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Search of human proteins with 222144233
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222144233 fibroblast growth factor receptor 2 isoform 4
precursor [Homo sapiens]
(709 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 1453 0.0
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 1305 0.0
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 1025 0.0
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 1016 0.0
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 959 0.0
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 958 0.0
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 901 0.0
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 895 0.0
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 842 0.0
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 825 0.0
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 788 0.0
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 788 0.0
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 782 0.0
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 782 0.0
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 690 0.0
gi|13186249 fibroblast growth factor receptor 1 isoform 9 precur... 683 0.0
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 681 0.0
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 569 e-162
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 569 e-162
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 544 e-154
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 329 5e-90
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 329 5e-90
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [... 322 6e-88
gi|11321597 kinase insert domain receptor precursor [Homo sapiens] 318 8e-87
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge... 289 7e-78
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene... 289 7e-78
gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like... 244 2e-64
gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap... 244 2e-64
gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [... 230 3e-60
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 228 2e-59
>gi|222144233 fibroblast growth factor receptor 2 isoform 4
precursor [Homo sapiens]
Length = 709
Score = 1453 bits (3762), Expect = 0.0
Identities = 709/709 (100%), Positives = 709/709 (100%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
Query: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
Sbjct: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
Sbjct: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
Query: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
Sbjct: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
Query: 241 NHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQ 300
NHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQ
Sbjct: 241 NHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQ 300
Query: 301 PAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDP 360
PAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDP
Sbjct: 301 PAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDP 360
Query: 361 KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLV 420
KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLV
Sbjct: 361 KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLV 420
Query: 421 SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINR 480
SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINR
Sbjct: 421 SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINR 480
Query: 481 VPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDIN 540
VPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDIN
Sbjct: 481 VPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDIN 540
Query: 541 NIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEEL 600
NIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEEL
Sbjct: 541 NIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEEL 600
Query: 601 FKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDL 660
FKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDL
Sbjct: 601 FKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDL 660
Query: 661 SQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT 709
SQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
Sbjct: 661 SQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT 709
>gi|222144239 fibroblast growth factor receptor 2 isoform 7
precursor [Homo sapiens]
Length = 705
Score = 1305 bits (3377), Expect = 0.0
Identities = 649/714 (90%), Positives = 658/714 (92%), Gaps = 14/714 (1%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
Query: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
Sbjct: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
Sbjct: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
Query: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
Sbjct: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
Query: 241 NHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQ 300
NHTYHLDVV + I + + G C V + +P
Sbjct: 241 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYS---------DAQPHIQWI 291
Query: 301 PAVHKLTKR-----IPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYE 355
V K + +P + + VSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYE
Sbjct: 292 KHVEKNGSKYGPDGLPYLKVLKVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYE 351
Query: 356 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 415
LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD
Sbjct: 352 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 411
Query: 416 LSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS 475
LSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS
Sbjct: 412 LSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS 471
Query: 476 YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGL 535
YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGL
Sbjct: 472 YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGL 531
Query: 536 ARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI 595
ARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI
Sbjct: 532 ARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI 591
Query: 596 PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 655
PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE
Sbjct: 592 PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 651
Query: 656 EYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT 709
EYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
Sbjct: 652 EYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT 705
>gi|222144237 fibroblast growth factor receptor 2 isoform 6
precursor [Homo sapiens]
Length = 706
Score = 1025 bits (2649), Expect = 0.0
Identities = 537/734 (73%), Positives = 575/734 (78%), Gaps = 53/734 (7%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--TKYQISQPEVYVAAPGESL 58
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE P T + + ++ ++
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
Query: 59 EVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGEY--------LQIKGATPRDSGLYACT 108
+ RC + W K+G +R IG Y L ++ P D G Y C
Sbjct: 61 KFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGGYKVRNQHWSLIMESVVPSDKGNYTCV 117
Query: 109 ASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHA 168
S + ++V + R+P+ + +
Sbjct: 118 VENEYGSINHTYHLDVVE-------------------------RSPHRPILQAGLPANAS 152
Query: 169 VPAANTVKFRCPAGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLI 217
V+F C + P ++W+K NG ++ + + G ++ ++
Sbjct: 153 TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVL 212
Query: 218 -MESVVPSDKGNYTCVVENEYGSINHTYHLDVV-APGREKEITASPDYLEIAIYCIGVFL 275
+ +V D G YTC+ N G H+ L V+ APGREKEITASPDYLEIAIYCIGVFL
Sbjct: 213 YIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFL 272
Query: 276 IACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRI 335
IACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRI
Sbjct: 273 IACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRI 332
Query: 336 TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 395
TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK
Sbjct: 333 TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 392
Query: 396 PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA 455
PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA
Sbjct: 393 PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA 452
Query: 456 SKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDL 515
SKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDL
Sbjct: 453 SKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDL 512
Query: 516 AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 575
AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW
Sbjct: 513 AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 572
Query: 576 SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR 635
SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR
Sbjct: 573 SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR 632
Query: 636 PTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 695
PTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP
Sbjct: 633 PTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 692
Query: 696 CLPQYPHINGSVKT 709
CLPQYPHINGSVKT
Sbjct: 693 CLPQYPHINGSVKT 706
>gi|222144241 fibroblast growth factor receptor 2 isoform 8
precursor [Homo sapiens]
Length = 704
Score = 1016 bits (2627), Expect = 0.0
Identities = 535/734 (72%), Positives = 573/734 (78%), Gaps = 55/734 (7%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--TKYQISQPEVYVAAPGESL 58
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE P T + + ++ ++
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
Query: 59 EVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGEY--------LQIKGATPRDSGLYACT 108
+ RC + W K+G +R IG Y L ++ P D G Y C
Sbjct: 61 KFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGGYKVRNQHWSLIMESVVPSDKGNYTCV 117
Query: 109 ASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHA 168
S + ++V + R+P+ + +
Sbjct: 118 VENEYGSINHTYHLDVVE-------------------------RSPHRPILQAGLPANAS 152
Query: 169 VPAANTVKFRCPAGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLI 217
V+F C + P ++W+K NG ++ + + G ++ ++
Sbjct: 153 TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVL 212
Query: 218 -MESVVPSDKGNYTCVVENEYGSINHTYHLDVV-APGREKEITASPDYLEIAIYCIGVFL 275
+ +V D G YTC+ N G H+ L V+ APGREKEITASPDYLEIAIYCIGVFL
Sbjct: 213 YIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFL 272
Query: 276 IACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRI 335
IACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV SAESSSSMNSNTPLVRI
Sbjct: 273 IACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV--SAESSSSMNSNTPLVRI 330
Query: 336 TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 395
TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK
Sbjct: 331 TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 390
Query: 396 PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA 455
PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA
Sbjct: 391 PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA 450
Query: 456 SKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDL 515
SKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDL
Sbjct: 451 SKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDL 510
Query: 516 AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 575
AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW
Sbjct: 511 AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 570
Query: 576 SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR 635
SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR
Sbjct: 571 SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR 630
Query: 636 PTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 695
PTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP
Sbjct: 631 PTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 690
Query: 696 CLPQYPHINGSVKT 709
CLPQYPHINGSVKT
Sbjct: 691 CLPQYPHINGSVKT 704
>gi|221316639 fibroblast growth factor receptor 2 isoform 1
precursor [Homo sapiens]
Length = 821
Score = 959 bits (2479), Expect = 0.0
Identities = 480/548 (87%), Positives = 498/548 (90%), Gaps = 13/548 (2%)
Query: 175 VKFRCPAGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLI-MESVV 222
V+F C + P ++W+K NG ++ + + G ++ ++ + +V
Sbjct: 274 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVT 333
Query: 223 PSDKGNYTCVVENEYGSINHTYHLDVV-APGREKEITASPDYLEIAIYCIGVFLIACMVV 281
D G YTC+ N G H+ L V+ APGREKEITASPDYLEIAIYCIGVFLIACMVV
Sbjct: 334 FEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVV 393
Query: 282 TVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSS 341
TVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSS
Sbjct: 394 TVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSS 453
Query: 342 TADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVT 401
TADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVT
Sbjct: 454 TADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVT 513
Query: 402 VAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR 461
VAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR
Sbjct: 514 VAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR 573
Query: 462 EYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVL 521
EYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVL
Sbjct: 574 EYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVL 633
Query: 522 VTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLM 581
VTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLM
Sbjct: 634 VTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLM 693
Query: 582 WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQL 641
WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQL
Sbjct: 694 WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQL 753
Query: 642 VEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYP 701
VEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYP
Sbjct: 754 VEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYP 813
Query: 702 HINGSVKT 709
HINGSVKT
Sbjct: 814 HINGSVKT 821
Score = 518 bits (1334), Expect = e-147
Identities = 249/249 (100%), Positives = 249/249 (100%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
Query: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
Sbjct: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
Sbjct: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
Query: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
Sbjct: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
Query: 241 NHTYHLDVV 249
NHTYHLDVV
Sbjct: 241 NHTYHLDVV 249
>gi|221316638 fibroblast growth factor receptor 2 isoform 2
precursor [Homo sapiens]
Length = 822
Score = 958 bits (2477), Expect = 0.0
Identities = 482/550 (87%), Positives = 496/550 (90%), Gaps = 16/550 (2%)
Query: 175 VKFRCPAGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLIMESVVP 223
V+F C + P ++W+K NG ++ + + G N L + +V
Sbjct: 274 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAE-VLALFNVTE 332
Query: 224 SDKGNYTCVVENEYGSINHTYHLDVV----APGREKEITASPDYLEIAIYCIGVFLIACM 279
+D G Y C V N G N + L V+ APGREKEITASPDYLEIAIYCIGVFLIACM
Sbjct: 333 ADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACM 392
Query: 280 VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRL 339
VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRL
Sbjct: 393 VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRL 452
Query: 340 SSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA 399
SSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA
Sbjct: 453 SSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA 512
Query: 400 VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 459
VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN
Sbjct: 513 VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 572
Query: 460 LREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARN 519
LREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARN
Sbjct: 573 LREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARN 632
Query: 520 VLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV 579
VLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV
Sbjct: 633 VLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV 692
Query: 580 LMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFK 639
LMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFK
Sbjct: 693 LMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFK 752
Query: 640 QLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQ 699
QLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQ
Sbjct: 753 QLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQ 812
Query: 700 YPHINGSVKT 709
YPHINGSVKT
Sbjct: 813 YPHINGSVKT 822
Score = 518 bits (1334), Expect = e-147
Identities = 249/249 (100%), Positives = 249/249 (100%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
Query: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
Sbjct: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
Sbjct: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
Query: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
Sbjct: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
Query: 241 NHTYHLDVV 249
NHTYHLDVV
Sbjct: 241 NHTYHLDVV 249
>gi|222144235 fibroblast growth factor receptor 2 isoform 5
precursor [Homo sapiens]
Length = 707
Score = 901 bits (2328), Expect = 0.0
Identities = 486/729 (66%), Positives = 530/729 (72%), Gaps = 79/729 (10%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--------------------- 39
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE+
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
Query: 40 -------TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
T + + ++ +++ RC + W K+G +R IG
Sbjct: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGG 117
Query: 91 Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
Y L ++ P D G Y C S + ++V +
Sbjct: 118 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVE---------------- 161
Query: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEF 198
R+P+ + + V+F C + P ++W+K NG ++
Sbjct: 162 ---------RSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKY 212
Query: 199 KQEH-------RIGGYKVRNQHWSLI-MESVVPSDKGNYTCVVENEYGSINHTYHLDVV- 249
+ + G ++ ++ + +V D G YTC+ N G H+ L V+
Sbjct: 213 GPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLP 272
Query: 250 APGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKR 309
APGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKR
Sbjct: 273 APGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKR 332
Query: 310 IPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKL 369
IPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKL
Sbjct: 333 IPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKL 392
Query: 370 TLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMI 429
TLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMI
Sbjct: 393 TLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMI 452
Query: 430 GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFK 489
GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFK
Sbjct: 453 GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFK 512
Query: 490 DLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTT 549
DLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTT
Sbjct: 513 DLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTT 572
Query: 550 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHR 609
NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHR
Sbjct: 573 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHR 632
Query: 610 MDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSP 669
MDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEE +S ++ + P
Sbjct: 633 MDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEEKKVSGAVDCHKP 692
Query: 670 SYPDTRSSC 678
+ C
Sbjct: 693 PCNPSHLPC 701
>gi|222144244 fibroblast growth factor receptor 2 isoform 9
precursor [Homo sapiens]
Length = 680
Score = 895 bits (2314), Expect = 0.0
Identities = 484/708 (68%), Positives = 519/708 (73%), Gaps = 82/708 (11%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--------------------- 39
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE+
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
Query: 40 -------TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
T + + ++ +++ RC + W K+G +R IG
Sbjct: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGG 117
Query: 91 Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
Y L ++ P D G Y C S + ++V +
Sbjct: 118 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVE---------------- 161
Query: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEF 198
R+P+ + + V+F C + P ++W+K NG ++
Sbjct: 162 ---------RSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKY 212
Query: 199 KQEH-------RIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVV-- 249
+ + G N L + +V +D G Y C V N G N + L V+
Sbjct: 213 GPDGLPYLKVLKHSGINSSNAE-VLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK 271
Query: 250 --APGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLT 307
APGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLT
Sbjct: 272 QQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLT 331
Query: 308 KRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRD 367
KRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRD
Sbjct: 332 KRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRD 391
Query: 368 KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK 427
KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK
Sbjct: 392 KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK 451
Query: 428 MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT 487
MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT
Sbjct: 452 MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT 511
Query: 488 FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKK 547
FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKK
Sbjct: 512 FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKK 571
Query: 548 TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG 607
TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG
Sbjct: 572 TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG 631
Query: 608 HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 655
HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE
Sbjct: 632 HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 679
>gi|222144231 fibroblast growth factor receptor 2 isoform 3
precursor [Homo sapiens]
Length = 769
Score = 842 bits (2176), Expect = 0.0
Identities = 428/496 (86%), Positives = 442/496 (89%), Gaps = 16/496 (3%)
Query: 175 VKFRCPAGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLIMESVVP 223
V+F C + P ++W+K NG ++ + + G N L + +V
Sbjct: 274 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAE-VLALFNVTE 332
Query: 224 SDKGNYTCVVENEYGSINHTYHLDVV----APGREKEITASPDYLEIAIYCIGVFLIACM 279
+D G Y C V N G N + L V+ APGREKEITASPDYLEIAIYCIGVFLIACM
Sbjct: 333 ADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACM 392
Query: 280 VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRL 339
VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRL
Sbjct: 393 VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRL 452
Query: 340 SSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA 399
SSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA
Sbjct: 453 SSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA 512
Query: 400 VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 459
VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN
Sbjct: 513 VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 572
Query: 460 LREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARN 519
LREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARN
Sbjct: 573 LREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARN 632
Query: 520 VLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV 579
VLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV
Sbjct: 633 VLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV 692
Query: 580 LMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFK 639
LMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFK
Sbjct: 693 LMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFK 752
Query: 640 QLVEDLDRILTLTTNE 655
QLVEDLDRILTLTTNE
Sbjct: 753 QLVEDLDRILTLTTNE 768
Score = 518 bits (1334), Expect = e-147
Identities = 249/249 (100%), Positives = 249/249 (100%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
Query: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
Sbjct: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
Sbjct: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
Query: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
Sbjct: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
Query: 241 NHTYHLDVV 249
NHTYHLDVV
Sbjct: 241 NHTYHLDVV 249
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 825 bits (2132), Expect = 0.0
Identities = 427/665 (64%), Positives = 499/665 (75%), Gaps = 38/665 (5%)
Query: 46 QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
Q E V G+++E+ C + W KDG L P+ R ++ + LQ+ A+ DS
Sbjct: 45 QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104
Query: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
G Y+C R +F V VTDA SSGDDED D AED + APYWT E+M
Sbjct: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159
Query: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219
Query: 223 PSDKGNYTCVVENEYGSINHTYHLDVVA------------PGREKEITASPDYLEIAIYC 270
PSD+GNYTCVVEN++GSI TY LDV+ P + + S ++ +C
Sbjct: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGS----DVEFHC 275
Query: 271 IGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNT 330
+ + + + PD + V K VS ES++SM+SNT
Sbjct: 276 KVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLK------------VSLESNASMSSNT 323
Query: 331 PLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVG 390
PLVRI RLSS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+G
Sbjct: 324 PLVRIA-RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIG 381
Query: 391 IDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYV 450
IDKD+ + VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV
Sbjct: 382 IDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYV 441
Query: 451 IVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKC 510
+VEYA+KGNLRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKC
Sbjct: 442 LVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKC 501
Query: 511 IHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTH 570
IHRDLAARNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTH
Sbjct: 502 IHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTH 561
Query: 571 QSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHA 630
QSDVWSFGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA
Sbjct: 562 QSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHA 621
Query: 631 VPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDP 690
PSQRPTFKQLVEDLDR+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+ D
Sbjct: 622 APSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDL 681
Query: 691 MPYEP 695
+P P
Sbjct: 682 LPPAP 686
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 788 bits (2036), Expect = 0.0
Identities = 430/760 (56%), Positives = 518/760 (68%), Gaps = 83/760 (10%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEE---------------------PP 39
M SW + V+ ATL ARPS +L E L E P
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60
Query: 40 TKYQIS----QPEVYVAAPGESLEVRCLLKDAA--VISWTKDGVHLGPNNRTVLIGEYLQ 93
Y S + +++ ++++ +C + W K+G P++R IG Y +
Sbjct: 61 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHR---IGGY-K 116
Query: 94 IKGAT---------PRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFV 144
++ AT P D G Y C S + ++V +
Sbjct: 117 VRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVE------------------ 158
Query: 145 SENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEFKQ 200
R+P+ + V + V+F C +P P ++WLK NG +
Sbjct: 159 -------RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGP 211
Query: 201 EH-------RIGGYKVRNQHWSLI-MESVVPSDKGNYTCVVENEYGSINHTYHLDVVAPG 252
++ + G ++ ++ + +V D G YTC+ N G +H+ L V+
Sbjct: 212 DNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEAL 271
Query: 253 REKE-ITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIP 311
E+ + SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK DF SQ AVHKL K IP
Sbjct: 272 EERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIP 331
Query: 312 LRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTL 371
LRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYELPEDP+WE PRD+L L
Sbjct: 332 LRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPEDPRWELPRDRLVL 389
Query: 372 GKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGK 431
GKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDLSDL+SEMEMMKMIGK
Sbjct: 390 GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK 449
Query: 432 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDL 491
HKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ + PEEQ++ KDL
Sbjct: 450 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 509
Query: 492 VSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNG 551
VSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI++IDYYKKTTNG
Sbjct: 510 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 569
Query: 552 RLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMD 611
RLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEELFKLLKEGHRMD
Sbjct: 570 RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMD 629
Query: 612 KPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSY 671
KP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+N+EYLDLS PL+QYSPS+
Sbjct: 630 KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSF 689
Query: 672 PDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--INGSVK 708
PDTRSS CSSG+DSVFS +P+P EPCLP++P NG +K
Sbjct: 690 PDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLK 729
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 788 bits (2035), Expect = 0.0
Identities = 430/762 (56%), Positives = 518/762 (67%), Gaps = 85/762 (11%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTL----------------------EPEEP 38
M SW + V+ ATL ARPS +L E L +P
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM 60
Query: 39 PTKYQISQPE-----VYVAAPGESLEVRCLLKDAA--VISWTKDGVHLGPNNRTVLIGEY 91
P + PE ++ ++++ +C + W K+G P++R IG Y
Sbjct: 61 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHR---IGGY 117
Query: 92 LQIKGAT---------PRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
+++ AT P D G Y C S + ++V +
Sbjct: 118 -KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVE---------------- 160
Query: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEF 198
R+P+ + V + V+F C +P P ++WLK NG +
Sbjct: 161 ---------RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI 211
Query: 199 KQEH-------RIGGYKVRNQHWSLI-MESVVPSDKGNYTCVVENEYGSINHTYHLDVVA 250
++ + G ++ ++ + +V D G YTC+ N G +H+ L V+
Sbjct: 212 GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE 271
Query: 251 PGREKE-ITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKR 309
E+ + SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK DF SQ AVHKL K
Sbjct: 272 ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS 331
Query: 310 IPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKL 369
IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYELPEDP+WE PRD+L
Sbjct: 332 IPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPEDPRWELPRDRL 389
Query: 370 TLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMI 429
LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDLSDL+SEMEMMKMI
Sbjct: 390 VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMI 449
Query: 430 GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFK 489
GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ + PEEQ++ K
Sbjct: 450 GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSK 509
Query: 490 DLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTT 549
DLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI++IDYYKKTT
Sbjct: 510 DLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTT 569
Query: 550 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHR 609
NGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEELFKLLKEGHR
Sbjct: 570 NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHR 629
Query: 610 MDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSP 669
MDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+N+EYLDLS PL+QYSP
Sbjct: 630 MDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSP 689
Query: 670 SYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--INGSVK 708
S+PDTRSS CSSG+DSVFS +P+P EPCLP++P NG +K
Sbjct: 690 SFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLK 731
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 782 bits (2019), Expect = 0.0
Identities = 411/664 (61%), Positives = 487/664 (73%), Gaps = 56/664 (8%)
Query: 70 ISWTKDGVHLGPNNRTVLIGEYLQIKGAT---------PRDSGLYACTASRTVDSETWYF 120
+ W K+G P++R IG Y +++ AT P D G Y C S +
Sbjct: 186 LRWLKNGKEFKPDHR---IGGY-KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTY 241
Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
++V + R+P+ + V + V+F C
Sbjct: 242 QLDVVE-------------------------RSPHRPILQAGLPANKTVALGSNVEFMCK 276
Query: 181 AGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLI-MESVVPSDKGN 228
+P P ++WLK NG + ++ + G ++ ++ + +V D G
Sbjct: 277 VYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGE 336
Query: 229 YTCVVENEYGSINHTYHLDVVAPGREKE-ITASPDYLEIAIYCIGVFLIACMVVTVILCR 287
YTC+ N G +H+ L V+ E+ + SP YLEI IYC G FLI+CMV +VI+ +
Sbjct: 337 YTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYK 396
Query: 288 MKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPM 347
MK+ TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPM
Sbjct: 397 MKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPM 454
Query: 348 LAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKML 407
LAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKML
Sbjct: 455 LAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML 514
Query: 408 KDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRAR 467
K DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+AR
Sbjct: 515 KSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQAR 574
Query: 468 RPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV 527
RPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NV
Sbjct: 575 RPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV 634
Query: 528 MKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTL 587
MKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTL
Sbjct: 635 MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTL 694
Query: 588 GGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR 647
GGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR
Sbjct: 695 GGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR 754
Query: 648 ILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--IN 704
I+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP++P N
Sbjct: 755 IVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLAN 814
Query: 705 GSVK 708
G +K
Sbjct: 815 GGLK 818
Score = 272 bits (696), Expect = 7e-73
Identities = 138/253 (54%), Positives = 173/253 (68%), Gaps = 11/253 (4%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
M SW + V+ ATL ARPS +L E +P P + E ++ PG+ L++
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAPVEV-----ESFLVHPGDLLQL 53
Query: 61 RCLLKD-AAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWY 119
RC L+D I+W +DGV L +NRT + GE ++++ + P DSGLYAC S S+T Y
Sbjct: 54 RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTY 113
Query: 120 FMVNVTDAISSGDDEDDTDGAEDFVSENSNNKR---APYWTNTEKMEKRLHAVPAANTVK 176
F VNV+DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA TVK
Sbjct: 114 FSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVK 173
Query: 177 FRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
F+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VENE
Sbjct: 174 FKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENE 233
Query: 237 YGSINHTYHLDVV 249
YGSINHTY LDVV
Sbjct: 234 YGSINHTYQLDVV 246
>gi|105990522 fibroblast growth factor receptor 1 isoform 1
precursor [Homo sapiens]
Length = 822
Score = 782 bits (2019), Expect = 0.0
Identities = 411/664 (61%), Positives = 487/664 (73%), Gaps = 56/664 (8%)
Query: 70 ISWTKDGVHLGPNNRTVLIGEYLQIKGAT---------PRDSGLYACTASRTVDSETWYF 120
+ W K+G P++R IG Y +++ AT P D G Y C S +
Sbjct: 188 LRWLKNGKEFKPDHR---IGGY-KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTY 243
Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
++V + R+P+ + V + V+F C
Sbjct: 244 QLDVVE-------------------------RSPHRPILQAGLPANKTVALGSNVEFMCK 278
Query: 181 AGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLI-MESVVPSDKGN 228
+P P ++WLK NG + ++ + G ++ ++ + +V D G
Sbjct: 279 VYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGE 338
Query: 229 YTCVVENEYGSINHTYHLDVVAPGREKE-ITASPDYLEIAIYCIGVFLIACMVVTVILCR 287
YTC+ N G +H+ L V+ E+ + SP YLEI IYC G FLI+CMV +VI+ +
Sbjct: 339 YTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYK 398
Query: 288 MKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPM 347
MK+ TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPM
Sbjct: 399 MKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPM 456
Query: 348 LAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKML 407
LAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKML
Sbjct: 457 LAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML 516
Query: 408 KDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRAR 467
K DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+AR
Sbjct: 517 KSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQAR 576
Query: 468 RPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV 527
RPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NV
Sbjct: 577 RPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV 636
Query: 528 MKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTL 587
MKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTL
Sbjct: 637 MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTL 696
Query: 588 GGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR 647
GGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR
Sbjct: 697 GGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR 756
Query: 648 ILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--IN 704
I+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP++P N
Sbjct: 757 IVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLAN 816
Query: 705 GSVK 708
G +K
Sbjct: 817 GGLK 820
Score = 271 bits (694), Expect = 1e-72
Identities = 138/255 (54%), Positives = 173/255 (67%), Gaps = 13/255 (5%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
M SW + V+ ATL ARPS +L E +P P + E ++ PG+ L++
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAPVEV-----ESFLVHPGDLLQL 53
Query: 61 RCLLKD-AAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWY 119
RC L+D I+W +DGV L +NRT + GE ++++ + P DSGLYAC S S+T Y
Sbjct: 54 RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTY 113
Query: 120 FMVNVTDAISSGDDEDDTDGAEDFVSENSNNKR-----APYWTNTEKMEKRLHAVPAANT 174
F VNV+DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA T
Sbjct: 114 FSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKT 173
Query: 175 VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 234
VKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VE
Sbjct: 174 VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE 233
Query: 235 NEYGSINHTYHLDVV 249
NEYGSINHTY LDVV
Sbjct: 234 NEYGSINHTYQLDVV 248
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 690 bits (1781), Expect = 0.0
Identities = 357/536 (66%), Positives = 416/536 (77%), Gaps = 23/536 (4%)
Query: 175 VKFRCPAGGNPMPTMRWLKN-----------GKEFKQEHRIGGYKVRNQHWSLI-MESVV 222
V+F C + P ++WLK+ G + + G ++ ++ + +V
Sbjct: 271 VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVT 330
Query: 223 PSDKGNYTCVVENEYGSINHTYHLDVVAPGREKEITASPD---YLEIAIYCIGVFLIACM 279
D G YTC+ N G +H+ L VV P E+ + A Y I Y +G FL +
Sbjct: 331 FEDAGEYTCLAGNSIGFSHHSAWL-VVLPAEEELVEADEAGSVYAGILSYGVGFFLFILV 389
Query: 280 VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRL 339
V V LCR+++ KK P VHK++ R PL+RQV S ES++SM+SNTPLVRI RL
Sbjct: 390 VAAVTLCRLRSPPKKG--LGSPTVHKIS-RFPLKRQV--SLESNASMSSNTPLVRIA-RL 443
Query: 340 SSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA 399
SS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GIDKD+ +
Sbjct: 444 SS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKP 502
Query: 400 VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 459
VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KGN
Sbjct: 503 VTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGN 562
Query: 460 LREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARN 519
LRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLAARN
Sbjct: 563 LREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARN 622
Query: 520 VLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV 579
VLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV
Sbjct: 623 VLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV 682
Query: 580 LMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFK 639
L+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRPTFK
Sbjct: 683 LLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFK 742
Query: 640 QLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 695
QLVEDLDR+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+ D +P P
Sbjct: 743 QLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAP 798
Score = 212 bits (540), Expect = 8e-55
Identities = 109/207 (52%), Positives = 138/207 (66%), Gaps = 8/207 (3%)
Query: 46 QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
Q E V G+++E+ C + W KDG L P+ R ++ + LQ+ A+ DS
Sbjct: 45 QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104
Query: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
G Y+C R +F V VTDA SSGDDED D AED + APYWT E+M
Sbjct: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159
Query: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219
Query: 223 PSDKGNYTCVVENEYGSINHTYHLDVV 249
PSD+GNYTCVVEN++GSI TY LDV+
Sbjct: 220 PSDRGNYTCVVENKFGSIRQTYTLDVL 246
>gi|13186249 fibroblast growth factor receptor 1 isoform 9 precursor
[Homo sapiens]
Length = 785
Score = 683 bits (1762), Expect = 0.0
Identities = 375/664 (56%), Positives = 450/664 (67%), Gaps = 93/664 (14%)
Query: 70 ISWTKDGVHLGPNNRTVLIGEYLQIKGAT---------PRDSGLYACTASRTVDSETWYF 120
+ W K+G P++R IG Y +++ AT P D G Y C S +
Sbjct: 188 LRWLKNGKEFKPDHR---IGGY-KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTY 243
Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
++V + R+P+ + V + V+F C
Sbjct: 244 QLDVVE-------------------------RSPHRPILQAGLPANKTVALGSNVEFMCK 278
Query: 181 AGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLI-MESVVPSDKGN 228
+P P ++WLK NG + ++ + G ++ ++ + +V D G
Sbjct: 279 VYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGE 338
Query: 229 YTCVVENEYGSINHTYHLDVVAPGREKE-ITASPDYLEIAIYCIGVFLIACMVVTVILCR 287
YTC+ N G +H+ L V+ E+ + SP YLEI IYC G FLI+CMV +VI+ +
Sbjct: 339 YTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYK 398
Query: 288 MKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPM 347
MK+ TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPM
Sbjct: 399 MKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPM 456
Query: 348 LAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKML 407
LAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKML
Sbjct: 457 LAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML 516
Query: 408 KDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRAR 467
K DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+AR
Sbjct: 517 KSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQAR 576
Query: 468 RPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV 527
RPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NV
Sbjct: 577 RPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV 636
Query: 528 MKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTL 587
MKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTL
Sbjct: 637 MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTL 696
Query: 588 GGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR 647
GGSPYPG+PVEEL FKQLVEDLDR
Sbjct: 697 GGSPYPGVPVEEL-------------------------------------FKQLVEDLDR 719
Query: 648 ILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--IN 704
I+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP++P N
Sbjct: 720 IVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLAN 779
Query: 705 GSVK 708
G +K
Sbjct: 780 GGLK 783
Score = 271 bits (694), Expect = 1e-72
Identities = 138/255 (54%), Positives = 173/255 (67%), Gaps = 13/255 (5%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
M SW + V+ ATL ARPS +L E +P P + E ++ PG+ L++
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAPVEV-----ESFLVHPGDLLQL 53
Query: 61 RCLLKD-AAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWY 119
RC L+D I+W +DGV L +NRT + GE ++++ + P DSGLYAC S S+T Y
Sbjct: 54 RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTY 113
Query: 120 FMVNVTDAISSGDDEDDTDGAEDFVSENSNNKR-----APYWTNTEKMEKRLHAVPAANT 174
F VNV+DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA T
Sbjct: 114 FSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKT 173
Query: 175 VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 234
VKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VE
Sbjct: 174 VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE 233
Query: 235 NEYGSINHTYHLDVV 249
NEYGSINHTY LDVV
Sbjct: 234 NEYGSINHTYQLDVV 248
>gi|254028242 fibroblast growth factor receptor 3 isoform 3
precursor [Homo sapiens]
Length = 808
Score = 681 bits (1758), Expect = 0.0
Identities = 357/539 (66%), Positives = 409/539 (75%), Gaps = 27/539 (5%)
Query: 175 VKFRCPAGGNPMPTMRWLK----NGKEFKQEHRIGGYKVRNQHW---------SLIMESV 221
V+F C + P ++WLK NG + + Y + W L + +V
Sbjct: 271 VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGT--PYVTVLKSWISESVEADVRLRLANV 328
Query: 222 VPSDKGNYTCVVENEYGSINHTYHLDVVAPGREKEITASPD-----YLEIAIYCIGVFLI 276
D G Y C N G + L V P +E D Y I Y +G FL
Sbjct: 329 SERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFLF 388
Query: 277 ACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRIT 336
+V V LCR+++ KK P VHK++ R PL+RQV S ES++SM+SNTPLVRI
Sbjct: 389 ILVVAAVTLCRLRSPPKKG--LGSPTVHKIS-RFPLKRQV--SLESNASMSSNTPLVRIA 443
Query: 337 TRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKP 396
RLSS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GIDKD+
Sbjct: 444 -RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRA 501
Query: 397 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 456
+ VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+
Sbjct: 502 AKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAA 561
Query: 457 KGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLA 516
KGNLRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLA
Sbjct: 562 KGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA 621
Query: 517 ARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 576
ARNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS
Sbjct: 622 ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 681
Query: 577 FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 636
FGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRP
Sbjct: 682 FGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRP 741
Query: 637 TFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 695
TFKQLVEDLDR+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+ D +P P
Sbjct: 742 TFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAP 800
Score = 212 bits (540), Expect = 8e-55
Identities = 109/207 (52%), Positives = 138/207 (66%), Gaps = 8/207 (3%)
Query: 46 QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
Q E V G+++E+ C + W KDG L P+ R ++ + LQ+ A+ DS
Sbjct: 45 QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104
Query: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
G Y+C R +F V VTDA SSGDDED D AED + APYWT E+M
Sbjct: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159
Query: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219
Query: 223 PSDKGNYTCVVENEYGSINHTYHLDVV 249
PSD+GNYTCVVEN++GSI TY LDV+
Sbjct: 220 PSDRGNYTCVVENKFGSIRQTYTLDVL 246
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 569 bits (1467), Expect = e-162
Identities = 333/682 (48%), Positives = 421/682 (61%), Gaps = 60/682 (8%)
Query: 35 PEEPP--TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
P++ P T Q + +++ G +++ RC I W KDG NR IG
Sbjct: 143 PQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENR---IGG 199
Query: 91 Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
L ++ P D G Y C V S + ++++V +
Sbjct: 200 IRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLE---------------- 243
Query: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEF 198
R+P+ + + V+ C + P ++WLK NG F
Sbjct: 244 ---------RSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSF 294
Query: 199 KQEH--RIGGYKVRNQHWS----LIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVAPG 252
+ + K + + S L + +V D G YTC+ N G + L V+
Sbjct: 295 GADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEE 354
Query: 253 REKEITASPD--YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRI 310
A+P+ Y +I +Y G +A +++ L R + + PA + R
Sbjct: 355 DPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGR--HPRPPATVQKLSRF 412
Query: 311 PLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT 370
PL RQ S ES SS S++ LVR RLSS+ +LAG+ +LP DP WEFPRD+L
Sbjct: 413 PLARQF--SLESGSSGKSSSSLVR-GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLV 468
Query: 371 LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG 430
LGKPLGEGCFGQVV AEA G+D +P +A TVAVKMLKD+A++KDL+DLVSEME+MK+IG
Sbjct: 469 LGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIG 528
Query: 431 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 490
+HKNIINLLG CTQ+GPLYVIVE A+KGNLRE+LRARRPPG + S D R E ++F
Sbjct: 529 RHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPV 588
Query: 491 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN 550
LVSC YQ+ARGM+YL S+KCIHRDLAARNVLVTE+NVMKIADFGLAR +++IDYYKKT+N
Sbjct: 589 LVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSN 648
Query: 551 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM 610
GRLPVKWMAPEALFDRVYTHQSDVWSFG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRM
Sbjct: 649 GRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRM 708
Query: 611 DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPS 670
D+P +C ELY +MR+CWHA PSQRPTFKQLVE LD++L L +EEYLDL YSPS
Sbjct: 709 DRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPS 767
Query: 671 YPDTRSSCSSGDDSVFSPDPMP 692
D S+CSS DSVFS DP+P
Sbjct: 768 GGDASSTCSS-SDSVFSHDPLP 788
Score = 184 bits (467), Expect = 2e-46
Identities = 100/230 (43%), Positives = 140/230 (60%), Gaps = 12/230 (5%)
Query: 24 SFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNN 83
S E+ LEP P+ Q Q + A G+ + + C + W K+G L P
Sbjct: 21 SLEASEEVELEPCLAPSLEQ--QEQELTVALGQPVRLCCGRAERGG-HWYKEGSRLAPAG 77
Query: 84 RTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVT----DAISSGDDEDDTDG 139
R L+I P D+G Y C A ++ + N+T D+++S +D++D
Sbjct: 78 RVRGWRGRLEIASFLPEDAGRYLCLARGSM-----IVLQNLTLITGDSLTSSNDDEDPKS 132
Query: 140 AEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFK 199
D + +S ++APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F
Sbjct: 133 HRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFH 192
Query: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVV 249
E+RIGG ++R+QHWSL+MESVVPSD+G YTC+VEN GSI + Y LDV+
Sbjct: 193 GENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVL 242
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 569 bits (1467), Expect = e-162
Identities = 333/682 (48%), Positives = 421/682 (61%), Gaps = 60/682 (8%)
Query: 35 PEEPP--TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
P++ P T Q + +++ G +++ RC I W KDG NR IG
Sbjct: 143 PQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENR---IGG 199
Query: 91 Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
L ++ P D G Y C V S + ++++V +
Sbjct: 200 IRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLE---------------- 243
Query: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEF 198
R+P+ + + V+ C + P ++WLK NG F
Sbjct: 244 ---------RSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSF 294
Query: 199 KQEH--RIGGYKVRNQHWS----LIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVAPG 252
+ + K + + S L + +V D G YTC+ N G + L V+
Sbjct: 295 GADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEE 354
Query: 253 REKEITASPD--YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRI 310
A+P+ Y +I +Y G +A +++ L R + + PA + R
Sbjct: 355 DPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGR--HPRPPATVQKLSRF 412
Query: 311 PLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT 370
PL RQ S ES SS S++ LVR RLSS+ +LAG+ +LP DP WEFPRD+L
Sbjct: 413 PLARQF--SLESGSSGKSSSSLVR-GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLV 468
Query: 371 LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG 430
LGKPLGEGCFGQVV AEA G+D +P +A TVAVKMLKD+A++KDL+DLVSEME+MK+IG
Sbjct: 469 LGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIG 528
Query: 431 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 490
+HKNIINLLG CTQ+GPLYVIVE A+KGNLRE+LRARRPPG + S D R E ++F
Sbjct: 529 RHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPV 588
Query: 491 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN 550
LVSC YQ+ARGM+YL S+KCIHRDLAARNVLVTE+NVMKIADFGLAR +++IDYYKKT+N
Sbjct: 589 LVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSN 648
Query: 551 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM 610
GRLPVKWMAPEALFDRVYTHQSDVWSFG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRM
Sbjct: 649 GRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRM 708
Query: 611 DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPS 670
D+P +C ELY +MR+CWHA PSQRPTFKQLVE LD++L L +EEYLDL YSPS
Sbjct: 709 DRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPS 767
Query: 671 YPDTRSSCSSGDDSVFSPDPMP 692
D S+CSS DSVFS DP+P
Sbjct: 768 GGDASSTCSS-SDSVFSHDPLP 788
Score = 184 bits (467), Expect = 2e-46
Identities = 100/230 (43%), Positives = 140/230 (60%), Gaps = 12/230 (5%)
Query: 24 SFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNN 83
S E+ LEP P+ Q Q + A G+ + + C + W K+G L P
Sbjct: 21 SLEASEEVELEPCLAPSLEQ--QEQELTVALGQPVRLCCGRAERGG-HWYKEGSRLAPAG 77
Query: 84 RTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVT----DAISSGDDEDDTDG 139
R L+I P D+G Y C A ++ + N+T D+++S +D++D
Sbjct: 78 RVRGWRGRLEIASFLPEDAGRYLCLARGSM-----IVLQNLTLITGDSLTSSNDDEDPKS 132
Query: 140 AEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFK 199
D + +S ++APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F
Sbjct: 133 HRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFH 192
Query: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVV 249
E+RIGG ++R+QHWSL+MESVVPSD+G YTC+VEN GSI + Y LDV+
Sbjct: 193 GENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVL 242
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 544 bits (1401), Expect = e-154
Identities = 325/680 (47%), Positives = 404/680 (59%), Gaps = 96/680 (14%)
Query: 35 PEEPP--TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
P++ P T Q + +++ G +++ RC I W KDG NR IG
Sbjct: 143 PQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENR---IGG 199
Query: 91 Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
L ++ P D G Y C V S + ++++V +
Sbjct: 200 IRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLE---------------- 243
Query: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEF 198
R+P+ + + V+ C + P ++WLK NG F
Sbjct: 244 ---------RSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSF 294
Query: 199 KQEH--RIGGYKVRNQHWS----LIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVAPG 252
+ + K + + S L + +V D G YTC+ N G + L V+ PG
Sbjct: 295 GADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVL-PG 353
Query: 253 REKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPL 312
+ + D L A TK P
Sbjct: 354 TGRIPHLTCDSLTPA----------------------GRTKSPTLQ-------------- 377
Query: 313 RRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLG 372
S ES SS S++ LVR RLSS+ +LAG+ +LP DP WEFPRD+L LG
Sbjct: 378 -----FSLESGSSGKSSSSLVR-GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLG 430
Query: 373 KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH 432
KPLGEGCFGQVV AEA G+D +P +A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+H
Sbjct: 431 KPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRH 490
Query: 433 KNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 492
KNIINLLG CTQ+GPLYVIVE A+KGNLRE+LRARRPPG + S D R E ++F LV
Sbjct: 491 KNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLV 550
Query: 493 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 552
SC YQ+ARGM+YL S+KCIHRDLAARNVLVTE+NVMKIADFGLAR +++IDYYKKT+NGR
Sbjct: 551 SCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGR 610
Query: 553 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 612
LPVKWMAPEALFDRVYTHQSDVWSFG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+
Sbjct: 611 LPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDR 670
Query: 613 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYP 672
P +C ELY +MR+CWHA PSQRPTFKQLVE LD++L L +EEYLDL YSPS
Sbjct: 671 PPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGG 729
Query: 673 DTRSSCSSGDDSVFSPDPMP 692
D S+CSS DSVFS DP+P
Sbjct: 730 DASSTCSS-SDSVFSHDPLP 748
Score = 184 bits (467), Expect = 2e-46
Identities = 100/230 (43%), Positives = 140/230 (60%), Gaps = 12/230 (5%)
Query: 24 SFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNN 83
S E+ LEP P+ Q Q + A G+ + + C + W K+G L P
Sbjct: 21 SLEASEEVELEPCLAPSLEQ--QEQELTVALGQPVRLCCGRAERGG-HWYKEGSRLAPAG 77
Query: 84 RTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVT----DAISSGDDEDDTDG 139
R L+I P D+G Y C A ++ + N+T D+++S +D++D
Sbjct: 78 RVRGWRGRLEIASFLPEDAGRYLCLARGSM-----IVLQNLTLITGDSLTSSNDDEDPKS 132
Query: 140 AEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFK 199
D + +S ++APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F
Sbjct: 133 HRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFH 192
Query: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVV 249
E+RIGG ++R+QHWSL+MESVVPSD+G YTC+VEN GSI + Y LDV+
Sbjct: 193 GENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVL 242
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 329 bits (844), Expect = 5e-90
Identities = 177/368 (48%), Positives = 233/368 (63%), Gaps = 22/368 (5%)
Query: 322 SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 374
SS+ M P SS+ A P L V +++ EDPKWEFPR L LGK
Sbjct: 670 SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729
Query: 375 LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 433
LGEG FG+VV A A + K + TVAVKMLK++A+ +L DL+SE ++K + H
Sbjct: 730 LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785
Query: 434 NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 485
++I L GAC+QDGPL +IVEYA G+LR +LR R G Y S ++ E
Sbjct: 786 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845
Query: 486 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 545
+T DL+S +Q+++GM+YLA K +HRDLAARN+LV E MKI+DFGL+RD+ D Y
Sbjct: 846 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905
Query: 546 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 605
K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK
Sbjct: 906 VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965
Query: 606 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE 665
GHRM++P NC+ E+Y +M CW P +RP F + +DL+++ + +YLDL+
Sbjct: 966 TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLAASTP 1023
Query: 666 QYSPSYPD 673
S Y D
Sbjct: 1024 SDSLIYDD 1031
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 329 bits (844), Expect = 5e-90
Identities = 177/368 (48%), Positives = 233/368 (63%), Gaps = 22/368 (5%)
Query: 322 SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 374
SS+ M P SS+ A P L V +++ EDPKWEFPR L LGK
Sbjct: 670 SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729
Query: 375 LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 433
LGEG FG+VV A A + K + TVAVKMLK++A+ +L DL+SE ++K + H
Sbjct: 730 LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785
Query: 434 NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 485
++I L GAC+QDGPL +IVEYA G+LR +LR R G Y S ++ E
Sbjct: 786 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845
Query: 486 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 545
+T DL+S +Q+++GM+YLA K +HRDLAARN+LV E MKI+DFGL+RD+ D Y
Sbjct: 846 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905
Query: 546 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 605
K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK
Sbjct: 906 VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965
Query: 606 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE 665
GHRM++P NC+ E+Y +M CW P +RP F + +DL+++ + +YLDL+
Sbjct: 966 TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLAASTP 1023
Query: 666 QYSPSYPD 673
S Y D
Sbjct: 1024 SDSLIYDD 1031
>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [Homo
sapiens]
Length = 1338
Score = 322 bits (826), Expect = 6e-88
Identities = 218/625 (34%), Positives = 309/625 (49%), Gaps = 134/625 (21%)
Query: 92 LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNK 151
L I + +DSG YAC A E +T ++
Sbjct: 621 LTIMNVSLQDSGTYACRARNVYTGEEILQKKEIT----------------------IRDQ 658
Query: 152 RAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRN 211
APY H V +++ C A G P P + W KN + +QE G +
Sbjct: 659 EAPYLLRNLSD----HTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEP---GIILGP 711
Query: 212 QHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVAPGREKEITASPDYLEIAIYCI 271
+L +E V D+G Y C N+ GS+ + +L V + + + + + C+
Sbjct: 712 GSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNL----ELITLTCTCV 767
Query: 272 GVFLIACMVVTVILCRMKNTTK--KPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSN 329
L +++T+ + +MK ++ K D+ S + +PL Q
Sbjct: 768 AATLF-WLLLTLFIRKMKRSSSEIKTDYLS---IIMDPDEVPLDEQCE------------ 811
Query: 330 TPLVRITTRLSSTADTPMLAGVSEYELPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEA 388
LP D KWEF R++L LGK LG G FG+VV A A
Sbjct: 812 -------------------------RLPYDASKWEFARERLKLGKSLGRGAFGKVVQASA 846
Query: 389 VGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QDGP 447
GI K TVAVKMLK+ AT + L++E++++ IG H N++NLLGACT Q GP
Sbjct: 847 FGIKKSPTCR--TVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGP 904
Query: 448 LYVIVEYASKGNLREYLRARRP--------------------PGMEYSY----------- 476
L VIVEY GNL YL+++R PG+E
Sbjct: 905 LMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSE 964
Query: 477 -----------DINRVPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLA 516
++ V EE+ +T +DL+S ++Q+ARGME+L+S+KCIHRDLA
Sbjct: 965 SFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLA 1024
Query: 517 ARNVLVTENNVMKIADFGLARDI-NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 575
ARN+L++ENNV+KI DFGLARDI N DY +K RLP+KWMAPE++FD++Y+ +SDVW
Sbjct: 1025 ARNILLSENNVVKICDFGLARDIYKNPDYVRKGDT-RLPLKWMAPESIFDKIYSTKSDVW 1083
Query: 576 SFGVLMWEIFTLGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 634
S+GVL+WEIF+LGGSPYPG+ ++E F L+EG RM P T E+Y +M DCWH P +
Sbjct: 1084 SYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKE 1143
Query: 635 RPTFKQLVEDLDRILTLTTNEEYLD 659
RP F +LVE L +L ++ D
Sbjct: 1144 RPRFAELVEKLGDLLQANVQQDGKD 1168
Score = 35.8 bits (81), Expect = 0.14
Identities = 30/120 (25%), Positives = 53/120 (44%), Gaps = 11/120 (9%)
Query: 157 TNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
T + ++ L V + + P P + WLK+G + Y R +SL
Sbjct: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG--LPATEKSARYLTRG--YSL 390
Query: 217 IMESVVPSDKGNYTCVV----ENEYGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIG 272
I++ V D GNYT ++ N + ++ T ++V EK +++ PD A+Y +G
Sbjct: 391 IIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPD---PALYPLG 447
>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
Length = 1356
Score = 318 bits (816), Expect = 8e-87
Identities = 221/591 (37%), Positives = 303/591 (51%), Gaps = 116/591 (19%)
Query: 157 TNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
T T +E + ++ +++ C A GNP P + W K+ + ++ G +++ + +L
Sbjct: 668 TITGNLENQTTSI--GESIEVSCTASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNL 722
Query: 217 IMESVVPSDKGNYTCVVENEYGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLI 276
+ V D+G YTC + G ++ +EK LEI I +G +I
Sbjct: 723 TIRRVRKEDEGLYTCQACSVLGCAKVEAFF-IIEGAQEKT------NLEIIIL-VGTAVI 774
Query: 277 ACM--VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR 334
A ++ VI+ R TV + +
Sbjct: 775 AMFFWLLLVIILR-----------------------------TVKRANGGELK------- 798
Query: 335 ITTRLSSTADTPMLAGVSEYE-LPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGID 392
T LS D L E LP D KWEFPRD+L LGKPLG G FGQV+ A+A GID
Sbjct: 799 -TGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGID 857
Query: 393 KDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG-PLYVI 451
K TVAVKMLK+ AT + L+SE++++ IG H N++NLLGACT+ G PL VI
Sbjct: 858 KTATCR--TVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVI 915
Query: 452 VEYASKGNLREYLRARRPPGMEYS-----------------YDINR-------------- 480
VE+ GNL YLR++R + Y D+ R
Sbjct: 916 VEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASS 975
Query: 481 ----------VPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVL 521
V EE+ +T + L+ ++Q+A+GME+LAS+KCIHRDLAARN+L
Sbjct: 976 GFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNIL 1035
Query: 522 VTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLM 581
++E NV+KI DFGLARDI Y + + RLP+KWMAPE +FDRVYT QSDVWSFGVL+
Sbjct: 1036 LSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLL 1095
Query: 582 WEIFTLGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ 640
WEIF+LG SPYPG+ ++E F + LKEG RM P T E+Y M DCWH PSQRPTF +
Sbjct: 1096 WEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSE 1155
Query: 641 LVEDLDRILTLTTNEE-----YLDLSQPL---EQYSPSYPDTRSSCSSGDD 683
LVE L +L ++ L +S+ L E S P + SC ++
Sbjct: 1156 LVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEE 1206
Score = 38.5 bits (88), Expect = 0.022
Identities = 43/160 (26%), Positives = 61/160 (38%), Gaps = 37/160 (23%)
Query: 92 LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNK 151
L I G T D GLY C AS + ++ V V + + FV+ S
Sbjct: 292 LTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHE--------------KPFVAFGSG-- 335
Query: 152 RAPYWTNTEKMEKRLHAVPAANTVKFRCPAG--GNPMPTMRWLKNGKEFKQEHRIGGYKV 209
ME + A + R PA G P P ++W KNG + H I
Sbjct: 336 ----------MESLVEATVGE---RVRIPAKYLGYPPPEIKWYKNGIPLESNHTI----- 377
Query: 210 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVV 249
+ H IME V D GNYT ++ N ++ + +V
Sbjct: 378 KAGHVLTIME-VSERDTGNYTVILTNPISKEKQSHVVSLV 416
Score = 30.0 bits (66), Expect = 7.7
Identities = 16/55 (29%), Positives = 27/55 (49%), Gaps = 1/55 (1%)
Query: 70 ISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNV 124
I W K+G+ L +N T+ G L I + RD+G Y + + E +V++
Sbjct: 362 IKWYKNGIPL-ESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSL 415
>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 2 precursor [Homo sapiens]
Length = 972
Score = 289 bits (739), Expect = 7e-78
Identities = 164/403 (40%), Positives = 229/403 (56%), Gaps = 70/403 (17%)
Query: 355 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 414
+LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK A
Sbjct: 571 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 628
Query: 415 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 469
+ L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 629 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 688
Query: 470 ---------------------------------PGMEY----------SYDINRVPEEQM 486
PG+ Y S I E +
Sbjct: 689 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 748
Query: 487 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 534
T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T + KI DFG
Sbjct: 749 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 808
Query: 535 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 594
LARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 809 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 868
Query: 595 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 653
+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 869 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 928
Query: 654 NEEYLDLS-------QPLEQYSPSYPDTRSSCSSGDDSVFSPD 689
N Y +L+ +P+ +S S+ SS + D
Sbjct: 929 NHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDD 971
>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 1 precursor [Homo sapiens]
Length = 976
Score = 289 bits (739), Expect = 7e-78
Identities = 164/403 (40%), Positives = 229/403 (56%), Gaps = 70/403 (17%)
Query: 355 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 414
+LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK A
Sbjct: 575 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 632
Query: 415 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 469
+ L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 633 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 692
Query: 470 ---------------------------------PGMEY----------SYDINRVPEEQM 486
PG+ Y S I E +
Sbjct: 693 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 752
Query: 487 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 534
T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T + KI DFG
Sbjct: 753 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 812
Query: 535 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 594
LARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 813 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 872
Query: 595 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 653
+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 873 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 932
Query: 654 NEEYLDLS-------QPLEQYSPSYPDTRSSCSSGDDSVFSPD 689
N Y +L+ +P+ +S S+ SS + D
Sbjct: 933 NHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDD 975
>gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like
domains 1 [Homo sapiens]
Length = 1138
Score = 244 bits (624), Expect = 2e-64
Identities = 134/295 (45%), Positives = 186/295 (63%), Gaps = 10/295 (3%)
Query: 367 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 426
+ +T +GEG FGQV+ A I KD K + A+KMLK+ A+E D D E+E++
Sbjct: 837 EDITFEDLIGEGNFGQVIRAM---IKKDGLK--MNAAIKMLKEYASENDHRDFAGELEVL 891
Query: 427 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 486
+G H NIINLLGAC G LY+ +EYA GNL ++LR R + ++ +
Sbjct: 892 CKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTL 951
Query: 487 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYK 546
+ + L+ A GM+YL+ ++ IHRDLAARNVLV EN KIADFGL+R + Y
Sbjct: 952 SSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYV 1008
Query: 547 KTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKE 606
K T GRLPV+WMA E+L VYT +SDVWSFGVL+WEI +LGG+PY G+ EL++ L +
Sbjct: 1009 KKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQ 1068
Query: 607 GHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLS 661
G+RM++P NC +E+Y +MR CW P +RP F Q+ L R+ L + Y+++S
Sbjct: 1069 GYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRM--LEARKAYVNMS 1121
>gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens]
Length = 1124
Score = 244 bits (623), Expect = 2e-64
Identities = 128/275 (46%), Positives = 182/275 (66%), Gaps = 8/275 (2%)
Query: 375 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 434
+GEG FGQV+ A I KD + + A+K +K+ A++ D D E+E++ +G H N
Sbjct: 830 IGEGNFGQVLKAR---IKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
Query: 435 IINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSC 494
IINLLGAC G LY+ +EYA GNL ++LR R + ++ I ++ + L+
Sbjct: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
Query: 495 TYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP 554
+ARGM+YL+ ++ IHRDLAARN+LV EN V KIADFGL+R + Y K T GRLP
Sbjct: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLP 1001
Query: 555 VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 614
V+WMA E+L VYT SDVWS+GVL+WEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
Query: 615 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 649
NC +E+Y +MR CW P +RP+F Q++ L+R+L
Sbjct: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
>gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor
[Homo sapiens]
Length = 940
Score = 230 bits (587), Expect = 3e-60
Identities = 171/637 (26%), Positives = 287/637 (45%), Gaps = 71/637 (11%)
Query: 46 QPEVYVAAPGESLEVRCL----LKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRD 101
+P V+ A G V CL L + +V W GV L + R G L + D
Sbjct: 329 EPRVFTA--GSEERVTCLPPKGLPEPSVW-WEHAGVRLPTHGRVYQKGHELVLANIAESD 385
Query: 102 SGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDT-----------DGAEDFVSENSNN 150
+G+Y C A+ + V + S + D D A ++ SN
Sbjct: 386 AGVYTCHAANLAGQRRQDVNITVANGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNG 445
Query: 151 KRAPYWTNTE---------KMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQE 201
+ + + K+E V +T +C A G+P P ++W K
Sbjct: 446 PQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDP 504
Query: 202 HRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT----YHLDVVAPGREKEI 257
++G Q+ SL++ V P D G YTC+ N +I HT Y +D P +
Sbjct: 505 TKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSC-NIKHTEAPLYVVDKPVPEESEGP 563
Query: 258 TASPDYLEIAIYCIGVFLIACMVVTVI--------LCRMKNTTKKPDFSSQPAVHKLTKR 309
+ P Y I + V ++ V+ C+ K K+P+ +P + L
Sbjct: 564 GSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGG 622
Query: 310 IPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKL 369
Q + + ++ S T + ST+D K FPR L
Sbjct: 623 PLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD----------------KMHFPRSSL 666
Query: 370 TLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMI 429
LG+ FG+V +A+A G+++ + V V KD+ + D E+EM +
Sbjct: 667 QPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMFGKL 723
Query: 430 GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFK 489
H N++ LLG C + P Y+++EY G+L+++LR + ++ + ++ K
Sbjct: 724 N-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD-------EKLKSQPLSTK 775
Query: 490 DLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTT 549
V+ Q+A GME+L++ + +H+DLAARN LV+ +K++ GL++D+ N +YY
Sbjct: 776 QKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FR 834
Query: 550 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH- 608
+P++WM+PEA+ + ++ +SDVW+FGVLMWE+FT G P+ G +E+ L+ G
Sbjct: 835 QAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKA 894
Query: 609 RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 645
R+ +P C ++LY +M+ CW P RP+F ++ L
Sbjct: 895 RLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 931
Score = 38.5 bits (88), Expect = 0.022
Identities = 43/202 (21%), Positives = 66/202 (32%), Gaps = 36/202 (17%)
Query: 44 ISQPEVYVAAPGESLEVRCLLKDAAVIS--WTKDGVHLGPNNRTVLIGEYLQIKGATP-R 100
I QP A G +RC ++ + W DG + R G L +
Sbjct: 35 IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ 94
Query: 101 DSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTE 160
DSG + C A DD G E + S N + W
Sbjct: 95 DSGTFQCVA------------------------RDDVTGEEARSANASFNIK---WIEAG 127
Query: 161 KMEKRLHAVPAA----NTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
+ + A A V RC G+P PT +W ++G + V ++ +L
Sbjct: 128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNL 185
Query: 217 IMESVVPSDKGNYTCVVENEYG 238
+ P G Y+C + +G
Sbjct: 186 TLRPAGPEHSGLYSCCAHSAFG 207
Score = 34.7 bits (78), Expect = 0.31
Identities = 58/251 (23%), Positives = 91/251 (36%), Gaps = 67/251 (26%)
Query: 41 KYQISQPEVYVAAPGESLEVRCLLKD--AAVISWTKDGVHL--GPNNRTVLIGEY-LQIK 95
K+ S+ E+ P + +RC + W +DG L G +N TV E L ++
Sbjct: 132 KHPASEAEIQ---PQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLR 188
Query: 96 GATPRDSGLYACTASRTVDS--ETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 153
A P SGLY+C A + F +++ D E F + A
Sbjct: 189 PAGPEHSGLYSCCAHSAFGQACSSQNFTLSIAD--------------ESF----ARVVLA 230
Query: 154 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 213
P + E+ + F C P P+++WL F+ E I + R H
Sbjct: 231 PQDVVVARYEEAM----------FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPH 274
Query: 214 ---------WSLIMESVVPSDKGNYTCVVENEYGS---INHTYHL-----------DVVA 250
SL++ V P + G Y C+ + + G + T HL V
Sbjct: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFT 334
Query: 251 PGREKEITASP 261
G E+ +T P
Sbjct: 335 AGSEERVTCLP 345
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 228 bits (580), Expect = 2e-59
Identities = 115/285 (40%), Positives = 176/285 (61%), Gaps = 9/285 (3%)
Query: 361 KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLV 420
+WE R+K+T+ + LG+G FG V A G+ KD+P+ VA+K + + A+ ++ + +
Sbjct: 991 EWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPE--TRVAIKTVNEAASMRERIEFL 1048
Query: 421 SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINR 480
+E +MK H +++ LLG +Q P VI+E ++G+L+ YLR+ RP ME N
Sbjct: 1049 NEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPE-ME-----NN 1101
Query: 481 VPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDIN 540
+ ++ ++A GM YL + K +HRDLAARN +V E+ +KI DFG+ RDI
Sbjct: 1102 PVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY 1161
Query: 541 NIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEEL 600
DYY+K G LPV+WM+PE+L D V+T SDVWSFGV++WEI TL PY G+ E++
Sbjct: 1162 ETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQV 1221
Query: 601 FKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 645
+ + EG +DKP NC + L+ +MR CW P RP+F +++ +
Sbjct: 1222 LRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSI 1266
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,179,869
Number of Sequences: 37866
Number of extensions: 1363969
Number of successful extensions: 8736
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 669
Number of HSP's successfully gapped in prelim test: 333
Number of HSP's that attempted gapping in prelim test: 4110
Number of HSP's gapped (non-prelim): 2839
length of query: 709
length of database: 18,247,518
effective HSP length: 109
effective length of query: 600
effective length of database: 14,120,124
effective search space: 8472074400
effective search space used: 8472074400
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.