Search of human proteins with 223555935

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|223555935 dynein, axonemal, heavy polypeptide 14 isoform 1
[Homo sapiens]
         (4515 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|223555935 dynein, axonemal, heavy polypeptide 14 isoform 1 [H...  9012   0.0  
gi|194353966 dynein, axonemal, heavy polypeptide 6 [Homo sapiens]    2159   0.0  
gi|197927452 dynein, axonemal, heavy chain 1 [Homo sapiens]           975   0.0  
gi|151301127 dynein, axonemal, heavy chain 7 [Homo sapiens]           937   0.0  
gi|24308169 dynein, axonemal, heavy chain 3 [Homo sapiens]            924   0.0  
gi|223555933 dynein, axonemal, heavy polypeptide 14 isoform 2 [H...   904   0.0  
gi|75677365 dynein heavy chain domain 3 [Homo sapiens]                893   0.0  
gi|19115954 dynein, axonemal, heavy chain 5 [Homo sapiens]            776   0.0  
gi|198442844 dynein, axonemal, heavy chain 10 [Homo sapiens]          764   0.0  
gi|126012497 dynein, axonemal, heavy polypeptide 8 [Homo sapiens]     760   0.0  
gi|114155133 dynein, axonemal, heavy chain 9 isoform 2 [Homo sap...   754   0.0  
gi|51479173 dynein, axonemal, heavy chain 11 [Homo sapiens]           743   0.0  
gi|239756957 PREDICTED: dynein, axonemal, heavy chain 17 [Homo s...   718   0.0  
gi|239751459 PREDICTED: dynein, axonemal, heavy chain 17 [Homo s...   701   0.0  
gi|239745966 PREDICTED: dynein, axonemal, heavy chain 17 [Homo s...   701   0.0  
gi|194440727 dynein heavy chain domain 2 isoform 1 [Homo sapiens]     690   0.0  
gi|33350932 cytoplasmic dynein 1 heavy chain 1 [Homo sapiens]         539   e-152
gi|122937398 dynein, cytoplasmic 2, heavy chain 1 [Homo sapiens]      533   e-150
gi|149944493 dynein, axonemal, heavy polypeptide 14 isoform 3 [H...   439   e-122
gi|114155135 dynein, axonemal, heavy chain 9 isoform 1 [Homo sap...   292   4e-78
gi|222144249 dynein heavy chain domain 1 isoform 1 [Homo sapiens]     171   1e-41
gi|24415404 MDN1, midasin homolog [Homo sapiens]                       44   0.004
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    44   0.005
gi|38045919 huntingtin interacting protein 1 [Homo sapiens]            43   0.008
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    42   0.014
gi|114155142 nuclear pore complex-associated protein TPR [Homo s...    42   0.014
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]    42   0.018
gi|118498356 kinectin 1 isoform a [Homo sapiens]                       40   0.040
gi|33620775 kinectin 1 isoform a [Homo sapiens]                        40   0.040
gi|222144247 dynein heavy chain domain 1 isoform 2 [Homo sapiens]      40   0.040

>gi|223555935 dynein, axonemal, heavy polypeptide 14 isoform 1 [Homo
            sapiens]
          Length = 4515

 Score = 9012 bits (23384), Expect = 0.0
 Identities = 4515/4515 (100%), Positives = 4515/4515 (100%)

Query: 1    METFIPIDLTTENQEMDKEETKTKPRLLRYEEKKYEDVKPLETQPAEIAEKETLEYKTVR 60
            METFIPIDLTTENQEMDKEETKTKPRLLRYEEKKYEDVKPLETQPAEIAEKETLEYKTVR
Sbjct: 1    METFIPIDLTTENQEMDKEETKTKPRLLRYEEKKYEDVKPLETQPAEIAEKETLEYKTVR 60

Query: 61   TFSESLKSEKTEDYLRESIIQQHMVSPEPASLKEKGKSRRKKDQTHACPNVRKARPVSYD 120
            TFSESLKSEKTEDYLRESIIQQHMVSPEPASLKEKGKSRRKKDQTHACPNVRKARPVSYD
Sbjct: 61   TFSESLKSEKTEDYLRESIIQQHMVSPEPASLKEKGKSRRKKDQTHACPNVRKARPVSYD 120

Query: 121  RTEPKDDDVIRNIIRLREKLGWQTILPQHSLKYGSSKIAIQKITLKKPLEDDGEFVYCLP 180
            RTEPKDDDVIRNIIRLREKLGWQTILPQHSLKYGSSKIAIQKITLKKPLEDDGEFVYCLP
Sbjct: 121  RTEPKDDDVIRNIIRLREKLGWQTILPQHSLKYGSSKIAIQKITLKKPLEDDGEFVYCLP 180

Query: 181  RKSPKSLYNPYDLQVVSAHTAKHCKEFWVITASFISKVINIVGSVKEVELIPTLEWLSER 240
            RKSPKSLYNPYDLQVVSAHTAKHCKEFWVITASFISKVINIVGSVKEVELIPTLEWLSER
Sbjct: 181  RKSPKSLYNPYDLQVVSAHTAKHCKEFWVITASFISKVINIVGSVKEVELIPTLEWLSER 240

Query: 241  RHYYLLRQFKIFSDFRMNKAFVTWKLNVKRIKTEKSRSFLYHHLFLADDLFQTCLVYIRG 300
            RHYYLLRQFKIFSDFRMNKAFVTWKLNVKRIKTEKSRSFLYHHLFLADDLFQTCLVYIRG
Sbjct: 241  RHYYLLRQFKIFSDFRMNKAFVTWKLNVKRIKTEKSRSFLYHHLFLADDLFQTCLVYIRG 300

Query: 301  LCEDAINLKNYNDHENNLSAICLVKLDSSRTYSLDEFCEEQLQQATQALKQLEDIRNKAI 360
            LCEDAINLKNYNDHENNLSAICLVKLDSSRTYSLDEFCEEQLQQATQALKQLEDIRNKAI
Sbjct: 301  LCEDAINLKNYNDHENNLSAICLVKLDSSRTYSLDEFCEEQLQQATQALKQLEDIRNKAI 360

Query: 361  SEMKSTFLKVAEKNEIKEYFESKLSEDDTTHFKLPKYRRLLETFFKFVMLVDYIFQELIR 420
            SEMKSTFLKVAEKNEIKEYFESKLSEDDTTHFKLPKYRRLLETFFKFVMLVDYIFQELIR
Sbjct: 361  SEMKSTFLKVAEKNEIKEYFESKLSEDDTTHFKLPKYRRLLETFFKFVMLVDYIFQELIR 420

Query: 421  QLMNTAVTLLLELFNGSAGMPFSVEKKNENLIRTFKDNSFPTGKTTNDCEELVDNSKLHA 480
            QLMNTAVTLLLELFNGSAGMPFSVEKKNENLIRTFKDNSFPTGKTTNDCEELVDNSKLHA
Sbjct: 421  QLMNTAVTLLLELFNGSAGMPFSVEKKNENLIRTFKDNSFPTGKTTNDCEELVDNSKLHA 480

Query: 481  ISVQKSEVKTDTDINEILNSVEVGKDLRKTYAPIFEVNLCLRIPAESDSSENSKENFHES 540
            ISVQKSEVKTDTDINEILNSVEVGKDLRKTYAPIFEVNLCLRIPAESDSSENSKENFHES
Sbjct: 481  ISVQKSEVKTDTDINEILNSVEVGKDLRKTYAPIFEVNLCLRIPAESDSSENSKENFHES 540

Query: 541  DQCPEECVMFEDEMSENKDNCVKKHSSEELLPKAKKSKEISYNLEDIISDTEIETEFENK 600
            DQCPEECVMFEDEMSENKDNCVKKHSSEELLPKAKKSKEISYNLEDIISDTEIETEFENK
Sbjct: 541  DQCPEECVMFEDEMSENKDNCVKKHSSEELLPKAKKSKEISYNLEDIISDTEIETEFENK 600

Query: 601  YMYYEFPEFPTNLFIDPNRLEFSVKIQNMLTNMEKCITTITPLCQDPQLSIFIDLVSIMD 660
            YMYYEFPEFPTNLFIDPNRLEFSVKIQNMLTNMEKCITTITPLCQDPQLSIFIDLVSIMD
Sbjct: 601  YMYYEFPEFPTNLFIDPNRLEFSVKIQNMLTNMEKCITTITPLCQDPQLSIFIDLVSIMD 660

Query: 661  LPNKTGSIIHYKEQTRWPDCHILFETDPAYQNIIVNLLTIIGNSMGLVNAYSHKFIKYCT 720
            LPNKTGSIIHYKEQTRWPDCHILFETDPAYQNIIVNLLTIIGNSMGLVNAYSHKFIKYCT
Sbjct: 661  LPNKTGSIIHYKEQTRWPDCHILFETDPAYQNIIVNLLTIIGNSMGLVNAYSHKFIKYCT 720

Query: 721  MTEKAKIMSMKISSMGELTSKEFEAILNRFRNYFRHIVNMAIEKRIGIFNVVSLDYQSEC 780
            MTEKAKIMSMKISSMGELTSKEFEAILNRFRNYFRHIVNMAIEKRIGIFNVVSLDYQSEC
Sbjct: 721  MTEKAKIMSMKISSMGELTSKEFEAILNRFRNYFRHIVNMAIEKRIGIFNVVSLDYQSEC 780

Query: 781  LLYIDNVIHMSHTLIQSVIEKKNKNLLEVVESSLQQLECDPTEIEEFLEHFIFLNAISSK 840
            LLYIDNVIHMSHTLIQSVIEKKNKNLLEVVESSLQQLECDPTEIEEFLEHFIFLNAISSK
Sbjct: 781  LLYIDNVIHMSHTLIQSVIEKKNKNLLEVVESSLQQLECDPTEIEEFLEHFIFLNAISSK 840

Query: 841  ISKLEKEFLTMSQLYSVAKHHQIHISEEQIAIFQVLLLKFSQLKSSMKLSKINKDTAITK 900
            ISKLEKEFLTMSQLYSVAKHHQIHISEEQIAIFQVLLLKFSQLKSSMKLSKINKDTAITK
Sbjct: 841  ISKLEKEFLTMSQLYSVAKHHQIHISEEQIAIFQVLLLKFSQLKSSMKLSKINKDTAITK 900

Query: 901  FRDNLEACISGLHVDVGNLKAKIRTPLLLCAGTQVSTAMEMIQTLSGEAASLTNKAKAYS 960
            FRDNLEACISGLHVDVGNLKAKIRTPLLLCAGTQVSTAMEMIQTLSGEAASLTNKAKAYS
Sbjct: 901  FRDNLEACISGLHVDVGNLKAKIRTPLLLCAGTQVSTAMEMIQTLSGEAASLTNKAKAYS 960

Query: 961  HYQDCFSDSQSHMHSVNVEEITQIVLSEISDIEGDLTLRKKLWEAQEEWKRASWEWRNSS 1020
            HYQDCFSDSQSHMHSVNVEEITQIVLSEISDIEGDLTLRKKLWEAQEEWKRASWEWRNSS
Sbjct: 961  HYQDCFSDSQSHMHSVNVEEITQIVLSEISDIEGDLTLRKKLWEAQEEWKRASWEWRNSS 1020

Query: 1021 LQSIDVESVQRNVSKLMHIISVLEKGLPKSDMVTHLKQVVTEFKQELPIIIALGNPCLKP 1080
            LQSIDVESVQRNVSKLMHIISVLEKGLPKSDMVTHLKQVVTEFKQELPIIIALGNPCLKP
Sbjct: 1021 LQSIDVESVQRNVSKLMHIISVLEKGLPKSDMVTHLKQVVTEFKQELPIIIALGNPCLKP 1080

Query: 1081 RHWEALQEIIGKSVPLDKNCKVENLLALKMFQYENEINDMSTSATNEAALEKMLFKIIDF 1140
            RHWEALQEIIGKSVPLDKNCKVENLLALKMFQYENEINDMSTSATNEAALEKMLFKIIDF
Sbjct: 1081 RHWEALQEIIGKSVPLDKNCKVENLLALKMFQYENEINDMSTSATNEAALEKMLFKIIDF 1140

Query: 1141 WNTTPLPLILHHTEIYSIFIIPSIDDISAQLEESQVILATIKGSPHIGPIKDLVNEWDQN 1200
            WNTTPLPLILHHTEIYSIFIIPSIDDISAQLEESQVILATIKGSPHIGPIKDLVNEWDQN
Sbjct: 1141 WNTTPLPLILHHTEIYSIFIIPSIDDISAQLEESQVILATIKGSPHIGPIKDLVNEWDQN 1200

Query: 1201 LTLFSYTLEEWMNCQRNWLYLEPVFHSSEIRRQLPAETELFSQVISMWKKIMSKIQNKQN 1260
            LTLFSYTLEEWMNCQRNWLYLEPVFHSSEIRRQLPAETELFSQVISMWKKIMSKIQNKQN
Sbjct: 1201 LTLFSYTLEEWMNCQRNWLYLEPVFHSSEIRRQLPAETELFSQVISMWKKIMSKIQNKQN 1260

Query: 1261 ALQITTSAGVLEILQNCNIHLEHIKKSLEDYLEVKRLIFPRFYFLSNAELLDILADSRNP 1320
            ALQITTSAGVLEILQNCNIHLEHIKKSLEDYLEVKRLIFPRFYFLSNAELLDILADSRNP
Sbjct: 1261 ALQITTSAGVLEILQNCNIHLEHIKKSLEDYLEVKRLIFPRFYFLSNAELLDILADSRNP 1320

Query: 1321 ESVQPHLVKCFENIKQLLIWKQDIGPPAVKMLISAEGEGLVLPKKIRVRSAVEQWLVNVE 1380
            ESVQPHLVKCFENIKQLLIWKQDIGPPAVKMLISAEGEGLVLPKKIRVRSAVEQWLVNVE
Sbjct: 1321 ESVQPHLVKCFENIKQLLIWKQDIGPPAVKMLISAEGEGLVLPKKIRVRSAVEQWLVNVE 1380

Query: 1381 KSMFDVLKKERYIYNIILLFQSQIMFYNDCVKSFVSSYSREKLEKVHAGLMCHLEEVADL 1440
            KSMFDVLKKERYIYNIILLFQSQIMFYNDCVKSFVSSYSREKLEKVHAGLMCHLEEVADL
Sbjct: 1381 KSMFDVLKKERYIYNIILLFQSQIMFYNDCVKSFVSSYSREKLEKVHAGLMCHLEEVADL 1440

Query: 1441 VVLDTSNSRTKAILGALLILYVHCRDIVINLLLKNIFNAEDFEWTRHLQYKWNEKQKLCY 1500
            VVLDTSNSRTKAILGALLILYVHCRDIVINLLLKNIFNAEDFEWTRHLQYKWNEKQKLCY
Sbjct: 1441 VVLDTSNSRTKAILGALLILYVHCRDIVINLLLKNIFNAEDFEWTRHLQYKWNEKQKLCY 1500

Query: 1501 VSQGNASFTYGYEYLGCTSRLVITPLTDRCWLTLMEALHLNLGGCPAGPAGTGKTETVKD 1560
            VSQGNASFTYGYEYLGCTSRLVITPLTDRCWLTLMEALHLNLGGCPAGPAGTGKTETVKD
Sbjct: 1501 VSQGNASFTYGYEYLGCTSRLVITPLTDRCWLTLMEALHLNLGGCPAGPAGTGKTETVKD 1560

Query: 1561 LAKSLGKHCVVFNCFEDLDYKIVRKFFFGLVQSGAWSCFDEFNLIDLEVLSVIASQILTI 1620
            LAKSLGKHCVVFNCFEDLDYKIVRKFFFGLVQSGAWSCFDEFNLIDLEVLSVIASQILTI
Sbjct: 1561 LAKSLGKHCVVFNCFEDLDYKIVRKFFFGLVQSGAWSCFDEFNLIDLEVLSVIASQILTI 1620

Query: 1621 KAAKDNYSARFVLEGKEIRINMSCAVFITMNPRYGGGVELPDNLKSLFRPVAMMVPHYQM 1680
            KAAKDNYSARFVLEGKEIRINMSCAVFITMNPRYGGGVELPDNLKSLFRPVAMMVPHYQM
Sbjct: 1621 KAAKDNYSARFVLEGKEIRINMSCAVFITMNPRYGGGVELPDNLKSLFRPVAMMVPHYQM 1680

Query: 1681 IAEIILFSFGFKSANSLSGKLTNLYELARKQLSQQDHYNFGLRSLKIVLIMAGTKKREFK 1740
            IAEIILFSFGFKSANSLSGKLTNLYELARKQLSQQDHYNFGLRSLKIVLIMAGTKKREFK
Sbjct: 1681 IAEIILFSFGFKSANSLSGKLTNLYELARKQLSQQDHYNFGLRSLKIVLIMAGTKKREFK 1740

Query: 1741 CLSEADETLIVIEAIREASLPKCPPEDVPLFENIIGDIFPEVTVLKVNQLALEKVIYTAT 1800
            CLSEADETLIVIEAIREASLPKCPPEDVPLFENIIGDIFPEVTVLKVNQLALEKVIYTAT
Sbjct: 1741 CLSEADETLIVIEAIREASLPKCPPEDVPLFENIIGDIFPEVTVLKVNQLALEKVIYTAT 1800

Query: 1801 QQLGLQNWSSQKEKIIQFYNQLQVCVGVMLVGPTGGGKTTVRRILEKALTLLPIADFLSV 1860
            QQLGLQNWSSQKEKIIQFYNQLQVCVGVMLVGPTGGGKTTVRRILEKALTLLPIADFLSV
Sbjct: 1801 QQLGLQNWSSQKEKIIQFYNQLQVCVGVMLVGPTGGGKTTVRRILEKALTLLPIADFLSV 1860

Query: 1861 AERKSASKISERKGKVDICVLNPKCVTLSELYGQLDPNTMEWTDGLLSATIRSYVYFNTP 1920
            AERKSASKISERKGKVDICVLNPKCVTLSELYGQLDPNTMEWTDGLLSATIRSYVYFNTP
Sbjct: 1861 AERKSASKISERKGKVDICVLNPKCVTLSELYGQLDPNTMEWTDGLLSATIRSYVYFNTP 1920

Query: 1921 KNTKKDIDLRLKSRISDLSNVFKLDSSDTTETDDNIFEEIEKVVKIPENHNFDWQWIILD 1980
            KNTKKDIDLRLKSRISDLSNVFKLDSSDTTETDDNIFEEIEKVVKIPENHNFDWQWIILD
Sbjct: 1921 KNTKKDIDLRLKSRISDLSNVFKLDSSDTTETDDNIFEEIEKVVKIPENHNFDWQWIILD 1980

Query: 1981 GPVDTFWVENLNSVLDDTRTLCLANSERIALTNKIRVIFEVDNLSQASPATVSRCAMVYM 2040
            GPVDTFWVENLNSVLDDTRTLCLANSERIALTNKIRVIFEVDNLSQASPATVSRCAMVYM
Sbjct: 1981 GPVDTFWVENLNSVLDDTRTLCLANSERIALTNKIRVIFEVDNLSQASPATVSRCAMVYM 2040

Query: 2041 DPVDLGWEPYVKSWLLKTSKIISQSGVDCLEFMIKNSVTDGLQFIRNRQKFQPYPMEDIT 2100
            DPVDLGWEPYVKSWLLKTSKIISQSGVDCLEFMIKNSVTDGLQFIRNRQKFQPYPMEDIT
Sbjct: 2041 DPVDLGWEPYVKSWLLKTSKIISQSGVDCLEFMIKNSVTDGLQFIRNRQKFQPYPMEDIT 2100

Query: 2101 VVITLCRILDAFFDFMGKNGGFEQSDDLNDTSSKEANSQRESVTFKDIEKRDENTWYPEK 2160
            VVITLCRILDAFFDFMGKNGGFEQSDDLNDTSSKEANSQRESVTFKDIEKRDENTWYPEK
Sbjct: 2101 VVITLCRILDAFFDFMGKNGGFEQSDDLNDTSSKEANSQRESVTFKDIEKRDENTWYPEK 2160

Query: 2161 NPDKLTKIIQKLFVFAFTWAFGGALNREDEHRENIPFCPSLEPDSLAKVTYDFDKLVHEL 2220
            NPDKLTKIIQKLFVFAFTWAFGGALNREDEHRENIPFCPSLEPDSLAKVTYDFDKLVHEL
Sbjct: 2161 NPDKLTKIIQKLFVFAFTWAFGGALNREDEHRENIPFCPSLEPDSLAKVTYDFDKLVHEL 2220

Query: 2221 FGNSSQVGWKHWGQSQGRRRKGNCINLPTGECSIFGYFVDIEQCEFIPWSDLVPNDQTLI 2280
            FGNSSQVGWKHWGQSQGRRRKGNCINLPTGECSIFGYFVDIEQCEFIPWSDLVPNDQTLI
Sbjct: 2221 FGNSSQVGWKHWGQSQGRRRKGNCINLPTGECSIFGYFVDIEQCEFIPWSDLVPNDQTLI 2280

Query: 2281 QRGTSLLTNLQRSGGNFLKITECGECINYTATRDTTCLSFLMSLLLKNSCPVLLTGESGV 2340
            QRGTSLLTNLQRSGGNFLKITECGECINYTATRDTTCLSFLMSLLLKNSCPVLLTGESGV
Sbjct: 2281 QRGTSLLTNLQRSGGNFLKITECGECINYTATRDTTCLSFLMSLLLKNSCPVLLTGESGV 2340

Query: 2341 GKTAAINQMLEKLEGPGAFDIKHGSILGDTLLYSEIKKSSSLKQNITILIPETHKTATGS 2400
            GKTAAINQMLEKLEGPGAFDIKHGSILGDTLLYSEIKKSSSLKQNITILIPETHKTATGS
Sbjct: 2341 GKTAAINQMLEKLEGPGAFDIKHGSILGDTLLYSEIKKSSSLKQNITILIPETHKTATGS 2400

Query: 2401 SDNPTKKPEVRTNKKLLKNNDHKGVVVSTINFSTNVTAAKTKEMILKKLIRRTKDTLGAP 2460
            SDNPTKKPEVRTNKKLLKNNDHKGVVVSTINFSTNVTAAKTKEMILKKLIRRTKDTLGAP
Sbjct: 2401 SDNPTKKPEVRTNKKLLKNNDHKGVVVSTINFSTNVTAAKTKEMILKKLIRRTKDTLGAP 2460

Query: 2461 KNNRILIFIDDMNMPVSDMYGAQPPLELIRQLLDLGGVYDTEKNTWKNIQDLSIVAACVP 2520
            KNNRILIFIDDMNMPVSDMYGAQPPLELIRQLLDLGGVYDTEKNTWKNIQDLSIVAACVP
Sbjct: 2461 KNNRILIFIDDMNMPVSDMYGAQPPLELIRQLLDLGGVYDTEKNTWKNIQDLSIVAACVP 2520

Query: 2521 VVNDISPRLLKHFSMLVLPHPSQDILCTIFQAHLGIYFSINNFTPEVQKSKDQIISCSLA 2580
            VVNDISPRLLKHFSMLVLPHPSQDILCTIFQAHLGIYFSINNFTPEVQKSKDQIISCSLA
Sbjct: 2521 VVNDISPRLLKHFSMLVLPHPSQDILCTIFQAHLGIYFSINNFTPEVQKSKDQIISCSLA 2580

Query: 2581 IYHQVRQNMLPTPTKCHYMFNLRDMFKLLLGLLQADRTVVNSKEMAALLFVHEATRVFHD 2640
            IYHQVRQNMLPTPTKCHYMFNLRDMFKLLLGLLQADRTVVNSKEMAALLFVHEATRVFHD
Sbjct: 2581 IYHQVRQNMLPTPTKCHYMFNLRDMFKLLLGLLQADRTVVNSKEMAALLFVHEATRVFHD 2640

Query: 2641 RLIDFTDKSLFYRLLSRELENCFQIGIDGCGKKTCATLACYLTDNKLYRVPISHKCAYIE 2700
            RLIDFTDKSLFYRLLSRELENCFQIGIDGCGKKTCATLACYLTDNKLYRVPISHKCAYIE
Sbjct: 2641 RLIDFTDKSLFYRLLSRELENCFQIGIDGCGKKTCATLACYLTDNKLYRVPISHKCAYIE 2700

Query: 2701 FKEVFKKVFIHAGLKGKPTVLMVPNLNIEQDSFLEDLNYIISSGRIPDLFENVELDSIAM 2760
            FKEVFKKVFIHAGLKGKPTVLMVPNLNIEQDSFLEDLNYIISSGRIPDLFENVELDSIAM
Sbjct: 2701 FKEVFKKVFIHAGLKGKPTVLMVPNLNIEQDSFLEDLNYIISSGRIPDLFENVELDSIAM 2760

Query: 2761 KIRYLTEQSGHMDNRQSLLSFFQKRIYKNLHIFVIMSPEGPSFRQNCRVYPSMISSCTID 2820
            KIRYLTEQSGHMDNRQSLLSFFQKRIYKNLHIFVIMSPEGPSFRQNCRVYPSMISSCTID
Sbjct: 2761 KIRYLTEQSGHMDNRQSLLSFFQKRIYKNLHIFVIMSPEGPSFRQNCRVYPSMISSCTID 2820

Query: 2821 WYERWPEEALLIVANSFLKEKVNFENRENLKEKLAPTCVQIHKSMKDLNRKYFEETGRFY 2880
            WYERWPEEALLIVANSFLKEKVNFENRENLKEKLAPTCVQIHKSMKDLNRKYFEETGRFY
Sbjct: 2821 WYERWPEEALLIVANSFLKEKVNFENRENLKEKLAPTCVQIHKSMKDLNRKYFEETGRFY 2880

Query: 2881 YTTPNSYLQFMETFAHILRAREEEMQTKRDRFHMGLSTILEATTLVTEMQEELLILGPQV 2940
            YTTPNSYLQFMETFAHILRAREEEMQTKRDRFHMGLSTILEATTLVTEMQEELLILGPQV
Sbjct: 2881 YTTPNSYLQFMETFAHILRAREEEMQTKRDRFHMGLSTILEATTLVTEMQEELLILGPQV 2940

Query: 2941 EQKTKETETLMEKLRKDSQVVEKVQMLVKQDEEIVAEEVRIVEDYAQKTANELKSVLPAF 3000
            EQKTKETETLMEKLRKDSQVVEKVQMLVKQDEEIVAEEVRIVEDYAQKTANELKSVLPAF
Sbjct: 2941 EQKTKETETLMEKLRKDSQVVEKVQMLVKQDEEIVAEEVRIVEDYAQKTANELKSVLPAF 3000

Query: 3001 DKAIVALNALDKADVAELRVYTRPPFLVLTVMNAVCILLQKKPNWATAKLLLSETGFLKK 3060
            DKAIVALNALDKADVAELRVYTRPPFLVLTVMNAVCILLQKKPNWATAKLLLSETGFLKK
Sbjct: 3001 DKAIVALNALDKADVAELRVYTRPPFLVLTVMNAVCILLQKKPNWATAKLLLSETGFLKK 3060

Query: 3061 LINLDKDSIPDKVFVKLKKIVTLPDFNPHKISLVSVACCSLCQWVIALNNYHEVQKVVGP 3120
            LINLDKDSIPDKVFVKLKKIVTLPDFNPHKISLVSVACCSLCQWVIALNNYHEVQKVVGP
Sbjct: 3061 LINLDKDSIPDKVFVKLKKIVTLPDFNPHKISLVSVACCSLCQWVIALNNYHEVQKVVGP 3120

Query: 3121 KQIQVAEAQNVLKIARQRLAEKQRGLQLVEEHLLFLQAAYKDTVAEKQLLANRKTMASRR 3180
            KQIQVAEAQNVLKIARQRLAEKQRGLQLVEEHLLFLQAAYKDTVAEKQLLANRKTMASRR
Sbjct: 3121 KQIQVAEAQNVLKIARQRLAEKQRGLQLVEEHLLFLQAAYKDTVAEKQLLANRKTMASRR 3180

Query: 3181 FQCASVLLTVLEDEKTRWQETINQIDNKLEGILGDILLSAACIVYSGILTPEFRQLIVNK 3240
            FQCASVLLTVLEDEKTRWQETINQIDNKLEGILGDILLSAACIVYSGILTPEFRQLIVNK
Sbjct: 3181 FQCASVLLTVLEDEKTRWQETINQIDNKLEGILGDILLSAACIVYSGILTPEFRQLIVNK 3240

Query: 3241 WETFCIENGISLSSKFSLIKVMAQKYEISRWHNQGLPHGQYSVENAILIKNGQQWPLLID 3300
            WETFCIENGISLSSKFSLIKVMAQKYEISRWHNQGLPHGQYSVENAILIKNGQQWPLLID
Sbjct: 3241 WETFCIENGISLSSKFSLIKVMAQKYEISRWHNQGLPHGQYSVENAILIKNGQQWPLLID 3300

Query: 3301 PHRQAHKWIRQMEGSRLQKLSIEDSNYTKKIENAMKTGGSVLLQNLLETLAPGLKAILKK 3360
            PHRQAHKWIRQMEGSRLQKLSIEDSNYTKKIENAMKTGGSVLLQNLLETLAPGLKAILKK
Sbjct: 3301 PHRQAHKWIRQMEGSRLQKLSIEDSNYTKKIENAMKTGGSVLLQNLLETLAPGLKAILKK 3360

Query: 3361 DIYQKKGHYFIRVGDAEFEYNSNFRLYLSTEIDNPHFLPSVYNFVTMINFTVTFQGLQDQ 3420
            DIYQKKGHYFIRVGDAEFEYNSNFRLYLSTEIDNPHFLPSVYNFVTMINFTVTFQGLQDQ
Sbjct: 3361 DIYQKKGHYFIRVGDAEFEYNSNFRLYLSTEIDNPHFLPSVYNFVTMINFTVTFQGLQDQ 3420

Query: 3421 LLSTVVTHEVPHLEDQRSKLLESISLDAITLEELEEKTLNLLQKALGSILDDDKIVDTLR 3480
            LLSTVVTHEVPHLEDQRSKLLESISLDAITLEELEEKTLNLLQKALGSILDDDKIVDTLR
Sbjct: 3421 LLSTVVTHEVPHLEDQRSKLLESISLDAITLEELEEKTLNLLQKALGSILDDDKIVDTLR 3480

Query: 3481 KSKMTSNEISKRIEATKKAESEIQAIRKNYLPIATRGALLYFLVADLTQINYMYQFSLDW 3540
            KSKMTSNEISKRIEATKKAESEIQAIRKNYLPIATRGALLYFLVADLTQINYMYQFSLDW
Sbjct: 3481 KSKMTSNEISKRIEATKKAESEIQAIRKNYLPIATRGALLYFLVADLTQINYMYQFSLDW 3540

Query: 3541 FHQVFVSSVVSKSKEQEHSFKREKVSPKEVHEFISISKEPNLENEKNLLDKHIKSAIDML 3600
            FHQVFVSSVVSKSKEQEHSFKREKVSPKEVHEFISISKEPNLENEKNLLDKHIKSAIDML
Sbjct: 3541 FHQVFVSSVVSKSKEQEHSFKREKVSPKEVHEFISISKEPNLENEKNLLDKHIKSAIDML 3600

Query: 3601 TKSIFKVVSSALFNEDKLCFSFRLCTVIMQNNANGNLIQDDIGFLPEEEWNIFLYSGILI 3660
            TKSIFKVVSSALFNEDKLCFSFRLCTVIMQNNANGNLIQDDIGFLPEEEWNIFLYSGILI
Sbjct: 3601 TKSIFKVVSSALFNEDKLCFSFRLCTVIMQNNANGNLIQDDIGFLPEEEWNIFLYSGILI 3660

Query: 3661 NIKSALSQSRLTSTFEIGESQHLQWLSDSRWRQCQYVSTHLEPFSLLCKSLLSNVSQWDT 3720
            NIKSALSQSRLTSTFEIGESQHLQWLSDSRWRQCQYVSTHLEPFSLLCKSLLSNVSQWDT
Sbjct: 3661 NIKSALSQSRLTSTFEIGESQHLQWLSDSRWRQCQYVSTHLEPFSLLCKSLLSNVSQWDT 3720

Query: 3721 FKNSKAVYSLISTPFSSENASLEENTKPPEETELLNENKETCNPINFPWEKLTSFQRLIL 3780
            FKNSKAVYSLISTPFSSENASLEENTKPPEETELLNENKETCNPINFPWEKLTSFQRLIL
Sbjct: 3721 FKNSKAVYSLISTPFSSENASLEENTKPPEETELLNENKETCNPINFPWEKLTSFQRLIL 3780

Query: 3781 VKVLRPESLNNSVRKFITEKMGNKYLQRTGVNLKDAYKGSNARTPLILIQTHGIDLTNIL 3840
            VKVLRPESLNNSVRKFITEKMGNKYLQRTGVNLKDAYKGSNARTPLILIQTHGIDLTNIL
Sbjct: 3781 VKVLRPESLNNSVRKFITEKMGNKYLQRTGVNLKDAYKGSNARTPLILIQTHGIDLTNIL 3840

Query: 3841 LRFAQELKGTTHHVTIISLGRDQAAKAEDLILKALTKTQQWVFLQNCHLATSFMPRLCTI 3900
            LRFAQELKGTTHHVTIISLGRDQAAKAEDLILKALTKTQQWVFLQNCHLATSFMPRLCTI
Sbjct: 3841 LRFAQELKGTTHHVTIISLGRDQAAKAEDLILKALTKTQQWVFLQNCHLATSFMPRLCTI 3900

Query: 3901 VESFNSPNVTIDPEFRLWLSSKSYSSFPIPVLKKGLKIAVESPQGLKSNLLQTFGCTGSG 3960
            VESFNSPNVTIDPEFRLWLSSKSYSSFPIPVLKKGLKIAVESPQGLKSNLLQTFGCTGSG
Sbjct: 3901 VESFNSPNVTIDPEFRLWLSSKSYSSFPIPVLKKGLKIAVESPQGLKSNLLQTFGCTGSG 3960

Query: 3961 EVTEEIFENPDCGQWWKKLLFSLCFFNAVINERKNYGILGWNIAYKFNSSDLGVAIKVLE 4020
            EVTEEIFENPDCGQWWKKLLFSLCFFNAVINERKNYGILGWNIAYKFNSSDLGVAIKVLE
Sbjct: 3961 EVTEEIFENPDCGQWWKKLLFSLCFFNAVINERKNYGILGWNIAYKFNSSDLGVAIKVLE 4020

Query: 4021 NSLRGQPSISWQALRYLIGEVIYGGRVIDNWDKRCLKTLLYKFCNPEVLKDDFSFSRSAS 4080
            NSLRGQPSISWQALRYLIGEVIYGGRVIDNWDKRCLKTLLYKFCNPEVLKDDFSFSRSAS
Sbjct: 4021 NSLRGQPSISWQALRYLIGEVIYGGRVIDNWDKRCLKTLLYKFCNPEVLKDDFSFSRSAS 4080

Query: 4081 IKDYIHIIQSLPDDDLPEVLGIHPEAIRSCWETQGEKFIENLIAMQPKTTTANLMIRPEQ 4140
            IKDYIHIIQSLPDDDLPEVLGIHPEAIRSCWETQGEKFIENLIAMQPKTTTANLMIRPEQ
Sbjct: 4081 IKDYIHIIQSLPDDDLPEVLGIHPEAIRSCWETQGEKFIENLIAMQPKTTTANLMIRPEQ 4140

Query: 4141 SKDELVMEILSDLLKRLPLTVEKEEIAVGTPSTLKSMMSSSIWESLSKNLKDHDPLIHCV 4200
            SKDELVMEILSDLLKRLPLTVEKEEIAVGTPSTLKSMMSSSIWESLSKNLKDHDPLIHCV
Sbjct: 4141 SKDELVMEILSDLLKRLPLTVEKEEIAVGTPSTLKSMMSSSIWESLSKNLKDHDPLIHCV 4200

Query: 4201 LLTFLKQEIKRFDKLLFVIHKSLKDLQLAIKGEIILTQELEEIFNSFLNMRVPTLWQKHA 4260
            LLTFLKQEIKRFDKLLFVIHKSLKDLQLAIKGEIILTQELEEIFNSFLNMRVPTLWQKHA
Sbjct: 4201 LLTFLKQEIKRFDKLLFVIHKSLKDLQLAIKGEIILTQELEEIFNSFLNMRVPTLWQKHA 4260

Query: 4261 YRSCKPLSSWIDDLIQRLNFFNTWAKVAYTAIQRRYMRFVTVWKQSIPSTSQKCKHPEDS 4320
            YRSCKPLSSWIDDLIQRLNFFNTWAKVAYTAIQRRYMRFVTVWKQSIPSTSQKCKHPEDS
Sbjct: 4261 YRSCKPLSSWIDDLIQRLNFFNTWAKVAYTAIQRRYMRFVTVWKQSIPSTSQKCKHPEDS 4320

Query: 4321 ENNFFEGFPSRYWLPAFFFPQAFLAAVLQDYGRSRGIAVDALTFTHHVISNTTDKDEKFS 4380
            ENNFFEGFPSRYWLPAFFFPQAFLAAVLQDYGRSRGIAVDALTFTHHVISNTTDKDEKFS
Sbjct: 4321 ENNFFEGFPSRYWLPAFFFPQAFLAAVLQDYGRSRGIAVDALTFTHHVISNTTDKDEKFS 4380

Query: 4381 VFMPKKLNIVRRAFKGSASSHTGVYIFGLFIEGARWNREQKILEDSLPLEMCCDFPDIYF 4440
            VFMPKKLNIVRRAFKGSASSHTGVYIFGLFIEGARWNREQKILEDSLPLEMCCDFPDIYF
Sbjct: 4381 VFMPKKLNIVRRAFKGSASSHTGVYIFGLFIEGARWNREQKILEDSLPLEMCCDFPDIYF 4440

Query: 4441 LPTKISTKTPNASNQTDSELYAFECPVYQTPERSRILATTGLPTNFLTSVYLSTKKPPSH 4500
            LPTKISTKTPNASNQTDSELYAFECPVYQTPERSRILATTGLPTNFLTSVYLSTKKPPSH
Sbjct: 4441 LPTKISTKTPNASNQTDSELYAFECPVYQTPERSRILATTGLPTNFLTSVYLSTKKPPSH 4500

Query: 4501 WITMRVALLCEKNEK 4515
            WITMRVALLCEKNEK
Sbjct: 4501 WITMRVALLCEKNEK 4515


>gi|194353966 dynein, axonemal, heavy polypeptide 6 [Homo sapiens]
          Length = 4158

 Score = 2159 bits (5594), Expect = 0.0
 Identities = 1369/4074 (33%), Positives = 2105/4074 (51%), Gaps = 592/4074 (14%)

Query: 607  PEFPTNLFIDPNRLEFSVKIQNMLTNMEKCITTITPLCQDPQLSI-------FIDLVSIM 659
            P F T L +    L F   +++ L  +   +      CQ+  LS+       + D  +  
Sbjct: 511  PMFLTELMLTVQSLLFEPSLEDFLDGILGAVNH----CQNTVLSVPNLVPDSYFDAFTSP 566

Query: 660  DLPNKTGSIIHYKEQTRWPDCHILFETDPAYQNIIVNLLTIIGNSMGLVNAYSHKFIKYC 719
             + NK    +  K     P    +FE D  +  II  +   I  +      Y+  F K+ 
Sbjct: 567  YINNK----LEGKTCGTGPSLAAVFEDDKNFHTIISQIKETIQAAFESARIYAATFEKFQ 622

Query: 720  TMTEKAKIMSMKISSMGELTSKEFEAILNRFRNYFRHIVNMAIEKRIGIFNVVSLDYQSE 779
               ++ + + ++   + E     F   L ++    +  V +   + +G+  + +   + +
Sbjct: 623  IFFKENESLDLQALKLQEPDINFFSEQLEKYHKQHKDAVALRPTRNVGLLLIDTRLLREK 682

Query: 780  CLLYIDNVIHMSHTLIQSVIEKKNKNLLEVVESSLQQLECDPTEIEEFLEHFIFLNAISS 839
             +      + + + ++    +KK   ++   + +  +LE  PT   E++   +FL+ I  
Sbjct: 683  LIPSPLRCLEVLNFMLPRQSKKKVDAIIFEAQDAEYKLEFVPTTTTEYVHSLLFLDEIQE 742

Query: 840  KISKLEKEFLTMSQLYSVAKHHQIHISEEQIAIFQVLLLKFSQLKSSMKLSKINKDTAIT 899
            +I  LE E   ++Q+Y + + +Q+    E  A+F  +      +++++  S  +++++I 
Sbjct: 743  RIESLEDEGNIVTQMYKLMEQYQVPTPPEDFAVFATMKPSIVAVRNAIDKSVGDRESSIK 802

Query: 900  KFRDNLEACISGLHVDVGNLKAKIRTPLLLCAGTQVSTAMEMIQTLSGEAASLTNKAKAY 959
            +F  +L + +  L+ +V  +K + + P +L           ++  L    A L  +A  Y
Sbjct: 803  QFCVHLGSDLEELNNEVNEVKLQAQDPQILDISADQDKIRLILNNLQSVLADLQKRAFQY 862

Query: 960  SHYQDCFSDSQSHMHSVNVEEITQIVLSEISDIEGDLTLRKKLWEAQEEWKRASWEWRNS 1019
              YQ  F    S   +             + ++  +L L++ LW++  EW +   EW  S
Sbjct: 863  KSYQKNFKVEVSKFEA-------------LEEVSAELKLKQLLWDSFSEWDKLQQEWLKS 909

Query: 1020 SLQSIDVESVQRNVSKLMHIISVLEKGLPKSDMVTHLKQVVTEFKQELPIIIALGNPCLK 1079
                +D E +   VSK    ++ LEKGLP + +V  LK  V + K++LP+II L NP LK
Sbjct: 910  KFDCLDPEVLNGQVSKYAKFVTQLEKGLPPNSVVPQLKYKVEKMKEKLPVIIDLRNPTLK 969

Query: 1080 PRHWEALQEIIGKS-VPLDKNCKVENLLALKMFQYENEINDMSTSATNEAALEKMLFKII 1138
             RHW A+++ +  + V  +    +E L  L +F +  EI D+S  A+ EAALE +L K+ 
Sbjct: 970  ARHWAAIEQTVDATLVDAEIPLTLERLSQLHVFDFGQEIQDISGQASGEAALEAILKKVE 1029

Query: 1139 DFWNTTPLPLILHHTEIYSIFIIPSIDDISAQLEESQVILATIKGSPHIGPIKDLVNEWD 1198
            D W TT   +IL H +   +FI+   DDI   L++S + +AT+  S ++GP+K  V+EW 
Sbjct: 1030 DSWKTTEF-VILPHRDSKDVFILGGTDDIQVLLDDSTINVATLASSRYLGPLKTRVDEWQ 1088

Query: 1199 QNLTLFSYTLEEWMNCQRNWLYLEPVFHSSEIRRQLPAETELFSQVISMWKKIMSKIQNK 1258
            + L LF+ TLEEW+ CQRNWLYLE +F++ +I+RQLPAE ++F QV   WK+IM K+   
Sbjct: 1089 KQLALFNQTLEEWLTCQRNWLYLESIFNAPDIQRQLPAEAKMFLQVDKSWKEIMRKVNRL 1148

Query: 1259 QNALQITTSAGVLEILQNCNIHLEHIKKSLEDYLEVKRLIFPRFYFLSNAELLDILADSR 1318
             NAL+  T  G+LE  QN N  L+ I+K LE YLE KR+IFPRFYFLSN ELL+ILA +R
Sbjct: 1149 PNALRAATQPGLLETFQNNNALLDQIQKCLEAYLESKRVIFPRFYFLSNDELLEILAQTR 1208

Query: 1319 NPESVQPHLVKCFENIKQLLIWKQDIGPPA------------------VKMLISAEGEGL 1360
            NP++VQPHL KCF++I +L   +  + PPA                  +  ++S EGE +
Sbjct: 1209 NPQAVQPHLRKCFDSISKL---EFALMPPAEGKIPGIDGEPEKVYTNDILAMLSPEGERV 1265

Query: 1361 VLPKKIRVRSAVEQWLVNVEKSMFDVLK------------KERYIYNI------ILLFQS 1402
             L K ++ R  VE+WL  VE++MF  L+            K R  + +      ++L  S
Sbjct: 1266 SLGKGLKARGNVEEWLGKVEEAMFTSLRRLCKAAIADYQGKLRTDWVVAGHPSQVILTVS 1325

Query: 1403 QIMFYNDCVKSFVSSYSR-----EKLEKVHAGLMCHLEEVADLVVLDTSNSRTKAILGAL 1457
            QIM+  D  +   + +S      +  EKV+   +  L  +    V  +     + IL AL
Sbjct: 1326 QIMWCRDLTECLETEHSNHIQALKNFEKVNFERLNALAAI----VQGSLPKLHRNILTAL 1381

Query: 1458 LILYVHCRDIVINLLLKNIFNAEDFEWTRHLQYKWNEKQKLCYVSQGNASFTYGYEYLGC 1517
            + + VH RDIV  L+   +   E F+W R L+Y W+     C      + +TYGYEYLG 
Sbjct: 1382 ITIDVHARDIVTELVQSKVETVESFDWQRQLRYYWDIDLDNCVARMALSQYTYGYEYLGA 1441

Query: 1518 TSRLVITPLTDRCWLTLMEALHLNLGGCPAGPAGTGKTETVKDLAKSLGKHCVVFNCFED 1577
              RLVITPLTDRC+L LM AL L+LGG PAGPAGTGKTET KDLAK+L   CVVFNC + 
Sbjct: 1442 CPRLVITPLTDRCYLCLMGALQLDLGGAPAGPAGTGKTETTKDLAKALAIQCVVFNCSDG 1501

Query: 1578 LDYKIVRKFFFGLVQSGAWSCFDEFNLIDLEVLSVIASQILTIKAAKDNYSARFVLEGKE 1637
            LDYK++ +FF GL QSGAW CFDEFN ID+EVLSVIA Q++TI+ AK    +RF+ EG+E
Sbjct: 1502 LDYKMMGRFFSGLAQSGAWCCFDEFNRIDIEVLSVIAQQLITIRNAKAAKLSRFMFEGRE 1561

Query: 1638 IRINMSCAVFITMNPRYGGGVELPDNLKSLFRPVAMMVPHYQMIAEIILFSFGFKSANSL 1697
            I++ M+CA FITMNP Y G  ELPDNLK+LFRP AMMVP+Y +IAE+IL+S GF+S+  L
Sbjct: 1562 IKLVMTCAAFITMNPGYAGRTELPDNLKALFRPFAMMVPNYALIAEVILYSEGFESSKIL 1621

Query: 1698 SGKLTNLYELARKQLSQQDHYNFGLRSLKIVLIMAGTKKREFKCLSEADETLIVIEAIRE 1757
            + K+T +Y+L  +QLSQQDHY+FG+R++K VL+MAG+ KRE     + +E +++I A+++
Sbjct: 1622 ARKMTQMYKLCSEQLSQQDHYDFGMRAVKSVLVMAGSLKRE---NPDLNEDVVLIRALQD 1678

Query: 1758 ASLPKCPPEDVPLFENIIGDIFPEVTVLKVNQLALEKVIYTATQQLGLQNWSSQKEKIIQ 1817
            ++LPK   +D  LF  II D+FP V + + +   L+  I     +  LQ       K+IQ
Sbjct: 1679 SNLPKFLTDDALLFSGIISDLFPGVQIPEHDYGILQSTIVDVMNRQNLQPEMCMVRKVIQ 1738

Query: 1818 FYNQLQVCVGVMLVGPTGGGKTTVRRILEKALTLLPIADFLSVAERKSASKISERKGKVD 1877
            FY  + V  GVMLVGPTGGGKTTV RIL + L  L          +K   + S  +  V 
Sbjct: 1739 FYETMLVRHGVMLVGPTGGGKTTVYRILAETLGNL----------QKLGIENSFYQA-VK 1787

Query: 1878 ICVLNPKCVTLSELYGQLDPNTMEWTDGLLSATIRSYVYFNTPKNTKKDIDLRLKSRISD 1937
              VLNPK +T+ ELYG+++  T+EW DGL++ ++R+ V                      
Sbjct: 1788 TYVLNPKSITMGELYGEVNNLTLEWKDGLMALSVRAAV---------------------- 1825

Query: 1938 LSNVFKLDSSDTTETDDNIFEEIEKVVKIPENHNFDWQWIILDGPVDTFWVENLNSVLDD 1997
                     +DT+E                     D +WII DGPVD  W+EN+N+VLDD
Sbjct: 1826 ---------NDTSE---------------------DHKWIISDGPVDALWIENMNTVLDD 1855

Query: 1998 TRTLCLANSERIALTNKIRVIFEVDNLSQASPATVSRCAMVYMDPVDLGWEPYVKSWLLK 2057
             + LCLANSERI LT +I ++FEV +L  ASPATVSRC MV++DP +L W PYVK+W+  
Sbjct: 1856 NKMLCLANSERIKLTPQIHMLFEVQDLRVASPATVSRCGMVFVDPEELKWMPYVKTWMKG 1915

Query: 2058 TSKIISQSGVDCLEFMIKNSVTDGLQFIRNRQKFQPYPMEDITVVITLCRILDAFFDFMG 2117
             SK +++   + +  + +  V +GL FI N++  Q  P  DI+ V TLC +L++    +G
Sbjct: 1916 ISKKLTEETQEYILNLFQRYVDEGLHFI-NKKCSQAIPQVDISKVTTLCCLLESL--ILG 1972

Query: 2118 KNGGFEQSDDLNDTSSKEANSQRESVTFKDIEKRDENTWYPEKNPDKLTKIIQKLFVFAF 2177
            K+G                N   E                      KL  I+ + FVF +
Sbjct: 1973 KDG---------------VNLAMEQT--------------------KLNTILCQTFVFCY 1997

Query: 2178 TWAFGGALNREDEHRENIPFCPSLEPDSLAKVTYD-FDKLVHELFGNSSQVGWKHWGQSQ 2236
             W+ GG                     +L +  YD FD  +   F ++      + G   
Sbjct: 1998 LWSLGG---------------------NLTENYYDSFDTFIRTQFDDNPDARLPNSG--- 2033

Query: 2237 GRRRKGNCINLPTGECSIFGYFVDIEQCEFIPWSDLVPNDQTLIQRGTSLLTNLQRSGGN 2296
                             ++   +D +     PW  ++P  +    R       L      
Sbjct: 2034 ----------------DLWSIHMDFDTKRLDPWERIIPTFK--YNRDVPFFEML------ 2069

Query: 2297 FLKITECGECINYTATRDTTCLSFLMSLLLKNSCPVLLTGESGVGKTAAINQMLEKLEGP 2356
                           T DT    +LM  LL     VL TG +GVGK+     +L K++  
Sbjct: 2070 -------------VPTTDTVRYGYLMEKLLAVKHSVLFTGITGVGKSVIAKGLLNKIQES 2116

Query: 2357 GAFDIKHGSILGDTLLYSEIKKSSSLKQNITILIPETHKTATGSSDNPTKKPEVRTNKKL 2416
              +                          + + +  + +T++  +    +    R  K +
Sbjct: 2117 AGY--------------------------VPVYLNFSAQTSSARTQEIIESKLERKRKNI 2150

Query: 2417 LKNNDHKGVVVSTINFSTNVTAAKTKEMILKKLIRRTKDTLGAPKNNRILIFIDDMNMPV 2476
            L    +K +V+                           D L  P+ +R            
Sbjct: 2151 LGAPGNKRIVIFV-------------------------DDLNMPRLDR------------ 2173

Query: 2477 SDMYGAQPPLELIRQLLDLGGVYDTEKNTWKNIQDLSIVAACVPV---VNDISPRLLKHF 2533
               YG+QPP+EL+RQ  D GG YD  K  WK IQD++I++AC P     N ++PR ++HF
Sbjct: 2174 ---YGSQPPIELLRQYQDFGGFYDRNKLFWKEIQDVTIISACAPPGGGRNPVTPRFIRHF 2230

Query: 2534 SMLVLPHPSQDILCTIFQAHLGIYFSINNFTPEVQKSKDQIISCSLAIYHQVRQNMLPTP 2593
            SML LP PS+  L  IFQA L  + S  +F P V+++   I+  S+ IY+++  ++LPTP
Sbjct: 2231 SMLCLPMPSEHSLKQIFQAILNGFLS--DFPPAVKQTASSIVEASVEIYNKMSVDLLPTP 2288

Query: 2594 TKCHYMFNLRDMFKLLLGLLQADRTVVNSKEMAALLFVHEATRVFHDRLIDFTDKSLFYR 2653
             K HY+FNLRD+ K + G+LQ D   +  +     LF HE  RVFHDRLI+  DK  F+ 
Sbjct: 2289 AKSHYVFNLRDLSKCVQGILQCDPGTIREEIQIFRLFCHECQRVFHDRLINNEDKHYFHV 2348

Query: 2654 LLSRELENCFQIGID-----------------GCGK------------KTCATLACYLTD 2684
            +L+      F I ID                 G  K            KT   L  YL D
Sbjct: 2349 ILTEMANKHFGIAIDLEYFLNKPIIFGDFIKFGADKADRIYDDMPDIEKTANVLQDYLDD 2408

Query: 2685 NKL----------YRVPISH--KCAYIEFKEVFKKVFIHAGLKGKPTVLMVPN------- 2725
              L          ++  I H  + A +  +E    + +  G  GK ++  +         
Sbjct: 2409 YNLTNPKEVKLVFFQDAIEHVSRIARMIRQERGNALLVGVGGTGKQSLTRLAAHICGYKC 2468

Query: 2726 LNIE------QDSFLEDLNYIISSGRIPD------------------------------- 2748
            L IE       DSF EDL  +     + D                               
Sbjct: 2469 LQIELSRGYNYDSFHEDLRKLYKMAGVEDKNMVFLFTDTQIVVEEFLEDINNILNSGEVP 2528

Query: 2749 -LFENVELDSIAMKIRYLTEQSGHMD-NRQSLLSFFQKRIYKNLHIFVIMSPEGPSFRQN 2806
             LFE  EL+ +    R   ++ G  + NR  +  +F  ++ + LHI + MSP G +FR  
Sbjct: 2529 NLFEKDELEQVLAATRPRAKEVGISEGNRDEVFQYFISKVRQKLHIVLCMSPVGEAFRSR 2588

Query: 2807 CRVYPSMISSCTIDWYERWPEEALLIVANSFLKEKVNFENRENLKEKLAPTCVQIHKSMK 2866
            CR++PS+++ CTIDW+ +WP EALL V+ +F  + V+  N E LKEKL   CV +H S+ 
Sbjct: 2589 CRMFPSLVNCCTIDWFVQWPREALLSVSKTFFSQ-VDAGN-EELKEKLPLMCVNVHLSVS 2646

Query: 2867 DLNRKYFEETGRFYYTTPNSYLQFMETFAHILRAREEEMQTKRDRFHMGLSTILEATTLV 2926
             +  +Y+ E  R YYTTP SYL+ +  +  +L  + +++ + RDR   GL+ +LE   LV
Sbjct: 2647 SMAERYYNELRRRYYTTPTSYLELINLYLSMLSEKRKQIISARDRVKNGLTKLLETNILV 2706

Query: 2927 TEMQEELLILGPQVEQKTKETETLMEKLRKDSQVVEKVQMLVKQDE---EIVAEEVRIVE 2983
             +M+ +L  L P +  K+++ E LMEKL  D +  ++V+  V++DE   ++ AEE + + 
Sbjct: 2707 DKMKLDLSALEPVLLAKSEDVEALMEKLAVDQESADQVRNTVQEDEATAKVKAEETQAIA 2766

Query: 2984 DYAQKTANELKSVLPAFDKAIVALNALDKADVAELRVYTRPPFLVLTVMNAVCILLQKKP 3043
            D AQ+   +L   LPA D A  AL++LDKAD++E+RV+T+PP LV+TVM A+ ILL  KP
Sbjct: 2767 DDAQR---DLDEALPALDAANKALDSLDKADISEIRVFTKPPDLVMTVMEAISILLNAKP 2823

Query: 3044 NWATAKLLLSETGFLKKLINLDKDSIPDKVFVKLKKIVTLPDFNPHKISLVSVACCSLCQ 3103
            +W +AK LL ++ FLK+L+  DK++I  ++  KL+K +  PDF P K+  VS AC S+C 
Sbjct: 2824 DWPSAKQLLGDSNFLKRLLEYDKENIKPQILAKLQKYINNPDFVPEKVEKVSKACKSMCM 2883

Query: 3104 WVIALNNYHEVQKVVGPKQIQVAEAQNVLKIARQRLAEKQRGLQLVEEHLLFLQAAYKDT 3163
            WV A++ Y  V KVV PK+ ++  AQ  L I    L EKQ  L+ VE+ +  LQ  Y   
Sbjct: 2884 WVRAMDLYSRVVKVVEPKRQKLRAAQAELDITMATLREKQALLRQVEDQIQALQDEYDKG 2943

Query: 3164 VAEKQLLANRKTMASRRFQCASVLLTVLEDEKTRWQETINQIDNKLEGILGDILLSAACI 3223
            V EK+ LA    +   R   A  L   LEDE+ RW+E+I + + ++  I G++ ++AAC+
Sbjct: 2944 VNEKESLAKTMALTKARLVRAGKLTAALEDEQVRWEESIQKFEEEISNITGNVFIAAACV 3003

Query: 3224 VYSGILTPEFRQLIVNKWETFCIENGISLSSKFSLIKVMAQKYEISRWHNQGLPHGQYSV 3283
             Y G  T ++RQ ++  W   C    I +   FSLI ++   YEI +W+  GLP    S 
Sbjct: 3004 AYYGAFTAQYRQSLIECWIQDCQSLEIPIDPSFSLINILGDPYEIRQWNTDGLPRDLIST 3063

Query: 3284 ENAILIKNGQQWPLLIDPHRQAHKWIRQMEG-SRLQKLSIEDSNYTKKIENAMKTGGSVL 3342
            EN IL+  G++WPL+IDP  QA++WIR  E  S L+ + + DSN+ + +EN+++ G  VL
Sbjct: 3064 ENGILVTQGRRWPLMIDPQDQANRWIRNKESKSGLKIIKLTDSNFLRILENSIRLGLPVL 3123

Query: 3343 LQNLLETLAPGLKAILKKDIYQKKGHYFIRVGDAEFEYNSNFRLYLSTEIDNPHFLPSVY 3402
            L+ L ETL P L+ IL K I+   G   IR+GD++ +Y+ NFR Y++T++ NPH+LP V 
Sbjct: 3124 LEELKETLDPALEPILLKQIFISGGRLLIRLGDSDIDYDKNFRFYMTTKMPNPHYLPEVC 3183

Query: 3403 NFVTMINFTVTFQGLQDQLLSTVVTHEVPHLEDQRSKLLESISLDAITLEELEEKTLNLL 3462
              VT+INFTVT  GL+DQLLS VV  E P LE+QR KL+  I+ D   L+ +EEK L +L
Sbjct: 3184 IKVTIINFTVTKSGLEDQLLSDVVRLEKPRLEEQRIKLIVRINTDKNQLKTIEEKILRML 3243

Query: 3463 QKALGSILDDDKIVDTLRKSKMTSNEISKRIEATKKAESEIQAIRKNYLPIATRGALLYF 3522
              + G+ILD+++++DTL+ SK+TS  I  R+E  +  E  I   R+ Y P+AT+G+++YF
Sbjct: 3244 FTSEGNILDNEELIDTLQDSKITSGAIKTRLEEAESTEQMINVAREKYRPVATQGSVMYF 3303

Query: 3523 LVADLTQINYMYQFSLDWFHQVFVSSVVSKSKEQEHSFKREKVSPKEVHEFISISKEPNL 3582
            ++A L++I+ MYQ+SL +F Q+F +++       E S K E                 NL
Sbjct: 3304 VIASLSEIDPMYQYSLKYFKQLFNTTI-------ETSVKTE-----------------NL 3339

Query: 3583 ENEKNLLDKHIKSAIDMLTKSIFKVVSSALFNEDKLCFSFRLCTVIMQNNANGNLIQDDI 3642
            +   ++L       ++    + +  VS  LF + KL +SF LC  +M+            
Sbjct: 3340 QQRLDVL-------LEQTLLTAYVNVSRGLFEQHKLIYSFMLCVEMMRQQ---------- 3382

Query: 3643 GFLPEEEWNIFLYSGILINIKSALSQSRLTSTFEIGESQHLQWLSDSRWRQCQYVSTHLE 3702
            G L + EWN FL         + L + R              WL  + W  C  +     
Sbjct: 3383 GTLSDAEWNFFLRG------SAGLEKER-------PPKPEAPWLPTATWFACCDLEESFP 3429

Query: 3703 PFSLLCKSLLSN-----VSQWDTFKNSKAVYSLISTPFSSENASLEENTKPPEETELLNE 3757
             F  L +++LS+     +  ++T+ N +                 E  +K   E + + +
Sbjct: 3430 VFHGLTQNILSHPISIRLGSFETYINPQ---------------KWEGYSKMKHEDKHMRQ 3474

Query: 3758 NKETCNPINFPWEK-LTSFQRLILVKVLRPESLNNSVRKFITEKMGNKYLQRTGVNLKDA 3816
             KE  +    PW   L+SF +LIL+K  + E +  ++  F+ E +G ++++   V+L   
Sbjct: 3475 EKEAAH--QDPWSAGLSSFHKLILIKCCKEEKVVFALTDFVIENLGKQFIETPPVDLPTL 3532

Query: 3817 YKGSNARTPLILIQTHGIDLTNILLRFAQELKGTTHHVTIISLGRDQAAKAEDLILKALT 3876
            Y+  +  TPL+ I + G D      RFA+E  G +  V  ISLG+ Q   AE ++  A+ 
Sbjct: 3533 YQDMSCNTPLVFILSTGSDPMGAFQRFARE-SGYSERVQSISLGQGQGPIAEKMVKDAM- 3590

Query: 3877 KTQQWVFLQNCHLATSFMPRLCTIVESFNSPNVTIDPEFRLWLSSKSYSSFPIPVLKKGL 3936
            K+  WVFLQNCHLA S+M  +  ++++F  P+  I   FRL+LSS   ++FP+ VL+  +
Sbjct: 3591 KSGNWVFLQNCHLAVSWMLAMEELIKTFTDPDSAIKDTFRLFLSSMPSNTFPVTVLQNSV 3650

Query: 3937 KIAVESPQGLKSNLLQTFGCTGSGEVTEEIFENPDCGQWWKKLLFSLCFFNAVINERKNY 3996
            K+  E P+GL++N+ + F      E+T   FE    G+ W++++F +CFF+A+I ERK +
Sbjct: 3651 KVTNEPPKGLRANIRRAF-----TEMTPSFFEENILGKKWRQIIFGICFFHAIIQERKKF 3705

Query: 3997 GILGWNIAYKFNSSDLGVAIKVLENSLRGQPSISWQALRYLIGEVIYGGRVIDNWDKRCL 4056
            G LGWNI Y+FN SD   A+  L+   + +  I W AL Y+ GE+ YGGRV D+WD+RCL
Sbjct: 3706 GPLGWNICYEFNDSDRECALLNLKLYCK-EGKIPWDALIYITGEITYGGRVTDSWDQRCL 3764

Query: 4057 KTLLYKFCNPEVLKDDFSFSRSA--------SIKDYIHIIQSLPDDDLPEVLGIHPEAIR 4108
            +T+L +F +PE L++D+ +S S         S++++   I++LP  D PE+ G+H  A  
Sbjct: 3765 RTILKRFFSPETLEEDYKYSESGIYFAPMADSLQEFKDYIENLPLIDDPEIFGMHENANL 3824

Query: 4109 SCWETQGEKFIENLIAMQPKTTTANLMIRPEQSKDELVMEILSDLLKRLPLTVEKEEIAV 4168
                 +    I  ++ +QP+++T        +S DE+V E+++ +  R+P  +E E    
Sbjct: 3825 VFQYKETSTLINTILEVQPRSSTGG----EGKSNDEIVQELVASVQTRVPEKLEME---- 3876

Query: 4169 GTPSTLKSMMSSSIWESLSKNLKDHDPLIHCVLLTFLKQEIKRFDKLLFVIHKSLKDLQL 4228
                  +S+    +   L+             L T L QE+ RF+ LL +IH SL+ L  
Sbjct: 3877 ---GASESLFVKDLQGRLNS------------LTTVLGQEVDRFNNLLKLIHTSLETLNK 3921

Query: 4229 AIKGEIILTQELEEIFNSFLNMRVPTLWQKHAYRSCKPLSSWIDDLIQRLNFFNTWAKVA 4288
            AI G +++++E+E+++NSFLN +VP LW   AY S KPL SW+ DLI R +F + W K  
Sbjct: 3922 AIAGFVVMSEEMEKVYNSFLNNQVPALWSNTAYPSLKPLGSWVKDLILRTSFVDLWLK-- 3979

Query: 4289 YTAIQRRYMRFVTVWKQSIPSTSQKCKHPEDSENNFFEGFPSRYWLPAFFFPQAFLAAVL 4348
                                                  G P  YW+  FFFPQ FL   L
Sbjct: 3980 -------------------------------------RGQPKSYWISGFFFPQGFLTGTL 4002

Query: 4349 QDYGRSRGIAVDALTFTHHVISNTTD--------KDEKFSVFMPKKLNIVRRAFKGSASS 4400
            Q++ R   + +D L+F + VI    D        K  +F   +P  + +         S 
Sbjct: 4003 QNHARKYNLPIDELSFKYSVIPTYRDQAAVIEAAKTVQFGQELPMDMEL--------PSP 4054

Query: 4401 HTGVYIFGLFIEGARWNREQKILEDSLPLEMCCDFPDIYFLPTKISTKTPNASNQTDSEL 4460
              GV + G+F++ +RW+ ++ ++ED+LP +M    P ++F P +    +P          
Sbjct: 4055 EDGVLVHGMFMDASRWDDKEMVIEDALPGQMNPVLPVVHFEPQQNYKPSPT--------- 4105

Query: 4461 YAFECPVYQTPERSRILATTGLPTNFLTSVYLSTKKPPSHWITMRVALLCEKNE 4514
              + CP+Y+T  R+  L+TTG  TNF+ +V L +K+   +WI    ALLC+ +E
Sbjct: 4106 -LYHCPLYKTGARAGTLSTTGHSTNFVVTVLLPSKRSKDYWIAKGSALLCQLSE 4158



 Score = 65.5 bits (158), Expect = 1e-09
 Identities = 49/186 (26%), Positives = 88/186 (47%), Gaps = 20/186 (10%)

Query: 175 FVYCLPRKSPKSL-YNPYDLQVVSAHTAKHCKEFWVITASFISKVINIVGSVKEVELIPT 233
           F+Y +P     S+ Y+ Y+L+VVS        +++ I+   ++ + N     +++E I  
Sbjct: 201 FLYMIPAVPRSSIEYDTYNLKVVSYENINK-NDYYTISQRAVTHIYN-----EDIEFIEI 254

Query: 234 LEWLSERRHYYLLRQFKIFSDFRMNKAFVTWKLNVKRIKTEKSRSFLYHHLFLADDLFQT 293
             W  E  ++  L +  IFS FR  KAF  W+ NV+  K    +  L  +LF+ +   + 
Sbjct: 255 DRWEQEYLYHRELTKIPIFSLFRKWKAFSVWRKNVRSKKITGCQKSLQKNLFIVNPHLRP 314

Query: 294 CLVYIRGLCEDAINLKNYNDHENNLSAICLVKLDSSRTYSLDEFCEEQLQQATQALKQLE 353
            L+ I  LC              +LS + L  ++   TY+L EF   Q+ +  +  ++L 
Sbjct: 315 ALLKINELC-------------YHLSFMGLCYIEKCHTYTLQEFKAAQVIRLAEVTERLG 361

Query: 354 DIRNKA 359
           + RN+A
Sbjct: 362 EFRNEA 367


>gi|197927452 dynein, axonemal, heavy chain 1 [Homo sapiens]
          Length = 4265

 Score =  975 bits (2520), Expect = 0.0
 Identities = 587/1884 (31%), Positives = 976/1884 (51%), Gaps = 221/1884 (11%)

Query: 2653 RLLSRELENCFQIGIDGCGKKTCATLACYLTDNKLYRVPISHKCAYIEFKEVFKKVFIHA 2712
            R L + L N   +G+ G G+ +   LA ++ + + +++ +S      E+++  KKV + A
Sbjct: 2573 RTLRQALGNALLLGVGGSGRSSLTRLASHMAEYECFQIELSKNYGMSEWRDDVKKVLLKA 2632

Query: 2713 GLKGKPTVLMVPNLNIEQDSFLEDLNYIISSGRIPDLFENVELDSIAMKIRYLTEQSGHM 2772
            GL+  P   +  +  I+ +SFLED+N +++SG IP+L+   E D I   +R   ++ G  
Sbjct: 2633 GLQNLPITFLFSDTQIKNESFLEDINNVLNSGDIPNLYTADEQDQIVSTMRPYIQEQGLQ 2692

Query: 2773 DNRQSLLSFFQKRIYKNLHIFVIMSPEGPSFRQNCRVYPSMISSCTIDWYERWPEEALLI 2832
              + +L++ +  R+  N+H+ + MSP G  FR   R +PS+++ CTIDW+  WP EAL  
Sbjct: 2693 PTKANLMAAYTGRVRSNIHMVLCMSPIGEVFRARLRQFPSLVNCCTIDWFNEWPAEALKS 2752

Query: 2833 VANSFLKEKVNFENRENLKEKLAPTCVQIHKSMKDLNRKYFEETGRFYYTTPNSYLQFME 2892
            VA  FL E    E+ +   + L   CV IH+S+     +Y  E  R  Y TP SYL+ + 
Sbjct: 2753 VATVFLNEIPELESSQEEIQGLIQVCVYIHQSVSKKCIEYLAELTRHNYVTPKSYLELLH 2812

Query: 2893 TFAHILRAREEEMQTKRDRFHMGLSTILEATTLVTEMQEELLILGPQVEQKTKETETLME 2952
             F+ ++  ++ E++T ++R   GL  +L  +  V +MQE+L  + P +E+  K+T   ME
Sbjct: 2813 IFSILIGQKKLELKTAKNRMKSGLDKLLRTSEDVAKMQEDLESMHPLLEEAAKDTMLTME 2872

Query: 2953 KLRKDSQVVEKVQMLVKQDEEIVAEEVRIVEDYAQKTANELKSVLPAFDKAIVALNALDK 3012
            +++ D+ + E+ +  V+ +E    E+ +  +  A     +L   LPA D A+ +L  L+K
Sbjct: 2873 QIKVDTAIAEETRNSVQTEEIKANEKAKKAQAIADDAQKDLDEALPALDAALASLRNLNK 2932

Query: 3013 ADVAELRVYTRPPFLVLTVMNAVCILLQKKPN--------------WATAKLLLSETG-F 3057
             DV E+R   RPP  V  V+ AVCI+   KP               W   K LL + G F
Sbjct: 2933 NDVTEVRAMQRPPPGVKLVIEAVCIMKGIKPKKVPGEKPGTKVDDYWEPGKGLLQDPGHF 2992

Query: 3058 LKKLINLDKDSIPDKVFVKLKKIVTLPDFNPHKISLVSVACCSLCQWVIALNNYHEVQKV 3117
            L+ L   DKD+I D V   ++  +   +F P  I+ VS AC S+CQWV A++ YH V K 
Sbjct: 2993 LESLFKFDKDNIGDVVIKAIQPYIDNEEFQPATIAKVSKACTSICQWVRAMHKYHFVAKA 3052

Query: 3118 VGPKQIQVAEAQNVLKIARQRLAEKQRGLQLVEEHLLFLQAAYKDTVAEKQLLANRKTMA 3177
            V PK+  + EAQ+ L + ++ L E ++ L+ VE+ +  +QA Y++ + +K+ L  +    
Sbjct: 3053 VEPKRQALLEAQDDLGVTQRILDEAKQRLREVEDGIATMQAKYRECITKKEELELKCEQC 3112

Query: 3178 SRRFQCASVLLTVLEDEKTRWQETINQIDNKLEGILGDILLSAACIVYSGILTPEFRQLI 3237
             +R   A  L+  L DEK RWQET+  +   L  I GD+L++A  + Y G  T ++R ++
Sbjct: 3113 EQRLGRAGKLINGLSDEKVRWQETVENLQYMLNNISGDVLVAAGFVAYLGPFTGQYRTVL 3172

Query: 3238 VNKWETFCIENGISLSSKFSLIKVMAQKYEISRWHNQGLPHGQYSVENAILIKNGQQWPL 3297
             + W      + +  +S+ +LI  +    +I  W   GLP+   SVEN ++ +  Q+W  
Sbjct: 3173 YDSWVKQLRSHNVPHTSEPTLIGTLGNPVKIRSWQIAGLPNDTLSVENGVINQFSQRWTH 3232

Query: 3298 LIDPHRQAHKWIRQME-GSRLQKLSIEDSNYTKKIENAMKTGGSVLLQNLLETLAPGLKA 3356
             IDP  QA+KWI+ ME  + L    + D ++ + +ENA++ G   LL+N+ E L P L+ 
Sbjct: 3233 FIDPQSQANKWIKNMEKDNGLDVFKLSDRDFLRSMENAIRFGKPCLLENVGEELDPALEP 3292

Query: 3357 ILKKDIYQKKGHYFIRVGDAEFEYNSNFRLYLSTEIDNPHFLPSVYNFVTMINFTVTFQG 3416
            +L K  Y+++G+  +++GD    Y+ +FR+Y++T++ NPH+ P +   +T+INFT++  G
Sbjct: 3293 VLLKQTYKQQGNTVLKLGDTVIPYHEDFRMYITTKLPNPHYTPEISTKLTLINFTLSPSG 3352

Query: 3417 LQDQLLSTVVTHEVPHLEDQRSKLLESISLDAITLEELEEKTLNLLQKALGSILDDDKIV 3476
            L+DQLL  VV  E P LE+ +++L+ S +     L+++E++ L  L  + G+ +DD +++
Sbjct: 3353 LEDQLLGQVVAEERPDLEEAKNQLIISNAKMRQELKDIEDQILYRLSSSEGNPVDDMELI 3412

Query: 3477 DTLRKSKMTSNEISKRIEATKKAESEIQAIRKNYLPIATRGALLYFLVADLTQINYMYQF 3536
              L  SKM + EI  ++   ++ E +I   R  Y+P+A R  +L+F V+DL  ++ MYQ+
Sbjct: 3413 KVLEASKMKAAEIQAKVRIAEQTEKDIDLTRMEYIPVAIRTQILFFCVSDLANVDPMYQY 3472

Query: 3537 SLDWFHQVFVSSVVSKSKEQEHSFKREKVSPKEVHEFISISKEPNLENEKNLLDKHIKSA 3596
            SL+WF  +F+S + +  +                                  L K I + 
Sbjct: 3473 SLEWFLNIFLSGIANSERADN-------------------------------LKKRISNI 3501

Query: 3597 IDMLTKSIFKVVSSALFNEDKLCFSFRLCTVIMQNNANGNLIQDDIGFLPEEEWNIFLYS 3656
               LT S++  V  +LF + KL F+F LC  IM N           G + + EW  +L S
Sbjct: 3502 NRYLTYSLYSNVCRSLFEKHKLMFAFLLCVRIMMNE----------GKINQSEWR-YLLS 3550

Query: 3657 GILINIKSALSQSRLTSTFEIGESQHLQWLSDSRWRQCQYVSTHLEPFSLLCKSLLSNVS 3716
            G  I+I +              E+    WLSD  WR    +S +L  FS      + ++S
Sbjct: 3551 GGSISIMT--------------ENPAPDWLSDRAWRDILALS-NLPTFSSFSSDFVKHLS 3595

Query: 3717 QWDTFKNSKAVYSLISTPFSSENASLEENTKPPEETELLNENKETCNPINFPWEK-LTSF 3775
            ++    +S                              L  ++E   P+   W++ L  F
Sbjct: 3596 EFRVIFDS------------------------------LEPHRE---PLPGIWDQYLDQF 3622

Query: 3776 QRLILVKVLRPESLNNSVRKFITEKMGNKYLQRTGVNLKDAYKGSNARTPLILIQTHGID 3835
            Q+L++++ LR + + N+++ F+   +  ++++    NL   +K SN+ TPLI + + G D
Sbjct: 3623 QKLLVLRCLRGDKVTNAMQDFVATNLEPRFIEPQTANLSVVFKDSNSTTPLIFVLSPGTD 3682

Query: 3836 LTNILLRFAQELKGTTHHVTIISLGRDQAAKAEDLILKALTKTQQWVFLQNCHLATSFMP 3895
                L +FA+E+K  +  ++ ISLG+ Q  +AE ++  ++ +  +WVF QNCHLA S+MP
Sbjct: 3683 PAADLYKFAEEMK-FSKKLSAISLGQGQGPRAEAMMRSSIER-GKWVFFQNCHLAPSWMP 3740

Query: 3896 RLCTIVESFNSPNVTIDPEFRLWLSSKSYSSFPIPVLKKGLKIAVESPQGLKSNLLQTFG 3955
             L  ++E  N   V  D  FRLWL+S   + FP+ +L+ G K+ +E P+G+++NLL+++ 
Sbjct: 3741 ALERLIEHINPDKVHRD--FRLWLTSLPSNKFPVSILQNGSKMTIEPPRGVRANLLKSYS 3798

Query: 3956 CTGSGEVTEEIFENPDCGQWWKKLLFSLCFFNAVINERKNYGILGWNIAYKFNSSDLGVA 4015
              G     E+   +      +K LL SLC F+    ER+ +G LG+NI Y+F   DL + 
Sbjct: 3799 SLG-----EDFLNSCHKVMEFKSLLLSLCLFHGNALERRKFGPLGFNIPYEFTDGDLRIC 3853

Query: 4016 IKVLENSLRGQPSISWQALRYLIGEVIYGGRVIDNWDKRCLKTLLYKFCNPEVLKDDFSF 4075
            I  L+  L     I ++ L+Y  GE+ YGGRV D+WD+RC+  +L  F NP+VL  + S+
Sbjct: 3854 ISQLKMFLDEYDDIPYKVLKYTAGEINYGGRVTDDWDRRCIMNILEDFYNPDVLSPEHSY 3913

Query: 4076 SRSA---------SIKDYIHIIQSLPDDDLPEVLGIHPEAIRSCWETQGEKFIENLIAMQ 4126
            S S           +  Y+  I+SLP +D+PE+ G+H  A  +  + +    +  +I +Q
Sbjct: 3914 SASGIYHQIPPTYDLHGYLSYIKSLPLNDMPEIFGLHDNANITFAQNETFALLGTIIQLQ 3973

Query: 4127 PKTTTANLMIRPEQSKDELVMEILSDLLKRLPLTVEKEEIAVGTPSTLKSMMSSSIWESL 4186
            PK+++A       Q ++E+V ++  ++L ++P  +  + +    P   +  M+       
Sbjct: 3974 PKSSSAG-----SQGREEIVEDVTQNILLKVPEPINLQWVMAKYPVLYEESMN------- 4021

Query: 4187 SKNLKDHDPLIHCVLLTFLKQEIKRFDKLLFVIHKSLKDLQLAIKGEIILTQELEEIFNS 4246
                            T L QE+ R+++LL VI ++L+DL  A+KG ++++ +LE +  S
Sbjct: 4022 ----------------TVLVQEVIRYNRLLQVITQTLQDLLKALKGLVVMSSQLELMAAS 4065

Query: 4247 FLNMRVPTLWQKHAYRSCKPLSSWIDDLIQRLNFFNTWAKVAYTAIQRRYMRFVTVWKQS 4306
              N  VP LW   AY S KPLSSW+ DL+QRL+F   W +                    
Sbjct: 4066 LYNNTVPELWSAKAYPSLKPLSSWVMDLLQRLDFLQAWIQ-------------------- 4105

Query: 4307 IPSTSQKCKHPEDSENNFFEGFPSRYWLPAFFFPQAFLAAVLQDYGRSRGIAVDALTFTH 4366
                               +G P+ +W+  FFFPQAFL   LQ++ R   I++D ++F  
Sbjct: 4106 -------------------DGIPAVFWISGFFFPQAFLTGTLQNFARKFVISIDTISF-- 4144

Query: 4367 HVISNTTDKDEKFSVFMPKKLNIVRRAFKGSASSHTGVYIFGLFIEGARWNREQKILEDS 4426
                     D K     P +L         +     G YI GLF+EGARW+ E   L +S
Sbjct: 4145 ---------DFKVMFEAPSEL---------TQRPQVGCYIHGLFLEGARWDPEAFQLAES 4186

Query: 4427 LPLEMCCDFPDIYFLPTKISTKTPNASNQTDSELYAFECPVYQTPERSRILATTGLPTNF 4486
             P E+  +   I+ LP      TPN   Q D + Y   CP+Y+T  R+  L+TTG  TN+
Sbjct: 4187 QPKELYTEMAVIWLLP------TPNRKAQ-DQDFYL--CPIYKTLTRAGTLSTTGHSTNY 4237

Query: 4487 LTSVYLSTKKPPSHWITMRVALLC 4510
            + +V + T +P  HWI   VAL+C
Sbjct: 4238 VIAVEIPTHQPQRHWIKRGVALIC 4261



 Score =  762 bits (1968), Expect = 0.0
 Identities = 491/1464 (33%), Positives = 763/1464 (52%), Gaps = 129/1464 (8%)

Query: 687  DPAYQNIIVNLLTIIGNSMGLVNAYSHKFIKYCTMTEKAKIMSMKI-SSMGELTSKEFEA 745
            +P  + +   + + +  +M  + AY+ ++ KY  +        +K   + G L  +  E 
Sbjct: 723  EPLVEELRATIASAVSKAMIPLQAYAKEYRKYLELNNNDIASFLKTYQTQGLLAQEVREV 782

Query: 746  ILNRFRNYFRHIVNMAIEKRIGIFNVVSLDYQSECLLYIDNVIHM----SHTLIQSVIEK 801
            +L   R   + I++ ++   I I             +  DNV          L  SV++ 
Sbjct: 783  VLTHLRE--KEILDSSLPSSIII---------GPFYINTDNVKQSLSKKRKALATSVLDI 831

Query: 802  KNKNLLEVVESSLQQLEC-------DPTEIEEFLEHFIFLNAISSKISKLEKEFLTMSQL 854
              KNL + V+S  ++           P  IEE  E   ++  I  ++  LE+  + +   
Sbjct: 832  LAKNLHKEVDSICEEFRSISRKIYEKPNSIEELAELREWMKGIPERLVGLEERIVKVMDD 891

Query: 855  YSVAKHHQIHISEEQIAIFQVLLLKFSQLKSSMKLSKINKDTAITKFRDNLEACISGLHV 914
            Y V      ++S +      +     S++   ++L +        KFR  ++       +
Sbjct: 892  YQVMDEFLYNLSSDDFNDKWIASNWPSKILGQIELVQQQHVEDEEKFR-KIQI------M 944

Query: 915  DVGNLKAKIRTPLLLCAGTQVSTAMEMIQTLSGEAASLTNKAKAYSHYQDCFSDSQSHMH 974
            D  N + K+    L+ AG  +   +     ++ E   +  + K      DC   +  + +
Sbjct: 945  DQNNFQEKLEGLQLVVAGFSIHVEISRAHEIANEVRRVKKQLK------DCQQLAMLYNN 998

Query: 975  SVNVEEITQIVLSEISDIEGDLTLRKKLWEAQEEWKRASWEWRNSSLQSIDVESVQRNVS 1034
               +  +      ++S +  +      LW    +W R S  W N  L +ID E +++NV 
Sbjct: 999  RERIFSLPITNYDKLSRMVKEFQPYLDLWTTASDWLRWSESWMNDPLSAIDAEQLEKNVV 1058

Query: 1035 ---KLMHIISVLEKGLPK-SDMVTHLKQVVTEFKQELPIIIALGNPCLKPRHWEALQEII 1090
               K MH      K +P   ++   ++  + EFK  +P+I  L NP ++ RHWE L   I
Sbjct: 1059 EAFKTMHKCVKQFKDMPACQEVALDIRARIEEFKPYIPLIQGLRNPGMRIRHWETLSNQI 1118

Query: 1091 GKSVPLDKNCKVENLLALKMFQYENEINDMSTSATNEAALEKMLFKIIDFWNTTPLPLIL 1150
              +V    N      L + +  +   I+ ++  A  E A+E+ L K+   W+T    ++ 
Sbjct: 1119 NINVRPKANLTFARCLEMNLQDHIESISKVAEVAGKEYAIEQALDKMEKEWSTILFNVLP 1178

Query: 1151 HHTEIYSIFIIPSIDDISAQLEESQVILATIKGSPHIGPIKDLVNEWDQNLTLFSYTLEE 1210
            +       +I+ S D+ S  L++  V+   +  SP+  P +  +N W+  L L    LEE
Sbjct: 1179 YKAT--DTYILKSPDEASQLLDDHIVMTQNMSFSPYKKPFEQRINSWENKLKLTQEVLEE 1236

Query: 1211 WMNCQRNWLYLEPVFHSSEIRRQLPAETELFSQVISMWKKIMSKIQNKQNALQITTSAGV 1270
            W+NCQR+WLYLEP+F S +I +QLP E++ +  +  +WKKIM      +  + + +   +
Sbjct: 1237 WLNCQRSWLYLEPIFSSEDINQQLPVESKRYQTMERIWKKIMKNAYENREVINVCSDLRM 1296

Query: 1271 LEILQNCNIHLEHIKKSLEDYLEVKRLIFPRFYFLSNAELLDILADSRNPESVQPHLVKC 1330
            L+ L++CN  L+ ++K L +YLE KR  FPRFYFLS+ ELL+IL+ +++P +VQPHL KC
Sbjct: 1297 LDSLRDCNKILDLVQKGLSEYLETKRSAFPRFYFLSDDELLEILSQTKDPTAVQPHLRKC 1356

Query: 1331 FENIKQLLIWKQDIGPPAVKMLISAEGEGLVLPKKIRVRSAVEQWLVNVEKSM----FDV 1386
            FENI +LL +++D+    +  + SAEGE + L   I   S VE WL  VE+SM     D+
Sbjct: 1357 FENIARLL-FQEDL---EITHMYSAEGEEVQLCFSIYPSSNVEDWLREVERSMKASVHDI 1412

Query: 1387 LKKERYIYNIILLFQSQIMFYNDCVKSFVSSY-SREKLEKVHAG-LMCHL-----EEVAD 1439
            ++K    Y  +   Q  + +      +   +Y + E  E + AG L   L     ++++D
Sbjct: 1413 IEKAIRAYPTMPRTQWVLNWPGQVTIAGCQTYWTMEVAEALEAGNLRSQLFPQLCQQLSD 1472

Query: 1440 LVVLDTS--NSRTKAILGALLILYVHCRDIVINLLLKNIFNAEDFEWTRHLQYKWNEKQK 1497
            LV L     +   +A+L AL+++ VH +D+V  L+ +N+ +  DF+W   L+Y W     
Sbjct: 1473 LVALVRGKLSRMQRAVLSALIVIEVHAKDVVSKLIQENVVSVNDFQWISQLRYYWTNND- 1531

Query: 1498 LCYVSQGNASFTYGYEYLGCTSRLVITPLTDRCWLTLMEALHLNLGGCPAGPAGTGKTET 1557
              Y+   NA F YGYEYLG + RLVITPLTDRC+LTL  ALHL  GG PAGPAGTGKTET
Sbjct: 1532 -LYIRAVNAEFIYGYEYLGNSGRLVITPLTDRCYLTLTGALHLKFGGAPAGPAGTGKTET 1590

Query: 1558 VKDLAKSLGKHCVVFNCFEDLDYKIVRKFFFGLVQSGAWSCFDEFNLIDLEVLSVIASQI 1617
             KDL K+L    VVFNC + LD+  + KFF GL  +GAW+CFDEFN ID+EVLSV+A QI
Sbjct: 1591 TKDLGKALAIQTVVFNCSDQLDFMAMGKFFKGLASAGAWACFDEFNRIDIEVLSVVAQQI 1650

Query: 1618 LTIKAAKDNYSARFVLEGKEIRINMSCAVFITMNPRYGGGVELPDNLKSLFRPVAMMVPH 1677
             TI+ A+     RF+ EG EI +  SCAVFITMNP Y G  ELPDNLK+LFRPVAMMVP 
Sbjct: 1651 TTIQKAQQQRVERFMFEGVEIPLVPSCAVFITMNPGYAGRTELPDNLKALFRPVAMMVPD 1710

Query: 1678 YQMIAEIILFSFGFKSANSLSGKLTNLYELARKQLSQQDHYNFGLRSLKIVLIMAGTKKR 1737
            Y MI EI L+SFGF  A+ L+ K+T  ++L+ +QLS QDHY+FG+R++K V+  AG  KR
Sbjct: 1711 YAMITEISLYSFGFNEASVLAKKITTTFKLSSEQLSSQDHYDFGMRAVKTVISAAGNLKR 1770

Query: 1738 EFKCLSEADETLIVIEAIREASLPKCPPEDVPLFENIIGDIFPEVTVLKVNQLALEKVIY 1797
            E   +   +E LI + AIR+ ++PK   ED+ LF  I+ D+FP +     +   L++ I 
Sbjct: 1771 ENPSM---NEELICLRAIRDVNVPKFLQEDLKLFSGIVSDLFPTIKEEDTDYGILDEAIR 1827

Query: 1798 TATQQLGLQNWSSQKEKIIQFYNQLQVCVGVMLVGPTGGGKTTVRRILEKALTLLPIADF 1857
             A +   L++      K IQ Y    V  G+MLVGPTG GK+T  R+L  A+T L     
Sbjct: 1828 EACRNSNLKDVEGFLTKCIQLYETTVVRHGLMLVGPTGSGKSTCYRVLAAAMTSLKGQPS 1887

Query: 1858 LSVAERKSASKISERKGKVDICVLNPKCVTLSELYGQLDPNTMEWTDGLLSATIRSYVYF 1917
            +S    ++          V+  VLNPK +T+ +LYG+ D  T EWTDG+ S+ IR+    
Sbjct: 1888 ISGGMYEA----------VNYYVLNPKSITMGQLYGEFDLLTHEWTDGIFSSFIRAGAI- 1936

Query: 1918 NTPKNTKKDIDLRLKSRISDLSNVFKLDSSDTTETDDNIFEEIEKVVKIPENHNFDWQWI 1977
                                        +SDT +                       +W 
Sbjct: 1937 ----------------------------TSDTNK-----------------------KWY 1945

Query: 1978 ILDGPVDTFWVENLNSVLDDTRTLCLANSERIALTNKIRVIFEVDNLSQASPATVSRCAM 2037
            + DGPVD  W+EN+N+VLDD + LCL++ E I LT  + ++FEV +L+ ASPATVSRC M
Sbjct: 1946 MFDGPVDAIWIENMNTVLDDNKKLCLSSGEIIKLTEAMTMMFEVQDLAVASPATVSRCGM 2005

Query: 2038 VYMDPVDLGWEPYVKSWLLKTSKIISQSGVDCLEFMIKNSVTDGLQFIRNRQKFQPYPME 2097
            VY++P  LG  P+++ WL K   ++ +   +  + +  + + + + F+R+  K +     
Sbjct: 2006 VYLEPSILGLMPFIECWLRKLPPLL-KPYEEHFKALFVSFLEESISFVRSSVK-EVIAST 2063

Query: 2098 DITVVITLCRILDAFF-DFMGKNG 2120
            +  + ++L ++LD FF  F+ + G
Sbjct: 2064 NCNLTMSLLKLLDCFFKPFLPREG 2087



 Score =  152 bits (383), Expect = 9e-36
 Identities = 92/260 (35%), Positives = 135/260 (51%), Gaps = 15/260 (5%)

Query: 2415 KLLKNNDHKGVVVSTINFSTNVTAAKTKEMILKKLIRRTKDTLGAPKNNRILIFIDDMNM 2474
            KLLKN      +   + FS   +A +T++ I  KL +R K   G P     + FIDD+NM
Sbjct: 2240 KLLKNLA-LDYISHFLTFSARTSANQTQDFIDSKLDKRRKGVFGPPLGRNFIFFIDDLNM 2298

Query: 2475 PVSDMYGAQPPLELIRQLLDLGGVYDTE-KNTWKNIQDLSIVAACVPV---VNDISPRLL 2530
            P  + YGAQPP+EL+RQ +D GG YD +    +KN+ D++ V A  P     N ++PRL+
Sbjct: 2299 PALETYGAQPPIELLRQWMDHGGWYDRKIIGAFKNLVDINFVCAMGPPGGGRNTVTPRLM 2358

Query: 2531 KHFSMLVLPHPSQDILCTIFQAHLG----------IYFSINNFTPEVQKSKDQIISCSLA 2580
            +HF+ L      +     IF   LG           Y       P +    + ++  ++ 
Sbjct: 2359 RHFNYLSFAEMDEVSKKRIFSTILGNWLDGLLGEKSYRERVPGAPHIAHFTEPLVEATIM 2418

Query: 2581 IYHQVRQNMLPTPTKCHYMFNLRDMFKLLLGLLQADRTVVNSKEMAALLFVHEATRVFHD 2640
            +Y  +   +LPTP K HY FNLRD+ K+  G+L AD   V  +     L+ HE  RVF D
Sbjct: 2419 VYATITSQLLPTPAKSHYTFNLRDLSKVFQGMLMADPAKVEDQVQLLRLWYHENCRVFRD 2478

Query: 2641 RLIDFTDKSLFYRLLSRELE 2660
            RL++  D+S F +LL R +E
Sbjct: 2479 RLVNEEDRSWFDQLLKRCME 2498



 Score = 40.4 bits (93), Expect = 0.040
 Identities = 22/60 (36%), Positives = 29/60 (48%)

Query: 2293 SGGNFLKITECGECINYTATRDTTCLSFLMSLLLKNSCPVLLTGESGVGKTAAINQMLEK 2352
            S   F  + +   C     T DT  +S L+ +LL N  PVL  G +G GKT  I+  L K
Sbjct: 2184 SSAPFTMVPDTNYCNIIVPTMDTVQMSHLLDMLLTNKKPVLCIGPTGTGKTLTISDKLLK 2243


>gi|151301127 dynein, axonemal, heavy chain 7 [Homo sapiens]
          Length = 4024

 Score =  937 bits (2421), Expect = 0.0
 Identities = 594/1892 (31%), Positives = 955/1892 (50%), Gaps = 227/1892 (11%)

Query: 2653 RLLSRELENCFQIGIDGCGKKTCATLACYLTDNKLYRVPISHKCAYIEFKEVFKKVFIHA 2712
            R+L +   +   +G+ G G+++   LA ++ D  +++V IS      E+ E  K +    
Sbjct: 2328 RILKQPRSHALLVGVGGSGRQSVTRLAAHMADYSVFQVEISKGYDTTEWHEDLKVILRKC 2387

Query: 2713 GLKGKPTVLMVPNLNIEQDSFLEDLNYIISSGRIPDLFENVELDSIAMKIRYLTEQSGHM 2772
                   V +  +  I+++SFLED++ ++++G IP+LF   E   I  K+R L  Q    
Sbjct: 2388 AEGEMQGVFLFTDTQIKEESFLEDVSNLLNAGEIPNLFALDEKQEICDKMRQLDRQRDKT 2447

Query: 2773 DNRQ----SLLSFFQKRIYKNLHIFVIMSPEGPSFRQNCRVYPSMISSCTIDWYERWPEE 2828
                    +L + F       LH+ + MSP G +FR   R +P++++ CTIDW++ WPE+
Sbjct: 2448 KQTDGSPIALFNMFIDHCRSQLHVVLAMSPIGDAFRNRLRKFPALVNCCTIDWFQSWPED 2507

Query: 2829 ALLIVANSFLKEKVNFENRENLKEKLAPTCVQIHKSMKDLNRKYFEETGRFYYTTPNSYL 2888
            AL  VA+ FL+E    E  E +++     C   H S  DL++ +F E  R+ Y TP SYL
Sbjct: 2508 ALQAVASRFLEE---IEMSEEIRDGCIDMCKSFHTSTIDLSKSFFVELQRYNYVTPTSYL 2564

Query: 2889 QFMETFAHILRAREEEMQTKRDRFHMGLSTILEATTLVTEMQEELLILGPQVEQKTKETE 2948
            + + TF  +L  +  E+   + R+ +GL  +  A++ V  MQ EL  L PQ++  +KE +
Sbjct: 2565 ELISTFKLLLEKKRSEVMKMKKRYEVGLEKLDSASSQVATMQMELEALHPQLKVASKEVD 2624

Query: 2949 TLMEKLRKDSQVVEKVQMLVKQDEEIVAEEVRIVEDYAQKTANELKSVLPAFDKAIVALN 3008
             +M  + K+S  V K + +VK DE I  E+    +    +   +L   LP  + A+ AL+
Sbjct: 2625 EMMIMIEKESVEVAKTEKIVKADETIANEQAMASKAIKDECDADLAGALPILESALAALD 2684

Query: 3009 ALDKADVAELRVYTRPPFLVLTVMNAVCILLQKKPN---------------WATAKLLLS 3053
             L   D+  ++    PP  V  VM A+CIL   K +               W  AK LL 
Sbjct: 2685 TLTAQDITVVKSMKSPPAGVKLVMEAICILKGIKADKIPDPTGSGKKIEDFWGPAKRLLG 2744

Query: 3054 ETGFLKKLINLDKDSIPDKVFVKLKK-IVTLPDFNPHKISLVSVACCSLCQWVIALNNYH 3112
            +  FL+ L   DKD+IP      ++K  +  PDF P KI   S A   LC+WVIA+++Y 
Sbjct: 2745 DMRFLQSLHEYDKDNIPPAYMNIIRKNYIPNPDFVPEKIRNASTAAEGLCKWVIAMDSYD 2804

Query: 3113 EVQKVVGPKQIQVAEAQNVLKIARQRLAEKQRGLQLVEEHLLFLQAAYKDTVAEKQLLAN 3172
            +V K+V PK+I++A A+  LKIA   L +KQ  L+ V++ L  LQ   +    +K  L N
Sbjct: 2805 KVAKIVAPKKIKLAAAEGELKIAMDGLRKKQAALKEVQDKLARLQDTLELNKQKKADLEN 2864

Query: 3173 RKTMASRRFQCASVLLTVLEDEKTRWQETINQIDNKLEGILGDILLSAACIVYSGILTPE 3232
            +  + S++ + A  L+  L  EKTRW  T  ++      + GDIL+S+  + Y G  T  
Sbjct: 2865 QVDLCSKKLERAEQLIGGLGGEKTRWSHTALELGQLYINLTGDILISSGVVAYLGAFTST 2924

Query: 3233 FRQLIVNKWETFCIENGISLSSKFSLIKVMAQKYEISRWHNQGLPHGQYSVENAILIKNG 3292
            +RQ    +W T C    I  S   SL+  + +   I  W+  GLP   +S++N I+I N 
Sbjct: 2925 YRQNQTKEWTTLCKGRDIPCSDDCSLMGTLGEAVTIRTWNIAGLPSDSFSIDNGIIIMNA 2984

Query: 3293 QQWPLLIDPHRQAHKWIRQME-GSRLQKLSIEDSNYTKKIENAMKTGGSVLLQNLLETLA 3351
            ++WPL+IDP  QA+KWI+ ME  + L  + + + +Y + +EN ++ G  VLL+N+ E L 
Sbjct: 2985 RRWPLMIDPQSQANKWIKNMEKANSLYVIKLSEPDYVRTLENCIQFGTPVLLENVGEELD 3044

Query: 3352 PGLKAILKKDIYQKKGHYFIRVGDAEFEYNSNFRLYLSTEIDNPHFLPSVYNFVTMINFT 3411
            P L+ +L K  +++ G   IR+GD+  EY  +FR Y++T++ NPH+LP     VT++NF 
Sbjct: 3045 PILEPLLLKQTFKQGGSTCIRLGDSTIEYAPDFRFYITTKLRNPHYLPETSVKVTLLNFM 3104

Query: 3412 VTFQGLQDQLLSTVVTHEVPHLEDQRSKLLESISLDAITLEELEEKTLNLLQKALGSILD 3471
            +T +G+QDQLL  VV  E P LE+++  L+   + +   L+E+E+K L +L  + G+IL+
Sbjct: 3105 ITPEGMQDQLLGIVVAQERPDLEEEKQALILQGAENKRQLKEIEDKILEVLSSSEGNILE 3164

Query: 3472 DDKIVDTLRKSKMTSNEISKRIEATKKAESEIQAIRKNYLPIATRGALLYFLVADLTQIN 3531
            D+  +  L  SK  +NEIS++ E  ++ E +I   R  Y PIA   ++L+F +ADL  I 
Sbjct: 3165 DETAIKILSSSKALANEISQKQEVAEETEKKIDTTRMGYRPIAIHSSILFFSLADLANIE 3224

Query: 3532 YMYQFSLDWFHQVFVSSVVSKSKEQEHSFKREKVSPKEVHEFISISKEPNLENEKNLLDK 3591
             MYQ+SL WF  +F+ S+ +  K +                               +L K
Sbjct: 3225 PMYQYSLTWFINLFILSIENSEKSE-------------------------------ILAK 3253

Query: 3592 HIKSAIDMLTKSIFKVVSSALFNEDKLCFSFRLCTVIMQNNANGNLIQDDIGFLPEEEWN 3651
             ++   D  T S++  V  +LF +DKL FSF  C  I       NL+  +   + + EW 
Sbjct: 3254 RLQILKDHFTYSLYVNVCRSLFEKDKLLFSF--CLTI-------NLLLHERA-INKAEWR 3303

Query: 3652 IFLYSGILINIKSALSQSRLTSTFEIGESQHLQWLSDSRWRQCQYVSTHLEPFSLLCKSL 3711
              L  GI ++   A                   WL    W +             +C+  
Sbjct: 3304 FLLTGGIGLDNPYA---------------NLCTWLPQKSWDE-------------ICR-- 3333

Query: 3712 LSNVSQWDTFKNSKAVYSLISTPFSSENASLEENTKP-PEETELLNENKETCNPINFPWE 3770
               +     FK  +  +  +   +     SLE + +  PEE E                +
Sbjct: 3334 ---LDDLPAFKTIRREFMRLKDGWKKVYDSLEPHHEVFPEEWE----------------D 3374

Query: 3771 KLTSFQRLILVKVLRPESLNNSVRKFITEKMGNKYLQRTGVNLKDAYKGSNARTPLILIQ 3830
            K   FQR+++++ LRP+ +   +++FI  ++G  +++    +L  A+  SN   PLI + 
Sbjct: 3375 KANEFQRMLIIRCLRPDKVIPMLQEFIINRLGRAFIEPPPFDLAKAFGDSNCCAPLIFVL 3434

Query: 3831 THGIDLTNILLRFAQELKGTTHHVTIISLGRDQAAKAEDLILKALTKTQQWVFLQNCHLA 3890
            + G D    LL+FA +       ++ +SLG+ Q   A  ++ KA+ K   WV LQNCHLA
Sbjct: 3435 SPGADPMAALLKFADDQGYGGSKLSSLSLGQGQGPIAMKMLEKAV-KEGTWVVLQNCHLA 3493

Query: 3891 TSFMPRLCTIVESFNSPNVTIDPEFRLWLSSKSYSSFPIPVLKKGLKIAVESPQGLKSNL 3950
            TS+MP L  + E   SP  T  P+FR+WL+S    +FP+ VL+ G+K+  E+P+GL++N+
Sbjct: 3494 TSWMPTLEKVCEEL-SPEST-HPDFRMWLTSYPSPNFPVSVLQNGVKMTNEAPKGLRANI 3551

Query: 3951 LQTFGCTGSGEVTEEIFENPDCGQWWKKLLFSLCFFNAVINERKNYGILGWNIAYKFNSS 4010
            ++++      +   E F +    + +KKLL+ LCFF+A++ ER+ +G LGWNI Y+FN +
Sbjct: 3552 IRSYLMDPISD--PEFFGSCKKPEEFKKLLYGLCFFHALVQERRKFGPLGWNIPYEFNET 3609

Query: 4011 DLGVAIKVLENSLRGQPSISWQALRYLIGEVIYGGRVIDNWDKRCLKTLLYKFCNPEVLK 4070
            DL ++++ L   L     + ++ALRY+ GE  YGGRV D+WD+R L+++L KF NPE+++
Sbjct: 3610 DLRISVQQLHMFLNQYEELPYEALRYMTGECNYGGRVTDDWDRRTLRSILNKFFNPELVE 3669

Query: 4071 D-DFSFSR--------SASIKDYIHIIQSLPDDDLPEVLGIHPEAIRSCWETQGEKFIEN 4121
            + D+ F          S   K YI   ++LP    PE+ G++  A  +  +++ +   +N
Sbjct: 3670 NSDYKFDSSGIYFVPPSGDHKSYIEYTKTLPLTPAPEIFGMNANADITKDQSETQLLFDN 3729

Query: 4122 LIAMQPKTTTANLMIRPEQSKDELVMEILSDLLKRLPLTVEKEEIAVGTPSTLKSMMSSS 4181
            ++  Q ++  A       +S DE+V E+ SD+L +LP   + E      P+T    M+  
Sbjct: 3730 ILLTQSRSAGAG-----AKSSDEVVNEVASDILGKLPNNFDIEAAMRRYPTTYTQSMN-- 3782

Query: 4182 IWESLSKNLKDHDPLIHCVLLTFLKQEIKRFDKLLFVIHKSLKDLQLAIKGEIILTQELE 4241
                                 T L QE+ RF+KLL  I  S  ++Q AIKG  +++ +LE
Sbjct: 3783 ---------------------TVLVQEMGRFNKLLKTIRDSCVNIQKAIKGLAVMSTDLE 3821

Query: 4242 EIFNSFLNMRVPTLWQKHAYRSCKPLSSWIDDLIQRLNFFNTWAKVAYTAIQRRYMRFVT 4301
            E+ +S LN+++P +W   +Y S KPL S+++D + RL F   W +V              
Sbjct: 3822 EVVSSILNVKIPEMWMGKSYPSLKPLGSYVNDFLARLKFLQQWYEV-------------- 3867

Query: 4302 VWKQSIPSTSQKCKHPEDSENNFFEGFPSRYWLPAFFFPQAFLAAVLQDYGRSRGIAVDA 4361
                                     G P  +WL  FFF QAFL    Q+Y R   I +D 
Sbjct: 3868 -------------------------GPPPVFWLSGFFFTQAFLTGAQQNYARKYTIPIDL 3902

Query: 4362 LTFTHHVISNTTDKDEKFSVFMPKKLNIVRRAFKGSASSHTGVYIFGLFIEGARWNREQK 4421
            L F + V+    DK+ K                        GV+I GLF++GA WNR+ K
Sbjct: 3903 LGFDYEVME---DKEYKH-------------------PPEDGVFIHGLFLDGASWNRKIK 3940

Query: 4422 ILEDSLPLEMCCDFPDIYFLPTKISTKTPNASNQTDSELYAFECPVYQTPERSRILATTG 4481
             L +S P  +    P ++  P K +      S         +  P+Y+T ER  +L+TTG
Sbjct: 3941 KLAESHPKILYDTVPVMWLKPCKRADIPKRPS---------YVAPLYKTSERRGVLSTTG 3991

Query: 4482 LPTNFLTSVYLSTKKPPSHWITMRVALLCEKN 4513
              TNF+ ++ L + +P  HWI   VALLC+ N
Sbjct: 3992 HSTNFVIAMTLPSDQPKEHWIGRGVALLCQLN 4023



 Score =  719 bits (1857), Expect = 0.0
 Identities = 440/1227 (35%), Positives = 647/1227 (52%), Gaps = 139/1227 (11%)

Query: 992  IEGDLTLRKKLWEAQEEWKRASWEWRNSSLQSIDVESVQRNVSKLMHIISVLEKGLPKSD 1051
            I+  L    +L+E   E+      W       ++ + V+ ++      +  LEK    S 
Sbjct: 759  IQDGLNPYLRLYETAVEFSSNYRAWTEGPYHKVNPDQVEADIGNYWRGLYKLEKTFHDSP 818

Query: 1052 ----MVTHLKQVVTEFKQELPIIIALGNPCLKPRHWEALQEIIGKSVPLDKNCKVENLLA 1107
                M   ++  V +FKQ +P+I  + NP L+PRHWEA+  I+G  +    +  V + L 
Sbjct: 819  YALAMTKKVRSKVEDFKQHIPLIQVICNPGLRPRHWEAMSAIVGYPLQPSDDSTVSSFLD 878

Query: 1108 LKMFQYENEINDMSTSATNEAALEKMLFKIIDFWNTTPLPLILHHTEIYSIFIIPSIDDI 1167
            + +  Y +    +S +A+ E +LEK + K+I  W+   +  ++H       FI+ S+D+I
Sbjct: 879  MNLEPYIDRFEGISEAASKEYSLEKAMEKMITEWDA--VEFVIHSYRETGTFILASVDEI 936

Query: 1168 SAQLEESQVILATIKGSPHIGPIKDLVNEWDQNLTLFSYTLEEWMNCQRNWLYLEPVFHS 1227
               L++  +   T++GSP I P +  + EW+  L L    L+EW+  Q  WLYLEP+F S
Sbjct: 937  QMLLDDHIIKTQTMRGSPFIKPYEKQMREWEGKLLLLQEILDEWLKVQATWLYLEPIFSS 996

Query: 1228 SEIRRQLPAETELFSQVISMWKKIMSKIQNKQNALQITTSAGVLEILQNCNIHLEHIKKS 1287
             +I  Q+P E   F+ V   W+ IM  +   ++ L + T   +LE L+  N  LE I K 
Sbjct: 997  PDIMSQMPEEGRRFTAVDKTWRDIMRSVMQDKHVLTVVTIDRMLERLKKSNELLELILKG 1056

Query: 1288 LEDYLEVKRLIFPRFYFLSNAELLDILADSRNPESVQPHLVKCFENIKQLLIWKQDIGPP 1347
            L +YLE KRL FPRF+FLSN ELL+IL+++++P  VQPHL KCFE I ++   +      
Sbjct: 1057 LNEYLEKKRLFFPRFFFLSNDELLEILSETKDPTRVQPHLKKCFEGIAKVEFTET----L 1112

Query: 1348 AVKMLISAEGEGLVLPKKI---RVRSAVEQWLVNVEKSMFDVLKKERYIYNIILLFQSQI 1404
             +  + S+EGE + L + I   + R  VE+WLV +E+ M + + K             +I
Sbjct: 1113 DITHMKSSEGEVVELIEIISTAKARGQVEKWLVELERVMINSIHKVTGDATFAYTKYERI 1172

Query: 1405 MFYND-------CVKSFVSSYSREKLEKVHAGLM--------CHLEEVADLVVLDTS--N 1447
             +  D       CV      +++E    +  G+         C+  ++ D+V L     +
Sbjct: 1173 NWVRDWPGQTVLCVSQIF--WTKEVQTAIPMGIKALEQYLKTCN-RQIDDIVTLVRGKLS 1229

Query: 1448 SRTKAILGALLILYVHCRDIVINLLLKNIFNAEDFEWTRHLQYKWNEKQKLCYVSQGNAS 1507
             + +  LGAL++L VH RD++ +L+ KNI +  DFEW   L+Y W E          NA 
Sbjct: 1230 MQNRVTLGALVVLDVHARDVLSSLVKKNISDDSDFEWLSQLRYYWQENH--LETKMINAG 1287

Query: 1508 FTYGYEYLGCTSRLVITPLTDRCWLTLMEALHLNLGGCPAGPAGTGKTETVKDLAKSLGK 1567
              YGYEYLG + RLVITPLTDRC+ TL  ALHL+LGG P GPAGTGKTET KDLAK++ K
Sbjct: 1288 LRYGYEYLGNSPRLVITPLTDRCYRTLFGALHLHLGGAPEGPAGTGKTETTKDLAKAVAK 1347

Query: 1568 HCVVFNCFEDLDYKIVRKFFFGLVQSGAWSCFDEFNLIDLEVLSVIASQILTIKAAKDNY 1627
             CVVFNC + LDY  + KFF GL+  GAW+CFDEFN IDLEVLSV+A QILTI+   +  
Sbjct: 1348 QCVVFNCSDGLDYLALGKFFKGLLSCGAWACFDEFNRIDLEVLSVVAQQILTIQRGINAG 1407

Query: 1628 SARFVLEGKEIRINMSCAVFITMNPRYGGGVELPDNLKSLFRPVAMMVPHYQMIAEIILF 1687
            +   + EG E++++ +CAVFITMNP Y G  ELPDNLK+LFR VAMMVP Y MIAEI+L+
Sbjct: 1408 ADILMFEGTELKLDPTCAVFITMNPGYAGRSELPDNLKALFRTVAMMVPDYAMIAEIVLY 1467

Query: 1688 SFGFKSANSLSGKLTNLYELARKQLSQQDHYNFGLRSLKIVLIMAGTKKREFKCLSEADE 1747
            S GF +A  LS K+   Y L  +QLS Q HY++G+R++K VL  AG  K ++      +E
Sbjct: 1468 SCGFVTARPLSVKIVATYRLCSEQLSSQHHYDYGMRAVKSVLTAAGNLKLKY---PNENE 1524

Query: 1748 TLIVIEAIREASLPKCPPEDVPLFENIIGDIFPEVTVLKVNQLALEKVIYTATQQLGLQN 1807
             ++++ +I + +LPK    D+PLFE I  D+FP V + K +   L   I      + LQ 
Sbjct: 1525 EILLLRSIIDVNLPKFLSHDLPLFEGITSDLFPGVKLPKPDYNDLLAAIKDNCASMNLQM 1584

Query: 1808 WSSQKEKIIQFYNQLQVCVGVMLVGPTGGGKTTVRRILEKALTLLPIADFLSVAERKSAS 1867
             +   EKI+Q Y  + V  G M+VG   GGKT+  R+L  AL  +               
Sbjct: 1585 TAFFSEKILQVYEMMIVRHGFMIVGEPFGGKTSAYRVLAGALNDI-------------CE 1631

Query: 1868 KISERKGKVDICVLNPKCVTLSELYGQLDPNTMEWTDGLLSATIRSYVYFNTPKNTKKDI 1927
            K    + KV I VLNPK VT+ +LYGQ D  + EW+DG+L+ + R++    TP       
Sbjct: 1632 KGLMEENKVQITVLNPKSVTMGQLYGQFDSVSHEWSDGVLAVSFRAFASSVTP------- 1684

Query: 1928 DLRLKSRISDLSNVFKLDSSDTTETDDNIFEEIEKVVKIPENHNFDWQWIILDGPVDTFW 1987
                                                         D +W+I DGPVD  W
Sbjct: 1685 ---------------------------------------------DRKWLIFDGPVDAVW 1699

Query: 1988 VENLNSVLDDTRTLCLANSERIALTNKIRVIFEVDNLSQASPATVSRCAMVYMDPVDLGW 2047
            +EN+N+VLDD + LCL + E I ++ ++ +IFE  +L  ASPATVSRC M+YM+P  LGW
Sbjct: 1700 IENMNTVLDDNKKLCLMSGEIIQMSPQMNLIFEPMDLEVASPATVSRCGMIYMEPHMLGW 1759

Query: 2048 EPYVKSWLLKTSKIISQSGVDCLEFMIKNSVTDGLQFIRNRQKFQPYPMEDITVVITLCR 2107
             P + SW+      +S    + +  +    V   ++FIR   K +  P  D  +V +L  
Sbjct: 1760 RPLMLSWVNLLPASVSVIQKEFIMGLFDRMVPVSVEFIRKHTK-ELSPTSDTNLVRSLMN 1818

Query: 2108 ILDAFFDFMGKNGGFEQSDDLNDTSSKEANSQRESVTFKDIEKRDENTWYPEKNPDKLTK 2167
            ++D F D           D  ++   KE N              D  T+           
Sbjct: 1819 LIDCFMD-----------DFADEVKLKERN--------------DRETY----------S 1843

Query: 2168 IIQKLFVFAFTWAFGGALNREDEHREN 2194
            +++ +F+F+  W+ G +   +D  + N
Sbjct: 1844 LLEGIFLFSLIWSVGASCTDDDRLKFN 1870



 Score =  167 bits (424), Expect = 2e-40
 Identities = 99/297 (33%), Positives = 160/297 (53%), Gaps = 15/297 (5%)

Query: 2369 DTLLYSEIKKSSSLKQNITILIPETHKTATGSSDNPTKKPEVRTNKKLLKNNDHKGVVVS 2428
            DT+ YS + +  +  Q  +I +  T    TG S   T     + NK++ K          
Sbjct: 1954 DTIRYSALMELLTTHQKPSIFVGPT---GTGKSVYITNFLLNQLNKEIYKP--------L 2002

Query: 2429 TINFSTNVTAAKTKEMILKKLIRRTKDTLGAPKNNRILIFIDDMNMPVSDMYGAQPPLEL 2488
             INFS   TAA+T+ +++ KL +R K   G P   R+++F+DD+NMP  ++YGAQPP+EL
Sbjct: 2003 LINFSAQTTAAQTQNIVMSKLDKRRKGVFGPPLGKRMVVFVDDVNMPAREVYGAQPPIEL 2062

Query: 2489 IRQLLDLGGVYDTEKNTWKNIQDLSIVAACVPV---VNDISPRLLKHFSMLVLPHPSQDI 2545
            +RQ LD    YD +  +   + D+ I+ A  P     N ++PR ++HF+++ +   S   
Sbjct: 2063 LRQWLDHWNWYDLKDCSMIKLVDIQIMCAMGPPGGGRNPVTPRYMRHFNIITINEFSDKS 2122

Query: 2546 LCTIFQAHLGIYFSI-NNFTPEVQKSKDQIISCSLAIYHQVRQNMLPTPTKCHYMFNLRD 2604
            + TIF   L  +  I   F  E      QI++ ++ +Y +  +N+LPTP K HY+FNLRD
Sbjct: 2123 MYTIFSRILTWHLEICYKFPDEFLDLTTQIVNGTMTLYKEAMKNLLPTPAKSHYLFNLRD 2182

Query: 2605 MFKLLLGLLQADRTVVNSKEMAALLFVHEATRVFHDRLIDFTDKSLFYRLLSRELEN 2661
              +++ G+  +      + E+   L+VHE  RV++DRL+D TD+S     +   L N
Sbjct: 2183 FSRVIQGVCLSRPETTETTEVIKRLWVHEVLRVYYDRLLDNTDRSWLINYIQEILRN 2239


>gi|24308169 dynein, axonemal, heavy chain 3 [Homo sapiens]
          Length = 4116

 Score =  924 bits (2389), Expect = 0.0
 Identities = 578/1888 (30%), Positives = 952/1888 (50%), Gaps = 224/1888 (11%)

Query: 2653 RLLSRELENCFQIGIDGCGKKTCATLACYLTDNKLYRVPISHKCAYIEFKEVFKKVFIHA 2712
            R+L ++  +   +GI G G+++ A L+ ++   +LY++ I+   A  +++E  KK+ +  
Sbjct: 2421 RVLKQDKGHLLLVGIGGSGRQSAAKLSTFMNAYELYQIEITKNYAGNDWREDLKKIILQV 2480

Query: 2713 GLKGKPTVLMVPNLNIEQDSFLEDLNYIISSGRIPDLFENVELDSIAMKIRYLTEQSGHM 2772
            G+  K TV +  +  I+ +SF+ED+N ++++G +P++F   E   I  K++      G  
Sbjct: 2481 GVATKSTVFLFADNQIKDESFVEDINMLLNTGDVPNIFPADEKADIVEKMQTAARTQGEK 2540

Query: 2773 DNRQ--SLLSFFQKRIYKNLHIFVIMSPEGPSFRQNCRVYPSMISSCTIDWYERWPEEAL 2830
                  S+ +FF +R+   +   + MSP G +FR   R++PS+I+ CTIDW++ WP +AL
Sbjct: 2541 VEVTPLSMYNFFIERVINKISFSLAMSPIGDAFRNRLRMFPSLINCCTIDWFQSWPTDAL 2600

Query: 2831 LIVANSFLKEKVNFENRENLKEKLAPTCVQIHKSMKDLNRKYFEETGRFYYTTPNSYLQF 2890
             +VAN FL++    E  +N++ ++   C    +S+K L+  Y+ +  R  Y TP SYL+ 
Sbjct: 2601 ELVANKFLED---VELDDNIRVEVVSMCKYFQESVKKLSLDYYNKLRRHNYVTPTSYLEL 2657

Query: 2891 METFAHILRAREEEMQTKRDRFHMGLSTILEATTLVTEMQEELLILGPQVEQKTKETETL 2950
            + TF  +L ++ +E+   R+R+  GL  +  A + V  MQ EL  L PQ+   ++ET  +
Sbjct: 2658 ILTFKTLLNSKRQEVAMMRNRYLTGLQKLDFAASQVAVMQRELTALQPQLILTSEETAKM 2717

Query: 2951 MEKLRKDSQVVEKVQMLVKQDEEIVAEEVRIVEDYAQKTANELKSVLPAFDKAIVALNAL 3010
            M K+  +++  +  ++LV+ DE+       I +    +   +L   +PA + A+ AL+ L
Sbjct: 2718 MVKIEAETREADGKKLLVQADEKEANVAAAIAQGIKNECEGDLAEAMPALEAALAALDTL 2777

Query: 3011 DKADVAELRVYTRPPFLVLTVMNAVCILLQKKPN---------------WATAKLLLSET 3055
            + AD++ ++    PP  V  VM ++CI+   KP                W  +K +L + 
Sbjct: 2778 NPADISLVKSMQNPPGPVKLVMESICIMKGMKPERKPDPSGSGKMIEDYWGVSKKILGDL 2837

Query: 3056 GFLKKLINLDKDSIPDKVFVKLK-KIVTLPDFNPHKISLVSVACCSLCQWVIALNNYHEV 3114
             FL+ L   DKD+IP     +++ + +  P+F P  I  VS AC  LC+WV A+  Y  V
Sbjct: 2838 KFLESLKTYDKDNIPPLTMKRIRERFINHPEFQPAVIKNVSSACEGLCKWVRAMEVYDRV 2897

Query: 3115 QKVVGPKQIQVAEAQNVLKIARQRLAEKQRGLQLVEEHLLFLQAAYKDTVAEKQLLANRK 3174
             KVV PK+ ++ EA+  L    Q+L +K+  L+LV + L  L   +++   +K+ L    
Sbjct: 2898 AKVVAPKRERLREAEGKLAAQMQKLNQKRAELKLVVDRLQALNDDFEEMNTKKKDLEENI 2957

Query: 3175 TMASRRFQCASVLLTVLEDEKTRWQETINQIDNKLEGILGDILLSAACIVYSGILTPEFR 3234
             + S++   A  L++ L  EK RW E   Q+  +   + GD+LLS+  + Y G  T ++R
Sbjct: 2958 EICSQKLVRAEKLISGLGGEKDRWTEAARQLGIRYTNLTGDVLLSSGTVAYLGAFTVDYR 3017

Query: 3235 QLIVNKWETFCIENGISLSSKFSLIKVMAQKYEISRWHNQGLPHGQYSVENAILIKNGQQ 3294
                N+W   C +  I   S FSL   +    +I  W   GLP   +S++N I++ N ++
Sbjct: 3018 VQCQNQWLAECKDKVIPGFSDFSLSHTLGDPIKIRAWQIAGLPVDSFSIDNGIIVSNSRR 3077

Query: 3295 WPLLIDPHRQAHKWIRQME-GSRLQKLSIEDSNYTKKIENAMKTGGSVLLQNLLETLAPG 3353
            W L+IDPH QA+KWI+ ME  ++L  +   DSNY + +ENA++ G  VL++N+ E L   
Sbjct: 3078 WALMIDPHGQANKWIKNMEKANKLAVIKFSDSNYMRMLENALQLGTPVLIENIGEELDAS 3137

Query: 3354 LKAILKKDIYQKKGHYFIRVGDAEFEYNSNFRLYLSTEIDNPHFLPSVYNFVTMINFTVT 3413
            ++ IL K  ++++G  ++R+G+   EY+ +F+LY++T + NPH+LP V   V ++NF +T
Sbjct: 3138 IEPILLKATFKQQGVEYMRLGENIIEYSRDFKLYITTRLRNPHYLPEVAVKVCLLNFMIT 3197

Query: 3414 FQGLQDQLLSTVVTHEVPHLEDQRSKLLESISLDAITLEELEEKTLNLLQKALGSILDDD 3473
              GLQDQLL  V   E P LE+++++L+   + +   L+E+E+K L +L  + G+IL+D+
Sbjct: 3198 PLGLQDQLLGIVAAKEKPELEEKKNQLIVESAKNKKHLKEIEDKILEVLSMSKGNILEDE 3257

Query: 3474 KIVDTLRKSKMTSNEISKRIEATKKAESEIQAIRKNYLPIATRGALLYFLVADLTQINYM 3533
              +  L  SK+ S EIS++ +     E++I   R  Y P+A   A ++F ++DL  I  M
Sbjct: 3258 TAIKVLSSSKVLSEEISEKQKVASMTETQIDETRMGYKPVAVHSATIFFCISDLANIEPM 3317

Query: 3534 YQFSLDWFHQVFVSSVVSKSKEQEHSFKREKVSPKEVHEFISISKEPNLENEKNLLDKHI 3593
            YQ+SL WF  +++ S+   +K +E                               L+  I
Sbjct: 3318 YQYSLTWFINLYMHSLTHSTKSEE-------------------------------LNLRI 3346

Query: 3594 KSAIDMLTKSIFKVVSSALFNEDKLCFSFRLCTVIMQNNANGNLIQDDIGFLPEEEWNIF 3653
            K  ID  T SI+  V  +LF +DKL FS  L   IM+              + EE W   
Sbjct: 3347 KYIIDHFTLSIYNNVCRSLFEKDKLLFSLLLTIGIMKQKKE----------ITEEVWYFL 3396

Query: 3654 LYSGILINIKSALSQSRLTSTFEIGESQHLQWLSDSRWRQCQYVSTHLEPFSLLCKSLLS 3713
            L  GI ++                  +   QWLS+  W +    S  L     L + L  
Sbjct: 3397 LTGGIALD--------------NPYPNPAPQWLSEKAWAEIVRASA-LPKLHGLMEHLEQ 3441

Query: 3714 NVSQWDTFKNSKAVYSLISTPFSSENASLEENTKPPEETELLNENKETCNPINFPWEKLT 3773
            N+ +W      K +Y                ++  P E +L              W+   
Sbjct: 3442 NLGEW------KLIY----------------DSAWPHEEQLPGS-----------WKFSQ 3468

Query: 3774 SFQRLILVKVLRPESLNNSVRKFITEKMGNKYLQRTGVNLKDAYKGSNARTPLILIQTHG 3833
              +++++++ LRP+ +  +VR+FI E MG  Y++    +L+ +Y  S+   PLI + +  
Sbjct: 3469 GLEKMVILRCLRPDKMVPAVREFIAEHMGKLYIEAPTFDLQGSYNDSSCCAPLIFVLSPS 3528

Query: 3834 IDLTNILLRFAQELKGTTHHVTIISLGRDQAAKAEDLILKALTKTQQWVFLQNCHLATSF 3893
             D    LL+FA +L         ISLG+ Q   A  +I  A+ K   WV LQNCHLA S+
Sbjct: 3529 ADPMAGLLKFADDLGMGGTRTQTISLGQGQGPIAAKMINNAI-KDGTWVVLQNCHLAASW 3587

Query: 3894 MPRLCTIVESFNSPNVTIDPEFRLWLSSKSYSSFPIPVLKKGLKIAVESPQGLKSNLLQT 3953
            MP L  I E    P  T +  FRLWL+S     FP+ +L+ G+K+  E P+GL++NLL++
Sbjct: 3588 MPTLEKICEEVIVPEST-NARFRLWLTSYPSEKFPVSILQNGIKMTNEPPKGLRANLLRS 3646

Query: 3954 FGCTGSGEVTEEIFENPDCGQ--WWKKLLFSLCFFNAVINERKNYGILGWNIAYKFNSSD 4011
            +    +  +++ +F    C +   W+K+LF LCFF+AV+ ER+N+G LGWNI Y+FN SD
Sbjct: 3647 Y---LNDPISDPVFFQ-SCAKAVMWQKMLFGLCFFHAVVQERRNFGPLGWNIPYEFNESD 3702

Query: 4012 LGVAIKVLENSLRGQPSISWQALRYLIGEVIYGGRVIDNWDKRCLKTLLYKFCNPEVLKD 4071
            L +++  ++  L     + + AL YL GE  YGGRV D+ D+R L +LL  F   E+ +D
Sbjct: 3703 LRISMWQIQMFLNDYKEVPFDALTYLTGECNYGGRVTDDKDRRLLLSLLSMFYCKEIEED 3762

Query: 4072 DFSFSRS--------ASIKDYIHIIQSLPDDDLPEVLGIHPEAIRSCWETQGEKFIENLI 4123
             +S +           S + YI  +++LP    PEV G+H  A  +    +  +  E ++
Sbjct: 3763 YYSLAPGDTYYIPPHGSYQSYIDYLRNLPITAHPEVFGLHENADITKDNQETNQLFEGVL 3822

Query: 4124 AMQPKTTTANLMIRPEQSKDELVMEILSDLLKRLPLTVEKEEIAVGTPSTLKSMMSSSIW 4183
               P+ +  +      +S  E+V E+  D+L +LP   + EE+    P   +  M+    
Sbjct: 3823 LTLPRQSGGS-----GKSPQEVVEELAQDILSKLPRDFDLEEVMKLYPVVYEESMN---- 3873

Query: 4184 ESLSKNLKDHDPLIHCVLLTFLKQEIKRFDKLLFVIHKSLKDLQLAIKGEIILTQELEEI 4243
                               T L+QE+ RF++L  V+ +SL +L  AIKG+++++ ELEE+
Sbjct: 3874 -------------------TVLRQELIRFNRLTKVVRRSLINLGRAIKGQVLMSSELEEV 3914

Query: 4244 FNSFLNMRVPTLWQKHAYRSCKPLSSWIDDLIQRLNFFNTWAKVAYTAIQRRYMRFVTVW 4303
            FNS L  +VP +W   +Y S KPL  ++ DL+ RL FF  W                   
Sbjct: 3915 FNSMLVGKVPAMWAAKSYPSLKPLGGYVADLLARLTFFQEWID----------------- 3957

Query: 4304 KQSIPSTSQKCKHPEDSENNFFEGFPSRYWLPAFFFPQAFLAAVLQDYGRSRGIAVDALT 4363
                                  +G P  +W+  F+F Q+FL  V Q+Y R   I +D + 
Sbjct: 3958 ----------------------KGPPVVFWISGFYFTQSFLTGVSQNYARKYTIPIDHIG 3995

Query: 4364 FTHHVISNTTDKDEKFSVFMPKKLNIVRRAFKGSASSHTGVYIFGLFIEGARWNREQKIL 4423
            F   V    T  +                      +   G YI GLF+EGARW+R+   +
Sbjct: 3996 FEFEVTPQETVMEN---------------------NPEDGAYIKGLFLEGARWDRKTMQI 4034

Query: 4424 EDSLPLEMCCDFPDIYFLPTKISTKTPNASNQTDSELYAFECPVYQTPERSRILATTGLP 4483
             +SLP  +    P I+  P +       ++     ++Y   CPVY+T  R   L+TTG  
Sbjct: 4035 GESLPKILYDPLPIIWLKPGE-------SAMFLHQDIYV--CPVYKTSARRGTLSTTGHS 4085

Query: 4484 TNFLTSVYLSTKKPPSHWITMRVALLCE 4511
            TN++ S+ L T  P  HWI   VA LC+
Sbjct: 4086 TNYVLSIELPTDMPQKHWINRGVASLCQ 4113



 Score =  685 bits (1767), Expect = 0.0
 Identities = 456/1376 (33%), Positives = 684/1376 (49%), Gaps = 182/1376 (13%)

Query: 1000 KKLWEAQEEWKRASWEWRNSSLQSIDVESVQRNVSKLMH----IISVLEKGLPKSDMVTH 1055
            ++LW    E+   S EW N  L  ++ E +   +  +      +I  L        +  +
Sbjct: 870  EQLWSTAYEFSIKSEEWMNGPLFLLNAEQIAEEIGNMWRTTYKLIKTLSDVPAPRRLAEN 929

Query: 1056 LKQVVTEFKQELPIIIALGNPCLKPRHWEALQEIIGKSVPLDKNCKVENLLALKMFQYEN 1115
            +K  + +FKQ +PI+    NP +K RHW+ + EI+G  +   +   + N+L     ++  
Sbjct: 930  VKIKIDKFKQYIPILSISCNPGMKDRHWQQISEIVGYEIKPTETTCLSNMLEFGFGKFVE 989

Query: 1116 EINDMSTSATNEAALEKMLFKI-IDFWNTTPLPLILHHTEIYSIFIIPSIDDISAQLEES 1174
            ++  +  +A+ E +LEK L ++ +D+ N T   +    T+     I+ +IDDI   L++ 
Sbjct: 990  KLEPIGAAASKEYSLEKNLDRMKLDWVNVTFSFVKYRDTDTN---ILCAIDDIQMLLDDH 1046

Query: 1175 QVILATIKGSPHIGPIKDLVNEWDQNLTLFSYTLEEWMNCQRNWLYLEPVFHSSEIRRQL 1234
             +   T+ GSP I PI+    +W++ L      L+ W+ CQ  WLYLEP+F S +I  Q+
Sbjct: 1047 VIKTQTMCGSPFIKPIEAECRKWEEKLIRIQDNLDAWLKCQATWLYLEPIFSSEDIIAQM 1106

Query: 1235 PAETELFSQVISMWKKIMSKIQNKQNALQITTSAGVLEILQNCNIHLEHIKKSLEDYLEV 1294
            P E   F  V S WK +MS+       L       + E LQ  N  LE I+K L DYLE 
Sbjct: 1107 PEEGRKFGIVDSYWKSLMSQAVKDNRILVAADQPRMAEKLQEANFLLEDIQKGLNDYLEK 1166

Query: 1295 KRLIFPRFYFLSNAELLDILADSRNPESVQPHLVKCFENIKQLLIWKQDIGPPAVKMLIS 1354
            KRL FPRF+FLSN ELL+IL+++++P  VQPHL KCFE I +L    +      +  +IS
Sbjct: 1167 KRLFFPRFFFLSNDELLEILSETKDPLRVQPHLKKCFEGIAKL----EFTDNLEIVGMIS 1222

Query: 1355 AEGEGLVLPKKI---RVRSAVEQWLVNVEKSMFDVLKK------ERYIY----NIILLFQ 1401
            +E E +   +KI     +  VE+WL  VE+ M   +++      E Y+     + +L + 
Sbjct: 1223 SEKETVPFIQKIYPANAKGMVEKWLQQVEQMMLASMREVIGLGIEAYVKVPRNHWVLQWP 1282

Query: 1402 SQIMFYNDCVKSFVSSYSREKLEKVHAGLMCHL-----EEVADLVVLDTS--NSRTKAIL 1454
             Q++    CV S    +++E  + +    +        +++A +V L     +S  +  L
Sbjct: 1283 GQVVI---CVSSIF--WTQEVSQALAENTLLDFLKKSNDQIAQIVQLVRGKLSSGARLTL 1337

Query: 1455 GALLILYVHCRDIVINLLLKNIFNAEDFEWTRHLQYKWNEKQKLCYVSQGNASFTYGYEY 1514
            GAL ++ VH RD+V  L    + +  DF+W   L+Y W  K     +    A   YGYEY
Sbjct: 1338 GALTVIDVHARDVVAKLSEDRVSDLNDFQWISQLRYYWVAKDVQVQIITTEA--LYGYEY 1395

Query: 1515 LGCTSRLVITPLTDRCWLTLMEALHLNLGGCPAGPAGTGKTETVKDLAKSLGKHCVVFNC 1574
            LG + RLVITPLTDRC+ TLM AL LNLGG P GPAGTGKTET KDLAK+L K CVVFNC
Sbjct: 1396 LGNSPRLVITPLTDRCYRTLMGALKLNLGGAPEGPAGTGKTETTKDLAKALAKQCVVFNC 1455

Query: 1575 FEDLDYKIVRKFFFGLVQSGAWSCFDEFNLIDLEVLSVIASQILTIKAAKDNYSARFVLE 1634
             + LDYK + KFF GL Q+GAW+CFDEFN I++EVLSV+A QIL+I+ A       F+ E
Sbjct: 1456 SDGLDYKAMGKFFKGLAQAGAWACFDEFNRIEVEVLSVVAQQILSIQQAIIRKLKTFIFE 1515

Query: 1635 GKEIRINMSCAVFITMNPRYGGGVELPDNLKSLFRPVAMMVPHYQMIAEIILFSFGFKSA 1694
            G E+ +N +CAVFITMNP Y G  ELPDNLK+LFR VAMMVP Y +I EI L+S GF  +
Sbjct: 1516 GTELSLNPTCAVFITMNPGYAGRAELPDNLKALFRTVAMMVPDYALIGEISLYSMGFLDS 1575

Query: 1695 NSLSGKLTNLYELARKQLSQQDHYNFGLRSLKIVLIMAGTKKREFKCLSEADETLIVIEA 1754
             SL+ K+   Y L  +QLS Q HY++G+R++K VL  AG  K ++    E +E+++++ A
Sbjct: 1576 RSLAQKIVATYRLCSEQLSSQHHYDYGMRAVKSVLTAAGNLKLKY---PEENESVLLLRA 1632

Query: 1755 IREASLPKCPPEDVPLFENIIGDIFPEVTVLKVNQLALEKVIYTATQQLGLQNWSSQKEK 1814
            + + +L K   +DVPLF+ II D+FP V + K +     KV+    +++ LQ       K
Sbjct: 1633 LLDVNLAKFLAQDVPLFQGIISDLFPGVVLPKPDYEVFLKVLNDNIKKMKLQPVPWFIGK 1692

Query: 1815 IIQFYNQLQVCVGVMLVGPTGGGKTTVRRILEKALTLLPIADFLSVAERKSASKISERKG 1874
            IIQ Y  + V  G M+VG   GGKT+  ++L  AL            +  +A+++ E   
Sbjct: 1693 IIQIYEMMLVRHGYMIVGDPMGGKTSAYKVLAAAL-----------GDLHAANQMEE--F 1739

Query: 1875 KVDICVLNPKCVTLSELYGQLDPNTMEWTDGLLSATIRSYVYFNTPKNTKKDIDLRLKSR 1934
             V+  ++NPK +T+ +LYG  D  + EW DG+                            
Sbjct: 1740 AVEYKIINPKAITMGQLYGCFDQVSHEWMDGV---------------------------- 1771

Query: 1935 ISDLSNVFKLDSSDTTETDDNIFEEIEKVVKIPENHNFDWQWIILDGPVDTFWVENLNSV 1994
               L+N F+  +S  ++                     D +WII DGPVD  W+EN+N+V
Sbjct: 1772 ---LANAFREQASSLSD---------------------DRKWIIFDGPVDAIWIENMNTV 1807

Query: 1995 LDDTRTLCLANSERIALTNKIRVIFEVDNLSQASPATVSRCAMVYMDPVDLGWEPYVKSW 2054
            LDD + LCL + E I + +K+ +IFE  +L QASPATVSRC M+YM+P  LGW+P   S+
Sbjct: 1808 LDDNKKLCLMSGEIIQMNSKMSLIFEPADLEQASPATVSRCGMIYMEPHQLGWKPLKDSY 1867

Query: 2055 LLKTSKIISQSGVDCLEFMIKNSVTDGLQFIRNRQKFQPYPMEDITVVITLCRILDAFFD 2114
            +      +++   + +  M    V   L+F R   KF       I +  ++ R+  +  D
Sbjct: 1868 MDTLPSSLTKEHKELVNDMFMWLVQPCLEFGRLHCKF-VVQTSPIHLAFSMMRLYSSLLD 1926

Query: 2115 FMGKNGGFEQSDDLNDTSSKEANSQRESVTFKDIEKRDENTWYPEKNPDKLTKIIQKLFV 2174
             +                   A  + E    + +  +    W            +Q LF+
Sbjct: 1927 EI------------------RAVEEEEMELGEGLSSQQIFLW------------LQGLFL 1956

Query: 2175 FAFTWAFGGALNREDEHRENIPFCPSLEPDSLAKVTYDFDKLVHELFGNSSQVGWKHWGQ 2234
            F+  W   G +N                 DS  K    F  L+  +  N       H   
Sbjct: 1957 FSLVWTVAGTIN----------------ADSRKKFDVFFRNLIMGMDDN-------HPRP 1993

Query: 2235 SQGRRRKGNCINLPTGECSIFGYFVDIEQCEFIPWSDLVPNDQTLIQRGTSLLTNLQRSG 2294
               +  K N    P        YF+      +  W+  +  ++  +  G           
Sbjct: 1994 KSVKLTKNNI--FPERGSIYDFYFIKQASGHWETWTQYITKEEEKVPAGA---------- 2041

Query: 2295 GNFLKITECGECINYTATRDTTCLSFLMSLLLKNSCPVLLTGESGVGKTAAINQML 2350
                K++E         T +T   SF +   L +  P+L  G +G GK+A  N  L
Sbjct: 2042 ----KVSEL-----IIPTMETARQSFFLKTYLDHEIPMLFVGPTGTGKSAITNNFL 2088



 Score =  168 bits (425), Expect = 1e-40
 Identities = 104/346 (30%), Positives = 175/346 (50%), Gaps = 19/346 (5%)

Query: 2430 INFSTNVTAAKTKEMILKKLIRRTKDTLGAPKNNRILIFIDDMNMPVSDMYGAQPPLELI 2489
            INFS   +A +T+++I+ KL RR K   G P   + ++F+DD+NMP  ++YGAQPP+EL+
Sbjct: 2101 INFSARTSANQTQDIIMSKLDRRRKGLFGPPIGKKAVVFVDDLNMPAKEVYGAQPPIELL 2160

Query: 2490 RQLLDLGGVYDTEKNTWKNIQDLSIVAACVPV---VNDISPRLLKHFSMLVLPHPSQDIL 2546
            RQ +D G  +D +  T  +I D+ +V A  P     NDI+ R  +H +++ +     DIL
Sbjct: 2161 RQWIDHGYWFDKKDTTRLDIVDMLLVTAMGPPGGGRNDITGRFTRHLNIISINAFEDDIL 2220

Query: 2547 CTIFQAHLGIYFSINNFTPEVQKSKDQIISCSLAIYHQVRQNMLPTPTKCHYMFNLRDMF 2606
              IF + +  +F    F     +    ++  +  IY    +N LPTP+K HY+FNLRD  
Sbjct: 2221 TKIFSSIVDWHFG-KGFDVMFLRYGKMLVQATKTIYRDAVENFLPTPSKSHYVFNLRDFS 2279

Query: 2607 KLLLGLLQADRTVVNSKEMAALLFVHEATRVFHDRLIDFTDKSLFYRLLSRELENCFQIG 2666
            +++ G+L    T +   E    L++HE  RVF+DRLID  D+ +F+ ++     NCF   
Sbjct: 2280 RVIQGVLLCPHTHLQDVEKCIRLWIHEVYRVFYDRLIDKEDRQVFFNMVKETTSNCF--- 2336

Query: 2667 IDGCGKKTCATLACYLTDNKLYRVPISHKCAYIEFKEVFKKVFIHAGLKGKPTVLMVPNL 2726
                 K+T   +  +L+        +      + F + FK     +  K    +  +  L
Sbjct: 2337 -----KQTIEKVLIHLSPTGKI---VDDNIRSLFFGDYFKP---ESDQKIYDEITDLKQL 2385

Query: 2727 NIEQDSFLEDLNYIISSGRIPDLFENVELDSIAMKIRYLTEQSGHM 2772
             +  + +LE+ N  IS   +  +     ++ I+   R L +  GH+
Sbjct: 2386 TVVMEHYLEEFNN-ISKAPMSLVMFRFAIEHISRICRVLKQDKGHL 2430


>gi|223555933 dynein, axonemal, heavy polypeptide 14 isoform 2 [Homo
           sapiens]
          Length = 453

 Score =  904 bits (2337), Expect = 0.0
 Identities = 453/453 (100%), Positives = 453/453 (100%)

Query: 1   METFIPIDLTTENQEMDKEETKTKPRLLRYEEKKYEDVKPLETQPAEIAEKETLEYKTVR 60
           METFIPIDLTTENQEMDKEETKTKPRLLRYEEKKYEDVKPLETQPAEIAEKETLEYKTVR
Sbjct: 1   METFIPIDLTTENQEMDKEETKTKPRLLRYEEKKYEDVKPLETQPAEIAEKETLEYKTVR 60

Query: 61  TFSESLKSEKTEDYLRESIIQQHMVSPEPASLKEKGKSRRKKDQTHACPNVRKARPVSYD 120
           TFSESLKSEKTEDYLRESIIQQHMVSPEPASLKEKGKSRRKKDQTHACPNVRKARPVSYD
Sbjct: 61  TFSESLKSEKTEDYLRESIIQQHMVSPEPASLKEKGKSRRKKDQTHACPNVRKARPVSYD 120

Query: 121 RTEPKDDDVIRNIIRLREKLGWQTILPQHSLKYGSSKIAIQKITLKKPLEDDGEFVYCLP 180
           RTEPKDDDVIRNIIRLREKLGWQTILPQHSLKYGSSKIAIQKITLKKPLEDDGEFVYCLP
Sbjct: 121 RTEPKDDDVIRNIIRLREKLGWQTILPQHSLKYGSSKIAIQKITLKKPLEDDGEFVYCLP 180

Query: 181 RKSPKSLYNPYDLQVVSAHTAKHCKEFWVITASFISKVINIVGSVKEVELIPTLEWLSER 240
           RKSPKSLYNPYDLQVVSAHTAKHCKEFWVITASFISKVINIVGSVKEVELIPTLEWLSER
Sbjct: 181 RKSPKSLYNPYDLQVVSAHTAKHCKEFWVITASFISKVINIVGSVKEVELIPTLEWLSER 240

Query: 241 RHYYLLRQFKIFSDFRMNKAFVTWKLNVKRIKTEKSRSFLYHHLFLADDLFQTCLVYIRG 300
           RHYYLLRQFKIFSDFRMNKAFVTWKLNVKRIKTEKSRSFLYHHLFLADDLFQTCLVYIRG
Sbjct: 241 RHYYLLRQFKIFSDFRMNKAFVTWKLNVKRIKTEKSRSFLYHHLFLADDLFQTCLVYIRG 300

Query: 301 LCEDAINLKNYNDHENNLSAICLVKLDSSRTYSLDEFCEEQLQQATQALKQLEDIRNKAI 360
           LCEDAINLKNYNDHENNLSAICLVKLDSSRTYSLDEFCEEQLQQATQALKQLEDIRNKAI
Sbjct: 301 LCEDAINLKNYNDHENNLSAICLVKLDSSRTYSLDEFCEEQLQQATQALKQLEDIRNKAI 360

Query: 361 SEMKSTFLKVAEKNEIKEYFESKLSEDDTTHFKLPKYRRLLETFFKFVMLVDYIFQELIR 420
           SEMKSTFLKVAEKNEIKEYFESKLSEDDTTHFKLPKYRRLLETFFKFVMLVDYIFQELIR
Sbjct: 361 SEMKSTFLKVAEKNEIKEYFESKLSEDDTTHFKLPKYRRLLETFFKFVMLVDYIFQELIR 420

Query: 421 QLMNTAVTLLLELFNGSAGMPFSVEKKNENLIR 453
           QLMNTAVTLLLELFNGSAGMPFSVEKKNENLIR
Sbjct: 421 QLMNTAVTLLLELFNGSAGMPFSVEKKNENLIR 453


>gi|75677365 dynein heavy chain domain 3 [Homo sapiens]
          Length = 4427

 Score =  893 bits (2307), Expect = 0.0
 Identities = 587/1869 (31%), Positives = 935/1869 (50%), Gaps = 207/1869 (11%)

Query: 2653 RLLSRELENCFQIGIDGCGKKTCATLACYLTDNKLYRVPISHKCAYIEFKEVFKKVFIHA 2712
            R++ +   N   +GI G G+++ A LA  + D   +++ ++      EF++  K+++  A
Sbjct: 2749 RVIGQPRGNMLLVGIGGSGRQSLARLASSICDYTTFQIEVTKHYRKQEFRDDIKRLYRQA 2808

Query: 2713 GLKGKPTVLMVPNLNIEQDSFLEDLNYIISSGRIPDLFENVELDSIAMKIRYLTEQSGHM 2772
            G++ K T  +  +  I  +SFLED+N I+SSG +P+L++  E + I   I          
Sbjct: 2809 GVELKTTSFIFVDTQIADESFLEDINNILSSGEVPNLYKPDEFEEIQSHIIDQARVEQVP 2868

Query: 2773 DNRQSLLSFFQKRIYKNLHIFVIMSPEGPSFRQNCRVYPSMISSCTIDWYERWPEEALLI 2832
            ++  SL ++  +R+  NLHI + +SP G  FR   R YP++++  TI+W+  WP+EALL 
Sbjct: 2869 ESSDSLFAYLIERVQNNLHIVLCLSPMGDPFRNWIRQYPALVNCTTINWFSEWPQEALLE 2928

Query: 2833 VANSFLKEKVNFENRENLKEKLAPTCVQIHKSMKDLNRKYFEETGRFYYTTPNSYLQFME 2892
            VA   L   V+   +EN+  K+A   V +H S+   ++K   E  R  Y TP  YL+ + 
Sbjct: 2929 VAEKCLIG-VDLGTQENIHRKVAQIFVTMHWSVAQYSQKMLLELRRHNYVTPTKYLELLS 2987

Query: 2893 TFAHILRAREEEMQTKRDRFHMGLSTILEATTLVTEMQEELLILGPQVEQKTKETETLME 2952
             +  +L  + +E+  + ++   GL  I E    V  M  EL     +V +  K+ E  + 
Sbjct: 2988 GYKKLLGEKRQELLAQANKLRTGLFKIDETREKVQVMSLELEDAKKKVAEFQKQCEEYLV 3047

Query: 2953 KLRKDSQVVEKVQMLVKQDEEIVAEEVRIVEDYAQKTANELKSVLPAFDKAIVALNALDK 3012
             + +  +  ++ Q  V  + E +A E    +  A     +L+  LPA ++A+ AL +L+K
Sbjct: 3048 IIVQQKREADEQQKAVTANSEKIAVEEIKCQALADNAQKDLEEALPALEEAMRALESLNK 3107

Query: 3013 ADVAELRVYTRPPFLVLTVMNAVCILLQKKPNWATAKLLLSETGFLKKLINLDKDSIPDK 3072
             D+ E++ Y RPP  V  VM AV IL   +P WA AK  L E  F+K LIN DKD+I DK
Sbjct: 3108 KDIGEIKSYGRPPAQVEIVMQAVMILRGNEPTWAEAKRQLGEQNFIKSLINFDKDNISDK 3167

Query: 3073 VFVKLKKIVTLPDFNPHKISLVSVACCSLCQWVIALNNYHEVQKVVGPKQIQVAEAQNVL 3132
            V  K+      PDF P  I  VS+A  SLC WV A+  Y  + +VV PK+I++  A   L
Sbjct: 3168 VLKKIGAYCAQPDFQPDIIGRVSLAAKSLCMWVRAMELYGRLYRVVEPKRIRMNAALAQL 3227

Query: 3133 KIARQRLAEKQRGLQLVEEHLLFLQAAYKDTVAEKQLLANRKTMASRRFQCASVLLTVLE 3192
            +  +  LAE Q  L+ V E L  L+  Y + +A+K+ L  +      + + A +L++ L 
Sbjct: 3228 REKQAALAEAQEKLREVAEKLEMLKKQYDEKLAQKEELRKKSEEMELKLERAGMLVSGLA 3287

Query: 3193 DEKTRWQETINQIDNKLEGILGDILLSAACIVYSGILTPEFRQLIVNK-WETFCIENGIS 3251
             EK RW+ET+  ++  L  ++GD LL+AA + Y G     +R  IVN+ W     E  + 
Sbjct: 3288 GEKARWEETVQGLEEDLGYLVGDCLLAAAFLSYMGPFLTNYRDEIVNQIWIGKIWELQVP 3347

Query: 3252 LSSKFSLIKVMAQKYEISRWHNQGLPHGQYSVENAILIKNGQQWPLLIDPHRQAHKWIRQ 3311
             S  F++   +    ++  W+ QGLP   +S EN I++  G +W L+IDP  QA KWI+ 
Sbjct: 3348 CSPSFAIDNFLCNPTKVRDWNIQGLPSDAFSTENGIIVTRGNRWALMIDPQAQALKWIKN 3407

Query: 3312 MEGSR-LQKLSIEDSNYTKKIENAMKTGGSVLLQNLLETLAPGLKAILKKDIYQKKGHYF 3370
            MEG + L+ + ++ S+Y + +E+A+  G  VLLQN+ E L P L  +L K + +  G   
Sbjct: 3408 MEGGQGLKIIDLQMSDYLRILEHAIHFGYPVLLQNVQEYLDPTLNPMLNKSVARIGGRLL 3467

Query: 3371 IRVGDAEFEYNSNFRLYLSTEIDNPHFLPSVYNFVTMINFTVTFQGLQDQLLSTVVTHEV 3430
            +R+GD E EYN+NFR Y++T++ NPH+ P      T++NF V  QGL+ QLL  VV  E 
Sbjct: 3468 MRIGDKEVEYNTNFRFYITTKLSNPHYSPETSAKTTIVNFAVKEQGLEAQLLGIVVRKER 3527

Query: 3431 PHLEDQRSKLLESISLDAITLEELEEKTLNLLQKALGSILDDDKIVDTLRKSKMTSNEIS 3490
            P LE+Q+  L+ +I+     L+ELE++ L LL +A GS+LDD ++V+TL  SK+T+ E++
Sbjct: 3528 PELEEQKDSLVINIAAGKRKLKELEDEILRLLNEATGSLLDDVQLVNTLHTSKITATEVT 3587

Query: 3491 KRIEATKKAESEIQAIRKNYLPIATRGALLYFLVADLTQINYMYQFSLDWFHQVFVSSVV 3550
            +++E ++  E      R+ Y P A R ++L+F++ D+  I+ MYQFSLD +  +F+ S+ 
Sbjct: 3588 EQLETSETTEINTDLAREAYRPCAQRASILFFVLNDMGCIDPMYQFSLDAYISLFILSI- 3646

Query: 3551 SKSKEQEHSFKREKVSPKEVHEFISISKEPNLENEKNLLDKHIKSAIDMLTKSIFKVVSS 3610
                                          +  +  N L+  I    D  T ++++    
Sbjct: 3647 ------------------------------DKSHRSNKLEDRIDYLNDYHTYAVYRYTCR 3676

Query: 3611 ALFNEDKLCFSFRLCTVIMQNNANGNLIQDDIGFLPEEEWNIFLYSGILINIKSALSQSR 3670
             LF   KL FSF +C  I++ +   N+          +E+N FL  G++++ +  +    
Sbjct: 3677 TLFERHKLLFSFHMCAKILETSGKLNM----------DEYNFFLRGGVVLDREGQM---- 3722

Query: 3671 LTSTFEIGESQHLQWLSDSRWRQCQYVSTHLEPFSLLCKSLLSNVSQWDTFKNSKAVYSL 3730
                    ++    WL+D+ W     +   L  F  L  S       W  +  + A    
Sbjct: 3723 --------DNPCSSWLADAYWDNITELDK-LTNFHGLMNSFEQYPRDWHLWYTNAA---- 3769

Query: 3731 ISTPFSSENASLEENTKPPEETELLNENKETCNPINFPWEKLTSFQRLILVKVLRPESLN 3790
                              PE+  L  E +  CN +          QR+++V+ LR + + 
Sbjct: 3770 ------------------PEKAMLPGEWENACNEM----------QRMLIVRSLRQDRVA 3801

Query: 3791 NSVRKFITEKMGNKYLQRTGVNLKDAYKGSNARTPLILIQTHGIDLTNILLRFAQELKGT 3850
              V  FI   +G+++++   +N+K   + S  R+PL+ I + G+D T+ LL+ A+ + G 
Sbjct: 3802 FCVTSFIITNLGSRFIEPPVLNMKSVLEDSTPRSPLVFILSPGVDPTSALLQLAEHM-GM 3860

Query: 3851 THHVTIISLGRDQAAKAEDLILKALTKTQQWVFLQNCHLATSFMPRLCTIVESFNSPNVT 3910
                  +SLG+ QA  A  L+ + +T+   WVFL NCHL+ S+MP L  +VE     +  
Sbjct: 3861 AQRFHALSLGQGQAPIAARLLREGVTQGH-WVFLANCHLSLSWMPNLDKLVEQLQVEDP- 3918

Query: 3911 IDPEFRLWLSSKSYSSFPIPVLKKGLKIAVESPQGLKSNLLQTFGCTGSGEVTEEIFENP 3970
              P FRLWLSS  +  FPI +L+  +K+  E P+GLK+N+ + +       ++E  F   
Sbjct: 3919 -HPSFRLWLSSIPHPDFPISILQVSIKMTTEPPKGLKANMTRLYQL-----MSEPQFSRC 3972

Query: 3971 DCGQWWKKLLFSLCFFNAVINERKNYGILGWNIAYKFNSSDLGVAIKVLENSLRGQPSIS 4030
                 +KKLLFSLCFF++V+ ERK +  LGWNI Y FN SD  V+  +L   L       
Sbjct: 3973 SKPAKYKKLLFSLCFFHSVLLERKKFLQLGWNIIYGFNDSDFEVSENLLSLYLDEYEETP 4032

Query: 4031 WQALRYLIGEVIYGGRVIDNWDKRCLKTLLYK-FCNPEV--------LKDDFSFSRSASI 4081
            W AL+YLI  + YGG V D+WD+R L T +   FC+  +          + +   +  S+
Sbjct: 4033 WDALKYLIAGINYGGHVTDDWDRRLLTTYINDYFCDQSLSTPFHRLSALETYFIPKDGSL 4092

Query: 4082 KDYIHIIQSLPDDDLPEVLGIHPEAIRSCWETQGEKFIENLIAMQPKTTTANLMIRPEQS 4141
              Y   I  LP  D PE  G HP A  +   T+ +   + L+++QP+ T         Q+
Sbjct: 4093 ASYKEYISLLPGMDPPEAFGQHPNADVASQITEAQTLFDTLLSLQPQITPTR---AGGQT 4149

Query: 4142 KDELVMEILSDLLKRLPLTVEKEEIAVGTPSTLKSMMSSSIWESLSKNLKDHDPLIHCVL 4201
            ++E V+E+ +D+ +++P  ++ E    GT   L                 D  PL + VL
Sbjct: 4150 REEKVLELAADVKQKIPEMIDYE----GTQKLL---------------ALDPSPL-NVVL 4189

Query: 4202 LTFLKQEIKRFDKLLFVIHKSLKDLQLAIKGEIILTQELEEIFNSFLNMRVPTLWQKHAY 4261
            L    QEI+R++ L+  I  SL DL+  I+G I+++  LEEIFN   +  VP LW K AY
Sbjct: 4190 L----QEIQRYNTLMQTILFSLTDLEKGIQGLIVMSTSLEEIFNCIFDAHVPPLWGK-AY 4244

Query: 4262 RSCKPLSSWIDDLIQRLNFFNTWAKVAYTAIQRRYMRFVTVWKQSIPSTSQKCKHPEDSE 4321
             S KPL++W  DL  R+  F  WA  A                                 
Sbjct: 4245 PSQKPLAAWTRDLAMRVEQFELWASRARP------------------------------- 4273

Query: 4322 NNFFEGFPSRYWLPAFFFPQAFLAAVLQDYGRSRGIAVDALTFTHHVISNTTDKDEKFSV 4381
                   P  +WL  F FP  FL AVLQ   R   ++VD+L++   ++S   D +    V
Sbjct: 4274 -------PVIFWLSGFTFPTGFLTAVLQSSARQNNVSVDSLSW-EFIVSTVDDSN---LV 4322

Query: 4382 FMPKKLNIVRRAFKGSASSHTGVYIFGLFIEGARWNREQKILEDSLPLEMCCDFPDIYFL 4441
            + PK                 GV++ GL++EGA W+R+   L ++ P+++ C  P I+F 
Sbjct: 4323 YPPK----------------DGVWVRGLYLEGAGWDRKNSCLVEAEPMQLVCLMPTIHFR 4366

Query: 4442 PTKISTKTPNASNQTDSELYAFECPVYQTPERSRILATTGLPTNFLTSVYL-STKKPPSH 4500
            P         A ++  S    + CP Y  P R    A +    +F+  + L S    P H
Sbjct: 4367 P---------AESRKKSAKGMYSCPCYYYPNR----AGSSDRASFVIGIDLRSGAMTPDH 4413

Query: 4501 WITMRVALL 4509
            WI    ALL
Sbjct: 4414 WIKRGTALL 4422



 Score =  709 bits (1830), Expect = 0.0
 Identities = 453/1381 (32%), Positives = 720/1381 (52%), Gaps = 164/1381 (11%)

Query: 789  HMSHTLIQSVIEKKNK-----------NLLEV---VESSLQQLECDPTEIEEFLEHFIFL 834
            H+  +L+Q   E +NK            LLE+   ++ + +++   P  +EE       +
Sbjct: 1019 HLKFSLVQHCNEWQNKFATLLREMAAGRLLELHTYLKENAEKISRPPQTLEELGVSLQLV 1078

Query: 835  NAISSKISKLEKEFLTMSQLYSVAKHHQIHISEEQI----------AIFQVLLLKFSQLK 884
            +A+   ++ +E +   + + +++ + +++ + +  +           +FQ  LL   Q+ 
Sbjct: 1079 DALKHDLANVETQIPPIHEQFAILEKYEVPVEDSVLEMLDSLNGEWVVFQQTLLDSKQM- 1137

Query: 885  SSMKLSKINKDTAITKFRDNLEACISGLHVDV---GNLKAKIRTPLLLCAGTQVSTAMEM 941
              +K  K    T +    D+ +     L  D    G+  + +     + A  Q++    M
Sbjct: 1138 --LKKHKEKFKTGLIHSADDFKKKAHTLLEDFEFKGHFTSNVG---YMSALDQITQVRAM 1192

Query: 942  IQTLSGEAASLTNKAKAYSHYQDCFSDSQSHMHSVNVEEITQIVLSEISDIEGDLTLRKK 1001
            +  +  E  SL                      ++ + +I Q    ++ ++E +L   ++
Sbjct: 1193 LMAMREEENSLRA--------------------NLGIFKIEQPPSKDLQNLEKELDALQQ 1232

Query: 1002 LWEAQEEWKRASWEWRNSSLQSIDVESVQRNVSKLMHIISVLEKGLPKS--DMVTHLKQV 1059
            +WE   +W+    EW+      +  E+++     L   ++ L K       +++   +  
Sbjct: 1233 IWEIARDWEENWNEWKTGRFLILQTETMETTAHGLFRRLTKLAKEYKDRNWEIIETTRSK 1292

Query: 1060 VTEFKQELPIIIALGNPCLKPRHWEALQEIIGKSVPLD-KNCKVENLLALKMFQYENEIN 1118
            + +FK+ +P+I  L NP L+ RHW+ +++ I +    + ++  +E ++ L M Q+  +I 
Sbjct: 1293 IEQFKRTMPLISDLRNPALRERHWDQVRDEIQREFDQESESFTLEQIVELGMDQHVEKIG 1352

Query: 1119 DMSTSATNEAALEKMLFKIIDFWNTTPLPLILHHTEIYSIFIIPSIDDISAQLEESQVIL 1178
            ++S SAT E A+E  L  I   W+ T L ++ +  + +    +   +++   LE++QV L
Sbjct: 1353 EISASATKELAIEVALQNIAKTWDVTQLDIVPYKDKGHHR--LRGTEEVFQALEDNQVAL 1410

Query: 1179 ATIKGSPHIGPIKDLVNEWDQNLTLFSYTLEEWMNCQRNWLYLEPVFHSSEIRRQLPAET 1238
            +T+K S  +   +  V+ W++ L+L    +E  +  QR W+YLE +F   +IR+QLP E+
Sbjct: 1411 STMKASRFVKAFEKDVDHWERCLSLILEVIEMILTVQRQWMYLENIFLGEDIRKQLPNES 1470

Query: 1239 ELFSQVISMWKKIMSKIQNKQNALQITTSAGVLEILQNCNIHLEHIKKSLEDYLEVKRLI 1298
             LF QV S WK IM ++    NAL+ T   G+L+ L   N  LE I+KSL+ YLE KR I
Sbjct: 1471 TLFDQVNSNWKAIMDRMNKDNNALRSTHHPGLLDTLIEMNTILEDIQKSLDMYLETKRHI 1530

Query: 1299 FPRFYFLSNAELLDILADSRNPESVQPHLVKCFENIKQLLIWKQDIGPPAVKM----LIS 1354
            FPRFYFLSN +LL+IL  SRNPE+VQPHL KCF+NIK L I  Q +G P+ K     + S
Sbjct: 1531 FPRFYFLSNDDLLEILGQSRNPEAVQPHLKKCFDNIKLLRI--QKVGGPSSKWEAVGMFS 1588

Query: 1355 AEGEGLVLPKKIRVRSAVEQWLVNVEKSMFDVL----------------KKERYIYNI-- 1396
             +GE +     + +   VE WL +VE++M   L                K+++++     
Sbjct: 1589 GDGEYIDFLHSVFLEGPVESWLGDVEQTMRVTLRDLLRNCHLALRKFLNKRDKWVKEWAG 1648

Query: 1397 -ILLFQSQIMFYNDCVKSFVSSYSR--EKLEKVHAGLMCHLEEVADLVVLDTSNSRTKAI 1453
             +++  SQI +  D  K  +++  R  +K+ KV       +       +        +  
Sbjct: 1649 QVVITASQIQWTADVTKCLLTAKERADKKILKVMKKNQVSILNKYSEAIRGNLTKIMRLK 1708

Query: 1454 LGALLILYVHCRDIVINLLLKNIFNAEDFEWTRHLQYKWNEKQKLCYVSQGNASFTYGYE 1513
            + AL+ + +H RD++  L    + +   F+W   L++ W +    C + Q N  F Y YE
Sbjct: 1709 IVALVTIEIHARDVLEKLYKSGLMDVNSFDWLSQLRFYWEKDLDDCVIRQTNTQFQYNYE 1768

Query: 1514 YLGCTSRLVITPLTDRCWLTLMEALHLNLGGCPAGPAGTGKTETVKDLAKSLGKHCVVFN 1573
            YLG + RLVITPLTDRC++TL  ALHL+ GG P GPAGTGKTETVKDL K+LG + +V N
Sbjct: 1769 YLGNSGRLVITPLTDRCYMTLTTALHLHRGGSPKGPAGTGKTETVKDLGKALGIYVIVVN 1828

Query: 1574 CFEDLDYKIVRKFFFGLVQSGAWSCFDEFNLIDLEVLSVIASQILTIKAAKDNYSARFVL 1633
            C E LDYK + + + GL Q+GAW CFDEFN I++EVLSV+A QIL I +A       F  
Sbjct: 1829 CSEGLDYKSMGRMYSGLAQTGAWGCFDEFNRINIEVLSVVAHQILCILSALAAGLTHFHF 1888

Query: 1634 EGKEIRINMSCAVFITMNPRYGGGVELPDNLKSLFRPVAMMVPHYQMIAEIILFSFGFKS 1693
            +G EI +  SC +FITMNP Y G  ELP+NLKS+FRP+AM+VP   +IAEIILF  GF +
Sbjct: 1889 DGFEINLVWSCGIFITMNPGYAGRTELPENLKSMFRPIAMVVPDSTLIAEIILFGEGFGN 1948

Query: 1694 ANSLSGKLTNLYELARKQLSQQDHYNFGLRSLKIVLIMAGTKKREFKCLSEADETLIVIE 1753
               L+ K+  LY LA +QLS+QDHY+FGLR+L  +L  AG K+R    L++ +  L+   
Sbjct: 1949 CKILAKKVYTLYSLAVQQLSRQDHYDFGLRALTSLLRYAGKKRRLQPDLTDEEVLLL--- 2005

Query: 1754 AIREASLPKCPPEDVPLFENIIGDIFPEVTVLKVNQLALEKVIYTATQQLGLQNWSSQKE 1813
            ++R+ ++ K    D PLF  I+ D+FP + +  ++   L + +    + +GLQ+      
Sbjct: 2006 SMRDMNIAKLTSVDAPLFNAIVQDLFPNIELPVIDYGKLRETVEQEIRDMGLQSTPFTLT 2065

Query: 1814 KIIQFYNQLQVCVGVMLVGPTGGGKTTVRRILEKALTLLPIA---DFLSVAERKSASKIS 1870
            K+ Q Y         M+VG TG GKT   RIL+ +L+ L  A   +F  V E        
Sbjct: 2066 KVFQLYETKNSRHSTMIVGCTGSGKTASWRILQASLSSLCRAGDPNFNIVREFP------ 2119

Query: 1871 ERKGKVDICVLNPKCVTLSELYGQLDPNTMEWTDGLLSATIRSYVYFNTPKNTKKDIDLR 1930
                      LNPK ++L ELYG+ D +T EWTDG+                        
Sbjct: 2120 ----------LNPKALSLGELYGEYDLSTNEWTDGI------------------------ 2145

Query: 1931 LKSRISDLSNVFKLDSSDTTETDDNIFEEIEKVVKIPENHNFDWQWIILDGPVDTFWVEN 1990
                   LS+V +   +D                        D +WI+ DGPVDT W+EN
Sbjct: 2146 -------LSSVMRTACADEKP---------------------DEKWILFDGPVDTLWIEN 2177

Query: 1991 LNSVLDDTRTLCLANSERIALTNKIRVIFEVDNLSQASPATVSRCAMVYMDPVDLGWEPY 2050
            +NSV+DD + L L N ERIA+  ++ ++FEV++L+ ASPATVSRC MVY D  DLGW+PY
Sbjct: 2178 MNSVMDDNKVLTLINGERIAMPEQVSLLFEVEDLAMASPATVSRCGMVYTDYADLGWKPY 2237

Query: 2051 VKSWLLKTSKIISQSGVDCLEFMIKNSVTDGLQFIRNRQKFQPYPMEDITVVITLCRILD 2110
            V+SWL K  K    + V+ L+ M +  +   L F ++  K +  P+ + + + +LC++  
Sbjct: 2238 VQSWLEKRPK----AEVEPLQRMFEKLINKMLAFKKDNCK-ELVPLPEYSGITSLCKLYS 2292

Query: 2111 A 2111
            A
Sbjct: 2293 A 2293



 Score =  156 bits (394), Expect = 5e-37
 Identities = 99/324 (30%), Positives = 164/324 (50%), Gaps = 18/324 (5%)

Query: 2369 DTLLYSEIKKSSSLKQNITILIPETHKTATGSSDNPTKKPEVRTNKKLLKNNDHKGVVVS 2428
            DT+ Y+ +  S    QN  +L+             P    +    + +L++       V 
Sbjct: 2394 DTVRYNYLVSSLVANQNPILLV------------GPVGTGKTSIAQSVLQSLPSSQWSVL 2441

Query: 2429 TINFSTNVTAAKTKEMILKKLIRRTKDTLGAPKNNRILIFIDDMNMPVSDMYGAQPPLEL 2488
             +N S   T+   + +I  ++ +RTK          ++ F+DD+NMP  DM+G+QPPLEL
Sbjct: 2442 VVNMSAQTTSNNVQSIIESRVEKRTKGVYVPFGGKSMITFMDDLNMPAKDMFGSQPPLEL 2501

Query: 2489 IRQLLDLGGVYDTEKNTWKNIQDLSIVAACVPVVND---ISPRLLKHFSMLVLPHPSQDI 2545
            IR  +D G  YD  K T K I+++ ++AA  P       ISPRL   F+++ +  P++  
Sbjct: 2502 IRLWIDYGFWYDRTKQTIKYIREMFLMAAMGPPGGGRTVISPRLRSRFNIINMTFPTKSQ 2561

Query: 2546 LCTIFQAHLGIYFSINNFTPEVQKSKDQIISCSLAIYHQVRQNMLPTPTKCHYMFNLRDM 2605
            +  IF   +     + +F  EV+   + +   +L +Y+ V Q  LPTPTK HY+FNLRD+
Sbjct: 2562 IIRIFGTMINQ--KLQDFEEEVKPIGNVVTEATLDMYNTVVQRFLPTPTKMHYLFNLRDI 2619

Query: 2606 FKLLLGLLQADRTVVNSKEMAALLFVHEATRVFHDRLIDFTDKSLFYRLLSRELENCFQI 2665
             K+  G+L+A++   ++K     L++HE  RVF DRL+D  D   F  ++S +L + F +
Sbjct: 2620 SKVFQGMLRANKDFHDTKSSITRLWIHECFRVFSDRLVDAADTEAFMGIISDKLGSFFDL 2679

Query: 2666 GIDG-CGKKTCATLACYLTDNKLY 2688
                 C  K       +L + K+Y
Sbjct: 2680 TFHHLCPSKRPPIFGDFLKEPKVY 2703


>gi|19115954 dynein, axonemal, heavy chain 5 [Homo sapiens]
          Length = 4624

 Score =  776 bits (2003), Expect = 0.0
 Identities = 513/1902 (26%), Positives = 912/1902 (47%), Gaps = 239/1902 (12%)

Query: 2642 LIDFTDKSLFYRLLSRELE----NCFQIGIDGCGKKTCATLACYLTDNKLYRVPISHKCA 2697
            ++ F D  +    +SR +     N   +G+ G GK++   LA ++     +++ ++    
Sbjct: 2928 MVFFADAMVHLVKISRVIRTPQGNALLVGVGGSGKQSLTRLASFIAGYVSFQITLTRSYN 2987

Query: 2698 YIEFKEVFKKVFIHAGLKGKPTVLMVPNLNIEQDSFLEDLNYIISSGRIPDLFENVELDS 2757
                 E  K ++  AG +GK    +  +  I+ +SFLE +N ++SSG + +LF   E+D 
Sbjct: 2988 TSNLMEDLKVLYRTAGQQGKGITFIFTDNEIKDESFLEYMNNVLSSGEVSNLFARDEIDE 3047

Query: 2758 IAMKIRYLTEQSGH--MDNRQSLLSFFQKRIYKNLHIFVIMSPEGPSFRQNCRVYPSMIS 2815
            I   +  + ++     +   ++L  +F  R+ +NLHI +  SP G  FR     +P++IS
Sbjct: 3048 INSDLASVMKKEFPRCLPTNENLHDYFMSRVRQNLHIVLCFSPVGEKFRNRALKFPALIS 3107

Query: 2816 SCTIDWYERWPEEALLIVANSFLKEKVNFENRENLKEKLAPTCVQIHKSMKDLNRKYFEE 2875
             CTIDW+ RWP++AL+ V+  FL    + +    +K+++          + +    YF+ 
Sbjct: 3108 GCTIDWFSRWPKDALVAVSEHFLTS-YDIDCSLEIKKEVVQCMGSFQDGVAEKCVDYFQR 3166

Query: 2876 TGRFYYTTPNSYLQFMETFAHILRAREEEMQTKRDRFHMGLSTILEATTLVTEMQEELLI 2935
              R  + TP SYL F++ +  I   +  E++T  +R + GL  + EA+  V  + +EL  
Sbjct: 3167 FRRSTHVTPKSYLSFIQGYKFIYGEKHVEVRTLANRMNTGLEKLKEASESVAALSKELEA 3226

Query: 2936 LGPQVEQKTKETETLMEKLRKDSQVVEKVQMLVKQDEEIVAEEVRIVEDYAQKTANELKS 2995
               +++    + + +++++   +Q  EKV+  V++ ++     V  +         +L++
Sbjct: 3227 KEKELQVANDKADMVLKEVTMKAQAAEKVKAEVQKVKDRAQAIVDSISKDKAIAEEKLEA 3286

Query: 2996 VLPAFDKAIVALNALDKADVAELRVYTRPPFLVLTVMNAVCILLQKK------------- 3042
              PA ++A  AL  +  +D+A +R   RPP L++ +M+ V +L Q+K             
Sbjct: 3287 AKPALEEAEAALQTIRPSDIATVRTLGRPPHLIMRIMDCVLLLFQRKVSAVKIDLEKSCT 3346

Query: 3043 -PNWATAKLLLSETGFLKKLINLDKDSIPDKVFVKLKKIVTLPDFNPHKISLVSVACCSL 3101
             P+W  +  L++   FL+ L    KD+I ++V   L     +PD+N      V      L
Sbjct: 3347 MPSWQESLKLMTAGNFLQNLQQFPKDTINEEVIEFLSPYFEMPDYNIETAKRVCGNVAGL 3406

Query: 3102 CQWVIALNNYHEVQKVVGPKQIQVAEAQNVLKIARQRLAEKQRGLQLVEEHLLFLQAAYK 3161
            C W  A+ ++  + K V P +  +   +N   +A Q L + Q  L   +  L  +QA Y+
Sbjct: 3407 CSWTKAMASFFSINKEVLPLKANLVVQENRHLLAMQDLQKAQAELDDKQAELDVVQAEYE 3466

Query: 3162 DTVAEKQLLANRKTMASRRFQCASVLLTVLEDEKTRWQETINQIDNKLEGILGDILLSAA 3221
              + EKQ L         + Q AS L++ L  EK RW E   +   + + ++GD+LL+ A
Sbjct: 3467 QAMTEKQTLLEDAERCRHKMQTASTLISGLAGEKERWTEQSQEFAAQTKRLVGDVLLATA 3526

Query: 3222 CIVYSGILTPEFRQLIVNKWETFCIENGISLSSKFSLIKVMAQKYEISRWHNQGLPHGQY 3281
             + YSG    EFR L++N W        I      +L +++     IS W+ QGLP+   
Sbjct: 3527 FLSYSGPFNQEFRDLLLNDWRKEMKARKIPFGKNLNLSEMLIDAPTISEWNLQGLPNDDL 3586

Query: 3282 SVENAILIKNGQQWPLLIDPHRQAHKWIRQMEG-SRLQKLSIEDSNYTKKIENAMKTGGS 3340
            S++N I++    ++PLLIDP  Q   WI+  E  + LQ  S+    +   +E+++  G  
Sbjct: 3587 SIQNGIIVTKASRYPLLIDPQTQGKIWIKNKESRNELQITSLNHKYFRNHLEDSLSLGRP 3646

Query: 3341 VLLQNLLETLAPGLKAILKKDIYQKKGHYFIRVGDAEFEYNSNFRLYLSTEIDNPHFLPS 3400
            +L++++ E L P L  +L+++  +    + ++VGD E +    FRLY++T++ NP + P 
Sbjct: 3647 LLIEDVGEELDPALDNVLERNFIKTGSTFKVKVGDKEVDVLDGFRLYITTKLPNPAYTPE 3706

Query: 3401 VYNFVTMINFTVTFQGLQDQLLSTVVTHEVPHLEDQRSKLLESISLDAITLEELEEKTLN 3460
            +    ++I+FTVT +GL+DQLL  V+  E   LE +R+ L+E ++ +   ++ELE+  L 
Sbjct: 3707 ISARTSIIDFTVTMKGLEDQLLGRVILTEKQELEKERTHLMEDVTANKRRMKELEDNLLY 3766

Query: 3461 LLQKALGSILDDDKIVDTLRKSKMTSNEISKRIEATKKAESEIQAIRKNYLPIATRGALL 3520
             L    GS+++D+ ++  L  +K T+ E+++++E + + E +I + R+ Y P+ATRG++L
Sbjct: 3767 RLTSTQGSLVEDESLIVVLSNTKRTAEEVTQKLEISAETEVQINSAREEYRPVATRGSIL 3826

Query: 3521 YFLVADLTQINYMYQFSLDWFHQVFVSSVVSKSKEQEHSFKREKVSPKEVHEFISISKEP 3580
            YFL+ ++  +N MYQ SL  F  +F           + S  R   SP             
Sbjct: 3827 YFLITEMRLVNEMYQTSLRQFLGLF-----------DLSLARSVKSP------------- 3862

Query: 3581 NLENEKNLLDKHIKSAIDMLTKSIFKVVSSALFNEDKLCFSFRLCTVI-MQNNANGNLIQ 3639
                   +  K I + I+ +T  ++K  +  L+ E K  F+  L   I +Q N       
Sbjct: 3863 -------ITSKRIANIIEHMTYEVYKYAARGLYEEHKFLFTLLLTLKIDIQRNR------ 3909

Query: 3640 DDIGFLPEEEWNIFLYSGILINIKSALSQSRLTSTFEIGESQHLQWLSDSRWRQCQYVST 3699
                 +  EE+   +  G  +++K+                +  +W+ D  W     +S 
Sbjct: 3910 -----VKHEEFLTLIKGGASLDLKAC-------------PPKPSKWILDITWLNLVELS- 3950

Query: 3700 HLEPFSLLCKSLLSNVSQWDTFKNSKAVYSLISTPFSSENASLEENTKPPEETELLNENK 3759
             L  FS +   +  N   W  +             F  EN         PEE  L N   
Sbjct: 3951 KLRQFSDVLDQISRNEKMWKIW-------------FDKEN---------PEEEPLPNAYD 3988

Query: 3760 ETCNPINFPWEKLTSFQRLILVKVLRPESLNNSVRKFITEKMGNKYLQRTGVNLKDAYKG 3819
            ++          L  F+RL+L++   P+      RK+I + MG KY +   ++L+  ++ 
Sbjct: 3989 KS----------LDCFRRLLLIRSWCPDRTIAQARKYIVDSMGEKYAEGVILDLEKTWEE 4038

Query: 3820 SNARTPLILIQTHGIDLTNILLRFAQELKGTTHHVTIISLGRDQAAKAEDLILKALTKTQ 3879
            S+ RTPLI + + G D T+ ++   + LK  T +V   S+G+ Q   A  L+ + +    
Sbjct: 4039 SDPRTPLICLLSMGSDPTDSIIALGKRLKIETRYV---SMGQGQEVHARKLLQQTMA-NG 4094

Query: 3880 QWVFLQNCHLATSFMPRLCTIVESFNSPNVTIDPEFRLWLSSKSYSSFPIPVLKKGLKIA 3939
             W  LQNCHL   FM  L  I+         +   FRLW++++++  FPI +L+  +K A
Sbjct: 4095 GWALLQNCHLGLDFMDELMDII----IETELVHDAFRLWMTTEAHKQFPITLLQMSIKFA 4150

Query: 3940 VESPQGLKSNLLQTFGCTGSGEVTEEIFENPDCGQWWKKLLFSLCFFNAVINERKNYGIL 3999
             + PQGL++ L +T+    SG V++++ +    G  WK +L+++ F ++ + ER+ +G L
Sbjct: 4151 NDPPQGLRAGLKRTY----SG-VSQDLLD-VSSGSQWKPMLYAVAFLHSTVQERRKFGAL 4204

Query: 4000 GWNIAYKFNSSDLGVAIKVLENSLRG---QPSISWQALRYLIGEVIYGGRVIDNWDKRCL 4056
            GWNI Y+FN +D    ++ ++N L     +  +SW  +RY+IGE+ YGGRV D++DKR L
Sbjct: 4205 GWNIPYEFNQADFNATVQFIQNHLDDMDVKKGVSWTTIRYMIGEIQYGGRVTDDYDKRLL 4264

Query: 4057 KTLLYKFCNPEVLKDDFSF------SRSASIKDYIHIIQSLPDDDLPEVLGIHPEAIRSC 4110
             T    + +  +   DFSF       + +++ +Y+  IQSLP  D PEV G+HP A  + 
Sbjct: 4265 NTFAKVWFSENMFGPDFSFYQGYNIPKCSTVDNYLQYIQSLPAYDSPEVFGLHPNADITY 4324

Query: 4111 WETQGEKFIENLIAMQPKTTTANLMIRPEQSKDELVMEILSDLLKRLPLTVEKEEIAVGT 4170
                 +  ++ ++ +QPK T+       +++++ +V  +  D+L++LP            
Sbjct: 4325 QSKLAKDVLDTILGIQPKDTSGG----GDETREAVVARLADDMLEKLP------------ 4368

Query: 4171 PSTLKSMMSSSIWESLSKNLKDHDPLIHCVLLTFLKQEIKRFDKLLFVIHKSLKDLQLAI 4230
                   +   + E L K +    P     +  FL+QEI R  ++L ++  +L +L+LAI
Sbjct: 4369 ----PDYVPFEVKERLQK-MGPFQP-----MNIFLRQEIDRMQRVLSLVRSTLTELKLAI 4418

Query: 4231 KGEIILTQELEEIFNSFLNMRVPTLWQKHAYRSCKPLSSWIDDLIQRLNFFNTWAKVAYT 4290
             G II+++ L +  +   + R+P  W+K ++ S   L  W  +LI+R + F +W      
Sbjct: 4419 DGTIIMSENLRDALDCMFDARIPAWWKKASWIS-STLGFWFTELIERNSQFTSWV----- 4472

Query: 4291 AIQRRYMRFVTVWKQSIPSTSQKCKHPEDSENNFFEGFPSRYWLPAFFFPQAFLAAVLQD 4350
                                              F G P  +W+  FF PQ FL A+ Q+
Sbjct: 4473 ----------------------------------FNGRPHCFWMTGFFNPQGFLTAMRQE 4498

Query: 4351 YGR-SRGIAVDALTFTHHVISNTTDKDEKFSVFMPKKLNIVRRAFKGSASSHTGVYIFGL 4409
              R ++G A+D +     V+ N   K  K  +               SA    GVY++GL
Sbjct: 4499 ITRANKGWALDNM-----VLCNEVTKWMKDDI---------------SAPPTEGVYVYGL 4538

Query: 4410 FIEGARWNREQKILEDSLPLEMCCDFPDIYFLPTKISTKTPNASNQTDSELYAFECPVYQ 4469
            ++EGA W++    L +S P  +    P I             A N T  +   + CP+Y+
Sbjct: 4539 YLEGAGWDKRNMKLIESKPKVLFELMPVIRIY----------AENNTLRDPRFYSCPIYK 4588

Query: 4470 TPERSRILATTGLPTNFLTSVYLSTKKPPSHWITMRVALLCE 4511
             P R+ +        N++ +V L T + P HW+   VALLC+
Sbjct: 4589 KPVRTDL--------NYIAAVDLRTAQTPEHWVLRGVALLCD 4622



 Score =  548 bits (1411), Expect = e-155
 Identities = 355/1120 (31%), Positives = 566/1120 (50%), Gaps = 109/1120 (9%)

Query: 988  EISDIEGDLTLRKKLWEAQEEWKRASWEWRNSSLQSIDVESVQRNVSKLMHIISVLEKGL 1047
            ++ +I+  L L +K++            + +     +++E +   + +  +    L + L
Sbjct: 1401 QLLEIKKQLNLLQKIYTLYNSVIETVNSYYDILWSEVNIEKINNELLEFQNRCRKLPRAL 1460

Query: 1048 PKSDMVTHLKQVVTEFKQELPIIIALGNPCLKPRHWEALQEIIGKSVPL-DKNCKVENLL 1106
                    LK+++ +F +  P++  + +  +  RHWE +  + G S+ + +++ K+ N++
Sbjct: 1461 KDWQAFLDLKKIIDDFSECCPLLEYMASKAMMERHWERITTLTGHSLDVGNESFKLRNIM 1520

Query: 1107 ALKMFQYENEINDMSTSATNEAALEKMLFKIIDFWNTTPLPLILHHTEIYSIFIIPSIDD 1166
               + +Y+ EI D+  SA  E  +E+ L ++I+ W+          T    +    S  +
Sbjct: 1521 EAPLLKYKEEIEDICISAVKERDIEQKLKQVINEWDNKTFTFGSFKTRGELLLRGDSTSE 1580

Query: 1167 ISAQLEESQVILATIKGSPHIGPIKDLVNEWDQNLTLFSYTLEEWMNCQRNWLYLEPVFH 1226
            I A +E+S ++L ++  + +  P K  + +W Q L+  +  +E WM  Q  W+YLE VF 
Sbjct: 1581 IIANMEDSLMLLGSLLSNRYNMPFKAQIQKWVQYLSNSTDIIESWMTVQNLWIYLEAVFV 1640

Query: 1227 SSEIRRQLPAETELFSQVISMWKKIMSKIQNKQNALQITTSAGVL-EILQNCNIHLEHIK 1285
              +I +QLP E + FS +   W KIM++     + +Q       L ++L +    LE  +
Sbjct: 1641 GGDIAKQLPKEAKRFSNIDKSWVKIMTRAHEVPSVVQCCVGDETLGQLLPHLLDQLEICQ 1700

Query: 1286 KSLEDYLEVKRLIFPRFYFLSNAELLDILADSRNPESVQPHLVKCFENIKQLLIWKQDIG 1345
            KSL  YLE KRL FPRF+F+S+  LL+IL  + +  ++Q HL+  F+NIK +   ++   
Sbjct: 1701 KSLTGYLEKKRLCFPRFFFVSDPALLEILGQASDSHTIQAHLLNVFDNIKSVKFHEKIYD 1760

Query: 1346 PPAVKMLISAEGEGLVLPKKIRVRSAVEQWL-------------------VNVEKSMFDV 1386
               +  + S EGE + L K +     VE WL                    N++++ F +
Sbjct: 1761 --RILSISSQEGETIELDKPVMAEGNVEVWLNSLLEESQSSLHLVIRQAAANIQETGFQL 1818

Query: 1387 LKKERYIYNIILLFQSQIMFYNDCVKSFVSS-YSREKLEKVHAGLMCHLEEVADLVVLDT 1445
             +        + L   Q+++  D  ++  ++ + ++ ++K +   +  L  + D+   D 
Sbjct: 1819 TEFLSSFPAQVGLLGIQMIWTRDSEEALRNAKFDKKIMQKTNQAFLELLNTLIDVTTRDL 1878

Query: 1446 SNSRTKAILGALLILYVHCRDIVINLLLKNIFNAEDFEWTRHLQYKWNEKQKLCYVSQGN 1505
            S++  +     L+ ++VH RDI  +L   +I +  DFEW +  ++ +NE      +   +
Sbjct: 1879 SSTE-RVKYETLITIHVHQRDIFDDLCHMHIKSPMDFEWLKQCRFYFNEDSDKMMIHITD 1937

Query: 1506 ASFTYGYEYLGCTSRLVITPLTDRCWLTLMEALHLNLGGCPAGPAGTGKTETVKDLAKSL 1565
             +F Y  E+LGCT RLVITPLTDRC++TL +AL +++GG PAGPAGTGKTET KD+ + L
Sbjct: 1938 VAFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMSMGGAPAGPAGTGKTETTKDMGRCL 1997

Query: 1566 GKHCVVFNCFEDLDYKIVRKFFFGLVQSGAWSCFDEFNLIDLEVLSVIASQILTIKAAKD 1625
            GK+ VVFNC + +D++ + + F GL QSG+W CFDEFN IDL VLSV A QI  I   K 
Sbjct: 1998 GKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIDLPVLSVAAQQISIILTCKK 2057

Query: 1626 NYSARFVL-EGKEIRINMSCAVFITMNPRYGGGVELPDNLKSLFRPVAMMVPHYQMIAEI 1684
             +   F+  +G  + +N    +F+TMNP Y G  ELP+NLK  FR VAMMVP  Q+I  +
Sbjct: 2058 EHKKSFIFTDGDNVTMNPEFGLFLTMNPGYAGRQELPENLKINFRSVAMMVPDRQIIIRV 2117

Query: 1685 ILFSFGFKSANSLSGKLTNLYELARKQLSQQDHYNFGLRSLKIVLIMAGTKKREFKCLSE 1744
             L S GF     L+ K   LY+L  +QLS+Q HY+FGLR++  VL   G  KR       
Sbjct: 2118 KLASCGFIDNVVLARKFFTLYKLCEEQLSKQVHYDFGLRNILSVLRTLGAAKR---ANPM 2174

Query: 1745 ADETLIVIEAIREASLPKCPPEDVPLFENIIGDIFPEVTVLKVNQLALEKVIYTATQQLG 1804
              E+ IV+  +R+ +L K   ED PLF ++I D+FP + + K     LE  I    ++ G
Sbjct: 2175 DTESTIVMRVLRDMNLSKLIDEDEPLFLSLIEDLFPNILLDKAGYPELEAAISRQVEEAG 2234

Query: 1805 LQNWSSQKEKIIQFYNQLQVCVGVMLVGPTGGGKTTVRRILEKALTLLPIADFLSVAERK 1864
            L N    K K+IQ +   +V  G+M +GP+G GKTT    L +A+T              
Sbjct: 2235 LINHPPWKLKVIQLFETQRVRHGMMTLGPSGAGKTTCIHTLMRAMT-------------D 2281

Query: 1865 SASKISERKGKVDICVLNPKCVTLSELYGQLDPNTMEWTDGLLSATIRSYVYFNTPKNTK 1924
                  E +       +NPK +T  +++G+LD  T +WTDG+ S   R            
Sbjct: 2282 CGKPHREMR-------MNPKAITAPQMFGRLDVATNDWTDGIFSTLWRK----------- 2323

Query: 1925 KDIDLRLKSRISDLSNVFKLDSSDTTETDDNIFEEIEKVVKIPENHNFDWQWIILDGPVD 1984
                LR K                         E I  ++  P     D  WI       
Sbjct: 2324 ---TLRAKKG-----------------------EHIWIILDGP----VDAIWI------- 2346

Query: 1985 TFWVENLNSVLDDTRTLCLANSERIALTNKIRVIFEVDNLSQASPATVSRCAMVYMDPVD 2044
                ENLNSVLDD +TL LAN +RI +    ++IFE  N+  ASPATVSR  MV+M    
Sbjct: 2347 ----ENLNSVLDDNKTLTLANGDRIPMAPNCKIIFEPHNIDNASPATVSRNGMVFMSSSI 2402

Query: 2045 LGWEPYVKSWLLKTS--------KIISQSGVDCLEFMIKN 2076
            L W P ++ +L K S        ++ ++S  D   F I+N
Sbjct: 2403 LDWSPILEGFLKKRSPQEAEILRQLYTESFPDLYRFCIQN 2442



 Score =  120 bits (302), Expect = 2e-26
 Identities = 77/255 (30%), Positives = 130/255 (50%), Gaps = 5/255 (1%)

Query: 2414 KKLLKNNDHKGVVVSTINFSTNVTAAKTKEMILKKLIRRTKDTLGAPKNNRILIFIDDMN 2473
            K  +   D +  ++ ++NFS+  T    +  I   + +R   T G P   ++ +FIDD+N
Sbjct: 2601 KGFMSKYDPECHMIKSLNFSSATTPLMFQRTIESYVDKRMGTTYGPPAGKKMTVFIDDVN 2660

Query: 2474 MPVSDMYGAQPPLELIRQLLDLGGVYDTEK-NTWKNIQDLSIVAACVPVV---NDISPRL 2529
            MP+ + +G Q   E++RQL++  G Y+ EK   + +I D+  +AA +      NDI  RL
Sbjct: 2661 MPIINEWGDQVTNEIVRQLMEQNGFYNLEKPGEFTSIVDIQFLAAMIHPGGGRNDIPQRL 2720

Query: 2530 LKHFSMLVLPHPSQDILCTIFQA-HLGIYFSINNFTPEVQKSKDQIISCSLAIYHQVRQN 2588
             + FS+     PS+  +  IF    +G Y +   F+ EV+ S  +++  +  ++   +  
Sbjct: 2721 KRQFSIFNCTLPSEASVDKIFGVIGVGHYCTQRGFSEEVRDSVTKLVPLTRRLWQMTKIK 2780

Query: 2589 MLPTPTKCHYMFNLRDMFKLLLGLLQADRTVVNSKEMAALLFVHEATRVFHDRLIDFTDK 2648
            MLPTP K HY+FNLRD+ ++  G+L     V+        L+ HE  RV  DR    +D 
Sbjct: 2781 MLPTPAKFHYVFNLRDLSRVWQGMLNTTSEVIKEPNDLLKLWKHECKRVIADRFTVSSDV 2840

Query: 2649 SLFYRLLSRELENCF 2663
            + F + L   +E  F
Sbjct: 2841 TWFDKALVSLVEEEF 2855


>gi|198442844 dynein, axonemal, heavy chain 10 [Homo sapiens]
          Length = 4471

 Score =  764 bits (1974), Expect = 0.0
 Identities = 526/1885 (27%), Positives = 934/1885 (49%), Gaps = 235/1885 (12%)

Query: 2652 YRLLSRELENCFQIGIDGCGKKTCATLACYLTDNKLYRVPISHKCAYIEFKEVFKKVFIH 2711
            +R++  +  +   +G+ G GK++ + LA +    +++ + +S   +   F+E  K +++ 
Sbjct: 2789 HRIIRMDRGHALLVGVGGSGKQSLSRLAAFTASCEVFEILLSRGYSENSFREDLKSLYLK 2848

Query: 2712 AGLKGKPTVLMVPNLNIEQDSFLEDLNYIISSGRIPDLFENVELDSIAMKIRYLTEQSGH 2771
             G++ K  + +  + ++ ++ FLE +N +++SG +P LF   E +SI  +I     + G 
Sbjct: 2849 LGIENKAMIFLFTDAHVAEEGFLELINNMLTSGIVPALFSEEEKESILSQIGQEALKQGM 2908

Query: 2772 MDNRQSLLSFFQKRIYKNLHIFVIMSPEGPSFRQNCRVYPSMISSCTIDWYERWPEEALL 2831
               ++S+  +F  +   NLHI + MSP G + R  CR +P M+++  IDW+  WP +AL 
Sbjct: 2909 GPAKESVWQYFVNKSANNLHIVLGMSPVGDTLRTWCRNFPGMVNNTGIDWFMPWPPQALH 2968

Query: 2832 IVANSFL--KEKVNFENRENLKEKLAPTCVQIHKSMKDLNRKYFEETGRFYYTTPNSYLQ 2889
             VA SFL     +  EN EN+ + +    V +H+S+   ++++ ++  R  Y TP +YL 
Sbjct: 2969 AVAKSFLGYNPMIPAENIENVVKHV----VLVHQSVDHYSQQFLQKLRRSNYVTPKNYLD 3024

Query: 2890 FMETFAHILRAREEEMQTKRDRFHMGLSTILEATTLVTEMQEELLILGPQVEQKTKETET 2949
            F+ T++ +L  + +    +  R   GL  + EAT  + E+ ++L      + +K+   E 
Sbjct: 3025 FINTYSKLLDEKTQCNIAQCKRLDGGLDKLKEATIQLDELNQKLAEQKIVLAEKSAACEA 3084

Query: 2950 LMEKLRKDSQVVEKVQMLVKQDEEIVAEEVRIVEDYAQKTANELKSVLPAFDKAIVALNA 3009
            L+E++  ++ V E+ + L ++    + E+ +++     +    L  V+P  + A + L  
Sbjct: 3085 LLEEIAVNTAVAEEKKKLAEEKAMEIEEQNKVIAMEKAEAETTLAEVMPILEAAKLELQK 3144

Query: 3010 LDKADVAELRVYTRPPFLVLTVMNAVCILL-QKKPNWATAKLLLSETGFLKKLINLDKDS 3068
            LDK+DV E+R + +PP  V TV   + I+   K+ NW TAK ++S+  FL+ L+ +D DS
Sbjct: 3145 LDKSDVTEIRSFAKPPKQVQTVCECILIMKGYKELNWKTAKGVMSDPNFLRSLMEIDFDS 3204

Query: 3069 IPDKVFVKLKKIVTLPDFNPHKISLVSVACCSLCQWVIALNNYHEVQKVVGPKQIQVAEA 3128
            I       +K ++   +    ++  VS A   + ++V A+  Y +V + + PK+ +VA  
Sbjct: 3205 ITQSQVKNIKGLLKTLNTTTEEMEAVSKAGLGMLKFVEAVMGYCDVFREIKPKREKVARL 3264

Query: 3129 QNVLKIARQRLAEKQRGLQLVEEHLLFLQAAYKDTVAEKQLLANRKTMASRRFQCASVLL 3188
            +    + ++ L   Q  L  +++ L  L A Y+  + EKQ L     +  RR   A  L+
Sbjct: 3265 ERNFYLTKRELERIQNELAAIQKELETLGAKYEAAILEKQKLQEEAEIMERRLIAADKLI 3324

Query: 3189 TVLEDEKTRWQETINQIDNKLEGILGDILLSAACIVYSGILTPEFRQLIVNK-WETFCIE 3247
            + L  E  RW   ++++ ++   +LGD LL AA + Y G  T EFR  +VN+ W+   +E
Sbjct: 3325 SGLGSENIRWLNDLDELMHRRVKLLGDCLLCAAFLSYEGAFTWEFRDEMVNRIWQNDILE 3384

Query: 3248 NGISLSSKFSLIKVMAQKYEISRWHNQGLPHGQYSVENAILIKNGQQWPLLIDPHRQAHK 3307
              I LS  F L  ++    EISRW +QGLP  + SV+N IL     ++PL IDP +QA  
Sbjct: 3385 REIPLSQPFRLESLLTDDVEISRWGSQGLPPDELSVQNGILTTRASRFPLCIDPQQQALN 3444

Query: 3308 WI-RQMEGSRLQKLSIEDSNYTKKIENAMKTGGSVLLQNLLETLAPGLKAILKKDIYQKK 3366
            WI R+ E + L+  S  D ++ K++E ++K G   L +++ E + P +  +L+K+I   +
Sbjct: 3445 WIKRKEEKNNLRVASFNDPDFLKQLEMSIKYGTPFLFRDVDEYIDPVIDNVLEKNIKVSQ 3504

Query: 3367 GHYFIRVGDAEFEYNSNFRLYLSTEIDNPHFLPSVYNFVTMINFTVTFQGLQDQLLSTVV 3426
            G  FI +GD E +Y+SNFRLYL+T++ NP + PSV+    +IN+TVT +GL+DQLLS +V
Sbjct: 3505 GRQFIILGDKEVDYDSNFRLYLNTKLANPRYSPSVFGKAMVINYTVTLKGLEDQLLSVLV 3564

Query: 3427 THEVPHLEDQRSKLLESISLDAITLEELEEKTLNLLQKALGSILDDDKIVDTLRKSKMTS 3486
             +E   LE+QR  L++  S +   L++LE+  L  L  + G++LD+  +V TL ++K  +
Sbjct: 3565 AYERRELEEQREHLIQETSENKNLLKDLEDSLLRELATSTGNMLDNVDLVHTLEETKSKA 3624

Query: 3487 NEISKRIEATKKAESEIQAIRKNYLPIATRGALLYFLVADLTQINYMYQFSLDWFHQVFV 3546
             E+S++++  +K   +I  +R  Y P A RGA+L+F+++++  +N MYQ+SL  F +VF 
Sbjct: 3625 TEVSEKLKLAEKTALDIDRLRDGYRPAARRGAILFFVLSEMALVNSMYQYSLIAFLEVFR 3684

Query: 3547 SSVVSKSKEQEHSFKREKVSPKEVHEFISISKEPNLENEKNLLDKHIKSAIDMLTKSIFK 3606
             S+             +K  P                   ++L K +++ +D LT SI+ 
Sbjct: 3685 LSL-------------KKSLP------------------DSILMKRLRNIMDTLTFSIYN 3713

Query: 3607 VVSSALFNEDKLCFSFRLCTVIMQNNANGNLIQDDIGFLPEEEWNIFLYSGILINIKSAL 3666
               + LF   KL FSF +   I Q            G +P+EE + FL   I      +L
Sbjct: 3714 HGCTGLFERHKLLFSFNMTIKIEQAE----------GRVPQEELDFFLKGNI------SL 3757

Query: 3667 SQSRLTSTFEIGESQHLQWLSDSRWRQCQYVSTHLEPFSLLCKSLLSNVSQW-DTFKNSK 3725
             +S+          +   WLSD  W          E   LL +    N  Q  D  +N++
Sbjct: 3758 EKSK--------RKKPCAWLSDQGW----------EDIILLSEMFSDNFGQLPDDVENNQ 3799

Query: 3726 AVYSLISTPFSSENASLEENTKPPEETELLNENKETCNPINFPWEKLTSFQRLILVKVLR 3785
             V+                     +E   L+  ++   P+ +    +T FQ+L++++  R
Sbjct: 3800 TVW---------------------QEWYDLDSLEQFPVPLGYD-NNITPFQKLLILRCFR 3837

Query: 3786 PESLNNSVRKFITEKMGNKYLQRTGVNLKDAYKGSNARTPLILIQTHGIDLTNILLRFAQ 3845
             + +  +V  ++T  MG KY+Q   ++ +  ++ S   +P++ I + G D    L++ A+
Sbjct: 3838 VDRVYRAVTDYVTVTMGEKYVQPPMISFEAIFEQSTPHSPIVFILSPGSDPATDLMKLAE 3897

Query: 3846 ELKGTTHHVTIISLGRDQAAKAEDLILKALTKTQQWVFLQNCHLATSFMPRLCTIVESFN 3905
                  + +  +++G+ Q   A  L+  A+ +  QW+ LQNCHL   ++  L   +E   
Sbjct: 3898 RSGFGGNRLKFLAMGQGQEKVALQLLETAVAR-GQWLMLQNCHLLVKWLKDLEKSLERIT 3956

Query: 3906 SPNVTIDPEFRLWLSSKSYSSFPIPVLKKGLKIAVESPQGLKSNLLQTFGCTGSGEVTEE 3965
             P+    P+FRLWL++     FPI +L+K LK+  E P GLK N+  T+      +++ E
Sbjct: 3957 KPH----PDFRLWLTTDPTKGFPIGILQKSLKVVTEPPNGLKLNMRATY-----FKISHE 4007

Query: 3966 IFENPDCGQ-WWKKLLFSLCFFNAVINERKNYGILGWNIAYKFNSSDLGVAIKVLENSL- 4023
            + +   C    +K L++ L FF+AV+ ER+ +G +GWN+ Y FN SD  V +++L   L 
Sbjct: 4008 MLD--QCPHPAFKPLVYVLAFFHAVVQERRKFGKIGWNVYYDFNESDFQVCMEILNTYLT 4065

Query: 4024 ----RGQPSISWQALRYLIGEVIYGGRVIDNWDKRCLKTLLYKFCNPEVLK--DDFSFSR 4077
                +  P I W +L+YLIGEV+YGGR ID++D+R L   + ++    +      F F R
Sbjct: 4066 KAFQQRDPRIPWGSLKYLIGEVMYGGRAIDSFDRRILTIYMDEYLGDFIFDTFQPFHFFR 4125

Query: 4078 SASI----------KDYIHIIQSLPDDDLPEVLGIHPEAIRSCWETQGEKFIENLIAMQP 4127
            +  +          + ++  I++LP  + PEV G+HP A    +         +L+ +QP
Sbjct: 4126 NKEVDYKIPVGDEKEKFVEAIEALPLANTPEVFGLHPNAEIGYYTQAARDMWAHLLELQP 4185

Query: 4128 KTTTANLMIRPEQSKDELVMEILSDLLKRLPLTVEKEEI--AVGTPSTLKSMMSSSIWES 4185
            +T  ++  I    S+D+ + ++  ++  ++P   + +++   +GT  +  S++       
Sbjct: 4186 QTGESSSGI----SRDDYIGQVAKEIENKMPKVFDLDQVRKRLGTGLSPTSVV------- 4234

Query: 4186 LSKNLKDHDPLIHCVLLTFLKQEIKRFDKLLFVIHKSLKDLQLAIKGEIILTQELEEIFN 4245
                               L QE++RF+KL+  + KSL +LQ A+ GE+ ++ EL+++  
Sbjct: 4235 -------------------LLQELERFNKLVVRMTKSLAELQRALAGEVGMSNELDDVAR 4275

Query: 4246 SFLNMRVPTLWQKHAYRSCKPLSSWIDDLIQRLNFFNTWAKVAYTAIQRRYMRFVTVWKQ 4305
            S     +P +W++ A  + K L +W+   ++R +               +YM +VT    
Sbjct: 4276 SLFIGHIPNIWRRLAPDTLKSLGNWMVYFLRRFS---------------QYMLWVT---- 4316

Query: 4306 SIPSTSQKCKHPEDSENNFFEGFPSRYWLPAFFFPQAFLAAVLQDYGRSRGIAVDALT-F 4364
                                E  PS  WL     P+++L A++Q   R  G  +D  T F
Sbjct: 4317 --------------------ESEPSVMWLSGLHIPESYLTALVQATCRKNGWPLDRSTLF 4356

Query: 4365 THHVISNTTDKDEKFSVFMPKKLNIVRRAFKGSASSHTGVYIFGLFIEGARWNREQKILE 4424
            T   ++   D DE           +  RA +       G ++ GL++EGA W+ E+  L 
Sbjct: 4357 TQ--VTKFQDADE-----------VNERAGQ-------GCFVSGLYLEGADWDIEKGCLI 4396

Query: 4425 DSLPLEMCCDFPDIYFLPTKI-STKTPNASNQTDSELYAFECPVYQTPERSRILATTGLP 4483
             S P  +  D P +  +P +    K  N           F  PVY T  R   +      
Sbjct: 4397 KSKPKVLVVDLPILKIIPIEAHRLKLQN----------TFRTPVYTTSMRRNAMG----- 4441

Query: 4484 TNFLTSVYLSTKKPPSHWITMRVAL 4508
               +    L T +  SHW+   V L
Sbjct: 4442 VGLVFEADLFTTRHISHWVLQGVCL 4466



 Score =  681 bits (1757), Expect = 0.0
 Identities = 454/1411 (32%), Positives = 703/1411 (49%), Gaps = 197/1411 (13%)

Query: 970  QSHMHSVNVEEITQIVLS---EISDIEGDLTLRKKLWEAQEEWKRASWEWRNSSLQSIDV 1026
            +S     N E++  + ++   E+  ++ +++  + ++E  E  K A  EW  +   +++V
Sbjct: 1232 KSRQELANAEKLFDLPITMYPELLKVQKEMSGLRMIYELYEGLKVAKEEWSQTLWINLNV 1291

Query: 1027 ESVQRNVSKLMHIISVLEKGLPKSDMVTHLKQVVTEFKQELPIIIALGNPCLKPRHWEAL 1086
            + +Q  +   +  +  L + +    +  +L+  +  FK  +P+++ L N  L+ RHW+ L
Sbjct: 1292 QILQEGIEGFLRALRKLPRPVRGLSVTYYLEAKMKAFKDSIPLLLDLKNEALRDRHWKEL 1351

Query: 1087 QEIIGKSVPLDKNCKVENLLALKMFQYENEINDMSTSATNEAALEKMLFKIIDFWNTTPL 1146
             E       + +   +EN+ A+++ ++ + +N++ T+A  E A+EK + +I+D W     
Sbjct: 1352 MEKTSVFFEMTETFTLENMFAMELHKHTDVLNEIVTAAIKEVAIEKAVKEILDTWENMKF 1411

Query: 1147 PLILHHTEIYSI-FIIPSIDDISAQLEESQVILATIKGSPHIGPIKDLVNEWDQNLTLFS 1205
             ++ +        +I+ S+D+I   L+++   L +I GS  +GP    V++W++ L+L  
Sbjct: 1412 TVVKYCKGTQERGYILGSVDEIIQSLDDNTFNLQSISGSRFVGPFLQTVHKWEKTLSLIG 1471

Query: 1206 YTLEEWMNCQRNWLYLEPVFHSSEIRRQLPAETELFSQVISMWKKIMSKIQNKQNALQIT 1265
              +E WM  QR W+YLE +F   +IR QLP E + F  +  ++K+IM +        +  
Sbjct: 1472 EVIEIWMLVQRKWMYLESIFIGGDIRSQLPEEAKKFDNIDKVFKRIMGETLKDPVIKRCC 1531

Query: 1266 TSAGVLEILQNCNIHLEHIKKSLEDYLEVKRLIFPRFYFLSNAELLDILADSRNPESVQP 1325
             +   L  LQN +  LE  +KSL DYL+ KR  FPRF+F+S+ ELL IL  S +P  VQ 
Sbjct: 1532 EAPNRLSDLQNVSEGLEKCQKSLNDYLDSKRNAFPRFFFISDDELLSILGSS-DPLCVQE 1590

Query: 1326 HLVKCFENIKQLLIWKQDIGPPAVKMLISAEGEGLVLPKKIRVRSAVEQWLVNVEKSMFD 1385
            H++K ++NI  L     D G   V  +ISAEGE +   K +R    VE W+  V   M  
Sbjct: 1591 HMIKMYDNIASLRFNDGDSGEKLVSAMISAEGEVMEFRKILRAEGRVEDWMTAVLNEMRR 1650

Query: 1386 ----VLKKERYIY--------------NIILLFQSQIMFYNDCVKSFVSSYSREKLEKVH 1427
                + K+  + Y               +++L  SQ+ +  +    F  +   EK    +
Sbjct: 1651 TNRLITKEAIFRYCEDRSRVDWMLLYQGMVVLAASQVWWTWEVEDVFHKAQKGEKQAMKN 1710

Query: 1428 AGLMCH--LEEVADLVVLDTSNSRTKAILGALLILYVHCRDIVINLLLKNIFNAEDFEWT 1485
             G   H  ++E+   + +  S +  K     +LI+ VH RDIV + +  +I  A +F+W 
Sbjct: 1711 YGRKMHRQIDELVTRITMPLSKNDRKKY-NTVLIIDVHARDIVDSFIRGSILEAREFDWE 1769

Query: 1486 RHLQYKWNEKQKLCYVSQGNASFTYGYEYLGCTSRLVITPLTDRCWLTLMEALHLNLGGC 1545
              L++ W+ +     + Q   +F YGYEY+G   RLVITPLTDR +LTL +AL + LGG 
Sbjct: 1770 SQLRFYWDREPDELNIRQCTGTFGYGYEYMGLNGRLVITPLTDRIYLTLTQALSMYLGGA 1829

Query: 1546 PAGPAGTGKTETVKDLAKSLGKHCVVFNCFEDLDYKIVRKFFFGLVQSGAWSCFDEFNLI 1605
            PAGPAGTGKTET KDLAK+LG  CVV NC E +DY+ V K F GL Q GAW CFDEFN I
Sbjct: 1830 PAGPAGTGKTETTKDLAKALGLLCVVTNCGEGMDYRAVGKIFSGLAQCGAWGCFDEFNRI 1889

Query: 1606 DLEVLSVIASQILTIKAAKDNYSARFVLEGKEIRINMSCAVFITMNPRYGGGVELPDNLK 1665
            D  VLSVI+SQI TI+ A  +    F  EG+EI ++    +FITMNP Y G  ELP+++K
Sbjct: 1890 DASVLSVISSQIQTIRNALIHQLTTFQFEGQEISLDSRMGIFITMNPGYAGRTELPESVK 1949

Query: 1666 SLFRPVAMMVPHYQMIAEIILFSFGFKSANSLSGKLTNLYELARKQLSQQDHYNFGLRSL 1725
            +LFRPV ++VP  Q I EI+LFS GF  A +L+ K+T LY+LAR+QLS+Q HY+FGLR+L
Sbjct: 1950 ALFRPVVVIVPDLQQICEIMLFSEGFLEAKTLAKKMTVLYKLAREQLSKQYHYDFGLRAL 2009

Query: 1726 KIVLIMAGTKKREFKCLSEADETLIVIEAIREASLPKCPPEDVPLFENIIGDIFPEVTVL 1785
            K VL+MAG  KR     S+  E ++++ A+R+ +LPK   EDVPLF  +I D+FP +   
Sbjct: 2010 KSVLVMAGELKRGS---SDLREDVVLMRALRDMNLPKFVFEDVPLFLGLISDLFPGLDCP 2066

Query: 1786 KVNQLALEKVIYTATQQLGLQNWSSQKEKIIQFYNQLQVCVGVMLVGPTGGGKTTVRRIL 1845
            +V        +    ++ G      Q +K++Q +  +      M+VGPT GGK+ V   L
Sbjct: 2067 RVRYPDFNDAVEQVLEENGYAVLPIQVDKVVQMFETMLTRHTTMVVGPTRGGKSVVINTL 2126

Query: 1846 EKALTLLPIADFLSVAERKSASKISERKGKVDICVLNPKCVTLSELYGQLDPNTMEWTDG 1905
             +A T L +                       + +LNPK V++ ELYG LDP T +WTDG
Sbjct: 2127 CQAQTKLGLT--------------------TKLYILNPKAVSVIELYGILDPTTRDWTDG 2166

Query: 1906 LLSATIRSYVYFNTPKNTKKDIDLRLKSRISDLSNVFKLDSSDTTETDDNIFEEIEKVVK 1965
            +LS                                              NIF EI K   
Sbjct: 2167 VLS----------------------------------------------NIFREINKPTD 2180

Query: 1966 IPENHNFDWQWIILDGPVDTFWVENLNSVLDDTRTLCLANSERIALTNKIRVIFEVDNLS 2025
              E      ++I+ DG VD  WVEN+NSV+DD R L LAN ERI L     ++FEV +L 
Sbjct: 2181 KKER-----KYILFDGDVDALWVENMNSVMDDNRLLTLANGERIRLQAHCALLFEVGDLQ 2235

Query: 2026 QASPATVSRCAMVYMDPVDLGWEPYVKSWLLKTSKIISQSGVDCLEFMIKNSVTDGLQFI 2085
             ASPATVSRC MVY+DP +L + PY K W+ +    + Q  ++ L               
Sbjct: 2236 YASPATVSRCGMVYVDPKNLKYRPYWKKWVNQIPNKVEQYNLNSLF-------------- 2281

Query: 2086 RNRQKFQPYPMEDITVVITLCRILDAFFDFMGKNGGFEQSDDLNDTSSKEANSQRESVTF 2145
               +K+ PY M+ I   I   R  +     + +        DLN  +  +     +++  
Sbjct: 2282 ---EKYVPYLMDVIVEGIVDGRQAEKLKTIVPQT-------DLNMVT--QLAKMLDALLE 2329

Query: 2146 KDIEKRDENTWYPEKNPDKLTKIIQKLFVFAFTWAFGGALNREDEHRENIPFCPSLEPDS 2205
             +IE  D               +++  F+ A   + G +L  +   +             
Sbjct: 2330 GEIEDLD---------------LLECYFLEALYCSLGASLLEDGRMK------------- 2361

Query: 2206 LAKVTYDFDKLVHELFGNSS---QVGWKHWGQSQGRRRKGNCINLPTGECSIFGYFVDIE 2262
                   FD+ +  L   S+   +  W + G+  G+        LPT    ++ +  D +
Sbjct: 2362 -------FDEYIKRLASLSTVDTEGVWANPGELPGQ--------LPT----LYDFHFDNK 2402

Query: 2263 QCEFIPWSDLVPNDQTLIQRGTSLLTNLQRSGGNFLKITECGECINYTATRDTTCLSFLM 2322
            + +++PWS LVP      +R              F+ I           T DTT  ++++
Sbjct: 2403 RNQWVPWSKLVPEYIHAPER-------------KFINIL--------VHTVDTTRTTWIL 2441

Query: 2323 SLLLKNSCPVLLTGESGVGKTAAINQMLEKL 2353
              ++K   PV+  GESG  KTA     L+ L
Sbjct: 2442 EQMVKIKQPVIFVGESGTSKTATTQNFLKNL 2472



 Score =  153 bits (386), Expect = 4e-36
 Identities = 93/273 (34%), Positives = 148/273 (54%), Gaps = 13/273 (4%)

Query: 2382 LKQNITILIPETHKTATGSSDNPTKKPEVRTNKKLLKNNDHKGVVVSTINFSTNVTAAKT 2441
            L+Q + I  P      +G+S       +  T +  LKN   +  +V  +NFS+  T+   
Sbjct: 2441 LEQMVKIKQPVIFVGESGTS-------KTATTQNFLKNLSEETNIVLMVNFSSRTTSMDI 2493

Query: 2442 KEMILKKLIRRTKDTLGAPKNNRILIFIDDMNMPVSDMYGAQPPLELIRQLLDLGGVYDT 2501
            +  +   + +RTKDT G P   R+L+F+DDMNMP  D YG Q P+ L++ LL+ G +YD 
Sbjct: 2494 QRNLEANVEKRTKDTYGPPMGKRLLVFMDDMNMPRVDEYGTQQPIALLKLLLEKGYLYDR 2553

Query: 2502 EKN-TWKNIQDLSIVAACVPV---VNDISPRLLKHFSMLVLPHPSQDILCTIFQAHLGIY 2557
             K    K+I+DL  +AA        N++ PR +  FS+  +P PS++ L  I+ + L  +
Sbjct: 2554 GKELNCKSIRDLGFIAAMGKAGGGRNEVDPRFISLFSVFNVPFPSEESLHLIYSSILKGH 2613

Query: 2558 FSINNFTPEVQKSKDQIISCSLAIYHQVRQNMLPTPTKCHYMFNLRDMFKLLLGLLQADR 2617
             S   F   +     ++  C+LA+Y  + Q++ PTP+K HY+FNLRD+ ++  GL+  + 
Sbjct: 2614 TS--TFHESIVAVSGKLTFCTLALYKNIVQDLPPTPSKFHYIFNLRDLSRVFNGLVLTNP 2671

Query: 2618 TVVNSKEMAALLFVHEATRVFHDRLIDFTDKSL 2650
                +      ++ +E  RVFHDRLI  TDK L
Sbjct: 2672 ERFQTVAQMVRVWRNECLRVFHDRLISETDKQL 2704


>gi|126012497 dynein, axonemal, heavy polypeptide 8 [Homo sapiens]
          Length = 4490

 Score =  760 bits (1963), Expect = 0.0
 Identities = 506/1888 (26%), Positives = 896/1888 (47%), Gaps = 235/1888 (12%)

Query: 2653 RLLSRELENCFQIGIDGCGKKTCATLACYLTDNKLYRVPISHKCAYIEFKEVFKKVFIHA 2712
            R++     N   +G+ G GK++ + LA ++   +++++ ++         +  K ++  A
Sbjct: 2807 RIIRTSCGNALLVGVGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVA 2866

Query: 2713 GLKGKPTVLMVPNLNIEQDSFLEDLNYIISSGRIPDLFENVELDSIAMKIRYLTEQS--G 2770
            G  GK    +  +  I+ ++FLE LN ++SSG I +LF   E+D I   +  + ++    
Sbjct: 2867 GADGKGITFIFTDSEIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPR 2926

Query: 2771 HMDNRQSLLSFFQKRIYKNLHIFVIMSPEGPSFRQNCRVYPSMISSCTIDWYERWPEEAL 2830
            H     +L  +F  R  KNLH+ +  SP G  FR     +P +IS CT+DW+ RWP EAL
Sbjct: 2927 HPPTFDNLYEYFISRSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREAL 2986

Query: 2831 LIVANSFLKEKVNFENRENLKEKLAPTCVQIHKSMKDLNRKYFEETGRFYYTTPNSYLQF 2890
            + VA+ FL +  N      +K ++  T    H  + +    YF+   R  + TP SYL F
Sbjct: 2987 IAVASYFLSD-YNIVCSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSF 3045

Query: 2891 METFAHILRAREEEMQTKRDRFHMGLSTILEATTLVTEMQEELLILGPQVEQKTKETETL 2950
            +  + +I   + + +  + +R ++GL  ++EA+  V ++ ++L +   ++   + + + +
Sbjct: 3046 INGYKNIYAEKVKFINEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEV 3105

Query: 2951 MEKLRKDSQVVEKVQMLVKQDEEIVAEEVRIVEDYAQKTANELKSVLPAFDKAIVALNAL 3010
            + ++   +Q   K++  V++ ++   + V  ++    K  ++L++  PA ++A  ALN +
Sbjct: 3106 LAEVTVSAQASAKIKNEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTI 3165

Query: 3011 DKADVAELRVYTRPPFLVLTVMNAVCILLQKK--------------PNWATAKLLLSETG 3056
               D+A +R   +PP L++ +M+ V +L QKK              P+W  +  L+S TG
Sbjct: 3166 KPNDIATVRKLAKPPHLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATG 3225

Query: 3057 FLKKLINLDKDSIPDKVFVKLKKIVTLPDFNPHKISLVSVACCSLCQWVIALNNYHEVQK 3116
            FL  L    KD+I ++    L+    + D+       V      L  W +A+  ++ + +
Sbjct: 3226 FLWSLQQFPKDTINEETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINR 3285

Query: 3117 VVGPKQIQVAEAQNVLKIARQRLAEKQRGLQLVEEHLLFLQAAYKDTVAEKQLLANRKTM 3176
             V P +  +A+ +  L +A   L + Q  L   +  L  +QA +   + EK  L N    
Sbjct: 3286 EVLPLKANLAKQEGRLAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADT 3345

Query: 3177 ASRRFQCASVLLTVLEDEKTRWQETINQIDNKLEGILGDILLSAACIVYSGILTPEFRQ- 3235
              ++ Q AS L+  L  EK RW +   +   ++  ++GDILL    + Y G     FR  
Sbjct: 3346 CRKKMQAASTLIDGLSGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNY 3405

Query: 3236 LIVNKWETFCIENGISLSSKFSLIKVMAQKYEISRWHNQGLPHGQYSVENAILIKNGQQW 3295
            L+ ++WE       I  +   +LI ++     I  W  QGLP    S++N I++    ++
Sbjct: 3406 LLKDQWEMELRARKIPFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRY 3465

Query: 3296 PLLIDPHRQAHKWIRQMEGSR-LQKLSIEDSNYTKKIENAMKTGGSVLLQNLLETLAPGL 3354
            PLLIDP  Q   WI+  E    LQ  S+    +   +E+++  G  +L++++ E L P L
Sbjct: 3466 PLLIDPQTQGKTWIKSKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPAL 3525

Query: 3355 KAILKKDIYQKKGHYFIRVGDAEFEYNSNFRLYLSTEIDNPHFLPSVYNFVTMINFTVTF 3414
              +L+K+  +    + ++VGD E +    F+LY++T++ NP F P +    ++I+FTVT 
Sbjct: 3526 DNVLEKNFIKSGTTFKVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTM 3585

Query: 3415 QGLQDQLLSTVVTHEVPHLEDQRSKLLESISLDAITLEELEEKTLNLLQKALGSILDDDK 3474
            +GL++QLL  V+  E   LE +R KLLE ++ +   ++ELE+  L  L    GS++DD+ 
Sbjct: 3586 KGLENQLLRRVILTEKQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDES 3645

Query: 3475 IVDTLRKSKMTSNEISKRIEATKKAESEIQAIRKNYLPIATRGALLYFLVADLTQINYMY 3534
            ++  LR +K T+ E+S+++    + E +I A ++ + P ATRG++LYFL+ +++ +N MY
Sbjct: 3646 LIGVLRTTKQTAAEVSEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMY 3705

Query: 3535 QFSLDWFHQVFVSSVVSKSKEQEHSFKREKVSPKEVHEFISISKEPNLENEKNLLDKHIK 3594
            Q SL  F ++F           + S  R + SP                    L  K I 
Sbjct: 3706 QTSLAQFLKLF-----------DQSMARSEKSP--------------------LPQKRIT 3734

Query: 3595 SAIDMLTKSIFKVVSSALFNEDKLCFSFRLCTVIMQNNANGNLIQDDIGFLPEEEWNIFL 3654
            + I+ LT  +F      L+   K  F   +   I              G +   E+   +
Sbjct: 3735 NIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQR----------GTVKHREFQALI 3784

Query: 3655 YSGILINIKSALSQSRLTSTFEIGESQHLQWLSDSRWRQCQYVSTHLEPFSLLCKSLLSN 3714
              G  +++K+                +  +W+ D  W     +S  L  F+ +   +  N
Sbjct: 3785 KGGAALDLKAC-------------PPKPYRWILDMTWLNLVELSK-LPQFAEIMNQISRN 3830

Query: 3715 VSQWDTFKNSKAVYSLISTPFSSENASLEENTKPPEETELLNENKETCNPINFPWEKLTS 3774
               W ++ +  A                EE   P    +  N++ +TC+           
Sbjct: 3831 EKGWKSWFDKDAP---------------EEEIIP----DGYNDSLDTCH----------- 3860

Query: 3775 FQRLILVKVLRPESLNNSVRKFITEKMGNKYLQRTGVNLKDAYKGSNARTPLILIQTHGI 3834
              +L+L++   P+      RK+I + +  KY +   +NL+  ++ S+ RTPLI   + G 
Sbjct: 3861 --KLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKTWEESDTRTPLICFLSMGS 3918

Query: 3835 DLTNILLRFAQELKGTTHHVTIISLGRDQAAKAEDLILKALTKTQQWVFLQNCHLATSFM 3894
            D TN +   A++LK        IS+G+ Q   A  LI  ++ +   WV LQNCHL   FM
Sbjct: 3919 DPTNQIDALAKKLK---LECRTISMGQGQEVHARKLIQMSMQQGG-WVLLQNCHLGLEFM 3974

Query: 3895 PRLC-TIVESFNSPNVTIDPEFRLWLSSKSYSSFPIPVLKKGLKIAVESPQGLKSNLLQT 3953
              L  T++ +  S     D  FR+W++++ +  FPI +L+  LK   E PQG+++ L +T
Sbjct: 3975 EELLETLITTEAS-----DDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQGVRAGLKRT 4029

Query: 3954 FGCTGSGEVTEEIFENPDCGQWWKKLLFSLCFFNAVINERKNYGILGWNIAYKFNSSDLG 4013
            F   G  +   +I   P     WK +L+++ F ++ + ER+ +G LGWNI Y+FNS+D  
Sbjct: 4030 FA--GINQDLLDISNLP----MWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSADFS 4083

Query: 4014 VAIKVLENSLRG---QPSISWQALRYLIGEVIYGGRVIDNWDKRCLKTLLYKFCNPEVLK 4070
             +++ ++N L     +  +SW  +RY+IGEV YGGRV D++DKR L      + + ++ +
Sbjct: 4084 ASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEKMFE 4143

Query: 4071 DDFSFSRS------ASIKDYIHIIQSLPDDDLPEVLGIHPEAIRSCWETQGEKFIENLIA 4124
              F F          ++  Y   IQSLP  D PEV G+HP A  +         +E +  
Sbjct: 4144 PSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLETITN 4203

Query: 4125 MQPKTTTANLMIRPEQSKDELVMEILSDLLKRLPLTVEKEEIAVGTPSTLKSMMSSSIWE 4184
            +QPK +   +     ++++ +V  +  D+L +LP            P  +   + S + +
Sbjct: 4204 IQPKESGGGV----GETREAIVYRLSEDMLSKLP------------PDYIPHEVKSRLIK 4247

Query: 4185 SLSKNLKDHDPLIHCVLLTFLKQEIKRFDKLLFVIHKSLKDLQLAIKGEIILTQELEEIF 4244
                N  +           FL+QEI R  +++ ++  SL DL+LAI+G II+++ L +  
Sbjct: 4248 MGHLNSMN----------IFLRQEIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDAL 4297

Query: 4245 NSFLNMRVPTLWQKHAYRSCKPLSSWIDDLIQRLNFFNTWAKVAYTAIQRRYMRFVTVWK 4304
            ++  + R+P LW++ ++ S   L  W  +L++R   F+TW                    
Sbjct: 4298 DNMYDARIPQLWKRVSWDS-STLGFWFTELLERNAQFSTW-------------------- 4336

Query: 4305 QSIPSTSQKCKHPEDSENNFFEGFPSRYWLPAFFFPQAFLAAVLQDYGRS-RGIAVDALT 4363
                                FEG P+ +W+  FF PQ FL A+ Q+  R+ +G A+D +T
Sbjct: 4337 -------------------IFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVT 4377

Query: 4364 FTHHVISNTTDKDEKFSVFMPKKLNIVRRAFKGSASSHTGVYIFGLFIEGARWNREQKIL 4423
              + V+  T ++                     ++    GVYI+GL+++GA W+R    L
Sbjct: 4378 IHNEVLRQTKEEI--------------------TSPPGEGVYIYGLYMDGAAWDRRNGKL 4417

Query: 4424 EDSLPLEMCCDFPDIYFLPTKISTKTPNASNQTDSELYAFECPVYQTPERSRILATTGLP 4483
             +S P  +    P ++           N++   D +LY   CP+Y+ P R+ +       
Sbjct: 4418 MESTPKVLFTQLPVLHIFAI-------NSTAPKDPKLYV--CPIYKKPRRTDL------- 4461

Query: 4484 TNFLTSVYLSTKKPPSHWITMRVALLCE 4511
              F+T VYL T   P HWI   VALLC+
Sbjct: 4462 -TFITVVYLRTVLSPDHWILRGVALLCD 4488



 Score =  578 bits (1491), Expect = e-164
 Identities = 381/1284 (29%), Positives = 621/1284 (48%), Gaps = 120/1284 (9%)

Query: 800  EKKNKNLLEVVESSLQQLECDPTEIEEFLEHFIFLNAISSKISKLEKEFLTMSQLYSVAK 859
            +KK   ++  +   L++L     ++++       L+ I     +++     + + Y++  
Sbjct: 1092 KKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTLGPIEEAYAILN 1151

Query: 860  HHQIHISEEQIAIFQVLLLKFSQLKSSMKLSKINKDTAITKFRDNLEACISGLHVDVGNL 919
              ++ +++E+      L   F++L+S     + +      KF+ NL   +     DV N 
Sbjct: 1152 RFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLESVEVFREDVINF 1211

Query: 920  KAKIRTPLLLCAGTQVSTAMEMIQTLSGEAASLTNKAKAYSHYQDCFSDSQSHMHSVNVE 979
                     +        A   +Q        L  K   YS  +  F             
Sbjct: 1212 AEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFG------------ 1259

Query: 980  EITQIVLSEISDIEGDLTLRKKLWEAQEEWKRASWEWRNSSLQSIDVESVQRNVSKLMHI 1039
             +       +     +L L +KL+   +    +   +       +D+E +   + +  + 
Sbjct: 1260 -LPVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNR 1318

Query: 1040 ISVLEKGLPKSDMVTHLKQVVTEFKQELPIIIALGNPCLKPRHWEALQEIIGK--SVPLD 1097
               L KGL        LK+ + +F +  P++  + N  +K RHW+ + E+ G    V  D
Sbjct: 1319 CRKLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESD 1378

Query: 1098 KNCKVENLLALKMFQYENEINDMSTSATNEAALEKMLFKIIDFWNTTPLPLILHHTEIYS 1157
              C + N++   + +++++I D+  SA  E  +E  L ++I+ W    L       +   
Sbjct: 1379 SFC-LRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGEL 1437

Query: 1158 IFIIPSIDDISAQLEESQVILATIKGSPHIGPIKDLVNEWDQNLTLFSYTLEEWMNCQRN 1217
            +       +I   +E+S ++L ++  + +  P K  +  W   L+  S  +EEW+  Q  
Sbjct: 1438 LLKGTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNL 1497

Query: 1218 WLYLEPVFHSSEIRRQLPAETELFSQVISMWKKIMSKIQNKQNALQITTSAGVL-EILQN 1276
            W+YLE VF   +I +QLP E + F  +   W KIM +     N +        + ++L +
Sbjct: 1498 WVYLEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPH 1557

Query: 1277 CNIHLEHIKKSLEDYLEVKRLIFPRFYFLSNAELLDILADSRNPESVQPHLVKCFENIKQ 1336
             +  LE  +KSL  YLE KRL+FPRF+F+S+  LL+IL  + +  ++QPHL    +NI +
Sbjct: 1558 LHEQLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINE 1617

Query: 1337 LLIWKQDIGPPAVKMLISAEGEGLVLPKKIRVRSAVEQWLVNVEK----SMFDVLKKERY 1392
            +    +D     +  +IS EGE +VL   +  +  VE WL+++ K    S+ ++++   Y
Sbjct: 1618 VTFHAKDYD--RIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFY 1675

Query: 1393 IYNI----ILLFQS-----------QIMFYNDCVKSFVSSYSREKLEKVHAGLMCHLEEV 1437
              +     +L F S           Q+++ +D  ++  ++    K+ +V         ++
Sbjct: 1676 QISDSGFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFL---DI 1732

Query: 1438 ADLVVLDTSNSRTK---AILGALLILYVHCRDIVINLLLKNIFNAEDFEWTRHLQYKWNE 1494
             + ++  T++  +K        L+ ++VH RDI  +L+  +I +  DFEW +  ++ + E
Sbjct: 1733 LNTLISQTTHDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKE 1792

Query: 1495 KQKLCYVSQGNASFTYGYEYLGCTSRLVITPLTDRCWLTLMEALHLNLGGCPAGPAGTGK 1554
                  VS  +  F Y  E+LGCT RLVITPLTDRC++TL +AL +N+GG PAGPAGTGK
Sbjct: 1793 DLDQTVVSITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGK 1852

Query: 1555 TETVKDLAKSLGKHCVVFNCFEDLDYKIVRKFFFGLVQSGAWSCFDEFNLIDLEVLSVIA 1614
            TET KD+ + LGK+ VVFNC + +D++ + + F GL QSG+W CFDEFN I+L VLSV A
Sbjct: 1853 TETTKDMGRCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAA 1912

Query: 1615 SQILTIKAAKDNYSARFVL-EGKEIRINMSCAVFITMNPRYGGGVELPDNLKSLFRPVAM 1673
             QI  +  A+     +F+  +G  + +N    +F+TMNP Y G  ELP+NLK  FR VAM
Sbjct: 1913 QQIYIVLTARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAM 1972

Query: 1674 MVPHYQMIAEIILFSFGFKSANSLSGKLTNLYELARKQLSQQDHYNFGLRSLKIVLIMAG 1733
            MVP  Q+I  + L S GF     L+ K   LY+L  +QL++Q HY+FGLR++  VL   G
Sbjct: 1973 MVPDRQIIMRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLG 2032

Query: 1734 TKKREFKCLSEADETLIVIEAIREASLPKCPPEDVPLFENIIGDIFPEVTVLKVNQLALE 1793
            ++KR      E  E  IV+  +R+ +L K   ED PLF ++I D+FP + +       L+
Sbjct: 2033 SQKR---ARPEDSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQ 2089

Query: 1794 KVIYTATQQLGLQNWSSQKEKIIQFYNQLQVCVGVMLVGPTGGGKTTVRRILEKALTLLP 1853
              +    Q  GL N      K++Q Y    V  G+M +GP+G GKTTV  IL KA T   
Sbjct: 2090 NAVAHQVQIEGLINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQT--- 2146

Query: 1854 IADFLSVAERKSASKISERKGKVDICVLNPKCVTLSELYGQLDPNTMEWTDGLLSATIRS 1913
                      +      E +       +NPK +T  +++G+LD  T +WTDG+ S   R 
Sbjct: 2147 ----------ECGRPHREMR-------MNPKAITAPQMFGRLDTATNDWTDGIFSTLWR- 2188

Query: 1914 YVYFNTPKNTKKDIDLRLKSRISDLSNVFKLDSSDTTETDDNIFEEIEKVVKIPENHNFD 1973
                                                            K +K  +  N  
Sbjct: 2189 ------------------------------------------------KTLKAKKGENI- 2199

Query: 1974 WQWIILDGPVDTFWVENLNSVLDDTRTLCLANSERIALTNKIRVIFEVDNLSQASPATVS 2033
              ++ILDGPVD  W+ENLNSVLDD +TL LAN +RI +    +++FEV N+  ASPATVS
Sbjct: 2200 --FLILDGPVDAIWIENLNSVLDDNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVS 2257

Query: 2034 RCAMVYMDPVDLGWEPYVKSWLLK 2057
            R  MVY+    L W P +++WL K
Sbjct: 2258 RMGMVYISSSALSWRPILQAWLKK 2281



 Score =  119 bits (297), Expect = 9e-26
 Identities = 84/284 (29%), Positives = 139/284 (48%), Gaps = 9/284 (3%)

Query: 2390 IPETHKTATGSSDNPTKKPEVRTNKKLLKNNDHKGVVVSTINFSTNVTAAKTKEMILKKL 2449
            I + HK    + +  T K  +   K  LK  D +  +  ++NFS+       +  I   +
Sbjct: 2445 IAKQHKAVLLTGEQGTAKTVMV--KAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYV 2502

Query: 2450 IRRTKDTLGAPKNNRILIFIDDMNMPVSDMYGAQPPLELIRQLLDLGGVYDTEK-NTWKN 2508
             +R   T G P   ++ +FIDD+NMPV + +G Q   E++RQ++++ G+Y  +K   +  
Sbjct: 2503 DKRIGSTYGPPGGRKMTVFIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTT 2562

Query: 2509 IQDLSIVAACVPVV---NDISPRLLKHFSMLVLPHPSQDILCTIFQA-HLGIYFSINNFT 2564
            I D+ ++AA +      NDI  RL + F++     PS   +  IF     G +    +F 
Sbjct: 2563 IVDVQLIAAMIHPGGGRNDIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFK 2622

Query: 2565 PEVQKSKDQIISCSLAIYHQVRQNMLPTPTKCHYMFNLRDMFKLLLGLLQADRTVVNSKE 2624
            P++ +    ++S    ++   +  MLPTP+K HY+FNLRD+ ++  G+L        S  
Sbjct: 2623 PQICEMIVNLVSVGRVLWQWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIP 2682

Query: 2625 MAALLFVHEATRVFHDRLIDFTDKSLFYRLLSRELENCFQIGID 2668
                LF HE +RV  DR I   D+  F   L+R +E    IG D
Sbjct: 2683 TLLSLFKHECSRVIADRFITPEDEQWFNAHLTRAVEE--NIGSD 2724


>gi|114155133 dynein, axonemal, heavy chain 9 isoform 2 [Homo sapiens]
          Length = 4486

 Score =  754 bits (1947), Expect = 0.0
 Identities = 586/2206 (26%), Positives = 1012/2206 (45%), Gaps = 323/2206 (14%)

Query: 2417 LKNNDHKGVVVSTINFSTNVTAAKTKEMILKKLIRRTKDTLGAPKNNRILIFIDDMNMPV 2476
            L + D +  +V  + F+   T+A  + ++ K L ++     G P N +++ FIDDMNMP 
Sbjct: 2492 LASLDPEAYLVKNVPFNYYTTSAMLQAVLEKPLEKKAGRNYGPPGNKKLIYFIDDMNMPE 2551

Query: 2477 SDMYGAQPPLELIRQLLDLGGVYDTEKNTWKNIQDLSIVAACVPVVND--ISPRLLKHFS 2534
             D YG   P  +IRQ LD G  YD  K + K I ++  V+   P      I+PRL +HFS
Sbjct: 2552 VDAYGTVQPHTIIRQHLDYGHWYDRSKLSLKEITNVQYVSCMNPTAGSFTINPRLQRHFS 2611

Query: 2535 MLVLPHPSQDILCTIFQAHLGIYFSINNFTPEVQKSKDQIISCSLAIYHQVRQNMLPTPT 2594
            + VL  P  D L +I+   L  +  + NF   +QKS   +I  +LA + ++    LPT  
Sbjct: 2612 VFVLSFPGADALSSIYSIILTQHLKLGNFPASLQKSIPPLIDLALAFHQKIATTFLPTGI 2671

Query: 2595 KCHYMFNLRDMFKLLLGLLQADRTVVNSKEMAALLFVHEATRVFHDRLIDFTDKSLFYRL 2654
            K HY+FNLRD   +  G+L +    V S      L++HE+ RV+ D++++  D  LF ++
Sbjct: 2672 KFHYIFNLRDFANIFQGILFSSVECVKSTWDLIRLYLHESNRVYRDKMVEEKDFDLFDKI 2731

Query: 2655 LSRELENCFQIGIDGCGKKTCATLACYLTDNKLYRVPISHKCAYIEFKEVFKKVFIHAGL 2714
             +  L+  F    D   +     L C+  +          K   ++  E+  +  + A L
Sbjct: 2732 QTEVLKKTFDDIEDPVEQTQSPNLYCHFANG-----IGEPKYMPVQSWELLTQTLVEA-L 2785

Query: 2715 KGKPTVLMVPNLNIEQDSFLE--DLNYIISSGRIPDLFENV------ELDSIA-----MK 2761
            +    V  V +L + +D+      +N I+ S R   L   V       L  +A     M 
Sbjct: 2786 ENHNEVNTVMDLVLFEDAMRHVCHINRILESPRGNALLVGVGGSGKQSLTRLAAFISSMD 2845

Query: 2762 IRYLTEQSGH--MDNRQSLLSFFQKRIYKNLHIFVIMSPEGPSFRQNCRVYPSMISSCTI 2819
            +  +T + G+   D +  L S   K   KNL+   +M+    +  +   +   +++S  I
Sbjct: 2846 VFQITLRKGYQIQDFKMDLASLCLKAGVKNLNTVFLMTDAQVADERFLVLINDLLASGEI 2905

Query: 2820 -DWYERWPEEALLIVANSFLKEKVNFENREN--------LKEKLAPT------------- 2857
             D Y     E ++    + +K +   +NREN        ++ +L  T             
Sbjct: 2906 PDLYSDDEVENIISNVRNEVKSQGLVDNRENCWKFFIDRIRRQLKVTLCFSPVGNKLRVR 2965

Query: 2858 ---------CVQIH-------KSMKDLNRKYFEETG--------------RFYYTTPN-- 2885
                     C  IH       ++++ ++ ++ + T                F +T+ N  
Sbjct: 2966 SRKFPAIVNCTAIHWFHEWPQQALESVSLRFLQNTEGIEPTVKQSISKFMAFVHTSVNQT 3025

Query: 2886 -----------------SYLQFMETFAHILRAREEEMQTKRDRFHMGLSTILEATTLVTE 2928
                             S+L+F+  +  +L    +E++ K +R   GL  +   +  V +
Sbjct: 3026 SQSYLSNEQRYNYTTPKSFLEFIRLYQSLLHRHRKELKCKTERLENGLLKLHSTSAQVDD 3085

Query: 2929 MQEELLILGPQVEQKTKETETLMEKLRKDSQVVEKVQMLVKQDEEIVAEEVRIVEDYAQK 2988
            ++ +L     +++QK ++ + L++ +  ++  V + + +  ++E+ VA  +  V+   + 
Sbjct: 3086 LKAKLAAQEVELKQKNEDADKLIQVVGVETDKVSREKAMADEEEQKVAVIMLEVKQKQKD 3145

Query: 2989 TANELKSVLPAFDKAIVALNALDKADVAELRVYTRPPFLVLTVMNAVCILL------QKK 3042
               +L    PA   A  ALN L+K ++ EL+ +  PP  V  V  AV +L+       K 
Sbjct: 3146 CEEDLAKAEPALTAAQAALNTLNKTNLTELKSFGSPPLAVSNVSAAVMVLMAPRGRVPKD 3205

Query: 3043 PNWATAKLLLSET-GFLKKLINLDKDSIPDKVFVKLKKIVTLPDFNPHKISLVSVACCSL 3101
             +W  AK+ +++  GFL  LIN +K++I +     ++  +  P+FNP  ++  S A   L
Sbjct: 3206 RSWKAAKVTMAKVDGFLDSLINFNKENIHENCLKAIRPYLQDPEFNPEFVATKSYAAAGL 3265

Query: 3102 CQWVIALNNYHEVQKVVGPKQIQVAEAQNVLKIARQRLAEKQRGLQLVEEHLLFLQAAYK 3161
            C WVI +  ++EV   V PK+  + +A   L  A+++LA  +  +  + E+L  L A ++
Sbjct: 3266 CSWVINIVRFYEVFCDVEPKRQALNKATADLTAAQEKLAAIKAKIAHLNENLAKLTARFE 3325

Query: 3162 DTVAEKQLLANRKTMASRRFQCASVLLTVLEDEKTRWQETINQIDNKLEGILGDILLSAA 3221
               A+K        + +     A+ L+  L  E  RW + +     +   + GDILL  A
Sbjct: 3326 KATADKLKCQQEAEVTAVTISLANRLVGGLASENVRWADAVQNFKQQERTLCGDILLITA 3385

Query: 3222 CIVYSGILTPEFRQLIVNK-WETFC--IENGISLSSKFSLIKVMAQKYEISRWHNQGLPH 3278
             I Y G  T ++RQ ++++ W  +   ++  I ++     ++++    +++ W N+GLP 
Sbjct: 3386 FISYLGFFTKKYRQSLLDRTWRPYLSQLKTPIPVTPALDPLRMLMDDADVAAWQNEGLPA 3445

Query: 3279 GQYSVENAILIKNGQQWPLLIDPHRQAHKWIRQMEGSRLQKLSIEDSNYTKKIENAMKTG 3338
             + SVENA ++ N ++WPL++DP  Q  KWI+   G  L+   I    Y + IE A++ G
Sbjct: 3446 DRMSVENATILINCERWPLMVDPQLQGIKWIKNKYGEDLRVTQIGQKGYLQIIEQALEAG 3505

Query: 3339 GSVLLQNLLETLAPGLKAILKKDIYQKKGHYFIRVGDAEFEYNSNFRLYLSTEIDNPHFL 3398
              VL++NL E++ P L  +L +++  KKG  FI++GD E EYN  FRL L T++ NPH+ 
Sbjct: 3506 AVVLIENLEESIDPVLGPLLGREVI-KKGR-FIKIGDKECEYNPKFRLILHTKLANPHYQ 3563

Query: 3399 PSVYNFVTMINFTVTFQGLQDQLLSTVVTHEVPHLEDQRSKLLESISLDAITLEELEEKT 3458
            P +    T+INFTVT  GL+DQLL+ VV+ E P LE  +S L +  +   ITL+ LE+  
Sbjct: 3564 PELQAQATLINFTVTRDGLEDQLLAAVVSMERPDLEQLKSDLTKQQNGFKITLKTLEDSL 3623

Query: 3459 LNLLQKALGSILDDDKIVDTLRKSKMTSNEISKRIEATKKAESEIQAIRKNYLPIATRGA 3518
            L+ L  A G+ L +  +V+ L  +K T+ E+ K+++  K  E +I   R++Y P A R +
Sbjct: 3624 LSRLSSASGNFLGETVLVENLEITKQTAAEVEKKVQEAKVTEVKINEAREHYRPAAARAS 3683

Query: 3519 LLYFLVADLTQINYMYQFSLDWFHQVFVSSVVSKSKEQEHSFKREKVSPKEVHEFISISK 3578
            LLYF++ DL++I+ MYQFSL  F  VF  +V             E+ +P E         
Sbjct: 3684 LLYFIMNDLSKIHPMYQFSLKAFSIVFQKAV-------------ERAAPDE--------- 3721

Query: 3579 EPNLENEKNLLDKHIKSAIDMLTKSIFKVVSSALFNEDKLCFSFRLCTVIMQNNANGNLI 3638
                      L + + + ID +T S+++     LF  DKL +  +L   I+  N   N +
Sbjct: 3722 ---------SLRERVANLIDSITFSVYQYTIRGLFECDKLTYLAQLTFQILLMNREVNAV 3772

Query: 3639 QDDIGFLPEEEWNIFLYSGILINIKSALSQSRLTSTFEIGESQHLQWLSDSRWRQCQYVS 3698
            + D  FL                         L S  + G +  +++LS   W   + +S
Sbjct: 3773 ELD--FL-------------------------LRSPVQTGTASPVEFLSHQAWGAVKVLS 3805

Query: 3699 THLEPFSLLCKSLLSNVSQWDTFKNSKAVYSLISTPFSSENASLEENTKPPEETELLNEN 3758
            + +E FS L + +  +   W  F  S+                  E  K P+E       
Sbjct: 3806 S-MEEFSNLDRDIEGSAKSWKKFVESEC----------------PEKEKLPQE------- 3841

Query: 3759 KETCNPINFPWEKLTSFQRLILVKVLRPESLNNSVRKFITEKMGNKYLQRTGVNLKDAYK 3818
                      W+  T+ QRL +++ +RP+ +  ++R F+ EK+G+KY+    ++   +++
Sbjct: 3842 ----------WKNKTALQRLCMLRAMRPDRMTYALRDFVEEKLGSKYVVGRALDFATSFE 3891

Query: 3819 GSNARTPLILIQTHGIDLTNILLRFAQELKGTTHHVTI--ISLGRDQAAKAEDLILKALT 3876
             S   TP+  I + G+D    +    ++L  T ++     +SLG+ Q   AE   L    
Sbjct: 3892 ESGPATPMFFILSPGVDPLKDVESQGRKLGYTFNNQNFHNVSLGQGQEVVAE-AALDLAA 3950

Query: 3877 KTQQWVFLQNCHLATSFMPRLCTIVESFNSPNVTIDPEFRLWLSSKSYSS-----FPIPV 3931
            K   WV LQN HL   +   L T+ +     +    PEFR+++S++   S      P  +
Sbjct: 3951 KKGHWVILQNIHLVAKW---LSTLEKKLEEHSENSHPEFRVFMSAEPAPSPEGHIIPQGI 4007

Query: 3932 LKKGLKIAVESPQGLKSNLLQTFGCTGSGEVTEEIFENPDCGQWWKKLLFSLCFFNAVIN 3991
            L+  +KI  E P G+ +NL +          T++  E       +K +LF+LC+F+AV+ 
Sbjct: 4008 LENSIKITNEPPTGMHANLHKAL-----DNFTQDTLEMCSRETEFKSILFALCYFHAVVA 4062

Query: 3992 ERKNYGILGWNIAYKFNSSDLGVAIKVLENSLRGQPSISWQALRYLIGEVIYGGRVIDNW 4051
            ER+ +G  GWN +Y FN+ DL +++ VL N L     + +  LRYL GE++YGG + D+W
Sbjct: 4063 ERRKFGPQGWNRSYPFNTGDLTISVNVLYNFLEANAKVPYDDLRYLFGEIMYGGHITDDW 4122

Query: 4052 DKRCLKTLLYKFCNPEVLKDDFSFS------RSASIKDYIHIIQSLPDDDLPEVLGIHPE 4105
            D+R  +T L +F  PE+L+ + S +       +     Y   I +    + P + G+HP 
Sbjct: 4123 DRRLCRTYLGEFIRPEMLEGELSLAPGFPLPGNMDYNGYHQYIDAELPPESPYLYGLHPN 4182

Query: 4106 AIRSCWETQGEKFIENLIAMQPKTTTANLMIRPEQSKDELVMEILSDLLKRLPLTVEKEE 4165
            A         EK    ++ +QP+ + A        +++E V  +L ++L+R+      +E
Sbjct: 4183 AEIGFLTQTSEKLFRTVLELQPRDSQAR--DGAGATREEKVKALLEEILERV-----TDE 4235

Query: 4166 IAVGTPSTLKSMMSSSIWESLSKNLKDHDPLIHCVLLTFLKQEIKRFDKLLFVIHKSLKD 4225
              +                 L   +++  P I   ++ F  QE  R + L   I +SL++
Sbjct: 4236 FNI---------------PELMAKVEERTPYI---VVAF--QECGRMNILTREIQRSLRE 4275

Query: 4226 LQLAIKGEIILTQELEEIFNSFLNMRVPTLWQKHAYRSCKPLSSWIDDLIQRLNFFNTWA 4285
            L+L +KGE+ +T  +E + N+     VP  W + AY S   L++W  DL+ R+     W 
Sbjct: 4276 LELGLKGELTMTSHMENLQNALYFDMVPESWARRAYPSTAGLAAWFPDLLNRIKELEAWT 4335

Query: 4286 KVAYTAIQRRYMRFVTVWKQSIPSTSQKCKHPEDSENNFFEGFPSRYWLPAFFFPQAFLA 4345
                                                 +F    PS  WL  FF PQ+FL 
Sbjct: 4336 ------------------------------------GDF--TMPSTVWLTGFFNPQSFLT 4357

Query: 4346 AVLQDYGRSRGIAVDALTFTHHVISNTTDKDEKFSVFMPKKLNIVRRAFKGSASSHTGVY 4405
            A++Q   R     +D +        + T K+              R  F+  +    G Y
Sbjct: 4358 AIMQSTARKNEWPLDQMALQ----CDMTKKN--------------REEFR--SPPREGAY 4397

Query: 4406 IFGLFIEGARWNREQKILEDSLPLEMCCDFPDIYFLPTKISTKTPNASNQTDSELYAFEC 4465
            I GLF+EGA W+ +  I+ ++   ++    P ++        K   A  Q    +Y+  C
Sbjct: 4398 IHGLFMEGACWDTQAGIITEAKLKDLTPPMPVMFI-------KAIPADKQDCRSVYS--C 4448

Query: 4466 PVYQTPERSRILATTGLPTNFLTSVYLSTKKPPSHWITMRVALLCE 4511
            PVY+T +R         PT ++ +  L TK+ PS W+   VALL +
Sbjct: 4449 PVYKTSQRG--------PT-YVWTFNLKTKENPSKWVLAGVALLLQ 4485



 Score =  620 bits (1600), Expect = e-177
 Identities = 426/1423 (29%), Positives = 692/1423 (48%), Gaps = 206/1423 (14%)

Query: 963  QDCFSDSQSHMHSVNVEEITQIVLSEISDIEGDLTLRKKLWEAQEEWKRASWEWRNSSLQ 1022
            Q   S   S   S ++ E+      ++     ++   K+LW+       +   W  +  +
Sbjct: 1266 QQMESTMASISESASLFEVNVPDYKQLRQCRKEVCQLKELWDTIGMVTSSIHAWETTPWR 1325

Query: 1023 SIDVESVQRNVSKLMHIISVLEKGLPKSDMVTHLKQVVTEFKQELPIIIALGNPCLKPRH 1082
            +I+VE+++    +    I  L+K +   D  T L+  V      L  +  L NP ++ RH
Sbjct: 1326 NINVEAMELECKQFARHIRNLDKEVRAWDAFTGLESTVWNTLSSLRAVAELQNPAIRERH 1385

Query: 1083 WEALQEIIGKSVPLDKNCKVENLLALKMFQYENEINDMSTSATNEAALEKMLFKIIDFWN 1142
            W  L +  G S  +D++  + +LL L++  YE+E+  +   A  E  +EK L ++   W 
Sbjct: 1386 WRQLMQATGVSFTMDQDTTLAHLLQLQLHHYEDEVRGIVDKAAKEMGMEKTLKELQTTWA 1445

Query: 1143 TTPLPLILHHTEIYSIFIIPSIDDISAQLEESQVILATIKGSPHIGPIKDLVNEWDQNLT 1202
                    H     ++ ++ S +D+   LE++QV L  +  S ++    + V+ W + L+
Sbjct: 1446 GMEFQYEPHPRT--NVPLLCSDEDLIEVLEDNQVQLQNLVMSKYVAFFLEEVSGWQKKLS 1503

Query: 1203 LFSYTLEEWMNCQRNWLYLEPVFHSSE-IRRQLPAETELFSQVISMWKKIMSKIQNKQNA 1261
                 +  W   QR W +LE +F  SE IR QLP +++ F  +   +K++    Q   N 
Sbjct: 1504 TVDAVISIWFEVQRTWTHLESIFTGSEDIRAQLPQDSKRFEGIDIDFKELAYDAQKIPNV 1563

Query: 1262 LQITTSAGVLEILQNCNIHLEHIKKSLEDYLEVKRLIFPRFYFLSNAELLDILADSRNPE 1321
            +Q T   G+ E L++    L   +K+L +YL+ KRL FPRFYFLS+++LLDIL++   P+
Sbjct: 1564 VQTTNKPGLYEKLEDIQGRLCLCEKALAEYLDTKRLAFPRFYFLSSSDLLDILSNGTAPQ 1623

Query: 1322 SVQPHLVKCFENIKQLLIWKQDIGPPAVKML--ISAEGEGLVLPKKIRVRSAVEQWLVNV 1379
             VQ HL K F+N+ ++       G P    L   S E E +   +       VE WL +V
Sbjct: 1624 QVQRHLSKLFDNMAKMRFQLDASGEPTKTSLGMYSKEEEYVAFSEPCDCSGQVEIWLNHV 1683

Query: 1380 EKSM--------------FDVLKKERYIYNI---ILLFQSQIMFYNDCVKSF--VSSYSR 1420
               M              ++   +E+++++    + L  +QI +  +   +F  +     
Sbjct: 1684 LGHMKATVRHEMTEGVTAYEEKPREQWLFDHPAQVALTCTQIWWTTEVGMAFARLEEGYE 1743

Query: 1421 EKLEKVHAGLMCHLEEVADLVVLDTSNSRTKAILGALLILYVHCRDIVINLLLKNIFNAE 1480
              ++  +   +  L+ +  +++   S    + I+  +  + VH RD+V  ++ + + NA+
Sbjct: 1744 SAMKDYYKKQVAQLKTLITMLIGQLSKGDRQKIM-TICTIDVHARDVVAKMIAQKVDNAQ 1802

Query: 1481 DFEWTRHLQYKWNEKQKLCYVSQGNASFTYGYEYLGCTSRLVITPLTDRCWLTLMEALHL 1540
             F W   L+++W+++ K C+ +  +A F Y YEYLG T RLVITPLTDRC++TL ++LHL
Sbjct: 1803 AFLWLSQLRHRWDDEVKHCFANICDAQFLYSYEYLGNTPRLVITPLTDRCYITLTQSLHL 1862

Query: 1541 NLGGCPAGPAGTGKTETVKDLAKSLGKHCVVFNCFEDLDYKIVRKFFFGLVQSGAWSCFD 1600
             + G PAGPAGTGKTET KDL ++LG    VFNC E +DYK     + GL Q+GAW CFD
Sbjct: 1863 TMSGAPAGPAGTGKTETTKDLGRALGILVYVFNCSEQMDYKSCGNIYKGLAQTGAWGCFD 1922

Query: 1601 EFNLIDLEVLSVIASQILTIKAAKDNYSARFVLEGKEIRINMSCAVFITMNPRYGGGVEL 1660
            EFN I +EVLSV+A Q+ +I+ A  +    F   G+EI +N S  +FITMNP Y G  EL
Sbjct: 1923 EFNRISVEVLSVVAVQVKSIQDAIRDKKQWFSFLGEEISLNPSVGIFITMNPGYAGRTEL 1982

Query: 1661 PDNLKSLFRPVAMMVPHYQMIAEIILFSFGFKSANSLSGKLTNLYELARKQLSQQDHYNF 1720
            P+NLKSLFRP AM+VP +++I EI+L + GF  A SL+ K   LY+L ++ LS+QDHY++
Sbjct: 1983 PENLKSLFRPCAMVVPDFELICEIMLVAEGFIEAQSLARKFITLYQLCKELLSKQDHYDW 2042

Query: 1721 GLRSLKIVLIMAGTKKREFKCLSEADETLIVIEAIREASLPKCPPEDVPLFENIIGDIFP 1780
            GLR++K VL++AG+ KR      +  E  +++ ++R+ ++PK   +D+P+F  +IGD+FP
Sbjct: 2043 GLRAIKSVLVVAGSLKRGD---PDRPEDQVLMRSLRDFNIPKIVTDDMPIFMGLIGDLFP 2099

Query: 1781 EVTVLKVNQLALEKVIYTATQQLGLQNWSSQKEKIIQFYNQLQVCVGVMLVGPTGGGKTT 1840
             + V +      E ++  A   L LQ   +   K++Q    L V   V +VG  G GK+ 
Sbjct: 2100 ALDVPRRRDPNFEALVRKAIVDLKLQAEDNFVLKVVQLEELLAVRHSVFVVGGAGTGKSQ 2159

Query: 1841 VRRILEKALTLLPIADFLSVAERKSASKISERKGKVDICVLNPKCVTLSELYGQLDPNTM 1900
            V R L K   ++                    K +     LNPK VT  EL+G ++P T 
Sbjct: 2160 VLRSLHKTYQIM--------------------KRRPVWTDLNPKAVTNDELFGIINPATG 2199

Query: 1901 EWTDGLLSATIRSYVYFNTPKNTKKDIDLRLKSRISDLSNVFKLDSSDTTETDDNIFEEI 1960
            EW DGL S+ +R                        +L+N+          T D      
Sbjct: 2200 EWKDGLFSSIMR------------------------ELANI----------THDGP---- 2221

Query: 1961 EKVVKIPENHNFDWQWIILDGPVDTFWVENLNSVLDDTRTLCLANSERIALTNKIRVIFE 2020
                          +WI+LDG +D  W+E+LN+V+DD + L LA++ERI L   ++++FE
Sbjct: 2222 --------------KWILLDGDIDPMWIESLNTVMDDNKVLTLASNERIPLNPTMKLLFE 2267

Query: 2021 VDNLSQASPATVSRCAMVYMDPVDLGWEPYVKSWLLKTSKIISQSGVDCLEFMIKNSVTD 2080
            + +L  A+PATVSR  ++Y++P DLGW P V SW+ K      ++    L  +    +  
Sbjct: 2268 ISHLRTATPATVSRAGILYINPADLGWNPPVSSWIEKREIQTERAN---LTILFDKYLPT 2324

Query: 2081 GLQFIRNRQKFQPYPMEDITVVITLCRILDAFFDFMGKNGGFEQSDDLNDTSSKEANSQR 2140
             L  +R R K +  P+ + ++V  +C +L+                              
Sbjct: 2325 CLDTLRTRFK-KIIPIPEQSMVQMVCHLLECL---------------------------- 2355

Query: 2141 ESVTFKDIEKRDENTWYPEKNPDKLTKIIQKLFVFAFTWAFGGALNREDEHRENIPFCPS 2200
              +T +DI              D   +I +  FVFA  WAFGGA+ +             
Sbjct: 2356 --LTTEDIP------------ADCPKEIYEHYFVFAAIWAFGGAMVQ------------- 2388

Query: 2201 LEPDSLAKVTYDFDKLVHELFGNSSQVGWKHWGQSQGRRRKGNCINLPTGECSIFGYFVD 2260
               D L     +F K                W  ++ +      +  P+ + +IF Y++D
Sbjct: 2389 ---DQLVDYRAEFSK----------------WWLTEFK-----TVKFPS-QGTIFDYYID 2423

Query: 2261 IEQCEFIPWSDLVPNDQTLIQRGTSLLTNLQRSGGNFLKITECGECINYTATRDTTCLSF 2320
             E  +F PWS LVP  +                   F        C+ +T+  +T  + +
Sbjct: 2424 PETKKFEPWSKLVPQFE-------------------FDPEMPLQACLVHTS--ETIRVCY 2462

Query: 2321 LMSLLLKNSCPVLLTGESGVGKTAAINQMLEKLEGPGAFDIKH 2363
             M  L+    PV+L G +G GK+  +   L  L+ P A+ +K+
Sbjct: 2463 FMERLMARQRPVMLVGTAGTGKSVLVGAKLASLD-PEAYLVKN 2504


>gi|51479173 dynein, axonemal, heavy chain 11 [Homo sapiens]
          Length = 4523

 Score =  743 bits (1919), Expect = 0.0
 Identities = 519/1875 (27%), Positives = 897/1875 (47%), Gaps = 241/1875 (12%)

Query: 2665 IGIDGCGKKTCATLACYLTDNKLYRVPISHKCAYIEFKEVFKKVFIHAGLKGKPTVLMVP 2724
            +G+ G GK++ + LA YL   +++++ ++      E +     ++I  G K  PTV ++ 
Sbjct: 2861 VGVGGSGKQSLSRLAAYLRGLEVFQITLTEGYGIQELRVDLANLYIRTGAKNMPTVFLLT 2920

Query: 2725 NLNIEQDSFLEDLNYIISSGRIPDLFENVELDSIAMKIRYLTEQSGHMDNRQSLLSFFQK 2784
            +  +  +SFL  +N +++SG IPDLF + ++D I   I       G +D+R++   FF  
Sbjct: 2921 DAQVLDESFLVLINDLLASGEIPDLFSDEDVDKIISGIHNEVHALGMVDSRENCWKFFMA 2980

Query: 2785 RIYKNLHIFVIMSPEGPSFRQNCRVYPSMISSCTIDWYERWPEEALLIVANSFLKEKVNF 2844
            R+   L I +  SP G + R   R +P++++   IDW+  WP+EAL+ V+  F++E    
Sbjct: 2981 RVRLQLKIILCFSPVGRTLRVRARKFPAIVNCTAIDWFHAWPQEALVSVSRRFIEETKGI 3040

Query: 2845 ENRENLKEKLAPTCVQIHKSMKDLNRKYFEETGRFYYTTPNSYLQFMETFAHILRAREEE 2904
            E     K+ ++     +H ++ +++ +Y++   R  YTTP S+L+ +  F ++L+ ++ E
Sbjct: 3041 EPVH--KDSISLFMAHVHTTVNEMSTRYYQNERRHNYTTPKSFLEQISLFKNLLKKKQNE 3098

Query: 2905 MQTKRDRFHMGLSTILEATTLVTEMQEELLILGPQVEQKTKETETLMEKLRKDSQVVEKV 2964
            +  K++R   G+  +    + V +++  L     +++ +  + E L+ K+   ++ V + 
Sbjct: 3099 VSEKKERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIGLQTEKVSRE 3158

Query: 2965 QMLVKQDE-EIVAEEVRIVEDYAQKTANELKSVLPAFDKAIVALNALDKADVAELRVYTR 3023
            + +   +E ++ A +  + +   +  A+ LK+  PA   A  ALN L++ +++EL+ +  
Sbjct: 3159 KTIADAEERKVTAIQTEVFQKQRECEADLLKAE-PALVAATAALNTLNRVNLSELKAFPN 3217

Query: 3024 PPFLVLTVMNAVCILLQ------KKPNWATAKLLLSETG-FLKKLINLDKDSIPDKVF-V 3075
            PP  V  V  AV +LL       K  +W  AK+ + +   FL+ LIN DK+ IP+    V
Sbjct: 3218 PPIAVTNVTAAVMVLLAPRGRVPKDRSWKAAKVFMGKVDDFLQALINYDKEHIPENCLKV 3277

Query: 3076 KLKKIVTLPDFNPHKISLVSVACCSLCQWVIALNNYHEVQKVVGPKQIQVAEAQNVLKIA 3135
              +  +  P+FNP+ I   S A   LC WVI +  ++EV   V PK+  +A+A   L  A
Sbjct: 3278 VNEHYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCDVEPKRQALAQANLELAAA 3337

Query: 3136 RQRLAEKQRGLQLVEEHLLFLQAAYKDTVAEKQLLANRKTMASRRFQCASVLLTVLEDEK 3195
             ++L   ++ L  ++ +L  L A+++   AEK          ++  + A+ L+  LE +K
Sbjct: 3338 TEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKK 3397

Query: 3196 TRWQETINQIDNKLEGILGDILLSAACIVYSGILTPEFRQLIVN-KWETFCIEN-GISLS 3253
             RW ++I   + + + + GD+LL+AA + Y G  T ++RQ +V+ KW  F  +   I L+
Sbjct: 3398 IRWGQSIKSFEAQEKTLCGDVLLTAAFVSYVGPFTRQYRQELVHCKWVPFLQQKVSIPLT 3457

Query: 3254 SKFSLIKVMAQKYEISRWHNQGLPHGQYSVENAILIKNGQQWPLLIDPHRQAHKWIRQME 3313
                LI ++     I+ W+N+GLP  + S ENA ++ + ++WPL+IDP +Q  KWI+   
Sbjct: 3458 EGLDLISMLTDDATIAAWNNEGLPSDRMSTENAAILTHCERWPLVIDPQQQGIKWIKNKY 3517

Query: 3314 GSRLQKLSIEDSNYTKKIENAMKTGGSVLLQNLLETLAPGLKAILKKDIYQKKGHYFIRV 3373
            G  L+   +    +   IE A+  G  +L++NL ET+ P L  +L ++   KKG Y IR+
Sbjct: 3518 GMDLKVTHLGQKGFLNAIETALAFGDVILIENLEETIDPVLDPLLGRNTI-KKGKY-IRI 3575

Query: 3374 GDAEFEYNSNFRLYLSTEIDNPHFLPSVYNFVTMINFTVTFQGLQDQLLSTVVTHEVPHL 3433
            GD E E+N NFRL L T++ NPH+ P +    T++NFTVT  GL+ QLL+ VV+ E P L
Sbjct: 3576 GDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEAQLLAEVVSIERPDL 3635

Query: 3434 EDQRSKLLESISLDAITLEELEEKTLNLLQKALGSILDDDKIVDTLRKSKMTSNEISKRI 3493
            E  +  L +  +   I L+ LE+  L  L  A GS LDD K+V+ L  +K T  EI  ++
Sbjct: 3636 EKLKLVLTKHQNDFKIELKYLEDDLLLRLSAAEGSFLDDTKLVERLEATKTTVAEIEHKV 3695

Query: 3494 EATKKAESEIQAIRKNYLPIATRGALLYFLVADLTQINYMYQFSLDWFHQVFVSSVVSKS 3553
               K+ E +I   R+ Y P+A R +LLYF++ DL +IN +YQFSL  F+ +F  ++    
Sbjct: 3696 IEAKENERKINEARECYRPVAARASLLYFVINDLQKINPLYQFSLKAFNVLFHRAIEQAD 3755

Query: 3554 KEQEHSFKREKVSPKEVHEFISISKEPNLENEKNLLDKHIKSAIDMLTKSIFKVVSSALF 3613
            K ++                               +   I   ++ +T ++F   S ALF
Sbjct: 3756 KVED-------------------------------MQGRISILMESITHAVFLYTSQALF 3784

Query: 3614 NEDKLCFSFRLCTVIMQNNANGNLIQDDIGFLPEEEWNIFLYSGILINIKSALSQSRLTS 3673
             +DKL F  ++   I+      + ++ D  FL                         L  
Sbjct: 3785 EKDKLTFLSQMAFQILLRKKEIDPLELD--FL-------------------------LRF 3817

Query: 3674 TFEIGESQHLQWLSDSRWRQCQYVSTHLEPFSLLCKSLLSNVSQWDTFKNSKAVYSLIST 3733
            T E      + +L+   W   + ++  +E F  + + +  +  QW  +  S+        
Sbjct: 3818 TVEHTHLSPVDFLTSQSWSAIKAIAV-MEEFRGIDRDVEGSAKQWRKWVESEC------- 3869

Query: 3734 PFSSENASLEENTKPPEETELLNENKETCNPINFPWEKLTSFQRLILVKVLRPESLNNSV 3793
                      E  K P+E                 W+K +  Q+LIL++ +RP+ +  ++
Sbjct: 3870 ---------PEKEKLPQE-----------------WKKKSLIQKLILLRAMRPDRMTYAL 3903

Query: 3794 RKFITEKMGNKYLQRTGVNLKDAYKGSNARTPLILIQTHGIDLTNILLRFAQEL-----K 3848
            R F+ EK+G KY++RT ++L  A++ S+  TP+  I + G+D    L    + L      
Sbjct: 3904 RNFVEEKLGAKYVERTRLDLVKAFEESSPATPIFFILSPGVDALKDLEILGKRLGFTIDS 3963

Query: 3849 GTTHHVTIISLGRDQAAKAEDLILKALTKTQQWVFLQNCHLATSFMPRLCTIVESFNSPN 3908
            G  H+V   SLG+ Q   AE  + KA +K   WV LQN HL   ++  L  ++E F+  +
Sbjct: 3964 GKFHNV---SLGQGQETVAEVALEKA-SKGGHWVILQNVHLVAKWLGTLEKLLERFSQGS 4019

Query: 3909 VTIDPEFRLWLSSKSYSS-----FPIPVLKKGLKIAVESPQGLKSNLLQTFGCTGSGEVT 3963
                 ++R+++S++S  +      P  +L+  +KI  E P G+ +NL             
Sbjct: 4020 ---HRDYRVFMSAESAPTPDEHIIPQGLLENSIKITNEPPTGMLANLHAAL-----YNFD 4071

Query: 3964 EEIFENPDCGQWWKKLLFSLCFFNAVINERKNYGILGWNIAYKFNSSDLGVAIKVLENSL 4023
            ++  E     Q +K +LFSLC+F+A +  R  +G  GW+ +Y FN  DL +   VL N L
Sbjct: 4072 QDTLEICSKEQEFKSILFSLCYFHACVAGRLRFGPQGWSRSYPFNPGDLTICASVLYNYL 4131

Query: 4024 RGQPSISWQALRYLIGEVIYGGRVIDNWDKRCLKTLLYKFCNPEVLKDDFSFSRSASIKD 4083
                 + W+ LRYL GE++YGG + D+WD++  +  L +F NP + +D+   +   +   
Sbjct: 4132 EANSKVPWEDLRYLFGEIMYGGHITDDWDRKLCRVYLEEFMNPSLTEDELMLAPGFAAPP 4191

Query: 4084 YI-------HIIQSLPDDDLPEVLGIHPEAIRSCWETQGEKFIENLIAMQPKTTTANLMI 4136
            Y+       +I + LP +  P + G+HP A               L+ MQP+   +   +
Sbjct: 4192 YLDYAGYHQYIEEMLPPES-PALYGLHPNAEIEFLTVTSNTLFRTLLEMQPRNALSGDEL 4250

Query: 4137 RPEQSKDELVMEILSDLLKRLPLTVEKEEIAVGTPSTLKSMMSSSIWESLSKNLKDHDPL 4196
               QS +E V  +L D+L++LP      EI                   + KN      +
Sbjct: 4251 --GQSTEEKVKNVLDDILEKLPEEFNMAEI-------------------MQKNSNRSPYV 4289

Query: 4197 IHCVLLTFLKQEIKRFDKLLFVIHKSLKDLQLAIKGEIILTQELEEIFNSFLNMRVPTLW 4256
            + C       QE +R + L+  I  SL+ L L++KGE+ L+  +E    +     VP  W
Sbjct: 4290 LVCF------QECERMNILIREIRISLEQLDLSLKGELALSPAVEAQQFALSYDTVPDTW 4343

Query: 4257 QKHAYRSCKPLSSWIDDLIQRLNFFNTWAKVAYTAIQRRYMRFVTVWKQSIPSTSQKCKH 4316
             K AY S   L+ W +DL+ R    +TW +                              
Sbjct: 4344 SKLAYPSTYGLAQWFNDLLLRCRELDTWTQDL---------------------------- 4375

Query: 4317 PEDSENNFFEGFPSRYWLPAFFFPQAFLAAVLQDYGRSRGIAVDALTFTHHVISNTTDKD 4376
                        P+  WL  FF PQ+FL A++Q   R     +D    T    ++ T K 
Sbjct: 4376 ----------TLPAVVWLSGFFNPQSFLTAIMQTMARKNEWPLDKTRLT----ADVTKKT 4421

Query: 4377 EKFSVFMPKKLNIVRRAFKGSASSHTGVYIFGLFIEGARWNREQKILEDSLPLEMCCDFP 4436
            ++     P++                G Y+ GLF+EGARW+ +   + ++   E+ C  P
Sbjct: 4422 KEDYGHPPRE----------------GAYLHGLFMEGARWDTQAGTIVEARLKELACPMP 4465

Query: 4437 DIYFLPTKISTKTPNASNQTDSELYAFECPVYQTPERSRILATTGLPTNFLTSVYLSTKK 4496
             I+   T +  +    + QT      +ECPVY+T  R           +++ +  L +++
Sbjct: 4466 VIFAKATPVDRQ---ETKQT------YECPVYRTKLRG---------PSYIWTFRLKSEE 4507

Query: 4497 PPSHWITMRVALLCE 4511
              + W+   VALL E
Sbjct: 4508 KTAKWVLAGVALLLE 4522



 Score =  625 bits (1613), Expect = e-178
 Identities = 441/1410 (31%), Positives = 681/1410 (48%), Gaps = 208/1410 (14%)

Query: 975  SVNVEEITQIVLSEISDIEGDLTLRKKLWEAQEEWKRA--SW---EWRNSSLQSIDVESV 1029
            S  + E+      ++     ++ L K LW+     +R+  +W   +WR   ++ +DVE  
Sbjct: 1302 STRLFEVALPEYKQMKQCRKEIKLLKGLWDVIIYVRRSIDNWTKTQWRQIHVEQMDVEL- 1360

Query: 1030 QRNVSKLMHIISV--LEKGLPKSDMVTHLKQVVTEFKQELPIIIALGNPCLKPRHWEALQ 1087
             R  +K   I  +  L K +   D  T L+  V +    L  I  L +P L+ RHW  L 
Sbjct: 1361 -RRFAKASSITEIWSLNKEVRVWDAYTGLEGTVKDMTASLRAITELQSPALRDRHWHQLM 1419

Query: 1088 EIIGKSVPLDKNCKVENLLALKMFQYENEINDMSTSATNEAALEKMLFKIIDFWNTTPLP 1147
            + IG    +++   + +LLAL++ + E+++  +   A  E   EK++ +I   W T    
Sbjct: 1420 KAIGVKFLINEATTLADLLALRLHRVEDDVRRIVDKAVKELGTEKVITEISQTWATMKFS 1479

Query: 1148 LILHHTEIYSIFIIPSIDDISAQLEESQVILATIKGSPHIGPIKDLVNEWDQNLTLFSYT 1207
              +H+     I ++ S + +   LE +QV L T+  S ++    + V  W   L +    
Sbjct: 1480 YEVHYRT--GIPLLKSDEQLFETLEHNQVQLQTLLQSKYVEYFIEQVLSWQNKLNIADLV 1537

Query: 1208 LEEWMNCQRNWLYLEPVFHSSE-IRRQLPAETELFSQVISMWKKIMSKIQNKQNALQITT 1266
            +  WM  QR W +LE +F  SE IR QL  +   F  V + +K++M K    +N L+ T 
Sbjct: 1538 IFTWMEVQRTWSHLESIFVCSEDIRIQLVKDARRFDGVDAEFKELMFKTAKVENVLEATC 1597

Query: 1267 SAGVLEILQNCNIHLEHIKKSLEDYLEVKRLIFPRFYFLSNAELLDILADSRNPESVQPH 1326
               + E L++    L   +K+L +YLE KR+ FPRFYF+S+A+LLDIL+    P+ V  H
Sbjct: 1598 RPNLYEKLKDLQSRLSLCEKALAEYLETKRIAFPRFYFVSSADLLDILSKGAQPKQVTCH 1657

Query: 1327 LVKCFENIKQLLIW-KQDIGPPAVKMLISAEGEGLVLPKKIRVRSAVEQWLVNVEKSMFD 1385
            L K F++I  L     QD+       + S E E +    +      VE WL+ +E++M +
Sbjct: 1658 LAKLFDSIADLQFEDNQDVSAHRAVGMYSKEKEYVPFQAECECVGHVETWLLQLEQTMQE 1717

Query: 1386 VLK--------------KERYIYNI---ILLFQSQIMFYNDCVKSF--VSSYSREKLEKV 1426
             ++              +E +I++    + L  SQI +  D   +F  +       L+  
Sbjct: 1718 TVRHSITEAIVAYEEKPRELWIFDFPAQVALTSSQIWWTTDVGIAFSRLEEGYETALKDF 1777

Query: 1427 HAGLMCHLEEVADLVVLDTSNSRTKAILGALLILYVHCRDIVINLLLKN--IFNAEDFEW 1484
            H   +  L  +  L++ +      + I+  +  + VH RD+V  L+ +   + + + F W
Sbjct: 1778 HKKQISQLNTLITLLLGELPPGDRQKIM-TICTIDVHARDVVAKLISQKQVVVSPQAFTW 1836

Query: 1485 TRHLQYKWNEKQKLCYVSQGNASFTYGYEYLGCTSRLVITPLTDRCWLTLMEALHLNLGG 1544
               L+++W + QK C+V+  +A F Y YEYLG + RLVITPLTDRC++TL ++LHL + G
Sbjct: 1837 LSQLRHRWEDTQKHCFVNICDAQFQYFYEYLGNSPRLVITPLTDRCYITLTQSLHLTMSG 1896

Query: 1545 CPAGPAGTGKTETVKDLAKSLGKHCVVFNCFEDLDYKIVRKFFFGLVQSGAWSCFDEFNL 1604
             PAGPAGTGKTET KDL ++LG    VFNC E +DYK +   + GLVQ+GAW CFDEFN 
Sbjct: 1897 APAGPAGTGKTETTKDLGRALGMMVYVFNCSEQMDYKSIGNIYKGLVQTGAWGCFDEFNR 1956

Query: 1605 IDLEVLSVIASQILTIKAAKDNYSARFVLEGKEIRINMSCAVFITMNPRYGGGVELPDNL 1664
            I +EVLSV+A Q+  I  A  N   RFV  G+ I +  S  +FITMNP Y G  ELP+NL
Sbjct: 1957 ISVEVLSVVAVQVKMIHDAIRNRKKRFVFLGEAITLKPSVGIFITMNPGYAGRTELPENL 2016

Query: 1665 KSLFRPVAMMVPHYQMIAEIILFSFGFKSANSLSGKLTNLYELARKQLSQQDHYNFGLRS 1724
            K+LFRP AM+ P  ++I EI+L + GF  A +L+ K   LY L ++ LS+QDHY++GLR+
Sbjct: 2017 KALFRPCAMVAPDIELICEILLVAEGFVDARALARKFITLYTLCKELLSKQDHYDWGLRA 2076

Query: 1725 LKIVLIMAGTKKREFKCLSEADETLIVIEAIREASLPKCPPEDVPLFENIIGDIFPEVTV 1784
            +K VL++AG+ KR  K      E  +++ A+R+ ++PK   +D+P+F  ++GD+FP + V
Sbjct: 2077 IKSVLVVAGSLKRGDK---NRPEDQVLMRALRDFNMPKIVTDDIPVFLGLVGDLFPALDV 2133

Query: 1785 LKVNQLALEKVIYTATQQLGLQNWSSQKEKIIQFYNQLQVCVGVMLVGPTGGGKTTVRRI 1844
             +  +L  E+++  +T +L LQ   S   K++Q    L V   V +VG  G GK+ + R 
Sbjct: 2134 PRRRKLHFEQMVRQSTLELRLQPEESFILKVVQLEELLAVRHSVFVVGNAGTGKSKILRT 2193

Query: 1845 LEKALTLLPIADFLSVAERKSASKISERKGKVDICVLNPKCVTLSELYGQLDPNTMEWTD 1904
            L +                         K K     LNPK VT  EL+G +   T EW D
Sbjct: 2194 LNRTYV--------------------NMKQKPVWNDLNPKAVTTDELFGFIHHATREWKD 2233

Query: 1905 GLLSATIRSYVYFNTPKNTKKDIDLRLKSRISDLSNVFKLDSSDTTETDDNIFEEIEKVV 1964
            G +      Y YF           + L S I       K D                   
Sbjct: 2234 GKI-----VYSYF-----------IGLFSSILREQANLKHDGP----------------- 2260

Query: 1965 KIPENHNFDWQWIILDGPVDTFWVENLNSVLDDTRTLCLANSERIALTNKIRVIFEVDNL 2024
                      +WI+LDG +D  W+E+LN+V+DD + L LA++ERIALT  +R++FE+ +L
Sbjct: 2261 ----------KWIVLDGDIDPMWIESLNTVMDDNKVLTLASNERIALTPFMRLLFEIHHL 2310

Query: 2025 SQASPATVSRCAMVYMDPVDLGWEPYVKSWLLKTSKIISQSGVDCLEFMIKNSVTDGLQF 2084
              A+PATVSR  ++Y++P DLGW PYV SW+                             
Sbjct: 2311 RSATPATVSRAGILYVNPQDLGWNPYVASWI----------------------------- 2341

Query: 2085 IRNRQKFQPYPMEDITVVITLCRILDAFFDFMGKNGGFEQSDDLNDTSSKEANSQRESVT 2144
              +R++ Q    E   + I   + + A  D +              TS K   S  ES  
Sbjct: 2342 --DRRRHQ---SEKANLTILFDKYVPACLDKL-------------RTSFKTITSIPESSL 2383

Query: 2145 FKDIEKRDENTWYPEKNP-DKLTKIIQKLFVFAFTWAFGGALNREDEHRENIPFCPSLEP 2203
             + +    E    PE  P D   ++ +  FVFA  WAFGG L +                
Sbjct: 2384 VQTLCVLLECLLTPENVPSDSPKEVYEVYFVFACIWAFGGTLLQ---------------- 2427

Query: 2204 DSLAKVTYDFDKLVHELFGNSSQVGWKHWGQSQGRRRKGNCINLPTGECSIFGYFVDIEQ 2263
            D ++    DF +                W Q + +      +  P+ + +IF Y+VD + 
Sbjct: 2428 DQISDYQADFSR----------------WWQKEMK-----AVKFPS-QGTIFDYYVDHKT 2465

Query: 2264 CEFIPWSDLVPNDQTLIQRGTSLLTNLQRSGGNFLKITECGECINYTATRDTTCLSFLMS 2323
             + +PW+D +   Q  +     L T L                     T +T  L + M 
Sbjct: 2466 KKLLPWADKIA--QFTMDPDVPLQTVL-------------------VHTTETARLRYFME 2504

Query: 2324 LLLKNSCPVLLTGESGVGKTAAINQMLEKL 2353
            LLL+   P++L G +GVGKT  +   L  L
Sbjct: 2505 LLLEKGKPLMLVGNAGVGKTVFVGDTLASL 2534



 Score =  144 bits (364), Expect = 2e-33
 Identities = 87/261 (33%), Positives = 132/261 (50%), Gaps = 3/261 (1%)

Query: 2426 VVSTINFSTNVTAAKTKEMILKKLIRRTKDTLGAPKNNRILIFIDDMNMPVSDMYGAQPP 2485
            +VS + F+   T+   ++++ K L ++     G   N +++ FIDDMNMP  D+YG   P
Sbjct: 2539 IVSRVPFNYYTTSTALQKILEKPLEKKAGHNYGPGGNKKLIYFIDDMNMPEVDLYGTVQP 2598

Query: 2486 LELIRQLLDLGGVYDTEKNTWKNIQDLSIVAACVPVVND--ISPRLLKHFSMLVLPHPSQ 2543
              LIRQ +D G  YD +K   K I +   VA   P+V    I+PRL +HF++     PS 
Sbjct: 2599 HTLIRQHIDYGHWYDRQKVMLKEIHNCQYVACMNPMVGSFTINPRLQRHFTVFAFNFPSL 2658

Query: 2544 DILCTIFQAHLGIYFSINNFTPEVQKSKDQIISCSLAIYHQVRQNMLPTPTKCHYMFNLR 2603
            D L TI+      +F    F P + +S   +I  ++A +  +  N LPT  K HY+FNLR
Sbjct: 2659 DALNTIYGQIFSFHFQQQAFAPSILRSGPTLIQATIAFHQTMMCNFLPTAIKFHYIFNLR 2718

Query: 2604 DMFKLLLGLLQADRTVVNSKEMAALLFVHEATRVFHDRLIDFTDKSLFYRLLSRELENCF 2663
            D+  +  G+L A    +        L++HE+ RV+ D+LID  D  LF R +       F
Sbjct: 2719 DLSNVFQGILFASPECLKGPLDLIHLWLHESARVYGDKLIDKKDCDLFQRRMLETAYKYF 2778

Query: 2664 QIGIDGCGKKTCATLACYLTD 2684
            + GID         + C+  D
Sbjct: 2779 E-GIDSHMLLQQPLIYCHFAD 2798


>gi|239756957 PREDICTED: dynein, axonemal, heavy chain 17 [Homo
            sapiens]
          Length = 4470

 Score =  718 bits (1853), Expect = 0.0
 Identities = 505/1883 (26%), Positives = 885/1883 (46%), Gaps = 234/1883 (12%)

Query: 2653 RLLSRELENCFQIGIDGCGKKTCATLACYLTDNKLYRVPISHKCAYIEFKEVFKKVFIHA 2712
            R+L     N   +G+ G GK++ + LA Y++   ++++ +       + K      +I A
Sbjct: 2797 RILESPRGNALLVGVGGSGKQSLSRLAAYISGLDVFQITLKKGYGIPDLKIDLAAQYIKA 2856

Query: 2713 GLKGKPTVLMVPNLNIEQDSFLEDLNYIISSGRIPDLFENVELDSIAMKIRYLTEQSGHM 2772
             +K  P+V ++ +  + ++ FL  +N +++SG IP LF   E+++I   +R   +  G  
Sbjct: 2857 AVKNVPSVFLMTDSQVAEEQFLVLINDLLASGEIPGLFMEDEVENIISSMRPQVKSLGMN 2916

Query: 2773 DNRQSLLSFFQKRIYKNLHIFVIMSPEGPSFRQNCRVYPSMISSCTIDWYERWPEEALLI 2832
            D R++   FF +++ + L + +  SP G   R   R +P++++   IDW+  WPE+AL+ 
Sbjct: 2917 DTRETCWKFFIEKVRRQLKVILCFSPVGSVLRVRARKFPAVVNCTAIDWFHEWPEDALVS 2976

Query: 2833 VANSFLKEKVNFENRENLKEKLAPTCVQIHKSMKDLNRKYFEETGRFYYTTPNSYLQFME 2892
            V+  FL+E    E    +K  ++     +H ++ +++R Y     R+ YTTP ++L+ ++
Sbjct: 2977 VSARFLEET---EGIPVIKASISFFMSYVHTTVNEMSRVYLATERRYNYTTPKTFLEQIK 3033

Query: 2893 TFAHILRAREEEMQTKRDRFHMGLSTILEATTLVTEMQEELLILGPQVEQKTKETETLME 2952
             + ++L  +  E+  K +R   GL  +    + V +++ +L I   +++QK +  + L++
Sbjct: 3034 LYQNLLAKKRTELVAKIERLENGLMKLQSTASQVDDLKAKLAIQEAELKQKNESADQLIQ 3093

Query: 2953 KLRKDSQVVEKVQMLVKQDEEIVAEEVRIVEDYAQKTANELKSVLPAFDKAIVALNALDK 3012
             +  +++ V K + +  Q+E  V    + V +  +    +L    PA   A  AL+ L+K
Sbjct: 3094 VVGIEAEKVSKEKAIADQEEVKVEVINKNVTEKQKACETDLAKAEPALLAAQEALDTLNK 3153

Query: 3013 ADVAELRVYTRPPFLVLTVMNAVCIL------LQKKPNWATAKLLLSETG-FLKKLINLD 3065
             ++ EL+ +  PP  V+ V  AV IL      + K  +W  AK+++ +   FL  L   D
Sbjct: 3154 NNLTELKSFGSPPDAVVNVTAAVMILTAPGGKIPKDKSWKAAKIMMGKVDTFLDSLKKFD 3213

Query: 3066 KDSIPDKVFVKLKKIVTLPDFNPHKISLVSVACCSLCQWVIALNNYHEVQKVVGPKQIQV 3125
            K+ IP+      K     P F+P  I   S A   LC W I +  ++EV   V PK+  +
Sbjct: 3214 KEHIPEACLKAFKPYQGNPTFDPEFIRSKSTAAAGLCSWCINIVRFYEVYCDVAPKRQAL 3273

Query: 3126 AEAQNVLKIARQRLAEKQRGLQLVEEHLLFLQAAYKDTVAEKQLLANRKTMASRRFQCAS 3185
             EA   L  A+++L+  +  +  +  +L  L +A++   AEK          +R    A+
Sbjct: 3274 EEANAELAEAQEKLSRIKNKIAELNANLSNLTSAFEKATAEKIKCQQEADATNRVILLAN 3333

Query: 3186 VLLTVLEDEKTRWQETINQIDNKLEGILGDILLSAACIVYSGILTPEFRQLIVNKWETFC 3245
             L+  L  E  RW E++    ++   + GD+LL +A + Y G  T ++R  ++ K+    
Sbjct: 3334 RLVGGLASENIRWAESVENFRSQGVTLCGDVLLISAFVSYVGYFTKKYRNELMEKFWIPY 3393

Query: 3246 IEN---GISLSSKFSLIKVMAQKYEISRWHNQGLPHGQYSVENAILIKNGQQWPLLIDPH 3302
            I N    I +++    + ++    +++ W+NQGLP  + S ENA ++ N ++WPL++D  
Sbjct: 3394 IHNLKVPIPITNGLDPLSLLTDDADVATWNNQGLPSDRMSTENATILGNTERWPLIVDAQ 3453

Query: 3303 RQAHKWIRQMEGSRLQKLSIEDSNYTKKIENAMKTGGSVLLQNLLETLAPGLKAILKKDI 3362
             Q  KWI+    S L+ + +   +Y   IE A+  G ++L++N+ ET+ P L  +L ++ 
Sbjct: 3454 LQGIKWIKNKYRSELKAIRLGQKSYLDVIEQAISEGDTLLIENIGETVDPVLDPLLGRNT 3513

Query: 3363 YQKKGHYFIRVGDAEFEYNSNFRLYLSTEIDNPHFLPSVYNFVTMINFTVTFQGLQDQLL 3422
              KKG Y I++GD E EY+  FRL L T+  NPH+ P +    T+INF VT  GL+DQLL
Sbjct: 3514 I-KKGKY-IKIGDKEVEYHPKFRLILHTKYFNPHYKPEMQAQCTLINFLVTRDGLEDQLL 3571

Query: 3423 STVVTHEVPHLEDQRSKLLESISLDAITLEELEEKTLNLLQKALGSILDDDKIVDTLRKS 3482
            + VV  E P LE  ++ L +S +   I L+ELE+  L  L  A G+ L D  +V+ L  +
Sbjct: 3572 AAVVAKERPDLEQLKANLTKSQNEFKIVLKELEDSLLARLSAASGNFLGDTALVENLETT 3631

Query: 3483 KMTSNEISKRIEATKKAESEIQAIRKNYLPIATRGALLYFLVADLTQINYMYQFSLDWFH 3542
            K T++EI +++   K  E +I   R+NY P A R +LLYF++ DL +IN +YQFSL  F+
Sbjct: 3632 KHTASEIEEKVVEAKITEVKINEARENYRPAAERASLLYFILNDLNKINPVYQFSLKAFN 3691

Query: 3543 QVFVSSVVSKSKEQEHSFKREKVSPKEVHEFISISKEPNLENEKNLLDKHIKSAIDMLTK 3602
             VF  ++             ++ +P                   N + + + +  D +T 
Sbjct: 3692 VVFEKAI-------------QRTTP------------------ANEVKQRVINLTDEITY 3720

Query: 3603 SIFKVVSSALFNEDKLCFSFRLCTVIMQNNANGNLIQDDIGFLPEEEWNIFLYSGILINI 3662
            S++   +  LF  DKL F  ++   ++      N ++ D  FL                 
Sbjct: 3721 SVYMYTARGLFERDKLIFLAQVTFQVLSMKKELNPVELD--FL----------------- 3761

Query: 3663 KSALSQSRLTSTFEIGESQHLQWLSDSRWRQCQYVSTHLEPFSLLCKSLLSNVSQWDTFK 3722
                    L   F+ G    + +L    W   + +S  ++ F  L   +  +  +W    
Sbjct: 3762 --------LRFPFKAGVVSPVDFLQHQGWGGIKALS-EMDEFKNLDSDIEGSAKRWKKLV 3812

Query: 3723 NSKAVYSLISTPFSSENASLEENTKPPEETELLNENKETCNPINFPWEKLTSFQRLILVK 3782
             S+A                E+   P E                  W+  T+ Q+L +V+
Sbjct: 3813 ESEAP---------------EKEIFPKE------------------WKNKTALQKLCMVR 3839

Query: 3783 VLRPESLNNSVRKFITEKMGNKYLQRTGVNLKDAYKGSNARTPLILIQTHGIDLTNILLR 3842
             LRP+ +  +++ F+ EKMG+K+++   V    +Y+ S+  T +  I + G+D    +  
Sbjct: 3840 CLRPDRMTYAIKNFVEEKMGSKFVEGRSVEFSKSYEESSPSTSIFFILSPGVDPLKDVEA 3899

Query: 3843 FAQELKGTTHHVTI--ISLGRDQAAKAEDLILKALTKTQQWVFLQNCHLATSFMPRLCTI 3900
              ++L  T  +  +  +SLG+ Q   AE+ +  A  K   WV LQN HL   ++  L   
Sbjct: 3900 LGKKLGFTIDNGKLHNVSLGQGQEVVAENALDVAAEK-GHWVILQNIHLVARWLGTLDKK 3958

Query: 3901 VESFNSPNVTIDPEFRLWLSSKSYSS-----FPIPVLKKGLKIAVESPQGLKSNLLQTFG 3955
            +E +++ +     ++R+++S++   S      P  +L+  +KI  E P G+ +NL +   
Sbjct: 3959 LERYSTGS---HEDYRVFISAEPAPSPETHIIPQGILENAIKITNEPPTGMHANLHKALD 4015

Query: 3956 CTGSGEVTEEIFENPDCGQWWKKLLFSLCFFNAVINERKNYGILGWNIAYKFNSSDLGVA 4015
                   T++  E       +K +LF+LC+F+AV+ ER+ +G  GWN +Y FN+ DL ++
Sbjct: 4016 L-----FTQDTLEMCTKEMEFKCMLFALCYFHAVVAERRKFGAQGWNRSYPFNNGDLTIS 4070

Query: 4016 IKVLENSLRGQPSISWQALRYLIGEVIYGGRVIDNWDKRCLKTLLYKFCNPEVLKDD--- 4072
            I VL N L   P + W  LRYL GE++YGG + D+WD+R  +T L ++   E+L+ D   
Sbjct: 4071 INVLYNYLEANPKVPWDDLRYLFGEIMYGGHITDDWDRRLCRTYLAEYIRTEMLEGDVLL 4130

Query: 4073 ---FSFSRSASIKDYIHIIQSLPDDDLPEVLGIHPEAIRSCWETQGEKFIENLIAMQPKT 4129
               F    +   K Y   I      + P + G+HP A         EK    ++ MQPK 
Sbjct: 4131 APGFQIPPNLDYKGYHEYIDENLPPESPYLYGLHPNAEIGFLTVTSEKLFRTVLEMQPKE 4190

Query: 4130 TTANLMIRPEQSKDELVMEILSDLLKRLPLTVEKEEIAVGTPSTLKSMMSSSIWESLSKN 4189
            T +        S++E V  +L D+L+++P T    EI                       
Sbjct: 4191 TDSG--AGTGVSREEKVKAVLDDILEKIPETFNMAEIMA--------------------K 4228

Query: 4190 LKDHDPLIHCVLLTFLKQEIKRFDKLLFVIHKSLKDLQLAIKGEIILTQELEEIFNSFLN 4249
              +  P    V++ F  QE +R + L   + +SLK+L L +KGE+ +T ++E++  +   
Sbjct: 4229 AAEKTPY---VVVAF--QECERMNILTNEMRRSLKELNLGLKGELTITTDVEDLSTALFY 4283

Query: 4250 MRVPTLWQKHAYRSCKPLSSWIDDLIQRLNFFNTWAKVAYTAIQRRYMRFVTVWKQSIPS 4309
              VP  W   AY S   L++W  DL+ R+     W                         
Sbjct: 4284 DTVPDTWVARAYPSMMGLAAWYADLLLRIRELEAWT------------------------ 4319

Query: 4310 TSQKCKHPEDSENNFFEGFPSRYWLPAFFFPQAFLAAVLQDYGRSRGIAVDALTFTHHVI 4369
                         +F    P+  WL  FF PQ+FL A++Q   R     +D +  +  V 
Sbjct: 4320 ------------TDF--ALPTTVWLAGFFNPQSFLTAIMQSMARKNEWPLDKMCLSVEV- 4364

Query: 4370 SNTTDKDEKFSVFMPKKLNIVRRAFKGSASSHTGVYIFGLFIEGARWNREQKILEDSLPL 4429
               T K+ +     P++                G Y++GLF+EGARW+ +  ++ ++   
Sbjct: 4365 ---TKKNREDMTAPPRE----------------GSYVYGLFMEGARWDTQTGVIAEARLK 4405

Query: 4430 EMCCDFPDIYFLPTKIS-TKTPNASNQTDSELYAFECPVYQTPERSRILATTGLPTNFLT 4488
            E+    P I+     +   +T N           +ECPVY+T  R         PT ++ 
Sbjct: 4406 ELTPAMPVIFIKAIPVDRMETKN----------IYECPVYKTRIRG--------PT-YVW 4446

Query: 4489 SVYLSTKKPPSHWITMRVALLCE 4511
            +  L TK+  + WI   VALL +
Sbjct: 4447 TFNLKTKEKAAKWILAAVALLLQ 4469



 Score =  622 bits (1604), Expect = e-177
 Identities = 420/1390 (30%), Positives = 679/1390 (48%), Gaps = 223/1390 (16%)

Query: 995  DLTLRKKLWEAQEEWKRASWEWRNSSLQSIDVESVQRNVSKLMHIISVLEKGLPKSDMVT 1054
            ++ L K+LW+       +  +W+ +  + I+VE +  +  K    +  L+K +   D   
Sbjct: 1284 EVRLLKELWDMVVVVNTSIEDWKTTKWKDINVEQMDIDCKKFAKDMRSLDKEMKTWDAFV 1343

Query: 1055 HLKQVVTEFKQELPIIIALGNPCLKPRHWEALQEIIGKSVPLDKNCKVENLLALKMFQYE 1114
             L   V      L  +  L NP ++ RHW+ L +       + +   + +LL L +  YE
Sbjct: 1344 GLDNTVKNVITSLRAVSELQNPAIRERHWQQLMQATQVKFKMSEETTLADLLQLNLHSYE 1403

Query: 1115 NEINDMSTSATNEAALEKMLFKIIDFWNTTPLPLILHHTEIYSIFIIPSIDDISAQLEES 1174
            +E+ ++   A  E+ +EK+L  +   W+        H        ++ S + +   LE++
Sbjct: 1404 DEVRNIVDKAVKESGMEKVLKALDSTWSMMEFQHEPHPRT--GTMMLKSSEVLVETLEDN 1461

Query: 1175 QVILATIKGSPHIGPIKDLVNEWDQNLTLFSYTLEEWMNCQRNWLYLEPVFHSSE-IRRQ 1233
            QV L  +  S ++      V  W Q L+     +  W   QR W +LE +F  SE IR Q
Sbjct: 1462 QVQLQNLMMSKYLAHFLKEVTSWQQKLSTADSVISIWFEVQRTWSHLESIFIGSEDIRTQ 1521

Query: 1234 LPAETELFSQVISMWKKIMSKIQNKQNALQITTSAGVLEILQNCNIHLEHIKKSLEDYLE 1293
            LP +++ F  +   +K +M       N ++ T+  G+   L+     L   +K+L +YLE
Sbjct: 1522 LPGDSQRFDDINQEFKALMEDAVKTPNVVEATSKPGLYNKLEALKKSLAICEKALAEYLE 1581

Query: 1294 VKRLIFPRFYFLSNAELLDILADSRNPESVQPHLVKCFENIKQLLIWKQDIGPPAVKM-- 1351
             KRL FPRFYF+S+A+LLDIL++  +P  V  HL K F+++ +L  ++ D     +K+  
Sbjct: 1582 TKRLAFPRFYFVSSADLLDILSNGNDPVEVSRHLSKLFDSLCKLK-FRLDASDKPLKVGL 1640

Query: 1352 -LISAEGEGLVLPKKIRVRSAVEQWLVNVEKSMFDVLK--------------KERYIYNI 1396
             + S E E +V  ++  +   VE WL  V   M   L+              +E++I + 
Sbjct: 1641 GMYSKEDEYMVFDQECDLSGQVEVWLNRVLDRMCSTLRHEIPEAVVTYEEKPREQWILDY 1700

Query: 1397 ---ILLFQSQIMFYNDCVKSF----------VSSYSREKLEKVHAGLMCHLEEVADLVVL 1443
               + L  +QI +  +   +F          +  Y+++++ +++         V   +++
Sbjct: 1701 PAQVALTCTQIWWTTEVGLAFARLEEGYENAIRDYNKKQISQLN---------VLITLLM 1751

Query: 1444 DTSNSRTKAILGALLILYVHCRDIVINLLLKNIFNAEDFEWTRHLQYKWNEKQKLCYVSQ 1503
               N+  +  +  +  + VH RD+V  +++  + +++ F W   L+++W+E+++ C+ + 
Sbjct: 1752 GNLNAGDRMKIMTICTIDVHARDVVAKMIVAKVESSQAFTWQAQLRHRWDEEKRHCFANI 1811

Query: 1504 GNASFTYGYEYLGCTSRLVITPLTDRCWLTLMEALHLNLGGCPAGPAGTGKTETVKDLAK 1563
             +A   Y YEYLG T RLVITPLTDRC++TL ++LHL +GG PAGPAGTGKTET KDL +
Sbjct: 1812 CDAQIQYSYEYLGNTPRLVITPLTDRCYITLTQSLHLIMGGAPAGPAGTGKTETTKDLGR 1871

Query: 1564 SLGKHCVVFNCFEDLDYKIVRKFFFGLVQSGAWSCFDEFNLIDLEVLSVIASQILTIKAA 1623
            +LG    VFNC E +DYK     + GL Q+GAW CFDEFN I +EVLSVIA Q+  ++ A
Sbjct: 1872 ALGTMVYVFNCSEQMDYKSCGNIYKGLAQTGAWGCFDEFNRISVEVLSVIAVQVKCVQDA 1931

Query: 1624 KDNYSARFVLEGKEIRINMSCAVFITMNPRYGGGVELPDNLKSLFRPVAMMVPHYQMIAE 1683
                   F   G+ I +  +  +FITMNP Y G  ELP+NLK+LFRP AM+VP +++I E
Sbjct: 1932 IRAKKKAFNFLGEIIGLIPTVGIFITMNPGYAGRAELPENLKALFRPCAMVVPDFELICE 1991

Query: 1684 IILFSFGFKSANSLSGKLTNLYELARKQLSQQDHYNFGLRSLKIVLIMAGTKKREFKCLS 1743
            I+L + GF  A  L+ K   LY L ++ LS+QDHY++GLR++K VL++AG+ KR     +
Sbjct: 1992 IMLMAEGFLEARLLARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDPSRA 2051

Query: 1744 EADETLIVIEAIREASLPKCPPEDVPLFENIIGDIFPEVTVLKVNQLALEKVIYTATQQL 1803
            E     +++ A+R+ ++PK   +D+P+F  +IGD+FP + V +   L  EK+I  +  +L
Sbjct: 2052 EDQ---VLMRALRDFNIPKIVTDDLPVFMGLIGDLFPALDVPRKRDLNFEKIIKQSIVEL 2108

Query: 1804 GLQNWSSQKEKIIQFYNQLQVCVGVMLVGPTGGGKTTVRRILEKALTLLPIADFLSVAER 1863
             LQ   S   K++Q    LQV   V +VG  G GK+ V + L K    L         +R
Sbjct: 2109 KLQAEDSFVLKVVQLEELLQVRHSVFIVGNAGSGKSQVLKSLNKTYQNL---------KR 2159

Query: 1864 KSASKISERKGKVDICVLNPKCVTLSELYGQLDPNTMEWTDGLLSATIRSYVYFNTPKNT 1923
            K  +        VD   L+PK VT  EL+G ++P T EW DGL S  +R           
Sbjct: 2160 KPVA--------VD---LDPKAVTCDELFGIINPVTREWKDGLFSTIMR----------- 2197

Query: 1924 KKDIDLRLKSRISDLSNVFKLDSSDTTETDDNIFEEIEKVVKIPENHNFDWQWIILDGPV 1983
                         DL+N+          T D                    +WIILDG +
Sbjct: 2198 -------------DLANI----------THDGP------------------KWIILDGDI 2216

Query: 1984 DTFWVENLNSVLDDTRTLCLANSERIALTNKIRVIFEVDNLSQASPATVSRCAMVYMDPV 2043
            D  W+E+LN+V+DD + L LA++ERI L   +R++FE+ +L  A+PATVSR  ++Y++P 
Sbjct: 2217 DPMWIESLNTVMDDNKVLTLASNERIPLNRTMRLVFEISHLRTATPATVSRAGILYINPA 2276

Query: 2044 DLGWEPYVKSWLLKTSKIISQSGVDCLEFMIKNSVTDGLQFIRNRQKFQPYPMEDITVVI 2103
            DLGW P V SW+ +      ++ +  L      +  D L+F    +K  P P  +ITV+ 
Sbjct: 2277 DLGWNPVVSSWIERRKVQSEKANLMILFDKYLPTCLDKLRF--GFKKITPVP--EITVIQ 2332

Query: 2104 TLCRILDAFFDFMGKNGGFEQSDDLNDTSSKEANSQRESVTFKDIEKRDENTWYPEKNPD 2163
            T+  +L+                                +T K +             PD
Sbjct: 2333 TILYLLECL------------------------------LTEKTVP------------PD 2350

Query: 2164 KLTKIIQKLFVFAFTWAFGGALNREDEHRENIPFCPSLEPDSLAKVTYDFDKLVHELFGN 2223
               ++ +  FVF   WAFGGA+ +                D L     +F K        
Sbjct: 2351 SPRELYELYFVFTCFWAFGGAMFQ----------------DQLVDYRVEFSK-------- 2386

Query: 2224 SSQVGWKHWGQSQGRRRKGNCINLPTGECSIFGYFVDIEQCEFIPWSDLVPNDQTLIQRG 2283
                    W  ++ +      I  P+ + +IF Y++D +  +F+PW+D VP+ +  +   
Sbjct: 2387 --------WWINEFK-----TIKFPS-QGTIFDYYIDPDTKKFLPWTDKVPSFE--LDPD 2430

Query: 2284 TSLLTNLQRSGGNFLKITECGECINYTATRDTTCLSFLMSLLLKNSCPVLLTGESGVGKT 2343
              L  +L                     T +T  + + M LL++ S PV+L G +G GK+
Sbjct: 2431 VPLQASL-------------------VHTTETIRIRYFMDLLMEKSWPVMLVGNAGTGKS 2471

Query: 2344 AAINQMLEKL 2353
              +   LE L
Sbjct: 2472 VLMGDKLESL 2481



 Score =  134 bits (336), Expect = 3e-30
 Identities = 74/240 (30%), Positives = 125/240 (52%), Gaps = 2/240 (0%)

Query: 2426 VVSTINFSTNVTAAKTKEMILKKLIRRTKDTLGAPKNNRILIFIDDMNMPVSDMYGAQPP 2485
            +V  + F+   T+A  + ++ K L +++    G P   +++ FIDDMNMP  D YG   P
Sbjct: 2487 LVQAVPFNFYTTSAMLQGVLEKPLEKKSGRNYGPPGTKKLVYFIDDMNMPEVDKYGTVAP 2546

Query: 2486 LELIRQLLDLGGVYDTEKNTWKNIQDLSIVAACVPVVND--ISPRLLKHFSMLVLPHPSQ 2543
              LIRQ +D    YD  K T K+I +   VA   P      I  RL +HF +  +  P Q
Sbjct: 2547 HTLIRQHMDHRHWYDRHKLTLKDIHNCQYVACMNPTSGSFTIDSRLQRHFCVFAVSFPGQ 2606

Query: 2544 DILCTIFQAHLGIYFSINNFTPEVQKSKDQIISCSLAIYHQVRQNMLPTPTKCHYMFNLR 2603
            + L TI+   L  + +  + +  +Q+   Q+++ +LA++ ++    LPT  K HY+FNLR
Sbjct: 2607 EALTTIYNTILTQHLAFRSVSMAIQRISSQLVAAALALHQKITATFLPTAIKFHYVFNLR 2666

Query: 2604 DMFKLLLGLLQADRTVVNSKEMAALLFVHEATRVFHDRLIDFTDKSLFYRLLSRELENCF 2663
            D+  +  GLL +   V+ +      L++HE  RV+ D+++D  D+   +R+     +  F
Sbjct: 2667 DLSNIFQGLLFSTAEVLKTPLDLVRLWLHETERVYGDKMVDEKDQETLHRVTMASTKKFF 2726


>gi|239751459 PREDICTED: dynein, axonemal, heavy chain 17 [Homo
            sapiens]
          Length = 4485

 Score =  701 bits (1810), Expect = 0.0
 Identities = 506/1918 (26%), Positives = 886/1918 (46%), Gaps = 266/1918 (13%)

Query: 2653 RLLSRELENCFQIGIDGCGKKTCATLACYLTDNKLYRVPISHKCAYIEFKEVFKKVFIHA 2712
            R+L     N   +G+ G GK++ + LA Y++   ++++ +       + K      +I A
Sbjct: 2774 RILESPRGNALLVGVGGSGKQSLSRLAAYISGLDVFQITLKKGYGIPDLKIDLAAQYIKA 2833

Query: 2713 GLKGKPTVLMVPNLNIEQDSFLEDLNYIISSGRIPDLFENVELDSIAMKIRYLTEQSGHM 2772
             +K  P+V ++ +  + ++ FL  +N +++SG IP LF   E+++I   +R   +  G  
Sbjct: 2834 AVKNVPSVFLMTDSQVAEEQFLVLINDLLASGEIPGLFMEDEVENIISSMRPQVKSLGMN 2893

Query: 2773 DNRQSLLSFFQKRIYKNLHIFVIMSPEGPSFRQNCRVYPSMISSCTIDWYERWPEEALLI 2832
            D R++   FF +++ + L + +  SP G   R   R +P++++   IDW+  WPE+AL+ 
Sbjct: 2894 DTRETCWKFFIEKVRRQLKVILCFSPVGSVLRVRARKFPAVVNCTAIDWFHEWPEDALVS 2953

Query: 2833 VANSFLKEKVNFENRENLKEKLAPTCVQIHKSMKDLNRKYFEETGRFYYTTPNSYLQFME 2892
            V+  FL+E         +K  ++     +H ++ +++R Y     R+ YTTP ++L+ ++
Sbjct: 2954 VSARFLEETEGIP--WEVKASISFFMSYVHTTVNEMSRVYLATERRYNYTTPKTFLEQIK 3011

Query: 2893 TFAHILRAREEEMQTKRDRFHMGLSTILEATTLVTEMQEELLILGPQVEQKTKETETLME 2952
             + ++L  +  E+  K +R   GL  +    + V +++ +L I   +++QK +  + L++
Sbjct: 3012 LYQNLLAKKRTELVAKIERLENGLMKLQSTASQVDDLKAKLAIQEAELKQKNESADQLIQ 3071

Query: 2953 KLRKDSQVVEKVQMLVKQDEEIVAEEVRIVEDYAQKTANELKSVLPAFDKAIVALNALDK 3012
             +  +++ V K + +  Q+E  V    + V +  +    +L    PA   A  AL+ L+K
Sbjct: 3072 VVGIEAEKVSKEKAIADQEEVKVEVINKNVTEKQKACETDLAKAEPALLAAQEALDTLNK 3131

Query: 3013 ADVAELRVYTRPPFLVLTVMNAVCIL------LQKKPNWATAKLLLSETG-FLKKLINLD 3065
             ++ EL+ +  PP  V+ V  AV IL      + K  +W  AK+++ +   FL  L   D
Sbjct: 3132 NNLTELKSFGSPPDAVVNVTAAVMILTAPGGKIPKDKSWKAAKIMMGKVDTFLDSLKKFD 3191

Query: 3066 KDSIPDKVFVKLKKIVTLPDFNPHKISLVSVACCSLCQWVIALNNYHEVQKVVGPKQIQV 3125
            K+ IP+      K     P F+P  I   S A   LC W I +  ++EV   V PK+  +
Sbjct: 3192 KEHIPEACLKAFKPYQGNPTFDPEFIRSKSTAAAGLCSWCINIVRFYEVYCDVAPKRQAL 3251

Query: 3126 AEAQNVLKIARQRLAEKQRGLQLVEEHLLFLQAAYKDTVAEKQLLANRKTMASRRFQCAS 3185
             EA   L  A+++L+  +  +  +  +L  L +A++   AEK          +R    A+
Sbjct: 3252 EEANAELAEAQEKLSRIKNKIAELNANLSNLTSAFEKATAEKIKCQQEADATNRVILLAN 3311

Query: 3186 VLLTVLEDEKTRWQETINQIDNKLEGILGDILLSAACIVYSGILTPEFRQLIVNKWETFC 3245
             L+  L  E  RW E++    ++   + GD+LL +A + Y G  T ++R  ++ K+    
Sbjct: 3312 RLVGGLASENIRWAESVENFRSQGVTLCGDVLLISAFVSYVGYFTKKYRNELMEKFWIPY 3371

Query: 3246 IEN---GISLSSKFSLIKVMAQKYEISRWHNQGLPHGQYSVENAILIKNGQQWPLLIDPH 3302
            I N    I +++    + ++    +++ W+NQGLP  + S ENA ++ N ++WPL++D  
Sbjct: 3372 IHNLKVPIPITNGLDPLSLLTDDADVATWNNQGLPSDRMSTENATILGNTERWPLIVDAQ 3431

Query: 3303 RQAHKWIRQMEGSRLQKLSIEDSNYTKKIENAMKTGGSVLLQNLLETLAPGLKAILKKDI 3362
             Q  KWI+    S L+ + +   +Y   IE A+  G ++L++N+ ET+ P L  +L ++ 
Sbjct: 3432 LQGIKWIKNKYRSELKAIRLGQKSYLDVIEQAISEGDTLLIENIGETVDPVLDPLLGRNT 3491

Query: 3363 YQKKGHYFIRVGDAEFEYNSNFRLYLSTEIDNPHFLPSVYNFVTMINFTVTFQGLQDQLL 3422
              KKG Y I++GD E EY+  FRL L T+  NPH+ P +    T+INF VT  GL+DQLL
Sbjct: 3492 I-KKGKY-IKIGDKEVEYHPKFRLILHTKYFNPHYKPEMQAQCTLINFLVTRDGLEDQLL 3549

Query: 3423 STVVTHEVPHLEDQRSKLLESISLDAITLEELEEKTLNLLQKALGSILDDDKIVDTLRKS 3482
            + VV  E P LE  ++ L +S +   I L+ELE+  L  L  A G+ L D  +V+ L  +
Sbjct: 3550 AAVVAKERPDLEQLKANLTKSQNEFKIVLKELEDSLLARLSAASGNFLGDTALVENLETT 3609

Query: 3483 KMTSNEISKRIEATKKAESEIQAIRKNYLPIATRGALLYFLVADLTQINYMYQFSLDWFH 3542
            K T++EI +++   K  E +I   R+NY P A R +LLYF++ DL +IN +YQFSL  F+
Sbjct: 3610 KHTASEIEEKVVEAKITEVKINEARENYRPAAERASLLYFILNDLNKINPVYQFSLKAFN 3669

Query: 3543 QVFVSSVVSKSKEQEHSFKREKVSPKEVHEFISISKEPNLENEKNLLDKHIKSAIDMLTK 3602
             VF  ++             ++ +P                   N + + + +  D +T 
Sbjct: 3670 VVFEKAI-------------QRTTP------------------ANEVKQRVINLTDEITY 3698

Query: 3603 SIFKVVSSALFNEDKLCFSFRLCTVIMQNNANGNLIQDDIGFLPEEEWNIFLYSGILINI 3662
            S++   +  LF  DKL F  ++   ++      N ++ D  FL                 
Sbjct: 3699 SVYMYTARGLFERDKLIFLAQVTFQVLSMKKELNPVELD--FL----------------- 3739

Query: 3663 KSALSQSRLTSTFEIGESQHLQWLSDSRWRQCQYVSTHLEPFSLLCKSLLSNVSQWDTFK 3722
                    L   F+ G    + +L    W   + +S  ++ F  L   +  +  +W    
Sbjct: 3740 --------LRFPFKAGVVSPVDFLQHQGWGGIKALS-EMDEFKNLDSDIEGSAKRWKKLV 3790

Query: 3723 NSKAVYSLISTPFSSENASLEENTKPPEETELLNENKETCNPINFPWEKLTSFQRLILVK 3782
             S+A                E+   P E                  W+  T+ Q+L +V+
Sbjct: 3791 ESEAP---------------EKEIFPKE------------------WKNKTALQKLCMVR 3817

Query: 3783 VLRPESLNNSVRKFITEKMGNKYLQRTGVNLKDAYKGSNARTPLILIQTHGIDLTNILLR 3842
             LRP+ +  +++ F+ EKMG+K+++   V    +Y+ S+  T +  I + G+D    +  
Sbjct: 3818 CLRPDRMTYAIKNFVEEKMGSKFVEGRSVEFSKSYEESSPSTSIFFILSPGVDPLKDVEA 3877

Query: 3843 FAQELKGTTHHVTI--ISLGRDQAAKAEDLILKALTKTQQWVFLQ--------NCHLATS 3892
              ++L  T  +  +  +SLG+ Q   AE+ +  A  K   WV LQ        N HL   
Sbjct: 3878 LGKKLGFTIDNGKLHNVSLGQGQEVVAENALDVAAEK-GHWVILQVRGGQHCRNIHLVAR 3936

Query: 3893 FMPRLCTIVESFNSPNVTIDPEFRLWLSSKSYSS-----FPIPVLKKGLKIAVESPQGLK 3947
            ++  L   +E +++ +     ++R+++S++   S      P  +L+  +KI  E P G+ 
Sbjct: 3937 WLGTLDKKLERYSTGS---HEDYRVFISAEPAPSPETHIIPQGILENAIKITNEPPTGMH 3993

Query: 3948 SNLLQTFGCTGSGEVTEEIFENPDCGQWWKKLLFSLCFFNAVINERKNYGILGWNIAYKF 4007
            +NL +          T++  E       +K +LF+LC+F+AV+ ER+ +G  GWN +Y F
Sbjct: 3994 ANLHKALDL-----FTQDTLEMCTKEMEFKCMLFALCYFHAVVAERRKFGAQGWNRSYPF 4048

Query: 4008 NSSDLGVAIKVLENSLRGQPSISWQALRYLIGEVIYGGRVIDNWDKRCLKTLLYKFCNPE 4067
            N+ DL ++I VL N L   P + W  LRYL GE++YGG + D+WD+R  +T L ++   E
Sbjct: 4049 NNGDLTISINVLYNYLEANPKVPWDDLRYLFGEIMYGGHITDDWDRRLCRTYLAEYIRTE 4108

Query: 4068 VLKDD------FSFSRSASIKDYIHIIQSLPDDDLPEVLGIHPEAIRSCWETQGEKFIEN 4121
            +L+ D      F    +   K Y   I      + P + G+HP A         EK    
Sbjct: 4109 MLEGDVLLAPGFQIPPNLDYKGYHEYIDENLPPESPYLYGLHPNAEIGFLTVTSEKLFRT 4168

Query: 4122 LIAMQPKTT-------------TANLMIRPEQSKDE--------------LVMEILSDLL 4154
            ++ MQPK T               +L + P + K E               V  +L D+L
Sbjct: 4169 VLEMQPKETDSGAGTGVSREEKAGSLKLLPSERKGEDLELRRGGCPGTGFQVKAVLDDIL 4228

Query: 4155 KRLPLTVEKEEIAVGTPSTLKSMMSSSIWESLSKNLKDHDPLIHCVLLTFLKQEIKRFDK 4214
            +++P T    EI                         +  P    V++ F  QE +R + 
Sbjct: 4229 EKIPETFNMAEIMA--------------------KAAEKTPY---VVVAF--QECERMNI 4263

Query: 4215 LLFVIHKSLKDLQLAIKGEIILTQELEEIFNSFLNMRVPTLWQKHAYRSCKPLSSWIDDL 4274
            L   + +SLK+L L +KGE+ +T ++E++  +     VP  W   AY S   L++W  DL
Sbjct: 4264 LTNEMRRSLKELNLGLKGELTITTDVEDLSTALFYDTVPDTWVARAYPSMMGLAAWYADL 4323

Query: 4275 IQRLNFFNTWAKVAYTAIQRRYMRFVTVWKQSIPSTSQKCKHPEDSENNFFEGFPSRYWL 4334
            + R+     W                                      +F    P+  WL
Sbjct: 4324 LLRIRELEAWT------------------------------------TDF--ALPTTVWL 4345

Query: 4335 PAFFFPQAFLAAVLQDYGRSRGIAVDALTFTHHVISNTTDKDEKFSVFMPKKLNIVRRAF 4394
              FF PQ+FL A++Q   R     +D +  +  V    T K+ +     P++        
Sbjct: 4346 AGFFNPQSFLTAIMQSMARKNEWPLDKMCLSVEV----TKKNREDMTAPPRE-------- 4393

Query: 4395 KGSASSHTGVYIFGLFIEGARWNREQKILEDSLPLEMCCDFPDIYFLPTKIS-TKTPNAS 4453
                    G Y++GLF+EGARW+ +  ++ ++   E+    P I+     +   +T N  
Sbjct: 4394 --------GSYVYGLFMEGARWDTQTGVIAEARLKELTPAMPVIFIKAIPVDRMETKN-- 4443

Query: 4454 NQTDSELYAFECPVYQTPERSRILATTGLPTNFLTSVYLSTKKPPSHWITMRVALLCE 4511
                     +ECPVY+T  R         PT ++ +  L TK+  + WI   VALL +
Sbjct: 4444 --------IYECPVYKTRIRG--------PT-YVWTFNLKTKEKAAKWILAAVALLLQ 4484



 Score =  620 bits (1600), Expect = e-177
 Identities = 420/1383 (30%), Positives = 677/1383 (48%), Gaps = 219/1383 (15%)

Query: 995  DLTLRKKLWEAQEEWKRASWEWRNSSLQSIDVESVQRNVSKLMHIISVLEKGLPKSDMVT 1054
            ++ L K+LW+       +  +W+ +  + I+VE +  +  K    +  L+K +   D   
Sbjct: 1271 EVRLLKELWDMVVVVNTSIEDWKTTKWKDINVEQMDIDCKKFAKDMRSLDKEMKTWDAFV 1330

Query: 1055 HLKQVVTEFKQELPIIIALGNPCLKPRHWEALQEIIGKSVPLDKNCKVENLLALKMFQYE 1114
             L   V      L  +  L NP ++ RHW+ L +       + +   + +LL L +  YE
Sbjct: 1331 GLDNTVKNVITSLRAVSELQNPAIRERHWQQLMQATQVKFKMSEETTLADLLQLNLHSYE 1390

Query: 1115 NEINDMSTSATNEAALEKMLFKIIDFWNTTPLPLILHHTEIYSIFIIPSIDDISAQLEES 1174
            +E+ ++   A  E+ +EK+L  +   W+        H        ++ S + +   LE++
Sbjct: 1391 DEVRNIVDKAVKESGMEKVLKALDSTWSMMEFQHEPHPRT--GTMMLKSSEVLVETLEDN 1448

Query: 1175 QVILATIKGSPHIGPIKDLVNEWDQNLTLFSYTLEEWMNCQRNWLYLEPVFHSSE-IRRQ 1233
            QV L  +  S ++      V  W Q L+     +  W   QR W +LE +F  SE IR Q
Sbjct: 1449 QVQLQNLMMSKYLAHFLKEVTSWQQKLSTADSVISIWFEVQRTWSHLESIFIGSEDIRTQ 1508

Query: 1234 LPAETELFSQVISMWKKIMSKIQNKQNALQITTSAGVLEILQNCNIHLEHIKKSLEDYLE 1293
            LP +++ F  +   +K +M       N ++ T+  G+   L+     L   +K+L +YLE
Sbjct: 1509 LPGDSQRFDDINQEFKALMEDAVKTPNVVEATSKPGLYNKLEALKKSLAICEKALAEYLE 1568

Query: 1294 VKRLIFPRFYFLSNAELLDILADSRNPESVQPHLVKCFENIKQLLIWKQDIGPPAVKM-- 1351
             KRL FPRFYF+S+A+LLDIL++  +P  V  HL K F+++ +L  ++ D     +K+  
Sbjct: 1569 TKRLAFPRFYFVSSADLLDILSNGNDPVEVSRHLSKLFDSLCKLK-FRLDASDKPLKVGL 1627

Query: 1352 -LISAEGEGLVLPKKIRVRSAVEQWLVNVEKSMFDVLK----------KERYIYNIILLF 1400
             + S E E +V  ++  +   VE WL  V   M   L+          +E+     IL +
Sbjct: 1628 GMYSKEDEYMVFDQECDLSGQVEVWLNRVLDRMCSTLRHEIPEAVVTYEEKPREQWILDY 1687

Query: 1401 QSQIMFYNDCVKSF----------VSSYSREKLEKVHAGLMCHLEEVADLVVLDTSNSRT 1450
             +QI +  +   +F          +  Y+++++ +++         V   +++   N+  
Sbjct: 1688 PAQIWWTTEVGLAFARLEEGYENAIKDYNKKQISQLN---------VLITLLIGNLNAGD 1738

Query: 1451 KAILGALLILYVHCRDIVINLLLKNIFNAEDFEWTRHLQYKWNEKQKLCYVSQGNASFTY 1510
            +  +  +  + VH RD+V  +++++   ++ F W   L+++W+E+++ C+ +  +A   Y
Sbjct: 1739 RMKIMTICTIDVHARDVVAKMIVES---SQAFTWQAQLRHRWDEEKRHCFANICDAQIQY 1795

Query: 1511 GYEYLGCTSRLVITPLTDRCWLTLMEALHLNLGGCPAGPAGTGKTETVKDLAKSLGKHCV 1570
             YEYLG T RLVITPLTDRC++TL ++LHL +GG PAGPAGTGKTET KDL ++LG    
Sbjct: 1796 SYEYLGNTPRLVITPLTDRCYITLTQSLHLIMGGAPAGPAGTGKTETTKDLGRALGTMVY 1855

Query: 1571 VFNCFEDLDYKIVRKFFFGLVQSGAWSCFDEFNLIDLEVLSVIASQILTIKAAKDNYSAR 1630
            VFNC E +DYK     + GL Q+GAW CFDEFN I +EVLSVIA Q+  ++ A       
Sbjct: 1856 VFNCSEQMDYKSCGNIYKGLAQTGAWGCFDEFNRISVEVLSVIAVQVKCVQDAIRAKKKA 1915

Query: 1631 FVLEGKEIRINMSCAVFITMNPRYGGGVELPDNLKSLFRPVAMMVPHYQMIAEIILFSFG 1690
            F   G+ I +  +  +FITMNP Y G  ELP+NLK+LFRP AM+VP +++I EI+L + G
Sbjct: 1916 FNFLGEIIGLIPTVGIFITMNPGYAGRAELPENLKALFRPCAMVVPDFELICEIMLMAEG 1975

Query: 1691 FKSANSLSGKLTNLYELARKQLSQQDHYNFGLRSLKIVLIMAGTKKREFKCLSEADETLI 1750
            F  A  L+ K   LY L ++ LS+QDHY++GLR++K VL++AG+ KR     +E     +
Sbjct: 1976 FLEARLLARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDPSRAEDQ---V 2032

Query: 1751 VIEAIREASLPKCPPEDVPLFENIIGDIFPEVTVLKVNQLALEKVIYTATQQLGLQNWSS 1810
            ++ A+R+ ++PK   +D+P+F  +IGD+FP + V +   L  EK+I  +  +L LQ   S
Sbjct: 2033 LMRALRDFNIPKIVTDDLPVFMGLIGDLFPALDVPRKRDLNFEKIIKQSIVELKLQAEDS 2092

Query: 1811 QKEKIIQFYNQLQVCVGVMLVGPTGGGKTTVRRILEKALTLLPIADFLSVAERKSASKIS 1870
               K++Q    LQV   V +VG  G GK+ V + L K    L         +RK  +   
Sbjct: 2093 FVLKVVQLEELLQVRHSVFIVGNAGSGKSQVLKSLNKTYQNL---------KRKPVA--- 2140

Query: 1871 ERKGKVDICVLNPKCVTLSELYGQLDPNTMEWTDGLLSATIRSYVYFNTPKNTKKDIDLR 1930
                 VD   L+PK VT  EL+G ++P T EW DGL S  +R                  
Sbjct: 2141 -----VD---LDPKAVTCDELFGIINPVTREWKDGLFSTIMR------------------ 2174

Query: 1931 LKSRISDLSNVFKLDSSDTTETDDNIFEEIEKVVKIPENHNFDWQWIILDGPVDTFWVEN 1990
                  DL+N+          T D                    +WIILDG +D  W+E+
Sbjct: 2175 ------DLANI----------THDGP------------------KWIILDGDIDPMWIES 2200

Query: 1991 LNSVLDDTRTLCLANSERIALTNKIRVIFEVDNLSQASPATVSRCAMVYMDPVDLGWEPY 2050
            LN+V+DD + L LA++ERI L   +R++FE+ +L  A+PATVSR  ++Y++P DLGW P 
Sbjct: 2201 LNTVMDDNKVLTLASNERIPLNRTMRLVFEISHLRTATPATVSRAGILYINPADLGWNPV 2260

Query: 2051 VKSWLLKTSKIISQSGVDCLEFMIKNSVTDGLQFIRNRQKFQPYPMEDITVVITLCRILD 2110
            V SW+ +      ++ +  L      +  D L+F    +K  P P  +ITV+ T+  +L+
Sbjct: 2261 VSSWIERRKVQSEKANLMILFDKYLPTCLDKLRF--GFKKITPVP--EITVIQTILYLLE 2316

Query: 2111 AFFDFMGKNGGFEQSDDLNDTSSKEANSQRESVTFKDIEKRDENTWYPEKNPDKLTKIIQ 2170
                                            +T K +             PD   ++ +
Sbjct: 2317 CL------------------------------LTEKTVP------------PDSPRELYE 2334

Query: 2171 KLFVFAFTWAFGGALNREDEHRENIPFCPSLEPDSLAKVTYDFDKLVHELFGNSSQVGWK 2230
              FVF   WAFGGA+ +                D L     +F K               
Sbjct: 2335 LYFVFTCFWAFGGAMFQ----------------DQLVDYRVEFSK--------------- 2363

Query: 2231 HWGQSQGRRRKGNCINLPTGECSIFGYFVDIEQCEFIPWSDLVPNDQTLIQRGTSLLTNL 2290
             W  ++ +      I  P+ + +IF Y++D +  +F+PW+D VP+ +  +     L  +L
Sbjct: 2364 -WWINEFK-----TIKFPS-QGTIFDYYIDPDTKKFLPWTDKVPSFE--LDPDVPLQASL 2414

Query: 2291 QRSGGNFLKITECGECINYTATRDTTCLSFLMSLLLKNSCPVLLTGESGVGKTAAINQML 2350
                                 T +T  + + M LL++ S PV+L G +G GK+  +   L
Sbjct: 2415 -------------------VHTTETIRIRYFMDLLMEKSWPVMLVGNAGTGKSVLMGDKL 2455

Query: 2351 EKL 2353
            E L
Sbjct: 2456 ESL 2458



 Score =  134 bits (336), Expect = 3e-30
 Identities = 74/240 (30%), Positives = 125/240 (52%), Gaps = 2/240 (0%)

Query: 2426 VVSTINFSTNVTAAKTKEMILKKLIRRTKDTLGAPKNNRILIFIDDMNMPVSDMYGAQPP 2485
            +V  + F+   T+A  + ++ K L +++    G P   +++ FIDDMNMP  D YG   P
Sbjct: 2464 LVQAVPFNFYTTSAMLQGVLEKPLEKKSGRNYGPPGTKKLVYFIDDMNMPEVDKYGTVAP 2523

Query: 2486 LELIRQLLDLGGVYDTEKNTWKNIQDLSIVAACVPVVND--ISPRLLKHFSMLVLPHPSQ 2543
              LIRQ +D    YD  K T K+I +   VA   P      I  RL +HF +  +  P Q
Sbjct: 2524 HTLIRQHMDHRHWYDRHKLTLKDIHNCQYVACMNPTSGSFTIDSRLQRHFCVFAVSFPGQ 2583

Query: 2544 DILCTIFQAHLGIYFSINNFTPEVQKSKDQIISCSLAIYHQVRQNMLPTPTKCHYMFNLR 2603
            + L TI+   L  + +  + +  +Q+   Q+++ +LA++ ++    LPT  K HY+FNLR
Sbjct: 2584 EALTTIYNTILTQHLAFRSVSMAIQRISSQLVAAALALHQKITATFLPTAIKFHYVFNLR 2643

Query: 2604 DMFKLLLGLLQADRTVVNSKEMAALLFVHEATRVFHDRLIDFTDKSLFYRLLSRELENCF 2663
            D+  +  GLL +   V+ +      L++HE  RV+ D+++D  D+   +R+     +  F
Sbjct: 2644 DLSNIFQGLLFSTAEVLKTPLDLVRLWLHETERVYGDKMVDEKDQETLHRVTMASTKKFF 2703


>gi|239745966 PREDICTED: dynein, axonemal, heavy chain 17 [Homo
            sapiens]
          Length = 4485

 Score =  701 bits (1810), Expect = 0.0
 Identities = 506/1918 (26%), Positives = 886/1918 (46%), Gaps = 266/1918 (13%)

Query: 2653 RLLSRELENCFQIGIDGCGKKTCATLACYLTDNKLYRVPISHKCAYIEFKEVFKKVFIHA 2712
            R+L     N   +G+ G GK++ + LA Y++   ++++ +       + K      +I A
Sbjct: 2774 RILESPRGNALLVGVGGSGKQSLSRLAAYISGLDVFQITLKKGYGIPDLKIDLAAQYIKA 2833

Query: 2713 GLKGKPTVLMVPNLNIEQDSFLEDLNYIISSGRIPDLFENVELDSIAMKIRYLTEQSGHM 2772
             +K  P+V ++ +  + ++ FL  +N +++SG IP LF   E+++I   +R   +  G  
Sbjct: 2834 AVKNVPSVFLMTDSQVAEEQFLVLINDLLASGEIPGLFMEDEVENIISSMRPQVKSLGMN 2893

Query: 2773 DNRQSLLSFFQKRIYKNLHIFVIMSPEGPSFRQNCRVYPSMISSCTIDWYERWPEEALLI 2832
            D R++   FF +++ + L + +  SP G   R   R +P++++   IDW+  WPE+AL+ 
Sbjct: 2894 DTRETCWKFFIEKVRRQLKVILCFSPVGSVLRVRARKFPAVVNCTAIDWFHEWPEDALVS 2953

Query: 2833 VANSFLKEKVNFENRENLKEKLAPTCVQIHKSMKDLNRKYFEETGRFYYTTPNSYLQFME 2892
            V+  FL+E         +K  ++     +H ++ +++R Y     R+ YTTP ++L+ ++
Sbjct: 2954 VSARFLEETEGIP--WEVKASISFFMSYVHTTVNEMSRVYLATERRYNYTTPKTFLEQIK 3011

Query: 2893 TFAHILRAREEEMQTKRDRFHMGLSTILEATTLVTEMQEELLILGPQVEQKTKETETLME 2952
             + ++L  +  E+  K +R   GL  +    + V +++ +L I   +++QK +  + L++
Sbjct: 3012 LYQNLLAKKRTELVAKIERLENGLMKLQSTASQVDDLKAKLAIQEAELKQKNESADQLIQ 3071

Query: 2953 KLRKDSQVVEKVQMLVKQDEEIVAEEVRIVEDYAQKTANELKSVLPAFDKAIVALNALDK 3012
             +  +++ V K + +  Q+E  V    + V +  +    +L    PA   A  AL+ L+K
Sbjct: 3072 VVGIEAEKVSKEKAIADQEEVKVEVINKNVTEKQKACETDLAKAEPALLAAQEALDTLNK 3131

Query: 3013 ADVAELRVYTRPPFLVLTVMNAVCIL------LQKKPNWATAKLLLSETG-FLKKLINLD 3065
             ++ EL+ +  PP  V+ V  AV IL      + K  +W  AK+++ +   FL  L   D
Sbjct: 3132 NNLTELKSFGSPPDAVVNVTAAVMILTAPGGKIPKDKSWKAAKIMMGKVDTFLDSLKKFD 3191

Query: 3066 KDSIPDKVFVKLKKIVTLPDFNPHKISLVSVACCSLCQWVIALNNYHEVQKVVGPKQIQV 3125
            K+ IP+      K     P F+P  I   S A   LC W I +  ++EV   V PK+  +
Sbjct: 3192 KEHIPEACLKAFKPYQGNPTFDPEFIRSKSTAAAGLCSWCINIVRFYEVYCDVAPKRQAL 3251

Query: 3126 AEAQNVLKIARQRLAEKQRGLQLVEEHLLFLQAAYKDTVAEKQLLANRKTMASRRFQCAS 3185
             EA   L  A+++L+  +  +  +  +L  L +A++   AEK          +R    A+
Sbjct: 3252 EEANAELAEAQEKLSRIKNKIAELNANLSNLTSAFEKATAEKIKCQQEADATNRVILLAN 3311

Query: 3186 VLLTVLEDEKTRWQETINQIDNKLEGILGDILLSAACIVYSGILTPEFRQLIVNKWETFC 3245
             L+  L  E  RW E++    ++   + GD+LL +A + Y G  T ++R  ++ K+    
Sbjct: 3312 RLVGGLASENIRWAESVENFRSQGVTLCGDVLLISAFVSYVGYFTKKYRNELMEKFWIPY 3371

Query: 3246 IEN---GISLSSKFSLIKVMAQKYEISRWHNQGLPHGQYSVENAILIKNGQQWPLLIDPH 3302
            I N    I +++    + ++    +++ W+NQGLP  + S ENA ++ N ++WPL++D  
Sbjct: 3372 IHNLKVPIPITNGLDPLSLLTDDADVATWNNQGLPSDRMSTENATILGNTERWPLIVDAQ 3431

Query: 3303 RQAHKWIRQMEGSRLQKLSIEDSNYTKKIENAMKTGGSVLLQNLLETLAPGLKAILKKDI 3362
             Q  KWI+    S L+ + +   +Y   IE A+  G ++L++N+ ET+ P L  +L ++ 
Sbjct: 3432 LQGIKWIKNKYRSELKAIRLGQKSYLDVIEQAISEGDTLLIENIGETVDPVLDPLLGRNT 3491

Query: 3363 YQKKGHYFIRVGDAEFEYNSNFRLYLSTEIDNPHFLPSVYNFVTMINFTVTFQGLQDQLL 3422
              KKG Y I++GD E EY+  FRL L T+  NPH+ P +    T+INF VT  GL+DQLL
Sbjct: 3492 I-KKGKY-IKIGDKEVEYHPKFRLILHTKYFNPHYKPEMQAQCTLINFLVTRDGLEDQLL 3549

Query: 3423 STVVTHEVPHLEDQRSKLLESISLDAITLEELEEKTLNLLQKALGSILDDDKIVDTLRKS 3482
            + VV  E P LE  ++ L +S +   I L+ELE+  L  L  A G+ L D  +V+ L  +
Sbjct: 3550 AAVVAKERPDLEQLKANLTKSQNEFKIVLKELEDSLLARLSAASGNFLGDTALVENLETT 3609

Query: 3483 KMTSNEISKRIEATKKAESEIQAIRKNYLPIATRGALLYFLVADLTQINYMYQFSLDWFH 3542
            K T++EI +++   K  E +I   R+NY P A R +LLYF++ DL +IN +YQFSL  F+
Sbjct: 3610 KHTASEIEEKVVEAKITEVKINEARENYRPAAERASLLYFILNDLNKINPVYQFSLKAFN 3669

Query: 3543 QVFVSSVVSKSKEQEHSFKREKVSPKEVHEFISISKEPNLENEKNLLDKHIKSAIDMLTK 3602
             VF  ++             ++ +P                   N + + + +  D +T 
Sbjct: 3670 VVFEKAI-------------QRTTP------------------ANEVKQRVINLTDEITY 3698

Query: 3603 SIFKVVSSALFNEDKLCFSFRLCTVIMQNNANGNLIQDDIGFLPEEEWNIFLYSGILINI 3662
            S++   +  LF  DKL F  ++   ++      N ++ D  FL                 
Sbjct: 3699 SVYMYTARGLFERDKLIFLAQVTFQVLSMKKELNPVELD--FL----------------- 3739

Query: 3663 KSALSQSRLTSTFEIGESQHLQWLSDSRWRQCQYVSTHLEPFSLLCKSLLSNVSQWDTFK 3722
                    L   F+ G    + +L    W   + +S  ++ F  L   +  +  +W    
Sbjct: 3740 --------LRFPFKAGVVSPVDFLQHQGWGGIKALS-EMDEFKNLDSDIEGSAKRWKKLV 3790

Query: 3723 NSKAVYSLISTPFSSENASLEENTKPPEETELLNENKETCNPINFPWEKLTSFQRLILVK 3782
             S+A                E+   P E                  W+  T+ Q+L +V+
Sbjct: 3791 ESEAP---------------EKEIFPKE------------------WKNKTALQKLCMVR 3817

Query: 3783 VLRPESLNNSVRKFITEKMGNKYLQRTGVNLKDAYKGSNARTPLILIQTHGIDLTNILLR 3842
             LRP+ +  +++ F+ EKMG+K+++   V    +Y+ S+  T +  I + G+D    +  
Sbjct: 3818 CLRPDRMTYAIKNFVEEKMGSKFVEGRSVEFSKSYEESSPSTSIFFILSPGVDPLKDVEA 3877

Query: 3843 FAQELKGTTHHVTI--ISLGRDQAAKAEDLILKALTKTQQWVFLQ--------NCHLATS 3892
              ++L  T  +  +  +SLG+ Q   AE+ +  A  K   WV LQ        N HL   
Sbjct: 3878 LGKKLGFTIDNGKLHNVSLGQGQEVVAENALDVAAEK-GHWVILQVRGGQHCRNIHLVAR 3936

Query: 3893 FMPRLCTIVESFNSPNVTIDPEFRLWLSSKSYSS-----FPIPVLKKGLKIAVESPQGLK 3947
            ++  L   +E +++ +     ++R+++S++   S      P  +L+  +KI  E P G+ 
Sbjct: 3937 WLGTLDKKLEHYSTGS---HEDYRVFISAEPAPSPETHIIPQGILENAIKITNEPPTGMH 3993

Query: 3948 SNLLQTFGCTGSGEVTEEIFENPDCGQWWKKLLFSLCFFNAVINERKNYGILGWNIAYKF 4007
            +NL +          T++  E       +K +LF+LC+F+AV+ ER+ +G  GWN +Y F
Sbjct: 3994 ANLHKALDL-----FTQDTLEMCTKEMEFKCMLFALCYFHAVVAERRKFGAQGWNRSYPF 4048

Query: 4008 NSSDLGVAIKVLENSLRGQPSISWQALRYLIGEVIYGGRVIDNWDKRCLKTLLYKFCNPE 4067
            N+ DL ++I VL N L   P + W  LRYL GE++YGG + D+WD+R  +T L ++   E
Sbjct: 4049 NNGDLTISINVLYNYLEANPKVPWDDLRYLFGEIMYGGHITDDWDRRLCRTYLAEYIRTE 4108

Query: 4068 VLKDD------FSFSRSASIKDYIHIIQSLPDDDLPEVLGIHPEAIRSCWETQGEKFIEN 4121
            +L+ D      F    +   K Y   I      + P + G+HP A         EK    
Sbjct: 4109 MLEGDVLLAPGFQIPPNLDYKGYHEYIDENLPPESPYLYGLHPNAEIGFLTVTSEKLFRT 4168

Query: 4122 LIAMQPKTT-------------TANLMIRPEQSKDE--------------LVMEILSDLL 4154
            ++ MQPK T               +L + P + K E               V  +L D+L
Sbjct: 4169 VLEMQPKETDSGAGTGVSREEKAGSLKLLPSERKGEDLELRRGGCPGTGFQVKAVLDDIL 4228

Query: 4155 KRLPLTVEKEEIAVGTPSTLKSMMSSSIWESLSKNLKDHDPLIHCVLLTFLKQEIKRFDK 4214
            +++P T    EI                         +  P    V++ F  QE +R + 
Sbjct: 4229 EKIPETFNMAEIMA--------------------KAAEKTPY---VVVAF--QECERMNI 4263

Query: 4215 LLFVIHKSLKDLQLAIKGEIILTQELEEIFNSFLNMRVPTLWQKHAYRSCKPLSSWIDDL 4274
            L   + +SLK+L L +KGE+ +T ++E++  +     VP  W   AY S   L++W  DL
Sbjct: 4264 LTNEMRRSLKELNLGLKGELTITTDVEDLSTALFYDTVPDTWVARAYPSMMGLAAWYADL 4323

Query: 4275 IQRLNFFNTWAKVAYTAIQRRYMRFVTVWKQSIPSTSQKCKHPEDSENNFFEGFPSRYWL 4334
            + R+     W                                      +F    P+  WL
Sbjct: 4324 LLRIRELEAWT------------------------------------TDF--ALPTTVWL 4345

Query: 4335 PAFFFPQAFLAAVLQDYGRSRGIAVDALTFTHHVISNTTDKDEKFSVFMPKKLNIVRRAF 4394
              FF PQ+FL A++Q   R     +D +  +  V    T K+ +     P++        
Sbjct: 4346 AGFFNPQSFLTAIMQSMARKNEWPLDKMCLSVEV----TKKNREDMTAPPRE-------- 4393

Query: 4395 KGSASSHTGVYIFGLFIEGARWNREQKILEDSLPLEMCCDFPDIYFLPTKIS-TKTPNAS 4453
                    G Y++GLF+EGARW+ +  ++ ++   E+    P I+     +   +T N  
Sbjct: 4394 --------GSYVYGLFMEGARWDTQTGVIAEARLKELTPAMPVIFIKAIPVDRMETKN-- 4443

Query: 4454 NQTDSELYAFECPVYQTPERSRILATTGLPTNFLTSVYLSTKKPPSHWITMRVALLCE 4511
                     +ECPVY+T  R         PT ++ +  L TK+  + WI   VALL +
Sbjct: 4444 --------IYECPVYKTRIRG--------PT-YVWTFNLKTKEKAAKWILAAVALLLQ 4484



 Score =  620 bits (1599), Expect = e-177
 Identities = 420/1383 (30%), Positives = 677/1383 (48%), Gaps = 219/1383 (15%)

Query: 995  DLTLRKKLWEAQEEWKRASWEWRNSSLQSIDVESVQRNVSKLMHIISVLEKGLPKSDMVT 1054
            ++ L K+LW+       +  +W+ +  + I+VE +  +  K    +  L+K +   D   
Sbjct: 1271 EVRLLKELWDMVVVVNTSIEDWKTTKWKDINVEQMDIDCKKFAKDMRSLDKEMKTWDAFV 1330

Query: 1055 HLKQVVTEFKQELPIIIALGNPCLKPRHWEALQEIIGKSVPLDKNCKVENLLALKMFQYE 1114
             L   V      L  +  L NP ++ RHW+ L +       + +   + +LL L +  YE
Sbjct: 1331 GLDNTVKNVITSLRAVSELQNPAIRERHWQQLMQATQVKFKMSEETTLADLLQLNLHSYE 1390

Query: 1115 NEINDMSTSATNEAALEKMLFKIIDFWNTTPLPLILHHTEIYSIFIIPSIDDISAQLEES 1174
            +E+ ++   A  E+ +EK+L  +   W+        H        ++ S + +   LE++
Sbjct: 1391 DEVRNIVDKAVKESGMEKVLKALDSTWSMMEFQHEPHPRT--GTMMLKSSEVLVETLEDN 1448

Query: 1175 QVILATIKGSPHIGPIKDLVNEWDQNLTLFSYTLEEWMNCQRNWLYLEPVFHSSE-IRRQ 1233
            QV L  +  S ++      V  W Q L+     +  W   QR W +LE +F  SE IR Q
Sbjct: 1449 QVQLQNLMMSKYLAHFLKEVTSWQQKLSTADSVISIWFEVQRTWSHLESIFIGSEDIRTQ 1508

Query: 1234 LPAETELFSQVISMWKKIMSKIQNKQNALQITTSAGVLEILQNCNIHLEHIKKSLEDYLE 1293
            LP +++ F  +   +K +M       N ++ T+  G+   L+     L   +K+L +YLE
Sbjct: 1509 LPGDSQRFDDINQEFKALMEDAVKTPNVVEATSKPGLYNKLEALKKSLAICEKALAEYLE 1568

Query: 1294 VKRLIFPRFYFLSNAELLDILADSRNPESVQPHLVKCFENIKQLLIWKQDIGPPAVKM-- 1351
             KRL FPRFYF+S+A+LLDIL++  +P  V  HL K F+++ +L  ++ D     +K+  
Sbjct: 1569 TKRLAFPRFYFVSSADLLDILSNGNDPVEVSRHLSKLFDSLCKLK-FRLDASDKPLKVGL 1627

Query: 1352 -LISAEGEGLVLPKKIRVRSAVEQWLVNVEKSMFDVLK----------KERYIYNIILLF 1400
             + S E E +V  ++  +   VE WL  V   M   L+          +E+     IL +
Sbjct: 1628 GMYSKEDEYMVFDQECDLSGQVEVWLNRVLDRMCSTLRHEIPEAVVTYEEKPREQWILDY 1687

Query: 1401 QSQIMFYNDCVKSF----------VSSYSREKLEKVHAGLMCHLEEVADLVVLDTSNSRT 1450
             +QI +  +   +F          +  Y+++++ +++         V   +++   N+  
Sbjct: 1688 PAQIWWTTEVGLAFARLEEGYENAIRDYNKKQISQLN---------VLITLLMGNLNAGD 1738

Query: 1451 KAILGALLILYVHCRDIVINLLLKNIFNAEDFEWTRHLQYKWNEKQKLCYVSQGNASFTY 1510
            +  +  +  + VH RD+V  +++++   ++ F W   L+++W+E+++ C+ +  +A   Y
Sbjct: 1739 RMKIMTICTIDVHARDVVAKMIVES---SQAFTWQAQLRHRWDEEKRHCFANICDAQIQY 1795

Query: 1511 GYEYLGCTSRLVITPLTDRCWLTLMEALHLNLGGCPAGPAGTGKTETVKDLAKSLGKHCV 1570
             YEYLG T RLVITPLTDRC++TL ++LHL +GG PAGPAGTGKTET KDL ++LG    
Sbjct: 1796 SYEYLGNTPRLVITPLTDRCYITLTQSLHLIMGGAPAGPAGTGKTETTKDLGRALGTMVY 1855

Query: 1571 VFNCFEDLDYKIVRKFFFGLVQSGAWSCFDEFNLIDLEVLSVIASQILTIKAAKDNYSAR 1630
            VFNC E +DYK     + GL Q+GAW CFDEFN I +EVLSVIA Q+  ++ A       
Sbjct: 1856 VFNCSEQMDYKSCGNIYKGLAQTGAWGCFDEFNRISVEVLSVIAVQVKCVQDAIRAKKKA 1915

Query: 1631 FVLEGKEIRINMSCAVFITMNPRYGGGVELPDNLKSLFRPVAMMVPHYQMIAEIILFSFG 1690
            F   G+ I +  +  +FITMNP Y G  ELP+NLK+LFRP AM+VP +++I EI+L + G
Sbjct: 1916 FNFLGEIIGLIPTVGIFITMNPGYAGRAELPENLKALFRPCAMVVPDFELICEIMLMAEG 1975

Query: 1691 FKSANSLSGKLTNLYELARKQLSQQDHYNFGLRSLKIVLIMAGTKKREFKCLSEADETLI 1750
            F  A  L+ K   LY L ++ LS+QDHY++GLR++K VL++AG+ KR     +E     +
Sbjct: 1976 FLEARLLARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDPSRAEDQ---V 2032

Query: 1751 VIEAIREASLPKCPPEDVPLFENIIGDIFPEVTVLKVNQLALEKVIYTATQQLGLQNWSS 1810
            ++ A+R+ ++PK   +D+P+F  +IGD+FP + V +   L  EK+I  +  +L LQ   S
Sbjct: 2033 LMRALRDFNIPKIVTDDLPVFMGLIGDLFPALDVPRKRDLNFEKIIKQSIVELKLQAEDS 2092

Query: 1811 QKEKIIQFYNQLQVCVGVMLVGPTGGGKTTVRRILEKALTLLPIADFLSVAERKSASKIS 1870
               K++Q    LQV   V +VG  G GK+ V + L K    L         +RK  +   
Sbjct: 2093 FVLKVVQLEELLQVRHSVFIVGNAGSGKSQVLKSLNKTYQNL---------KRKPVA--- 2140

Query: 1871 ERKGKVDICVLNPKCVTLSELYGQLDPNTMEWTDGLLSATIRSYVYFNTPKNTKKDIDLR 1930
                 VD   L+PK VT  EL+G ++P T EW DGL S  +R                  
Sbjct: 2141 -----VD---LDPKAVTCDELFGIINPVTREWKDGLFSTIMR------------------ 2174

Query: 1931 LKSRISDLSNVFKLDSSDTTETDDNIFEEIEKVVKIPENHNFDWQWIILDGPVDTFWVEN 1990
                  DL+N+          T D                    +WIILDG +D  W+E+
Sbjct: 2175 ------DLANI----------THDGP------------------KWIILDGDIDPMWIES 2200

Query: 1991 LNSVLDDTRTLCLANSERIALTNKIRVIFEVDNLSQASPATVSRCAMVYMDPVDLGWEPY 2050
            LN+V+DD + L LA++ERI L   +R++FE+ +L  A+PATVSR  ++Y++P DLGW P 
Sbjct: 2201 LNTVMDDNKVLTLASNERIPLNRTMRLVFEISHLRTATPATVSRAGILYINPADLGWNPV 2260

Query: 2051 VKSWLLKTSKIISQSGVDCLEFMIKNSVTDGLQFIRNRQKFQPYPMEDITVVITLCRILD 2110
            V SW+ +      ++ +  L      +  D L+F    +K  P P  +ITV+ T+  +L+
Sbjct: 2261 VSSWIERRKVQSEKANLMILFDKYLPTCLDKLRF--GFKKITPVP--EITVIQTILYLLE 2316

Query: 2111 AFFDFMGKNGGFEQSDDLNDTSSKEANSQRESVTFKDIEKRDENTWYPEKNPDKLTKIIQ 2170
                                            +T K +             PD   ++ +
Sbjct: 2317 CL------------------------------LTEKTVP------------PDSPRELYE 2334

Query: 2171 KLFVFAFTWAFGGALNREDEHRENIPFCPSLEPDSLAKVTYDFDKLVHELFGNSSQVGWK 2230
              FVF   WAFGGA+ +                D L     +F K               
Sbjct: 2335 LYFVFTCFWAFGGAMFQ----------------DQLVDYRVEFSK--------------- 2363

Query: 2231 HWGQSQGRRRKGNCINLPTGECSIFGYFVDIEQCEFIPWSDLVPNDQTLIQRGTSLLTNL 2290
             W  ++ +      I  P+ + +IF Y++D +  +F+PW+D VP+ +  +     L  +L
Sbjct: 2364 -WWINEFK-----TIKFPS-QGTIFDYYIDPDTKKFLPWTDKVPSFE--LDPDVPLQASL 2414

Query: 2291 QRSGGNFLKITECGECINYTATRDTTCLSFLMSLLLKNSCPVLLTGESGVGKTAAINQML 2350
                                 T +T  + + M LL++ S PV+L G +G GK+  +   L
Sbjct: 2415 -------------------VHTTETIRIRYFMDLLMEKSWPVMLVGNAGTGKSVLMGDKL 2455

Query: 2351 EKL 2353
            E L
Sbjct: 2456 ESL 2458



 Score =  134 bits (336), Expect = 3e-30
 Identities = 74/240 (30%), Positives = 125/240 (52%), Gaps = 2/240 (0%)

Query: 2426 VVSTINFSTNVTAAKTKEMILKKLIRRTKDTLGAPKNNRILIFIDDMNMPVSDMYGAQPP 2485
            +V  + F+   T+A  + ++ K L +++    G P   +++ FIDDMNMP  D YG   P
Sbjct: 2464 LVQAVPFNFYTTSAMLQGVLEKPLEKKSGRNYGPPGTKKLVYFIDDMNMPEVDKYGTVAP 2523

Query: 2486 LELIRQLLDLGGVYDTEKNTWKNIQDLSIVAACVPVVND--ISPRLLKHFSMLVLPHPSQ 2543
              LIRQ +D    YD  K T K+I +   VA   P      I  RL +HF +  +  P Q
Sbjct: 2524 HTLIRQHMDHRHWYDRHKLTLKDIHNCQYVACMNPTSGSFTIDSRLQRHFCVFAVSFPGQ 2583

Query: 2544 DILCTIFQAHLGIYFSINNFTPEVQKSKDQIISCSLAIYHQVRQNMLPTPTKCHYMFNLR 2603
            + L TI+   L  + +  + +  +Q+   Q+++ +LA++ ++    LPT  K HY+FNLR
Sbjct: 2584 EALTTIYNTILTQHLAFRSVSMAIQRISSQLVAAALALHQKITATFLPTAIKFHYVFNLR 2643

Query: 2604 DMFKLLLGLLQADRTVVNSKEMAALLFVHEATRVFHDRLIDFTDKSLFYRLLSRELENCF 2663
            D+  +  GLL +   V+ +      L++HE  RV+ D+++D  D+   +R+     +  F
Sbjct: 2644 DLSNIFQGLLFSTAEVLKTPLDLVRLWLHETERVYGDKMVDEKDQETLHRVTMASTKKFF 2703


>gi|194440727 dynein heavy chain domain 2 isoform 1 [Homo sapiens]
          Length = 3092

 Score =  690 bits (1780), Expect = 0.0
 Identities = 470/1421 (33%), Positives = 690/1421 (48%), Gaps = 247/1421 (17%)

Query: 988  EISDIEGDLTLRKKLWEAQEEWKRASWEWR-------NSSLQSIDVESVQRNVSKLMHII 1040
            E+  ++ ++   +K +    +W+R+   W        N      DVE   R + K +   
Sbjct: 675  ELDKLKVNIEPYQKFFNFVLKWQRSEKRWMDGGFLDLNGESMEADVEEFSREIFKTLKFF 734

Query: 1041 SV-LEKGLPKSDMVTHLKQVVTEFKQELPIIIALGNPC-LKPRHWEALQEIIGKSVPLDK 1098
               L+K L +       + +  E  +E P   A    C ++ RHW+ + EI+G  +  D 
Sbjct: 735  QTKLKKELQEKRKAARKRSLEEEKIEEEPKDNATITMCRMRARHWKQISEIVGYDLTPDS 794

Query: 1099 NCKVENLLALKMFQYENEINDMSTSATNEAALEKMLFKIIDFWNTTPLPLILHHTEIY-- 1156
               +  +L L +  Y  +   +S  A+ E +LEK +  +I  W       I  H  +Y  
Sbjct: 795  GTTLRKVLKLNLTPYLEQFEVISAGASKEFSLEKAMNTMIGTWED-----IAFHISLYRD 849

Query: 1157 -SIFIIPSIDDISAQLEESQVILATIKGSPHIGPIKDLVNEWDQNLTLFSYTLEEWMNCQ 1215
              + I+ S+D+I A L++  +   T++GSP I P +  +  W+  L     T++EW+  Q
Sbjct: 850  TGVCILSSVDEIQAILDDQIIKTQTMRGSPFIKPFEHEIKAWEDRLIRIQETIDEWLKVQ 909

Query: 1216 RNWLYLEPVFHSSEIRRQLPAETELFSQVISMWKKIMSKIQNKQNALQITTSAGVLEILQ 1275
              WLYLEP+F S +I +Q+P E   F  V   W+ IM         L  T+  G+LE LQ
Sbjct: 910  AQWLYLEPIFCSEDIMQQMPEEGRQFQTVDRHWRDIMKFCAKDPKVLAATSLTGLLEKLQ 969

Query: 1276 NCNIHLEHIKKSLEDYLEVKRLIFPRFYFLSNAELLDILADSRNPESVQPHLVKCFENIK 1335
            NCN  LE I K L  YLE KRL FPRF+FLSN E+L+IL+++++P  VQPHL KCFE I 
Sbjct: 970  NCNELLEKIMKGLNAYLEKKRLFFPRFFFLSNDEMLEILSETKDPLRVQPHLKKCFEGIA 1029

Query: 1336 QLLIWKQDIGPPAVKMLISAEGEGLVLPKKIRV---RSAVEQWLVNVE----KSMFDVLK 1388
            +L    + +    +K + S+EGE + L   I     R AVE+WL+ VE    +S+ DV+ 
Sbjct: 1030 KL----EFLPNLDIKAMYSSEGERVELIALISTSAARGAVEKWLIQVEDLMLRSVHDVIA 1085

Query: 1389 KERYIY-------------NIILLFQSQIMFYNDCVKSFVSSYSREKLEKVHAGLMCHLE 1435
              R  Y               ++L  SQ MF+    +  +S    E L+K +  L   L 
Sbjct: 1086 AARLAYPESARRDWVREWPGQVVLCISQ-MFWTSETQEVISG-GTEGLKKYYKELQNQLN 1143

Query: 1436 EVADLVVLDTSNSRTKAILGALLILYVHCRDIVINLLLKNIFNAEDFEWTRHLQYKW-NE 1494
            E+ +LV    S  +T+  LGAL+ + VH RD+V++++   + +  DF W   L+Y W NE
Sbjct: 1144 EIVELVRGKLSK-QTRTTLGALVTIDVHARDVVMDMIKMGVSHDTDFLWLAQLRYYWENE 1202

Query: 1495 KQKLCYVSQGNASFTYGYEYLGCTSRLVITPLTDRCWLTLMEALHLNLGGCPAGPAGTGK 1554
              ++  +   N +  Y YEYLG + RLVITPLTDRC+ TL+ A +LNLGG P GPAGTGK
Sbjct: 1203 NARVRII---NCNVKYAYEYLGNSPRLVITPLTDRCYRTLIGAFYLNLGGAPEGPAGTGK 1259

Query: 1555 TETVKDLAKSLGKHCVVFNCFEDLDYKIVRKFFFGLVQSGAWSCFDEFNLIDLEVLSVIA 1614
            TET KDLAK+L   CVVFNC + LDY  + KFF GL  SGAW+CFDEFN I+LEVLSV+A
Sbjct: 1260 TETTKDLAKALAVQCVVFNCSDGLDYLAMGKFFKGLASSGAWACFDEFNRIELEVLSVVA 1319

Query: 1615 SQILTIKAAKDNYSARFVLEGKEIRINMSCAVFITMNPRYGGGVELPDNLKSLFRPVAMM 1674
             QIL I+ A       FV EG E+++N +C V ITMNP Y G  ELPDNLK LFR VAMM
Sbjct: 1320 QQILCIQRAIQQKLVVFVFEGTELKLNPNCFVAITMNPGYAGRSELPDNLKVLFRTVAMM 1379

Query: 1675 VPHYQMIAEIILFSFGFKSANSLSGKLTNLYELARKQLSQQDHYNFGLRSLKIVLIMAGT 1734
            VP+Y +IAEI L+S+GF +A  LS K+   Y L  +QLS Q HY++G+R++K VL+ AG 
Sbjct: 1380 VPNYALIAEISLYSYGFLNARPLSVKIVMTYRLCSEQLSSQFHYDYGMRAVKAVLVAAGN 1439

Query: 1735 KKREFKCLSEADETLIVIEAIREASLPKCPPEDVPLFENIIGDIFPEVTVLKVNQLALEK 1794
             K ++      +E ++++ +I++ + PK    D+PLF  I  D+FP + + + +     +
Sbjct: 1440 LKLKY---PNENEDILLLRSIKDVNEPKFLSHDIPLFNGITSDLFPGIKLPEADYHEFLE 1496

Query: 1795 VIYTATQQLGLQNWSSQKEKIIQFYNQLQVCVGVMLVGPTGGGKTTVRRILEKALTLLPI 1854
              + A     LQ      EKIIQ Y  + V  G MLVG     KT V  +L   LTL+  
Sbjct: 1497 CAHEACNVHNLQPVKFFLEKIIQTYEMMIVRHGFMLVGEPFAAKTKVLHVLADTLTLMNE 1556

Query: 1855 ADFLSVAERKSASKISERKGKVDICVLNPKCVTLSELYGQLDPNTMEWTDGLLSATIRSY 1914
              +               + KV    +NPK +T+ +L+GQ DP + EWTDG+++ T R +
Sbjct: 1557 HGY-------------GEEEKVIYRTVNPKSITMGQLFGQFDPVSHEWTDGIVANTFREF 1603

Query: 1915 VYFNTPKNTKKDIDLRLKSRISDLSNVFKLDSSDTTETDDNIFEEIEKVVKIPENHNFDW 1974
                TP                                                    D 
Sbjct: 1604 ALSETP----------------------------------------------------DR 1611

Query: 1975 QWIILDGPVDTFWVENLNSVLDDTRTLCLANSERIALTNKIRVIFEVDNLSQASPATVSR 2034
            +W++ DGP+DT W+E++N+VLDD + LCL + E I ++ ++ +IFE  +LSQASPATVSR
Sbjct: 1612 KWVVFDGPIDTLWIESMNTVLDDNKKLCLMSGEIIQMSPQMSLIFETMDLSQASPATVSR 1671

Query: 2035 CAMVYMDPVDLGWEPYVKSWLLKTSKIISQSGVDCL-----EFMIKNSVTDGLQFIRNRQ 2089
            C M+Y++P  LGWEP V SWL      + +     L      ++I  S+   ++  +   
Sbjct: 1672 CGMIYLEPSQLGWEPLVSSWLNSLKGPLCEPEYQALLRGLFAWLIPPSLNQRVELFQLNY 1731

Query: 2090 KFQPYPMEDITVVITLCRILDAFFDFMGKNGGFEQSDDLNDTSSKEANSQRESVTFKDIE 2149
             +        T+V  + +IL  F                           R S  FK + 
Sbjct: 1732 LY-------TTIVSKILKILITF---------------------------RISNYFKYVP 1757

Query: 2150 KRDENTWYPEKNPDKLTKIIQKLFVFAFTWAFGGA-----------------LNREDEHR 2192
             + + T+       K     Q  F+F+  W+ GG+                 L ++DE+ 
Sbjct: 1758 LKTQCTFI------KFFLHQQACFIFSLIWSIGGSCDTDGRRVFDTFIRLIILGKDDENP 1811

Query: 2193 ENIPFCPSLEPDSLAKVTYDFDK--LVHELFGNSSQVG-WKHWGQSQGRRRKGNCINLPT 2249
                      PDS+ K    FD+  LV++        G W H                  
Sbjct: 1812 ---------VPDSVGKWECPFDEKGLVYDYMYELKNKGRWVH------------------ 1844

Query: 2250 GECSIFGYFVDIEQCEFIPWSDLVPNDQTLIQRGTSLLTNLQRSGGNFLKITECGECINY 2309
                               W++L+ N            TNL   G   +KI +       
Sbjct: 1845 -------------------WNELIKN------------TNL---GDKQIKIQDI-----I 1865

Query: 2310 TATRDTTCLSFLMSLLLKNSCPVLLTGESGVGKTAAINQML 2350
              T DT   +FLM L +  + P+L  G +G GK+  +   L
Sbjct: 1866 VPTMDTIRYTFLMDLSITYAKPLLFVGPTGTGKSVYVKDKL 1906



 Score =  409 bits (1050), Expect = e-113
 Identities = 290/947 (30%), Positives = 449/947 (47%), Gaps = 177/947 (18%)

Query: 3582 LENEKNLLDKHIKSAIDMLTKSIFKVVSSALFNEDKLCFSFRLCTVIMQNNANGNLIQDD 3641
            ++N+  +L+K ++   D  T +++  +  +LF +DKL FSF LC       AN  L + +
Sbjct: 2309 VDNKSKILEKRLRYLNDHFTYNLYCNICRSLFEKDKLLFSFLLC-------ANLLLARKE 2361

Query: 3642 IGFLPEEEWNIFLYSGILINIKSALSQSRLTSTFEIGESQHLQWLSDSRWRQ-CQYVSTH 3700
            I +   +E    L  G+  ++KSA      T            WL D  W + C+  ++ 
Sbjct: 2362 IEY---QELMFLLTGGV--SLKSAEKNPDPT------------WLQDKSWEEICR--ASE 2402

Query: 3701 LEPFSLLCKSLLSNVSQWDTFKNSKAVYSLISTPFSSENASLEENTKPPEETELLNENKE 3760
               F  L +    ++ +W    +SK  +                N K P   +       
Sbjct: 2403 FPAFRGLRQHFCEHIYEWREIYDSKEPH----------------NAKFPAPMD------- 2439

Query: 3761 TCNPINFPWEKLTSFQRLILVKVLRPESLNNSVRKFITEKMGNKYLQRTGVNLKDAYKGS 3820
                     + L   Q++I+++ LRP+ +  ++  ++T+K+G K+++    +L  +Y  S
Sbjct: 2440 ---------KNLNELQKIIILRCLRPDKITPAITNYVTDKLGKKFVEPPPFDLTKSYLDS 2490

Query: 3821 NARTPLILIQTHGIDLTNILLRFAQELKGTTHHVTIISLGRDQAAKAEDLILKALTKTQQ 3880
            N   PLI + + G D    LL+FA +   + +    ISLG+ Q   A  +I KA  +   
Sbjct: 2491 NCTIPLIFVLSPGADPMASLLKFANDKSMSGNKFQAISLGQGQGPIAAKMI-KAAIEEGT 2549

Query: 3881 WVFLQNCHLATSFMPRLCTIVESFNSPNVTIDPEFRLWLSSKSYSSFPIPVLKKGLKIAV 3940
            WV LQNCHLA S+MP L  I E F S   T +  FRLWL+S   S FP+ +L+ G+K+  
Sbjct: 2550 WVCLQNCHLAVSWMPMLEKICEDFTSE--TCNSSFRLWLTSYPSSKFPVTILQNGVKMTN 2607

Query: 3941 ESPQGLKSNLLQTFGCTGSGEVTEEIFENPDCGQW--WKKLLFSLCFFNAVINERKNYGI 3998
            E P GL+ NLLQ++    +  V++  F     G+   W+KLLF +CFF+A++ ERK +G 
Sbjct: 2608 EPPTGLRLNLLQSYL---TDPVSDPEFFKGCRGKELAWEKLLFGVCFFHALVQERKKFGP 2664

Query: 3999 LGWNIAYKFNSSDLGVAIKVLENSLRGQPSISWQALRYLIGEVIYGGRVIDNWDKRCLKT 4058
            LGWNI Y FN SDL ++I+ L+  +    +I ++A+ YL GE  YGGRV D+WD+R L T
Sbjct: 2665 LGWNIPYGFNESDLRISIRQLQLFINEYDTIPFEAISYLTGECNYGGRVTDDWDRRLLLT 2724

Query: 4059 LLYKFCNPEVLKD-DFSFSRS--------ASIKDYIHIIQSLPDDDLPEVLGIHPEAIRS 4109
            +L  F N  ++++  + FS S         + +DYI  I+ LP    PE+ G+H     S
Sbjct: 2725 MLADFYNLYIVENPHYKFSPSGNYFAPPKGTYEDYIEFIKKLPFTQHPEIFGLHENVDIS 2784

Query: 4110 CWETQGEKFIENLIAMQ--PKTTTANLMIRPEQSKDELVMEILSDLLKRLPLTVEKEEIA 4167
                Q +   E+L+  Q   K T A+       S D++++EI  D+L +LP   + E   
Sbjct: 2785 KDLQQTKTLFESLLLTQGGSKQTGAS------GSTDQILLEITKDILNKLPSDFDIEMAL 2838

Query: 4168 VGTPSTLKSMMSSSIWESLSKNLKDHDPLIHCVLLTFLKQEIKRFDKLLFVIHKSLKDLQ 4227
               P   +  M+                       T L QE++RF+ L+  I  +L+DL+
Sbjct: 2839 RKYPVRYEESMN-----------------------TVLVQEMERFNNLIITIRNTLRDLE 2875

Query: 4228 LAIKGEIILTQELEEIFNSFLNMRVPTLWQKHAYRSCKPLSSWIDDLIQRLNFFNTWAKV 4287
             AIKG +++   LE +  S L  +VP +W K +Y S KPL S+I D + RLNF   W   
Sbjct: 2876 KAIKGVVVMDSALEALSGSLLVGKVPEIWAKRSYPSLKPLGSYITDFLARLNFLQDW--- 2932

Query: 4288 AYTAIQRRYMRFVTVWKQSIPSTSQKCKHPEDSENNFFEGFPSRYWLPAFFFPQAFLAAV 4347
                                                +  G P  +WL  FFF QAFL   
Sbjct: 2933 ------------------------------------YNSGKPCVFWLSGFFFTQAFLTGA 2956

Query: 4348 LQDYGRSRGIAVDALTFTHHVISNTTDKDEKFSVFMPKKLNIVRRAFKGSASSHTGVYIF 4407
            +Q+Y R     +D L +   VI + T                         S   GVYI 
Sbjct: 2957 MQNYARKYTTPIDLLGYEFEVIPSDT----------------------SDTSPEDGVYIH 2994

Query: 4408 GLFIEGARWNREQKILEDSLPLEMCCDFPDIYFLPTKISTKTPNASNQTDSELYAFECPV 4467
            GL+++GARW+RE  +L +  P  +    P I+  PT+ S    +          A+ CP+
Sbjct: 2995 GLYLDGARWDRESGLLAEQYPKLLFDLMPIIWIKPTQKSRIIKSD---------AYVCPL 3045

Query: 4468 YQTPERSRILATTGLPTNFLTSVYLSTKKPPSHWITMRVALLCEKNE 4514
            Y+T ER   L+TTG  TNF+ ++ L T +P  HWI   VALLC+ ++
Sbjct: 3046 YKTSERKGTLSTTGHSTNFVIAMLLKTDQPTRHWIKRGVALLCQLDD 3092



 Score =  172 bits (435), Expect = 9e-42
 Identities = 95/272 (34%), Positives = 149/272 (54%), Gaps = 11/272 (4%)

Query: 2396 TATGSSDNPTKKPEVRTNKKLLKNNDHKGVVVSTINFSTNVTAAKTKEMILKKLIRRTKD 2455
            T TG S        V    KL+ + +        IN S   +A + + +I+ +L +R K 
Sbjct: 1894 TGTGKS--------VYVKDKLMNHLEKDQYFPFYINLSARTSANQVQNIIMARLDKRRKG 1945

Query: 2456 TLGAPKNNRILIFIDDMNMPVSDMYGAQPPLELIRQLLDLGGVYDTEKNTWKNIQDLSIV 2515
              G P   + +IFIDDMNMP  + YGAQPP+EL+RQ  D G  YD +  +   + D+ ++
Sbjct: 1946 VFGPPMGKKCIIFIDDMNMPALEKYGAQPPIELLRQFFDCGHWYDLKDTSKITLVDIELI 2005

Query: 2516 AACVPVV---NDISPRLLKHFSMLVLPHPSQDILCTIFQAHLGIYFSINNFTPEVQKSKD 2572
            AA  P     N ++PR ++HF++  +   S + +  IF + +  Y   + F PE     +
Sbjct: 2006 AAMGPPGGGRNPVTPRCIRHFNICSINSFSDETMVRIFSSIVAFYLRTHEFPPEYFVIGN 2065

Query: 2573 QIISCSLAIYHQVRQNMLPTPTKCHYMFNLRDMFKLLLGLLQADRTVVNSKEMAALLFVH 2632
            QI++ ++ IY Q  +N+LPTPTK HY FNLRD  +++ G L  +R  V +K     LFVH
Sbjct: 2066 QIVNGTMEIYKQSVENLLPTPTKSHYTFNLRDFSRVIRGCLLIERDAVANKHTMIRLFVH 2125

Query: 2633 EATRVFHDRLIDFTDKSLFYRLLSRELENCFQ 2664
            E  RVF+DRLI+  D+   ++L    +++ F+
Sbjct: 2126 EVLRVFYDRLINDDDRRWLFQLTKTVIKDHFK 2157


>gi|33350932 cytoplasmic dynein 1 heavy chain 1 [Homo sapiens]
          Length = 4646

 Score =  539 bits (1389), Expect = e-152
 Identities = 398/1664 (23%), Positives = 754/1664 (45%), Gaps = 163/1664 (9%)

Query: 2665 IGIDGCGKKTCATLACYLTDNKLYRVPISHKCAYIEFKEVFKKVFIHAGLKGKPTVLMVP 2724
            IG+ G GK T +    ++    +Y++ +  K    +F E  + V   +G K +    ++ 
Sbjct: 2936 IGVSGAGKTTLSRFVAWMNGLSVYQIKVHRKYTGEDFDEDLRTVLRRSGCKNEKIAFIMD 2995

Query: 2725 NLNIEQDSFLEDLNYIISSGRIPDLFENVELDSIAMKIRYLTEQSGHM-DNRQSLLSFFQ 2783
              N+    FLE +N ++++G +P LFE  E  ++  + +   ++ G M D+ + L  +F 
Sbjct: 2996 ESNVLDSGFLERMNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLMLDSHEELYKWFT 3055

Query: 2784 KRIYKNLHIFVIMSPEGPSFRQNCRVYPSMISSCTIDWYERWPEEALLIVANSFLK---- 2839
             ++ +NLH+   M+P     +      P++ + C ++W+  W  EAL  V   F      
Sbjct: 3056 SQVIRNLHVVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDWSTEALYQVGKEFTSKMDL 3115

Query: 2840 EKVNFENRENL-------------KEKLAPTCVQIHKSMKDLNRKYFEETGRFYYTTPNS 2886
            EK N+   + +             +E +  +CV +H+++   N +  +  GR    TP  
Sbjct: 3116 EKPNYIVPDYMPVVYDKLPQPPSHREAIVNSCVFVHQTLHQANARLAKRGGRTMAITPRH 3175

Query: 2887 YLQFMETFAHILRAREEEMQTKRDRFHMGLSTILEATTLVTEMQEELLILGPQVEQKTKE 2946
            YL F+  +A++   +  E++ ++   ++GL  I E    V E++ +L I   ++E K   
Sbjct: 3176 YLDFINHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAA 3235

Query: 2947 TETLMEKLRKDSQVVEKVQMLVKQDEEIVAEEVRIVEDYAQKTANELKSVLPAFDKAIVA 3006
                ++K+ KD Q  EK +++ ++ +E + ++  ++ D       +L  V PA  +A  A
Sbjct: 3236 ANDKLKKMVKDQQEAEKKKVMSQEIQEQLHKQQEVIADKQMSVKEDLDKVEPAVIEAQNA 3295

Query: 3007 LNALDKADVAELRVYTRPPFLVLTVMNAVCILL-QKKPNWATAKLLLSETGFLKKLINLD 3065
            + ++ K  + E+R    PP  V   + ++C+LL +   +W   + ++    F+  ++N  
Sbjct: 3296 VKSIKKQHLVEVRSMANPPAAVKLALESICLLLGESTTDWKQIRSIIMRENFIPTIVNFS 3355

Query: 3066 KDSIPDKVFVKLKK-IVTLPDFNPHKISLVSVACCSLCQWVIALNNYHEVQKVVGPKQIQ 3124
             + I D +  K+KK  ++ P +N   ++  S+AC  + +W IA  NY ++ K V P + +
Sbjct: 3356 AEEISDAIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYADMLKRVEPLRNE 3415

Query: 3125 VAEAQNVLKIARQRLAEKQRGLQLVEEHLLFLQAAYKDTVAEKQLLANRKTMASRRFQCA 3184
            + + ++  K  +Q+  E ++ ++ +E  +   +  Y   ++E Q +         +   +
Sbjct: 3416 LQKLEDDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRS 3475

Query: 3185 SVLLTVLEDEKTRWQETINQIDNKLEGILGDILLSAACIVYSGILTPEFRQLIVNKWETF 3244
            + LL  L  E+ RW++T     N++  I GD LLSAA I Y+G    + RQ +   W   
Sbjct: 3476 TALLKSLSAERERWEKTSETFKNQMSTIAGDCLLSAAFIAYAGYFDQQMRQNLFTTWSHH 3535

Query: 3245 CIENGISLSSKFSLIKVMAQKYEISRWHNQGLPHGQYSVENAILIKNGQQWPLLIDPHRQ 3304
              +  I   +  +  + ++   E  RW    LP      ENAI++K   ++PL+IDP  Q
Sbjct: 3536 LQQANIQFRTDIARTEYLSNADERLRWQASSLPADDLCTENAIMLKRFNRYPLIIDPSGQ 3595

Query: 3305 AHKWI-RQMEGSRLQKLSIEDSNYTKKIENAMKTGGSVLLQNLLETLAPGLKAILKKDIY 3363
            A ++I  + +  ++ + S  D  + K +E+A++ G  +L+Q++ E+  P L  +L +++ 
Sbjct: 3596 ATEFIMNEYKDRKITRTSFLDDAFRKNLESALRFGNPLLVQDV-ESYDPVLNPVLNREVR 3654

Query: 3364 QKKGHYFIRVGDAEFEYNSNFRLYLSTEIDNPHFLPSVYNFVTMINFTVTFQGLQDQLLS 3423
            +  G   I +GD + + + +F ++LST      F P + + VT +NFTVT   LQ Q L+
Sbjct: 3655 RTGGRVLITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLCSRVTFVNFTVTRSSLQSQCLN 3714

Query: 3424 TVVTHEVPHLEDQRSKLLESISLDAITLEELEEKTLNLLQKALGSILDDDKIVDTLRKSK 3483
             V+  E P ++++RS LL+      + L +LE+  L  L +  G ILDDD I+ TL   K
Sbjct: 3715 EVLKAERPDVDEKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKGRILDDDTIITTLENLK 3774

Query: 3484 MTSNEISKRIEATKKAESEIQAIRKNYLPIATRGALLYFLVADLTQINYMYQFSLDWFHQ 3543
              + E+++++E T     E++ + + YLP++T  + +YF +  L QI+++YQ+SL +F  
Sbjct: 3775 REAAEVTRKVEETDIVMQEVETVSQQYLPLSTACSSIYFTMESLKQIHFLYQYSLQFFLD 3834

Query: 3544 VFVSSVVSKSKEQEHSFKREKVSPKEVHEFISISKEPNLENEKNLLDKHIKSAIDMLTKS 3603
            ++            H+                + + PNL   K + D      + ++TK 
Sbjct: 3835 IY------------HNV---------------LYENPNL---KGVTDH--TQRLSIITKD 3862

Query: 3604 IFKV----VSSALFNEDKLCFSFRLCTVIMQNNANGNLIQDDIGFLPEEEWNIFLYSGIL 3659
            +F+V    V+  + ++D + F+  L  + ++                + E+  FL    +
Sbjct: 3863 LFQVAFNRVARGMLHQDHITFAMLLARIKLKGTVGEPTY--------DAEFQHFLRGNEI 3914

Query: 3660 INIKSALSQSRLTSTFEIGESQHLQWLSDSRWRQCQYVSTHLEPFSLLCKSLLSNVSQWD 3719
            +                 G +  +Q L+  +                     +  +S   
Sbjct: 3915 V--------------LSAGSTPRIQGLTVEQ------------------AEAVVRLSCLP 3942

Query: 3720 TFKNSKAVYSLISTPFSSENASLEENTKPPEETELLNENKET-CNPINFPWEKLTSFQRL 3778
             FK+      LI+   + E   +  ++  PE+T     ++ET   PI        +  RL
Sbjct: 3943 AFKD------LIAKVQADEQFGIWLDSSSPEQTVPYLWSEETPATPIG------QAIHRL 3990

Query: 3779 ILVKVLRPESLNNSVRKFITEKMGNKYLQRTGVNLKDAY-KGSNAR--TPLILIQTHGID 3835
            +L++  RP+ L      F++  +G  ++      L   +  G+  +  TP+++    G D
Sbjct: 3991 LLIQAFRPDRLLAMAHMFVSTNLGESFMSIMEQPLDLTHIVGTEVKPNTPVLMCSVPGYD 4050

Query: 3836 LTNILLRFAQELKGTTHHVTIISLGRDQAAKAEDLILKALTKTQQWVFLQNCHLATSFMP 3895
             +  +   A E       +T I++G  +     D  +    K+ +WV L+N HLA  ++ 
Sbjct: 4051 ASGHVEDLAAE---QNTQITSIAIGSAEGFNQADKAINTAVKSGRWVMLKNVHLAPGWLM 4107

Query: 3896 RLCTIVESFNSPNVTIDPEFRLWLSSKSYSSFPIPVLKKGLKIAVESPQGLKSNLLQTFG 3955
            +L   + S   P+      FRL+L+ +     P+ +L+ G     E P G+K+N+L+TF 
Sbjct: 4108 QLEKKLHSL-QPHAC----FRLFLTMEINPKVPVNLLRAGRIFVFEPPPGVKANMLRTFS 4162

Query: 3956 CTGSGEVTEEIFENPDCGQWWKKLLFSLCFFNAVINERKNYGILGWNIAYKFNSSDLGVA 4015
                  + +   E         +L F L +F+A+I ER  Y  LGW+  Y+F  SDL  A
Sbjct: 4163 SIPVSRICKSPNER-------ARLYFLLAWFHAIIQERLRYAPLGWSKKYEFGESDLRSA 4215

Query: 4016 IKV----LENSLRGQPSIS-----WQALRYLIGEVIYGGRVIDNWDKRCLKTLLYKFCNP 4066
                   L+++ +G+ +IS     W AL+ L+ + IYGGRV + +D+R L T L +    
Sbjct: 4216 CDTVDTWLDDTAKGRQNISPDKIPWSALKTLMAQSIYGGRVDNEFDQRLLNTFLERLFTT 4275

Query: 4067 EVLKDDFSFSRSAS------------IKDYIHIIQSLPDDDLPEVLGIHPEAIRSCWETQ 4114
                 +F  +                 ++++  ++ LPD   P  LG+   A R    TQ
Sbjct: 4276 RSFDSEFKLACKVDGHKDIQMPDGIRREEFVQWVELLPDTQTPSWLGLPNNAERVLLTTQ 4335

Query: 4115 GEKFIENLIAMQPKTTTANLMIRPEQSKDELVMEILSDLLKRLPLTVEKEEIAVGTPSTL 4174
            G   I  ++ MQ      +L     + K             R   T +     + T  T 
Sbjct: 4336 GVDMISKMLKMQMLEDEDDLAYAETEKK------------TRTDSTSDGRPAWMRTLHTT 4383

Query: 4175 KSMMSSSIWESLSKNLKDHDPLIHCVLLTFLKQEIKRFDKLLFVIHKSLKDLQLAIKGEI 4234
             S     I ++LS +LK     I   L  F ++E+K   KLL  + + L D+    +G+ 
Sbjct: 4384 ASNWLHLIPQTLS-HLKRTVENIKDPLFRFFEREVKMGAKLLQDVRQDLADVVQVCEGKK 4442

Query: 4235 ILTQELEEIFNSFLNMRVPTLWQKHAYRSCKPLSSWIDDLIQRL 4278
              T  L  + N  +   +P  W  +   +   +  W+ D  +R+
Sbjct: 4443 KQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERI 4486



 Score =  536 bits (1381), Expect = e-151
 Identities = 358/1160 (30%), Positives = 579/1160 (49%), Gaps = 153/1160 (13%)

Query: 979  EEITQIVLSEISDIEGDLTLRKKLWEAQEEWKRASWEWRNSSLQSIDVESVQRNVSKLMH 1038
            EE  Q+ L E+ D++G  +   K+WE  ++ K   W        S+    +++N+  L++
Sbjct: 1316 EERVQVALEELQDLKGVWSELSKVWEQIDQMKEQPWV-------SVQPRKLRQNLDALLN 1368

Query: 1039 IISVLEKGLPKSDMVTHLKQVVTEFKQELPIIIALGNPCLKPRHWEALQEIIGKSVPLDK 1098
             +      L +      +++++  + +   ++I L +  LK RHW+ L + +  +  + +
Sbjct: 1369 QLKSFPARLRQYASYEFVQRLLKGYMKINMLVIELKSEALKDRHWKQLMKRLHVNWVVSE 1428

Query: 1099 NCKVENLLALKMFQYENEINDMSTSATNEAALEKMLFKIIDFWNTTPLPLILHHTEIYSI 1158
               +  +  + + + E  + D+   A  E ALE+ L +I + WNT  L L+ +  +    
Sbjct: 1429 -LTLGQIWDVDLQKNEAIVKDVLLVAQGEMALEEFLKQIREVWNTYELDLVNYQNKCR-- 1485

Query: 1159 FIIPSIDDISAQLEESQVILATIKGSPHIGPIKDLVNEWDQNLTLFSYTLEEWMNCQRNW 1218
             +I   DD+  +++E    ++ +K SP+    ++    W+  L       + W++ QR W
Sbjct: 1486 -LIRGWDDLFNKVKEHINSVSAMKLSPYYKVFEEDALSWEDKLNRIMALFDVWIDVQRRW 1544

Query: 1219 LYLEPVFH-SSEIRRQLPAETELFSQVISMWKKIMSKIQNKQNALQITTSAGVLEILQNC 1277
            +YLE +F  S++I+  LP ET+ F  + + +  +M K+      + +    GV   L+  
Sbjct: 1545 VYLEGIFTGSADIKHLLPVETQRFQSISTEFLALMKKVSKSPLVMDVLNIQGVQRSLERL 1604

Query: 1278 NIHLEHIKKSLEDYLEVKRLIFPRFYFLSNAELLDILADSRNPESVQPHLVKCFENIKQL 1337
               L  I+K+L +YLE +R  FPRFYF+ + +LL+I+ +S+N   +Q H  K F  +  +
Sbjct: 1605 ADLLGKIQKALGEYLERERSSFPRFYFVGDEDLLEIIGNSKNVAKLQKHFKKMFAGVSSI 1664

Query: 1338 LIWKQDIGPPAVKMLISAEGEGLVL--PKKIRVRSAVEQWLVNVEKSMFDVLKK------ 1389
            ++ + +     V  + S EGE ++   P  I     + +WL  VEK M   L K      
Sbjct: 1665 ILNEDN---SVVLGISSREGEEVMFKTPVSITEHPKINEWLTLVEKEMRVTLAKLLAESV 1721

Query: 1390 --------------ERYI-----YNIILLFQSQIMFYNDCVKSFVSSYS----REKLEKV 1426
                            YI     Y   L+  S  + +++ V++ +SS         L  V
Sbjct: 1722 TEVEIFGKATSIDPNTYITWIDKYQAQLVVLSAQIAWSENVETALSSMGGGGDAAPLHSV 1781

Query: 1427 HAGLMCHLEEVADLVVLDTSNSRTKAILGALLILYVHCRDIVINLLLKNIFNAEDFEWTR 1486
             + +   L  +AD V+++    R +  L  L+   VH RD+  +L+   I NA+ FEW  
Sbjct: 1782 LSNVEVTLNVLADSVLMEQPPLRRRK-LEHLITELVHQRDVTRSLIKSKIDNAKSFEWLS 1840

Query: 1487 HLQYKWNEKQ----KLCYVSQGNASFTYGYEYLGCTSRLVITPLTDRCWLTLMEALHLNL 1542
             +++ ++ KQ    +   +   NA F YG+EYLG   +LV TPLTDRC+LT+ +AL   L
Sbjct: 1841 QMRFYFDPKQTDVLQQLSIQMANAKFNYGFEYLGVQDKLVQTPLTDRCYLTMTQALEARL 1900

Query: 1543 GGCPAGPAGTGKTETVKDLAKSLGKHCVVFNCFEDLDYKIVRKFFFGLVQSGAWSCFDEF 1602
            GG P GPAGTGKTE+VK L   LG+  +VFNC E  D++ + + F GL Q GAW CFDEF
Sbjct: 1901 GGSPFGPAGTGKTESVKALGHQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEF 1960

Query: 1603 NLIDLEVLSVIASQILTIKAA--------KDNYSARFVLE--GKEIRINMSCAVFITMNP 1652
            N ++  +LS ++ Q+  I+ A         D  SA    E   K+++++   A+FITMNP
Sbjct: 1961 NRLEERMLSAVSQQVQCIQEALREHSNPNYDKTSAPITCELLNKQVKVSPDMAIFITMNP 2020

Query: 1653 RYGGGVELPDNLKSLFRPVAMMVPHYQMIAEIILFSFGFKSANSLSGKLTNLYELARKQL 1712
             Y G   LPDNLK LFR +AM  P  Q+IA+++L+S GF++A  L+ K+   ++L  +QL
Sbjct: 2021 GYAGRSNLPDNLKKLFRSLAMTKPDRQLIAQVMLYSQGFRTAEVLANKIVPFFKLCDEQL 2080

Query: 1713 SQQDHYNFGLRSLKIVLIMAGTKKRE------------FKCLSEAD------ETLIVIEA 1754
            S Q HY+FGLR+LK VL+ AG  KRE             + + E +      E  I+I++
Sbjct: 2081 SSQSHYDFGLRALKSVLVSAGNVKRERIQKIKREKEERGEAVDEGEIAENLPEQEILIQS 2140

Query: 1755 IREASLPKCPPEDVPLFENIIGDIFPEVTVLKVNQLALEKVIYTATQQLGLQNWSSQK-- 1812
            + E  +PK   ED+PL  +++ D+FP V   +    AL + +    Q++ L     ++  
Sbjct: 2141 VCETMVPKLVAEDIPLLFSLLSDVFPGVQYHRGEMTALREELKKVCQEMYLTYGDGEEVG 2200

Query: 1813 ----EKIIQFYNQLQVCVGVMLVGPTGGGKTTVRRILEKALTLLPIADFLSVAERKSASK 1868
                EK++Q Y   Q+  G+M+VGP+G GK+   R+L KAL  L   +   VA       
Sbjct: 2201 GMWVEKVLQLYQITQINHGLMMVGPSGSGKSMAWRVLLKALERLEGVE--GVAH------ 2252

Query: 1869 ISERKGKVDICVLNPKCVTLSELYGQLDPNTMEWTDGLLSATIRSYVYFNTPKNTKKDID 1928
                       +++PK ++   LYG LDPNT EWTDGL +  +R  +             
Sbjct: 2253 -----------IIDPKAISKDHLYGTLDPNTREWTDGLFTHVLRKII------------- 2288

Query: 1929 LRLKSRISDLSNVFKLDSSDTTETDDNIFEEIEKVVKIPENHNFDWQWIILDGPVDTFWV 1988
                                     D++  E++K            QWI+ DG VD  WV
Sbjct: 2289 -------------------------DSVRGELQK-----------RQWIVFDGDVDPEWV 2312

Query: 1989 ENLNSVLDDTRTLCLANSERIALTNKIRVIFEVDNLSQASPATVSRCAMVYMDPVDLGWE 2048
            ENLNSVLDD + L L N ER++L   +R++FEV +L  A+ ATVSRC MV+     L  +
Sbjct: 2313 ENLNSVLDDNKLLTLPNGERLSLPPNVRIMFEVQDLKYATLATVSRCGMVWFSEDVLSTD 2372

Query: 2049 PYVKSWLLKTSKIISQSGVD 2068
                ++L +   I    G D
Sbjct: 2373 MIFNNFLARLRSIPLDEGED 2392



 Score = 85.9 bits (211), Expect = 8e-16
 Identities = 60/227 (26%), Positives = 114/227 (50%), Gaps = 25/227 (11%)

Query: 2435 NVTAAKTKEMILKKL-----IRRTKD-TLGAPKN--NRILIFIDDMNMPVSDMYGAQPPL 2486
            N ++A T E++LK        RRT +  + AP      +++F D++N+P  D YG Q  +
Sbjct: 2621 NFSSATTPELLLKTFDHYCEYRRTPNGVVLAPVQLGKWLVLFCDEINLPDMDKYGTQRVI 2680

Query: 2487 ELIRQLLDLGGVYDTEKNTWKNIQDLSIVAACVPVVN----DISPRLLKHFSMLVLPHPS 2542
              IRQ+++ GG Y T   TW  ++ +  V AC P  +     +S R L+H  ++ + +P 
Sbjct: 2681 SFIRQMVEHGGFYRTSDQTWVKLERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPG 2740

Query: 2543 QDILCTIF----QAHLGIYFSINNFTPEVQKSKDQIISCSLAIYHQVRQNMLPTPTKCHY 2598
               L  I+    +A L +  S+  +         + ++ ++  ++ + Q      T+ HY
Sbjct: 2741 PASLTQIYGTFNRAMLRLIPSLRTYA--------EPLTAAMVEFYTMSQERFTQDTQPHY 2792

Query: 2599 MFNLRDMFKLLLGLLQADRTVVN-SKEMAALLFVHEATRVFHDRLID 2644
            +++ R+M + + G+ +A R +     E    ++ HEA R+F DRL++
Sbjct: 2793 IYSPREMTRWVRGIFEALRPLETLPVEGLIRIWAHEALRLFQDRLVE 2839


>gi|122937398 dynein, cytoplasmic 2, heavy chain 1 [Homo sapiens]
          Length = 4314

 Score =  533 bits (1372), Expect = e-150
 Identities = 472/1937 (24%), Positives = 849/1937 (43%), Gaps = 302/1937 (15%)

Query: 2601 NLRDMFKLLLGLLQADRTVVNSKEMAALLFVHEATRVFH--DRLIDFTDKSLFYRLLSRE 2658
            +L+D+ K   GL+   R   +++ +  LLF HE        DR++ F   SL        
Sbjct: 2606 DLKDVIKK--GLIHYGR---DNQNLDILLF-HEVLEYMSRIDRVLSFPGGSLLLA----- 2654

Query: 2659 LENCFQIGIDGCGKKTCATLACYLTDNKLYRVPISHKCAYIEFKEVFKKVFIHAGLKGKP 2718
                   G  G G++T  +L  ++    L+   IS      +FK   K V   AG++ + 
Sbjct: 2655 -------GRSGVGRRTITSLVSHMHGAVLFSPKISRGYELKQFKNDLKHVLQLAGIEAQQ 2707

Query: 2719 TVLMVPNLNIEQDSFLEDLNYIISSGRIPDLFENVELDSIAMKIRYLTEQSGHMDNRQSL 2778
             VL++ +      +FLE +N ++SSG +P L+   EL+ + + ++    Q G       +
Sbjct: 2708 VVLLLEDYQFVHPTFLEMINSLLSSGEVPGLYTLEELEPLLLPLKDQASQDGFFG---PV 2764

Query: 2779 LSFFQKRIYKNLHIFVIMSPEGPSFRQNCRVYPSMISSCTIDWYERWPEEALLIVANSFL 2838
             ++F  RI +NLHI +IM     +F  NC   P++   C + W E W   ++  +     
Sbjct: 2765 FNYFTYRIQQNLHIVLIMDSANSNFMINCESNPALHKKCQVLWMEGWSNSSMKKIPEMLF 2824

Query: 2839 KE-----KVNFENRENLKEK------LAPTCVQIHKSMKDLNRKYFEETGRFYYTTPNSY 2887
             E     K N + R+  K+K         + + IH+S K             Y  TP+ Y
Sbjct: 2825 SETGGGEKYNDKKRKEEKKKNSVDPDFLKSFLLIHESCKA------------YGATPSRY 2872

Query: 2888 LQFMETFAHILRAREEEMQTKRDRFHMGLSTILEATTLVTEMQEELLILGPQVEQKTKET 2947
            + F+  ++ I  ++++E+  ++     G+S + EA  LV E+  +       ++ K  E 
Sbjct: 2873 MTFLHVYSAISSSKKKELLKRQSHLQAGVSKLNEAKALVDELNRKAGEQSVLLKTKQDEA 2932

Query: 2948 ETLMEKLRKDSQVVEKVQMLVKQDEEIVAEEVRIVEDYAQKTANELKSVLPAFDKAIVAL 3007
            +  ++ +    Q   + +  +++ +  +AEEV  +E+   K  +ELK V P  ++A +A+
Sbjct: 2933 DAALQMITVSMQDASEQKTELERLKHRIAEEVVKIEERKNKIDDELKEVQPLVNEAKLAV 2992

Query: 3008 NALDKADVAELRVYTRPPFLVLTVMNAVCILLQK-KPNWATAKLLLSETGFLKKLINLDK 3066
              +    ++E+R    PP ++  ++  V  L+     +W + K  L++ G  + +   D 
Sbjct: 2993 GNIKPESLSEIRSLRMPPDVIRDILEGVLRLMGIFDTSWVSMKSFLAKRGVREDIATFDA 3052

Query: 3067 DSIPDKVFVKLKKIV--TLPDFNPHKISLVSVACCSLCQWVIALNNYHEVQKVVGPKQIQ 3124
             +I  ++   +++++      F+P      S A   L  WV A   Y  V + + P + +
Sbjct: 3053 RNISKEIRESVEELLFKNKGSFDPKNAKRASTAAAPLAAWVKANIQYSHVLERIHPLETE 3112

Query: 3125 VAEAQNVLKIARQRLAEKQRGLQLVEEHLLFLQAAYKDTVAEKQLLANRKTMASRRFQCA 3184
             A  ++ LK    R  + +  L  V + +  L+  ++   +E   L    + A    + A
Sbjct: 3113 QAGLESNLKKTEDRKRKLEELLNSVGQKVSELKEKFQSRTSEAAKLEAEVSKAQETIKAA 3172

Query: 3185 SVLLTVLEDEKTRWQETINQIDNKLEGILGDILLSAACIVYSGILTPEFRQLIVNKWETF 3244
             VL+  L+ E  RW   + +I  +L  +     L+AA I Y        R+  + +W   
Sbjct: 3173 EVLINQLDREHKRWNAQVVEITEELATLPKRAQLAAAFITYLSAAPESLRKTCLEEWTKS 3232

Query: 3245 CIENGISLSSKFSLIKVMAQKYEISRWHNQGLPHGQYSVENAILIKNG---QQW----PL 3297
                G+    KF L + +  + E   W ++GLP    S+ENA++I      + W    P 
Sbjct: 3233 A---GLE---KFDLRRFLCTESEQLIWKSEGLPSDDLSIENALVILQIIGLKSWSRVCPF 3286

Query: 3298 LIDPHRQAHKWIR-QMEGSRLQKLSIEDSNYTKKIENAMKTGGSVLLQNLLETLAPGLKA 3356
            LIDP  QA +W++  ++ SRL+ ++ +DSN+   +E A++ G ++++Q + + + P L  
Sbjct: 3287 LIDPSSQATEWLKTHLKDSRLEVINQQDSNFITALELAVRFGKTLIIQEM-DGVEPVLYP 3345

Query: 3357 ILKKDIYQKKGHYFIRVGDAEFEYNSNFRLYLSTEIDNPHFLPSVYNFVTMINFTVTFQG 3416
            +L++D+  +   Y +++GD   +YN  FRL+LST   NP   P   + VT +NFT T  G
Sbjct: 3346 LLRRDLVAQGPRYVVQIGDKIIDYNEEFRLFLSTRNPNPFIPPDAASIVTEVNFTTTRSG 3405

Query: 3417 LQDQLLSTVVTHEVPHLEDQRSKLLESISLDAITLEELEEKTLNLLQKALGSILDDDKIV 3476
            L+ QLL+  + HE P LE+Q++KLL+      I L +LEE  L  L  + G+IL++  ++
Sbjct: 3406 LRGQLLALTIQHEKPDLEEQKTKLLQQEEDKKIQLAKLEESLLETLATSQGNILENKDLI 3465

Query: 3477 DTLRKSKMTSNEISKRIEATKKAESEIQAIRKNYLPIATRGALLYFLVADLTQINYMYQF 3536
            ++L ++K +S  I + ++ + K +  +   R  YLP+A   + +YF+++DL++IN MY+F
Sbjct: 3466 ESLNQTKASSALIQESLKESYKLQISLDQERDAYLPLAESASKMYFIISDLSKINNMYRF 3525

Query: 3537 SLDWFHQVFVSSVVSKSKEQEHSFKREKVSPKEVHEFISISKEPNLENEKNLLDKHIKSA 3596
            SL  F ++F  ++ +K   +                                 ++ I+S 
Sbjct: 3526 SLAAFLRLFQRALQNKQDSEN-------------------------------TEQRIQSL 3554

Query: 3597 IDMLTKSIFKVVSSALFNEDKLCFSFRLCTVIMQNNANGNLIQDDIGFLPEEEWNIFLYS 3656
            I  L   +++ +   LF  D+L F+            +  L Q       E EW+ F  +
Sbjct: 3555 ISSLQHMVYEYICRCLFKADQLMFALHFV-----RGMHPELFQ-------ENEWDTF--T 3600

Query: 3657 GILIN--IKSALSQSRLTSTFEIGESQHLQWLSDSR-WRQCQYVSTHLEPFSLLCKSLLS 3713
            G+++   ++ A SQ ++         Q   W+   R W            +  LC     
Sbjct: 3601 GVVVGDMLRKADSQQKI-------RDQLPSWIDQERSWAVATLKIALPSLYQTLC---FE 3650

Query: 3714 NVSQWDTFKNSKAVYSLISTPFSSENASLEENTKPPEETELLNENKETCNPINFPWEKLT 3773
            + + W T+ N+    S+    F S  A                             +K++
Sbjct: 3651 DAALWRTYYNN----SMCEQEFPSILA-----------------------------KKVS 3677

Query: 3774 SFQRLILVKVLRPESLNNSVRKFITEKMGNKYLQRTGVNLKDAYKGSNARTPLILIQTHG 3833
             FQ++++V+ LRP+ L +++  F  + +G K +    +NLK  YK +    P+++I + G
Sbjct: 3678 LFQQILVVQALRPDRLQSAMALFACKTLGLKEVSPLPLNLKRLYKETLEIEPILIIISPG 3737

Query: 3834 IDLTNILLRFAQ-ELKGTTHHVTIISLGRDQAAKAEDLILKALTKTQQWVFLQNCHLATS 3892
             D +  L   A  E  G  +H   +++G+ QA  A  + LK   +   W+ L+N HL  S
Sbjct: 3738 ADPSQELQELANAERSGECYHQ--VAMGQGQADLAIQM-LKECARNGDWLCLKNLHLVVS 3794

Query: 3893 FMPRLCTIVESFNSPNVTIDPE--FRLWLSSKSYSSFPIPVLKKGLKIAVESPQGLKSNL 3950
            ++P    + +  N    T+ P+  FRLWL+++ + +F   +L+  LKI  ESP GLK NL
Sbjct: 3795 WLP---VLEKELN----TLQPKDTFRLWLTAEVHPNFTPILLQSSLKITYESPPGLKKNL 3847

Query: 3951 LQTFGCTGSGEVTEEIFENPDCGQWWKKLLFSLCFFNAVINERKNYGILGWNIAYKFNSS 4010
            ++T+         E+I +  +  +     LFSL +F+A   ER+NY   GW   Y+F+ S
Sbjct: 3848 MRTY----ESWTPEQISKKDNTHR--AHALFSLAWFHAACQERRNYIPQGWTKFYEFSLS 3901

Query: 4011 DLGVAIKVLENSLRGQPSISWQALRYLIGEVIYGGRVIDNWDKRCLKTLLYKFCNPEVL- 4069
            DL     +++    G   + W+ +  L+   IYGGR+ + +D R L++ L +F N  V+ 
Sbjct: 3902 DLRAGYNIIDRLFDGAKDVQWEFVHGLLENAIYGGRIDNYFDLRVLQSYLKQFFNSSVID 3961

Query: 4070 -------KDDFSFS----RSASIKDYIHIIQSLPDDDLPEVLGIHPEAIRSCWETQGEKF 4118
                   K  F +S    +S SI DY  +I+ +P+DD P   G+     RS       + 
Sbjct: 3962 VFNQRNKKSIFPYSVSLPQSCSILDYRAVIEKIPEDDKPSFFGLPANIARSSQRMISSQV 4021

Query: 4119 IENLIAMQPKTTTANLMIRPEQSKDELVMEILSDLLKRLPLTVEKEEIAVGTPSTLKSMM 4178
            I  L  +    T  +   R      E+    LS +L                        
Sbjct: 4022 ISQLRILGRSITAGSKFDR------EIWSNELSPVL------------------------ 4051

Query: 4179 SSSIWESLSKNLKDHDPLIH-----------CVLLTFLKQEIKRFDKLLFVIHKSLKDLQ 4227
              ++W+ L++N      LIH             +L+F+  E     +L+  +H+SL  L 
Sbjct: 4052 --NLWKKLNQN----SNLIHQKVPPPNDRQGSPILSFIILEQFNAIRLVQSVHQSLAALS 4105

Query: 4228 LAIKGEIILTQELEEIFNSFLNMRVPTLWQKHAYRSCKPLSSWIDDLIQRLNFFNTWAKV 4287
              I+G  +L+ E++++ ++ LN + P  WQ        PL  ++  L+ R      W   
Sbjct: 4106 KVIRGTTLLSSEVQKLASALLNQKCPLAWQSKWEGPEDPL-QYLRGLVARALAIQNWVDK 4164

Query: 4288 AYTAIQRRYMRFVTVWKQSIPSTSQKCKHPEDSENNFFEGFPSRYWLPAFFFPQAFLAAV 4347
            A               KQ++ S +                      L   F P  FL A+
Sbjct: 4165 AE--------------KQALLSETLD--------------------LSELFHPDTFLNAL 4190

Query: 4348 LQDYGRSRGIAVDALTFTHHVISNTTDKDEKFSVFMPKKLNIVRRAFKGS-ASSHTGVYI 4406
             Q+  R+ G +VD+L F                            ++KG    +   + I
Sbjct: 4191 RQETARAVGRSVDSLKFV--------------------------ASWKGRLQEAKLQIKI 4224

Query: 4407 FGLFIEGARWNREQKILEDSLPLEMCCDFPDIYFLPTKISTKTPNASNQTDSELYAFECP 4466
             GL +EG  ++  Q + E+ L      D P +  +        P  +    S       P
Sbjct: 4225 SGLLLEGCSFDGNQ-LSENQL------DSPSVSSVLPCFMGWIPQDACGPYSPDECISLP 4277

Query: 4467 VYQTPERSRILATTGLP 4483
            VY + ER R++    +P
Sbjct: 4278 VYTSAERDRVVTNIDVP 4294



 Score =  516 bits (1329), Expect = e-145
 Identities = 385/1314 (29%), Positives = 635/1314 (48%), Gaps = 157/1314 (11%)

Query: 794  LIQSVIEKKNKNLLEVVESSLQQLECDPTEIEEFL-------EHFIFLNAISSKISKLEK 846
            LIQ + +    +L + +++ L +++   TE  E L       E     N   SK+ + + 
Sbjct: 922  LIQKLFDLLVLSLKKSIQAHLHEIDTFVTEAMEVLTIMPQSVEEIGDANLQYSKLQERKP 981

Query: 847  EFLTMSQLYSVAKHHQIHISEEQIAIFQVLLLKFSQLKSSMKLSKINKDTAITKFRDNLE 906
            E L + Q           ++   +     L  K+ + +  M+  ++     I   + N++
Sbjct: 982  EILPLFQEAEDKNRLLRTVAGGGLETISNLKAKWDKFELMMESHQLMIKDQIEVMKGNVK 1041

Query: 907  ACISGLHVDVGNLKAKIRTPLLLCAGTQVSTAMEMIQTLSGEAASLTNKAKAYSHYQDCF 966
            + +   + ++   KA+           Q+    ++I+T  G+  +L   AK     +  F
Sbjct: 1042 SRLQIYYQELEKFKAR---------WDQLKPGDDVIET--GQHNTLDKSAKLIKEKKIEF 1090

Query: 967  SDSQ-------SHMHSVNVEEITQIVLSEISDIEGDLTLRKKLWEAQEEWKRASWEWRNS 1019
             D +          H   +EE    + S IS    D+    ++W   EE+++   E  N 
Sbjct: 1091 DDLEVTRKKLVDDCHHFRLEEPNFSLASSISK---DIESCAQIWAFYEEFQQGFQEMANE 1147

Query: 1020 SLQSIDVESVQRNVSKLMHIISVLEKGLPKSDMVTHLKQVVTEFKQELPIIIALGNPCLK 1079
               +   ++       LM+    L K    S M   L+  V ++K  +PI+  +    L 
Sbjct: 1148 DWITFRTKTYLFE-EFLMNWHDRLRKVEEHSVMTVKLQSEVDKYKIVIPILKYVRGEHLS 1206

Query: 1080 PRHWEALQEIIGKSVPLDKNCKVENLLALKMFQYEN-------EINDMSTSATNEAALEK 1132
            P HW  L  ++G    L +   +E LL   + +  +       ++ D+++ A  E  + +
Sbjct: 1207 PDHWLDLFRLLG----LPRGTSLEKLLFGDLLRVADTIVAKAADLKDLNSRAQGEVTIRE 1262

Query: 1133 MLFKIIDFWNTTPLPLILHHTEIYS--IFIIPSIDDISAQLEESQVILATIKGSPHIGPI 1190
             L + +D W    +  ++ + +  S  + +I    DI  Q+ +++ +L ++K SP+    
Sbjct: 1263 AL-RELDLWGVGAVFTLIDYEDSQSRTMKLIKDWKDIVNQVGDNRCLLQSLKDSPYYKGF 1321

Query: 1191 KDLVNEWDQNLTLFSYTLEEWMNCQRNWLYLEPVFHSSEIRRQLPAETELFSQVISMWKK 1250
            +D V+ W++ L      L+   + QR W+YLEP+F     R  LP E   F++V   ++ 
Sbjct: 1322 EDKVSIWERKLAELDEYLQNLNHIQRKWVYLEPIFG----RGALPKEQTRFNRVDEDFRS 1377

Query: 1251 IMSKIQNKQNALQITTSAGVLEILQNCNIHLEHIKKSLEDYLEVKRLIFPRFYFLSNAEL 1310
            IM+ I+       +TT AG+   L      L+  +KSL ++LE KR  FPRFYF+ + +L
Sbjct: 1378 IMTDIKKDNRVTTLTTHAGIRNSLLTILDQLQRCQKSLNEFLEEKRSAFPRFYFIGDDDL 1437

Query: 1311 LDILADSRNPESVQPHLVKCFENIKQLLIWKQDIGPPAVKMLISAEGEGLVLPKKIRVRS 1370
            L+IL  S NP  +Q HL K F  I  +   ++     A+K L   EGE +    K+ + +
Sbjct: 1438 LEILGQSTNPSVIQSHLKKLFAGINSVCFDEKSKHITAMKSL---EGEVVPFKNKVPLSN 1494

Query: 1371 AVEQWL----VNVEKSMFDVLKK-------------ERYIYNIILLFQSQIMFYNDCVKS 1413
             VE WL    + ++K++  +LK+                  + IL    QI F  D V++
Sbjct: 1495 NVETWLNDLALEMKKTLEQLLKECVTTGRSSQGAVDPSLFPSQILCLAEQIKFTED-VEN 1553

Query: 1414 FVSSYSREKLEKVHAGLMCHLEEVADLVVLDTSNSRTKA-----ILGALLILYVHCRDIV 1468
             +  +S   L ++   L+  LE+  ++         T++      L AL++  +H  D+V
Sbjct: 1554 AIKDHS---LHQIETQLVNKLEQYTNIDTSSEDPGNTESGILELKLKALILDIIHNIDVV 1610

Query: 1469 INLLLKNIFNAEDFEWTRHLQYKWNEKQKLCYVSQGNASFTYGYEYLGCTSRLVITPLTD 1528
              L    +   ED+ W + L++ + +    C V   ++ F Y YEY G  S+LV TPLTD
Sbjct: 1611 KQLNQIQVHTTEDWAWKKQLRF-YMKSDHTCCVQMVDSEFQYTYEYQGNASKLVYTPLTD 1669

Query: 1529 RCWLTLMEALHLNLGGCPAGPAGTGKTETVKDLAKSLGKHCVVFNCFEDLDYKIVRKFFF 1588
            +C+LTL +A+ + LGG P GPAGTGKTE+VK L   LG+  +VFNC E +D K + + F 
Sbjct: 1670 KCYLTLTQAMKMGLGGNPYGPAGTGKTESVKALGGLLGRQVLVFNCDEGIDVKSMGRIFV 1729

Query: 1589 GLVQSGAWSCFDEFNLIDLEVLSVIASQILTIKAAKDNYSARFVLEGKEIRINMSCAVFI 1648
            GLV+ GAW CFDEFN ++  VLS ++ QI TI+ A  N+     L GKE+ +N +  +FI
Sbjct: 1730 GLVKCGAWGCFDEFNRLEESVLSAVSMQIQTIQDALKNHRTVCELLGKEVEVNSNSGIFI 1789

Query: 1649 TMNPR---YGGGVELPDNLKSLFRPVAMMVPHYQMIAEIILFSFGFKSANSLSGKLTNLY 1705
            TMNP    YGG  +LPDNLK LFRPVAM  P  ++IAE+IL+S GFK A  LS KL  ++
Sbjct: 1790 TMNPAGKGYGGRQKLPDNLKQLFRPVAMSHPDNELIAEVILYSEGFKDAKVLSRKLVAIF 1849

Query: 1706 ELARKQLSQQDHYNFGLRSLKIVLIMAGTKKREFK---CLSEADETLIVIEAIREASLPK 1762
             L+R+ L+ Q HY++GLR+LK VL  +G   R+         A+E+ IV++A+R  ++ K
Sbjct: 1850 NLSRELLTPQQHYDWGLRALKTVLRGSGNLLRQLNKSGTTQNANESHIVVQALRLNTMSK 1909

Query: 1763 CPPEDVPLFENIIGDIFPEVTVLKVNQLALEKVIYTATQQLGLQNWSSQKEKIIQFYNQL 1822
                D   F+ +I D+FP + + +V    L   +    ++   +   +Q +K ++ Y QL
Sbjct: 1910 FTFTDCTRFDALIKDVFPGIELKEVEYDELSAALKQVFEEANYEIIPNQIKKALELYEQL 1969

Query: 1823 QVCVGVMLVGPTGGGKTTVRRILEKALTLLPIADFLSVAERKSASKISERKGK-VDICVL 1881
               +GV++VGP+G GK+T+ R+L  AL                      + GK V    +
Sbjct: 1970 CQRMGVVIVGPSGAGKSTLWRMLRAALC---------------------KTGKVVKQYTM 2008

Query: 1882 NPKCVTLSELYGQLDPNTMEWTDGLLSATIRSYVYFNTPKNTKKDIDLRLKSRISDLSNV 1941
            NPK +   +L G +D +T EW+DG+L+ + R                             
Sbjct: 2009 NPKAMPRYQLLGHIDMDTREWSDGVLTNSAR----------------------------- 2039

Query: 1942 FKLDSSDTTETDDNIFEEIEKVVKIPENHNFDWQWIILDGPVDTFWVENLNSVLDDTRTL 2001
                                +VV+ P++ +    WII DG +D  W+E+LNSVLDD R L
Sbjct: 2040 --------------------QVVREPQDVS---SWIICDGDIDPEWIESLNSVLDDNRLL 2076

Query: 2002 CLANSERIALTNKIRVIFEVDNLSQASPATVSRCAMVYMDPVDLGWEPYVKSWL 2055
             + + ERI     +  +FE  +LS ASPAT+SR  M+++   +      +KSWL
Sbjct: 2077 TMPSGERIQFGPNVNFVFETHDLSCASPATISRMGMIFLSDEETDLNSLIKSWL 2130



 Score = 60.5 bits (145), Expect = 4e-08
 Identities = 59/246 (23%), Positives = 117/246 (47%), Gaps = 19/246 (7%)

Query: 2428 STINFSTNVTAAKTKEMILKKL------IRRTKDTLGAPKN-NRILIFIDDMNMPVSDMY 2480
            ST   + + +A  T   +L+KL      I      +  PK+  R+++++ D+N+P  D +
Sbjct: 2310 STQIATVHCSAQTTSRHLLQKLSQTCMVISTNTGRVYRPKDCERLVLYLKDINLPKLDKW 2369

Query: 2481 GAQPPLELIRQLLDLGGVYDTEKNTWKNIQDLSIVAACVPVVNDISPRLLKHFSMLV--- 2537
            G    +  ++Q+L   G YD E   W  ++++ IVA+          +L   F+ +V   
Sbjct: 2370 GTSTLVAFLQQVLTYQGFYD-ENLEWVGLENIQIVASMSAGGRLGRHKLTTRFTSIVRLC 2428

Query: 2538 -LPHPSQDILCTIFQAHLG--IYFSINNFTPEVQKSKDQIISCSLA-IYHQVRQNMLPTP 2593
             + +P ++ L TI+ A+L   ++ ++ N +     SK  +++ S+  +Y QVR       
Sbjct: 2429 SIDYPEREQLQTIYGAYLEPVLHKNLKNHSIWGSSSKIYLLAGSMVQVYEQVRAK-FTVD 2487

Query: 2594 TKCHYMFNLRDMFKLLLGLLQADRTVVNSK---EMAALLFVHEATRVFHDRLIDFTDKSL 2650
               HY F    + + +LGL + D    +S    +    +  +EA R+F D+++   +  L
Sbjct: 2488 DYSHYFFTPCILTQWVLGLFRYDLEGGSSNHPLDYVLEIVAYEARRLFRDKIVGAKELHL 2547

Query: 2651 FYRLLS 2656
            F  +L+
Sbjct: 2548 FDIILT 2553


>gi|149944493 dynein, axonemal, heavy polypeptide 14 isoform 3 [Homo
           sapiens]
          Length = 228

 Score =  439 bits (1129), Expect = e-122
 Identities = 217/217 (100%), Positives = 217/217 (100%)

Query: 1   METFIPIDLTTENQEMDKEETKTKPRLLRYEEKKYEDVKPLETQPAEIAEKETLEYKTVR 60
           METFIPIDLTTENQEMDKEETKTKPRLLRYEEKKYEDVKPLETQPAEIAEKETLEYKTVR
Sbjct: 1   METFIPIDLTTENQEMDKEETKTKPRLLRYEEKKYEDVKPLETQPAEIAEKETLEYKTVR 60

Query: 61  TFSESLKSEKTEDYLRESIIQQHMVSPEPASLKEKGKSRRKKDQTHACPNVRKARPVSYD 120
           TFSESLKSEKTEDYLRESIIQQHMVSPEPASLKEKGKSRRKKDQTHACPNVRKARPVSYD
Sbjct: 61  TFSESLKSEKTEDYLRESIIQQHMVSPEPASLKEKGKSRRKKDQTHACPNVRKARPVSYD 120

Query: 121 RTEPKDDDVIRNIIRLREKLGWQTILPQHSLKYGSSKIAIQKITLKKPLEDDGEFVYCLP 180
           RTEPKDDDVIRNIIRLREKLGWQTILPQHSLKYGSSKIAIQKITLKKPLEDDGEFVYCLP
Sbjct: 121 RTEPKDDDVIRNIIRLREKLGWQTILPQHSLKYGSSKIAIQKITLKKPLEDDGEFVYCLP 180

Query: 181 RKSPKSLYNPYDLQVVSAHTAKHCKEFWVITASFISK 217
           RKSPKSLYNPYDLQVVSAHTAKHCKEFWVITASFISK
Sbjct: 181 RKSPKSLYNPYDLQVVSAHTAKHCKEFWVITASFISK 217


>gi|114155135 dynein, axonemal, heavy chain 9 isoform 1 [Homo sapiens]
          Length = 798

 Score =  292 bits (748), Expect = 4e-78
 Identities = 252/999 (25%), Positives = 428/999 (42%), Gaps = 217/999 (21%)

Query: 3526 DLTQINYMYQFSLDWFHQVFVSSVVSKSKEQEHSFKREKVSPKEVHEFISISKEPNLENE 3585
            DL++I+ MYQFSL  F  VF  +V             E+ +P E                
Sbjct: 3    DLSKIHPMYQFSLKAFSIVFQKAV-------------ERAAPDES--------------- 34

Query: 3586 KNLLDKHIKSAIDMLTKSIFKVVSSALFNEDKLCFSFRLCTVIMQNNANGNLIQDDIGFL 3645
               L + + + ID +T S+++     LF  DKL +  +L   I+  N   N ++ D    
Sbjct: 35   ---LRERVANLIDSITFSVYQYTIRGLFECDKLTYLAQLTFQILLMNREVNAVELD---- 87

Query: 3646 PEEEWNIFLYSGILINIKSALSQSRLTSTFEIGESQHLQWLSDSRWRQCQYVSTHLEPFS 3705
                   FL                L S  + G +  +++LS   W   + +S+ +E FS
Sbjct: 88   -------FL----------------LRSPVQTGTASPVEFLSHQAWGAVKVLSS-MEEFS 123

Query: 3706 LLCKSLLSNVSQWDTFKNSKAVYSLISTPFSSENASLEENTKPPEETELLNENKETCNPI 3765
             L + +  +   W  F  S+                       PE+ +L  E        
Sbjct: 124  NLDRDIEGSAKSWKKFVESEC----------------------PEKEKLPQE-------- 153

Query: 3766 NFPWEKLTSFQRLILVKVLRPESLNNSVRKFITEKMGNKYLQRTGVNLKDAYKGSNARTP 3825
               W+  T+ QRL +++ +RP+ +  ++R F+ EK+G+KY+    ++   +++ S   TP
Sbjct: 154  ---WKNKTALQRLCMLRAMRPDRMTYALRDFVEEKLGSKYVVGRALDFATSFEESGPATP 210

Query: 3826 LILIQTHGIDLTNILLRFAQELKGTTHHVTI--ISLGRDQAAKAEDLILKALTKTQQWVF 3883
            +  I + G+D    +    ++L  T ++     +SLG+ Q   AE   L    K   WV 
Sbjct: 211  MFFILSPGVDPLKDVESQGRKLGYTFNNQNFHNVSLGQGQEVVAE-AALDLAAKKGHWVI 269

Query: 3884 LQNCHLATSFMPRLCTIVESFNSPNVTIDPEFRLWLSSKSYSS-----FPIPVLKKGLKI 3938
            LQN HL   +   L T+ +     +    PEFR+++S++   S      P  +L+  +KI
Sbjct: 270  LQNIHLVAKW---LSTLEKKLEEHSENSHPEFRVFMSAEPAPSPEGHIIPQGILENSIKI 326

Query: 3939 AVESPQGLKSNLLQTFGCTGSGEVTEEIFENPDCGQWWKKLLFSLCFFNAVINERKNYGI 3998
              E P G+ +NL +          T++  E       +K +LF+LC+F+AV+ ER+ +G 
Sbjct: 327  TNEPPTGMHANLHKALD-----NFTQDTLEMCSRETEFKSILFALCYFHAVVAERRKFGP 381

Query: 3999 LGWNIAYKFNSSDLGVAIKVLENSLRGQPSISWQALRYLIGEVIYGGRVIDNWDKRCLKT 4058
             GWN +Y FN+ DL +++ VL N L     + +  LRYL GE++YGG + D+WD+R  +T
Sbjct: 382  QGWNRSYPFNTGDLTISVNVLYNFLEANAKVPYDDLRYLFGEIMYGGHITDDWDRRLCRT 441

Query: 4059 LLYKFCNPEVLKDDFSFS------RSASIKDYIHIIQSLPDDDLPEVLGIHPEAIRSCWE 4112
             L +F  PE+L+ + S +       +     Y   I +    + P + G+HP A      
Sbjct: 442  YLGEFIRPEMLEGELSLAPGFPLPGNMDYNGYHQYIDAELPPESPYLYGLHPNAEIGFLT 501

Query: 4113 TQGEKFIENLIAMQPKTTTANLMIRPEQSKDELVMEILSDLLKRLPLTVEKEEIAVGTPS 4172
               EK    ++ +QP+ + A        +++E V  +L ++L+R+      +E  +    
Sbjct: 502  QTSEKLFRTVLELQPRDSQAR--DGAGATREEKVKALLEEILERV-----TDEFNI---- 550

Query: 4173 TLKSMMSSSIWESLSKNLKDHDPLIHCVLLTFLKQEIKRFDKLLFVIHKSLKDLQLAIKG 4232
                         L   +++  P I   ++ F  QE  R + L   I +SL++L+L +KG
Sbjct: 551  -----------PELMAKVEERTPYI---VVAF--QECGRMNILTREIQRSLRELELGLKG 594

Query: 4233 EIILTQELEEIFNSFLNMRVPTLWQKHAYRSCKPLSSWIDDLIQRLNFFNTWAKVAYTAI 4292
            E+ +T  +E + N+     VP  W + AY S   L++W  DL+ R+     W        
Sbjct: 595  ELTMTSHMENLQNALYFDMVPESWARRAYPSTAGLAAWFPDLLNRIKELEAWT------- 647

Query: 4293 QRRYMRFVTVWKQSIPSTSQKCKHPEDSENNFFEGFPSRYWLPAFFFPQAFLAAVLQDYG 4352
                                          +F    PS  WL  FF PQ+FL A++Q   
Sbjct: 648  -----------------------------GDF--TMPSTVWLTGFFNPQSFLTAIMQSTA 676

Query: 4353 RSRGIAVDALTFTHHVISNTTDKDEKFSVFMPKKLNIVRRAFKGSASSHTGVYIFGLFIE 4412
            R     +D +        + T K+              R  F+  +    G YI GLF+E
Sbjct: 677  RKNEWPLDQMALQ----CDMTKKN--------------REEFR--SPPREGAYIHGLFME 716

Query: 4413 GARWNREQKILEDSLPLEMCCDFPDIYFLPTKISTKTPNASNQTDSELYAFECPVYQTPE 4472
            GA W+ +  I+ ++   ++    P ++        K   A  Q    +Y+  CPVY+T +
Sbjct: 717  GACWDTQAGIITEAKLKDLTPPMPVMFI-------KAIPADKQDCRSVYS--CPVYKTSQ 767

Query: 4473 RSRILATTGLPTNFLTSVYLSTKKPPSHWITMRVALLCE 4511
            R         PT ++ +  L TK+ PS W+   VALL +
Sbjct: 768  RG--------PT-YVWTFNLKTKENPSKWVLAGVALLLQ 797


>gi|222144249 dynein heavy chain domain 1 isoform 1 [Homo sapiens]
          Length = 4753

 Score =  171 bits (434), Expect = 1e-41
 Identities = 245/1263 (19%), Positives = 466/1263 (36%), Gaps = 232/1263 (18%)

Query: 941  MIQTLSGEAASLTNKAKAYSH--------YQDCFSDSQS--HMHSVNVEEITQIVLSEIS 990
            + + LSG     T   ++  H        +Q+  SD     H +++  E+ T + L    
Sbjct: 952  LAKALSGPFMDPTQDQRSTEHQLVSLERQFQNTVSDLSELHHAYAIFTEDETPVPLPICG 1011

Query: 991  DIEGDLTLRKKLWEAQEEWKRASWEWRNSSLQSIDVESVQRNVSKLMHIISVLEKGLP-K 1049
                 +  ++++W           EW+  +         Q      +   + +   L   
Sbjct: 1012 T--RPIVQQQRIWHLYRVISENISEWKCMAFAKFSPAMAQEKTEGWLTEAARMSTTLELH 1069

Query: 1050 SDMVTHLKQVVTEFKQELPIIIALGNPCLKPRHWEALQEIIGK-SVPLDKNCKVENLLAL 1108
            S ++ H  +++ EF+  LP++  LG+   +  + + L   +G  S+   +   +  LL  
Sbjct: 1070 SPVLQHCMRILGEFRSYLPLLTKLGSLHPQSLNCQCLLRALGLGSLQTIELLTLGQLLTY 1129

Query: 1109 KMFQYENEINDMSTSATNEAALEKMLFKIIDFWNTTPLPL---ILH-------------- 1151
             + ++ + IN +  +       ++ + ++  +W    L L   ILH              
Sbjct: 1130 PLLEFADRINQVWQNENERIHAQETIRRLQRYWEARQLRLLNFILHVPYEPPASERSKRQ 1189

Query: 1152 -----HTEIYS----IFIIPSIDDISAQLEESQVILATIKGSPHIGPIKDLVNEWDQNLT 1202
                   E+       FI+    ++   ++ES  +L+ I      G +  +  EW   + 
Sbjct: 1190 VLRSPQWEVVDKDSGTFILSDYSNLQDSIQESLQVLSKILAIEKSGDLNKIALEWVAIMH 1249

Query: 1203 LFSYTLEEWMNCQRNWLYLEPVFHSSEIRRQLPAETELFSQVISMWKKIMSKIQNKQNAL 1262
                 LE W+  Q+ W++L  V H  +I+         F  +   ++ +M         L
Sbjct: 1250 GLGALLEVWLTFQQKWIFLNKVLHEMKIQFPNADLNSRFKVMDDQYRTLMRISVADPMVL 1309

Query: 1263 QITTSAG----------VLEILQNCNIHLEHIKKSLEDYLEVKRLIFPRFYFLSNAELLD 1312
             +   +           + ++LQ  ++ LE I  SLE  L      FPR +FLS++EL+ 
Sbjct: 1310 SLVVPSAERSPYFQGQQLQQLLQAGSVELEGIIMSLESVLYGVCAHFPRLFFLSDSELVA 1369

Query: 1313 ILADSRNPESVQPHLVKCFENIKQLLI------------WKQDIGPPA---VKMLISAEG 1357
            +LA        Q  + +CF ++  +              W+             ++ A G
Sbjct: 1370 LLAARLESCEAQLWVRRCFPHVHAVSFRSCPTGEKNTDDWESSPNTQTQVEALAVLGAGG 1429

Query: 1358 EGLVLPKKIRVRSAVEQWLVNVEK----------------------SMFDVLKK------ 1389
            E + L   + +   + +WL ++EK                      S+ + LK+      
Sbjct: 1430 EEVKLQGPLPLHPDLPKWLASLEKCLRLALVHMLQGCVAARLARGPSLGEALKQLPKQNK 1489

Query: 1390 ---ERYIYNIILLFQSQIMFYNDCVKSFVSSYSREKLEKVH------AGLMCHLEEVADL 1440
               + Y+ + I L Q+   F   CV        R ++E+        A +  H+ ++  L
Sbjct: 1490 LYLQLYVQHWIDLVQA---FPWQCVLVAEEVVWRAEMEEALLEWGTLAMVSMHMRKLEVL 1546

Query: 1441 VVL-----------DTSNSRTKAILGALLILYVHCRDIVINLLLKNIFNAEDFEWTRHLQ 1489
            V                + R  ++L ALL++ V  RDI   L    + +  DF W R L+
Sbjct: 1547 VNFMRAQRASQGGQSLPSVRQTSLLSALLVMAVTHRDIAQLLEQHQVSDLTDFHWVRQLK 1606

Query: 1490 YKWNEKQKL----------------------CYVSQGNASFTYGYEYLGCTSRLVITPLT 1527
            Y       +                      C++     SF Y YEYLG     + + L 
Sbjct: 1607 YHLGSPHIIPKSPLQSLKTIASSEPSLSPAACWIDVLGRSFLYNYEYLGPRLGPLPSLLP 1666

Query: 1528 DRCWLTLMEALHLNLGGCPAGPAGTGKTETVKDLAKSLGKHCVVFNCFEDLDYKIVRKFF 1587
            +R  L L+ AL     G   GP G GK   V  LA++LG+  V+  C   ++ + +  + 
Sbjct: 1667 ERPALVLLLALEEVACGTVLGPNGVGKRAIVNSLAQALGRQLVMLPCSPQIEAQCLSNYL 1726

Query: 1588 FGLVQSGAWSCFDEFNLIDLEVLSVIASQI------------------LTIKAAKDNYSA 1629
             G +Q GAW   ++ + +   +LS +  ++                   TI   +     
Sbjct: 1727 NGALQGGAWLLLEKVHQLPPGLLSALGQRLGELHHLYAPLYQEASRNTSTIDPTQPQLLG 1786

Query: 1630 RFVLEGKEIRINMSCAVFITMNPRYGGGVELPDNLKSLFRPVAMMVPHYQMIAEIILFSF 1689
                E   + + +     + +         +P NL  L RPVA+ +P  + +AE+ L   
Sbjct: 1787 SSFFEKHHVSVRLGYGCLLVLRALSSA---VPANLHLLLRPVALALPDLRQVAELTLLGA 1843

Query: 1690 GFKSANSLSGKLTNLYELARKQLSQQDHYNFGL--RSLKIVLIMAGTKKREFKCLSEADE 1747
            G + A  ++ +L+  + L R+ +S        L  + L+  +      K E KC      
Sbjct: 1844 GMRDAFQMATRLSKFFSLERELVSGPLPCRLPLLKQILEDTIRTLNVTKEEPKCQKPRS- 1902

Query: 1748 TLIVIEAIREASLPKCPPEDV------PLFENIIGDIFPEVTVLKVNQLA---LEKVIYT 1798
                + AI EA+L + P   +           ++  +FP  + +    +    ++ ++  
Sbjct: 1903 ----LAAIEEAALLRSPLFSILNGLHLHNLRGLLCALFPSASQVLAEPMTYKLMKPLVVE 1958

Query: 1799 ATQQLGLQNWSSQKEKIIQFYNQLQVCVGVMLVGPTGGGKTTVRRILEKALTLLPIADFL 1858
              QQ+GL         + Q    L    G++L+GP G GKTT    L K           
Sbjct: 1959 ELQQVGLDPSPDILGSLEQLSQALSRASGILLLGPAGSGKTTCWHSLFK----------- 2007

Query: 1859 SVAERKSASKISERKG--KVDICVLNPKCVTLSELYGQLDPNTMEWTDGLLSATIRSYVY 1916
             +  R +A + +  +G   V+I  L P  ++  E  G L+ +   W  G+    +R+   
Sbjct: 2008 -IQNRLAAMEDTSTQGCQPVEITHLYPSGLSPQEFLGWLEGSC--WHHGIFPKVLRAAGQ 2064

Query: 1917 FNTPKNTKKDIDLRLKSRISDLSNVFKLDSSDTTETDDNIFEEIEKVVKIPENHNFDWQW 1976
             N                          +     +T+++I  +                W
Sbjct: 2065 CN--------------------------NMGQKRQTEESIGIQ---------------HW 2083

Query: 1977 IILDGPVDTFWVENLNSVLDDTRTLCLANSERIALTNKIRVIFEVDNLSQASPATVSRCA 2036
            II DG  +  W++++  +L +   L L + ++IA      ++ EV + +  SP  V  CA
Sbjct: 2084 IICDGASNGAWLDSITCLLSELPQLSLPSGQQIARPPGTFLLMEVADTTGISPTVVGCCA 2143

Query: 2037 MVY 2039
            +V+
Sbjct: 2144 LVW 2146



 Score =  157 bits (397), Expect = 2e-37
 Identities = 161/708 (22%), Positives = 306/708 (43%), Gaps = 69/708 (9%)

Query: 2653 RLLSRELENCFQI-GIDGCGKKTCATLACYLTDNKLYRVPISHKCAYIEFKEVFKKVFIH 2711
            R+L+R  ++   + G  G G+ T  TLA  +     + +P   + A ++     +    H
Sbjct: 2877 RVLARPRQHGLLLSGALGTGRHTAITLASSICQAHFFHLPSGSEEAILQ---CLRDASWH 2933

Query: 2712 AGLKGKPTVLMVPNLNIEQDSFLEDLNYIISSGRIPDLFENVELDSIAMKIRYLTEQSGH 2771
            AG+  +P  L+VP+  ++  + L  L  + +SG  P  +   +LD I   +    E  G 
Sbjct: 2934 AGMLSQPVALLVPS-GVDLTT-LHRLLALATSGSFPGQYTEADLDRIGEHLP--RENLGV 2989

Query: 2772 MDN--RQSLLSFFQKRIYKNLHIFVIMSPEGPSFRQNCRVYPSMISSCT--IDWYERWPE 2827
              N  ++ +L  F +++  +LH+F ++  +    +    ++  ++   T  ID YE W +
Sbjct: 2990 KQNIKKEMVLQRFHQQVCSHLHLFFLIGDKQAHKQLPSTLFLRLLQLATASIDRYEPWDQ 3049

Query: 2828 EALLIVANSFLK--EKVNFENRENLKEKLAPTCVQIHKSMK--DLNRKYFEE--TGRFYY 2881
             AL  VA   L+  + V  ++       L  +   + K+M    L+  ++ E        
Sbjct: 3050 AALAKVAQHHLEGAQSVPLDDGSWKYPDLQASIPSVAKAMALIHLSATHYHEHLCPALPL 3109

Query: 2882 TTPNSYLQFMETFAHILRAREEEMQTKRDRFHMGLSTILEATTLVTEMQEELLILGPQVE 2941
             TP ++L F++TF  + +    +++ K  R    L  +     L+ E      ++   +E
Sbjct: 3110 VTPKTFLDFLDTFLMLQQQTILKIKNKAQRVQNALENL---RMLIKEHGTHANLIF-DLE 3165

Query: 2942 QKTKETETLMEKLRKDSQVVEKVQMLVKQDEEIVAEEVRIVEDYAQKT---ANELKSVLP 2998
            Q+ K++    + L    Q +E+ ++L KQ  E    +  ++E+ A++      + ++ L 
Sbjct: 3166 QQLKDSG---KSLSMFQQQLEQSKLLYKQQLEECRHQENLIENLARQRDALQAQREAFLE 3222

Query: 2999 AFDKAIVA-LNALDKADVAELRVYTRPPFLVLTVMNAVCILLQKKPNWATAKLLLSETGF 3057
               KA +  L+ L  AD  E+R Y  PP  V+ V +A+C L   +  WA+AK LL    F
Sbjct: 3223 QMSKAFLEPLSQLQVADFEEIRSYRAPPESVVRVTDAMCDLFHHETGWASAKQLLCTEDF 3282

Query: 3058 LKKLINLDKDSIPDKVFVKLKKIVTLPDFNPHKISLVSVACCSLCQWVIALNNYHEVQKV 3117
             ++L+   K+ I D   +KL  I+  P  +   +  VS    SL  W+ A+ +Y      
Sbjct: 3283 YQELVFFPKEKITDSELIKLHLILKAPGMDDAALRAVSRPAASLAAWLWAVLHYGLAHCR 3342

Query: 3118 VGPKQIQVAEAQNVLKIARQRLAEKQRGLQLVEEHLLFLQAAYKDTVAEKQLLANRKTMA 3177
              P  + + + +  L   + RL   Q   Q   EH L L    +D  A    +A   + A
Sbjct: 3343 GLPTDLLLQQVEATLTREQARLGYYQFQAQETLEHNLALAKMVEDAQASHNCVAKTLSQA 3402

Query: 3178 S----RRFQCASVLLTVLEDEKTRWQETINQIDNKLEGILGDILLSAACIVYSGILTPEF 3233
                  ++   + LLT +      W   + ++  +   + GD LL +A I+Y G   P  
Sbjct: 3403 QCGQYHKWPMKAALLTPMR----AWTTQLQKLKGRCMTVFGDTLLCSAAIIYLGPFPPLR 3458

Query: 3234 RQLIVNKWETFC------------------IENGISLSSK---------FSLIKVMAQKY 3266
            RQ ++++W   C                   +  +S+  K         FS++ +++ + 
Sbjct: 3459 RQELLDEWLALCRGFQEALGPDDVAQALKRKQKSVSIPPKNPLLATHSPFSILSLLSSES 3518

Query: 3267 EISRWHNQGLPHGQYSVENAILIK-----NGQQWPLLIDPHRQAHKWI 3309
            E  +W     P  + +    +L++     +  +WPLL+DP  +A  W+
Sbjct: 3519 EQYQWDGNLKPQAKSAHLAGLLLRSPTHYSSCRWPLLLDPSNEALIWL 3566



 Score = 64.3 bits (155), Expect = 3e-09
 Identities = 176/873 (20%), Positives = 304/873 (34%), Gaps = 159/873 (18%)

Query: 3685 WLSDSRWRQCQYVSTHLEPFSLLCKSLLSNVSQWDTFKNSKAVYSLISTPFSSENASLEE 3744
            WL    W +C+ +   L PF  LC SL  + S W      +A  SL ST           
Sbjct: 3981 WLGPKAWHECEMLEL-LPPFVGLCASLAGHSSAW------QAYLSLSST----------- 4022

Query: 3745 NTKPPEETELLNENKETCNPINFPW-EKLTSFQRLILVKVLRPESLNNSVRKFITEKMGN 3803
                               P   P  E L+  Q+LIL +VLRPE L  ++  F T  +G 
Sbjct: 4023 ----------------VLGPAPGPGPEPLSLLQKLILWRVLRPECLAGALADFTTSLLGR 4066

Query: 3804 KYLQRTGVNLKDAYKGSNARTP-LILIQTHG-----IDLTNILLRFAQELKGTTHHVTII 3857
               + T       +K S A  P LIL+   G     +    ++ + A + +     + +I
Sbjct: 4067 PLDENTYAPTM-PFKHSQATQPMLILLPPPGHPSATLHPLTVIQKLAAKYQQGQKQLQVI 4125

Query: 3858 SLGRDQAAKAEDLILKALTKTQ---QWVFLQNCHLATSFMPRLC---------------- 3898
            +LG  +A     +++  L++      W+ L NCHL   +   L                 
Sbjct: 4126 ALG-SEAWDPVSVVVSTLSQAMYEGHWLVLDNCHLMPHWPKELLQLLLELLGRAKVVADL 4184

Query: 3899 ---TIVESFNSPNV-TIDPEFRLWLSSKSYSSFPIPVLKKGLKIAVESPQGLKSNLLQTF 3954
                +++   S NV T+  +FRLWL   + SS  +P +     + V   Q L+   +   
Sbjct: 4185 ESEQLLDQPESRNVSTVHRDFRLWLIVPAESSASLPAVLTQHSMPVFWNQSLELGHV--- 4241

Query: 3955 GCTGSGEVTEEIFENPDCGQWWKKLLFSLCFFNAVINERKNYGILGWNIAYKFNSSDLGV 4014
                S E+ +++       Q        L   + ++  R+ YG        +++   L  
Sbjct: 4242 -LIDSVELAQQVLYMQPPTQ-----ALPLLLLHGLLLHRQLYGTRLQAHRGRWSQVTLTQ 4295

Query: 4015 AIKVLENSLRGQPSISWQALRYLIGEVIYGGRVIDNWDKRCLKTLLYKFCNPE------- 4067
             ++  ++ L    S    A++ L   V YGG + D  D+  L +L     +P        
Sbjct: 4296 VLQT-QDQLWASLSNPRAAMQELAASVFYGGPLGDTEDREALISLTQACLSPSSGSWVQP 4354

Query: 4068 -----------VLKDDFSFSRSASIKDYIHIIQSLPDDDLPEVLGIHPEAIRSCWETQGE 4116
                        L +       A  K  +H++ S P+   P + G+           Q  
Sbjct: 4355 HTPQSLLATLMPLPELRELDAMAECKAQMHLLPSPPE---PRLCGLSEGPQAWLLRRQSR 4411

Query: 4117 KFIENLIAMQPKTTTANLMIRPEQSKDELVMEILSDLLKRLPLTVEKEEIAVGTPSTLKS 4176
              +  L    P     +   R  Q  +  + + L  + +RL      E +       ++ 
Sbjct: 4412 ALLSALQRSSPVWVPESR--RGAQLAERRLRQRLVQVNRRL------ESLQDLLTHVIRQ 4463

Query: 4177 MMSSSIWESLSKNLKDHDPLIHCVLLTFLKQEIKRFDKLLFVIHKSLKDLQLAIKG-EII 4235
              S + W  L  N +         L   L+ E     +L+  + + L  L   +KG    
Sbjct: 4464 DESDAPWSVLGPNARR-------PLEGVLETEALELSQLVGTLQRDLDCLLQQLKGAPPC 4516

Query: 4236 LTQELEEIFNSFLNMRVPTLWQKHAYRSCKPLSSWIDDLIQRLNFFNTWAKVAYTAIQRR 4295
             ++    + ++    R+P  W+ HA    +P   W+  L +R                + 
Sbjct: 4517 PSRRCAAVAHALWTGRLPLPWRPHAPAGPQPPWHWLRQLSRR---------------GQL 4561

Query: 4296 YMRFVTVWKQSIPSTSQKCKHPEDSENNFFEGFPSRYWLPAFFFPQAFLAAVLQDYGRSR 4355
             +R++ V   +     ++  H                 L AF  P+  L A+  +    +
Sbjct: 4562 LVRYLGVGADASSDVPERVFH-----------------LSAFRHPRRLLLALRGEAALDQ 4604

Query: 4356 GIAVDALTFTHHVISNTTDKDEKFSVFMPKKLNIVRRAFKGSASSHTGVYIFGLFIEGAR 4415
               V +  F     S ++    K        L+              G+ + GL +  A 
Sbjct: 4605 N--VPSSNFPGSRGSVSSQLQYKRLEMNSNPLHFRVENGPNPTVPERGLLLIGLQVLHAE 4662

Query: 4416 WNREQKILEDSLPLEMCCDFPDIYFLPTKISTKTPNASN-QTDSELYAFECPVYQTPERS 4474
            W+     L+DS P       P     P  IST+ P  S+    ++L  + CPVY      
Sbjct: 4663 WDPIAGALQDS-PSSQPSPLP-----PVSISTQAPGTSDLPAPADLTVYSCPVYM----G 4712

Query: 4475 RILATTGLPT-NFLTSVYLSTKKPPSHWITMRV 4506
              L T  L + N +  + L TK  P+  +  RV
Sbjct: 4713 GPLGTAKLQSRNIVMHLPLPTKLTPNTCVQRRV 4745



 Score = 51.6 bits (122), Expect = 2e-05
 Identities = 58/238 (24%), Positives = 97/238 (40%), Gaps = 40/238 (16%)

Query: 2465 ILIFIDDMNMPVSDMY-GAQPPLELIRQLLDLGGVYDTEKNTWKNIQDLSIVAACVPVVN 2523
            +L  ++D+++  SD     QP LE +RQ +D G VY       + +Q      A V V  
Sbjct: 2450 LLFLLEDLHLATSDPEKSCQPVLETLRQAMD-GTVYAHSTLELQTLQPTVNFLATVTVPG 2508

Query: 2524 ----DISPRLLKHFSMLVLPHPSQDILCTIFQAHLGIYFSINNFTPEVQKSKDQ---IIS 2576
                 + PRL + F++L L   +Q    T+ + H+ I  +     P V++ +     ++ 
Sbjct: 2509 YCERPLCPRLFRLFTVLALESMTQ---ATLLERHVPIIQAWLERFPSVERERALARGLVR 2565

Query: 2577 CSLAIYHQVRQNMLPTPTKCHYMFNLRDMFKLL--------------------------- 2609
             S+  +  V    +P+P   HY F+L  +  LL                           
Sbjct: 2566 ASVEAWEAVCNCFMPSPLHPHYHFSLHSVSHLLSSLQLLPNRTGSRGFVDYPNHQEHLRR 2625

Query: 2610 -LGLLQADRTVVNSKEMAALLFVHEATRVFHDRLIDFTDKSLFYRLLSRELENCFQIG 2666
              GL     TV+ +      L++HEA R F DRL    ++S   +LL    ++ F  G
Sbjct: 2626 VSGLRGTCLTVMMATRNVVRLWLHEAQRTFCDRLDSPRERSYCAKLLLVVAQSVFCCG 2683



 Score = 40.4 bits (93), Expect = 0.040
 Identities = 60/281 (21%), Positives = 106/281 (37%), Gaps = 46/281 (16%)

Query: 183 SPKSLYNPYDLQVVSAHTAKHCKEFWVITASFISKVINIVGSVKEVELIPTLEWLSERRH 242
           +P   + PY L VV         E ++ +   I  V  + GS    E +    W     H
Sbjct: 301 APSRYFRPYSLMVVPPDKVN--PEHYIFSPFGILHVHPVEGS----ETMTLGTW---HHH 351

Query: 243 YYLLRQFKIFSDFR---MNKAFVTWKLNVKRIKTEKSRSFLYHHLFLADDLFQTCLVYIR 299
             L +Q +    F+   + K+F  WK NV+     + + FL +HL LA   F   L++I 
Sbjct: 352 CVLWQQLQFIPFFKYCLLRKSFTCWKKNVRLQGLHRLQKFLENHLLLAVPHFGAGLLHIS 411

Query: 300 GLCEDAINLKNYNDHENNLSAICLVKLDSSRTYSLDEFCEEQLQQATQALKQLEDIRNKA 359
            L ++             L ++  +  +  R Y L +      ++  +AL+ L    N  
Sbjct: 412 RLLQE-------------LHSVSWLPQELDRCYELLDLQTALAEEKHKALRLLHRCLNLC 458

Query: 360 ISEMKSTFLKVAEKNEIKEYFESKLSEDD-------------TTHFKLPKYRRLLETFF- 405
            S ++   L   +   +++  + ++   D               H +L +  +  E ++ 
Sbjct: 459 TSILR---LVHEDTYHMQQCLQERVQNCDRIRTGQGSIYLQRVQHKQLEQKLKQAEAWWL 515

Query: 406 ---KFVMLVDY-IFQELIRQLMNTAVTLLLELFNGSAGMPF 442
              KF  LVDY I Q LI  L     + +  +       PF
Sbjct: 516 QLGKFARLVDYMICQSLISVLEEQITSFVANILQAPRQKPF 556


>gi|24415404 MDN1, midasin homolog [Homo sapiens]
          Length = 5596

 Score = 43.9 bits (102), Expect = 0.004
 Identities = 76/346 (21%), Positives = 146/346 (42%), Gaps = 76/346 (21%)

Query: 1548 GPAGTGKTETVKDLAKSLGKHCVVFNCFEDLDY-------------KIVRK--FFFGLVQ 1592
            G    GKT  ++ LA + G HCV  N  E  D              K+V K       ++
Sbjct: 1084 GETSVGKTSLIQWLAAATGNHCVRINNHEHTDIQEYIGCYTSDSSGKLVFKEGVLIDAMR 1143

Query: 1593 SGAWSCFDEFNLIDLEVLSVIASQILTIKAAKDNYSARFVLEGKE-IRINMSCAVFITMN 1651
             G W   DE NL   +VL  +   +       D+     V E +E ++ +    +F T N
Sbjct: 1144 KGYWIILDELNLAPTDVLEALNRLL-------DDNRELLVTETQEVVKAHPRFMLFATQN 1196

Query: 1652 P--RYGGGV----------------ELPDN-LKSLFRPVAMMVPHY-QMIAEIILFSFGF 1691
            P   YGG                  ELP + L+++      + P Y   + +++L    +
Sbjct: 1197 PPGLYGGRKVLSRAFRNRFVELHFDELPSSELETILHKRCSLPPSYCSKLVKVMLDLQSY 1256

Query: 1692 KSANSL-SGK-----LTNLYELA-RKQLSQQDHYNFG-LRSLKI--VLIMAGTKKREFKC 1741
            + ++S+ +GK     L +L+  A R +L++     +  L+ L     +++AG  +++   
Sbjct: 1257 RRSSSVFAGKQGFITLRDLFRWAERYRLAEPTEKEYDWLQHLANDGYMLLAGRVRKQ--- 1313

Query: 1742 LSEADETLIVIEAIREASLPKCPPEDVPLFENI---IGDIFPEVTVLKVNQLALEKVIYT 1798
                +E  ++ E + +    K  P+ +   EN+   +G +  +++ L+ N      +++T
Sbjct: 1314 ----EEIDVIQEVLEKHFKKKLCPQSLFSKENVLKLLGKLSTQISTLECN---FGHIVWT 1366

Query: 1799 ATQQLGLQNWSSQKEKIIQFYNQLQVCVGVMLVGPTGGGKTTVRRI 1844
                 G++  +    + ++F         V+LVG TG GKTT+ ++
Sbjct: 1367 E----GMRRLAMLVGRALEFGEP------VLLVGDTGCGKTTICQV 1402



 Score = 33.5 bits (75), Expect = 4.9
 Identities = 16/45 (35%), Positives = 26/45 (57%)

Query: 2305 ECINYTATRDTTCLSFLMSLLLKNSCPVLLTGESGVGKTAAINQM 2349
            E   + ATR ++ L   +++ +    PVLL GE+G GKT+ I  +
Sbjct: 646  EKFTFAATRPSSVLIEQLAVCVSKGEPVLLVGETGTGKTSTIQYL 690


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score = 43.5 bits (101), Expect = 0.005
 Identities = 166/851 (19%), Positives = 321/851 (37%), Gaps = 121/851 (14%)

Query: 2832 IVANSFLKEKVNFENRENLKEKLAPTCVQIHKSMKDLNR------KYFEETGRFYYTTPN 2885
            I+ N  ++EK + +N +NL + L     Q+ K+++ L        K  E+       T +
Sbjct: 509  ILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS 568

Query: 2886 SYLQFMETFAHILRAREEEMQTKRDRFHMGLSTILEATTLVTEMQEELLILGPQVE---- 2941
            S  Q  +  A    AR ++++ +    H    +I E ++ +++++ E   +  ++E    
Sbjct: 569  SLRQRSQISA---EARVKDIEKENKILH---ESIKETSSKLSKIEFEKRQIKKELEHYKE 622

Query: 2942 --QKTKETETLMEKLRKDSQVVEKVQMLVKQDEEIVAEEVRIVEDYAQKTANE---LKSV 2996
              ++ +E E  +  L K++++++K    +K    I  E++  +E    +   E   LK  
Sbjct: 623  KGERAEELENELHHLEKENELLQKKITNLK----ITCEKIEALEQENSELERENRKLKKT 678

Query: 2997 LPAFDKAIVALNALDK----ADVAELRVYTRPPFLVLTVMNAVCILLQKKPNWATAKLLL 3052
            L +F      L +L+K     D   L +      L    M    + L+ K        L 
Sbjct: 679  LDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKE-------LE 731

Query: 3053 SETGFLKKLINLDKDSI--PDKVFVKLKKI--------VTLPDFNPHKISLVSVACCSLC 3102
            SE   LKK + L K S    +++ V  + +         TL + N     L S       
Sbjct: 732  SEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791

Query: 3103 QWVIALNNYHEVQKVVGPKQIQVAEAQNVLKIARQRLAEKQRGLQLVEEHLLFLQAAYKD 3162
            +      N  E++  +  K+++  E +N          EK +     E   L  QA  KD
Sbjct: 792  ENQTLQKNLEELK--ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD 849

Query: 3163 TVAE------------------------------KQLLANRKTMASRRFQCASVLLTVLE 3192
            T  E                              K+L    K +  R       L+T+ E
Sbjct: 850  TTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRE 909

Query: 3193 D---EKTRWQETINQIDNKLEGILGDILLSAACIVYSGILTPEFRQLIVNKWETFCIENG 3249
            D   EK + Q+  N ++ KL   L  I L+   +++    T +  +L+ +K E+   +  
Sbjct: 910  DLVSEKLKTQQMNNDLE-KLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKK-- 966

Query: 3250 ISLSSKFSLIKVMAQKYEISRWHNQGLPHGQYSV-ENAILIKNGQQWPLLIDP----HRQ 3304
             SL  K   I  +  + E S  +NQ L     +V +N   +K  Q    ++        +
Sbjct: 967  -SLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE 1025

Query: 3305 AHKWIRQMEGSRLQKLSIED-------SNYTKKIENAMKTGGSVLLQNLLETLAPGLKAI 3357
             +KW R+ + +  + L ++D       +N T + E          L+     L   + A+
Sbjct: 1026 DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILAL 1085

Query: 3358 LKKDIYQKKGHYFIRVGDAEFEYNSNFRLYLSTEIDNPHFLPSVYNF------VTMINFT 3411
             ++ +  ++ +  ++  +A+ +  ++     ST + N +    +          ++I   
Sbjct: 1086 QRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKER 1145

Query: 3412 VTFQGLQDQLLSTVVTHEVPHLEDQRSKLLESISLDAITLE------ELEEKTL----NL 3461
               + L D L+      E+ H  ++++   ES+     TL+      E+E + L    N 
Sbjct: 1146 EDLKSLYDSLIKDHEKLELLH--ERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQ 1203

Query: 3462 LQKALGSILDDDKIVDTLRKSKMTSNEISKRIEAT-KKAESEIQAIRKNYLPIATRGALL 3520
            L K  G + D +K++   ++  +  N+  + + A  KK   E   +   Y  +     +L
Sbjct: 1204 LLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVL 1263

Query: 3521 YFLVADLTQINYMYQFSLDWFHQVFVSSVVSKSKEQEHSFKREKVSPKEVHEFISISKEP 3580
                      N     +     Q  + +  SK KEQ               E +S  K  
Sbjct: 1264 -----QTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGN 1318

Query: 3581 NLENEKNLLDK 3591
              E  ++LLD+
Sbjct: 1319 LEEENRHLLDQ 1329


>gi|38045919 huntingtin interacting protein 1 [Homo sapiens]
          Length = 1037

 Score = 42.7 bits (99), Expect = 0.008
 Identities = 56/263 (21%), Positives = 112/263 (42%), Gaps = 21/263 (7%)

Query: 722 TEKAKIMSMKISSMGELTSKEFEAILNRFRNYFRHIVNMAIEKRIGIFNVVSLDYQSECL 781
           TEKA+    +I    +   + +  +  ++    ++  ++ + K   +   VS+  Q++  
Sbjct: 447 TEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADL-LRKNAEVTKQVSMARQAQVD 505

Query: 782 LYIDNV-IHMSHTLIQSVIEKKNKNLLEVVESSLQQLECDPTEIEEFLEHFIFLNAIS-- 838
           L  +   +  S   I    ++K +  LEV+ES  Q+L     E++  L+  +  +A S  
Sbjct: 506 LEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQ-VLQGSLETSAQSEA 564

Query: 839 ---SKISKLEKEFLTMSQLYSVAKHHQIHISEEQIAIFQVLLLKFSQLKSSMKLSKINKD 895
              ++ ++LEKE      L S A H +  +S  +  +    L   S  +S  +L+K  + 
Sbjct: 565 NWAAEFAELEKE---RDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRK 621

Query: 896 TAITKFRDNLEACISGLHVDVGNLKAKIRTPLLLCAGTQVSTAMEMIQTLSGEAASLTNK 955
             +   R   E  I         L      PL+ CAG+    A  ++ T++  ++ +   
Sbjct: 622 MLLVGSRKAAEQVIQDA------LNQLEEPPLISCAGS----ADHLLSTVTSISSCIEQL 671

Query: 956 AKAYSHYQDCFSDSQSHMHSVNV 978
            K++S Y  C  D    +HS+ +
Sbjct: 672 EKSWSQYLACPEDISGLLHSITL 694


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score = 42.0 bits (97), Expect = 0.014
 Identities = 167/852 (19%), Positives = 322/852 (37%), Gaps = 122/852 (14%)

Query: 2832 IVANSFLKEKVNFENRENLKEKLAPTCVQIHKSMKDLNR------KYFEETGRFYYTTPN 2885
            I+ N  ++EK + +N +NL + L     Q+ K+++ L        K  E+       T +
Sbjct: 509  ILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS 568

Query: 2886 SYLQFMETFAHILRAREEEMQTKRDRFHMGLSTILEATTLVTEMQEELLILGPQVE---- 2941
            S  Q  +  A    AR ++++ +    H    +I E ++ +++++ E   +  ++E    
Sbjct: 569  SLRQRSQISA---EARVKDIEKENKILH---ESIKETSSKLSKIEFEKRQIKKELEHYKE 622

Query: 2942 --QKTKETETLMEKLRKDSQVVEKVQMLVKQDEEIVAEEVRIVEDYAQKTANE---LKSV 2996
              ++ +E E  +  L K++++++K    +K    I  E++  +E    +   E   LK  
Sbjct: 623  KGERAEELENELHHLEKENELLQKKITNLK----ITCEKIEALEQENSELERENRKLKKT 678

Query: 2997 LPAFDKAIVALNALDK----ADVAELRVYTRPPFLVLTVMNAVCILLQKKPNWATAKLLL 3052
            L +F      L +L+K     D   L +      L    M    + L+ K        L 
Sbjct: 679  LDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKE-------LE 731

Query: 3053 SETGFLKKLINLDKDSI--PDKVFVKLKKI--------VTLPDFNPHKISLVSVACCSLC 3102
            SE   LKK + L K S    +++ V  + +         TL + N     L S       
Sbjct: 732  SEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791

Query: 3103 QWVIALNNYHEVQKVVGPKQIQVAEAQNVLKIARQRLAEKQRGLQLVEEHLLFLQAAYKD 3162
            +      N  E++  +  K+++  E +N          EK +     E   L  QA  KD
Sbjct: 792  ENQTLQKNLEELK--ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD 849

Query: 3163 TVAE------------------------------KQLLANRKTMASRRFQCASVLLTVLE 3192
            T  E                              K+L    K +  R       L+T+ E
Sbjct: 850  TTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRE 909

Query: 3193 D---EKTRWQETINQIDNKLEGILGDILLSAACIVYSGILTPEFR-QLIVNKWETFCIEN 3248
            D   EK + Q+  N ++ KL   L  I L+   +++    T + R +L+ +K E+   + 
Sbjct: 910  DLVSEKLKTQQMNNDLE-KLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKK- 967

Query: 3249 GISLSSKFSLIKVMAQKYEISRWHNQGLPHGQYSV-ENAILIKNGQQWPLLIDP----HR 3303
              SL  K   I  +  + E S  +NQ L     +V +N   +K  Q    ++        
Sbjct: 968  --SLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISG 1025

Query: 3304 QAHKWIRQMEGSRLQKLSIED-------SNYTKKIENAMKTGGSVLLQNLLETLAPGLKA 3356
            + +KW R+ + +  + L ++D       +N T + E          L+     L   + A
Sbjct: 1026 EDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILA 1085

Query: 3357 ILKKDIYQKKGHYFIRVGDAEFEYNSNFRLYLSTEIDNPHFLPSVYNF------VTMINF 3410
            + ++ +  ++ +  ++  +A+ +  ++     ST + N +    +          ++I  
Sbjct: 1086 LQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKE 1145

Query: 3411 TVTFQGLQDQLLSTVVTHEVPHLEDQRSKLLESISLDAITLE------ELEEKTL----N 3460
                + L D L+      E+ H  ++++   ES+     TL+      E+E + L    N
Sbjct: 1146 REDLKSLYDSLIKDHEKLELLH--ERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYN 1203

Query: 3461 LLQKALGSILDDDKIVDTLRKSKMTSNEISKRIEAT-KKAESEIQAIRKNYLPIATRGAL 3519
             L K  G + D +K++   ++  +  N+  + + A  KK   E   +   Y  +     +
Sbjct: 1204 QLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEV 1263

Query: 3520 LYFLVADLTQINYMYQFSLDWFHQVFVSSVVSKSKEQEHSFKREKVSPKEVHEFISISKE 3579
            L          N     +     Q  + +  SK KEQ               E +S  K 
Sbjct: 1264 L-----QTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKG 1318

Query: 3580 PNLENEKNLLDK 3591
               E  ++LLD+
Sbjct: 1319 NLEEENRHLLDQ 1330


>gi|114155142 nuclear pore complex-associated protein TPR [Homo
            sapiens]
          Length = 2363

 Score = 42.0 bits (97), Expect = 0.014
 Identities = 83/410 (20%), Positives = 162/410 (39%), Gaps = 79/410 (19%)

Query: 2898 LRAREEEMQTKRDRFHMGLSTILEATTLVTEMQEELLILGPQVEQKTKETET-LMEKLRK 2956
            LR  EE++   ++R     S + +   +VT ++E L       E+  K  E  L E    
Sbjct: 941  LRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEF 1000

Query: 2957 DSQVVEKVQMLVKQDEEIVAEEVRIVEDYAQKTANELKSVLPAF---------------- 3000
             +Q+ +K+  + K+ +E+  ++ R +E   Q+ + ELK  L +                 
Sbjct: 1001 QTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLS-ELKKTLSSVQNEVQEALQRASTALS 1059

Query: 3001 ----------DKAIVALNALDK---------ADVAELRVYTRP--------PFLVLTVMN 3033
                      ++A +A+ A +K         ADV  L+               L  T   
Sbjct: 1060 NEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQK 1119

Query: 3034 AVCILLQKKPNWATAKLLLSETGFL-----------KKLINLDKDSIPDKVFVKLKKIVT 3082
            A   LL+ K +W   + +L +                +L++   + + DKV   +K+ V 
Sbjct: 1120 AESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQ 1179

Query: 3083 LPDFNPHKISLVSVACCSLCQWVIALNNYHEVQKVVGPKQIQVAEAQNVLKIARQRLAEK 3142
                 P  +SL         + ++ +  +   +K +   + +VA+ +++    RQR+   
Sbjct: 1180 ----GPLNVSLSEEGKSQ--EQILEILRFIRREKEIAETRFEVAQVESLRY--RQRVELL 1231

Query: 3143 QRGLQLVEEHLLF----LQAAYKDTVAEKQLLANRKTMASRRFQCASVLLTVLEDEKTRW 3198
            +R LQ +++ L      +Q   K     ++L+   +TM             +L +EK R 
Sbjct: 1232 ERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETM-----NVVMETNKMLREEKERL 1286

Query: 3199 QETINQIDNKLEGILGDIL----LSAACIVYSGILTPEFRQL--IVNKWE 3242
            ++ + Q+  K+  +  DIL     +A     SG+L  E + L   V +W+
Sbjct: 1287 EQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWK 1336



 Score = 33.5 bits (75), Expect = 4.9
 Identities = 55/241 (22%), Positives = 101/241 (41%), Gaps = 32/241 (13%)

Query: 805  NLLEVVESSLQQLECDPTEIEEFLEHFIFLNAISSKISKLEKEFLTMSQLYSVAKHHQIH 864
            +LLEV E S  Q+E      +E LE          KI +LEKE    + L S  K     
Sbjct: 327  HLLEV-EQSKDQME------KEMLE----------KIGRLEKELENANDLLSATKRKGAI 369

Query: 865  ISEEQIAIFQVLLLKFSQL-KSSMKLSKINK---DTAITKFRDNLEACISGLHVDVGNLK 920
            +SEE++A         +++ K  MKL+++     +T      + LE      ++D    +
Sbjct: 370  LSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKE 429

Query: 921  AKIRTPLLLCAGTQVSTAMEMIQTLSGEAASLTNKAKAYSHYQDCFSDSQSHMHSVNVEE 980
             + + P+L     +   A + + +LS     L    K     Q+     +++  S  +E 
Sbjct: 430  VEAKAPILKRQREEYERAQKAVASLS---VKLEQAMKEIQRLQE--DTDKANKQSSVLER 484

Query: 981  ITQIVLSEISDIEGDLTLRKKLWEAQEEWKRASWEWRNSSLQSIDVESVQRNVSKLMHII 1040
              + +  ++ D+     +R  L E +E   R +   R+  + S D+ S    +S+  H++
Sbjct: 485  DNRRMEIQVKDLSQQ--IRVLLMELEE--ARGNHVIRDEEVSSADISSSSEVISQ--HLV 538

Query: 1041 S 1041
            S
Sbjct: 539  S 539


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score = 41.6 bits (96), Expect = 0.018
 Identities = 68/278 (24%), Positives = 116/278 (41%), Gaps = 37/278 (13%)

Query: 2746 IPDLFENVELDSIAMKIRYLTEQSGHMDNRQSLLSFFQKRI--YKNLH-IFVIMSPE-GP 2801
            I +L E    DS   K+  + E  G  +  ++L    Q+ I  Y++L  I  I+  E G 
Sbjct: 437  ISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGE 496

Query: 2802 SFRQNCRVYPSMISSCTIDWYERWPEEALLIVANSFLKEKVNFENRENLK----EKLAPT 2857
            S  +  + + SM      D +E   +          L E VN    EN K    ++L P 
Sbjct: 497  SAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPE 556

Query: 2858 CVQIHKSMKDLNRKYF-----------EETGRFYYTTPNSYLQFMETFAHILRAREEEMQ 2906
                 K++++ N  Y            E  G+      NS  +  + F + L+   EEM 
Sbjct: 557  LENTIKNLQEKNGVYLLSLSQRDTMLKELEGKI-----NSLTEEKDDFINKLKNSHEEM- 610

Query: 2907 TKRDRFHMGLSTILEATTLVTEMQEELLILGPQVEQKTKET-----ETLMEKLRKDSQVV 2961
               D FH            + +  E+ +    ++EQK  E      ETL EK + D Q +
Sbjct: 611  ---DNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQND-QKL 666

Query: 2962 EKVQMLVK---QDEEIVAEEVRIVEDYAQKTANELKSV 2996
            EK+ + +K   +D+E+++ EV+ + +   K ++E K +
Sbjct: 667  EKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQL 704


>gi|118498356 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score = 40.4 bits (93), Expect = 0.040
 Identities = 122/572 (21%), Positives = 226/572 (39%), Gaps = 109/572 (19%)

Query: 798  VIEKKNKNLLEVVESSLQQLECDPTEIEEFLEHFIF--------LNAISSKISKLEKEFL 849
            V E+ NK+++E +E  +Q+ +     +EE LE  +         LNAI ++ S L KE  
Sbjct: 721  VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEV- 779

Query: 850  TMSQLYSVAKHHQIHISEEQIAIFQVLLLKFSQLKSSMKL--SKINKDTAITKFRDNLEA 907
               Q     ++ Q+  +     + +V+  K  ++KS  +L  +++ K     K   +L+ 
Sbjct: 780  ---QDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQ 836

Query: 908  CISGLHVDVGNLKAKIRTPLLLCAGTQVSTAMEMIQTLSGE-------AASLTNKAKAYS 960
             I  L  ++GN++ +    L +      S   E+   L G+        A L  K K  +
Sbjct: 837  EIKALKEEIGNVQLEKAQQLSI-----TSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLA 891

Query: 961  HYQDCFSDSQSHMHSV--NVEEITQIVLSEISDIEGDLTLRKKLWEAQEEWKR--ASWEW 1016
            +      D Q    S+  +V+E+ Q  L E S       L   L E + E KR  A  + 
Sbjct: 892  NTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKE 951

Query: 1017 RNSSLQS-----IDVES------------VQRNV---------SKLMHIISVLEKGLPKS 1050
            R S L S      DV+              Q+N           +L+ +IS  EK +   
Sbjct: 952  RESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGL 1011

Query: 1051 -DMVTHLKQVVTEFKQELPIIIALGNPCLKPRHWEALQEIIGKSVPLDKNCKVENLLALK 1109
             + +  LK  V   +++        N  L+ ++WEA++ +             E +L  K
Sbjct: 1012 WNELDSLKDAVEHQRKK--------NNDLREKNWEAMEAL----------ASTEKMLQDK 1053

Query: 1110 MFQYENEINDMSTSATNEA-ALEKMLFKIIDFWNTTPLPLILHHTEIYSIFIIPSIDDIS 1168
            + +   E      +   EA  + K LF  +   +       LH  E              
Sbjct: 1054 VNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFE-------------- 1099

Query: 1169 AQLEESQVILATIKGSPHIGPIKDLVNEWDQNLTLFSYTLEEWMNCQRNWLYLEPVFHSS 1228
               ++++  +A   GS  +  ++  + E D+  TL        + C++   Y   +  + 
Sbjct: 1100 ---KKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQ------LECEK---YKSVLAETE 1147

Query: 1229 EIRRQLPAETELFSQVISMWKKIMSKIQN--KQNALQITTSAGVLEILQNCNIHLEHIKK 1286
             I ++L    E   Q  + WK  + +     KQ     T+S   LE L++ N  +E++++
Sbjct: 1148 GILQKLQRSVE---QEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRR 1204

Query: 1287 SLEDY-LEVKRLIFPRFYFLSNA-ELLDILAD 1316
              E   +E+++    R  +++   EL D+L +
Sbjct: 1205 EREHLEMELEKAEMERSTYVTEVRELKDLLTE 1236


>gi|33620775 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score = 40.4 bits (93), Expect = 0.040
 Identities = 122/572 (21%), Positives = 226/572 (39%), Gaps = 109/572 (19%)

Query: 798  VIEKKNKNLLEVVESSLQQLECDPTEIEEFLEHFIF--------LNAISSKISKLEKEFL 849
            V E+ NK+++E +E  +Q+ +     +EE LE  +         LNAI ++ S L KE  
Sbjct: 721  VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEV- 779

Query: 850  TMSQLYSVAKHHQIHISEEQIAIFQVLLLKFSQLKSSMKL--SKINKDTAITKFRDNLEA 907
               Q     ++ Q+  +     + +V+  K  ++KS  +L  +++ K     K   +L+ 
Sbjct: 780  ---QDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQ 836

Query: 908  CISGLHVDVGNLKAKIRTPLLLCAGTQVSTAMEMIQTLSGE-------AASLTNKAKAYS 960
             I  L  ++GN++ +    L +      S   E+   L G+        A L  K K  +
Sbjct: 837  EIKALKEEIGNVQLEKAQQLSI-----TSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLA 891

Query: 961  HYQDCFSDSQSHMHSV--NVEEITQIVLSEISDIEGDLTLRKKLWEAQEEWKR--ASWEW 1016
            +      D Q    S+  +V+E+ Q  L E S       L   L E + E KR  A  + 
Sbjct: 892  NTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKE 951

Query: 1017 RNSSLQS-----IDVES------------VQRNV---------SKLMHIISVLEKGLPKS 1050
            R S L S      DV+              Q+N           +L+ +IS  EK +   
Sbjct: 952  RESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGL 1011

Query: 1051 -DMVTHLKQVVTEFKQELPIIIALGNPCLKPRHWEALQEIIGKSVPLDKNCKVENLLALK 1109
             + +  LK  V   +++        N  L+ ++WEA++ +             E +L  K
Sbjct: 1012 WNELDSLKDAVEHQRKK--------NNDLREKNWEAMEAL----------ASTEKMLQDK 1053

Query: 1110 MFQYENEINDMSTSATNEA-ALEKMLFKIIDFWNTTPLPLILHHTEIYSIFIIPSIDDIS 1168
            + +   E      +   EA  + K LF  +   +       LH  E              
Sbjct: 1054 VNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFE-------------- 1099

Query: 1169 AQLEESQVILATIKGSPHIGPIKDLVNEWDQNLTLFSYTLEEWMNCQRNWLYLEPVFHSS 1228
               ++++  +A   GS  +  ++  + E D+  TL        + C++   Y   +  + 
Sbjct: 1100 ---KKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQ------LECEK---YKSVLAETE 1147

Query: 1229 EIRRQLPAETELFSQVISMWKKIMSKIQN--KQNALQITTSAGVLEILQNCNIHLEHIKK 1286
             I ++L    E   Q  + WK  + +     KQ     T+S   LE L++ N  +E++++
Sbjct: 1148 GILQKLQRSVE---QEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRR 1204

Query: 1287 SLEDY-LEVKRLIFPRFYFLSNA-ELLDILAD 1316
              E   +E+++    R  +++   EL D+L +
Sbjct: 1205 EREHLEMELEKAEMERSTYVTEVRELKDLLTE 1236


>gi|222144247 dynein heavy chain domain 1 isoform 2 [Homo sapiens]
          Length = 597

 Score = 40.4 bits (93), Expect = 0.040
 Identities = 60/281 (21%), Positives = 106/281 (37%), Gaps = 46/281 (16%)

Query: 183 SPKSLYNPYDLQVVSAHTAKHCKEFWVITASFISKVINIVGSVKEVELIPTLEWLSERRH 242
           +P   + PY L VV         E ++ +   I  V  + GS    E +    W     H
Sbjct: 301 APSRYFRPYSLMVVPPDKVN--PEHYIFSPFGILHVHPVEGS----ETMTLGTW---HHH 351

Query: 243 YYLLRQFKIFSDFR---MNKAFVTWKLNVKRIKTEKSRSFLYHHLFLADDLFQTCLVYIR 299
             L +Q +    F+   + K+F  WK NV+     + + FL +HL LA   F   L++I 
Sbjct: 352 CVLWQQLQFIPFFKYCLLRKSFTCWKKNVRLQGLHRLQKFLENHLLLAVPHFGAGLLHIS 411

Query: 300 GLCEDAINLKNYNDHENNLSAICLVKLDSSRTYSLDEFCEEQLQQATQALKQLEDIRNKA 359
            L ++             L ++  +  +  R Y L +      ++  +AL+ L    N  
Sbjct: 412 RLLQE-------------LHSVSWLPQELDRCYELLDLQTALAEEKHKALRLLHRCLNLC 458

Query: 360 ISEMKSTFLKVAEKNEIKEYFESKLSEDD-------------TTHFKLPKYRRLLETFF- 405
            S ++   L   +   +++  + ++   D               H +L +  +  E ++ 
Sbjct: 459 TSILR---LVHEDTYHMQQCLQERVQNCDRIRTGQGSIYLQRVQHKQLEQKLKQAEAWWL 515

Query: 406 ---KFVMLVDY-IFQELIRQLMNTAVTLLLELFNGSAGMPF 442
              KF  LVDY I Q LI  L     + +  +       PF
Sbjct: 516 QLGKFARLVDYMICQSLISVLEEQITSFVANILQAPRQKPF 556


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 160,218,748
Number of Sequences: 37866
Number of extensions: 7003596
Number of successful extensions: 23526
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 93
Number of HSP's that attempted gapping in prelim test: 22362
Number of HSP's gapped (non-prelim): 963
length of query: 4515
length of database: 18,247,518
effective HSP length: 123
effective length of query: 4392
effective length of database: 13,590,000
effective search space: 59687280000
effective search space used: 59687280000
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 73 (32.7 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.