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Search of human proteins with 225579061
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|225579061 solute carrier family 12, member 4 isoform b [Homo
sapiens]
(1079 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|225579061 solute carrier family 12, member 4 isoform b [Homo ... 2170 0.0
gi|4827006 solute carrier family 12, member 4 isoform a [Homo sa... 2163 0.0
gi|225579065 solute carrier family 12, member 4 isoform d [Homo ... 2083 0.0
gi|225579067 solute carrier family 12, member 4 isoform e [Homo ... 2083 0.0
gi|225579063 solute carrier family 12, member 4 isoform c [Homo ... 2015 0.0
gi|4826780 solute carrier family 12, member 6 isoform b [Homo sa... 1657 0.0
gi|110224456 solute carrier family 12, member 6 isoform d [Homo ... 1652 0.0
gi|110224454 solute carrier family 12, member 6 isoform c [Homo ... 1652 0.0
gi|110224452 solute carrier family 12, member 6 isoform c [Homo ... 1652 0.0
gi|110224449 solute carrier family 12, member 6 isoform a [Homo ... 1652 0.0
gi|110224458 solute carrier family 12, member 6 isoform e [Homo ... 1649 0.0
gi|198041678 solute carrier family 12 (potassium-chloride transp... 1491 0.0
gi|123701900 solute carrier family 12 (potassium/chloride transp... 1489 0.0
gi|11968148 solute carrier family 12 (potassium-chloride transpo... 1489 0.0
gi|31881740 solute carrier family 12 (potassium/chloride transpo... 262 1e-69
gi|186910319 solute carrier family 12, member 3 isoform 3 [Homo ... 236 7e-62
gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo ... 233 7e-61
gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo ... 233 7e-61
gi|4506975 solute carrier family 12 (sodium/potassium/chloride t... 231 4e-60
gi|134254459 sodium potassium chloride cotransporter 2 [Homo sap... 212 1e-54
gi|38569457 solute carrier family 12, member 8 [Homo sapiens] 102 3e-21
gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo s... 51 7e-06
gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo s... 47 7e-05
gi|114326550 solute carrier family 7 (cationic amino acid transp... 39 0.020
gi|114326544 solute carrier family 7 (cationic amino acid transp... 39 0.020
gi|4507047 solute carrier family 7 (cationic amino acid transpor... 38 0.045
gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens] 37 0.077
gi|181337167 solute carrier family 7 (cationic amino acid transp... 36 0.17
gi|239748340 PREDICTED: hypothetical protein XP_002346633 [Homo ... 35 0.38
gi|187423910 solute carrier family 7, member 9 [Homo sapiens] 33 1.9
>gi|225579061 solute carrier family 12, member 4 isoform b [Homo
sapiens]
Length = 1079
Score = 2170 bits (5622), Expect = 0.0
Identities = 1079/1079 (100%), Positives = 1079/1079 (100%)
Query: 1 MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAELDDSDGHGNHRESSPFLSPLEASRGID 60
MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAELDDSDGHGNHRESSPFLSPLEASRGID
Sbjct: 1 MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAELDDSDGHGNHRESSPFLSPLEASRGID 60
Query: 61 YYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGT 120
YYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGT
Sbjct: 61 YYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGT 120
Query: 121 LMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVV 180
LMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVV
Sbjct: 121 LMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVV 180
Query: 181 PAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGA 240
PAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGA
Sbjct: 181 PAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGA 240
Query: 241 HDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIF 300
HDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIF
Sbjct: 241 HDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIF 300
Query: 301 DPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLN 360
DPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLN
Sbjct: 301 DPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLN 360
Query: 361 NVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSF 420
NVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSF
Sbjct: 361 NVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSF 420
Query: 421 TVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGV 480
TVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGV
Sbjct: 421 TVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGV 480
Query: 481 VLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIP 540
VLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIP
Sbjct: 481 VLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIP 540
Query: 541 FLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQT 600
FLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQT
Sbjct: 541 FLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQT 600
Query: 601 LLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKE 660
LLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKE
Sbjct: 601 LLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKE 660
Query: 661 WGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKA 720
WGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKA
Sbjct: 661 WGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKA 720
Query: 721 GKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQS 780
GKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQS
Sbjct: 721 GKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQS 780
Query: 781 CGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHER 840
CGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHER
Sbjct: 781 CGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHER 840
Query: 841 YLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLY 900
YLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLY
Sbjct: 841 YLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLY 900
Query: 901 HLRLEAEHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLY 960
HLRLEAEHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLY
Sbjct: 901 HLRLEAEHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLY 960
Query: 961 SDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLN 1020
SDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLN
Sbjct: 961 SDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLN 1020
Query: 1021 EVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1079
EVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS
Sbjct: 1021 EVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1079
>gi|4827006 solute carrier family 12, member 4 isoform a [Homo
sapiens]
Length = 1085
Score = 2163 bits (5605), Expect = 0.0
Identities = 1079/1085 (99%), Positives = 1079/1085 (99%), Gaps = 6/1085 (0%)
Query: 1 MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAELDDSDGHGNHRESSPFLSPLEASRGID 60
MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAELDDSDGHGNHRESSPFLSPLEASRGID
Sbjct: 1 MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAELDDSDGHGNHRESSPFLSPLEASRGID 60
Query: 61 YYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGT 120
YYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGT
Sbjct: 61 YYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGT 120
Query: 121 LMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVV 180
LMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVV
Sbjct: 121 LMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVV 180
Query: 181 PAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGA 240
PAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGA
Sbjct: 181 PAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGA 240
Query: 241 HDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIF 300
HDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIF
Sbjct: 241 HDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIF 300
Query: 301 DPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLN 360
DPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLN
Sbjct: 301 DPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLN 360
Query: 361 NVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSF 420
NVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSF
Sbjct: 361 NVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSF 420
Query: 421 TVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGV 480
TVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGV
Sbjct: 421 TVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGV 480
Query: 481 VLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIP 540
VLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIP
Sbjct: 481 VLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIP 540
Query: 541 FLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQT 600
FLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQT
Sbjct: 541 FLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQT 600
Query: 601 LLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKE 660
LLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKE
Sbjct: 601 LLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKE 660
Query: 661 WGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKA 720
WGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKA
Sbjct: 661 WGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKA 720
Query: 721 GKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQS 780
GKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQS
Sbjct: 721 GKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQS 780
Query: 781 CGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHER 840
CGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHER
Sbjct: 781 CGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHER 840
Query: 841 YLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLY 900
YLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLY
Sbjct: 841 YLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLY 900
Query: 901 HLRLEAE------HNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSAL 954
HLRLEAE HNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSAL
Sbjct: 901 HLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSAL 960
Query: 955 RLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMH 1014
RLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMH
Sbjct: 961 RLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMH 1020
Query: 1015 TAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREV 1074
TAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREV
Sbjct: 1021 TAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREV 1080
Query: 1075 ITIYS 1079
ITIYS
Sbjct: 1081 ITIYS 1085
>gi|225579065 solute carrier family 12, member 4 isoform d [Homo
sapiens]
Length = 1079
Score = 2083 bits (5398), Expect = 0.0
Identities = 1046/1067 (98%), Positives = 1048/1067 (98%), Gaps = 7/1067 (0%)
Query: 20 LEGLSWVDYGERAELDDSD-GHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPK 78
LEG +W + L GHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPK
Sbjct: 13 LEGTAWAVPEDTEPLASCTLGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPK 72
Query: 79 VSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILF 138
VSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILF
Sbjct: 73 VSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILF 132
Query: 139 LRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFG 198
LRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFG
Sbjct: 133 LRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFG 192
Query: 199 GAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIF 258
GAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIF
Sbjct: 193 GAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIF 252
Query: 259 LTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRD 318
LTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRD
Sbjct: 253 LTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRD 312
Query: 319 QFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQE 378
QFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQE
Sbjct: 313 QFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQE 372
Query: 379 NLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGS 438
NLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGS
Sbjct: 373 NLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGS 432
Query: 439 NRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGT 498
NRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGT
Sbjct: 433 NRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGT 492
Query: 499 LAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWAL 558
LAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWAL
Sbjct: 493 LAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWAL 552
Query: 559 LLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWAL 618
LLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWAL
Sbjct: 553 LLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWAL 612
Query: 619 SFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALL 678
SFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALL
Sbjct: 613 SFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALL 672
Query: 679 RLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLES 738
RLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLES
Sbjct: 673 RLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLES 732
Query: 739 YGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYG 798
YGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYG
Sbjct: 733 YGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYG 792
Query: 799 WRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGML 858
WRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGML
Sbjct: 793 WRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGML 852
Query: 859 MLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAE------HNSDI 912
MLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAE HNSDI
Sbjct: 853 MLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDI 912
Query: 913 SAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGAD 972
SAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGAD
Sbjct: 913 SAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGAD 972
Query: 973 KIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARL 1032
KIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARL
Sbjct: 973 KIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARL 1032
Query: 1033 VLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1079
VLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS
Sbjct: 1033 VLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1079
>gi|225579067 solute carrier family 12, member 4 isoform e [Homo
sapiens]
Length = 1054
Score = 2083 bits (5396), Expect = 0.0
Identities = 1042/1049 (99%), Positives = 1042/1049 (99%), Gaps = 6/1049 (0%)
Query: 37 SDGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGA 96
S GHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGA
Sbjct: 6 SPGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGA 65
Query: 97 KEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLI 156
KEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLI
Sbjct: 66 KEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLI 125
Query: 157 VLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMY 216
VLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMY
Sbjct: 126 VLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMY 185
Query: 217 ILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKF 276
ILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKF
Sbjct: 186 ILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKF 245
Query: 277 ASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVAT 336
ASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVAT
Sbjct: 246 ASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVAT 305
Query: 337 QLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGL 396
QLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGL
Sbjct: 306 QLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGL 365
Query: 397 PSADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTI 456
PSADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTI
Sbjct: 366 PSADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTI 425
Query: 457 LAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTC 516
LAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTC
Sbjct: 426 LAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTC 485
Query: 517 GAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDM 576
GAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDM
Sbjct: 486 GAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDM 545
Query: 577 VAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWY 636
VAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWY
Sbjct: 546 VAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWY 605
Query: 637 YALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLV 696
YALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLV
Sbjct: 606 YALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLV 665
Query: 697 LLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIE 756
LLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIE
Sbjct: 666 LLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIE 725
Query: 757 KVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVR 816
KVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVR
Sbjct: 726 KVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVR 785
Query: 817 CTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRM 876
CTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRM
Sbjct: 786 CTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRM 845
Query: 877 RIFTVAQMDDNSIQMKKDLAVFLYHLRLEAE------HNSDISAYTYERTLMMEQRSQML 930
RIFTVAQMDDNSIQMKKDLAVFLYHLRLEAE HNSDISAYTYERTLMMEQRSQML
Sbjct: 846 RIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQML 905
Query: 931 RQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDP 990
RQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDP
Sbjct: 906 RQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDP 965
Query: 991 SHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENY 1050
SHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENY
Sbjct: 966 SHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENY 1025
Query: 1051 MEFLEVLTEGLERVLLVRGGGREVITIYS 1079
MEFLEVLTEGLERVLLVRGGGREVITIYS
Sbjct: 1026 MEFLEVLTEGLERVLLVRGGGREVITIYS 1054
>gi|225579063 solute carrier family 12, member 4 isoform c [Homo
sapiens]
Length = 1087
Score = 2015 bits (5221), Expect = 0.0
Identities = 1009/1015 (99%), Positives = 1009/1015 (99%), Gaps = 6/1015 (0%)
Query: 71 EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ 130
EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ
Sbjct: 73 EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ 132
Query: 131 NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS 190
NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS
Sbjct: 133 NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS 192
Query: 191 RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN 250
RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN
Sbjct: 193 RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN 252
Query: 251 MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML 310
MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML
Sbjct: 253 MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML 312
Query: 311 GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG 370
GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG
Sbjct: 313 GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG 372
Query: 371 AAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPS 430
AAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPS
Sbjct: 373 AAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPS 432
Query: 431 VTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGV 490
VTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGV
Sbjct: 433 VTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGV 492
Query: 491 SRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKV 550
SRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKV
Sbjct: 493 SRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKV 552
Query: 551 NGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPR 610
NGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPR
Sbjct: 553 NGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPR 612
Query: 611 FKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSL 670
FKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSL
Sbjct: 613 FKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSL 672
Query: 671 SAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSV 730
SAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSV
Sbjct: 673 SAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSV 732
Query: 731 IQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNS 790
IQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNS
Sbjct: 733 IQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNS 792
Query: 791 VVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWW 850
VVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWW
Sbjct: 793 VVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWW 852
Query: 851 IVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAE--- 907
IVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAE
Sbjct: 853 IVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEV 912
Query: 908 ---HNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEE 964
HNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEE
Sbjct: 913 VEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEE 972
Query: 965 DESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIV 1024
DESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIV
Sbjct: 973 DESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIV 1032
Query: 1025 TRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1079
TRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS
Sbjct: 1033 TRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1087
>gi|4826780 solute carrier family 12, member 6 isoform b [Homo
sapiens]
Length = 1099
Score = 1657 bits (4291), Expect = 0.0
Identities = 832/1105 (75%), Positives = 938/1105 (84%), Gaps = 32/1105 (2%)
Query: 1 MPHFTVVPVDGPRRG-------------------DYDNLEGLSWVDYGERAELDDSDGHG 41
MPHFTV V+ P G D D + GE ++L D DGH
Sbjct: 1 MPHFTVTKVEDPEEGAAASISQEPSLADIKARIQDSDEPDLSQNSITGEHSQLLD-DGHK 59
Query: 42 NHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEE 101
R + +L+ G +Y+D+NLALFEEE+D RPKVSSLL ++ +YTNLTQGAKEHEE
Sbjct: 60 KARNA--YLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEE 117
Query: 102 AESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICC 161
AE+ +++ + P MGT MGVYLPCLQNIFGVILFLRLTW+VGTAGVLQA IVLICC
Sbjct: 118 AENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICC 177
Query: 162 CCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAI 221
CCT+LTAISMSAIATNGVVPAGGSYFMISR+LGPEFGGAVGLCFYLGTTFAAAMYILGAI
Sbjct: 178 CCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAI 237
Query: 222 EILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFL 281
EI L YI P AAIF+ A S A LNNMRVYGT FL M LVVF+GV+YVNKFASLFL
Sbjct: 238 EIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFL 297
Query: 282 ACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSF 341
ACVI+SIL+IYAG IKS F PP FPVCMLGNRTLS D+C+KT ++N TV ++LW F
Sbjct: 298 ACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGF 357
Query: 342 FCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADA 401
FC+S +CD YF+ NNVT I GIPG A+G++ ENLWS YL KG+I+EK PSA +
Sbjct: 358 FCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEK---PSAKS 414
Query: 402 PSLKESLPL-YVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAII 460
+ SL YV+ DI TSFT+LVGIFFPSVTGIMAGSNRSGDL+DAQKSIP+GTILAI+
Sbjct: 415 SDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAIL 474
Query: 461 TTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGL 520
TTS VY S+VVLFGACIEGVVLRDK+GD V NLVVGTL+WPSPWVIVIGSFFSTCGAGL
Sbjct: 475 TTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGL 534
Query: 521 QSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPI 580
QSLTGAPRLLQAIAKDNIIPFLRVFGH K NGEPTWALLLTA IAELGILIASLD+VAPI
Sbjct: 535 QSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPI 594
Query: 581 LSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALV 640
LSMFFLMCYLFVNLACA+QTLLRTPNWRPRF+YYHWALSF+GMS+CLALMF+SSWYYA+V
Sbjct: 595 LSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIV 654
Query: 641 AMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKL 700
AM+IAGMIYKYIEYQGAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHTKNWRPQLLVLLKL
Sbjct: 655 AMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKL 714
Query: 701 DEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKG 760
DEDLHVK+PRLLTFASQLKAGKGLTIVGSVI G+FLE+YGEA AAEQTIK++ME EKVKG
Sbjct: 715 DEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKG 774
Query: 761 FCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTA 820
FCQ+VVA+K+REG++HLIQSCGLGGM+HN+VV+GWP GWRQSED RAWKTFI TVR TTA
Sbjct: 775 FCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTA 834
Query: 821 AHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFT 880
AHLALLV KNI+F+PSN E++ EG+IDVWWIVHDGGMLMLLPFLL+QHKVWRKC +RIFT
Sbjct: 835 AHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFT 894
Query: 881 VAQMDDNSIQMKKDLAVFLYHLRLEAE------HNSDISAYTYERTLMMEQRSQMLRQMR 934
VAQ++DNSIQMKKDLA FLYHLR+EAE H+SDISAYTYERTLMMEQRSQMLR MR
Sbjct: 895 VAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMR 954
Query: 935 LTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAP 994
L+KTER+REAQLVKDR+S LRL S+ SDE++E+ +K+ MTWT+DKYM + +
Sbjct: 955 LSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSM 1014
Query: 995 DNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFL 1054
+ F++L++++PDQSNVRRMHTAVKLNEVIV +SH+A+LVLLNMPGPPRN EGDENYMEFL
Sbjct: 1015 EGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFL 1074
Query: 1055 EVLTEGLERVLLVRGGGREVITIYS 1079
EVLTEGLERVLLVRGGG EVITIYS
Sbjct: 1075 EVLTEGLERVLLVRGGGSEVITIYS 1099
>gi|110224456 solute carrier family 12, member 6 isoform d [Homo
sapiens]
Length = 1141
Score = 1652 bits (4277), Expect = 0.0
Identities = 821/1058 (77%), Positives = 925/1058 (87%), Gaps = 13/1058 (1%)
Query: 29 GERAELDDSDGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVS 88
GE ++L D DGH R + +L+ G +Y+D+NLALFEEE+D RPKVSSLL ++ +
Sbjct: 90 GEHSQLLD-DGHKKARNA--YLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMAN 146
Query: 89 YTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTA 148
YTNLTQGAKEHEEAE+ +++ + P MGT MGVYLPCLQNIFGVILFLRLTW+VGTA
Sbjct: 147 YTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTA 206
Query: 149 GVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLG 208
GVLQA IVLICCCCT+LTAISMSAIATNGVVPAGGSYFMISR+LGPEFGGAVGLCFYLG
Sbjct: 207 GVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLG 266
Query: 209 TTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFV 268
TTFAAAMYILGAIEI L YI P AAIF+ A S A LNNMRVYGT FL M LVVF+
Sbjct: 267 TTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFI 326
Query: 269 GVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAV 328
GV+YVNKFASLFLACVI+SIL+IYAG IKS F PP FPVCMLGNRTLS D+C+KT
Sbjct: 327 GVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKE 386
Query: 329 VDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKG 388
++N TV ++LW FFC+S +CD YF+ NNVT I GIPG A+G++ ENLWS YL KG
Sbjct: 387 INNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKG 446
Query: 389 DIVEKHGLPSADAPSLKESLPL-YVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDA 447
+I+EK PSA + + SL YV+ DI TSFT+LVGIFFPSVTGIMAGSNRSGDL+DA
Sbjct: 447 EIIEK---PSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDA 503
Query: 448 QKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVI 507
QKSIP+GTILAI+TTS VY S+VVLFGACIEGVVLRDK+GD V NLVVGTL+WPSPWVI
Sbjct: 504 QKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVI 563
Query: 508 VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAEL 567
VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGH K NGEPTWALLLTA IAEL
Sbjct: 564 VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAEL 623
Query: 568 GILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCL 627
GILIASLD+VAPILSMFFLMCYLFVNLACA+QTLLRTPNWRPRF+YYHWALSF+GMS+CL
Sbjct: 624 GILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICL 683
Query: 628 ALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHT 687
ALMF+SSWYYA+VAM+IAGMIYKYIEYQGAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHT
Sbjct: 684 ALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHT 743
Query: 688 KNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ 747
KNWRPQLLVLLKLDEDLHVK+PRLLTFASQLKAGKGLTIVGSVI G+FLE+YGEA AAEQ
Sbjct: 744 KNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQ 803
Query: 748 TIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRA 807
TIK++ME EKVKGFCQ+VVA+K+REG++HLIQSCGLGGM+HN+VV+GWP GWRQSED RA
Sbjct: 804 TIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARA 863
Query: 808 WKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQ 867
WKTFI TVR TTAAHLALLV KNI+F+PSN E++ EG+IDVWWIVHDGGMLMLLPFLL+Q
Sbjct: 864 WKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQ 923
Query: 868 HKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAE------HNSDISAYTYERTL 921
HKVWRKC +RIFTVAQ++DNSIQMKKDLA FLYHLR+EAE H+SDISAYTYERTL
Sbjct: 924 HKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTL 983
Query: 922 MMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRD 981
MMEQRSQMLR MRL+KTER+REAQLVKDR+S LRL S+ SDE++E+ +K+ MTWT+D
Sbjct: 984 MMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKD 1043
Query: 982 KYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPP 1041
KYM + + + F++L++++PDQSNVRRMHTAVKLNEVIV +SH+A+LVLLNMPGPP
Sbjct: 1044 KYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPP 1103
Query: 1042 RNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1079
RN EGDENYMEFLEVLTEGLERVLLVRGGG EVITIYS
Sbjct: 1104 RNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1141
>gi|110224454 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 1652 bits (4277), Expect = 0.0
Identities = 821/1058 (77%), Positives = 925/1058 (87%), Gaps = 13/1058 (1%)
Query: 29 GERAELDDSDGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVS 88
GE ++L D DGH R + +L+ G +Y+D+NLALFEEE+D RPKVSSLL ++ +
Sbjct: 40 GEHSQLLD-DGHKKARNA--YLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMAN 96
Query: 89 YTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTA 148
YTNLTQGAKEHEEAE+ +++ + P MGT MGVYLPCLQNIFGVILFLRLTW+VGTA
Sbjct: 97 YTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTA 156
Query: 149 GVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLG 208
GVLQA IVLICCCCT+LTAISMSAIATNGVVPAGGSYFMISR+LGPEFGGAVGLCFYLG
Sbjct: 157 GVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLG 216
Query: 209 TTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFV 268
TTFAAAMYILGAIEI L YI P AAIF+ A S A LNNMRVYGT FL M LVVF+
Sbjct: 217 TTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFI 276
Query: 269 GVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAV 328
GV+YVNKFASLFLACVI+SIL+IYAG IKS F PP FPVCMLGNRTLS D+C+KT
Sbjct: 277 GVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKE 336
Query: 329 VDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKG 388
++N TV ++LW FFC+S +CD YF+ NNVT I GIPG A+G++ ENLWS YL KG
Sbjct: 337 INNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKG 396
Query: 389 DIVEKHGLPSADAPSLKESLPL-YVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDA 447
+I+EK PSA + + SL YV+ DI TSFT+LVGIFFPSVTGIMAGSNRSGDL+DA
Sbjct: 397 EIIEK---PSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDA 453
Query: 448 QKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVI 507
QKSIP+GTILAI+TTS VY S+VVLFGACIEGVVLRDK+GD V NLVVGTL+WPSPWVI
Sbjct: 454 QKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVI 513
Query: 508 VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAEL 567
VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGH K NGEPTWALLLTA IAEL
Sbjct: 514 VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAEL 573
Query: 568 GILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCL 627
GILIASLD+VAPILSMFFLMCYLFVNLACA+QTLLRTPNWRPRF+YYHWALSF+GMS+CL
Sbjct: 574 GILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICL 633
Query: 628 ALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHT 687
ALMF+SSWYYA+VAM+IAGMIYKYIEYQGAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHT
Sbjct: 634 ALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHT 693
Query: 688 KNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ 747
KNWRPQLLVLLKLDEDLHVK+PRLLTFASQLKAGKGLTIVGSVI G+FLE+YGEA AAEQ
Sbjct: 694 KNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQ 753
Query: 748 TIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRA 807
TIK++ME EKVKGFCQ+VVA+K+REG++HLIQSCGLGGM+HN+VV+GWP GWRQSED RA
Sbjct: 754 TIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARA 813
Query: 808 WKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQ 867
WKTFI TVR TTAAHLALLV KNI+F+PSN E++ EG+IDVWWIVHDGGMLMLLPFLL+Q
Sbjct: 814 WKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQ 873
Query: 868 HKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAE------HNSDISAYTYERTL 921
HKVWRKC +RIFTVAQ++DNSIQMKKDLA FLYHLR+EAE H+SDISAYTYERTL
Sbjct: 874 HKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTL 933
Query: 922 MMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRD 981
MMEQRSQMLR MRL+KTER+REAQLVKDR+S LRL S+ SDE++E+ +K+ MTWT+D
Sbjct: 934 MMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKD 993
Query: 982 KYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPP 1041
KYM + + + F++L++++PDQSNVRRMHTAVKLNEVIV +SH+A+LVLLNMPGPP
Sbjct: 994 KYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPP 1053
Query: 1042 RNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1079
RN EGDENYMEFLEVLTEGLERVLLVRGGG EVITIYS
Sbjct: 1054 RNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1091
>gi|110224452 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 1652 bits (4277), Expect = 0.0
Identities = 821/1058 (77%), Positives = 925/1058 (87%), Gaps = 13/1058 (1%)
Query: 29 GERAELDDSDGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVS 88
GE ++L D DGH R + +L+ G +Y+D+NLALFEEE+D RPKVSSLL ++ +
Sbjct: 40 GEHSQLLD-DGHKKARNA--YLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMAN 96
Query: 89 YTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTA 148
YTNLTQGAKEHEEAE+ +++ + P MGT MGVYLPCLQNIFGVILFLRLTW+VGTA
Sbjct: 97 YTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTA 156
Query: 149 GVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLG 208
GVLQA IVLICCCCT+LTAISMSAIATNGVVPAGGSYFMISR+LGPEFGGAVGLCFYLG
Sbjct: 157 GVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLG 216
Query: 209 TTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFV 268
TTFAAAMYILGAIEI L YI P AAIF+ A S A LNNMRVYGT FL M LVVF+
Sbjct: 217 TTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFI 276
Query: 269 GVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAV 328
GV+YVNKFASLFLACVI+SIL+IYAG IKS F PP FPVCMLGNRTLS D+C+KT
Sbjct: 277 GVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKE 336
Query: 329 VDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKG 388
++N TV ++LW FFC+S +CD YF+ NNVT I GIPG A+G++ ENLWS YL KG
Sbjct: 337 INNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKG 396
Query: 389 DIVEKHGLPSADAPSLKESLPL-YVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDA 447
+I+EK PSA + + SL YV+ DI TSFT+LVGIFFPSVTGIMAGSNRSGDL+DA
Sbjct: 397 EIIEK---PSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDA 453
Query: 448 QKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVI 507
QKSIP+GTILAI+TTS VY S+VVLFGACIEGVVLRDK+GD V NLVVGTL+WPSPWVI
Sbjct: 454 QKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVI 513
Query: 508 VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAEL 567
VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGH K NGEPTWALLLTA IAEL
Sbjct: 514 VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAEL 573
Query: 568 GILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCL 627
GILIASLD+VAPILSMFFLMCYLFVNLACA+QTLLRTPNWRPRF+YYHWALSF+GMS+CL
Sbjct: 574 GILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICL 633
Query: 628 ALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHT 687
ALMF+SSWYYA+VAM+IAGMIYKYIEYQGAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHT
Sbjct: 634 ALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHT 693
Query: 688 KNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ 747
KNWRPQLLVLLKLDEDLHVK+PRLLTFASQLKAGKGLTIVGSVI G+FLE+YGEA AAEQ
Sbjct: 694 KNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQ 753
Query: 748 TIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRA 807
TIK++ME EKVKGFCQ+VVA+K+REG++HLIQSCGLGGM+HN+VV+GWP GWRQSED RA
Sbjct: 754 TIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARA 813
Query: 808 WKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQ 867
WKTFI TVR TTAAHLALLV KNI+F+PSN E++ EG+IDVWWIVHDGGMLMLLPFLL+Q
Sbjct: 814 WKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQ 873
Query: 868 HKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAE------HNSDISAYTYERTL 921
HKVWRKC +RIFTVAQ++DNSIQMKKDLA FLYHLR+EAE H+SDISAYTYERTL
Sbjct: 874 HKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTL 933
Query: 922 MMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRD 981
MMEQRSQMLR MRL+KTER+REAQLVKDR+S LRL S+ SDE++E+ +K+ MTWT+D
Sbjct: 934 MMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKD 993
Query: 982 KYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPP 1041
KYM + + + F++L++++PDQSNVRRMHTAVKLNEVIV +SH+A+LVLLNMPGPP
Sbjct: 994 KYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPP 1053
Query: 1042 RNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1079
RN EGDENYMEFLEVLTEGLERVLLVRGGG EVITIYS
Sbjct: 1054 RNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1091
>gi|110224449 solute carrier family 12, member 6 isoform a [Homo
sapiens]
Length = 1150
Score = 1652 bits (4277), Expect = 0.0
Identities = 821/1058 (77%), Positives = 925/1058 (87%), Gaps = 13/1058 (1%)
Query: 29 GERAELDDSDGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVS 88
GE ++L D DGH R + +L+ G +Y+D+NLALFEEE+D RPKVSSLL ++ +
Sbjct: 99 GEHSQLLD-DGHKKARNA--YLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMAN 155
Query: 89 YTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTA 148
YTNLTQGAKEHEEAE+ +++ + P MGT MGVYLPCLQNIFGVILFLRLTW+VGTA
Sbjct: 156 YTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTA 215
Query: 149 GVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLG 208
GVLQA IVLICCCCT+LTAISMSAIATNGVVPAGGSYFMISR+LGPEFGGAVGLCFYLG
Sbjct: 216 GVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLG 275
Query: 209 TTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFV 268
TTFAAAMYILGAIEI L YI P AAIF+ A S A LNNMRVYGT FL M LVVF+
Sbjct: 276 TTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFI 335
Query: 269 GVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAV 328
GV+YVNKFASLFLACVI+SIL+IYAG IKS F PP FPVCMLGNRTLS D+C+KT
Sbjct: 336 GVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKE 395
Query: 329 VDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKG 388
++N TV ++LW FFC+S +CD YF+ NNVT I GIPG A+G++ ENLWS YL KG
Sbjct: 396 INNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKG 455
Query: 389 DIVEKHGLPSADAPSLKESLPL-YVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDA 447
+I+EK PSA + + SL YV+ DI TSFT+LVGIFFPSVTGIMAGSNRSGDL+DA
Sbjct: 456 EIIEK---PSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDA 512
Query: 448 QKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVI 507
QKSIP+GTILAI+TTS VY S+VVLFGACIEGVVLRDK+GD V NLVVGTL+WPSPWVI
Sbjct: 513 QKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVI 572
Query: 508 VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAEL 567
VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGH K NGEPTWALLLTA IAEL
Sbjct: 573 VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAEL 632
Query: 568 GILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCL 627
GILIASLD+VAPILSMFFLMCYLFVNLACA+QTLLRTPNWRPRF+YYHWALSF+GMS+CL
Sbjct: 633 GILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICL 692
Query: 628 ALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHT 687
ALMF+SSWYYA+VAM+IAGMIYKYIEYQGAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHT
Sbjct: 693 ALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHT 752
Query: 688 KNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ 747
KNWRPQLLVLLKLDEDLHVK+PRLLTFASQLKAGKGLTIVGSVI G+FLE+YGEA AAEQ
Sbjct: 753 KNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQ 812
Query: 748 TIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRA 807
TIK++ME EKVKGFCQ+VVA+K+REG++HLIQSCGLGGM+HN+VV+GWP GWRQSED RA
Sbjct: 813 TIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARA 872
Query: 808 WKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQ 867
WKTFI TVR TTAAHLALLV KNI+F+PSN E++ EG+IDVWWIVHDGGMLMLLPFLL+Q
Sbjct: 873 WKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQ 932
Query: 868 HKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAE------HNSDISAYTYERTL 921
HKVWRKC +RIFTVAQ++DNSIQMKKDLA FLYHLR+EAE H+SDISAYTYERTL
Sbjct: 933 HKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTL 992
Query: 922 MMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRD 981
MMEQRSQMLR MRL+KTER+REAQLVKDR+S LRL S+ SDE++E+ +K+ MTWT+D
Sbjct: 993 MMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKD 1052
Query: 982 KYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPP 1041
KYM + + + F++L++++PDQSNVRRMHTAVKLNEVIV +SH+A+LVLLNMPGPP
Sbjct: 1053 KYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPP 1112
Query: 1042 RNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1079
RN EGDENYMEFLEVLTEGLERVLLVRGGG EVITIYS
Sbjct: 1113 RNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1150
>gi|110224458 solute carrier family 12, member 6 isoform e [Homo
sapiens]
Length = 1135
Score = 1649 bits (4271), Expect = 0.0
Identities = 817/1051 (77%), Positives = 920/1051 (87%), Gaps = 12/1051 (1%)
Query: 36 DSDGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQG 95
+ DGH R + +L+ G +Y+D+NLALFEEE+D RPKVSSLL ++ +YTNLTQG
Sbjct: 90 EDDGHKKARNA--YLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQG 147
Query: 96 AKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALL 155
AKEHEEAE+ +++ + P MGT MGVYLPCLQNIFGVILFLRLTW+VGTAGVLQA
Sbjct: 148 AKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFA 207
Query: 156 IVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAM 215
IVLICCCCT+LTAISMSAIATNGVVPAGGSYFMISR+LGPEFGGAVGLCFYLGTTFAAAM
Sbjct: 208 IVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAM 267
Query: 216 YILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNK 275
YILGAIEI L YI P AAIF+ A S A LNNMRVYGT FL M LVVF+GV+YVNK
Sbjct: 268 YILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNK 327
Query: 276 FASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVA 335
FASLFLACVI+SIL+IYAG IKS F PP FPVCMLGNRTLS D+C+KT ++N TV
Sbjct: 328 FASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVP 387
Query: 336 TQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHG 395
++LW FFC+S +CD YF+ NNVT I GIPG A+G++ ENLWS YL KG+I+EK
Sbjct: 388 SKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEK-- 445
Query: 396 LPSADAPSLKESLPL-YVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVG 454
PSA + + SL YV+ DI TSFT+LVGIFFPSVTGIMAGSNRSGDL+DAQKSIP+G
Sbjct: 446 -PSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIG 504
Query: 455 TILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFS 514
TILAI+TTS VY S+VVLFGACIEGVVLRDK+GD V NLVVGTL+WPSPWVIVIGSFFS
Sbjct: 505 TILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFS 564
Query: 515 TCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASL 574
TCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGH K NGEPTWALLLTA IAELGILIASL
Sbjct: 565 TCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASL 624
Query: 575 DMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSS 634
D+VAPILSMFFLMCYLFVNLACA+QTLLRTPNWRPRF+YYHWALSF+GMS+CLALMF+SS
Sbjct: 625 DLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISS 684
Query: 635 WYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQL 694
WYYA+VAM+IAGMIYKYIEYQGAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHTKNWRPQL
Sbjct: 685 WYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQL 744
Query: 695 LVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMME 754
LVLLKLDEDLHVK+PRLLTFASQLKAGKGLTIVGSVI G+FLE+YGEA AAEQTIK++ME
Sbjct: 745 LVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLME 804
Query: 755 IEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDT 814
EKVKGFCQ+VVA+K+REG++HLIQSCGLGGM+HN+VV+GWP GWRQSED RAWKTFI T
Sbjct: 805 AEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGT 864
Query: 815 VRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKC 874
VR TTAAHLALLV KNI+F+PSN E++ EG+IDVWWIVHDGGMLMLLPFLL+QHKVWRKC
Sbjct: 865 VRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKC 924
Query: 875 RMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAE------HNSDISAYTYERTLMMEQRSQ 928
+RIFTVAQ++DNSIQMKKDLA FLYHLR+EAE H+SDISAYTYERTLMMEQRSQ
Sbjct: 925 SIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQ 984
Query: 929 MLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETW 988
MLR MRL+KTER+REAQLVKDR+S LRL S+ SDE++E+ +K+ MTWT+DKYM
Sbjct: 985 MLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRG 1044
Query: 989 DPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDE 1048
+ + + F++L++++PDQSNVRRMHTAVKLNEVIV +SH+A+LVLLNMPGPPRN EGDE
Sbjct: 1045 QKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDE 1104
Query: 1049 NYMEFLEVLTEGLERVLLVRGGGREVITIYS 1079
NYMEFLEVLTEGLERVLLVRGGG EVITIYS
Sbjct: 1105 NYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1135
>gi|198041678 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 1 [Homo sapiens]
Length = 1139
Score = 1491 bits (3859), Expect = 0.0
Identities = 755/1105 (68%), Positives = 879/1105 (79%), Gaps = 62/1105 (5%)
Query: 35 DDSDGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQ 94
+D G GN +ESSPF++ + +G +Y +N+ALFEEE+D P VSSLL L +YTNL Q
Sbjct: 37 EDVKGDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQ 96
Query: 95 GAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQAL 154
G++EHEEAE+ EG +++ +AP MGT MGVYLPCLQNIFGVILFLRLTW+VG AG++++
Sbjct: 97 GSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESF 156
Query: 155 LIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAA 214
+V ICC CT+LTAISMSAIATNGVVPAGGSY+MISRSLGPEFGGAVGLCFYLGTTFA A
Sbjct: 157 CMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGA 216
Query: 215 MYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVN 274
MYILG IEILL Y+ P AIF A + A LNNMRVYGT LT M VVFVGVKYVN
Sbjct: 217 MYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVN 276
Query: 275 KFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETV 334
KFA +FL CVI+SIL+IYAG IKS FDPP FP+C+LGNRTLSR FD+CAK A NETV
Sbjct: 277 KFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETV 336
Query: 335 ATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKH 394
T+LW FC S L +CD YF NNVTEI GIPGAA+G+++ENLWS+YL KG IVE+
Sbjct: 337 TTRLWGLFCSSRFLNA-TCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERS 395
Query: 395 GLPS---ADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSI 451
G+ S AD + P YV +D+ + FT+LVGI+FPSVTGIMAGSNRSGDLRDAQKSI
Sbjct: 396 GMTSVGLADGTPIDMDHP-YVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSI 454
Query: 452 PVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGS 511
P GTILAI TTS VY SSVVLFGACIEGVVLRDK+G+ V+ NLVVGTLAWPSPWVIVIGS
Sbjct: 455 PTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGS 514
Query: 512 FFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILI 571
FFSTCGAGLQSLTGAPRLLQAI++D I+PFL+VFGHGK NGEPTWALLLTA I E+GILI
Sbjct: 515 FFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILI 574
Query: 572 ASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMF 631
ASLD VAPILSMFFLMCY+FVNLACAVQTLLRTPNWRPRF+YYHW LSFLGMSLCLALMF
Sbjct: 575 ASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMF 634
Query: 632 VSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWR 691
+ SWYYALVAMLIAG+IYKYIEY+GAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWR
Sbjct: 635 ICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWR 694
Query: 692 PQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKN 751
PQLLVL+++D+D +V +P+LL+ SQLKAGKGLTIVGSV++G+FLE++ +AQ AE++I+
Sbjct: 695 PQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRR 754
Query: 752 MMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTF 811
+ME EKVKGFCQVV++S +R+G++HLIQS GLGG++HN+V++GWP WRQ ED + W+ F
Sbjct: 755 LMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNF 814
Query: 812 IDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVW 871
I+ VR TTA HLALLV KN++ +P N ER+ EG IDVWWIVHDGGMLMLLPFLLR HKVW
Sbjct: 815 IELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVW 874
Query: 872 RKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAE------HNSDISAYTYERTLMMEQ 925
RKC+MRIFTVAQMDDNSIQMKKDL FLYHLR+ AE H SDISAYTYE+TL+MEQ
Sbjct: 875 RKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQ 934
Query: 926 RSQMLRQMRLTKTEREREAQLVKDR-----------HSALRL---ESLYSDEED------ 965
RSQ+L+QM LTK ERERE Q + D ++ LRL E D E+
Sbjct: 935 RSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEV 994
Query: 966 ------------------------ESAVGADKIQMTWTRDKYMTE-TWDPSH-APDNFRE 999
E +K+ +TWT+DK + E PS + + ++
Sbjct: 995 QLIHDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKD 1054
Query: 1000 LVHIKPD-----QSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFL 1054
+KP+ QSNVRRMHTAV+LNEVIV +S DA+LVLLNMPGPPRN GDENYMEFL
Sbjct: 1055 FFSMKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFL 1114
Query: 1055 EVLTEGLERVLLVRGGGREVITIYS 1079
EVLTE L+RV+LVRGGGREVITIYS
Sbjct: 1115 EVLTEHLDRVMLVRGGGREVITIYS 1139
>gi|123701900 solute carrier family 12 (potassium/chloride
transporters), member 7 [Homo sapiens]
Length = 1083
Score = 1489 bits (3856), Expect = 0.0
Identities = 752/1088 (69%), Positives = 874/1088 (80%), Gaps = 19/1088 (1%)
Query: 3 HFTVVPVDGPRRGDYDNL-EGLSWVDYGERAELD-DSDGHGNHRESSPFLSPLEASRGID 60
+FTVVPV+ G D E E E + S G GN RE+SPFL+ +E +
Sbjct: 4 NFTVVPVEAHADGGGDETAERTEAPGTPEGPEPERPSPGDGNPRENSPFLNNVEVEQESF 63
Query: 61 YYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGT 120
+ +N+ALFEEE+D P VSSLL KL +YTNL+QG EHEE E +RRR A+AP MGT
Sbjct: 64 FEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEDEE---SRRREAKAPRMGT 120
Query: 121 LMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVV 180
+GVYLPCLQNI GVILFLRLTW+VG AGVL++ LIV +CC CT+LTAISMSAIATNGVV
Sbjct: 121 FIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIATNGVV 180
Query: 181 PAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGA 240
PAGGSY+MISRSLGPEFGGAVGLCFYLGTTFA AMYILG IEI LTYI+P AAIF A
Sbjct: 181 PAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIFQAEAA 240
Query: 241 HDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIF 300
+ A L+NMRVYGT L M LVVFVGVKYVNK A +FLACV++SIL+IYAG IKS F
Sbjct: 241 GGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKSAF 300
Query: 301 DPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLN 360
DPP PVC+LGNRTLSR FD C K + N + + LW FC+ + +CD YF+ N
Sbjct: 301 DPPDIPVCLLGNRTLSRRSFDACVKAYGIHNNSATSALWGLFCNGSQPSA-ACDEYFIQN 359
Query: 361 NVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAP--SLKESLPLYVVADIAT 418
NVTEI GIPGAA+GV ENLWS Y G VEK G+PS S +LP YV+ DIA
Sbjct: 360 NVTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGVPSVPVAEESRASALP-YVLTDIAA 418
Query: 419 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIE 478
SFT+LVGI+FPSVTGIMAGSNRSGDL+DAQKSIP GTILAI+TTS +Y S +VLFGACIE
Sbjct: 419 SFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIE 478
Query: 479 GVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNI 538
GVVLRDK+G+ + NLV+G LAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIA+D I
Sbjct: 479 GVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGI 538
Query: 539 IPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAV 598
+PFL+VFGHGK NGEPTWALLLT LI E GILIASLD VAPILSMFFLMCYLFVNLACAV
Sbjct: 539 VPFLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLFVNLACAV 598
Query: 599 QTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAE 658
QTLLRTPNWRPRFK+YHW LSFLGMSLCLALMF+ SWYYAL AMLIAG IYKYIEY+GAE
Sbjct: 599 QTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAE 658
Query: 659 KEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQL 718
KEWGDGIRGLSL+AARYALLR+E GPPHTKNWRPQ+LV+L LD + VK+PRLL+F SQL
Sbjct: 659 KEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQL 718
Query: 719 KAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLI 778
KAGKGLTIVGSV++G++L+ + EAQ AE+ I+++M EK KGFCQ+VV+S +R+G++HLI
Sbjct: 719 KAGKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLI 778
Query: 779 QSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNH 838
QS GLGG++HN+V++ WP W+Q ++P +WK F+DTVR TTAAH ALLV KN+ +P N
Sbjct: 779 QSAGLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQNQ 838
Query: 839 ERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVF 898
ER+ GHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQ+DDNSIQMKKDL +F
Sbjct: 839 ERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMF 898
Query: 899 LYHLRLEAE------HNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHS 952
LYHLR+ AE +DISA+TYERTLMMEQRSQML+QM+L+K E+EREAQL+ DR++
Sbjct: 899 LYHLRISAEVEVVEMVENDISAFTYERTLMMEQRSQMLKQMQLSKNEQEREAQLIHDRNT 958
Query: 953 ALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETW-DPSHAPDNFRELVHIKPDQSNVR 1011
A + ++ DK+QMTWTR+K + E + + F++L +KPDQSNVR
Sbjct: 959 ASHTAAA---ARTQAPPTPDKVQMTWTREKLIAEKYRSRDTSLSGFKDLFSMKPDQSNVR 1015
Query: 1012 RMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGG 1071
RMHTAVKLN V++ +S DA+LVLLNMPGPP+N +GDENYMEFLEVLTEGL RVLLVRGGG
Sbjct: 1016 RMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGG 1075
Query: 1072 REVITIYS 1079
REVITIYS
Sbjct: 1076 REVITIYS 1083
>gi|11968148 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 2 [Homo sapiens]
Length = 1116
Score = 1489 bits (3854), Expect = 0.0
Identities = 754/1101 (68%), Positives = 877/1101 (79%), Gaps = 62/1101 (5%)
Query: 39 GHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKE 98
G GN +ESSPF++ + +G +Y +N+ALFEEE+D P VSSLL L +YTNL QG++E
Sbjct: 18 GDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSRE 77
Query: 99 HEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVL 158
HEEAE+ EG +++ +AP MGT MGVYLPCLQNIFGVILFLRLTW+VG AG++++ +V
Sbjct: 78 HEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVF 137
Query: 159 ICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYIL 218
ICC CT+LTAISMSAIATNGVVPAGGSY+MISRSLGPEFGGAVGLCFYLGTTFA AMYIL
Sbjct: 138 ICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYIL 197
Query: 219 GAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFAS 278
G IEILL Y+ P AIF A + A LNNMRVYGT LT M VVFVGVKYVNKFA
Sbjct: 198 GTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFAL 257
Query: 279 LFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQL 338
+FL CVI+SIL+IYAG IKS FDPP FP+C+LGNRTLSR FD+CAK A NETV T+L
Sbjct: 258 VFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRL 317
Query: 339 WSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPS 398
W FC S L +CD YF NNVTEI GIPGAA+G+++ENLWS+YL KG IVE+ G+ S
Sbjct: 318 WGLFCSSRFLNA-TCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTS 376
Query: 399 ---ADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGT 455
AD + P YV +D+ + FT+LVGI+FPSVTGIMAGSNRSGDLRDAQKSIP GT
Sbjct: 377 VGLADGTPIDMDHP-YVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGT 435
Query: 456 ILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFST 515
ILAI TTS VY SSVVLFGACIEGVVLRDK+G+ V+ NLVVGTLAWPSPWVIVIGSFFST
Sbjct: 436 ILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFST 495
Query: 516 CGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLD 575
CGAGLQSLTGAPRLLQAI++D I+PFL+VFGHGK NGEPTWALLLTA I E+GILIASLD
Sbjct: 496 CGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLD 555
Query: 576 MVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSW 635
VAPILSMFFLMCY+FVNLACAVQTLLRTPNWRPRF+YYHW LSFLGMSLCLALMF+ SW
Sbjct: 556 EVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSW 615
Query: 636 YYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLL 695
YYALVAMLIAG+IYKYIEY+GAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLL
Sbjct: 616 YYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLL 675
Query: 696 VLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEI 755
VL+++D+D +V +P+LL+ SQLKAGKGLTIVGSV++G+FLE++ +AQ AE++I+ +ME
Sbjct: 676 VLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEA 735
Query: 756 EKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTV 815
EKVKGFCQVV++S +R+G++HLIQS GLGG++HN+V++GWP WRQ ED + W+ FI+ V
Sbjct: 736 EKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELV 795
Query: 816 RCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCR 875
R TTA HLALLV KN++ +P N ER+ EG IDVWWIVHDGGMLMLLPFLLR HKVWRKC+
Sbjct: 796 RETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCK 855
Query: 876 MRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAE------HNSDISAYTYERTLMMEQRSQM 929
MRIFTVAQMDDNSIQMKKDL FLYHLR+ AE H SDISAYTYE+TL+MEQRSQ+
Sbjct: 856 MRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQI 915
Query: 930 LRQMRLTKTEREREAQLVKDR-----------HSALRL---ESLYSDEED---------- 965
L+QM LTK ERERE Q + D ++ LRL E D E+
Sbjct: 916 LKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIH 975
Query: 966 --------------------ESAVGADKIQMTWTRDKYMTE-TWDPSH-APDNFRELVHI 1003
E +K+ +TWT+DK + E PS + + ++ +
Sbjct: 976 DQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSM 1035
Query: 1004 KPD-----QSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLT 1058
KP+ QSNVRRMHTAV+LNEVIV +S DA+LVLLNMPGPPRN GDENYMEFLEVLT
Sbjct: 1036 KPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLT 1095
Query: 1059 EGLERVLLVRGGGREVITIYS 1079
E L+RV+LVRGGGREVITIYS
Sbjct: 1096 EHLDRVMLVRGGGREVITIYS 1116
>gi|31881740 solute carrier family 12 (potassium/chloride
transporters), member 9 [Homo sapiens]
Length = 914
Score = 262 bits (670), Expect = 1e-69
Identities = 217/697 (31%), Positives = 338/697 (48%), Gaps = 111/697 (15%)
Query: 113 AEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMS 172
A A + T +GV +P + ++F +++FLR+ ++VG AG+LQAL ++L+ LT +S+
Sbjct: 32 ASARKLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVC 91
Query: 173 AIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPA 232
AIATNG V GG+YFMISR+LGPE GG++GL FYL + G LL +
Sbjct: 92 AIATNGAVQGGGAYFMISRTLGPEVGGSIGLMFYLAN-------VCGCAVSLLGLVESVL 144
Query: 233 AIFYPSGAHDTSNATLNNM-RVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSI 291
+F GA T + L + + YG L + SL L V
Sbjct: 145 DVF---GADATGPSGLRVLPQGYGWNLL----------------YGSLLLGLV------- 178
Query: 292 YAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTD 351
GG VC LG +R F T ++ + ++A+ L SF P
Sbjct: 179 --GG-----------VCTLGAGLYARASF----LTFLLVSGSLASVLISFVAVGPRDIRL 221
Query: 352 SCDPYFMLNNVTEIPG----IPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKES 407
+ P N + +P G + L++NL + Y E
Sbjct: 222 TPRPG---PNGSSLPPRFGHFTGFNSSTLKDNLGAGYAE--------------------D 258
Query: 408 LPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYF 467
V + A+ F VL F TGIMAG+N SG+L+D ++IP+GTI+A+ T VY
Sbjct: 259 YTTGAVMNFASVFAVL----FNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYV 314
Query: 468 SSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAP 527
L + +L++ YG + +L WP +++IG + + A + SL GA
Sbjct: 315 LLFFLSSFTCDRTLLQEDYGFFRAISL------WPP--LVLIGIYATALSASMSSLIGAS 366
Query: 528 RLLQAIAKDNIIPFLRVFGHGKV---NGEPTWALLLTALIAELGILIASLDMVAPILSMF 584
R+L A+A+D++ F + KV G P A+L + + +L +L L+ +A ++++F
Sbjct: 367 RILHALARDDL--FGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVF 424
Query: 585 FLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLI 644
+L+ Y V+L+C PN+RP F + W LG++ CL +MF+ S A ++L+
Sbjct: 425 YLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLL 484
Query: 645 AGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDL 704
G++ + +G WG + L R LLRL+ H K WRPQLL+L
Sbjct: 485 MGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLL------- 537
Query: 705 HVKYPR----LLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ--TIKNMMEIEKV 758
V PR LL A+QLK G GL ++G V G L+S Q ++++ +V
Sbjct: 538 -VGNPRGALPLLRLANQLKKG-GLYVLGHVTLGD-LDSLPSDPVQPQYGAWLSLVDRAQV 594
Query: 759 KGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGW 795
K F + ++ VR+G HL++ GLGGM+ N++VLG+
Sbjct: 595 KAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGF 631
>gi|186910319 solute carrier family 12, member 3 isoform 3 [Homo
sapiens]
Length = 1021
Score = 236 bits (603), Expect = 7e-62
Identities = 194/732 (26%), Positives = 313/732 (42%), Gaps = 123/732 (16%)
Query: 419 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACI- 477
+F + IFFPS TGI+AG+N SGDL+D +IP GT++AI T++ Y + G+C+
Sbjct: 339 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVV 398
Query: 478 --EGVVLRDKY--GDGVSRNLVVG-----------------------TLAWPSPW--VIV 508
VL D G G L T++ S + +I
Sbjct: 399 RDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLIT 458
Query: 509 IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK-VNGEPTWALLLTALIAEL 567
G F +T + L L A ++ Q + +D + P + FG G N EP LL IA
Sbjct: 459 AGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVA 518
Query: 568 GILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCL 627
I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G + +
Sbjct: 519 FIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISV 578
Query: 628 ALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHT 687
+MF+ +W+ AL+A+ + + Y+ Y+ E WG ++ S + A + L E H
Sbjct: 579 VIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHI 638
Query: 688 KNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ 747
KN+RPQ LVL P L+ F L I G V+ G + E Q
Sbjct: 639 KNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIAN 694
Query: 748 TIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRA 807
+ K+K F V+A +R G+ L+Q+ GLG M+ N +V+G+ W QS P
Sbjct: 695 GHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPAT 753
Query: 808 WKTFIDTVR---------CTTAAHLALLVPK------NIAFYPSNHERYLEGH------- 845
+ +I + C L V K N F P+ +
Sbjct: 754 VEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARVDPKALV 813
Query: 846 -----------------IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNS 888
ID++W+ DGG+ +L+P+LL + + W KC++R+F Q++
Sbjct: 814 KEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQIN--- 870
Query: 889 IQMKKDLAVFLYHLRLEAEHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVK 948
R++ E + IS + R E + + R + +
Sbjct: 871 --------------RMDQERKAIISLLSKFRLGFHEVHI----LPDINQNPRAEHTKRFE 912
Query: 949 DRHSALRLESLYSDEEDESAVGADKIQMTW-TRDKYMTETWDPSHAPDNFRELVHIKPDQ 1007
D + RL + +DE+ V + W D+ +T+
Sbjct: 913 DMIAPFRLNDGF---KDEATVNEMRRDCPWKISDEEITK--------------------- 948
Query: 1008 SNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLE-RVLL 1066
N + V+LNE+++ S DA L+++ +P + YM +LE L++ L V+L
Sbjct: 949 -NRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVIL 1007
Query: 1067 VRGGGREVITIY 1078
+RG V+T Y
Sbjct: 1008 IRGNQENVLTFY 1019
Score = 125 bits (315), Expect = 2e-28
Identities = 69/198 (34%), Positives = 111/198 (56%), Gaps = 17/198 (8%)
Query: 101 EAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC 160
E E+G + + E G + GV + C+ NI+GVIL+LRL W+ AG++ +I+L+
Sbjct: 119 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 178
Query: 161 CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGA 220
T +T +S+SAI+TNG V +GG+YF+ISRSLGPE GG++GL F AM+ +G
Sbjct: 179 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 238
Query: 221 IE----ILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKF 276
E +L Y AP I P +N++R+ G + +T + + G+++ +K
Sbjct: 239 AETVRDLLQEYGAP---IVDP----------INDIRIIGVVSVTVLLAISLAGMEWESKA 285
Query: 277 ASLFLACVIISILSIYAG 294
LF +++S + G
Sbjct: 286 QVLFFLVIMVSFANYLVG 303
>gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo
sapiens]
Length = 1029
Score = 233 bits (594), Expect = 7e-61
Identities = 194/741 (26%), Positives = 313/741 (42%), Gaps = 132/741 (17%)
Query: 419 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACI- 477
+F + IFFPS TGI+AG+N SGDL+D +IP GT++AI T++ Y + G+C+
Sbjct: 338 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVV 397
Query: 478 --EGVVLRDKY--GDGVSRNLVVG-----------------------TLAWPSPW--VIV 508
VL D G G L T++ S + +I
Sbjct: 398 RDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLIT 457
Query: 509 IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK-VNGEPTWALLLTALIAEL 567
G F +T + L L A ++ Q + +D + P + FG G N EP LL IA
Sbjct: 458 AGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVA 517
Query: 568 GILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCL 627
I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G + +
Sbjct: 518 FIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISV 577
Query: 628 ALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHT 687
+MF+ +W+ AL+A+ + + Y+ Y+ E WG ++ S + A + L E H
Sbjct: 578 VIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHI 637
Query: 688 KNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ 747
KN+RPQ LVL P L+ F L I G V+ G + E Q
Sbjct: 638 KNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIAN 693
Query: 748 TIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRA 807
+ K+K F V+A +R G+ L+Q+ GLG M+ N +V+G+ W QS P
Sbjct: 694 GHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPAT 752
Query: 808 WKTFIDTVR---------CTTAAHLALLVPK------NIAFYPSNHERYLEGH------- 845
+ +I + C L V K N F P+ +
Sbjct: 753 VEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGARPSVS 812
Query: 846 --------------------------IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF 879
ID++W+ DGG+ +L+P+LL + + W KC++R+F
Sbjct: 813 GALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVF 872
Query: 880 TVAQMDDNSIQMKKDLAVFLYHLRLEAEHNSDISAYTYERTLMMEQRSQMLRQMRLTKTE 939
Q++ R++ E + IS + R E + +
Sbjct: 873 VGGQIN-----------------RMDQERKAIISLLSKFRLGFHEVHI----LPDINQNP 911
Query: 940 REREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTW-TRDKYMTETWDPSHAPDNFR 998
R + +D + RL + +DE+ V + W D+ +T+
Sbjct: 912 RAEHTKRFEDMIAPFRLNDGF---KDEATVNEMRRDCPWKISDEEITK------------ 956
Query: 999 ELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLT 1058
N + V+LNE+++ S DA L+++ +P + YM +LE L+
Sbjct: 957 ----------NRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLS 1006
Query: 1059 EGLE-RVLLVRGGGREVITIY 1078
+ L V+L+RG V+T Y
Sbjct: 1007 QDLRPPVILIRGNQENVLTFY 1027
Score = 125 bits (315), Expect = 2e-28
Identities = 69/198 (34%), Positives = 111/198 (56%), Gaps = 17/198 (8%)
Query: 101 EAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC 160
E E+G + + E G + GV + C+ NI+GVIL+LRL W+ AG++ +I+L+
Sbjct: 118 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 177
Query: 161 CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGA 220
T +T +S+SAI+TNG V +GG+YF+ISRSLGPE GG++GL F AM+ +G
Sbjct: 178 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 237
Query: 221 IE----ILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKF 276
E +L Y AP I P +N++R+ G + +T + + G+++ +K
Sbjct: 238 AETVRDLLQEYGAP---IVDP----------INDIRIIGVVSVTVLLAISLAGMEWESKA 284
Query: 277 ASLFLACVIISILSIYAG 294
LF +++S + G
Sbjct: 285 QVLFFLVIMVSFANYLVG 302
>gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo
sapiens]
Length = 1030
Score = 233 bits (594), Expect = 7e-61
Identities = 194/741 (26%), Positives = 313/741 (42%), Gaps = 132/741 (17%)
Query: 419 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACI- 477
+F + IFFPS TGI+AG+N SGDL+D +IP GT++AI T++ Y + G+C+
Sbjct: 339 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVV 398
Query: 478 --EGVVLRDKY--GDGVSRNLVVG-----------------------TLAWPSPW--VIV 508
VL D G G L T++ S + +I
Sbjct: 399 RDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLIT 458
Query: 509 IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK-VNGEPTWALLLTALIAEL 567
G F +T + L L A ++ Q + +D + P + FG G N EP LL IA
Sbjct: 459 AGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVA 518
Query: 568 GILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCL 627
I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G + +
Sbjct: 519 FIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISV 578
Query: 628 ALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHT 687
+MF+ +W+ AL+A+ + + Y+ Y+ E WG ++ S + A + L E H
Sbjct: 579 VIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHI 638
Query: 688 KNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ 747
KN+RPQ LVL P L+ F L I G V+ G + E Q
Sbjct: 639 KNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIAN 694
Query: 748 TIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRA 807
+ K+K F V+A +R G+ L+Q+ GLG M+ N +V+G+ W QS P
Sbjct: 695 GHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPAT 753
Query: 808 WKTFIDTVR---------CTTAAHLALLVPK------NIAFYPSNHERYLEGH------- 845
+ +I + C L V K N F P+ +
Sbjct: 754 VEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGARPSVS 813
Query: 846 --------------------------IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF 879
ID++W+ DGG+ +L+P+LL + + W KC++R+F
Sbjct: 814 GALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVF 873
Query: 880 TVAQMDDNSIQMKKDLAVFLYHLRLEAEHNSDISAYTYERTLMMEQRSQMLRQMRLTKTE 939
Q++ R++ E + IS + R E + +
Sbjct: 874 VGGQIN-----------------RMDQERKAIISLLSKFRLGFHEVHI----LPDINQNP 912
Query: 940 REREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTW-TRDKYMTETWDPSHAPDNFR 998
R + +D + RL + +DE+ V + W D+ +T+
Sbjct: 913 RAEHTKRFEDMIAPFRLNDGF---KDEATVNEMRRDCPWKISDEEITK------------ 957
Query: 999 ELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLT 1058
N + V+LNE+++ S DA L+++ +P + YM +LE L+
Sbjct: 958 ----------NRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLS 1007
Query: 1059 EGLE-RVLLVRGGGREVITIY 1078
+ L V+L+RG V+T Y
Sbjct: 1008 QDLRPPVILIRGNQENVLTFY 1028
Score = 125 bits (315), Expect = 2e-28
Identities = 69/198 (34%), Positives = 111/198 (56%), Gaps = 17/198 (8%)
Query: 101 EAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC 160
E E+G + + E G + GV + C+ NI+GVIL+LRL W+ AG++ +I+L+
Sbjct: 119 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 178
Query: 161 CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGA 220
T +T +S+SAI+TNG V +GG+YF+ISRSLGPE GG++GL F AM+ +G
Sbjct: 179 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 238
Query: 221 IE----ILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKF 276
E +L Y AP I P +N++R+ G + +T + + G+++ +K
Sbjct: 239 AETVRDLLQEYGAP---IVDP----------INDIRIIGVVSVTVLLAISLAGMEWESKA 285
Query: 277 ASLFLACVIISILSIYAG 294
LF +++S + G
Sbjct: 286 QVLFFLVIMVSFANYLVG 303
>gi|4506975 solute carrier family 12 (sodium/potassium/chloride
transporters), member 2 [Homo sapiens]
Length = 1212
Score = 231 bits (588), Expect = 4e-60
Identities = 148/420 (35%), Positives = 214/420 (50%), Gaps = 44/420 (10%)
Query: 419 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIE 478
+F + IFFP+ TGI+AG+N SGDL D Q +IP GT+LAI+ T+LVY V G+C
Sbjct: 486 TFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSC-- 543
Query: 479 GVVLRDKYGD---------------------------------GVSRNLVVGTLAWPSPW 505
V+RD G+ G+ N V ++
Sbjct: 544 --VVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTP 601
Query: 506 VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHGKVNGEPTWALLLTAL 563
+I G F +T + L SL AP++ QA+ KDNI P ++F G+GK N EP +LT L
Sbjct: 602 LISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGK-NNEPLRGYILTFL 660
Query: 564 IAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGM 623
IA ILIA L+++API+S FFL Y +N + +L ++P WRP FKYY+ +S LG
Sbjct: 661 IALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGA 720
Query: 624 SLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEG 683
LC +MFV +W+ AL+ +I +Y Y+ Y+ + WG + L+ A +RL
Sbjct: 721 ILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGV 780
Query: 684 PPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQ 743
H KN+RPQ LV+ P LL GL I G V G ++ E
Sbjct: 781 EDHVKNFRPQCLVMTGAPN----SRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMS 836
Query: 744 AAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSE 803
+ + + K+K F V A +REG +L+Q+ GLG M+ N++VLG+ W Q++
Sbjct: 837 IDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQAD 896
Score = 130 bits (326), Expect = 9e-30
Identities = 76/239 (31%), Positives = 131/239 (54%), Gaps = 13/239 (5%)
Query: 53 LEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRA 112
++A ID+Y A E+L +RP ++ L +L A E + +
Sbjct: 218 MDAVPRIDHYRHTAAQLGEKL-LRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYT 276
Query: 113 AEAPSM---GTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAI 169
AE+ + G + GV + C+ NI+GV+LF+RL+W+VG AG+ ++L++++ T +T +
Sbjct: 277 AESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGL 336
Query: 170 SMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIA 229
S SAIATNG V GG+Y++ISRSLGPEFGGA+GL F A AMY++G E ++ +
Sbjct: 337 STSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLK 396
Query: 230 PPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISI 288
+ + +N++R+ G I + + + G+++ K + L ++++I
Sbjct: 397 EHSILMIDE---------INDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAI 446
Score = 74.7 bits (182), Expect = 4e-13
Identities = 56/234 (23%), Positives = 104/234 (44%), Gaps = 45/234 (19%)
Query: 846 IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLE 905
IDVWW+ DGG+ +L+P+LL K W+ C++R+F +++
Sbjct: 1024 IDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKIN-------------------R 1064
Query: 906 AEHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEED 965
+H+ A TL+ + R M L + + + + + L+ D+++
Sbjct: 1065 IDHDRRAMA-----TLLSKFRIDFSDIMVLGDINTKPKKENIIAFEEIIEPYRLHEDDKE 1119
Query: 966 ESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVT 1025
+ ADK++ +P DN EL K + ++LNE++
Sbjct: 1120 QDI--ADKMKED-----------EPWRITDNELELYKTK--------TYRQIRLNELLKE 1158
Query: 1026 RSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1079
S A ++++++P + + YM +LE L++ L +LLVRG + V+T YS
Sbjct: 1159 HSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSVLTFYS 1212
>gi|134254459 sodium potassium chloride cotransporter 2 [Homo
sapiens]
Length = 1099
Score = 212 bits (540), Expect = 1e-54
Identities = 139/418 (33%), Positives = 203/418 (48%), Gaps = 44/418 (10%)
Query: 420 FTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEG 479
F + IFFP+ TGI+AG+N SGDL D Q +IP GT+LAI T++ Y + GAC
Sbjct: 380 FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGAC--- 436
Query: 480 VVLRDKYGD---------------------------------GVSRNLVVGTLAWPSPWV 506
V+RD G+ G+ N V ++ +
Sbjct: 437 -VVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPL 495
Query: 507 IVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHGKVNGEPTWALLLTALI 564
I G F +T + L SL AP++ QA+ KDNI L+ F G+GK N EP +LT LI
Sbjct: 496 ITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGK-NNEPLRGYILTFLI 554
Query: 565 AELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMS 624
A ILIA L+ +API+S FFL Y +N +C + ++P WRP + Y+ +S G
Sbjct: 555 AMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAV 614
Query: 625 LCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGP 684
LC A+MFV +W+ A++ +I +Y Y+ + + WG + LS +A L L
Sbjct: 615 LCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVE 674
Query: 685 PHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQA 744
H KN+RPQ +VL + P LL GL I V G E +
Sbjct: 675 DHVKNFRPQCIVL----TGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNS 730
Query: 745 AEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQS 802
+ + K+K F V A R+G+ L+Q+ GLG M+ N++V+G+ WR++
Sbjct: 731 GMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKA 788
Score = 132 bits (331), Expect = 2e-30
Identities = 91/295 (30%), Positives = 150/295 (50%), Gaps = 33/295 (11%)
Query: 17 YDNLEGLSWVDYGERAELDDS----DGHGNHRESSPF-LSPLEASRGIDYYDRNLALFEE 71
YDN ++ GE A+ D S D H N F + ++A I+YY RN
Sbjct: 70 YDN-----FLQSGETAKTDASFHAYDSHTNTYYLQTFGHNTMDAVPKIEYY-RNTGSISG 123
Query: 72 ELDIRPKVSSLLGKLVSYTNLTQGAKEH----------EEAESGEGTRRRAAEAPSMGTL 121
RP + + +L +T + + E+AE+ E + A G +
Sbjct: 124 PKVNRPSLLEIHEQLAKNVAVTPSSADRVANGDGIPGDEQAENKEDDQ---AGVVKFGWV 180
Query: 122 MGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVP 181
GV + C+ NI+GV+LF+RL+W+VG AG+ +LI+L+ T +T +S SAIATNG V
Sbjct: 181 KGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVR 240
Query: 182 AGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAH 241
GG+Y++ISRSLGPEFGG++GL F A AMY++G E ++ + ++
Sbjct: 241 GGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVD---- 296
Query: 242 DTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGI 296
N++R+ G+I + + + G+++ K + L ++I+I + + G +
Sbjct: 297 -----PTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTV 346
Score = 77.4 bits (189), Expect = 7e-14
Identities = 66/239 (27%), Positives = 112/239 (46%), Gaps = 49/239 (20%)
Query: 843 EGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHL 902
+G IDVWW+ DGG+ +L+P++L K W+ C++RI+ +++
Sbjct: 908 KGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKIN----------------- 950
Query: 903 RLEAEHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSD 962
R+E E ++M + +L + R+ + + ++ D + ES
Sbjct: 951 RIE------------EEKIVM---ASLLSKFRI----KFADIHIIGDINIRPNKESWKVF 991
Query: 963 EED-ESAVGADKIQMTWTRDKYMTET-WDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLN 1020
EE E + + T +K ET W + A EL +K + + V+LN
Sbjct: 992 EEMIEPYRLHESCKDLTTAEKLKRETPWKITDA-----ELEAVK------EKSYRQVRLN 1040
Query: 1021 EVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1079
E++ S A L++L++P + S D YM +LE+LT+ L VLLVRG + V+T YS
Sbjct: 1041 ELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1099
>gi|38569457 solute carrier family 12, member 8 [Homo sapiens]
Length = 714
Score = 102 bits (253), Expect = 3e-21
Identities = 57/176 (32%), Positives = 99/176 (56%), Gaps = 9/176 (5%)
Query: 419 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIE 478
SF + G+FFP+ TG+MAG N GDLR+ SIP+G++ A+ + +Y V L GA
Sbjct: 232 SFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICT 291
Query: 479 GVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNI 538
LR + ++ ++ ++G + S+ + + L GAPR+LQ IA++ +
Sbjct: 292 REALR--------YDFLIAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKV 343
Query: 539 IPFLRVFGHGK-VNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVN 593
IP L G GK N P A+ LT+L+ + + ++++API+++ F++ Y+ V+
Sbjct: 344 IPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVD 399
Score = 86.7 bits (213), Expect = 1e-16
Identities = 44/104 (42%), Positives = 58/104 (55%)
Query: 119 GTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNG 178
GT GV+ C+ NIFGV+LFLR W+VG GVL + +V L+T +S +
Sbjct: 40 GTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERS 99
Query: 179 VVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIE 222
+ +GG Y MIS LG + GG +GL + G A AMYI G E
Sbjct: 100 SIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAE 143
Score = 34.3 bits (77), Expect = 0.65
Identities = 20/51 (39%), Positives = 26/51 (50%), Gaps = 6/51 (11%)
Query: 607 WRPRFKYYH-----WALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYI 652
WR +Y W +S LG L +MFV W Y LV M +A ++Y YI
Sbjct: 582 WRRSTSFYTHMCNPW-VSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYI 631
>gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo
sapiens]
Length = 697
Score = 50.8 bits (120), Expect = 7e-06
Identities = 47/187 (25%), Positives = 82/187 (43%), Gaps = 16/187 (8%)
Query: 413 VADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVL 472
+A AT F VG + TG ++R+ QK+IP+G + +++ + YF
Sbjct: 298 LAGAATCFYAFVGFDCIATTG--------EEVRNPQKAIPIGIVTSLLVCFMAYFGVSAA 349
Query: 473 FGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQ 531
+ +L +K V+ V W P+ +V+ GS + + L S+ PR+L
Sbjct: 350 LTLMMPYYLLDEKSPLPVAFEYV----GWGPAKYVVAAGSLCALSTSLLGSMFPLPRILF 405
Query: 532 AIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLF 591
A+A+D ++ R P A L +I+ L + L + ++S+ LM Y
Sbjct: 406 AMARDGLL--FRFLARVSKRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSL 463
Query: 592 VNLACAV 598
V AC +
Sbjct: 464 V-AACVL 469
>gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo
sapiens]
Length = 658
Score = 47.4 bits (111), Expect = 7e-05
Identities = 46/187 (24%), Positives = 83/187 (44%), Gaps = 15/187 (8%)
Query: 413 VADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVL 472
+A AT F VG + TG ++R+ QK+IP+G + +++ + YF
Sbjct: 258 LAGAATCFYAFVGFDCIATTG--------EEVRNPQKAIPIGIVTSLLVCFMAYFGVSAA 309
Query: 473 FGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQ 531
+ +L +K V+ V W P+ +V+ GS + + L S+ PR++
Sbjct: 310 LTLMMPYYLLDEKSPLPVAFEYV----GWGPAKYVVAAGSLCALSTSLLGSIFPMPRVIY 365
Query: 532 AIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLF 591
A+A+D ++ F + P A L + +A L + L + ++S+ LM Y
Sbjct: 366 AMAEDGLL-FKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTLMAYSL 424
Query: 592 VNLACAV 598
V AC +
Sbjct: 425 V-AACVL 430
>gi|114326550 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 3 [Homo sapiens]
Length = 619
Score = 39.3 bits (90), Expect = 0.020
Identities = 42/189 (22%), Positives = 84/189 (44%), Gaps = 16/189 (8%)
Query: 412 VVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVV 471
++ AT F VG + TG A ++ Q+SIP+G ++++ L YF+
Sbjct: 253 ILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSIPMGIVISLSVCFLAYFAVSS 304
Query: 472 LFGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLL 530
+ L+ + L +G W P+ +V+ +GS + + L S+ PR++
Sbjct: 305 ALTLMMPYYQLQPE-SPLPEAFLYIG---WAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360
Query: 531 QAIAKDNIIPFLRVFGHGKVNGE-PTWALLLTALIAELGILIASLDMVAPILSMFFLMCY 589
A+A+D ++ RV P A +++ +IA + L + ++S+ L+ Y
Sbjct: 361 YAMAEDGLL--FRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAY 418
Query: 590 LFVNLACAV 598
V++ +
Sbjct: 419 SLVSICVLI 427
>gi|114326544 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 3 [Homo sapiens]
Length = 619
Score = 39.3 bits (90), Expect = 0.020
Identities = 42/189 (22%), Positives = 84/189 (44%), Gaps = 16/189 (8%)
Query: 412 VVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVV 471
++ AT F VG + TG A ++ Q+SIP+G ++++ L YF+
Sbjct: 253 ILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSIPMGIVISLSVCFLAYFAVSS 304
Query: 472 LFGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLL 530
+ L+ + L +G W P+ +V+ +GS + + L S+ PR++
Sbjct: 305 ALTLMMPYYQLQPE-SPLPEAFLYIG---WAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360
Query: 531 QAIAKDNIIPFLRVFGHGKVNGE-PTWALLLTALIAELGILIASLDMVAPILSMFFLMCY 589
A+A+D ++ RV P A +++ +IA + L + ++S+ L+ Y
Sbjct: 361 YAMAEDGLL--FRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAY 418
Query: 590 LFVNLACAV 598
V++ +
Sbjct: 419 SLVSICVLI 427
>gi|4507047 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 1 [Homo sapiens]
Length = 629
Score = 38.1 bits (87), Expect = 0.045
Identities = 44/209 (21%), Positives = 91/209 (43%), Gaps = 29/209 (13%)
Query: 412 VVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFS--- 468
V++ AT F VG + TG ++++ QK+IPVG + +++ + YF
Sbjct: 255 VLSGAATCFYAFVGFDCIATTG--------EEVKNPQKAIPVGIVASLLICFIAYFGVSA 306
Query: 469 --SVVLFGACIE-GVVLRDKYGDGVSRNLVVGTLAWP-SPWVIVIGSFFSTCGAGLQSLT 524
++++ C++ L D + + W + + + +GS + + L S+
Sbjct: 307 ALTLMMPYFCLDNNSPLPDAFKH----------VGWEGAKYAVAVGSLCALSASLLGSMF 356
Query: 525 GAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMF 584
PR++ A+A+D ++ F + P A L + +A + + L + ++S+
Sbjct: 357 PMPRVIYAMAEDGLL-FKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIG 415
Query: 585 FLMCYLFVNLACAVQTLLRTPNWRPRFKY 613
L+ Y +L A +LR +P Y
Sbjct: 416 TLLAY---SLVAACVLVLRYQPEQPNLVY 441
>gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens]
Length = 1115
Score = 37.4 bits (85), Expect = 0.077
Identities = 58/248 (23%), Positives = 101/248 (40%), Gaps = 37/248 (14%)
Query: 58 GIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPS 117
GID ++ ++ L+ +V L + + ++ Q K+H R + S
Sbjct: 603 GIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYS 662
Query: 118 --MGTLMGVYLPCLQNIFGVILFLRL------TWMVGT-AGVLQALLIVLICC----CCT 164
+ G Y+ C +F I F++L T M+G A + LLI ++ C C +
Sbjct: 663 RKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSCGS 722
Query: 165 L----LTAISMSAIATNGVVPAGGSYFMI----SRSLGPEFGGAVGLCFYLGTTFA---- 212
L L +S S + + A G + ++ S F G + L + F
Sbjct: 723 LFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMYFIGNMLLSLLASSVFLHISS 782
Query: 213 ----AAMYILGAIEILLTYIAPPAAIF----YPSGAHD--TSNATLNNM--RVYGTIFLT 260
A +++LG I ++L + PPA IF G H +SN T + + G + L
Sbjct: 783 IGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALK 842
Query: 261 FMTLVVFV 268
+MT V+ +
Sbjct: 843 YMTPVILL 850
>gi|181337167 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 14 [Homo sapiens]
Length = 771
Score = 36.2 bits (82), Expect = 0.17
Identities = 40/184 (21%), Positives = 75/184 (40%), Gaps = 14/184 (7%)
Query: 412 VVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVV 471
V+ AT F +G + TG A ++ SIP +++ Y S V
Sbjct: 254 VLQGAATCFYAFIGFDIIATTGEEA--------KNPNTSIPYAITASLVICLTAYVSVSV 305
Query: 472 LFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQ 531
+ + + + + V + + +V+ IGS + L SL PR++
Sbjct: 306 ILTLMVPYYTIDT---ESPLMEMFVAHGFYAAKFVVAIGSVAGLTVSLLGSLFPMPRVIY 362
Query: 532 AIAKDNIIPFLRVFGH-GKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYL 590
A+A D ++ R H P A +++ +A L L+ SL + ++S+ L+ Y
Sbjct: 363 AMAGDGLL--FRFLAHVSSYTETPVVACIVSGFLAALLALLVSLRDLIEMMSIGTLLAYT 420
Query: 591 FVNL 594
V++
Sbjct: 421 LVSV 424
>gi|239748340 PREDICTED: hypothetical protein XP_002346633 [Homo
sapiens]
Length = 465
Score = 35.0 bits (79), Expect = 0.38
Identities = 37/151 (24%), Positives = 64/151 (42%), Gaps = 20/151 (13%)
Query: 893 KDLAVFLYHLRLEAEHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHS 952
K LA+ + LR HN + + E++ + +Q L K +ER +Q ++
Sbjct: 129 KKLALGYHFLR----HNKKVDFQDTNARSLAERKREEEKQKHLDKIYQERASQAEREMQQ 184
Query: 953 ALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIK--PDQSN- 1009
L DE+DE V + E ++P H PD+ R ++ P++
Sbjct: 185 TEALGDAEEDEDDEDFVEVPE-----------KEGYEP-HIPDHLRPEYGLEAAPEKDTV 232
Query: 1010 VRRMHTAVKLNEVIVTRSHDARLVLLNMPGP 1040
VR + T +++E V+ A L +PGP
Sbjct: 233 VRCLRTRTRMDEE-VSDPTSAAAQLRQLPGP 262
>gi|187423910 solute carrier family 7, member 9 [Homo sapiens]
Length = 487
Score = 32.7 bits (73), Expect = 1.9
Identities = 34/168 (20%), Positives = 66/168 (39%), Gaps = 6/168 (3%)
Query: 443 DLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWP 502
+LR+ +++P+ I+ I + Y V + + L V+ + +P
Sbjct: 244 ELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATELLQSQAVAVTFG---DRVLYP 300
Query: 503 SPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNG-EPTWALLLT 561
+ W++ + FST GA + A RL+ ++ L+V + V P A++
Sbjct: 301 ASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREG--HMLKVLSYISVRRLTPAPAIIFY 358
Query: 562 ALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRP 609
+IA + I+ ++ + S + Y L V R RP
Sbjct: 359 GIIATIYIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRFTRKELERP 406
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,496,803
Number of Sequences: 37866
Number of extensions: 1727483
Number of successful extensions: 4357
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 4245
Number of HSP's gapped (non-prelim): 85
length of query: 1079
length of database: 18,247,518
effective HSP length: 113
effective length of query: 966
effective length of database: 13,968,660
effective search space: 13493725560
effective search space used: 13493725560
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.