Guide to the Human Genome
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Search of human proteins with 239735592

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
         (1268 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa...  2543   0.0  
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa...  2536   0.0  
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa...  2528   0.0  
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa...  2521   0.0  
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa...  2498   0.0  
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa...  2490   0.0  
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa...  2482   0.0  
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap...  2475   0.0  
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]    1608   0.0  
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]     1587   0.0  
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]    1584   0.0  
gi|22035604 mitogen-activated protein kinase kinase kinase kinas...  1578   0.0  
gi|22035606 mitogen-activated protein kinase kinase kinase kinas...  1577   0.0  
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]    1572   0.0  
gi|22035602 mitogen-activated protein kinase kinase kinase kinas...  1536   0.0  
gi|118600963 Nik related kinase [Homo sapiens]                        400   e-111
gi|145275208 myosin IIIA [Homo sapiens]                               306   6e-83
gi|134288915 myosin IIIB isoform 1 [Homo sapiens]                     296   8e-80
gi|134288892 myosin IIIB isoform 2 [Homo sapiens]                     296   8e-80
gi|5454096 serine/threonine kinase 4 [Homo sapiens]                   273   8e-73
gi|15451902 mitogen-activated protein kinase kinase kinase kinas...   266   1e-70
gi|38570135 mitogen-activated protein kinase kinase kinase kinas...   263   8e-70
gi|14589909 mitogen-activated protein kinase kinase kinase kinas...   263   8e-70
gi|103471999 serine/threonine kinase 3 [Homo sapiens]                 260   5e-69
gi|21361358 serine/threonine kinase 25 [Homo sapiens]                 259   9e-69
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo...   259   1e-68
gi|41281453 serine/threonine kinase 2 [Homo sapiens]                  255   2e-67
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]      253   6e-67
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]       253   6e-67
gi|22035600 mitogen-activated protein kinase kinase kinase kinas...   249   9e-66

>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
            sapiens]
          Length = 1268

 Score = 2543 bits (6592), Expect = 0.0
 Identities = 1268/1268 (100%), Positives = 1268/1268 (100%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
            QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360

Query: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
            NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420

Query: 421  REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480
            REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE
Sbjct: 421  REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480

Query: 481  QRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQE 540
            QRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQE
Sbjct: 481  QRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQE 540

Query: 541  ALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALA 600
            ALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALA
Sbjct: 541  ALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALA 600

Query: 601  RKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQG 660
            RKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQG
Sbjct: 601  RKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQG 660

Query: 661  GSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELR 720
            GSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELR
Sbjct: 661  GSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELR 720

Query: 721  ELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSN 780
            ELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSN
Sbjct: 721  ELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSN 780

Query: 781  EQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDL 840
            EQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDL
Sbjct: 781  EQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDL 840

Query: 841  VQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEE 900
            VQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEE
Sbjct: 841  VQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEE 900

Query: 901  DEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILC 960
            DEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILC
Sbjct: 901  DEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILC 960

Query: 961  AALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRV 1020
            AALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRV
Sbjct: 961  AALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRV 1020

Query: 1021 YYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWA 1080
            YYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWA
Sbjct: 1021 YYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWA 1080

Query: 1081 PKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPS 1140
            PKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPS
Sbjct: 1081 PKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPS 1140

Query: 1141 HIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSN 1200
            HIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSN
Sbjct: 1141 HIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSN 1200

Query: 1201 QIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTL 1260
            QIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTL
Sbjct: 1201 QIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTL 1260

Query: 1261 NRNSMMNW 1268
            NRNSMMNW
Sbjct: 1261 NRNSMMNW 1268


>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
            sapiens]
          Length = 1276

 Score = 2536 bits (6573), Expect = 0.0
 Identities = 1268/1276 (99%), Positives = 1268/1276 (99%), Gaps = 8/1276 (0%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
            QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360

Query: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
            NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420

Query: 421  REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480
            REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE
Sbjct: 421  REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480

Query: 481  QRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQE 540
            QRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQE
Sbjct: 481  QRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQE 540

Query: 541  ALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALA 600
            ALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALA
Sbjct: 541  ALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALA 600

Query: 601  RKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQG 660
            RKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQG
Sbjct: 601  RKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQG 660

Query: 661  GSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA--------DL 712
            GSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA        DL
Sbjct: 661  GSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDL 720

Query: 713  TALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLI 772
            TALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLI
Sbjct: 721  TALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLI 780

Query: 773  PTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFA 832
            PTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFA
Sbjct: 781  PTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFA 840

Query: 833  GHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQT 892
            GHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQT
Sbjct: 841  GHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQT 900

Query: 893  SPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKK 952
            SPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKK
Sbjct: 901  SPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKK 960

Query: 953  RFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTIS 1012
            RFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTIS
Sbjct: 961  RFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTIS 1020

Query: 1013 GKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKN 1072
            GKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKN
Sbjct: 1021 GKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKN 1080

Query: 1073 AVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGN 1132
            AVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGN
Sbjct: 1081 AVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGN 1140

Query: 1133 SYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPT 1192
            SYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPT
Sbjct: 1141 SYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPT 1200

Query: 1193 SVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS 1252
            SVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS
Sbjct: 1201 SVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS 1260

Query: 1253 SQVFFMTLNRNSMMNW 1268
            SQVFFMTLNRNSMMNW
Sbjct: 1261 SQVFFMTLNRNSMMNW 1276


>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
            sapiens]
          Length = 1297

 Score = 2528 bits (6552), Expect = 0.0
 Identities = 1268/1297 (97%), Positives = 1268/1297 (97%), Gaps = 29/1297 (2%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
            QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360

Query: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
            NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420

Query: 421  REQRRHYEEQMRREEERRRAEHEQEY-----------------------------KRKQL 451
            REQRRHYEEQMRREEERRRAEHEQEY                             KRKQL
Sbjct: 421  REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480

Query: 452  EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHL 511
            EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHL
Sbjct: 481  EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHL 540

Query: 512  VAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEK 571
            VAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEK
Sbjct: 541  VAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEK 600

Query: 572  FDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTE 631
            FDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTE
Sbjct: 601  FDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTE 660

Query: 632  PILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHE 691
            PILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHE
Sbjct: 661  PILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHE 720

Query: 692  PAKVKPEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEE 751
            PAKVKPEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEE
Sbjct: 721  PAKVKPEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEE 780

Query: 752  EDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTL 811
            EDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTL
Sbjct: 781  EDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTL 840

Query: 812  MIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEY 871
            MIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEY
Sbjct: 841  MIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEY 900

Query: 872  GMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVV 931
            GMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVV
Sbjct: 901  GMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVV 960

Query: 932  NVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLI 991
            NVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLI
Sbjct: 961  NVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLI 1020

Query: 992  NRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEG 1051
            NRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEG
Sbjct: 1021 NRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEG 1080

Query: 1052 CIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQ 1111
            CIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQ
Sbjct: 1081 CIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQ 1140

Query: 1112 RLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGV 1171
            RLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGV
Sbjct: 1141 RLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGV 1200

Query: 1172 YVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQR 1231
            YVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQR
Sbjct: 1201 YVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQR 1260

Query: 1232 LKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1268
            LKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Sbjct: 1261 LKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1297


>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
            sapiens]
          Length = 1305

 Score = 2521 bits (6533), Expect = 0.0
 Identities = 1268/1305 (97%), Positives = 1268/1305 (97%), Gaps = 37/1305 (2%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
            QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360

Query: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
            NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420

Query: 421  REQRRHYEEQMRREEERRRAEHEQEY-----------------------------KRKQL 451
            REQRRHYEEQMRREEERRRAEHEQEY                             KRKQL
Sbjct: 421  REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480

Query: 452  EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHL 511
            EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHL
Sbjct: 481  EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHL 540

Query: 512  VAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEK 571
            VAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEK
Sbjct: 541  VAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEK 600

Query: 572  FDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTE 631
            FDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTE
Sbjct: 601  FDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTE 660

Query: 632  PILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHE 691
            PILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHE
Sbjct: 661  PILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHE 720

Query: 692  PAKVKPEESRDITRPSRPA--------DLTALAKELRELRIEETNRPMKKVTDYSSSSEE 743
            PAKVKPEESRDITRPSRPA        DLTALAKELRELRIEETNRPMKKVTDYSSSSEE
Sbjct: 721  PAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEE 780

Query: 744  SESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSG 803
            SESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSG
Sbjct: 781  SESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSG 840

Query: 804  SISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQ 863
            SISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQ
Sbjct: 841  SISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQ 900

Query: 864  EMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLN 923
            EMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLN
Sbjct: 901  EMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLN 960

Query: 924  EARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSG 983
            EARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSG
Sbjct: 961  EARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSG 1020

Query: 984  QGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGW 1043
            QGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGW
Sbjct: 1021 QGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGW 1080

Query: 1044 ITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLV 1103
            ITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLV
Sbjct: 1081 ITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLV 1140

Query: 1104 DLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEML 1163
            DLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEML
Sbjct: 1141 DLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEML 1200

Query: 1164 VCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGV 1223
            VCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGV
Sbjct: 1201 VCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGV 1260

Query: 1224 FMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1268
            FMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Sbjct: 1261 FMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1305


>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
            sapiens]
          Length = 1323

 Score = 2498 bits (6473), Expect = 0.0
 Identities = 1260/1323 (95%), Positives = 1263/1323 (95%), Gaps = 55/1323 (4%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
            QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360

Query: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
            NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420

Query: 421  REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480
            REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE
Sbjct: 421  REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480

Query: 481  QRPVEKKPLYHYKEGMS------------------------------------------- 497
            QRPVEKKPLYHYKEGMS                                           
Sbjct: 481  QRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSE 540

Query: 498  --------PSEKPAWAK----EIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT 545
                    P+  P   +    +IPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT
Sbjct: 541  SFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT 600

Query: 546  SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 605
            SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP
Sbjct: 601  SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 660

Query: 606  GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG 665
            GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG
Sbjct: 661  GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG 720

Query: 666  SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELRELRIE 725
            SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELRELRIE
Sbjct: 721  SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELRELRIE 780

Query: 726  ETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNV 785
            ETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNV
Sbjct: 781  ETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNV 840

Query: 786  GMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSH 845
            GMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSH
Sbjct: 841  GMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSH 900

Query: 846  SPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESS 905
            SPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESS
Sbjct: 901  SPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESS 960

Query: 906  AAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWG 965
            AAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWG
Sbjct: 961  AAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWG 1020

Query: 966  VNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSW 1025
            VNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSW
Sbjct: 1021 VNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSW 1080

Query: 1026 LRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYH 1085
            LRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYH
Sbjct: 1081 LRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYH 1140

Query: 1086 KFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGN 1145
            KFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGN
Sbjct: 1141 KFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGN 1200

Query: 1146 ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGW 1205
            ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGW
Sbjct: 1201 ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGW 1260

Query: 1206 GEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSM 1265
            GEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSM
Sbjct: 1261 GEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSM 1320

Query: 1266 MNW 1268
            MNW
Sbjct: 1321 MNW 1323


>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
            sapiens]
          Length = 1331

 Score = 2490 bits (6454), Expect = 0.0
 Identities = 1260/1331 (94%), Positives = 1263/1331 (94%), Gaps = 63/1331 (4%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
            QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360

Query: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
            NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420

Query: 421  REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480
            REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE
Sbjct: 421  REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480

Query: 481  QRPVEKKPLYHYKEGMS------------------------------------------- 497
            QRPVEKKPLYHYKEGMS                                           
Sbjct: 481  QRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSE 540

Query: 498  --------PSEKPAWAK----EIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT 545
                    P+  P   +    +IPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT
Sbjct: 541  SFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT 600

Query: 546  SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 605
            SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP
Sbjct: 601  SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 660

Query: 606  GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG 665
            GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG
Sbjct: 661  GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG 720

Query: 666  SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA--------DLTALAK 717
            SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA        DLTALAK
Sbjct: 721  SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAK 780

Query: 718  ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP 777
            ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP
Sbjct: 781  ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP 840

Query: 778  GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINL 837
            GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINL
Sbjct: 841  GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINL 900

Query: 838  PDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDE 897
            PDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDE
Sbjct: 901  PDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDE 960

Query: 898  DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE 957
            DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE
Sbjct: 961  DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE 1020

Query: 958  ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK 1017
            ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK
Sbjct: 1021 ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK 1080

Query: 1018 LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY 1077
            LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY
Sbjct: 1081 LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY 1140

Query: 1078 AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY 1137
            AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY
Sbjct: 1141 AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY 1200

Query: 1138 IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI 1197
            IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI
Sbjct: 1201 IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI 1260

Query: 1198 HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF 1257
            HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF
Sbjct: 1261 HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF 1320

Query: 1258 MTLNRNSMMNW 1268
            MTLNRNSMMNW
Sbjct: 1321 MTLNRNSMMNW 1331


>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
            sapiens]
          Length = 1352

 Score = 2482 bits (6433), Expect = 0.0
 Identities = 1260/1352 (93%), Positives = 1263/1352 (93%), Gaps = 84/1352 (6%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
            QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360

Query: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
            NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420

Query: 421  REQRRHYEEQMRREEERRRAEHEQEY-----------------------------KRKQL 451
            REQRRHYEEQMRREEERRRAEHEQEY                             KRKQL
Sbjct: 421  REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480

Query: 452  EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMS-------------- 497
            EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMS              
Sbjct: 481  EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 540

Query: 498  -------------------------------------PSEKPAWAK----EIPHLVAVKS 516
                                                 P+  P   +    +IPHLVAVKS
Sbjct: 541  SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 600

Query: 517  QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 576
            QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS
Sbjct: 601  QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 660

Query: 577  WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 636
            WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES
Sbjct: 661  WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 720

Query: 637  PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 696
            PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK
Sbjct: 721  PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 780

Query: 697  PEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGES 756
            PEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGES
Sbjct: 781  PEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGES 840

Query: 757  ETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET 816
            ETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET
Sbjct: 841  ETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET 900

Query: 817  SGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSS 876
            SGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSS
Sbjct: 901  SGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSS 960

Query: 877  TKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPT 936
            TKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPT
Sbjct: 961  TKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPT 1020

Query: 937  NIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRF 996
            NIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRF
Sbjct: 1021 NIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRF 1080

Query: 997  QQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYK 1056
            QQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYK
Sbjct: 1081 QQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYK 1140

Query: 1057 VVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVI 1116
            VVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVI
Sbjct: 1141 VVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVI 1200

Query: 1117 FGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTY 1176
            FGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTY
Sbjct: 1201 FGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTY 1260

Query: 1177 GRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC 1236
            GRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC
Sbjct: 1261 GRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC 1320

Query: 1237 ERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1268
            ERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Sbjct: 1321 ERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1352


>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sapiens]
          Length = 1360

 Score = 2475 bits (6414), Expect = 0.0
 Identities = 1260/1360 (92%), Positives = 1263/1360 (92%), Gaps = 92/1360 (6%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
            QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360

Query: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
            NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420

Query: 421  REQRRHYEEQMRREEERRRAEHEQEY-----------------------------KRKQL 451
            REQRRHYEEQMRREEERRRAEHEQEY                             KRKQL
Sbjct: 421  REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480

Query: 452  EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMS-------------- 497
            EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMS              
Sbjct: 481  EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 540

Query: 498  -------------------------------------PSEKPAWAK----EIPHLVAVKS 516
                                                 P+  P   +    +IPHLVAVKS
Sbjct: 541  SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 600

Query: 517  QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 576
            QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS
Sbjct: 601  QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 660

Query: 577  WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 636
            WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES
Sbjct: 661  WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 720

Query: 637  PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 696
            PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK
Sbjct: 721  PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 780

Query: 697  PEESRDITRPSRPA--------DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE 748
            PEESRDITRPSRPA        DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE
Sbjct: 781  PEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE 840

Query: 749  EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE 808
            EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE
Sbjct: 841  EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE 900

Query: 809  GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 868
            GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG
Sbjct: 901  GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 960

Query: 869  TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI 928
            TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI
Sbjct: 961  TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI 1020

Query: 929  SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY 988
            SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY
Sbjct: 1021 SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY 1080

Query: 989  NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD 1048
            NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD
Sbjct: 1081 NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD 1140

Query: 1049 LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE 1108
            LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE
Sbjct: 1141 LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE 1200

Query: 1109 EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED 1168
            EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED
Sbjct: 1201 EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED 1260

Query: 1169 EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR 1228
            EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR
Sbjct: 1261 EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR 1320

Query: 1229 AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1268
            AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Sbjct: 1321 AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1360


>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
          Length = 1312

 Score = 1608 bits (4163), Expect = 0.0
 Identities = 877/1369 (64%), Positives = 1004/1369 (73%), Gaps = 158/1369 (11%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            M   +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT 
Sbjct: 1    MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNP PRLKSKKWSKKF  FI++CL+K +  RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241  ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
            QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ 
Sbjct: 301  QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360

Query: 360  ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
             NK  SEAL++QQ   +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 361  ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420

Query: 418  QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
             QE+EQ+R  E+   +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE  YL SLQ
Sbjct: 421  LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480

Query: 476  HQRQEQR----------PVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQ-------- 517
             Q+Q+Q+          P ++KPLYHY  GM+P++KPAWA+E+     +  Q        
Sbjct: 481  QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540

Query: 518  ----------------GPALTASQ----------------SVHEQPTKGLSGFQEALN-- 543
                            GP    SQ                S+ +QPT+ L+ F  + +  
Sbjct: 541  KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLQDQPTRNLAAFPASHDPD 600

Query: 544  --------VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDRSSWLRQEEDIPPKVPQRTTS 594
                      S R  + RQNSDPTSE P P P      +  +W+R + + PPKVPQRT+S
Sbjct: 601  PAIPAPTATPSARGAVIRQNSDPTSEGPGPSP------NPPAWVRPDNEAPPKVPQRTSS 654

Query: 595  ISPALARKNSPGNGSALG----PRLGSQ--------------------------PIRASN 624
            I+ AL    + G+  A      PR  S                           P  +SN
Sbjct: 655  IATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSN 714

Query: 625  PDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEG 684
            PDLRR++P  E           S S  P+S      G  P  QAGS ER RV  +SK + 
Sbjct: 715  PDLRRSDPGWER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDS 757

Query: 685  SPVLPHEPAKVKPEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEES 744
            SPVL     K KP++ R  +RP RPAD   L    +E  ++E  RP KK  DYSSSSEE 
Sbjct: 758  SPVLS-PGNKAKPDDHR--SRPGRPADFVLL----KERTLDEAPRPPKKAMDYSSSSEEV 810

Query: 745  ESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSFS 802
            ESSE++EE+GE    +G+    D P     G     +  +V  +  H +E  T     + 
Sbjct: 811  ESSEDDEEEGEGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPYG 862

Query: 803  GSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHS 862
            G     GT++++ T  E++   H+DSNG+    NLPD+VQ SHSP    TE     S  S
Sbjct: 863  G-----GTMVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPPS 910

Query: 863  QEMDSGTEYGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQ 919
            ++  SG     G   +  K+SFT FVD  +YQ   + +          AL   E  R +Q
Sbjct: 911  KD-GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLDQ 964

Query: 920  AKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLL 979
             +  + RK SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLL
Sbjct: 965  LQY-DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLL 1023

Query: 980  DRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEK 1039
            DRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVEK
Sbjct: 1024 DRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEK 1083

Query: 1040 KQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHK 1099
            KQGW TVGD+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H+
Sbjct: 1084 KQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHR 1143

Query: 1100 PLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDG 1159
            PLLVDLTVEEGQRLKVI+GS  GFH +DVDSGNSYDIYIP HIQ  ITPHAI+ LP TDG
Sbjct: 1144 PLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDG 1203

Query: 1160 MEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGH 1219
            MEML+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETGH
Sbjct: 1204 MEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGH 1263

Query: 1220 LDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1268
            LDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1264 LDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1312


>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
          Length = 1295

 Score = 1587 bits (4108), Expect = 0.0
 Identities = 872/1359 (64%), Positives = 997/1359 (73%), Gaps = 155/1359 (11%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            M   +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT 
Sbjct: 1    MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNP PRLKSKKWSKKF  FI++CL+K +  RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241  ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
            QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ 
Sbjct: 301  QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360

Query: 360  ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
             NK  SEAL++QQ   +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 361  ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420

Query: 418  QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
             QE+EQ+R  E+   +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE  YL SLQ
Sbjct: 421  LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480

Query: 476  HQ-------RQEQ---------------------------RPVEKK---------PLYHY 492
             Q       +Q+Q                           R VE++         PL   
Sbjct: 481  QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540

Query: 493  KEGMS---------------------PSEKPAWAKEIPHL------VAVKSQGPALTASQ 525
            K G +                     P ++P   +E PH       V +K     +  SQ
Sbjct: 541  KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600

Query: 526  SVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDR 574
            S+ +QPT+ L+ F  + +            S R  + RQNSDPTSE P P P      + 
Sbjct: 601  SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP------NP 654

Query: 575  SSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPIL 634
             +W+R + + PPKVPQRT+SI+ AL       N S  G    +Q +RASNPDLRR++P  
Sbjct: 655  PAWVRPDNEAPPKVPQRTSSIATAL-------NTSGAGGSRPAQAVRASNPDLRRSDPGW 707

Query: 635  ESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAK 694
            E           S S  P+S      G  P  QAGS ER RV  +SK + SPVL     K
Sbjct: 708  ER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDSSPVLS-PGNK 749

Query: 695  VKPEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDG 754
             KP++ R  +RP RPAD   L    +E  ++E  RP KK  DYSSSSEE ESSE++EE+G
Sbjct: 750  AKPDDHR--SRPGRPADFVLL----KERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG 803

Query: 755  ESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSFSGSISREGTLM 812
            E    +G+    D P     G     +  +V  +  H +E  T     + G     GT++
Sbjct: 804  EGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPYGG-----GTMV 850

Query: 813  IRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYG 872
            ++ T  E++   H+DSNG+    NLPD+VQ SHSP    TE     S  S++  SG    
Sbjct: 851  VQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPPSKD-GSGDYQS 902

Query: 873  MG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKIS 929
             G   +  K+SFT FVD  +YQ   + +          AL   E  R +Q +  + RK S
Sbjct: 903  RGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLDQLQY-DVRKGS 956

Query: 930  VVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYN 989
            VVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY 
Sbjct: 957  VVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYG 1016

Query: 990  LINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDL 1049
            LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVEKKQGW TVGD+
Sbjct: 1017 LIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDM 1076

Query: 1050 EGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEE 1109
            EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H+PLLVDLTVEE
Sbjct: 1077 EGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEE 1136

Query: 1110 GQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDE 1169
            GQRLKVI+GS  GFH +DVDSGNSYDIYIP HIQ  ITPHAI+ LP TDGMEML+CYEDE
Sbjct: 1137 GQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDE 1196

Query: 1170 GVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRA 1229
            GVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETGHLDGVFMHKRA
Sbjct: 1197 GVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRA 1256

Query: 1230 QRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1268
            QRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1257 QRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1295


>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
          Length = 1303

 Score = 1584 bits (4101), Expect = 0.0
 Identities = 872/1363 (63%), Positives = 997/1363 (73%), Gaps = 155/1363 (11%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            M   +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT 
Sbjct: 1    MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNP PRLKSKKWSKKF  FI++CL+K +  RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241  ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
            QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ 
Sbjct: 301  QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360

Query: 360  ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
             NK  SEAL++QQ   +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 361  ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420

Query: 418  QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
             QE+EQ+R  E+   +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE  YL SLQ
Sbjct: 421  LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480

Query: 476  HQ-------RQEQ---------------------------RPVEKK---------PLYHY 492
             Q       +Q+Q                           R VE++         PL   
Sbjct: 481  QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540

Query: 493  KEGMS---------------------PSEKPAWAKEIPHL------VAVKSQGPALTASQ 525
            K G +                     P ++P   +E PH       V +K     +  SQ
Sbjct: 541  KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600

Query: 526  SVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDR 574
            S+ +QPT+ L+ F  + +            S R  + RQNSDPTSE P P P      + 
Sbjct: 601  SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP------NP 654

Query: 575  SSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPIL 634
             +W+R + + PPKVPQRT+SI+ AL       N S  G    +Q +RASNPDLRR++P  
Sbjct: 655  PAWVRPDNEAPPKVPQRTSSIATAL-------NTSGAGGSRPAQAVRASNPDLRRSDPGW 707

Query: 635  ESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAK 694
            E           S S  P+S      G  P  QAGS ER RV  +SK + SPVL     K
Sbjct: 708  ER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDSSPVLS-PGNK 749

Query: 695  VKPEESRDITRPSRPADLTALAKE----LRELRIEETNRPMKKVTDYSSSSEESESSEEE 750
             KP++ R  +RP RPA       E    L+E  ++E  RP KK  DYSSSSEE ESSE++
Sbjct: 750  AKPDDHR--SRPGRPASYKRAIGEDFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDD 807

Query: 751  EEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSFSGSISRE 808
            EE+GE    +G+    D P     G     +  +V  +  H +E  T     + G     
Sbjct: 808  EEEGEGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPYGG----- 854

Query: 809  GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 868
            GT++++ T  E++   H+DSNG+    NLPD+VQ SHSP    TE     S  S++  SG
Sbjct: 855  GTMVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPPSKD-GSG 906

Query: 869  TEYGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEA 925
                 G   +  K+SFT FVD  +YQ   + +          AL   E  R +Q +  + 
Sbjct: 907  DYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLDQLQY-DV 960

Query: 926  RKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQG 985
            RK SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQG
Sbjct: 961  RKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQG 1020

Query: 986  KVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWIT 1045
            KVY LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVEKKQGW T
Sbjct: 1021 KVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTT 1080

Query: 1046 VGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDL 1105
            VGD+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H+PLLVDL
Sbjct: 1081 VGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDL 1140

Query: 1106 TVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVC 1165
            TVEEGQRLKVI+GS  GFH +DVDSGNSYDIYIP HIQ  ITPHAI+ LP TDGMEML+C
Sbjct: 1141 TVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLC 1200

Query: 1166 YEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFM 1225
            YEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETGHLDGVFM
Sbjct: 1201 YEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFM 1260

Query: 1226 HKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1268
            HKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1261 HKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1303


>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
            isoform 2 [Homo sapiens]
          Length = 1320

 Score = 1578 bits (4087), Expect = 0.0
 Identities = 872/1384 (63%), Positives = 992/1384 (71%), Gaps = 180/1384 (13%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT 
Sbjct: 1    MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61   DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241  ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
            QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE     GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301  QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360

Query: 359  LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
              NKERSEALRRQQL  EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 361  QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420

Query: 417  KQQEREQRRHYEEQMRR-----------------EEERRRAEHEQEYKRKQLEEQ----- 454
            +QQEREQRR  +E+ RR                 EEE+RR E EQEY R+QLEE+     
Sbjct: 421  RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480

Query: 455  ------------------------RQAERLQRQLKQERDYLVSLQHQRQEQRP------- 483
                                    RQAERLQRQL+QE+ YL+SLQH  +   P       
Sbjct: 481  VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540

Query: 484  ----VEKKPLYHYKEGMSPSEKPAWAKEIPHL-----------------------VAVKS 516
                   KP +H  E  +  E    A+E+                          V  +S
Sbjct: 541  PPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRS 600

Query: 517  QGPALTASQSVH---EQPTKGLSGFQEALNVTSHRVEMPRQN--SDPT---------SEN 562
            +  +   S+SVH   ++P +    +    ++ ++   + R +  SDP+         S++
Sbjct: 601  ESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQD 660

Query: 563  PPLPTRIEKFDRSS-------------WLRQEED-IPPKVPQRTTSISPALARKNSPGNG 608
            P  P+R E   +SS             W R + D +PP+VP RTTS SP L+R++SP  G
Sbjct: 661  PCPPSRSEVLSQSSDSKSEAPDPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRDSPLQG 720

Query: 609  SALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQA 668
            S        Q    S+ + R     +E  + R  SGSSS SS   SQP    GS PGSQ+
Sbjct: 721  SGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP----GSHPGSQS 776

Query: 669  GSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA---DLTALAKELRELRIE 725
            GS ER RVR++SKSEGSP    E A  KPE+ +++ RP +PA   DLTALAKELR +   
Sbjct: 777  GSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAV--- 833

Query: 726  ETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNV 785
            E  RP  KVTDYSSSSEES +++EE++D E E  D + +  +  R   +    + E  +V
Sbjct: 834  EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESV 893

Query: 786  GMVGTHGLETSHADSFSGSISREGTLMIRET-SGEKKRSGHSDSNGFAGHINLPDLVQQS 844
              +  H    S     + + S+EGTL++R+T S       H  S+ F   I+ P L+Q S
Sbjct: 894  KTMIVHDDVESEP---AMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFID-PRLLQIS 949

Query: 845  HSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEES 904
             S   T T  +G                                                
Sbjct: 950  PSSGTTVTSVVG------------------------------------------------ 961

Query: 905  SAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALW 964
                 F+ + +R E  + +  RK SVVNVNPTN RP SDTPEIRKYKKRFNSEILCAALW
Sbjct: 962  -----FSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALW 1016

Query: 965  GVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLS 1024
            GVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLEGLNVLVTISGKK+KLRVYYLS
Sbjct: 1017 GVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLS 1076

Query: 1025 WLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPY 1084
            WLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERIKFLVIALK++VE+YAWAPKPY
Sbjct: 1077 WLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPY 1136

Query: 1085 HKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQG 1144
            HKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS  GFH +DVDSG+ YDIY+P+HIQ 
Sbjct: 1137 HKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQC 1196

Query: 1145 NITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMG 1204
            +I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI SNQ MG
Sbjct: 1197 SIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMG 1256

Query: 1205 WGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNS 1264
            WGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTL R S
Sbjct: 1257 WGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTS 1316

Query: 1265 MMNW 1268
            +++W
Sbjct: 1317 LLSW 1320


>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
            isoform 3 [Homo sapiens]
          Length = 1212

 Score = 1577 bits (4084), Expect = 0.0
 Identities = 853/1285 (66%), Positives = 964/1285 (75%), Gaps = 90/1285 (7%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT 
Sbjct: 1    MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61   DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241  ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
            QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE     GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301  QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360

Query: 359  LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
              NKERSEALRRQQL  EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 361  QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420

Query: 417  KQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAER----LQRQLKQERDYLV 472
            +QQEREQRR  +E+ RR EE  R   E+E +R+  EE+R+ ER    ++RQL++E+ +L 
Sbjct: 421  RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480

Query: 473  SLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPT 532
             LQ Q  +++ +    L H      P      +++ P     +S+          H +P 
Sbjct: 481  VLQQQLLQEQAM----LLHDHRRPHPQH----SQQPPPPQQERSKPSFHAPEPKAHYEPA 532

Query: 533  KGLSGFQEALNVTSHRVEMPRQNSDPTSE--NPPLPTRIEKFDR----SSWLRQEEDIPP 586
                  ++    T+H    P   S  T     PP+P+R E F      S     +    P
Sbjct: 533  DRAREVEDRFRKTNH--SSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEP 590

Query: 587  KVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSS 646
            +VP RTTS SP L+R++SP  GS        Q    S+ + R     +E  + R  SGSS
Sbjct: 591  QVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSS 650

Query: 647  SSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRP 706
            S SS   SQP    GS PGSQ+GS ER RVR++SKSEGSP    E A  KPE+ +++ RP
Sbjct: 651  SGSSNSGSQP----GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRP 706

Query: 707  SRPA---DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTV 763
             +PA   DLTALAKELR +   E  RP  KVTDYSSSSEES +++EE++D E E      
Sbjct: 707  LKPAGEVDLTALAKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQE------ 757

Query: 764  AVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRS 823
                          G++E        T G E + A S          L   ET   K   
Sbjct: 758  --------------GADES-------TSGPEDTRAASSLN-------LSNGETESVKTMI 789

Query: 824  GHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTP 883
             H D                   PA TP++    +   +Q   S  +    SS   SFTP
Sbjct: 790  VHDDVES---------------EPAMTPSKEGTLIVRQTQSASSTLQKHKSSS---SFTP 831

Query: 884  FVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSD 943
            F+DPR+ Q SP+         ++   F+ + +R E  + +  RK SVVNVNPTN RP SD
Sbjct: 832  FIDPRLLQISPSS----GTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSD 887

Query: 944  TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLE 1003
            TPEIRKYKKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLE
Sbjct: 888  TPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLE 947

Query: 1004 GLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERI 1063
            GLNVLVTISGKK+KLRVYYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERI
Sbjct: 948  GLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERI 1007

Query: 1064 KFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGF 1123
            KFLVIALK++VE+YAWAPKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS  GF
Sbjct: 1008 KFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGF 1067

Query: 1124 HVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDV 1183
            H +DVDSG+ YDIY+P+HIQ +I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRITKDV
Sbjct: 1068 HAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDV 1127

Query: 1184 VLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVF 1243
            VLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVF
Sbjct: 1128 VLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVF 1187

Query: 1244 FASVRSGGSSQVFFMTLNRNSMMNW 1268
            FASVRSGGSSQV+FMTL R S+++W
Sbjct: 1188 FASVRSGGSSQVYFMTLGRTSLLSW 1212


>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
          Length = 1332

 Score = 1572 bits (4070), Expect = 0.0
 Identities = 872/1389 (62%), Positives = 998/1389 (71%), Gaps = 178/1389 (12%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            M   +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT 
Sbjct: 1    MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNP PRLKSKKWSKKF  FI++CL+K +  RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241  ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
            QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ 
Sbjct: 301  QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360

Query: 360  ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
             NK  SEAL++QQ   +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 361  ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420

Query: 418  QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
             QE+EQ+R  E+   +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE  YL SLQ
Sbjct: 421  LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480

Query: 476  HQ-------RQEQ---------------------------RPVEKK---------PLYHY 492
             Q       +Q+Q                           R VE++         PL   
Sbjct: 481  QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540

Query: 493  KEGMS---------------------PSEKPAWAKEIPHL------VAVKSQGPALTASQ 525
            K G +                     P ++P   +E PH       V +K     +  SQ
Sbjct: 541  KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600

Query: 526  SVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDR 574
            S+ +QPT+ L+ F  + +            S R  + RQNSDPTSE P P P      + 
Sbjct: 601  SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP------NP 654

Query: 575  SSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALG----PRLGSQ------------ 618
             +W+R + + PPKVPQRT+SI+ AL    + G+  A      PR  S             
Sbjct: 655  PAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERG 714

Query: 619  --------------PIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQP 664
                          P  +SNPDLRR++P  E           S S  P+S      G  P
Sbjct: 715  TPKPPGPPAQPPGPPNASSNPDLRRSDPGWER----------SDSVLPASH-----GHLP 759

Query: 665  GSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELRELRI 724
              QAGS ER RV  +SK + SPVL     K KP++ R  +RP RPAD   L    +E  +
Sbjct: 760  --QAGSLERNRVGVSSKPDSSPVLS-PGNKAKPDDHR--SRPGRPADFVLL----KERTL 810

Query: 725  EETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYN 784
            +E  RP KK  DYSSSSEE ESSE++EE+GE    +G+    D P     G     +  +
Sbjct: 811  DEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGS---RDTP-----GGRSDGDTDS 862

Query: 785  VGMVGTHGLE--TSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQ 842
            V  +  H +E  T     + G     GT++++ T  E++   H+DSNG+    NLPD+VQ
Sbjct: 863  VSTMVVHDVEEITGTQPPYGG-----GTMVVQRTPEEERNLLHADSNGYT---NLPDVVQ 914

Query: 843  QSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMG---SSTKASFTPFVDPRVYQTSPTDEDE 899
             SHSP    TE     S  S++  SG     G   +  K+SFT FVD  +YQ   + +  
Sbjct: 915  PSHSP----TENSKGQSPPSKD-GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS- 968

Query: 900  EDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEIL 959
                    AL   E  R +Q +  + RK SVVNVNPTN R HS+TPEIRKYKKRFNSEIL
Sbjct: 969  ----IPITALVGGEGTRLDQLQY-DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEIL 1023

Query: 960  CAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLR 1019
            CAALWGVNLLVGTENGLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK+NKLR
Sbjct: 1024 CAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLR 1083

Query: 1020 VYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAW 1079
            VYYLSWLRN+ILHNDPEVEKKQGW TVGD+EGC HY+VVKYERIKFLVIALK++VE+YAW
Sbjct: 1084 VYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAW 1143

Query: 1080 APKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIP 1139
            APKPYHKFMAFKSFADL H+PLLVDLTVEEGQRLKVI+GS  GFH +DVDSGNSYDIYIP
Sbjct: 1144 APKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIP 1203

Query: 1140 SHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHS 1199
             HIQ  ITPHAI+ LP TDGMEML+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI S
Sbjct: 1204 VHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICS 1263

Query: 1200 NQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMT 1259
            NQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMT
Sbjct: 1264 NQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMT 1323

Query: 1260 LNRNSMMNW 1268
            LNRN +MNW
Sbjct: 1324 LNRNCIMNW 1332


>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
            isoform 1 [Homo sapiens]
          Length = 1166

 Score = 1536 bits (3978), Expect = 0.0
 Identities = 837/1288 (64%), Positives = 946/1288 (73%), Gaps = 142/1288 (11%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT 
Sbjct: 1    MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61   DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241  ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
            QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE     GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301  QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360

Query: 359  LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
              NKERSEALRRQQL  EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 361  QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420

Query: 417  KQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAER----LQRQLKQERDYLV 472
            +QQEREQRR  +E+ RR EE  R   E+E +R+  EE+R+ ER    ++RQL++E+ +L 
Sbjct: 421  RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480

Query: 473  SLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPT 532
             LQ Q  +++ +    L H      P                              +QP 
Sbjct: 481  VLQQQLLQEQAM----LLHDHRRPHPQHS---------------------------QQPP 509

Query: 533  KGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRT 592
                                ++ S P+   P      E  DR+           +VP RT
Sbjct: 510  PP-----------------QQERSKPSFHAPEPKAHYEPADRAR----------EVPVRT 542

Query: 593  TSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTP 652
            TS SP L+R++SP  GS        Q    S+ + R     +E  + R  SGSSS SS  
Sbjct: 543  TSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNS 602

Query: 653  SSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA-- 710
             SQP    GS PGSQ+GS ER RVR++SKSEGSP    E A  KPE+ +++ RP +PA  
Sbjct: 603  GSQP----GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGE 658

Query: 711  -DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIP 769
             DLTALAKELR +   E  RP  KVTDYSSSSEES +++EE++D E E  D + +  +  
Sbjct: 659  VDLTALAKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDT 715

Query: 770  RLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET-SGEKKRSGHSDS 828
            R   +    + E  +V  +  H    S     + + S+EGTL++R+T S       H  S
Sbjct: 716  RAASSLNLSNGETESVKTMIVHDDVESEP---AMTPSKEGTLIVRQTQSASSTLQKHKSS 772

Query: 829  NGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPR 888
            + F   I+ P L+Q S S   T T  +G                                
Sbjct: 773  SSFTPFID-PRLLQISPSSGTTVTSVVG-------------------------------- 799

Query: 889  VYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIR 948
                                 F+ + +R E  + +  RK SVVNVNPTN RP SDTPEIR
Sbjct: 800  ---------------------FSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIR 838

Query: 949  KYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVL 1008
            KYKKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLEGLNVL
Sbjct: 839  KYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVL 898

Query: 1009 VTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVI 1068
            VTISGKK+KLRVYYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERIKFLVI
Sbjct: 899  VTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVI 958

Query: 1069 ALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDV 1128
            ALK++VE+YAWAPKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS  GFH +DV
Sbjct: 959  ALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDV 1018

Query: 1129 DSGNSYDIYIPSHIQGN--------ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRIT 1180
            DSG+ YDIY+P+H++ N        I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRIT
Sbjct: 1019 DSGSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRIT 1078

Query: 1181 KDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERND 1240
            KDVVLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERND
Sbjct: 1079 KDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERND 1138

Query: 1241 KVFFASVRSGGSSQVFFMTLNRNSMMNW 1268
            KVFFASVRSGGSSQV+FMTL R S+++W
Sbjct: 1139 KVFFASVRSGGSSQVYFMTLGRTSLLSW 1166


>gi|118600963 Nik related kinase [Homo sapiens]
          Length = 1582

 Score =  400 bits (1028), Expect = e-111
 Identities = 250/704 (35%), Positives = 366/704 (51%), Gaps = 102/704 (14%)

Query: 1   MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT- 59
           MA     R  +  DL  L DP GIF L + +G GTYG++Y G H KTG   A+KVM+   
Sbjct: 1   MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK 60

Query: 60  -----------------------GDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPG 96
                                   DEEE+++ E+N+L+KYS H+NI ++YGAF K +PPG
Sbjct: 61  TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG 120

Query: 97  MDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKG 156
              QLW+VME C AGSVTD+++ T   +LKE+WIAYICREIL+GL+HLH H+VIHRDIKG
Sbjct: 121 QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG 180

Query: 157 QNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDL 216
           QNVLLT NAEVKLVDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P  +YD++SD+
Sbjct: 181 QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV 240

Query: 217 WSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQ 276
           WS+GITAIEMAEGAPPLC++ P+ ALF+I R  AP +KS  WS+KF +F+E C +KN   
Sbjct: 241 WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF 300

Query: 277 RPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDET---EYEYSGSEEEEEEN 333
           RP +  +++HPF+RD  NER V   L  H+    KKR +K      E E +  E+     
Sbjct: 301 RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR 360

Query: 334 DSGEPS---SILNLPGESTLR---------------------------------RDFLRL 357
             G PS    +L LP  S  R                                 R F+ L
Sbjct: 361 FRG-PSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAARVFMPL 419

Query: 358 QLAN------KERSEALRRQQ--------LEQQQRENEEHKRQLLAERQKRIEEQKEQRR 403
           Q  +      K +++A +R Q        L+ Q +       Q+  +   R+        
Sbjct: 420 QALDSAPKPLKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAARVLM 479

Query: 404 RLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQ 463
            L+ Q R  + L+ Q +  +++  + Q    ++  +   E + + +  E+QRQ +  ++Q
Sbjct: 480 PLQAQVRAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQGQAPEQQ 539

Query: 464 LKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAK----------------- 506
            +  +     L+  +  ++P  ++      +  + +E+P   +                 
Sbjct: 540 QRHNQVPEQELEQNQAPEQPEVQEQAAEPAQAETEAEEPESLRVNAQVFLPLLSQDHHVL 599

Query: 507 -----EIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSE 561
                +   L+ V+ Q      +Q+   +P + +   Q  +   S R  +   NS+ +  
Sbjct: 600 LPLHLDTQVLIPVEGQTEGSPQAQAWTLEPPQAIGSVQALIEGLS-RDLLRAPNSNNSKP 658

Query: 562 NPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 605
             PL T +E    + +  Q E    K   + +++  ALA++ SP
Sbjct: 659 LGPLQTLMENLSSNRFYSQPEQAREK-KSKVSTLRQALAKRLSP 701



 Score =  274 bits (701), Expect = 3e-73
 Identities = 152/416 (36%), Positives = 233/416 (56%), Gaps = 58/416 (13%)

Query: 905  SAAALFTSELLRQEQAKLNEA--RKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAA 962
            SA A F S +L     ++ E   ++ S VNVNP  + P    P I  Y+K F SEI C +
Sbjct: 1157 SADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPLIHMYEKEFTSEICCGS 1216

Query: 963  LWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYY 1022
            LWGVNLL+GT + L L+DRSG+  +  LI RR F+Q+ VLE LN+L+TISG KN+LRVY+
Sbjct: 1217 LWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVYH 1276

Query: 1023 LSWLRNRILHNDPEVEKKQGWI--------TVGDLEGCIHYKVVKYERIKFLVIALKNAV 1074
            L+WLRN+IL+NDPE +++Q  +         +  L GC H+ V+++E   ++ IALK+++
Sbjct: 1277 LTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAIALKSSI 1336

Query: 1075 EIYAWAPK---------------------------------------PYHKF-------- 1087
             +YAWAPK                                       P ++F        
Sbjct: 1337 HLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKRPDELLH 1396

Query: 1088 -MAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNI 1146
             +  K F  L HKP+ VDL +   +RLK+ F S  G+H+ID +S    D+ +P +    I
Sbjct: 1397 LLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPKNPLEII 1456

Query: 1147 TPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWG 1206
             P  I+ILP   G+ M++ +  E + V    ++ K ++  W ++P+S+A+  + +  GWG
Sbjct: 1457 IPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRTTGWG 1516

Query: 1207 EKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNR 1262
            +KAIE+RS+++  L+     +  ++L+FLC R DK+FF S      S+V+FMTL +
Sbjct: 1517 QKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGK 1572



 Score = 37.0 bits (84), Expect = 0.12
 Identities = 36/168 (21%), Positives = 71/168 (42%), Gaps = 16/168 (9%)

Query: 350 LRRDFLRLQLANKERS--------EALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQ 401
           L RD LR   +N  +         E L   +   Q  +  E K ++   RQ   +    +
Sbjct: 643 LSRDLLRAPNSNNSKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLSPK 702

Query: 402 RRRLEEQQRREK----ELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQA 457
           R R +   R EK    +L  +++R QRR  +   + EEE R+ + ++E +    +E   +
Sbjct: 703 RFRAKSSWRPEKLELSDLEARRQRRQRRWEDIFNQHEEELRQVDKDKEDESSDNDEVFHS 762

Query: 458 ERLQRQLKQERDYLVSLQ----HQRQEQRPVEKKPLYHYKEGMSPSEK 501
            + + Q++  + Y+ + +     +R    P  +   +H K   S  ++
Sbjct: 763 IQAEVQIEPLKPYISNPKKIEVQERSPSVPNNQDHAHHVKFSSSVPQR 810


>gi|145275208 myosin IIIA [Homo sapiens]
          Length = 1616

 Score =  306 bits (785), Expect = 6e-83
 Identities = 155/311 (49%), Positives = 207/311 (66%), Gaps = 11/311 (3%)

Query: 20  DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHH 79
           DP+  +E+ E +G GTYG+V+K  + K GQ AA+K++D   D +EEI+ E N+LK  S H
Sbjct: 16  DPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEAEYNILKALSDH 75

Query: 80  RNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKN--TKGNTLKEEWIAYICREI 137
            N+  +YG + KK+     D+LWLV+E C  GSVTDL+K    +G  + E  IAYI  E 
Sbjct: 76  PNVVRFYGIYFKKDKVN-GDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEA 134

Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
           L GL HLH +K IHRD+KG N+LLT    VKLVDFGVSAQL  T  RRNT +GTP+WMAP
Sbjct: 135 LMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAP 194

Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
           EVIAC++  D TYD + D WSLGITAIE+ +G PPL D+HPMRALF IPRNP P+L+  +
Sbjct: 195 EVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPE 254

Query: 258 -WSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-----RDQPNERQVR--IQLKDHIDRT 309
            WS +F  FI  CL K++ +RP   +L++H FI     +D   ++Q+   I +   +  T
Sbjct: 255 LWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGKDVMLQKQLTEFIGIHQCMGGT 314

Query: 310 KKKRGEKDETE 320
           +K R E+  T+
Sbjct: 315 EKARRERIHTK 325



 Score = 33.1 bits (74), Expect = 1.7
 Identities = 44/211 (20%), Positives = 83/211 (39%), Gaps = 28/211 (13%)

Query: 281  EQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSS 340
            E+ +K  F    P     +  +KD  + +  ++ EK+E   +       EE N     ++
Sbjct: 1197 EEEVKQEFYLVGPEVSPKQKSVKDLEENSNLRKVEKEEAMIQSYYQRYTEERNCEESKAA 1256

Query: 341  ILNLPGESTLRRDFLRLQLANKERS------EALRRQQLEQQQRENEEHKRQLLAERQKR 394
             L     S  R  +    LA  E S        L ++ + Q     E+ K+  +  ++  
Sbjct: 1257 YLERKAISE-RPSYPVPWLAENETSFKKTLEPTLSQRSIYQNANSMEKEKKTSVVTQRAP 1315

Query: 395  IEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQ 454
            I  Q+E R RL                   RH   + R+ E   +A+ E++     ++ +
Sbjct: 1316 ICSQEEGRGRL-------------------RHETVKERQVEPVTQAQEEEDKAAVFIQSK 1356

Query: 455  RQAERLQRQLKQERDYLVSLQHQRQEQRPVE 485
             +  + ++QL+  +D + S +HQR    P E
Sbjct: 1357 YRGYKRRQQLR--KDKMSSFKHQRIVTTPTE 1385


>gi|134288915 myosin IIIB isoform 1 [Homo sapiens]
          Length = 1314

 Score =  296 bits (758), Expect = 8e-80
 Identities = 152/328 (46%), Positives = 211/328 (64%), Gaps = 11/328 (3%)

Query: 13  IDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINM 72
           + L +L DP   +E++E +G GTYG+VYK  + + G LAA+K++D   D +EEI+ E N+
Sbjct: 15  LGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNI 74

Query: 73  LKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTK--GNTLKEEWI 130
           L+   +H N+  +YG F K +   +  QLWLV+E C  GSVT+L+K     G  L E  I
Sbjct: 75  LQFLPNHPNVVKFYGMFYKADHC-VGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMI 133

Query: 131 AYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIG 190
           +YI    L GL HLH +++IHRD+KG N+LLT    VKLVDFGVSAQL  T  RRNT +G
Sbjct: 134 SYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVG 193

Query: 191 TPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPA 250
           TP+WMAPEVIAC++  D++YD + D+WSLGITAIE+ +G PPL DMHP++ LF IPRNP 
Sbjct: 194 TPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPP 253

Query: 251 PR-LKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPN-----ERQVRIQLKD 304
           P  L  +KW ++F  FI  CL+K+  +RP+   L+ HPFI+         ++Q+   L+D
Sbjct: 254 PTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQD 313

Query: 305 --HIDRTKKKRGEKDETEYEYSGSEEEE 330
             H +   K R E+  T   Y   + E+
Sbjct: 314 QKHQNPVAKTRHERMHTRRPYHVEDAEK 341


>gi|134288892 myosin IIIB isoform 2 [Homo sapiens]
          Length = 1341

 Score =  296 bits (758), Expect = 8e-80
 Identities = 152/328 (46%), Positives = 211/328 (64%), Gaps = 11/328 (3%)

Query: 13  IDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINM 72
           + L +L DP   +E++E +G GTYG+VYK  + + G LAA+K++D   D +EEI+ E N+
Sbjct: 15  LGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNI 74

Query: 73  LKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTK--GNTLKEEWI 130
           L+   +H N+  +YG F K +   +  QLWLV+E C  GSVT+L+K     G  L E  I
Sbjct: 75  LQFLPNHPNVVKFYGMFYKADHC-VGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMI 133

Query: 131 AYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIG 190
           +YI    L GL HLH +++IHRD+KG N+LLT    VKLVDFGVSAQL  T  RRNT +G
Sbjct: 134 SYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVG 193

Query: 191 TPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPA 250
           TP+WMAPEVIAC++  D++YD + D+WSLGITAIE+ +G PPL DMHP++ LF IPRNP 
Sbjct: 194 TPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPP 253

Query: 251 PR-LKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPN-----ERQVRIQLKD 304
           P  L  +KW ++F  FI  CL+K+  +RP+   L+ HPFI+         ++Q+   L+D
Sbjct: 254 PTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQD 313

Query: 305 --HIDRTKKKRGEKDETEYEYSGSEEEE 330
             H +   K R E+  T   Y   + E+
Sbjct: 314 QKHQNPVAKTRHERMHTRRPYHVEDAEK 341


>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
          Length = 487

 Score =  273 bits (698), Expect = 8e-73
 Identities = 164/417 (39%), Positives = 236/417 (56%), Gaps = 25/417 (5%)

Query: 6   PARSLDEIDLSAL-RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEE 64
           P R L ++D  +L + P  +F+++E +G G+YG VYK  H +TGQ+ AIK + V  D +E
Sbjct: 10  PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69

Query: 65  EIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNT 124
            IK+   M +  S H  +  YYG++ K         LW+VME+CGAGSV+D+I+  +  T
Sbjct: 70  IIKEISIMQQCDSPH--VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120

Query: 125 LKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
           L E+ IA I +  L+GL +LH  + IHRDIK  N+LL      KL DFGV+ QL  T+ +
Sbjct: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180

Query: 185 RNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFL 244
           RNT IGTP+WMAPEVI      +  Y+  +D+WSLGITAIEMAEG PP  D+HPMRA+F+
Sbjct: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235

Query: 245 IPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLK 303
           IP NP P   K + WS  F  F++ CLVK+  QR    QL++HPF+R       +R  + 
Sbjct: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLIN 295

Query: 304 DHIDRTKKKRGEKDETEYEYSGSE-EEEEENDSGEPSSILNLPGE--STLRRDFLRLQLA 360
           + +D  K KR E  + E +    E  EE+E DSG   +++   G+   T+R        A
Sbjct: 296 EAMD-VKLKRQESQQREVDQDDEENSEEDEMDSG---TMVRAVGDEMGTVRVASTMTDGA 351

Query: 361 NK--ERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKEL 415
           N   E  + L  Q         +E +   +  R + ++  K       EQ+ +E ++
Sbjct: 352 NTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQI 408


>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
           [Homo sapiens]
          Length = 894

 Score =  266 bits (679), Expect = 1e-70
 Identities = 141/297 (47%), Positives = 197/297 (66%), Gaps = 15/297 (5%)

Query: 14  DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINML 73
           DLS  R+P   FEL++ +G+GTYG VYK R+V TG+LAAIKV+ +   E+  + Q+  ++
Sbjct: 6   DLSR-RNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIM 64

Query: 74  KKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYI 133
            K   H NI  Y+G+++++      D+LW+ MEFCG GS+ D+   T    L E  IAY+
Sbjct: 65  MKDCKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYV 116

Query: 134 CREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
            RE L+GL +LH    +HRDIKG N+LLT+N  VKL DFGVSAQ+  T+ +R +FIGTPY
Sbjct: 117 SRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPY 176

Query: 194 WMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAP 251
           WMAPEV A +      Y+   DLW++GITAIE+AE  PP+ D+HPMRALFL+ ++    P
Sbjct: 177 WMAPEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPP 234

Query: 252 RLKSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHID 307
           +LK K KWS  F  F++  L KN  +RP  E+L++HPF+  Q   R + I+L D ++
Sbjct: 235 KLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV-TQHLTRSLAIELLDKVN 290


>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
           [Homo sapiens]
          Length = 846

 Score =  263 bits (672), Expect = 8e-70
 Identities = 149/369 (40%), Positives = 224/369 (60%), Gaps = 38/369 (10%)

Query: 19  RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKYS 77
           R+P   +ELV+ VG+GTYG VYK R+V TG+LAA+K++ +  GD+   I+QEI M+K+  
Sbjct: 14  RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73

Query: 78  HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
           H  NI  Y+G+++ +      ++LW+ ME+CG GS+ D+   T    L E  IAY+CRE 
Sbjct: 74  HC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRET 124

Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
           L+GL++LH    +HRDIKG N+LLT++ +VKL DFGV+A++  T+ +R +FIGTPYWMAP
Sbjct: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184

Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 255
           EV A ++N    Y+   D+W++GITAIE+ E  PP+ D+HPMRALFL+ ++    P+LK 
Sbjct: 185 EVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242

Query: 256 K-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314
           K KWS  F +F++  L KN  +RP  E+L+ H F+      R + ++L D ++       
Sbjct: 243 KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN------- 295

Query: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRR----------DFLRLQLANKER 364
              +    Y+     E ++D  EP +I+     ST R           +F +LQ     R
Sbjct: 296 -NPDNHAHYT-----EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLR 349

Query: 365 SEALRRQQL 373
            E   R ++
Sbjct: 350 KETEARDEM 358


>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
           [Homo sapiens]
          Length = 846

 Score =  263 bits (672), Expect = 8e-70
 Identities = 149/369 (40%), Positives = 224/369 (60%), Gaps = 38/369 (10%)

Query: 19  RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKYS 77
           R+P   +ELV+ VG+GTYG VYK R+V TG+LAA+K++ +  GD+   I+QEI M+K+  
Sbjct: 14  RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73

Query: 78  HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
           H  NI  Y+G+++ +      ++LW+ ME+CG GS+ D+   T    L E  IAY+CRE 
Sbjct: 74  HC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRET 124

Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
           L+GL++LH    +HRDIKG N+LLT++ +VKL DFGV+A++  T+ +R +FIGTPYWMAP
Sbjct: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184

Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 255
           EV A ++N    Y+   D+W++GITAIE+ E  PP+ D+HPMRALFL+ ++    P+LK 
Sbjct: 185 EVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242

Query: 256 K-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314
           K KWS  F +F++  L KN  +RP  E+L+ H F+      R + ++L D ++       
Sbjct: 243 KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN------- 295

Query: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRR----------DFLRLQLANKER 364
              +    Y+     E ++D  EP +I+     ST R           +F +LQ     R
Sbjct: 296 -NPDNHAHYT-----EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLR 349

Query: 365 SEALRRQQL 373
            E   R ++
Sbjct: 350 KETEARDEM 358


>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
          Length = 491

 Score =  260 bits (665), Expect = 5e-69
 Identities = 149/338 (44%), Positives = 208/338 (61%), Gaps = 24/338 (7%)

Query: 2   ASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGD 61
           A  S  + L E  L+  + P  +F+++E +G G+YG V+K  H ++GQ+ AIK + V  D
Sbjct: 6   APKSKLKKLSEDSLT--KQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD 63

Query: 62  EEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTK 121
            +E IK EI+++++      +  YYG++ K         LW+VME+CGAGSV+D+I+  +
Sbjct: 64  LQEIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LR 114

Query: 122 GNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
             TL E+ IA I +  L+GL +LH  + IHRDIK  N+LL      KL DFGV+ QL  T
Sbjct: 115 NKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDT 174

Query: 182 VGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA 241
           + +RNT IGTP+WMAPEVI      +  Y+  +D+WSLGIT+IEMAEG PP  D+HPMRA
Sbjct: 175 MAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRA 229

Query: 242 LFLIPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
           +F+IP NP P   K + WS  F  F++ CLVKN  QR    QL++HPFI+   N + V I
Sbjct: 230 IFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK---NAKPVSI 286

Query: 301 QLKDHIDRT---KKKRGEKDETEYEYSGSEEEEEENDS 335
            L+D I      K KR E+ + E E      +E+E DS
Sbjct: 287 -LRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDS 323


>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
          Length = 426

 Score =  259 bits (663), Expect = 9e-69
 Identities = 142/319 (44%), Positives = 202/319 (63%), Gaps = 19/319 (5%)

Query: 20  DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77
           DP  +F  ++ +G G++G+VYKG    T ++ AIK++D+    DE E+I+QEI +L +  
Sbjct: 15  DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74

Query: 78  HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
               I  Y+G+++K        +LW++ME+ G GS  DL+K      L+E +IA I REI
Sbjct: 75  SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124

Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
           L+GL +LH  + IHRDIK  NVLL+E  +VKL DFGV+ QL  T  +RNTF+GTP+WMAP
Sbjct: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184

Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
           EVI       + YDFK+D+WSLGITAIE+A+G PP  D+HPMR LFLIP+N  P L+ + 
Sbjct: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239

Query: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
            SK F+ F+E+CL K+   RP  ++L+KH FI     +     +L D   R K + G  +
Sbjct: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSE-GHGE 297

Query: 318 ETEYEYSGSEEEEEENDSG 336
           E+  E S  + E E+ + G
Sbjct: 298 ESSSEDSDIDGEAEDGEQG 316


>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
           sapiens]
          Length = 416

 Score =  259 bits (661), Expect = 1e-68
 Identities = 141/320 (44%), Positives = 201/320 (62%), Gaps = 18/320 (5%)

Query: 18  LRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKK 75
           + DP  +F  +E +G G++G+V+KG   +T Q+ AIK++D+    DE E+I+QEI +L +
Sbjct: 17  IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76

Query: 76  YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
                 +  YYG+++K +      +LW++ME+ G GS  DL++        E  IA + +
Sbjct: 77  CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126

Query: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
           EIL+GL +LH  K IHRDIK  NVLL+E  +VKL DFGV+ QL  T  +RNTF+GTP+WM
Sbjct: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186

Query: 196 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS 255
           APEVI       + YD K+D+WSLGITAIE+A+G PP  DMHPMR LFLIP+N  P L  
Sbjct: 187 APEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG 241

Query: 256 KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315
             ++K F+ FI++CL K+ S RP  ++L+KH FI     +     +L D   R K +   
Sbjct: 242 -DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300

Query: 316 KDETEYEYSGSEEEEEENDS 335
            DE++ E S SE    EN++
Sbjct: 301 DDESDSEGSDSESTSRENNT 320


>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
          Length = 1235

 Score =  255 bits (652), Expect = 2e-67
 Identities = 218/827 (26%), Positives = 366/827 (44%), Gaps = 90/827 (10%)

Query: 20  DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE-EEIKQEINMLKKYSH 78
           +P   +E++  +G+G +G+VYK ++ +T  LAA KV+D   +EE E+   EI++L    H
Sbjct: 29  NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88

Query: 79  HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
             NI     AF  +N       LW+++EFC  G+V D +       L E  I  +C++ L
Sbjct: 89  P-NIVKLLDAFYYEN------NLWILIEFCAGGAV-DAVMLELERPLTESQIQVVCKQTL 140

Query: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
             L++LH +K+IHRD+K  N+L T + ++KL DFGVSA+  RT+ RR++FIGTPYWMAPE
Sbjct: 141 DALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPE 200

Query: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRL-KSKK 257
           V+ C+ + D  YD+K+D+WSLGIT IEMAE  PP  +++PMR L  I ++  P L +  +
Sbjct: 201 VVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSR 260

Query: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
           WS  F+ F++ CL KN   R  T QL++HPF+    N+      +++ I   K      +
Sbjct: 261 WSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNK-----PIRELIAEAK-----AE 310

Query: 318 ETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKE-----RSEALRRQQ 372
            TE    G EE+EEE    E  + L +P       D   L +A+ E     ++  +    
Sbjct: 311 VTEEVEDGKEEDEEE----ETENSLPIPASKRASSD---LSIASSEEDKLSQNACILESV 363

Query: 373 LEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMR 432
            E+ +R N E K       +K   ++ E+      +   + +L    E   R    ++  
Sbjct: 364 SEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENE 423

Query: 433 REEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHY 492
           RE+  +         ++ ++    +E  +  +    +  +    + +E++  EK+ ++  
Sbjct: 424 REKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFEN 483

Query: 493 KEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMP 552
           K   S   K    + +   +  +  G      Q+V  +        QE L       E  
Sbjct: 484 KLIKSEEIKDTILQTVD--LVSQETGEKEANIQAVDSEVGLTKEDTQEKLG------EDD 535

Query: 553 RQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALG 612
           +   D  S    +    E  D              V Q+    S    + N       +G
Sbjct: 536 KTQKDVISNTSDVIGTCEAAD--------------VAQKVDEDSAEDTQSNDGKEVVEVG 581

Query: 613 PRLGSQPIRASNPDLRRTEPILE-SPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSS 671
            +L ++P+        +  PI E   +     G +   +  SS+       +PG+  G  
Sbjct: 582 QKLINKPMVGPEAGGTKEVPIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEG-E 640

Query: 672 ERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELRELRIEETNRPM 731
           E T   +  + E   V+     K    E +D ++ +     T + KE +E+ +     P 
Sbjct: 641 EITESSSTEEMEVRSVVADTDQKALGSEVQDASKVT-----TQIDKEKKEIPVSIKKEP- 694

Query: 732 KKVTDYSSSSE-----------ESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSN 780
            +VT  S  +E            S+S E +EE G         ++S    ++P  +    
Sbjct: 695 -EVTVVSQPTEPQPVLIPSININSDSGENKEEIG---------SLSKTETILPPESENPK 744

Query: 781 EQYNVGMVGTHGLETSHAD------SFSGSISREGTLMIRETSGEKK 821
           E  N    G+   +TS  D      SF       G++ ++ET  +KK
Sbjct: 745 ENDNDSGTGSTA-DTSSIDLNLSISSFLSKTKDSGSISLQETRRQKK 790



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 44/192 (22%), Positives = 88/192 (45%), Gaps = 31/192 (16%)

Query: 350  LRRDFLRLQLANKERSEALRRQQLEQQ-QRENEEHKRQLLAERQKRIEEQKEQRRRLEEQ 408
            LRR  LR +L   ++ E   +QQL  + Q++ E+  R+   E   +  +  ++   LE+Q
Sbjct: 826  LRRQELR-ELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQ 884

Query: 409  QRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYK-----------------RKQL 451
            Q++  E  +Q+   + R   ++++ E+E+  ++ +   K                 RK+L
Sbjct: 885  QKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKEL 944

Query: 452  EEQRQAERLQRQLKQERDYLVS------------LQHQRQEQRPVEKKPLYHYKEGMSPS 499
             ++R+ E  Q Q  QE++++              +Q Q+ E   +E++ L + ++ M   
Sbjct: 945  MKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAR 1004

Query: 500  EKPAWAKEIPHL 511
            E   W  E  HL
Sbjct: 1005 EAAIWELEERHL 1016



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 54/232 (23%), Positives = 102/232 (43%), Gaps = 20/232 (8%)

Query: 262  FQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEY 321
            F+ F +  + K        E L K      +  E++   +L+D   R K ++ EK+ +++
Sbjct: 860  FRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQ-EKELSKF 918

Query: 322  EYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQ--------- 372
            +      ++E  +  E +    L  E   RR     Q  + +  E +++QQ         
Sbjct: 919  QNMLKNRKKEVINEVEKAP-KELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKK 977

Query: 373  -LEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK-ELRKQQEREQRRHYEEQ 430
             ++QQ+ E    +R+ L  +Q+ +  ++     LEE+  +EK +L KQQ ++Q      Q
Sbjct: 978  IIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQ 1037

Query: 431  MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQR 482
            + +        HE+E ++ Q   QR  E L+ +  QER  L  +Q    + R
Sbjct: 1038 LLK-------RHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTR 1082



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 37/145 (25%), Positives = 73/145 (50%), Gaps = 16/145 (11%)

Query: 363 ERSEALRRQQLEQ---QQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQ 419
           E    LRRQ+L +    Q+E +  ++QL      ++++Q+EQ  R  EQ+   K+ +  Q
Sbjct: 821 EELRFLRRQELRELRFLQKEEQRAQQQL----NSKLQQQREQIFRRFEQEMMSKKRQYDQ 876

Query: 420 EREQRRHYEEQMRREEERRRAEH----EQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
           E E   + E+Q ++  ER   EH      E KR + E++++  + Q  LK  +  +++  
Sbjct: 877 EIE---NLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVIN-- 931

Query: 476 HQRQEQRPVEKKPLYHYKEGMSPSE 500
              +  + + K+ +   KE ++ S+
Sbjct: 932 EVEKAPKELRKELMKRRKEELAQSQ 956



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 43/177 (24%), Positives = 90/177 (50%), Gaps = 34/177 (19%)

Query: 351  RRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEE----QKEQRRRLE 406
            +   L+ QL  K++    R Q L++ ++E E+ +R      Q+ IEE    Q ++R RL 
Sbjct: 1019 KHQLLKQQL--KDQYFMQRHQLLKRHEKETEQMQRY----NQRLIEELKNRQTQERARLP 1072

Query: 407  EQQRREKELRK---------------QQEREQRRHY--EEQMRREEER--RRAEHEQEYK 447
            + QR E + R                 Q+R++ + +  +E+ R++ ER  +  +HE + +
Sbjct: 1073 KIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMR 1132

Query: 448  RKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEK---KPLYHYKEGMSPSEK 501
              QL+ +     L  QL+ E+ +L+ ++H+ Q+ + +++   + L  ++E + P +K
Sbjct: 1133 DLQLQCEANVREL-HQLQNEKCHLL-VEHETQKLKELDEEHSQELKEWREKLRPRKK 1187



 Score = 35.4 bits (80), Expect = 0.35
 Identities = 42/191 (21%), Positives = 82/191 (42%), Gaps = 26/191 (13%)

Query: 292  QPNERQVRIQLKDH--IDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGEST 349
            Q   + ++ QLKD   + R +  +  + ETE     ++   EE  + +      LP    
Sbjct: 1017 QEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLP---K 1073

Query: 350  LRRDFLRLQLANKERSEALRRQQLEQQQREN------EEHKRQL---LAERQKRIEEQKE 400
            ++R   + ++A  ++S  +       Q R+       +E KRQ    +A+ QK   + ++
Sbjct: 1074 IQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRD 1133

Query: 401  QRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYK--------RKQLE 452
             + + E   R   +L+ ++      H  ++++  +E    EH QE K        RK+  
Sbjct: 1134 LQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDE----EHSQELKEWREKLRPRKKTL 1189

Query: 453  EQRQAERLQRQ 463
            E+  A +LQ Q
Sbjct: 1190 EEEFARKLQEQ 1200



 Score = 34.3 bits (77), Expect = 0.78
 Identities = 55/300 (18%), Positives = 121/300 (40%), Gaps = 49/300 (16%)

Query: 254  KSKKWSKKFQSFI---------ESCLVKNHSQRPATEQLMKHPFIRD----QPNERQVRI 300
            + KK  KK + FI          S +V +   +    + ++   +R+    Q  E++ + 
Sbjct: 787  RQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQ 846

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
            QL   + + +++   + E E      + ++E         I NL  +     + L  +  
Sbjct: 847  QLNSKLQQQREQIFRRFEQEMMSKKRQYDQE---------IENLEKQQKQTIERLEQEHT 897

Query: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQ---QRREKELRK 417
            N+ R EA R +   +Q++E  + +  L   +++ I E ++  + L ++   +R+E+  + 
Sbjct: 898  NRLRDEAKRIKG--EQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQS 955

Query: 418  QQEREQRRHYEEQMRREE----------------ERRRAEHEQEYKRK------QLEEQR 455
            Q  +EQ    ++Q   +                 ER    ++Q+  R       +LEE+ 
Sbjct: 956  QHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERH 1015

Query: 456  QAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVK 515
              E+ Q   +Q +D     +HQ  ++   E + +  Y + +    K    +E   L  ++
Sbjct: 1016 LQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQ 1075



 Score = 30.8 bits (68), Expect = 8.6
 Identities = 44/207 (21%), Positives = 78/207 (37%), Gaps = 22/207 (10%)

Query: 862  SQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAK 921
            ++E++ G E      T+ S       R          EED+ S  A +  S   + E++ 
Sbjct: 312  TEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSN 371

Query: 922  LNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDR 981
              +     ++N  PT     +D PE  K  +  N  I  A L  +  L      +   +R
Sbjct: 372  SEDKLNSKILNEKPT-----TDEPE--KAVEDINEHITDAQLEAMTELHDRTAVIKENER 424

Query: 982  SGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQ 1041
              + K+ NL +    + +D+           GK+N + +     L   I HN    E+K 
Sbjct: 425  EKRPKLENLPDTEDQETVDINS------VSEGKENNIMI----TLETNIEHNLKSEEEKD 474

Query: 1042 GWITVGDLEGCIHYKVVKYERIKFLVI 1068
                  + +     K++K E IK  ++
Sbjct: 475  -----QEKQQMFENKLIKSEEIKDTIL 496


>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
          Length = 431

 Score =  253 bits (647), Expect = 6e-67
 Identities = 141/317 (44%), Positives = 201/317 (63%), Gaps = 24/317 (7%)

Query: 20  DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77
           DP  +F  +E +G G++G+V+KG   +T ++ AIK++D+    DE E+I+QEI +L +  
Sbjct: 19  DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78

Query: 78  HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
               +  YYG+++K      D +LW++ME+ G GS  DL++      L E  IA I REI
Sbjct: 79  SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128

Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
           L+GL +LH  K IHRDIK  NVLL+E+ EVKL DFGV+ QL  T  +RNTF+GTP+WMAP
Sbjct: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188

Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
           EVI       + YD K+D+WSLGITAIE+A G PP  ++HPM+ LFLIP+N  P L+   
Sbjct: 189 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 242

Query: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
           +SK  + F+E+CL K  S RP  ++L+KH FI     +     +L   IDR K+ + E+ 
Sbjct: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQ- 298

Query: 318 ETEYEYSGSEEEEEEND 334
              ++ S SE+ + E D
Sbjct: 299 --SHDDSSSEDSDAETD 313


>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
          Length = 443

 Score =  253 bits (647), Expect = 6e-67
 Identities = 141/317 (44%), Positives = 201/317 (63%), Gaps = 24/317 (7%)

Query: 20  DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77
           DP  +F  +E +G G++G+V+KG   +T ++ AIK++D+    DE E+I+QEI +L +  
Sbjct: 31  DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 90

Query: 78  HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
               +  YYG+++K      D +LW++ME+ G GS  DL++      L E  IA I REI
Sbjct: 91  SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 140

Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
           L+GL +LH  K IHRDIK  NVLL+E+ EVKL DFGV+ QL  T  +RNTF+GTP+WMAP
Sbjct: 141 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 200

Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
           EVI       + YD K+D+WSLGITAIE+A G PP  ++HPM+ LFLIP+N  P L+   
Sbjct: 201 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 254

Query: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
           +SK  + F+E+CL K  S RP  ++L+KH FI     +     +L   IDR K+ + E+ 
Sbjct: 255 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQ- 310

Query: 318 ETEYEYSGSEEEEEEND 334
              ++ S SE+ + E D
Sbjct: 311 --SHDDSSSEDSDAETD 325


>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
           [Homo sapiens]
          Length = 820

 Score =  249 bits (637), Expect = 9e-66
 Identities = 129/280 (46%), Positives = 184/280 (65%), Gaps = 15/280 (5%)

Query: 17  ALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKK 75
           +L+DP   FEL++ VG GTYG VYK R   T +LAA+K++ +  GD+   ++QEI +L++
Sbjct: 8   SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67

Query: 76  YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
              H N+  Y G++++      +D+LW+ MEFCG GS+ ++   T    L+E  IAY+CR
Sbjct: 68  -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118

Query: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
           E L+GL HLH    IHRDIKG N+LLT   +VKL DFGVS +L  +V +R +FIGTPYWM
Sbjct: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178

Query: 196 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRL 253
           APEV A +      Y+   D+W+LGITAIE+ E  PPL  +HPMRAL L+ ++    P+L
Sbjct: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236

Query: 254 KSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQ 292
           + K +W++ F  F++  L KN  +RP  E+L++HPF   Q
Sbjct: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ 276


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.130    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,027,393
Number of Sequences: 37866
Number of extensions: 2695751
Number of successful extensions: 69074
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1601
Number of HSP's successfully gapped in prelim test: 1677
Number of HSP's that attempted gapping in prelim test: 18073
Number of HSP's gapped (non-prelim): 19838
length of query: 1268
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1154
effective length of database: 13,930,794
effective search space: 16076136276
effective search space used: 16076136276
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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