Search of human proteins with 226246575

Search of human proteins with 226246575

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo
sapiens]
         (659 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo sapi...  1370   0.0  
gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]  1360   0.0  
gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo sapi...  1275   0.0  
gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo sapi...   758   0.0  
gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo sapi...   619   e-177
gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo sapi...   610   e-174
gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo sapi...   573   e-163
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi...   561   e-160
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi...   504   e-142
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg...   488   e-138
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu...   488   e-138
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul...   484   e-137
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]             465   e-131
gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]            465   e-131
gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]            465   e-131
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa...    86   1e-16
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom...    79   1e-14
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom...    79   1e-14
gi|40255197 RasGEF domain family, member 1C [Homo sapiens]             76   1e-13
gi|239582765 ral guanine nucleotide dissociation stimulator-like...    74   3e-13
gi|239582763 ral guanine nucleotide dissociation stimulator-like...    74   3e-13
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa...    73   1e-12
gi|224586880 Ras protein-specific guanine nucleotide-releasing f...    72   2e-12
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa...    72   2e-12
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa...    72   2e-12
gi|22749129 RasGEF domain family, member 1B [Homo sapiens]             72   2e-12
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo...    71   3e-12
gi|4758532 ral guanine nucleotide dissociation stimulator-like 2...    70   5e-12
gi|15529996 son of sevenless homolog 1 [Homo sapiens]                  70   6e-12
gi|110611226 UNC13 (C. elegans)-like [Homo sapiens]                    70   6e-12

>gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo
           sapiens]
          Length = 659

 Score = 1370 bits (3546), Expect = 0.0
 Identities = 659/659 (100%), Positives = 659/659 (100%)

Query: 1   MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
           MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1   MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60

Query: 61  LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
           LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61  LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120

Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLPGLGKKRKVS 180
           ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLPGLGKKRKVS
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLPGLGKKRKVS 180

Query: 181 LLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPALEGSVGLSNSVSRWV 240
           LLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPALEGSVGLSNSVSRWV
Sbjct: 181 LLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPALEGSVGLSNSVSRWV 240

Query: 241 QVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSP 300
           QVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSP
Sbjct: 241 QVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSP 300

Query: 301 DSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRL 360
           DSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRL
Sbjct: 301 DSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRL 360

Query: 361 HLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCP 420
           HLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCP
Sbjct: 361 HLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCP 420

Query: 421 KSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERL 480
           KSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERL
Sbjct: 421 KSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERL 480

Query: 481 SGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFC 540
           SGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFC
Sbjct: 481 SGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFC 540

Query: 541 DSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPH 600
           DSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPH
Sbjct: 541 DSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPH 600

Query: 601 ASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 659
           ASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS
Sbjct: 601 ASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 659


>gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]
          Length = 673

 Score = 1360 bits (3521), Expect = 0.0
 Identities = 659/673 (97%), Positives = 659/673 (97%), Gaps = 14/673 (2%)

Query: 1   MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
           MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1   MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60

Query: 61  LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
           LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61  LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120

Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDL---------- 170
           ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDL          
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180

Query: 171 ----PGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 226
               PGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240

Query: 227 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 286
           EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
Sbjct: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300

Query: 287 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS 346
           AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS
Sbjct: 301 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS 360

Query: 347 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED 406
           LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED
Sbjct: 361 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED 420

Query: 407 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP 466
           EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP
Sbjct: 421 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP 480

Query: 467 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL 526
           EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL
Sbjct: 481 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL 540

Query: 527 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA 586
           HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA
Sbjct: 541 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA 600

Query: 587 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV 646
           GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV
Sbjct: 601 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV 660

Query: 647 MDPPSTASSKLDS 659
           MDPPSTASSKLDS
Sbjct: 661 MDPPSTASSKLDS 673


>gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo
           sapiens]
          Length = 639

 Score = 1275 bits (3300), Expect = 0.0
 Identities = 625/673 (92%), Positives = 625/673 (92%), Gaps = 48/673 (7%)

Query: 1   MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
           MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1   MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60

Query: 61  LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
           LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61  LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120

Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDL---------- 170
           ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDL          
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180

Query: 171 ----PGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 226
               PGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT                   
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT------------------- 221

Query: 227 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 286
                          VMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
Sbjct: 222 ---------------VMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 266

Query: 287 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS 346
           AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS
Sbjct: 267 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS 326

Query: 347 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED 406
           LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED
Sbjct: 327 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED 386

Query: 407 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP 466
           EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP
Sbjct: 387 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP 446

Query: 467 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL 526
           EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL
Sbjct: 447 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL 506

Query: 527 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA 586
           HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA
Sbjct: 507 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA 566

Query: 587 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV 646
           GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV
Sbjct: 567 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV 626

Query: 647 MDPPSTASSKLDS 659
           MDPPSTASSKLDS
Sbjct: 627 MDPPSTASSKLDS 639


>gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo
           sapiens]
          Length = 576

 Score =  758 bits (1957), Expect = 0.0
 Identities = 355/355 (100%), Positives = 355/355 (100%)

Query: 305 ALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPK 364
           ALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPK
Sbjct: 222 ALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPK 281

Query: 365 LNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLP 424
           LNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLP
Sbjct: 282 LNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLP 341

Query: 425 PSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNF 484
           PSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNF
Sbjct: 342 PSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNF 401

Query: 485 PFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCS 544
           PFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCS
Sbjct: 402 PFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCS 461

Query: 545 GFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCG 604
           GFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCG
Sbjct: 462 GFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCG 521

Query: 605 SEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 659
           SEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS
Sbjct: 522 SEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 576



 Score =  414 bits (1065), Expect = e-115
 Identities = 207/221 (93%), Positives = 207/221 (93%), Gaps = 14/221 (6%)

Query: 1   MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
           MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1   MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60

Query: 61  LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
           LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61  LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120

Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDL---------- 170
           ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDL          
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180

Query: 171 ----PGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 207
               PGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 221


>gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo
           sapiens]
          Length = 604

 Score =  619 bits (1597), Expect = e-177
 Identities = 291/306 (95%), Positives = 293/306 (95%), Gaps = 5/306 (1%)

Query: 354 RLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSY 413
           RL D   HL   +      +ELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSY
Sbjct: 304 RLKDSHAHLSPDST-----KELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSY 358

Query: 414 AREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTIS 473
           AREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTIS
Sbjct: 359 AREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTIS 418

Query: 474 QEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVT 533
           QEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVT
Sbjct: 419 QEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVT 478

Query: 534 FRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPV 593
           FRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPV
Sbjct: 479 FRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPV 538

Query: 594 PSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTA 653
           PSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTA
Sbjct: 539 PSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTA 598

Query: 654 SSKLDS 659
           SSKLDS
Sbjct: 599 SSKLDS 604



 Score =  609 bits (1571), Expect = e-174
 Identities = 306/323 (94%), Positives = 307/323 (95%), Gaps = 14/323 (4%)

Query: 1   MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
           MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1   MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60

Query: 61  LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
           LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61  LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120

Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDL---------- 170
           ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDL          
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180

Query: 171 ----PGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 226
               PGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240

Query: 227 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 286
           EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
Sbjct: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300

Query: 287 AISRLKDSHAHLSPDSTKALLEL 309
           AISRLKDSHAHLSPDSTK L+ L
Sbjct: 301 AISRLKDSHAHLSPDSTKELVAL 323


>gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo
           sapiens]
          Length = 581

 Score =  610 bits (1573), Expect = e-174
 Identities = 312/340 (91%), Positives = 314/340 (92%), Gaps = 16/340 (4%)

Query: 1   MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
           MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1   MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60

Query: 61  LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
           LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61  LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120

Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDL---------- 170
           ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDL          
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180

Query: 171 ----PGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 226
               PGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240

Query: 227 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 286
           EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
Sbjct: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300

Query: 287 AISRLKDSHAHLSPDSTKALLEL--TELLASHNNYARYRR 324
           AISRLKDSHAHLSPDSTK  L+L  TE      +YAR  R
Sbjct: 301 AISRLKDSHAHLSPDSTKLSLDLFYTEDEIYELSYAREPR 340



 Score =  570 bits (1470), Expect = e-162
 Identities = 263/263 (100%), Positives = 263/263 (100%)

Query: 397 LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL 456
           LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL
Sbjct: 319 LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL 378

Query: 457 VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA 516
           VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA
Sbjct: 379 VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA 438

Query: 517 ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 576
           ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC
Sbjct: 439 ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 498

Query: 577 KKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPS 636
           KKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPS
Sbjct: 499 KKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPS 558

Query: 637 WETDTVPCPVMDPPSTASSKLDS 659
           WETDTVPCPVMDPPSTASSKLDS
Sbjct: 559 WETDTVPCPVMDPPSTASSKLDS 581


>gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo
           sapiens]
          Length = 484

 Score =  573 bits (1477), Expect = e-163
 Identities = 264/265 (99%), Positives = 265/265 (100%)

Query: 395 LTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE 454
           +TLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE
Sbjct: 220 ITLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE 279

Query: 455 QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA 514
           QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA
Sbjct: 280 QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA 339

Query: 515 SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV 574
           SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV
Sbjct: 340 SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV 399

Query: 575 ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH 634
           ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH
Sbjct: 400 ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH 459

Query: 635 PSWETDTVPCPVMDPPSTASSKLDS 659
           PSWETDTVPCPVMDPPSTASSKLDS
Sbjct: 460 PSWETDTVPCPVMDPPSTASSKLDS 484



 Score =  414 bits (1065), Expect = e-115
 Identities = 207/221 (93%), Positives = 207/221 (93%), Gaps = 14/221 (6%)

Query: 1   MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
           MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1   MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60

Query: 61  LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
           LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61  LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120

Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDL---------- 170
           ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDL          
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180

Query: 171 ----PGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 207
               PGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 221


>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
           sapiens]
          Length = 797

 Score =  561 bits (1447), Expect = e-160
 Identities = 285/569 (50%), Positives = 387/569 (68%), Gaps = 20/569 (3%)

Query: 34  PSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVL 93
           PS   I++    ++LG L++G  S D+L++ CIQSFD+ G+LC  + +L ++L MH  V+
Sbjct: 39  PSLAHITQFRMMVSLGHLAKGA-SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVI 97

Query: 94  PSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATV 153
            SA+L  +++T Y+ A         L+IC+ VRYW+     +   D  L + +  F   V
Sbjct: 98  SSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELV 157

Query: 154 AREGNSAQRRLGDSSDL--------------PGLGKKRKVSLLFDHLETGELAQHLTYLE 199
             +G     RL D++ +                  KKRKVSLLFDHLE  EL++HLTYLE
Sbjct: 158 KAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLE 217

Query: 200 FRSFQAITPQDLRSYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDK 259
           F+SF+ I+  D ++Y++   V+  P +E S+ L N +S+WVQ+MVLSRP P  RA+V  K
Sbjct: 218 FKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIK 277

Query: 260 FIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNY 319
           FI VAQ+LHQLQNFNTLMAV GGLCHS+ISRLK++ +H+  +  K L E+TELL+S  NY
Sbjct: 278 FIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNY 337

Query: 320 ARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQ 379
             YRR +  C  F++P+LGVHLKDL+SL+EA PD L DG++++ KL  LY  + ELV LQ
Sbjct: 338 DNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQ 397

Query: 380 GQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPG 439
              PP  AN+DL+HLLTLSLDL+YTEDEIYELSYAREPR  ++ P +P   P+VV+WA G
Sbjct: 398 EVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASG 457

Query: 440 VTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGR 499
           V+PKPD  T+ +HV+++V+SVFKNYD +  G ISQE+FE+++ +FPF+   +    +   
Sbjct: 458 VSPKPDPKTISKHVQRMVDSVFKNYDHDQDGYISQEEFEKIAASFPFSFCVM---DKDRE 514

Query: 500 GSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRE 559
           G  SR+E+T Y +RAS+I SKLGL F H F E T+ KPTFCD+C+GFLWGV KQGYRC++
Sbjct: 515 GLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKD 574

Query: 560 CGLCCHKHCRDQVKVECKKRPGAKGDAGP 588
           CG+ CHK C+D V  ECKKR  AK    P
Sbjct: 575 CGMNCHKQCKDLVVFECKKR--AKNPVAP 601


>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
           sapiens]
          Length = 762

 Score =  504 bits (1298), Expect = e-142
 Identities = 268/569 (47%), Positives = 358/569 (62%), Gaps = 55/569 (9%)

Query: 34  PSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVL 93
           PS   I++    ++LG L++G  S D+L++ CIQSFD+ G+LC  + +L ++L MH  V+
Sbjct: 39  PSLAHITQFRMMVSLGHLAKGA-SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVI 97

Query: 94  PSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATV 153
            SA+L  +++T Y+ A         L+IC+ VRYW+     +   D  L + +  F   V
Sbjct: 98  SSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELV 157

Query: 154 AREGNSAQRRLGDSSDL--------------PGLGKKRKVSLLFDHLETGELAQHLTYLE 199
             +G     RL D++ +                  KKRKVSLLFDHLE  EL++HLTYLE
Sbjct: 158 KAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLE 217

Query: 200 FRSFQAITPQDLRSYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDK 259
           F+SF+ I+  D ++Y++   V+  P +E S+ L N +S+WVQ+MVLSRP P  RA+V  K
Sbjct: 218 FKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIK 277

Query: 260 FIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNY 319
           FI VAQ+LHQLQNFNTLMAV GGLCHS+ISRLK++ +H+  +  K L E+TELL+S  NY
Sbjct: 278 FIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNY 337

Query: 320 ARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQ 379
             YRR +  C  F++P+LGVHLKDL+SL+EA PD L DG++++ KL  LY  + ELV LQ
Sbjct: 338 DNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQ 397

Query: 380 GQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPG 439
              PP  AN+DL+HLLTLSLDL+YTEDEIYELSYAREPR                     
Sbjct: 398 EVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPR--------------------- 436

Query: 440 VTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGR 499
                              SVFKNYD +  G ISQE+FE+++ +FPF+   +    +   
Sbjct: 437 --------------NHRAPSVFKNYDHDQDGYISQEEFEKIAASFPFSFCVM---DKDRE 479

Query: 500 GSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRE 559
           G  SR+E+T Y +RAS+I SKLGL F H F E T+ KPTFCD+C+GFLWGV KQGYRC++
Sbjct: 480 GLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKD 539

Query: 560 CGLCCHKHCRDQVKVECKKRPGAKGDAGP 588
           CG+ CHK C+D V  ECKKR  AK    P
Sbjct: 540 CGMNCHKQCKDLVVFECKKR--AKNPVAP 566


>gi|213385270 RAS guanyl releasing protein 3 (calcium and
           DAG-regulated) isoform 1 [Homo sapiens]
          Length = 690

 Score =  488 bits (1257), Expect = e-138
 Identities = 256/554 (46%), Positives = 359/554 (64%), Gaps = 22/554 (3%)

Query: 59  DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
           DELL  CI+ FD  G L    ++  +VL MH W L S +LA +LL  Y+ ATG++    R
Sbjct: 13  DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71

Query: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLPG------ 172
           L+IC+ +RYW+++ P   + D  L  +   F    ++ G      L D S +P       
Sbjct: 72  LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDWMRR 131

Query: 173 ------LGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 226
                 + KK K  LLFDHLE  ELA+HLT+LE +SF+ I+  D +SYV+ G +   P L
Sbjct: 132 VTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTL 191

Query: 227 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 286
           E S+ L N +S+WVQ+MVLS+P P QRA+V+ KFI+VA++L QL+NFNTLMAV GGL HS
Sbjct: 192 ERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHS 251

Query: 287 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS 346
           +ISRLK++H+HLS + TK   E+TEL++S+ NY  YR+ +A C GF++P+LGVHLKDL++
Sbjct: 252 SISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIA 311

Query: 347 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED 406
           +H   PD   + ++++ K++ L + L ELV+LQ        N DL++LLTLSLDL++TED
Sbjct: 312 VHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTED 371

Query: 407 EIYELSYAREPRCPKSLPPSPF--NAPLV-VEWAPGVTPKPDRVTLGRHVEQLVESVFKN 463
           +IY+LS   EPR  KS P SP   N P+V +EWA GV PKPD   + +H+ +LVESVF+N
Sbjct: 372 DIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVFRN 431

Query: 464 YDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA-SAICSKLG 522
           YD +  G ISQEDFE ++ NFPF         +   G  S++E+  Y LRA S +  K+G
Sbjct: 432 YDHDHDGYISQEDFESIAANFPF-LDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMG 490

Query: 523 LAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGA 582
             F+H F E+T+ KPTFC+ C+GFLWG+ KQGY+C++CG  CHK C+D + + C++   A
Sbjct: 491 PGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARA 550

Query: 583 ----KGDAGPPGAP 592
                G    PG+P
Sbjct: 551 PSLSSGHGSLPGSP 564


>gi|24762239 RAS guanyl releasing protein 3 (calcium and
           DAG-regulated) isoform 1 [Homo sapiens]
          Length = 690

 Score =  488 bits (1257), Expect = e-138
 Identities = 256/554 (46%), Positives = 359/554 (64%), Gaps = 22/554 (3%)

Query: 59  DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
           DELL  CI+ FD  G L    ++  +VL MH W L S +LA +LL  Y+ ATG++    R
Sbjct: 13  DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71

Query: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLPG------ 172
           L+IC+ +RYW+++ P   + D  L  +   F    ++ G      L D S +P       
Sbjct: 72  LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDWMRR 131

Query: 173 ------LGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 226
                 + KK K  LLFDHLE  ELA+HLT+LE +SF+ I+  D +SYV+ G +   P L
Sbjct: 132 VTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTL 191

Query: 227 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 286
           E S+ L N +S+WVQ+MVLS+P P QRA+V+ KFI+VA++L QL+NFNTLMAV GGL HS
Sbjct: 192 ERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHS 251

Query: 287 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS 346
           +ISRLK++H+HLS + TK   E+TEL++S+ NY  YR+ +A C GF++P+LGVHLKDL++
Sbjct: 252 SISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIA 311

Query: 347 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED 406
           +H   PD   + ++++ K++ L + L ELV+LQ        N DL++LLTLSLDL++TED
Sbjct: 312 VHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTED 371

Query: 407 EIYELSYAREPRCPKSLPPSPF--NAPLV-VEWAPGVTPKPDRVTLGRHVEQLVESVFKN 463
           +IY+LS   EPR  KS P SP   N P+V +EWA GV PKPD   + +H+ +LVESVF+N
Sbjct: 372 DIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVFRN 431

Query: 464 YDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA-SAICSKLG 522
           YD +  G ISQEDFE ++ NFPF         +   G  S++E+  Y LRA S +  K+G
Sbjct: 432 YDHDHDGYISQEDFESIAANFPF-LDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMG 490

Query: 523 LAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGA 582
             F+H F E+T+ KPTFC+ C+GFLWG+ KQGY+C++CG  CHK C+D + + C++   A
Sbjct: 491 PGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARA 550

Query: 583 ----KGDAGPPGAP 592
                G    PG+P
Sbjct: 551 PSLSSGHGSLPGSP 564


>gi|7662334 RAS guanyl releasing protein 3 (calcium and
           DAG-regulated) isoform 2 [Homo sapiens]
          Length = 689

 Score =  484 bits (1247), Expect = e-137
 Identities = 256/554 (46%), Positives = 359/554 (64%), Gaps = 23/554 (4%)

Query: 59  DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
           DELL  CI+ FD  G L    ++  +VL MH W L S +LA +LL  Y+ ATG++    R
Sbjct: 13  DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71

Query: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLPG------ 172
           L+IC+ +RYW+++ P   + D  L  +   F    ++ G      L D S +P       
Sbjct: 72  LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDWMRR 131

Query: 173 ------LGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 226
                 + KK K  LLFDHLE  ELA+HLT+LE +SF+ I+  D +SYV+ G +   P L
Sbjct: 132 VTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTL 191

Query: 227 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 286
           E S+ L N +S+WVQ+MVLS+P P QRA+V+ KFI+VA++L QL+NFNTLMAV GGL HS
Sbjct: 192 ERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHS 251

Query: 287 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS 346
           +ISRLK++H+HLS + TK   E+TEL++S+ NY  YR+ +A C GF++P+LGVHLKDL++
Sbjct: 252 SISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIA 311

Query: 347 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED 406
           +H   PD   + ++++ K++ L + L ELV+LQ        N DL++LLTLSLDL++TED
Sbjct: 312 VHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTED 371

Query: 407 EIYELSYAREPRCPKSLPPSPF--NAPLV-VEWAPGVTPKPDRVTLGRHVEQLVESVFKN 463
           +IY+LS   EPR  KS P SP   N P+V +EWA GV PKPD   + +H+ +LVESVF+N
Sbjct: 372 DIYKLSLVLEPRNSKS-PTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVFRN 430

Query: 464 YDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA-SAICSKLG 522
           YD +  G ISQEDFE ++ NFPF         +   G  S++E+  Y LRA S +  K+G
Sbjct: 431 YDHDHDGYISQEDFESIAANFPF-LDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMG 489

Query: 523 LAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGA 582
             F+H F E+T+ KPTFC+ C+GFLWG+ KQGY+C++CG  CHK C+D + + C++   A
Sbjct: 490 PGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARA 549

Query: 583 ----KGDAGPPGAP 592
                G    PG+P
Sbjct: 550 PSLSSGHGSLPGSP 563


>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
          Length = 609

 Score =  465 bits (1197), Expect = e-131
 Identities = 251/561 (44%), Positives = 340/561 (60%), Gaps = 25/561 (4%)

Query: 55  GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
           GC+ +ELL  CI++FD +G +  +  ++ M L MH W +PS+ LAA+LL  YQ++  D  
Sbjct: 10  GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68

Query: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLPGLG 174
              +++ CHLVRYW+   P     +P+L E I    A + +EGN     L D   +P   
Sbjct: 69  NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDIDSVPTYK 128

Query: 175 -------------KKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVR 221
                        KKRK+SLLFDHLE  ELA+HLTYLE+RSF  I  QD  S+V  G   
Sbjct: 129 WKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTV 188

Query: 222 GCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTG 281
             P LE  + L NSVS+WVQ+M+LS+P   QRA V+  F+HVA++L QLQNFNTLMAV G
Sbjct: 189 DNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVG 248

Query: 282 GLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHL 341
           GL HS+ISRLK++H+H+SP++ K    LTEL+ +  NY  YRR  A C GFR P+LGVHL
Sbjct: 249 GLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHL 308

Query: 342 KDLVSLHEAQPDRLPDGRLHL--PKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSL 399
           KDLV+L  A PD L   R  L   K+  L+  L+EL  +    PP  AN DLL LLT+SL
Sbjct: 309 KDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSL 368

Query: 400 DLFYTEDEIYELSYAREPRCPKSLPPSPFNA------PLVVEWAPGVTPKPDRVTLGRHV 453
           D + TEDE+Y+LS  REPR  KS P SP +       P++ EW     PK D+  +  H+
Sbjct: 369 DQYQTEDELYQLSLQREPR-SKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVVEHI 427

Query: 454 EQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLR 513
           E++VESVF+N+D +G G ISQE+F+ + GNFP+         +   G  SREE+  Y LR
Sbjct: 428 EKMVESVFRNFDVDGDGHISQEEFQIIRGNFPY-LSAFGDLDQNQDGCISREEMVSYFLR 486

Query: 514 ASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVK 573
           +S++     + F+H F E    +P  C  C   + G+ KQG +CR CG+ CHK C+D++ 
Sbjct: 487 SSSVLGG-RMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRLS 545

Query: 574 VECKKRPGAKGDAGPPGAPVP 594
           VEC++R  +    G   +P P
Sbjct: 546 VECRRRAQSVSLEGSAPSPSP 566


>gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
          Length = 609

 Score =  465 bits (1197), Expect = e-131
 Identities = 251/561 (44%), Positives = 340/561 (60%), Gaps = 25/561 (4%)

Query: 55  GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
           GC+ +ELL  CI++FD +G +  +  ++ M L MH W +PS+ LAA+LL  YQ++  D  
Sbjct: 10  GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68

Query: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLPGLG 174
              +++ CHLVRYW+   P     +P+L E I    A + +EGN     L D   +P   
Sbjct: 69  NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDIDSVPTYK 128

Query: 175 -------------KKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVR 221
                        KKRK+SLLFDHLE  ELA+HLTYLE+RSF  I  QD  S+V  G   
Sbjct: 129 WKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTV 188

Query: 222 GCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTG 281
             P LE  + L NSVS+WVQ+M+LS+P   QRA V+  F+HVA++L QLQNFNTLMAV G
Sbjct: 189 DNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVG 248

Query: 282 GLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHL 341
           GL HS+ISRLK++H+H+SP++ K    LTEL+ +  NY  YRR  A C GFR P+LGVHL
Sbjct: 249 GLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHL 308

Query: 342 KDLVSLHEAQPDRLPDGRLHL--PKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSL 399
           KDLV+L  A PD L   R  L   K+  L+  L+EL  +    PP  AN DLL LLT+SL
Sbjct: 309 KDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSL 368

Query: 400 DLFYTEDEIYELSYAREPRCPKSLPPSPFNA------PLVVEWAPGVTPKPDRVTLGRHV 453
           D + TEDE+Y+LS  REPR  KS P SP +       P++ EW     PK D+  +  H+
Sbjct: 369 DQYQTEDELYQLSLQREPR-SKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVVEHI 427

Query: 454 EQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLR 513
           E++VESVF+N+D +G G ISQE+F+ + GNFP+         +   G  SREE+  Y LR
Sbjct: 428 EKMVESVFRNFDVDGDGHISQEEFQIIRGNFPY-LSAFGDLDQNQDGCISREEMVSYFLR 486

Query: 514 ASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVK 573
           +S++     + F+H F E    +P  C  C   + G+ KQG +CR CG+ CHK C+D++ 
Sbjct: 487 SSSVLGG-RMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRLS 545

Query: 574 VECKKRPGAKGDAGPPGAPVP 594
           VEC++R  +    G   +P P
Sbjct: 546 VECRRRAQSVSLEGSAPSPSP 566


>gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]
          Length = 609

 Score =  465 bits (1197), Expect = e-131
 Identities = 251/561 (44%), Positives = 340/561 (60%), Gaps = 25/561 (4%)

Query: 55  GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
           GC+ +ELL  CI++FD +G +  +  ++ M L MH W +PS+ LAA+LL  YQ++  D  
Sbjct: 10  GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68

Query: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLPGLG 174
              +++ CHLVRYW+   P     +P+L E I    A + +EGN     L D   +P   
Sbjct: 69  NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDIDSVPTYK 128

Query: 175 -------------KKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVR 221
                        KKRK+SLLFDHLE  ELA+HLTYLE+RSF  I  QD  S+V  G   
Sbjct: 129 WKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTV 188

Query: 222 GCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTG 281
             P LE  + L NSVS+WVQ+M+LS+P   QRA V+  F+HVA++L QLQNFNTLMAV G
Sbjct: 189 DNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVG 248

Query: 282 GLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHL 341
           GL HS+ISRLK++H+H+SP++ K    LTEL+ +  NY  YRR  A C GFR P+LGVHL
Sbjct: 249 GLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHL 308

Query: 342 KDLVSLHEAQPDRLPDGRLHL--PKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSL 399
           KDLV+L  A PD L   R  L   K+  L+  L+EL  +    PP  AN DLL LLT+SL
Sbjct: 309 KDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSL 368

Query: 400 DLFYTEDEIYELSYAREPRCPKSLPPSPFNA------PLVVEWAPGVTPKPDRVTLGRHV 453
           D + TEDE+Y+LS  REPR  KS P SP +       P++ EW     PK D+  +  H+
Sbjct: 369 DQYQTEDELYQLSLQREPR-SKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVVEHI 427

Query: 454 EQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLR 513
           E++VESVF+N+D +G G ISQE+F+ + GNFP+         +   G  SREE+  Y LR
Sbjct: 428 EKMVESVFRNFDVDGDGHISQEEFQIIRGNFPY-LSAFGDLDQNQDGCISREEMVSYFLR 486

Query: 514 ASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVK 573
           +S++     + F+H F E    +P  C  C   + G+ KQG +CR CG+ CHK C+D++ 
Sbjct: 487 SSSVLGG-RMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRLS 545

Query: 574 VECKKRPGAKGDAGPPGAPVP 594
           VEC++R  +    G   +P P
Sbjct: 546 VECRRRAQSVSLEGSAPSPSP 566


>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
            2 [Homo sapiens]
          Length = 1237

 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 66/241 (27%), Positives = 114/241 (47%), Gaps = 5/241 (2%)

Query: 183  FDHLETGELAQHLTYLEFRSFQAITPQDL--RSYVLQGSVRGCPALEGSVGLSNSVSRWV 240
            F+ L   ELA+ +T L+   F++I  ++   + ++        P +  +    N +S  V
Sbjct: 998  FESLSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLV 1057

Query: 241  QVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSP 300
               +++      RA  ++K++ VA     L N+N ++ +T  L  SAI RLK + A +S 
Sbjct: 1058 ASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSK 1117

Query: 301  DSTKALLE-LTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGR 359
              TKAL++ L + ++S   +   R T   C    +P LG++L DL  + E  P+   +G 
Sbjct: 1118 Q-TKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGL 1176

Query: 360  LHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRC 419
            ++  K+  +   ++E+   Q           +   L L  DL   ED +YELS   EPR 
Sbjct: 1177 VNFSKMRMISHIIREIRQFQQTSYRIDHQPKVAQYL-LDKDLIIDEDTLYELSLKIEPRL 1235

Query: 420  P 420
            P
Sbjct: 1236 P 1236


>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
            sapiens]
          Length = 1095

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 63/252 (25%), Positives = 116/252 (46%), Gaps = 8/252 (3%)

Query: 167  SSDLPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 226
            S  L   G   +   L D   + E+A+ LT L+   F  I   ++  +  + +    P L
Sbjct: 839  SQPLAARGVAARPGTLHD-FHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNL 897

Query: 227  EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 286
                   N++S WV+ +++ +     R ++L KFI + + L +L NFN+ +A+   L  +
Sbjct: 898  TQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSA 957

Query: 287  AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS 346
             I RL+         +++ L E   L+ S +++  YR   +      +P LG+ L+DL  
Sbjct: 958  PIRRLE-----WQKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTF 1012

Query: 347  LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED 406
            +H   PD + DG+++  K    +  L  +   Q  H     N+D+++      D    E+
Sbjct: 1013 VHLGNPDYI-DGKVNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSD-HLAEE 1070

Query: 407  EIYELSYAREPR 418
             ++ELS   +PR
Sbjct: 1071 ALWELSLKIKPR 1082


>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
            sapiens]
          Length = 1077

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 63/252 (25%), Positives = 116/252 (46%), Gaps = 8/252 (3%)

Query: 167  SSDLPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 226
            S  L   G   +   L D   + E+A+ LT L+   F  I   ++  +  + +    P L
Sbjct: 821  SQPLAARGVAARPGTLHD-FHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNL 879

Query: 227  EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 286
                   N++S WV+ +++ +     R ++L KFI + + L +L NFN+ +A+   L  +
Sbjct: 880  TQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSA 939

Query: 287  AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS 346
             I RL+         +++ L E   L+ S +++  YR   +      +P LG+ L+DL  
Sbjct: 940  PIRRLE-----WQKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTF 994

Query: 347  LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED 406
            +H   PD + DG+++  K    +  L  +   Q  H     N+D+++      D    E+
Sbjct: 995  VHLGNPDYI-DGKVNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSD-HLAEE 1052

Query: 407  EIYELSYAREPR 418
             ++ELS   +PR
Sbjct: 1053 ALWELSLKIKPR 1064


>gi|40255197 RasGEF domain family, member 1C [Homo sapiens]
          Length = 466

 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 67/246 (27%), Positives = 111/246 (45%), Gaps = 25/246 (10%)

Query: 191 LAQHLTYLEFRSFQAITPQD-LRSYVLQ---GSVRGCPA-----LEGSVGLSNSVSRWVQ 241
           LAQ LT++E    + I P++ ++++V +    S + C +     LE  V   N +   V 
Sbjct: 204 LAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTSNLEAYVKWFNRLCYLVA 263

Query: 242 VMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPD 301
             +       QRAQV++ FI VA+    + NFN+LMA+  G+  S +SRLK + A +   
Sbjct: 264 TEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKV--- 320

Query: 302 STKALLELTELLASHNNYARYRRTWAGCAGFRL-----------PVLGVHLKDLVSLHEA 350
            T     L   +    N+  YR    G A   L           P   + +KD+  L+E 
Sbjct: 321 RTAKFFILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREKIVIPFFSLLIKDIYFLNEG 380

Query: 351 QPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYE 410
             +RLP+G ++  K   L  ++ E +  +    P   +  + H L  +    ++ED +Y 
Sbjct: 381 CANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDASITHYLYTA--PIFSEDGLYL 438

Query: 411 LSYARE 416
            SY  E
Sbjct: 439 ASYESE 444


>gi|239582765 ral guanine nucleotide dissociation stimulator-like 3
           isoform 1 [Homo sapiens]
          Length = 716

 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 71/263 (26%), Positives = 110/263 (41%), Gaps = 30/263 (11%)

Query: 190 ELAQHLTYLEFRSFQAITPQDLRSYVLQ-----GSVRGCPALEGSVGLSNSVSRWVQVMV 244
           E+A+ LT ++   F  +   +    V       G+    P +  +V   N+V+  V   V
Sbjct: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309

Query: 245 LSRPGPL--QRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDS 302
           L  PG    QRAQ L+K+I +AQR  +L+NF++L A+   L  + I RLK S   +S + 
Sbjct: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369

Query: 303 TKALLELTELLASHNNYARYRRTW---AGCAGFR-----------------LPVLGVHLK 342
                +L+++ +  NN+   R          G +                 +P LG  L 
Sbjct: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLT 429

Query: 343 DLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLF 402
           DLV L  A PD L    ++  K    +  L  +  LQ +    + +     L  L     
Sbjct: 430 DLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQ 489

Query: 403 YTEDEIYELSYAREP---RCPKS 422
            TE++ Y LS   EP    CP S
Sbjct: 490 LTEEQSYRLSRVIEPPAASCPSS 512


>gi|239582763 ral guanine nucleotide dissociation stimulator-like 3
           isoform 2 [Homo sapiens]
          Length = 710

 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 71/263 (26%), Positives = 110/263 (41%), Gaps = 30/263 (11%)

Query: 190 ELAQHLTYLEFRSFQAITPQDLRSYVLQ-----GSVRGCPALEGSVGLSNSVSRWVQVMV 244
           E+A+ LT ++   F  +   +    V       G+    P +  +V   N+V+  V   V
Sbjct: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309

Query: 245 LSRPGPL--QRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDS 302
           L  PG    QRAQ L+K+I +AQR  +L+NF++L A+   L  + I RLK S   +S + 
Sbjct: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369

Query: 303 TKALLELTELLASHNNYARYRRTW---AGCAGFR-----------------LPVLGVHLK 342
                +L+++ +  NN+   R          G +                 +P LG  L 
Sbjct: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLT 429

Query: 343 DLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLF 402
           DLV L  A PD L    ++  K    +  L  +  LQ +    + +     L  L     
Sbjct: 430 DLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQ 489

Query: 403 YTEDEIYELSYAREP---RCPKS 422
            TE++ Y LS   EP    CP S
Sbjct: 490 LTEEQSYRLSRVIEPPAASCPSS 512


>gi|54633319 PDZ domain-containing guanine nucleotide exchange factor
            I [Homo sapiens]
          Length = 1601

 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 56/226 (24%), Positives = 108/226 (47%), Gaps = 6/226 (2%)

Query: 156  EGNSAQRRLGDSSDLPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYV 215
            + N     L    D   L K+ ++S+L   L T E+A  L+  +F  F+ I P +    +
Sbjct: 831  KNNMETETLCSDEDAQELVKESQLSML--QLSTIEVATQLSMRDFDLFRNIEPTEYIDDL 888

Query: 216  LQ-GSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFN 274
             +  S  G   L+    + N  + WV   +L+    L+R +++  FI +A    + +NFN
Sbjct: 889  FKLNSKTGNTHLKRFEDIVNQETFWVASEILTEANQLKRMKIIKHFIKIALHCRECKNFN 948

Query: 275  TLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFR- 333
            ++ A+  GL  ++++RL+ +   L     K L +L ++     N A+YR   +  +    
Sbjct: 949  SMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPP 1008

Query: 334  -LPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVAL 378
             +P+  V  KD+  LHE    ++ DG ++  KL  +   ++++V +
Sbjct: 1009 IIPLFPVVKKDMTFLHEGNDSKV-DGLVNFEKLRMISKEIRQVVRM 1053


>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
            1 isoform 3 [Homo sapiens]
          Length = 1257

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 73/326 (22%), Positives = 138/326 (42%), Gaps = 31/326 (9%)

Query: 120  QICHLVRYWLMRHP------------------EVMHQDPQLEEVIGRFWATVAREGNSAQ 161
            ++ +++R+W+ +H                   EVMH DP+L     +  A + R     Q
Sbjct: 937  RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMH-DPELLTQERKAAANIIR--TLTQ 993

Query: 162  RRLGDSS----DLPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDL--RSYV 215
               GD+     ++  + +  K     +H    E+A+ LT L+   F+ I  ++   + ++
Sbjct: 994  EDPGDNQITLEEITQMAEGVKAEPFENHSAL-EIAEQLTLLDHLVFKKIPYEEFFGQGWM 1052

Query: 216  LQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNT 275
                    P +  +    N +S  +   ++       R   ++K++ VA     L N+N 
Sbjct: 1053 KLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNA 1112

Query: 276  LMAVTGGLCHSAISRLKDSHAHLSPDSTKALLE-LTELLASHNNYARYRRTWAGCAGFRL 334
            ++ +T  +  SAI RLK +   +S   TKAL++ L +L++S   +   R     C    +
Sbjct: 1113 VLEITSSMNRSAIFRLKKTWLKVSKQ-TKALIDKLQKLVSSEGRFKNLREALKNCDPPCV 1171

Query: 335  PVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHL 394
            P LG++L DL  + E  P+   DG ++  K+  +   ++E+   Q           +   
Sbjct: 1172 PYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQY 1231

Query: 395  LTLSLDLFYTEDEIYELSYAREPRCP 420
            L L       E+ +YE S   EP+ P
Sbjct: 1232 L-LDQSFVMDEESLYESSLRIEPKLP 1256


>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
            1 isoform 1 [Homo sapiens]
          Length = 1273

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 73/326 (22%), Positives = 138/326 (42%), Gaps = 31/326 (9%)

Query: 120  QICHLVRYWLMRHP------------------EVMHQDPQLEEVIGRFWATVAREGNSAQ 161
            ++ +++R+W+ +H                   EVMH DP+L     +  A + R     Q
Sbjct: 953  RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMH-DPELLTQERKAAANIIR--TLTQ 1009

Query: 162  RRLGDSS----DLPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDL--RSYV 215
               GD+     ++  + +  K     +H    E+A+ LT L+   F+ I  ++   + ++
Sbjct: 1010 EDPGDNQITLEEITQMAEGVKAEPFENHSAL-EIAEQLTLLDHLVFKKIPYEEFFGQGWM 1068

Query: 216  LQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNT 275
                    P +  +    N +S  +   ++       R   ++K++ VA     L N+N 
Sbjct: 1069 KLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNA 1128

Query: 276  LMAVTGGLCHSAISRLKDSHAHLSPDSTKALLE-LTELLASHNNYARYRRTWAGCAGFRL 334
            ++ +T  +  SAI RLK +   +S   TKAL++ L +L++S   +   R     C    +
Sbjct: 1129 VLEITSSMNRSAIFRLKKTWLKVSKQ-TKALIDKLQKLVSSEGRFKNLREALKNCDPPCV 1187

Query: 335  PVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHL 394
            P LG++L DL  + E  P+   DG ++  K+  +   ++E+   Q           +   
Sbjct: 1188 PYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQY 1247

Query: 395  LTLSLDLFYTEDEIYELSYAREPRCP 420
            L L       E+ +YE S   EP+ P
Sbjct: 1248 L-LDQSFVMDEESLYESSLRIEPKLP 1272


>gi|24797101 Ras protein-specific guanine nucleotide-releasing
           factor 1 isoform 2 [Homo sapiens]
          Length = 489

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 73/326 (22%), Positives = 138/326 (42%), Gaps = 31/326 (9%)

Query: 120 QICHLVRYWLMRHP------------------EVMHQDPQLEEVIGRFWATVAREGNSAQ 161
           ++ +++R+W+ +H                   EVMH DP+L     +  A + R     Q
Sbjct: 169 RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMH-DPELLTQERKAAANIIR--TLTQ 225

Query: 162 RRLGDSS----DLPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDL--RSYV 215
              GD+     ++  + +  K     +H    E+A+ LT L+   F+ I  ++   + ++
Sbjct: 226 EDPGDNQITLEEITQMAEGVKAEPFENHSAL-EIAEQLTLLDHLVFKKIPYEEFFGQGWM 284

Query: 216 LQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNT 275
                   P +  +    N +S  +   ++       R   ++K++ VA     L N+N 
Sbjct: 285 KLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNA 344

Query: 276 LMAVTGGLCHSAISRLKDSHAHLSPDSTKALLE-LTELLASHNNYARYRRTWAGCAGFRL 334
           ++ +T  +  SAI RLK +   +S   TKAL++ L +L++S   +   R     C    +
Sbjct: 345 VLEITSSMNRSAIFRLKKTWLKVSKQ-TKALIDKLQKLVSSEGRFKNLREALKNCDPPCV 403

Query: 335 PVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHL 394
           P LG++L DL  + E  P+   DG ++  K+  +   ++E+   Q           +   
Sbjct: 404 PYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQY 463

Query: 395 LTLSLDLFYTEDEIYELSYAREPRCP 420
           L L       E+ +YE S   EP+ P
Sbjct: 464 L-LDQSFVMDEESLYESSLRIEPKLP 488


>gi|22749129 RasGEF domain family, member 1B [Homo sapiens]
          Length = 473

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 66/249 (26%), Positives = 111/249 (44%), Gaps = 29/249 (11%)

Query: 191 LAQHLTYLEFRSFQAITPQDLRSYVLQ----GSVRGCPA-------LEGSVGLSNSVSRW 239
           LAQ LT++E      I P++     +Q     + + C +       LE  V   N +S  
Sbjct: 209 LAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYL 268

Query: 240 VQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLS 299
           V   +        RA++++ FI VA+    + NFN+LMA+  G+  S +SRLK + A + 
Sbjct: 269 VATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKV- 327

Query: 300 PDSTKALLELTELLASHNNYARYRRTWAGCAGFRL-----------PVLGVHLKDLVSLH 348
              T     L   +   +N+  YR    G A   L           P   + +KD+  L+
Sbjct: 328 --KTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLN 385

Query: 349 EAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLL-HLLTLSLDLFYTEDE 407
           E   +RLP+G ++  K   L  ++ E +  +    P   +  +L +LLT+ +   ++ED 
Sbjct: 386 EGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQYLLTVPV---FSEDA 442

Query: 408 IYELSYARE 416
           +Y  SY  E
Sbjct: 443 LYLASYESE 451


>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
           sapiens]
          Length = 583

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 83/306 (27%), Positives = 136/306 (44%), Gaps = 16/306 (5%)

Query: 151 ATVAREGNSAQRRLGDS-SDLPGLGKKRKVSLLFDHLETG--ELAQHLTYLEFRSFQAIT 207
           A  A E +S+   L D  S+L    KK   +++FD L+    E A  +T ++   F+AI 
Sbjct: 14  AATASEKSSSSESLSDKGSEL----KKSFDAVVFDVLKVTPEEYAGQITLMDVPVFKAIQ 69

Query: 208 PQDLRS--YVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQ 265
           P +L S  +  +      P         N VS WV   +L       RA+VL  +I  A+
Sbjct: 70  PDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVREILHAQTLKIRAEVLSHYIKTAK 129

Query: 266 RLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRT 325
           +L++L N + LMAV  GL  + I RL  + A LS        +L  +++  +NY R R  
Sbjct: 130 KLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKTTFEKLEYVMSKEDNYKRLRDY 189

Query: 326 WAGCAGFR-LPVLGVHLKDLVSLHEAQPD--RLPDGRLHLPKLNNLYLRLQEL-VALQGQ 381
            +       +P LG++L DL  +  A P    + +       +NN+   + +L  + +  
Sbjct: 190 ISSLKMTPCIPYLGIYLSDLTYIDSAYPSTGSILENEQRSNLMNNILRIISDLQQSCEYD 249

Query: 382 HPPCSANEDLLHLLTLSLDL-FYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGV 440
            P     +  L+ +    +L  + ED+ Y+LS   EP    S P S  +   +V    G 
Sbjct: 250 IPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIEP--GTSTPRSAASREDLVGPEVGA 307

Query: 441 TPKPDR 446
           +P+  R
Sbjct: 308 SPQSGR 313


>gi|4758532 ral guanine nucleotide dissociation stimulator-like 2
           [Homo sapiens]
          Length = 777

 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 65/230 (28%), Positives = 99/230 (43%), Gaps = 39/230 (16%)

Query: 191 LAQHLTYLEFRSFQAITPQDLRSYVL-----QGSVRGCPALEGSVGLSNSVSRWVQVMVL 245
           LA+ LT L+   F  + P      +       G    CP++  +V   N V+  V   VL
Sbjct: 247 LAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSVL 306

Query: 246 SR------PG--------PLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRL 291
                   PG        P QRA++L+K+I VA+    L+NF+++ AV   L  S I RL
Sbjct: 307 GATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRL 366

Query: 292 KDSHAHLSPDSTKALLELTELLASHNNYARYRRTW----------------AGCAGFR-- 333
           + +    + DS +    L ++ +  +NY++ R                   A  +G R  
Sbjct: 367 RAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGG 426

Query: 334 --LPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQ 381
             +P LG  LKDLV L  A  D L +G ++  K    +  L EL  LQ +
Sbjct: 427 GVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNE 476


>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
          Length = 1333

 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 83/332 (25%), Positives = 141/332 (42%), Gaps = 37/332 (11%)

Query: 190  ELAQHLTYLEFRSFQAITPQDLRSYVLQGSVR--GCPALEGSVGLSNSVSRWVQVMVLSR 247
            E+A+ LT LE   ++A+ P +L   V     +    P L   +  + +++ W +  ++  
Sbjct: 783  EIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVET 842

Query: 248  PGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALL 307
                +R  V+ + I + Q   +L NFN ++ V   +  S + RL  +   +     K L 
Sbjct: 843  ENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILE 902

Query: 308  ELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNN 367
            E  EL  S ++Y +Y           +P  G++L +++   E  P+ L   + H  +L N
Sbjct: 903  EAHEL--SEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVL---KRHGKELIN 957

Query: 368  LYLRLQ------ELVALQGQHPPCSANE-------DLLHLLTLSLDLFYTEDEIYELSYA 414
               R +      E+   Q Q P C   E       + L+ +  S++  +T D ++  S  
Sbjct: 958  FSKRRKVAEITGEIQQYQNQ-PYCLRVESDIKRFFENLNPMGNSMEKEFT-DYLFNKSLE 1015

Query: 415  REPRCPKSLP--PSPFNAPLVVEWAPGVTPKPDRVTLGRH---VEQLVESVFKNYDPEGR 469
             EPR PK LP  P  ++ PL    +PGV P   R    RH   ++Q    +  +  PE  
Sbjct: 1016 IEPRNPKPLPRFPKKYSYPLK---SPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPE-- 1070

Query: 470  GTISQEDFERLSGNFPFACHGLHPPPRQGRGS 501
               S+ +    + N P     L PPP  G  S
Sbjct: 1071 ---SETESTASAPNSPRT--PLTPPPASGASS 1097


>gi|110611226 UNC13 (C. elegans)-like [Homo sapiens]
          Length = 1591

 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 31/87 (35%), Positives = 46/87 (52%), Gaps = 2/87 (2%)

Query: 499 RGSFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYR 556
           R S   EEL  ++ + +  A+   +     H F   T   PT+C  C G LWG+ +QG R
Sbjct: 448 RTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMR 507

Query: 557 CRECGLCCHKHCRDQVKVECKKRPGAK 583
           C ECG+ CH+ C+D +  +C +R   K
Sbjct: 508 CSECGVKCHEKCQDLLNADCLQRAAEK 534


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,503,161
Number of Sequences: 37866
Number of extensions: 1578247
Number of successful extensions: 10135
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 128
Number of HSP's successfully gapped in prelim test: 66
Number of HSP's that attempted gapping in prelim test: 9023
Number of HSP's gapped (non-prelim): 1150
length of query: 659
length of database: 18,247,518
effective HSP length: 109
effective length of query: 550
effective length of database: 14,120,124
effective search space: 7766068200
effective search space used: 7766068200
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.