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Search of human proteins with 239735580
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
(1352 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 2707 0.0
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 2699 0.0
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 2638 0.0
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 2630 0.0
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 2560 0.0
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 2548 0.0
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 2479 0.0
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 2476 0.0
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 1686 0.0
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 1655 0.0
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 1653 0.0
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 1641 0.0
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 1632 0.0
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 1586 0.0
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 842 0.0
gi|118600963 Nik related kinase [Homo sapiens] 412 e-114
gi|145275208 myosin IIIA [Homo sapiens] 306 7e-83
gi|134288915 myosin IIIB isoform 1 [Homo sapiens] 296 9e-80
gi|134288892 myosin IIIB isoform 2 [Homo sapiens] 296 9e-80
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 273 8e-73
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 266 1e-70
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 263 8e-70
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 263 8e-70
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 260 5e-69
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 259 9e-69
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 259 2e-68
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 253 7e-67
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 253 7e-67
gi|45439370 TAO kinase 1 [Homo sapiens] 251 3e-66
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 249 1e-65
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 2707 bits (7016), Expect = 0.0
Identities = 1352/1352 (100%), Positives = 1352/1352 (100%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
Query: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
Query: 421 REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480
REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL
Sbjct: 421 REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480
Query: 481 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 540
EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER
Sbjct: 481 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 540
Query: 541 SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 600
SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS
Sbjct: 541 SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 600
Query: 601 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 660
QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS
Sbjct: 601 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 660
Query: 661 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 720
WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES
Sbjct: 661 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 720
Query: 721 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 780
PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK
Sbjct: 721 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 780
Query: 781 PEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGES 840
PEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGES
Sbjct: 781 PEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGES 840
Query: 841 ETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET 900
ETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET
Sbjct: 841 ETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET 900
Query: 901 SGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSS 960
SGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSS
Sbjct: 901 SGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSS 960
Query: 961 TKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPT 1020
TKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPT
Sbjct: 961 TKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPT 1020
Query: 1021 NIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRF 1080
NIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRF
Sbjct: 1021 NIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRF 1080
Query: 1081 QQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYK 1140
QQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYK
Sbjct: 1081 QQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYK 1140
Query: 1141 VVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVI 1200
VVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVI
Sbjct: 1141 VVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVI 1200
Query: 1201 FGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTY 1260
FGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTY
Sbjct: 1201 FGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTY 1260
Query: 1261 GRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC 1320
GRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC
Sbjct: 1261 GRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC 1320
Query: 1321 ERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1352
ERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Sbjct: 1321 ERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1352
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sapiens]
Length = 1360
Score = 2699 bits (6997), Expect = 0.0
Identities = 1352/1360 (99%), Positives = 1352/1360 (99%), Gaps = 8/1360 (0%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
Query: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
Query: 421 REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480
REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL
Sbjct: 421 REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480
Query: 481 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 540
EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER
Sbjct: 481 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 540
Query: 541 SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 600
SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS
Sbjct: 541 SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 600
Query: 601 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 660
QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS
Sbjct: 601 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 660
Query: 661 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 720
WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES
Sbjct: 661 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 720
Query: 721 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 780
PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK
Sbjct: 721 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 780
Query: 781 PEESRDITRPSRPA--------DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE 832
PEESRDITRPSRPA DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE
Sbjct: 781 PEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE 840
Query: 833 EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE 892
EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE
Sbjct: 841 EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE 900
Query: 893 GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 952
GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG
Sbjct: 901 GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 960
Query: 953 TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI 1012
TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI
Sbjct: 961 TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI 1020
Query: 1013 SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY 1072
SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY
Sbjct: 1021 SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY 1080
Query: 1073 NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD 1132
NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD
Sbjct: 1081 NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD 1140
Query: 1133 LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE 1192
LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE
Sbjct: 1141 LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE 1200
Query: 1193 EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED 1252
EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED
Sbjct: 1201 EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED 1260
Query: 1253 EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR 1312
EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR
Sbjct: 1261 EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR 1320
Query: 1313 AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1352
AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Sbjct: 1321 AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1360
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 2638 bits (6837), Expect = 0.0
Identities = 1323/1352 (97%), Positives = 1323/1352 (97%), Gaps = 29/1352 (2%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
Query: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
Query: 421 REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480
REQRRHYEEQMRREEERRRAEHEQE YKRKQL
Sbjct: 421 REQRRHYEEQMRREEERRRAEHEQE-----------------------------YKRKQL 451
Query: 481 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 540
EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER
Sbjct: 452 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 511
Query: 541 SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 600
SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS
Sbjct: 512 SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 571
Query: 601 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 660
QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS
Sbjct: 572 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 631
Query: 661 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 720
WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES
Sbjct: 632 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 691
Query: 721 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 780
PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK
Sbjct: 692 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 751
Query: 781 PEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGES 840
PEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGES
Sbjct: 752 PEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGES 811
Query: 841 ETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET 900
ETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET
Sbjct: 812 ETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET 871
Query: 901 SGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSS 960
SGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSS
Sbjct: 872 SGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSS 931
Query: 961 TKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPT 1020
TKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPT
Sbjct: 932 TKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPT 991
Query: 1021 NIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRF 1080
NIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRF
Sbjct: 992 NIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRF 1051
Query: 1081 QQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYK 1140
QQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYK
Sbjct: 1052 QQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYK 1111
Query: 1141 VVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVI 1200
VVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVI
Sbjct: 1112 VVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVI 1171
Query: 1201 FGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTY 1260
FGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTY
Sbjct: 1172 FGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTY 1231
Query: 1261 GRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC 1320
GRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC
Sbjct: 1232 GRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC 1291
Query: 1321 ERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1352
ERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Sbjct: 1292 ERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1323
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 2630 bits (6818), Expect = 0.0
Identities = 1323/1360 (97%), Positives = 1323/1360 (97%), Gaps = 37/1360 (2%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
Query: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
Query: 421 REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480
REQRRHYEEQMRREEERRRAEHEQE YKRKQL
Sbjct: 421 REQRRHYEEQMRREEERRRAEHEQE-----------------------------YKRKQL 451
Query: 481 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 540
EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER
Sbjct: 452 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 511
Query: 541 SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 600
SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS
Sbjct: 512 SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 571
Query: 601 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 660
QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS
Sbjct: 572 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 631
Query: 661 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 720
WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES
Sbjct: 632 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 691
Query: 721 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 780
PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK
Sbjct: 692 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 751
Query: 781 PEESRDITRPSRPA--------DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE 832
PEESRDITRPSRPA DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE
Sbjct: 752 PEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE 811
Query: 833 EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE 892
EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE
Sbjct: 812 EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE 871
Query: 893 GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 952
GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG
Sbjct: 872 GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 931
Query: 953 TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI 1012
TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI
Sbjct: 932 TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI 991
Query: 1013 SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY 1072
SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY
Sbjct: 992 SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY 1051
Query: 1073 NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD 1132
NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD
Sbjct: 1052 NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD 1111
Query: 1133 LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE 1192
LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE
Sbjct: 1112 LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE 1171
Query: 1193 EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED 1252
EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED
Sbjct: 1172 EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED 1231
Query: 1253 EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR 1312
EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR
Sbjct: 1232 EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR 1291
Query: 1313 AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1352
AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Sbjct: 1292 AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1331
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 2560 bits (6634), Expect = 0.0
Identities = 1296/1360 (95%), Positives = 1297/1360 (95%), Gaps = 63/1360 (4%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
Query: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
Query: 421 REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480
REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL
Sbjct: 421 REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480
Query: 481 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 540
EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKE+
Sbjct: 481 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEI--- 537
Query: 541 SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 600
PH LVAVKS
Sbjct: 538 -----------PH-----------------------------------------LVAVKS 545
Query: 601 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 660
QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS
Sbjct: 546 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 605
Query: 661 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 720
WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES
Sbjct: 606 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 665
Query: 721 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 780
PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK
Sbjct: 666 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 725
Query: 781 PEESRDITRPSRPA--------DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE 832
PEESRDITRPSRPA DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE
Sbjct: 726 PEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE 785
Query: 833 EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE 892
EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE
Sbjct: 786 EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE 845
Query: 893 GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 952
GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG
Sbjct: 846 GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 905
Query: 953 TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI 1012
TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI
Sbjct: 906 TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI 965
Query: 1013 SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY 1072
SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY
Sbjct: 966 SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY 1025
Query: 1073 NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD 1132
NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD
Sbjct: 1026 NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD 1085
Query: 1133 LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE 1192
LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE
Sbjct: 1086 LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE 1145
Query: 1193 EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED 1252
EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED
Sbjct: 1146 EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED 1205
Query: 1253 EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR 1312
EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR
Sbjct: 1206 EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR 1265
Query: 1313 AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1352
AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Sbjct: 1266 AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1305
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 2548 bits (6604), Expect = 0.0
Identities = 1287/1352 (95%), Positives = 1291/1352 (95%), Gaps = 55/1352 (4%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
Query: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
Query: 421 REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480
REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL
Sbjct: 421 REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480
Query: 481 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 540
EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKE
Sbjct: 481 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKE----------------- 523
Query: 541 SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 600
G+ P+ P + +IPHLVAVKS
Sbjct: 524 ----------------------------------GMSPSEKPAWAK----EIPHLVAVKS 545
Query: 601 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 660
QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS
Sbjct: 546 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 605
Query: 661 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 720
WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES
Sbjct: 606 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 665
Query: 721 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 780
PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK
Sbjct: 666 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 725
Query: 781 PEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGES 840
PEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGES
Sbjct: 726 PEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGES 785
Query: 841 ETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET 900
ETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET
Sbjct: 786 ETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET 845
Query: 901 SGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSS 960
SGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSS
Sbjct: 846 SGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSS 905
Query: 961 TKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPT 1020
TKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPT
Sbjct: 906 TKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPT 965
Query: 1021 NIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRF 1080
NIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRF
Sbjct: 966 NIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRF 1025
Query: 1081 QQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYK 1140
QQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYK
Sbjct: 1026 QQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYK 1085
Query: 1141 VVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVI 1200
VVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVI
Sbjct: 1086 VVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVI 1145
Query: 1201 FGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTY 1260
FGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTY
Sbjct: 1146 FGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTY 1205
Query: 1261 GRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC 1320
GRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC
Sbjct: 1206 GRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC 1265
Query: 1321 ERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1352
ERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Sbjct: 1266 ERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1297
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 2479 bits (6425), Expect = 0.0
Identities = 1258/1352 (93%), Positives = 1262/1352 (93%), Gaps = 84/1352 (6%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
Query: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
Query: 421 REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480
REQRRHYEEQMRREEERRRAEHEQE YKRKQL
Sbjct: 421 REQRRHYEEQMRREEERRRAEHEQE-----------------------------YKRKQL 451
Query: 481 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 540
EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKE
Sbjct: 452 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKE----------------- 494
Query: 541 SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 600
G+ P+ P + +IPHLVAVKS
Sbjct: 495 ----------------------------------GMSPSEKPAWAK----EIPHLVAVKS 516
Query: 601 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 660
QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS
Sbjct: 517 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 576
Query: 661 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 720
WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES
Sbjct: 577 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 636
Query: 721 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 780
PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK
Sbjct: 637 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 696
Query: 781 PEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGES 840
PEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGES
Sbjct: 697 PEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGES 756
Query: 841 ETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET 900
ETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET
Sbjct: 757 ETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET 816
Query: 901 SGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSS 960
SGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSS
Sbjct: 817 SGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSS 876
Query: 961 TKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPT 1020
TKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPT
Sbjct: 877 TKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPT 936
Query: 1021 NIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRF 1080
NIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRF
Sbjct: 937 NIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRF 996
Query: 1081 QQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYK 1140
QQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYK
Sbjct: 997 QQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYK 1056
Query: 1141 VVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVI 1200
VVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVI
Sbjct: 1057 VVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVI 1116
Query: 1201 FGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTY 1260
FGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTY
Sbjct: 1117 FGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTY 1176
Query: 1261 GRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC 1320
GRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC
Sbjct: 1177 GRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC 1236
Query: 1321 ERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1352
ERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Sbjct: 1237 ERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1268
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 2476 bits (6416), Expect = 0.0
Identities = 1262/1360 (92%), Positives = 1265/1360 (93%), Gaps = 92/1360 (6%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
Query: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
Query: 421 REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480
REQRRHYEEQMRREEERRRAEHEQEY R+QL EEQRQ E LQ+Q
Sbjct: 421 REQRRHYEEQMRREEERRRAEHEQEYKRKQL-EEQRQAERLQRQ---------------- 463
Query: 481 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 540
LKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKE+
Sbjct: 464 ------------LKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEI--- 508
Query: 541 SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 600
PH LVAVKS
Sbjct: 509 -----------PH-----------------------------------------LVAVKS 516
Query: 601 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 660
QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS
Sbjct: 517 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 576
Query: 661 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 720
WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES
Sbjct: 577 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 636
Query: 721 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 780
PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK
Sbjct: 637 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 696
Query: 781 PEESRDITRPSRPA--------DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE 832
PEESRDITRPSRPA DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE
Sbjct: 697 PEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE 756
Query: 833 EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE 892
EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE
Sbjct: 757 EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE 816
Query: 893 GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 952
GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG
Sbjct: 817 GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 876
Query: 953 TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI 1012
TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI
Sbjct: 877 TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI 936
Query: 1013 SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY 1072
SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY
Sbjct: 937 SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY 996
Query: 1073 NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD 1132
NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD
Sbjct: 997 NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD 1056
Query: 1133 LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE 1192
LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE
Sbjct: 1057 LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE 1116
Query: 1193 EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED 1252
EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED
Sbjct: 1117 EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED 1176
Query: 1253 EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR 1312
EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR
Sbjct: 1177 EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR 1236
Query: 1313 AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1352
AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Sbjct: 1237 AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1276
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 1686 bits (4366), Expect = 0.0
Identities = 914/1392 (65%), Positives = 1039/1392 (74%), Gaps = 112/1392 (8%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
Query: 417 KQQEREQRRHYEEQMRR-----------------EEERRRAEHEQEYIRRQLEEEQRQLE 459
+QQEREQRR +E+ RR EEE+RR E EQEYIRRQLEEEQR LE
Sbjct: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
Query: 460 ILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRP------- 512
+LQQQLL EQA+LLE + +++EE RQAERLQRQL+QE+ YL+SLQH + P
Sbjct: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540
Query: 513 ----VEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRS 568
KP +H E + E A+EVE+R R SSP K R+ +P +P RS
Sbjct: 541 PPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRS 600
Query: 569 ESFSISGVQPARTPPMLRPVDPQI--PHLVAVKSQGPALTASQSVHEQPTKGLSGFQEAL 626
ESFS +G + P + RP +PQ+ HL ++K+ ++ S S + K +
Sbjct: 601 ESFS-NGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQ 659
Query: 627 N-VTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEED-IPPKVPQRTTSISPALA 684
+ R E+ Q+SD SE P PT + +W R + D +PP+VP RTTS SP L+
Sbjct: 660 DPCPPSRSEVLSQSSDSKSEAPD-PT------QKAWSRSDSDEVPPRVPVRTTSRSPVLS 712
Query: 685 RKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQG 744
R++SP GS Q S+ + R +E + R SGSSS SS SQP
Sbjct: 713 RRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP---- 768
Query: 745 GSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA---DLTALAK 801
GS PGSQ+GS ER RVR++SKSEGSP E A KPE+ +++ RP +PA DLTALAK
Sbjct: 769 GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAK 828
Query: 802 ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP 861
ELR + E RP KVTDYSSSSEES +++EE++D E E D + + + R +
Sbjct: 829 ELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNL 885
Query: 862 GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET-SGEKKRSGHSDSNGFAGHIN 920
+ E +V + H S + + S+EGTL++R+T S H S+ F I+
Sbjct: 886 SNGETESVKTMIVHDDVESEP---AMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFID 942
Query: 921 LPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTD 980
P L+Q S S T T +G
Sbjct: 943 -PRLLQISPSSGTTVTSVVG---------------------------------------- 961
Query: 981 EDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNS 1040
F+ + +R E + + RK SVVNVNPTN RP SDTPEIRKYKKRFNS
Sbjct: 962 -------------FSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNS 1008
Query: 1041 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKN 1100
EILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLEGLNVLVTISGKK+
Sbjct: 1009 EILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKD 1068
Query: 1101 KLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEI 1160
KLRVYYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERIKFLVIALK++VE+
Sbjct: 1069 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEV 1128
Query: 1161 YAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDI 1220
YAWAPKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS GFH +DVDSG+ YDI
Sbjct: 1129 YAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDI 1188
Query: 1221 YIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAY 1280
Y+P+HIQ +I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAY
Sbjct: 1189 YLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAY 1248
Query: 1281 IHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVF 1340
I SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+
Sbjct: 1249 IRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1308
Query: 1341 FMTLNRNSMMNW 1352
FMTL R S+++W
Sbjct: 1309 FMTLGRTSLLSW 1320
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 1655 bits (4287), Expect = 0.0
Identities = 899/1391 (64%), Positives = 1036/1391 (74%), Gaps = 135/1391 (9%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
Query: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
Query: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEY 475
QE+EQ+R E+ +RREEERR+AE EQE Y
Sbjct: 421 LQEKEQQRRLEDMQALRREEERRQAEREQE-----------------------------Y 451
Query: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQR----------PVEKKPLYHYKEGM 525
KRKQLEEQRQ+ERLQRQL+QE YL SLQ Q+Q+Q+ P ++KPLYHY GM
Sbjct: 452 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM 511
Query: 526 SPSEKPAWAKEVEERSRLNRQ-SSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPM 584
+P++KPAWA+EVEER+R+N+Q +SP K + +P +P S ++TPPM
Sbjct: 512 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPG---PPGPLSQTPPM 568
Query: 585 LRPVDPQ-------IPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALN---------- 627
RPV+PQ + H V +K + SQS+ +QPT+ L+ F + +
Sbjct: 569 QRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTA 628
Query: 628 VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARK 686
S R + RQNSDPTSE P P P + +W+R + + PPKVPQRT+SI+ AL
Sbjct: 629 TPSARGAVIRQNSDPTSEGPGPSP------NPPAWVRPDNEAPPKVPQRTSSIATAL--- 679
Query: 687 NSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGS 746
N S G +Q +RASNPDLRR++P E S S P+S G
Sbjct: 680 ----NTSGAGGSRPAQAVRASNPDLRRSDPGWER----------SDSVLPASH-----GH 720
Query: 747 QPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELREL 806
P QAGS ER RV +SK + SPVL K KP++ R +RP RPAD L +E
Sbjct: 721 LP--QAGSLERNRVGVSSKPDSSPVLS-PGNKAKPDDHR--SRPGRPADFVLL----KER 771
Query: 807 RIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQ 866
++E RP KK DYSSSSEE ESSE++EE+GE +G+ D P G +
Sbjct: 772 TLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGS---RDTP-----GGRSDGDT 823
Query: 867 YNVGMVGTHGLE--TSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDL 924
+V + H +E T + G GT++++ T E++ H+DSNG+ NLPD+
Sbjct: 824 DSVSTMVVHDVEEITGTQPPYGG-----GTMVVQRTPEEERNLLHADSNGYT---NLPDV 875
Query: 925 VQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMG---SSTKASFTPFVDPRVYQTSPTDE 981
VQ SHSP TE S S++ SG G + K+SFT FVD +YQ + +
Sbjct: 876 VQPSHSP----TENSKGQSPPSKD-GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGD 930
Query: 982 DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE 1041
AL E R +Q + + RK SVVNVNPTN R HS+TPEIRKYKKRFNSE
Sbjct: 931 S-----IPITALVGGEGTRLDQLQY-DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSE 984
Query: 1042 ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK 1101
ILCAALWGVNLLVGTENGLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK+NK
Sbjct: 985 ILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNK 1044
Query: 1102 LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY 1161
LRVYYLSWLRN+ILHNDPEVEKKQGW TVGD+EGC HY+VVKYERIKFLVIALK++VE+Y
Sbjct: 1045 LRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVY 1104
Query: 1162 AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY 1221
AWAPKPYHKFMAFKSFADL H+PLLVDLTVEEGQRLKVI+GS GFH +DVDSGNSYDIY
Sbjct: 1105 AWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIY 1164
Query: 1222 IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI 1281
IP HIQ ITPHAI+ LP TDGMEML+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI
Sbjct: 1165 IPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYI 1224
Query: 1282 HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF 1341
SNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+F
Sbjct: 1225 CSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYF 1284
Query: 1342 MTLNRNSMMNW 1352
MTLNRN +MNW
Sbjct: 1285 MTLNRNCIMNW 1295
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 1653 bits (4280), Expect = 0.0
Identities = 899/1395 (64%), Positives = 1036/1395 (74%), Gaps = 135/1395 (9%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
Query: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
Query: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEY 475
QE+EQ+R E+ +RREEERR+AE EQE Y
Sbjct: 421 LQEKEQQRRLEDMQALRREEERRQAEREQE-----------------------------Y 451
Query: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQR----------PVEKKPLYHYKEGM 525
KRKQLEEQRQ+ERLQRQL+QE YL SLQ Q+Q+Q+ P ++KPLYHY GM
Sbjct: 452 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM 511
Query: 526 SPSEKPAWAKEVEERSRLNRQ-SSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPM 584
+P++KPAWA+EVEER+R+N+Q +SP K + +P +P S ++TPPM
Sbjct: 512 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPG---PPGPLSQTPPM 568
Query: 585 LRPVDPQ-------IPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALN---------- 627
RPV+PQ + H V +K + SQS+ +QPT+ L+ F + +
Sbjct: 569 QRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTA 628
Query: 628 VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARK 686
S R + RQNSDPTSE P P P + +W+R + + PPKVPQRT+SI+ AL
Sbjct: 629 TPSARGAVIRQNSDPTSEGPGPSP------NPPAWVRPDNEAPPKVPQRTSSIATAL--- 679
Query: 687 NSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGS 746
N S G +Q +RASNPDLRR++P E S S P+S G
Sbjct: 680 ----NTSGAGGSRPAQAVRASNPDLRRSDPGWER----------SDSVLPASH-----GH 720
Query: 747 QPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKE---- 802
P QAGS ER RV +SK + SPVL K KP++ R +RP RPA E
Sbjct: 721 LP--QAGSLERNRVGVSSKPDSSPVLS-PGNKAKPDDHR--SRPGRPASYKRAIGEDFVL 775
Query: 803 LRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPG 862
L+E ++E RP KK DYSSSSEE ESSE++EE+GE +G+ D P G
Sbjct: 776 LKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGS---RDTP-----GGRS 827
Query: 863 SNEQYNVGMVGTHGLE--TSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHIN 920
+ +V + H +E T + G GT++++ T E++ H+DSNG+ N
Sbjct: 828 DGDTDSVSTMVVHDVEEITGTQPPYGG-----GTMVVQRTPEEERNLLHADSNGYT---N 879
Query: 921 LPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMG---SSTKASFTPFVDPRVYQTS 977
LPD+VQ SHSP TE S S++ SG G + K+SFT FVD +YQ
Sbjct: 880 LPDVVQPSHSP----TENSKGQSPPSKD-GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPG 934
Query: 978 PTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKR 1037
+ + AL E R +Q + + RK SVVNVNPTN R HS+TPEIRKYKKR
Sbjct: 935 GSGDS-----IPITALVGGEGTRLDQLQY-DVRKGSVVNVNPTNTRAHSETPEIRKYKKR 988
Query: 1038 FNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISG 1097
FNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISG
Sbjct: 989 FNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISG 1048
Query: 1098 KKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNA 1157
K+NKLRVYYLSWLRN+ILHNDPEVEKKQGW TVGD+EGC HY+VVKYERIKFLVIALK++
Sbjct: 1049 KRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSS 1108
Query: 1158 VEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNS 1217
VE+YAWAPKPYHKFMAFKSFADL H+PLLVDLTVEEGQRLKVI+GS GFH +DVDSGNS
Sbjct: 1109 VEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNS 1168
Query: 1218 YDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTS 1277
YDIYIP HIQ ITPHAI+ LP TDGMEML+CYEDEGVYVNTYGRI KDVVLQWGEMPTS
Sbjct: 1169 YDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTS 1228
Query: 1278 VAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSS 1337
VAYI SNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSS
Sbjct: 1229 VAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSS 1288
Query: 1338 QVFFMTLNRNSMMNW 1352
QV+FMTLNRN +MNW
Sbjct: 1289 QVYFMTLNRNCIMNW 1303
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 1641 bits (4249), Expect = 0.0
Identities = 899/1421 (63%), Positives = 1037/1421 (72%), Gaps = 158/1421 (11%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
Query: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
Query: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEY 475
QE+EQ+R E+ +RREEERR+AE EQE Y
Sbjct: 421 LQEKEQQRRLEDMQALRREEERRQAEREQE-----------------------------Y 451
Query: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQR----------PVEKKPLYHYKEGM 525
KRKQLEEQRQ+ERLQRQL+QE YL SLQ Q+Q+Q+ P ++KPLYHY GM
Sbjct: 452 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM 511
Query: 526 SPSEKPAWAKEVEERSRLNRQ-SSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPM 584
+P++KPAWA+EVEER+R+N+Q +SP K + +P +P S ++TPPM
Sbjct: 512 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPG---PPGPLSQTPPM 568
Query: 585 LRPVDPQ-------IPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALN---------- 627
RPV+PQ + H V +K + SQS+ +QPT+ L+ F + +
Sbjct: 569 QRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTA 628
Query: 628 VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARK 686
S R + RQNSDPTSE P P P + +W+R + + PPKVPQRT+SI+ AL
Sbjct: 629 TPSARGAVIRQNSDPTSEGPGPSP------NPPAWVRPDNEAPPKVPQRTSSIATALNTS 682
Query: 687 NSPGNGSALG----PRLGSQ--------------------------PIRASNPDLRRTEP 716
+ G+ A PR S P +SNPDLRR++P
Sbjct: 683 GAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDP 742
Query: 717 ILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEP 776
E S S P+S G P QAGS ER RV +SK + SPVL
Sbjct: 743 GWER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDSSPVLS-PG 784
Query: 777 AKVKPEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEE 836
K KP++ R +RP RPAD L +E ++E RP KK DYSSSSEE ESSE++EE
Sbjct: 785 NKAKPDDHR--SRPGRPADFVLL----KERTLDEAPRPPKKAMDYSSSSEEVESSEDDEE 838
Query: 837 DGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSFSGSISREGT 894
+GE +G+ D P G + +V + H +E T + G GT
Sbjct: 839 EGEGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPYGG-----GT 885
Query: 895 LMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTE 954
++++ T E++ H+DSNG+ NLPD+VQ SHSP TE S S++ SG
Sbjct: 886 MVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPPSKD-GSGDY 937
Query: 955 YGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARK 1011
G + K+SFT FVD +YQ + + AL E R +Q + + RK
Sbjct: 938 QSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLDQLQY-DVRK 991
Query: 1012 ISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV 1071
SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV
Sbjct: 992 GSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV 1051
Query: 1072 YNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVG 1131
Y LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVEKKQGW TVG
Sbjct: 1052 YGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVG 1111
Query: 1132 DLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTV 1191
D+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H+PLLVDLTV
Sbjct: 1112 DMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTV 1171
Query: 1192 EEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYE 1251
EEGQRLKVI+GS GFH +DVDSGNSYDIYIP HIQ ITPHAI+ LP TDGMEML+CYE
Sbjct: 1172 EEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYE 1231
Query: 1252 DEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHK 1311
DEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETGHLDGVFMHK
Sbjct: 1232 DEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHK 1291
Query: 1312 RAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1352
RAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1292 RAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1332
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 1632 bits (4226), Expect = 0.0
Identities = 896/1414 (63%), Positives = 1033/1414 (73%), Gaps = 164/1414 (11%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
Query: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
Query: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEY 475
QE+EQ+R E+ +RREEERR+AE EQE Y
Sbjct: 421 LQEKEQQRRLEDMQALRREEERRQAEREQE-----------------------------Y 451
Query: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQR----------PVEKKPLYHYKEGM 525
KRKQLEEQRQ+ERLQRQL+QE YL SLQ Q+Q+Q+ P ++KPLYHY GM
Sbjct: 452 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM 511
Query: 526 SPSEKPAWAKEVEERSRLNRQ-SSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPM 584
+P++KPAWA+EVEER+R+N+Q +SP K + +P +P S ++TPPM
Sbjct: 512 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPG---PPGPLSQTPPM 568
Query: 585 LRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALN----------VTSHRVE 634
RPV+PQ +GP +S+ +QPT+ L+ F + + S R
Sbjct: 569 QRPVEPQ---------EGP----HKSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGA 615
Query: 635 MPRQNSDPTSENP-PLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGS 693
+ RQNSDPTSE P P P + +W+R + + PPKVPQRT+SI+ AL + G+
Sbjct: 616 VIRQNSDPTSEGPGPSP------NPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRP 669
Query: 694 ALG----PRLGSQ--------------------------PIRASNPDLRRTEPILESPLQ 723
A PR S P +SNPDLRR++P E
Sbjct: 670 AQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWER--- 726
Query: 724 RTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEE 783
S S P+S G P QAGS ER RV +SK + SPVL K KP++
Sbjct: 727 -------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDSSPVLS-PGNKAKPDD 771
Query: 784 SRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETH 843
R +RP RPAD L +E ++E RP KK DYSSSSEE ESSE++EE+GE
Sbjct: 772 HR--SRPGRPADFVLL----KERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPA 825
Query: 844 DGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSFSGSISREGTLMIRETS 901
+G+ D P G + +V + H +E T + G GT++++ T
Sbjct: 826 EGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPYGG-----GTMVVQRTP 872
Query: 902 GEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMG--- 958
E++ H+DSNG+ NLPD+VQ SHSP TE S S++ SG G
Sbjct: 873 EEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPPSKD-GSGDYQSRGLVK 924
Query: 959 SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVN 1018
+ K+SFT FVD +YQ + + AL E R +Q + + RK SVVNVN
Sbjct: 925 APGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLDQLQY-DVRKGSVVNVN 978
Query: 1019 PTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRR 1078
PTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY LI RR
Sbjct: 979 PTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRR 1038
Query: 1079 RFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIH 1138
RFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVEKKQGW TVGD+EGC H
Sbjct: 1039 RFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGH 1098
Query: 1139 YKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLK 1198
Y+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H+PLLVDLTVEEGQRLK
Sbjct: 1099 YRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLK 1158
Query: 1199 VIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVN 1258
VI+GS GFH +DVDSGNSYDIYIP HIQ ITPHAI+ LP TDGMEML+CYEDEGVYVN
Sbjct: 1159 VIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVN 1218
Query: 1259 TYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKF 1318
TYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKF
Sbjct: 1219 TYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKF 1278
Query: 1319 LCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1352
LCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1279 LCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1312
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 1586 bits (4107), Expect = 0.0
Identities = 878/1379 (63%), Positives = 989/1379 (71%), Gaps = 194/1379 (14%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
Query: 417 KQQEREQRRHYEEQMRR-----------------EEERRRAEHEQEYIRRQLEEEQRQLE 459
+QQEREQRR +E+ RR EEE+RR E EQEYIRRQLEEEQR LE
Sbjct: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
Query: 460 ILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEK--KP 517
+LQQQLL EQA+LL R+ QH +Q P ++ KP
Sbjct: 481 VLQQQLLQEQAMLLHDHRRP----------------------HPQHSQQPPPPQQERSKP 518
Query: 518 LYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQ 577
+H E + E A+EVE+R R SSP K R+ +P +P RSESFS +G
Sbjct: 519 SFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFS-NGNS 577
Query: 578 PARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPR 637
+ P + RP +PQ+P V S+ P L S + P +G SG Q + + +
Sbjct: 578 ESVHPALQRPAEPQVP--VRTTSRSPVL----SRRDSPLQG-SGQQNS--------QAGQ 622
Query: 638 QNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGP 697
+NS + E R W R E+ +P PG+GS
Sbjct: 623 RNSTSSIE-----------PRLLWERVEKLVP------------------RPGSGS---- 649
Query: 698 RLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSER 757
SSGSS+S S P GS PGSQ+GS ER
Sbjct: 650 ----------------------------SSGSSNSGSQP--------GSHPGSQSGSGER 673
Query: 758 TRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA---DLTALAKELRELRIEETNRP 814
RVR++SKSEGSP E A KPE+ +++ RP +PA DLTALAKELR + E RP
Sbjct: 674 FRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAV---EDVRP 730
Query: 815 MKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGT 874
KVTDYSSSSEES +++EE++D E E D + + + R + + E +V +
Sbjct: 731 PHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIV 790
Query: 875 HGLETSHADSFSGSISREGTLMIRET-SGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAG 933
H S + + S+EGTL++R+T S H S+ F I+ P L+Q S S
Sbjct: 791 HDDVESEP---AMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFID-PRLLQISPSSGT 846
Query: 934 TPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAAL 993
T T +G
Sbjct: 847 TVTSVVG----------------------------------------------------- 853
Query: 994 FTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLL 1053
F+ + +R E + + RK SVVNVNPTN RP SDTPEIRKYKKRFNSEILCAALWGVNLL
Sbjct: 854 FSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLL 913
Query: 1054 VGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNR 1113
VGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLEGLNVLVTISGKK+KLRVYYLSWLRN+
Sbjct: 914 VGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNK 973
Query: 1114 ILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMA 1173
ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERIKFLVIALK++VE+YAWAPKPYHKFMA
Sbjct: 974 ILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMA 1033
Query: 1174 FKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPH 1233
FKSF +L HKPLLVDLTVEEGQRLKVI+GS GFH +DVDSG+ YDIY+P+HIQ +I PH
Sbjct: 1034 FKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKPH 1093
Query: 1234 AIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKA 1293
AI+ILP TDGME+LVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI SNQ MGWGEKA
Sbjct: 1094 AIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKA 1153
Query: 1294 IEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1352
IEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTL R S+++W
Sbjct: 1154 IEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW 1212
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 842 bits (2175), Expect = 0.0
Identities = 481/830 (57%), Positives = 557/830 (67%), Gaps = 77/830 (9%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
Query: 417 KQQEREQRRHYEEQMRR-----------------EEERRRAEHEQEYIRRQLEEEQRQLE 459
+QQEREQRR +E+ RR EEE+RR E EQEYIRRQLEEEQR LE
Sbjct: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
Query: 460 ILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEK--KP 517
+LQQQLL EQA+LL R+ QH +Q P ++ KP
Sbjct: 481 VLQQQLLQEQAMLLHDHRRP----------------------HPQHSQQPPPPQQERSKP 518
Query: 518 LYHYKEGMSPSEKPAWAKEVEERSR-----LNRQSSPAMPHKVANRISDPNLPPRSESFS 572
+H E + E A+EV R+ L+R+ SP N + S
Sbjct: 519 SFHAPEPKAHYEPADRAREVPVRTTSRSPVLSRRDSPLQGSGQQN-------SQAGQRNS 571
Query: 573 ISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHR 632
S ++P + V+ +P + S G + + SQ ++ SG + + +S
Sbjct: 572 TSSIEPRL---LWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKS 628
Query: 633 VEMPRQNSDPTSENP--------PLPT--RIEKFDRSSWLRQEEDIPPKVPQRTTSISPA 682
P Q + + P PL ++ + LR ED+ P P + T S +
Sbjct: 629 EGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRP--PHKVTDYSSS 686
Query: 683 LARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPIL----ESPLQRTSSGSSSSSSTPSS 738
+ + G+ + D R + E+ +T S P+
Sbjct: 687 SEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAM 746
Query: 739 QPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDIT 788
PS + G+ Q S+ T + S S +P + ++ P +T
Sbjct: 747 TPSKE-GTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVT 795
Score = 792 bits (2045), Expect = 0.0
Identities = 486/993 (48%), Positives = 600/993 (60%), Gaps = 153/993 (15%)
Query: 396 EEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQE---------- 445
++ E++ R++ + ++ +K+ E+++ YE EEE E E E
Sbjct: 291 DQPNERQVRIQLKDHIDRTRKKRGEKDETE-YEYSGSEEEEEEVPEQEGEPSSIVNVPGE 349
Query: 446 ------YIRRQLEEEQRQLEILQQQLLHEQALLL--EYKRKQLEEQRQAERLQRQLKQER 497
++R Q E ++R + +QQLL EQ L EYKR+ L E+ Q++++Q++
Sbjct: 350 STLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAER------QKRIEQQK 403
Query: 498 DYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVAN 557
+ L+ Q++ +R ++ E+ +E EE+ RL +
Sbjct: 404 EQRRRLEEQQRREREARRQ-----------QEREQRRREQEEKRRLEELERRRKEEEERR 452
Query: 558 RISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSV----HE 613
R + E I R ++ + HL ++ Q L Q++ H
Sbjct: 453 RAEEEKRRVEREQEYIR-----------RQLEEEQRHLEVLQQQ---LLQEQAMLLHDHR 498
Query: 614 QPTKGLSGFQEALNVTSHRVEMP---RQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPP 670
+P H + P ++ S P+ P E DR+
Sbjct: 499 RPHP------------QHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAR---------- 536
Query: 671 KVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSS 730
+VP RTTS SP L+R++SP GS Q S+ + R +E + R SGSS
Sbjct: 537 EVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSS 596
Query: 731 SSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRP 790
S SS SQP GS PGSQ+GS ER RVR++SKSEGSP E A KPE+ +++ RP
Sbjct: 597 SGSSNSGSQP----GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRP 652
Query: 791 SRPA---DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTV 847
+PA DLTALAKELR + E RP KVTDYSSSSEES +++EE++D E E
Sbjct: 653 LKPAGEVDLTALAKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQE------ 703
Query: 848 AVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRS 907
G++E T G E + A S L ET K
Sbjct: 704 --------------GADES-------TSGPEDTRAASSLN-------LSNGETESVKTMI 735
Query: 908 GHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTP 967
H D PA TP++ + +Q S + SS SFTP
Sbjct: 736 VHDDVES---------------EPAMTPSKEGTLIVRQTQSASSTLQKHKSSS---SFTP 777
Query: 968 FVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSD 1027
F+DPR+ Q SP+ ++ F+ + +R E + + RK SVVNVNPTN RP SD
Sbjct: 778 FIDPRLLQISPSS----GTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSD 833
Query: 1028 TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLE 1087
TPEIRKYKKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLE
Sbjct: 834 TPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLE 893
Query: 1088 GLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERI 1147
GLNVLVTISGKK+KLRVYYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERI
Sbjct: 894 GLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERI 953
Query: 1148 KFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGF 1207
KFLVIALK++VE+YAWAPKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS GF
Sbjct: 954 KFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGF 1013
Query: 1208 HVIDVDSGNSYDIYIPSHIQGN--------ITPHAIVILPKTDGMEMLVCYEDEGVYVNT 1259
H +DVDSG+ YDIY+P+H++ N I PHAI+ILP TDGME+LVCYEDEGVYVNT
Sbjct: 1014 HAVDVDSGSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNT 1073
Query: 1260 YGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFL 1319
YGRITKDVVLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFL
Sbjct: 1074 YGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFL 1133
Query: 1320 CERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1352
CERNDKVFFASVRSGGSSQV+FMTL R S+++W
Sbjct: 1134 CERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW 1166
>gi|118600963 Nik related kinase [Homo sapiens]
Length = 1582
Score = 412 bits (1059), Expect = e-114
Identities = 268/729 (36%), Positives = 392/729 (53%), Gaps = 68/729 (9%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT- 59
MA R + DL L DP GIF L + +G GTYG++Y G H KTG A+KVM+
Sbjct: 1 MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK 60
Query: 60 -----------------------GDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPG 96
DEEE+++ E+N+L+KYS H+NI ++YGAF K +PPG
Sbjct: 61 TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG 120
Query: 97 MDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKG 156
QLW+VME C AGSVTD+++ T +LKE+WIAYICREIL+GL+HLH H+VIHRDIKG
Sbjct: 121 QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG 180
Query: 157 QNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDL 216
QNVLLT NAEVKLVDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P +YD++SD+
Sbjct: 181 QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV 240
Query: 217 WSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQ 276
WS+GITAIEMAEGAPPLC++ P+ ALF+I R AP +KS WS+KF +F+E C +KN
Sbjct: 241 WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF 300
Query: 277 RPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDET---EYEYSGSEEEEEEN 333
RP + +++HPF+RD NER V L H+ KKR +K E E + E+
Sbjct: 301 RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR 360
Query: 334 DSGEPS---SILNLPGESTLRRDFLRL---------QLANKERSEALRRQQLEQQQRENE 381
G PS +L LP S R LR+ L ++E + QQL+ R
Sbjct: 361 FRG-PSCTHELLRLPTSSRCRP--LRVLHGEPSQPRWLPDREEPQVQALQQLQGAAR--V 415
Query: 382 EHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAE 441
Q L K ++ Q + +RL+ R L+ Q + + + + Q++ RRA
Sbjct: 416 FMPLQALDSAPKPLKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAA 475
Query: 442 HEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQL-KQERDYL 500
++ Q+ R L++ Q +QA + + L++ + + Q Q+ +Q+R
Sbjct: 476 RVLMPLQAQV-RAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQGQ 534
Query: 501 VSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRIS 560
Q QR Q P ++ ++ +P E+P ++ E ++ ++ +V ++
Sbjct: 535 APEQQQRHNQVPEQE-----LEQNQAP-EQPEVQEQAAEPAQAETEAEEPESLRVNAQVF 588
Query: 561 DPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLS 620
P L ++ +L P+ L+ V+ Q +Q+ +P + +
Sbjct: 589 LPLL--------------SQDHHVLLPLHLDTQVLIPVEGQTEGSPQAQAWTLEPPQAIG 634
Query: 621 GFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSIS 680
Q + S R + NS+ + PL T +E + + Q E K + +++
Sbjct: 635 SVQALIEGLS-RDLLRAPNSNNSKPLGPLQTLMENLSSNRFYSQPEQAREK-KSKVSTLR 692
Query: 681 PALARKNSP 689
ALA++ SP
Sbjct: 693 QALAKRLSP 701
Score = 274 bits (701), Expect = 4e-73
Identities = 152/416 (36%), Positives = 233/416 (56%), Gaps = 58/416 (13%)
Query: 989 SAAALFTSELLRQEQAKLNEA--RKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAA 1046
SA A F S +L ++ E ++ S VNVNP + P P I Y+K F SEI C +
Sbjct: 1157 SADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPLIHMYEKEFTSEICCGS 1216
Query: 1047 LWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYY 1106
LWGVNLL+GT + L L+DRSG+ + LI RR F+Q+ VLE LN+L+TISG KN+LRVY+
Sbjct: 1217 LWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVYH 1276
Query: 1107 LSWLRNRILHNDPEVEKKQGWI--------TVGDLEGCIHYKVVKYERIKFLVIALKNAV 1158
L+WLRN+IL+NDPE +++Q + + L GC H+ V+++E ++ IALK+++
Sbjct: 1277 LTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAIALKSSI 1336
Query: 1159 EIYAWAPK---------------------------------------PYHKF-------- 1171
+YAWAPK P ++F
Sbjct: 1337 HLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKRPDELLH 1396
Query: 1172 -MAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNI 1230
+ K F L HKP+ VDL + +RLK+ F S G+H+ID +S D+ +P + I
Sbjct: 1397 LLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPKNPLEII 1456
Query: 1231 TPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWG 1290
P I+ILP G+ M++ + E + V ++ K ++ W ++P+S+A+ + + GWG
Sbjct: 1457 IPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRTTGWG 1516
Query: 1291 EKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNR 1346
+KAIE+RS+++ L+ + ++L+FLC R DK+FF S S+V+FMTL +
Sbjct: 1517 QKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGK 1572
Score = 33.9 bits (76), Expect = 1.1
Identities = 28/108 (25%), Positives = 47/108 (43%), Gaps = 12/108 (11%)
Query: 350 LRRDFLRLQLANKERS--------EALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQ 401
L RD LR +N + E L + Q + E K ++ RQ + +
Sbjct: 643 LSRDLLRAPNSNNSKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLSPK 702
Query: 402 RRRLEEQQRREK----ELRKQQEREQRRHYEEQMRREEERRRAEHEQE 445
R R + R EK +L +++R QRR + + EEE R+ + ++E
Sbjct: 703 RFRAKSSWRPEKLELSDLEARRQRRQRRWEDIFNQHEEELRQVDKDKE 750
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 306 bits (785), Expect = 7e-83
Identities = 155/311 (49%), Positives = 207/311 (66%), Gaps = 11/311 (3%)
Query: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHH 79
DP+ +E+ E +G GTYG+V+K + K GQ AA+K++D D +EEI+ E N+LK S H
Sbjct: 16 DPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEAEYNILKALSDH 75
Query: 80 RNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKN--TKGNTLKEEWIAYICREI 137
N+ +YG + KK+ D+LWLV+E C GSVTDL+K +G + E IAYI E
Sbjct: 76 PNVVRFYGIYFKKDKVN-GDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEA 134
Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L GL HLH +K IHRD+KG N+LLT VKLVDFGVSAQL T RRNT +GTP+WMAP
Sbjct: 135 LMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAP 194
Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
EVIAC++ D TYD + D WSLGITAIE+ +G PPL D+HPMRALF IPRNP P+L+ +
Sbjct: 195 EVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPE 254
Query: 258 -WSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-----RDQPNERQVR--IQLKDHIDRT 309
WS +F FI CL K++ +RP +L++H FI +D ++Q+ I + + T
Sbjct: 255 LWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGKDVMLQKQLTEFIGIHQCMGGT 314
Query: 310 KKKRGEKDETE 320
+K R E+ T+
Sbjct: 315 EKARRERIHTK 325
>gi|134288915 myosin IIIB isoform 1 [Homo sapiens]
Length = 1314
Score = 296 bits (758), Expect = 9e-80
Identities = 152/328 (46%), Positives = 211/328 (64%), Gaps = 11/328 (3%)
Query: 13 IDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINM 72
+ L +L DP +E++E +G GTYG+VYK + + G LAA+K++D D +EEI+ E N+
Sbjct: 15 LGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNI 74
Query: 73 LKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTK--GNTLKEEWI 130
L+ +H N+ +YG F K + + QLWLV+E C GSVT+L+K G L E I
Sbjct: 75 LQFLPNHPNVVKFYGMFYKADHC-VGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMI 133
Query: 131 AYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIG 190
+YI L GL HLH +++IHRD+KG N+LLT VKLVDFGVSAQL T RRNT +G
Sbjct: 134 SYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVG 193
Query: 191 TPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPA 250
TP+WMAPEVIAC++ D++YD + D+WSLGITAIE+ +G PPL DMHP++ LF IPRNP
Sbjct: 194 TPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPP 253
Query: 251 PR-LKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPN-----ERQVRIQLKD 304
P L +KW ++F FI CL+K+ +RP+ L+ HPFI+ ++Q+ L+D
Sbjct: 254 PTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQD 313
Query: 305 --HIDRTKKKRGEKDETEYEYSGSEEEE 330
H + K R E+ T Y + E+
Sbjct: 314 QKHQNPVAKTRHERMHTRRPYHVEDAEK 341
>gi|134288892 myosin IIIB isoform 2 [Homo sapiens]
Length = 1341
Score = 296 bits (758), Expect = 9e-80
Identities = 152/328 (46%), Positives = 211/328 (64%), Gaps = 11/328 (3%)
Query: 13 IDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINM 72
+ L +L DP +E++E +G GTYG+VYK + + G LAA+K++D D +EEI+ E N+
Sbjct: 15 LGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNI 74
Query: 73 LKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTK--GNTLKEEWI 130
L+ +H N+ +YG F K + + QLWLV+E C GSVT+L+K G L E I
Sbjct: 75 LQFLPNHPNVVKFYGMFYKADHC-VGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMI 133
Query: 131 AYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIG 190
+YI L GL HLH +++IHRD+KG N+LLT VKLVDFGVSAQL T RRNT +G
Sbjct: 134 SYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVG 193
Query: 191 TPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPA 250
TP+WMAPEVIAC++ D++YD + D+WSLGITAIE+ +G PPL DMHP++ LF IPRNP
Sbjct: 194 TPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPP 253
Query: 251 PR-LKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPN-----ERQVRIQLKD 304
P L +KW ++F FI CL+K+ +RP+ L+ HPFI+ ++Q+ L+D
Sbjct: 254 PTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQD 313
Query: 305 --HIDRTKKKRGEKDETEYEYSGSEEEE 330
H + K R E+ T Y + E+
Sbjct: 314 QKHQNPVAKTRHERMHTRRPYHVEDAEK 341
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 273 bits (698), Expect = 8e-73
Identities = 164/417 (39%), Positives = 236/417 (56%), Gaps = 25/417 (5%)
Query: 6 PARSLDEIDLSAL-RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEE 64
P R L ++D +L + P +F+++E +G G+YG VYK H +TGQ+ AIK + V D +E
Sbjct: 10 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69
Query: 65 EIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNT 124
IK+ M + S H + YYG++ K LW+VME+CGAGSV+D+I+ + T
Sbjct: 70 IIKEISIMQQCDSPH--VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120
Query: 125 LKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
L E+ IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T+ +
Sbjct: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
Query: 185 RNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFL 244
RNT IGTP+WMAPEVI + Y+ +D+WSLGITAIEMAEG PP D+HPMRA+F+
Sbjct: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
Query: 245 IPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLK 303
IP NP P K + WS F F++ CLVK+ QR QL++HPF+R +R +
Sbjct: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLIN 295
Query: 304 DHIDRTKKKRGEKDETEYEYSGSE-EEEEENDSGEPSSILNLPGE--STLRRDFLRLQLA 360
+ +D K KR E + E + E EE+E DSG +++ G+ T+R A
Sbjct: 296 EAMD-VKLKRQESQQREVDQDDEENSEEDEMDSG---TMVRAVGDEMGTVRVASTMTDGA 351
Query: 361 NK--ERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKEL 415
N E + L Q +E + + R + ++ K EQ+ +E ++
Sbjct: 352 NTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQI 408
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 266 bits (679), Expect = 1e-70
Identities = 141/297 (47%), Positives = 197/297 (66%), Gaps = 15/297 (5%)
Query: 14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINML 73
DLS R+P FEL++ +G+GTYG VYK R+V TG+LAAIKV+ + E+ + Q+ ++
Sbjct: 6 DLSR-RNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIM 64
Query: 74 KKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYI 133
K H NI Y+G+++++ D+LW+ MEFCG GS+ D+ T L E IAY+
Sbjct: 65 MKDCKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYV 116
Query: 134 CREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
RE L+GL +LH +HRDIKG N+LLT+N VKL DFGVSAQ+ T+ +R +FIGTPY
Sbjct: 117 SRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPY 176
Query: 194 WMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAP 251
WMAPEV A + Y+ DLW++GITAIE+AE PP+ D+HPMRALFL+ ++ P
Sbjct: 177 WMAPEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPP 234
Query: 252 RLKSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHID 307
+LK K KWS F F++ L KN +RP E+L++HPF+ Q R + I+L D ++
Sbjct: 235 KLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV-TQHLTRSLAIELLDKVN 290
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 263 bits (672), Expect = 8e-70
Identities = 149/369 (40%), Positives = 224/369 (60%), Gaps = 38/369 (10%)
Query: 19 RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKYS 77
R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + GD+ I+QEI M+K+
Sbjct: 14 RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73
Query: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T L E IAY+CRE
Sbjct: 74 HC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRET 124
Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL++LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+ +R +FIGTPYWMAP
Sbjct: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 255
EV A ++N Y+ D+W++GITAIE+ E PP+ D+HPMRALFL+ ++ P+LK
Sbjct: 185 EVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242
Query: 256 K-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314
K KWS F +F++ L KN +RP E+L+ H F+ R + ++L D ++
Sbjct: 243 KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN------- 295
Query: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRR----------DFLRLQLANKER 364
+ Y+ E ++D EP +I+ ST R +F +LQ R
Sbjct: 296 -NPDNHAHYT-----EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLR 349
Query: 365 SEALRRQQL 373
E R ++
Sbjct: 350 KETEARDEM 358
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 263 bits (672), Expect = 8e-70
Identities = 149/369 (40%), Positives = 224/369 (60%), Gaps = 38/369 (10%)
Query: 19 RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKYS 77
R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + GD+ I+QEI M+K+
Sbjct: 14 RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73
Query: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T L E IAY+CRE
Sbjct: 74 HC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRET 124
Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL++LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+ +R +FIGTPYWMAP
Sbjct: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 255
EV A ++N Y+ D+W++GITAIE+ E PP+ D+HPMRALFL+ ++ P+LK
Sbjct: 185 EVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242
Query: 256 K-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314
K KWS F +F++ L KN +RP E+L+ H F+ R + ++L D ++
Sbjct: 243 KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN------- 295
Query: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRR----------DFLRLQLANKER 364
+ Y+ E ++D EP +I+ ST R +F +LQ R
Sbjct: 296 -NPDNHAHYT-----EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLR 349
Query: 365 SEALRRQQL 373
E R ++
Sbjct: 350 KETEARDEM 358
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 260 bits (665), Expect = 5e-69
Identities = 149/338 (44%), Positives = 208/338 (61%), Gaps = 24/338 (7%)
Query: 2 ASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGD 61
A S + L E L+ + P +F+++E +G G+YG V+K H ++GQ+ AIK + V D
Sbjct: 6 APKSKLKKLSEDSLT--KQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD 63
Query: 62 EEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTK 121
+E IK EI+++++ + YYG++ K LW+VME+CGAGSV+D+I+ +
Sbjct: 64 LQEIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LR 114
Query: 122 GNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
TL E+ IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T
Sbjct: 115 NKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDT 174
Query: 182 VGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA 241
+ +RNT IGTP+WMAPEVI + Y+ +D+WSLGIT+IEMAEG PP D+HPMRA
Sbjct: 175 MAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRA 229
Query: 242 LFLIPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
+F+IP NP P K + WS F F++ CLVKN QR QL++HPFI+ N + V I
Sbjct: 230 IFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK---NAKPVSI 286
Query: 301 QLKDHIDRT---KKKRGEKDETEYEYSGSEEEEEENDS 335
L+D I K KR E+ + E E +E+E DS
Sbjct: 287 -LRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDS 323
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 259 bits (663), Expect = 9e-69
Identities = 142/319 (44%), Positives = 202/319 (63%), Gaps = 19/319 (5%)
Query: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77
DP +F ++ +G G++G+VYKG T ++ AIK++D+ DE E+I+QEI +L +
Sbjct: 15 DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
Query: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
I Y+G+++K +LW++ME+ G GS DL+K L+E +IA I REI
Sbjct: 75 SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124
Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH + IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184
Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
EVI + YDFK+D+WSLGITAIE+A+G PP D+HPMR LFLIP+N P L+ +
Sbjct: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239
Query: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
SK F+ F+E+CL K+ RP ++L+KH FI + +L D R K + G +
Sbjct: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSE-GHGE 297
Query: 318 ETEYEYSGSEEEEEENDSG 336
E+ E S + E E+ + G
Sbjct: 298 ESSSEDSDIDGEAEDGEQG 316
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 259 bits (661), Expect = 2e-68
Identities = 141/320 (44%), Positives = 201/320 (62%), Gaps = 18/320 (5%)
Query: 18 LRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKK 75
+ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ DE E+I+QEI +L +
Sbjct: 17 IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76
Query: 76 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
+ YYG+++K + +LW++ME+ G GS DL++ E IA + +
Sbjct: 77 CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126
Query: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
EIL+GL +LH K IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WM
Sbjct: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186
Query: 196 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS 255
APEVI + YD K+D+WSLGITAIE+A+G PP DMHPMR LFLIP+N P L
Sbjct: 187 APEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG 241
Query: 256 KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315
++K F+ FI++CL K+ S RP ++L+KH FI + +L D R K +
Sbjct: 242 -DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300
Query: 316 KDETEYEYSGSEEEEEENDS 335
DE++ E S SE EN++
Sbjct: 301 DDESDSEGSDSESTSRENNT 320
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 253 bits (647), Expect = 7e-67
Identities = 141/317 (44%), Positives = 201/317 (63%), Gaps = 24/317 (7%)
Query: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77
DP +F +E +G G++G+V+KG +T ++ AIK++D+ DE E+I+QEI +L +
Sbjct: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 79 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128
Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH K IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188
Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
EVI + YD K+D+WSLGITAIE+A G PP ++HPM+ LFLIP+N P L+
Sbjct: 189 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 242
Query: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
+SK + F+E+CL K S RP ++L+KH FI + +L IDR K+ + E+
Sbjct: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQ- 298
Query: 318 ETEYEYSGSEEEEEEND 334
++ S SE+ + E D
Sbjct: 299 --SHDDSSSEDSDAETD 313
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 253 bits (647), Expect = 7e-67
Identities = 141/317 (44%), Positives = 201/317 (63%), Gaps = 24/317 (7%)
Query: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77
DP +F +E +G G++G+V+KG +T ++ AIK++D+ DE E+I+QEI +L +
Sbjct: 31 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 90
Query: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 91 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 140
Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH K IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 141 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 200
Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
EVI + YD K+D+WSLGITAIE+A G PP ++HPM+ LFLIP+N P L+
Sbjct: 201 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 254
Query: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
+SK + F+E+CL K S RP ++L+KH FI + +L IDR K+ + E+
Sbjct: 255 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQ- 310
Query: 318 ETEYEYSGSEEEEEEND 334
++ S SE+ + E D
Sbjct: 311 --SHDDSSSEDSDAETD 325
>gi|45439370 TAO kinase 1 [Homo sapiens]
Length = 1001
Score = 251 bits (641), Expect = 3e-66
Identities = 188/611 (30%), Positives = 304/611 (49%), Gaps = 93/611 (15%)
Query: 1 MASDSPARSLDEIDLSAL---RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
M S + A SL + +++ L DP +F + +G+G++G VY R V+T ++ AIK M
Sbjct: 1 MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMS 60
Query: 58 VTGDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSV 113
+G + E I +E+ L++ H +I Y G +++++ WLVME+C GS
Sbjct: 61 YSGKQSTEKWQDIIKEVKFLQRIKHPNSIE-YKGCYLREHTA------WLVMEYC-LGSA 112
Query: 114 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFG 173
+DL++ K L+E IA I L+GL++LH H +IHRDIK N+LLTE +VKL DFG
Sbjct: 113 SDLLEVHK-KPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFG 171
Query: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
++ N+F+GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PP
Sbjct: 172 SASMASPA----NSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
Query: 233 LCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-RD 291
L +M+ M AL+ I +N +P L+S +WS F++F++SCL K RP +E+L+KH F+ R+
Sbjct: 225 LFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRE 284
Query: 292 QPNERQVRIQLKDHIDRTKKKRGEKDETEYE----------YSG----SEEEEEENDSG- 336
+P L D I RTK E D +Y ++G ++EEEEE D G
Sbjct: 285 RP-----ETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGV 339
Query: 337 ------------------------EPSSILNLPGESTLRRDFLRLQ---LANKERSEALR 369
+ SS+ +LP S + + ++ S
Sbjct: 340 GRTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHL 399
Query: 370 RQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLE---------------EQQRREKE 414
+ + E + E + R + ++ K R E ++ ++ E
Sbjct: 400 KPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSE 459
Query: 415 LRKQQE--REQRRHYEEQMRREEERRRAEHEQEYIR--RQLEEEQRQLEILQQQLL--HE 468
LR+Q + RR +++Q+ E + +AE ++ +R + LE ++ ++L+ H+
Sbjct: 460 LREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQ 519
Query: 469 QALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPS 528
A+ E K EE++ + +Q Q K+E + + Q + + R + K + +
Sbjct: 520 AAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKK 579
Query: 529 EKPAWAKEVEE 539
EK W + +E
Sbjct: 580 EKQEWLSKQKE 590
Score = 58.5 bits (140), Expect = 4e-08
Identities = 96/389 (24%), Positives = 156/389 (40%), Gaps = 89/389 (22%)
Query: 260 KKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI-QLKDHIDRT-----KKKR 313
KKFQ I+ A ++ + F+ Q E ++R QLK+ ++ K+K+
Sbjct: 534 KKFQQHIQ-----------AQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQ 582
Query: 314 GEKDETEYEYSGSEEEEEENDSGEPSSILNLP----------GESTLRRDFLRLQLANKE 363
+ + + EEE N L L G L +D +R +L ++
Sbjct: 583 EWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQ 642
Query: 364 RSEALRRQQLEQQQRENEEHKRQLLAERQK------RIEEQKEQRRRLEEQQRREKELRK 417
+ L L +Q +E + + L QK R++ Q E +LE +RRE+ELR+
Sbjct: 643 TQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRR 702
Query: 418 QQEREQRRHYEEQMRRE--------------------------EERRRAEHEQEYIRRQL 451
+ E R+ + +E E ++EH+ ++R
Sbjct: 703 KHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKA-VLKRLK 761
Query: 452 EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAE--RLQRQLKQERDYL--------- 500
EE+ R+L IL +Q H +L + +L+E ++AE L+ QL+QE + L
Sbjct: 762 EEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKM 821
Query: 501 -VSLQHQRQ----EQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSR--LNRQS------ 547
QH R+ EQR ++ L K E A E ER R L RQ+
Sbjct: 822 QAEAQHDRELRELEQRVSLRRALLEQK---IEEEMLALQNERTERIRSLLERQAREIEAF 878
Query: 548 -SPAMPHKVANRISDPNLPPRSESFSISG 575
S +M +N + NL P + S S G
Sbjct: 879 DSESMRLGFSNMVLS-NLSPEAFSHSYPG 906
Score = 40.0 bits (92), Expect = 0.015
Identities = 55/286 (19%), Positives = 117/286 (40%), Gaps = 65/286 (22%)
Query: 280 TEQLMKHPF---IRDQPN--ERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEND 334
T Q+ +H +R+Q + +R R K + K + E DE E + N
Sbjct: 448 TRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNF 507
Query: 335 SGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKR 394
+ E ++ ++ +A ++ + E ++ ++ + A+++K
Sbjct: 508 AAEMEKLI--------------------KKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKE 547
Query: 395 IEEQKEQRRRLEEQQRRE--KE----------------LRKQQE--------------RE 422
+ E ++R E + R+E KE L KQ+E R
Sbjct: 548 LNSFLESQKR-EYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRR 606
Query: 423 QRRHYEEQMRREEERR---RAEHEQEYIRRQLEEEQRQLEILQQQLL--HEQALLLEYKR 477
QR++ E + RR + R R EQ+ +R +L + Q Q ++ LL HE LE++
Sbjct: 607 QRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRH 666
Query: 478 KQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKE 523
++ + E + +L+ + + L++ ++ +R + +K + ++
Sbjct: 667 LNTIQKMRCELI--RLQHQTELTNQLEYNKRRERELRRKHVMEVRQ 710
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 249 bits (637), Expect = 1e-65
Identities = 129/280 (46%), Positives = 184/280 (65%), Gaps = 15/280 (5%)
Query: 17 ALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKK 75
+L+DP FEL++ VG GTYG VYK R T +LAA+K++ + GD+ ++QEI +L++
Sbjct: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67
Query: 76 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
H N+ Y G++++ +D+LW+ MEFCG GS+ ++ T L+E IAY+CR
Sbjct: 68 -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118
Query: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
E L+GL HLH IHRDIKG N+LLT +VKL DFGVS +L +V +R +FIGTPYWM
Sbjct: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178
Query: 196 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRL 253
APEV A + Y+ D+W+LGITAIE+ E PPL +HPMRAL L+ ++ P+L
Sbjct: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236
Query: 254 KSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQ 292
+ K +W++ F F++ L KN +RP E+L++HPF Q
Sbjct: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ 276
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,765,035
Number of Sequences: 37866
Number of extensions: 2919614
Number of successful extensions: 71178
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1607
Number of HSP's successfully gapped in prelim test: 1787
Number of HSP's that attempted gapping in prelim test: 18879
Number of HSP's gapped (non-prelim): 20257
length of query: 1352
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1238
effective length of database: 13,930,794
effective search space: 17246322972
effective search space used: 17246322972
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.