Search of human proteins with 22538467

Search of human proteins with 22538467

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|22538467 proteasome beta 4 subunit [Homo sapiens]
         (264 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|22538467 proteasome beta 4 subunit [Homo sapiens]                  533   e-152
gi|73747875 proteasome beta 8 subunit isoform E2 proprotein [Hom...    55   8e-08
gi|4758970 proteasome beta 8 subunit isoform E1 proprotein [Homo...    55   8e-08
gi|4506195 proteasome beta 2 subunit [Homo sapiens]                    53   3e-07
gi|4506201 proteasome beta 5 subunit isoform 1 [Homo sapiens]          52   5e-07
gi|4506203 proteasome beta 7 subunit proprotein [Homo sapiens]         43   2e-04
gi|23110932 proteasome beta 9 subunit isoform 2 proprotein [Homo...    40   0.003
gi|4506205 proteasome beta 9 subunit isoform 1 proprotein [Homo ...    40   0.003
gi|23110925 proteasome beta 6 subunit [Homo sapiens]                   39   0.006
gi|222144262 proteasome beta 5 subunit isoform 3 [Homo sapiens]        38   0.010
gi|153791216 proteasome beta 11 subunit [Homo sapiens]                 33   0.20 
gi|4506191 proteasome beta 10 subunit proprotein [Homo sapiens]        33   0.20 
gi|207452735 epiplakin 1 [Homo sapiens]                                29   3.7  
gi|21704287 sialidase 4 [Homo sapiens]                                 28   6.3  

>gi|22538467 proteasome beta 4 subunit [Homo sapiens]
          Length = 264

 Score =  533 bits (1372), Expect = e-152
 Identities = 264/264 (100%), Positives = 264/264 (100%)

Query: 1   MEAFLGSRSGLWAGGPAPGQFYRIPSTPDSFMDPASALYRGPITRTQNPMVTGTSVLGVK 60
           MEAFLGSRSGLWAGGPAPGQFYRIPSTPDSFMDPASALYRGPITRTQNPMVTGTSVLGVK
Sbjct: 1   MEAFLGSRSGLWAGGPAPGQFYRIPSTPDSFMDPASALYRGPITRTQNPMVTGTSVLGVK 60

Query: 61  FEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVLGQMVIDEE 120
           FEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVLGQMVIDEE
Sbjct: 61  FEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVLGQMVIDEE 120

Query: 121 LLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAP 180
           LLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAP
Sbjct: 121 LLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAP 180

Query: 181 SLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSYNRFQIATVTEK 240
           SLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSYNRFQIATVTEK
Sbjct: 181 SLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSYNRFQIATVTEK 240

Query: 241 GVEIEGPLSTETNWDIAHMISGFE 264
           GVEIEGPLSTETNWDIAHMISGFE
Sbjct: 241 GVEIEGPLSTETNWDIAHMISGFE 264


>gi|73747875 proteasome beta 8 subunit isoform E2 proprotein [Homo
           sapiens]
          Length = 276

 Score = 54.7 bits (130), Expect = 8e-08
 Identities = 61/213 (28%), Positives = 93/213 (43%), Gaps = 10/213 (4%)

Query: 47  QNPMVTGTSVLGVKFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQ 106
           Q  M  GT+ L  KF+ GV+ A D   S GS      +++++ +N   +   SG  AD Q
Sbjct: 66  QIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQ 125

Query: 107 YLKQVLGQMVIDEELLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESF 166
           Y +++L +       L +G   S  A    L+  M   R  M     +M+ G    G   
Sbjct: 126 YWERLLAK-ECRLYYLRNGERISVSAASKLLSNMMCQYRG-MGLSMGSMICGWDKKGPG- 182

Query: 167 LGYVDMLGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDA 226
           L YVD  G        +TG G   A  ++      +P LS  EA DL  R +    +RD+
Sbjct: 183 LYYVDEHGTRLSGNMFSTGSGNTYAYGVMDS--GYRPNLSPEEAYDLGRRAIAYATHRDS 240

Query: 227 RSYNRFQIATVTEKG-VEIEGPLSTETNWDIAH 258
            S     +  + E G V++E   ST+ + D+ H
Sbjct: 241 YSGGVVNMYHMKEDGWVKVE---STDVS-DLLH 269


>gi|4758970 proteasome beta 8 subunit isoform E1 proprotein [Homo
           sapiens]
          Length = 272

 Score = 54.7 bits (130), Expect = 8e-08
 Identities = 61/213 (28%), Positives = 93/213 (43%), Gaps = 10/213 (4%)

Query: 47  QNPMVTGTSVLGVKFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQ 106
           Q  M  GT+ L  KF+ GV+ A D   S GS      +++++ +N   +   SG  AD Q
Sbjct: 62  QIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQ 121

Query: 107 YLKQVLGQMVIDEELLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESF 166
           Y +++L +       L +G   S  A    L+  M   R  M     +M+ G    G   
Sbjct: 122 YWERLLAK-ECRLYYLRNGERISVSAASKLLSNMMCQYRG-MGLSMGSMICGWDKKGPG- 178

Query: 167 LGYVDMLGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDA 226
           L YVD  G        +TG G   A  ++      +P LS  EA DL  R +    +RD+
Sbjct: 179 LYYVDEHGTRLSGNMFSTGSGNTYAYGVMDS--GYRPNLSPEEAYDLGRRAIAYATHRDS 236

Query: 227 RSYNRFQIATVTEKG-VEIEGPLSTETNWDIAH 258
            S     +  + E G V++E   ST+ + D+ H
Sbjct: 237 YSGGVVNMYHMKEDGWVKVE---STDVS-DLLH 265


>gi|4506195 proteasome beta 2 subunit [Homo sapiens]
          Length = 201

 Score = 52.8 bits (125), Expect = 3e-07
 Identities = 39/188 (20%), Positives = 85/188 (45%), Gaps = 4/188 (2%)

Query: 56  VLGVKFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVLGQM 115
           ++G++    V++A+D + +   +    +  ++ +++   +L   G+  D     + + Q 
Sbjct: 4   LIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYI-QK 62

Query: 116 VIDEELLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGES-FLGYVDMLG 174
            +    + +G+  SP A  ++  R +        P    +++ GY + E   L Y+D L 
Sbjct: 63  NVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLA 122

Query: 175 VAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSYNRFQI 234
              +AP  A GYGA+L   +L       P +S+  A +L+ +C+  L  R   +   F +
Sbjct: 123 ALAKAPFAAHGYGAFLTLSILDRYY--TPTISRERAVELLRKCLEELQKRFILNLPTFSV 180

Query: 235 ATVTEKGV 242
             + + G+
Sbjct: 181 RIIDKNGI 188


>gi|4506201 proteasome beta 5 subunit isoform 1 [Homo sapiens]
          Length = 263

 Score = 52.0 bits (123), Expect = 5e-07
 Identities = 49/192 (25%), Positives = 80/192 (41%), Gaps = 5/192 (2%)

Query: 50  MVTGTSVLGVKFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLK 109
           M+ GT+ L  KF  GV++AAD   + G+    + + +++ +N   +   +G  AD  + +
Sbjct: 56  MLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWE 115

Query: 110 QVLGQMVIDEELLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGY 169
           ++L +     E L +    S  A    L   +Y  +  M     TM+ G    G   L Y
Sbjct: 116 RLLARQCRIYE-LRNKERISVAAASKLLANMVYQYKG-MGLSMGTMICGWDKRGPG-LYY 172

Query: 170 VDMLGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSY 229
           VD  G      + + G G+  A  ++         L   +A DL  R +    YRDA S 
Sbjct: 173 VDSEGNRISGATFSVGSGSVYAYGVMDRGYSYD--LEVEQAYDLARRAIYQATYRDAYSG 230

Query: 230 NRFQIATVTEKG 241
               +  V E G
Sbjct: 231 GAVNLYHVREDG 242


>gi|4506203 proteasome beta 7 subunit proprotein [Homo sapiens]
          Length = 277

 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 39/198 (19%), Positives = 86/198 (43%), Gaps = 10/198 (5%)

Query: 52  TGTSVLGVKFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQV 111
           TGT++ GV ++ G+V+ AD   + G +   +N S+I  ++ +     +G  AD     Q+
Sbjct: 42  TGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQL 101

Query: 112 LGQMVIDEELLGDGHSYSPRAI--HSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGY 169
           +   +   EL        PR +  +  L + ++  +  +      +V+GG       L  
Sbjct: 102 ISSNL---ELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGA---ALVLGGVDVTGPHLYS 155

Query: 170 VDMLGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSY 229
           +   G   + P +  G G+  A  +  +  + +P + + EA++LV   +    + D  S 
Sbjct: 156 IYPHGSTDKLPYVTMGSGSLAAMAVFED--KFRPDMEEEEAKNLVSEAIAAGIFNDLGSG 213

Query: 230 NRFQIATVTEKGVEIEGP 247
           +   +  +++  ++   P
Sbjct: 214 SNIDLCVISKNKLDFLRP 231


>gi|23110932 proteasome beta 9 subunit isoform 2 proprotein [Homo
           sapiens]
          Length = 209

 Score = 39.7 bits (91), Expect = 0.003
 Identities = 43/194 (22%), Positives = 76/194 (39%), Gaps = 10/194 (5%)

Query: 52  TGTSVLGVKFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQV 111
           TGT+++ V+F+GGVV+ +D   S G     R   ++  ++       SG  AD Q +  +
Sbjct: 9   TGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADM 68

Query: 112 LGQMVIDEELLGDGHSYSP--RAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGY 169
               +   EL G      P   A  + +    Y  R  ++     +++ G+   E    Y
Sbjct: 69  AAYQL---ELHGIELEEPPLVLAAANVVRNISYKYREDLSA---HLMVAGWDQREGGQVY 122

Query: 170 VDMLGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSY 229
             + G+    P    G G+      +      +P +S  E R      + +   RD  S 
Sbjct: 123 GTLGGMLTRQPFAIGGSGSTFIYGYVDAAY--KPGMSPEECRRFTTDAIALAMSRDGSSG 180

Query: 230 NRFQIATVTEKGVE 243
               + T+T  GV+
Sbjct: 181 GVIYLVTITAAGVD 194


>gi|4506205 proteasome beta 9 subunit isoform 1 proprotein [Homo
           sapiens]
          Length = 219

 Score = 39.7 bits (91), Expect = 0.003
 Identities = 43/194 (22%), Positives = 76/194 (39%), Gaps = 10/194 (5%)

Query: 52  TGTSVLGVKFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQV 111
           TGT+++ V+F+GGVV+ +D   S G     R   ++  ++       SG  AD Q +  +
Sbjct: 19  TGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADM 78

Query: 112 LGQMVIDEELLGDGHSYSP--RAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGY 169
               +   EL G      P   A  + +    Y  R  ++     +++ G+   E    Y
Sbjct: 79  AAYQL---ELHGIELEEPPLVLAAANVVRNISYKYREDLSA---HLMVAGWDQREGGQVY 132

Query: 170 VDMLGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSY 229
             + G+    P    G G+      +      +P +S  E R      + +   RD  S 
Sbjct: 133 GTLGGMLTRQPFAIGGSGSTFIYGYVDAAY--KPGMSPEECRRFTTDAIALAMSRDGSSG 190

Query: 230 NRFQIATVTEKGVE 243
               + T+T  GV+
Sbjct: 191 GVIYLVTITAAGVD 204


>gi|23110925 proteasome beta 6 subunit [Homo sapiens]
          Length = 239

 Score = 38.5 bits (88), Expect = 0.006
 Identities = 44/197 (22%), Positives = 74/197 (37%), Gaps = 15/197 (7%)

Query: 52  TGTSVLGVKFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQV 111
           TGT+++ V+F+GGVV+ AD   + GS    R   ++  +++      SG  AD Q +   
Sbjct: 33  TGTTIMAVQFDGGVVLGADSRTTTGSYIANRVTDKLTPIHDRIFCCRSGSAADTQAVADA 92

Query: 112 LGQMVIDEELLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVD 171
           +   +    +        P  +H+  +            L   ++I G+   E    Y  
Sbjct: 93  VTYQLGFHSI----ELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSV 148

Query: 172 MLGVAYEAPSLATG-----YGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDA 226
            +G      S A G     Y         RE + K+  L  T         + +   RD 
Sbjct: 149 PMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKEECLQFT------ANALALAMERDG 202

Query: 227 RSYNRFQIATVTEKGVE 243
            S    ++A + E GVE
Sbjct: 203 SSGGVIRLAAIAESGVE 219


>gi|222144262 proteasome beta 5 subunit isoform 3 [Homo sapiens]
          Length = 203

 Score = 37.7 bits (86), Expect = 0.010
 Identities = 17/65 (26%), Positives = 36/65 (55%)

Query: 50  MVTGTSVLGVKFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLK 109
           M+ GT+ L  KF  GV++AAD   + G+    + + +++ +N   +   +G  AD  + +
Sbjct: 56  MLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWE 115

Query: 110 QVLGQ 114
           ++L +
Sbjct: 116 RLLAR 120


>gi|153791216 proteasome beta 11 subunit [Homo sapiens]
          Length = 300

 Score = 33.5 bits (75), Expect = 0.20
 Identities = 51/191 (26%), Positives = 75/191 (39%), Gaps = 5/191 (2%)

Query: 53  GTSVLGVKFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVL 112
           GT+ L  +F  GV+ AAD   S GS        +++ V+   +   SG  AD     +VL
Sbjct: 49  GTTTLAFRFRHGVIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVL 108

Query: 113 GQMVIDEELLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDM 172
            Q  +    L +G   S  A  + L  AM S+   ++    T + G    G   L YV  
Sbjct: 109 -QRELRLRELREGQLPSV-ASAAKLLSAMMSQYRGLDLCVATALCGWDRSGPE-LFYVYS 165

Query: 173 LGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSYNRF 232
            G   +    + G G+  A  +L         +S  EA  L    +    +RDA S    
Sbjct: 166 DGTRLQGDIFSVGSGSPYAYGVLDRGYRYD--MSTQEAYALARCAVAHATHRDAYSGGSV 223

Query: 233 QIATVTEKGVE 243
            +  V E G E
Sbjct: 224 DLFHVRESGWE 234


>gi|4506191 proteasome beta 10 subunit proprotein [Homo sapiens]
          Length = 273

 Score = 33.5 bits (75), Expect = 0.20
 Identities = 39/201 (19%), Positives = 80/201 (39%), Gaps = 6/201 (2%)

Query: 52  TGTSVLGVKFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQV 111
           TGT++ G+ F+ GV++ AD   +  S+   ++  +I  +        +G  AD +   ++
Sbjct: 38  TGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRM 97

Query: 112 LGQMVIDEELLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVD 171
           +    ++   L  G       +   L + ++  +  +     ++++GG       L  V 
Sbjct: 98  VASK-MELHALSTGREPRVATVTRILRQTLFRYQGHVGA---SLIVGGVDLTGPQLYGVH 153

Query: 172 MLGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSYNR 231
             G     P  A G G   A  +L +    QP ++   A+ L+   +      D  S   
Sbjct: 154 PHGSYSRLPFTALGSGQDAALAVLED--RFQPNMTLEAAQGLLVEAVTAGILGDLGSGGN 211

Query: 232 FQIATVTEKGVEIEGPLSTET 252
                +T+ G ++   LS+ T
Sbjct: 212 VDACVITKTGAKLLRTLSSPT 232


>gi|207452735 epiplakin 1 [Homo sapiens]
          Length = 5090

 Score = 29.3 bits (64), Expect = 3.7
 Identities = 24/74 (32%), Positives = 37/74 (50%), Gaps = 11/74 (14%)

Query: 33  DPASALYRGPITRTQNPMVTGTS-------VLGVK---FEGGVVIAADMLGS-YGSLARF 81
           DP + LY  P++ TQ+P+V   +       +L VK   F+G  V A +++ S Y S  R 
Sbjct: 788 DPETGLYLLPLSSTQSPLVDSATQQAFQNLLLSVKYGRFQGQRVSAWELINSEYFSEGRR 847

Query: 82  RNISRIMRVNNSTM 95
           R + R  R    T+
Sbjct: 848 RQLLRRYRQREVTL 861


>gi|21704287 sialidase 4 [Homo sapiens]
          Length = 496

 Score = 28.5 bits (62), Expect = 6.3
 Identities = 29/87 (33%), Positives = 38/87 (43%), Gaps = 9/87 (10%)

Query: 132 AIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAPSLATGYGAYLA 191
           A+H   T A+   RS MNP      +     G  FL ++ +LG   EA  +ATG  A   
Sbjct: 82  ALHVLGTAALAEHRS-MNPC----PVHDAGTGTVFLFFIAVLGHTPEAVQIATGRNA--- 133

Query: 192 QPLLREVLEKQPVLSQTEARDLVERCM 218
              L  V  +   LS   ARDL E  +
Sbjct: 134 -ARLCCVASRDAGLSWGSARDLTEEAI 159


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,910,916
Number of Sequences: 37866
Number of extensions: 415948
Number of successful extensions: 897
Number of sequences better than 10.0: 14
Number of HSP's better than 10.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 882
Number of HSP's gapped (non-prelim): 15
length of query: 264
length of database: 18,247,518
effective HSP length: 100
effective length of query: 164
effective length of database: 14,460,918
effective search space: 2371590552
effective search space used: 2371590552
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.