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Search of human proteins with 239735592
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
(1268 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 2543 0.0
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 2536 0.0
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 2528 0.0
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 2521 0.0
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 2498 0.0
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 2490 0.0
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 2482 0.0
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 2475 0.0
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 1608 0.0
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 1587 0.0
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 1584 0.0
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 1578 0.0
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 1577 0.0
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 1572 0.0
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 1536 0.0
gi|118600963 Nik related kinase [Homo sapiens] 400 e-111
gi|145275208 myosin IIIA [Homo sapiens] 306 6e-83
gi|134288915 myosin IIIB isoform 1 [Homo sapiens] 296 8e-80
gi|134288892 myosin IIIB isoform 2 [Homo sapiens] 296 8e-80
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 273 8e-73
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 266 1e-70
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 263 8e-70
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 263 8e-70
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 260 5e-69
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 259 9e-69
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 259 1e-68
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 255 2e-67
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 253 6e-67
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 253 6e-67
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 249 9e-66
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 2543 bits (6592), Expect = 0.0
Identities = 1268/1268 (100%), Positives = 1268/1268 (100%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
Query: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
Query: 421 REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480
REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE
Sbjct: 421 REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480
Query: 481 QRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQE 540
QRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQE
Sbjct: 481 QRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQE 540
Query: 541 ALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALA 600
ALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALA
Sbjct: 541 ALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALA 600
Query: 601 RKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQG 660
RKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQG
Sbjct: 601 RKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQG 660
Query: 661 GSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELR 720
GSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELR
Sbjct: 661 GSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELR 720
Query: 721 ELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSN 780
ELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSN
Sbjct: 721 ELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSN 780
Query: 781 EQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDL 840
EQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDL
Sbjct: 781 EQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDL 840
Query: 841 VQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEE 900
VQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEE
Sbjct: 841 VQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEE 900
Query: 901 DEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILC 960
DEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILC
Sbjct: 901 DEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILC 960
Query: 961 AALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRV 1020
AALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRV
Sbjct: 961 AALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRV 1020
Query: 1021 YYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWA 1080
YYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWA
Sbjct: 1021 YYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWA 1080
Query: 1081 PKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPS 1140
PKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPS
Sbjct: 1081 PKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPS 1140
Query: 1141 HIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSN 1200
HIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSN
Sbjct: 1141 HIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSN 1200
Query: 1201 QIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTL 1260
QIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTL
Sbjct: 1201 QIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTL 1260
Query: 1261 NRNSMMNW 1268
NRNSMMNW
Sbjct: 1261 NRNSMMNW 1268
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 2536 bits (6573), Expect = 0.0
Identities = 1268/1276 (99%), Positives = 1268/1276 (99%), Gaps = 8/1276 (0%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
Query: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
Query: 421 REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480
REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE
Sbjct: 421 REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480
Query: 481 QRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQE 540
QRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQE
Sbjct: 481 QRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQE 540
Query: 541 ALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALA 600
ALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALA
Sbjct: 541 ALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALA 600
Query: 601 RKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQG 660
RKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQG
Sbjct: 601 RKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQG 660
Query: 661 GSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA--------DL 712
GSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA DL
Sbjct: 661 GSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDL 720
Query: 713 TALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLI 772
TALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLI
Sbjct: 721 TALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLI 780
Query: 773 PTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFA 832
PTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFA
Sbjct: 781 PTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFA 840
Query: 833 GHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQT 892
GHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQT
Sbjct: 841 GHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQT 900
Query: 893 SPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKK 952
SPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKK
Sbjct: 901 SPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKK 960
Query: 953 RFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTIS 1012
RFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTIS
Sbjct: 961 RFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTIS 1020
Query: 1013 GKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKN 1072
GKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKN
Sbjct: 1021 GKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKN 1080
Query: 1073 AVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGN 1132
AVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGN
Sbjct: 1081 AVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGN 1140
Query: 1133 SYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPT 1192
SYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPT
Sbjct: 1141 SYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPT 1200
Query: 1193 SVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS 1252
SVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS
Sbjct: 1201 SVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS 1260
Query: 1253 SQVFFMTLNRNSMMNW 1268
SQVFFMTLNRNSMMNW
Sbjct: 1261 SQVFFMTLNRNSMMNW 1276
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 2528 bits (6552), Expect = 0.0
Identities = 1268/1297 (97%), Positives = 1268/1297 (97%), Gaps = 29/1297 (2%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
Query: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
Query: 421 REQRRHYEEQMRREEERRRAEHEQEY-----------------------------KRKQL 451
REQRRHYEEQMRREEERRRAEHEQEY KRKQL
Sbjct: 421 REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480
Query: 452 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHL 511
EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHL
Sbjct: 481 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHL 540
Query: 512 VAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEK 571
VAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEK
Sbjct: 541 VAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEK 600
Query: 572 FDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTE 631
FDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTE
Sbjct: 601 FDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTE 660
Query: 632 PILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHE 691
PILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHE
Sbjct: 661 PILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHE 720
Query: 692 PAKVKPEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEE 751
PAKVKPEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEE
Sbjct: 721 PAKVKPEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEE 780
Query: 752 EDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTL 811
EDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTL
Sbjct: 781 EDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTL 840
Query: 812 MIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEY 871
MIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEY
Sbjct: 841 MIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEY 900
Query: 872 GMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVV 931
GMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVV
Sbjct: 901 GMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVV 960
Query: 932 NVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLI 991
NVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLI
Sbjct: 961 NVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLI 1020
Query: 992 NRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEG 1051
NRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEG
Sbjct: 1021 NRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEG 1080
Query: 1052 CIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQ 1111
CIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQ
Sbjct: 1081 CIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQ 1140
Query: 1112 RLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGV 1171
RLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGV
Sbjct: 1141 RLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGV 1200
Query: 1172 YVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQR 1231
YVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQR
Sbjct: 1201 YVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQR 1260
Query: 1232 LKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1268
LKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Sbjct: 1261 LKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1297
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 2521 bits (6533), Expect = 0.0
Identities = 1268/1305 (97%), Positives = 1268/1305 (97%), Gaps = 37/1305 (2%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
Query: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
Query: 421 REQRRHYEEQMRREEERRRAEHEQEY-----------------------------KRKQL 451
REQRRHYEEQMRREEERRRAEHEQEY KRKQL
Sbjct: 421 REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480
Query: 452 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHL 511
EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHL
Sbjct: 481 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHL 540
Query: 512 VAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEK 571
VAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEK
Sbjct: 541 VAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEK 600
Query: 572 FDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTE 631
FDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTE
Sbjct: 601 FDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTE 660
Query: 632 PILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHE 691
PILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHE
Sbjct: 661 PILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHE 720
Query: 692 PAKVKPEESRDITRPSRPA--------DLTALAKELRELRIEETNRPMKKVTDYSSSSEE 743
PAKVKPEESRDITRPSRPA DLTALAKELRELRIEETNRPMKKVTDYSSSSEE
Sbjct: 721 PAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEE 780
Query: 744 SESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSG 803
SESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSG
Sbjct: 781 SESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSG 840
Query: 804 SISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQ 863
SISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQ
Sbjct: 841 SISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQ 900
Query: 864 EMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLN 923
EMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLN
Sbjct: 901 EMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLN 960
Query: 924 EARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSG 983
EARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSG
Sbjct: 961 EARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSG 1020
Query: 984 QGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGW 1043
QGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGW
Sbjct: 1021 QGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGW 1080
Query: 1044 ITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLV 1103
ITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLV
Sbjct: 1081 ITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLV 1140
Query: 1104 DLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEML 1163
DLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEML
Sbjct: 1141 DLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEML 1200
Query: 1164 VCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGV 1223
VCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGV
Sbjct: 1201 VCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGV 1260
Query: 1224 FMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1268
FMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Sbjct: 1261 FMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1305
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 2498 bits (6473), Expect = 0.0
Identities = 1260/1323 (95%), Positives = 1263/1323 (95%), Gaps = 55/1323 (4%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
Query: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
Query: 421 REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480
REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE
Sbjct: 421 REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480
Query: 481 QRPVEKKPLYHYKEGMS------------------------------------------- 497
QRPVEKKPLYHYKEGMS
Sbjct: 481 QRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSE 540
Query: 498 --------PSEKPAWAK----EIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT 545
P+ P + +IPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT
Sbjct: 541 SFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT 600
Query: 546 SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 605
SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP
Sbjct: 601 SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 660
Query: 606 GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG 665
GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG
Sbjct: 661 GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG 720
Query: 666 SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELRELRIE 725
SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELRELRIE
Sbjct: 721 SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELRELRIE 780
Query: 726 ETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNV 785
ETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNV
Sbjct: 781 ETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNV 840
Query: 786 GMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSH 845
GMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSH
Sbjct: 841 GMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSH 900
Query: 846 SPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESS 905
SPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESS
Sbjct: 901 SPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESS 960
Query: 906 AAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWG 965
AAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWG
Sbjct: 961 AAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWG 1020
Query: 966 VNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSW 1025
VNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSW
Sbjct: 1021 VNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSW 1080
Query: 1026 LRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYH 1085
LRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYH
Sbjct: 1081 LRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYH 1140
Query: 1086 KFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGN 1145
KFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGN
Sbjct: 1141 KFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGN 1200
Query: 1146 ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGW 1205
ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGW
Sbjct: 1201 ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGW 1260
Query: 1206 GEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSM 1265
GEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSM
Sbjct: 1261 GEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSM 1320
Query: 1266 MNW 1268
MNW
Sbjct: 1321 MNW 1323
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 2490 bits (6454), Expect = 0.0
Identities = 1260/1331 (94%), Positives = 1263/1331 (94%), Gaps = 63/1331 (4%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
Query: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
Query: 421 REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480
REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE
Sbjct: 421 REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480
Query: 481 QRPVEKKPLYHYKEGMS------------------------------------------- 497
QRPVEKKPLYHYKEGMS
Sbjct: 481 QRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSE 540
Query: 498 --------PSEKPAWAK----EIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT 545
P+ P + +IPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT
Sbjct: 541 SFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT 600
Query: 546 SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 605
SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP
Sbjct: 601 SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 660
Query: 606 GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG 665
GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG
Sbjct: 661 GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG 720
Query: 666 SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA--------DLTALAK 717
SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA DLTALAK
Sbjct: 721 SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAK 780
Query: 718 ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP 777
ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP
Sbjct: 781 ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP 840
Query: 778 GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINL 837
GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINL
Sbjct: 841 GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINL 900
Query: 838 PDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDE 897
PDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDE
Sbjct: 901 PDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDE 960
Query: 898 DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE 957
DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE
Sbjct: 961 DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE 1020
Query: 958 ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK 1017
ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK
Sbjct: 1021 ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK 1080
Query: 1018 LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY 1077
LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY
Sbjct: 1081 LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY 1140
Query: 1078 AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY 1137
AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY
Sbjct: 1141 AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY 1200
Query: 1138 IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI 1197
IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI
Sbjct: 1201 IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI 1260
Query: 1198 HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF 1257
HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF
Sbjct: 1261 HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF 1320
Query: 1258 MTLNRNSMMNW 1268
MTLNRNSMMNW
Sbjct: 1321 MTLNRNSMMNW 1331
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 2482 bits (6433), Expect = 0.0
Identities = 1260/1352 (93%), Positives = 1263/1352 (93%), Gaps = 84/1352 (6%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
Query: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
Query: 421 REQRRHYEEQMRREEERRRAEHEQEY-----------------------------KRKQL 451
REQRRHYEEQMRREEERRRAEHEQEY KRKQL
Sbjct: 421 REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480
Query: 452 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMS-------------- 497
EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMS
Sbjct: 481 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 540
Query: 498 -------------------------------------PSEKPAWAK----EIPHLVAVKS 516
P+ P + +IPHLVAVKS
Sbjct: 541 SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 600
Query: 517 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 576
QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS
Sbjct: 601 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 660
Query: 577 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 636
WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES
Sbjct: 661 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 720
Query: 637 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 696
PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK
Sbjct: 721 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 780
Query: 697 PEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGES 756
PEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGES
Sbjct: 781 PEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGES 840
Query: 757 ETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET 816
ETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET
Sbjct: 841 ETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET 900
Query: 817 SGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSS 876
SGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSS
Sbjct: 901 SGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSS 960
Query: 877 TKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPT 936
TKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPT
Sbjct: 961 TKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPT 1020
Query: 937 NIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRF 996
NIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRF
Sbjct: 1021 NIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRF 1080
Query: 997 QQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYK 1056
QQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYK
Sbjct: 1081 QQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYK 1140
Query: 1057 VVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVI 1116
VVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVI
Sbjct: 1141 VVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVI 1200
Query: 1117 FGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTY 1176
FGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTY
Sbjct: 1201 FGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTY 1260
Query: 1177 GRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC 1236
GRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC
Sbjct: 1261 GRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC 1320
Query: 1237 ERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1268
ERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Sbjct: 1321 ERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1352
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sapiens]
Length = 1360
Score = 2475 bits (6414), Expect = 0.0
Identities = 1260/1360 (92%), Positives = 1263/1360 (92%), Gaps = 92/1360 (6%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
Query: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
Query: 421 REQRRHYEEQMRREEERRRAEHEQEY-----------------------------KRKQL 451
REQRRHYEEQMRREEERRRAEHEQEY KRKQL
Sbjct: 421 REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480
Query: 452 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMS-------------- 497
EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMS
Sbjct: 481 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 540
Query: 498 -------------------------------------PSEKPAWAK----EIPHLVAVKS 516
P+ P + +IPHLVAVKS
Sbjct: 541 SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 600
Query: 517 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 576
QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS
Sbjct: 601 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 660
Query: 577 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 636
WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES
Sbjct: 661 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 720
Query: 637 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 696
PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK
Sbjct: 721 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 780
Query: 697 PEESRDITRPSRPA--------DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE 748
PEESRDITRPSRPA DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE
Sbjct: 781 PEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE 840
Query: 749 EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE 808
EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE
Sbjct: 841 EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE 900
Query: 809 GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 868
GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG
Sbjct: 901 GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 960
Query: 869 TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI 928
TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI
Sbjct: 961 TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI 1020
Query: 929 SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY 988
SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY
Sbjct: 1021 SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY 1080
Query: 989 NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD 1048
NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD
Sbjct: 1081 NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD 1140
Query: 1049 LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE 1108
LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE
Sbjct: 1141 LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE 1200
Query: 1109 EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED 1168
EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED
Sbjct: 1201 EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED 1260
Query: 1169 EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR 1228
EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR
Sbjct: 1261 EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR 1320
Query: 1229 AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1268
AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Sbjct: 1321 AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1360
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 1608 bits (4163), Expect = 0.0
Identities = 877/1369 (64%), Positives = 1004/1369 (73%), Gaps = 158/1369 (11%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
Query: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
Query: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
QE+EQ+R E+ +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE YL SLQ
Sbjct: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
Query: 476 HQRQEQR----------PVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQ-------- 517
Q+Q+Q+ P ++KPLYHY GM+P++KPAWA+E+ + Q
Sbjct: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Query: 518 ----------------GPALTASQ----------------SVHEQPTKGLSGFQEALN-- 543
GP SQ S+ +QPT+ L+ F + +
Sbjct: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLQDQPTRNLAAFPASHDPD 600
Query: 544 --------VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDRSSWLRQEEDIPPKVPQRTTS 594
S R + RQNSDPTSE P P P + +W+R + + PPKVPQRT+S
Sbjct: 601 PAIPAPTATPSARGAVIRQNSDPTSEGPGPSP------NPPAWVRPDNEAPPKVPQRTSS 654
Query: 595 ISPALARKNSPGNGSALG----PRLGSQ--------------------------PIRASN 624
I+ AL + G+ A PR S P +SN
Sbjct: 655 IATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSN 714
Query: 625 PDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEG 684
PDLRR++P E S S P+S G P QAGS ER RV +SK +
Sbjct: 715 PDLRRSDPGWER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDS 757
Query: 685 SPVLPHEPAKVKPEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEES 744
SPVL K KP++ R +RP RPAD L +E ++E RP KK DYSSSSEE
Sbjct: 758 SPVLS-PGNKAKPDDHR--SRPGRPADFVLL----KERTLDEAPRPPKKAMDYSSSSEEV 810
Query: 745 ESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSFS 802
ESSE++EE+GE +G+ D P G + +V + H +E T +
Sbjct: 811 ESSEDDEEEGEGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPYG 862
Query: 803 GSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHS 862
G GT++++ T E++ H+DSNG+ NLPD+VQ SHSP TE S S
Sbjct: 863 G-----GTMVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPPS 910
Query: 863 QEMDSGTEYGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQ 919
++ SG G + K+SFT FVD +YQ + + AL E R +Q
Sbjct: 911 KD-GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLDQ 964
Query: 920 AKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLL 979
+ + RK SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLL
Sbjct: 965 LQY-DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLL 1023
Query: 980 DRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEK 1039
DRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVEK
Sbjct: 1024 DRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEK 1083
Query: 1040 KQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHK 1099
KQGW TVGD+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H+
Sbjct: 1084 KQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHR 1143
Query: 1100 PLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDG 1159
PLLVDLTVEEGQRLKVI+GS GFH +DVDSGNSYDIYIP HIQ ITPHAI+ LP TDG
Sbjct: 1144 PLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDG 1203
Query: 1160 MEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGH 1219
MEML+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETGH
Sbjct: 1204 MEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGH 1263
Query: 1220 LDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1268
LDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1264 LDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1312
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 1587 bits (4108), Expect = 0.0
Identities = 872/1359 (64%), Positives = 997/1359 (73%), Gaps = 155/1359 (11%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
Query: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
Query: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
QE+EQ+R E+ +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE YL SLQ
Sbjct: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
Query: 476 HQ-------RQEQ---------------------------RPVEKK---------PLYHY 492
Q +Q+Q R VE++ PL
Sbjct: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Query: 493 KEGMS---------------------PSEKPAWAKEIPHL------VAVKSQGPALTASQ 525
K G + P ++P +E PH V +K + SQ
Sbjct: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
Query: 526 SVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDR 574
S+ +QPT+ L+ F + + S R + RQNSDPTSE P P P +
Sbjct: 601 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP------NP 654
Query: 575 SSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPIL 634
+W+R + + PPKVPQRT+SI+ AL N S G +Q +RASNPDLRR++P
Sbjct: 655 PAWVRPDNEAPPKVPQRTSSIATAL-------NTSGAGGSRPAQAVRASNPDLRRSDPGW 707
Query: 635 ESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAK 694
E S S P+S G P QAGS ER RV +SK + SPVL K
Sbjct: 708 ER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDSSPVLS-PGNK 749
Query: 695 VKPEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDG 754
KP++ R +RP RPAD L +E ++E RP KK DYSSSSEE ESSE++EE+G
Sbjct: 750 AKPDDHR--SRPGRPADFVLL----KERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG 803
Query: 755 ESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSFSGSISREGTLM 812
E +G+ D P G + +V + H +E T + G GT++
Sbjct: 804 EGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPYGG-----GTMV 850
Query: 813 IRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYG 872
++ T E++ H+DSNG+ NLPD+VQ SHSP TE S S++ SG
Sbjct: 851 VQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPPSKD-GSGDYQS 902
Query: 873 MG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKIS 929
G + K+SFT FVD +YQ + + AL E R +Q + + RK S
Sbjct: 903 RGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLDQLQY-DVRKGS 956
Query: 930 VVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYN 989
VVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY
Sbjct: 957 VVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYG 1016
Query: 990 LINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDL 1049
LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVEKKQGW TVGD+
Sbjct: 1017 LIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDM 1076
Query: 1050 EGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEE 1109
EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H+PLLVDLTVEE
Sbjct: 1077 EGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEE 1136
Query: 1110 GQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDE 1169
GQRLKVI+GS GFH +DVDSGNSYDIYIP HIQ ITPHAI+ LP TDGMEML+CYEDE
Sbjct: 1137 GQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDE 1196
Query: 1170 GVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRA 1229
GVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETGHLDGVFMHKRA
Sbjct: 1197 GVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRA 1256
Query: 1230 QRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1268
QRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1257 QRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1295
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 1584 bits (4101), Expect = 0.0
Identities = 872/1363 (63%), Positives = 997/1363 (73%), Gaps = 155/1363 (11%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
Query: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
Query: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
QE+EQ+R E+ +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE YL SLQ
Sbjct: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
Query: 476 HQ-------RQEQ---------------------------RPVEKK---------PLYHY 492
Q +Q+Q R VE++ PL
Sbjct: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Query: 493 KEGMS---------------------PSEKPAWAKEIPHL------VAVKSQGPALTASQ 525
K G + P ++P +E PH V +K + SQ
Sbjct: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
Query: 526 SVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDR 574
S+ +QPT+ L+ F + + S R + RQNSDPTSE P P P +
Sbjct: 601 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP------NP 654
Query: 575 SSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPIL 634
+W+R + + PPKVPQRT+SI+ AL N S G +Q +RASNPDLRR++P
Sbjct: 655 PAWVRPDNEAPPKVPQRTSSIATAL-------NTSGAGGSRPAQAVRASNPDLRRSDPGW 707
Query: 635 ESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAK 694
E S S P+S G P QAGS ER RV +SK + SPVL K
Sbjct: 708 ER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDSSPVLS-PGNK 749
Query: 695 VKPEESRDITRPSRPADLTALAKE----LRELRIEETNRPMKKVTDYSSSSEESESSEEE 750
KP++ R +RP RPA E L+E ++E RP KK DYSSSSEE ESSE++
Sbjct: 750 AKPDDHR--SRPGRPASYKRAIGEDFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDD 807
Query: 751 EEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSFSGSISRE 808
EE+GE +G+ D P G + +V + H +E T + G
Sbjct: 808 EEEGEGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPYGG----- 854
Query: 809 GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 868
GT++++ T E++ H+DSNG+ NLPD+VQ SHSP TE S S++ SG
Sbjct: 855 GTMVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPPSKD-GSG 906
Query: 869 TEYGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEA 925
G + K+SFT FVD +YQ + + AL E R +Q + +
Sbjct: 907 DYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLDQLQY-DV 960
Query: 926 RKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQG 985
RK SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQG
Sbjct: 961 RKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQG 1020
Query: 986 KVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWIT 1045
KVY LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVEKKQGW T
Sbjct: 1021 KVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTT 1080
Query: 1046 VGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDL 1105
VGD+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H+PLLVDL
Sbjct: 1081 VGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDL 1140
Query: 1106 TVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVC 1165
TVEEGQRLKVI+GS GFH +DVDSGNSYDIYIP HIQ ITPHAI+ LP TDGMEML+C
Sbjct: 1141 TVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLC 1200
Query: 1166 YEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFM 1225
YEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETGHLDGVFM
Sbjct: 1201 YEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFM 1260
Query: 1226 HKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1268
HKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1261 HKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1303
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 1578 bits (4087), Expect = 0.0
Identities = 872/1384 (63%), Positives = 992/1384 (71%), Gaps = 180/1384 (13%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
Query: 417 KQQEREQRRHYEEQMRR-----------------EEERRRAEHEQEYKRKQLEEQ----- 454
+QQEREQRR +E+ RR EEE+RR E EQEY R+QLEE+
Sbjct: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
Query: 455 ------------------------RQAERLQRQLKQERDYLVSLQHQRQEQRP------- 483
RQAERLQRQL+QE+ YL+SLQH + P
Sbjct: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540
Query: 484 ----VEKKPLYHYKEGMSPSEKPAWAKEIPHL-----------------------VAVKS 516
KP +H E + E A+E+ V +S
Sbjct: 541 PPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRS 600
Query: 517 QGPALTASQSVH---EQPTKGLSGFQEALNVTSHRVEMPRQN--SDPT---------SEN 562
+ + S+SVH ++P + + ++ ++ + R + SDP+ S++
Sbjct: 601 ESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQD 660
Query: 563 PPLPTRIEKFDRSS-------------WLRQEED-IPPKVPQRTTSISPALARKNSPGNG 608
P P+R E +SS W R + D +PP+VP RTTS SP L+R++SP G
Sbjct: 661 PCPPSRSEVLSQSSDSKSEAPDPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRDSPLQG 720
Query: 609 SALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQA 668
S Q S+ + R +E + R SGSSS SS SQP GS PGSQ+
Sbjct: 721 SGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP----GSHPGSQS 776
Query: 669 GSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA---DLTALAKELRELRIE 725
GS ER RVR++SKSEGSP E A KPE+ +++ RP +PA DLTALAKELR +
Sbjct: 777 GSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAV--- 833
Query: 726 ETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNV 785
E RP KVTDYSSSSEES +++EE++D E E D + + + R + + E +V
Sbjct: 834 EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESV 893
Query: 786 GMVGTHGLETSHADSFSGSISREGTLMIRET-SGEKKRSGHSDSNGFAGHINLPDLVQQS 844
+ H S + + S+EGTL++R+T S H S+ F I+ P L+Q S
Sbjct: 894 KTMIVHDDVESEP---AMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFID-PRLLQIS 949
Query: 845 HSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEES 904
S T T +G
Sbjct: 950 PSSGTTVTSVVG------------------------------------------------ 961
Query: 905 SAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALW 964
F+ + +R E + + RK SVVNVNPTN RP SDTPEIRKYKKRFNSEILCAALW
Sbjct: 962 -----FSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALW 1016
Query: 965 GVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLS 1024
GVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLEGLNVLVTISGKK+KLRVYYLS
Sbjct: 1017 GVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLS 1076
Query: 1025 WLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPY 1084
WLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERIKFLVIALK++VE+YAWAPKPY
Sbjct: 1077 WLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPY 1136
Query: 1085 HKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQG 1144
HKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS GFH +DVDSG+ YDIY+P+HIQ
Sbjct: 1137 HKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQC 1196
Query: 1145 NITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMG 1204
+I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI SNQ MG
Sbjct: 1197 SIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMG 1256
Query: 1205 WGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNS 1264
WGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTL R S
Sbjct: 1257 WGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTS 1316
Query: 1265 MMNW 1268
+++W
Sbjct: 1317 LLSW 1320
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 1577 bits (4084), Expect = 0.0
Identities = 853/1285 (66%), Positives = 964/1285 (75%), Gaps = 90/1285 (7%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
Query: 417 KQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAER----LQRQLKQERDYLV 472
+QQEREQRR +E+ RR EE R E+E +R+ EE+R+ ER ++RQL++E+ +L
Sbjct: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
Query: 473 SLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPT 532
LQ Q +++ + L H P +++ P +S+ H +P
Sbjct: 481 VLQQQLLQEQAM----LLHDHRRPHPQH----SQQPPPPQQERSKPSFHAPEPKAHYEPA 532
Query: 533 KGLSGFQEALNVTSHRVEMPRQNSDPTSE--NPPLPTRIEKFDR----SSWLRQEEDIPP 586
++ T+H P S T PP+P+R E F S + P
Sbjct: 533 DRAREVEDRFRKTNH--SSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEP 590
Query: 587 KVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSS 646
+VP RTTS SP L+R++SP GS Q S+ + R +E + R SGSS
Sbjct: 591 QVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSS 650
Query: 647 SSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRP 706
S SS SQP GS PGSQ+GS ER RVR++SKSEGSP E A KPE+ +++ RP
Sbjct: 651 SGSSNSGSQP----GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRP 706
Query: 707 SRPA---DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTV 763
+PA DLTALAKELR + E RP KVTDYSSSSEES +++EE++D E E
Sbjct: 707 LKPAGEVDLTALAKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQE------ 757
Query: 764 AVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRS 823
G++E T G E + A S L ET K
Sbjct: 758 --------------GADES-------TSGPEDTRAASSLN-------LSNGETESVKTMI 789
Query: 824 GHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTP 883
H D PA TP++ + +Q S + SS SFTP
Sbjct: 790 VHDDVES---------------EPAMTPSKEGTLIVRQTQSASSTLQKHKSSS---SFTP 831
Query: 884 FVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSD 943
F+DPR+ Q SP+ ++ F+ + +R E + + RK SVVNVNPTN RP SD
Sbjct: 832 FIDPRLLQISPSS----GTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSD 887
Query: 944 TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLE 1003
TPEIRKYKKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLE
Sbjct: 888 TPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLE 947
Query: 1004 GLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERI 1063
GLNVLVTISGKK+KLRVYYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERI
Sbjct: 948 GLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERI 1007
Query: 1064 KFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGF 1123
KFLVIALK++VE+YAWAPKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS GF
Sbjct: 1008 KFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGF 1067
Query: 1124 HVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDV 1183
H +DVDSG+ YDIY+P+HIQ +I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRITKDV
Sbjct: 1068 HAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDV 1127
Query: 1184 VLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVF 1243
VLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVF
Sbjct: 1128 VLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVF 1187
Query: 1244 FASVRSGGSSQVFFMTLNRNSMMNW 1268
FASVRSGGSSQV+FMTL R S+++W
Sbjct: 1188 FASVRSGGSSQVYFMTLGRTSLLSW 1212
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 1572 bits (4070), Expect = 0.0
Identities = 872/1389 (62%), Positives = 998/1389 (71%), Gaps = 178/1389 (12%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
Query: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
Query: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
QE+EQ+R E+ +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE YL SLQ
Sbjct: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
Query: 476 HQ-------RQEQ---------------------------RPVEKK---------PLYHY 492
Q +Q+Q R VE++ PL
Sbjct: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Query: 493 KEGMS---------------------PSEKPAWAKEIPHL------VAVKSQGPALTASQ 525
K G + P ++P +E PH V +K + SQ
Sbjct: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
Query: 526 SVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDR 574
S+ +QPT+ L+ F + + S R + RQNSDPTSE P P P +
Sbjct: 601 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP------NP 654
Query: 575 SSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALG----PRLGSQ------------ 618
+W+R + + PPKVPQRT+SI+ AL + G+ A PR S
Sbjct: 655 PAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERG 714
Query: 619 --------------PIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQP 664
P +SNPDLRR++P E S S P+S G P
Sbjct: 715 TPKPPGPPAQPPGPPNASSNPDLRRSDPGWER----------SDSVLPASH-----GHLP 759
Query: 665 GSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELRELRI 724
QAGS ER RV +SK + SPVL K KP++ R +RP RPAD L +E +
Sbjct: 760 --QAGSLERNRVGVSSKPDSSPVLS-PGNKAKPDDHR--SRPGRPADFVLL----KERTL 810
Query: 725 EETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYN 784
+E RP KK DYSSSSEE ESSE++EE+GE +G+ D P G + +
Sbjct: 811 DEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGS---RDTP-----GGRSDGDTDS 862
Query: 785 VGMVGTHGLE--TSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQ 842
V + H +E T + G GT++++ T E++ H+DSNG+ NLPD+VQ
Sbjct: 863 VSTMVVHDVEEITGTQPPYGG-----GTMVVQRTPEEERNLLHADSNGYT---NLPDVVQ 914
Query: 843 QSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMG---SSTKASFTPFVDPRVYQTSPTDEDE 899
SHSP TE S S++ SG G + K+SFT FVD +YQ + +
Sbjct: 915 PSHSP----TENSKGQSPPSKD-GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS- 968
Query: 900 EDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEIL 959
AL E R +Q + + RK SVVNVNPTN R HS+TPEIRKYKKRFNSEIL
Sbjct: 969 ----IPITALVGGEGTRLDQLQY-DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEIL 1023
Query: 960 CAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLR 1019
CAALWGVNLLVGTENGLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK+NKLR
Sbjct: 1024 CAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLR 1083
Query: 1020 VYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAW 1079
VYYLSWLRN+ILHNDPEVEKKQGW TVGD+EGC HY+VVKYERIKFLVIALK++VE+YAW
Sbjct: 1084 VYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAW 1143
Query: 1080 APKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIP 1139
APKPYHKFMAFKSFADL H+PLLVDLTVEEGQRLKVI+GS GFH +DVDSGNSYDIYIP
Sbjct: 1144 APKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIP 1203
Query: 1140 SHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHS 1199
HIQ ITPHAI+ LP TDGMEML+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI S
Sbjct: 1204 VHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICS 1263
Query: 1200 NQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMT 1259
NQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMT
Sbjct: 1264 NQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMT 1323
Query: 1260 LNRNSMMNW 1268
LNRN +MNW
Sbjct: 1324 LNRNCIMNW 1332
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 1536 bits (3978), Expect = 0.0
Identities = 837/1288 (64%), Positives = 946/1288 (73%), Gaps = 142/1288 (11%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
Query: 417 KQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAER----LQRQLKQERDYLV 472
+QQEREQRR +E+ RR EE R E+E +R+ EE+R+ ER ++RQL++E+ +L
Sbjct: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
Query: 473 SLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPT 532
LQ Q +++ + L H P +QP
Sbjct: 481 VLQQQLLQEQAM----LLHDHRRPHPQHS---------------------------QQPP 509
Query: 533 KGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRT 592
++ S P+ P E DR+ +VP RT
Sbjct: 510 PP-----------------QQERSKPSFHAPEPKAHYEPADRAR----------EVPVRT 542
Query: 593 TSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTP 652
TS SP L+R++SP GS Q S+ + R +E + R SGSSS SS
Sbjct: 543 TSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNS 602
Query: 653 SSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA-- 710
SQP GS PGSQ+GS ER RVR++SKSEGSP E A KPE+ +++ RP +PA
Sbjct: 603 GSQP----GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGE 658
Query: 711 -DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIP 769
DLTALAKELR + E RP KVTDYSSSSEES +++EE++D E E D + + +
Sbjct: 659 VDLTALAKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDT 715
Query: 770 RLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET-SGEKKRSGHSDS 828
R + + E +V + H S + + S+EGTL++R+T S H S
Sbjct: 716 RAASSLNLSNGETESVKTMIVHDDVESEP---AMTPSKEGTLIVRQTQSASSTLQKHKSS 772
Query: 829 NGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPR 888
+ F I+ P L+Q S S T T +G
Sbjct: 773 SSFTPFID-PRLLQISPSSGTTVTSVVG-------------------------------- 799
Query: 889 VYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIR 948
F+ + +R E + + RK SVVNVNPTN RP SDTPEIR
Sbjct: 800 ---------------------FSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIR 838
Query: 949 KYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVL 1008
KYKKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLEGLNVL
Sbjct: 839 KYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVL 898
Query: 1009 VTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVI 1068
VTISGKK+KLRVYYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERIKFLVI
Sbjct: 899 VTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVI 958
Query: 1069 ALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDV 1128
ALK++VE+YAWAPKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS GFH +DV
Sbjct: 959 ALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDV 1018
Query: 1129 DSGNSYDIYIPSHIQGN--------ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRIT 1180
DSG+ YDIY+P+H++ N I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRIT
Sbjct: 1019 DSGSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRIT 1078
Query: 1181 KDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERND 1240
KDVVLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERND
Sbjct: 1079 KDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERND 1138
Query: 1241 KVFFASVRSGGSSQVFFMTLNRNSMMNW 1268
KVFFASVRSGGSSQV+FMTL R S+++W
Sbjct: 1139 KVFFASVRSGGSSQVYFMTLGRTSLLSW 1166
>gi|118600963 Nik related kinase [Homo sapiens]
Length = 1582
Score = 400 bits (1028), Expect = e-111
Identities = 250/704 (35%), Positives = 366/704 (51%), Gaps = 102/704 (14%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT- 59
MA R + DL L DP GIF L + +G GTYG++Y G H KTG A+KVM+
Sbjct: 1 MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK 60
Query: 60 -----------------------GDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPG 96
DEEE+++ E+N+L+KYS H+NI ++YGAF K +PPG
Sbjct: 61 TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG 120
Query: 97 MDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKG 156
QLW+VME C AGSVTD+++ T +LKE+WIAYICREIL+GL+HLH H+VIHRDIKG
Sbjct: 121 QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG 180
Query: 157 QNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDL 216
QNVLLT NAEVKLVDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P +YD++SD+
Sbjct: 181 QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV 240
Query: 217 WSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQ 276
WS+GITAIEMAEGAPPLC++ P+ ALF+I R AP +KS WS+KF +F+E C +KN
Sbjct: 241 WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF 300
Query: 277 RPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDET---EYEYSGSEEEEEEN 333
RP + +++HPF+RD NER V L H+ KKR +K E E + E+
Sbjct: 301 RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR 360
Query: 334 DSGEPS---SILNLPGESTLR---------------------------------RDFLRL 357
G PS +L LP S R R F+ L
Sbjct: 361 FRG-PSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAARVFMPL 419
Query: 358 QLAN------KERSEALRRQQ--------LEQQQRENEEHKRQLLAERQKRIEEQKEQRR 403
Q + K +++A +R Q L+ Q + Q+ + R+
Sbjct: 420 QALDSAPKPLKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAARVLM 479
Query: 404 RLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQ 463
L+ Q R + L+ Q + +++ + Q ++ + E + + + E+QRQ + ++Q
Sbjct: 480 PLQAQVRAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQGQAPEQQ 539
Query: 464 LKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAK----------------- 506
+ + L+ + ++P ++ + + +E+P +
Sbjct: 540 QRHNQVPEQELEQNQAPEQPEVQEQAAEPAQAETEAEEPESLRVNAQVFLPLLSQDHHVL 599
Query: 507 -----EIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSE 561
+ L+ V+ Q +Q+ +P + + Q + S R + NS+ +
Sbjct: 600 LPLHLDTQVLIPVEGQTEGSPQAQAWTLEPPQAIGSVQALIEGLS-RDLLRAPNSNNSKP 658
Query: 562 NPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 605
PL T +E + + Q E K + +++ ALA++ SP
Sbjct: 659 LGPLQTLMENLSSNRFYSQPEQAREK-KSKVSTLRQALAKRLSP 701
Score = 274 bits (701), Expect = 3e-73
Identities = 152/416 (36%), Positives = 233/416 (56%), Gaps = 58/416 (13%)
Query: 905 SAAALFTSELLRQEQAKLNEA--RKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAA 962
SA A F S +L ++ E ++ S VNVNP + P P I Y+K F SEI C +
Sbjct: 1157 SADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPLIHMYEKEFTSEICCGS 1216
Query: 963 LWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYY 1022
LWGVNLL+GT + L L+DRSG+ + LI RR F+Q+ VLE LN+L+TISG KN+LRVY+
Sbjct: 1217 LWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVYH 1276
Query: 1023 LSWLRNRILHNDPEVEKKQGWI--------TVGDLEGCIHYKVVKYERIKFLVIALKNAV 1074
L+WLRN+IL+NDPE +++Q + + L GC H+ V+++E ++ IALK+++
Sbjct: 1277 LTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAIALKSSI 1336
Query: 1075 EIYAWAPK---------------------------------------PYHKF-------- 1087
+YAWAPK P ++F
Sbjct: 1337 HLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKRPDELLH 1396
Query: 1088 -MAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNI 1146
+ K F L HKP+ VDL + +RLK+ F S G+H+ID +S D+ +P + I
Sbjct: 1397 LLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPKNPLEII 1456
Query: 1147 TPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWG 1206
P I+ILP G+ M++ + E + V ++ K ++ W ++P+S+A+ + + GWG
Sbjct: 1457 IPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRTTGWG 1516
Query: 1207 EKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNR 1262
+KAIE+RS+++ L+ + ++L+FLC R DK+FF S S+V+FMTL +
Sbjct: 1517 QKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGK 1572
Score = 37.0 bits (84), Expect = 0.12
Identities = 36/168 (21%), Positives = 71/168 (42%), Gaps = 16/168 (9%)
Query: 350 LRRDFLRLQLANKERS--------EALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQ 401
L RD LR +N + E L + Q + E K ++ RQ + +
Sbjct: 643 LSRDLLRAPNSNNSKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLSPK 702
Query: 402 RRRLEEQQRREK----ELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQA 457
R R + R EK +L +++R QRR + + EEE R+ + ++E + +E +
Sbjct: 703 RFRAKSSWRPEKLELSDLEARRQRRQRRWEDIFNQHEEELRQVDKDKEDESSDNDEVFHS 762
Query: 458 ERLQRQLKQERDYLVSLQ----HQRQEQRPVEKKPLYHYKEGMSPSEK 501
+ + Q++ + Y+ + + +R P + +H K S ++
Sbjct: 763 IQAEVQIEPLKPYISNPKKIEVQERSPSVPNNQDHAHHVKFSSSVPQR 810
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 306 bits (785), Expect = 6e-83
Identities = 155/311 (49%), Positives = 207/311 (66%), Gaps = 11/311 (3%)
Query: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHH 79
DP+ +E+ E +G GTYG+V+K + K GQ AA+K++D D +EEI+ E N+LK S H
Sbjct: 16 DPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEAEYNILKALSDH 75
Query: 80 RNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKN--TKGNTLKEEWIAYICREI 137
N+ +YG + KK+ D+LWLV+E C GSVTDL+K +G + E IAYI E
Sbjct: 76 PNVVRFYGIYFKKDKVN-GDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEA 134
Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L GL HLH +K IHRD+KG N+LLT VKLVDFGVSAQL T RRNT +GTP+WMAP
Sbjct: 135 LMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAP 194
Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
EVIAC++ D TYD + D WSLGITAIE+ +G PPL D+HPMRALF IPRNP P+L+ +
Sbjct: 195 EVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPE 254
Query: 258 -WSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-----RDQPNERQVR--IQLKDHIDRT 309
WS +F FI CL K++ +RP +L++H FI +D ++Q+ I + + T
Sbjct: 255 LWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGKDVMLQKQLTEFIGIHQCMGGT 314
Query: 310 KKKRGEKDETE 320
+K R E+ T+
Sbjct: 315 EKARRERIHTK 325
Score = 33.1 bits (74), Expect = 1.7
Identities = 44/211 (20%), Positives = 83/211 (39%), Gaps = 28/211 (13%)
Query: 281 EQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSS 340
E+ +K F P + +KD + + ++ EK+E + EE N ++
Sbjct: 1197 EEEVKQEFYLVGPEVSPKQKSVKDLEENSNLRKVEKEEAMIQSYYQRYTEERNCEESKAA 1256
Query: 341 ILNLPGESTLRRDFLRLQLANKERS------EALRRQQLEQQQRENEEHKRQLLAERQKR 394
L S R + LA E S L ++ + Q E+ K+ + ++
Sbjct: 1257 YLERKAISE-RPSYPVPWLAENETSFKKTLEPTLSQRSIYQNANSMEKEKKTSVVTQRAP 1315
Query: 395 IEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQ 454
I Q+E R RL RH + R+ E +A+ E++ ++ +
Sbjct: 1316 ICSQEEGRGRL-------------------RHETVKERQVEPVTQAQEEEDKAAVFIQSK 1356
Query: 455 RQAERLQRQLKQERDYLVSLQHQRQEQRPVE 485
+ + ++QL+ +D + S +HQR P E
Sbjct: 1357 YRGYKRRQQLR--KDKMSSFKHQRIVTTPTE 1385
>gi|134288915 myosin IIIB isoform 1 [Homo sapiens]
Length = 1314
Score = 296 bits (758), Expect = 8e-80
Identities = 152/328 (46%), Positives = 211/328 (64%), Gaps = 11/328 (3%)
Query: 13 IDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINM 72
+ L +L DP +E++E +G GTYG+VYK + + G LAA+K++D D +EEI+ E N+
Sbjct: 15 LGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNI 74
Query: 73 LKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTK--GNTLKEEWI 130
L+ +H N+ +YG F K + + QLWLV+E C GSVT+L+K G L E I
Sbjct: 75 LQFLPNHPNVVKFYGMFYKADHC-VGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMI 133
Query: 131 AYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIG 190
+YI L GL HLH +++IHRD+KG N+LLT VKLVDFGVSAQL T RRNT +G
Sbjct: 134 SYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVG 193
Query: 191 TPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPA 250
TP+WMAPEVIAC++ D++YD + D+WSLGITAIE+ +G PPL DMHP++ LF IPRNP
Sbjct: 194 TPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPP 253
Query: 251 PR-LKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPN-----ERQVRIQLKD 304
P L +KW ++F FI CL+K+ +RP+ L+ HPFI+ ++Q+ L+D
Sbjct: 254 PTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQD 313
Query: 305 --HIDRTKKKRGEKDETEYEYSGSEEEE 330
H + K R E+ T Y + E+
Sbjct: 314 QKHQNPVAKTRHERMHTRRPYHVEDAEK 341
>gi|134288892 myosin IIIB isoform 2 [Homo sapiens]
Length = 1341
Score = 296 bits (758), Expect = 8e-80
Identities = 152/328 (46%), Positives = 211/328 (64%), Gaps = 11/328 (3%)
Query: 13 IDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINM 72
+ L +L DP +E++E +G GTYG+VYK + + G LAA+K++D D +EEI+ E N+
Sbjct: 15 LGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNI 74
Query: 73 LKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTK--GNTLKEEWI 130
L+ +H N+ +YG F K + + QLWLV+E C GSVT+L+K G L E I
Sbjct: 75 LQFLPNHPNVVKFYGMFYKADHC-VGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMI 133
Query: 131 AYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIG 190
+YI L GL HLH +++IHRD+KG N+LLT VKLVDFGVSAQL T RRNT +G
Sbjct: 134 SYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVG 193
Query: 191 TPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPA 250
TP+WMAPEVIAC++ D++YD + D+WSLGITAIE+ +G PPL DMHP++ LF IPRNP
Sbjct: 194 TPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPP 253
Query: 251 PR-LKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPN-----ERQVRIQLKD 304
P L +KW ++F FI CL+K+ +RP+ L+ HPFI+ ++Q+ L+D
Sbjct: 254 PTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQD 313
Query: 305 --HIDRTKKKRGEKDETEYEYSGSEEEE 330
H + K R E+ T Y + E+
Sbjct: 314 QKHQNPVAKTRHERMHTRRPYHVEDAEK 341
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 273 bits (698), Expect = 8e-73
Identities = 164/417 (39%), Positives = 236/417 (56%), Gaps = 25/417 (5%)
Query: 6 PARSLDEIDLSAL-RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEE 64
P R L ++D +L + P +F+++E +G G+YG VYK H +TGQ+ AIK + V D +E
Sbjct: 10 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69
Query: 65 EIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNT 124
IK+ M + S H + YYG++ K LW+VME+CGAGSV+D+I+ + T
Sbjct: 70 IIKEISIMQQCDSPH--VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120
Query: 125 LKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
L E+ IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T+ +
Sbjct: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
Query: 185 RNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFL 244
RNT IGTP+WMAPEVI + Y+ +D+WSLGITAIEMAEG PP D+HPMRA+F+
Sbjct: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
Query: 245 IPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLK 303
IP NP P K + WS F F++ CLVK+ QR QL++HPF+R +R +
Sbjct: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLIN 295
Query: 304 DHIDRTKKKRGEKDETEYEYSGSE-EEEEENDSGEPSSILNLPGE--STLRRDFLRLQLA 360
+ +D K KR E + E + E EE+E DSG +++ G+ T+R A
Sbjct: 296 EAMD-VKLKRQESQQREVDQDDEENSEEDEMDSG---TMVRAVGDEMGTVRVASTMTDGA 351
Query: 361 NK--ERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKEL 415
N E + L Q +E + + R + ++ K EQ+ +E ++
Sbjct: 352 NTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQI 408
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 266 bits (679), Expect = 1e-70
Identities = 141/297 (47%), Positives = 197/297 (66%), Gaps = 15/297 (5%)
Query: 14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINML 73
DLS R+P FEL++ +G+GTYG VYK R+V TG+LAAIKV+ + E+ + Q+ ++
Sbjct: 6 DLSR-RNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIM 64
Query: 74 KKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYI 133
K H NI Y+G+++++ D+LW+ MEFCG GS+ D+ T L E IAY+
Sbjct: 65 MKDCKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYV 116
Query: 134 CREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
RE L+GL +LH +HRDIKG N+LLT+N VKL DFGVSAQ+ T+ +R +FIGTPY
Sbjct: 117 SRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPY 176
Query: 194 WMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAP 251
WMAPEV A + Y+ DLW++GITAIE+AE PP+ D+HPMRALFL+ ++ P
Sbjct: 177 WMAPEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPP 234
Query: 252 RLKSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHID 307
+LK K KWS F F++ L KN +RP E+L++HPF+ Q R + I+L D ++
Sbjct: 235 KLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV-TQHLTRSLAIELLDKVN 290
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 263 bits (672), Expect = 8e-70
Identities = 149/369 (40%), Positives = 224/369 (60%), Gaps = 38/369 (10%)
Query: 19 RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKYS 77
R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + GD+ I+QEI M+K+
Sbjct: 14 RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73
Query: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T L E IAY+CRE
Sbjct: 74 HC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRET 124
Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL++LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+ +R +FIGTPYWMAP
Sbjct: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 255
EV A ++N Y+ D+W++GITAIE+ E PP+ D+HPMRALFL+ ++ P+LK
Sbjct: 185 EVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242
Query: 256 K-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314
K KWS F +F++ L KN +RP E+L+ H F+ R + ++L D ++
Sbjct: 243 KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN------- 295
Query: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRR----------DFLRLQLANKER 364
+ Y+ E ++D EP +I+ ST R +F +LQ R
Sbjct: 296 -NPDNHAHYT-----EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLR 349
Query: 365 SEALRRQQL 373
E R ++
Sbjct: 350 KETEARDEM 358
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 263 bits (672), Expect = 8e-70
Identities = 149/369 (40%), Positives = 224/369 (60%), Gaps = 38/369 (10%)
Query: 19 RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKYS 77
R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + GD+ I+QEI M+K+
Sbjct: 14 RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73
Query: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T L E IAY+CRE
Sbjct: 74 HC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRET 124
Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL++LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+ +R +FIGTPYWMAP
Sbjct: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 255
EV A ++N Y+ D+W++GITAIE+ E PP+ D+HPMRALFL+ ++ P+LK
Sbjct: 185 EVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242
Query: 256 K-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314
K KWS F +F++ L KN +RP E+L+ H F+ R + ++L D ++
Sbjct: 243 KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN------- 295
Query: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRR----------DFLRLQLANKER 364
+ Y+ E ++D EP +I+ ST R +F +LQ R
Sbjct: 296 -NPDNHAHYT-----EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLR 349
Query: 365 SEALRRQQL 373
E R ++
Sbjct: 350 KETEARDEM 358
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 260 bits (665), Expect = 5e-69
Identities = 149/338 (44%), Positives = 208/338 (61%), Gaps = 24/338 (7%)
Query: 2 ASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGD 61
A S + L E L+ + P +F+++E +G G+YG V+K H ++GQ+ AIK + V D
Sbjct: 6 APKSKLKKLSEDSLT--KQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD 63
Query: 62 EEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTK 121
+E IK EI+++++ + YYG++ K LW+VME+CGAGSV+D+I+ +
Sbjct: 64 LQEIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LR 114
Query: 122 GNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
TL E+ IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T
Sbjct: 115 NKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDT 174
Query: 182 VGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA 241
+ +RNT IGTP+WMAPEVI + Y+ +D+WSLGIT+IEMAEG PP D+HPMRA
Sbjct: 175 MAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRA 229
Query: 242 LFLIPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
+F+IP NP P K + WS F F++ CLVKN QR QL++HPFI+ N + V I
Sbjct: 230 IFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK---NAKPVSI 286
Query: 301 QLKDHIDRT---KKKRGEKDETEYEYSGSEEEEEENDS 335
L+D I K KR E+ + E E +E+E DS
Sbjct: 287 -LRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDS 323
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 259 bits (663), Expect = 9e-69
Identities = 142/319 (44%), Positives = 202/319 (63%), Gaps = 19/319 (5%)
Query: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77
DP +F ++ +G G++G+VYKG T ++ AIK++D+ DE E+I+QEI +L +
Sbjct: 15 DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
Query: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
I Y+G+++K +LW++ME+ G GS DL+K L+E +IA I REI
Sbjct: 75 SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124
Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH + IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184
Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
EVI + YDFK+D+WSLGITAIE+A+G PP D+HPMR LFLIP+N P L+ +
Sbjct: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239
Query: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
SK F+ F+E+CL K+ RP ++L+KH FI + +L D R K + G +
Sbjct: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSE-GHGE 297
Query: 318 ETEYEYSGSEEEEEENDSG 336
E+ E S + E E+ + G
Sbjct: 298 ESSSEDSDIDGEAEDGEQG 316
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 259 bits (661), Expect = 1e-68
Identities = 141/320 (44%), Positives = 201/320 (62%), Gaps = 18/320 (5%)
Query: 18 LRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKK 75
+ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ DE E+I+QEI +L +
Sbjct: 17 IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76
Query: 76 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
+ YYG+++K + +LW++ME+ G GS DL++ E IA + +
Sbjct: 77 CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126
Query: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
EIL+GL +LH K IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WM
Sbjct: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186
Query: 196 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS 255
APEVI + YD K+D+WSLGITAIE+A+G PP DMHPMR LFLIP+N P L
Sbjct: 187 APEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG 241
Query: 256 KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315
++K F+ FI++CL K+ S RP ++L+KH FI + +L D R K +
Sbjct: 242 -DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300
Query: 316 KDETEYEYSGSEEEEEENDS 335
DE++ E S SE EN++
Sbjct: 301 DDESDSEGSDSESTSRENNT 320
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 255 bits (652), Expect = 2e-67
Identities = 218/827 (26%), Positives = 366/827 (44%), Gaps = 90/827 (10%)
Query: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE-EEIKQEINMLKKYSH 78
+P +E++ +G+G +G+VYK ++ +T LAA KV+D +EE E+ EI++L H
Sbjct: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88
Query: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
NI AF +N LW+++EFC G+V D + L E I +C++ L
Sbjct: 89 P-NIVKLLDAFYYEN------NLWILIEFCAGGAV-DAVMLELERPLTESQIQVVCKQTL 140
Query: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
L++LH +K+IHRD+K N+L T + ++KL DFGVSA+ RT+ RR++FIGTPYWMAPE
Sbjct: 141 DALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPE 200
Query: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRL-KSKK 257
V+ C+ + D YD+K+D+WSLGIT IEMAE PP +++PMR L I ++ P L + +
Sbjct: 201 VVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSR 260
Query: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
WS F+ F++ CL KN R T QL++HPF+ N+ +++ I K +
Sbjct: 261 WSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNK-----PIRELIAEAK-----AE 310
Query: 318 ETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKE-----RSEALRRQQ 372
TE G EE+EEE E + L +P D L +A+ E ++ +
Sbjct: 311 VTEEVEDGKEEDEEE----ETENSLPIPASKRASSD---LSIASSEEDKLSQNACILESV 363
Query: 373 LEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMR 432
E+ +R N E K +K ++ E+ + + +L E R ++
Sbjct: 364 SEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENE 423
Query: 433 REEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHY 492
RE+ + ++ ++ +E + + + + + +E++ EK+ ++
Sbjct: 424 REKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFEN 483
Query: 493 KEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMP 552
K S K + + + + G Q+V + QE L E
Sbjct: 484 KLIKSEEIKDTILQTVD--LVSQETGEKEANIQAVDSEVGLTKEDTQEKLG------EDD 535
Query: 553 RQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALG 612
+ D S + E D V Q+ S + N +G
Sbjct: 536 KTQKDVISNTSDVIGTCEAAD--------------VAQKVDEDSAEDTQSNDGKEVVEVG 581
Query: 613 PRLGSQPIRASNPDLRRTEPILE-SPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSS 671
+L ++P+ + PI E + G + + SS+ +PG+ G
Sbjct: 582 QKLINKPMVGPEAGGTKEVPIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEG-E 640
Query: 672 ERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELRELRIEETNRPM 731
E T + + E V+ K E +D ++ + T + KE +E+ + P
Sbjct: 641 EITESSSTEEMEVRSVVADTDQKALGSEVQDASKVT-----TQIDKEKKEIPVSIKKEP- 694
Query: 732 KKVTDYSSSSE-----------ESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSN 780
+VT S +E S+S E +EE G ++S ++P +
Sbjct: 695 -EVTVVSQPTEPQPVLIPSININSDSGENKEEIG---------SLSKTETILPPESENPK 744
Query: 781 EQYNVGMVGTHGLETSHAD------SFSGSISREGTLMIRETSGEKK 821
E N G+ +TS D SF G++ ++ET +KK
Sbjct: 745 ENDNDSGTGSTA-DTSSIDLNLSISSFLSKTKDSGSISLQETRRQKK 790
Score = 49.3 bits (116), Expect = 2e-05
Identities = 44/192 (22%), Positives = 88/192 (45%), Gaps = 31/192 (16%)
Query: 350 LRRDFLRLQLANKERSEALRRQQLEQQ-QRENEEHKRQLLAERQKRIEEQKEQRRRLEEQ 408
LRR LR +L ++ E +QQL + Q++ E+ R+ E + + ++ LE+Q
Sbjct: 826 LRRQELR-ELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQ 884
Query: 409 QRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYK-----------------RKQL 451
Q++ E +Q+ + R ++++ E+E+ ++ + K RK+L
Sbjct: 885 QKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKEL 944
Query: 452 EEQRQAERLQRQLKQERDYLVS------------LQHQRQEQRPVEKKPLYHYKEGMSPS 499
++R+ E Q Q QE++++ +Q Q+ E +E++ L + ++ M
Sbjct: 945 MKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAR 1004
Query: 500 EKPAWAKEIPHL 511
E W E HL
Sbjct: 1005 EAAIWELEERHL 1016
Score = 47.8 bits (112), Expect = 7e-05
Identities = 54/232 (23%), Positives = 102/232 (43%), Gaps = 20/232 (8%)
Query: 262 FQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEY 321
F+ F + + K E L K + E++ +L+D R K ++ EK+ +++
Sbjct: 860 FRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQ-EKELSKF 918
Query: 322 EYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQ--------- 372
+ ++E + E + L E RR Q + + E +++QQ
Sbjct: 919 QNMLKNRKKEVINEVEKAP-KELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKK 977
Query: 373 -LEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK-ELRKQQEREQRRHYEEQ 430
++QQ+ E +R+ L +Q+ + ++ LEE+ +EK +L KQQ ++Q Q
Sbjct: 978 IIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQ 1037
Query: 431 MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQR 482
+ + HE+E ++ Q QR E L+ + QER L +Q + R
Sbjct: 1038 LLK-------RHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTR 1082
Score = 45.8 bits (107), Expect = 3e-04
Identities = 37/145 (25%), Positives = 73/145 (50%), Gaps = 16/145 (11%)
Query: 363 ERSEALRRQQLEQ---QQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQ 419
E LRRQ+L + Q+E + ++QL ++++Q+EQ R EQ+ K+ + Q
Sbjct: 821 EELRFLRRQELRELRFLQKEEQRAQQQL----NSKLQQQREQIFRRFEQEMMSKKRQYDQ 876
Query: 420 EREQRRHYEEQMRREEERRRAEH----EQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
E E + E+Q ++ ER EH E KR + E++++ + Q LK + +++
Sbjct: 877 EIE---NLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVIN-- 931
Query: 476 HQRQEQRPVEKKPLYHYKEGMSPSE 500
+ + + K+ + KE ++ S+
Sbjct: 932 EVEKAPKELRKELMKRRKEELAQSQ 956
Score = 43.1 bits (100), Expect = 0.002
Identities = 43/177 (24%), Positives = 90/177 (50%), Gaps = 34/177 (19%)
Query: 351 RRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEE----QKEQRRRLE 406
+ L+ QL K++ R Q L++ ++E E+ +R Q+ IEE Q ++R RL
Sbjct: 1019 KHQLLKQQL--KDQYFMQRHQLLKRHEKETEQMQRY----NQRLIEELKNRQTQERARLP 1072
Query: 407 EQQRREKELRK---------------QQEREQRRHY--EEQMRREEER--RRAEHEQEYK 447
+ QR E + R Q+R++ + + +E+ R++ ER + +HE + +
Sbjct: 1073 KIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMR 1132
Query: 448 RKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEK---KPLYHYKEGMSPSEK 501
QL+ + L QL+ E+ +L+ ++H+ Q+ + +++ + L ++E + P +K
Sbjct: 1133 DLQLQCEANVREL-HQLQNEKCHLL-VEHETQKLKELDEEHSQELKEWREKLRPRKK 1187
Score = 35.4 bits (80), Expect = 0.35
Identities = 42/191 (21%), Positives = 82/191 (42%), Gaps = 26/191 (13%)
Query: 292 QPNERQVRIQLKDH--IDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGEST 349
Q + ++ QLKD + R + + + ETE ++ EE + + LP
Sbjct: 1017 QEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLP---K 1073
Query: 350 LRRDFLRLQLANKERSEALRRQQLEQQQREN------EEHKRQL---LAERQKRIEEQKE 400
++R + ++A ++S + Q R+ +E KRQ +A+ QK + ++
Sbjct: 1074 IQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRD 1133
Query: 401 QRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYK--------RKQLE 452
+ + E R +L+ ++ H ++++ +E EH QE K RK+
Sbjct: 1134 LQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDE----EHSQELKEWREKLRPRKKTL 1189
Query: 453 EQRQAERLQRQ 463
E+ A +LQ Q
Sbjct: 1190 EEEFARKLQEQ 1200
Score = 34.3 bits (77), Expect = 0.78
Identities = 55/300 (18%), Positives = 121/300 (40%), Gaps = 49/300 (16%)
Query: 254 KSKKWSKKFQSFI---------ESCLVKNHSQRPATEQLMKHPFIRD----QPNERQVRI 300
+ KK KK + FI S +V + + + ++ +R+ Q E++ +
Sbjct: 787 RQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQ 846
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
QL + + +++ + E E + ++E I NL + + L +
Sbjct: 847 QLNSKLQQQREQIFRRFEQEMMSKKRQYDQE---------IENLEKQQKQTIERLEQEHT 897
Query: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQ---QRREKELRK 417
N+ R EA R + +Q++E + + L +++ I E ++ + L ++ +R+E+ +
Sbjct: 898 NRLRDEAKRIKG--EQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQS 955
Query: 418 QQEREQRRHYEEQMRREE----------------ERRRAEHEQEYKRK------QLEEQR 455
Q +EQ ++Q + ER ++Q+ R +LEE+
Sbjct: 956 QHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERH 1015
Query: 456 QAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVK 515
E+ Q +Q +D +HQ ++ E + + Y + + K +E L ++
Sbjct: 1016 LQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQ 1075
Score = 30.8 bits (68), Expect = 8.6
Identities = 44/207 (21%), Positives = 78/207 (37%), Gaps = 22/207 (10%)
Query: 862 SQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAK 921
++E++ G E T+ S R EED+ S A + S + E++
Sbjct: 312 TEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSN 371
Query: 922 LNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDR 981
+ ++N PT +D PE K + N I A L + L + +R
Sbjct: 372 SEDKLNSKILNEKPT-----TDEPE--KAVEDINEHITDAQLEAMTELHDRTAVIKENER 424
Query: 982 SGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQ 1041
+ K+ NL + + +D+ GK+N + + L I HN E+K
Sbjct: 425 EKRPKLENLPDTEDQETVDINS------VSEGKENNIMI----TLETNIEHNLKSEEEKD 474
Query: 1042 GWITVGDLEGCIHYKVVKYERIKFLVI 1068
+ + K++K E IK ++
Sbjct: 475 -----QEKQQMFENKLIKSEEIKDTIL 496
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 253 bits (647), Expect = 6e-67
Identities = 141/317 (44%), Positives = 201/317 (63%), Gaps = 24/317 (7%)
Query: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77
DP +F +E +G G++G+V+KG +T ++ AIK++D+ DE E+I+QEI +L +
Sbjct: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 79 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128
Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH K IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188
Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
EVI + YD K+D+WSLGITAIE+A G PP ++HPM+ LFLIP+N P L+
Sbjct: 189 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 242
Query: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
+SK + F+E+CL K S RP ++L+KH FI + +L IDR K+ + E+
Sbjct: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQ- 298
Query: 318 ETEYEYSGSEEEEEEND 334
++ S SE+ + E D
Sbjct: 299 --SHDDSSSEDSDAETD 313
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 253 bits (647), Expect = 6e-67
Identities = 141/317 (44%), Positives = 201/317 (63%), Gaps = 24/317 (7%)
Query: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77
DP +F +E +G G++G+V+KG +T ++ AIK++D+ DE E+I+QEI +L +
Sbjct: 31 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 90
Query: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 91 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 140
Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH K IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 141 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 200
Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
EVI + YD K+D+WSLGITAIE+A G PP ++HPM+ LFLIP+N P L+
Sbjct: 201 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 254
Query: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
+SK + F+E+CL K S RP ++L+KH FI + +L IDR K+ + E+
Sbjct: 255 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQ- 310
Query: 318 ETEYEYSGSEEEEEEND 334
++ S SE+ + E D
Sbjct: 311 --SHDDSSSEDSDAETD 325
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 249 bits (637), Expect = 9e-66
Identities = 129/280 (46%), Positives = 184/280 (65%), Gaps = 15/280 (5%)
Query: 17 ALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKK 75
+L+DP FEL++ VG GTYG VYK R T +LAA+K++ + GD+ ++QEI +L++
Sbjct: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67
Query: 76 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
H N+ Y G++++ +D+LW+ MEFCG GS+ ++ T L+E IAY+CR
Sbjct: 68 -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118
Query: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
E L+GL HLH IHRDIKG N+LLT +VKL DFGVS +L +V +R +FIGTPYWM
Sbjct: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178
Query: 196 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRL 253
APEV A + Y+ D+W+LGITAIE+ E PPL +HPMRAL L+ ++ P+L
Sbjct: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236
Query: 254 KSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQ 292
+ K +W++ F F++ L KN +RP E+L++HPF Q
Sbjct: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ 276
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.374
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,027,393
Number of Sequences: 37866
Number of extensions: 2695751
Number of successful extensions: 69074
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1601
Number of HSP's successfully gapped in prelim test: 1677
Number of HSP's that attempted gapping in prelim test: 18073
Number of HSP's gapped (non-prelim): 19838
length of query: 1268
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1154
effective length of database: 13,930,794
effective search space: 16076136276
effective search space used: 16076136276
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.