKIRGSTP-YRHGDSVTFACKTNFSMNGNKSVWCQANN 136



 Score = 48.9 bits (115), Expect = 8e-06
 Identities = 32/136 (23%), Positives = 56/136 (41%), Gaps = 7/136 (5%)

Query: 28  CLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQW 87
           C+   +  C  PP  PN          F     I Y C++ ++ + GE   ++C     W
Sbjct: 843 CIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLV-GEA-LLLCTHEGTW 900

Query: 88  SDIEEFCNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCL 146
           S     C   +C  P  ++   +++    +  +  G VV  EC  GY  E   SP+  C 
Sbjct: 901 SQPAPHCKEVNCSSPADMD--GIQKGLEPRKMYQYGAVVTLECEDGYMLEG--SPQSQCQ 956

Query: 147 QNLKWSTAVEFCKKKS 162
            + +W+  +  C+ +S
Sbjct: 957 SDHQWNPPLAVCRSRS 972



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 24/75 (32%), Positives = 35/75 (46%), Gaps = 1/75 (1%)

Query: 223 IYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYC-TVNNDEGEWSGPPP 281
           I C +PP I NG I            + Y+C+  F +IGE S+ C T +  +G W  P P
Sbjct: 21  ISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAP 80

Query: 282 ECRGKSLTSKVPPTV 296
           +C   +  S  P  +
Sbjct: 81  KCEYFNKYSSCPEPI 95



 Score = 32.0 bits (71), Expect = 0.95
 Identities = 18/67 (26%), Positives = 28/67 (41%), Gaps = 2/67 (2%)

Query: 35  DCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFC 94
           +C  P D+   Q  LE R  +    V+T +CE+ ++ + G   S  C    QW+     C
Sbjct: 911 NCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYM-LEGSPQSQ-CQSDHQWNPPLAVC 968

Query: 95  NRSCEVP 101
                 P
Sbjct: 969 RSRSLAP 975


>gi|54792123 complement component (3d/Epstein Barr virus) receptor 2
           isoform 1 [Homo sapiens]
          Length = 1092

 Score =  119 bits (297), Expect = 6e-27
 Identities = 82/263 (31%), Positives = 123/263 (46%), Gaps = 33/263 (12%)

Query: 40  PDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCE 99
           P VP     + G T +     +T+ C+ +F  + G K SV C   + W            
Sbjct: 94  PIVPGGYK-IRGSTPYRHGDSVTFACKTNF-SMNGNK-SVWCQANNMWGPTR-------- 142

Query: 100 VPTRLNSASLKQP---------YITQNYFPV--GTVVEYECRPGYRREPSLSPKLTCLQN 148
           +PT ++   L+ P         + ++N   +  G  V Y C  GY         + CL +
Sbjct: 143 LPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKI--INCLSS 200

Query: 149 LKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISG 208
            KWS     C++  C + G   NG++  P  +  G T +F C+ GY+L G  SS C+I+G
Sbjct: 201 GKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAG 260

Query: 209 SSVQWSDPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNK------GFTMIG 261
             V W+  +P C EI+CP+PP I NG  I     +  Y   VTY C+        F +IG
Sbjct: 261 QGVAWT-KMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIG 319

Query: 262 EHSIYCTVNNDE-GEWSGPPPEC 283
           E ++ CTV++ + G WSGP P C
Sbjct: 320 ESTLRCTVDSQKTGTWSGPAPRC 342



 Score =  107 bits (268), Expect = 1e-23
 Identities = 73/277 (26%), Positives = 123/277 (44%), Gaps = 28/277 (10%)

Query: 35  DCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFC 94
           +C   P + N     E   S      +TY CE  ++ + GEK  + CL   +WS +   C
Sbjct: 153 ECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLV-GEK-IINCLSSGKWSAVPPTC 210

Query: 95  NRS-CEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRRE-PSLSPKLTCLQNLKWS 152
             + C+   R  +  +K+P I +    VG    + C  GYR + P  S  +   Q + W 
Sbjct: 211 EEARCKSLGRFPNGKVKEPPILR----VGVTANFFCDEGYRLQGPPSSRCVIAGQGVAW- 265

Query: 153 TAVEFCKKKSCPNPGEIRNGQI--DVPGGILFGATISFSCN------TGYKLFGSTSSFC 204
           T +  C++  CP+P  I NG+   +    + +G+ ++++C+        + L G ++  C
Sbjct: 266 TKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRC 325

Query: 205 LISGSSV-QWSDPLPECR----EIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTM 259
            +       WS P P C      + CP P  +   ++ G++D Y Y  +V +AC  GFT+
Sbjct: 326 TVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTL 385

Query: 260 IGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTV 296
            G   I C   N +G W    P C  +    + PP +
Sbjct: 386 KGSKQIRC---NAQGTWEPSAPVCEKE---CQAPPNI 416



 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 67/241 (27%), Positives = 112/241 (46%), Gaps = 15/241 (6%)

Query: 55  FPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYI 114
           F  DTV T+KC   F  + G    + C   + W      C + C+ P  L+    +    
Sbjct: 621 FYNDTV-TFKCYSGFT-LKGSSQ-IRCKADNTWDPEIPVCEKGCQSPPGLHHG--RHTGG 675

Query: 115 TQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQI 174
              +F  G  V+Y C PGY    + S  + C+ +  WS +   C++ +C +   +R    
Sbjct: 676 NTVFFVSGMTVDYTCDPGYLLVGNKS--IHCMPSGNWSPSAPRCEE-TCQH---VRQSLQ 729

Query: 175 DVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNG 234
           ++P G      ++ SC  GY+L G     C  + + + W   +P C+ I+C  PP I NG
Sbjct: 730 ELPAGSRV-ELVNTSCQDGYQLTGHAYQMCQDAENGI-WFKKIPLCKVIHCHPPPVIVNG 787

Query: 235 IIQG-ERDHYGYRQSVTYACNKGFTMIGEHSIYC-TVNNDEGEWSGPPPECRGKSLTSKV 292
              G   +++ Y   V+Y C++GF ++GE  + C + +   G WSGP P+C      ++ 
Sbjct: 788 KHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRC 847

Query: 293 P 293
           P
Sbjct: 848 P 848



 Score = 92.8 bits (229), Expect = 5e-19
 Identities = 79/269 (29%), Positives = 118/269 (43%), Gaps = 30/269 (11%)

Query: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQ----WSDIE 91
            C  PP + N +       +F     ++Y+C++ F  + GEK  + C   S+    WS   
Sbjct: 778  CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLL-GEK-KLQCRSDSKGHGSWSGPS 835

Query: 92   EFCNRSCEVPTRLNSASLKQPYI---TQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQN 148
              C RS  V TR  +  +K  Y    T + +    +V  +C PG+    S    + C  +
Sbjct: 836  PQCLRSPPV-TRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRV--IRCHTD 892

Query: 149  LKWSTAVEFCKKKS---CPNPGEIRNGQIDVPGGILF----GATISFSCNTGYKLFGSTS 201
              W   V  C KK+   CP P +  NG  +  GG +     G +I +SC+ GY L G   
Sbjct: 893  NTWVPGVPTCIKKAFIGCPPPPKTPNG--NHTGGNIARFSPGMSILYSCDQGYLLVGEAL 950

Query: 202  SFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQG--ERDHYGYRQSVTYACNKGFTM 259
              C   G+   WS P P C+E+ C +P  +D GI +G   R  Y Y   VT  C  G+ +
Sbjct: 951  LLCTHEGT---WSQPAPHCKEVNCSSPADMD-GIQKGLEPRKMYQYGAVVTLECEDGYML 1006

Query: 260  IGEHSIYCTVNNDEGEWSGPPPECRGKSL 288
             G     C     + +W+ P   CR +SL
Sbjct: 1007 EGSPQSQC---QSDHQWNPPLAVCRSRSL 1032



 Score = 85.9 bits (211), Expect = 6e-17
 Identities = 72/273 (26%), Positives = 109/273 (39%), Gaps = 38/273 (13%)

Query: 30  PAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSD 89
           P    +C  PP++ N Q        F   T I Y C   +V + GE +S+ C     W+ 
Sbjct: 404 PVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLV-GE-ESIQCTSEGVWTP 461

Query: 90  IEEFCN-RSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQN 148
               C   +CE   R      +  ++  +       V   C  GY+   S+  +  C   
Sbjct: 462 PVPQCKVAACEATGRQLLTKPQHQFVRPD-------VNSSCGEGYKLSGSVYQE--CQGT 512

Query: 149 LKWSTAVEFCKKKSCPNPGEIRNGQI------DVPGGILFGATISFSCNTG------YKL 196
           + W   +  CK+ +CP P  I NG        D P    +G T++++CN G      + L
Sbjct: 513 IPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFP----YGTTVTYTCNPGPERGVEFSL 568

Query: 197 FGSTSSFCLISGSSV-QWSDPLPECR----EIYCPAPPQIDNGI-IQGERDHYGYRQSVT 250
            G ++  C  +      WS P P C+     + C +   I NG  I G+   Y Y  +VT
Sbjct: 569 IGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQC-SHVHIANGYKISGKEAPYFYNDTVT 627

Query: 251 YACNKGFTMIGEHSIYCTVNNDEGEWSGPPPEC 283
           + C  GFT+ G   I C  +N    W    P C
Sbjct: 628 FKCYSGFTLKGSSQIRCKADN---TWDPEIPVC 657



 Score = 79.0 bits (193), Expect = 7e-15
 Identities = 71/244 (29%), Positives = 104/244 (42%), Gaps = 42/244 (17%)

Query: 65  CEESF-VKIPGEKDSVICLKGSQWSDI----EEFCNRSCEVPTRLNSASLKQPYITQNYF 119
           C+E + ++ P     VI  +G  W+ +    E FC      P  LN   +       +Y 
Sbjct: 242 CDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSP---PPILNGRHIGNSLANVSY- 297

Query: 120 PVGTVVEYECRPGYRR--------EPSLSPKLTCLQNLKWSTAVEFCKKKS----CPNP- 166
             G++V Y C P            E +L   +   +   WS     C+  +    CP+P 
Sbjct: 298 --GSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQ 355

Query: 167 ---GEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREI 223
              G + +GQ D      +  T+ F+C  G+ L GS    C   G+   W    P C E 
Sbjct: 356 ILRGRMVSGQKD---RYTYNDTVIFACMFGFTLKGSKQIRCNAQGT---WEPSAPVC-EK 408

Query: 224 YCPAPPQIDNGIIQGERDH---YGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPP 280
            C APP I NG  Q E  H   +    S+ Y+CN G+ ++GE SI CT    EG W+ P 
Sbjct: 409 ECQAPPNILNG--QKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCT---SEGVWTPPV 463

Query: 281 PECR 284
           P+C+
Sbjct: 464 PQCK 467



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 63/204 (30%), Positives = 89/204 (43%), Gaps = 26/204 (12%)

Query: 121 VGTVVEYECRPGYRREPSLSPKLTCLQNLK----WSTAVEFC----KKKSCPNPGEIRNG 172
           VGTV+ Y C   +R     S  L C+   K    W      C    K  SCP P  I  G
Sbjct: 43  VGTVIRYSCSGTFRLIGEKS--LLCITKDKVDGTWDKPAPKCEYFNKYSSCPEP--IVPG 98

Query: 173 QIDVPGGILF--GATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIY---CPA 227
              + G   +  G +++F+C T + + G+ S +C    +++     LP C  ++   CPA
Sbjct: 99  GYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWC--QANNMWGPTRLPTCVSVFPLECPA 156

Query: 228 PPQIDNGIIQGER-DHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPEC--- 283
            P I NG    E         SVTY+C  G+ ++GE  I C      G+WS  PP C   
Sbjct: 157 LPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCL---SSGKWSAVPPTCEEA 213

Query: 284 RGKSLTSKVPPTVQKPTTVNVPTT 307
           R KSL       V++P  + V  T
Sbjct: 214 RCKSLGRFPNGKVKEPPILRVGVT 237



 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 72/336 (21%), Positives = 120/336 (35%), Gaps = 90/336 (26%)

Query: 29  LPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWS 88
           +P     C  PP + + +        F     + Y C+  ++ + G K S+ C+    WS
Sbjct: 654 IPVCEKGCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLV-GNK-SIHCMPSGNWS 711

Query: 89  DIEEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEY---ECRPGYRREPSLSPKLTC 145
                C  +C+   +    SL++        P G+ VE     C+ GY+           
Sbjct: 712 PSAPRCEETCQHVRQ----SLQE-------LPAGSRVELVNTSCQDGYQLTGHAYQMCQD 760

Query: 146 LQNLKWSTAVEFCKKKSCPNPGEIRNGQID--VPGGILFGATISFSCNT----------- 192
            +N  W   +  CK   C  P  I NG+    +    L+G  +S+ C+            
Sbjct: 761 AENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQ 820

Query: 193 ----------------------------------GYKLFGSTSSFC-------------L 205
                                             GYKL  + S++              +
Sbjct: 821 CRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFI 880

Query: 206 ISGSSV-------QWSDPLPECRE---IYCPAPPQIDNGIIQGER-DHYGYRQSVTYACN 254
           ++GS V        W   +P C +   I CP PP+  NG   G     +    S+ Y+C+
Sbjct: 881 MNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCD 940

Query: 255 KGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTS 290
           +G+ ++GE  + CT    EG WS P P C+  + +S
Sbjct: 941 QGYLLVGEALLLCT---HEGTWSQPAPHCKEVNCSS 973



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 68/275 (24%), Positives = 107/275 (38%), Gaps = 31/275 (11%)

Query: 36  CGLPPDVPNAQPALEGRTSFPEDTVITYKCE---ESFVKIPGEKDSVI-CLKGSQ----W 87
           C  PP + N          FP  T +TY C    E  V+     +S I C    Q    W
Sbjct: 527 CPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTW 586

Query: 88  SDIEEFCNRSCEVPTRLNSASLKQPYITQN----YFPVGTVVEYECRPGYRREPSLSPKL 143
           S     C  S  +  + +   +   Y        YF   TV  ++C  G+  + S   ++
Sbjct: 587 SGPAPLCKLSL-LAVQCSHVHIANGYKISGKEAPYFYNDTVT-FKCYSGFTLKGS--SQI 642

Query: 144 TCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILF--GATISFSCNTGYKLFGSTS 201
            C  +  W   +  C+K  C +P  + +G+      + F  G T+ ++C+ GY L G+ S
Sbjct: 643 RCKADNTWDPEIPVCEK-GCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKS 701

Query: 202 SFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIG 261
             C+ SG+   WS   P C E  C    Q    +  G R      + V  +C  G+ + G
Sbjct: 702 IHCMPSGN---WSPSAPRCEET-CQHVRQSLQELPAGSR-----VELVNTSCQDGYQLTG 752

Query: 262 EHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTV 296
            H+     + + G W    P C  K +    PP +
Sbjct: 753 -HAYQMCQDAENGIWFKKIPLC--KVIHCHPPPVI 784



 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 38/116 (32%), Positives = 53/116 (45%), Gaps = 7/116 (6%)

Query: 162 SCPNPGEIRNGQIDVPGG-ILFGATISFSCNTGYKLFGSTSSFCLISGS-SVQWSDPLPE 219
           SC +P  I NG+I      I  G  I +SC+  ++L G  S  C+        W  P P+
Sbjct: 22  SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81

Query: 220 C----REIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNN 271
           C    +   CP P       I+G    Y +  SVT+AC   F+M G  S++C  NN
Sbjct: 82  CEYFNKYSSCPEPIVPGGYKIRGSTP-YRHGDSVTFACKTNFSMNGNKSVWCQANN 136



 Score = 48.9 bits (115), Expect = 8e-06
 Identities = 32/136 (23%), Positives = 56/136 (41%), Gaps = 7/136 (5%)

Query: 28   CLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQW 87
            C+   +  C  PP  PN          F     I Y C++ ++ + GE   ++C     W
Sbjct: 902  CIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLV-GEA-LLLCTHEGTW 959

Query: 88   SDIEEFCNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCL 146
            S     C   +C  P  ++   +++    +  +  G VV  EC  GY  E   SP+  C 
Sbjct: 960  SQPAPHCKEVNCSSPADMD--GIQKGLEPRKMYQYGAVVTLECEDGYMLEG--SPQSQCQ 1015

Query: 147  QNLKWSTAVEFCKKKS 162
             + +W+  +  C+ +S
Sbjct: 1016 SDHQWNPPLAVCRSRS 1031



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 24/75 (32%), Positives = 35/75 (46%), Gaps = 1/75 (1%)

Query: 223 IYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYC-TVNNDEGEWSGPPP 281
           I C +PP I NG I            + Y+C+  F +IGE S+ C T +  +G W  P P
Sbjct: 21  ISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAP 80

Query: 282 ECRGKSLTSKVPPTV 296
           +C   +  S  P  +
Sbjct: 81  KCEYFNKYSSCPEPI 95



 Score = 32.0 bits (71), Expect = 0.95
 Identities = 18/67 (26%), Positives = 28/67 (41%), Gaps = 2/67 (2%)

Query: 35   DCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFC 94
            +C  P D+   Q  LE R  +    V+T +CE+ ++ + G   S  C    QW+     C
Sbjct: 970  NCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYM-LEGSPQSQ-CQSDHQWNPPLAVC 1027

Query: 95   NRSCEVP 101
                  P
Sbjct: 1028 RSRSLAP 1034


>gi|148886654 polydom [Homo sapiens]
          Length = 3571

 Score =  116 bits (291), Expect = 3e-26
 Identities = 81/279 (29%), Positives = 127/279 (45%), Gaps = 33/279 (11%)

Query: 28   CLPAVWGD---------CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDS 78
            C+P   GD         C  P +  N   + E  T   E   +T+ C+E +  +   K  
Sbjct: 1772 CVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAE---VTFSCQEGYQLMGVTK-- 1826

Query: 79   VICLKGSQWSDIEEFCNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREP 137
            + CL+  +W+ +  +C   SC  P     A  +   I +  F  G+ V Y C  GY    
Sbjct: 1827 ITCLESGEWNHLIPYCKAVSCGKP-----AIPENGCIEELAFTFGSKVTYRCNKGYTLAG 1881

Query: 138  SLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLF 197
                + +CL N  WS +   C+   C +P  I NG+  +  G+ + +T S+SC+TGY L 
Sbjct: 1882 D--KESSCLANSSWSHSPPVCEPVKCSSPENINNGKY-ILSGLTYLSTASYSCDTGYSLQ 1938

Query: 198  GSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGF 257
            G +   C  SG    W    P C  ++C  PP I + +I G  +++ +R +VTY C +G+
Sbjct: 1939 GPSIIECTASGI---WDRAPPACHLVFCGEPPAIKDAVITG--NNFTFRNTVTYTCKEGY 1993

Query: 258  TMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTV 296
            T+ G  +I C     +G+WS    +C   S     PP V
Sbjct: 1994 TLAGLDTIECLA---DGKWSRSDQQCLAVSCDE--PPIV 2027



 Score =  110 bits (275), Expect = 2e-24
 Identities = 76/277 (27%), Positives = 123/277 (44%), Gaps = 20/277 (7%)

Query: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCN 95
            C  PP V  +      +  F   +V+++KC E FV     K  + C++G QW+      +
Sbjct: 2083 CEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAK--IECMRGGQWNPSP--MS 2138

Query: 96   RSCEVPTRLNSA-SLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTA 154
              C +P R     S+   Y + + +  G +V Y C  G+  +     K TC    +WS+ 
Sbjct: 2139 IQC-IPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGE--KKSTCEATGQWSSP 2195

Query: 155  VEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWS 214
            +  C   SC  P ++ NG ++   G +F + + + CN GYK  GS    C    ++  W 
Sbjct: 2196 IPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVC---QANRHWH 2252

Query: 215  DPLP-ECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDE 273
               P  C  + C  PP I NG ++GE    G    V + CN+G+ ++G+ S  C      
Sbjct: 2253 SESPLMCVPLDCGKPPPIQNGFMKGENFEVG--SKVQFFCNEGYELVGDSSWTC---QKS 2307

Query: 274  GEWSGPP-PECRGKSLTSKVPPTVQKPTTVNVPTTEV 309
            G+W+    P+C         PP ++    +   TTEV
Sbjct: 2308 GKWNKKSNPKCMPAKCPE--PPLLENQLVLKELTTEV 2342



 Score =  110 bits (275), Expect = 2e-24
 Identities = 79/263 (30%), Positives = 128/263 (48%), Gaps = 29/263 (11%)

Query: 26   LLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGS 85
            L+C+P    DCG PP + N    ++G  +F   + + + C E + ++ G+  S  C K  
Sbjct: 2257 LMCVPL---DCGKPPPIQNG--FMKGE-NFEVGSKVQFFCNEGY-ELVGDS-SWTCQKSG 2308

Query: 86   QWSDIE--EFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRRE-PSLSPK 142
            +W+     +     C  P  L +  + +   T+    VG VV + C+ G+  + PS+   
Sbjct: 2309 KWNKKSNPKCMPAKCPEPPLLENQLVLKELTTE----VG-VVTFSCKEGHVLQGPSV--- 2360

Query: 143  LTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGIL-FGATISFSCNTGYKLFGSTS 201
            L CL + +W+ +   CK   C  P  I  G + +P   L FG+T+ +SC  G+ L G+++
Sbjct: 2361 LKCLPSQQWNDSFPVCKIVLCTPPPLISFG-VPIPSSALHFGSTVKYSCVGGFFLRGNST 2419

Query: 202  SFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIG 261
            + C   G+   WS PLPEC  + CP P +I NGII  +     Y  +  Y C  GF ++G
Sbjct: 2420 TLCQPDGT---WSSPLPECVPVECPQPEEIPNGII--DVQGLAYLSTALYTCKPGFELVG 2474

Query: 262  EHSIYCTVNNDEGEWSGPPPECR 284
              +  C    + G W G  P C+
Sbjct: 2475 NTTTLC---GENGHWLGGKPTCK 2494



 Score =  108 bits (270), Expect = 8e-24
 Identities = 67/232 (28%), Positives = 109/232 (46%), Gaps = 19/232 (8%)

Query: 53   TSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFC-NRSCEVPTRLNSASLKQ 111
            ++F   T+++Y C   +  +      +IC +   W+     C +  C++PT   +  L+ 
Sbjct: 2673 SNFLYGTMVSYTCNPGYELLGNPV--LICQEDGTWNGSAPSCISIECDLPTAPENGFLR- 2729

Query: 112  PYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRN 171
               T+    +G+ V+Y C+PG+    S      CL+N KWS A   C+  SC  P  + N
Sbjct: 2730 --FTET--SMGSAVQYSCKPGHILAGS--DLRLCLENRKWSGASPRCEAISCKKPNPVMN 2783

Query: 172  GQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQI 231
            G I       + +T+ + C+ GY L G+    C        W +  P C  + C +PP  
Sbjct: 2784 GSIK-GSNYTYLSTLYYECDPGYVLNGTERRTC---QDDKNWDEDEPICIPVDCSSPPVS 2839

Query: 232  DNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPEC 283
             NG ++G  D Y +++ + Y CN+GF + G  S  C  N   G WSG  P+C
Sbjct: 2840 ANGQVRG--DEYTFQKEIEYTCNEGFLLEGARSRVCLAN---GSWSGATPDC 2886



 Score =  107 bits (266), Expect = 2e-23
 Identities = 73/254 (28%), Positives = 113/254 (44%), Gaps = 28/254 (11%)

Query: 35   DCGLPPDVPNAQPALEGRTSFPEDTV---ITYKCEESFVKIPGEKDSVICLKGSQWSDIE 91
            +C LP    N      G   F E ++   + Y C+   +      D  +CL+  +WS   
Sbjct: 2716 ECDLPTAPEN------GFLRFTETSMGSAVQYSCKPGHIL--AGSDLRLCLENRKWSGAS 2767

Query: 92   EFCNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLK 150
              C   SC+ P  + + S+K      NY  + T+  YEC PGY    +   + TC  +  
Sbjct: 2768 PRCEAISCKKPNPVMNGSIKG----SNYTYLSTLY-YECDPGYVLNGT--ERRTCQDDKN 2820

Query: 151  WSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSS 210
            W      C    C +P    NGQ+       F   I ++CN G+ L G+ S  CL +GS 
Sbjct: 2821 WDEDEPICIPVDCSSPPVSANGQVR-GDEYTFQKEIEYTCNEGFLLEGARSRVCLANGS- 2878

Query: 211  VQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVN 270
              WS   P+C  + C  PPQ+ NG+ +G    YG+ + VT+ C++G+ + G   + C   
Sbjct: 2879 --WSGATPDCVPVRCATPPQLANGVTEGL--DYGFMKEVTFHCHEGYILHGAPKLTC--- 2931

Query: 271  NDEGEWSGPPPECR 284
              +G W    P C+
Sbjct: 2932 QSDGNWDAEIPLCK 2945



 Score =  100 bits (248), Expect = 3e-21
 Identities = 68/248 (27%), Positives = 111/248 (44%), Gaps = 17/248 (6%)

Query: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCN 95
            C LP ++ +    L     F  +  ++  C E +    G   SV  L G+ W     F +
Sbjct: 3181 CPLPENITHI---LVHGDDFSVNRQVSVSCAEGYT-FEGVNISVCQLDGT-WEP--PFSD 3233

Query: 96   RSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAV 155
             SC   +     S +  ++  + +   + + Y+C PGY  E +   +  C +N +WS  V
Sbjct: 3234 ESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNR--ERVCQENRQWSGGV 3291

Query: 156  EFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSD 215
              CK+  C  P E  NG+ D+      G  + +SCN GY L G + + C  +G+   WS 
Sbjct: 3292 AICKETRCETPLEFLNGKADIENRTT-GPNVVYSCNRGYSLEGPSEAHCTENGT---WSH 3347

Query: 216  PLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGE 275
            P+P C+   CP P  I    +  E++ Y   Q+V+  C +GF + G   I C   N +  
Sbjct: 3348 PVPLCKPNPCPVPFVIPENALLSEKEFY-VDQNVSIKCREGFLLQGHGIITC---NPDET 3403

Query: 276  WSGPPPEC 283
            W+    +C
Sbjct: 3404 WTQTSAKC 3411



 Score = 99.8 bits (247), Expect = 4e-21
 Identities = 81/267 (30%), Positives = 113/267 (42%), Gaps = 30/267 (11%)

Query: 27   LCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQ 86
            +C+P    DC  PP   N Q   +  T   E   I Y C E F+ + G + S +CL    
Sbjct: 2827 ICIPV---DCSSPPVSANGQVRGDEYTFQKE---IEYTCNEGFL-LEGAR-SRVCLANGS 2878

Query: 87   WSDIEEFCNRSCEVPTRLNSASLKQPYITQNY-FPVGTVVEYECRPGYRREPSLSPKLTC 145
            WS     C     VP R  +       +T+   +     V + C  GY    +  PKLTC
Sbjct: 2879 WSGATPDC-----VPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGA--PKLTC 2931

Query: 146  LQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILF--GATISFSCNTGYKLFGSTSSF 203
              +  W   +  CK  +C  P ++ +G    P G  F  G  I + C  GYKL G++S  
Sbjct: 2932 QSDGNWDAEIPLCKPVNCGPPEDLAHG---FPNGFSFIHGGHIQYQCFPGYKLHGNSSRR 2988

Query: 204  CLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEH 263
            CL +GS   WS   P C    C + P I+ G + G     G  ++    C KGF ++G  
Sbjct: 2989 CLSNGS---WSGSSPSCLPCRC-STPVIEYGTVNGTDFDCG--KAARIQCFKGFKLLGLS 3042

Query: 264  SIYCTVNNDEGEWSGPPPECRGKSLTS 290
             I C     +G+WS   P C   S  S
Sbjct: 3043 EITCEA---DGQWSSGFPHCEHTSCGS 3066



 Score = 93.6 bits (231), Expect = 3e-19
 Identities = 72/269 (26%), Positives = 111/269 (41%), Gaps = 30/269 (11%)

Query: 25   VLLCLPAV-WGD---------CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPG 74
            VL CLP+  W D         C  PP +    P       F   + + Y C   F  + G
Sbjct: 2360 VLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHF--GSTVKYSCVGGFF-LRG 2416

Query: 75   EKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYR 134
               ++    G+  S + E     C  P  + +  +      Q    + T + Y C+PG+ 
Sbjct: 2417 NSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIID----VQGLAYLSTAL-YTCKPGFE 2471

Query: 135  REPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGY 194
               + +    C +N  W      CK   C  P EI NG+      + +G T+++SCN G+
Sbjct: 2472 LVGNTTT--LCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTD-LHYGQTVTYSCNRGF 2528

Query: 195  KLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACN 254
            +L G ++  CL +G    W    P C  I+C +P  I+NG ++G    Y Y   + Y+C 
Sbjct: 2529 RLEGPSALTCLETGD---WDVDAPSCNAIHCDSPQPIENGFVEGA--DYSYGAIIIYSCF 2583

Query: 255  KGFTMIGEHSIYCTVNNDEGEWSGPPPEC 283
             GF + G     C    +E  WS   P C
Sbjct: 2584 PGFQVAGHAMQTC----EESGWSSSIPTC 2608



 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 74/302 (24%), Positives = 111/302 (36%), Gaps = 70/302 (23%)

Query: 28   CLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQW 87
            C+P    +C  P ++PN    ++G       +   Y C+  F  +     + +C +   W
Sbjct: 2435 CVPV---ECPQPEEIPNGIIDVQGLAYL---STALYTCKPGFELVGNT--TTLCGENGHW 2486

Query: 88   SDIEEFCNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRRE-PSLSPKLTC 145
               +  C    C  P  + +   K  Y   +Y   G  V Y C  G+R E PS    LTC
Sbjct: 2487 LGGKPTCKAIECLKPKEILNG--KFSYTDLHY---GQTVTYSCNRGFRLEGPSA---LTC 2538

Query: 146  LQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCL 205
            L+   W      C    C +P  I NG ++      +GA I +SC  G+++ G     C 
Sbjct: 2539 LETGDWDVDAPSCNAIHCDSPQPIENGFVE-GADYSYGAIIIYSCFPGFQVAGHAMQTCE 2597

Query: 206  ISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQS----------------- 248
             SG    WS  +P C  I C  PP ID G     +D  GY +                  
Sbjct: 2598 ESG----WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYH 2653

Query: 249  ---------------------------VTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPP 281
                                       V+Y CN G+ ++G   + C    ++G W+G  P
Sbjct: 2654 LGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLIC---QEDGTWNGSAP 2710

Query: 282  EC 283
             C
Sbjct: 2711 SC 2712



 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 68/247 (27%), Positives = 99/247 (40%), Gaps = 23/247 (9%)

Query: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCN 95
            CG  P+ P     +  + +F  ++ I Y+CE  + ++ G ++ V C +  QWS     C 
Sbjct: 3241 CG-KPESPEHGFVVGSKYTF--ESTIIYQCEPGY-ELEGNRERV-CQENRQWSGGVAICK 3295

Query: 96   RS-CEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRRE-PSLSPKLTCLQNLKWST 153
             + CE P    +        T      G  V Y C  GY  E PS   +  C +N  WS 
Sbjct: 3296 ETRCETPLEFLNGKADIENRT-----TGPNVVYSCNRGYSLEGPS---EAHCTENGTWSH 3347

Query: 154  AVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQW 213
             V  CK   CP P  I    +           +S  C  G+ L G     C        W
Sbjct: 3348 PVPLCKPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITC---NPDETW 3404

Query: 214  SDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDE 273
            +    +C +I C  P  ++N I +G   HY Y   +TY+C  G+ + G     C  N   
Sbjct: 3405 TQTSAKCEKISCGPPAHVENAIARGV--HYQYGDMITYSCYSGYMLEGFLRSVCLEN--- 3459

Query: 274  GEWSGPP 280
            G W+ PP
Sbjct: 3460 GTWTSPP 3466



 Score = 86.7 bits (213), Expect = 3e-17
 Identities = 69/247 (27%), Positives = 97/247 (39%), Gaps = 62/247 (25%)

Query: 81   CLKGSQWSDIEEFCNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSL 139
            CL   QW+     C R SC VP  L +      + + + F  G+ V Y+C  GY      
Sbjct: 1672 CLNQGQWTQPLPHCERISCGVPPPLENG-----FHSADDFYAGSTVTYQCNNGYYLLG-- 1724

Query: 140  SPKLTCLQNLKWSTAVEFC-------------KKKSCPN--------------------- 165
              ++ C  N  W+     C             +  SC N                     
Sbjct: 1725 DSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCA 1784

Query: 166  -------PGEIRNGQIDVPGGILF--GATISFSCNTGYKLFGSTSSFCLISGSSVQWSDP 216
                   PG   NG      G ++  GA ++FSC  GY+L G T   CL SG   +W+  
Sbjct: 1785 EPIKCKAPGNPENGH---SSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESG---EWNHL 1838

Query: 217  LPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEW 276
            +P C+ + C  P   +NG I  E   + +   VTY CNKG+T+ G+    C  N+    W
Sbjct: 1839 IPYCKAVSCGKPAIPENGCI--EELAFTFGSKVTYRCNKGYTLAGDKESSCLANS---SW 1893

Query: 277  SGPPPEC 283
            S  PP C
Sbjct: 1894 SHSPPVC 1900



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 70/253 (27%), Positives = 102/253 (40%), Gaps = 25/253 (9%)

Query: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCN 95
            CG  P +PNA       TS  ++ VITY C   +V I G  D +IC +   WS     C 
Sbjct: 3064 CGSLPMIPNA---FISETSSWKENVITYSCRSGYV-IQGSSD-LICTEKGVWSQPYPVCE 3118

Query: 96   R-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTA 154
              SC  P  + +A       T       + V+  C  GY  +   +   TC ++ +W   
Sbjct: 3119 PLSCGSPPSVANA-----VATGEAHTYESEVKLRCLEGYTMDTD-TDTFTCQKDGRWFPE 3172

Query: 155  VEFCKKKSCPNPGEIRNGQIDVPG-GILFGATISFSCNTGYKLFGSTSSFCLISGSSVQW 213
               C  K CP P  I +  I V G        +S SC  GY   G   S C + G+   W
Sbjct: 3173 RISCSPKKCPLPENITH--ILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGT---W 3227

Query: 214  SDPLPE--CREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNN 271
              P  +  C  + C  P   ++G + G +  Y +  ++ Y C  G+ + G     C  N 
Sbjct: 3228 EPPFSDESCSPVSCGKPESPEHGFVVGSK--YTFESTIIYQCEPGYELEGNRERVCQENR 3285

Query: 272  DEGEWSGPPPECR 284
               +WSG    C+
Sbjct: 3286 ---QWSGGVAICK 3295



 Score = 82.8 bits (203), Expect = 5e-16
 Identities = 36/101 (35%), Positives = 57/101 (56%), Gaps = 8/101 (7%)

Query: 183  GATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDH 242
            G+ ++  C+ G++L G+   +CL  G   QW+ PLP C  I C  PP ++NG    +  +
Sbjct: 1651 GSKVNLFCDPGFQLVGNPVQYCLNQG---QWTQPLPHCERISCGVPPPLENGFHSADDFY 1707

Query: 243  YGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPEC 283
             G   +VTY CN G+ ++G+  ++CT   D G W+G  P C
Sbjct: 1708 AG--STVTYQCNNGYYLLGDSRMFCT---DNGSWNGVSPSC 1743



 Score = 82.4 bits (202), Expect = 6e-16
 Identities = 69/260 (26%), Positives = 106/260 (40%), Gaps = 23/260 (8%)

Query: 27   LCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQ 86
            LC P    +CG P D+ +  P      SF     I Y+C   + K+ G   S  CL    
Sbjct: 2943 LCKPV---NCGPPEDLAHGFP---NGFSFIHGGHIQYQCFPGY-KLHGNS-SRRCLSNGS 2994

Query: 87   WSDIEEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCL 146
            WS     C     +P R ++  ++   +    F  G     +C  G++    LS ++TC 
Sbjct: 2995 WSGSSPSC-----LPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLL-GLS-EITCE 3047

Query: 147  QNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLI 206
             + +WS+    C+  SC +   I N  I           I++SC +GY + GS+   C  
Sbjct: 3048 ADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWKENV-ITYSCRSGYVIQGSSDLICTE 3106

Query: 207  SGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIY 266
             G    WS P P C  + C +PP + N +  GE   + Y   V   C +G+TM  +   +
Sbjct: 3107 KGV---WSQPYPVCEPLSCGSPPSVANAVATGEA--HTYESEVKLRCLEGYTMDTDTDTF 3161

Query: 267  CTVNNDEGEWSGPPPECRGK 286
                  +G W      C  K
Sbjct: 3162 TC--QKDGRWFPERISCSPK 3179



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 51/174 (29%), Positives = 76/174 (43%), Gaps = 11/174 (6%)

Query: 110  KQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEI 169
            + P    + F  GT+V Y C PGY  E   +P L C ++  W+ +   C    C  P   
Sbjct: 2666 ESPATHSSNFLYGTMVSYTCNPGY--ELLGNPVLICQEDGTWNGSAPSCISIECDLPTAP 2723

Query: 170  RNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPP 229
             NG +      + G+ + +SC  G+ L GS    CL    + +WS   P C  I C  P 
Sbjct: 2724 ENGFLRFTETSM-GSAVQYSCKPGHILAGSDLRLCL---ENRKWSGASPRCEAISCKKPN 2779

Query: 230  QIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPEC 283
             + NG I+G   +Y Y  ++ Y C+ G+ + G     C    D+  W    P C
Sbjct: 2780 PVMNGSIKG--SNYTYLSTLYYECDPGYVLNGTERRTC---QDDKNWDEDEPIC 2828



 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 62/268 (23%), Positives = 104/268 (38%), Gaps = 27/268 (10%)

Query: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVI-CLKGSQWSDIEEFC 94
            C  P ++ N +  L G T     +  +Y C+  +     +  S+I C     W      C
Sbjct: 1905 CSSPENINNGKYILSGLTYL---STASYSCDTGYSL---QGPSIIECTASGIWDRAPPAC 1958

Query: 95   NRS-CEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWST 153
            +   C  P      ++K   IT N F     V Y C+ GY         + CL + KWS 
Sbjct: 1959 HLVFCGEPP-----AIKDAVITGNNFTFRNTVTYTCKEGYTLAGL--DTIECLADGKWSR 2011

Query: 154  AVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQW 213
            + + C   SC  P  + +   +     LFG    + C+ GY L  ++   C   G   +W
Sbjct: 2012 SDQQCLAVSCDEPPIVDHASPETAHR-LFGDIAFYYCSDGYSLADNSQLLCNAQG---KW 2067

Query: 214  SDP----LPECREIYCPAPPQIDNGIIQG-ERDHYGYRQSVTYACNKGFTMIGEHSIYCT 268
              P    +P C   +C  PP +   I++   +  +     V++ C +GF +     I C 
Sbjct: 2068 VPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECM 2127

Query: 269  VNNDEGEWSGPPPECRGKSLTSKVPPTV 296
                 G+W+  P   +   +    PP++
Sbjct: 2128 RG---GQWNPSPMSIQCIPVRCGEPPSI 2152



 Score = 69.3 bits (168), Expect = 5e-12
 Identities = 71/302 (23%), Positives = 110/302 (36%), Gaps = 64/302 (21%)

Query: 122  GTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGIL 181
            G+ V   C PG++   +  P   CL   +W+  +  C++ SC  P  + NG         
Sbjct: 1651 GSKVNLFCDPGFQLVGN--PVQYCLNQGQWTQPLPHCERISCGVPPPLENG-FHSADDFY 1707

Query: 182  FGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECRE------------------- 222
             G+T+++ CN GY L G +  FC  +GS   W+   P C +                   
Sbjct: 1708 AGSTVTYQCNNGYYLLGDSRMFCTDNGS---WNGVSPSCLDVDECAVGSDCSEHASCLNV 1764

Query: 223  ----------------------IYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMI 260
                                  I C AP   +NG   GE   Y     VT++C +G+ ++
Sbjct: 1765 DGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGE--IYTVGAEVTFSCQEGYQLM 1822

Query: 261  GEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVNVPTTEVSPTSQKTTTKT 320
            G   I C    + GEW+   P C  K+++   P   +      +  T  S  + +     
Sbjct: 1823 GVTKITCL---ESGEWNHLIPYC--KAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGY 1877

Query: 321  T---------TPNAQATRSTPVSRTTKHFHETTPNKGSGTTSGTTRL-LSGHTCFTLTGL 370
            T           N+  + S PV    K       N G    SG T L  + ++C T   L
Sbjct: 1878 TLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSGLTYLSTASYSCDTGYSL 1937

Query: 371  LG 372
             G
Sbjct: 1938 QG 1939



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 41/147 (27%), Positives = 61/147 (41%), Gaps = 8/147 (5%)

Query: 138 SLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQ-IDVPGGILFGATISFSCNTGYKL 196
           S SP+  C+    +  + + C+   CP      NG  I       F A     C+ G+ L
Sbjct: 354 STSPE-DCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDL 412

Query: 197 FGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKG 256
            GS+   CL +G    WS     CR   CP   Q  +G I        Y+ +   AC++G
Sbjct: 413 VGSSIILCLPNGL---WSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEG 469

Query: 257 FTMIGEHSIYCTVNNDEGEWSGPPPEC 283
           + + G   + C  N+   +W GP P C
Sbjct: 470 YRLEGSDKLTCQGNS---QWDGPEPRC 493



 Score = 34.7 bits (78), Expect = 0.15
 Identities = 41/162 (25%), Positives = 60/162 (37%), Gaps = 28/162 (17%)

Query: 79  VICLKGSQWSDIEEFCN-RSCEVPTRLNSASLKQPY-----ITQNYFPVGTVVEYECRPG 132
           ++CL    WS  E +C  R+C          L+QP       +       T     C  G
Sbjct: 418 ILCLPNGLWSGSESYCRVRTCP--------HLRQPKHGHISCSTREMLYKTTCLVACDEG 469

Query: 133 YRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGG-----ILFGATIS 187
           YR E S   KLTC  N +W      C ++ C +  ++    I  P         FG    
Sbjct: 470 YRLEGS--DKLTCQGNSQWDGPEPRCVERHC-STFQMPKDVIISPHNCGKQPAKFGTICY 526

Query: 188 FSCNTGYKLFGSTSSF-CLISGSSVQWSDPLPE--CREIYCP 226
            SC  G+ L G      C  SG   +W+  +    C+++  P
Sbjct: 527 VSCRQGFILSGVKEMLRCTTSG---KWNVGVQAAVCKDVEAP 565


>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
          Length = 3667

 Score =  108 bits (269), Expect = 1e-23
 Identities = 81/256 (31%), Positives = 111/256 (43%), Gaps = 24/256 (9%)

Query: 34   GDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEF 93
            G CG+P  + N Q  + G      DTV+ Y+C   F  I       IC +   WS     
Sbjct: 2775 GHCGIPELIVNGQ--VIGENYGYRDTVV-YQCNPGFRLIGSSVR--ICQQDHNWSGQLPS 2829

Query: 94   CNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWS 152
            C   SC  P      S      + N F    VV + C  GY  +     K  C  N +WS
Sbjct: 2830 CVPVSCGHP-----GSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPT--KAQCQANRQWS 2882

Query: 153  TAVEFCKKKSCPNPGEIRNGQIDVP---GGILFGATISFSCNTGYKLFGSTSSFCLISGS 209
                 CK  +C +PG   N + +     G   +G  + + CN GY LFGS+   C  +G 
Sbjct: 2883 HPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNG- 2941

Query: 210  SVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTV 269
              QW  PLPEC  I C  P    N ++ GE+  Y +  +V Y+C    +++G+ S  C +
Sbjct: 2942 --QWDKPLPECIMIDCGHPGVPPNAVLSGEK--YTFGSTVHYSCTGKRSLLGQSSRTCQL 2997

Query: 270  NNDEGEWSGPPPECRG 285
            N   G WSG  P C G
Sbjct: 2998 N---GHWSGSQPHCSG 3010



 Score =  105 bits (261), Expect = 9e-23
 Identities = 87/288 (30%), Positives = 120/288 (41%), Gaps = 38/288 (13%)

Query: 25   VLLCLP----------AVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPG 74
            VL+C P           +  DCG P   PNA   L G   +   + + Y C      +  
Sbjct: 2934 VLICQPNGQWDKPLPECIMIDCGHPGVPPNA--VLSGE-KYTFGSTVHYSCTGKRSLLG- 2989

Query: 75   EKDSVICLKGSQWSDIEEFCNR----SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECR 130
             + S  C     WS  +  C+     +C  P      S ++     + F   + V Y C 
Sbjct: 2990 -QSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQE-----SNFRTKSTVRYACD 3043

Query: 131  PGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSC 190
             GY    S   + TCL N  W+     CK   C NPG   NG++    G  F +++ +SC
Sbjct: 3044 TGYILHGS--EERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSC 3101

Query: 191  NTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVT 250
              GY L G +   C  +G+   WS  LP C  I C  P    NG+  G  D Y   Q+V+
Sbjct: 3102 MEGYILSGPSVRQCTANGT---WSGTLPNCTIISCGDPGIPANGLRYG--DDYVVGQNVS 3156

Query: 251  YACNKGFTM--IGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTV 296
            Y C  G+TM   G     CT+N   G WSG  P CR  ++T   PP +
Sbjct: 3157 YMCQPGYTMELNGSRIRTCTIN---GTWSGVMPTCR--AVTCPTPPQI 3199



 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 78/256 (30%), Positives = 110/256 (42%), Gaps = 25/256 (9%)

Query: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCN 95
            CG+P    N        T +   T +TY C + +     E  + +C     WS+  +   
Sbjct: 2592 CGIPKAPTNGGILT---TDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNK--T 2646

Query: 96   RSCEVPT--RLNSASLKQP---YITQNYFPVGTVVEYECRPGYRREPSLSP-KLTCLQNL 149
              C V T   +NS  L+      +  +++   T V + C PGY     L P  + CL N 
Sbjct: 2647 PRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYH---GLGPASIECLPNG 2703

Query: 150  KWSTAVE--FCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLIS 207
             WS   E  +C+  SC       NG   +     +G+T  F+C+ G+ L GS    CL S
Sbjct: 2704 TWSWRNERPYCQIISCGELPTPPNGN-KIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSS 2762

Query: 208  GSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYC 267
            G    WS+    C   +C  P  I NG + GE  +YGYR +V Y CN GF +IG     C
Sbjct: 2763 GL---WSESETRCLAGHCGIPELIVNGQVIGE--NYGYRDTVVYQCNPGFRLIGSSVRIC 2817

Query: 268  TVNNDEGEWSGPPPEC 283
                 +  WSG  P C
Sbjct: 2818 ---QQDHNWSGQLPSC 2830



 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 79/274 (28%), Positives = 120/274 (43%), Gaps = 29/274 (10%)

Query: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKI-PGEKDSVICLKGSQWSDIEEFC 94
            CG P    N +      T+F    +  Y C E ++   P  +    C     WS     C
Sbjct: 3074 CGNPGTTANGKVFRIDGTTFSSSVI--YSCMEGYILSGPSVRQ---CTANGTWSGTLPNC 3128

Query: 95   NR-SCEVP-TRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWS 152
               SC  P    N       Y+      VG  V Y C+PGY  E + S   TC  N  WS
Sbjct: 3129 TIISCGDPGIPANGLRYGDDYV------VGQNVSYMCQPGYTMELNGSRIRTCTINGTWS 3182

Query: 153  TAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQ 212
              +  C+  +CP P +I NG+++      +G +IS+ C+ GY+L       C+ +G+   
Sbjct: 3183 GVMPTCRAVTCPTPPQISNGRLE-GTNFDWGFSISYICSPGYELSFPAVLTCVGNGT--- 3238

Query: 213  WSDPLPECREIYCPAPPQIDNGI-IQGERD--HYGYRQSVTYACNKGFTMIGEHSIYCTV 269
            WS  +P+C   +C  P     GI  QG+R+   + Y+  V+++CN  F ++G  +  C  
Sbjct: 3239 WSGEVPQCLPKFCGDP-----GIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQA 3293

Query: 270  NNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVN 303
               +G WSG  P C   + TS   P V +  + N
Sbjct: 3294 ---DGTWSGSSPHCIEPTQTSCENPGVPRHGSQN 3324



 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 59/212 (27%), Positives = 89/212 (41%), Gaps = 33/212 (15%)

Query: 16   GELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGE 75
            GE+P+       CLP   GD G+P     AQ   EG+ SF   + +++ C   F+ +   
Sbjct: 3241 GEVPQ-------CLPKFCGDPGIP-----AQGKREGK-SFIYQSEVSFSCNFPFILVGSS 3287

Query: 76   KDSVICLKGSQWSDIEEFC----NRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRP 131
              + IC     WS     C      SCE P      S    +     F VG+VV++ C+ 
Sbjct: 3288 --TRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTF----GFQVGSVVQFHCKK 3341

Query: 132  GYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQI---DVPGGILFGATISF 188
            G+  + S +   TCL +L WS     C   SC  P    +  +   D+P     G T+ +
Sbjct: 3342 GHLLQGSTTR--TCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPS---HGYTLIY 3396

Query: 189  SCNTGYKLFGSTSSFCLISGSSVQWSDPLPEC 220
            +C  G+ L G T     +  S   W+  +P C
Sbjct: 3397 TCQPGFFLAGGTEH--RVCRSDNTWTGKVPIC 3426



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 73/275 (26%), Positives = 112/275 (40%), Gaps = 32/275 (11%)

Query: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESF-VKIPGEKDSVICLKGSQWS-DIEEF 93
            C  PP + N +  LEG T+F     I+Y C   + +  P     + C+    WS ++ + 
Sbjct: 3193 CPTPPQISNGR--LEG-TNFDWGFSISYICSPGYELSFPAV---LTCVGNGTWSGEVPQC 3246

Query: 94   CNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWST 153
              + C  P         Q       F   + V + C   +    S +    C  +  WS 
Sbjct: 3247 LPKFCGDP-----GIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTR--ICQADGTWSG 3299

Query: 154  AVEFC---KKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSS 210
            +   C    + SC NPG  R+G  +   G   G+ + F C  G+ L GST+  CL     
Sbjct: 3300 SSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCL---PD 3356

Query: 211  VQWSDPLPECREIYCPAPPQIDNGIIQG-ERDHYGYRQSVTYACNKGFTMIG--EHSIYC 267
            + WS   PEC    C  P    +  + G +   +GY  ++ Y C  GF + G  EH + C
Sbjct: 3357 LTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGY--TLIYTCQPGFFLAGGTEHRV-C 3413

Query: 268  TVNNDEGEWSGPPPECR-GKSLTSKVP-PTVQKPT 300
              +N    W+G  P C  G  +  K P P +  P+
Sbjct: 3414 RSDN---TWTGKVPICEAGSKILVKDPRPALGTPS 3445



 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 34/85 (40%), Positives = 42/85 (49%), Gaps = 5/85 (5%)

Query: 161  KSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPEC 220
            +SCP+P   RNG + +      G TISF C  GY L G+++  CL  G S  W+ PLP C
Sbjct: 2182 QSCPDPRPFRNGFV-IGNDFTVGQTISFECFPGYTLIGNSALTCL-HGVSRNWNHPLPRC 2239

Query: 221  REIYCPAPPQIDNGII--QGERDHY 243
             E  C       NG I   G  D Y
Sbjct: 2240 -EALCGGNITAMNGTIYSPGYPDEY 2263



 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 36/124 (29%), Positives = 52/124 (41%), Gaps = 6/124 (4%)

Query: 163  CPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQ-WSDPLPECR 221
            C  P    +G I    G    + + ++C+ G++L G +S+ C  S      W  P+P C+
Sbjct: 2529 CSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2588

Query: 222  EIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWS--GP 279
             I C  P    NG I       G R  VTY CN G+  +    +   V   +G WS    
Sbjct: 2589 AISCGIPKAPTNGGILTTDYLVGTR--VTYFCNDGY-RLSSKELTTAVCQSDGTWSNHNK 2645

Query: 280  PPEC 283
             P C
Sbjct: 2646 TPRC 2649



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 30/75 (40%), Positives = 42/75 (56%), Gaps = 5/75 (6%)

Query: 163  CPNPGEIRNG-QIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECR 221
            C +PG  + G +I    GI  G T++FSC++GY+L G++   CL  G  V WS PLP C 
Sbjct: 1142 CEDPGIPQYGSRIGFNFGI--GDTLTFSCSSGYRLEGTSEIICLGGGRRV-WSAPLPRC- 1197

Query: 222  EIYCPAPPQIDNGII 236
               C A    + GI+
Sbjct: 1198 VAECGASATNNEGIL 1212



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 54/224 (24%), Positives = 77/224 (34%), Gaps = 56/224 (25%)

Query: 113  YITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLK--WSTAVEFCKKKSCPNPGEIR 170
            ++  N F VG  + +EC PGY    + +  LTCL  +   W+  +  C+   C       
Sbjct: 2194 FVIGNDFTVGQTISFECFPGYTLIGNSA--LTCLHGVSRNWNHPLPRCEAL-CGGNITAM 2250

Query: 171  NGQIDVPG---------------------GILFGATI----------------------- 186
            NG I  PG                     GI    T+                       
Sbjct: 2251 NGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPDQNSPQI 2310

Query: 187  -SFSCNTGYKLFGSTSSFCLIS-GSSVQWSDPLPECREIY----CPAPPQIDNGIIQGER 240
              FS NT  +   STS+  LI   S    S         Y    C  PP + N  I  E 
Sbjct: 2311 GQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQLRVCQPPPPVPNAEILTED 2370

Query: 241  DHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECR 284
            D +     + Y C  GFT++G   + C +  +  +  G PP C+
Sbjct: 2371 DEFEIGDIIRYQCLPGFTLVGNAILTCRL-GERLQMDGAPPVCQ 2413



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 26/73 (35%), Positives = 37/73 (50%), Gaps = 2/73 (2%)

Query: 163 CPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFC-LISGSSVQWSDPLPECR 221
           CP+PGE  NG+  +      G+T+ FSC+  Y L G+ S  C  I+     WSD  P C+
Sbjct: 446 CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 504

Query: 222 EIYCPAPPQIDNG 234
              C +  Q  +G
Sbjct: 505 VKTCGSNLQGPSG 517



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 22/58 (37%), Positives = 29/58 (50%), Gaps = 1/58 (1%)

Query: 163  CPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPEC 220
            C +PG  + G      G   G+TI + CN GY L GS+   C+ +G    W  PLP C
Sbjct: 1314 CEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCM-TGERRAWDYPLPSC 1370



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 30/89 (33%), Positives = 40/89 (44%), Gaps = 15/89 (16%)

Query: 156 EFCKKKSCPNPGEIRNGQIDVPGGILFGAT------ISFSCNTGYKLFGSTSSFCLI-SG 208
           E  +  SC NPG         P G+L+G        I +SC TGY L G     C+  S 
Sbjct: 131 EELQSSSCGNPGV-------PPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSV 183

Query: 209 SSVQWSDPLPECR-EIYCPAPPQIDNGII 236
           ++  W  P+P CR E  C    +  +GII
Sbjct: 184 NTASWDFPVPICRAEDACGGTMRGSSGII 212



 Score = 38.9 bits (89), Expect = 0.008
 Identities = 23/68 (33%), Positives = 32/68 (47%), Gaps = 2/68 (2%)

Query: 154  AVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFC-LISGSSVQ 212
            AV       C +  E R G+  +      G+++ F CN GY L GS +  C  +  S  Q
Sbjct: 1829 AVPRTSSTQCSSVPEPRFGR-RIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQ 1887

Query: 213  WSDPLPEC 220
            W+D LP C
Sbjct: 1888 WNDSLPTC 1895



 Score = 38.1 bits (87), Expect = 0.013
 Identities = 20/59 (33%), Positives = 30/59 (50%), Gaps = 2/59 (3%)

Query: 162  SCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPEC 220
            SCP P    +G I +    + G  +SF C+ GY L G +   C+  G   +W+ P+P C
Sbjct: 2011 SCPEPQTPSSG-IKIGDRYMVGDVVSFQCDQGYSLQGHSHITCM-PGPVRRWNYPIPIC 2067



 Score = 37.7 bits (86), Expect = 0.017
 Identities = 18/59 (30%), Positives = 30/59 (50%), Gaps = 3/59 (5%)

Query: 225  CPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPEC 283
            CP P    NG + G     G  Q++++ C  G+T+IG  ++ C ++     W+ P P C
Sbjct: 2184 CPDPRPFRNGFVIGNDFTVG--QTISFECFPGYTLIGNSALTC-LHGVSRNWNHPLPRC 2239



 Score = 37.0 bits (84), Expect = 0.030
 Identities = 23/63 (36%), Positives = 30/63 (47%), Gaps = 5/63 (7%)

Query: 239 ERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPP--TV 296
           E D +  R  + + C  GF +IGE SI C  NN   +WS   P C    L++   P  TV
Sbjct: 636 EGDGFSNRDVLRFECQFGFELIGEKSIVCQENN---QWSANIPICIFPCLSNFTAPMGTV 692

Query: 297 QKP 299
             P
Sbjct: 693 LSP 695



 Score = 36.6 bits (83), Expect = 0.039
 Identities = 19/62 (30%), Positives = 33/62 (53%), Gaps = 2/62 (3%)

Query: 160  KKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSS-VQWSDPLP 218
            ++SC +PG I NG   +      G+T+++ C+ GY L G ++  C++       W+  LP
Sbjct: 1658 RESCFDPGNIMNGT-RLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1716

Query: 219  EC 220
             C
Sbjct: 1717 SC 1718



 Score = 35.8 bits (81), Expect = 0.066
 Identities = 21/59 (35%), Positives = 30/59 (50%), Gaps = 4/59 (6%)

Query: 162  SCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPEC 220
            SC +PG   +G+         G+T+SFSC++GY+L       C     +  WS PLP C
Sbjct: 969  SCLDPGIPVHGR-RYGHDFSIGSTVSFSCDSGYRLSHEEPLLC---EKNHWWSHPLPTC 1023



 Score = 35.4 bits (80), Expect = 0.086
 Identities = 39/152 (25%), Positives = 59/152 (38%), Gaps = 20/152 (13%)

Query: 217  LPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYC-TVNNDEGE 275
            +P      C + P+   G   G  + +    SV + CN G+ + G  +I C TV N   +
Sbjct: 1830 VPRTSSTQCSSVPEPRFGRRIG--NEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQ 1887

Query: 276  WSGPPPEC---RGKSLTSKVPPTVQKPTTVNVPTTEVSPTSQKTTTKTTTPNAQATRSTP 332
            W+   P C    G  LT +      K T ++    E    +     K T P     +   
Sbjct: 1888 WNDSLPTCIVPCGGILTKR------KGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQV 1941

Query: 333  VSRTTKH------FHETTPNKGS--GTTSGTT 356
            VS  T+H      F++   N     G+ SGTT
Sbjct: 1942 VSFATEHNWDSLDFYDGGDNNAPRLGSYSGTT 1973



 Score = 33.9 bits (76), Expect = 0.25
 Identities = 27/106 (25%), Positives = 43/106 (40%), Gaps = 7/106 (6%)

Query: 178  GGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQ 237
            G  + G T+S + N  +  F S +         V  S  L  C +   P  PQ    I  
Sbjct: 1272 GASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCED---PGIPQFGYKI-- 1326

Query: 238  GERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPEC 283
             ++ H+    ++ Y CN G+T+ G   + C +  +   W  P P C
Sbjct: 1327 SDQGHFA-GSTIIYGCNPGYTLHGSSLLKC-MTGERRAWDYPLPSC 1370



 Score = 33.5 bits (75), Expect = 0.33
 Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 2/59 (3%)

Query: 163 CPNPGEIRNGQIDVPGGILFGATISFSCNTGY-KLFGSTSSFCLISGSSVQWSDPLPEC 220
           CP+PG   N +         G++IS  C  G+ K  G+ +  C++    V WS  +P+C
Sbjct: 794 CPDPGIPINAR-RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 851



 Score = 32.7 bits (73), Expect = 0.56
 Identities = 23/78 (29%), Positives = 35/78 (44%), Gaps = 8/78 (10%)

Query: 207  SGSSVQWSDPLPE-CREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSI 265
            SG ++Q+S  +   CR+   P  P   NG   G+    G   +V + C+ G+ + GE  I
Sbjct: 1474 SGFAIQFSSSVATACRD---PGVPM--NGTRNGDGREPG--DTVVFQCDPGYELQGEERI 1526

Query: 266  YCTVNNDEGEWSGPPPEC 283
             C    +   W   PP C
Sbjct: 1527 TCIQVENRYFWQPSPPVC 1544



 Score = 32.3 bits (72), Expect = 0.73
 Identities = 31/122 (25%), Positives = 53/122 (43%), Gaps = 19/122 (15%)

Query: 171  NGQIDVPGGILFGATISFSCNTGYKLFGS-------TSSFCL-ISGSSVQWSD-PLPECR 221
            NG    P   L G+ +  + N G  L+G+        S F +   G ++ +S+  L  C 
Sbjct: 1086 NGSFTQPLARLTGSDLPPTINAG--LYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCE 1143

Query: 222  EIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPP 281
            +   P  PQ  + I      ++G   ++T++C+ G+ + G   I C +      WS P P
Sbjct: 1144 D---PGIPQYGSRI----GFNFGIGDTLTFSCSSGYRLEGTSEIIC-LGGGRRVWSAPLP 1195

Query: 282  EC 283
             C
Sbjct: 1196 RC 1197



 Score = 32.0 bits (71), Expect = 0.95
 Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 3/59 (5%)

Query: 225  CPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPEC 283
            CP P    +GI  G+R  Y     V++ C++G+++ G   I C +      W+ P P C
Sbjct: 2012 CPEPQTPSSGIKIGDR--YMVGDVVSFQCDQGYSLQGHSHITC-MPGPVRRWNYPIPIC 2067



 Score = 30.4 bits (67), Expect = 2.8
 Identities = 18/59 (30%), Positives = 26/59 (44%), Gaps = 1/59 (1%)

Query: 162  SCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPEC 220
            +C +PG   NG  +  G    G T+ F C+ GY+L G     C+   +   W    P C
Sbjct: 1487 ACRDPGVPMNGTRNGDGREP-GDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1544


>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
            sapiens]
          Length = 3538

 Score =  108 bits (269), Expect = 1e-23
 Identities = 81/256 (31%), Positives = 111/256 (43%), Gaps = 24/256 (9%)

Query: 34   GDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEF 93
            G CG+P  + N Q  + G      DTV+ Y+C   F  I       IC +   WS     
Sbjct: 2646 GHCGIPELIVNGQ--VIGENYGYRDTVV-YQCNPGFRLIGSSVR--ICQQDHNWSGQLPS 2700

Query: 94   CNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWS 152
            C   SC  P      S      + N F    VV + C  GY  +     K  C  N +WS
Sbjct: 2701 CVPVSCGHP-----GSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPT--KAQCQANRQWS 2753

Query: 153  TAVEFCKKKSCPNPGEIRNGQIDVP---GGILFGATISFSCNTGYKLFGSTSSFCLISGS 209
                 CK  +C +PG   N + +     G   +G  + + CN GY LFGS+   C  +G 
Sbjct: 2754 HPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNG- 2812

Query: 210  SVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTV 269
              QW  PLPEC  I C  P    N ++ GE+  Y +  +V Y+C    +++G+ S  C +
Sbjct: 2813 --QWDKPLPECIMIDCGHPGVPPNAVLSGEK--YTFGSTVHYSCTGKRSLLGQSSRTCQL 2868

Query: 270  NNDEGEWSGPPPECRG 285
            N   G WSG  P C G
Sbjct: 2869 N---GHWSGSQPHCSG 2881



 Score =  105 bits (261), Expect = 9e-23
 Identities = 87/288 (30%), Positives = 120/288 (41%), Gaps = 38/288 (13%)

Query: 25   VLLCLP----------AVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPG 74
            VL+C P           +  DCG P   PNA   L G   +   + + Y C      +  
Sbjct: 2805 VLICQPNGQWDKPLPECIMIDCGHPGVPPNA--VLSGE-KYTFGSTVHYSCTGKRSLLG- 2860

Query: 75   EKDSVICLKGSQWSDIEEFCNR----SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECR 130
             + S  C     WS  +  C+     +C  P      S ++     + F   + V Y C 
Sbjct: 2861 -QSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQE-----SNFRTKSTVRYACD 2914

Query: 131  PGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSC 190
             GY    S   + TCL N  W+     CK   C NPG   NG++    G  F +++ +SC
Sbjct: 2915 TGYILHGS--EERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSC 2972

Query: 191  NTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVT 250
              GY L G +   C  +G+   WS  LP C  I C  P    NG+  G  D Y   Q+V+
Sbjct: 2973 MEGYILSGPSVRQCTANGT---WSGTLPNCTIISCGDPGIPANGLRYG--DDYVVGQNVS 3027

Query: 251  YACNKGFTM--IGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTV 296
            Y C  G+TM   G     CT+N   G WSG  P CR  ++T   PP +
Sbjct: 3028 YMCQPGYTMELNGSRIRTCTIN---GTWSGVMPTCR--AVTCPTPPQI 3070



 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 79/274 (28%), Positives = 120/274 (43%), Gaps = 29/274 (10%)

Query: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKI-PGEKDSVICLKGSQWSDIEEFC 94
            CG P    N +      T+F    +  Y C E ++   P  +    C     WS     C
Sbjct: 2945 CGNPGTTANGKVFRIDGTTFSSSVI--YSCMEGYILSGPSVRQ---CTANGTWSGTLPNC 2999

Query: 95   NR-SCEVP-TRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWS 152
               SC  P    N       Y+      VG  V Y C+PGY  E + S   TC  N  WS
Sbjct: 3000 TIISCGDPGIPANGLRYGDDYV------VGQNVSYMCQPGYTMELNGSRIRTCTINGTWS 3053

Query: 153  TAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQ 212
              +  C+  +CP P +I NG+++      +G +IS+ C+ GY+L       C+ +G+   
Sbjct: 3054 GVMPTCRAVTCPTPPQISNGRLE-GTNFDWGFSISYICSPGYELSFPAVLTCVGNGT--- 3109

Query: 213  WSDPLPECREIYCPAPPQIDNGI-IQGERD--HYGYRQSVTYACNKGFTMIGEHSIYCTV 269
            WS  +P+C   +C  P     GI  QG+R+   + Y+  V+++CN  F ++G  +  C  
Sbjct: 3110 WSGEVPQCLPKFCGDP-----GIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQA 3164

Query: 270  NNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVN 303
               +G WSG  P C   + TS   P V +  + N
Sbjct: 3165 ---DGTWSGSSPHCIEPTQTSCENPGVPRHGSQN 3195



 Score = 95.1 bits (235), Expect = 9e-20
 Identities = 77/255 (30%), Positives = 107/255 (41%), Gaps = 25/255 (9%)

Query: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQ----WSDIE 91
            C  P   P+    +  +T    ++V+ + C+  F ++ G K S +C K S     W    
Sbjct: 2465 CSTPESPPHGY--IISQTGGQLNSVVRWACDRGF-RLVG-KSSAVCRKSSYGYHAWDAPV 2520

Query: 92   EFCNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLK 150
              C   SC +P    +  +    +T +Y  VGT V Y C  GYR          C  +  
Sbjct: 2521 PACQAISCGIPKAPTNGGI----LTTDYL-VGTRVTYFCNDGYRLSSKELTTAVCQSDGT 2575

Query: 151  WST--AVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISG 208
            WS       C   SC       NG   +     +G+T  F+C+ G+ L GS    CL SG
Sbjct: 2576 WSNHNKTPRCVVISCGELPTPPNGN-KIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSG 2634

Query: 209  SSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCT 268
                WS+    C   +C  P  I NG + GE  +YGYR +V Y CN GF +IG     C 
Sbjct: 2635 L---WSESETRCLAGHCGIPELIVNGQVIGE--NYGYRDTVVYQCNPGFRLIGSSVRIC- 2688

Query: 269  VNNDEGEWSGPPPEC 283
                +  WSG  P C
Sbjct: 2689 --QQDHNWSGQLPSC 2701



 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 59/212 (27%), Positives = 89/212 (41%), Gaps = 33/212 (15%)

Query: 16   GELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGE 75
            GE+P+       CLP   GD G+P     AQ   EG+ SF   + +++ C   F+ +   
Sbjct: 3112 GEVPQ-------CLPKFCGDPGIP-----AQGKREGK-SFIYQSEVSFSCNFPFILVGSS 3158

Query: 76   KDSVICLKGSQWSDIEEFC----NRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRP 131
              + IC     WS     C      SCE P      S    +     F VG+VV++ C+ 
Sbjct: 3159 --TRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTF----GFQVGSVVQFHCKK 3212

Query: 132  GYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQI---DVPGGILFGATISF 188
            G+  + S +   TCL +L WS     C   SC  P    +  +   D+P     G T+ +
Sbjct: 3213 GHLLQGSTTR--TCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPS---HGYTLIY 3267

Query: 189  SCNTGYKLFGSTSSFCLISGSSVQWSDPLPEC 220
            +C  G+ L G T     +  S   W+  +P C
Sbjct: 3268 TCQPGFFLAGGTEH--RVCRSDNTWTGKVPIC 3297



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 73/275 (26%), Positives = 112/275 (40%), Gaps = 32/275 (11%)

Query: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESF-VKIPGEKDSVICLKGSQWS-DIEEF 93
            C  PP + N +  LEG T+F     I+Y C   + +  P     + C+    WS ++ + 
Sbjct: 3064 CPTPPQISNGR--LEG-TNFDWGFSISYICSPGYELSFPAV---LTCVGNGTWSGEVPQC 3117

Query: 94   CNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWST 153
              + C  P         Q       F   + V + C   +    S +    C  +  WS 
Sbjct: 3118 LPKFCGDP-----GIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTR--ICQADGTWSG 3170

Query: 154  AVEFC---KKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSS 210
            +   C    + SC NPG  R+G  +   G   G+ + F C  G+ L GST+  CL     
Sbjct: 3171 SSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCL---PD 3227

Query: 211  VQWSDPLPECREIYCPAPPQIDNGIIQG-ERDHYGYRQSVTYACNKGFTMIG--EHSIYC 267
            + WS   PEC    C  P    +  + G +   +GY  ++ Y C  GF + G  EH + C
Sbjct: 3228 LTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGY--TLIYTCQPGFFLAGGTEHRV-C 3284

Query: 268  TVNNDEGEWSGPPPECR-GKSLTSKVP-PTVQKPT 300
              +N    W+G  P C  G  +  K P P +  P+
Sbjct: 3285 RSDN---TWTGKVPICEAGSKILVKDPRPALGTPS 3316



 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 34/85 (40%), Positives = 42/85 (49%), Gaps = 5/85 (5%)

Query: 161  KSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPEC 220
            +SCP+P   RNG + +      G TISF C  GY L G+++  CL  G S  W+ PLP C
Sbjct: 2118 QSCPDPRPFRNGFV-IGNDFTVGQTISFECFPGYTLIGNSALTCL-HGVSRNWNHPLPRC 2175

Query: 221  REIYCPAPPQIDNGII--QGERDHY 243
             E  C       NG I   G  D Y
Sbjct: 2176 -EALCGGNITAMNGTIYSPGYPDEY 2199



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 30/75 (40%), Positives = 42/75 (56%), Gaps = 5/75 (6%)

Query: 163  CPNPGEIRNG-QIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECR 221
            C +PG  + G +I    GI  G T++FSC++GY+L G++   CL  G  V WS PLP C 
Sbjct: 1078 CEDPGIPQYGSRIGFNFGI--GDTLTFSCSSGYRLEGTSEIICLGGGRRV-WSAPLPRC- 1133

Query: 222  EIYCPAPPQIDNGII 236
               C A    + GI+
Sbjct: 1134 VAECGASATNNEGIL 1148



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 54/224 (24%), Positives = 77/224 (34%), Gaps = 56/224 (25%)

Query: 113  YITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLK--WSTAVEFCKKKSCPNPGEIR 170
            ++  N F VG  + +EC PGY    + +  LTCL  +   W+  +  C+   C       
Sbjct: 2130 FVIGNDFTVGQTISFECFPGYTLIGNSA--LTCLHGVSRNWNHPLPRCEAL-CGGNITAM 2186

Query: 171  NGQIDVPG---------------------GILFGATI----------------------- 186
            NG I  PG                     GI    T+                       
Sbjct: 2187 NGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPDQNSPQI 2246

Query: 187  -SFSCNTGYKLFGSTSSFCLIS-GSSVQWSDPLPECREIY----CPAPPQIDNGIIQGER 240
              FS NT  +   STS+  LI   S    S         Y    C  PP + N  I  E 
Sbjct: 2247 GQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQLRVCQPPPPVPNAEILTED 2306

Query: 241  DHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECR 284
            D +     + Y C  GFT++G   + C +  +  +  G PP C+
Sbjct: 2307 DEFEIGDIIRYQCLPGFTLVGNAILTCRL-GERLQMDGAPPVCQ 2349



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 26/73 (35%), Positives = 37/73 (50%), Gaps = 2/73 (2%)

Query: 163 CPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFC-LISGSSVQWSDPLPECR 221
           CP+PGE  NG+  +      G+T+ FSC+  Y L G+ S  C  I+     WSD  P C+
Sbjct: 382 CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 440

Query: 222 EIYCPAPPQIDNG 234
              C +  Q  +G
Sbjct: 441 VKTCGSNLQGPSG 453



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 22/58 (37%), Positives = 29/58 (50%), Gaps = 1/58 (1%)

Query: 163  CPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPEC 220
            C +PG  + G      G   G+TI + CN GY L GS+   C+ +G    W  PLP C
Sbjct: 1250 CEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCM-TGERRAWDYPLPSC 1306



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 30/89 (33%), Positives = 40/89 (44%), Gaps = 15/89 (16%)

Query: 156 EFCKKKSCPNPGEIRNGQIDVPGGILFGAT------ISFSCNTGYKLFGSTSSFCLI-SG 208
           E  +  SC NPG         P G+L+G        I +SC TGY L G     C+  S 
Sbjct: 171 EELQSSSCGNPGV-------PPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSV 223

Query: 209 SSVQWSDPLPECR-EIYCPAPPQIDNGII 236
           ++  W  P+P CR E  C    +  +GII
Sbjct: 224 NTASWDFPVPICRAEDACGGTMRGSSGII 252



 Score = 38.9 bits (89), Expect = 0.008
 Identities = 23/68 (33%), Positives = 32/68 (47%), Gaps = 2/68 (2%)

Query: 154  AVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFC-LISGSSVQ 212
            AV       C +  E R G+  +      G+++ F CN GY L GS +  C  +  S  Q
Sbjct: 1765 AVPRTSSTQCSSVPEPRFGR-RIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQ 1823

Query: 213  WSDPLPEC 220
            W+D LP C
Sbjct: 1824 WNDSLPTC 1831



 Score = 38.1 bits (87), Expect = 0.013
 Identities = 20/59 (33%), Positives = 30/59 (50%), Gaps = 2/59 (3%)

Query: 162  SCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPEC 220
            SCP P    +G I +    + G  +SF C+ GY L G +   C+  G   +W+ P+P C
Sbjct: 1947 SCPEPQTPSSG-IKIGDRYMVGDVVSFQCDQGYSLQGHSHITCM-PGPVRRWNYPIPIC 2003



 Score = 37.7 bits (86), Expect = 0.017
 Identities = 18/59 (30%), Positives = 30/59 (50%), Gaps = 3/59 (5%)

Query: 225  CPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPEC 283
            CP P    NG + G     G  Q++++ C  G+T+IG  ++ C ++     W+ P P C
Sbjct: 2120 CPDPRPFRNGFVIGNDFTVG--QTISFECFPGYTLIGNSALTC-LHGVSRNWNHPLPRC 2175



 Score = 37.0 bits (84), Expect = 0.030
 Identities = 23/63 (36%), Positives = 30/63 (47%), Gaps = 5/63 (7%)

Query: 239 ERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPP--TV 296
           E D +  R  + + C  GF +IGE SI C  NN   +WS   P C    L++   P  TV
Sbjct: 572 EGDGFSNRDVLRFECQFGFELIGEKSIVCQENN---QWSANIPICIFPCLSNFTAPMGTV 628

Query: 297 QKP 299
             P
Sbjct: 629 LSP 631



 Score = 36.6 bits (83), Expect = 0.039
 Identities = 19/62 (30%), Positives = 33/62 (53%), Gaps = 2/62 (3%)

Query: 160  KKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSS-VQWSDPLP 218
            ++SC +PG I NG   +      G+T+++ C+ GY L G ++  C++       W+  LP
Sbjct: 1594 RESCFDPGNIMNGT-RLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1652

Query: 219  EC 220
             C
Sbjct: 1653 SC 1654



 Score = 35.8 bits (81), Expect = 0.066
 Identities = 21/59 (35%), Positives = 30/59 (50%), Gaps = 4/59 (6%)

Query: 162 SCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPEC 220
           SC +PG   +G+         G+T+SFSC++GY+L       C     +  WS PLP C
Sbjct: 905 SCLDPGIPVHGR-RYGHDFSIGSTVSFSCDSGYRLSHEEPLLC---EKNHWWSHPLPTC 959



 Score = 35.4 bits (80), Expect = 0.086
 Identities = 39/152 (25%), Positives = 59/152 (38%), Gaps = 20/152 (13%)

Query: 217  LPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYC-TVNNDEGE 275
            +P      C + P+   G   G  + +    SV + CN G+ + G  +I C TV N   +
Sbjct: 1766 VPRTSSTQCSSVPEPRFGRRIG--NEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQ 1823

Query: 276  WSGPPPEC---RGKSLTSKVPPTVQKPTTVNVPTTEVSPTSQKTTTKTTTPNAQATRSTP 332
            W+   P C    G  LT +      K T ++    E    +     K T P     +   
Sbjct: 1824 WNDSLPTCIVPCGGILTKR------KGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQV 1877

Query: 333  VSRTTKH------FHETTPNKGS--GTTSGTT 356
            VS  T+H      F++   N     G+ SGTT
Sbjct: 1878 VSFATEHNWDSLDFYDGGDNNAPRLGSYSGTT 1909



 Score = 33.9 bits (76), Expect = 0.25
 Identities = 27/106 (25%), Positives = 43/106 (40%), Gaps = 7/106 (6%)

Query: 178  GGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQ 237
            G  + G T+S + N  +  F S +         V  S  L  C +   P  PQ    I  
Sbjct: 1208 GASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCED---PGIPQFGYKI-- 1262

Query: 238  GERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPEC 283
             ++ H+    ++ Y CN G+T+ G   + C +  +   W  P P C
Sbjct: 1263 SDQGHFA-GSTIIYGCNPGYTLHGSSLLKC-MTGERRAWDYPLPSC 1306



 Score = 33.5 bits (75), Expect = 0.33
 Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 2/59 (3%)

Query: 163 CPNPGEIRNGQIDVPGGILFGATISFSCNTGY-KLFGSTSSFCLISGSSVQWSDPLPEC 220
           CP+PG   N +         G++IS  C  G+ K  G+ +  C++    V WS  +P+C
Sbjct: 730 CPDPGIPINAR-RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 787



 Score = 32.7 bits (73), Expect = 0.56
 Identities = 23/78 (29%), Positives = 35/78 (44%), Gaps = 8/78 (10%)

Query: 207  SGSSVQWSDPLPE-CREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSI 265
            SG ++Q+S  +   CR+   P  P   NG   G+    G   +V + C+ G+ + GE  I
Sbjct: 1410 SGFAIQFSSSVATACRD---PGVPM--NGTRNGDGREPG--DTVVFQCDPGYELQGEERI 1462

Query: 266  YCTVNNDEGEWSGPPPEC 283
             C    +   W   PP C
Sbjct: 1463 TCIQVENRYFWQPSPPVC 1480



 Score = 32.3 bits (72), Expect = 0.73
 Identities = 31/122 (25%), Positives = 53/122 (43%), Gaps = 19/122 (15%)

Query: 171  NGQIDVPGGILFGATISFSCNTGYKLFGS-------TSSFCL-ISGSSVQWSD-PLPECR 221
            NG    P   L G+ +  + N G  L+G+        S F +   G ++ +S+  L  C 
Sbjct: 1022 NGSFTQPLARLTGSDLPPTINAG--LYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCE 1079

Query: 222  EIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPP 281
            +   P  PQ  + I      ++G   ++T++C+ G+ + G   I C +      WS P P
Sbjct: 1080 D---PGIPQYGSRI----GFNFGIGDTLTFSCSSGYRLEGTSEIIC-LGGGRRVWSAPLP 1131

Query: 282  EC 283
             C
Sbjct: 1132 RC 1133



 Score = 32.0 bits (71), Expect = 0.95
 Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 3/59 (5%)

Query: 225  CPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPEC 283
            CP P    +GI  G+R  Y     V++ C++G+++ G   I C +      W+ P P C
Sbjct: 1948 CPEPQTPSSGIKIGDR--YMVGDVVSFQCDQGYSLQGHSHITC-MPGPVRRWNYPIPIC 2003



 Score = 30.4 bits (67), Expect = 2.8
 Identities = 18/59 (30%), Positives = 26/59 (44%), Gaps = 1/59 (1%)

Query: 162  SCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPEC 220
            +C +PG   NG  +  G    G T+ F C+ GY+L G     C+   +   W    P C
Sbjct: 1423 ACRDPGVPMNGTRNGDGREP-GDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1480


>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
          Length = 3707

 Score =  108 bits (269), Expect = 1e-23
 Identities = 81/256 (31%), Positives = 111/256 (43%), Gaps = 24/256 (9%)

Query: 34   GDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEF 93
            G CG+P  + N Q  + G      DTV+ Y+C   F  I       IC +   WS     
Sbjct: 2815 GHCGIPELIVNGQ--VIGENYGYRDTVV-YQCNPGFRLIGSSVR--ICQQDHNWSGQLPS 2869

Query: 94   CNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWS 152
            C   SC  P      S      + N F    VV + C  GY  +     K  C  N +WS
Sbjct: 2870 CVPVSCGHP-----GSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPT--KAQCQANRQWS 2922

Query: 153  TAVEFCKKKSCPNPGEIRNGQIDVP---GGILFGATISFSCNTGYKLFGSTSSFCLISGS 209
                 CK  +C +PG   N + +     G   +G  + + CN GY LFGS+   C  +G 
Sbjct: 2923 HPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNG- 2981

Query: 210  SVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTV 269
              QW  PLPEC  I C  P    N ++ GE+  Y +  +V Y+C    +++G+ S  C +
Sbjct: 2982 --QWDKPLPECIMIDCGHPGVPPNAVLSGEK--YTFGSTVHYSCTGKRSLLGQSSRTCQL 3037

Query: 270  NNDEGEWSGPPPECRG 285
            N   G WSG  P C G
Sbjct: 3038 N---GHWSGSQPHCSG 3050



 Score =  105 bits (261), Expect = 9e-23
 Identities = 87/288 (30%), Positives = 120/288 (41%), Gaps = 38/288 (13%)

Query: 25   VLLCLP----------AVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPG 74
            VL+C P           +  DCG P   PNA   L G   +   + + Y C      +  
Sbjct: 2974 VLICQPNGQWDKPLPECIMIDCGHPGVPPNA--VLSGE-KYTFGSTVHYSCTGKRSLLG- 3029

Query: 75   EKDSVICLKGSQWSDIEEFCNR----SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECR 130
             + S  C     WS  +  C+     +C  P      S ++     + F   + V Y C 
Sbjct: 3030 -QSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQE-----SNFRTKSTVRYACD 3083

Query: 131  PGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSC 190
             GY    S   + TCL N  W+     CK   C NPG   NG++    G  F +++ +SC
Sbjct: 3084 TGYILHGS--EERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSC 3141

Query: 191  NTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVT 250
              GY L G +   C  +G+   WS  LP C  I C  P    NG+  G  D Y   Q+V+
Sbjct: 3142 MEGYILSGPSVRQCTANGT---WSGTLPNCTIISCGDPGIPANGLRYG--DDYVVGQNVS 3196

Query: 251  YACNKGFTM--IGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTV 296
            Y C  G+TM   G     CT+N   G WSG  P CR  ++T   PP +
Sbjct: 3197 YMCQPGYTMELNGSRIRTCTIN---GTWSGVMPTCR--AVTCPTPPQI 3239



 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 78/256 (30%), Positives = 110/256 (42%), Gaps = 25/256 (9%)

Query: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCN 95
            CG+P    N        T +   T +TY C + +     E  + +C     WS+  +   
Sbjct: 2632 CGIPKAPTNGGILT---TDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNK--T 2686

Query: 96   RSCEVPT--RLNSASLKQP---YITQNYFPVGTVVEYECRPGYRREPSLSP-KLTCLQNL 149
              C V T   +NS  L+      +  +++   T V + C PGY     L P  + CL N 
Sbjct: 2687 PRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYH---GLGPASIECLPNG 2743

Query: 150  KWSTAVE--FCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLIS 207
             WS   E  +C+  SC       NG   +     +G+T  F+C+ G+ L GS    CL S
Sbjct: 2744 TWSWRNERPYCQIISCGELPTPPNGN-KIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSS 2802

Query: 208  GSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYC 267
            G    WS+    C   +C  P  I NG + GE  +YGYR +V Y CN GF +IG     C
Sbjct: 2803 GL---WSESETRCLAGHCGIPELIVNGQVIGE--NYGYRDTVVYQCNPGFRLIGSSVRIC 2857

Query: 268  TVNNDEGEWSGPPPEC 283
                 +  WSG  P C
Sbjct: 2858 ---QQDHNWSGQLPSC 2870



 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 79/274 (28%), Positives = 120/274 (43%), Gaps = 29/274 (10%)

Query: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKI-PGEKDSVICLKGSQWSDIEEFC 94
            CG P    N +      T+F    +  Y C E ++   P  +    C     WS     C
Sbjct: 3114 CGNPGTTANGKVFRIDGTTFSSSVI--YSCMEGYILSGPSVRQ---CTANGTWSGTLPNC 3168

Query: 95   NR-SCEVP-TRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWS 152
               SC  P    N       Y+      VG  V Y C+PGY  E + S   TC  N  WS
Sbjct: 3169 TIISCGDPGIPANGLRYGDDYV------VGQNVSYMCQPGYTMELNGSRIRTCTINGTWS 3222

Query: 153  TAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQ 212
              +  C+  +CP P +I NG+++      +G +IS+ C+ GY+L       C+ +G+   
Sbjct: 3223 GVMPTCRAVTCPTPPQISNGRLE-GTNFDWGFSISYICSPGYELSFPAVLTCVGNGT--- 3278

Query: 213  WSDPLPECREIYCPAPPQIDNGI-IQGERD--HYGYRQSVTYACNKGFTMIGEHSIYCTV 269
            WS  +P+C   +C  P     GI  QG+R+   + Y+  V+++CN  F ++G  +  C  
Sbjct: 3279 WSGEVPQCLPKFCGDP-----GIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQA 3333

Query: 270  NNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVN 303
               +G WSG  P C   + TS   P V +  + N
Sbjct: 3334 ---DGTWSGSSPHCIEPTQTSCENPGVPRHGSQN 3364



 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 59/212 (27%), Positives = 89/212 (41%), Gaps = 33/212 (15%)

Query: 16   GELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGE 75
            GE+P+       CLP   GD G+P     AQ   EG+ SF   + +++ C   F+ +   
Sbjct: 3281 GEVPQ-------CLPKFCGDPGIP-----AQGKREGK-SFIYQSEVSFSCNFPFILVGSS 3327

Query: 76   KDSVICLKGSQWSDIEEFC----NRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRP 131
              + IC     WS     C      SCE P      S    +     F VG+VV++ C+ 
Sbjct: 3328 --TRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTF----GFQVGSVVQFHCKK 3381

Query: 132  GYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQI---DVPGGILFGATISF 188
            G+  + S +   TCL +L WS     C   SC  P    +  +   D+P     G T+ +
Sbjct: 3382 GHLLQGSTTR--TCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPS---HGYTLIY 3436

Query: 189  SCNTGYKLFGSTSSFCLISGSSVQWSDPLPEC 220
            +C  G+ L G T     +  S   W+  +P C
Sbjct: 3437 TCQPGFFLAGGTEH--RVCRSDNTWTGKVPIC 3466



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 73/275 (26%), Positives = 112/275 (40%), Gaps = 32/275 (11%)

Query: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESF-VKIPGEKDSVICLKGSQWS-DIEEF 93
            C  PP + N +  LEG T+F     I+Y C   + +  P     + C+    WS ++ + 
Sbjct: 3233 CPTPPQISNGR--LEG-TNFDWGFSISYICSPGYELSFPAV---LTCVGNGTWSGEVPQC 3286

Query: 94   CNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWST 153
              + C  P         Q       F   + V + C   +    S +    C  +  WS 
Sbjct: 3287 LPKFCGDP-----GIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTR--ICQADGTWSG 3339

Query: 154  AVEFC---KKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSS 210
            +   C    + SC NPG  R+G  +   G   G+ + F C  G+ L GST+  CL     
Sbjct: 3340 SSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCL---PD 3396

Query: 211  VQWSDPLPECREIYCPAPPQIDNGIIQG-ERDHYGYRQSVTYACNKGFTMIG--EHSIYC 267
            + WS   PEC    C  P    +  + G +   +GY  ++ Y C  GF + G  EH + C
Sbjct: 3397 LTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGY--TLIYTCQPGFFLAGGTEHRV-C 3453

Query: 268  TVNNDEGEWSGPPPECR-GKSLTSKVP-PTVQKPT 300
              +N    W+G  P C  G  +  K P P +  P+
Sbjct: 3454 RSDN---TWTGKVPICEAGSKILVKDPRPALGTPS 3485



 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 34/85 (40%), Positives = 42/85 (49%), Gaps = 5/85 (5%)

Query: 161  KSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPEC 220
            +SCP+P   RNG + +      G TISF C  GY L G+++  CL  G S  W+ PLP C
Sbjct: 2222 QSCPDPRPFRNGFV-IGNDFTVGQTISFECFPGYTLIGNSALTCL-HGVSRNWNHPLPRC 2279

Query: 221  REIYCPAPPQIDNGII--QGERDHY 243
             E  C       NG I   G  D Y
Sbjct: 2280 -EALCGGNITAMNGTIYSPGYPDEY 2303



 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 36/124 (29%), Positives = 52/124 (41%), Gaps = 6/124 (4%)

Query: 163  CPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQ-WSDPLPECR 221
            C  P    +G I    G    + + ++C+ G++L G +S+ C  S      W  P+P C+
Sbjct: 2569 CSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2628

Query: 222  EIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWS--GP 279
             I C  P    NG I       G R  VTY CN G+  +    +   V   +G WS    
Sbjct: 2629 AISCGIPKAPTNGGILTTDYLVGTR--VTYFCNDGY-RLSSKELTTAVCQSDGTWSNHNK 2685

Query: 280  PPEC 283
             P C
Sbjct: 2686 TPRC 2689



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 30/75 (40%), Positives = 42/75 (56%), Gaps = 5/75 (6%)

Query: 163  CPNPGEIRNG-QIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECR 221
            C +PG  + G +I    GI  G T++FSC++GY+L G++   CL  G  V WS PLP C 
Sbjct: 1182 CEDPGIPQYGSRIGFNFGI--GDTLTFSCSSGYRLEGTSEIICLGGGRRV-WSAPLPRC- 1237

Query: 222  EIYCPAPPQIDNGII 236
               C A    + GI+
Sbjct: 1238 VAECGASATNNEGIL 1252



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 54/224 (24%), Positives = 77/224 (34%), Gaps = 56/224 (25%)

Query: 113  YITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLK--WSTAVEFCKKKSCPNPGEIR 170
            ++  N F VG  + +EC PGY    + +  LTCL  +   W+  +  C+   C       
Sbjct: 2234 FVIGNDFTVGQTISFECFPGYTLIGNSA--LTCLHGVSRNWNHPLPRCEAL-CGGNITAM 2290

Query: 171  NGQIDVPG---------------------GILFGATI----------------------- 186
            NG I  PG                     GI    T+                       
Sbjct: 2291 NGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPDQNSPQI 2350

Query: 187  -SFSCNTGYKLFGSTSSFCLIS-GSSVQWSDPLPECREIY----CPAPPQIDNGIIQGER 240
              FS NT  +   STS+  LI   S    S         Y    C  PP + N  I  E 
Sbjct: 2351 GQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQLRVCQPPPPVPNAEILTED 2410

Query: 241  DHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECR 284
            D +     + Y C  GFT++G   + C +  +  +  G PP C+
Sbjct: 2411 DEFEIGDIIRYQCLPGFTLVGNAILTCRL-GERLQMDGAPPVCQ 2453



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 26/73 (35%), Positives = 37/73 (50%), Gaps = 2/73 (2%)

Query: 163 CPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFC-LISGSSVQWSDPLPECR 221
           CP+PGE  NG+  +      G+T+ FSC+  Y L G+ S  C  I+     WSD  P C+
Sbjct: 486 CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 544

Query: 222 EIYCPAPPQIDNG 234
              C +  Q  +G
Sbjct: 545 VKTCGSNLQGPSG 557



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 22/58 (37%), Positives = 29/58 (50%), Gaps = 1/58 (1%)

Query: 163  CPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPEC 220
            C +PG  + G      G   G+TI + CN GY L GS+   C+ +G    W  PLP C
Sbjct: 1354 CEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCM-TGERRAWDYPLPSC 1410



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 30/89 (33%), Positives = 40/89 (44%), Gaps = 15/89 (16%)

Query: 156 EFCKKKSCPNPGEIRNGQIDVPGGILFGAT------ISFSCNTGYKLFGSTSSFCLI-SG 208
           E  +  SC NPG         P G+L+G        I +SC TGY L G     C+  S 
Sbjct: 171 EELQSSSCGNPGV-------PPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSV 223

Query: 209 SSVQWSDPLPECR-EIYCPAPPQIDNGII 236
           ++  W  P+P CR E  C    +  +GII
Sbjct: 224 NTASWDFPVPICRAEDACGGTMRGSSGII 252



 Score = 38.9 bits (89), Expect = 0.008
 Identities = 23/68 (33%), Positives = 32/68 (47%), Gaps = 2/68 (2%)

Query: 154  AVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFC-LISGSSVQ 212
            AV       C +  E R G+  +      G+++ F CN GY L GS +  C  +  S  Q
Sbjct: 1869 AVPRTSSTQCSSVPEPRFGR-RIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQ 1927

Query: 213  WSDPLPEC 220
            W+D LP C
Sbjct: 1928 WNDSLPTC 1935



 Score = 38.1 bits (87), Expect = 0.013
 Identities = 20/59 (33%), Positives = 30/59 (50%), Gaps = 2/59 (3%)

Query: 162  SCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPEC 220
            SCP P    +G I +    + G  +SF C+ GY L G +   C+  G   +W+ P+P C
Sbjct: 2051 SCPEPQTPSSG-IKIGDRYMVGDVVSFQCDQGYSLQGHSHITCM-PGPVRRWNYPIPIC 2107



 Score = 37.7 bits (86), Expect = 0.017
 Identities = 18/59 (30%), Positives = 30/59 (50%), Gaps = 3/59 (5%)

Query: 225  CPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPEC 283
            CP P    NG + G     G  Q++++ C  G+T+IG  ++ C ++     W+ P P C
Sbjct: 2224 CPDPRPFRNGFVIGNDFTVG--QTISFECFPGYTLIGNSALTC-LHGVSRNWNHPLPRC 2279



 Score = 37.0 bits (84), Expect = 0.030
 Identities = 23/63 (36%), Positives = 30/63 (47%), Gaps = 5/63 (7%)

Query: 239 ERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPP--TV 296
           E D +  R  + + C  GF +IGE SI C  NN   +WS   P C    L++   P  TV
Sbjct: 676 EGDGFSNRDVLRFECQFGFELIGEKSIVCQENN---QWSANIPICIFPCLSNFTAPMGTV 732

Query: 297 QKP 299
             P
Sbjct: 733 LSP 735



 Score = 36.6 bits (83), Expect = 0.039
 Identities = 19/62 (30%), Positives = 33/62 (53%), Gaps = 2/62 (3%)

Query: 160  KKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSS-VQWSDPLP 218
            ++SC +PG I NG   +      G+T+++ C+ GY L G ++  C++       W+  LP
Sbjct: 1698 RESCFDPGNIMNGT-RLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1756

Query: 219  EC 220
             C
Sbjct: 1757 SC 1758



 Score = 35.8 bits (81), Expect = 0.066
 Identities = 21/59 (35%), Positives = 30/59 (50%), Gaps = 4/59 (6%)

Query: 162  SCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPEC 220
            SC +PG   +G+         G+T+SFSC++GY+L       C     +  WS PLP C
Sbjct: 1009 SCLDPGIPVHGR-RYGHDFSIGSTVSFSCDSGYRLSHEEPLLC---EKNHWWSHPLPTC 1063



 Score = 35.4 bits (80), Expect = 0.086
 Identities = 39/152 (25%), Positives = 59/152 (38%), Gaps = 20/152 (13%)

Query: 217  LPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYC-TVNNDEGE 275
            +P      C + P+   G   G  + +    SV + CN G+ + G  +I C TV N   +
Sbjct: 1870 VPRTSSTQCSSVPEPRFGRRIG--NEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQ 1927

Query: 276  WSGPPPEC---RGKSLTSKVPPTVQKPTTVNVPTTEVSPTSQKTTTKTTTPNAQATRSTP 332
            W+   P C    G  LT +      K T ++    E    +     K T P     +   
Sbjct: 1928 WNDSLPTCIVPCGGILTKR------KGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQV 1981

Query: 333  VSRTTKH------FHETTPNKGS--GTTSGTT 356
            VS  T+H      F++   N     G+ SGTT
Sbjct: 1982 VSFATEHNWDSLDFYDGGDNNAPRLGSYSGTT 2013



 Score = 33.9 bits (76), Expect = 0.25
 Identities = 27/106 (25%), Positives = 43/106 (40%), Gaps = 7/106 (6%)

Query: 178  GGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQ 237
            G  + G T+S + N  +  F S +         V  S  L  C +   P  PQ    I  
Sbjct: 1312 GASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCED---PGIPQFGYKI-- 1366

Query: 238  GERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPEC 283
             ++ H+    ++ Y CN G+T+ G   + C +  +   W  P P C
Sbjct: 1367 SDQGHFA-GSTIIYGCNPGYTLHGSSLLKC-MTGERRAWDYPLPSC 1410



 Score = 33.5 bits (75), Expect = 0.33
 Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 2/59 (3%)

Query: 163 CPNPGEIRNGQIDVPGGILFGATISFSCNTGY-KLFGSTSSFCLISGSSVQWSDPLPEC 220
           CP+PG   N +         G++IS  C  G+ K  G+ +  C++    V WS  +P+C
Sbjct: 834 CPDPGIPINAR-RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 891



 Score = 32.7 bits (73), Expect = 0.56
 Identities = 23/78 (29%), Positives = 35/78 (44%), Gaps = 8/78 (10%)

Query: 207  SGSSVQWSDPLPE-CREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSI 265
            SG ++Q+S  +   CR+   P  P   NG   G+    G   +V + C+ G+ + GE  I
Sbjct: 1514 SGFAIQFSSSVATACRD---PGVPM--NGTRNGDGREPG--DTVVFQCDPGYELQGEERI 1566

Query: 266  YCTVNNDEGEWSGPPPEC 283
             C    +   W   PP C
Sbjct: 1567 TCIQVENRYFWQPSPPVC 1584



 Score = 32.3 bits (72), Expect = 0.73
 Identities = 31/122 (25%), Positives = 53/122 (43%), Gaps = 19/122 (15%)

Query: 171  NGQIDVPGGILFGATISFSCNTGYKLFGS-------TSSFCL-ISGSSVQWSD-PLPECR 221
            NG    P   L G+ +  + N G  L+G+        S F +   G ++ +S+  L  C 
Sbjct: 1126 NGSFTQPLARLTGSDLPPTINAG--LYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCE 1183

Query: 222  EIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPP 281
            +   P  PQ  + I      ++G   ++T++C+ G+ + G   I C +      WS P P
Sbjct: 1184 D---PGIPQYGSRI----GFNFGIGDTLTFSCSSGYRLEGTSEIIC-LGGGRRVWSAPLP 1235

Query: 282  EC 283
             C
Sbjct: 1236 RC 1237



 Score = 32.0 bits (71), Expect = 0.95
 Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 3/59 (5%)

Query: 225  CPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPEC 283
            CP P    +GI  G+R  Y     V++ C++G+++ G   I C +      W+ P P C
Sbjct: 2052 CPEPQTPSSGIKIGDR--YMVGDVVSFQCDQGYSLQGHSHITC-MPGPVRRWNYPIPIC 2107



 Score = 30.4 bits (67), Expect = 2.8
 Identities = 18/59 (30%), Positives = 26/59 (44%), Gaps = 1/59 (1%)

Query: 162  SCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPEC 220
            +C +PG   NG  +  G    G T+ F C+ GY+L G     C+   +   W    P C
Sbjct: 1527 ACRDPGVPMNGTRNGDGREP-GDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1584


>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
          Length = 3565

 Score =  107 bits (267), Expect = 2e-23
 Identities = 84/280 (30%), Positives = 125/280 (44%), Gaps = 33/280 (11%)

Query: 28   CLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQW 87
            CL    G  G+P     A   L G   F    V+ Y C  S   I    D+ +C + S W
Sbjct: 2855 CLAISCGHPGVP-----ANAVLTGEL-FTYGAVVHYSCRGSESLIGN--DTRVCQEDSHW 2906

Query: 88   SDIEEFCNRS----CEVP-TRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPK 142
            S     C  +    C  P T  + + L   + T++      ++ + C  G++   S  P+
Sbjct: 2907 SGALPHCTGNNPGFCGDPGTPAHGSRLGDDFKTKS------LLRFSCEMGHQLRGS--PE 2958

Query: 143  LTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSS 202
             TCL N  WS     C+  SC NPG   NG I    GILF +++ ++C  GYK  G  + 
Sbjct: 2959 RTCLLNGSWSGLQPVCEAVSCGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTR 3018

Query: 203  FCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTM--I 260
             C  +G+   W+   P+C  I C  P  + NGI  G    + + ++V+Y CN G+ M  +
Sbjct: 3019 HCTANGT---WTGTAPDCTIISCGDPGTLANGIQFG--TDFTFNKTVSYQCNPGYVMEAV 3073

Query: 261  GEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPT 300
               +I CT    +G W+   P C  K++    PP VQ  T
Sbjct: 3074 TSATIRCT---KDGRWNPSKPVC--KAVLCPQPPPVQNGT 3108



 Score =  101 bits (252), Expect = 1e-21
 Identities = 67/209 (32%), Positives = 100/209 (47%), Gaps = 22/209 (10%)

Query: 81   CLKGSQWSDIEEFCNRS-CEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSL 139
            CL    WS  E  C    C  P  + +      +I+ + F     V Y+C PG+R   + 
Sbjct: 2663 CLANGLWSGSETRCLAGHCGSPDPIVNG-----HISGDGFSYRDTVVYQCNPGFRLVGT- 2716

Query: 140  SPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGAT--ISFSCNTGYKLF 197
            S ++ CLQ+ KWS     C   +C +PG   +G      G  F     ++F+CNTGY L 
Sbjct: 2717 SVRI-CLQDHKWSGQTPVCVPITCGHPGNPAHG---FTNGSEFNLNDVVNFTCNTGYLLQ 2772

Query: 198  GSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGER---DHYGYRQSVTYACN 254
            G + + C  +G   QWS PLP CR + C  P  ++N I  G++   + + Y  S+ Y C 
Sbjct: 2773 GVSRAQCRSNG---QWSSPLPTCRVVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCK 2829

Query: 255  KGFTMIGEHSIYCTVNNDEGEWSGPPPEC 283
            KGF ++G  ++ C  N   G W    P+C
Sbjct: 2830 KGFYLLGSSALTCMAN---GLWDRSLPKC 2855



 Score = 99.8 bits (247), Expect = 4e-21
 Identities = 74/259 (28%), Positives = 118/259 (45%), Gaps = 25/259 (9%)

Query: 34   GDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEF 93
            G CG P  + N   + +G +    DTV+ Y+C   F ++ G     ICL+  +WS     
Sbjct: 2679 GHCGSPDPIVNGHISGDGFSY--RDTVV-YQCNPGF-RLVGTSVR-ICLQDHKWSGQTPV 2733

Query: 94   CNRSCEVP-TRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWS 152
            C     VP T  +  +    +   + F +  VV + C  GY  +     +  C  N +WS
Sbjct: 2734 C-----VPITCGHPGNPAHGFTNGSEFNLNDVVNFTCNTGYLLQGV--SRAQCRSNGQWS 2786

Query: 153  TAVEFCKKKSCPNPG----EIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISG 208
            + +  C+  +C +PG     IR+GQ + P    +G +I + C  G+ L GS++  C+ +G
Sbjct: 2787 SPLPTCRVVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANG 2846

Query: 209  SSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCT 268
                W   LP+C  I C  P    N ++ GE   YG    V Y+C    ++IG  +  C 
Sbjct: 2847 L---WDRSLPKCLAISCGHPGVPANAVLTGELFTYG--AVVHYSCRGSESLIGNDTRVC- 2900

Query: 269  VNNDEGEWSGPPPECRGKS 287
               ++  WSG  P C G +
Sbjct: 2901 --QEDSHWSGALPHCTGNN 2917



 Score = 93.2 bits (230), Expect = 3e-19
 Identities = 81/264 (30%), Positives = 109/264 (41%), Gaps = 41/264 (15%)

Query: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSD------ 89
            CG+P    N   +  G   F  D+ + Y+C E F     ++ + +C +   WS+      
Sbjct: 2496 CGIPESPGNG--SFTGN-EFTLDSKVVYECHEGFKLESSQQATAVCQEDGLWSNKGKPPT 2552

Query: 90   --------IEEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSP 141
                    IE     S  V  RL S SL +          G  V   C PGY  E     
Sbjct: 2553 CKPVACPSIE--AQLSEHVIWRLVSGSLNE---------YGAQVLLSCSPGYYLEGWRL- 2600

Query: 142  KLTCLQNLKWSTAVE--FCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGS 199
             L C  N  W+   E   C+  SC +     NG   +    ++GAT  F+CNTGY L GS
Sbjct: 2601 -LRCQANGTWNIGDERPSCRVISCGSLSFPPNGN-KIGTLTVYGATAIFTCNTGYTLVGS 2658

Query: 200  TSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTM 259
                CL +G    WS     C   +C +P  I NG I G  D + YR +V Y CN GF +
Sbjct: 2659 HVRECLANG---LWSGSETRCLAGHCGSPDPIVNGHISG--DGFSYRDTVVYQCNPGFRL 2713

Query: 260  IGEHSIYCTVNNDEGEWSGPPPEC 283
            +G     C     + +WSG  P C
Sbjct: 2714 VGTSVRICL---QDHKWSGQTPVC 2734



 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 49/165 (29%), Positives = 78/165 (47%), Gaps = 9/165 (5%)

Query: 119  FPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPG 178
            F     V Y+C PGY  E   S  + C ++ +W+ +   CK   CP P  ++NG ++   
Sbjct: 3054 FTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVE-GS 3112

Query: 179  GILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQG 238
               +G++IS+SC  GY+L  S S+     G  V W   +P+C  ++C  P     G + G
Sbjct: 3113 DFRWGSSISYSCMDGYQL--SHSAILSCEGRGV-WKGEIPQCLPVFCGDPGIPAEGRLSG 3169

Query: 239  ERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPEC 283
            +   + Y+  V + C   F ++G     C     +G WSG  P C
Sbjct: 3170 K--SFTYKSEVFFQCKSPFILVGSSRRVCQA---DGTWSGIQPTC 3209



 Score = 68.9 bits (167), Expect = 7e-12
 Identities = 62/251 (24%), Positives = 105/251 (41%), Gaps = 39/251 (15%)

Query: 16   GELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGE 75
            GE+P+       CLP   GD G+P     A+  L G+ SF   + + ++C+  F+ +   
Sbjct: 3146 GEIPQ-------CLPVFCGDPGIP-----AEGRLSGK-SFTYKSEVFFQCKSPFILVGSS 3192

Query: 76   KDSVICLKGSQWSDIEEFC----NRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRP 131
            +   +C     WS I+  C    + +C  P   +         +   + VG+ V + CR 
Sbjct: 3193 RR--VCQADGTWSGIQPTCIDPAHNTCPDPGTPHFGIQN----SSRGYEVGSTVFFRCRK 3246

Query: 132  GYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCN 191
            GY  + S +   TCL NL WS     C   +C  P    +  +       FG T+ ++C+
Sbjct: 3247 GYHIQGSTT--RTCLANLTWSGIQTECIPHACRQPETPAHADVRAIDLPTFGYTLVYTCH 3304

Query: 192  TGYKLFGSTSSFCLISGSSVQWSDPLPEC-----REI-----YCPAPPQI--DNGIIQGE 239
             G+ L G +        + ++W+   P C     RE+       P P  +   N + +G 
Sbjct: 3305 PGFFLAGGSEH--RTCKADMKWTGKSPVCKSKGVREVNETVTKTPVPSDVFFVNSLWKGY 3362

Query: 240  RDHYGYRQSVT 250
             ++ G RQ  T
Sbjct: 3363 YEYLGKRQPAT 3373



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 71/324 (21%), Positives = 118/324 (36%), Gaps = 77/324 (23%)

Query: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCN 95
            CG P  + N    ++  T F  +  ++Y+C   +V       ++ C K  +W+  +  C 
Sbjct: 3038 CGDPGTLANG---IQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCK 3094

Query: 96   RS-CEVPTRLNSASLKQPYITQNYFPVGTVVEYECR------------------------ 130
               C  P  + + +++      + F  G+ + Y C                         
Sbjct: 3095 AVLCPQPPPVQNGTVEG-----SDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIP 3149

Query: 131  ---------PGYRREPSLSPKL-----------------------TCLQNLKWSTAVEFC 158
                     PG   E  LS K                         C  +  WS     C
Sbjct: 3150 QCLPVFCGDPGIPAEGRLSGKSFTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPTC 3209

Query: 159  ---KKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSD 215
                  +CP+PG    G  +   G   G+T+ F C  GY + GST+  CL   +++ WS 
Sbjct: 3210 IDPAHNTCPDPGTPHFGIQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTCL---ANLTWSG 3266

Query: 216  PLPECREIYCPAPPQIDNGIIQG-ERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEG 274
               EC    C  P    +  ++  +   +GY  ++ Y C+ GF + G  S + T   D  
Sbjct: 3267 IQTECIPHACRQPETPAHADVRAIDLPTFGY--TLVYTCHPGFFLAG-GSEHRTCKADM- 3322

Query: 275  EWSGPPPECRGKSLTSKVPPTVQK 298
            +W+G  P C+ K +  +V  TV K
Sbjct: 3323 KWTGKSPVCKSKGV-REVNETVTK 3345



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 53/198 (26%), Positives = 81/198 (40%), Gaps = 23/198 (11%)

Query: 121  VGTVVEYECRPGYRREPSLSPKLTCLQN----LKWSTAVEFCKKKSCPNPGEIRNGQIDV 176
            VG+ V Y C+PGYR         TC +N     +W +    C+  SC  P    NG    
Sbjct: 2452 VGSKVHYFCKPGYRMVG--HSNATCRRNPLGMYQWDSLTPLCQAVSCGIPESPGNGSF-T 2508

Query: 177  PGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSD--PLPECREIYCPA-PPQIDN 233
                   + + + C+ G+KL  S  +  +     + WS+    P C+ + CP+   Q+  
Sbjct: 2509 GNEFTLDSKVVYECHEGFKLESSQQATAVCQEDGL-WSNKGKPPTCKPVACPSIEAQLSE 2567

Query: 234  GII----QGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWS--GPPPECRGKS 287
             +I     G  + YG    V  +C+ G+ + G   + C  N   G W+     P CR  S
Sbjct: 2568 HVIWRLVSGSLNEYG--AQVLLSCSPGYYLEGWRLLRCQAN---GTWNIGDERPSCRVIS 2622

Query: 288  LTS-KVPPTVQKPTTVNV 304
              S   PP   K  T+ V
Sbjct: 2623 CGSLSFPPNGNKIGTLTV 2640



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 37/129 (28%), Positives = 59/129 (45%), Gaps = 9/129 (6%)

Query: 154  AVEFCKK--KSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLI-SGSS 210
            A+EF +K  ++C +PG I NG   V      G+TI++ C++GYK+   +S  C+I +   
Sbjct: 1554 AIEFKEKPREACFDPGNIMNGT-RVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGK 1612

Query: 211  VQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYR--QSVTYACN--KGFTMIGEHSIY 266
              W   LP C    C        G++      + Y   Q   Y+    K F + G+ + +
Sbjct: 1613 PSWDQVLPSC-NAPCGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYF 1671

Query: 267  CTVNNDEGE 275
             T  ND  E
Sbjct: 1672 QTALNDLAE 1680



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 26/75 (34%), Positives = 36/75 (48%), Gaps = 1/75 (1%)

Query: 163 CPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCL-ISGSSVQWSDPLPECR 221
           CP+PG   NG+         GA + FSC   Y L GS S  C  ++ +   WSD  P CR
Sbjct: 349 CPDPGIPENGRRAGSDFSRVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICR 408

Query: 222 EIYCPAPPQIDNGII 236
              C +  +  +G+I
Sbjct: 409 ARTCGSNLRGPSGVI 423



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 26/69 (37%), Positives = 32/69 (46%), Gaps = 6/69 (8%)

Query: 156 EFCKKKSCPNPGEIRNGQIDVPGGILF--GATISFSCNTGYKLFGSTSSFCLIS-GSSVQ 212
           E     +C NPGEI  G +    G  F  G  I +SC  GY L G     C++S G+   
Sbjct: 138 EVLPSHTCGNPGEILKGVLH---GTRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGAS 194

Query: 213 WSDPLPECR 221
           W  P P CR
Sbjct: 195 WDFPAPFCR 203



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 25/78 (32%), Positives = 39/78 (50%), Gaps = 3/78 (3%)

Query: 160 KKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGY-KLFGSTSSFCLISGSSVQWSDPLP 218
           +  C +PG   NG+       L G+++SF C+ G+ K  GS S  C++   +V WS  +P
Sbjct: 695 QNECHDPGIPINGR-RFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVP 753

Query: 219 ECREIYCPAPPQIDNGII 236
            C E  C       +G+I
Sbjct: 754 RC-EAPCGGHLTASSGVI 770



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 19/38 (50%), Positives = 24/38 (63%), Gaps = 1/38 (2%)

Query: 183  GATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPEC 220
            G +++FSC  GY+L G+T   CL  G  V WS PLP C
Sbjct: 1065 GDSLTFSCFLGYRLEGATKLTCLGGGRRV-WSAPLPRC 1101



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 21/58 (36%), Positives = 26/58 (44%), Gaps = 1/58 (1%)

Query: 163  CPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPEC 220
            C +PG    G      G      + +SCN GY + GS +  CL SG    W  PLP C
Sbjct: 1218 CEDPGIPNYGYRIRDEGHFTDTVVLYSCNPGYAMHGSNTLTCL-SGDRRVWDKPLPSC 1274



 Score = 38.9 bits (89), Expect = 0.008
 Identities = 16/39 (41%), Positives = 23/39 (58%), Gaps = 1/39 (2%)

Query: 183  GATISFSCNTGYKLFGSTSSFC-LISGSSVQWSDPLPEC 220
            G+ + F CN GY L GST+  C  +  +  QW+D +P C
Sbjct: 1761 GSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSC 1799



 Score = 38.9 bits (89), Expect = 0.008
 Identities = 35/129 (27%), Positives = 50/129 (38%), Gaps = 17/129 (13%)

Query: 161  KSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPEC 220
            ++CP+P   +NG + +      G ++SF C  GY L G     C   G +  W+ P P C
Sbjct: 2086 QNCPDPPPFQNGYM-INSDYSVGQSVSFECYPGYILIGHPVLTCQ-HGINRNWNYPFPRC 2143

Query: 221  REIYCPAPPQIDNGII--QGERDHYGYRQSVTYACNKGFTMIGEHSIYC--------TVN 270
             +  C       NG I   G  D Y     +   C    T+   H +Y          VN
Sbjct: 2144 -DAPCGYNVTSQNGTIYSPGFPDEY----PILKDCIWLITVPPGHGVYINFTLLQTEAVN 2198

Query: 271  NDEGEWSGP 279
            +    W GP
Sbjct: 2199 DYIAVWDGP 2207



 Score = 38.5 bits (88), Expect = 0.010
 Identities = 23/77 (29%), Positives = 34/77 (44%), Gaps = 6/77 (7%)

Query: 207  SGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIY 266
            SG S+Q+S  +       C  P    NG   G+    G   +VT+ C+ G+ + G+  I 
Sbjct: 1378 SGFSIQFSTSIAAT----CNDPGMPQNGTRYGDSREAG--DTVTFQCDPGYQLQGQAKIT 1431

Query: 267  CTVNNDEGEWSGPPPEC 283
            C   N+   W   PP C
Sbjct: 1432 CVQLNNRFFWQPDPPTC 1448



 Score = 37.4 bits (85), Expect = 0.023
 Identities = 19/59 (32%), Positives = 27/59 (45%), Gaps = 3/59 (5%)

Query: 225  CPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPEC 283
            CP PP   NG +      Y   QSV++ C  G+ +IG H +    +     W+ P P C
Sbjct: 2088 CPDPPPFQNGYMINS--DYSVGQSVSFECYPGYILIG-HPVLTCQHGINRNWNYPFPRC 2143



 Score = 35.4 bits (80), Expect = 0.086
 Identities = 52/231 (22%), Positives = 86/231 (37%), Gaps = 31/231 (13%)

Query: 61  ITYKCEESFVKIPGEKDSVICLKGSQ--WSDIEEFCNRSCEVPTRLNSASLKQPYITQNY 118
           +++ C++ FVK  G +     L+     WS     C   C      +S  +  P     Y
Sbjct: 720 VSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEAPCGGHLTASSGVILPPG-WPGY 778

Query: 119 FPVGTVVEY--ECRPGYRREPSLSPKLTCLQNLKWSTA-VEFCKKKSCPNPGEIRNGQID 175
           +      E+  E +PG+  + +     T    + + T  V      S P  GE    Q  
Sbjct: 779 YKDSLHCEWIIEAKPGHSIKITFDRFQT---EVNYDTLEVRDGPASSSPLIGEYHGTQAP 835

Query: 176 VPGGILFGATISFSCNTG---YKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQID 232
                       F  +TG   Y LF + +S   I G  + +     E      P  P   
Sbjct: 836 -----------QFLISTGNFMYLLFTTDNSRSSI-GFLIHYESVTLESDSCLDPGIPV-- 881

Query: 233 NGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPEC 283
           NG   G    +G R +VT++C+ G+T+  +  + C  N+   +W+   P C
Sbjct: 882 NGHRHG--GDFGIRSTVTFSCDPGYTLSDDEPLVCERNH---QWNHALPSC 927



 Score = 35.0 bits (79), Expect = 0.11
 Identities = 16/68 (23%), Positives = 33/68 (48%), Gaps = 1/68 (1%)

Query: 225  CPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECR 284
            C  PP +    +  E D +     V Y C+ G+T++G   + C +++ + ++ G  P C 
Sbjct: 2259 CQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSS-QLQFEGSLPTCE 2317

Query: 285  GKSLTSKV 292
             +   ++V
Sbjct: 2318 AQCPANEV 2325



 Score = 34.3 bits (77), Expect = 0.19
 Identities = 17/51 (33%), Positives = 25/51 (49%), Gaps = 10/51 (19%)

Query: 242  HYGYR---------QSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPEC 283
            +YGYR           V Y+CN G+ M G +++ C ++ D   W  P P C
Sbjct: 1225 NYGYRIRDEGHFTDTVVLYSCNPGYAMHGSNTLTC-LSGDRRVWDKPLPSC 1274



 Score = 33.9 bits (76), Expect = 0.25
 Identities = 14/36 (38%), Positives = 20/36 (55%), Gaps = 3/36 (8%)

Query: 248 SVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPEC 283
           ++T+ C   F ++GE  I C  NN   +WSG  P C
Sbjct: 549 TLTFECPAAFELVGERVITCQQNN---QWSGNKPSC 581



 Score = 33.9 bits (76), Expect = 0.25
 Identities = 22/71 (30%), Positives = 31/71 (43%), Gaps = 2/71 (2%)

Query: 157  FCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDP 216
            F  KK  P P   +   +        G  + + C+ GY L G+    C +S S +Q+   
Sbjct: 2254 FQLKKCQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLS-SQLQFEGS 2312

Query: 217  LPECREIYCPA 227
            LP C E  CPA
Sbjct: 2313 LPTC-EAQCPA 2322



 Score = 32.7 bits (73), Expect = 0.56
 Identities = 38/139 (27%), Positives = 58/139 (41%), Gaps = 18/139 (12%)

Query: 162  SCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECR 221
            SC +PG   NG     G     +T++FSC+ GY L   +    L+   + QW+  LP C 
Sbjct: 873  SCLDPGIPVNGHRH-GGDFGIRSTVTFSCDPGYTL---SDDEPLVCERNHQWNHALPSC- 927

Query: 222  EIYCPAPPQIDNGII--QGERDHYGYRQSVTYAC----NKGFTMIGEHSIYCTVNND--- 272
            +  C    Q  +G +   G  D Y    + T+       KG  MI  H+ +   ++D   
Sbjct: 928  DALCGGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMI-FHTFHLESSHDYLL 986

Query: 273  ---EGEWSGPPPECRGKSL 288
               +G +S P     G  L
Sbjct: 987  ITEDGSFSEPVARLTGSVL 1005



 Score = 32.0 bits (71), Expect = 0.95
 Identities = 25/87 (28%), Positives = 39/87 (44%), Gaps = 9/87 (10%)

Query: 34  GDCGLPPDVPNAQPALEGRT--SFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIE 91
           G CG P       PA   RT  SF     +T++C  +F ++ GE+  + C + +QWS  +
Sbjct: 526 GGCGDP-----GIPAYGKRTGSSFLHGDTLTFECPAAF-ELVGER-VITCQQNNQWSGNK 578

Query: 92  EFCNRSCEVPTRLNSASLKQPYITQNY 118
             C  SC      +S  +  P   + Y
Sbjct: 579 PSCVFSCFFNFTASSGIILSPNYPEEY 605



 Score = 32.0 bits (71), Expect = 0.95
 Identities = 19/73 (26%), Positives = 34/73 (46%), Gaps = 5/73 (6%)

Query: 148  NLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLIS 207
            ++++ST++      +C +PG  +NG          G T++F C+ GY+L G     C+  
Sbjct: 1381 SIQFSTSIA----ATCNDPGMPQNGT-RYGDSREAGDTVTFQCDPGYQLQGQAKITCVQL 1435

Query: 208  GSSVQWSDPLPEC 220
             +   W    P C
Sbjct: 1436 NNRFFWQPDPPTC 1448



 Score = 31.6 bits (70), Expect = 1.2
 Identities = 13/42 (30%), Positives = 21/42 (50%), Gaps = 1/42 (2%)

Query: 242  HYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPEC 283
            H+G   S+T++C  G+ + G   + C +      WS P P C
Sbjct: 1061 HFGVGDSLTFSCFLGYRLEGATKLTC-LGGGRRVWSAPLPRC 1101



 Score = 30.8 bits (68), Expect = 2.1
 Identities = 48/238 (20%), Positives = 84/238 (35%), Gaps = 24/238 (10%)

Query: 53   TSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQ----WSDIEEFCNRSCEVPTRLNSAS 108
            T F   + ITY+C+  +  +  +  S+ C+ G+     W  +   CN  C      +   
Sbjct: 1579 TDFKLGSTITYQCDSGYKIL--DPSSITCVIGADGKPSWDQVLPSCNAPCGGQYTGSEGV 1636

Query: 109  LKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCL--QNLKWSTAVEFCKKKSCPNP 166
            +  P    NY   G +  Y             PK   +  Q   + TA+    +      
Sbjct: 1637 VLSPNYPHNY-TAGQICLYSITV---------PKEFVVFGQFAYFQTALNDLAELFDGTH 1686

Query: 167  GEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCP 226
             + R   +    G   G T+  + +    L  S  S     G    +   +P   +  C 
Sbjct: 1687 AQAR--LLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGFHFVYQ-AVPRTSDTQCS 1743

Query: 227  APPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYC-TVNNDEGEWSGPPPEC 283
            + P+   G   G     G    V + CN G+ + G  +++C +V N   +W+   P C
Sbjct: 1744 SVPEPRYGRRIGSEFSAG--SIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSC 1799



 Score = 30.8 bits (68), Expect = 2.1
 Identities = 51/247 (20%), Positives = 83/247 (33%), Gaps = 63/247 (25%)

Query: 96   RSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTC--LQNLKWST 153
            + C+ P  +  A +       + F +G  V+Y+C PGY      +  LTC     L++  
Sbjct: 2257 KKCQPPPAVPQAEM---LTEDDDFEIGDFVKYQCHPGYTLVG--TDILTCKLSSQLQFEG 2311

Query: 154  AVEFCKKKSCPNPGEIRNGQIDV------PGGILFGATISFSC----NTGYKLF------ 197
            ++  C+ + CP   E+R G   V      PG      T S+S     N    +F      
Sbjct: 2312 SLPTCEAQ-CP-ANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQS 2369

Query: 198  --------------GSTSSFCLISGSSVQWSDPLPECREI-------------------- 223
                          G +    ++SG+  + S+      ++                    
Sbjct: 2370 EKQFDALEVFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYA 2429

Query: 224  --YCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNN-DEGEWSGPP 280
              YC     + NG I   R        V Y C  G+ M+G  +  C  N     +W    
Sbjct: 2430 APYCSLTHPLKNGGIL-NRTAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLT 2488

Query: 281  PECRGKS 287
            P C+  S
Sbjct: 2489 PLCQAVS 2495



 Score = 30.4 bits (67), Expect = 2.8
 Identities = 20/56 (35%), Positives = 26/56 (46%), Gaps = 4/56 (7%)

Query: 232 DNGI-IQGER--DHYGYRQSVTYACNKGFTMI-GEHSIYCTVNNDEGEWSGPPPEC 283
           D GI I G R  D +    SV++ C+ GF    G  SI C + +    WS   P C
Sbjct: 700 DPGIPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRC 755



 Score = 30.0 bits (66), Expect = 3.6
 Identities = 16/59 (27%), Positives = 27/59 (45%), Gaps = 2/59 (3%)

Query: 162  SCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPEC 220
            +C  P  + +  I +    +    +SF C  GY L G +   C+  G+  +W+ P P C
Sbjct: 1915 ACQEPA-LPSNSIKIGDRYMVNDVLSFQCEPGYTLQGRSHISCM-PGTVRRWNYPSPLC 1971



 Score = 29.6 bits (65), Expect = 4.7
 Identities = 18/62 (29%), Positives = 27/62 (43%), Gaps = 3/62 (4%)

Query: 119  FPVGTVVEYECRPGYRREPSLSPKLTCLQN--LKWSTAVEFCKKKSCPNPGEIRNGQIDV 176
            F  G++V +EC PGY  + S +     + N   +W+  +  C    C      R G I  
Sbjct: 1758 FSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSC-VVPCSGNFTQRRGTILS 1816

Query: 177  PG 178
            PG
Sbjct: 1817 PG 1818



 Score = 28.9 bits (63), Expect = 8.0
 Identities = 17/59 (28%), Positives = 25/59 (42%), Gaps = 3/59 (5%)

Query: 225  CPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPEC 283
            C  P    N I  G+R  Y     +++ C  G+T+ G   I C +      W+ P P C
Sbjct: 1916 CQEPALPSNSIKIGDR--YMVNDVLSFQCEPGYTLQGRSHISC-MPGTVRRWNYPSPLC 1971


>gi|27502421 CD46 antigen, complement regulatory protein isoform 13
           precursor [Homo sapiens]
          Length = 373

 Score =  107 bits (266), Expect = 2e-23
 Identities = 64/196 (32%), Positives = 96/196 (48%), Gaps = 13/196 (6%)

Query: 97  SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKW-STAV 155
           +CE P    +  L      + Y+ +G  V+Y+C+ GY   P L+    C +N  W   + 
Sbjct: 34  ACEEPPTFEAMELIGK--PKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 156 EFCKKKSCPNPGEIRNGQ-IDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWS 214
           + C +++CP   +  NGQ +   G   FG  + F CN GY L G    +C + GS   WS
Sbjct: 92  DACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWS 151

Query: 215 DPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG-----FTMIGEHSIYCT 268
              P C ++ C  PP+I NG     E + + Y  +VTY+C+       F++IGE +IYC 
Sbjct: 152 GKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC- 210

Query: 269 VNNDEGEWSGPPPECR 284
              D   WS   PEC+
Sbjct: 211 --GDNSVWSRAAPECK 224



 Score = 79.0 bits (193), Expect = 7e-15
 Identities = 74/307 (24%), Positives = 122/307 (39%), Gaps = 29/307 (9%)

Query: 19  PRLLLLVLLCLPAVWGD-CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKD 77
           P LLL  ++ L   + D C  PP     +   + +  +     + YKC++ +  IP    
Sbjct: 17  PGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLAT 76

Query: 78  SVICLKGSQWSDI-EEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRR- 135
             IC +   W  + ++ C R  E    +      Q       +  G  + + C  GY   
Sbjct: 77  HTICDRNHTWLPVSDDACYR--ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLI 134

Query: 136 -EPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGA--TISFSCNT 192
            E  L  +L     + WS     C+K  C  P +I+NG+       +F     +++SC+ 
Sbjct: 135 GEEILYCELKGSVAI-WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP 193

Query: 193 G-----YKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQ 247
                 + L G ++ +C   G +  WS   PEC+ + C  P   +   I G    + Y+ 
Sbjct: 194 APGPDPFSLIGESTIYC---GDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKA 250

Query: 248 SVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKV---------PPTVQK 298
           +V + C+KGF + G  +I C  N+    W  P P+C   S +S           P    K
Sbjct: 251 TVMFECDKGFYLDGSDTIVCDSNS---TWDPPVPKCLKVSTSSTTKSPASSASGPRPTYK 307

Query: 299 PTTVNVP 305
           P   N P
Sbjct: 308 PPVSNYP 314


>gi|27502419 CD46 antigen, complement regulatory protein isoform 11
           precursor [Homo sapiens]
          Length = 348

 Score =  107 bits (266), Expect = 2e-23
 Identities = 64/196 (32%), Positives = 96/196 (48%), Gaps = 13/196 (6%)

Query: 97  SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKW-STAV 155
           +CE P    +  L      + Y+ +G  V+Y+C+ GY   P L+    C +N  W   + 
Sbjct: 34  ACEEPPTFEAMELIGK--PKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 156 EFCKKKSCPNPGEIRNGQ-IDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWS 214
           + C +++CP   +  NGQ +   G   FG  + F CN GY L G    +C + GS   WS
Sbjct: 92  DACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWS 151

Query: 215 DPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG-----FTMIGEHSIYCT 268
              P C ++ C  PP+I NG     E + + Y  +VTY+C+       F++IGE +IYC 
Sbjct: 152 GKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC- 210

Query: 269 VNNDEGEWSGPPPECR 284
              D   WS   PEC+
Sbjct: 211 --GDNSVWSRAAPECK 224



 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 67/276 (24%), Positives = 114/276 (41%), Gaps = 20/276 (7%)

Query: 19  PRLLLLVLLCLPAVWGD-CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKD 77
           P LLL  ++ L   + D C  PP     +   + +  +     + YKC++ +  IP    
Sbjct: 17  PGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLAT 76

Query: 78  SVICLKGSQWSDI-EEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRR- 135
             IC +   W  + ++ C R  E    +      Q       +  G  + + C  GY   
Sbjct: 77  HTICDRNHTWLPVSDDACYR--ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLI 134

Query: 136 -EPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGA--TISFSCNT 192
            E  L  +L     + WS     C+K  C  P +I+NG+       +F     +++SC+ 
Sbjct: 135 GEEILYCELKGSVAI-WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP 193

Query: 193 G-----YKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQ 247
                 + L G ++ +C   G +  WS   PEC+ + C  P   +   I G    + Y+ 
Sbjct: 194 APGPDPFSLIGESTIYC---GDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKA 250

Query: 248 SVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPEC 283
           +V + C+KGF + G  +I C  N+    W  P P+C
Sbjct: 251 TVMFECDKGFYLDGSDTIVCDSNS---TWDPPVPKC 283


>gi|27502417 CD46 antigen, complement regulatory protein isoform 10
           precursor [Homo sapiens]
          Length = 370

 Score =  107 bits (266), Expect = 2e-23
 Identities = 64/196 (32%), Positives = 96/196 (48%), Gaps = 13/196 (6%)

Query: 97  SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKW-STAV 155
           +CE P    +  L      + Y+ +G  V+Y+C+ GY   P L+    C +N  W   + 
Sbjct: 34  ACEEPPTFEAMELIGK--PKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 156 EFCKKKSCPNPGEIRNGQ-IDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWS 214
           + C +++CP   +  NGQ +   G   FG  + F CN GY L G    +C + GS   WS
Sbjct: 92  DACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWS 151

Query: 215 DPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG-----FTMIGEHSIYCT 268
              P C ++ C  PP+I NG     E + + Y  +VTY+C+       F++IGE +IYC 
Sbjct: 152 GKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC- 210

Query: 269 VNNDEGEWSGPPPECR 284
              D   WS   PEC+
Sbjct: 211 --GDNSVWSRAAPECK 224



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 69/283 (24%), Positives = 117/283 (41%), Gaps = 20/283 (7%)

Query: 19  PRLLLLVLLCLPAVWGD-CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKD 77
           P LLL  ++ L   + D C  PP     +   + +  +     + YKC++ +  IP    
Sbjct: 17  PGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLAT 76

Query: 78  SVICLKGSQWSDI-EEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRR- 135
             IC +   W  + ++ C R  E    +      Q       +  G  + + C  GY   
Sbjct: 77  HTICDRNHTWLPVSDDACYR--ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLI 134

Query: 136 -EPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGA--TISFSCNT 192
            E  L  +L     + WS     C+K  C  P +I+NG+       +F     +++SC+ 
Sbjct: 135 GEEILYCELKGSVAI-WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP 193

Query: 193 G-----YKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQ 247
                 + L G ++ +C   G +  WS   PEC+ + C  P   +   I G    + Y+ 
Sbjct: 194 APGPDPFSLIGESTIYC---GDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKA 250

Query: 248 SVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTS 290
           +V + C+KGF + G  +I C  N+    W  P P+C   S +S
Sbjct: 251 TVMFECDKGFYLDGSDTIVCDSNS---TWDPPVPKCLKVSTSS 290


>gi|27502415 CD46 antigen, complement regulatory protein isoform 9
           precursor [Homo sapiens]
          Length = 363

 Score =  107 bits (266), Expect = 2e-23
 Identities = 64/196 (32%), Positives = 96/196 (48%), Gaps = 13/196 (6%)

Query: 97  SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKW-STAV 155
           +CE P    +  L      + Y+ +G  V+Y+C+ GY   P L+    C +N  W   + 
Sbjct: 34  ACEEPPTFEAMELIGK--PKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 156 EFCKKKSCPNPGEIRNGQ-IDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWS 214
           + C +++CP   +  NGQ +   G   FG  + F CN GY L G    +C + GS   WS
Sbjct: 92  DACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWS 151

Query: 215 DPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG-----FTMIGEHSIYCT 268
              P C ++ C  PP+I NG     E + + Y  +VTY+C+       F++IGE +IYC 
Sbjct: 152 GKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC- 210

Query: 269 VNNDEGEWSGPPPECR 284
              D   WS   PEC+
Sbjct: 211 --GDNSVWSRAAPECK 224



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 69/283 (24%), Positives = 117/283 (41%), Gaps = 20/283 (7%)

Query: 19  PRLLLLVLLCLPAVWGD-CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKD 77
           P LLL  ++ L   + D C  PP     +   + +  +     + YKC++ +  IP    
Sbjct: 17  PGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLAT 76

Query: 78  SVICLKGSQWSDI-EEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRR- 135
             IC +   W  + ++ C R  E    +      Q       +  G  + + C  GY   
Sbjct: 77  HTICDRNHTWLPVSDDACYR--ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLI 134

Query: 136 -EPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGA--TISFSCNT 192
            E  L  +L     + WS     C+K  C  P +I+NG+       +F     +++SC+ 
Sbjct: 135 GEEILYCELKGSVAI-WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP 193

Query: 193 G-----YKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQ 247
                 + L G ++ +C   G +  WS   PEC+ + C  P   +   I G    + Y+ 
Sbjct: 194 APGPDPFSLIGESTIYC---GDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKA 250

Query: 248 SVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTS 290
           +V + C+KGF + G  +I C  N+    W  P P+C   S +S
Sbjct: 251 TVMFECDKGFYLDGSDTIVCDSNS---TWDPPVPKCLKVSTSS 290


>gi|27502413 CD46 antigen, complement regulatory protein isoform 7
           precursor [Homo sapiens]
          Length = 378

 Score =  107 bits (266), Expect = 2e-23
 Identities = 64/196 (32%), Positives = 96/196 (48%), Gaps = 13/196 (6%)

Query: 97  SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKW-STAV 155
           +CE P    +  L      + Y+ +G  V+Y+C+ GY   P L+    C +N  W   + 
Sbjct: 34  ACEEPPTFEAMELIGK--PKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 156 EFCKKKSCPNPGEIRNGQ-IDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWS 214
           + C +++CP   +  NGQ +   G   FG  + F CN GY L G    +C + GS   WS
Sbjct: 92  DACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWS 151

Query: 215 DPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG-----FTMIGEHSIYCT 268
              P C ++ C  PP+I NG     E + + Y  +VTY+C+       F++IGE +IYC 
Sbjct: 152 GKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC- 210

Query: 269 VNNDEGEWSGPPPECR 284
              D   WS   PEC+
Sbjct: 211 --GDNSVWSRAAPECK 224



 Score = 82.4 bits (202), Expect = 6e-16
 Identities = 74/319 (23%), Positives = 130/319 (40%), Gaps = 25/319 (7%)

Query: 19  PRLLLLVLLCLPAVWGD-CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKD 77
           P LLL  ++ L   + D C  PP     +   + +  +     + YKC++ +  IP    
Sbjct: 17  PGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLAT 76

Query: 78  SVICLKGSQWSDI-EEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRR- 135
             IC +   W  + ++ C R  E    +      Q       +  G  + + C  GY   
Sbjct: 77  HTICDRNHTWLPVSDDACYR--ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLI 134

Query: 136 -EPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGA--TISFSCNT 192
            E  L  +L     + WS     C+K  C  P +I+NG+       +F     +++SC+ 
Sbjct: 135 GEEILYCELKGSVAI-WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP 193

Query: 193 G-----YKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQ 247
                 + L G ++ +C   G +  WS   PEC+ + C  P   +   I G    + Y+ 
Sbjct: 194 APGPDPFSLIGESTIYC---GDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKA 250

Query: 248 SVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVNVPTT 307
           +V + C+KGF + G  +I C  N+    W  P P+C        +PP+  KP  ++   +
Sbjct: 251 TVMFECDKGFYLDGSDTIVCDSNS---TWDPPVPKC-----LKVLPPSSTKPPALSHSVS 302

Query: 308 EVSPTSQKTTTKTTTPNAQ 326
             S T    ++ +  P  +
Sbjct: 303 TSSTTKSPASSASGYPKPE 321


>gi|27502411 CD46 antigen, complement regulatory protein isoform 6
           precursor [Homo sapiens]
          Length = 369

 Score =  107 bits (266), Expect = 2e-23
 Identities = 64/196 (32%), Positives = 96/196 (48%), Gaps = 13/196 (6%)

Query: 97  SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKW-STAV 155
           +CE P    +  L      + Y+ +G  V+Y+C+ GY   P L+    C +N  W   + 
Sbjct: 34  ACEEPPTFEAMELIGK--PKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 156 EFCKKKSCPNPGEIRNGQ-IDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWS 214
           + C +++CP   +  NGQ +   G   FG  + F CN GY L G    +C + GS   WS
Sbjct: 92  DACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWS 151

Query: 215 DPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG-----FTMIGEHSIYCT 268
              P C ++ C  PP+I NG     E + + Y  +VTY+C+       F++IGE +IYC 
Sbjct: 152 GKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC- 210

Query: 269 VNNDEGEWSGPPPECR 284
              D   WS   PEC+
Sbjct: 211 --GDNSVWSRAAPECK 224



 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 73/298 (24%), Positives = 120/298 (40%), Gaps = 26/298 (8%)

Query: 19  PRLLLLVLLCLPAVWGD-CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKD 77
           P LLL  ++ L   + D C  PP     +   + +  +     + YKC++ +  IP    
Sbjct: 17  PGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLAT 76

Query: 78  SVICLKGSQWSDI-EEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRR- 135
             IC +   W  + ++ C R  E    +      Q       +  G  + + C  GY   
Sbjct: 77  HTICDRNHTWLPVSDDACYR--ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLI 134

Query: 136 -EPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGA--TISFSCNT 192
            E  L  +L     + WS     C+K  C  P +I+NG+       +F     +++SC+ 
Sbjct: 135 GEEILYCELKGSVAI-WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP 193

Query: 193 G-----YKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQ 247
                 + L G ++ +C   G +  WS   PEC+ + C  P   +   I G    + Y+ 
Sbjct: 194 APGPDPFSLIGESTIYC---GDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKA 250

Query: 248 SVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVNVP 305
           +V + C+KGF + G  +I C  N+    W  P P+C       K P    KP   N P
Sbjct: 251 TVMFECDKGFYLDGSDTIVCDSNS---TWDPPVPKC------LKGPRPTYKPPVSNYP 299


>gi|27502409 CD46 antigen, complement regulatory protein isoform 5
           precursor [Homo sapiens]
          Length = 362

 Score =  107 bits (266), Expect = 2e-23
 Identities = 64/196 (32%), Positives = 96/196 (48%), Gaps = 13/196 (6%)

Query: 97  SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKW-STAV 155
           +CE P    +  L      + Y+ +G  V+Y+C+ GY   P L+    C +N  W   + 
Sbjct: 34  ACEEPPTFEAMELIGK--PKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 156 EFCKKKSCPNPGEIRNGQ-IDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWS 214
           + C +++CP   +  NGQ +   G   FG  + F CN GY L G    +C + GS   WS
Sbjct: 92  DACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWS 151

Query: 215 DPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG-----FTMIGEHSIYCT 268
              P C ++ C  PP+I NG     E + + Y  +VTY+C+       F++IGE +IYC 
Sbjct: 152 GKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC- 210

Query: 269 VNNDEGEWSGPPPECR 284
              D   WS   PEC+
Sbjct: 211 --GDNSVWSRAAPECK 224



 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 73/298 (24%), Positives = 120/298 (40%), Gaps = 26/298 (8%)

Query: 19  PRLLLLVLLCLPAVWGD-CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKD 77
           P LLL  ++ L   + D C  PP     +   + +  +     + YKC++ +  IP    
Sbjct: 17  PGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLAT 76

Query: 78  SVICLKGSQWSDI-EEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRR- 135
             IC +   W  + ++ C R  E    +      Q       +  G  + + C  GY   
Sbjct: 77  HTICDRNHTWLPVSDDACYR--ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLI 134

Query: 136 -EPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGA--TISFSCNT 192
            E  L  +L     + WS     C+K  C  P +I+NG+       +F     +++SC+ 
Sbjct: 135 GEEILYCELKGSVAI-WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP 193

Query: 193 G-----YKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQ 247
                 + L G ++ +C   G +  WS   PEC+ + C  P   +   I G    + Y+ 
Sbjct: 194 APGPDPFSLIGESTIYC---GDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKA 250

Query: 248 SVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVNVP 305
           +V + C+KGF + G  +I C  N+    W  P P+C       K P    KP   N P
Sbjct: 251 TVMFECDKGFYLDGSDTIVCDSNS---TWDPPVPKC------LKGPRPTYKPPVSNYP 299


>gi|27502407 CD46 antigen, complement regulatory protein isoform 3
           precursor [Homo sapiens]
          Length = 377

 Score =  107 bits (266), Expect = 2e-23
 Identities = 64/196 (32%), Positives = 96/196 (48%), Gaps = 13/196 (6%)

Query: 97  SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKW-STAV 155
           +CE P    +  L      + Y+ +G  V+Y+C+ GY   P L+    C +N  W   + 
Sbjct: 34  ACEEPPTFEAMELIGK--PKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 156 EFCKKKSCPNPGEIRNGQ-IDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWS 214
           + C +++CP   +  NGQ +   G   FG  + F CN GY L G    +C + GS   WS
Sbjct: 92  DACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWS 151

Query: 215 DPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG-----FTMIGEHSIYCT 268
              P C ++ C  PP+I NG     E + + Y  +VTY+C+       F++IGE +IYC 
Sbjct: 152 GKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC- 210

Query: 269 VNNDEGEWSGPPPECR 284
              D   WS   PEC+
Sbjct: 211 --GDNSVWSRAAPECK 224



 Score = 79.0 bits (193), Expect = 7e-15
 Identities = 74/307 (24%), Positives = 122/307 (39%), Gaps = 29/307 (9%)

Query: 19  PRLLLLVLLCLPAVWGD-CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKD 77
           P LLL  ++ L   + D C  PP     +   + +  +     + YKC++ +  IP    
Sbjct: 17  PGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLAT 76

Query: 78  SVICLKGSQWSDI-EEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRR- 135
             IC +   W  + ++ C R  E    +      Q       +  G  + + C  GY   
Sbjct: 77  HTICDRNHTWLPVSDDACYR--ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLI 134

Query: 136 -EPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGA--TISFSCNT 192
            E  L  +L     + WS     C+K  C  P +I+NG+       +F     +++SC+ 
Sbjct: 135 GEEILYCELKGSVAI-WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP 193

Query: 193 G-----YKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQ 247
                 + L G ++ +C   G +  WS   PEC+ + C  P   +   I G    + Y+ 
Sbjct: 194 APGPDPFSLIGESTIYC---GDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKA 250

Query: 248 SVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKV---------PPTVQK 298
           +V + C+KGF + G  +I C  N+    W  P P+C   S +S           P    K
Sbjct: 251 TVMFECDKGFYLDGSDTIVCDSNS---TWDPPVPKCLKVSTSSTTKSPASSASGPRPTYK 307

Query: 299 PTTVNVP 305
           P   N P
Sbjct: 308 PPVSNYP 314


>gi|27502405 CD46 antigen, complement regulatory protein isoform 14
           precursor [Homo sapiens]
          Length = 349

 Score =  107 bits (266), Expect = 2e-23
 Identities = 64/196 (32%), Positives = 96/196 (48%), Gaps = 13/196 (6%)

Query: 97  SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKW-STAV 155
           +CE P    +  L      + Y+ +G  V+Y+C+ GY   P L+    C +N  W   + 
Sbjct: 34  ACEEPPTFEAMELIGK--PKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 156 EFCKKKSCPNPGEIRNGQ-IDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWS 214
           + C +++CP   +  NGQ +   G   FG  + F CN GY L G    +C + GS   WS
Sbjct: 92  DACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWS 151

Query: 215 DPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG-----FTMIGEHSIYCT 268
              P C ++ C  PP+I NG     E + + Y  +VTY+C+       F++IGE +IYC 
Sbjct: 152 GKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC- 210

Query: 269 VNNDEGEWSGPPPECR 284
              D   WS   PEC+
Sbjct: 211 --GDNSVWSRAAPECK 224



 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 73/298 (24%), Positives = 120/298 (40%), Gaps = 26/298 (8%)

Query: 19  PRLLLLVLLCLPAVWGD-CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKD 77
           P LLL  ++ L   + D C  PP     +   + +  +     + YKC++ +  IP    
Sbjct: 17  PGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLAT 76

Query: 78  SVICLKGSQWSDI-EEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRR- 135
             IC +   W  + ++ C R  E    +      Q       +  G  + + C  GY   
Sbjct: 77  HTICDRNHTWLPVSDDACYR--ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLI 134

Query: 136 -EPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGA--TISFSCNT 192
            E  L  +L     + WS     C+K  C  P +I+NG+       +F     +++SC+ 
Sbjct: 135 GEEILYCELKGSVAI-WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP 193

Query: 193 G-----YKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQ 247
                 + L G ++ +C   G +  WS   PEC+ + C  P   +   I G    + Y+ 
Sbjct: 194 APGPDPFSLIGESTIYC---GDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKA 250

Query: 248 SVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVNVP 305
           +V + C+KGF + G  +I C  N+    W  P P+C       K P    KP   N P
Sbjct: 251 TVMFECDKGFYLDGSDTIVCDSNS---TWDPPVPKC------LKGPRPTYKPPVSNYP 299


>gi|27502402 CD46 antigen, complement regulatory protein isoform 1
           precursor [Homo sapiens]
          Length = 392

 Score =  107 bits (266), Expect = 2e-23
 Identities = 64/196 (32%), Positives = 96/196 (48%), Gaps = 13/196 (6%)

Query: 97  SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKW-STAV 155
           +CE P    +  L      + Y+ +G  V+Y+C+ GY   P L+    C +N  W   + 
Sbjct: 34  ACEEPPTFEAMELIGK--PKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 156 EFCKKKSCPNPGEIRNGQ-IDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWS 214
           + C +++CP   +  NGQ +   G   FG  + F CN GY L G    +C + GS   WS
Sbjct: 92  DACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWS 151

Query: 215 DPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG-----FTMIGEHSIYCT 268
              P C ++ C  PP+I NG     E + + Y  +VTY+C+       F++IGE +IYC 
Sbjct: 152 GKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC- 210

Query: 269 VNNDEGEWSGPPPECR 284
              D   WS   PEC+
Sbjct: 211 --GDNSVWSRAAPECK 224



 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 81/330 (24%), Positives = 135/330 (40%), Gaps = 34/330 (10%)

Query: 19  PRLLLLVLLCLPAVWGD-CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKD 77
           P LLL  ++ L   + D C  PP     +   + +  +     + YKC++ +  IP    
Sbjct: 17  PGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLAT 76

Query: 78  SVICLKGSQWSDI-EEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRR- 135
             IC +   W  + ++ C R  E    +      Q       +  G  + + C  GY   
Sbjct: 77  HTICDRNHTWLPVSDDACYR--ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLI 134

Query: 136 -EPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGA--TISFSCNT 192
            E  L  +L     + WS     C+K  C  P +I+NG+       +F     +++SC+ 
Sbjct: 135 GEEILYCELKGSVAI-WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP 193

Query: 193 G-----YKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQ 247
                 + L G ++ +C   G +  WS   PEC+ + C  P   +   I G    + Y+ 
Sbjct: 194 APGPDPFSLIGESTIYC---GDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKA 250

Query: 248 SVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVNVPTT 307
           +V + C+KGF + G  +I C  N+    W  P P+C        +PP+  KP  ++    
Sbjct: 251 TVMFECDKGFYLDGSDTIVCDSNS---TWDPPVPKC-----LKVLPPSSTKPPALS---- 298

Query: 308 EVSPTSQKTTTKTTTPNAQATRST---PVS 334
                S  +TTK+   +A   R T   PVS
Sbjct: 299 --HSVSTSSTTKSPASSASGPRPTYKPPVS 326


>gi|24432108 CD46 antigen, complement regulatory protein isoform 4
           precursor [Homo sapiens]
          Length = 384

 Score =  107 bits (266), Expect = 2e-23
 Identities = 64/196 (32%), Positives = 96/196 (48%), Gaps = 13/196 (6%)

Query: 97  SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKW-STAV 155
           +CE P    +  L      + Y+ +G  V+Y+C+ GY   P L+    C +N  W   + 
Sbjct: 34  ACEEPPTFEAMELIGK--PKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 156 EFCKKKSCPNPGEIRNGQ-IDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWS 214
           + C +++CP   +  NGQ +   G   FG  + F CN GY L G    +C + GS   WS
Sbjct: 92  DACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWS 151

Query: 215 DPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG-----FTMIGEHSIYCT 268
              P C ++ C  PP+I NG     E + + Y  +VTY+C+       F++IGE +IYC 
Sbjct: 152 GKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC- 210

Query: 269 VNNDEGEWSGPPPECR 284
              D   WS   PEC+
Sbjct: 211 --GDNSVWSRAAPECK 224



 Score = 79.0 bits (193), Expect = 7e-15
 Identities = 74/307 (24%), Positives = 122/307 (39%), Gaps = 29/307 (9%)

Query: 19  PRLLLLVLLCLPAVWGD-CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKD 77
           P LLL  ++ L   + D C  PP     +   + +  +     + YKC++ +  IP    
Sbjct: 17  PGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLAT 76

Query: 78  SVICLKGSQWSDI-EEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRR- 135
             IC +   W  + ++ C R  E    +      Q       +  G  + + C  GY   
Sbjct: 77  HTICDRNHTWLPVSDDACYR--ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLI 134

Query: 136 -EPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGA--TISFSCNT 192
            E  L  +L     + WS     C+K  C  P +I+NG+       +F     +++SC+ 
Sbjct: 135 GEEILYCELKGSVAI-WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP 193

Query: 193 G-----YKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQ 247
                 + L G ++ +C   G +  WS   PEC+ + C  P   +   I G    + Y+ 
Sbjct: 194 APGPDPFSLIGESTIYC---GDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKA 250

Query: 248 SVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKV---------PPTVQK 298
           +V + C+KGF + G  +I C  N+    W  P P+C   S +S           P    K
Sbjct: 251 TVMFECDKGFYLDGSDTIVCDSNS---TWDPPVPKCLKVSTSSTTKSPASSASGPRPTYK 307

Query: 299 PTTVNVP 305
           P   N P
Sbjct: 308 PPVSNYP 314


>gi|27502427 CD46 antigen, complement regulatory protein isoform 12
           precursor [Homo sapiens]
          Length = 355

 Score =  107 bits (266), Expect = 2e-23
 Identities = 64/196 (32%), Positives = 96/196 (48%), Gaps = 13/196 (6%)

Query: 97  SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKW-STAV 155
           +CE P    +  L      + Y+ +G  V+Y+C+ GY   P L+    C +N  W   + 
Sbjct: 34  ACEEPPTFEAMELIGK--PKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 156 EFCKKKSCPNPGEIRNGQ-IDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWS 214
           + C +++CP   +  NGQ +   G   FG  + F CN GY L G    +C + GS   WS
Sbjct: 92  DACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWS 151

Query: 215 DPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG-----FTMIGEHSIYCT 268
              P C ++ C  PP+I NG     E + + Y  +VTY+C+       F++IGE +IYC 
Sbjct: 152 GKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC- 210

Query: 269 VNNDEGEWSGPPPECR 284
              D   WS   PEC+
Sbjct: 211 --GDNSVWSRAAPECK 224



 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 67/276 (24%), Positives = 114/276 (41%), Gaps = 20/276 (7%)

Query: 19  PRLLLLVLLCLPAVWGD-CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKD 77
           P LLL  ++ L   + D C  PP     +   + +  +     + YKC++ +  IP    
Sbjct: 17  PGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLAT 76

Query: 78  SVICLKGSQWSDI-EEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRR- 135
             IC +   W  + ++ C R  E    +      Q       +  G  + + C  GY   
Sbjct: 77  HTICDRNHTWLPVSDDACYR--ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLI 134

Query: 136 -EPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGA--TISFSCNT 192
            E  L  +L     + WS     C+K  C  P +I+NG+       +F     +++SC+ 
Sbjct: 135 GEEILYCELKGSVAI-WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP 193

Query: 193 G-----YKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQ 247
                 + L G ++ +C   G +  WS   PEC+ + C  P   +   I G    + Y+ 
Sbjct: 194 APGPDPFSLIGESTIYC---GDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKA 250

Query: 248 SVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPEC 283
           +V + C+KGF + G  +I C  N+    W  P P+C
Sbjct: 251 TVMFECDKGFYLDGSDTIVCDSNS---TWDPPVPKC 283


>gi|27502425 CD46 antigen, complement regulatory protein isoform 8
           precursor [Homo sapiens]
          Length = 385

 Score =  107 bits (266), Expect = 2e-23
 Identities = 64/196 (32%), Positives = 96/196 (48%), Gaps = 13/196 (6%)

Query: 97  SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKW-STAV 155
           +CE P    +  L      + Y+ +G  V+Y+C+ GY   P L+    C +N  W   + 
Sbjct: 34  ACEEPPTFEAMELIGK--PKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 156 EFCKKKSCPNPGEIRNGQ-IDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWS 214
           + C +++CP   +  NGQ +   G   FG  + F CN GY L G    +C + GS   WS
Sbjct: 92  DACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWS 151

Query: 215 DPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG-----FTMIGEHSIYCT 268
              P C ++ C  PP+I NG     E + + Y  +VTY+C+       F++IGE +IYC 
Sbjct: 152 GKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC- 210

Query: 269 VNNDEGEWSGPPPECR 284
              D   WS   PEC+
Sbjct: 211 --GDNSVWSRAAPECK 224



 Score = 82.4 bits (202), Expect = 6e-16
 Identities = 74/319 (23%), Positives = 130/319 (40%), Gaps = 25/319 (7%)

Query: 19  PRLLLLVLLCLPAVWGD-CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKD 77
           P LLL  ++ L   + D C  PP     +   + +  +     + YKC++ +  IP    
Sbjct: 17  PGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLAT 76

Query: 78  SVICLKGSQWSDI-EEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRR- 135
             IC +   W  + ++ C R  E    +      Q       +  G  + + C  GY   
Sbjct: 77  HTICDRNHTWLPVSDDACYR--ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLI 134

Query: 136 -EPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGA--TISFSCNT 192
            E  L  +L     + WS     C+K  C  P +I+NG+       +F     +++SC+ 
Sbjct: 135 GEEILYCELKGSVAI-WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP 193

Query: 193 G-----YKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQ 247
                 + L G ++ +C   G +  WS   PEC+ + C  P   +   I G    + Y+ 
Sbjct: 194 APGPDPFSLIGESTIYC---GDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKA 250

Query: 248 SVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVNVPTT 307
           +V + C+KGF + G  +I C  N+    W  P P+C        +PP+  KP  ++   +
Sbjct: 251 TVMFECDKGFYLDGSDTIVCDSNS---TWDPPVPKC-----LKVLPPSSTKPPALSHSVS 302

Query: 308 EVSPTSQKTTTKTTTPNAQ 326
             S T    ++ +  P  +
Sbjct: 303 TSSTTKSPASSASGYPKPE 321


>gi|27502423 CD46 antigen, complement regulatory protein isoform 2
           precursor [Homo sapiens]
          Length = 399

 Score =  107 bits (266), Expect = 2e-23
 Identities = 64/196 (32%), Positives = 96/196 (48%), Gaps = 13/196 (6%)

Query: 97  SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKW-STAV 155
           +CE P    +  L      + Y+ +G  V+Y+C+ GY   P L+    C +N  W   + 
Sbjct: 34  ACEEPPTFEAMELIGK--PKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 156 EFCKKKSCPNPGEIRNGQ-IDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWS 214
           + C +++CP   +  NGQ +   G   FG  + F CN GY L G    +C + GS   WS
Sbjct: 92  DACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWS 151

Query: 215 DPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG-----FTMIGEHSIYCT 268
              P C ++ C  PP+I NG     E + + Y  +VTY+C+       F++IGE +IYC 
Sbjct: 152 GKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC- 210

Query: 269 VNNDEGEWSGPPPECR 284
              D   WS   PEC+
Sbjct: 211 --GDNSVWSRAAPECK 224



 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 81/330 (24%), Positives = 135/330 (40%), Gaps = 34/330 (10%)

Query: 19  PRLLLLVLLCLPAVWGD-CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKD 77
           P LLL  ++ L   + D C  PP     +   + +  +     + YKC++ +  IP    
Sbjct: 17  PGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLAT 76

Query: 78  SVICLKGSQWSDI-EEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRR- 135
             IC +   W  + ++ C R  E    +      Q       +  G  + + C  GY   
Sbjct: 77  HTICDRNHTWLPVSDDACYR--ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLI 134

Query: 136 -EPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGA--TISFSCNT 192
            E  L  +L     + WS     C+K  C  P +I+NG+       +F     +++SC+ 
Sbjct: 135 GEEILYCELKGSVAI-WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP 193

Query: 193 G-----YKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQ 247
                 + L G ++ +C   G +  WS   PEC+ + C  P   +   I G    + Y+ 
Sbjct: 194 APGPDPFSLIGESTIYC---GDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKA 250

Query: 248 SVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVNVPTT 307
           +V + C+KGF + G  +I C  N+    W  P P+C        +PP+  KP  ++    
Sbjct: 251 TVMFECDKGFYLDGSDTIVCDSNS---TWDPPVPKC-----LKVLPPSSTKPPALS---- 298

Query: 308 EVSPTSQKTTTKTTTPNAQATRST---PVS 334
                S  +TTK+   +A   R T   PVS
Sbjct: 299 --HSVSTSSTTKSPASSASGPRPTYKPPVS 326


>gi|166235140 seizure related 6 homolog (mouse)-like 2 isoform 4
           [Homo sapiens]
          Length = 809

 Score = 97.1 bits (240), Expect = 2e-20
 Identities = 60/168 (35%), Positives = 85/168 (50%), Gaps = 8/168 (4%)

Query: 122 GTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKK-KSCPNPGEIRNGQIDVP-GG 179
           GTV+ Y+C PGY  E   S  LTC  +L WS A   C+K  +C +PGEI NG       G
Sbjct: 551 GTVLTYQCEPGY--ELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAG 608

Query: 180 ILFGATISFSCNTGYKLFGSTSSFCLISGSSV-QWSDPLPECREIY--CPAPPQIDNGII 236
              G+ + + C  GY L G+    C    +   +WSD +P+C   Y  C  P   +NG  
Sbjct: 609 FPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQ 668

Query: 237 QGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECR 284
              + HY   +S+ + C +GF +IGE +I C V     +W+  PP C+
Sbjct: 669 TLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 715



 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 53/175 (30%), Positives = 75/175 (42%), Gaps = 17/175 (9%)

Query: 59  TVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNR--SCEVPTRLNSASLKQPYITQ 116
           TV+TY+CE  +  +    D + C     WS     C +  +C  P  + +        + 
Sbjct: 552 TVLTYQCEPGYELLGS--DILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTA---SD 606

Query: 117 NYFPVGTVVEYECRPGYRREPSLSPKLTCLQ----NLKWSTAVEFC--KKKSCPNPGEIR 170
             FPVG+ V+Y C PGY  E   +  LTC        KWS  V  C  K + C NPG   
Sbjct: 607 AGFPVGSHVQYRCLPGYSLEG--AAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPE 664

Query: 171 NG-QIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIY 224
           NG Q         G ++ F C  G++L G  +  C + G   QW+   P C+  Y
Sbjct: 665 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCKVAY 718



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 31/109 (28%), Positives = 49/109 (44%), Gaps = 7/109 (6%)

Query: 178 GGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIY-CPAPPQIDNGII 236
           G ++ G  +++ C  GY+L GS    C      + WS   P C++I  C  P +I NG  
Sbjct: 546 GDLIRGTVLTYQCEPGYELLGSDILTC---QWDLSWSAAPPACQKIMTCADPGEIANGHR 602

Query: 237 QGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEG--EWSGPPPEC 283
                 +     V Y C  G+++ G   + C  + D G  +WS   P+C
Sbjct: 603 TASDAGFPVGSHVQYRCLPGYSLEGAAMLTC-YSRDTGTPKWSDRVPKC 650



 Score = 36.2 bits (82), Expect = 0.050
 Identities = 21/63 (33%), Positives = 31/63 (49%), Gaps = 10/63 (15%)

Query: 162 SCPNPGEIRNGQIDV----PGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPL 217
           SC  P    +G + V    PGG     T +F C++GY+L G  +  CL +G+   W+   
Sbjct: 175 SCGFPPRPAHGDVSVTDLHPGG-----TATFHCDSGYQLQGEETLICL-NGTRPSWNGET 228

Query: 218 PEC 220
           P C
Sbjct: 229 PSC 231


>gi|166235138 seizure related 6 homolog (mouse)-like 2 isoform 3
           [Homo sapiens]
          Length = 840

 Score = 97.1 bits (240), Expect = 2e-20
 Identities = 60/168 (35%), Positives = 85/168 (50%), Gaps = 8/168 (4%)

Query: 122 GTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKK-KSCPNPGEIRNGQIDVP-GG 179
           GTV+ Y+C PGY  E   S  LTC  +L WS A   C+K  +C +PGEI NG       G
Sbjct: 595 GTVLTYQCEPGY--ELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAG 652

Query: 180 ILFGATISFSCNTGYKLFGSTSSFCLISGSSV-QWSDPLPECREIY--CPAPPQIDNGII 236
              G+ + + C  GY L G+    C    +   +WSD +P+C   Y  C  P   +NG  
Sbjct: 653 FPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQ 712

Query: 237 QGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECR 284
              + HY   +S+ + C +GF +IGE +I C V     +W+  PP C+
Sbjct: 713 TLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 759



 Score = 65.9 bits (159), Expect = 6e-11
 Identities = 55/186 (29%), Positives = 79/186 (42%), Gaps = 18/186 (9%)

Query: 59  TVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNR--SCEVPTRLNSASLKQPYITQ 116
           TV+TY+CE  +  +    D + C     WS     C +  +C  P  + +        + 
Sbjct: 596 TVLTYQCEPGYELLGS--DILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTA---SD 650

Query: 117 NYFPVGTVVEYECRPGYRREPSLSPKLTCLQ----NLKWSTAVEFC--KKKSCPNPGEIR 170
             FPVG+ V+Y C PGY  E   +  LTC        KWS  V  C  K + C NPG   
Sbjct: 651 AGFPVGSHVQYRCLPGYSLEG--AAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPE 708

Query: 171 NG-QIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPP 229
           NG Q         G ++ F C  G++L G  +  C + G   QW+   P C+      P 
Sbjct: 709 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCKVTQTTDPS 767

Query: 230 -QIDNG 234
            Q++ G
Sbjct: 768 RQLEGG 773



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 31/109 (28%), Positives = 49/109 (44%), Gaps = 7/109 (6%)

Query: 178 GGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIY-CPAPPQIDNGII 236
           G ++ G  +++ C  GY+L GS    C      + WS   P C++I  C  P +I NG  
Sbjct: 590 GDLIRGTVLTYQCEPGYELLGSDILTC---QWDLSWSAAPPACQKIMTCADPGEIANGHR 646

Query: 237 QGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEG--EWSGPPPEC 283
                 +     V Y C  G+++ G   + C  + D G  +WS   P+C
Sbjct: 647 TASDAGFPVGSHVQYRCLPGYSLEGAAMLTC-YSRDTGTPKWSDRVPKC 694



 Score = 36.2 bits (82), Expect = 0.050
 Identities = 21/63 (33%), Positives = 31/63 (49%), Gaps = 10/63 (15%)

Query: 162 SCPNPGEIRNGQIDV----PGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPL 217
           SC  P    +G + V    PGG     T +F C++GY+L G  +  CL +G+   W+   
Sbjct: 219 SCGFPPRPAHGDVSVTDLHPGG-----TATFHCDSGYQLQGEETLICL-NGTRPSWNGET 272

Query: 218 PEC 220
           P C
Sbjct: 273 PSC 275


>gi|166235136 seizure related 6 homolog (mouse)-like 2 isoform 2
           [Homo sapiens]
          Length = 910

 Score = 97.1 bits (240), Expect = 2e-20
 Identities = 60/168 (35%), Positives = 85/168 (50%), Gaps = 8/168 (4%)

Query: 122 GTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKK-KSCPNPGEIRNGQIDVP-GG 179
           GTV+ Y+C PGY  E   S  LTC  +L WS A   C+K  +C +PGEI NG       G
Sbjct: 665 GTVLTYQCEPGY--ELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAG 722

Query: 180 ILFGATISFSCNTGYKLFGSTSSFCLISGSSV-QWSDPLPECREIY--CPAPPQIDNGII 236
              G+ + + C  GY L G+    C    +   +WSD +P+C   Y  C  P   +NG  
Sbjct: 723 FPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQ 782

Query: 237 QGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECR 284
              + HY   +S+ + C +GF +IGE +I C V     +W+  PP C+
Sbjct: 783 TLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 829



 Score = 65.9 bits (159), Expect = 6e-11
 Identities = 55/186 (29%), Positives = 79/186 (42%), Gaps = 18/186 (9%)

Query: 59  TVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNR--SCEVPTRLNSASLKQPYITQ 116
           TV+TY+CE  +  +    D + C     WS     C +  +C  P  + +        + 
Sbjct: 666 TVLTYQCEPGYELLGS--DILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTA---SD 720

Query: 117 NYFPVGTVVEYECRPGYRREPSLSPKLTCLQ----NLKWSTAVEFC--KKKSCPNPGEIR 170
             FPVG+ V+Y C PGY  E   +  LTC        KWS  V  C  K + C NPG   
Sbjct: 721 AGFPVGSHVQYRCLPGYSLEG--AAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPE 778

Query: 171 NG-QIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPP 229
           NG Q         G ++ F C  G++L G  +  C + G   QW+   P C+      P 
Sbjct: 779 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCKVTQTTDPS 837

Query: 230 -QIDNG 234
            Q++ G
Sbjct: 838 RQLEGG 843



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 31/109 (28%), Positives = 49/109 (44%), Gaps = 7/109 (6%)

Query: 178 GGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIY-CPAPPQIDNGII 236
           G ++ G  +++ C  GY+L GS    C      + WS   P C++I  C  P +I NG  
Sbjct: 660 GDLIRGTVLTYQCEPGYELLGSDILTC---QWDLSWSAAPPACQKIMTCADPGEIANGHR 716

Query: 237 QGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEG--EWSGPPPEC 283
                 +     V Y C  G+++ G   + C  + D G  +WS   P+C
Sbjct: 717 TASDAGFPVGSHVQYRCLPGYSLEGAAMLTC-YSRDTGTPKWSDRVPKC 764



 Score = 36.2 bits (82), Expect = 0.050
 Identities = 21/63 (33%), Positives = 31/63 (49%), Gaps = 10/63 (15%)

Query: 162 SCPNPGEIRNGQIDV----PGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPL 217
           SC  P    +G + V    PGG     T +F C++GY+L G  +  CL +G+   W+   
Sbjct: 289 SCGFPPRPAHGDVSVTDLHPGG-----TATFHCDSGYQLQGEETLICL-NGTRPSWNGET 342

Query: 218 PEC 220
           P C
Sbjct: 343 PSC 345


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.134    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,401,672
Number of Sequences: 37866
Number of extensions: 983211
Number of successful extensions: 9569
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 121
Number of HSP's successfully gapped in prelim test: 118
Number of HSP's that attempted gapping in prelim test: 3998
Number of HSP's gapped (non-prelim): 2902
length of query: 381
length of database: 18,247,518
effective HSP length: 104
effective length of query: 277
effective length of database: 14,309,454
effective search space: 3963718758
effective search space used: 3963718758
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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