Search of human proteins with 222418558

Search of human proteins with 222418558

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|222418558 methylenetetrahydrofolate dehydrogenase 2-like
[Homo sapiens]
         (347 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|222418558 methylenetetrahydrofolate dehydrogenase 2-like [Hom...   686   0.0  
gi|94721354 methylenetetrahydrofolate dehydrogenase 2 precursor ...   467   e-132
gi|222136639 methylenetetrahydrofolate dehydrogenase 1 [Homo sap...   190   2e-48
gi|36796743 methylenetetrahydrofolate dehydrogenase (NADP+ depen...    80   2e-15
gi|209976994 adenylate cyclase 10 [Homo sapiens]                       30   2.4  
gi|21735621 mitochondrial malate dehydrogenase precursor [Homo s...    30   2.4  
gi|121674801 hepatocyte cell adhesion molecule [Homo sapiens]          30   3.2  
gi|21359974 vitrin [Homo sapiens]                                      30   4.2  
gi|156415990 Y box binding protein 2 [Homo sapiens]                    29   5.4  
gi|226061853 TatD DNase domain containing 3 isoform 5 [Homo sapi...    29   7.1  
gi|21359873 polo-like kinase 1 [Homo sapiens]                          28   9.3  
gi|15147346 fibroblast growth factor 8 isoform F precursor [Homo...    28   9.3  
gi|214831601 general transcription factor IIH, polypeptide 1, 62...    28   9.3  
gi|4885365 general transcription factor IIH, polypeptide 1, 62kD...    28   9.3  
gi|116268127 kinase non-catalytic C-lobe domain (KIND) containin...    28   9.3  

>gi|222418558 methylenetetrahydrofolate dehydrogenase 2-like [Homo
           sapiens]
          Length = 347

 Score =  686 bits (1771), Expect = 0.0
 Identities = 347/347 (100%), Positives = 347/347 (100%)

Query: 1   MTVPVRGFSLLRGRLGRAPALGRSTAPSVRAPGEPGSAFRGFRSSGVRHEAIIISGTEMA 60
           MTVPVRGFSLLRGRLGRAPALGRSTAPSVRAPGEPGSAFRGFRSSGVRHEAIIISGTEMA
Sbjct: 1   MTVPVRGFSLLRGRLGRAPALGRSTAPSVRAPGEPGSAFRGFRSSGVRHEAIIISGTEMA 60

Query: 61  KHIQKEIQRGVESWVSLGNRRPHLSIILVGDNPASHTYVRNKIRAASAVGICSELILKPK 120
           KHIQKEIQRGVESWVSLGNRRPHLSIILVGDNPASHTYVRNKIRAASAVGICSELILKPK
Sbjct: 61  KHIQKEIQRGVESWVSLGNRRPHLSIILVGDNPASHTYVRNKIRAASAVGICSELILKPK 120

Query: 121 DVSQEELLDVTDQLNMDPRVSGILVQLPLPDHVDERTICNGIAPEKDVDGFHIINIGRLC 180
           DVSQEELLDVTDQLNMDPRVSGILVQLPLPDHVDERTICNGIAPEKDVDGFHIINIGRLC
Sbjct: 121 DVSQEELLDVTDQLNMDPRVSGILVQLPLPDHVDERTICNGIAPEKDVDGFHIINIGRLC 180

Query: 181 LDQHSLIPATASAVWEIIKRTGIQTFGKNVVVAGRSKNVGMPIAMLLHTDGEHERPGGDA 240
           LDQHSLIPATASAVWEIIKRTGIQTFGKNVVVAGRSKNVGMPIAMLLHTDGEHERPGGDA
Sbjct: 181 LDQHSLIPATASAVWEIIKRTGIQTFGKNVVVAGRSKNVGMPIAMLLHTDGEHERPGGDA 240

Query: 241 TVTIAHRYTPKEQLKIHTQLADIIIVAAGIPKLITSDMVKEGAAVIDVGINYVHDPVTGK 300
           TVTIAHRYTPKEQLKIHTQLADIIIVAAGIPKLITSDMVKEGAAVIDVGINYVHDPVTGK
Sbjct: 241 TVTIAHRYTPKEQLKIHTQLADIIIVAAGIPKLITSDMVKEGAAVIDVGINYVHDPVTGK 300

Query: 301 TKLVGDVDFEAVKKKAGFITPVPGGVGPMTVAMLLKNTLLAAKKIIY 347
           TKLVGDVDFEAVKKKAGFITPVPGGVGPMTVAMLLKNTLLAAKKIIY
Sbjct: 301 TKLVGDVDFEAVKKKAGFITPVPGGVGPMTVAMLLKNTLLAAKKIIY 347


>gi|94721354 methylenetetrahydrofolate dehydrogenase 2 precursor
           [Homo sapiens]
          Length = 350

 Score =  467 bits (1202), Expect = e-132
 Identities = 221/307 (71%), Positives = 270/307 (87%)

Query: 40  RGFRSSGVRHEAIIISGTEMAKHIQKEIQRGVESWVSLGNRRPHLSIILVGDNPASHTYV 99
           R F  + VR+EA++ISG ++A+ I++E+++ VE WV+ GN+RPHLS+ILVG+NPASH+YV
Sbjct: 26  RPFHLAAVRNEAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYV 85

Query: 100 RNKIRAASAVGICSELILKPKDVSQEELLDVTDQLNMDPRVSGILVQLPLPDHVDERTIC 159
            NK RAA+ VGI SE I+KP  +S+EELL++ ++LN D  V G+LVQLPLP+H+DER IC
Sbjct: 86  LNKTRAAAVVGINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRIC 145

Query: 160 NGIAPEKDVDGFHIINIGRLCLDQHSLIPATASAVWEIIKRTGIQTFGKNVVVAGRSKNV 219
           N ++P+KDVDGFH+IN+GR+CLDQ+S++PAT   VWEIIKRTGI T GKNVVVAGRSKNV
Sbjct: 146 NAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNV 205

Query: 220 GMPIAMLLHTDGEHERPGGDATVTIAHRYTPKEQLKIHTQLADIIIVAAGIPKLITSDMV 279
           GMPIAMLLHTDG HERPGGDATVTI+HRYTPKEQLK HT LADI+I AAGIP LIT+DM+
Sbjct: 206 GMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMI 265

Query: 280 KEGAAVIDVGINYVHDPVTGKTKLVGDVDFEAVKKKAGFITPVPGGVGPMTVAMLLKNTL 339
           KEGAAVIDVGIN VHDPVT K KLVGDVDFE V++KAG+ITPVPGGVGPMTVAML+KNT+
Sbjct: 266 KEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTI 325

Query: 340 LAAKKII 346
           +AAKK++
Sbjct: 326 IAAKKVL 332


>gi|222136639 methylenetetrahydrofolate dehydrogenase 1 [Homo
           sapiens]
          Length = 935

 Score =  190 bits (482), Expect = 2e-48
 Identities = 118/302 (39%), Positives = 171/302 (56%), Gaps = 16/302 (5%)

Query: 51  AIIISGTEMAKHIQKEIQRGVESWVS-LGNRRPHLSIILVGDNPASHTYVRNKIRAASAV 109
           A I++G E++  I+  ++  V      +    P L+I+ VG+   S+ Y+  K++AA  +
Sbjct: 4   AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63

Query: 110 GICSELILKPKDVSQEELLDVTDQLNMDPRVSGILVQLPLPDH--VDERTICNGIAPEKD 167
           GI +  I  P+  ++ E++     LN D  V G LVQLPL     ++   + N IAPEKD
Sbjct: 64  GIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKD 123

Query: 168 VDGFHIINIGRLCLDQHS--LIPATASAVWEIIKRTGIQTFGKNVVVAGRSKNVGMPIAM 225
           VDG   IN G+L     +   IP T     E+IK TG+   G++ VV GRSK VG P+  
Sbjct: 124 VDGLTSINAGKLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPMHD 183

Query: 226 LLHTDGEHERPGGDATVTIAHRYTPKEQLKIHTQLADIIIVAAGIPKLITSDMVKEGAAV 285
           LL  +        +ATVT  H  T    L       DI++VA G P+++  + +K GA V
Sbjct: 184 LLLWN--------NATVTTCHSKTA--HLDEEVNKGDILVVATGQPEMVKGEWIKPGAIV 233

Query: 286 IDVGINYV-HDPVTGKTKLVGDVDFEAVKKKAGFITPVPGGVGPMTVAMLLKNTLLAAKK 344
           ID GINYV  D      K+VGDV ++  K++A FITPVPGGVGPMTVAML+++T+ +AK+
Sbjct: 234 IDCGINYVPDDKKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKR 293

Query: 345 II 346
            +
Sbjct: 294 FL 295


>gi|36796743 methylenetetrahydrofolate dehydrogenase (NADP+
           dependent) 1-like [Homo sapiens]
          Length = 978

 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 64/222 (28%), Positives = 111/222 (50%), Gaps = 21/222 (9%)

Query: 81  RPHLSIILVGDNPASHTYVRNKIRAASAVGICSELILKPKDVSQEELLDVTDQLNMDPRV 140
           +P L+II  GD+       +N    A   G+    I  P D S+ E++D   ++N D RV
Sbjct: 97  KPVLAIIQAGDDNLMQEINQN---LAEEAGLNITHICLPPDSSEAEIIDEILKINEDTRV 153

Query: 141 SGILVQLPLPDHVDERTICNGIAPEKDVDGFHIINIGRLCL-DQHS-LIPATASAVWEII 198
            G+ +Q+   +++    + N + PEKDVDG   IN+G+L   D H   +   A AV E++
Sbjct: 154 HGLALQIS--ENLFSNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELL 211

Query: 199 KRTGIQTFGKNVVVAGRSKNVGMPIAMLLHTDGEHERPGGDATVTIAHRYTPKEQLKIHT 258
           +++G+   GK ++V G   ++   +  L           G  T++I  + T + Q K+H 
Sbjct: 212 EKSGVNLDGKKILVVGAHGSLEAALQCLFQRK-------GSMTMSIQWK-TRQLQSKLHE 263

Query: 259 QLADIIIVAAGIPKLITSDMVKEGAAVIDVGINYVHDPVTGK 300
             ADI+++ +  P+ I    ++ G  V    +N  HD ++GK
Sbjct: 264 --ADIVVLGSPKPEEIPLTWIQPGTTV----LNCSHDFLSGK 299


>gi|209976994 adenylate cyclase 10 [Homo sapiens]
          Length = 1610

 Score = 30.4 bits (67), Expect = 2.4
 Identities = 22/78 (28%), Positives = 38/78 (48%), Gaps = 9/78 (11%)

Query: 65  KEIQRGVESWVSLGNRRPHLSIILVGDNPASHTYVRNK----IRAASAVGICSELILKPK 120
           +E + G++  V +G    H+S+++ GD   SH  V  +    +R A  +   +++IL P 
Sbjct: 133 QEWEEGLDIRVKIGLAAGHISMLVFGDETHSHFLVIGQAVDDVRLAQNMAQMNDVILSPN 192

Query: 121 -----DVSQEELLDVTDQ 133
                D S  E+  V DQ
Sbjct: 193 CWQLCDRSMIEIESVPDQ 210


>gi|21735621 mitochondrial malate dehydrogenase precursor [Homo
           sapiens]
          Length = 338

 Score = 30.4 bits (67), Expect = 2.4
 Identities = 29/120 (24%), Positives = 45/120 (37%), Gaps = 19/120 (15%)

Query: 185 SLIPATASAVWEIIKRTGIQTFGKNVVVAGRSKNVGMPIAMLL---------------HT 229
           S +   ASA       T  Q   K V V G S  +G P+++LL               HT
Sbjct: 3   SALARPASAALRRSFSTSAQNNAK-VAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHT 61

Query: 230 DGEHERPGGDATVTIAHRYTPKEQLKIHTQLADIIIVAAGIPK---LITSDMVKEGAAVI 286
            G         T      Y   EQL    +  D++++ AG+P+   +   D+    A ++
Sbjct: 62  PGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIV 121


>gi|121674801 hepatocyte cell adhesion molecule [Homo sapiens]
          Length = 416

 Score = 30.0 bits (66), Expect = 3.2
 Identities = 18/48 (37%), Positives = 25/48 (52%), Gaps = 3/48 (6%)

Query: 3   VPVRGFSLLRGRLGRAPALGRSTAPSVRAPGEPG---SAFRGFRSSGV 47
           +P+R          R+PA GR+ +   RAP  PG   SA R  R++GV
Sbjct: 353 LPIRSARRYPRSPARSPATGRTHSSPPRAPSSPGRSRSASRTLRTAGV 400


>gi|21359974 vitrin [Homo sapiens]
          Length = 693

 Score = 29.6 bits (65), Expect = 4.2
 Identities = 12/34 (35%), Positives = 20/34 (58%)

Query: 63  IQKEIQRGVESWVSLGNRRPHLSIILVGDNPASH 96
           IQK++   V   + +G   P + ++  GDNPA+H
Sbjct: 326 IQKQLLADVAQALDIGPAGPLMGVVQYGDNPATH 359


>gi|156415990 Y box binding protein 2 [Homo sapiens]
          Length = 364

 Score = 29.3 bits (64), Expect = 5.4
 Identities = 14/39 (35%), Positives = 18/39 (46%)

Query: 13 GRLGRAPALGRSTAPSVRAPGEPGSAFRGFRSSGVRHEA 51
          G     PA G  +AP  R PG P +A  G  +   R +A
Sbjct: 47 GGAASGPAAGTPSAPGSRTPGNPATAVSGTPAPPARSQA 85


>gi|226061853 TatD DNase domain containing 3 isoform 5 [Homo
           sapiens]
          Length = 281

 Score = 28.9 bits (63), Expect = 7.1
 Identities = 34/118 (28%), Positives = 54/118 (45%), Gaps = 18/118 (15%)

Query: 33  GEPGSAFRGFRSSGVRH--EAIIISGTEMAKHIQKEIQRGVESWVSLGNRRPHLSIILVG 90
           G P  A  G R+        +II SG  ++   +K+          L  + P  SI L  
Sbjct: 174 GRPSVAMEGVRAGYFFSIPPSIIRSGQLLSLFSKKQ---------KLVKQLPLTSICLET 224

Query: 91  DNPA--SHTYVRNKIRAASAVGICSELILKPKDVSQEELLDVTDQ--LNMDPRVSGIL 144
           D+PA      VRN+      + I +E I + K +S EE+++VT Q  L + P++  +L
Sbjct: 225 DSPALGPEKQVRNE---PWNISISAEYIAQVKGISVEEVIEVTTQNALKLFPKLRHLL 279


>gi|21359873 polo-like kinase 1 [Homo sapiens]
          Length = 603

 Score = 28.5 bits (62), Expect = 9.3
 Identities = 14/27 (51%), Positives = 18/27 (66%), Gaps = 1/27 (3%)

Query: 13 GRLGRAPA-LGRSTAPSVRAPGEPGSA 38
          G+L RAPA  G++  P V APG P +A
Sbjct: 8  GKLARAPADPGKAGVPGVAAPGAPAAA 34


>gi|15147346 fibroblast growth factor 8 isoform F precursor [Homo
          sapiens]
          Length = 244

 Score = 28.5 bits (62), Expect = 9.3
 Identities = 16/51 (31%), Positives = 23/51 (45%), Gaps = 9/51 (17%)

Query: 16 GRAPALGRSTAPSVRAPGEPGSAFRGFRSSGVRHEAIIISGTEMAKHIQKE 66
          GR PALGR  A   RA  EP          GV  +  + S     +H++++
Sbjct: 27 GRGPALGRELASLFRAGREP---------QGVSQQVTVQSSPNFTQHVREQ 68


>gi|214831601 general transcription factor IIH, polypeptide 1, 62kDa
           [Homo sapiens]
          Length = 548

 Score = 28.5 bits (62), Expect = 9.3
 Identities = 16/68 (23%), Positives = 32/68 (47%)

Query: 40  RGFRSSGVRHEAIIISGTEMAKHIQKEIQRGVESWVSLGNRRPHLSIILVGDNPASHTYV 99
           R F+S     + +     ++     K  ++G+++ VSLG + P L +  + D P    Y 
Sbjct: 223 RFFQSHYFHRDRLNTGSKDLFAECAKIDEKGLKTMVSLGVKNPLLDLTALEDKPLDEGYG 282

Query: 100 RNKIRAAS 107
            + + +AS
Sbjct: 283 ISSVPSAS 290


>gi|4885365 general transcription factor IIH, polypeptide 1, 62kDa
           [Homo sapiens]
          Length = 548

 Score = 28.5 bits (62), Expect = 9.3
 Identities = 16/68 (23%), Positives = 32/68 (47%)

Query: 40  RGFRSSGVRHEAIIISGTEMAKHIQKEIQRGVESWVSLGNRRPHLSIILVGDNPASHTYV 99
           R F+S     + +     ++     K  ++G+++ VSLG + P L +  + D P    Y 
Sbjct: 223 RFFQSHYFHRDRLNTGSKDLFAECAKIDEKGLKTMVSLGVKNPLLDLTALEDKPLDEGYG 282

Query: 100 RNKIRAAS 107
            + + +AS
Sbjct: 283 ISSVPSAS 290


>gi|116268127 kinase non-catalytic C-lobe domain (KIND) containing 1
           isoform a [Homo sapiens]
          Length = 1749

 Score = 28.5 bits (62), Expect = 9.3
 Identities = 14/33 (42%), Positives = 15/33 (45%)

Query: 14  RLGRAPALGRSTAPSVRAPGEPGSAFRGFRSSG 46
           +LGR P  GRST      PG PG       S G
Sbjct: 372 QLGRVPCAGRSTDRGPGVPGSPGQPETSHPSQG 404


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.137    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,508,952
Number of Sequences: 37866
Number of extensions: 617482
Number of successful extensions: 1524
Number of sequences better than 10.0: 15
Number of HSP's better than 10.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 1511
Number of HSP's gapped (non-prelim): 15
length of query: 347
length of database: 18,247,518
effective HSP length: 103
effective length of query: 244
effective length of database: 14,347,320
effective search space: 3500746080
effective search space used: 3500746080
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.