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Search of human proteins with 239047795
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239047795 pleckstrin homology domain containing, family A
member 7 [Homo sapiens]
(1121 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239047795 pleckstrin homology domain containing, family A mem... 2287 0.0
gi|19923493 pleckstrin homology domain containing, family A memb... 439 e-123
gi|219689123 pleckstrin homology domain containing, family A mem... 356 6e-98
gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo ... 325 1e-88
gi|238859651 pleckstrin homology domain containing family A memb... 176 8e-44
gi|238859653 pleckstrin homology domain containing family A memb... 173 9e-43
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 70 1e-11
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 67 9e-11
gi|29789058 WW and C2 domain containing 1 isoform 3 [Homo sapiens] 64 8e-10
gi|242247257 WW and C2 domain containing 1 isoform 2 [Homo sapiens] 64 8e-10
gi|242247251 WW and C2 domain containing 1 isoform 1 [Homo sapiens] 64 8e-10
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 63 2e-09
gi|46852390 coiled-coil domain containing 6 [Homo sapiens] 62 2e-09
gi|8670546 cytohesin 2 isoform 1 [Homo sapiens] 61 7e-09
gi|156546890 WW and C2 domain containing 2 [Homo sapiens] 60 2e-08
gi|222352183 neural precursor cell expressed, developmentally do... 59 3e-08
gi|21361472 neural precursor cell expressed, developmentally dow... 59 3e-08
gi|222352094 neural precursor cell expressed, developmentally do... 59 3e-08
gi|222352092 neural precursor cell expressed, developmentally do... 59 3e-08
gi|222352090 neural precursor cell expressed, developmentally do... 59 3e-08
gi|222352088 neural precursor cell expressed, developmentally do... 59 3e-08
gi|222352086 neural precursor cell expressed, developmentally do... 59 3e-08
gi|222352084 neural precursor cell expressed, developmentally do... 59 3e-08
gi|222352082 neural precursor cell expressed, developmentally do... 59 3e-08
gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo s... 59 3e-08
gi|18860884 WW domain-containing oxidoreductase isoform 2 [Homo ... 59 3e-08
gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Ho... 59 3e-08
gi|224451082 cytospin A [Homo sapiens] 57 1e-07
gi|224451080 cytospin A [Homo sapiens] 57 1e-07
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 57 1e-07
>gi|239047795 pleckstrin homology domain containing, family A member 7
[Homo sapiens]
Length = 1121
Score = 2287 bits (5927), Expect = 0.0
Identities = 1121/1121 (100%), Positives = 1121/1121 (100%)
Query: 1 MAAATVGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRSDLPRGW 60
MAAATVGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRSDLPRGW
Sbjct: 1 MAAATVGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRSDLPRGW 60
Query: 61 EEGFTEEGASYFIDHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQDRNQRPSSMV 120
EEGFTEEGASYFIDHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQDRNQRPSSMV
Sbjct: 61 EEGFTEEGASYFIDHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQDRNQRPSSMV 120
Query: 121 SETSTAGTASTLEAKPGPKIIKSSSKVHSFGKRDQAIRRNPNVPVVVRGWLHKQDSSGMR 180
SETSTAGTASTLEAKPGPKIIKSSSKVHSFGKRDQAIRRNPNVPVVVRGWLHKQDSSGMR
Sbjct: 121 SETSTAGTASTLEAKPGPKIIKSSSKVHSFGKRDQAIRRNPNVPVVVRGWLHKQDSSGMR 180
Query: 181 LWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRA 240
LWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRA
Sbjct: 181 LWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRA 240
Query: 241 LIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDMEKVERQA 300
LIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDMEKVERQA
Sbjct: 241 LIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDMEKVERQA 300
Query: 301 VPQANHTESCHECGRVGPGHTRDCPHRGHDDIVNFERQEQEGEQYRSQRDPLEGKRDRSK 360
VPQANHTESCHECGRVGPGHTRDCPHRGHDDIVNFERQEQEGEQYRSQRDPLEGKRDRSK
Sbjct: 301 VPQANHTESCHECGRVGPGHTRDCPHRGHDDIVNFERQEQEGEQYRSQRDPLEGKRDRSK 360
Query: 361 ARSPYSPAEEDALFMDLPTGPRGQQAQPQRAEKNGMLPASYGPGEQNGTGGYQRAFPPRT 420
ARSPYSPAEEDALFMDLPTGPRGQQAQPQRAEKNGMLPASYGPGEQNGTGGYQRAFPPRT
Sbjct: 361 ARSPYSPAEEDALFMDLPTGPRGQQAQPQRAEKNGMLPASYGPGEQNGTGGYQRAFPPRT 420
Query: 421 NPEKHSQRKSNLAQVEHWARAQKGDSRSLPLDQTLPRQGPGQSLSFPENYQTLPKSTRHP 480
NPEKHSQRKSNLAQVEHWARAQKGDSRSLPLDQTLPRQGPGQSLSFPENYQTLPKSTRHP
Sbjct: 421 NPEKHSQRKSNLAQVEHWARAQKGDSRSLPLDQTLPRQGPGQSLSFPENYQTLPKSTRHP 480
Query: 481 SGGSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAP 540
SGGSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAP
Sbjct: 481 SGGSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAP 540
Query: 541 ICLGSPEFTDQGRSRSMLEVPRSISVPPSPSDIPPPGPPRVFPPRRPHTPAERVTVKPPD 600
ICLGSPEFTDQGRSRSMLEVPRSISVPPSPSDIPPPGPPRVFPPRRPHTPAERVTVKPPD
Sbjct: 541 ICLGSPEFTDQGRSRSMLEVPRSISVPPSPSDIPPPGPPRVFPPRRPHTPAERVTVKPPD 600
Query: 601 QRRSVDISLGDSPRRARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLK 660
QRRSVDISLGDSPRRARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLK
Sbjct: 601 QRRSVDISLGDSPRRARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLK 660
Query: 661 KDLEYLDLKMTGRDLLKDRSLKPVKIAESDTDVKLSIFCEQDRVLQDLEDKIRALKENKD 720
KDLEYLDLKMTGRDLLKDRSLKPVKIAESDTDVKLSIFCEQDRVLQDLEDKIRALKENKD
Sbjct: 661 KDLEYLDLKMTGRDLLKDRSLKPVKIAESDTDVKLSIFCEQDRVLQDLEDKIRALKENKD 720
Query: 721 QLESVLEVLHRQMEQYRDQPQHLEKIAYQQKLLQEDLVHIRAELSRESTEMENAWNEYLK 780
QLESVLEVLHRQMEQYRDQPQHLEKIAYQQKLLQEDLVHIRAELSRESTEMENAWNEYLK
Sbjct: 721 QLESVLEVLHRQMEQYRDQPQHLEKIAYQQKLLQEDLVHIRAELSRESTEMENAWNEYLK 780
Query: 781 LENDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVTAGLSANKENFRILVESVKNPE 840
LENDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVTAGLSANKENFRILVESVKNPE
Sbjct: 781 LENDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVTAGLSANKENFRILVESVKNPE 840
Query: 841 RKTVPLFPHPPVPSLSTSESKPPPQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRK 900
RKTVPLFPHPPVPSLSTSESKPPPQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRK
Sbjct: 841 RKTVPLFPHPPVPSLSTSESKPPPQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRK 900
Query: 901 VTSPLQSPTKAKPKVEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQS 960
VTSPLQSPTKAKPKVEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQS
Sbjct: 901 VTSPLQSPTKAKPKVEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQS 960
Query: 961 DERKRDRELGQCVNGDSRVELRSYVSEPELATLSGDMAQPSLGLVGPESRYQTLPGRGLS 1020
DERKRDRELGQCVNGDSRVELRSYVSEPELATLSGDMAQPSLGLVGPESRYQTLPGRGLS
Sbjct: 961 DERKRDRELGQCVNGDSRVELRSYVSEPELATLSGDMAQPSLGLVGPESRYQTLPGRGLS 1020
Query: 1021 GSTSRLQQSSTIAPYVTLRRGLNAESSKATFPRPKSALERLYSGDHQRGKMSAEEQLERM 1080
GSTSRLQQSSTIAPYVTLRRGLNAESSKATFPRPKSALERLYSGDHQRGKMSAEEQLERM
Sbjct: 1021 GSTSRLQQSSTIAPYVTLRRGLNAESSKATFPRPKSALERLYSGDHQRGKMSAEEQLERM 1080
Query: 1081 KRHQKALVRERKRTLGQGERTGLPSSRYLSRPLPGDLGSVC 1121
KRHQKALVRERKRTLGQGERTGLPSSRYLSRPLPGDLGSVC
Sbjct: 1081 KRHQKALVRERKRTLGQGERTGLPSSRYLSRPLPGDLGSVC 1121
>gi|19923493 pleckstrin homology domain containing, family A member
5 isoform 1 [Homo sapiens]
Length = 1116
Score = 439 bits (1129), Expect = e-123
Identities = 304/843 (36%), Positives = 437/843 (51%), Gaps = 101/843 (11%)
Query: 10 TLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRS-DLPRGWEEGFTEEG 68
+LP W+YG+ R GRVFFIN++ + TTWLHP TGE V +GH +S DLP GWEE +T EG
Sbjct: 11 SLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEG 70
Query: 69 ASYFIDHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQDRNQRPSSMVSETSTAGT 128
A Y+I+HN++ +HPVTGQ S +N F++ E+ M+ +++ +RP SM++E S
Sbjct: 71 ARYYINHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERPISMINEASNYNV 130
Query: 129 ASTLEAKPGPKI---IKSSSKVHSFGKRDQAIRRNPNVPVVVRGWLHKQDSSGMRLWKRR 185
S P + ++S KVH+FGKR +I+RNPN PVV RGWL+KQDS+GM+LWK+R
Sbjct: 131 TSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKR 190
Query: 186 WFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYNS 245
WFVL+D CLFYY+D +EE +LGSI LPS+ I+ + ED I+RKY+FKA H
Sbjct: 191 WFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAH---------- 240
Query: 246 STAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDMEKVERQAVPQAN 305
MRTYYF DT ++M W++AM AA ++ +KR ++K+ + P
Sbjct: 241 ---------PNMRTYYFCTDTGKEMELWMKAMLDAA-LVQTEPVKR-VDKITSENAPTKE 289
Query: 306 HTESCHECGRVGPGHTRDCPHRGHDDIVNFERQEQEGEQYRSQRD----PLEGKRDRSKA 361
+ + P + ++ I E++ E E+Y Q+D PL K + K
Sbjct: 290 TNNIPNHRVLIKPEIQNNQKNKEMSKIE--EKKALEAEKYGFQKDGQDRPLT-KINSVKL 346
Query: 362 RSPYSPAEEDALFMDLPTGPRGQQAQPQRAEKNGMLPASYGPGEQNGTGGYQRAFPPRTN 421
S S E + R + + A G + TG P T
Sbjct: 347 NSLPSEYESGSACPAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTG------PLYTE 400
Query: 422 PEKHSQRKSNLAQVEHWARAQKG-----DSRSLPLDQTLPRQGPGQSLS----FPENYQT 472
++ QR +++ Q+E W + QKG ++R + QTLPR P +PE Y+T
Sbjct: 401 ADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRT 460
Query: 473 LPKSTRHPSGGSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQF 532
LP++ S P ++ S D+ + E+RR+ RD T+WQLYEWQQR QF
Sbjct: 461 LPRN-------SKTRPESICSVTPSTHDKTLG-PGAEEKRRSMRDDTMWQLYEWQQR-QF 511
Query: 533 RHGSPTAP--ICLGSPEFTDQGRSRSMLEVPRSISVPPSPSDIPPPGPPRVFPPRRPHTP 590
+ T P L SP+ ++M +P S PS I + + P+R +
Sbjct: 512 YNKQSTLPRHSTLSSPKTMVNISDQTMHSIPTS----PSHGSI---AAYQGYSPQRTY-- 562
Query: 591 AERVTVKPPDQRRSVDISLGDSPRRARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHGK 650
R V P QR V I RR R H K+ DRRS+P+ G +VS SL GK
Sbjct: 563 --RSEVSSPIQRGDVTID-----RRHRAHHPKHVYVPDRRSVPA-GLTLQSVSPQSLQGK 614
Query: 651 SADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPVKIAESDTDVKLSIFCEQDRVLQDLED 710
+ L +D GR +L + E D D KLS CEQD+V+ LE+
Sbjct: 615 T-------LSQD--------EGRG-----TLYKYRPEEVDIDAKLSRLCEQDKVVHALEE 654
Query: 711 KIRALKENKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQKLLQEDLVHIRAELSRESTE 770
K++ L + K LE L +++E + D P ++ + Q+ LQ L+ ELSR + E
Sbjct: 655 KLQQLHKEKYTLEQALLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAE 714
Query: 771 MENAWNEYLKLENDVEQLKQTLQEQHRRAFFFQ------EKSQIQKDLWRIEDVTAGLSA 824
+E AW EY KLE DV + +QEQ Q +++QIQK+LWRI+DV GLS
Sbjct: 715 LERAWREYDKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSK 774
Query: 825 NKE 827
+K+
Sbjct: 775 HKQ 777
Score = 63.5 bits (153), Expect = 1e-09
Identities = 44/124 (35%), Positives = 66/124 (53%), Gaps = 10/124 (8%)
Query: 980 ELRSYVSEPELATLSGDMAQPSLGLVGPESRYQTLPGRGLS--------GSTSRLQQSST 1031
+ R Y SEPEL T++ P S +T +G + S +SST
Sbjct: 803 DYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPTPESST 862
Query: 1032 IAPYVTLRRGLNAESSKATFPRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRER 1091
IA YVTLR+ + RP+SA+E+L + R +M+ EEQ+ER++RHQ+A +RE+
Sbjct: 863 IASYVTLRKTKKMMDLRTE--RPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACLREK 920
Query: 1092 KRTL 1095
K+ L
Sbjct: 921 KKGL 924
>gi|219689123 pleckstrin homology domain containing, family A member
5 isoform 2 [Homo sapiens]
Length = 1105
Score = 356 bits (914), Expect = 6e-98
Identities = 296/928 (31%), Positives = 436/928 (46%), Gaps = 131/928 (14%)
Query: 107 MSKQDRNQRPSSMVSETSTAGTASTLEAKPGPKI---IKSSSKVHSFGKRDQAIRRNPNV 163
M+ +++ +RP SM++E S S P + ++S KVH+FGKR +I+RNPN
Sbjct: 1 MTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNA 60
Query: 164 PVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPED 223
PVV RGWL+KQDS+GM+LWK+RWFVL+D CLFYY+D +EE +LGSI LPS+ I+ + ED
Sbjct: 61 PVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSED 120
Query: 224 RISRKYSFKAVHTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQV 283
I+RKY+FKA H MR TYYF DT ++M W++AM AA V
Sbjct: 121 HINRKYAFKAAHPNMR-------------------TYYFCTDTGKEMELWMKAMLDAALV 161
Query: 284 LSRSSLKRDMEKVERQAVPQANHTESCHECGRVGPGHTRDCPHRGHDDIVNFERQEQEGE 343
+ +KR ++K+ + P + + P + ++ I E++ E E
Sbjct: 162 QTEP-VKR-VDKITSENAPTKETNNIPNHRVLIKPEIQNNQKNKEMSKIE--EKKALEAE 217
Query: 344 QYRSQRD----PLEGKRDRSKARSPYSPAEEDALFMDLPTGPRGQQAQPQRAEKNGMLPA 399
+Y Q+D PL K + K S S E + R + + A
Sbjct: 218 KYGFQKDGQDRPLT-KINSVKLNSLPSEYESGSACPAQTVHYRPINLSSSENKIVNVSLA 276
Query: 400 SYGPGEQNGTGGYQRAFPPRTNPEKHSQRKSNLAQVEHWARAQKG-----DSRSLPLDQT 454
G + TG P T ++ QR +++ Q+E W + QKG ++R + QT
Sbjct: 277 DLRGGNRPNTG------PLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQT 330
Query: 455 LPRQGPGQSLS----FPENYQTLPKSTRHPSGGSSPPPRNLPSDYKYAQDRASHLKMSSE 510
LPR P +PE Y+TLP++ S P ++ S D+ + E
Sbjct: 331 LPRNMPSHRAQIMARYPEGYRTLPRN-------SKTRPESICSVTPSTHDKTLG-PGAEE 382
Query: 511 ERRAHRDGTVWQLYEWQQRQQFRHGSPTAP--ICLGSPEFTDQGRSRSMLEVPRSISVPP 568
+RR+ RD T+WQLYEWQQRQ F + T P L SP+ ++M +P S P
Sbjct: 383 KRRSMRDDTMWQLYEWQQRQ-FYNKQSTLPRHSTLSSPKTMVNISDQTMHSIPTS----P 437
Query: 569 SPSDIPPPGPPRVFPPRRPHTPAERVTVKPPDQRRSVDISLGDSPRRARGHAVKNSSHVD 628
S I + + P+R + R V P QR V I RR R H K+ D
Sbjct: 438 SHGSI---AAYQGYSPQRTY----RSEVSSPIQRGDVTID-----RRHRAHHPKHVYVPD 485
Query: 629 RRSMPSMGYMTHTVSAPSLHGKSADDT--------------------YLQLKKDLEYLDL 668
RRS+P+ G +VS SL GK+ + Y Q + + L
Sbjct: 486 RRSVPA-GLTLQSVSPQSLQGKTMKENEPIITMVHTMIENSALRPQLYQQFLRQKSKISL 544
Query: 669 KMTGRDLLKDRSLKPVKIAESDTDVKLSIFCEQDRVLQDLEDKIRALKENKDQLESVLEV 728
+D + +L + E D D KLS CEQD+V+ LE+K++ L + K LE L
Sbjct: 545 YCLSQDEGRG-TLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLS 603
Query: 729 LHRQMEQYRDQPQHLEKIAYQQKLLQEDLVHIRAELSRESTEMENAWNEYLKLENDVEQL 788
+++E + D P ++ + Q+ LQ L+ ELSR + E+E AW EY KLE DV
Sbjct: 604 ASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVT 663
Query: 789 KQTLQEQHRRAFFFQ------EKSQIQKDLWRIEDVTAGLSANKENFRIL------VESV 836
+ +QEQ Q +++QIQK+LWRI+DV GLS +K+ ++
Sbjct: 664 RNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGMIGSKPFSTVKY 723
Query: 837 KNPERKTVPLFPHPPVP-SLSTSESKP--PPQPSPPTS-------PVRTPLEVRLFPQLQ 886
KN E + VP P PP+P S +E P PP PS +S PV P E +++ Q+Q
Sbjct: 724 KNEEEEVVP--PRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEEKKMY-QVQ 780
Query: 887 TYVPYRPH-PPQLRKVTSPLQSPTKAKPKVEDEAPPRPPLPELYSPEDQ----------P 935
Y H P R S + T A+ + P+ E+ + + P
Sbjct: 781 GYPRNGSHCGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPP 840
Query: 936 PAVPPLPREATIIRHTSVRGLKRQSDER 963
A P P +TI + ++R K+ D R
Sbjct: 841 RAKSPTPESSTIASYVTLRKTKKMMDLR 868
>gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo
sapiens]
Length = 1048
Score = 325 bits (833), Expect = 1e-88
Identities = 292/1034 (28%), Positives = 451/1034 (43%), Gaps = 236/1034 (22%)
Query: 107 MSKQDRNQRPSSMVSETSTAGTASTLEA-KPGPKIIKSSSKVHSFGKRDQAIRRNPNVPV 165
MS + +RP++ S+ S + +P + +++ K +FGKR +++RNPN PV
Sbjct: 1 MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAVAFGKRSHSMKRNPNAPV 60
Query: 166 VVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRI 225
GWL KQ SSG++ W +RWFVL D CLFYYKD +EE++LGSIPL S+ ++ V P D I
Sbjct: 61 TKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI 120
Query: 226 SRKYSFKAVHTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQV-- 283
SRK++FKA H +G+RTY+FSA++ E+ AW++AM +AA+V
Sbjct: 121 SRKHTFKAEH-------------------AGVRTYFFSAESPEEQEAWIQAMGEAARVQI 161
Query: 284 -----LSRSSLKRDMEKVERQAVPQANHTESCHECGRVGPGHTRDCPHRGHDDIVNFERQ 338
+++ EK + + VP + H + P + RG D E+
Sbjct: 162 PPAQKSVPQAVRHSHEKPDSENVPPSKHHQQPPHNSL--PKPEPEAKTRGEGDGRGCEKA 219
Query: 339 EQEGEQYRSQRDP-------LEGKRDRSKARSPYSPAEEDALFMDLPTGPRGQQAQPQRA 391
E+ E+ +++P G S+ SPY P GPR Q A
Sbjct: 220 ERRPERPEVKKEPPVKANGLPAGPEPASEPGSPY------------PEGPRVPGGGEQPA 267
Query: 392 EKNGM---LPASYG----PGEQNGTGGYQRAFPPRTNPEKHSQRKSNLAQVEHWARAQKG 444
+ NG P+ G P + TGG++R+FPPRTNP+K +QRKS++ Q++ W ++G
Sbjct: 268 QPNGWQYHSPSRPGSTAFPSQDGETGGHRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRG 327
Query: 445 ---------DSRSLPLDQTLPRQGPGQSLSFPENYQTLPKSTRHPSGGSSPPPRNLPSDY 495
SR P+ + +P S +P++YQ P R S S P
Sbjct: 328 VPPPEDLRSPSRFYPVSRRVPEYYGPYSSQYPDDYQYYPPGVRPESICSMP--------- 378
Query: 496 KYAQDRASHLKMSSEERRAHRD--GTVWQLYEWQQRQQFRHGSPTA--PICLGSPEFTDQ 551
A DR S ++R A R+ G +QL EW++ + T P P + D+
Sbjct: 379 --AYDRISPPWALEDKRHAFRNGGGPAYQLREWKEPASYGRQDATVWIPSPSRQPVYYDE 436
Query: 552 -----GRSRSMLEVPRSISVPPSPSDIPPPGPPRVFPPRRPHTPAERVTVKPPDQRRSVD 606
R + PRS SVP SPS R++ P R +P+ R PP RS D
Sbjct: 437 LDAASSSLRRLSLQPRSHSVPRSPSQ-GSYSRARIYSPVR--SPSARFERLPP---RSED 490
Query: 607 ISLGDSPRRARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLKKDLEYL 666
I + D P+ M ++S+P + Y ++ +D
Sbjct: 491 I------------------YAD----PAAYVMRRSISSPKV------PPYPEVFRD---- 518
Query: 667 DLKMTGRDLLKDRSLKPVKIAESDTDVKLSIFCEQDRVLQDLEDKIRALKENKDQLESVL 726
SL K+ E DTD L CEQ++V+++ + ++ L+ K+ LES L
Sbjct: 519 -------------SLHTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRAEKESLESAL 565
Query: 727 EVLHRQMEQYRDQPQHLEKIAYQQKLLQEDLVHIRAELSRESTEMENAWNEYLKLENDVE 786
H+++E + QP + EK+ +++ LQ L++IR ELS+ +T + N+ EY LE++V
Sbjct: 566 MGTHQELEMFGSQPAYPEKLRHKKDSLQNQLINIRVELSQATTALTNSTIEYEHLESEVS 625
Query: 787 QLKQTLQEQHRRAFFFQE-KSQIQKDLWRIEDVTAGLSANKENFRILVESVKNPERKTVP 845
L L EQ + QIQK++WRI+DV GL N NP R T
Sbjct: 626 ALHDDLWEQLNLDTQNEVLNRQIQKEIWRIQDVMEGLRKN------------NPSRGTDT 673
Query: 846 LFPHPPVPSLSTSESKPPPQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVTSPL 905
+ +T S P P S + +PL V+
Sbjct: 674 AKHRGGLGPSATYSSNSPASPLSSAS-LTSPLS------------------PFSLVSGSQ 714
Query: 906 QSPTKA---KPKVEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQSDE 962
SPTK +PK E + P L P D P + +P RQ E
Sbjct: 715 GSPTKPGSNEPKANYEQSKKDPHQTL--PLDTPRDISLVP--------------TRQEVE 758
Query: 963 RKRDRELGQCVNGDSRVELRSYVSEPELATLSGDMAQPSLGLVGPESRYQTLPGRGLSGS 1022
++ L + +G+V P ++ T
Sbjct: 759 AEKQAALNK------------------------------VGVVPPRTKSPT--------- 779
Query: 1023 TSRLQQSSTIAPYVTLRRGLNA-ESSKATFPRPKSALERLYSGDHQRGKMSAEEQLERMK 1081
+ P +RR + + ++ RPKSA ++ G+ + KMS EEQ++RM+
Sbjct: 780 ------DDEVTPSAVVRRNASGLTNGLSSQERPKSA---VFPGE-GKVKMSVEEQIDRMR 829
Query: 1082 RHQKALVRERKRTL 1095
RHQ +RE++R+L
Sbjct: 830 RHQSGSMREKRRSL 843
>gi|238859651 pleckstrin homology domain containing family A member
4 isoform 1 [Homo sapiens]
Length = 779
Score = 176 bits (447), Expect = 8e-44
Identities = 127/365 (34%), Positives = 174/365 (47%), Gaps = 38/365 (10%)
Query: 115 RPSSMVSETSTAGTASTLEAKPGPKIIKSSSKVHSFGKRDQAIRRNPNVPVVVRGWLHKQ 174
RP S +S S+A T S+L + K ++ +K+H+FGKR A+RR+PN+PV +RGWLHKQ
Sbjct: 5 RPRSSLSLASSASTISSLSSLSPKKPTRAVNKIHAFGKRGNALRRDPNLPVHIRGWLHKQ 64
Query: 175 DSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAV 234
DSSG+RLWKRRWFVL+ +CLFYYKDSREE+VLGS+ LPSY I P P R+++F A
Sbjct: 65 DSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFTFTAE 124
Query: 235 HTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQV----LSRSSLK 290
H GMRTY +ADT ED+ W+RA+ +A++ +
Sbjct: 125 H-------------------PGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSP 165
Query: 291 RDMEKVERQAVPQANHTESCHECGRV--GPGHTRDCPHRGHDDIV--NFERQEQEGEQYR 346
+ E P S E GR+ P TR RG ++ + G Q R
Sbjct: 166 ARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMR 225
Query: 347 SQRDPLEGKRDRSKARSPYSPAEEDALFMDLPTGPRGQQAQPQR-----AEKNGMLPASY 401
R P + S+ SP S + P P G A P R + + P +
Sbjct: 226 RARSP-DLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDW 284
Query: 402 GPGEQNGTGGYQRAFPPRTNPEKHSQRKSNLAQVEHWARAQKGDSRS-LPLDQTLPRQGP 460
GP Q R PR P + +HW++ + + S P LP + P
Sbjct: 285 GPQRQT----LSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRPP 340
Query: 461 GQSLS 465
G S
Sbjct: 341 GTRAS 345
Score = 120 bits (301), Expect = 7e-27
Identities = 117/411 (28%), Positives = 169/411 (41%), Gaps = 44/411 (10%)
Query: 474 PKSTRHPSGGSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFR 533
P+S P G P P + EE R V +L + R +
Sbjct: 162 PRSPARPQPGEGPGGPGGPPEVS-----------RGEEGRISESPEVTRLSRGRGRPRLL 210
Query: 534 HGSPTAPICLG-------SPE-FTDQGRSRSMLEVPRSISVPPSPSDIPPPGPPRVFPPR 585
SPT + G SP+ FT R S L +PR S +P+ PP PP
Sbjct: 211 TPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRS---APARRPPAPSGDTAPPA 267
Query: 586 RPHTPAERVTVKPPDQRRSVDISLGDSPRRARGHAVKNSSHVDRRSMPSMGYMTHTVSAP 645
RPHTP R+ V+PP +L P RG + RS H P
Sbjct: 268 RPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQ------HWSQEP 321
Query: 646 SLHGKSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPVKIAESDTDVKLSIFCEQDRVL 705
S TYLQL M LL L+ +TD L+ C QDR+L
Sbjct: 322 RTQAHSGSPTYLQLPPRPPGTRASMV---LLPGPPLESTFHQSLETDTLLTKLCGQDRLL 378
Query: 706 QDLEDKIRALKENKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQKLLQEDLVHIRAELS 765
+ L+++I +E K+QLE+ LE+ +Q+ Q + + +Q+LLQ+ LV +RA L
Sbjct: 379 RRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRAWGRQRLLQDRLVSVRATLC 438
Query: 766 RESTEMENAWNEYLKLENDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVTAGLSAN 825
+ E E W+ Y LE ++ L++TL E Q++ Q+ LW +ED AGL
Sbjct: 439 HLTQERERVWDTYSGLEQELGTLRETL-EYLLHLGSPQDRVSAQQQLWMVEDTLAGLGGP 497
Query: 826 KENFRILVESVKNPERKTVPLFPHPPVPSLSTSESKPPPQPSPPTSPVRTP 876
++ P T P P P + +SE + P+ +SP R+P
Sbjct: 498 QK-----------PPPHTEPDSPSPVLQGEESSERESLPESLELSSP-RSP 536
Score = 33.9 bits (76), Expect = 0.89
Identities = 33/100 (33%), Positives = 42/100 (42%), Gaps = 19/100 (19%)
Query: 853 PSLSTSESKPPPQ---PSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLR-KVTSPL--- 905
P L T S+PP P P ++P R P P T P RPH P R V PL
Sbjct: 230 PDLFTPLSRPPSPLSLPRPRSAPARRPPA----PSGDTAPPARPHTPLSRIDVRPPLDWG 285
Query: 906 -QSPTKAKPKVEDEAPP------RPP-LPELYSPEDQPPA 937
Q T ++P PP +PP P+ +S E + A
Sbjct: 286 PQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQA 325
>gi|238859653 pleckstrin homology domain containing family A member
4 isoform 2 [Homo sapiens]
Length = 583
Score = 173 bits (438), Expect = 9e-43
Identities = 126/356 (35%), Positives = 170/356 (47%), Gaps = 44/356 (12%)
Query: 115 RPSSMVSETSTAGTASTLEAKPGPKIIKSSSKVHSFGKRDQAIRRNPNVPVVVRGWLHKQ 174
RP S +S S+A T S+L + K ++ +K+H+FGKR A+RR+PN+PV +RGWLHKQ
Sbjct: 5 RPRSSLSLASSASTISSLSSLSPKKPTRAVNKIHAFGKRGNALRRDPNLPVHIRGWLHKQ 64
Query: 175 DSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAV 234
DSSG+RLWKRRWFVL+ +CLFYYKDSREE+VLGS+ LPSY I P P R+++F A
Sbjct: 65 DSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFTFTAE 124
Query: 235 HTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQV----LSRSSLK 290
H GMRTY +ADT ED+ W+RA+ +A++ +
Sbjct: 125 H-------------------PGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSP 165
Query: 291 RDMEKVERQAVPQANHTESCHECGRV--GPGHTRDCPHRGHDDIV--NFERQEQEGEQYR 346
+ E P S E GR+ P TR RG ++ + G Q R
Sbjct: 166 ARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMR 225
Query: 347 SQRDPLEGKRDRSKARSPYSPAEEDALFMDLPTGPRGQQAQPQR-----AEKNGMLPASY 401
R P + S+ SP S + P P G A P R + + P +
Sbjct: 226 RARSP-DLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDW 284
Query: 402 GPGEQNGTGGYQRAFPPRTNPEKHSQRKSNLAQVEHWA---RAQKGDSRSLPLDQT 454
GP Q R PR P + +HW+ R Q G PL+ T
Sbjct: 285 GPQRQT----LSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQPGP----PLEST 332
Score = 108 bits (269), Expect = 4e-23
Identities = 110/411 (26%), Positives = 163/411 (39%), Gaps = 69/411 (16%)
Query: 474 PKSTRHPSGGSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFR 533
P+S P G P P + EE R V +L + R +
Sbjct: 162 PRSPARPQPGEGPGGPGGPPEVS-----------RGEEGRISESPEVTRLSRGRGRPRLL 210
Query: 534 HGSPTAPICLG-------SPE-FTDQGRSRSMLEVPRSISVPPSPSDIPPPGPPRVFPPR 585
SPT + G SP+ FT R S L +PR S +P+ PP PP
Sbjct: 211 TPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRS---APARRPPAPSGDTAPPA 267
Query: 586 RPHTPAERVTVKPPDQRRSVDISLGDSPRRARGHAVKNSSHVDRRSMPSMGYMTHTVSAP 645
RPHTP R+ V+PP +L P RG + RS T P
Sbjct: 268 RPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQPGP 327
Query: 646 SLHGKSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPVKIAESDTDVKLSIFCEQDRVL 705
L + T+ Q +TD L+ C QDR+L
Sbjct: 328 PL-----ESTFHQ-----------------------------SLETDTLLTKLCGQDRLL 353
Query: 706 QDLEDKIRALKENKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQKLLQEDLVHIRAELS 765
+ L+++I +E K+QLE+ LE+ +Q+ Q + + +Q+LLQ+ LV +RA L
Sbjct: 354 RRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRAWGRQRLLQDRLVSVRATLC 413
Query: 766 RESTEMENAWNEYLKLENDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVTAGLSAN 825
+ E E W+ Y LE ++ L++TL E Q++ Q+ LW +ED AGL
Sbjct: 414 HLTQERERVWDTYSGLEQELGTLRETL-EYLLHLGSPQDRVSAQQQLWMVEDTLAGLGGP 472
Query: 826 KENFRILVESVKNPERKTVPLFPHPPVPSLSTSESKPPPQPSPPTSPVRTP 876
++ P T P P P + +SE + P+ +SP R+P
Sbjct: 473 QK-----------PPPHTEPDSPSPVLQGEESSERESLPESLELSSP-RSP 511
Score = 37.7 bits (86), Expect = 0.062
Identities = 35/104 (33%), Positives = 44/104 (42%), Gaps = 19/104 (18%)
Query: 853 PSLSTSESKPPPQ---PSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLR-KVTSPL--- 905
P L T S+PP P P ++P R P P T P RPH P R V PL
Sbjct: 230 PDLFTPLSRPPSPLSLPRPRSAPARRPPA----PSGDTAPPARPHTPLSRIDVRPPLDWG 285
Query: 906 -QSPTKAKPKVEDEAPP------RPP-LPELYSPEDQPPAVPPL 941
Q T ++P PP +PP P+ +S E + PPL
Sbjct: 286 PQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQPGPPL 329
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
sapiens]
Length = 862
Score = 70.1 bits (170), Expect = 1e-11
Identities = 33/84 (39%), Positives = 46/84 (54%), Gaps = 5/84 (5%)
Query: 11 LPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRSDLPRGWEEGFTEEGAS 70
LP W +GRV+F+N R T W PR+ G + LP GWE FT +G
Sbjct: 399 LPPGWEKRTDSNGRVYFVNHNTRITQWEDPRS-----QGQLNEKPLPEGWEMRFTVDGIP 453
Query: 71 YFIDHNQQTTAFRHPVTGQFSPEN 94
YF+DHN++TT + P TG+ + +N
Sbjct: 454 YFVDHNRRTTTYIDPRTGKSALDN 477
Score = 47.4 bits (111), Expect = 8e-05
Identities = 51/203 (25%), Positives = 76/203 (37%), Gaps = 50/203 (24%)
Query: 11 LPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRSDLPRGWEEGFTEEGAS 70
LP W V + GRV++++ + TTW P EP LP GWE G
Sbjct: 287 LPPGWEQRVDQHGRVYYVDHVEKRTTWDRP---EP----------LPPGWERRVDNMGRI 333
Query: 71 YFIDHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQDRNQRPSSMVSETSTAGTAS 130
Y++DH +TT ++ P S N E + + Q NQR + T+
Sbjct: 334 YYVDHFTRTTTWQRPTLE--SVRNYEQWQLQRSQLQGAMQQFNQR--FIYGNQDLFATSQ 389
Query: 131 TLEAKP-GPKIIKSSSKVHSFGKRDQAIRRNPNVPVVVRGWLHKQDSSGMRLWKRRWFVL 189
+ E P GP + GW + DS+G R +FV
Sbjct: 390 SKEFDPLGP---------------------------LPPGWEKRTDSNG-----RVYFVN 417
Query: 190 ADYCLFYYKDSREEAVLGSIPLP 212
+ + ++D R + L PLP
Sbjct: 418 HNTRITQWEDPRSQGQLNEKPLP 440
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
[Homo sapiens]
Length = 922
Score = 67.0 bits (162), Expect = 9e-11
Identities = 33/81 (40%), Positives = 41/81 (50%), Gaps = 5/81 (6%)
Query: 11 LPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRSDLPRGWEEGFTEEGAS 70
LP W V RV+F+N + T W PRT G LP GWE +T EG
Sbjct: 458 LPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRT-----QGLQNEEPLPEGWEIRYTREGVR 512
Query: 71 YFIDHNQQTTAFRHPVTGQFS 91
YF+DHN +TT F+ P G+ S
Sbjct: 513 YFVDHNTRTTTFKDPRNGKSS 533
Score = 49.3 bits (116), Expect = 2e-05
Identities = 23/77 (29%), Positives = 35/77 (45%), Gaps = 13/77 (16%)
Query: 9 DTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRSDLPRGWEEGFTEEG 68
+TLP W GR ++++ R TTW P+ LP GWE +
Sbjct: 349 ETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQP-------------LPPGWERRVDDRR 395
Query: 69 ASYFIDHNQQTTAFRHP 85
Y++DHN +TT ++ P
Sbjct: 396 RVYYVDHNTRTTTWQRP 412
Score = 38.9 bits (89), Expect = 0.028
Identities = 15/38 (39%), Positives = 22/38 (57%)
Query: 48 SGHMIRSDLPRGWEEGFTEEGASYFIDHNQQTTAFRHP 85
SG+ LP GWE+ G +Y++DHN +TT + P
Sbjct: 343 SGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERP 380
Score = 31.6 bits (70), Expect = 4.4
Identities = 13/36 (36%), Positives = 20/36 (55%)
Query: 9 DTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGE 44
+ LPE W R+G +F++ R TT+ PR G+
Sbjct: 496 EPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGK 531
>gi|29789058 WW and C2 domain containing 1 isoform 3 [Homo
sapiens]
Length = 1113
Score = 63.9 bits (154), Expect = 8e-10
Identities = 30/77 (38%), Positives = 42/77 (54%), Gaps = 2/77 (2%)
Query: 11 LPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTG--EPVNSGHMIRSDLPRGWEEGFTEEG 68
LPE W DG+V++I+ R T+W+ PR +P+ I +LP GWEE + +
Sbjct: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQV 67
Query: 69 ASYFIDHNQQTTAFRHP 85
YFIDHN +TT P
Sbjct: 68 GDYFIDHNTKTTQIEDP 84
>gi|242247257 WW and C2 domain containing 1 isoform 2 [Homo
sapiens]
Length = 1118
Score = 63.9 bits (154), Expect = 8e-10
Identities = 30/77 (38%), Positives = 42/77 (54%), Gaps = 2/77 (2%)
Query: 11 LPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTG--EPVNSGHMIRSDLPRGWEEGFTEEG 68
LPE W DG+V++I+ R T+W+ PR +P+ I +LP GWEE + +
Sbjct: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQV 67
Query: 69 ASYFIDHNQQTTAFRHP 85
YFIDHN +TT P
Sbjct: 68 GDYFIDHNTKTTQIEDP 84
>gi|242247251 WW and C2 domain containing 1 isoform 1 [Homo
sapiens]
Length = 1119
Score = 63.9 bits (154), Expect = 8e-10
Identities = 30/77 (38%), Positives = 42/77 (54%), Gaps = 2/77 (2%)
Query: 11 LPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTG--EPVNSGHMIRSDLPRGWEEGFTEEG 68
LPE W DG+V++I+ R T+W+ PR +P+ I +LP GWEE + +
Sbjct: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQV 67
Query: 69 ASYFIDHNQQTTAFRHP 85
YFIDHN +TT P
Sbjct: 68 GDYFIDHNTKTTQIEDP 84
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 62.8 bits (151), Expect = 2e-09
Identities = 29/67 (43%), Positives = 38/67 (56%), Gaps = 5/67 (7%)
Query: 22 DGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRSDLPRGWEEGFTEEGASYFIDHNQQTTA 81
+GRV+++N R T W PRT G + LP GWE +T EG YF+DHN +TT
Sbjct: 417 NGRVYYVNHNTRTTQWEDPRT-----QGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTT 471
Query: 82 FRHPVTG 88
F+ P G
Sbjct: 472 FKDPRPG 478
Score = 53.5 bits (127), Expect = 1e-06
Identities = 26/85 (30%), Positives = 39/85 (45%), Gaps = 15/85 (17%)
Query: 1 MAAATVGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRSDLPRGW 60
+ AA D LP W +GRV++++ + TTW P LP GW
Sbjct: 292 LPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP---------------LPPGW 336
Query: 61 EEGFTEEGASYFIDHNQQTTAFRHP 85
E+ G Y++DHN +TT ++ P
Sbjct: 337 EKRTDPRGRFYYVDHNTRTTTWQRP 361
Score = 36.2 bits (82), Expect = 0.18
Identities = 13/31 (41%), Positives = 19/31 (61%)
Query: 56 LPRGWEEGFTEEGASYFIDHNQQTTAFRHPV 86
LP GWE+ G Y++DHN +TT + P+
Sbjct: 302 LPAGWEQRELPNGRVYYVDHNTKTTTWERPL 332
Score = 35.8 bits (81), Expect = 0.23
Identities = 24/107 (22%), Positives = 37/107 (34%), Gaps = 31/107 (28%)
Query: 11 LPEHWSYGVCRDGRVFFINDQLRCTTWLHPRT---------------------------- 42
LP W GR ++++ R TTW P
Sbjct: 332 LPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFL 391
Query: 43 --GEPVNSGHMIRSDLPRGWEEGFTEEGASYFIDHNQQTTAFRHPVT 87
++ H LP GWE+ + G Y+++HN +TT + P T
Sbjct: 392 YQSSSASTDHDPLGPLPPGWEKR-QDNGRVYYVNHNTRTTQWEDPRT 437
>gi|46852390 coiled-coil domain containing 6 [Homo sapiens]
Length = 474
Score = 62.4 bits (150), Expect = 2e-09
Identities = 76/339 (22%), Positives = 138/339 (40%), Gaps = 56/339 (16%)
Query: 657 LQLKKDLEYLDLKMTGRDLLKDRSLKPVKIAESDTDVKLSIFCEQDRVLQDLEDKIRALK 716
LQ +K+ ++ + L + S K +++ +++ + EQ+ + L KI+ L+
Sbjct: 123 LQKEKETLAVNYEKEEEFLTNELSRKLMQLQHEKAELEQHLEQEQEFQVNKLMKKIKKLE 182
Query: 717 ENKDQLESVLEVLHRQ---MEQYRDQPQH---------LEKIAYQQKLLQEDLVHIRA-- 762
+ + LE L R+ +E +Q Q ++K+ ++++LQE L +
Sbjct: 183 NDTISKQLTLEQLRREKIDLENTLEQEQEALVNRLWKRMDKLEAEKRILQEKLDQPVSAP 242
Query: 763 ----ELSRESTEMENAWNEYLKLENDVEQLKQTL----------------QEQHRRAFFF 802
++S E EN L+N+VE+LK+ L +E+H R
Sbjct: 243 PSPRDISMEIDSPENMMRHIRFLKNEVERLKKQLRAAQLQHSEKMAQYLEEERHMREENL 302
Query: 803 QEKSQIQKDLWRIEDVTAGLSANKENFRILVESVKNPERKTVPLFPHP---PVPSLSTSE 859
+ + ++Q+++ R E + LS ++ + + E N E L P P+P +
Sbjct: 303 RLQRKLQREMERREALCRQLSESESSLEMDDERYFN-EMSAQGLRPRTVSSPIPYTPSPS 361
Query: 860 SKPPPQP-----------SPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVTSPLQSP 908
S P P +PPTS R + P L H +T P SP
Sbjct: 362 SSRPISPGLSYASHTVGFTPPTSLTRAGMSYYNSPGLHVQ-----HMGTSHGITRP--SP 414
Query: 909 TKAKPKVEDEAPPRPPLPELYSPEDQPPAVPPLPREATI 947
++ + + P PP P +P PP PP P + T+
Sbjct: 415 RRSNSPDKFKRPTPPPSPNTQTPVQPPPPPPPPPMQPTV 453
>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
Length = 400
Score = 60.8 bits (146), Expect = 7e-09
Identities = 32/115 (27%), Positives = 56/115 (48%), Gaps = 1/115 (0%)
Query: 169 GWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRK 228
GWL K ++ WKRRWF+L D CL+Y++ + ++ G IPL + I V + R
Sbjct: 264 GWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREV-DDPRKPNC 322
Query: 229 YSFKAVHTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQV 283
+ + + + + A + + Y SA TQE+ + W++++ A V
Sbjct: 323 FELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSV 377
>gi|156546890 WW and C2 domain containing 2 [Homo sapiens]
Length = 1192
Score = 59.7 bits (143), Expect = 2e-08
Identities = 29/81 (35%), Positives = 43/81 (53%), Gaps = 2/81 (2%)
Query: 7 GRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTG--EPVNSGHMIRSDLPRGWEEGF 64
G+ LP W DG+VF+I+ R T+W+ PR +P++ + +LP GWE GF
Sbjct: 8 GQLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGF 67
Query: 65 TEEGASYFIDHNQQTTAFRHP 85
+ Y+IDH +TT P
Sbjct: 68 DPQIGVYYIDHINKTTQIEDP 88
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 58.5 bits (140), Expect = 3e-08
Identities = 34/104 (32%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 6 VGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIR------SDLPRG 59
V + LP W + +GR FFI+ + TTW PR PV+ LP G
Sbjct: 373 VTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPG 432
Query: 60 WEEGFTEEGASYFIDHNQQTTAFRHP------VTGQFSPENSEF 97
WEE +G +++IDHN + T + P +TG P + EF
Sbjct: 433 WEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREF 476
Score = 40.4 bits (93), Expect = 0.009
Identities = 23/70 (32%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
Query: 56 LPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQDRNQR 115
LP GWEE +G +Y+++HN +TT + P+ Q + + + N + Q R R
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM-QLAEDGASGSATNSNNHLIEPQIR--R 322
Query: 116 PSSMVSETST 125
P S+ S T T
Sbjct: 323 PRSLSSPTVT 332
Score = 39.3 bits (90), Expect = 0.021
Identities = 22/73 (30%), Positives = 32/73 (43%), Gaps = 1/73 (1%)
Query: 56 LPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQFSPENSEFILQ-EEPNPHMSKQDRNQ 114
LP GWEE G +Y+++HN +TT + P S E+ I Q + H + R
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH 133
Query: 115 RPSSMVSETSTAG 127
+ E S G
Sbjct: 134 ISEDLEPEPSEGG 146
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 58.5 bits (140), Expect = 3e-08
Identities = 34/104 (32%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 6 VGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIR------SDLPRG 59
V + LP W + +GR FFI+ + TTW PR PV+ LP G
Sbjct: 474 VTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPG 533
Query: 60 WEEGFTEEGASYFIDHNQQTTAFRHP------VTGQFSPENSEF 97
WEE +G +++IDHN + T + P +TG P + EF
Sbjct: 534 WEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREF 577
Score = 40.4 bits (93), Expect = 0.009
Identities = 23/70 (32%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
Query: 56 LPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQDRNQR 115
LP GWEE +G +Y+++HN +TT + P+ Q + + + N + Q R R
Sbjct: 367 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM-QLAEDGASGSATNSNNHLIEPQIR--R 423
Query: 116 PSSMVSETST 125
P S+ S T T
Sbjct: 424 PRSLSSPTVT 433
Score = 39.3 bits (90), Expect = 0.021
Identities = 22/73 (30%), Positives = 32/73 (43%), Gaps = 1/73 (1%)
Query: 56 LPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQFSPENSEFILQ-EEPNPHMSKQDRNQ 114
LP GWEE G +Y+++HN +TT + P S E+ I Q + H + R
Sbjct: 195 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH 254
Query: 115 RPSSMVSETSTAG 127
+ E S G
Sbjct: 255 ISEDLEPEPSEGG 267
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 58.5 bits (140), Expect = 3e-08
Identities = 34/104 (32%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 6 VGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIR------SDLPRG 59
V + LP W + +GR FFI+ + TTW PR PV+ LP G
Sbjct: 353 VTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPG 412
Query: 60 WEEGFTEEGASYFIDHNQQTTAFRHP------VTGQFSPENSEF 97
WEE +G +++IDHN + T + P +TG P + EF
Sbjct: 413 WEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREF 456
Score = 40.4 bits (93), Expect = 0.009
Identities = 23/70 (32%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
Query: 56 LPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQDRNQR 115
LP GWEE +G +Y+++HN +TT + P+ Q + + + N + Q R R
Sbjct: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM-QLAEDGASGSATNSNNHLIEPQIR--R 302
Query: 116 PSSMVSETST 125
P S+ S T T
Sbjct: 303 PRSLSSPTVT 312
Score = 39.3 bits (90), Expect = 0.021
Identities = 22/73 (30%), Positives = 32/73 (43%), Gaps = 1/73 (1%)
Query: 56 LPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQFSPENSEFILQ-EEPNPHMSKQDRNQ 114
LP GWEE G +Y+++HN +TT + P S E+ I Q + H + R
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH 133
Query: 115 RPSSMVSETSTAG 127
+ E S G
Sbjct: 134 ISEDLEPEPSEGG 146
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 58.5 bits (140), Expect = 3e-08
Identities = 34/104 (32%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 6 VGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIR------SDLPRG 59
V + LP W + +GR FFI+ + TTW PR PV+ LP G
Sbjct: 353 VTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPG 412
Query: 60 WEEGFTEEGASYFIDHNQQTTAFRHP------VTGQFSPENSEF 97
WEE +G +++IDHN + T + P +TG P + EF
Sbjct: 413 WEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREF 456
Score = 40.4 bits (93), Expect = 0.009
Identities = 23/70 (32%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
Query: 56 LPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQDRNQR 115
LP GWEE +G +Y+++HN +TT + P+ Q + + + N + Q R R
Sbjct: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM-QLAEDGASGSATNSNNHLIEPQIR--R 302
Query: 116 PSSMVSETST 125
P S+ S T T
Sbjct: 303 PRSLSSPTVT 312
Score = 39.3 bits (90), Expect = 0.021
Identities = 22/73 (30%), Positives = 32/73 (43%), Gaps = 1/73 (1%)
Query: 56 LPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQFSPENSEFILQ-EEPNPHMSKQDRNQ 114
LP GWEE G +Y+++HN +TT + P S E+ I Q + H + R
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH 133
Query: 115 RPSSMVSETSTAG 127
+ E S G
Sbjct: 134 ISEDLEPEPSEGG 146
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 58.5 bits (140), Expect = 3e-08
Identities = 34/104 (32%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 6 VGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIR------SDLPRG 59
V + LP W + +GR FFI+ + TTW PR PV+ LP G
Sbjct: 466 VTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPG 525
Query: 60 WEEGFTEEGASYFIDHNQQTTAFRHP------VTGQFSPENSEF 97
WEE +G +++IDHN + T + P +TG P + EF
Sbjct: 526 WEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREF 569
Score = 40.4 bits (93), Expect = 0.009
Identities = 23/70 (32%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
Query: 56 LPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQDRNQR 115
LP GWEE +G +Y+++HN +TT + P+ Q + + + N + Q R R
Sbjct: 359 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM-QLAEDGASGSATNSNNHLIEPQIR--R 415
Query: 116 PSSMVSETST 125
P S+ S T T
Sbjct: 416 PRSLSSPTVT 425
Score = 39.3 bits (90), Expect = 0.021
Identities = 22/73 (30%), Positives = 32/73 (43%), Gaps = 1/73 (1%)
Query: 56 LPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQFSPENSEFILQ-EEPNPHMSKQDRNQ 114
LP GWEE G +Y+++HN +TT + P S E+ I Q + H + R
Sbjct: 187 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH 246
Query: 115 RPSSMVSETSTAG 127
+ E S G
Sbjct: 247 ISEDLEPEPSEGG 259
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 58.5 bits (140), Expect = 3e-08
Identities = 34/104 (32%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 6 VGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIR------SDLPRG 59
V + LP W + +GR FFI+ + TTW PR PV+ LP G
Sbjct: 486 VTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPG 545
Query: 60 WEEGFTEEGASYFIDHNQQTTAFRHP------VTGQFSPENSEF 97
WEE +G +++IDHN + T + P +TG P + EF
Sbjct: 546 WEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREF 589
Score = 40.4 bits (93), Expect = 0.009
Identities = 23/70 (32%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
Query: 56 LPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQDRNQR 115
LP GWEE +G +Y+++HN +TT + P+ Q + + + N + Q R R
Sbjct: 379 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM-QLAEDGASGSATNSNNHLIEPQIR--R 435
Query: 116 PSSMVSETST 125
P S+ S T T
Sbjct: 436 PRSLSSPTVT 445
Score = 39.3 bits (90), Expect = 0.021
Identities = 22/73 (30%), Positives = 32/73 (43%), Gaps = 1/73 (1%)
Query: 56 LPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQFSPENSEFILQ-EEPNPHMSKQDRNQ 114
LP GWEE G +Y+++HN +TT + P S E+ I Q + H + R
Sbjct: 187 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH 246
Query: 115 RPSSMVSETSTAG 127
+ E S G
Sbjct: 247 ISEDLEPEPSEGG 259
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 58.5 bits (140), Expect = 3e-08
Identities = 34/104 (32%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 6 VGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIR------SDLPRG 59
V + LP W + +GR FFI+ + TTW PR PV+ LP G
Sbjct: 494 VTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPG 553
Query: 60 WEEGFTEEGASYFIDHNQQTTAFRHP------VTGQFSPENSEF 97
WEE +G +++IDHN + T + P +TG P + EF
Sbjct: 554 WEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREF 597
Score = 40.4 bits (93), Expect = 0.009
Identities = 23/70 (32%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
Query: 56 LPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQDRNQR 115
LP GWEE +G +Y+++HN +TT + P+ Q + + + N + Q R R
Sbjct: 387 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM-QLAEDGASGSATNSNNHLIEPQIR--R 443
Query: 116 PSSMVSETST 125
P S+ S T T
Sbjct: 444 PRSLSSPTVT 453
Score = 39.3 bits (90), Expect = 0.021
Identities = 22/73 (30%), Positives = 32/73 (43%), Gaps = 1/73 (1%)
Query: 56 LPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQFSPENSEFILQ-EEPNPHMSKQDRNQ 114
LP GWEE G +Y+++HN +TT + P S E+ I Q + H + R
Sbjct: 195 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH 254
Query: 115 RPSSMVSETSTAG 127
+ E S G
Sbjct: 255 ISEDLEPEPSEGG 267
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 58.5 bits (140), Expect = 3e-08
Identities = 34/104 (32%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 6 VGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIR------SDLPRG 59
V + LP W + +GR FFI+ + TTW PR PV+ LP G
Sbjct: 373 VTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPG 432
Query: 60 WEEGFTEEGASYFIDHNQQTTAFRHP------VTGQFSPENSEF 97
WEE +G +++IDHN + T + P +TG P + EF
Sbjct: 433 WEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREF 476
Score = 40.4 bits (93), Expect = 0.009
Identities = 23/70 (32%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
Query: 56 LPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQDRNQR 115
LP GWEE +G +Y+++HN +TT + P+ Q + + + N + Q R R
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM-QLAEDGASGSATNSNNHLIEPQIR--R 322
Query: 116 PSSMVSETST 125
P S+ S T T
Sbjct: 323 PRSLSSPTVT 332
Score = 39.3 bits (90), Expect = 0.021
Identities = 22/73 (30%), Positives = 32/73 (43%), Gaps = 1/73 (1%)
Query: 56 LPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQFSPENSEFILQ-EEPNPHMSKQDRNQ 114
LP GWEE G +Y+++HN +TT + P S E+ I Q + H + R
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH 133
Query: 115 RPSSMVSETSTAG 127
+ E S G
Sbjct: 134 ISEDLEPEPSEGG 146
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 58.5 bits (140), Expect = 3e-08
Identities = 34/104 (32%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 6 VGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIR------SDLPRG 59
V + LP W + +GR FFI+ + TTW PR PV+ LP G
Sbjct: 373 VTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPG 432
Query: 60 WEEGFTEEGASYFIDHNQQTTAFRHP------VTGQFSPENSEF 97
WEE +G +++IDHN + T + P +TG P + EF
Sbjct: 433 WEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREF 476
Score = 40.4 bits (93), Expect = 0.009
Identities = 23/70 (32%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
Query: 56 LPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQDRNQR 115
LP GWEE +G +Y+++HN +TT + P+ Q + + + N + Q R R
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM-QLAEDGASGSATNSNNHLIEPQIR--R 322
Query: 116 PSSMVSETST 125
P S+ S T T
Sbjct: 323 PRSLSSPTVT 332
Score = 39.3 bits (90), Expect = 0.021
Identities = 22/73 (30%), Positives = 32/73 (43%), Gaps = 1/73 (1%)
Query: 56 LPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQFSPENSEFILQ-EEPNPHMSKQDRNQ 114
LP GWEE G +Y+++HN +TT + P S E+ I Q + H + R
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH 133
Query: 115 RPSSMVSETSTAG 127
+ E S G
Sbjct: 134 ISEDLEPEPSEGG 146
>gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo
sapiens]
Length = 414
Score = 58.5 bits (140), Expect = 3e-08
Identities = 28/81 (34%), Positives = 39/81 (48%), Gaps = 4/81 (4%)
Query: 5 TVGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRSDLPRGWEEGF 64
T D LP W +DG V++ N T W HP+TG+ + DLP GWE+
Sbjct: 12 TDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGK----RKRVAGDLPYGWEQET 67
Query: 65 TEEGASYFIDHNQQTTAFRHP 85
E G +F+DH + T + P
Sbjct: 68 DENGQVFFVDHINKRTTYLDP 88
Score = 40.8 bits (94), Expect = 0.007
Identities = 15/35 (42%), Positives = 24/35 (68%)
Query: 55 DLPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQ 89
+LP GWEE T++G Y+ +H ++ T + HP TG+
Sbjct: 17 ELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGK 51
>gi|18860884 WW domain-containing oxidoreductase isoform 2 [Homo
sapiens]
Length = 189
Score = 58.5 bits (140), Expect = 3e-08
Identities = 28/81 (34%), Positives = 39/81 (48%), Gaps = 4/81 (4%)
Query: 5 TVGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRSDLPRGWEEGF 64
T D LP W +DG V++ N T W HP+TG+ + DLP GWE+
Sbjct: 12 TDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGK----RKRVAGDLPYGWEQET 67
Query: 65 TEEGASYFIDHNQQTTAFRHP 85
E G +F+DH + T + P
Sbjct: 68 DENGQVFFVDHINKRTTYLDP 88
Score = 40.8 bits (94), Expect = 0.007
Identities = 15/35 (42%), Positives = 24/35 (68%)
Query: 55 DLPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQ 89
+LP GWEE T++G Y+ +H ++ T + HP TG+
Sbjct: 17 ELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGK 51
>gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Homo
sapiens]
Length = 1034
Score = 58.5 bits (140), Expect = 3e-08
Identities = 36/130 (27%), Positives = 61/130 (46%), Gaps = 26/130 (20%)
Query: 169 GWLHKQDSSGM---RLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRI 225
GWL K+ + + WK+ WFVL D L++Y + +E G I LP + I +
Sbjct: 575 GWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRAS---EC 631
Query: 226 SRKYSFKAVHTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQ-AAQVL 284
+KY+FKA H ++++YF+A+ +DMN W+ +N A
Sbjct: 632 RKKYAFKACH-------------------PKIKSFYFAAEHLDDMNRWLNRINMLTAGYA 672
Query: 285 SRSSLKRDME 294
R +K++ +
Sbjct: 673 ERERIKQEQD 682
>gi|224451082 cytospin A [Homo sapiens]
Length = 1117
Score = 56.6 bits (135), Expect = 1e-07
Identities = 67/324 (20%), Positives = 130/324 (40%), Gaps = 36/324 (11%)
Query: 650 KSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPVKIAESDTDVKLSIFCEQDRVLQDLE 709
K +D + L+K LD K T R +K+ + E VKL + ++ DLE
Sbjct: 660 KQIEDLNMTLEKLRSDLDEKETERSDMKETIFELEDEVEQHRAVKL----HDNLIISDLE 715
Query: 710 DKIRALKENKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQKLLQEDL-VHIRAELSRES 768
+ ++ L++ K +E ++ LHR++ + + + + ++ D+ + E+
Sbjct: 716 NTVKKLQDQKHDMEREIKTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDLK 775
Query: 769 TEMENAWNEYLKLENDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVTAGLSANKEN 828
+ A + KL ++E++K QE+ R + + +++DL + GLS
Sbjct: 776 RRLHEAQEKNEKLTKELEEIKSRKQEE-ERGRVYNYMNAVERDLAALRQ-GMGLSRRSST 833
Query: 829 FRILVESVKNPERK--TVPLFPHPPVPSLSTSESKPPPQPSPPTSPVRTPLEVRLFPQLQ 886
+VK + + P+P ++ + P P +PP + V
Sbjct: 834 SSEPTPTVKTLIKSFDSASQVPNPAAAAIPRTPLSPSPMKTPPAAAV------------- 880
Query: 887 TYVPYRPHPPQLRKVTSPLQSPTKAKPKVEDEAPPRPPLPE----LYSPEDQPPAVPPLP 942
P Q ++ P+ S +K + D+ P +P L + PA LP
Sbjct: 881 -------SPMQRHSISGPI-STSKPLTALSDKRPNYGEIPVQEHLLRTSSASRPA--SLP 930
Query: 943 REATIIRHTSVRGLKRQSDERKRD 966
R + ++ +R S+E KRD
Sbjct: 931 RVPAMESAKTLSVSRRSSEEVKRD 954
Score = 37.0 bits (84), Expect = 0.10
Identities = 40/187 (21%), Positives = 81/187 (43%), Gaps = 23/187 (12%)
Query: 676 LKDRSLKPVKIAESDTDVKLSIFCEQDRVLQDLE------DKIRALKENKDQLESVLEVL 729
LK+RS +I ES+ K ++ + + ++++A EN+ Q + L +
Sbjct: 537 LKERSHHMERIIESEQKGKAALAATLEEYKATVASDQIEMNRLKAQLENEKQKVAELYSI 596
Query: 730 HRQ---------MEQYRDQPQHLEKIAYQQKLLQEDLVHIRAELSRESTEMENAWNEYLK 780
H +E R + E +A LQEDL H R + +R + +EY
Sbjct: 597 HNSGDKSDIQDLLESVRLDKEKAETLASS---LQEDLAHTRNDANRLQDAIAKVEDEYRA 653
Query: 781 LEND----VEQLKQTLQEQHRRAFFFQ-EKSQIQKDLWRIEDVTAGLSANKENFRILVES 835
+ + +E L TL++ + E+S +++ ++ +ED A K + +++
Sbjct: 654 FQEEAKKQIEDLNMTLEKLRSDLDEKETERSDMKETIFELEDEVEQHRAVKLHDNLIISD 713
Query: 836 VKNPERK 842
++N +K
Sbjct: 714 LENTVKK 720
>gi|224451080 cytospin A [Homo sapiens]
Length = 1117
Score = 56.6 bits (135), Expect = 1e-07
Identities = 67/324 (20%), Positives = 130/324 (40%), Gaps = 36/324 (11%)
Query: 650 KSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPVKIAESDTDVKLSIFCEQDRVLQDLE 709
K +D + L+K LD K T R +K+ + E VKL + ++ DLE
Sbjct: 660 KQIEDLNMTLEKLRSDLDEKETERSDMKETIFELEDEVEQHRAVKL----HDNLIISDLE 715
Query: 710 DKIRALKENKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQKLLQEDL-VHIRAELSRES 768
+ ++ L++ K +E ++ LHR++ + + + + ++ D+ + E+
Sbjct: 716 NTVKKLQDQKHDMEREIKTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDLK 775
Query: 769 TEMENAWNEYLKLENDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVTAGLSANKEN 828
+ A + KL ++E++K QE+ R + + +++DL + GLS
Sbjct: 776 RRLHEAQEKNEKLTKELEEIKSRKQEE-ERGRVYNYMNAVERDLAALRQ-GMGLSRRSST 833
Query: 829 FRILVESVKNPERK--TVPLFPHPPVPSLSTSESKPPPQPSPPTSPVRTPLEVRLFPQLQ 886
+VK + + P+P ++ + P P +PP + V
Sbjct: 834 SSEPTPTVKTLIKSFDSASQVPNPAAAAIPRTPLSPSPMKTPPAAAV------------- 880
Query: 887 TYVPYRPHPPQLRKVTSPLQSPTKAKPKVEDEAPPRPPLPE----LYSPEDQPPAVPPLP 942
P Q ++ P+ S +K + D+ P +P L + PA LP
Sbjct: 881 -------SPMQRHSISGPI-STSKPLTALSDKRPNYGEIPVQEHLLRTSSASRPA--SLP 930
Query: 943 REATIIRHTSVRGLKRQSDERKRD 966
R + ++ +R S+E KRD
Sbjct: 931 RVPAMESAKTLSVSRRSSEEVKRD 954
Score = 37.0 bits (84), Expect = 0.10
Identities = 40/187 (21%), Positives = 81/187 (43%), Gaps = 23/187 (12%)
Query: 676 LKDRSLKPVKIAESDTDVKLSIFCEQDRVLQDLE------DKIRALKENKDQLESVLEVL 729
LK+RS +I ES+ K ++ + + ++++A EN+ Q + L +
Sbjct: 537 LKERSHHMERIIESEQKGKAALAATLEEYKATVASDQIEMNRLKAQLENEKQKVAELYSI 596
Query: 730 HRQ---------MEQYRDQPQHLEKIAYQQKLLQEDLVHIRAELSRESTEMENAWNEYLK 780
H +E R + E +A LQEDL H R + +R + +EY
Sbjct: 597 HNSGDKSDIQDLLESVRLDKEKAETLASS---LQEDLAHTRNDANRLQDAIAKVEDEYRA 653
Query: 781 LEND----VEQLKQTLQEQHRRAFFFQ-EKSQIQKDLWRIEDVTAGLSANKENFRILVES 835
+ + +E L TL++ + E+S +++ ++ +ED A K + +++
Sbjct: 654 FQEEAKKQIEDLNMTLEKLRSDLDEKETERSDMKETIFELEDEVEQHRAVKLHDNLIISD 713
Query: 836 VKNPERK 842
++N +K
Sbjct: 714 LENTVKK 720
>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
sapiens]
Length = 748
Score = 56.6 bits (135), Expect = 1e-07
Identities = 37/111 (33%), Positives = 53/111 (47%), Gaps = 12/111 (10%)
Query: 169 GWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRK 228
GWL KQ ++ W RWFVL L+Y+KD E LG+I LP +S + K
Sbjct: 24 GWLRKQGGF-VKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVSEHPCNEENPGK 82
Query: 229 YSFKAVHTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQ 279
+ F+ V G R + TA + +Y A TQ DM WV+++ +
Sbjct: 83 FLFEVVPGGDR----DRMTANHE-------SYLLMASTQNDMEDWVKSIRR 122
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,321,419
Number of Sequences: 37866
Number of extensions: 3044121
Number of successful extensions: 29827
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 355
Number of HSP's successfully gapped in prelim test: 1305
Number of HSP's that attempted gapping in prelim test: 17077
Number of HSP's gapped (non-prelim): 10642
length of query: 1121
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1008
effective length of database: 13,968,660
effective search space: 14080409280
effective search space used: 14080409280
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.