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Search of human proteins with 222446647
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222446647 coiled-coil domain containing 153 [Homo sapiens]
(210 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222446647 coiled-coil domain containing 153 [Homo sapiens] 412 e-116
gi|32484977 angiomotin like 2 [Homo sapiens] 53 2e-07
gi|126723390 ankyrin repeat domain 24 [Homo sapiens] 52 5e-07
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 51 8e-07
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 51 8e-07
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 51 8e-07
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 51 8e-07
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 51 8e-07
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 51 8e-07
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 51 8e-07
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 51 8e-07
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 51 8e-07
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 49 3e-06
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 49 3e-06
gi|110611218 ribosome binding protein 1 [Homo sapiens] 49 4e-06
gi|110611220 ribosome binding protein 1 [Homo sapiens] 49 4e-06
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 49 4e-06
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 48 5e-06
gi|214010165 rab11-family interacting protein 3 isoform 2 [Homo ... 48 7e-06
gi|7662234 rab11-family interacting protein 3 isoform 1 [Homo sa... 48 7e-06
gi|187607364 tuftelin 1 isoform 2 [Homo sapiens] 47 9e-06
gi|9910596 tuftelin 1 isoform 1 [Homo sapiens] 47 9e-06
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 47 1e-05
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 47 2e-05
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 47 2e-05
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 46 2e-05
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 45 4e-05
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 45 4e-05
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 45 4e-05
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 45 4e-05
>gi|222446647 coiled-coil domain containing 153 [Homo sapiens]
Length = 210
Score = 412 bits (1060), Expect = e-116
Identities = 210/210 (100%), Positives = 210/210 (100%)
Query: 1 MPPKNKEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASED 60
MPPKNKEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASED
Sbjct: 1 MPPKNKEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASED 60
Query: 61 QLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQ 120
QLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQ
Sbjct: 61 QLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQ 120
Query: 121 REAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQWDGA 180
REAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQWDGA
Sbjct: 121 REAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQWDGA 180
Query: 181 ALRLHARHKEQQRQFGLTPPGSLRPPAPSL 210
ALRLHARHKEQQRQFGLTPPGSLRPPAPSL
Sbjct: 181 ALRLHARHKEQQRQFGLTPPGSLRPPAPSL 210
>gi|32484977 angiomotin like 2 [Homo sapiens]
Length = 780
Score = 52.8 bits (125), Expect = 2e-07
Identities = 50/174 (28%), Positives = 80/174 (45%), Gaps = 15/174 (8%)
Query: 37 EKELLRDHLALRRD-EARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQ 95
++E L + + D E RR + LR+RL+ L E +A +M + A
Sbjct: 368 KREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQS 427
Query: 96 EDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKY 155
+ Q ++LE E+ LRG +E +R A E EQALG A+ + +A
Sbjct: 428 YEQQQEQEKLEREMALLRGAIEDQRRRA----ELLEQALGNAQGRAARAEEELRKKQAYV 483
Query: 156 EEILHDSLDRLLAKLRAIKQQWDGAALRLHARHKE-------QQRQFGLTPPGS 202
E++ + L + L +L+A ++ + LRL R ++ QQRQ G P GS
Sbjct: 484 EKV--ERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAG-APGGS 534
>gi|126723390 ankyrin repeat domain 24 [Homo sapiens]
Length = 1146
Score = 51.6 bits (122), Expect = 5e-07
Identities = 40/140 (28%), Positives = 69/140 (49%), Gaps = 18/140 (12%)
Query: 37 EKELLRDHLALRR---DEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHA 93
E E+LR+ LA R ++ R A A + R + AEL A E + AE+ A
Sbjct: 849 ELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEA 908
Query: 94 LQEDMQTRS--KQLEEEVKGLRGQLEACQREAAAAREEAEQ-------------ALGERD 138
L++ + S ++L+EE LRG+ + ++E A +EA + AL E +
Sbjct: 909 LRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERERVCSVALSEHE 968
Query: 139 QALAQLRAHMADMEAKYEEI 158
+ + L+A++A +E + EE+
Sbjct: 969 RIVGTLQANVAQLEGQLEEL 988
Score = 38.5 bits (88), Expect = 0.004
Identities = 34/107 (31%), Positives = 48/107 (44%), Gaps = 11/107 (10%)
Query: 54 RAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLR 113
R + E+ LRQR + AELE A + +A AE R R + E E G
Sbjct: 728 RIRGLEEALRQREREAAAELEAALGKCEAAEAEAGR----------LRERVREAEGSGAS 777
Query: 114 GQLEACQREAAAAREEAEQALGERDQALAQLRAHMADM-EAKYEEIL 159
G + AA E+A + L +RD L +L A A + EA+ +L
Sbjct: 778 GGGGGDTTQLRAALEQAREDLRDRDSRLRELEAASACLDEARASRLL 824
Score = 37.4 bits (85), Expect = 0.009
Identities = 36/149 (24%), Positives = 61/149 (40%), Gaps = 24/149 (16%)
Query: 68 GVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEE-----------EVKGLRGQL 116
GVEA + G S G ++ + LQ +++TR + LEE E++ G+
Sbjct: 696 GVEATVPGI-SAGPILHPGAAEASEKLQVELETRIRGLEEALRQREREAAAELEAALGKC 754
Query: 117 EACQREAAAAREEAEQALG------------ERDQALAQLRAHMADMEAKYEEILHDSLD 164
EA + EA RE +A G + AL Q R + D +++ E+ S
Sbjct: 755 EAAEAEAGRLRERVREAEGSGASGGGGGDTTQLRAALEQAREDLRDRDSRLRELEAASAC 814
Query: 165 RLLAKLRAIKQQWDGAALRLHARHKEQQR 193
A+ + + + LR +E+ R
Sbjct: 815 LDEARASRLLAEEEARGLRAELAQREEAR 843
Score = 32.3 bits (72), Expect = 0.30
Identities = 37/128 (28%), Positives = 52/128 (40%), Gaps = 12/128 (9%)
Query: 28 ESRHRLVVLEK--ELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYA 85
E+R L L + E LR + + E RR + +LR R +E E+ E + A
Sbjct: 894 EARQGLAELREASEALRQSV-VPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRA 952
Query: 86 EMSRQ--CHALQEDMQTRSKQLEEEVKGLRGQLEACQR-------EAAAAREEAEQALGE 136
E+ R+ C + + L+ V L GQLE R E + EA E
Sbjct: 953 ELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSE 1012
Query: 137 RDQALAQL 144
R A AQL
Sbjct: 1013 RHAAEAQL 1020
Score = 30.0 bits (66), Expect = 1.5
Identities = 30/150 (20%), Positives = 68/150 (45%), Gaps = 8/150 (5%)
Query: 30 RHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGAR-SEGKAIYA--- 85
RH E ++ + E A+A Q+L+G+ E E AR ++ +A A
Sbjct: 991 RHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDK 1050
Query: 86 --EMSRQCHALQEDMQTRSKQLEEEVKGL-RGQLEACQREAAAAREEAEQALGERDQALA 142
E ++ L +++ + L+E+ L ++EA + + +++ ++A + +A
Sbjct: 1051 AKEKDKKITELSKEVFNLKEALKEQPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVA 1110
Query: 143 QLRAHMA-DMEAKYEEILHDSLDRLLAKLR 171
R+H+ ++ + +E + L ++L R
Sbjct: 1111 LYRSHLLYAIQGQMDEDVQRILSQILQMQR 1140
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 50.8 bits (120), Expect = 8e-07
Identities = 49/159 (30%), Positives = 73/159 (45%), Gaps = 19/159 (11%)
Query: 28 ESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEM 87
E R+ +E L L R E + + QL ++L G E ELE AR E +
Sbjct: 805 EGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQ------ 858
Query: 88 SRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEA----------EQALGER 137
RQ AL+ + + + L +E GL QL A +RE EEA E +L E
Sbjct: 859 -RQVEALERAAREK-EALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEV 916
Query: 138 DQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQ 176
+ LAQL A +EA+ + +L + + L +L ++QQ
Sbjct: 917 QRQLAQLEARREQLEAEGQALLL-AKETLTGELAGLRQQ 954
Score = 44.3 bits (103), Expect = 8e-05
Identities = 49/191 (25%), Positives = 88/191 (46%), Gaps = 18/191 (9%)
Query: 18 KKNWGADVVAESRHRL--VVLEKELLRDHLALRRDEARRAKASEDQLR---QRLQGVEAE 72
K++ A + E R L L++++L+ A + +A+A +L +L+ EA
Sbjct: 674 KRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEAS 733
Query: 73 LEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQ 132
L+ + S+ A+ +++ + D+ QLEEE L+G+ ++EA AREE E+
Sbjct: 734 LQDSLSKLSALNESLAQD----KLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQER 789
Query: 133 ALGER-DQALAQ------LRAHMADMEAKYEEI--LHDSLDRLLAKLRAIKQQWDGAALR 183
R +Q +A+ LR EA +++ L +L +L + +Q G
Sbjct: 790 LEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQE 849
Query: 184 LHARHKEQQRQ 194
L +E QRQ
Sbjct: 850 LEQARREAQRQ 860
Score = 43.5 bits (101), Expect = 1e-04
Identities = 47/173 (27%), Positives = 79/173 (45%), Gaps = 11/173 (6%)
Query: 28 ESRHRLVVLEKELLRDHLALRRDE--ARRAKASEDQ--LRQRLQGVEAELEGARSEGKAI 83
E+ + ++L KE L LA R + A + KAS D+ + Q+L E E + + E +A
Sbjct: 931 EAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAA 990
Query: 84 YAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQ 143
+ E LQ + + ++LE E L+ QL+ Q E A E ++ L E AL Q
Sbjct: 991 HEE---DLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQ 1047
Query: 144 LRAH---MADMEAKYEEILHDSLDRLLA-KLRAIKQQWDGAALRLHARHKEQQ 192
R +A+ E + L +S L+ KL + +L + + ++ Q
Sbjct: 1048 ERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQ 1100
Score = 42.0 bits (97), Expect = 4e-04
Identities = 47/206 (22%), Positives = 91/206 (44%), Gaps = 38/206 (18%)
Query: 7 EKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRL 66
EK + ++ +K ++ + +RH L + E+ R + R A++ ++Q R +
Sbjct: 1059 EKQQALSLKESEKTALSEKLMGTRHSLATISLEMER--------QKRDAQSRQEQDRSTV 1110
Query: 67 QGVEAELEGARSEGKAIYAEMSRQCHALQE-----------------DMQTRSKQLEEEV 109
+ +EL R++ + A +++ LQE +++T+ + LE+
Sbjct: 1111 NALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDAR 1170
Query: 110 KGLRGQLEACQ---REAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRL 166
GLR +L Q RE+ RE Q GE ++L + AK E L S + L
Sbjct: 1171 DGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGE--------GAKEREALRRSNEEL 1222
Query: 167 LAKLRAIKQQWDGAALRLHARHKEQQ 192
+ ++ K + + +L+L KEQ+
Sbjct: 1223 RSAVK--KAESERISLKLANEDKEQK 1246
Score = 40.0 bits (92), Expect = 0.001
Identities = 31/124 (25%), Positives = 55/124 (44%), Gaps = 10/124 (8%)
Query: 30 RHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARS-----EGKAIY 84
R L +E+E LR H ++ R A + +L + L G E EL A+ E + +
Sbjct: 1879 RRTLDKVEREKLRSH-----EDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVV 1933
Query: 85 AEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQL 144
E S L+ D Q + +L++EV+ LR +R A Q + ++ ++ L
Sbjct: 1934 LEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTL 1993
Query: 145 RAHM 148
+ +
Sbjct: 1994 KGQL 1997
Score = 38.1 bits (87), Expect = 0.005
Identities = 40/151 (26%), Positives = 70/151 (46%), Gaps = 10/151 (6%)
Query: 37 EKELLRDHLALRRDEARRAKASEDQLRQ-RL------QGVEAELEGARSEGKAIYAEMSR 89
EK L+ EA A+ +++L + RL QG+E L A +A+ ++
Sbjct: 765 EKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPT 824
Query: 90 QCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMA 149
H + +Q + QL ++ G +LE +REA E E+A E+ +ALA+ A +A
Sbjct: 825 LRHE-RSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREK-EALAKEHAGLA 882
Query: 150 DMEAKYEEILHDSLDRLLAKLRAIKQQWDGA 180
++ E +L +LR K+ +G+
Sbjct: 883 -VQLVAAEREGRTLSEEATRLRLEKEALEGS 912
Score = 36.6 bits (83), Expect = 0.016
Identities = 47/182 (25%), Positives = 87/182 (47%), Gaps = 18/182 (9%)
Query: 7 EKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRA----KASEDQ- 61
E + S + ++ A +E R V ++ LAL+ + RR+ +A+ DQ
Sbjct: 1543 EAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQV 1602
Query: 62 --LRQRLQGVEAELEGAR---SEGKAIYAEMSRQCHALQEDM---QTRSKQLEEEVKGLR 113
L + LQ E+EL ++ S+ KA ++ L+E + ++R+ +LE + + L
Sbjct: 1603 ATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLE 1662
Query: 114 GQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAI 173
G+L+ R + RE QAL +R + L+ +AD E K L +++RL L +
Sbjct: 1663 GELQR-SRLGLSDREAQAQALQDR---VDSLQRQVADSEVK-AGTLQLTVERLNGALAKV 1717
Query: 174 KQ 175
++
Sbjct: 1718 EE 1719
Score = 33.5 bits (75), Expect = 0.13
Identities = 52/178 (29%), Positives = 75/178 (42%), Gaps = 23/178 (12%)
Query: 27 AESRHRLVVLEKELLRDHLALRRDEARRAKASE-DQLRQRLQGVEAELEGARSEGKAIYA 85
AES + L E LAL +EAR A E +LR LQ E+E +R E +
Sbjct: 1229 AESERISLKLANEDKEQKLALL-EEARTAVGKEAGELRTGLQ----EVERSRLEARRELQ 1283
Query: 86 EMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEA---EQALGERDQALA 142
E+ RQ L + + +L E+ L+G+L +R +R E Q L + + +L
Sbjct: 1284 ELRRQMKMLDSE----NTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLE 1339
Query: 143 QLRAHMADMEAKYEE---ILHDSLDRLLAKLRAI----KQQWD---GAALRLHARHKE 190
+R + + K +E RLL L KQQ D G L+L A E
Sbjct: 1340 VMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAE 1397
Score = 33.1 bits (74), Expect = 0.18
Identities = 51/188 (27%), Positives = 75/188 (39%), Gaps = 46/188 (24%)
Query: 32 RLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAE-------LEGARSEGKAIY 84
RL ++EL + AL+++ +E + +Q L E+E L G R I
Sbjct: 1030 RLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATIS 1089
Query: 85 AEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLE--ACQREAAAA---------REEAEQA 133
EM RQ + D Q+R +Q V L +L QRE AAA +E+A
Sbjct: 1090 LEMERQ----KRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDL 1145
Query: 134 LGERDQAL-------AQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQWDGAALRLHA 186
+RD L QLR +L D+ D L +L +++ LR
Sbjct: 1146 GKQRDSCLREAEELRTQLR------------LLEDARDGLRRELLEAQRK-----LRESQ 1188
Query: 187 RHKEQQRQ 194
+E QRQ
Sbjct: 1189 EGREVQRQ 1196
Score = 33.1 bits (74), Expect = 0.18
Identities = 43/155 (27%), Positives = 70/155 (45%), Gaps = 20/155 (12%)
Query: 37 EKELLRDHLALRRD---EARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHA 93
++++L++ L R EAR+ +S + Q L+G A+LE R E + Q
Sbjct: 1762 DRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEG-------QLQQ 1814
Query: 94 LQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEA 153
L+E ++ R E E L ++ Q E R ++ LG +ALAQL A ++E
Sbjct: 1815 LREVLRQRQ---EGEAAAL-NTVQKLQDE----RRLLQERLGSLQRALAQLEAEKREVER 1866
Query: 154 KYEEILHD--SLDRLLAKLRAIKQQWDGAALRLHA 186
+ D +L R L K+ K + +RL A
Sbjct: 1867 SALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSA 1901
Score = 32.7 bits (73), Expect = 0.23
Identities = 41/143 (28%), Positives = 61/143 (42%), Gaps = 21/143 (14%)
Query: 41 LRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQ---------- 90
L+ LAL + ++ LRQRL EA LE R E + ++ Q
Sbjct: 1306 LQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERR 1365
Query: 91 -CHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMA 149
+L+E T +QL + +GL +LEA + EAA LG R A A+ RA
Sbjct: 1366 LLGSLEEARGTEKQQL-DHARGLELKLEAARAEAA--------ELGLRLSA-AEGRAQGL 1415
Query: 150 DMEAKYEEILHDSLDRLLAKLRA 172
+ E E+ + + L LR+
Sbjct: 1416 EAELARVEVQRRAAEAQLGGLRS 1438
Score = 32.3 bits (72), Expect = 0.30
Identities = 30/136 (22%), Positives = 56/136 (41%), Gaps = 14/136 (10%)
Query: 6 KEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEAR------RAKASE 59
KE +++ +++ G + R L V +++L R E R A+ +E
Sbjct: 1318 KESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTE 1377
Query: 60 DQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEAC 119
Q +G+E +LE AR+E + +S + R++ LE E+ + Q A
Sbjct: 1378 KQQLDHARGLELKLEAARAEAAELGLRLSA--------AEGRAQGLEAELARVEVQRRAA 1429
Query: 120 QREAAAAREEAEQALG 135
+ + R + LG
Sbjct: 1430 EAQLGGLRSALRRGLG 1445
Score = 31.2 bits (69), Expect = 0.67
Identities = 36/178 (20%), Positives = 77/178 (43%), Gaps = 9/178 (5%)
Query: 27 AESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAE 86
A+ + +L ++ELL A + + + A + + + L E+E + A S ++
Sbjct: 1014 AQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTA 1073
Query: 87 MSRQCHALQEDMQTRSKQLEEEVKGL-------RGQLEACQREAAAAREEAEQALGERDQ 139
+S + + + T S ++E + + R + A E R + E+A Q
Sbjct: 1074 LSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQ 1133
Query: 140 ALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQWDGAALR-LHARHKEQQRQFG 196
+ +L+ D+ + + L ++ + L +LR ++ DG L A+ K ++ Q G
Sbjct: 1134 EVRRLQEQARDLGKQRDSCLREA-EELRTQLRLLEDARDGLRRELLEAQRKLRESQEG 1190
Score = 30.8 bits (68), Expect = 0.87
Identities = 37/165 (22%), Positives = 69/165 (41%), Gaps = 7/165 (4%)
Query: 36 LEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEG---ARSEGKAIYAEMSRQCH 92
LE+ L + L E R +LR++LQ +A A EG+ A++ ++
Sbjct: 118 LEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQ 177
Query: 93 ALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADME 152
+ R +LE+++ G+LE + ++ E AL ++ Q A +A +
Sbjct: 178 GKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEE-QQRSASLAQVN 236
Query: 153 AKYEEILHD--SLDRLLAK-LRAIKQQWDGAALRLHARHKEQQRQ 194
A E L S ++ L++ +R + W L R +R+
Sbjct: 237 AMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRRE 281
Score = 30.8 bits (68), Expect = 0.87
Identities = 28/126 (22%), Positives = 57/126 (45%), Gaps = 10/126 (7%)
Query: 27 AESRHRLVVLEKELLRD--------HLALRRDEARRAKASEDQLRQRLQGVEAELEGARS 78
+ES R + + + LRD H +R E +R +++ + L + + L+ A+
Sbjct: 559 SESERRALEEQLQRLRDKTDGAMQAHEDAQR-EVQRLRSANELLSREKSNLAHSLQVAQQ 617
Query: 79 EGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERD 138
+ + + E + A QE+++ + +LEEE + +RE + + EQ G+R
Sbjct: 618 QAEELRQEREK-LQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRS 676
Query: 139 QALAQL 144
+L
Sbjct: 677 VLAKEL 682
Score = 30.0 bits (66), Expect = 1.5
Identities = 28/105 (26%), Positives = 55/105 (52%), Gaps = 11/105 (10%)
Query: 22 GADV-VAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEG 80
GA++ +AE++ ++ LE +++ + A+ D +Q+L+ ++ E+E RS
Sbjct: 1912 GAELELAEAQRQIQQLEAQVV-----VLEQSHSPAQLEVDAQQQQLE-LQQEVERLRSA- 1964
Query: 81 KAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAA 125
A+ R A + + R + LEE+V L+GQL+ R ++A
Sbjct: 1965 ---QAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSSA 2006
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 50.8 bits (120), Expect = 8e-07
Identities = 57/207 (27%), Positives = 90/207 (43%), Gaps = 26/207 (12%)
Query: 5 NKEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQ 64
N ++ + A+K K+ VAE RL V +E R D A++ +E L++
Sbjct: 2261 NTQRFLQEEAEKMKQ------VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2314
Query: 65 RLQGVEAELEGARSEGKAIYAEMSR-----QCHALQEDMQTRSKQLEEEVKGLRGQLEA- 118
++Q V+ E R + +A + + Q LQED + ++QL EE +G + LEA
Sbjct: 2315 KMQAVQ---EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2371
Query: 119 CQREAAAAREEAEQALGERDQALAQLRAHM-ADMEAKYEEILHDSLDR----------LL 167
QR+ + E L + + AQ RA A K E + + L R L+
Sbjct: 2372 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2431
Query: 168 AKLRAIKQQWDGAALRLHARHKEQQRQ 194
L +QQ D A RL E +R+
Sbjct: 2432 QTLEIQRQQSDHDAERLREAIAELERE 2458
Score = 48.1 bits (113), Expect = 5e-06
Identities = 64/210 (30%), Positives = 97/210 (46%), Gaps = 23/210 (10%)
Query: 14 AQKKKKNWGADVVAESRHRL----VVLEKELLRDHLALRRDEA-----RRAKASEDQLRQ 64
A+++ + W R RL V +K L + +++EA RR KA E +RQ
Sbjct: 1627 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1686
Query: 65 RLQGVEAELEGAR--SEGKAIYAEMSRQCHALQEDMQTRSK--QLEEEVKGLRGQLEACQ 120
R + E ELE R +EG A ++ A QE ++ R++ Q E++ + L +L Q
Sbjct: 1687 R-ELAEQELEKQRQLAEGTA-----QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1740
Query: 121 REAAAA---REEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQW 177
REAAAA R+E E L + + L A A E + S RL A+ ++
Sbjct: 1741 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1800
Query: 178 DGAALRLHARHKEQQRQFGLTPPGSLRPPA 207
+ AA RL A +E +RQ L + R A
Sbjct: 1801 EEAA-RLRALAEEAKRQRQLAEEDAARQRA 1829
Score = 47.8 bits (112), Expect = 7e-06
Identities = 34/152 (22%), Positives = 70/152 (46%), Gaps = 16/152 (10%)
Query: 27 AESRHRLVVLE------KELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEG 80
AE R RL +E ++L H + R AK + ++++ + E A+ +
Sbjct: 1356 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1415
Query: 81 KAIYAEMSRQCHALQEDMQTRSKQ----------LEEEVKGLRGQLEACQREAAAAREEA 130
++I E+ + + + ++Q +++Q +EEE++ +R QLEA +R+ A E
Sbjct: 1416 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1475
Query: 131 EQALGERDQALAQLRAHMADMEAKYEEILHDS 162
+ ++A AQ R + E ++ +S
Sbjct: 1476 QALRARAEEAEAQKRQAQEEAERLRRQVQDES 1507
Score = 43.5 bits (101), Expect = 1e-04
Identities = 51/189 (26%), Positives = 80/189 (42%), Gaps = 31/189 (16%)
Query: 23 ADVVAESRHRLVVLEKELLRDHLA---LRRDEARRAKASEDQLRQRLQGVEAELEGARSE 79
A+ E + L LE+ L+ A LR+ E RA+ + L + EAEL+ R
Sbjct: 1525 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR-- 1582
Query: 80 GKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALG---- 135
A +AE + Q ++ QL EE + Q Q EA AREEAE+ L
Sbjct: 1583 --ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ----QAEAERAREEAERELERWQL 1636
Query: 136 ----------ERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQWDGAALRLH 185
+ ++ Q A+ E + EE ++ R A+ +A++Q+ L
Sbjct: 1637 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR------ELA 1690
Query: 186 ARHKEQQRQ 194
+ E+QRQ
Sbjct: 1691 EQELEKQRQ 1699
Score = 40.4 bits (93), Expect = 0.001
Identities = 36/127 (28%), Positives = 65/127 (51%), Gaps = 15/127 (11%)
Query: 37 EKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQE 96
+++LL + LA + EA A Q+ Q +EAEL R+E + + A +R +E
Sbjct: 1728 QRQLLEEELARLQREAAAAT-------QKRQELEAELAKVRAEMEVLLASKAR----AEE 1776
Query: 97 DMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYE 156
+ ++ S++ ++ ++ G+ EAA R AE+A +R + LA+ A A A+ E
Sbjct: 1777 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA--KRQRQLAEEDA--ARQRAEAE 1832
Query: 157 EILHDSL 163
+L + L
Sbjct: 1833 RVLAEKL 1839
Score = 40.4 bits (93), Expect = 0.001
Identities = 46/174 (26%), Positives = 82/174 (47%), Gaps = 20/174 (11%)
Query: 6 KEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAK--ASEDQLR 63
+E+ ++ ++ +K+ A+ A +R R LE+ + L + +EARR + A ++ R
Sbjct: 1979 EERRRREAEERVQKSLAAEEEA-ARQRKAALEEV---ERLKAKVEEARRLRERAEQESAR 2034
Query: 64 QRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREA 123
Q EA + ++E KA + ++ LQ+ +Q L++ LRG EA
Sbjct: 2035 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ----LRG-------EA 2083
Query: 124 AAAR---EEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIK 174
AAR EEAE+A + ++ AQ R + + E + + R A+ A K
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2137
Score = 38.9 bits (89), Expect = 0.003
Identities = 33/169 (19%), Positives = 83/169 (49%), Gaps = 8/169 (4%)
Query: 15 QKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVE---- 70
Q+++ + A+ + E+ L +++L ++ L+ ++QL Q Q ++
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496
Query: 71 AELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEA 130
+E + + I E ++ Q+++ +++QL EE + + Q+E ++ A+ EEA
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEV-AKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555
Query: 131 EQALGERDQALAQLRAHMADME---AKYEEILHDSLDRLLAKLRAIKQQ 176
+ E ++ + + + + +E + EE+L + RL +L+ +++Q
Sbjct: 2556 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604
Score = 36.6 bits (83), Expect = 0.016
Identities = 47/183 (25%), Positives = 80/183 (43%), Gaps = 27/183 (14%)
Query: 7 EKGKKSGAQKKKKNWGADV-----VAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQ 61
E+ +S ++K K+ A+ +AE RL L +E R +R A ED
Sbjct: 1775 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR----------QRQLAEEDA 1824
Query: 62 LRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQR 121
RQR AE E +E A E +R L+ + + K+ E E + LR E
Sbjct: 1825 ARQR-----AEAERVLAEKLAAIGEATR----LKTEAEIALKEKEAENERLRRLAEDEAF 1875
Query: 122 EAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSL---DRLLAKLRAIKQQWD 178
+ E+A Q + ++ LAQLR + + ++ D+L ++ ++ A+K ++
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1935
Query: 179 GAA 181
AA
Sbjct: 1936 KAA 1938
Score = 36.6 bits (83), Expect = 0.016
Identities = 32/122 (26%), Positives = 53/122 (43%), Gaps = 7/122 (5%)
Query: 30 RHRLVVLEK----ELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYA 85
R R + EK +L +D +A + + + Q+ Q Q + A +E AR
Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2564
Query: 86 EMSRQCHALQEDMQTRSKQ---LEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALA 142
+ R+ LQ+ Q R +Q L EE + LR QL+ + + AA +E+ + A
Sbjct: 2565 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2624
Query: 143 QL 144
L
Sbjct: 2625 TL 2626
Score = 35.8 bits (81), Expect = 0.027
Identities = 35/132 (26%), Positives = 57/132 (43%), Gaps = 20/132 (15%)
Query: 39 ELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKA---IYAEMSRQCHALQ 95
+ + + L +E R A+ + R+RL VEA LE R +A A+ R+ LQ
Sbjct: 1335 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1394
Query: 96 E--------------DMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQAL 141
+ D Q + + ++EE++ LR EA E A +AE A R +
Sbjct: 1395 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA---EIQAKARQAEAAERSRLRIE 1451
Query: 142 AQLRAHMADMEA 153
++R +EA
Sbjct: 1452 EEIRVVRLQLEA 1463
Score = 34.7 bits (78), Expect = 0.060
Identities = 39/155 (25%), Positives = 71/155 (45%), Gaps = 19/155 (12%)
Query: 27 AESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARS-------- 78
A+SR + V E E L+ + +A+A+ ++LR+ EAE E AR
Sbjct: 2105 AQSRRQ--VEEAERLKQSAEEQAQARAQAQAAAEKLRK-----EAEQEAARRAQAEQAAL 2157
Query: 79 -EGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGER 137
+ +A AEM + ++ ++ ++ Q+E+E+ LR QLE + EE ++ E
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKA-QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2216
Query: 138 DQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRA 172
+A Q + E + + L +L A++ A
Sbjct: 2217 TEAARQ--RSQVEEELFSVRVQMEELSKLKARIEA 2249
Score = 28.9 bits (63), Expect = 3.3
Identities = 41/157 (26%), Positives = 67/157 (42%), Gaps = 35/157 (22%)
Query: 58 SEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQ--------CHALQEDMQTRSKQLEEEV 109
+ED LR + Q AELE AR A E R+ A +E+ + K EEV
Sbjct: 1955 AEDTLRSKEQ---AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011
Query: 110 KGLRGQLEACQR-----------EAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEI 158
+ L+ ++E +R + A+E A++ L A+ +AH ++ K +E
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL------QAEEKAHAFAVQQKEQE- 2064
Query: 159 LHDSLDRLLAKLRAIKQQWDG--AALRLHARHKEQQR 193
L + L + +++ Q G A R A E+ R
Sbjct: 2065 ----LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2097
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 50.8 bits (120), Expect = 8e-07
Identities = 57/207 (27%), Positives = 90/207 (43%), Gaps = 26/207 (12%)
Query: 5 NKEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQ 64
N ++ + A+K K+ VAE RL V +E R D A++ +E L++
Sbjct: 2265 NTQRFLQEEAEKMKQ------VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2318
Query: 65 RLQGVEAELEGARSEGKAIYAEMSR-----QCHALQEDMQTRSKQLEEEVKGLRGQLEA- 118
++Q V+ E R + +A + + Q LQED + ++QL EE +G + LEA
Sbjct: 2319 KMQAVQ---EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2375
Query: 119 CQREAAAAREEAEQALGERDQALAQLRAHM-ADMEAKYEEILHDSLDR----------LL 167
QR+ + E L + + AQ RA A K E + + L R L+
Sbjct: 2376 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2435
Query: 168 AKLRAIKQQWDGAALRLHARHKEQQRQ 194
L +QQ D A RL E +R+
Sbjct: 2436 QTLEIQRQQSDHDAERLREAIAELERE 2462
Score = 48.1 bits (113), Expect = 5e-06
Identities = 64/210 (30%), Positives = 97/210 (46%), Gaps = 23/210 (10%)
Query: 14 AQKKKKNWGADVVAESRHRL----VVLEKELLRDHLALRRDEA-----RRAKASEDQLRQ 64
A+++ + W R RL V +K L + +++EA RR KA E +RQ
Sbjct: 1631 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1690
Query: 65 RLQGVEAELEGAR--SEGKAIYAEMSRQCHALQEDMQTRSK--QLEEEVKGLRGQLEACQ 120
R + E ELE R +EG A ++ A QE ++ R++ Q E++ + L +L Q
Sbjct: 1691 R-ELAEQELEKQRQLAEGTA-----QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1744
Query: 121 REAAAA---REEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQW 177
REAAAA R+E E L + + L A A E + S RL A+ ++
Sbjct: 1745 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1804
Query: 178 DGAALRLHARHKEQQRQFGLTPPGSLRPPA 207
+ AA RL A +E +RQ L + R A
Sbjct: 1805 EEAA-RLRALAEEAKRQRQLAEEDAARQRA 1833
Score = 47.8 bits (112), Expect = 7e-06
Identities = 34/152 (22%), Positives = 70/152 (46%), Gaps = 16/152 (10%)
Query: 27 AESRHRLVVLE------KELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEG 80
AE R RL +E ++L H + R AK + ++++ + E A+ +
Sbjct: 1360 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1419
Query: 81 KAIYAEMSRQCHALQEDMQTRSKQ----------LEEEVKGLRGQLEACQREAAAAREEA 130
++I E+ + + + ++Q +++Q +EEE++ +R QLEA +R+ A E
Sbjct: 1420 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1479
Query: 131 EQALGERDQALAQLRAHMADMEAKYEEILHDS 162
+ ++A AQ R + E ++ +S
Sbjct: 1480 QALRARAEEAEAQKRQAQEEAERLRRQVQDES 1511
Score = 43.5 bits (101), Expect = 1e-04
Identities = 51/189 (26%), Positives = 80/189 (42%), Gaps = 31/189 (16%)
Query: 23 ADVVAESRHRLVVLEKELLRDHLA---LRRDEARRAKASEDQLRQRLQGVEAELEGARSE 79
A+ E + L LE+ L+ A LR+ E RA+ + L + EAEL+ R
Sbjct: 1529 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR-- 1586
Query: 80 GKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALG---- 135
A +AE + Q ++ QL EE + Q Q EA AREEAE+ L
Sbjct: 1587 --ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ----QAEAERAREEAERELERWQL 1640
Query: 136 ----------ERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQWDGAALRLH 185
+ ++ Q A+ E + EE ++ R A+ +A++Q+ L
Sbjct: 1641 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR------ELA 1694
Query: 186 ARHKEQQRQ 194
+ E+QRQ
Sbjct: 1695 EQELEKQRQ 1703
Score = 40.4 bits (93), Expect = 0.001
Identities = 36/127 (28%), Positives = 65/127 (51%), Gaps = 15/127 (11%)
Query: 37 EKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQE 96
+++LL + LA + EA A Q+ Q +EAEL R+E + + A +R +E
Sbjct: 1732 QRQLLEEELARLQREAAAAT-------QKRQELEAELAKVRAEMEVLLASKAR----AEE 1780
Query: 97 DMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYE 156
+ ++ S++ ++ ++ G+ EAA R AE+A +R + LA+ A A A+ E
Sbjct: 1781 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA--KRQRQLAEEDA--ARQRAEAE 1836
Query: 157 EILHDSL 163
+L + L
Sbjct: 1837 RVLAEKL 1843
Score = 40.4 bits (93), Expect = 0.001
Identities = 46/174 (26%), Positives = 82/174 (47%), Gaps = 20/174 (11%)
Query: 6 KEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAK--ASEDQLR 63
+E+ ++ ++ +K+ A+ A +R R LE+ + L + +EARR + A ++ R
Sbjct: 1983 EERRRREAEERVQKSLAAEEEA-ARQRKAALEEV---ERLKAKVEEARRLRERAEQESAR 2038
Query: 64 QRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREA 123
Q EA + ++E KA + ++ LQ+ +Q L++ LRG EA
Sbjct: 2039 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ----LRG-------EA 2087
Query: 124 AAAR---EEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIK 174
AAR EEAE+A + ++ AQ R + + E + + R A+ A K
Sbjct: 2088 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2141
Score = 38.9 bits (89), Expect = 0.003
Identities = 33/169 (19%), Positives = 83/169 (49%), Gaps = 8/169 (4%)
Query: 15 QKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVE---- 70
Q+++ + A+ + E+ L +++L ++ L+ ++QL Q Q ++
Sbjct: 2441 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2500
Query: 71 AELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEA 130
+E + + I E ++ Q+++ +++QL EE + + Q+E ++ A+ EEA
Sbjct: 2501 SEKDSLLQRERFIEQEKAKLEQLFQDEV-AKAQQLREEQQRQQQQMEQERQRLVASMEEA 2559
Query: 131 EQALGERDQALAQLRAHMADME---AKYEEILHDSLDRLLAKLRAIKQQ 176
+ E ++ + + + + +E + EE+L + RL +L+ +++Q
Sbjct: 2560 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2608
Score = 36.6 bits (83), Expect = 0.016
Identities = 47/183 (25%), Positives = 80/183 (43%), Gaps = 27/183 (14%)
Query: 7 EKGKKSGAQKKKKNWGADV-----VAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQ 61
E+ +S ++K K+ A+ +AE RL L +E R +R A ED
Sbjct: 1779 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR----------QRQLAEEDA 1828
Query: 62 LRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQR 121
RQR AE E +E A E +R L+ + + K+ E E + LR E
Sbjct: 1829 ARQR-----AEAERVLAEKLAAIGEATR----LKTEAEIALKEKEAENERLRRLAEDEAF 1879
Query: 122 EAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSL---DRLLAKLRAIKQQWD 178
+ E+A Q + ++ LAQLR + + ++ D+L ++ ++ A+K ++
Sbjct: 1880 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1939
Query: 179 GAA 181
AA
Sbjct: 1940 KAA 1942
Score = 36.6 bits (83), Expect = 0.016
Identities = 32/122 (26%), Positives = 53/122 (43%), Gaps = 7/122 (5%)
Query: 30 RHRLVVLEK----ELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYA 85
R R + EK +L +D +A + + + Q+ Q Q + A +E AR
Sbjct: 2509 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2568
Query: 86 EMSRQCHALQEDMQTRSKQ---LEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALA 142
+ R+ LQ+ Q R +Q L EE + LR QL+ + + AA +E+ + A
Sbjct: 2569 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2628
Query: 143 QL 144
L
Sbjct: 2629 TL 2630
Score = 35.8 bits (81), Expect = 0.027
Identities = 35/132 (26%), Positives = 57/132 (43%), Gaps = 20/132 (15%)
Query: 39 ELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKA---IYAEMSRQCHALQ 95
+ + + L +E R A+ + R+RL VEA LE R +A A+ R+ LQ
Sbjct: 1339 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1398
Query: 96 E--------------DMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQAL 141
+ D Q + + ++EE++ LR EA E A +AE A R +
Sbjct: 1399 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA---EIQAKARQAEAAERSRLRIE 1455
Query: 142 AQLRAHMADMEA 153
++R +EA
Sbjct: 1456 EEIRVVRLQLEA 1467
Score = 34.7 bits (78), Expect = 0.060
Identities = 39/155 (25%), Positives = 71/155 (45%), Gaps = 19/155 (12%)
Query: 27 AESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARS-------- 78
A+SR + V E E L+ + +A+A+ ++LR+ EAE E AR
Sbjct: 2109 AQSRRQ--VEEAERLKQSAEEQAQARAQAQAAAEKLRK-----EAEQEAARRAQAEQAAL 2161
Query: 79 -EGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGER 137
+ +A AEM + ++ ++ ++ Q+E+E+ LR QLE + EE ++ E
Sbjct: 2162 RQKQAADAEMEKHKKFAEQTLRQKA-QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2220
Query: 138 DQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRA 172
+A Q + E + + L +L A++ A
Sbjct: 2221 TEAARQ--RSQVEEELFSVRVQMEELSKLKARIEA 2253
Score = 28.9 bits (63), Expect = 3.3
Identities = 41/157 (26%), Positives = 67/157 (42%), Gaps = 35/157 (22%)
Query: 58 SEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQ--------CHALQEDMQTRSKQLEEEV 109
+ED LR + Q AELE AR A E R+ A +E+ + K EEV
Sbjct: 1959 AEDTLRSKEQ---AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2015
Query: 110 KGLRGQLEACQR-----------EAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEI 158
+ L+ ++E +R + A+E A++ L A+ +AH ++ K +E
Sbjct: 2016 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL------QAEEKAHAFAVQQKEQE- 2068
Query: 159 LHDSLDRLLAKLRAIKQQWDG--AALRLHARHKEQQR 193
L + L + +++ Q G A R A E+ R
Sbjct: 2069 ----LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2101
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 50.8 bits (120), Expect = 8e-07
Identities = 57/207 (27%), Positives = 90/207 (43%), Gaps = 26/207 (12%)
Query: 5 NKEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQ 64
N ++ + A+K K+ VAE RL V +E R D A++ +E L++
Sbjct: 2261 NTQRFLQEEAEKMKQ------VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2314
Query: 65 RLQGVEAELEGARSEGKAIYAEMSR-----QCHALQEDMQTRSKQLEEEVKGLRGQLEA- 118
++Q V+ E R + +A + + Q LQED + ++QL EE +G + LEA
Sbjct: 2315 KMQAVQ---EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2371
Query: 119 CQREAAAAREEAEQALGERDQALAQLRAHM-ADMEAKYEEILHDSLDR----------LL 167
QR+ + E L + + AQ RA A K E + + L R L+
Sbjct: 2372 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2431
Query: 168 AKLRAIKQQWDGAALRLHARHKEQQRQ 194
L +QQ D A RL E +R+
Sbjct: 2432 QTLEIQRQQSDHDAERLREAIAELERE 2458
Score = 48.1 bits (113), Expect = 5e-06
Identities = 64/210 (30%), Positives = 97/210 (46%), Gaps = 23/210 (10%)
Query: 14 AQKKKKNWGADVVAESRHRL----VVLEKELLRDHLALRRDEA-----RRAKASEDQLRQ 64
A+++ + W R RL V +K L + +++EA RR KA E +RQ
Sbjct: 1627 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1686
Query: 65 RLQGVEAELEGAR--SEGKAIYAEMSRQCHALQEDMQTRSK--QLEEEVKGLRGQLEACQ 120
R + E ELE R +EG A ++ A QE ++ R++ Q E++ + L +L Q
Sbjct: 1687 R-ELAEQELEKQRQLAEGTA-----QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1740
Query: 121 REAAAA---REEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQW 177
REAAAA R+E E L + + L A A E + S RL A+ ++
Sbjct: 1741 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1800
Query: 178 DGAALRLHARHKEQQRQFGLTPPGSLRPPA 207
+ AA RL A +E +RQ L + R A
Sbjct: 1801 EEAA-RLRALAEEAKRQRQLAEEDAARQRA 1829
Score = 47.8 bits (112), Expect = 7e-06
Identities = 34/152 (22%), Positives = 70/152 (46%), Gaps = 16/152 (10%)
Query: 27 AESRHRLVVLE------KELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEG 80
AE R RL +E ++L H + R AK + ++++ + E A+ +
Sbjct: 1356 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1415
Query: 81 KAIYAEMSRQCHALQEDMQTRSKQ----------LEEEVKGLRGQLEACQREAAAAREEA 130
++I E+ + + + ++Q +++Q +EEE++ +R QLEA +R+ A E
Sbjct: 1416 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1475
Query: 131 EQALGERDQALAQLRAHMADMEAKYEEILHDS 162
+ ++A AQ R + E ++ +S
Sbjct: 1476 QALRARAEEAEAQKRQAQEEAERLRRQVQDES 1507
Score = 43.5 bits (101), Expect = 1e-04
Identities = 51/189 (26%), Positives = 80/189 (42%), Gaps = 31/189 (16%)
Query: 23 ADVVAESRHRLVVLEKELLRDHLA---LRRDEARRAKASEDQLRQRLQGVEAELEGARSE 79
A+ E + L LE+ L+ A LR+ E RA+ + L + EAEL+ R
Sbjct: 1525 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR-- 1582
Query: 80 GKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALG---- 135
A +AE + Q ++ QL EE + Q Q EA AREEAE+ L
Sbjct: 1583 --ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ----QAEAERAREEAERELERWQL 1636
Query: 136 ----------ERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQWDGAALRLH 185
+ ++ Q A+ E + EE ++ R A+ +A++Q+ L
Sbjct: 1637 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR------ELA 1690
Query: 186 ARHKEQQRQ 194
+ E+QRQ
Sbjct: 1691 EQELEKQRQ 1699
Score = 40.4 bits (93), Expect = 0.001
Identities = 36/127 (28%), Positives = 65/127 (51%), Gaps = 15/127 (11%)
Query: 37 EKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQE 96
+++LL + LA + EA A Q+ Q +EAEL R+E + + A +R +E
Sbjct: 1728 QRQLLEEELARLQREAAAAT-------QKRQELEAELAKVRAEMEVLLASKAR----AEE 1776
Query: 97 DMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYE 156
+ ++ S++ ++ ++ G+ EAA R AE+A +R + LA+ A A A+ E
Sbjct: 1777 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA--KRQRQLAEEDA--ARQRAEAE 1832
Query: 157 EILHDSL 163
+L + L
Sbjct: 1833 RVLAEKL 1839
Score = 40.4 bits (93), Expect = 0.001
Identities = 46/174 (26%), Positives = 82/174 (47%), Gaps = 20/174 (11%)
Query: 6 KEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAK--ASEDQLR 63
+E+ ++ ++ +K+ A+ A +R R LE+ + L + +EARR + A ++ R
Sbjct: 1979 EERRRREAEERVQKSLAAEEEA-ARQRKAALEEV---ERLKAKVEEARRLRERAEQESAR 2034
Query: 64 QRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREA 123
Q EA + ++E KA + ++ LQ+ +Q L++ LRG EA
Sbjct: 2035 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ----LRG-------EA 2083
Query: 124 AAAR---EEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIK 174
AAR EEAE+A + ++ AQ R + + E + + R A+ A K
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2137
Score = 38.9 bits (89), Expect = 0.003
Identities = 33/169 (19%), Positives = 83/169 (49%), Gaps = 8/169 (4%)
Query: 15 QKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVE---- 70
Q+++ + A+ + E+ L +++L ++ L+ ++QL Q Q ++
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496
Query: 71 AELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEA 130
+E + + I E ++ Q+++ +++QL EE + + Q+E ++ A+ EEA
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEV-AKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555
Query: 131 EQALGERDQALAQLRAHMADME---AKYEEILHDSLDRLLAKLRAIKQQ 176
+ E ++ + + + + +E + EE+L + RL +L+ +++Q
Sbjct: 2556 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604
Score = 36.6 bits (83), Expect = 0.016
Identities = 47/183 (25%), Positives = 80/183 (43%), Gaps = 27/183 (14%)
Query: 7 EKGKKSGAQKKKKNWGADV-----VAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQ 61
E+ +S ++K K+ A+ +AE RL L +E R +R A ED
Sbjct: 1775 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR----------QRQLAEEDA 1824
Query: 62 LRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQR 121
RQR AE E +E A E +R L+ + + K+ E E + LR E
Sbjct: 1825 ARQR-----AEAERVLAEKLAAIGEATR----LKTEAEIALKEKEAENERLRRLAEDEAF 1875
Query: 122 EAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSL---DRLLAKLRAIKQQWD 178
+ E+A Q + ++ LAQLR + + ++ D+L ++ ++ A+K ++
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1935
Query: 179 GAA 181
AA
Sbjct: 1936 KAA 1938
Score = 36.6 bits (83), Expect = 0.016
Identities = 32/122 (26%), Positives = 53/122 (43%), Gaps = 7/122 (5%)
Query: 30 RHRLVVLEK----ELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYA 85
R R + EK +L +D +A + + + Q+ Q Q + A +E AR
Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2564
Query: 86 EMSRQCHALQEDMQTRSKQ---LEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALA 142
+ R+ LQ+ Q R +Q L EE + LR QL+ + + AA +E+ + A
Sbjct: 2565 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2624
Query: 143 QL 144
L
Sbjct: 2625 TL 2626
Score = 35.8 bits (81), Expect = 0.027
Identities = 35/132 (26%), Positives = 57/132 (43%), Gaps = 20/132 (15%)
Query: 39 ELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKA---IYAEMSRQCHALQ 95
+ + + L +E R A+ + R+RL VEA LE R +A A+ R+ LQ
Sbjct: 1335 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1394
Query: 96 E--------------DMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQAL 141
+ D Q + + ++EE++ LR EA E A +AE A R +
Sbjct: 1395 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA---EIQAKARQAEAAERSRLRIE 1451
Query: 142 AQLRAHMADMEA 153
++R +EA
Sbjct: 1452 EEIRVVRLQLEA 1463
Score = 34.7 bits (78), Expect = 0.060
Identities = 39/155 (25%), Positives = 71/155 (45%), Gaps = 19/155 (12%)
Query: 27 AESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARS-------- 78
A+SR + V E E L+ + +A+A+ ++LR+ EAE E AR
Sbjct: 2105 AQSRRQ--VEEAERLKQSAEEQAQARAQAQAAAEKLRK-----EAEQEAARRAQAEQAAL 2157
Query: 79 -EGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGER 137
+ +A AEM + ++ ++ ++ Q+E+E+ LR QLE + EE ++ E
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKA-QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2216
Query: 138 DQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRA 172
+A Q + E + + L +L A++ A
Sbjct: 2217 TEAARQ--RSQVEEELFSVRVQMEELSKLKARIEA 2249
Score = 28.9 bits (63), Expect = 3.3
Identities = 41/157 (26%), Positives = 67/157 (42%), Gaps = 35/157 (22%)
Query: 58 SEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQ--------CHALQEDMQTRSKQLEEEV 109
+ED LR + Q AELE AR A E R+ A +E+ + K EEV
Sbjct: 1955 AEDTLRSKEQ---AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011
Query: 110 KGLRGQLEACQR-----------EAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEI 158
+ L+ ++E +R + A+E A++ L A+ +AH ++ K +E
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL------QAEEKAHAFAVQQKEQE- 2064
Query: 159 LHDSLDRLLAKLRAIKQQWDG--AALRLHARHKEQQR 193
L + L + +++ Q G A R A E+ R
Sbjct: 2065 ----LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2097
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 50.8 bits (120), Expect = 8e-07
Identities = 57/207 (27%), Positives = 90/207 (43%), Gaps = 26/207 (12%)
Query: 5 NKEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQ 64
N ++ + A+K K+ VAE RL V +E R D A++ +E L++
Sbjct: 2229 NTQRFLQEEAEKMKQ------VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2282
Query: 65 RLQGVEAELEGARSEGKAIYAEMSR-----QCHALQEDMQTRSKQLEEEVKGLRGQLEA- 118
++Q V+ E R + +A + + Q LQED + ++QL EE +G + LEA
Sbjct: 2283 KMQAVQ---EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2339
Query: 119 CQREAAAAREEAEQALGERDQALAQLRAHM-ADMEAKYEEILHDSLDR----------LL 167
QR+ + E L + + AQ RA A K E + + L R L+
Sbjct: 2340 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2399
Query: 168 AKLRAIKQQWDGAALRLHARHKEQQRQ 194
L +QQ D A RL E +R+
Sbjct: 2400 QTLEIQRQQSDHDAERLREAIAELERE 2426
Score = 48.1 bits (113), Expect = 5e-06
Identities = 64/210 (30%), Positives = 97/210 (46%), Gaps = 23/210 (10%)
Query: 14 AQKKKKNWGADVVAESRHRL----VVLEKELLRDHLALRRDEA-----RRAKASEDQLRQ 64
A+++ + W R RL V +K L + +++EA RR KA E +RQ
Sbjct: 1595 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1654
Query: 65 RLQGVEAELEGAR--SEGKAIYAEMSRQCHALQEDMQTRSK--QLEEEVKGLRGQLEACQ 120
R + E ELE R +EG A ++ A QE ++ R++ Q E++ + L +L Q
Sbjct: 1655 R-ELAEQELEKQRQLAEGTA-----QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1708
Query: 121 REAAAA---REEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQW 177
REAAAA R+E E L + + L A A E + S RL A+ ++
Sbjct: 1709 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1768
Query: 178 DGAALRLHARHKEQQRQFGLTPPGSLRPPA 207
+ AA RL A +E +RQ L + R A
Sbjct: 1769 EEAA-RLRALAEEAKRQRQLAEEDAARQRA 1797
Score = 47.8 bits (112), Expect = 7e-06
Identities = 34/152 (22%), Positives = 70/152 (46%), Gaps = 16/152 (10%)
Query: 27 AESRHRLVVLE------KELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEG 80
AE R RL +E ++L H + R AK + ++++ + E A+ +
Sbjct: 1324 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1383
Query: 81 KAIYAEMSRQCHALQEDMQTRSKQ----------LEEEVKGLRGQLEACQREAAAAREEA 130
++I E+ + + + ++Q +++Q +EEE++ +R QLEA +R+ A E
Sbjct: 1384 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1443
Query: 131 EQALGERDQALAQLRAHMADMEAKYEEILHDS 162
+ ++A AQ R + E ++ +S
Sbjct: 1444 QALRARAEEAEAQKRQAQEEAERLRRQVQDES 1475
Score = 43.5 bits (101), Expect = 1e-04
Identities = 51/189 (26%), Positives = 80/189 (42%), Gaps = 31/189 (16%)
Query: 23 ADVVAESRHRLVVLEKELLRDHLA---LRRDEARRAKASEDQLRQRLQGVEAELEGARSE 79
A+ E + L LE+ L+ A LR+ E RA+ + L + EAEL+ R
Sbjct: 1493 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR-- 1550
Query: 80 GKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALG---- 135
A +AE + Q ++ QL EE + Q Q EA AREEAE+ L
Sbjct: 1551 --ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ----QAEAERAREEAERELERWQL 1604
Query: 136 ----------ERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQWDGAALRLH 185
+ ++ Q A+ E + EE ++ R A+ +A++Q+ L
Sbjct: 1605 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR------ELA 1658
Query: 186 ARHKEQQRQ 194
+ E+QRQ
Sbjct: 1659 EQELEKQRQ 1667
Score = 40.4 bits (93), Expect = 0.001
Identities = 36/127 (28%), Positives = 65/127 (51%), Gaps = 15/127 (11%)
Query: 37 EKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQE 96
+++LL + LA + EA A Q+ Q +EAEL R+E + + A +R +E
Sbjct: 1696 QRQLLEEELARLQREAAAAT-------QKRQELEAELAKVRAEMEVLLASKAR----AEE 1744
Query: 97 DMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYE 156
+ ++ S++ ++ ++ G+ EAA R AE+A +R + LA+ A A A+ E
Sbjct: 1745 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA--KRQRQLAEEDA--ARQRAEAE 1800
Query: 157 EILHDSL 163
+L + L
Sbjct: 1801 RVLAEKL 1807
Score = 40.4 bits (93), Expect = 0.001
Identities = 46/174 (26%), Positives = 82/174 (47%), Gaps = 20/174 (11%)
Query: 6 KEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAK--ASEDQLR 63
+E+ ++ ++ +K+ A+ A +R R LE+ + L + +EARR + A ++ R
Sbjct: 1947 EERRRREAEERVQKSLAAEEEA-ARQRKAALEEV---ERLKAKVEEARRLRERAEQESAR 2002
Query: 64 QRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREA 123
Q EA + ++E KA + ++ LQ+ +Q L++ LRG EA
Sbjct: 2003 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ----LRG-------EA 2051
Query: 124 AAAR---EEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIK 174
AAR EEAE+A + ++ AQ R + + E + + R A+ A K
Sbjct: 2052 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2105
Score = 38.9 bits (89), Expect = 0.003
Identities = 33/169 (19%), Positives = 83/169 (49%), Gaps = 8/169 (4%)
Query: 15 QKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVE---- 70
Q+++ + A+ + E+ L +++L ++ L+ ++QL Q Q ++
Sbjct: 2405 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2464
Query: 71 AELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEA 130
+E + + I E ++ Q+++ +++QL EE + + Q+E ++ A+ EEA
Sbjct: 2465 SEKDSLLQRERFIEQEKAKLEQLFQDEV-AKAQQLREEQQRQQQQMEQERQRLVASMEEA 2523
Query: 131 EQALGERDQALAQLRAHMADME---AKYEEILHDSLDRLLAKLRAIKQQ 176
+ E ++ + + + + +E + EE+L + RL +L+ +++Q
Sbjct: 2524 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2572
Score = 36.6 bits (83), Expect = 0.016
Identities = 47/183 (25%), Positives = 80/183 (43%), Gaps = 27/183 (14%)
Query: 7 EKGKKSGAQKKKKNWGADV-----VAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQ 61
E+ +S ++K K+ A+ +AE RL L +E R +R A ED
Sbjct: 1743 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR----------QRQLAEEDA 1792
Query: 62 LRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQR 121
RQR AE E +E A E +R L+ + + K+ E E + LR E
Sbjct: 1793 ARQR-----AEAERVLAEKLAAIGEATR----LKTEAEIALKEKEAENERLRRLAEDEAF 1843
Query: 122 EAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSL---DRLLAKLRAIKQQWD 178
+ E+A Q + ++ LAQLR + + ++ D+L ++ ++ A+K ++
Sbjct: 1844 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1903
Query: 179 GAA 181
AA
Sbjct: 1904 KAA 1906
Score = 36.6 bits (83), Expect = 0.016
Identities = 32/122 (26%), Positives = 53/122 (43%), Gaps = 7/122 (5%)
Query: 30 RHRLVVLEK----ELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYA 85
R R + EK +L +D +A + + + Q+ Q Q + A +E AR
Sbjct: 2473 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2532
Query: 86 EMSRQCHALQEDMQTRSKQ---LEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALA 142
+ R+ LQ+ Q R +Q L EE + LR QL+ + + AA +E+ + A
Sbjct: 2533 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2592
Query: 143 QL 144
L
Sbjct: 2593 TL 2594
Score = 35.8 bits (81), Expect = 0.027
Identities = 35/132 (26%), Positives = 57/132 (43%), Gaps = 20/132 (15%)
Query: 39 ELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKA---IYAEMSRQCHALQ 95
+ + + L +E R A+ + R+RL VEA LE R +A A+ R+ LQ
Sbjct: 1303 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1362
Query: 96 E--------------DMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQAL 141
+ D Q + + ++EE++ LR EA E A +AE A R +
Sbjct: 1363 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA---EIQAKARQAEAAERSRLRIE 1419
Query: 142 AQLRAHMADMEA 153
++R +EA
Sbjct: 1420 EEIRVVRLQLEA 1431
Score = 34.7 bits (78), Expect = 0.060
Identities = 39/155 (25%), Positives = 71/155 (45%), Gaps = 19/155 (12%)
Query: 27 AESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARS-------- 78
A+SR + V E E L+ + +A+A+ ++LR+ EAE E AR
Sbjct: 2073 AQSRRQ--VEEAERLKQSAEEQAQARAQAQAAAEKLRK-----EAEQEAARRAQAEQAAL 2125
Query: 79 -EGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGER 137
+ +A AEM + ++ ++ ++ Q+E+E+ LR QLE + EE ++ E
Sbjct: 2126 RQKQAADAEMEKHKKFAEQTLRQKA-QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2184
Query: 138 DQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRA 172
+A Q + E + + L +L A++ A
Sbjct: 2185 TEAARQ--RSQVEEELFSVRVQMEELSKLKARIEA 2217
Score = 28.9 bits (63), Expect = 3.3
Identities = 41/157 (26%), Positives = 67/157 (42%), Gaps = 35/157 (22%)
Query: 58 SEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQ--------CHALQEDMQTRSKQLEEEV 109
+ED LR + Q AELE AR A E R+ A +E+ + K EEV
Sbjct: 1923 AEDTLRSKEQ---AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1979
Query: 110 KGLRGQLEACQR-----------EAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEI 158
+ L+ ++E +R + A+E A++ L A+ +AH ++ K +E
Sbjct: 1980 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL------QAEEKAHAFAVQQKEQE- 2032
Query: 159 LHDSLDRLLAKLRAIKQQWDG--AALRLHARHKEQQR 193
L + L + +++ Q G A R A E+ R
Sbjct: 2033 ----LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2065
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 50.8 bits (120), Expect = 8e-07
Identities = 57/207 (27%), Positives = 90/207 (43%), Gaps = 26/207 (12%)
Query: 5 NKEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQ 64
N ++ + A+K K+ VAE RL V +E R D A++ +E L++
Sbjct: 2398 NTQRFLQEEAEKMKQ------VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2451
Query: 65 RLQGVEAELEGARSEGKAIYAEMSR-----QCHALQEDMQTRSKQLEEEVKGLRGQLEA- 118
++Q V+ E R + +A + + Q LQED + ++QL EE +G + LEA
Sbjct: 2452 KMQAVQ---EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2508
Query: 119 CQREAAAAREEAEQALGERDQALAQLRAHM-ADMEAKYEEILHDSLDR----------LL 167
QR+ + E L + + AQ RA A K E + + L R L+
Sbjct: 2509 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2568
Query: 168 AKLRAIKQQWDGAALRLHARHKEQQRQ 194
L +QQ D A RL E +R+
Sbjct: 2569 QTLEIQRQQSDHDAERLREAIAELERE 2595
Score = 48.1 bits (113), Expect = 5e-06
Identities = 64/210 (30%), Positives = 97/210 (46%), Gaps = 23/210 (10%)
Query: 14 AQKKKKNWGADVVAESRHRL----VVLEKELLRDHLALRRDEA-----RRAKASEDQLRQ 64
A+++ + W R RL V +K L + +++EA RR KA E +RQ
Sbjct: 1764 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1823
Query: 65 RLQGVEAELEGAR--SEGKAIYAEMSRQCHALQEDMQTRSK--QLEEEVKGLRGQLEACQ 120
R + E ELE R +EG A ++ A QE ++ R++ Q E++ + L +L Q
Sbjct: 1824 R-ELAEQELEKQRQLAEGTA-----QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1877
Query: 121 REAAAA---REEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQW 177
REAAAA R+E E L + + L A A E + S RL A+ ++
Sbjct: 1878 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1937
Query: 178 DGAALRLHARHKEQQRQFGLTPPGSLRPPA 207
+ AA RL A +E +RQ L + R A
Sbjct: 1938 EEAA-RLRALAEEAKRQRQLAEEDAARQRA 1966
Score = 47.8 bits (112), Expect = 7e-06
Identities = 34/152 (22%), Positives = 70/152 (46%), Gaps = 16/152 (10%)
Query: 27 AESRHRLVVLE------KELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEG 80
AE R RL +E ++L H + R AK + ++++ + E A+ +
Sbjct: 1493 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1552
Query: 81 KAIYAEMSRQCHALQEDMQTRSKQ----------LEEEVKGLRGQLEACQREAAAAREEA 130
++I E+ + + + ++Q +++Q +EEE++ +R QLEA +R+ A E
Sbjct: 1553 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1612
Query: 131 EQALGERDQALAQLRAHMADMEAKYEEILHDS 162
+ ++A AQ R + E ++ +S
Sbjct: 1613 QALRARAEEAEAQKRQAQEEAERLRRQVQDES 1644
Score = 43.5 bits (101), Expect = 1e-04
Identities = 51/189 (26%), Positives = 80/189 (42%), Gaps = 31/189 (16%)
Query: 23 ADVVAESRHRLVVLEKELLRDHLA---LRRDEARRAKASEDQLRQRLQGVEAELEGARSE 79
A+ E + L LE+ L+ A LR+ E RA+ + L + EAEL+ R
Sbjct: 1662 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR-- 1719
Query: 80 GKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALG---- 135
A +AE + Q ++ QL EE + Q Q EA AREEAE+ L
Sbjct: 1720 --ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ----QAEAERAREEAERELERWQL 1773
Query: 136 ----------ERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQWDGAALRLH 185
+ ++ Q A+ E + EE ++ R A+ +A++Q+ L
Sbjct: 1774 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR------ELA 1827
Query: 186 ARHKEQQRQ 194
+ E+QRQ
Sbjct: 1828 EQELEKQRQ 1836
Score = 40.4 bits (93), Expect = 0.001
Identities = 36/127 (28%), Positives = 65/127 (51%), Gaps = 15/127 (11%)
Query: 37 EKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQE 96
+++LL + LA + EA A Q+ Q +EAEL R+E + + A +R +E
Sbjct: 1865 QRQLLEEELARLQREAAAAT-------QKRQELEAELAKVRAEMEVLLASKAR----AEE 1913
Query: 97 DMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYE 156
+ ++ S++ ++ ++ G+ EAA R AE+A +R + LA+ A A A+ E
Sbjct: 1914 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA--KRQRQLAEEDA--ARQRAEAE 1969
Query: 157 EILHDSL 163
+L + L
Sbjct: 1970 RVLAEKL 1976
Score = 40.4 bits (93), Expect = 0.001
Identities = 46/174 (26%), Positives = 82/174 (47%), Gaps = 20/174 (11%)
Query: 6 KEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAK--ASEDQLR 63
+E+ ++ ++ +K+ A+ A +R R LE+ + L + +EARR + A ++ R
Sbjct: 2116 EERRRREAEERVQKSLAAEEEA-ARQRKAALEEV---ERLKAKVEEARRLRERAEQESAR 2171
Query: 64 QRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREA 123
Q EA + ++E KA + ++ LQ+ +Q L++ LRG EA
Sbjct: 2172 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ----LRG-------EA 2220
Query: 124 AAAR---EEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIK 174
AAR EEAE+A + ++ AQ R + + E + + R A+ A K
Sbjct: 2221 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2274
Score = 38.9 bits (89), Expect = 0.003
Identities = 33/169 (19%), Positives = 83/169 (49%), Gaps = 8/169 (4%)
Query: 15 QKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVE---- 70
Q+++ + A+ + E+ L +++L ++ L+ ++QL Q Q ++
Sbjct: 2574 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2633
Query: 71 AELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEA 130
+E + + I E ++ Q+++ +++QL EE + + Q+E ++ A+ EEA
Sbjct: 2634 SEKDSLLQRERFIEQEKAKLEQLFQDEV-AKAQQLREEQQRQQQQMEQERQRLVASMEEA 2692
Query: 131 EQALGERDQALAQLRAHMADME---AKYEEILHDSLDRLLAKLRAIKQQ 176
+ E ++ + + + + +E + EE+L + RL +L+ +++Q
Sbjct: 2693 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2741
Score = 36.6 bits (83), Expect = 0.016
Identities = 47/183 (25%), Positives = 80/183 (43%), Gaps = 27/183 (14%)
Query: 7 EKGKKSGAQKKKKNWGADV-----VAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQ 61
E+ +S ++K K+ A+ +AE RL L +E R +R A ED
Sbjct: 1912 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR----------QRQLAEEDA 1961
Query: 62 LRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQR 121
RQR AE E +E A E +R L+ + + K+ E E + LR E
Sbjct: 1962 ARQR-----AEAERVLAEKLAAIGEATR----LKTEAEIALKEKEAENERLRRLAEDEAF 2012
Query: 122 EAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSL---DRLLAKLRAIKQQWD 178
+ E+A Q + ++ LAQLR + + ++ D+L ++ ++ A+K ++
Sbjct: 2013 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 2072
Query: 179 GAA 181
AA
Sbjct: 2073 KAA 2075
Score = 36.6 bits (83), Expect = 0.016
Identities = 32/122 (26%), Positives = 53/122 (43%), Gaps = 7/122 (5%)
Query: 30 RHRLVVLEK----ELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYA 85
R R + EK +L +D +A + + + Q+ Q Q + A +E AR
Sbjct: 2642 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2701
Query: 86 EMSRQCHALQEDMQTRSKQ---LEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALA 142
+ R+ LQ+ Q R +Q L EE + LR QL+ + + AA +E+ + A
Sbjct: 2702 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2761
Query: 143 QL 144
L
Sbjct: 2762 TL 2763
Score = 35.8 bits (81), Expect = 0.027
Identities = 35/132 (26%), Positives = 57/132 (43%), Gaps = 20/132 (15%)
Query: 39 ELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKA---IYAEMSRQCHALQ 95
+ + + L +E R A+ + R+RL VEA LE R +A A+ R+ LQ
Sbjct: 1472 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1531
Query: 96 E--------------DMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQAL 141
+ D Q + + ++EE++ LR EA E A +AE A R +
Sbjct: 1532 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA---EIQAKARQAEAAERSRLRIE 1588
Query: 142 AQLRAHMADMEA 153
++R +EA
Sbjct: 1589 EEIRVVRLQLEA 1600
Score = 34.7 bits (78), Expect = 0.060
Identities = 39/155 (25%), Positives = 71/155 (45%), Gaps = 19/155 (12%)
Query: 27 AESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARS-------- 78
A+SR + V E E L+ + +A+A+ ++LR+ EAE E AR
Sbjct: 2242 AQSRRQ--VEEAERLKQSAEEQAQARAQAQAAAEKLRK-----EAEQEAARRAQAEQAAL 2294
Query: 79 -EGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGER 137
+ +A AEM + ++ ++ ++ Q+E+E+ LR QLE + EE ++ E
Sbjct: 2295 RQKQAADAEMEKHKKFAEQTLRQKA-QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2353
Query: 138 DQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRA 172
+A Q + E + + L +L A++ A
Sbjct: 2354 TEAARQ--RSQVEEELFSVRVQMEELSKLKARIEA 2386
Score = 28.9 bits (63), Expect = 3.3
Identities = 41/157 (26%), Positives = 67/157 (42%), Gaps = 35/157 (22%)
Query: 58 SEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQ--------CHALQEDMQTRSKQLEEEV 109
+ED LR + Q AELE AR A E R+ A +E+ + K EEV
Sbjct: 2092 AEDTLRSKEQ---AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2148
Query: 110 KGLRGQLEACQR-----------EAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEI 158
+ L+ ++E +R + A+E A++ L A+ +AH ++ K +E
Sbjct: 2149 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL------QAEEKAHAFAVQQKEQE- 2201
Query: 159 LHDSLDRLLAKLRAIKQQWDG--AALRLHARHKEQQR 193
L + L + +++ Q G A R A E+ R
Sbjct: 2202 ----LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2234
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 50.8 bits (120), Expect = 8e-07
Identities = 57/207 (27%), Positives = 90/207 (43%), Gaps = 26/207 (12%)
Query: 5 NKEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQ 64
N ++ + A+K K+ VAE RL V +E R D A++ +E L++
Sbjct: 2239 NTQRFLQEEAEKMKQ------VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2292
Query: 65 RLQGVEAELEGARSEGKAIYAEMSR-----QCHALQEDMQTRSKQLEEEVKGLRGQLEA- 118
++Q V+ E R + +A + + Q LQED + ++QL EE +G + LEA
Sbjct: 2293 KMQAVQ---EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2349
Query: 119 CQREAAAAREEAEQALGERDQALAQLRAHM-ADMEAKYEEILHDSLDR----------LL 167
QR+ + E L + + AQ RA A K E + + L R L+
Sbjct: 2350 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2409
Query: 168 AKLRAIKQQWDGAALRLHARHKEQQRQ 194
L +QQ D A RL E +R+
Sbjct: 2410 QTLEIQRQQSDHDAERLREAIAELERE 2436
Score = 48.1 bits (113), Expect = 5e-06
Identities = 64/210 (30%), Positives = 97/210 (46%), Gaps = 23/210 (10%)
Query: 14 AQKKKKNWGADVVAESRHRL----VVLEKELLRDHLALRRDEA-----RRAKASEDQLRQ 64
A+++ + W R RL V +K L + +++EA RR KA E +RQ
Sbjct: 1605 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1664
Query: 65 RLQGVEAELEGAR--SEGKAIYAEMSRQCHALQEDMQTRSK--QLEEEVKGLRGQLEACQ 120
R + E ELE R +EG A ++ A QE ++ R++ Q E++ + L +L Q
Sbjct: 1665 R-ELAEQELEKQRQLAEGTA-----QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1718
Query: 121 REAAAA---REEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQW 177
REAAAA R+E E L + + L A A E + S RL A+ ++
Sbjct: 1719 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1778
Query: 178 DGAALRLHARHKEQQRQFGLTPPGSLRPPA 207
+ AA RL A +E +RQ L + R A
Sbjct: 1779 EEAA-RLRALAEEAKRQRQLAEEDAARQRA 1807
Score = 47.8 bits (112), Expect = 7e-06
Identities = 34/152 (22%), Positives = 70/152 (46%), Gaps = 16/152 (10%)
Query: 27 AESRHRLVVLE------KELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEG 80
AE R RL +E ++L H + R AK + ++++ + E A+ +
Sbjct: 1334 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1393
Query: 81 KAIYAEMSRQCHALQEDMQTRSKQ----------LEEEVKGLRGQLEACQREAAAAREEA 130
++I E+ + + + ++Q +++Q +EEE++ +R QLEA +R+ A E
Sbjct: 1394 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1453
Query: 131 EQALGERDQALAQLRAHMADMEAKYEEILHDS 162
+ ++A AQ R + E ++ +S
Sbjct: 1454 QALRARAEEAEAQKRQAQEEAERLRRQVQDES 1485
Score = 43.5 bits (101), Expect = 1e-04
Identities = 51/189 (26%), Positives = 80/189 (42%), Gaps = 31/189 (16%)
Query: 23 ADVVAESRHRLVVLEKELLRDHLA---LRRDEARRAKASEDQLRQRLQGVEAELEGARSE 79
A+ E + L LE+ L+ A LR+ E RA+ + L + EAEL+ R
Sbjct: 1503 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR-- 1560
Query: 80 GKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALG---- 135
A +AE + Q ++ QL EE + Q Q EA AREEAE+ L
Sbjct: 1561 --ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ----QAEAERAREEAERELERWQL 1614
Query: 136 ----------ERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQWDGAALRLH 185
+ ++ Q A+ E + EE ++ R A+ +A++Q+ L
Sbjct: 1615 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR------ELA 1668
Query: 186 ARHKEQQRQ 194
+ E+QRQ
Sbjct: 1669 EQELEKQRQ 1677
Score = 40.4 bits (93), Expect = 0.001
Identities = 36/127 (28%), Positives = 65/127 (51%), Gaps = 15/127 (11%)
Query: 37 EKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQE 96
+++LL + LA + EA A Q+ Q +EAEL R+E + + A +R +E
Sbjct: 1706 QRQLLEEELARLQREAAAAT-------QKRQELEAELAKVRAEMEVLLASKAR----AEE 1754
Query: 97 DMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYE 156
+ ++ S++ ++ ++ G+ EAA R AE+A +R + LA+ A A A+ E
Sbjct: 1755 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA--KRQRQLAEEDA--ARQRAEAE 1810
Query: 157 EILHDSL 163
+L + L
Sbjct: 1811 RVLAEKL 1817
Score = 40.4 bits (93), Expect = 0.001
Identities = 46/174 (26%), Positives = 82/174 (47%), Gaps = 20/174 (11%)
Query: 6 KEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAK--ASEDQLR 63
+E+ ++ ++ +K+ A+ A +R R LE+ + L + +EARR + A ++ R
Sbjct: 1957 EERRRREAEERVQKSLAAEEEA-ARQRKAALEEV---ERLKAKVEEARRLRERAEQESAR 2012
Query: 64 QRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREA 123
Q EA + ++E KA + ++ LQ+ +Q L++ LRG EA
Sbjct: 2013 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ----LRG-------EA 2061
Query: 124 AAAR---EEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIK 174
AAR EEAE+A + ++ AQ R + + E + + R A+ A K
Sbjct: 2062 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2115
Score = 38.9 bits (89), Expect = 0.003
Identities = 33/169 (19%), Positives = 83/169 (49%), Gaps = 8/169 (4%)
Query: 15 QKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVE---- 70
Q+++ + A+ + E+ L +++L ++ L+ ++QL Q Q ++
Sbjct: 2415 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2474
Query: 71 AELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEA 130
+E + + I E ++ Q+++ +++QL EE + + Q+E ++ A+ EEA
Sbjct: 2475 SEKDSLLQRERFIEQEKAKLEQLFQDEV-AKAQQLREEQQRQQQQMEQERQRLVASMEEA 2533
Query: 131 EQALGERDQALAQLRAHMADME---AKYEEILHDSLDRLLAKLRAIKQQ 176
+ E ++ + + + + +E + EE+L + RL +L+ +++Q
Sbjct: 2534 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2582
Score = 36.6 bits (83), Expect = 0.016
Identities = 47/183 (25%), Positives = 80/183 (43%), Gaps = 27/183 (14%)
Query: 7 EKGKKSGAQKKKKNWGADV-----VAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQ 61
E+ +S ++K K+ A+ +AE RL L +E R +R A ED
Sbjct: 1753 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR----------QRQLAEEDA 1802
Query: 62 LRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQR 121
RQR AE E +E A E +R L+ + + K+ E E + LR E
Sbjct: 1803 ARQR-----AEAERVLAEKLAAIGEATR----LKTEAEIALKEKEAENERLRRLAEDEAF 1853
Query: 122 EAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSL---DRLLAKLRAIKQQWD 178
+ E+A Q + ++ LAQLR + + ++ D+L ++ ++ A+K ++
Sbjct: 1854 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1913
Query: 179 GAA 181
AA
Sbjct: 1914 KAA 1916
Score = 36.6 bits (83), Expect = 0.016
Identities = 32/122 (26%), Positives = 53/122 (43%), Gaps = 7/122 (5%)
Query: 30 RHRLVVLEK----ELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYA 85
R R + EK +L +D +A + + + Q+ Q Q + A +E AR
Sbjct: 2483 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2542
Query: 86 EMSRQCHALQEDMQTRSKQ---LEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALA 142
+ R+ LQ+ Q R +Q L EE + LR QL+ + + AA +E+ + A
Sbjct: 2543 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2602
Query: 143 QL 144
L
Sbjct: 2603 TL 2604
Score = 35.8 bits (81), Expect = 0.027
Identities = 35/132 (26%), Positives = 57/132 (43%), Gaps = 20/132 (15%)
Query: 39 ELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKA---IYAEMSRQCHALQ 95
+ + + L +E R A+ + R+RL VEA LE R +A A+ R+ LQ
Sbjct: 1313 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1372
Query: 96 E--------------DMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQAL 141
+ D Q + + ++EE++ LR EA E A +AE A R +
Sbjct: 1373 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA---EIQAKARQAEAAERSRLRIE 1429
Query: 142 AQLRAHMADMEA 153
++R +EA
Sbjct: 1430 EEIRVVRLQLEA 1441
Score = 34.7 bits (78), Expect = 0.060
Identities = 39/155 (25%), Positives = 71/155 (45%), Gaps = 19/155 (12%)
Query: 27 AESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARS-------- 78
A+SR + V E E L+ + +A+A+ ++LR+ EAE E AR
Sbjct: 2083 AQSRRQ--VEEAERLKQSAEEQAQARAQAQAAAEKLRK-----EAEQEAARRAQAEQAAL 2135
Query: 79 -EGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGER 137
+ +A AEM + ++ ++ ++ Q+E+E+ LR QLE + EE ++ E
Sbjct: 2136 RQKQAADAEMEKHKKFAEQTLRQKA-QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2194
Query: 138 DQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRA 172
+A Q + E + + L +L A++ A
Sbjct: 2195 TEAARQ--RSQVEEELFSVRVQMEELSKLKARIEA 2227
Score = 28.9 bits (63), Expect = 3.3
Identities = 41/157 (26%), Positives = 67/157 (42%), Gaps = 35/157 (22%)
Query: 58 SEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQ--------CHALQEDMQTRSKQLEEEV 109
+ED LR + Q AELE AR A E R+ A +E+ + K EEV
Sbjct: 1933 AEDTLRSKEQ---AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1989
Query: 110 KGLRGQLEACQR-----------EAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEI 158
+ L+ ++E +R + A+E A++ L A+ +AH ++ K +E
Sbjct: 1990 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL------QAEEKAHAFAVQQKEQE- 2042
Query: 159 LHDSLDRLLAKLRAIKQQWDG--AALRLHARHKEQQR 193
L + L + +++ Q G A R A E+ R
Sbjct: 2043 ----LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2075
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 50.8 bits (120), Expect = 8e-07
Identities = 57/207 (27%), Positives = 90/207 (43%), Gaps = 26/207 (12%)
Query: 5 NKEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQ 64
N ++ + A+K K+ VAE RL V +E R D A++ +E L++
Sbjct: 2247 NTQRFLQEEAEKMKQ------VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2300
Query: 65 RLQGVEAELEGARSEGKAIYAEMSR-----QCHALQEDMQTRSKQLEEEVKGLRGQLEA- 118
++Q V+ E R + +A + + Q LQED + ++QL EE +G + LEA
Sbjct: 2301 KMQAVQ---EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2357
Query: 119 CQREAAAAREEAEQALGERDQALAQLRAHM-ADMEAKYEEILHDSLDR----------LL 167
QR+ + E L + + AQ RA A K E + + L R L+
Sbjct: 2358 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2417
Query: 168 AKLRAIKQQWDGAALRLHARHKEQQRQ 194
L +QQ D A RL E +R+
Sbjct: 2418 QTLEIQRQQSDHDAERLREAIAELERE 2444
Score = 48.1 bits (113), Expect = 5e-06
Identities = 64/210 (30%), Positives = 97/210 (46%), Gaps = 23/210 (10%)
Query: 14 AQKKKKNWGADVVAESRHRL----VVLEKELLRDHLALRRDEA-----RRAKASEDQLRQ 64
A+++ + W R RL V +K L + +++EA RR KA E +RQ
Sbjct: 1613 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1672
Query: 65 RLQGVEAELEGAR--SEGKAIYAEMSRQCHALQEDMQTRSK--QLEEEVKGLRGQLEACQ 120
R + E ELE R +EG A ++ A QE ++ R++ Q E++ + L +L Q
Sbjct: 1673 R-ELAEQELEKQRQLAEGTA-----QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1726
Query: 121 REAAAA---REEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQW 177
REAAAA R+E E L + + L A A E + S RL A+ ++
Sbjct: 1727 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1786
Query: 178 DGAALRLHARHKEQQRQFGLTPPGSLRPPA 207
+ AA RL A +E +RQ L + R A
Sbjct: 1787 EEAA-RLRALAEEAKRQRQLAEEDAARQRA 1815
Score = 47.8 bits (112), Expect = 7e-06
Identities = 34/152 (22%), Positives = 70/152 (46%), Gaps = 16/152 (10%)
Query: 27 AESRHRLVVLE------KELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEG 80
AE R RL +E ++L H + R AK + ++++ + E A+ +
Sbjct: 1342 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1401
Query: 81 KAIYAEMSRQCHALQEDMQTRSKQ----------LEEEVKGLRGQLEACQREAAAAREEA 130
++I E+ + + + ++Q +++Q +EEE++ +R QLEA +R+ A E
Sbjct: 1402 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1461
Query: 131 EQALGERDQALAQLRAHMADMEAKYEEILHDS 162
+ ++A AQ R + E ++ +S
Sbjct: 1462 QALRARAEEAEAQKRQAQEEAERLRRQVQDES 1493
Score = 43.5 bits (101), Expect = 1e-04
Identities = 51/189 (26%), Positives = 80/189 (42%), Gaps = 31/189 (16%)
Query: 23 ADVVAESRHRLVVLEKELLRDHLA---LRRDEARRAKASEDQLRQRLQGVEAELEGARSE 79
A+ E + L LE+ L+ A LR+ E RA+ + L + EAEL+ R
Sbjct: 1511 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR-- 1568
Query: 80 GKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALG---- 135
A +AE + Q ++ QL EE + Q Q EA AREEAE+ L
Sbjct: 1569 --ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ----QAEAERAREEAERELERWQL 1622
Query: 136 ----------ERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQWDGAALRLH 185
+ ++ Q A+ E + EE ++ R A+ +A++Q+ L
Sbjct: 1623 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR------ELA 1676
Query: 186 ARHKEQQRQ 194
+ E+QRQ
Sbjct: 1677 EQELEKQRQ 1685
Score = 40.4 bits (93), Expect = 0.001
Identities = 36/127 (28%), Positives = 65/127 (51%), Gaps = 15/127 (11%)
Query: 37 EKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQE 96
+++LL + LA + EA A Q+ Q +EAEL R+E + + A +R +E
Sbjct: 1714 QRQLLEEELARLQREAAAAT-------QKRQELEAELAKVRAEMEVLLASKAR----AEE 1762
Query: 97 DMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYE 156
+ ++ S++ ++ ++ G+ EAA R AE+A +R + LA+ A A A+ E
Sbjct: 1763 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA--KRQRQLAEEDA--ARQRAEAE 1818
Query: 157 EILHDSL 163
+L + L
Sbjct: 1819 RVLAEKL 1825
Score = 40.4 bits (93), Expect = 0.001
Identities = 46/174 (26%), Positives = 82/174 (47%), Gaps = 20/174 (11%)
Query: 6 KEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAK--ASEDQLR 63
+E+ ++ ++ +K+ A+ A +R R LE+ + L + +EARR + A ++ R
Sbjct: 1965 EERRRREAEERVQKSLAAEEEA-ARQRKAALEEV---ERLKAKVEEARRLRERAEQESAR 2020
Query: 64 QRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREA 123
Q EA + ++E KA + ++ LQ+ +Q L++ LRG EA
Sbjct: 2021 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ----LRG-------EA 2069
Query: 124 AAAR---EEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIK 174
AAR EEAE+A + ++ AQ R + + E + + R A+ A K
Sbjct: 2070 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2123
Score = 38.9 bits (89), Expect = 0.003
Identities = 33/169 (19%), Positives = 83/169 (49%), Gaps = 8/169 (4%)
Query: 15 QKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVE---- 70
Q+++ + A+ + E+ L +++L ++ L+ ++QL Q Q ++
Sbjct: 2423 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2482
Query: 71 AELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEA 130
+E + + I E ++ Q+++ +++QL EE + + Q+E ++ A+ EEA
Sbjct: 2483 SEKDSLLQRERFIEQEKAKLEQLFQDEV-AKAQQLREEQQRQQQQMEQERQRLVASMEEA 2541
Query: 131 EQALGERDQALAQLRAHMADME---AKYEEILHDSLDRLLAKLRAIKQQ 176
+ E ++ + + + + +E + EE+L + RL +L+ +++Q
Sbjct: 2542 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2590
Score = 36.6 bits (83), Expect = 0.016
Identities = 47/183 (25%), Positives = 80/183 (43%), Gaps = 27/183 (14%)
Query: 7 EKGKKSGAQKKKKNWGADV-----VAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQ 61
E+ +S ++K K+ A+ +AE RL L +E R +R A ED
Sbjct: 1761 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR----------QRQLAEEDA 1810
Query: 62 LRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQR 121
RQR AE E +E A E +R L+ + + K+ E E + LR E
Sbjct: 1811 ARQR-----AEAERVLAEKLAAIGEATR----LKTEAEIALKEKEAENERLRRLAEDEAF 1861
Query: 122 EAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSL---DRLLAKLRAIKQQWD 178
+ E+A Q + ++ LAQLR + + ++ D+L ++ ++ A+K ++
Sbjct: 1862 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1921
Query: 179 GAA 181
AA
Sbjct: 1922 KAA 1924
Score = 36.6 bits (83), Expect = 0.016
Identities = 32/122 (26%), Positives = 53/122 (43%), Gaps = 7/122 (5%)
Query: 30 RHRLVVLEK----ELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYA 85
R R + EK +L +D +A + + + Q+ Q Q + A +E AR
Sbjct: 2491 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2550
Query: 86 EMSRQCHALQEDMQTRSKQ---LEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALA 142
+ R+ LQ+ Q R +Q L EE + LR QL+ + + AA +E+ + A
Sbjct: 2551 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2610
Query: 143 QL 144
L
Sbjct: 2611 TL 2612
Score = 35.8 bits (81), Expect = 0.027
Identities = 35/132 (26%), Positives = 57/132 (43%), Gaps = 20/132 (15%)
Query: 39 ELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKA---IYAEMSRQCHALQ 95
+ + + L +E R A+ + R+RL VEA LE R +A A+ R+ LQ
Sbjct: 1321 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1380
Query: 96 E--------------DMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQAL 141
+ D Q + + ++EE++ LR EA E A +AE A R +
Sbjct: 1381 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA---EIQAKARQAEAAERSRLRIE 1437
Query: 142 AQLRAHMADMEA 153
++R +EA
Sbjct: 1438 EEIRVVRLQLEA 1449
Score = 34.7 bits (78), Expect = 0.060
Identities = 39/155 (25%), Positives = 71/155 (45%), Gaps = 19/155 (12%)
Query: 27 AESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARS-------- 78
A+SR + V E E L+ + +A+A+ ++LR+ EAE E AR
Sbjct: 2091 AQSRRQ--VEEAERLKQSAEEQAQARAQAQAAAEKLRK-----EAEQEAARRAQAEQAAL 2143
Query: 79 -EGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGER 137
+ +A AEM + ++ ++ ++ Q+E+E+ LR QLE + EE ++ E
Sbjct: 2144 RQKQAADAEMEKHKKFAEQTLRQKA-QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2202
Query: 138 DQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRA 172
+A Q + E + + L +L A++ A
Sbjct: 2203 TEAARQ--RSQVEEELFSVRVQMEELSKLKARIEA 2235
Score = 28.9 bits (63), Expect = 3.3
Identities = 41/157 (26%), Positives = 67/157 (42%), Gaps = 35/157 (22%)
Query: 58 SEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQ--------CHALQEDMQTRSKQLEEEV 109
+ED LR + Q AELE AR A E R+ A +E+ + K EEV
Sbjct: 1941 AEDTLRSKEQ---AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1997
Query: 110 KGLRGQLEACQR-----------EAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEI 158
+ L+ ++E +R + A+E A++ L A+ +AH ++ K +E
Sbjct: 1998 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL------QAEEKAHAFAVQQKEQE- 2050
Query: 159 LHDSLDRLLAKLRAIKQQWDG--AALRLHARHKEQQR 193
L + L + +++ Q G A R A E+ R
Sbjct: 2051 ----LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2083
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 50.8 bits (120), Expect = 8e-07
Identities = 57/207 (27%), Positives = 90/207 (43%), Gaps = 26/207 (12%)
Query: 5 NKEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQ 64
N ++ + A+K K+ VAE RL V +E R D A++ +E L++
Sbjct: 2288 NTQRFLQEEAEKMKQ------VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2341
Query: 65 RLQGVEAELEGARSEGKAIYAEMSR-----QCHALQEDMQTRSKQLEEEVKGLRGQLEA- 118
++Q V+ E R + +A + + Q LQED + ++QL EE +G + LEA
Sbjct: 2342 KMQAVQ---EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2398
Query: 119 CQREAAAAREEAEQALGERDQALAQLRAHM-ADMEAKYEEILHDSLDR----------LL 167
QR+ + E L + + AQ RA A K E + + L R L+
Sbjct: 2399 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2458
Query: 168 AKLRAIKQQWDGAALRLHARHKEQQRQ 194
L +QQ D A RL E +R+
Sbjct: 2459 QTLEIQRQQSDHDAERLREAIAELERE 2485
Score = 48.1 bits (113), Expect = 5e-06
Identities = 64/210 (30%), Positives = 97/210 (46%), Gaps = 23/210 (10%)
Query: 14 AQKKKKNWGADVVAESRHRL----VVLEKELLRDHLALRRDEA-----RRAKASEDQLRQ 64
A+++ + W R RL V +K L + +++EA RR KA E +RQ
Sbjct: 1654 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1713
Query: 65 RLQGVEAELEGAR--SEGKAIYAEMSRQCHALQEDMQTRSK--QLEEEVKGLRGQLEACQ 120
R + E ELE R +EG A ++ A QE ++ R++ Q E++ + L +L Q
Sbjct: 1714 R-ELAEQELEKQRQLAEGTA-----QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1767
Query: 121 REAAAA---REEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQW 177
REAAAA R+E E L + + L A A E + S RL A+ ++
Sbjct: 1768 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1827
Query: 178 DGAALRLHARHKEQQRQFGLTPPGSLRPPA 207
+ AA RL A +E +RQ L + R A
Sbjct: 1828 EEAA-RLRALAEEAKRQRQLAEEDAARQRA 1856
Score = 47.8 bits (112), Expect = 7e-06
Identities = 34/152 (22%), Positives = 70/152 (46%), Gaps = 16/152 (10%)
Query: 27 AESRHRLVVLE------KELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEG 80
AE R RL +E ++L H + R AK + ++++ + E A+ +
Sbjct: 1383 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1442
Query: 81 KAIYAEMSRQCHALQEDMQTRSKQ----------LEEEVKGLRGQLEACQREAAAAREEA 130
++I E+ + + + ++Q +++Q +EEE++ +R QLEA +R+ A E
Sbjct: 1443 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1502
Query: 131 EQALGERDQALAQLRAHMADMEAKYEEILHDS 162
+ ++A AQ R + E ++ +S
Sbjct: 1503 QALRARAEEAEAQKRQAQEEAERLRRQVQDES 1534
Score = 43.5 bits (101), Expect = 1e-04
Identities = 51/189 (26%), Positives = 80/189 (42%), Gaps = 31/189 (16%)
Query: 23 ADVVAESRHRLVVLEKELLRDHLA---LRRDEARRAKASEDQLRQRLQGVEAELEGARSE 79
A+ E + L LE+ L+ A LR+ E RA+ + L + EAEL+ R
Sbjct: 1552 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR-- 1609
Query: 80 GKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALG---- 135
A +AE + Q ++ QL EE + Q Q EA AREEAE+ L
Sbjct: 1610 --ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ----QAEAERAREEAERELERWQL 1663
Query: 136 ----------ERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQWDGAALRLH 185
+ ++ Q A+ E + EE ++ R A+ +A++Q+ L
Sbjct: 1664 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR------ELA 1717
Query: 186 ARHKEQQRQ 194
+ E+QRQ
Sbjct: 1718 EQELEKQRQ 1726
Score = 40.4 bits (93), Expect = 0.001
Identities = 36/127 (28%), Positives = 65/127 (51%), Gaps = 15/127 (11%)
Query: 37 EKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQE 96
+++LL + LA + EA A Q+ Q +EAEL R+E + + A +R +E
Sbjct: 1755 QRQLLEEELARLQREAAAAT-------QKRQELEAELAKVRAEMEVLLASKAR----AEE 1803
Query: 97 DMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYE 156
+ ++ S++ ++ ++ G+ EAA R AE+A +R + LA+ A A A+ E
Sbjct: 1804 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA--KRQRQLAEEDA--ARQRAEAE 1859
Query: 157 EILHDSL 163
+L + L
Sbjct: 1860 RVLAEKL 1866
Score = 40.4 bits (93), Expect = 0.001
Identities = 46/174 (26%), Positives = 82/174 (47%), Gaps = 20/174 (11%)
Query: 6 KEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAK--ASEDQLR 63
+E+ ++ ++ +K+ A+ A +R R LE+ + L + +EARR + A ++ R
Sbjct: 2006 EERRRREAEERVQKSLAAEEEA-ARQRKAALEEV---ERLKAKVEEARRLRERAEQESAR 2061
Query: 64 QRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREA 123
Q EA + ++E KA + ++ LQ+ +Q L++ LRG EA
Sbjct: 2062 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ----LRG-------EA 2110
Query: 124 AAAR---EEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIK 174
AAR EEAE+A + ++ AQ R + + E + + R A+ A K
Sbjct: 2111 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2164
Score = 38.9 bits (89), Expect = 0.003
Identities = 33/169 (19%), Positives = 83/169 (49%), Gaps = 8/169 (4%)
Query: 15 QKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVE---- 70
Q+++ + A+ + E+ L +++L ++ L+ ++QL Q Q ++
Sbjct: 2464 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2523
Query: 71 AELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEA 130
+E + + I E ++ Q+++ +++QL EE + + Q+E ++ A+ EEA
Sbjct: 2524 SEKDSLLQRERFIEQEKAKLEQLFQDEV-AKAQQLREEQQRQQQQMEQERQRLVASMEEA 2582
Query: 131 EQALGERDQALAQLRAHMADME---AKYEEILHDSLDRLLAKLRAIKQQ 176
+ E ++ + + + + +E + EE+L + RL +L+ +++Q
Sbjct: 2583 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2631
Score = 36.6 bits (83), Expect = 0.016
Identities = 47/183 (25%), Positives = 80/183 (43%), Gaps = 27/183 (14%)
Query: 7 EKGKKSGAQKKKKNWGADV-----VAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQ 61
E+ +S ++K K+ A+ +AE RL L +E R +R A ED
Sbjct: 1802 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR----------QRQLAEEDA 1851
Query: 62 LRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQR 121
RQR AE E +E A E +R L+ + + K+ E E + LR E
Sbjct: 1852 ARQR-----AEAERVLAEKLAAIGEATR----LKTEAEIALKEKEAENERLRRLAEDEAF 1902
Query: 122 EAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSL---DRLLAKLRAIKQQWD 178
+ E+A Q + ++ LAQLR + + ++ D+L ++ ++ A+K ++
Sbjct: 1903 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1962
Query: 179 GAA 181
AA
Sbjct: 1963 KAA 1965
Score = 36.6 bits (83), Expect = 0.016
Identities = 32/122 (26%), Positives = 53/122 (43%), Gaps = 7/122 (5%)
Query: 30 RHRLVVLEK----ELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYA 85
R R + EK +L +D +A + + + Q+ Q Q + A +E AR
Sbjct: 2532 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2591
Query: 86 EMSRQCHALQEDMQTRSKQ---LEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALA 142
+ R+ LQ+ Q R +Q L EE + LR QL+ + + AA +E+ + A
Sbjct: 2592 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2651
Query: 143 QL 144
L
Sbjct: 2652 TL 2653
Score = 35.8 bits (81), Expect = 0.027
Identities = 35/132 (26%), Positives = 57/132 (43%), Gaps = 20/132 (15%)
Query: 39 ELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKA---IYAEMSRQCHALQ 95
+ + + L +E R A+ + R+RL VEA LE R +A A+ R+ LQ
Sbjct: 1362 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1421
Query: 96 E--------------DMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQAL 141
+ D Q + + ++EE++ LR EA E A +AE A R +
Sbjct: 1422 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA---EIQAKARQAEAAERSRLRIE 1478
Query: 142 AQLRAHMADMEA 153
++R +EA
Sbjct: 1479 EEIRVVRLQLEA 1490
Score = 34.7 bits (78), Expect = 0.060
Identities = 39/155 (25%), Positives = 71/155 (45%), Gaps = 19/155 (12%)
Query: 27 AESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARS-------- 78
A+SR + V E E L+ + +A+A+ ++LR+ EAE E AR
Sbjct: 2132 AQSRRQ--VEEAERLKQSAEEQAQARAQAQAAAEKLRK-----EAEQEAARRAQAEQAAL 2184
Query: 79 -EGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGER 137
+ +A AEM + ++ ++ ++ Q+E+E+ LR QLE + EE ++ E
Sbjct: 2185 RQKQAADAEMEKHKKFAEQTLRQKA-QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2243
Query: 138 DQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRA 172
+A Q + E + + L +L A++ A
Sbjct: 2244 TEAARQ--RSQVEEELFSVRVQMEELSKLKARIEA 2276
Score = 28.9 bits (63), Expect = 3.3
Identities = 41/157 (26%), Positives = 67/157 (42%), Gaps = 35/157 (22%)
Query: 58 SEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQ--------CHALQEDMQTRSKQLEEEV 109
+ED LR + Q AELE AR A E R+ A +E+ + K EEV
Sbjct: 1982 AEDTLRSKEQ---AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2038
Query: 110 KGLRGQLEACQR-----------EAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEI 158
+ L+ ++E +R + A+E A++ L A+ +AH ++ K +E
Sbjct: 2039 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL------QAEEKAHAFAVQQKEQE- 2091
Query: 159 LHDSLDRLLAKLRAIKQQWDG--AALRLHARHKEQQR 193
L + L + +++ Q G A R A E+ R
Sbjct: 2092 ----LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2124
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 48.9 bits (115), Expect = 3e-06
Identities = 42/171 (24%), Positives = 78/171 (45%), Gaps = 15/171 (8%)
Query: 36 LEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQ 95
LE +L L + +E +R R RLQ E E +A+ +++SR A
Sbjct: 1258 LEDQL--SELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFT 1315
Query: 96 EDMQTRSKQLEEEVK---GLRGQLEACQREAAAAR---EEAEQALGERDQALAQLRAHMA 149
+ ++ +QLEEE+K L L++ + + R EE +++ E +AL++ +A
Sbjct: 1316 QQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVA 1375
Query: 150 DMEAKYE-------EILHDSLDRLLAKLRAIKQQWDGAALRLHARHKEQQR 193
KYE E L ++ +L +L+A ++ + + + K +QR
Sbjct: 1376 QWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQR 1426
Score = 35.0 bits (79), Expect = 0.046
Identities = 32/159 (20%), Positives = 66/159 (41%), Gaps = 6/159 (3%)
Query: 38 KELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQED 97
K L L L ++ + + QL ++L+ E E+ +S+ + A + Q ++
Sbjct: 1058 KRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQA-LGIQLQKKIKE 1116
Query: 98 MQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYEE 157
+Q R ++LEEE++ R +++ + E E+ + ER + + +M K E
Sbjct: 1117 LQARIEELEEEIEAERASRAKAEKQRSDLSRELEE-ISERLEEAGGATSAQIEMNKKREA 1175
Query: 158 ILHDSLDRLLAKLRAIKQQWDGAALRLHARHKEQQRQFG 196
++ L Q + A L +H + + G
Sbjct: 1176 ----EFQKMRRDLEEATLQHEATAATLRKKHADSVAELG 1210
Score = 33.5 bits (75), Expect = 0.13
Identities = 29/154 (18%), Positives = 72/154 (46%), Gaps = 19/154 (12%)
Query: 27 AESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAE 86
AE + + + + ++ + L +D + + + + Q ++ ++ L+ A
Sbjct: 1757 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQ-------- 1808
Query: 87 MSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRA 146
+ + + ++LE V+ L G++E+ Q+ A EA + L + ++ + +L
Sbjct: 1809 ------LALKGGKKQIQKLEARVRELEGEVESEQKRNA----EAVKGLRKHERRVKEL-T 1857
Query: 147 HMADMEAKYEEILHDSLDRLLAKLRAIKQQWDGA 180
+ + + K L D +D+L AK+++ K+Q + A
Sbjct: 1858 YQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEA 1891
Score = 32.0 bits (71), Expect = 0.39
Identities = 23/117 (19%), Positives = 56/117 (47%), Gaps = 23/117 (19%)
Query: 63 RQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDM------QTRSKQLEEEVKGL---- 112
+Q+ + AELE ++ E +++ E+ + +A +E + + +K L++E+ L
Sbjct: 1463 KQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQI 1522
Query: 113 -------------RGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYE 156
+ Q+E + E AA EEAE +L + + +++ + ++++ +
Sbjct: 1523 AEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVD 1579
Score = 28.9 bits (63), Expect = 3.3
Identities = 29/109 (26%), Positives = 53/109 (48%), Gaps = 10/109 (9%)
Query: 50 DEARRAKASEDQLRQRLQGVEAEL-EGARS--EGKAIYAEMSRQCHALQEDMQTRSKQLE 106
D+ K L+Q + + ++ EG + E + I ++ ++ LQ ++ LE
Sbjct: 1499 DQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLE 1558
Query: 107 -EEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQL-RAHMADMEA 153
EE K LR QLE Q + E ++ + E+D+ + QL R H+ +E+
Sbjct: 1559 HEEGKILRIQLELNQ-----VKSEVDRKIAEKDEEIDQLKRNHIRIVES 1602
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 48.9 bits (115), Expect = 3e-06
Identities = 42/171 (24%), Positives = 78/171 (45%), Gaps = 15/171 (8%)
Query: 36 LEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQ 95
LE +L L + +E +R R RLQ E E +A+ +++SR A
Sbjct: 1258 LEDQL--SELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFT 1315
Query: 96 EDMQTRSKQLEEEVK---GLRGQLEACQREAAAAR---EEAEQALGERDQALAQLRAHMA 149
+ ++ +QLEEE+K L L++ + + R EE +++ E +AL++ +A
Sbjct: 1316 QQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVA 1375
Query: 150 DMEAKYE-------EILHDSLDRLLAKLRAIKQQWDGAALRLHARHKEQQR 193
KYE E L ++ +L +L+A ++ + + + K +QR
Sbjct: 1376 QWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQR 1426
Score = 35.0 bits (79), Expect = 0.046
Identities = 32/159 (20%), Positives = 66/159 (41%), Gaps = 6/159 (3%)
Query: 38 KELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQED 97
K L L L ++ + + QL ++L+ E E+ +S+ + A + Q ++
Sbjct: 1058 KRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQA-LGIQLQKKIKE 1116
Query: 98 MQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYEE 157
+Q R ++LEEE++ R +++ + E E+ + ER + + +M K E
Sbjct: 1117 LQARIEELEEEIEAERASRAKAEKQRSDLSRELEE-ISERLEEAGGATSAQIEMNKKREA 1175
Query: 158 ILHDSLDRLLAKLRAIKQQWDGAALRLHARHKEQQRQFG 196
++ L Q + A L +H + + G
Sbjct: 1176 ----EFQKMRRDLEEATLQHEATAATLRKKHADSVAELG 1210
Score = 33.5 bits (75), Expect = 0.13
Identities = 29/154 (18%), Positives = 72/154 (46%), Gaps = 19/154 (12%)
Query: 27 AESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAE 86
AE + + + + ++ + L +D + + + + Q ++ ++ L+ A
Sbjct: 1757 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQ-------- 1808
Query: 87 MSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRA 146
+ + + ++LE V+ L G++E+ Q+ A EA + L + ++ + +L
Sbjct: 1809 ------LALKGGKKQIQKLEARVRELEGEVESEQKRNA----EAVKGLRKHERRVKEL-T 1857
Query: 147 HMADMEAKYEEILHDSLDRLLAKLRAIKQQWDGA 180
+ + + K L D +D+L AK+++ K+Q + A
Sbjct: 1858 YQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEA 1891
Score = 32.0 bits (71), Expect = 0.39
Identities = 23/117 (19%), Positives = 56/117 (47%), Gaps = 23/117 (19%)
Query: 63 RQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDM------QTRSKQLEEEVKGL---- 112
+Q+ + AELE ++ E +++ E+ + +A +E + + +K L++E+ L
Sbjct: 1463 KQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQI 1522
Query: 113 -------------RGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYE 156
+ Q+E + E AA EEAE +L + + +++ + ++++ +
Sbjct: 1523 AEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVD 1579
Score = 28.9 bits (63), Expect = 3.3
Identities = 29/109 (26%), Positives = 53/109 (48%), Gaps = 10/109 (9%)
Query: 50 DEARRAKASEDQLRQRLQGVEAEL-EGARS--EGKAIYAEMSRQCHALQEDMQTRSKQLE 106
D+ K L+Q + + ++ EG + E + I ++ ++ LQ ++ LE
Sbjct: 1499 DQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLE 1558
Query: 107 -EEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQL-RAHMADMEA 153
EE K LR QLE Q + E ++ + E+D+ + QL R H+ +E+
Sbjct: 1559 HEEGKILRIQLELNQ-----VKSEVDRKIAEKDEEIDQLKRNHIRIVES 1602
>gi|110611218 ribosome binding protein 1 [Homo sapiens]
Length = 977
Score = 48.5 bits (114), Expect = 4e-06
Identities = 49/199 (24%), Positives = 93/199 (46%), Gaps = 18/199 (9%)
Query: 4 KNKEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLR 63
K +KG K++ ++A + V + +L + + ++A+ A A E +++
Sbjct: 254 KATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAA-AGEAKVK 312
Query: 64 QRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREA 123
++L E E+ ++ +A Y E ++ LQ ++T +QLE G QL Q+E
Sbjct: 313 KQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLE---NGPNTQLARLQQEN 369
Query: 124 AAAREEAEQALGE----RDQALAQLRAHMA----DMEAKYEEILHDSLDR--LLAKLRAI 173
+ R+ QA + ++ LA+LR ++ ++ K E + D R L AK A
Sbjct: 370 SILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAF 429
Query: 174 KQQWDGAALRLHARHKEQQ 192
++Q L+L A H+E +
Sbjct: 430 EKQ----VLQLQASHRESE 444
Score = 43.9 bits (102), Expect = 1e-04
Identities = 46/170 (27%), Positives = 75/170 (44%), Gaps = 23/170 (13%)
Query: 26 VAESRHRLVVLEKELLR--DHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAI 83
+AE +L E E+ + L+ + + A+A QL +R++ +EA LE G+A
Sbjct: 482 MAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEA----GQAR 537
Query: 84 YAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQL----EACQRE-------------AAAA 126
A+ + A + QTR K+LE +V GL + EA +++ A A
Sbjct: 538 DAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEA 597
Query: 127 REEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQ 176
AEQA E+ +L Q + E ++L LL +L + QQ
Sbjct: 598 LATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQ 647
Score = 33.5 bits (75), Expect = 0.13
Identities = 33/133 (24%), Positives = 60/133 (45%), Gaps = 27/133 (20%)
Query: 30 RHRLVVLEKELLRDHLALRR-----DEARRAKASEDQLRQRLQGVEAELEGARSEGKAIY 84
R ++ E+EL + + ++ ++ + S DQ+R+ +EAELE
Sbjct: 724 RAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELE-------KHM 776
Query: 85 AEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQL 144
A S +C + +EV GLR L Q + AA+ EA++ E LA +
Sbjct: 777 AAASAEC-----------QNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDE----LALV 821
Query: 145 RAHMADMEAKYEE 157
R +++M++ E+
Sbjct: 822 RQQLSEMKSHVED 834
>gi|110611220 ribosome binding protein 1 [Homo sapiens]
Length = 977
Score = 48.5 bits (114), Expect = 4e-06
Identities = 49/199 (24%), Positives = 93/199 (46%), Gaps = 18/199 (9%)
Query: 4 KNKEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLR 63
K +KG K++ ++A + V + +L + + ++A+ A A E +++
Sbjct: 254 KATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAA-AGEAKVK 312
Query: 64 QRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREA 123
++L E E+ ++ +A Y E ++ LQ ++T +QLE G QL Q+E
Sbjct: 313 KQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLE---NGPNTQLARLQQEN 369
Query: 124 AAAREEAEQALGE----RDQALAQLRAHMA----DMEAKYEEILHDSLDR--LLAKLRAI 173
+ R+ QA + ++ LA+LR ++ ++ K E + D R L AK A
Sbjct: 370 SILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAF 429
Query: 174 KQQWDGAALRLHARHKEQQ 192
++Q L+L A H+E +
Sbjct: 430 EKQ----VLQLQASHRESE 444
Score = 43.9 bits (102), Expect = 1e-04
Identities = 46/170 (27%), Positives = 75/170 (44%), Gaps = 23/170 (13%)
Query: 26 VAESRHRLVVLEKELLR--DHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAI 83
+AE +L E E+ + L+ + + A+A QL +R++ +EA LE G+A
Sbjct: 482 MAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEA----GQAR 537
Query: 84 YAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQL----EACQRE-------------AAAA 126
A+ + A + QTR K+LE +V GL + EA +++ A A
Sbjct: 538 DAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEA 597
Query: 127 REEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQ 176
AEQA E+ +L Q + E ++L LL +L + QQ
Sbjct: 598 LATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQ 647
Score = 33.5 bits (75), Expect = 0.13
Identities = 33/133 (24%), Positives = 60/133 (45%), Gaps = 27/133 (20%)
Query: 30 RHRLVVLEKELLRDHLALRR-----DEARRAKASEDQLRQRLQGVEAELEGARSEGKAIY 84
R ++ E+EL + + ++ ++ + S DQ+R+ +EAELE
Sbjct: 724 RAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELE-------KHM 776
Query: 85 AEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQL 144
A S +C + +EV GLR L Q + AA+ EA++ E LA +
Sbjct: 777 AAASAEC-----------QNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDE----LALV 821
Query: 145 RAHMADMEAKYEE 157
R +++M++ E+
Sbjct: 822 RQQLSEMKSHVED 834
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapiens]
Length = 1478
Score = 48.5 bits (114), Expect = 4e-06
Identities = 50/159 (31%), Positives = 70/159 (44%), Gaps = 20/159 (12%)
Query: 37 EKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQE 96
EKE L++ L + A + QL Q Q ++ E A E + ++S +
Sbjct: 957 EKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIM---- 1012
Query: 97 DMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYE 156
D Q+R K EE K LRGQLE R+ AA E A+ +L+A ADM K
Sbjct: 1013 DYQSRLKNAGEECKSLRGQLEEQGRQLQAAEE-----------AVEKLKATQADMGEKLS 1061
Query: 157 EILHDSLDRLLAKLRAIKQQWDGAALR--LHARHKEQQR 193
+ + A LR K +GAALR L KE ++
Sbjct: 1062 CTSNHLAECQAAMLRKDK---EGAALREDLERTQKELEK 1097
Score = 39.7 bits (91), Expect = 0.002
Identities = 36/159 (22%), Positives = 75/159 (47%), Gaps = 20/159 (12%)
Query: 6 KEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQR 65
+E G+K A ++++ +V + +L L KEL L+ D A+AS ++L +
Sbjct: 401 QELGEKLQALERERTKVEEVNRQQSAQLEQLVKEL-----QLKED----ARASLERLVKE 451
Query: 66 LQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAA 125
+ ++ EL G E ++ + +++ + EEE+ LR + + Q E
Sbjct: 452 MAPLQEELSGKGQEADQLWRRL--------QELLAHTSSWEEELAELRREKKQQQEEKEL 503
Query: 126 AREEAE---QALGERDQALAQLRAHMADMEAKYEEILHD 161
+E + L + LAQ+ H++D+E + ++++ D
Sbjct: 504 LEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQD 542
Score = 37.7 bits (86), Expect = 0.007
Identities = 43/168 (25%), Positives = 69/168 (41%), Gaps = 18/168 (10%)
Query: 44 HLALRRDE------ARRAKASEDQL---RQRLQGVEAELEGARSEGKAIYAEMSRQCHAL 94
H ALRR E A+ +A+ D L Q L L A+ + RQ +
Sbjct: 334 HTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQ-EPI 392
Query: 95 QEDMQTRSKQLEEEVKGL---RGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADM 151
D ++L E+++ L R ++E R+ +A E+ + L ++ A A L + +M
Sbjct: 393 PSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEM 452
Query: 152 EAKYEEILH-----DSLDRLLAKLRAIKQQWDGAALRLHARHKEQQRQ 194
EE+ D L R L +L A W+ L K+QQ +
Sbjct: 453 APLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEE 500
Score = 34.7 bits (78), Expect = 0.060
Identities = 27/97 (27%), Positives = 47/97 (48%), Gaps = 5/97 (5%)
Query: 57 ASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQL 116
+ E++LRQ + +E EL+ + + ++ ALQ D Q +Q E ++G L
Sbjct: 609 SQEEELRQANRELEKELQNVVGRNQLLEGKLQ----ALQADYQAL-QQRESAIQGSLASL 663
Query: 117 EACQREAAAAREEAEQALGERDQALAQLRAHMADMEA 153
EA Q ++ E +L +A ++A MA+ EA
Sbjct: 664 EAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEA 700
Score = 33.9 bits (76), Expect = 0.10
Identities = 37/178 (20%), Positives = 72/178 (40%), Gaps = 21/178 (11%)
Query: 22 GADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGK 81
G + + E + + + + + L+ + + +A + +R +EA L R +
Sbjct: 630 GRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKE 689
Query: 82 AIYAEMSR----------QCHALQEDMQTRSKQLEEEVKGLRGQLEACQREA----AAAR 127
A+ A+M+ +C L+E+++ + E + LR CQ++
Sbjct: 690 AMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTA 749
Query: 128 EEAEQALG-----ERDQALAQLRAHMADMEAKYEEI--LHDSLDRLLAKLRAIKQQWD 178
E+ +Q +G E + AQL A +E E+ L + L AK+RA D
Sbjct: 750 EKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQD 807
Score = 30.8 bits (68), Expect = 0.87
Identities = 36/177 (20%), Positives = 79/177 (44%), Gaps = 25/177 (14%)
Query: 28 ESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQG-----VEAELEGARSEGKA 82
+++ R + +++ ++ L++ R K QL+++ + V+ L+ + EG
Sbjct: 796 QAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREG-- 853
Query: 83 IYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQL-------EACQREAAAAREEAEQALG 135
ALQE+ ++Q EEE++ L+ +L E Q E A +E+ +A
Sbjct: 854 ----------ALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANT 903
Query: 136 ERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQWDGAALRLHARHKEQQ 192
+ + Q+ A + E + EE L ++ L A ++ +G ++ +E++
Sbjct: 904 DTAELGIQVCALTVEKE-RVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKE 959
Score = 30.4 bits (67), Expect = 1.1
Identities = 40/157 (25%), Positives = 68/157 (43%), Gaps = 31/157 (19%)
Query: 46 ALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQ------ 99
AL+ + A A+ E++LR LQ ++ + + E + +AE+ Q H D
Sbjct: 854 ALQEERADEAQQREEELRA-LQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQV 912
Query: 100 ---TRSKQLEEE-----VKGLRGQLEACQRE------AAAAREEAEQALGERDQA----- 140
T K+ EE V+ L+ EA RE A ++ +++L E+ +A
Sbjct: 913 CALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAA 972
Query: 141 --LAQLRAHMADMEAK---YEEILHDSLDRLLAKLRA 172
L L+A +A E + +E H L+ L +L A
Sbjct: 973 GSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSA 1009
Score = 28.1 bits (61), Expect = 5.6
Identities = 31/133 (23%), Positives = 57/133 (42%), Gaps = 24/133 (18%)
Query: 49 RDEARRAKASEDQLRQRLQGVEAELEGARS----EGKAIYAEMSRQCHALQEDMQTR--- 101
R E + + E QLR+R+Q ++ E + R+ +G+ + E R A +++++
Sbjct: 236 RLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLV 295
Query: 102 ---------SKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADME 152
++ + VK L+ L+ + AA E+ AL + L L
Sbjct: 296 AELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPL-------- 347
Query: 153 AKYEEILHDSLDR 165
A+ E DSLD+
Sbjct: 348 AQELEATRDSLDK 360
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 48.1 bits (113), Expect = 5e-06
Identities = 39/162 (24%), Positives = 75/162 (46%), Gaps = 13/162 (8%)
Query: 48 RRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEE 107
+ +E +R+ + + RLQ EL E ++I +++SR A + + +QLEE
Sbjct: 1263 KNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEE 1322
Query: 108 EVK---GLRGQLEACQREAAAAR---EEAEQALGERDQALAQLRAHMADMEAKYE----- 156
E K L L++ + + R EE ++ E +AL++ + +A KYE
Sbjct: 1323 ENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQ 1382
Query: 157 --EILHDSLDRLLAKLRAIKQQWDGAALRLHARHKEQQRQFG 196
E L ++ +L +L+ ++Q + + + K +QR G
Sbjct: 1383 RTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQG 1424
Score = 38.9 bits (89), Expect = 0.003
Identities = 38/150 (25%), Positives = 69/150 (46%), Gaps = 10/150 (6%)
Query: 37 EKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQE 96
E +L D L+ + ++KA+ +++ + L+ +E G E + +E++ Q LQ
Sbjct: 1224 EFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQT 1283
Query: 97 DMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQA------LAQLRAHMAD 150
+ S+QLEE+ + + QL ++ EE ++ L E ++A Q H D
Sbjct: 1284 EAGELSRQLEEK-ESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCD 1342
Query: 151 -MEAKYEEILHD--SLDRLLAKLRAIKQQW 177
+ +YEE L R L+K + QW
Sbjct: 1343 LLREQYEEEQEGKAELQRALSKANSEVAQW 1372
Score = 32.3 bits (72), Expect = 0.30
Identities = 49/205 (23%), Positives = 86/205 (41%), Gaps = 34/205 (16%)
Query: 4 KNKEKGKKSGAQKK------------KKNWGADVVAESRHRLVVLEK--ELLRDHLALRR 49
K K++ KS A++K K + V AES + L E+ +L++ L
Sbjct: 859 KTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEA 918
Query: 50 D--EARRAKASEDQLRQRLQGVEAELEGARSEGKA-------IYAEMSRQCHALQEDMQT 100
E E+++ L + +LE SE K A++ ++ HA + +
Sbjct: 919 KIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV-- 976
Query: 101 RSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGE---RDQALAQLRAHMADMEAKYEE 157
K L EE+ GL + RE A +E +QAL + + + L + +E + E+
Sbjct: 977 --KNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVED 1034
Query: 158 ILHDSLD---RLLAKLRAIKQQWDG 179
L SL+ +L L K++ +G
Sbjct: 1035 -LESSLEQEKKLRVDLERNKRKLEG 1058
Score = 30.8 bits (68), Expect = 0.87
Identities = 23/110 (20%), Positives = 51/110 (46%), Gaps = 23/110 (20%)
Query: 70 EAELEGARSEGKAIYAEMSRQCHALQEDM------QTRSKQLEEEVKGL----------- 112
+AELE + E +++ E+ + +A +E + + +K LE+E+ L
Sbjct: 1465 QAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTI 1524
Query: 113 ------RGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYE 156
R Q+E + + A EEAE AL + + +++ + ++++ +
Sbjct: 1525 HELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEID 1574
Score = 30.0 bits (66), Expect = 1.5
Identities = 42/151 (27%), Positives = 73/151 (48%), Gaps = 28/151 (18%)
Query: 16 KKKKNWGADVVAESRHRLVVLEKEL---LRDHLALRRDEARRAKASEDQLRQRLQGVEAE 72
KK++N+ V+AE + + + EL L++ +L + + A E+ L Q L+ V+ E
Sbjct: 1445 KKQRNFDK-VLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQ-LETVKRE 1502
Query: 73 LEGARSE-----------GKAIYA-EMSRQCHALQE-DMQTRSKQLE-----EEVKGLRG 114
+ E GK I+ E SR+ L++ D+Q ++ E EE K LR
Sbjct: 1503 NKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRI 1562
Query: 115 QLEACQREAAAAREEAEQALGERDQALAQLR 145
QLE Q + E ++ + E+D+ + QL+
Sbjct: 1563 QLELTQ-----VKSEIDRKIAEKDEEIEQLK 1588
Score = 27.3 bits (59), Expect = 9.6
Identities = 32/163 (19%), Positives = 68/163 (41%), Gaps = 14/163 (8%)
Query: 38 KELLRDHLALRRDEARRAKASEDQLRQRLQGVEAE---LEGARSEGKAIYAEMSRQCHAL 94
K L L L ++ + + QL +RL+ + E L+ + + + + ++
Sbjct: 1053 KRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKI--- 1109
Query: 95 QEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAK 154
+++Q R ++LEEE++ R +++ + E E+ L ER + + + ++ K
Sbjct: 1110 -KELQARIEELEEEIEAERATRAKTEKQRSDYARELEE-LSERLEEAGGVTSTQIELNKK 1167
Query: 155 YE-EILHDSLDRLLAKLRAIKQQWDGAALRLHARHKEQQRQFG 196
E E L +L L Q + L +H + + G
Sbjct: 1168 REAEFL-----KLRRDLEEATLQHEAMVAALRKKHADSVAELG 1205
>gi|214010165 rab11-family interacting protein 3 isoform 2 [Homo
sapiens]
Length = 460
Score = 47.8 bits (112), Expect = 7e-06
Identities = 41/146 (28%), Positives = 67/146 (45%), Gaps = 8/146 (5%)
Query: 23 ADVVAESRHRLVVLEKELL---RDHLALRRDEAR---RAKASEDQLR-QRLQGVEAELEG 75
AD V R++ LEK+ H LR++ + RA A E+QL+ Q L+ E LE
Sbjct: 167 ADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEE 226
Query: 76 ARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALG 135
R + K + +M R+ E++QTR +QL+EE LR + EE ++ L
Sbjct: 227 TRRQ-KELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLD 285
Query: 136 ERDQALAQLRAHMADMEAKYEEILHD 161
E + +L + + + H+
Sbjct: 286 EIESLTLRLSEEQENKRRMGDRLSHE 311
>gi|7662234 rab11-family interacting protein 3 isoform 1 [Homo
sapiens]
Length = 756
Score = 47.8 bits (112), Expect = 7e-06
Identities = 41/146 (28%), Positives = 67/146 (45%), Gaps = 8/146 (5%)
Query: 23 ADVVAESRHRLVVLEKELL---RDHLALRRDEAR---RAKASEDQLR-QRLQGVEAELEG 75
AD V R++ LEK+ H LR++ + RA A E+QL+ Q L+ E LE
Sbjct: 463 ADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEE 522
Query: 76 ARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALG 135
R + K + +M R+ E++QTR +QL+EE LR + EE ++ L
Sbjct: 523 TRRQ-KELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLD 581
Query: 136 ERDQALAQLRAHMADMEAKYEEILHD 161
E + +L + + + H+
Sbjct: 582 EIESLTLRLSEEQENKRRMGDRLSHE 607
>gi|187607364 tuftelin 1 isoform 2 [Homo sapiens]
Length = 365
Score = 47.4 bits (111), Expect = 9e-06
Identities = 58/215 (26%), Positives = 103/215 (47%), Gaps = 40/215 (18%)
Query: 15 QKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEAR--RAKASEDQLRQRLQGVEAE 72
Q+ K+ +D VA L ++E + ++AL+R+E R + +A +L++RL G+E E
Sbjct: 159 QEAKRQHQSDCVA-FEVTLSRYQREAEQSNVALQREEDRVEQKEAEVGELQRRLLGMETE 217
Query: 73 LEGARS---EGKAIYAEM---SRQCHALQEDMQTRSKQLEEEVKGLR-------GQLEAC 119
+ + EG+ E+ + C A +E T LE+EV GLR L++
Sbjct: 218 HQALLAKVREGEVALEELRSNNADCQAEREKAAT----LEKEVAGLREKIHHLDDMLKSQ 273
Query: 120 QREAAAAREEAEQA---LGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQ 176
QR+ E+ + + + +D + +L+ +A +EA+ E +HD ++ L I++Q
Sbjct: 274 QRKVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLE-MHDRMEHL------IEKQ 326
Query: 177 WDGAALRLHARHKEQQRQFGLTPPGSLR---PPAP 208
AR K + PGS+R PP+P
Sbjct: 327 ISHGNFSTQARAKTEN-------PGSIRISKPPSP 354
>gi|9910596 tuftelin 1 isoform 1 [Homo sapiens]
Length = 390
Score = 47.4 bits (111), Expect = 9e-06
Identities = 58/215 (26%), Positives = 103/215 (47%), Gaps = 40/215 (18%)
Query: 15 QKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEAR--RAKASEDQLRQRLQGVEAE 72
Q+ K+ +D VA L ++E + ++AL+R+E R + +A +L++RL G+E E
Sbjct: 184 QEAKRQHQSDCVA-FEVTLSRYQREAEQSNVALQREEDRVEQKEAEVGELQRRLLGMETE 242
Query: 73 LEGARS---EGKAIYAEM---SRQCHALQEDMQTRSKQLEEEVKGLR-------GQLEAC 119
+ + EG+ E+ + C A +E T LE+EV GLR L++
Sbjct: 243 HQALLAKVREGEVALEELRSNNADCQAEREKAAT----LEKEVAGLREKIHHLDDMLKSQ 298
Query: 120 QREAAAAREEAEQA---LGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQ 176
QR+ E+ + + + +D + +L+ +A +EA+ E +HD ++ L I++Q
Sbjct: 299 QRKVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLE-MHDRMEHL------IEKQ 351
Query: 177 WDGAALRLHARHKEQQRQFGLTPPGSLR---PPAP 208
AR K + PGS+R PP+P
Sbjct: 352 ISHGNFSTQARAKTEN-------PGSIRISKPPSP 379
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 47.0 bits (110), Expect = 1e-05
Identities = 55/218 (25%), Positives = 98/218 (44%), Gaps = 40/218 (18%)
Query: 14 AQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAEL 73
AQ ++ G D +E + + +V + + L R + A A+ +L L+ +EA +
Sbjct: 1567 AQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHI 1626
Query: 74 EGA---RSEG----KAIYAEMSRQC-------HALQEDMQTRSKQLEEEVKGLRGQLEAC 119
+ A R E + + A+M + C A +E++ ++K+ E+++K + ++
Sbjct: 1627 DSANKNRDEAIKQLRKLQAQM-KDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQL 1685
Query: 120 QREAAAAREEAEQALGERDQ------------ALA-----QLRAHMADMEAKYE------ 156
Q E AAA QA ERD+ ALA +L A +A +E + E
Sbjct: 1686 QEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNT 1745
Query: 157 EILHDSLDRLLAKLRAIKQQWDGAALRLHARHKEQQRQ 194
E+++D L + A L+ + D R HA+ E RQ
Sbjct: 1746 ELINDRLKK--ANLQIDQINTDLNLERSHAQKNENARQ 1781
Score = 42.0 bits (97), Expect = 4e-04
Identities = 44/175 (25%), Positives = 84/175 (48%), Gaps = 22/175 (12%)
Query: 7 EKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRL 66
E+ +KS + K KN +H ++ + E LRR+E +R + ++ R++L
Sbjct: 1010 EEEEKSKSLAKLKN---------KHEAMITDLEE-----RLRREEKQRQEL--EKTRRKL 1053
Query: 67 QGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLR---GQLEACQREA 123
+G +L +E +A AE+ Q +E++Q ++EEE ++ + +
Sbjct: 1054 EGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQI 1113
Query: 124 AAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLA--KLRAIKQQ 176
+ +E+ E R++A Q R ++EA E L D+LD A +LR+ ++Q
Sbjct: 1114 SELQEDLESERASRNKAEKQKRDLGEELEALKTE-LEDTLDSTAAQQELRSKREQ 1167
Score = 41.2 bits (95), Expect = 6e-04
Identities = 51/184 (27%), Positives = 86/184 (46%), Gaps = 15/184 (8%)
Query: 25 VVAESR-HRLVVLEKELLRDHLALRRDEARRAK--ASEDQLRQRLQGVEAELEGARSEGK 81
+ AE+R + L+ +L+ + L L+ + A ++LR RL + ELE + +
Sbjct: 862 LAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLE 921
Query: 82 AIYAEMSRQCHAL-------QEDMQTRSKQLEEEVKGLRG-QLEACQREAAAAREEAEQ- 132
A E +C L Q+++Q +QLEEE + QLE EA + E EQ
Sbjct: 922 ARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQI 981
Query: 133 ALGERDQALAQLRAHMADMEAKYEEIL--HDSLDRLLAKLRAIKQQWDGAALRLHARHKE 190
L +++ LA+ + + D A++ L + + LAKL+ K + L R +E
Sbjct: 982 ILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKN-KHEAMITDLEERLRREE 1040
Query: 191 QQRQ 194
+QRQ
Sbjct: 1041 KQRQ 1044
Score = 40.4 bits (93), Expect = 0.001
Identities = 41/173 (23%), Positives = 86/173 (49%), Gaps = 19/173 (10%)
Query: 28 ESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELE---GARSEGKAIY 84
+S H+ +E +L L ++ +E R + +L ++ ++ EL+ G S+ +
Sbjct: 1242 DSEHKRKKVEAQL--QELQVKFNEGERVRT---ELADKVTKLQVELDNVTGLLSQSDSKS 1296
Query: 85 AEMSRQCHALQEDMQTRSKQLEEEVK---GLRGQLEACQREAAAARE---EAEQALGERD 138
+++++ AL+ +Q + L+EE + L +L+ + E + RE E E+A +
Sbjct: 1297 SKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLE 1356
Query: 139 QALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQWDGAALRLHARHKEQ 191
+ +A L A +ADM+ K E+ + L+ R +++ +G L RH+E+
Sbjct: 1357 KQIATLHAQVADMKKKMEDSV-GCLETAEEVKRKLQKDLEG----LSQRHEEK 1404
Score = 39.3 bits (90), Expect = 0.002
Identities = 36/171 (21%), Positives = 75/171 (43%), Gaps = 6/171 (3%)
Query: 28 ESRHRLVVLEKEL--LRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYA 85
E+ +L +E E+ L++ LA R+A+ D+L + + A E + + A
Sbjct: 1670 ENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEA 1729
Query: 86 EMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQ-- 143
+++ L+E+ Q ++ + + +K Q++ + R A++ R Q Q
Sbjct: 1730 RIAQLEEELEEE-QGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNK 1788
Query: 144 -LRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQWDGAALRLHARHKEQQR 193
L+ + +ME + S+ L AK+ +++Q D A K+ +R
Sbjct: 1789 ELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRR 1839
Score = 37.4 bits (85), Expect = 0.009
Identities = 27/128 (21%), Positives = 61/128 (47%), Gaps = 6/128 (4%)
Query: 50 DEARRAKASE-DQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEE 108
++++RA + ++++ +L+ +E EL+ + + + D+Q R +Q EE+
Sbjct: 1524 EKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEK 1583
Query: 109 VKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLA 168
K L Q+ + E R++ A+ R +L + D+EA + + + D +
Sbjct: 1584 KKQLVRQVREMEAELEDERKQRSMAVAAR----KKLEMDLKDLEAHIDS-ANKNRDEAIK 1638
Query: 169 KLRAIKQQ 176
+LR ++ Q
Sbjct: 1639 QLRKLQAQ 1646
Score = 35.4 bits (80), Expect = 0.035
Identities = 41/165 (24%), Positives = 74/165 (44%), Gaps = 12/165 (7%)
Query: 37 EKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSE-GKAIYAEMSRQCHALQ 95
EKE LA +EA KA ++L ++ + +L ++ + GK+++ E+ + AL+
Sbjct: 1473 EKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVH-ELEKSKRALE 1531
Query: 96 EDMQTRSKQLEEEVKGLRGQLEACQR---EAAAAREEAEQALGERD----QALAQLRAHM 148
+ ++ QLEE L+ +A R A + + E+ L RD + QL +
Sbjct: 1532 QQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQV 1591
Query: 149 ADMEAKYEEILHDSLDRLLAKLRAIKQQWDGAALRLHARHKEQQR 193
+MEA+ E+ + R +A K + D L H + R
Sbjct: 1592 REMEAELED---ERKQRSMAVAARKKLEMDLKDLEAHIDSANKNR 1633
Score = 32.7 bits (73), Expect = 0.23
Identities = 26/164 (15%), Positives = 71/164 (43%), Gaps = 13/164 (7%)
Query: 7 EKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRD------------EARR 54
E+ ++ A+K+K++ G ++ A L+ + L +R+ EA+
Sbjct: 1123 ERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKT 1182
Query: 55 AKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRG 114
+A ++RQ+ EL + K + A + + L+ + + +++ ++G +G
Sbjct: 1183 HEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQG-KG 1241
Query: 115 QLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEI 158
E +++ A +E + E ++ +L + ++ + + +
Sbjct: 1242 DSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNV 1285
Score = 31.6 bits (70), Expect = 0.51
Identities = 37/187 (19%), Positives = 76/187 (40%), Gaps = 20/187 (10%)
Query: 15 QKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELE 74
++ ++ G + R + L+ + + L L R A++ + + QL ++ + ++ +L+
Sbjct: 1736 EELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQ 1795
Query: 75 GARSEGKAIY-----------AEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREA 123
K+ Y A++ Q ++ Q KQ+ K L+ L E
Sbjct: 1796 EMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDE- 1854
Query: 124 AAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQWDGAALR 183
R AEQ + D+A +L+ +E EE R A R ++++ + A
Sbjct: 1855 ---RRNAEQYKDQADKASTRLKQLKRQLEEAEEE-----AQRANASRRKLQRELEDATET 1906
Query: 184 LHARHKE 190
A ++E
Sbjct: 1907 ADAMNRE 1913
Score = 30.4 bits (67), Expect = 1.1
Identities = 23/109 (21%), Positives = 47/109 (43%), Gaps = 8/109 (7%)
Query: 28 ESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEM 87
E + + V+L+ + R + +D+A +A QL+++L+ E E + A + + + E+
Sbjct: 1841 EKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL 1900
Query: 88 SRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGE 136
ED + + EV L+ +L R A + G+
Sbjct: 1901 --------EDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGD 1941
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 46.6 bits (109), Expect = 2e-05
Identities = 39/170 (22%), Positives = 73/170 (42%), Gaps = 23/170 (13%)
Query: 50 DEARRAKASEDQLRQ----------RLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQ 99
D+ KA ++Q Q RLQ EL E +++ +++++ AL + ++
Sbjct: 1258 DQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLE 1317
Query: 100 TRSKQLEEEVKGLRGQLEACQRE------AAAAREEAEQALGERDQALAQLRAHMADMEA 153
+Q+EEE K A Q EE ++A E +AL++ + +A
Sbjct: 1318 ELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRT 1377
Query: 154 KYE-------EILHDSLDRLLAKLRAIKQQWDGAALRLHARHKEQQRQFG 196
KYE E L ++ +L +L+ ++ + A + + K +QR G
Sbjct: 1378 KYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQG 1427
Score = 41.6 bits (96), Expect = 5e-04
Identities = 47/205 (22%), Positives = 96/205 (46%), Gaps = 21/205 (10%)
Query: 6 KEKGKKSGAQKKKKNWGADVVAESRHRLVVLE--KELLRDHLALRRDEARRAKASED--- 60
+EK ++ ++ K+ D+ S+ ++ LE K+ + + L + E + +A D
Sbjct: 1044 QEKKLRADLERAKRKLEGDLKM-SQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQ 1102
Query: 61 ----QLRQRLQGVEAELEGARSEGKA---IYAEMSRQCHALQEDMQTRSKQLEEEVKGLR 113
Q +++++ ++A +E E +A + A++ +Q L +++ S++LEE
Sbjct: 1103 VHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATS 1162
Query: 114 GQLEACQREAA---AAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKL 170
Q+E ++ A R + E+A + + A LR AD A+ E + D+L R+ KL
Sbjct: 1163 AQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQI-DNLQRVKQKL 1221
Query: 171 R----AIKQQWDGAALRLHARHKEQ 191
+K + D A + A K +
Sbjct: 1222 EKEKSELKMEIDDMASNIEALSKSK 1246
Score = 39.7 bits (91), Expect = 0.002
Identities = 34/151 (22%), Positives = 71/151 (47%), Gaps = 13/151 (8%)
Query: 36 LEKELLRDHLALRRDEARRAKASE--DQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHA 93
L ++L R H A + ++ + + +Q+L +AELE A+ E +++ E+ + +A
Sbjct: 1432 LMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNA 1491
Query: 94 LQ------EDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAH 147
+ E ++ +K L+EE+ L Q+ E +EAE+ +Q + L+
Sbjct: 1492 YEEVVDQLETLRRENKNLQEEISDLTEQI----AETGKNLQEAEKTKKLVEQEKSDLQVA 1547
Query: 148 MADMEAKYEEILHDSLDRLLAKLRAIKQQWD 178
+ ++E E + R+ +L +K + D
Sbjct: 1548 LEEVEGSLEH-EESKILRVQLELSQVKSELD 1577
Score = 35.8 bits (81), Expect = 0.027
Identities = 42/176 (23%), Positives = 79/176 (44%), Gaps = 21/176 (11%)
Query: 6 KEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQR 65
KE+ + ++ KKN V + +HRL E+ LAL K + Q+ Q+
Sbjct: 1775 KEQDTSAHLERMKKNL-EQTVKDLQHRLDEAEQ------LAL--------KGGKKQI-QK 1818
Query: 66 LQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKG---LRGQLEACQRE 122
L+ ELE + AE + H + ++ + Q EE+ K L+ ++ Q +
Sbjct: 1819 LENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAK 1878
Query: 123 AAAAREEAEQALGERDQALAQLR--AHMADMEAKYEEILHDSLDRLLAKLRAIKQQ 176
+ + +AE+A + + L++ R H + A+ +I +++L AK R + Q
Sbjct: 1879 VKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQ 1934
Score = 32.0 bits (71), Expect = 0.39
Identities = 39/203 (19%), Positives = 82/203 (40%), Gaps = 27/203 (13%)
Query: 16 KKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEG 75
KK++N+ V+AE + +L + EL + E+R ++R + V +LE
Sbjct: 1448 KKQRNFDK-VLAEWKQKLDESQAEL-----EAAQKESRSLSTELFKMRNAYEEVVDQLET 1501
Query: 76 ARSEGKAIYAEMSRQCHALQE--------------------DMQTRSKQLEEEVKGLRGQ 115
R E K + E+S + E D+Q +++E ++ +
Sbjct: 1502 LRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESK 1561
Query: 116 LEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQ 175
+ Q E + + E ++ + E+D+ + QL+ + + +L + LR +K+
Sbjct: 1562 ILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALR-LKK 1620
Query: 176 QWDGAALRLHARHKEQQRQFGLT 198
+ +G + + RQ T
Sbjct: 1621 KMEGDLNEMEIQLGHSNRQMAET 1643
Score = 30.0 bits (66), Expect = 1.5
Identities = 28/154 (18%), Positives = 67/154 (43%), Gaps = 19/154 (12%)
Query: 27 AESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAE 86
AE + + + + ++ + L +D + + + L Q ++ ++ L+ A
Sbjct: 1755 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ-------- 1806
Query: 87 MSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRA 146
+ + + ++LE V+ L +L+ Q+ A A + A + + +
Sbjct: 1807 ------LALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKY-----ERKVKEMT 1855
Query: 147 HMADMEAKYEEILHDSLDRLLAKLRAIKQQWDGA 180
+ A+ + K L D +D+L AK+++ K+Q + A
Sbjct: 1856 YQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEA 1889
Score = 27.3 bits (59), Expect = 9.6
Identities = 45/203 (22%), Positives = 81/203 (39%), Gaps = 56/203 (27%)
Query: 6 KEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQR 65
+E ++ + K KN A + SRH + +LLR+ +E + AKA
Sbjct: 1317 EELKRQMEEETKAKNAMAHALQSSRH-----DCDLLREQY----EEEQEAKA-------- 1359
Query: 66 LQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAA 125
EL+ A S+ + A+ + + D R+++LEE K L +L+
Sbjct: 1360 ------ELQRALSKANSEVAQWRTK---YETDAIQRTEELEEAKKKLAQRLQ-------- 1402
Query: 126 AREEAEQALGERDQALAQLRAHMADMEAKYEEILHD----------------SLDRLLAK 169
EAE+ + A L ++ + E+++ D + D++LA+
Sbjct: 1403 ---EAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAE 1459
Query: 170 LRAIKQQWDGAALRLHARHKEQQ 192
KQ+ D + L A KE +
Sbjct: 1460 W---KQKLDESQAELEAAQKESR 1479
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 46.6 bits (109), Expect = 2e-05
Identities = 47/185 (25%), Positives = 82/185 (44%), Gaps = 15/185 (8%)
Query: 6 KEKGKKSGAQKKKKNWGADV------VAESRHRLVVLEKELLR-----DHLALRRDEARR 54
+EK + ++ K+ D+ VA++ LE++L + L+LR ++ +
Sbjct: 1089 QEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQL 1148
Query: 55 AKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRG 114
A + + LQ ELE +A A + +Q +++ S++LEE G
Sbjct: 1149 LGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAG 1208
Query: 115 QLEACQR---EAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLR 171
Q E C++ E R E E+A + +A LR A+ A+ E + DSL R+ KL
Sbjct: 1209 QREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQV-DSLQRVRQKLE 1267
Query: 172 AIKQQ 176
K +
Sbjct: 1268 KEKSE 1272
Score = 43.9 bits (102), Expect = 1e-04
Identities = 38/160 (23%), Positives = 73/160 (45%), Gaps = 13/160 (8%)
Query: 47 LRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLE 106
++ +E +R A R RLQ EL E + + +++SR + ++ +QLE
Sbjct: 1310 IKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLE 1369
Query: 107 EEVK---GLRGQLEACQREAAAAREEAE---QALGERDQALAQLRAHMADMEAKYE---- 156
EE K L ++A + + RE+ E +A E + L++ A +A +KYE
Sbjct: 1370 EESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAI 1429
Query: 157 ---EILHDSLDRLLAKLRAIKQQWDGAALRLHARHKEQQR 193
E L ++ +L +L+ ++ + A + + K + R
Sbjct: 1430 QRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLR 1469
Score = 42.4 bits (98), Expect = 3e-04
Identities = 44/193 (22%), Positives = 83/193 (43%), Gaps = 24/193 (12%)
Query: 7 EKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRL 66
E+G ++ K A + ++ V LE E A + R + + ++ R++
Sbjct: 1450 EEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQE 1509
Query: 67 QGVEAELEGARSEGKAIYAEMSRQCHALQEDMQT------RSKQLEEEVKGLRGQ----- 115
+ ++ ELE A+ E + + E+ R H +E ++ +K L+EE+ L Q
Sbjct: 1510 EEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSG 1569
Query: 116 ------------LEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSL 163
LE + E AA EEAE AL + +++ ++ ++A+ + L +
Sbjct: 1570 KSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEK- 1628
Query: 164 DRLLAKLRAIKQQ 176
D A LR Q+
Sbjct: 1629 DEECANLRRNHQR 1641
Score = 40.0 bits (92), Expect = 0.001
Identities = 34/171 (19%), Positives = 86/171 (50%), Gaps = 22/171 (12%)
Query: 27 AESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAE 86
AE + + + + ++ + L +D + + + L Q ++ ++A LE A
Sbjct: 1800 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQ-------- 1851
Query: 87 MSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRA 146
A + + ++LE +V+ L +L+A Q++ A EA + + + ++ + +L A
Sbjct: 1852 ------AALRGGKKQVQKLEAKVRELEAELDAEQKKHA----EALKGVRKHERRVKEL-A 1900
Query: 147 HMADMEAKYEEILHDSLDRLLAKLRAIKQQWDGAALRLH---ARHKEQQRQ 194
+ A+ + K + D +D+L +K+++ K+Q++ A + + A++++ Q +
Sbjct: 1901 YQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHE 1951
Score = 37.4 bits (85), Expect = 0.009
Identities = 48/193 (24%), Positives = 87/193 (45%), Gaps = 33/193 (17%)
Query: 6 KEKGKKSGAQKKKKNWGADVVA--ESRHRLVVLEKELLRDHLA----LRRDEARRAKASE 59
K + +K + K KN ++ A ES RL +K L H L+ +E R + ++
Sbjct: 1012 KAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTK 1071
Query: 60 DQLR--QRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSK----------QLEE 107
+LR Q+++ +E LE + K + + R L+ D++ + QLEE
Sbjct: 1072 AKLRLEQQVEDLECSLE----QEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEE 1127
Query: 108 EVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLL 167
++K +L + R E EQ LG AQ++ + +++A+ EE+ +
Sbjct: 1128 KLKKKDSELSQL-----SLRVEDEQLLG------AQMQKKIKELQARAEELEEELEAERA 1176
Query: 168 AKLRAIKQQWDGA 180
A+ R KQ+ + A
Sbjct: 1177 ARARVEKQRAEAA 1189
Score = 37.4 bits (85), Expect = 0.009
Identities = 49/178 (27%), Positives = 79/178 (44%), Gaps = 16/178 (8%)
Query: 24 DVVAESRHRLVVLEKELLRD--HLALRRDEARRAKASEDQLRQRLQGVEAELEGA-RSEG 80
D +R+ + L+K++ D L L+ A R +A+E Q RL + + E A R E
Sbjct: 1651 DAETRARNEALRLKKKMEGDLNDLELQLGHATR-QATEAQAATRLMQAQLKEEQAGRDEE 1709
Query: 81 KAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQAL------ 134
+ + AE+ Q AL+ R+ L E++ LR LE +R A +E +A
Sbjct: 1710 QRLAAELHEQAQALER----RASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLL 1765
Query: 135 -GERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQWDGAALRLHARHKEQ 191
+ L Q + AD+ E+ + +R A+ +A K D AA+ KEQ
Sbjct: 1766 HSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITD-AAMMAEELKKEQ 1822
Score = 32.7 bits (73), Expect = 0.23
Identities = 27/92 (29%), Positives = 45/92 (48%), Gaps = 2/92 (2%)
Query: 101 RSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILH 160
RS Q EEE+ LR +L R A AA E Q L E ++ Q + +A ++ L
Sbjct: 890 RSAQAEEELAALRAELRGL-RGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLA 948
Query: 161 DSLDRLLAKLRAIKQQWDGAALRLHARHKEQQ 192
D+ +R +++ K Q +G L R ++++
Sbjct: 949 DAEERCHLLIKS-KVQLEGKVKELSERLEDEE 979
Score = 30.8 bits (68), Expect = 0.87
Identities = 35/144 (24%), Positives = 60/144 (41%), Gaps = 17/144 (11%)
Query: 27 AESRHRLVVLEKELLRD---HLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAI 83
AE R L++ K L L+ R ++ A R++L+ EL+ + K
Sbjct: 950 AEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLT 1009
Query: 84 YAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALG----ERDQ 139
A+ ++ A + + K L EE+ L + +E A +E +QALG E D+
Sbjct: 1010 LAKAEKEKQATENKV----KNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDR 1065
Query: 140 ALA------QLRAHMADMEAKYEE 157
A +L + D+E E+
Sbjct: 1066 VSALTKAKLRLEQQVEDLECSLEQ 1089
Score = 28.1 bits (61), Expect = 5.6
Identities = 35/163 (21%), Positives = 61/163 (37%), Gaps = 23/163 (14%)
Query: 51 EARRAKASEDQLRQRLQGVEAELEGA-----------RSEGKAIYAEMSRQCHALQEDMQ 99
E + K + + + +Q E EGA + E + AE+ R+ E+
Sbjct: 1574 ELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECA 1633
Query: 100 TRSKQLEEEVKGLRGQLEA---CQREAAAAREEAEQALGE---------RDQALAQLRAH 147
+ + V+ L+ L+A + EA +++ E L + R AQ
Sbjct: 1634 NLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATR 1693
Query: 148 MADMEAKYEEILHDSLDRLLAKLRAIKQQWDGAALRLHARHKE 190
+ + K E+ D RL A+L Q + A L A +E
Sbjct: 1694 LMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEE 1736
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 46.2 bits (108), Expect = 2e-05
Identities = 48/209 (22%), Positives = 89/209 (42%), Gaps = 25/209 (11%)
Query: 5 NKEKGKKSGAQKKKKNWGADVV------AESRHRLVVLEKELLRDHLALRRDEARRAKAS 58
N EK K+ G + K +V AES H+ L+ ++ H + + R + +
Sbjct: 1221 NLEKNKQ-GLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELA 1279
Query: 59 E--DQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRG-- 114
E +L+ L V LE A +G + ++ +L+ +Q + L+EE +
Sbjct: 1280 EKASKLQNELDNVSTLLEEAEKKG----IKFAKDAASLESQLQDTQELLQEETRQKLNLS 1335
Query: 115 ----QLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYE------EILHDSLD 164
QLE + +EE E+A ++ + L++ +AD + K + E L ++
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395
Query: 165 RLLAKLRAIKQQWDGAALRLHARHKEQQR 193
+LL A+ Q+ + AL K + R
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNR 1424
Score = 44.3 bits (103), Expect = 8e-05
Identities = 44/209 (21%), Positives = 87/209 (41%), Gaps = 46/209 (22%)
Query: 28 ESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEM 87
E + RL++ + L L R + A AS+ ++ L+ +EA++E A + ++
Sbjct: 1588 EEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQL 1647
Query: 88 SR-------------QCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQAL 134
+ + A ++++ +SK+ E+++K L ++ Q E A++ A
Sbjct: 1648 RKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAE 1707
Query: 135 GERDQAL-----------------AQLRAHMADMEAKYEE----------------ILHD 161
ERD+ +L A +A +E + EE + D
Sbjct: 1708 QERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVD 1767
Query: 162 SLDRLLAKLRAIKQQWDGAALRLHARHKE 190
+L+ LA R+ Q+ D A +L ++KE
Sbjct: 1768 TLNAELAAERSAAQKSDNARQQLERQNKE 1796
Score = 42.7 bits (99), Expect = 2e-04
Identities = 36/152 (23%), Positives = 67/152 (44%), Gaps = 24/152 (15%)
Query: 49 RDEARRAKASEDQLRQRLQGVEAELEGARSEGK----------AIYAEMSRQCHALQEDM 98
+D+ +A D+L+ +L E EL+GA + G + E+ Q LQED
Sbjct: 1068 QDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDF 1127
Query: 99 QT----------RSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHM 148
++ + + L EE++ L+ +LE AA +E +R+Q +A+L+ +
Sbjct: 1128 ESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQE----LRTKREQEVAELKKAL 1183
Query: 149 ADMEAKYEEILHDSLDRLLAKLRAIKQQWDGA 180
+ +E + D R L + +Q + A
Sbjct: 1184 EEETKNHEAQIQDMRQRHATALEELSEQLEQA 1215
Score = 41.2 bits (95), Expect = 6e-04
Identities = 42/167 (25%), Positives = 78/167 (46%), Gaps = 15/167 (8%)
Query: 37 EKELLRDHLALRRDEARRAKA------SEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQ 90
+K+LL+D AL + +A A ++++L+Q L + +L+ R + + +
Sbjct: 1394 KKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKF 1453
Query: 91 CHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAA-----AREEAEQALGERDQALAQLR 145
L E+ ++ EE R + EA ++E A A EEA +A E ++ QLR
Sbjct: 1454 DQLLAEEKSISARYAEERD---RAEAEAREKETKALSLARALEEALEAKEEFERQNKQLR 1510
Query: 146 AHMADMEAKYEEILHDSLDRLLAKLRAIKQQWDGAALRLHARHKEQQ 192
A M D+ + +++ ++ L RA++QQ + +L E Q
Sbjct: 1511 ADMEDLMSSKDDV-GKNVHELEKSKRALEQQVEEMRTQLEELEDELQ 1556
Score = 40.0 bits (92), Expect = 0.001
Identities = 38/190 (20%), Positives = 85/190 (44%), Gaps = 25/190 (13%)
Query: 7 EKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRD---------------- 50
E+ ++ A+ ++K A +A + + ++E R + LR D
Sbjct: 1469 EERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVH 1528
Query: 51 ---EARRAKASE-DQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLE 106
+++RA + +++R +L+ +E EL+ + M + D+QTR +Q E
Sbjct: 1529 ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNE 1588
Query: 107 EEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRL 166
E+ + L Q+ + E R++ A+ + ++ + D+EA+ E + + D +
Sbjct: 1589 EKKRLLIKQVRELEAELEDERKQRALAVASK----KKMEIDLKDLEAQI-EAANKARDEV 1643
Query: 167 LAKLRAIKQQ 176
+ +LR ++ Q
Sbjct: 1644 IKQLRKLQAQ 1653
Score = 38.1 bits (87), Expect = 0.005
Identities = 37/168 (22%), Positives = 80/168 (47%), Gaps = 22/168 (13%)
Query: 30 RHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSR 89
R R L+ + L LA R A+++ + QL ++ + ++A+L+ EG
Sbjct: 1758 RFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQ--ELEG--------- 1806
Query: 90 QCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMA 149
A++ + LE ++ L QLE +E AAA + + ++ L ++ +
Sbjct: 1807 ---AVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRT----EKKLKEIFMQVE 1859
Query: 150 DMEAKYEEILHDSLDRLLAKLRAIKQQWDGA---ALRLHARHKEQQRQ 194
D E ++ + + +++ A+++ +K+Q + A A R +A ++ QR+
Sbjct: 1860 D-ERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRE 1906
Score = 37.4 bits (85), Expect = 0.009
Identities = 47/206 (22%), Positives = 85/206 (41%), Gaps = 27/206 (13%)
Query: 15 QKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRD---EARRAKASEDQLRQRLQGVEA 71
+K+ K G E +H+ ++ EK +L + L + EA +A +Q L+ +
Sbjct: 866 EKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILH 925
Query: 72 ELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRG--QLEACQREAAAAREE 129
+LE E + + + +Q +Q +QL+EE +G R QLE EA + E
Sbjct: 926 DLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEE-EGARQKLQLEKVTAEAKIKKME 984
Query: 130 AEQALGE------------RDQALAQLRAHMADMEAK---------YEEILHDSLDRLLA 168
E L E + +A+ + +A+ E K +E++ L+ L
Sbjct: 985 EEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLK 1044
Query: 169 KLRAIKQQWDGAALRLHARHKEQQRQ 194
K +Q+ + A +L + Q Q
Sbjct: 1045 KEEKTRQELEKAKRKLDGETTDLQDQ 1070
Score = 35.0 bits (79), Expect = 0.046
Identities = 43/181 (23%), Positives = 81/181 (44%), Gaps = 26/181 (14%)
Query: 17 KKKNWGADVVAESRHRLVVLEKEL-----LRDHLALRRDEARRAKASEDQLRQRLQGVEA 71
K+K D +AE +L E++ +R+ + + E++ RQ L+ +
Sbjct: 999 KEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKR 1058
Query: 72 ELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKG--LRGQLEA----------- 118
+L+G ++ + AE+ Q ++++ + + EEE++G RG E
Sbjct: 1059 KLDGETTDLQDQIAELQAQI----DELKLQLAKKEEELQGALARGDDETLHKNNALKVVR 1114
Query: 119 -CQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLA--KLRAIKQ 175
Q + A +E+ E R++A Q R ++EA E L D+LD A +LR ++
Sbjct: 1115 ELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTE-LEDTLDTTAAQQELRTKRE 1173
Query: 176 Q 176
Q
Sbjct: 1174 Q 1174
Score = 34.7 bits (78), Expect = 0.060
Identities = 34/125 (27%), Positives = 61/125 (48%), Gaps = 27/125 (21%)
Query: 48 RRDEARRAKASED-QLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLE 106
R++E +AK E +++++ VE ELE EM R+ L E+ ++QL+
Sbjct: 849 RQEEELQAKDEELLKVKEKQTKVEGELE-----------EMERKHQQLLEEKNILAEQLQ 897
Query: 107 EEVKGLRGQLEACQREAAAAREEAEQALG----------ERDQALA----QLRAHMADME 152
E + L + E + AA ++E E+ L ER+Q L +++AH+ D+E
Sbjct: 898 AETE-LFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLE 956
Query: 153 AKYEE 157
+ +E
Sbjct: 957 EQLDE 961
Score = 33.1 bits (74), Expect = 0.18
Identities = 24/81 (29%), Positives = 43/81 (53%), Gaps = 9/81 (11%)
Query: 95 QEDMQTRSKQL---EEEVKGLRGQLEACQREAAAAREE----AEQALGERD--QALAQLR 145
+E++Q + ++L +E+ + G+LE +R+ EE AEQ E + ++R
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMR 910
Query: 146 AHMADMEAKYEEILHDSLDRL 166
A +A + + EEILHD R+
Sbjct: 911 ARLAAKKQELEEILHDLESRV 931
Score = 27.7 bits (60), Expect = 7.4
Identities = 19/89 (21%), Positives = 41/89 (46%), Gaps = 8/89 (8%)
Query: 28 ESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEM 87
E + + + ++ E R H +++ +A A QL+++L+ E E A + + + E+
Sbjct: 1848 EKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQREL 1907
Query: 88 SRQCHALQEDMQTRSKQLEEEVKGLRGQL 116
+D ++ L EV L+ +L
Sbjct: 1908 --------DDATEANEGLSREVSTLKNRL 1928
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 45.1 bits (105), Expect = 4e-05
Identities = 39/169 (23%), Positives = 76/169 (44%), Gaps = 16/169 (9%)
Query: 41 LRDHLALRRDEARRAKASEDQL---RQRLQGVEAELEGARSEGKAIYAEMSRQCHALQED 97
L D + R +A + S + L R +LQ EL E +A+ ++++R +
Sbjct: 1252 LEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQ 1311
Query: 98 MQTRSKQLEEEVK---GLRGQLEACQREAAAAREEAE---QALGERDQALAQLRAHMADM 151
++ +QLEEEVK L L++ + + RE+ E +A E + L++ + +A
Sbjct: 1312 LEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQW 1371
Query: 152 EAKYE-------EILHDSLDRLLAKLRAIKQQWDGAALRLHARHKEQQR 193
KYE E L ++ +L +L+ ++ + + + K + R
Sbjct: 1372 RTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHR 1420
Score = 39.3 bits (90), Expect = 0.002
Identities = 43/193 (22%), Positives = 85/193 (44%), Gaps = 43/193 (22%)
Query: 7 EKGKKSGAQKKKK--------NWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKAS 58
E+ KK AQ+ ++ N + +++HRL ++L+ D + R A A
Sbjct: 1387 EEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVD---VERSNAAAAALD 1443
Query: 59 EDQL---------RQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQ------TRSK 103
+ Q +Q+ + ++ELE ++ E +++ E+ + +A +E ++ +K
Sbjct: 1444 KKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENK 1503
Query: 104 QLEEEVKGL-----------------RGQLEACQREAAAAREEAEQALGERDQALAQLRA 146
L+EE+ L R QLEA + E +A EEAE +L + + + +
Sbjct: 1504 NLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQL 1563
Query: 147 HMADMEAKYEEIL 159
++A+ E L
Sbjct: 1564 EFNQIKAEIERKL 1576
Score = 30.4 bits (67), Expect = 1.1
Identities = 34/150 (22%), Positives = 67/150 (44%), Gaps = 13/150 (8%)
Query: 7 EKGKKSGAQKKKKNWGADV---VAESRHRLVVLEKELLR--DHLALRRDEARRAKASEDQ 61
E+GK AQ + A++ +AE + ++ LR D L D R++ +
Sbjct: 1554 EEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALR 1613
Query: 62 LRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKG---LRGQLEA 118
++++++G E+E S + AE +Q +LQ ++ QL++ V+ L+ +
Sbjct: 1614 VKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1673
Query: 119 CQREAAAAREEAEQALG-----ERDQALAQ 143
+R + E E+ ER + LA+
Sbjct: 1674 VERRNNLLQAELEELRAVVEQTERSRKLAE 1703
Score = 29.3 bits (64), Expect = 2.5
Identities = 36/166 (21%), Positives = 66/166 (39%), Gaps = 20/166 (12%)
Query: 38 KELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQED 97
K L L L ++ + + QL +RL+ + EL A+ A + + AL
Sbjct: 1052 KRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELN-------ALNARIEDE-QALGSQ 1103
Query: 98 MQTRSKQLEEEVKGLRGQLEACQREAAAAREEAE-------QALGERDQALAQLRAHMAD 150
+Q + K+L+ ++ L +LEA +R A A E+ + + ER + + +
Sbjct: 1104 LQKKLKELQARIEELEEELEA-ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIE 1162
Query: 151 MEAKYEEILHDSLDRLLAKLRAIKQQWDGAALRLHARHKEQQRQFG 196
M K E ++ L Q + A L +H + + G
Sbjct: 1163 MNKKREA----EFQKMRRDLEEATLQHEATAAALRKKHADSVAELG 1204
Score = 29.3 bits (64), Expect = 2.5
Identities = 36/149 (24%), Positives = 64/149 (42%), Gaps = 8/149 (5%)
Query: 37 EKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQE 96
E +L D + ++ +AKA+ +++ + L+ E E + +++ Q LQ
Sbjct: 1223 EFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQT 1282
Query: 97 DMQTRSKQLEEEVKGL----RGQLEACQREAAAAR--EEAEQALGERDQALAQLRAHMAD 150
+ S+QL+E+ + RG+L Q+ R EE +A AL R
Sbjct: 1283 ENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDL 1342
Query: 151 MEAKYEEILH--DSLDRLLAKLRAIKQQW 177
+ +YEE L R+L+K + QW
Sbjct: 1343 LREQYEEETEAKAELQRVLSKANSEVAQW 1371
Score = 28.9 bits (63), Expect = 3.3
Identities = 36/151 (23%), Positives = 63/151 (41%), Gaps = 23/151 (15%)
Query: 24 DVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKA- 82
D +A++ R L K ++ L + E E+++ L + +LE SE K
Sbjct: 896 DNLADAEERCDQLIKNKIQ--LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRD 953
Query: 83 ------IYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQAL-- 134
A++ ++ HA + + K L EE+ GL + +E A +E +QAL
Sbjct: 954 IDDLELTLAKVEKEKHATENKV----KNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDD 1009
Query: 135 --GERD------QALAQLRAHMADMEAKYEE 157
E D +A +L + D+E E+
Sbjct: 1010 LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQ 1040
Score = 27.3 bits (59), Expect = 9.6
Identities = 28/104 (26%), Positives = 49/104 (47%), Gaps = 17/104 (16%)
Query: 61 QLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEE-------EVKGLR 113
+++ L+ E E E A ++ E +R AL++ + R K+LEE E L+
Sbjct: 835 KIKPLLKSAEREKEMA-----SMKEEFTRLKEALEKS-EARRKELEEKMVSLLQEKNDLQ 888
Query: 114 GQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYEE 157
Q++A Q A A E +Q + + QL A + +M + E+
Sbjct: 889 LQVQAEQDNLADAEERCDQLIKNK----IQLEAKVKEMNERLED 928
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 45.1 bits (105), Expect = 4e-05
Identities = 40/135 (29%), Positives = 67/135 (49%), Gaps = 8/135 (5%)
Query: 47 LRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLE 106
LR++E R + ++L++RL G +EL+ E + E+ Q +E++Q + E
Sbjct: 1068 LRKEEKGRQEL--EKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE 1125
Query: 107 EEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEI---LHDSL 163
+E G R QL REA AA EA++ L A + D+ + E + L D+L
Sbjct: 1126 DE-GGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTL 1184
Query: 164 DRLLA--KLRAIKQQ 176
D A +LR+ ++Q
Sbjct: 1185 DSTNAQQELRSKREQ 1199
Score = 43.9 bits (102), Expect = 1e-04
Identities = 44/189 (23%), Positives = 79/189 (41%), Gaps = 38/189 (20%)
Query: 39 ELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDM 98
EL + R + RA+A + QR Q + GA +E ++ +S++ + + +
Sbjct: 1283 ELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQL 1342
Query: 99 QTRSKQLEEEVKG---LRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADME--- 152
+ L+EE + L ++ A + EAA RE+ E+ R++A +L+ A +
Sbjct: 1343 HDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWR 1402
Query: 153 --------------------AKYEEIL-------HDSLDRLLAKLRAIKQQWDGAALRLH 185
A+ E L +++DRL R ++Q+ D A + L
Sbjct: 1403 RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDL- 1461
Query: 186 ARHKEQQRQ 194
EQQRQ
Sbjct: 1462 ----EQQRQ 1466
Score = 41.2 bits (95), Expect = 6e-04
Identities = 55/203 (27%), Positives = 84/203 (41%), Gaps = 34/203 (16%)
Query: 26 VAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLR-----QRLQGVEAELEGARSEG 80
V E + R+ LE+E R LR + A+A E + R Q L+ V +ELE E
Sbjct: 900 VGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEE 959
Query: 81 KAIYAEMSRQCHALQEDMQTRSKQLE-EEVKGLRGQLEACQREAAAAREEAEQALGE--- 136
+ +M + LQ+ +Q LE EE + QLE EA + E + L E
Sbjct: 960 EECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQN 1019
Query: 137 ---------RDQALAQLRAHMADME----------AKYEEILHDSLDRL------LAKLR 171
+ LA+ + A+ E KYE + D DRL +L
Sbjct: 1020 SKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELE 1079
Query: 172 AIKQQWDGAALRLHARHKEQQRQ 194
+K++ DG + L + EQQ++
Sbjct: 1080 KLKRRLDGESSELQEQMVEQQQR 1102
Score = 40.8 bits (94), Expect = 8e-04
Identities = 46/195 (23%), Positives = 83/195 (42%), Gaps = 37/195 (18%)
Query: 15 QKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELE 74
Q ++ G D E R R + + LRD + RDE R+ + R++L+G EL+
Sbjct: 1600 QHERDLQGRDEAGEERRRQLAKQ---LRD-AEVERDEERKQRTLAVAARKKLEGELEELK 1655
Query: 75 GARSEGKAIYAEMSRQCHALQEDMQ-----------------TRSKQLEEEVKGLRGQLE 117
+ E +Q +Q M+ +++++ E+ +KGL ++
Sbjct: 1656 AQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVL 1715
Query: 118 ACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQW 177
Q E AA+ QA +RD+ MAD E+ + +L + A + K+Q
Sbjct: 1716 RLQEELAASDRARRQAQQDRDE--------MAD------EVANGNLSK--AAILEEKRQL 1759
Query: 178 DGAALRLHARHKEQQ 192
+G +L +E+Q
Sbjct: 1760 EGRLGQLEEELEEEQ 1774
Score = 40.4 bits (93), Expect = 0.001
Identities = 48/218 (22%), Positives = 86/218 (39%), Gaps = 40/218 (18%)
Query: 15 QKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAEL- 73
+++++ GA E R E E L LA + + R + +L+Q L +L
Sbjct: 1403 RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLE 1462
Query: 74 ----------------------------------EGARSEGKAIYAEMSRQCHALQEDMQ 99
E A +EG+ A AL+E+ +
Sbjct: 1463 QQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQE 1522
Query: 100 TRSKQLEEEVKGLRGQLEA---CQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYE 156
R ++LE + + LR +LEA + + + E E+A +QA LRA + ++E +
Sbjct: 1523 AR-EELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDEL- 1580
Query: 157 EILHDSLDRLLAKLRAIKQQWDGAALRLHARHKEQQRQ 194
D+ RL ++A+K Q + +E++RQ
Sbjct: 1581 TAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQ 1618
Score = 38.9 bits (89), Expect = 0.003
Identities = 42/138 (30%), Positives = 64/138 (46%), Gaps = 25/138 (18%)
Query: 45 LALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQ 104
LA + ++ARR K + ++ R L+ +EL AE+S A QE Q R ++
Sbjct: 1233 LAEQLEQARRGKGAWEKTRLALEAEVSELR----------AELSSLQTARQEGEQRR-RR 1281
Query: 105 LE---EEVKGLRGQLEACQREAA-------AAREEAEQALGERDQALAQLRAHMADMEAK 154
LE +EV+G G E + EAA A E AL E + +L ++ EA+
Sbjct: 1282 LELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ 1341
Query: 155 YEEILHDSLDRLLAKLRA 172
LHD+ + L + RA
Sbjct: 1342 ----LHDAQELLQEETRA 1355
Score = 38.5 bits (88), Expect = 0.004
Identities = 38/132 (28%), Positives = 61/132 (46%), Gaps = 14/132 (10%)
Query: 32 RLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQC 91
RL K LL+ R+DE +A+A E Q Q LQ A G E + A++ +
Sbjct: 861 RLFTKVKPLLQ---VTRQDEVLQARAQELQKVQELQQQSAREVG---ELQGRVAQLEEER 914
Query: 92 HALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQ-------L 144
L E ++ + +L E + RG+L A ++E E E +GE ++ Q L
Sbjct: 915 ARLAEQLRAEA-ELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRL 973
Query: 145 RAHMADMEAKYE 156
+ H+ ++EA E
Sbjct: 974 QQHIQELEAHLE 985
Score = 36.6 bits (83), Expect = 0.016
Identities = 52/200 (26%), Positives = 91/200 (45%), Gaps = 21/200 (10%)
Query: 4 KNKEKGKKSGAQKKKKNWGADVVAESRHRLVVLEK--ELLRDHLALRRDEARRAKA-SED 60
+ +EKG++ + K++ G +E + ++V ++ E LR L + +E + A A +ED
Sbjct: 1069 RKEEKGRQELEKLKRRLDGES--SELQEQMVEQQQRAEELRAQLGRKEEELQAALARAED 1126
Query: 61 QLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQ---LEEEVKGLRGQLE 117
+ G A+L + E +A AE + + KQ L EE++ LRG+LE
Sbjct: 1127 E-----GGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELE 1181
Query: 118 ACQREAAAARE---EAEQALGERDQAL-AQLRAHMA---DMEAKYEEILHDSLDRLLAKL 170
A +E + EQ + E + L + R H A ++ ++ + L + L L +
Sbjct: 1182 DTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE-LAEQLEQA 1240
Query: 171 RAIKQQWDGAALRLHARHKE 190
R K W+ L L A E
Sbjct: 1241 RRGKGAWEKTRLALEAEVSE 1260
Score = 32.7 bits (73), Expect = 0.23
Identities = 31/121 (25%), Positives = 51/121 (42%), Gaps = 22/121 (18%)
Query: 27 AESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAE 86
AE R + VVL+ E R RD+ + QL+++L+ E E A++ + + E
Sbjct: 1872 AEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRE 1931
Query: 87 MSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQ--------------REAAAAREEAEQ 132
+ ED+ ++ + EV LR +L E A+ EEAE+
Sbjct: 1932 L--------EDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEE 1983
Query: 133 A 133
A
Sbjct: 1984 A 1984
Score = 32.0 bits (71), Expect = 0.39
Identities = 34/147 (23%), Positives = 61/147 (41%), Gaps = 9/147 (6%)
Query: 52 ARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKG 111
++ K ED+L + E E +S K + + A DM+ R L +E KG
Sbjct: 1023 SKERKLLEDRLAEFSSQAAEEEEKVKSLNK-----LRLKYEATIADMEDR---LRKEEKG 1074
Query: 112 LRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLR 171
R +LE +R E ++ + E+ Q +LRA + E + + L + D A+ +
Sbjct: 1075 -RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQ 1133
Query: 172 AIKQQWDGAALRLHARHKEQQRQFGLT 198
+K + A A+ + + T
Sbjct: 1134 LLKSLREAQAALAEAQEDLESERVART 1160
Score = 32.0 bits (71), Expect = 0.39
Identities = 28/120 (23%), Positives = 55/120 (45%), Gaps = 10/120 (8%)
Query: 41 LRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQT 100
L D L D R + + L+ + E +L+G G+ ++++Q + +
Sbjct: 1576 LEDELTAAEDAKLRLEVTVQALKTQH---ERDLQGRDEAGEERRRQLAKQLRDAEVERDE 1632
Query: 101 RSKQLEEEV---KGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYEE 157
KQ V K L G+LE + + A+A + E+A+ + L +++A M ++ + EE
Sbjct: 1633 ERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAV----KQLRKMQAQMKELWREVEE 1688
Score = 29.6 bits (65), Expect = 1.9
Identities = 50/220 (22%), Positives = 89/220 (40%), Gaps = 47/220 (21%)
Query: 16 KKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEAR-----RAKASEDQLRQRLQ--- 67
+KK+ ++AE + ++ +E R R EAR RA E + R+ L+
Sbjct: 1472 EKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQN 1531
Query: 68 -GVEAELEGARSE----GKAIYAEMSRQCHALQE---DMQTRSKQLEEEV---------- 109
+ AELE S GK+++ E+ R C ++ D++ + +LE+E+
Sbjct: 1532 RALRAELEALLSSKDDVGKSVH-ELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRL 1590
Query: 110 ------------KGLRGQLEACQ---REAAAAREEAEQALGERDQALAQLRAHMADMEAK 154
+ L+G+ EA + R+ A +AE E + A +E +
Sbjct: 1591 EVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGE 1650
Query: 155 YEEILHDSLDRLLAKLRAIKQQWDGAALRLHARHKEQQRQ 194
EE+ K A+KQ ++ A+ KE R+
Sbjct: 1651 LEELKAQMASAGQGKEEAVKQ-----LRKMQAQMKELWRE 1685
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 45.1 bits (105), Expect = 4e-05
Identities = 40/135 (29%), Positives = 67/135 (49%), Gaps = 8/135 (5%)
Query: 47 LRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLE 106
LR++E R + ++L++RL G +EL+ E + E+ Q +E++Q + E
Sbjct: 1060 LRKEEKGRQEL--EKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE 1117
Query: 107 EEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEI---LHDSL 163
+E G R QL REA AA EA++ L A + D+ + E + L D+L
Sbjct: 1118 DE-GGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTL 1176
Query: 164 DRLLA--KLRAIKQQ 176
D A +LR+ ++Q
Sbjct: 1177 DSTNAQQELRSKREQ 1191
Score = 43.9 bits (102), Expect = 1e-04
Identities = 44/189 (23%), Positives = 79/189 (41%), Gaps = 38/189 (20%)
Query: 39 ELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDM 98
EL + R + RA+A + QR Q + GA +E ++ +S++ + + +
Sbjct: 1275 ELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQL 1334
Query: 99 QTRSKQLEEEVKG---LRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADME--- 152
+ L+EE + L ++ A + EAA RE+ E+ R++A +L+ A +
Sbjct: 1335 HDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWR 1394
Query: 153 --------------------AKYEEIL-------HDSLDRLLAKLRAIKQQWDGAALRLH 185
A+ E L +++DRL R ++Q+ D A + L
Sbjct: 1395 RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDL- 1453
Query: 186 ARHKEQQRQ 194
EQQRQ
Sbjct: 1454 ----EQQRQ 1458
Score = 41.2 bits (95), Expect = 6e-04
Identities = 55/203 (27%), Positives = 84/203 (41%), Gaps = 34/203 (16%)
Query: 26 VAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLR-----QRLQGVEAELEGARSEG 80
V E + R+ LE+E R LR + A+A E + R Q L+ V +ELE E
Sbjct: 892 VGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEE 951
Query: 81 KAIYAEMSRQCHALQEDMQTRSKQLE-EEVKGLRGQLEACQREAAAAREEAEQALGE--- 136
+ +M + LQ+ +Q LE EE + QLE EA + E + L E
Sbjct: 952 EECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQN 1011
Query: 137 ---------RDQALAQLRAHMADME----------AKYEEILHDSLDRL------LAKLR 171
+ LA+ + A+ E KYE + D DRL +L
Sbjct: 1012 SKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELE 1071
Query: 172 AIKQQWDGAALRLHARHKEQQRQ 194
+K++ DG + L + EQQ++
Sbjct: 1072 KLKRRLDGESSELQEQMVEQQQR 1094
Score = 40.8 bits (94), Expect = 8e-04
Identities = 46/195 (23%), Positives = 83/195 (42%), Gaps = 37/195 (18%)
Query: 15 QKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELE 74
Q ++ G D E R R + + LRD + RDE R+ + R++L+G EL+
Sbjct: 1592 QHERDLQGRDEAGEERRRQLAKQ---LRD-AEVERDEERKQRTLAVAARKKLEGELEELK 1647
Query: 75 GARSEGKAIYAEMSRQCHALQEDMQ-----------------TRSKQLEEEVKGLRGQLE 117
+ E +Q +Q M+ +++++ E+ +KGL ++
Sbjct: 1648 AQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVL 1707
Query: 118 ACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQW 177
Q E AA+ QA +RD+ MAD E+ + +L + A + K+Q
Sbjct: 1708 RLQEELAASDRARRQAQQDRDE--------MAD------EVANGNLSK--AAILEEKRQL 1751
Query: 178 DGAALRLHARHKEQQ 192
+G +L +E+Q
Sbjct: 1752 EGRLGQLEEELEEEQ 1766
Score = 40.4 bits (93), Expect = 0.001
Identities = 48/218 (22%), Positives = 86/218 (39%), Gaps = 40/218 (18%)
Query: 15 QKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAEL- 73
+++++ GA E R E E L LA + + R + +L+Q L +L
Sbjct: 1395 RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLE 1454
Query: 74 ----------------------------------EGARSEGKAIYAEMSRQCHALQEDMQ 99
E A +EG+ A AL+E+ +
Sbjct: 1455 QQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQE 1514
Query: 100 TRSKQLEEEVKGLRGQLEA---CQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYE 156
R ++LE + + LR +LEA + + + E E+A +QA LRA + ++E +
Sbjct: 1515 AR-EELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDEL- 1572
Query: 157 EILHDSLDRLLAKLRAIKQQWDGAALRLHARHKEQQRQ 194
D+ RL ++A+K Q + +E++RQ
Sbjct: 1573 TAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQ 1610
Score = 38.9 bits (89), Expect = 0.003
Identities = 42/138 (30%), Positives = 64/138 (46%), Gaps = 25/138 (18%)
Query: 45 LALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQ 104
LA + ++ARR K + ++ R L+ +EL AE+S A QE Q R ++
Sbjct: 1225 LAEQLEQARRGKGAWEKTRLALEAEVSELR----------AELSSLQTARQEGEQRR-RR 1273
Query: 105 LE---EEVKGLRGQLEACQREAA-------AAREEAEQALGERDQALAQLRAHMADMEAK 154
LE +EV+G G E + EAA A E AL E + +L ++ EA+
Sbjct: 1274 LELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ 1333
Query: 155 YEEILHDSLDRLLAKLRA 172
LHD+ + L + RA
Sbjct: 1334 ----LHDAQELLQEETRA 1347
Score = 38.5 bits (88), Expect = 0.004
Identities = 38/132 (28%), Positives = 61/132 (46%), Gaps = 14/132 (10%)
Query: 32 RLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQC 91
RL K LL+ R+DE +A+A E Q Q LQ A G E + A++ +
Sbjct: 853 RLFTKVKPLLQ---VTRQDEVLQARAQELQKVQELQQQSAREVG---ELQGRVAQLEEER 906
Query: 92 HALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQ-------L 144
L E ++ + +L E + RG+L A ++E E E +GE ++ Q L
Sbjct: 907 ARLAEQLRAEA-ELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRL 965
Query: 145 RAHMADMEAKYE 156
+ H+ ++EA E
Sbjct: 966 QQHIQELEAHLE 977
Score = 36.6 bits (83), Expect = 0.016
Identities = 52/200 (26%), Positives = 91/200 (45%), Gaps = 21/200 (10%)
Query: 4 KNKEKGKKSGAQKKKKNWGADVVAESRHRLVVLEK--ELLRDHLALRRDEARRAKA-SED 60
+ +EKG++ + K++ G +E + ++V ++ E LR L + +E + A A +ED
Sbjct: 1061 RKEEKGRQELEKLKRRLDGES--SELQEQMVEQQQRAEELRAQLGRKEEELQAALARAED 1118
Query: 61 QLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQ---LEEEVKGLRGQLE 117
+ G A+L + E +A AE + + KQ L EE++ LRG+LE
Sbjct: 1119 E-----GGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELE 1173
Query: 118 ACQREAAAARE---EAEQALGERDQAL-AQLRAHMA---DMEAKYEEILHDSLDRLLAKL 170
A +E + EQ + E + L + R H A ++ ++ + L + L L +
Sbjct: 1174 DTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE-LAEQLEQA 1232
Query: 171 RAIKQQWDGAALRLHARHKE 190
R K W+ L L A E
Sbjct: 1233 RRGKGAWEKTRLALEAEVSE 1252
Score = 32.7 bits (73), Expect = 0.23
Identities = 31/121 (25%), Positives = 51/121 (42%), Gaps = 22/121 (18%)
Query: 27 AESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAE 86
AE R + VVL+ E R RD+ + QL+++L+ E E A++ + + E
Sbjct: 1864 AEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRE 1923
Query: 87 MSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQ--------------REAAAAREEAEQ 132
+ ED+ ++ + EV LR +L E A+ EEAE+
Sbjct: 1924 L--------EDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEE 1975
Query: 133 A 133
A
Sbjct: 1976 A 1976
Score = 32.0 bits (71), Expect = 0.39
Identities = 34/147 (23%), Positives = 61/147 (41%), Gaps = 9/147 (6%)
Query: 52 ARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKG 111
++ K ED+L + E E +S K + + A DM+ R L +E KG
Sbjct: 1015 SKERKLLEDRLAEFSSQAAEEEEKVKSLNK-----LRLKYEATIADMEDR---LRKEEKG 1066
Query: 112 LRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLR 171
R +LE +R E ++ + E+ Q +LRA + E + + L + D A+ +
Sbjct: 1067 -RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQ 1125
Query: 172 AIKQQWDGAALRLHARHKEQQRQFGLT 198
+K + A A+ + + T
Sbjct: 1126 LLKSLREAQAALAEAQEDLESERVART 1152
Score = 32.0 bits (71), Expect = 0.39
Identities = 28/120 (23%), Positives = 55/120 (45%), Gaps = 10/120 (8%)
Query: 41 LRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQT 100
L D L D R + + L+ + E +L+G G+ ++++Q + +
Sbjct: 1568 LEDELTAAEDAKLRLEVTVQALKTQH---ERDLQGRDEAGEERRRQLAKQLRDAEVERDE 1624
Query: 101 RSKQLEEEV---KGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYEE 157
KQ V K L G+LE + + A+A + E+A+ + L +++A M ++ + EE
Sbjct: 1625 ERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAV----KQLRKMQAQMKELWREVEE 1680
Score = 29.6 bits (65), Expect = 1.9
Identities = 50/220 (22%), Positives = 89/220 (40%), Gaps = 47/220 (21%)
Query: 16 KKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEAR-----RAKASEDQLRQRLQ--- 67
+KK+ ++AE + ++ +E R R EAR RA E + R+ L+
Sbjct: 1464 EKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQN 1523
Query: 68 -GVEAELEGARSE----GKAIYAEMSRQCHALQE---DMQTRSKQLEEEV---------- 109
+ AELE S GK+++ E+ R C ++ D++ + +LE+E+
Sbjct: 1524 RALRAELEALLSSKDDVGKSVH-ELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRL 1582
Query: 110 ------------KGLRGQLEACQ---REAAAAREEAEQALGERDQALAQLRAHMADMEAK 154
+ L+G+ EA + R+ A +AE E + A +E +
Sbjct: 1583 EVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGE 1642
Query: 155 YEEILHDSLDRLLAKLRAIKQQWDGAALRLHARHKEQQRQ 194
EE+ K A+KQ ++ A+ KE R+
Sbjct: 1643 LEELKAQMASAGQGKEEAVKQ-----LRKMQAQMKELWRE 1677
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 45.1 bits (105), Expect = 4e-05
Identities = 40/135 (29%), Positives = 67/135 (49%), Gaps = 8/135 (5%)
Query: 47 LRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLE 106
LR++E R + ++L++RL G +EL+ E + E+ Q +E++Q + E
Sbjct: 1101 LRKEEKGRQEL--EKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE 1158
Query: 107 EEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEI---LHDSL 163
+E G R QL REA AA EA++ L A + D+ + E + L D+L
Sbjct: 1159 DE-GGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTL 1217
Query: 164 DRLLA--KLRAIKQQ 176
D A +LR+ ++Q
Sbjct: 1218 DSTNAQQELRSKREQ 1232
Score = 43.9 bits (102), Expect = 1e-04
Identities = 44/189 (23%), Positives = 79/189 (41%), Gaps = 38/189 (20%)
Query: 39 ELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDM 98
EL + R + RA+A + QR Q + GA +E ++ +S++ + + +
Sbjct: 1316 ELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQL 1375
Query: 99 QTRSKQLEEEVKG---LRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADME--- 152
+ L+EE + L ++ A + EAA RE+ E+ R++A +L+ A +
Sbjct: 1376 HDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWR 1435
Query: 153 --------------------AKYEEIL-------HDSLDRLLAKLRAIKQQWDGAALRLH 185
A+ E L +++DRL R ++Q+ D A + L
Sbjct: 1436 RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDL- 1494
Query: 186 ARHKEQQRQ 194
EQQRQ
Sbjct: 1495 ----EQQRQ 1499
Score = 41.2 bits (95), Expect = 6e-04
Identities = 55/203 (27%), Positives = 84/203 (41%), Gaps = 34/203 (16%)
Query: 26 VAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLR-----QRLQGVEAELEGARSEG 80
V E + R+ LE+E R LR + A+A E + R Q L+ V +ELE E
Sbjct: 933 VGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEE 992
Query: 81 KAIYAEMSRQCHALQEDMQTRSKQLE-EEVKGLRGQLEACQREAAAAREEAEQALGE--- 136
+ +M + LQ+ +Q LE EE + QLE EA + E + L E
Sbjct: 993 EECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQN 1052
Query: 137 ---------RDQALAQLRAHMADME----------AKYEEILHDSLDRL------LAKLR 171
+ LA+ + A+ E KYE + D DRL +L
Sbjct: 1053 SKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELE 1112
Query: 172 AIKQQWDGAALRLHARHKEQQRQ 194
+K++ DG + L + EQQ++
Sbjct: 1113 KLKRRLDGESSELQEQMVEQQQR 1135
Score = 40.8 bits (94), Expect = 8e-04
Identities = 46/195 (23%), Positives = 83/195 (42%), Gaps = 37/195 (18%)
Query: 15 QKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELE 74
Q ++ G D E R R + + LRD + RDE R+ + R++L+G EL+
Sbjct: 1633 QHERDLQGRDEAGEERRRQLAKQ---LRD-AEVERDEERKQRTLAVAARKKLEGELEELK 1688
Query: 75 GARSEGKAIYAEMSRQCHALQEDMQ-----------------TRSKQLEEEVKGLRGQLE 117
+ E +Q +Q M+ +++++ E+ +KGL ++
Sbjct: 1689 AQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVL 1748
Query: 118 ACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQW 177
Q E AA+ QA +RD+ MAD E+ + +L + A + K+Q
Sbjct: 1749 RLQEELAASDRARRQAQQDRDE--------MAD------EVANGNLSK--AAILEEKRQL 1792
Query: 178 DGAALRLHARHKEQQ 192
+G +L +E+Q
Sbjct: 1793 EGRLGQLEEELEEEQ 1807
Score = 40.4 bits (93), Expect = 0.001
Identities = 48/218 (22%), Positives = 86/218 (39%), Gaps = 40/218 (18%)
Query: 15 QKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAEL- 73
+++++ GA E R E E L LA + + R + +L+Q L +L
Sbjct: 1436 RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLE 1495
Query: 74 ----------------------------------EGARSEGKAIYAEMSRQCHALQEDMQ 99
E A +EG+ A AL+E+ +
Sbjct: 1496 QQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQE 1555
Query: 100 TRSKQLEEEVKGLRGQLEA---CQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYE 156
R ++LE + + LR +LEA + + + E E+A +QA LRA + ++E +
Sbjct: 1556 AR-EELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDEL- 1613
Query: 157 EILHDSLDRLLAKLRAIKQQWDGAALRLHARHKEQQRQ 194
D+ RL ++A+K Q + +E++RQ
Sbjct: 1614 TAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQ 1651
Score = 38.9 bits (89), Expect = 0.003
Identities = 42/138 (30%), Positives = 64/138 (46%), Gaps = 25/138 (18%)
Query: 45 LALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQ 104
LA + ++ARR K + ++ R L+ +EL AE+S A QE Q R ++
Sbjct: 1266 LAEQLEQARRGKGAWEKTRLALEAEVSELR----------AELSSLQTARQEGEQRR-RR 1314
Query: 105 LE---EEVKGLRGQLEACQREAA-------AAREEAEQALGERDQALAQLRAHMADMEAK 154
LE +EV+G G E + EAA A E AL E + +L ++ EA+
Sbjct: 1315 LELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ 1374
Query: 155 YEEILHDSLDRLLAKLRA 172
LHD+ + L + RA
Sbjct: 1375 ----LHDAQELLQEETRA 1388
Score = 38.5 bits (88), Expect = 0.004
Identities = 38/132 (28%), Positives = 61/132 (46%), Gaps = 14/132 (10%)
Query: 32 RLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQC 91
RL K LL+ R+DE +A+A E Q Q LQ A G E + A++ +
Sbjct: 894 RLFTKVKPLLQ---VTRQDEVLQARAQELQKVQELQQQSAREVG---ELQGRVAQLEEER 947
Query: 92 HALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQ-------L 144
L E ++ + +L E + RG+L A ++E E E +GE ++ Q L
Sbjct: 948 ARLAEQLRAEA-ELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRL 1006
Query: 145 RAHMADMEAKYE 156
+ H+ ++EA E
Sbjct: 1007 QQHIQELEAHLE 1018
Score = 36.6 bits (83), Expect = 0.016
Identities = 52/200 (26%), Positives = 91/200 (45%), Gaps = 21/200 (10%)
Query: 4 KNKEKGKKSGAQKKKKNWGADVVAESRHRLVVLEK--ELLRDHLALRRDEARRAKA-SED 60
+ +EKG++ + K++ G +E + ++V ++ E LR L + +E + A A +ED
Sbjct: 1102 RKEEKGRQELEKLKRRLDGES--SELQEQMVEQQQRAEELRAQLGRKEEELQAALARAED 1159
Query: 61 QLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQ---LEEEVKGLRGQLE 117
+ G A+L + E +A AE + + KQ L EE++ LRG+LE
Sbjct: 1160 E-----GGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELE 1214
Query: 118 ACQREAAAARE---EAEQALGERDQAL-AQLRAHMA---DMEAKYEEILHDSLDRLLAKL 170
A +E + EQ + E + L + R H A ++ ++ + L + L L +
Sbjct: 1215 DTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE-LAEQLEQA 1273
Query: 171 RAIKQQWDGAALRLHARHKE 190
R K W+ L L A E
Sbjct: 1274 RRGKGAWEKTRLALEAEVSE 1293
Score = 32.7 bits (73), Expect = 0.23
Identities = 31/121 (25%), Positives = 51/121 (42%), Gaps = 22/121 (18%)
Query: 27 AESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAE 86
AE R + VVL+ E R RD+ + QL+++L+ E E A++ + + E
Sbjct: 1905 AEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRE 1964
Query: 87 MSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQ--------------REAAAAREEAEQ 132
+ ED+ ++ + EV LR +L E A+ EEAE+
Sbjct: 1965 L--------EDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEE 2016
Query: 133 A 133
A
Sbjct: 2017 A 2017
Score = 32.0 bits (71), Expect = 0.39
Identities = 34/147 (23%), Positives = 61/147 (41%), Gaps = 9/147 (6%)
Query: 52 ARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKG 111
++ K ED+L + E E +S K + + A DM+ R L +E KG
Sbjct: 1056 SKERKLLEDRLAEFSSQAAEEEEKVKSLNK-----LRLKYEATIADMEDR---LRKEEKG 1107
Query: 112 LRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLR 171
R +LE +R E ++ + E+ Q +LRA + E + + L + D A+ +
Sbjct: 1108 -RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQ 1166
Query: 172 AIKQQWDGAALRLHARHKEQQRQFGLT 198
+K + A A+ + + T
Sbjct: 1167 LLKSLREAQAALAEAQEDLESERVART 1193
Score = 32.0 bits (71), Expect = 0.39
Identities = 28/120 (23%), Positives = 55/120 (45%), Gaps = 10/120 (8%)
Query: 41 LRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQT 100
L D L D R + + L+ + E +L+G G+ ++++Q + +
Sbjct: 1609 LEDELTAAEDAKLRLEVTVQALKTQH---ERDLQGRDEAGEERRRQLAKQLRDAEVERDE 1665
Query: 101 RSKQLEEEV---KGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYEE 157
KQ V K L G+LE + + A+A + E+A+ + L +++A M ++ + EE
Sbjct: 1666 ERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAV----KQLRKMQAQMKELWREVEE 1721
Score = 29.6 bits (65), Expect = 1.9
Identities = 50/220 (22%), Positives = 89/220 (40%), Gaps = 47/220 (21%)
Query: 16 KKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEAR-----RAKASEDQLRQRLQ--- 67
+KK+ ++AE + ++ +E R R EAR RA E + R+ L+
Sbjct: 1505 EKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQN 1564
Query: 68 -GVEAELEGARSE----GKAIYAEMSRQCHALQE---DMQTRSKQLEEEV---------- 109
+ AELE S GK+++ E+ R C ++ D++ + +LE+E+
Sbjct: 1565 RALRAELEALLSSKDDVGKSVH-ELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRL 1623
Query: 110 ------------KGLRGQLEACQ---REAAAAREEAEQALGERDQALAQLRAHMADMEAK 154
+ L+G+ EA + R+ A +AE E + A +E +
Sbjct: 1624 EVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGE 1683
Query: 155 YEEILHDSLDRLLAKLRAIKQQWDGAALRLHARHKEQQRQ 194
EE+ K A+KQ ++ A+ KE R+
Sbjct: 1684 LEELKAQMASAGQGKEEAVKQ-----LRKMQAQMKELWRE 1718
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.127 0.352
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,052,688
Number of Sequences: 37866
Number of extensions: 340764
Number of successful extensions: 4755
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 299
Number of HSP's successfully gapped in prelim test: 585
Number of HSP's that attempted gapping in prelim test: 2379
Number of HSP's gapped (non-prelim): 2264
length of query: 210
length of database: 18,247,518
effective HSP length: 98
effective length of query: 112
effective length of database: 14,536,650
effective search space: 1628104800
effective search space used: 1628104800
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.