Guide to the Human Genome
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Search of human proteins with 222144233

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|222144233 fibroblast growth factor receptor 2 isoform 4
precursor [Homo sapiens]
         (709 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu...  1453   0.0  
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu...  1305   0.0  
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu...  1025   0.0  
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu...  1016   0.0  
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu...   959   0.0  
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu...   958   0.0  
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu...   901   0.0  
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu...   895   0.0  
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu...   842   0.0  
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur...   825   0.0  
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur...   788   0.0  
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur...   788   0.0  
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur...   782   0.0  
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu...   782   0.0  
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs...   690   0.0  
gi|13186249 fibroblast growth factor receptor 1 isoform 9 precur...   683   0.0  
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu...   681   0.0  
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur...   569   e-162
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur...   569   e-162
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur...   544   e-154
gi|10862701 ret proto-oncogene isoform c [Homo sapiens]               329   5e-90
gi|10862703 ret proto-oncogene isoform a [Homo sapiens]               329   5e-90
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [...   322   6e-88
gi|11321597 kinase insert domain receptor precursor [Homo sapiens]    318   8e-87
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge...   289   7e-78
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene...   289   7e-78
gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like...   244   2e-64
gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap...   244   2e-64
gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [...   230   3e-60
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo...   228   2e-59

>gi|222144233 fibroblast growth factor receptor 2 isoform 4
           precursor [Homo sapiens]
          Length = 709

 Score = 1453 bits (3762), Expect = 0.0
 Identities = 709/709 (100%), Positives = 709/709 (100%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
           MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
Sbjct: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60

Query: 61  RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
           RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
Sbjct: 61  RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120

Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
           MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
Sbjct: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180

Query: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
           AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
Sbjct: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240

Query: 241 NHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQ 300
           NHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQ
Sbjct: 241 NHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQ 300

Query: 301 PAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDP 360
           PAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDP
Sbjct: 301 PAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDP 360

Query: 361 KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLV 420
           KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLV
Sbjct: 361 KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLV 420

Query: 421 SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINR 480
           SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINR
Sbjct: 421 SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINR 480

Query: 481 VPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDIN 540
           VPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDIN
Sbjct: 481 VPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDIN 540

Query: 541 NIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEEL 600
           NIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEEL
Sbjct: 541 NIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEEL 600

Query: 601 FKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDL 660
           FKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDL
Sbjct: 601 FKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDL 660

Query: 661 SQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT 709
           SQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
Sbjct: 661 SQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT 709


>gi|222144239 fibroblast growth factor receptor 2 isoform 7
           precursor [Homo sapiens]
          Length = 705

 Score = 1305 bits (3377), Expect = 0.0
 Identities = 649/714 (90%), Positives = 658/714 (92%), Gaps = 14/714 (1%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
           MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
Sbjct: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60

Query: 61  RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
           RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
Sbjct: 61  RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120

Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
           MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
Sbjct: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180

Query: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
           AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
Sbjct: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240

Query: 241 NHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQ 300
           NHTYHLDVV     + I  +      +    G     C V +           +P     
Sbjct: 241 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYS---------DAQPHIQWI 291

Query: 301 PAVHKLTKR-----IPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYE 355
             V K   +     +P  + + VSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYE
Sbjct: 292 KHVEKNGSKYGPDGLPYLKVLKVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYE 351

Query: 356 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 415
           LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD
Sbjct: 352 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 411

Query: 416 LSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS 475
           LSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS
Sbjct: 412 LSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS 471

Query: 476 YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGL 535
           YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGL
Sbjct: 472 YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGL 531

Query: 536 ARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI 595
           ARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI
Sbjct: 532 ARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI 591

Query: 596 PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 655
           PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE
Sbjct: 592 PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 651

Query: 656 EYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT 709
           EYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
Sbjct: 652 EYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT 705


>gi|222144237 fibroblast growth factor receptor 2 isoform 6
           precursor [Homo sapiens]
          Length = 706

 Score = 1025 bits (2649), Expect = 0.0
 Identities = 537/734 (73%), Positives = 575/734 (78%), Gaps = 53/734 (7%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--TKYQISQPEVYVAAPGESL 58
           MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE  P  T  +  +  ++      ++
Sbjct: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60

Query: 59  EVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGEY--------LQIKGATPRDSGLYACT 108
           + RC         + W K+G      +R   IG Y        L ++   P D G Y C 
Sbjct: 61  KFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGGYKVRNQHWSLIMESVVPSDKGNYTCV 117

Query: 109 ASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHA 168
                 S    + ++V +                         R+P+    +       +
Sbjct: 118 VENEYGSINHTYHLDVVE-------------------------RSPHRPILQAGLPANAS 152

Query: 169 VPAANTVKFRCPAGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLI 217
                 V+F C    +  P ++W+K    NG ++  +        +  G    ++   ++
Sbjct: 153 TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVL 212

Query: 218 -MESVVPSDKGNYTCVVENEYGSINHTYHLDVV-APGREKEITASPDYLEIAIYCIGVFL 275
            + +V   D G YTC+  N  G   H+  L V+ APGREKEITASPDYLEIAIYCIGVFL
Sbjct: 213 YIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFL 272

Query: 276 IACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRI 335
           IACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRI
Sbjct: 273 IACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRI 332

Query: 336 TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 395
           TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK
Sbjct: 333 TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 392

Query: 396 PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA 455
           PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA
Sbjct: 393 PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA 452

Query: 456 SKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDL 515
           SKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDL
Sbjct: 453 SKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDL 512

Query: 516 AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 575
           AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW
Sbjct: 513 AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 572

Query: 576 SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR 635
           SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR
Sbjct: 573 SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR 632

Query: 636 PTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 695
           PTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP
Sbjct: 633 PTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 692

Query: 696 CLPQYPHINGSVKT 709
           CLPQYPHINGSVKT
Sbjct: 693 CLPQYPHINGSVKT 706


>gi|222144241 fibroblast growth factor receptor 2 isoform 8
           precursor [Homo sapiens]
          Length = 704

 Score = 1016 bits (2627), Expect = 0.0
 Identities = 535/734 (72%), Positives = 573/734 (78%), Gaps = 55/734 (7%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--TKYQISQPEVYVAAPGESL 58
           MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE  P  T  +  +  ++      ++
Sbjct: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60

Query: 59  EVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGEY--------LQIKGATPRDSGLYACT 108
           + RC         + W K+G      +R   IG Y        L ++   P D G Y C 
Sbjct: 61  KFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGGYKVRNQHWSLIMESVVPSDKGNYTCV 117

Query: 109 ASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHA 168
                 S    + ++V +                         R+P+    +       +
Sbjct: 118 VENEYGSINHTYHLDVVE-------------------------RSPHRPILQAGLPANAS 152

Query: 169 VPAANTVKFRCPAGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLI 217
                 V+F C    +  P ++W+K    NG ++  +        +  G    ++   ++
Sbjct: 153 TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVL 212

Query: 218 -MESVVPSDKGNYTCVVENEYGSINHTYHLDVV-APGREKEITASPDYLEIAIYCIGVFL 275
            + +V   D G YTC+  N  G   H+  L V+ APGREKEITASPDYLEIAIYCIGVFL
Sbjct: 213 YIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFL 272

Query: 276 IACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRI 335
           IACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV  SAESSSSMNSNTPLVRI
Sbjct: 273 IACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV--SAESSSSMNSNTPLVRI 330

Query: 336 TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 395
           TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK
Sbjct: 331 TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 390

Query: 396 PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA 455
           PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA
Sbjct: 391 PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA 450

Query: 456 SKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDL 515
           SKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDL
Sbjct: 451 SKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDL 510

Query: 516 AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 575
           AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW
Sbjct: 511 AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 570

Query: 576 SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR 635
           SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR
Sbjct: 571 SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR 630

Query: 636 PTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 695
           PTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP
Sbjct: 631 PTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 690

Query: 696 CLPQYPHINGSVKT 709
           CLPQYPHINGSVKT
Sbjct: 691 CLPQYPHINGSVKT 704


>gi|221316639 fibroblast growth factor receptor 2 isoform 1
           precursor [Homo sapiens]
          Length = 821

 Score =  959 bits (2479), Expect = 0.0
 Identities = 480/548 (87%), Positives = 498/548 (90%), Gaps = 13/548 (2%)

Query: 175 VKFRCPAGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLI-MESVV 222
           V+F C    +  P ++W+K    NG ++  +        +  G    ++   ++ + +V 
Sbjct: 274 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVT 333

Query: 223 PSDKGNYTCVVENEYGSINHTYHLDVV-APGREKEITASPDYLEIAIYCIGVFLIACMVV 281
             D G YTC+  N  G   H+  L V+ APGREKEITASPDYLEIAIYCIGVFLIACMVV
Sbjct: 334 FEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVV 393

Query: 282 TVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSS 341
           TVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSS
Sbjct: 394 TVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSS 453

Query: 342 TADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVT 401
           TADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVT
Sbjct: 454 TADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVT 513

Query: 402 VAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR 461
           VAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR
Sbjct: 514 VAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR 573

Query: 462 EYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVL 521
           EYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVL
Sbjct: 574 EYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVL 633

Query: 522 VTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLM 581
           VTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLM
Sbjct: 634 VTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLM 693

Query: 582 WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQL 641
           WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQL
Sbjct: 694 WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQL 753

Query: 642 VEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYP 701
           VEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYP
Sbjct: 754 VEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYP 813

Query: 702 HINGSVKT 709
           HINGSVKT
Sbjct: 814 HINGSVKT 821



 Score =  518 bits (1334), Expect = e-147
 Identities = 249/249 (100%), Positives = 249/249 (100%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
           MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
Sbjct: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60

Query: 61  RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
           RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
Sbjct: 61  RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120

Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
           MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
Sbjct: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180

Query: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
           AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
Sbjct: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240

Query: 241 NHTYHLDVV 249
           NHTYHLDVV
Sbjct: 241 NHTYHLDVV 249


>gi|221316638 fibroblast growth factor receptor 2 isoform 2
           precursor [Homo sapiens]
          Length = 822

 Score =  958 bits (2477), Expect = 0.0
 Identities = 482/550 (87%), Positives = 496/550 (90%), Gaps = 16/550 (2%)

Query: 175 VKFRCPAGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLIMESVVP 223
           V+F C    +  P ++W+K    NG ++  +        +  G    N    L + +V  
Sbjct: 274 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAE-VLALFNVTE 332

Query: 224 SDKGNYTCVVENEYGSINHTYHLDVV----APGREKEITASPDYLEIAIYCIGVFLIACM 279
           +D G Y C V N  G  N +  L V+    APGREKEITASPDYLEIAIYCIGVFLIACM
Sbjct: 333 ADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACM 392

Query: 280 VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRL 339
           VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRL
Sbjct: 393 VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRL 452

Query: 340 SSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA 399
           SSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA
Sbjct: 453 SSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA 512

Query: 400 VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 459
           VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN
Sbjct: 513 VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 572

Query: 460 LREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARN 519
           LREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARN
Sbjct: 573 LREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARN 632

Query: 520 VLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV 579
           VLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV
Sbjct: 633 VLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV 692

Query: 580 LMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFK 639
           LMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFK
Sbjct: 693 LMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFK 752

Query: 640 QLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQ 699
           QLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQ
Sbjct: 753 QLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQ 812

Query: 700 YPHINGSVKT 709
           YPHINGSVKT
Sbjct: 813 YPHINGSVKT 822



 Score =  518 bits (1334), Expect = e-147
 Identities = 249/249 (100%), Positives = 249/249 (100%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
           MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
Sbjct: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60

Query: 61  RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
           RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
Sbjct: 61  RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120

Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
           MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
Sbjct: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180

Query: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
           AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
Sbjct: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240

Query: 241 NHTYHLDVV 249
           NHTYHLDVV
Sbjct: 241 NHTYHLDVV 249


>gi|222144235 fibroblast growth factor receptor 2 isoform 5
           precursor [Homo sapiens]
          Length = 707

 Score =  901 bits (2328), Expect = 0.0
 Identities = 486/729 (66%), Positives = 530/729 (72%), Gaps = 79/729 (10%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--------------------- 39
           MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE+                       
Sbjct: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60

Query: 40  -------TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
                  T  +  +  ++      +++ RC         + W K+G      +R   IG 
Sbjct: 61  NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGG 117

Query: 91  Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
           Y        L ++   P D G Y C       S    + ++V +                
Sbjct: 118 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVE---------------- 161

Query: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEF 198
                    R+P+    +       +      V+F C    +  P ++W+K    NG ++
Sbjct: 162 ---------RSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKY 212

Query: 199 KQEH-------RIGGYKVRNQHWSLI-MESVVPSDKGNYTCVVENEYGSINHTYHLDVV- 249
             +        +  G    ++   ++ + +V   D G YTC+  N  G   H+  L V+ 
Sbjct: 213 GPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLP 272

Query: 250 APGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKR 309
           APGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKR
Sbjct: 273 APGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKR 332

Query: 310 IPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKL 369
           IPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKL
Sbjct: 333 IPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKL 392

Query: 370 TLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMI 429
           TLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMI
Sbjct: 393 TLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMI 452

Query: 430 GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFK 489
           GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFK
Sbjct: 453 GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFK 512

Query: 490 DLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTT 549
           DLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTT
Sbjct: 513 DLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTT 572

Query: 550 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHR 609
           NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHR
Sbjct: 573 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHR 632

Query: 610 MDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSP 669
           MDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEE   +S  ++ + P
Sbjct: 633 MDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEEKKVSGAVDCHKP 692

Query: 670 SYPDTRSSC 678
               +   C
Sbjct: 693 PCNPSHLPC 701


>gi|222144244 fibroblast growth factor receptor 2 isoform 9
           precursor [Homo sapiens]
          Length = 680

 Score =  895 bits (2314), Expect = 0.0
 Identities = 484/708 (68%), Positives = 519/708 (73%), Gaps = 82/708 (11%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--------------------- 39
           MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE+                       
Sbjct: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60

Query: 40  -------TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
                  T  +  +  ++      +++ RC         + W K+G      +R   IG 
Sbjct: 61  NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGG 117

Query: 91  Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
           Y        L ++   P D G Y C       S    + ++V +                
Sbjct: 118 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVE---------------- 161

Query: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEF 198
                    R+P+    +       +      V+F C    +  P ++W+K    NG ++
Sbjct: 162 ---------RSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKY 212

Query: 199 KQEH-------RIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVV-- 249
             +        +  G    N    L + +V  +D G Y C V N  G  N +  L V+  
Sbjct: 213 GPDGLPYLKVLKHSGINSSNAE-VLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK 271

Query: 250 --APGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLT 307
             APGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLT
Sbjct: 272 QQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLT 331

Query: 308 KRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRD 367
           KRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRD
Sbjct: 332 KRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRD 391

Query: 368 KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK 427
           KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK
Sbjct: 392 KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK 451

Query: 428 MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT 487
           MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT
Sbjct: 452 MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT 511

Query: 488 FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKK 547
           FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKK
Sbjct: 512 FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKK 571

Query: 548 TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG 607
           TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG
Sbjct: 572 TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG 631

Query: 608 HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 655
           HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE
Sbjct: 632 HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 679


>gi|222144231 fibroblast growth factor receptor 2 isoform 3
           precursor [Homo sapiens]
          Length = 769

 Score =  842 bits (2176), Expect = 0.0
 Identities = 428/496 (86%), Positives = 442/496 (89%), Gaps = 16/496 (3%)

Query: 175 VKFRCPAGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLIMESVVP 223
           V+F C    +  P ++W+K    NG ++  +        +  G    N    L + +V  
Sbjct: 274 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAE-VLALFNVTE 332

Query: 224 SDKGNYTCVVENEYGSINHTYHLDVV----APGREKEITASPDYLEIAIYCIGVFLIACM 279
           +D G Y C V N  G  N +  L V+    APGREKEITASPDYLEIAIYCIGVFLIACM
Sbjct: 333 ADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACM 392

Query: 280 VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRL 339
           VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRL
Sbjct: 393 VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRL 452

Query: 340 SSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA 399
           SSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA
Sbjct: 453 SSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA 512

Query: 400 VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 459
           VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN
Sbjct: 513 VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 572

Query: 460 LREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARN 519
           LREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARN
Sbjct: 573 LREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARN 632

Query: 520 VLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV 579
           VLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV
Sbjct: 633 VLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV 692

Query: 580 LMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFK 639
           LMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFK
Sbjct: 693 LMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFK 752

Query: 640 QLVEDLDRILTLTTNE 655
           QLVEDLDRILTLTTNE
Sbjct: 753 QLVEDLDRILTLTTNE 768



 Score =  518 bits (1334), Expect = e-147
 Identities = 249/249 (100%), Positives = 249/249 (100%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
           MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
Sbjct: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60

Query: 61  RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
           RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
Sbjct: 61  RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120

Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
           MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
Sbjct: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180

Query: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
           AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
Sbjct: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240

Query: 241 NHTYHLDVV 249
           NHTYHLDVV
Sbjct: 241 NHTYHLDVV 249


>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
           [Homo sapiens]
          Length = 694

 Score =  825 bits (2132), Expect = 0.0
 Identities = 427/665 (64%), Positives = 499/665 (75%), Gaps = 38/665 (5%)

Query: 46  QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
           Q E  V   G+++E+ C       +    W KDG  L P+ R ++  + LQ+  A+  DS
Sbjct: 45  QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104

Query: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
           G Y+C   R       +F V VTDA SSGDDED  D AED   +      APYWT  E+M
Sbjct: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159

Query: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
           +K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219

Query: 223 PSDKGNYTCVVENEYGSINHTYHLDVVA------------PGREKEITASPDYLEIAIYC 270
           PSD+GNYTCVVEN++GSI  TY LDV+             P  +  +  S    ++  +C
Sbjct: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGS----DVEFHC 275

Query: 271 IGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNT 330
                    +  +    +  +   PD +    V K            VS ES++SM+SNT
Sbjct: 276 KVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLK------------VSLESNASMSSNT 323

Query: 331 PLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVG 390
           PLVRI  RLSS  + P LA VSE ELP DPKWE  R +LTLGKPLGEGCFGQVVMAEA+G
Sbjct: 324 PLVRIA-RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIG 381

Query: 391 IDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYV 450
           IDKD+  + VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV
Sbjct: 382 IDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYV 441

Query: 451 IVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKC 510
           +VEYA+KGNLRE+LRARRPPG++YS+D  + PEEQ+TFKDLVSC YQ+ARGMEYLASQKC
Sbjct: 442 LVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKC 501

Query: 511 IHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTH 570
           IHRDLAARNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTH
Sbjct: 502 IHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTH 561

Query: 571 QSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHA 630
           QSDVWSFGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA
Sbjct: 562 QSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHA 621

Query: 631 VPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDP 690
            PSQRPTFKQLVEDLDR+LT+T+ +EYLDLS P EQYSP   DT SS SSGDDSVF+ D 
Sbjct: 622 APSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDL 681

Query: 691 MPYEP 695
           +P  P
Sbjct: 682 LPPAP 686


>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
           [Homo sapiens]
          Length = 731

 Score =  788 bits (2036), Expect = 0.0
 Identities = 430/760 (56%), Positives = 518/760 (68%), Gaps = 83/760 (10%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEE---------------------PP 39
           M SW   +   V+  ATL  ARPS +L E   L   E                     P 
Sbjct: 1   MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60

Query: 40  TKYQIS----QPEVYVAAPGESLEVRCLLKDAA--VISWTKDGVHLGPNNRTVLIGEYLQ 93
             Y  S    + +++     ++++ +C         + W K+G    P++R   IG Y +
Sbjct: 61  APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHR---IGGY-K 116

Query: 94  IKGAT---------PRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFV 144
           ++ AT         P D G Y C       S    + ++V +                  
Sbjct: 117 VRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVE------------------ 158

Query: 145 SENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEFKQ 200
                  R+P+    +        V   + V+F C    +P P ++WLK    NG +   
Sbjct: 159 -------RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGP 211

Query: 201 EH-------RIGGYKVRNQHWSLI-MESVVPSDKGNYTCVVENEYGSINHTYHLDVVAPG 252
           ++       +  G    ++   ++ + +V   D G YTC+  N  G  +H+  L V+   
Sbjct: 212 DNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEAL 271

Query: 253 REKE-ITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIP 311
            E+  +  SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK DF SQ AVHKL K IP
Sbjct: 272 EERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIP 331

Query: 312 LRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTL 371
           LRRQVTVSA+SS+SMNS   LVR  +RLSS+  TPMLAGVSEYELPEDP+WE PRD+L L
Sbjct: 332 LRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPEDPRWELPRDRLVL 389

Query: 372 GKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGK 431
           GKPLGEGCFGQVV+AEA+G+DKDKP     VAVKMLK DATEKDLSDL+SEMEMMKMIGK
Sbjct: 390 GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK 449

Query: 432 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDL 491
           HKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ +  PEEQ++ KDL
Sbjct: 450 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 509

Query: 492 VSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNG 551
           VSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI++IDYYKKTTNG
Sbjct: 510 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 569

Query: 552 RLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMD 611
           RLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEELFKLLKEGHRMD
Sbjct: 570 RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMD 629

Query: 612 KPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSY 671
           KP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+N+EYLDLS PL+QYSPS+
Sbjct: 630 KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSF 689

Query: 672 PDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--INGSVK 708
           PDTRSS CSSG+DSVFS +P+P EPCLP++P    NG +K
Sbjct: 690 PDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLK 729


>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
           [Homo sapiens]
          Length = 733

 Score =  788 bits (2035), Expect = 0.0
 Identities = 430/762 (56%), Positives = 518/762 (67%), Gaps = 85/762 (11%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTL----------------------EPEEP 38
           M SW   +   V+  ATL  ARPS +L E   L                      +P   
Sbjct: 1   MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM 60

Query: 39  PTKYQISQPE-----VYVAAPGESLEVRCLLKDAA--VISWTKDGVHLGPNNRTVLIGEY 91
           P     + PE     ++     ++++ +C         + W K+G    P++R   IG Y
Sbjct: 61  PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHR---IGGY 117

Query: 92  LQIKGAT---------PRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
            +++ AT         P D G Y C       S    + ++V +                
Sbjct: 118 -KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVE---------------- 160

Query: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEF 198
                    R+P+    +        V   + V+F C    +P P ++WLK    NG + 
Sbjct: 161 ---------RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI 211

Query: 199 KQEH-------RIGGYKVRNQHWSLI-MESVVPSDKGNYTCVVENEYGSINHTYHLDVVA 250
             ++       +  G    ++   ++ + +V   D G YTC+  N  G  +H+  L V+ 
Sbjct: 212 GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE 271

Query: 251 PGREKE-ITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKR 309
              E+  +  SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK DF SQ AVHKL K 
Sbjct: 272 ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS 331

Query: 310 IPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKL 369
           IPLRRQVTVSA+SS+SMNS   LVR  +RLSS+  TPMLAGVSEYELPEDP+WE PRD+L
Sbjct: 332 IPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPEDPRWELPRDRL 389

Query: 370 TLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMI 429
            LGKPLGEGCFGQVV+AEA+G+DKDKP     VAVKMLK DATEKDLSDL+SEMEMMKMI
Sbjct: 390 VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMI 449

Query: 430 GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFK 489
           GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ +  PEEQ++ K
Sbjct: 450 GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSK 509

Query: 490 DLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTT 549
           DLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI++IDYYKKTT
Sbjct: 510 DLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTT 569

Query: 550 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHR 609
           NGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEELFKLLKEGHR
Sbjct: 570 NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHR 629

Query: 610 MDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSP 669
           MDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+N+EYLDLS PL+QYSP
Sbjct: 630 MDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSP 689

Query: 670 SYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--INGSVK 708
           S+PDTRSS CSSG+DSVFS +P+P EPCLP++P    NG +K
Sbjct: 690 SFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLK 731


>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
           [Homo sapiens]
          Length = 820

 Score =  782 bits (2019), Expect = 0.0
 Identities = 411/664 (61%), Positives = 487/664 (73%), Gaps = 56/664 (8%)

Query: 70  ISWTKDGVHLGPNNRTVLIGEYLQIKGAT---------PRDSGLYACTASRTVDSETWYF 120
           + W K+G    P++R   IG Y +++ AT         P D G Y C       S    +
Sbjct: 186 LRWLKNGKEFKPDHR---IGGY-KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTY 241

Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
            ++V +                         R+P+    +        V   + V+F C 
Sbjct: 242 QLDVVE-------------------------RSPHRPILQAGLPANKTVALGSNVEFMCK 276

Query: 181 AGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLI-MESVVPSDKGN 228
              +P P ++WLK    NG +   ++       +  G    ++   ++ + +V   D G 
Sbjct: 277 VYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGE 336

Query: 229 YTCVVENEYGSINHTYHLDVVAPGREKE-ITASPDYLEIAIYCIGVFLIACMVVTVILCR 287
           YTC+  N  G  +H+  L V+    E+  +  SP YLEI IYC G FLI+CMV +VI+ +
Sbjct: 337 YTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYK 396

Query: 288 MKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPM 347
           MK+ TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS   LVR  +RLSS+  TPM
Sbjct: 397 MKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPM 454

Query: 348 LAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKML 407
           LAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP     VAVKML
Sbjct: 455 LAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML 514

Query: 408 KDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRAR 467
           K DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+AR
Sbjct: 515 KSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQAR 574

Query: 468 RPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV 527
           RPPG+EY Y+ +  PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NV
Sbjct: 575 RPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV 634

Query: 528 MKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTL 587
           MKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTL
Sbjct: 635 MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTL 694

Query: 588 GGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR 647
           GGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR
Sbjct: 695 GGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR 754

Query: 648 ILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--IN 704
           I+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP++P    N
Sbjct: 755 IVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLAN 814

Query: 705 GSVK 708
           G +K
Sbjct: 815 GGLK 818



 Score =  272 bits (696), Expect = 7e-73
 Identities = 138/253 (54%), Positives = 173/253 (68%), Gaps = 11/253 (4%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
           M SW   +   V+  ATL  ARPS +L E    +P   P +      E ++  PG+ L++
Sbjct: 1   MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAPVEV-----ESFLVHPGDLLQL 53

Query: 61  RCLLKD-AAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWY 119
           RC L+D    I+W +DGV L  +NRT + GE ++++ + P DSGLYAC  S    S+T Y
Sbjct: 54  RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTY 113

Query: 120 FMVNVTDAISSGDDEDDTDGAEDFVSENSNNKR---APYWTNTEKMEKRLHAVPAANTVK 176
           F VNV+DA+ S +D+DD D +     E  N K    APYWT+ EKMEK+LHAVPAA TVK
Sbjct: 114 FSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVK 173

Query: 177 FRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
           F+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR   WS+IM+SVVPSDKGNYTC+VENE
Sbjct: 174 FKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENE 233

Query: 237 YGSINHTYHLDVV 249
           YGSINHTY LDVV
Sbjct: 234 YGSINHTYQLDVV 246


>gi|105990522 fibroblast growth factor receptor 1 isoform 1
           precursor [Homo sapiens]
          Length = 822

 Score =  782 bits (2019), Expect = 0.0
 Identities = 411/664 (61%), Positives = 487/664 (73%), Gaps = 56/664 (8%)

Query: 70  ISWTKDGVHLGPNNRTVLIGEYLQIKGAT---------PRDSGLYACTASRTVDSETWYF 120
           + W K+G    P++R   IG Y +++ AT         P D G Y C       S    +
Sbjct: 188 LRWLKNGKEFKPDHR---IGGY-KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTY 243

Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
            ++V +                         R+P+    +        V   + V+F C 
Sbjct: 244 QLDVVE-------------------------RSPHRPILQAGLPANKTVALGSNVEFMCK 278

Query: 181 AGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLI-MESVVPSDKGN 228
              +P P ++WLK    NG +   ++       +  G    ++   ++ + +V   D G 
Sbjct: 279 VYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGE 338

Query: 229 YTCVVENEYGSINHTYHLDVVAPGREKE-ITASPDYLEIAIYCIGVFLIACMVVTVILCR 287
           YTC+  N  G  +H+  L V+    E+  +  SP YLEI IYC G FLI+CMV +VI+ +
Sbjct: 339 YTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYK 398

Query: 288 MKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPM 347
           MK+ TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS   LVR  +RLSS+  TPM
Sbjct: 399 MKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPM 456

Query: 348 LAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKML 407
           LAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP     VAVKML
Sbjct: 457 LAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML 516

Query: 408 KDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRAR 467
           K DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+AR
Sbjct: 517 KSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQAR 576

Query: 468 RPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV 527
           RPPG+EY Y+ +  PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NV
Sbjct: 577 RPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV 636

Query: 528 MKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTL 587
           MKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTL
Sbjct: 637 MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTL 696

Query: 588 GGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR 647
           GGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR
Sbjct: 697 GGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR 756

Query: 648 ILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--IN 704
           I+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP++P    N
Sbjct: 757 IVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLAN 816

Query: 705 GSVK 708
           G +K
Sbjct: 817 GGLK 820



 Score =  271 bits (694), Expect = 1e-72
 Identities = 138/255 (54%), Positives = 173/255 (67%), Gaps = 13/255 (5%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
           M SW   +   V+  ATL  ARPS +L E    +P   P +      E ++  PG+ L++
Sbjct: 1   MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAPVEV-----ESFLVHPGDLLQL 53

Query: 61  RCLLKD-AAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWY 119
           RC L+D    I+W +DGV L  +NRT + GE ++++ + P DSGLYAC  S    S+T Y
Sbjct: 54  RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTY 113

Query: 120 FMVNVTDAISSGDDEDDTDGAEDFVSENSNNKR-----APYWTNTEKMEKRLHAVPAANT 174
           F VNV+DA+ S +D+DD D +     E  N K      APYWT+ EKMEK+LHAVPAA T
Sbjct: 114 FSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKT 173

Query: 175 VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 234
           VKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR   WS+IM+SVVPSDKGNYTC+VE
Sbjct: 174 VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE 233

Query: 235 NEYGSINHTYHLDVV 249
           NEYGSINHTY LDVV
Sbjct: 234 NEYGSINHTYQLDVV 248


>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
           [Homo sapiens]
          Length = 806

 Score =  690 bits (1781), Expect = 0.0
 Identities = 357/536 (66%), Positives = 416/536 (77%), Gaps = 23/536 (4%)

Query: 175 VKFRCPAGGNPMPTMRWLKN-----------GKEFKQEHRIGGYKVRNQHWSLI-MESVV 222
           V+F C    +  P ++WLK+           G  +    +  G    ++   ++ + +V 
Sbjct: 271 VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVT 330

Query: 223 PSDKGNYTCVVENEYGSINHTYHLDVVAPGREKEITASPD---YLEIAIYCIGVFLIACM 279
             D G YTC+  N  G  +H+  L VV P  E+ + A      Y  I  Y +G FL   +
Sbjct: 331 FEDAGEYTCLAGNSIGFSHHSAWL-VVLPAEEELVEADEAGSVYAGILSYGVGFFLFILV 389

Query: 280 VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRL 339
           V  V LCR+++  KK      P VHK++ R PL+RQV  S ES++SM+SNTPLVRI  RL
Sbjct: 390 VAAVTLCRLRSPPKKG--LGSPTVHKIS-RFPLKRQV--SLESNASMSSNTPLVRIA-RL 443

Query: 340 SSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA 399
           SS  + P LA VSE ELP DPKWE  R +LTLGKPLGEGCFGQVVMAEA+GIDKD+  + 
Sbjct: 444 SS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKP 502

Query: 400 VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 459
           VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KGN
Sbjct: 503 VTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGN 562

Query: 460 LREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARN 519
           LRE+LRARRPPG++YS+D  + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLAARN
Sbjct: 563 LREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARN 622

Query: 520 VLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV 579
           VLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV
Sbjct: 623 VLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV 682

Query: 580 LMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFK 639
           L+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRPTFK
Sbjct: 683 LLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFK 742

Query: 640 QLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 695
           QLVEDLDR+LT+T+ +EYLDLS P EQYSP   DT SS SSGDDSVF+ D +P  P
Sbjct: 743 QLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAP 798



 Score =  212 bits (540), Expect = 8e-55
 Identities = 109/207 (52%), Positives = 138/207 (66%), Gaps = 8/207 (3%)

Query: 46  QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
           Q E  V   G+++E+ C       +    W KDG  L P+ R ++  + LQ+  A+  DS
Sbjct: 45  QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104

Query: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
           G Y+C   R       +F V VTDA SSGDDED  D AED   +      APYWT  E+M
Sbjct: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159

Query: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
           +K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219

Query: 223 PSDKGNYTCVVENEYGSINHTYHLDVV 249
           PSD+GNYTCVVEN++GSI  TY LDV+
Sbjct: 220 PSDRGNYTCVVENKFGSIRQTYTLDVL 246


>gi|13186249 fibroblast growth factor receptor 1 isoform 9 precursor
           [Homo sapiens]
          Length = 785

 Score =  683 bits (1762), Expect = 0.0
 Identities = 375/664 (56%), Positives = 450/664 (67%), Gaps = 93/664 (14%)

Query: 70  ISWTKDGVHLGPNNRTVLIGEYLQIKGAT---------PRDSGLYACTASRTVDSETWYF 120
           + W K+G    P++R   IG Y +++ AT         P D G Y C       S    +
Sbjct: 188 LRWLKNGKEFKPDHR---IGGY-KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTY 243

Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
            ++V +                         R+P+    +        V   + V+F C 
Sbjct: 244 QLDVVE-------------------------RSPHRPILQAGLPANKTVALGSNVEFMCK 278

Query: 181 AGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLI-MESVVPSDKGN 228
              +P P ++WLK    NG +   ++       +  G    ++   ++ + +V   D G 
Sbjct: 279 VYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGE 338

Query: 229 YTCVVENEYGSINHTYHLDVVAPGREKE-ITASPDYLEIAIYCIGVFLIACMVVTVILCR 287
           YTC+  N  G  +H+  L V+    E+  +  SP YLEI IYC G FLI+CMV +VI+ +
Sbjct: 339 YTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYK 398

Query: 288 MKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPM 347
           MK+ TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS   LVR  +RLSS+  TPM
Sbjct: 399 MKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPM 456

Query: 348 LAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKML 407
           LAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP     VAVKML
Sbjct: 457 LAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML 516

Query: 408 KDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRAR 467
           K DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+AR
Sbjct: 517 KSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQAR 576

Query: 468 RPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV 527
           RPPG+EY Y+ +  PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NV
Sbjct: 577 RPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV 636

Query: 528 MKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTL 587
           MKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTL
Sbjct: 637 MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTL 696

Query: 588 GGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR 647
           GGSPYPG+PVEEL                                     FKQLVEDLDR
Sbjct: 697 GGSPYPGVPVEEL-------------------------------------FKQLVEDLDR 719

Query: 648 ILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--IN 704
           I+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP++P    N
Sbjct: 720 IVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLAN 779

Query: 705 GSVK 708
           G +K
Sbjct: 780 GGLK 783



 Score =  271 bits (694), Expect = 1e-72
 Identities = 138/255 (54%), Positives = 173/255 (67%), Gaps = 13/255 (5%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
           M SW   +   V+  ATL  ARPS +L E    +P   P +      E ++  PG+ L++
Sbjct: 1   MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAPVEV-----ESFLVHPGDLLQL 53

Query: 61  RCLLKD-AAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWY 119
           RC L+D    I+W +DGV L  +NRT + GE ++++ + P DSGLYAC  S    S+T Y
Sbjct: 54  RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTY 113

Query: 120 FMVNVTDAISSGDDEDDTDGAEDFVSENSNNKR-----APYWTNTEKMEKRLHAVPAANT 174
           F VNV+DA+ S +D+DD D +     E  N K      APYWT+ EKMEK+LHAVPAA T
Sbjct: 114 FSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKT 173

Query: 175 VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 234
           VKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR   WS+IM+SVVPSDKGNYTC+VE
Sbjct: 174 VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE 233

Query: 235 NEYGSINHTYHLDVV 249
           NEYGSINHTY LDVV
Sbjct: 234 NEYGSINHTYQLDVV 248


>gi|254028242 fibroblast growth factor receptor 3 isoform 3
           precursor [Homo sapiens]
          Length = 808

 Score =  681 bits (1758), Expect = 0.0
 Identities = 357/539 (66%), Positives = 409/539 (75%), Gaps = 27/539 (5%)

Query: 175 VKFRCPAGGNPMPTMRWLK----NGKEFKQEHRIGGYKVRNQHW---------SLIMESV 221
           V+F C    +  P ++WLK    NG +   +     Y    + W          L + +V
Sbjct: 271 VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGT--PYVTVLKSWISESVEADVRLRLANV 328

Query: 222 VPSDKGNYTCVVENEYGSINHTYHLDVVAPGREKEITASPD-----YLEIAIYCIGVFLI 276
              D G Y C   N  G     + L V  P   +E     D     Y  I  Y +G FL 
Sbjct: 329 SERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFLF 388

Query: 277 ACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRIT 336
             +V  V LCR+++  KK      P VHK++ R PL+RQV  S ES++SM+SNTPLVRI 
Sbjct: 389 ILVVAAVTLCRLRSPPKKG--LGSPTVHKIS-RFPLKRQV--SLESNASMSSNTPLVRIA 443

Query: 337 TRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKP 396
            RLSS  + P LA VSE ELP DPKWE  R +LTLGKPLGEGCFGQVVMAEA+GIDKD+ 
Sbjct: 444 -RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRA 501

Query: 397 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 456
            + VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+
Sbjct: 502 AKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAA 561

Query: 457 KGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLA 516
           KGNLRE+LRARRPPG++YS+D  + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLA
Sbjct: 562 KGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA 621

Query: 517 ARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 576
           ARNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS
Sbjct: 622 ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 681

Query: 577 FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 636
           FGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRP
Sbjct: 682 FGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRP 741

Query: 637 TFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 695
           TFKQLVEDLDR+LT+T+ +EYLDLS P EQYSP   DT SS SSGDDSVF+ D +P  P
Sbjct: 742 TFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAP 800



 Score =  212 bits (540), Expect = 8e-55
 Identities = 109/207 (52%), Positives = 138/207 (66%), Gaps = 8/207 (3%)

Query: 46  QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
           Q E  V   G+++E+ C       +    W KDG  L P+ R ++  + LQ+  A+  DS
Sbjct: 45  QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104

Query: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
           G Y+C   R       +F V VTDA SSGDDED  D AED   +      APYWT  E+M
Sbjct: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159

Query: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
           +K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219

Query: 223 PSDKGNYTCVVENEYGSINHTYHLDVV 249
           PSD+GNYTCVVEN++GSI  TY LDV+
Sbjct: 220 PSDRGNYTCVVENKFGSIRQTYTLDVL 246


>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
           [Homo sapiens]
          Length = 802

 Score =  569 bits (1467), Expect = e-162
 Identities = 333/682 (48%), Positives = 421/682 (61%), Gaps = 60/682 (8%)

Query: 35  PEEPP--TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
           P++ P  T  Q  + +++    G +++ RC         I W KDG      NR   IG 
Sbjct: 143 PQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENR---IGG 199

Query: 91  Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
                    L ++   P D G Y C     V S  + ++++V +                
Sbjct: 200 IRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLE---------------- 243

Query: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEF 198
                    R+P+    +            + V+  C    +  P ++WLK    NG  F
Sbjct: 244 ---------RSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSF 294

Query: 199 KQEH--RIGGYKVRNQHWS----LIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVAPG 252
             +    +   K  + + S    L + +V   D G YTC+  N  G    +  L V+   
Sbjct: 295 GADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEE 354

Query: 253 REKEITASPD--YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRI 310
                 A+P+  Y +I +Y  G   +A +++   L R +    +      PA  +   R 
Sbjct: 355 DPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGR--HPRPPATVQKLSRF 412

Query: 311 PLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT 370
           PL RQ   S ES SS  S++ LVR   RLSS+    +LAG+   +LP DP WEFPRD+L 
Sbjct: 413 PLARQF--SLESGSSGKSSSSLVR-GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLV 468

Query: 371 LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG 430
           LGKPLGEGCFGQVV AEA G+D  +P +A TVAVKMLKD+A++KDL+DLVSEME+MK+IG
Sbjct: 469 LGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIG 528

Query: 431 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 490
           +HKNIINLLG CTQ+GPLYVIVE A+KGNLRE+LRARRPPG + S D  R  E  ++F  
Sbjct: 529 RHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPV 588

Query: 491 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN 550
           LVSC YQ+ARGM+YL S+KCIHRDLAARNVLVTE+NVMKIADFGLAR +++IDYYKKT+N
Sbjct: 589 LVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSN 648

Query: 551 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM 610
           GRLPVKWMAPEALFDRVYTHQSDVWSFG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRM
Sbjct: 649 GRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRM 708

Query: 611 DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPS 670
           D+P +C  ELY +MR+CWHA PSQRPTFKQLVE LD++L L  +EEYLDL      YSPS
Sbjct: 709 DRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPS 767

Query: 671 YPDTRSSCSSGDDSVFSPDPMP 692
             D  S+CSS  DSVFS DP+P
Sbjct: 768 GGDASSTCSS-SDSVFSHDPLP 788



 Score =  184 bits (467), Expect = 2e-46
 Identities = 100/230 (43%), Positives = 140/230 (60%), Gaps = 12/230 (5%)

Query: 24  SFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNN 83
           S    E+  LEP   P+  Q  Q +    A G+ + + C   +     W K+G  L P  
Sbjct: 21  SLEASEEVELEPCLAPSLEQ--QEQELTVALGQPVRLCCGRAERGG-HWYKEGSRLAPAG 77

Query: 84  RTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVT----DAISSGDDEDDTDG 139
           R       L+I    P D+G Y C A  ++       + N+T    D+++S +D++D   
Sbjct: 78  RVRGWRGRLEIASFLPEDAGRYLCLARGSM-----IVLQNLTLITGDSLTSSNDDEDPKS 132

Query: 140 AEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFK 199
             D  + +S  ++APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F 
Sbjct: 133 HRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFH 192

Query: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVV 249
            E+RIGG ++R+QHWSL+MESVVPSD+G YTC+VEN  GSI + Y LDV+
Sbjct: 193 GENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVL 242


>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
           [Homo sapiens]
          Length = 802

 Score =  569 bits (1467), Expect = e-162
 Identities = 333/682 (48%), Positives = 421/682 (61%), Gaps = 60/682 (8%)

Query: 35  PEEPP--TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
           P++ P  T  Q  + +++    G +++ RC         I W KDG      NR   IG 
Sbjct: 143 PQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENR---IGG 199

Query: 91  Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
                    L ++   P D G Y C     V S  + ++++V +                
Sbjct: 200 IRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLE---------------- 243

Query: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEF 198
                    R+P+    +            + V+  C    +  P ++WLK    NG  F
Sbjct: 244 ---------RSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSF 294

Query: 199 KQEH--RIGGYKVRNQHWS----LIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVAPG 252
             +    +   K  + + S    L + +V   D G YTC+  N  G    +  L V+   
Sbjct: 295 GADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEE 354

Query: 253 REKEITASPD--YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRI 310
                 A+P+  Y +I +Y  G   +A +++   L R +    +      PA  +   R 
Sbjct: 355 DPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGR--HPRPPATVQKLSRF 412

Query: 311 PLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT 370
           PL RQ   S ES SS  S++ LVR   RLSS+    +LAG+   +LP DP WEFPRD+L 
Sbjct: 413 PLARQF--SLESGSSGKSSSSLVR-GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLV 468

Query: 371 LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG 430
           LGKPLGEGCFGQVV AEA G+D  +P +A TVAVKMLKD+A++KDL+DLVSEME+MK+IG
Sbjct: 469 LGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIG 528

Query: 431 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 490
           +HKNIINLLG CTQ+GPLYVIVE A+KGNLRE+LRARRPPG + S D  R  E  ++F  
Sbjct: 529 RHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPV 588

Query: 491 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN 550
           LVSC YQ+ARGM+YL S+KCIHRDLAARNVLVTE+NVMKIADFGLAR +++IDYYKKT+N
Sbjct: 589 LVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSN 648

Query: 551 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM 610
           GRLPVKWMAPEALFDRVYTHQSDVWSFG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRM
Sbjct: 649 GRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRM 708

Query: 611 DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPS 670
           D+P +C  ELY +MR+CWHA PSQRPTFKQLVE LD++L L  +EEYLDL      YSPS
Sbjct: 709 DRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPS 767

Query: 671 YPDTRSSCSSGDDSVFSPDPMP 692
             D  S+CSS  DSVFS DP+P
Sbjct: 768 GGDASSTCSS-SDSVFSHDPLP 788



 Score =  184 bits (467), Expect = 2e-46
 Identities = 100/230 (43%), Positives = 140/230 (60%), Gaps = 12/230 (5%)

Query: 24  SFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNN 83
           S    E+  LEP   P+  Q  Q +    A G+ + + C   +     W K+G  L P  
Sbjct: 21  SLEASEEVELEPCLAPSLEQ--QEQELTVALGQPVRLCCGRAERGG-HWYKEGSRLAPAG 77

Query: 84  RTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVT----DAISSGDDEDDTDG 139
           R       L+I    P D+G Y C A  ++       + N+T    D+++S +D++D   
Sbjct: 78  RVRGWRGRLEIASFLPEDAGRYLCLARGSM-----IVLQNLTLITGDSLTSSNDDEDPKS 132

Query: 140 AEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFK 199
             D  + +S  ++APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F 
Sbjct: 133 HRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFH 192

Query: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVV 249
            E+RIGG ++R+QHWSL+MESVVPSD+G YTC+VEN  GSI + Y LDV+
Sbjct: 193 GENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVL 242


>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
           [Homo sapiens]
          Length = 762

 Score =  544 bits (1401), Expect = e-154
 Identities = 325/680 (47%), Positives = 404/680 (59%), Gaps = 96/680 (14%)

Query: 35  PEEPP--TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
           P++ P  T  Q  + +++    G +++ RC         I W KDG      NR   IG 
Sbjct: 143 PQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENR---IGG 199

Query: 91  Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
                    L ++   P D G Y C     V S  + ++++V +                
Sbjct: 200 IRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLE---------------- 243

Query: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEF 198
                    R+P+    +            + V+  C    +  P ++WLK    NG  F
Sbjct: 244 ---------RSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSF 294

Query: 199 KQEH--RIGGYKVRNQHWS----LIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVAPG 252
             +    +   K  + + S    L + +V   D G YTC+  N  G    +  L V+ PG
Sbjct: 295 GADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVL-PG 353

Query: 253 REKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPL 312
             +    + D L  A                        TK P                 
Sbjct: 354 TGRIPHLTCDSLTPA----------------------GRTKSPTLQ-------------- 377

Query: 313 RRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLG 372
                 S ES SS  S++ LVR   RLSS+    +LAG+   +LP DP WEFPRD+L LG
Sbjct: 378 -----FSLESGSSGKSSSSLVR-GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLG 430

Query: 373 KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH 432
           KPLGEGCFGQVV AEA G+D  +P +A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+H
Sbjct: 431 KPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRH 490

Query: 433 KNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 492
           KNIINLLG CTQ+GPLYVIVE A+KGNLRE+LRARRPPG + S D  R  E  ++F  LV
Sbjct: 491 KNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLV 550

Query: 493 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 552
           SC YQ+ARGM+YL S+KCIHRDLAARNVLVTE+NVMKIADFGLAR +++IDYYKKT+NGR
Sbjct: 551 SCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGR 610

Query: 553 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 612
           LPVKWMAPEALFDRVYTHQSDVWSFG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+
Sbjct: 611 LPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDR 670

Query: 613 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYP 672
           P +C  ELY +MR+CWHA PSQRPTFKQLVE LD++L L  +EEYLDL      YSPS  
Sbjct: 671 PPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGG 729

Query: 673 DTRSSCSSGDDSVFSPDPMP 692
           D  S+CSS  DSVFS DP+P
Sbjct: 730 DASSTCSS-SDSVFSHDPLP 748



 Score =  184 bits (467), Expect = 2e-46
 Identities = 100/230 (43%), Positives = 140/230 (60%), Gaps = 12/230 (5%)

Query: 24  SFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNN 83
           S    E+  LEP   P+  Q  Q +    A G+ + + C   +     W K+G  L P  
Sbjct: 21  SLEASEEVELEPCLAPSLEQ--QEQELTVALGQPVRLCCGRAERGG-HWYKEGSRLAPAG 77

Query: 84  RTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVT----DAISSGDDEDDTDG 139
           R       L+I    P D+G Y C A  ++       + N+T    D+++S +D++D   
Sbjct: 78  RVRGWRGRLEIASFLPEDAGRYLCLARGSM-----IVLQNLTLITGDSLTSSNDDEDPKS 132

Query: 140 AEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFK 199
             D  + +S  ++APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F 
Sbjct: 133 HRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFH 192

Query: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVV 249
            E+RIGG ++R+QHWSL+MESVVPSD+G YTC+VEN  GSI + Y LDV+
Sbjct: 193 GENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVL 242


>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
          Length = 1072

 Score =  329 bits (844), Expect = 5e-90
 Identities = 177/368 (48%), Positives = 233/368 (63%), Gaps = 22/368 (5%)

Query: 322  SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 374
            SS+ M    P        SS+ A  P L        V  +++ EDPKWEFPR  L LGK 
Sbjct: 670  SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729

Query: 375  LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 433
            LGEG FG+VV A A  +   K +    TVAVKMLK++A+  +L DL+SE  ++K +  H 
Sbjct: 730  LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785

Query: 434  NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 485
            ++I L GAC+QDGPL +IVEYA  G+LR +LR  R  G  Y        S  ++   E  
Sbjct: 786  HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845

Query: 486  MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 545
            +T  DL+S  +Q+++GM+YLA  K +HRDLAARN+LV E   MKI+DFGL+RD+   D Y
Sbjct: 846  LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905

Query: 546  KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 605
             K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK
Sbjct: 906  VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965

Query: 606  EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE 665
             GHRM++P NC+ E+Y +M  CW   P +RP F  + +DL+++  +    +YLDL+    
Sbjct: 966  TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLAASTP 1023

Query: 666  QYSPSYPD 673
              S  Y D
Sbjct: 1024 SDSLIYDD 1031


>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
          Length = 1114

 Score =  329 bits (844), Expect = 5e-90
 Identities = 177/368 (48%), Positives = 233/368 (63%), Gaps = 22/368 (5%)

Query: 322  SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 374
            SS+ M    P        SS+ A  P L        V  +++ EDPKWEFPR  L LGK 
Sbjct: 670  SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729

Query: 375  LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 433
            LGEG FG+VV A A  +   K +    TVAVKMLK++A+  +L DL+SE  ++K +  H 
Sbjct: 730  LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785

Query: 434  NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 485
            ++I L GAC+QDGPL +IVEYA  G+LR +LR  R  G  Y        S  ++   E  
Sbjct: 786  HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845

Query: 486  MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 545
            +T  DL+S  +Q+++GM+YLA  K +HRDLAARN+LV E   MKI+DFGL+RD+   D Y
Sbjct: 846  LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905

Query: 546  KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 605
             K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK
Sbjct: 906  VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965

Query: 606  EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE 665
             GHRM++P NC+ E+Y +M  CW   P +RP F  + +DL+++  +    +YLDL+    
Sbjct: 966  TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLAASTP 1023

Query: 666  QYSPSYPD 673
              S  Y D
Sbjct: 1024 SDSLIYDD 1031


>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [Homo
            sapiens]
          Length = 1338

 Score =  322 bits (826), Expect = 6e-88
 Identities = 218/625 (34%), Positives = 309/625 (49%), Gaps = 134/625 (21%)

Query: 92   LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNK 151
            L I   + +DSG YAC A      E       +T                        ++
Sbjct: 621  LTIMNVSLQDSGTYACRARNVYTGEEILQKKEIT----------------------IRDQ 658

Query: 152  RAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRN 211
             APY           H V  +++    C A G P P + W KN  + +QE    G  +  
Sbjct: 659  EAPYLLRNLSD----HTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEP---GIILGP 711

Query: 212  QHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVAPGREKEITASPDYLEIAIYCI 271
               +L +E V   D+G Y C   N+ GS+  + +L V     +  +    + + +   C+
Sbjct: 712  GSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNL----ELITLTCTCV 767

Query: 272  GVFLIACMVVTVILCRMKNTTK--KPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSN 329
               L   +++T+ + +MK ++   K D+ S   +      +PL  Q              
Sbjct: 768  AATLF-WLLLTLFIRKMKRSSSEIKTDYLS---IIMDPDEVPLDEQCE------------ 811

Query: 330  TPLVRITTRLSSTADTPMLAGVSEYELPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEA 388
                                      LP D  KWEF R++L LGK LG G FG+VV A A
Sbjct: 812  -------------------------RLPYDASKWEFARERLKLGKSLGRGAFGKVVQASA 846

Query: 389  VGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QDGP 447
             GI K       TVAVKMLK+ AT  +   L++E++++  IG H N++NLLGACT Q GP
Sbjct: 847  FGIKKSPTCR--TVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGP 904

Query: 448  LYVIVEYASKGNLREYLRARRP--------------------PGMEYSY----------- 476
            L VIVEY   GNL  YL+++R                     PG+E              
Sbjct: 905  LMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSE 964

Query: 477  -----------DINRVPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLA 516
                        ++ V EE+         +T +DL+S ++Q+ARGME+L+S+KCIHRDLA
Sbjct: 965  SFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLA 1024

Query: 517  ARNVLVTENNVMKIADFGLARDI-NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 575
            ARN+L++ENNV+KI DFGLARDI  N DY +K    RLP+KWMAPE++FD++Y+ +SDVW
Sbjct: 1025 ARNILLSENNVVKICDFGLARDIYKNPDYVRKGDT-RLPLKWMAPESIFDKIYSTKSDVW 1083

Query: 576  SFGVLMWEIFTLGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 634
            S+GVL+WEIF+LGGSPYPG+ ++E F   L+EG RM  P   T E+Y +M DCWH  P +
Sbjct: 1084 SYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKE 1143

Query: 635  RPTFKQLVEDLDRILTLTTNEEYLD 659
            RP F +LVE L  +L     ++  D
Sbjct: 1144 RPRFAELVEKLGDLLQANVQQDGKD 1168



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 30/120 (25%), Positives = 53/120 (44%), Gaps = 11/120 (9%)

Query: 157 TNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
           T   + ++ L  V    + +        P P + WLK+G       +   Y  R   +SL
Sbjct: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG--LPATEKSARYLTRG--YSL 390

Query: 217 IMESVVPSDKGNYTCVV----ENEYGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIG 272
           I++ V   D GNYT ++     N + ++  T  ++V     EK +++ PD    A+Y +G
Sbjct: 391 IIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPD---PALYPLG 447


>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
          Length = 1356

 Score =  318 bits (816), Expect = 8e-87
 Identities = 221/591 (37%), Positives = 303/591 (51%), Gaps = 116/591 (19%)

Query: 157  TNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
            T T  +E +  ++    +++  C A GNP P + W K+ +   ++    G  +++ + +L
Sbjct: 668  TITGNLENQTTSI--GESIEVSCTASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNL 722

Query: 217  IMESVVPSDKGNYTCVVENEYGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLI 276
             +  V   D+G YTC   +  G         ++   +EK        LEI I  +G  +I
Sbjct: 723  TIRRVRKEDEGLYTCQACSVLGCAKVEAFF-IIEGAQEKT------NLEIIIL-VGTAVI 774

Query: 277  ACM--VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR 334
            A    ++ VI+ R                             TV   +   +        
Sbjct: 775  AMFFWLLLVIILR-----------------------------TVKRANGGELK------- 798

Query: 335  ITTRLSSTADTPMLAGVSEYE-LPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGID 392
             T  LS   D   L      E LP D  KWEFPRD+L LGKPLG G FGQV+ A+A GID
Sbjct: 799  -TGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGID 857

Query: 393  KDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG-PLYVI 451
            K       TVAVKMLK+ AT  +   L+SE++++  IG H N++NLLGACT+ G PL VI
Sbjct: 858  KTATCR--TVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVI 915

Query: 452  VEYASKGNLREYLRARRPPGMEYS-----------------YDINR-------------- 480
            VE+   GNL  YLR++R   + Y                   D+ R              
Sbjct: 916  VEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASS 975

Query: 481  ----------VPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVL 521
                      V EE+         +T + L+  ++Q+A+GME+LAS+KCIHRDLAARN+L
Sbjct: 976  GFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNIL 1035

Query: 522  VTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLM 581
            ++E NV+KI DFGLARDI     Y +  + RLP+KWMAPE +FDRVYT QSDVWSFGVL+
Sbjct: 1036 LSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLL 1095

Query: 582  WEIFTLGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ 640
            WEIF+LG SPYPG+ ++E F + LKEG RM  P   T E+Y  M DCWH  PSQRPTF +
Sbjct: 1096 WEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSE 1155

Query: 641  LVEDLDRILTLTTNEE-----YLDLSQPL---EQYSPSYPDTRSSCSSGDD 683
            LVE L  +L     ++      L +S+ L   E    S P +  SC   ++
Sbjct: 1156 LVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEE 1206



 Score = 38.5 bits (88), Expect = 0.022
 Identities = 43/160 (26%), Positives = 61/160 (38%), Gaps = 37/160 (23%)

Query: 92  LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNK 151
           L I G T  D GLY C AS  + ++     V V +              + FV+  S   
Sbjct: 292 LTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHE--------------KPFVAFGSG-- 335

Query: 152 RAPYWTNTEKMEKRLHAVPAANTVKFRCPAG--GNPMPTMRWLKNGKEFKQEHRIGGYKV 209
                     ME  + A       + R PA   G P P ++W KNG   +  H I     
Sbjct: 336 ----------MESLVEATVGE---RVRIPAKYLGYPPPEIKWYKNGIPLESNHTI----- 377

Query: 210 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVV 249
           +  H   IME V   D GNYT ++ N       ++ + +V
Sbjct: 378 KAGHVLTIME-VSERDTGNYTVILTNPISKEKQSHVVSLV 416



 Score = 30.0 bits (66), Expect = 7.7
 Identities = 16/55 (29%), Positives = 27/55 (49%), Gaps = 1/55 (1%)

Query: 70  ISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNV 124
           I W K+G+ L  +N T+  G  L I   + RD+G Y    +  +  E    +V++
Sbjct: 362 IKWYKNGIPL-ESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSL 415


>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
           homolog isoform 2 precursor [Homo sapiens]
          Length = 972

 Score =  289 bits (739), Expect = 7e-78
 Identities = 164/403 (40%), Positives = 229/403 (56%), Gaps = 70/403 (17%)

Query: 355 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 414
           +LP D KWEFPR++L+ GK LG G FG+VV A A G+ K     A+TVAVKMLK  A   
Sbjct: 571 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 628

Query: 415 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 469
           +   L+SE++++  +G H NI+NLLGACT  GP  VI EY   G+L  +LR +R      
Sbjct: 629 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 688

Query: 470 ---------------------------------PGMEY----------SYDINRVPEEQM 486
                                            PG+ Y          S  I    E  +
Sbjct: 689 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 748

Query: 487 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 534
           T             +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T   + KI DFG
Sbjct: 749 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 808

Query: 535 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 594
           LARDI N   Y    N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 809 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 868

Query: 595 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 653
           +PV+ + +K++KEG RM  P +   E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 869 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 928

Query: 654 NEEYLDLS-------QPLEQYSPSYPDTRSSCSSGDDSVFSPD 689
           N  Y +L+       +P+  +S       S+ SS    +   D
Sbjct: 929 NHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDD 971


>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
           homolog isoform 1 precursor [Homo sapiens]
          Length = 976

 Score =  289 bits (739), Expect = 7e-78
 Identities = 164/403 (40%), Positives = 229/403 (56%), Gaps = 70/403 (17%)

Query: 355 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 414
           +LP D KWEFPR++L+ GK LG G FG+VV A A G+ K     A+TVAVKMLK  A   
Sbjct: 575 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 632

Query: 415 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 469
           +   L+SE++++  +G H NI+NLLGACT  GP  VI EY   G+L  +LR +R      
Sbjct: 633 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 692

Query: 470 ---------------------------------PGMEY----------SYDINRVPEEQM 486
                                            PG+ Y          S  I    E  +
Sbjct: 693 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 752

Query: 487 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 534
           T             +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T   + KI DFG
Sbjct: 753 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 812

Query: 535 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 594
           LARDI N   Y    N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 813 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 872

Query: 595 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 653
           +PV+ + +K++KEG RM  P +   E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 873 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 932

Query: 654 NEEYLDLS-------QPLEQYSPSYPDTRSSCSSGDDSVFSPD 689
           N  Y +L+       +P+  +S       S+ SS    +   D
Sbjct: 933 NHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDD 975


>gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like
            domains 1 [Homo sapiens]
          Length = 1138

 Score =  244 bits (624), Expect = 2e-64
 Identities = 134/295 (45%), Positives = 186/295 (63%), Gaps = 10/295 (3%)

Query: 367  DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 426
            + +T    +GEG FGQV+ A    I KD  K  +  A+KMLK+ A+E D  D   E+E++
Sbjct: 837  EDITFEDLIGEGNFGQVIRAM---IKKDGLK--MNAAIKMLKEYASENDHRDFAGELEVL 891

Query: 427  KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 486
              +G H NIINLLGAC   G LY+ +EYA  GNL ++LR  R    + ++         +
Sbjct: 892  CKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTL 951

Query: 487  TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYK 546
            + + L+      A GM+YL+ ++ IHRDLAARNVLV EN   KIADFGL+R     + Y 
Sbjct: 952  SSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYV 1008

Query: 547  KTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKE 606
            K T GRLPV+WMA E+L   VYT +SDVWSFGVL+WEI +LGG+PY G+   EL++ L +
Sbjct: 1009 KKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQ 1068

Query: 607  GHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLS 661
            G+RM++P NC +E+Y +MR CW   P +RP F Q+   L R+  L   + Y+++S
Sbjct: 1069 GYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRM--LEARKAYVNMS 1121


>gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens]
          Length = 1124

 Score =  244 bits (623), Expect = 2e-64
 Identities = 128/275 (46%), Positives = 182/275 (66%), Gaps = 8/275 (2%)

Query: 375  LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 434
            +GEG FGQV+ A    I KD  +  +  A+K +K+ A++ D  D   E+E++  +G H N
Sbjct: 830  IGEGNFGQVLKAR---IKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884

Query: 435  IINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSC 494
            IINLLGAC   G LY+ +EYA  GNL ++LR  R    + ++ I       ++ + L+  
Sbjct: 885  IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944

Query: 495  TYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP 554
               +ARGM+YL+ ++ IHRDLAARN+LV EN V KIADFGL+R     + Y K T GRLP
Sbjct: 945  AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLP 1001

Query: 555  VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 614
            V+WMA E+L   VYT  SDVWS+GVL+WEI +LGG+PY G+   EL++ L +G+R++KP 
Sbjct: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061

Query: 615  NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 649
            NC +E+Y +MR CW   P +RP+F Q++  L+R+L
Sbjct: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096


>gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor
           [Homo sapiens]
          Length = 940

 Score =  230 bits (587), Expect = 3e-60
 Identities = 171/637 (26%), Positives = 287/637 (45%), Gaps = 71/637 (11%)

Query: 46  QPEVYVAAPGESLEVRCL----LKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRD 101
           +P V+ A  G    V CL    L + +V  W   GV L  + R    G  L +      D
Sbjct: 329 EPRVFTA--GSEERVTCLPPKGLPEPSVW-WEHAGVRLPTHGRVYQKGHELVLANIAESD 385

Query: 102 SGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDT-----------DGAEDFVSENSNN 150
           +G+Y C A+           + V +  S  +   D            D A ++    SN 
Sbjct: 386 AGVYTCHAANLAGQRRQDVNITVANGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNG 445

Query: 151 KRAPYWTNTE---------KMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQE 201
            +     + +         K+E     V   +T   +C A G+P P ++W K        
Sbjct: 446 PQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDP 504

Query: 202 HRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT----YHLDVVAPGREKEI 257
            ++G      Q+ SL++  V P D G YTC+  N   +I HT    Y +D   P   +  
Sbjct: 505 TKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSC-NIKHTEAPLYVVDKPVPEESEGP 563

Query: 258 TASPDYLEIAIYCIGVFLIACMVVTVI--------LCRMKNTTKKPDFSSQPAVHKLTKR 309
            + P Y  I    + V      ++ V+         C+ K   K+P+   +P +  L   
Sbjct: 564 GSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGG 622

Query: 310 IPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKL 369
                Q +   +   ++ S       T +  ST+D                K  FPR  L
Sbjct: 623 PLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD----------------KMHFPRSSL 666

Query: 370 TLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMI 429
                LG+  FG+V +A+A G+++   +  V V     KD+  + D      E+EM   +
Sbjct: 667 QPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMFGKL 723

Query: 430 GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFK 489
             H N++ LLG C +  P Y+++EY   G+L+++LR  +           ++  + ++ K
Sbjct: 724 N-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD-------EKLKSQPLSTK 775

Query: 490 DLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTT 549
             V+   Q+A GME+L++ + +H+DLAARN LV+    +K++  GL++D+ N +YY    
Sbjct: 776 QKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FR 834

Query: 550 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH- 608
              +P++WM+PEA+ +  ++ +SDVW+FGVLMWE+FT G  P+ G   +E+   L+ G  
Sbjct: 835 QAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKA 894

Query: 609 RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 645
           R+ +P  C ++LY +M+ CW   P  RP+F ++   L
Sbjct: 895 RLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 931



 Score = 38.5 bits (88), Expect = 0.022
 Identities = 43/202 (21%), Positives = 66/202 (32%), Gaps = 36/202 (17%)

Query: 44  ISQPEVYVAAPGESLEVRCLLKDAAVIS--WTKDGVHLGPNNRTVLIGEYLQIKGATP-R 100
           I QP    A  G    +RC ++    +   W  DG  +    R    G  L        +
Sbjct: 35  IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ 94

Query: 101 DSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTE 160
           DSG + C A                         DD  G E   +  S N +   W    
Sbjct: 95  DSGTFQCVA------------------------RDDVTGEEARSANASFNIK---WIEAG 127

Query: 161 KMEKRLHAVPAA----NTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
            +  +  A  A       V  RC   G+P PT +W ++G           + V ++  +L
Sbjct: 128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNL 185

Query: 217 IMESVVPSDKGNYTCVVENEYG 238
            +    P   G Y+C   + +G
Sbjct: 186 TLRPAGPEHSGLYSCCAHSAFG 207



 Score = 34.7 bits (78), Expect = 0.31
 Identities = 58/251 (23%), Positives = 91/251 (36%), Gaps = 67/251 (26%)

Query: 41  KYQISQPEVYVAAPGESLEVRCLLKD--AAVISWTKDGVHL--GPNNRTVLIGEY-LQIK 95
           K+  S+ E+    P   + +RC +         W +DG  L  G +N TV   E  L ++
Sbjct: 132 KHPASEAEIQ---PQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLR 188

Query: 96  GATPRDSGLYACTASRTVDS--ETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 153
            A P  SGLY+C A         +  F +++ D              E F    +    A
Sbjct: 189 PAGPEHSGLYSCCAHSAFGQACSSQNFTLSIAD--------------ESF----ARVVLA 230

Query: 154 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 213
           P      + E+ +          F C     P P+++WL     F+ E  I   + R  H
Sbjct: 231 PQDVVVARYEEAM----------FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPH 274

Query: 214 ---------WSLIMESVVPSDKGNYTCVVENEYGS---INHTYHL-----------DVVA 250
                     SL++  V P + G Y C+ + + G    +  T HL            V  
Sbjct: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFT 334

Query: 251 PGREKEITASP 261
            G E+ +T  P
Sbjct: 335 AGSEERVTCLP 345


>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
            sapiens]
          Length = 1367

 Score =  228 bits (580), Expect = 2e-59
 Identities = 115/285 (40%), Positives = 176/285 (61%), Gaps = 9/285 (3%)

Query: 361  KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLV 420
            +WE  R+K+T+ + LG+G FG V    A G+ KD+P+    VA+K + + A+ ++  + +
Sbjct: 991  EWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPE--TRVAIKTVNEAASMRERIEFL 1048

Query: 421  SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINR 480
            +E  +MK    H +++ LLG  +Q  P  VI+E  ++G+L+ YLR+ RP  ME     N 
Sbjct: 1049 NEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPE-ME-----NN 1101

Query: 481  VPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDIN 540
                  +   ++    ++A GM YL + K +HRDLAARN +V E+  +KI DFG+ RDI 
Sbjct: 1102 PVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY 1161

Query: 541  NIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEEL 600
              DYY+K   G LPV+WM+PE+L D V+T  SDVWSFGV++WEI TL   PY G+  E++
Sbjct: 1162 ETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQV 1221

Query: 601  FKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 645
             + + EG  +DKP NC + L+ +MR CW   P  RP+F +++  +
Sbjct: 1222 LRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSI 1266


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,179,869
Number of Sequences: 37866
Number of extensions: 1363969
Number of successful extensions: 8736
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 669
Number of HSP's successfully gapped in prelim test: 333
Number of HSP's that attempted gapping in prelim test: 4110
Number of HSP's gapped (non-prelim): 2839
length of query: 709
length of database: 18,247,518
effective HSP length: 109
effective length of query: 600
effective length of database: 14,120,124
effective search space: 8472074400
effective search space used: 8472074400
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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