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Search of human proteins with 22208850
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22208850 Golgi coiled-coil protein 1 [Homo sapiens]
(775 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22208850 Golgi coiled-coil protein 1 [Homo sapiens] 1487 0.0
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 107 3e-23
gi|4504063 golgin 97 [Homo sapiens] 105 1e-22
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 105 2e-22
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 100 9e-21
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 100 9e-21
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 100 9e-21
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 100 9e-21
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 100 9e-21
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 100 9e-21
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 100 9e-21
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 100 9e-21
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 97 4e-20
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 96 1e-19
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 96 1e-19
gi|148746195 trichohyalin [Homo sapiens] 95 2e-19
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 94 4e-19
gi|21735548 centrosomal protein 2 [Homo sapiens] 93 1e-18
gi|16262452 cingulin [Homo sapiens] 91 3e-18
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 91 5e-18
gi|55770834 centromere protein F [Homo sapiens] 91 5e-18
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 91 5e-18
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 89 2e-17
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 89 2e-17
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 89 2e-17
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 89 2e-17
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 89 2e-17
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 89 2e-17
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 89 2e-17
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 89 2e-17
>gi|22208850 Golgi coiled-coil protein 1 [Homo sapiens]
Length = 775
Score = 1487 bits (3850), Expect = 0.0
Identities = 775/775 (100%), Positives = 775/775 (100%)
Query: 1 MEKFGMNFGGGPSKKDLLETIETQKKQLLQYQARLKDVVRAYKSLLKEKEALEASIKVLS 60
MEKFGMNFGGGPSKKDLLETIETQKKQLLQYQARLKDVVRAYKSLLKEKEALEASIKVLS
Sbjct: 1 MEKFGMNFGGGPSKKDLLETIETQKKQLLQYQARLKDVVRAYKSLLKEKEALEASIKVLS 60
Query: 61 VSHEADVGLAGVQLPGLTFPDSVDDRCSTHSEDSTGTATSLDTAASLTSTKGEFGVEDDR 120
VSHEADVGLAGVQLPGLTFPDSVDDRCSTHSEDSTGTATSLDTAASLTSTKGEFGVEDDR
Sbjct: 61 VSHEADVGLAGVQLPGLTFPDSVDDRCSTHSEDSTGTATSLDTAASLTSTKGEFGVEDDR 120
Query: 121 PARGPPPPKSEEASWSESGVSSSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKS 180
PARGPPPPKSEEASWSESGVSSSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKS
Sbjct: 121 PARGPPPPKSEEASWSESGVSSSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKS 180
Query: 181 RMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHDRAQEQ 240
RMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHDRAQEQ
Sbjct: 181 RMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHDRAQEQ 240
Query: 241 SDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVE 300
SDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVE
Sbjct: 241 SDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVE 300
Query: 301 ELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEE 360
ELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEE
Sbjct: 301 ELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEE 360
Query: 361 QRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDS 420
QRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDS
Sbjct: 361 QRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDS 420
Query: 421 HGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALY 480
HGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALY
Sbjct: 421 HGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALY 480
Query: 481 YQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEE 540
YQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEE
Sbjct: 481 YQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEE 540
Query: 541 LEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKD 600
LEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKD
Sbjct: 541 LEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKD 600
Query: 601 LELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQL 660
LELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQL
Sbjct: 601 LELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQL 660
Query: 661 ARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQSREGANL 720
ARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQSREGANL
Sbjct: 661 ARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQSREGANL 720
Query: 721 EYLKNIIYRFLTLPDSLGRQQTLTAILTILHFSPEEKQVIMRLPTSASWWPSGKR 775
EYLKNIIYRFLTLPDSLGRQQTLTAILTILHFSPEEKQVIMRLPTSASWWPSGKR
Sbjct: 721 EYLKNIIYRFLTLPDSLGRQQTLTAILTILHFSPEEKQVIMRLPTSASWWPSGKR 775
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 107 bits (268), Expect = 3e-23
Identities = 154/710 (21%), Positives = 282/710 (39%), Gaps = 143/710 (20%)
Query: 156 KRLHQLKTQLATLTSSLATVTQEKSRMEASY------LADKKKMKQDLEDASNKAEEERA 209
K L + + T+ L ++ EK ++ AS K + + E S + + E+
Sbjct: 979 KELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKE 1038
Query: 210 R---LEGELKGLQEQIAETKARLITQQHD------RAQEQSDHALMLRELQKLLQEERTQ 260
R E ++ L Q+ + + T D R + +A +L E+Q L +
Sbjct: 1039 RANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLL-EVQILEVQRAKA 1097
Query: 261 RQDLELRLEETR--EALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDP 318
D EL E+ + + + A ++E ++Q ++ +++++ EL+ ++ + Q
Sbjct: 1098 MVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTL 1157
Query: 319 RLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLG 378
E+ + +K +L Q++ + L Q+ ++++Q+ L+ +I+ + +
Sbjct: 1158 MNMEIADYERLMK-----ELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQ 1212
Query: 379 TYEKAKQK-DQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESS---LDVNVLKD 434
YE+ K QL ++ KE E L L AS + L++ ++ + + +
Sbjct: 1213 QYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITS 1272
Query: 435 KMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFER 494
+ K+ L+ +A + Q TL + + AA E+AT + EFE
Sbjct: 1273 EKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQAT----------VTSEFES 1322
Query: 495 YKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQ 554
YK+R VLK + K + E E A+++ L+ L++ ++ ++ Q
Sbjct: 1323 YKVRVHNVLKQQKNKSMSQA-ETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVS---- 1377
Query: 555 ELARLQQLHRQELER-------------------CQLD---------------------- 573
EL LQ H LER C +
Sbjct: 1378 ELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNE 1437
Query: 574 -----FRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGG--- 625
FRD+ L+EE K + L++ + +L QL++ P RSPV
Sbjct: 1438 VLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNE------PTTRSPVSSQQSL 1491
Query: 626 -----------------------GPG----DPADTSSSDSLTQALQLAAANEPTFF---L 655
G G D SS+ + TQ+L+ + T L
Sbjct: 1492 KNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPL 1551
Query: 656 YAEQLARKEV--EITSLRKQKHRLEVEVHQLQDRLLEEGERHR----EEVAALQSHIEKN 709
+ + ++E+ +++S K L + LL E E E++ L+S I +
Sbjct: 1552 WHAEFTKEELVQKLSSTTKSADHL--------NGLLRETEATNAILMEQIKLLKSEIRRL 1603
Query: 710 IRDQSRE--GANLEYLKNIIYRFLTLPDSLGRQQTLTAILTILHFSPEEK 757
R+Q RE ANLEYLKN++ +F+ L R++ L I T+L SPEEK
Sbjct: 1604 ERNQEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEK 1653
Score = 69.7 bits (169), Expect = 1e-11
Identities = 122/623 (19%), Positives = 261/623 (41%), Gaps = 77/623 (12%)
Query: 151 GGEV--DKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEER 208
G EV D + L + SLA + +EK + ++ D+K + +LE +EE
Sbjct: 767 GSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNL--AFQRDEKVL--ELEKEIKCLQEES 822
Query: 209 ARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRL 268
ELK L + K L + + E+ L E++ ++ R + Q+L +++
Sbjct: 823 VVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQV 882
Query: 269 EETREALAGRAYAAEQMEGFELQTKQL-----TREVEELKSELQAIRDE-------KNQP 316
EE + + E+ + F + + L +E+ + ++EL ++D KN P
Sbjct: 883 EEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDP 942
Query: 317 DPRLQELQEEAARLKSHFQAQLQQEMRKTALAE-------DQLRQQSQVEEQRVAALENQ 369
++EL+E+ L+ + + ++++ K L D R+++Q ++ + +L ++
Sbjct: 943 LSSVKELEEKIENLEKECK-EKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSE 1001
Query: 370 ISEVS--------------ELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSR 415
++S LL YE KQ +QL ++K + + +E+ T L S+
Sbjct: 1002 KDQLSASMRDLIQGAESYKNLLLEYE--KQSEQLDVEKERANNFEHRIEDLTRQLRNSTL 1059
Query: 416 --SPLDSHGEESSLDVNVLKDKMEKLK-RLLQVAARKSQV--TLDVEKL-CDLEIMPSSE 469
++S E+ + L+ + L+ ++L+V K+ V L+ EKL + +I +
Sbjct: 1060 QCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHAT 1119
Query: 470 AADGEKATALYYQQELKQLKE-----------------------EFERYKMRAQVVLKSK 506
+ + + Q+E KQL++ ++ER L +K
Sbjct: 1120 TVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNK 1179
Query: 507 NTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQH---QQEADDWKQELARLQQLH 563
N K +L +E++ +++ L+E+ SL+ S ++ E ++ +Q K+ELA +Q
Sbjct: 1180 NNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAE 1239
Query: 564 RQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVA--LASGLPGRRSP 621
L Q + ++++ + + + +EK E L++ A L +
Sbjct: 1240 TDHL-ILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQR 1298
Query: 622 VGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEV 681
V A + ++T + + + + E ++++ LE+ +
Sbjct: 1299 VTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLI 1358
Query: 682 HQLQDRLLEEGERHREEVAALQS 704
QL+ +L + + V+ LQ+
Sbjct: 1359 DQLKIKLQDSQNNLQINVSELQT 1381
Score = 66.2 bits (160), Expect = 1e-10
Identities = 113/563 (20%), Positives = 236/563 (41%), Gaps = 68/563 (12%)
Query: 152 GEVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARL 211
GE +K L Q +L + QEK+ + L+ + M ++LE N EE+
Sbjct: 542 GENEKLLSQ--QELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDF 599
Query: 212 EGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEE- 270
+LK E+ + H + + + ++ EL K +++ +LE ++ E
Sbjct: 600 INKLKNSHEE--------MDNFHKKCEREE---RLILELGKKVEQTIQYNSELEQKVNEL 648
Query: 271 ---TREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQEL---- 323
E L + +++E +Q K L+ + E L +E++++ +E N+ ++L
Sbjct: 649 TGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDL 708
Query: 324 -----QEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLG 378
Q+E LK H QL+++++ +D L + + E+ + ++ Q+ + +G
Sbjct: 709 EVFLSQKEDVILKEHI-TQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMG 767
Query: 379 T--YEKAKQKDQL-AIQKLKERILQLDLENKTLALAASSR-----SPLDSHGEESSLDVN 430
+ E +++KD + +Q + E + +++ E LA + + EES +
Sbjct: 768 SEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCE 827
Query: 431 VLKDKM---EKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQ 487
LK + E+ K LL+ + Q + + LE+ ++E E L +E+ Q
Sbjct: 828 ELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQ 887
Query: 488 LKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQ 547
+ E + + + +K NL LE Q++L + + + I L+ S +
Sbjct: 888 TCSKSEIHNEKEKCFIKEHE----NLKPLLE--QKELRDRRAELILLKDSLAKSPSVKND 941
Query: 548 EADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLR 607
K+ +++ L ++ E+ EE+++K + +AV +K+L+ +
Sbjct: 942 PLSSVKELEEKIENLEKECKEK------------EEKINK--IKLVAVKAKKELDSSRKE 987
Query: 608 SVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEI 667
+ + L RS S S+ +Q A + + Y +Q + +VE
Sbjct: 988 TQTVKEELESLRS----------EKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEK 1037
Query: 668 TSLRKQKHRLEVEVHQLQDRLLE 690
+HR+E QL++ L+
Sbjct: 1038 ERANNFEHRIEDLTRQLRNSTLQ 1060
Score = 65.9 bits (159), Expect = 1e-10
Identities = 116/576 (20%), Positives = 241/576 (41%), Gaps = 66/576 (11%)
Query: 170 SSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQEQ-IAETKAR 228
+S AT KS++E D K + KA+ LE E++ L+ + + E
Sbjct: 10 ASPATPGTGKSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGD 69
Query: 229 LITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGF 288
+I +R AL+L + + Q ++++++++ +E +++ A +++E
Sbjct: 70 IIKALTERLD-----ALLLEKAETEQQCLSLKKENIKMK-QEVEDSVTKMGDAHKELEQS 123
Query: 289 ELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALA 348
+ +E+E LK+EL A+R + ++ LQ+ EEA + Q +L ++++ +
Sbjct: 124 HIN---YVKEIENLKNELMAVRSKYSEDKANLQKQLEEA----MNTQLELSEQLKFQNNS 176
Query: 349 EDQLRQ-QSQVE------EQRVAALENQI--------SEVSELLGTYEKAKQKDQLAIQK 393
ED +++ Q ++E E+++ L+ Q+ V++L E Q Q I
Sbjct: 177 EDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINS 236
Query: 394 LKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKSQVT 453
L+E +LQL ++ + +++ +E ++N L + E L + + + + Q
Sbjct: 237 LQEELLQLKAIHQEEVKELMCQ--IEASAKEHEAEINKLNELKENLVKQCEASEKNIQKK 294
Query: 454 LDVEKLCDLEIMPSSEAADGEKATALYYQ---------QELKQLKEEFERYKMRAQVVLK 504
+ E L +L S+ D + + L + +++K L++ + + + +LK
Sbjct: 295 YECE-LENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQ-HSILK 352
Query: 505 SKNTKDGNLGKELEA-AQEQLAELKEKYISLRLSCEELEHQHQQEA---DDWKQELARLQ 560
+ T NL +LE AQ E + L EL +++ + K ELA L
Sbjct: 353 DEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLN 412
Query: 561 QLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRS 620
+ +E+ + + L +Q + ++ L E L + + L + G +
Sbjct: 413 KQFCYTVEQHNREV--------QSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKE 464
Query: 621 PVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVE 680
+ +SL + +++ E + E S+++Q+ +
Sbjct: 465 QCENLQQEKQEAILNYESLREIMEILQTE------LGESAGKISQEFESMKQQQ---ASD 515
Query: 681 VHQLQDRL---LEEGERHREEVAALQSHIEKNIRDQ 713
VH+LQ +L E + E V LQ EK + Q
Sbjct: 516 VHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQ 551
Score = 57.8 bits (138), Expect = 4e-08
Identities = 94/478 (19%), Positives = 207/478 (43%), Gaps = 77/478 (16%)
Query: 158 LHQLKTQLATLTSSLA-TVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELK 216
+ +LK++LA L TV Q +++ +K++ + E + +E+E+ L E++
Sbjct: 401 IEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQ 460
Query: 217 GLQEQ----------------------------IAETKARLITQQHDRAQEQSDHALMLR 248
GL+EQ + E+ ++ + Q+Q+ +
Sbjct: 461 GLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASD---VH 517
Query: 249 ELQKLLQEERTQRQDL---ELRLEETREALAGRAYAAEQMEG-----------FELQTKQ 294
ELQ+ L+ T++ L RL+ E L + ++E + L Q
Sbjct: 518 ELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQ 577
Query: 295 LTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQ 354
++EL+ ++ ++ +EK+ +L+ EE +F + ++E R ++ Q
Sbjct: 578 RDTMLKELEGKINSLTEEKDDFINKLKNSHEE----MDNFHKKCEREERLILELGKKVEQ 633
Query: 355 QSQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLD-LENKTLALAAS 413
Q + LE +++E++ G E K+KDQ QKL++ ++Q+ L L+A
Sbjct: 634 TIQYNSE----LEQKVNELTG--GLEETLKEKDQ-NDQKLEKLMVQMKVLSEDKEVLSAE 686
Query: 414 SRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADG 473
+S + + N L + ++L R L+V + + + E + LE +
Sbjct: 687 VKSLYEEN--------NKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQ 738
Query: 474 EKATALYYQQELKQLKEEFERY----KMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKE 529
+ L +++++L + + Y +M ++V S+++++ ++ L+A E LA++ E
Sbjct: 739 DNLNKLLENEQVQKLFVKTQLYGFLKEMGSEV---SEDSEEKDVVNVLQAVGESLAKINE 795
Query: 530 KYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHK 587
+ +L +E + ++E ++E + +EL+ D+ + L +EL +
Sbjct: 796 EKCNLAFQRDEKVLELEKEIKCLQEE----SVVQCEELKSLLRDYEQEKVLLRKELEE 849
>gi|4504063 golgin 97 [Homo sapiens]
Length = 767
Score = 105 bits (263), Expect = 1e-22
Identities = 164/791 (20%), Positives = 320/791 (40%), Gaps = 120/791 (15%)
Query: 10 GGPSKKDLLETIETQKKQLLQYQARLKDVVRAYKSLLKEKEALEASIKVLSVSHEADVGL 69
G S++DL + + +Q+ + +ARL D ++L K KE LE +++ H+ D +
Sbjct: 49 GSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALE----KHQ-DSSM 103
Query: 70 AGVQLPGLTFPDSVDDRCSTHSEDSTGTATSLDTAASLTSTKGEFGVEDDRPARGPPPPK 129
Q TF + ++ + G A +L
Sbjct: 104 RKFQEQNETFQ-------ANRAKMAEGLALAL---------------------------A 129
Query: 130 SEEASWSESGVSSSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLAD 189
++ WSE +++K + L QL + + + Q + M+
Sbjct: 130 RKDQEWSEKM------------DQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQ 177
Query: 190 KKKMKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRE 249
++++ + ++ K EE ++E EL+ +++ T+ L+ Q SD + L E
Sbjct: 178 QQELSK-IKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSN----QMSSDLSQKLEE 232
Query: 250 LQKLLQEERTQRQDLELRLEETRE-ALAGRAYAAEQMEGFELQTKQLTREVEELKSELQA 308
LQ+ LEE R+ +A + A ++ E + ++L +++L +LQ
Sbjct: 233 LQRHYST-----------LEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQK 281
Query: 309 IRDEKNQPDPRLQELQEEAARLKSHFQAQL------QQEMRKTALAEDQL---RQQ---- 355
+ E + + + LQE+ A L+ + L Q+ +++ LAE L RQQ
Sbjct: 282 VTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAA 341
Query: 356 SQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSR 415
+ + + LE ++ E+ + L E+ Q+ + + + +I +L N+ +
Sbjct: 342 RSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQA 401
Query: 416 SPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEK 475
L+ E + + +E+ + Q A + L+ E E + +
Sbjct: 402 LALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAA------LKECRNEYE 455
Query: 476 ATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAEL----KEKY 531
+ +Q ELK+LKEE+ + ++ + + ++ + K+ E Q+Q A L EK
Sbjct: 456 RSLQNHQFELKKLKEEWSQREIVSVAMAQALE----EVRKQREEFQQQAANLTAIIDEKE 511
Query: 532 ISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDR 591
+LR E L + Q+ + + L Q+H+ + E L RTLK EE
Sbjct: 512 QNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEAL----RTLKAEE-------- 559
Query: 592 ALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEP 651
AV+ E++ +L +LR A L S V DP + T ++ A +
Sbjct: 560 -AAVVAEQE-DLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLT 617
Query: 652 TFFLYAEQLARKEVEITSLRKQKHRLEVEVHQL---------QDRLLEEGERHREEVAAL 702
+ L ++ +E KQ + +E+ + + L E E+ E+A +
Sbjct: 618 QLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKELKIRPDNELFEVREKPGPEMANM 677
Query: 703 QSHIEKNIRDQSREGANLEYLKNIIYRFLTLPDSLGRQQTLTAILTILHFSPEEKQVIMR 762
+ N N EYLK+++ +F++ +S + A+ +L+FS EE+ ++
Sbjct: 678 APSVTNNTDLTDAREINFEYLKHVVLKFMSCRES-EAFHLIKAVSVLLNFSQEEENMLKE 736
Query: 763 -LPTSASWWPS 772
L SW+ S
Sbjct: 737 TLEYKMSWFGS 747
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 105 bits (262), Expect = 2e-22
Identities = 170/791 (21%), Positives = 333/791 (42%), Gaps = 124/791 (15%)
Query: 13 SKKDLLETIETQKKQLLQYQARLKDVVRAYKSLLKEKEALEASIKVLSVSHEADVGLAGV 72
+K+ L++ + ++ L Y+ + ++V AY+ L +EK+ L+ +LS S + +
Sbjct: 135 NKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQG---ILSQSQDKSLR---- 187
Query: 73 QLPGLTFPDSVDDRCSTHSEDSTGTA--------TSLDTAASLTSTKGEFGVEDDRPARG 124
++ L +D + H ++ + + L T SL + G + +
Sbjct: 188 RIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKP 247
Query: 125 PPPPKSEEASWSESGVSSSSGDGPFAGGEVDKRLHQL---------------------KT 163
P + + +++ S G+ G K L L K
Sbjct: 248 LPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKE 307
Query: 164 QLATLTS-------SLATVTQEKSRMEASYLADKKKMKQDLEDASN---KAEEERARLEG 213
Q LTS L QE +++ ++A+K K+ L DA N + E+++ +
Sbjct: 308 QCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIA 367
Query: 214 ELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRL----- 268
E K + E K I Q R ++ + LRE ++ + ER ++LE L
Sbjct: 368 ETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKE--KSERAAFEELEKALSTAQK 425
Query: 269 -EETREALAGRAYAAEQMEGFELQTKQ----LTREVEELKSE-LQAIRDEKNQPDPRLQE 322
EE R L +A EQ++ E +++ L +E+ +K E + ++ + +LQ+
Sbjct: 426 TEEARRKL--KAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQK 483
Query: 323 LQE-EAARLKSHFQAQLQ------QEMRKTALAEDQ---LRQQSQVEEQRVAALENQISE 372
L E E AR + +LQ QE K AL + Q L+ + E+Q ALE +
Sbjct: 484 LHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQ 543
Query: 373 VSELLGTYEKAKQKDQLAIQKLKERILQLDL---------ENKTLALAASSRSPLDSHGE 423
+L E + Q + + RIL+L+ +N++ LA + + H +
Sbjct: 544 KKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNK 603
Query: 424 ESSLDVNVLKDKMEKLKR------LLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKAT 477
E ++ V K ++E LK ++ K Q ++EKL E + EK T
Sbjct: 604 EITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKL--------REKCEQEKET 655
Query: 478 AL-----YYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYI 532
L +Q ++++ E+ Q L+S +++ + K +E+L+ LK++
Sbjct: 656 LLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTD 715
Query: 533 SLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRA 592
++ +ELE + ++ + +Q++ + + H ++R + +D+ +L E L K+RD+
Sbjct: 716 KMK---QELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQL-ELLLKERDKH 771
Query: 593 LAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPT 652
L E +E L + S G+ S+ + Q+ Q +A +E T
Sbjct: 772 ---LKEHQAHVENLEADIKRS-------------EGELQQASAKLDVFQSYQ-SATHEQT 814
Query: 653 FFLYAEQLARKEVEITSLRKQKHRLEVEVHQLQDR---LLEEGERHREEVAALQSHIEKN 709
Y EQLA+ + ++ L ++ L +V +++ + + E + H+ +V L +EK
Sbjct: 815 -KAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQ 873
Query: 710 IRDQSREGANL 720
+ ++ +L
Sbjct: 874 NSEMEQKVKSL 884
Score = 92.0 bits (227), Expect = 2e-18
Identities = 153/794 (19%), Positives = 336/794 (42%), Gaps = 104/794 (13%)
Query: 13 SKKDLLETIETQKKQLLQYQARLKDVVRAYKSLLKEKE-----ALEASIKVLSVSHEADV 67
+K+ + ET+E +++++ Q ++R+K + + L ++KE A E K LS + + +
Sbjct: 369 TKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEE 428
Query: 68 GLAGVQLPGLTFPDSVDDRCSTHSEDSTGTATSLDTAASLTSTKGEFGVEDDRPARGPPP 127
++ +D++ T + S SL L+ K E V+ + +
Sbjct: 429 ARRKLKA-------EMDEQIKTIEKTSEEERISLQQ--ELSRVKQEV-VDVMKKSSEEQI 478
Query: 128 PKSEEASWSESGVSSSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYL 187
K ++ E E + + Q+K L S ++QEK + E+ L
Sbjct: 479 AKLQKLHEKELARKEQELTKKLQTREREFQ-EQMKVALEKSQSEYLKISQEKEQQESLAL 537
Query: 188 ADKKKMKQ--------DLEDASNKAEEERAR---LEGEL-KGLQEQIAETK--------- 226
+ + K+ L D +AE R R LE L K LQE ++K
Sbjct: 538 EELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAE 597
Query: 227 -------ARLITQQHDRAQEQSDH---ALMLRELQKLLQEERTQRQDLELRLEETREALA 276
++ ++H E H AL +LQ L Q+ +T+ + L + E+ +E L
Sbjct: 598 KNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLL 657
Query: 277 GRAYAAEQMEGFELQTKQLTR------EVEELKSELQAIRDEKNQPDPRLQELQEEAARL 330
Q E+ K L + E+E L SEL + +++ + L L+++ ++
Sbjct: 658 KDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKM 717
Query: 331 KSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRV-AALENQISEVSELLGTYEKAKQKDQL 389
K +A++ ++ D + ++ +V QR AL++QI+++ LL +K ++ Q
Sbjct: 718 KQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQA 777
Query: 390 AIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKL---------- 439
++ L+ I + + E L A++ S+ + ++++ +L
Sbjct: 778 HVENLEADIKRSEGE---LQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETE 834
Query: 440 -----KRLLQVAARKSQV--TLDVEKLCDLEIMPSSEAADGE-----KATALYYQQELKQ 487
K++ +V A+K V LD K+ ++M E + E K+ Y+ +L+
Sbjct: 835 RILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLED 894
Query: 488 LKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQ 547
+E E+ K Q++++ +N + + E ++++ L +K + S L +++
Sbjct: 895 GNKEQEQTK---QILVEKENM----ILQMREGQKKEIEILTQKLSAKEDSIHILNEEYET 947
Query: 548 EADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHK---QRDRALAVLTEKDLELE 604
+ + ++++ +++Q ++ E + D+ KL++EL + + K LE+
Sbjct: 948 KFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMA 1007
Query: 605 QLRSVALASGL----PGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQL 660
Q S ++ + ++ + + + S+ + +L E ++ QL
Sbjct: 1008 QANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEK-KLNQQAEELQEIHEIQL 1066
Query: 661 ARKEVEITSLRK-------QKHRLEVEVHQLQDRLLEEG---ERHREEVAALQSHIEKNI 710
KE E+ L++ +K + E+ L++ +++ +E++ +H+
Sbjct: 1067 QEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLA 1126
Query: 711 RDQSREGANLEYLK 724
+D+++ A+LE L+
Sbjct: 1127 QDETKLKAHLEKLE 1140
Score = 78.6 bits (192), Expect = 2e-14
Identities = 140/683 (20%), Positives = 274/683 (40%), Gaps = 114/683 (16%)
Query: 151 GGEVDKRLHQLKTQLATLTSSLATVTQE----KSRMEASYLADKKKMKQDLEDASNKAEE 206
G E D R+ + + ++ TL + + ++ E K +E L+ K K +++L+ ++ E
Sbjct: 1573 GEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSK-EEELKALEDRLES 1631
Query: 207 ERARLEGELKGLQEQ-IAETKARLITQQHDRAQE-QSDHALMLRELQKLLQEERTQRQDL 264
E A ELK EQ IA K +L++Q ++ ++ + L EL LQE + L
Sbjct: 1632 ESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHIL 1691
Query: 265 ELRLEETREALAGRAYAAEQMEGFELQTKQ--------LTREVEELKSELQAIRDEKNQP 316
E +L+ + + + T+Q + + EE S LQ EK +
Sbjct: 1692 EEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKL 1751
Query: 317 DPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSEL 376
R+ + +EE + SHF+ + Q + R L + +Q ++ + L+ ++ E ++
Sbjct: 1752 LQRVGQEKEET--VSSHFEMRCQYQERLIKLEHAEAKQHE--DQSMIGHLQEELEEKNKK 1807
Query: 377 LGTY-----EKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNV 431
EK K+ + ++ E + D KTL +E L +
Sbjct: 1808 YSLIVAQHVEKEGGKNNIQAKQNLENVF--DDVQKTL--------------QEKELTCQI 1851
Query: 432 LKDKMEKLKRLLQVAARKSQVTLDVEKLCD-LEIMPSSEAADGE-KATALYYQQELKQLK 489
L+ K+++L L +K +++E+L E + + + DG K T L L++
Sbjct: 1852 LEQKIKELDSCL--VRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTEL-----LEENT 1904
Query: 490 EEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEA 549
EE + + +L + + +L +L A+ + +L ++ + L+ L +HQQE
Sbjct: 1905 EEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQEL 1964
Query: 550 D------------DWKQELARLQQLHRQELERCQLDFRDRTLKLEEEL------------ 585
+ KQE L+ H L++ +F + + E+EL
Sbjct: 1965 EILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQ 2024
Query: 586 ----------HKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPADTSS 635
++ ++ L + EKD +L+ R+ + R D
Sbjct: 2025 EVEAELLESHQEETNQLLKKIAEKDDDLK--RTAKRYEEILDAREEEMTAKVRDLQTQLE 2082
Query: 636 SDSLTQALQLAAANEP-----TFFLYAEQLARKEVEITSLRKQKHRLEVEVHQLQDRLLE 690
+L P T QLA+K I+ + ++ ++H L+DRL
Sbjct: 2083 ELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRL-- 2140
Query: 691 EGERHREEVAALQ----------SHIEKNIRDQSREGANLEYLKNIIYRFLTLPDSLGRQ 740
+++ + V A H + ++ + E EYL+ +++ ++ +GR+
Sbjct: 2141 --KKYEKNVYATTVGTPYKGGNLYHTDVSLFGEPTE---FEYLRKVLFEYM-----MGRE 2190
Query: 741 QTLTA--ILTILHFSPEEKQVIM 761
A I T+L F ++ Q I+
Sbjct: 2191 TKTMAKVITTVLKFPDDQTQKIL 2213
Score = 71.2 bits (173), Expect = 3e-12
Identities = 146/659 (22%), Positives = 266/659 (40%), Gaps = 129/659 (19%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLE 212
E++ +L QL + TL S T + E K MK D+E S E+E + E
Sbjct: 1273 ELEAQLRQLTEEQNTLNISFQQATHQLEEKENQI----KSMKADIE--SLVTEKEALQKE 1326
Query: 213 GELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERT----QRQDLELRL 268
G G Q+Q A K ITQ E + +++E K + E + Q DL ++L
Sbjct: 1327 G---GNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQL 1383
Query: 269 EETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEK----NQPDPRLQELQ 324
+ + A + + ++ + +L +V++L ++ + EK Q D +
Sbjct: 1384 QNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFS 1443
Query: 325 EEAARLKSHF--------QAQLQQEMRKTA---------LAEDQLRQQSQVEEQRVAALE 367
E + +S F + Q+Q E++ L +++L QQ++ + +E
Sbjct: 1444 EWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEME 1503
Query: 368 NQISEVSELLGTYEKAKQKDQLAIQKLKERILQL------------------DLENKTLA 409
+ S++ + E + I +L++ I Q D+E+K L
Sbjct: 1504 DDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELV 1563
Query: 410 LAASSRSPL----DSHGEESSLDVNVLKDKMEKLKRLLQVAARKSQ-VTLDV----EKLC 460
L D+ +E+ + L++++ +K L+ ++ + V L V E+L
Sbjct: 1564 QKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELK 1623
Query: 461 DLEIMPSSEAA--------DGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGN 512
LE SE+A E+ A +Q L Q++E+ E+YK + L NTK
Sbjct: 1624 ALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQE 1683
Query: 513 LGKELEAAQEQLAELK----EKYISLRLSCEELEHQHQQEADD-------WKQELARLQQ 561
+E+ +E+L ++ E I R + + Q+EAD ++++++ LQ+
Sbjct: 1684 REREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQR 1743
Query: 562 --------LHR--QELE---------RCQLDFRDRTLKLEE-ELHKQRDRALAVLTEKDL 601
L R QE E RCQ +++R +KLE E + D+++ +++L
Sbjct: 1744 NLTEKEKLLQRVGQEKEETVSSHFEMRCQ--YQERLIKLEHAEAKQHEDQSMIGHLQEEL 1801
Query: 602 ELEQLR-SVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQL 660
E + + S+ +A + GG + +Q E F + L
Sbjct: 1802 EEKNKKYSLIVAQHVEKE------GGKNN-------------IQAKQNLENVFDDVQKTL 1842
Query: 661 ARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQSREGAN 719
KE+ LE ++ +L L+ + E HR E+ L S EK Q +G N
Sbjct: 1843 QEKELTC-------QILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRN 1894
Score = 69.3 bits (168), Expect = 1e-11
Identities = 121/578 (20%), Positives = 245/578 (42%), Gaps = 63/578 (10%)
Query: 155 DKRLHQLKTQLATLTSSLATVTQEKSRMEAS---YLADKKKMKQDLEDASNKAEEERARL 211
+++L QL+ +L L + +T++ + +EA + K ++D + E++ + +
Sbjct: 818 EEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEM 877
Query: 212 EGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEET 271
E ++K L Q+ E+K + ++ QEQ+ L+ +E +LQ Q++++E+ ++
Sbjct: 878 EQKVKSLT-QVYESKL----EDGNKEQEQTKQILVEKE-NMILQMREGQKKEIEILTQKL 931
Query: 272 REALAGRAYAAEQMEG-FELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARL 330
E+ E F+ Q K++ + ++ K + ++ + + +L++ E A
Sbjct: 932 SAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALE 991
Query: 331 KSHFQAQLQQEMRKTALAEDQ------LRQQSQVEEQRVAALENQISEVSELLGTYEKAK 384
S + Q +M + A A R ++ +EQ + E E+++++ +EK
Sbjct: 992 LSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKL 1051
Query: 385 QKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDK--------M 436
+ +Q++ E +QL + + +A EE + ++ LK++
Sbjct: 1052 NQQAEELQEIHE--IQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLN 1109
Query: 437 EKLKRLLQVAARKSQVTLDVEKL-CDLEIMPSSEAADGEKATALYYQQ-ELKQLKEEFER 494
E ++L Q +A + + D KL LE + ++ T L Q ELK L EE +R
Sbjct: 1110 ELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKR 1169
Query: 495 YKMRAQVVLKSKNTKDGNL-------GKELEAAQEQLAELKEKY-ISLRLSCEELEHQHQ 546
LK+ + + +L K LE + +L E+ I L + C++ E +
Sbjct: 1170 KVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLE 1229
Query: 547 QEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELH------KQRDRALAVLTEKD 600
+ ++ + + CQ RT K++E L + + L LTE+
Sbjct: 1230 AKTNELINISSSKTNAILSRISHCQ----HRTTKVKEALLIKTCTVSELEAQLRQLTEEQ 1285
Query: 601 LELE---------------QLRSVA--LASGLPGRRSPVGGGGPGDPADTSSSDSLTQAL 643
L Q++S+ + S + + + GG A + +TQ
Sbjct: 1286 NTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLK 1345
Query: 644 QLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEV 681
+ + N L E+L K+VEI+SL KQ L V++
Sbjct: 1346 KELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQL 1383
Score = 60.1 bits (144), Expect = 8e-09
Identities = 123/578 (21%), Positives = 241/578 (41%), Gaps = 107/578 (18%)
Query: 21 IETQKKQLLQYQARLKDVVRAYKSLLKEKEALEASIKVLSVSHEADVGLAGVQLPGLTFP 80
+ET+KK+L +K K+L E+ E++ K+ + +A+ +A ++ L+
Sbjct: 1601 LETKKKELEHVNLSVKSKEEELKALEDRLES-ESAAKLAELKRKAEQKIAAIKKQLLS-- 1657
Query: 81 DSVDDRCSTHSEDSTGTATSLDTAASLTSTKGEFGVEDDRPARGPPPPKSEEASWSESGV 140
++++ + + + + L+T L + E + +++ KS E+S SE+ +
Sbjct: 1658 -QMEEKEEQYKKGTESHLSELNT--KLQEREREVHILEEKL-------KSVESSQSETLI 1707
Query: 141 SSSSGDGPFAGGE-------------VDKRLHQLKTQLATLTSSLATVTQEKSRMEASYL 187
S A E ++++ L+ L L V QEK +S+
Sbjct: 1708 VPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHF 1767
Query: 188 ADKKKMKQ---DLEDASNKAEEERARLEGELKGLQEQIAET--KARLITQQH-------D 235
+ + ++ LE A K E+++ + LQE++ E K LI QH +
Sbjct: 1768 EMRCQYQERLIKLEHAEAKQHEDQSMIGH----LQEELEEKNKKYSLIVAQHVEKEGGKN 1823
Query: 236 RAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQL 295
Q + + + ++QK LQE+ Q LE +++E L Q E ++ ++L
Sbjct: 1824 NIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLV------RQKEVHRVEMEEL 1877
Query: 296 TREVEELKSELQAIRDEKNQPDPRLQELQEEAAR-------LKSHFQAQLQQEMRKTALA 348
T + E+L++ Q D +N+P L+E EE ++ L S+ +AQ K A A
Sbjct: 1878 TSKYEKLQALQQM--DGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGA 1935
Query: 349 EDQ--------------LRQQSQVEEQRVAALENQISEVSELLGTYEKAKQ-------KD 387
E + LR + +Q + L+ + + E EK KQ K
Sbjct: 1936 EREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQERE-----EKIKQEQEDLELKH 1990
Query: 388 QLAIQKL----------KERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKME 437
+++L KE+ L++ ++ L+SH EE++ + + +K +
Sbjct: 1991 NSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDD 2050
Query: 438 KLKRLLQ-----VAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEF 492
LKR + + AR+ ++T V L ++ + +K +QE +
Sbjct: 2051 DLKRTAKRYEEILDAREEEMTAKVRDL-------QTQLEELQKKYQQKLEQEENPGNDNV 2103
Query: 493 ERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEK 530
+++ Q+ K+ D L KE E +EQ+ L+++
Sbjct: 2104 TIMELQTQLAQKTTLISDSKL-KEQE-FREQIHNLEDR 2139
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 99.8 bits (247), Expect = 9e-21
Identities = 138/593 (23%), Positives = 257/593 (43%), Gaps = 63/593 (10%)
Query: 154 VDKRLHQLKTQLATLTSSLATVT-------QEKSRMEASYLADKKKMKQDLEDASNKAEE 206
VD R H ++L TLTS +E+ R+ A++++ ++E A K +
Sbjct: 1317 VDLRTHY--SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1374
Query: 207 -------ERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERT 259
+A+ E E K LQ+++ E R D Q++ R +Q+ LQ+ R
Sbjct: 1375 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-------RSIQEELQQLRQ 1427
Query: 260 QRQ-DLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDP 318
+ +++ + + A R E++ LQ + R+ + ELQA+R + +
Sbjct: 1428 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1487
Query: 319 RLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLG 378
+ ++ QEEA RL+ Q+Q E ++ AE +L + + E + + + + EL
Sbjct: 1488 QKRQAQEEAERLR----RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1543
Query: 379 TYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEK 438
E+A+++ + A + + R +Q+ LE + A +S S E+++ L+++
Sbjct: 1544 QAEEAERRLRQA-EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1602
Query: 439 LKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLK-EEFERYKM 497
+ +L + A R++Q + E+ + E A+ E E QLK E R ++
Sbjct: 1603 VAQLREEAERRAQQQAEAER--------AREEAERE--------LERWQLKANEALRLRL 1646
Query: 498 RAQVVLKSKNTKDGNLGKELEAAQEQL---AELKEKYISLR-LSCEELEHQHQQEADDWK 553
+A+ V + K+ K+ E A+ + + +E+ + R L+ +ELE Q Q +
Sbjct: 1647 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1706
Query: 554 QELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALAS 613
Q LA Q+L R E Q + + R L EE QR+ A A ++LE E + A
Sbjct: 1707 QRLAAEQELIRLRAETEQGE-QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1765
Query: 614 GLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQ 673
L + + S+S+ Q L+ A F AE+ AR ++Q
Sbjct: 1766 VL------LASKARAEEESRSTSEKSKQRLEAEAGR---FRELAEEAARLRALAEEAKRQ 1816
Query: 674 KHRLEVEVHQLQ---DRLLEEGERHREEVAALQSHIEKNIRDQSREGANLEYL 723
+ E + + + +R+L E E L++ E ++++ E L L
Sbjct: 1817 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1869
Score = 96.7 bits (239), Expect = 7e-20
Identities = 136/608 (22%), Positives = 258/608 (42%), Gaps = 91/608 (14%)
Query: 177 QEKSRMEASYLADKKKMKQDLEDASN---KAEEERARLEGELKGLQEQIAETKARLITQQ 233
+E +R + L + +++K +E+A +AE+E AR +L+ L ++ A+ + + +
Sbjct: 1998 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR---QLQ-LAQEAAQKRLQAEEKA 2053
Query: 234 HDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTK 293
H A +Q + +ELQ+ LQ+E++ L E R A A Q E Q++
Sbjct: 2054 HAFAVQQKE-----QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2108
Query: 294 QLTREVEELK----SELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQ------EMR 343
+ E E LK + QA + + +E ++EAAR QA L+Q EM
Sbjct: 2109 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2168
Query: 344 K-TALAEDQLRQQSQVEEQRVAALENQISEVSELLG------------TYEKAKQKDQLA 390
K AE LRQ++QV EQ + L Q+ E E A+Q+ Q+
Sbjct: 2169 KHKKFAEQTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2227
Query: 391 IQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKS 450
+ R+ +L + A +R+ + + + L+++ EK+K++ + AAR S
Sbjct: 2228 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ---RFLQEEAEKMKQVAEEAARLS 2284
Query: 451 QVTLDVEKLCDL-----------------EIMPSSEAADGEKATALYYQQELKQLKEEFE 493
+ +L L E M + + A KA A QQ+ + +E+
Sbjct: 2285 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2344
Query: 494 RYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEEL---EHQHQQEAD 550
R + + + + + + LEA +++ E+ + L+L E+ + + +++A
Sbjct: 2345 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2404
Query: 551 DWKQELARL-QQLHRQELERCQLDFRDRTLKLE-EELHKQRDRALAVLTEKDLELEQLRS 608
++++ + ++LHR EL + +TL+++ ++ +R + E + E E+L+
Sbjct: 2405 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2464
Query: 609 VALASGLPGRRSPVGGGGPGDPADTSSSDSL---TQALQLAAANEPTFFLYAEQLARKE- 664
A L + T + L TQALQ + +E L E+ +E
Sbjct: 2465 EAKLLQL-----------KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2513
Query: 665 -----------VEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQ 713
+ LR+++ R + ++ Q + RL+ EE Q E+ +R +
Sbjct: 2514 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS----MEEARRRQHEAEEGVRRK 2569
Query: 714 SREGANLE 721
E LE
Sbjct: 2570 QEELQQLE 2577
Score = 85.9 bits (211), Expect = 1e-16
Identities = 149/651 (22%), Positives = 273/651 (41%), Gaps = 94/651 (14%)
Query: 156 KRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEE---ERARLE 212
++ +L+ +LA + + + + K+R E + +K KQ LE + + E E ARL
Sbjct: 1748 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1807
Query: 213 G--ELKGLQEQIAETKA--------RLITQ------QHDRAQEQSDHALMLRE-----LQ 251
E Q Q+AE A R++ + + R + +++ AL +E L+
Sbjct: 1808 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1867
Query: 252 KLLQEERTQRQ-----------DLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVE 300
+L ++E QR+ D+E RL + R+A E+ +G T + R+VE
Sbjct: 1868 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL---ERQKGLVEDTLRQRRQVE 1924
Query: 301 E----LKSELQAIRDEKNQPDPRLQELQEEAA-RLKSHFQAQLQ---------QEMRKTA 346
E LK+ + K + + L ++ A L+S QA+L+ +E R+
Sbjct: 1925 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1984
Query: 347 LAEDQLRQQSQVEE----QRVAAL---ENQISEVSELLGTYEKAKQKDQLAIQKLKERI- 398
AE+++++ EE QR AAL E ++V E E+A+Q+ +Q +E
Sbjct: 1985 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2044
Query: 399 LQLDLENKTLALAASSR-SPLDSHGEESSLDVNVLKDKMEKLKRL--------LQVAARK 449
+L E K A A + L ++ ++ L+ + E +R +Q
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2104
Query: 450 SQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTK 509
+Q VE+ L+ + E A ++ K+ ++E R Q L+ K
Sbjct: 2105 AQSRRQVEEAERLK-QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2163
Query: 510 DGNLGKELEAAQE---QLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQE 566
D + K + A++ Q A+++++ +LRL EE +HQ ++ ++ A + RQ
Sbjct: 2164 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ- 2222
Query: 567 LERCQLDFRDRTLKLE-EELHKQRDRALA-----VLTEKD-------LELEQLRSVALAS 613
R Q++ +++++ EEL K + R A +L +KD E E+++ VA +
Sbjct: 2223 --RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA 2280
Query: 614 GLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQ 673
R V + D L Q LA ++ R + E L++Q
Sbjct: 2281 A----RLSVAAQEAARLRQLAEED-LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2335
Query: 674 KHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQSREGANLEYLK 724
K + + +LQ+ + ++ EE Q +E + Q A E LK
Sbjct: 2336 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2386
Score = 85.1 bits (209), Expect = 2e-16
Identities = 127/568 (22%), Positives = 233/568 (41%), Gaps = 86/568 (15%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAE---EERA 209
+V++ L ++ Q+ L+ A + E A L DK ++ L++ + K + EE A
Sbjct: 2225 QVEEELFSVRVQMEELSKLKARIEAEN---RALILRDKDNTQRFLQEEAEKMKQVAEEAA 2281
Query: 210 RLEGELKGLQEQIAETKARLITQ--QHDRAQEQSDHALMLRELQKLLQEERTQRQDLELR 267
RL +A +A + Q + D AQ+++ ML+E + +QE + + EL
Sbjct: 2282 RLS---------VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL- 2331
Query: 268 LEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEA 327
L++ +E + A E E +QL E + + L+A R R E+ EA
Sbjct: 2332 LQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ-------RQLEMSAEA 2382
Query: 328 ARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEE--QRVAALENQISEVSELLGTYEKAKQ 385
RLK + + R ED R + Q EE +++ E E L+ T E +Q
Sbjct: 2383 ERLKLRVAEMSRAQAR---AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2439
Query: 386 KDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQV 445
+ ++L+E I +L+ E K+K+++ +LLQ+
Sbjct: 2440 QSDHDAERLREAIAELERE----------------------------KEKLQQEAKLLQL 2471
Query: 446 AARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKS 505
+ + Q + L + + + S ++ + L Q + E+ K + + + +
Sbjct: 2472 KSEEMQTVQQEQLLQETQALQQSFLSE---------KDSLLQRERFIEQEKAKLEQLFQD 2522
Query: 506 KNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQ 565
+ K L +E + Q+Q+ + +++ ++ +H+ ++ ++EL +L+Q RQ
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2582
Query: 566 ELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGG 625
+ E + +L E+L ++ A L E VA LP R +
Sbjct: 2583 QEEL----LAEENQRLREQLQLLEEQHRAALAHS--EEVTASQVAATKTLPNGRDAL--D 2634
Query: 626 GPGDPADTSSS-DSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQL 684
GP A+ S D L + + E L AE+L R T++ + R +V H L
Sbjct: 2635 GPAAEAEPEHSFDGLRRKVSAQRLQE-AGILSAEELQRLAQGHTTVDELARREDVR-HYL 2692
Query: 685 QDR------LLEEGERHREEVAALQSHI 706
Q R LL+ AALQ +
Sbjct: 2693 QGRSSIAGLLLKATNEKLSVYAALQRQL 2720
Score = 37.4 bits (85), Expect = 0.053
Identities = 112/475 (23%), Positives = 193/475 (40%), Gaps = 72/475 (15%)
Query: 253 LLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKS-ELQAIRD 311
L+ + Q+ RLE +AL + L + L R+V+ ++S L R
Sbjct: 857 LVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRT 916
Query: 312 EKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALA-EDQLRQQSQVEEQRVAALENQI 370
K P+ + Q L L+ H+QA L+ ED+L + E+ + +
Sbjct: 917 LK--PEEQRQALHS----LELHYQAFLRDSQDAGGFGPEDRL-----MAEREYGSCSHHY 965
Query: 371 SEVSELLGTYEKAKQKDQLAIQKLKERILQLDL-ENKTLALAASSRSPLDSH-GEESSLD 428
++ + L + + + Q I +LK+ LQL+ E +T+ R PLD E +
Sbjct: 966 QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL---RLPLDKEPARECAQR 1022
Query: 429 VNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDL-EIMPSSEAADGEKATALYYQQELKQ 487
+ + +++ L + AR S + EK+ L E P++ E L ++++
Sbjct: 1023 IAEQQKAQAEVEGLGKGVARLSA---EAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1079
Query: 488 LKEEF-ERYKMRAQVVLKSKNTKDGNLG-----KELEAAQEQLAELKEKYISLRLSCEEL 541
L + E+ K + V+ ++ ++ KE +A L EL+ SL+ +
Sbjct: 1080 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1139
Query: 542 EHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLE---EELHKQRDRALAVLTE 598
E Q Q D + EL Q++ ER Q +R +++E E + + +R AVL +
Sbjct: 1140 EAQ-QPTFDALRDELRGAQEVG----ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1194
Query: 599 KDL---ELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFL 655
D+ ELEQL GR+ S+D L LQ A + +
Sbjct: 1195 TDVRQRELEQL----------GRQLRYY---------RESADPLGAWLQDARRRQEQ--I 1233
Query: 656 YAEQLARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNI 710
A LA + LR+++ LLEE ERH E+V Q ++ I
Sbjct: 1234 QAMPLADSQAVREQLRQEQ------------ALLEEIERHGEKVEECQRFAKQYI 1276
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 99.8 bits (247), Expect = 9e-21
Identities = 138/593 (23%), Positives = 257/593 (43%), Gaps = 63/593 (10%)
Query: 154 VDKRLHQLKTQLATLTSSLATVT-------QEKSRMEASYLADKKKMKQDLEDASNKAEE 206
VD R H ++L TLTS +E+ R+ A++++ ++E A K +
Sbjct: 1321 VDLRTHY--SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1378
Query: 207 -------ERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERT 259
+A+ E E K LQ+++ E R D Q++ R +Q+ LQ+ R
Sbjct: 1379 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-------RSIQEELQQLRQ 1431
Query: 260 QRQ-DLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDP 318
+ +++ + + A R E++ LQ + R+ + ELQA+R + +
Sbjct: 1432 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1491
Query: 319 RLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLG 378
+ ++ QEEA RL+ Q+Q E ++ AE +L + + E + + + + EL
Sbjct: 1492 QKRQAQEEAERLR----RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1547
Query: 379 TYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEK 438
E+A+++ + A + + R +Q+ LE + A +S S E+++ L+++
Sbjct: 1548 QAEEAERRLRQA-EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1606
Query: 439 LKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLK-EEFERYKM 497
+ +L + A R++Q + E+ + E A+ E E QLK E R ++
Sbjct: 1607 VAQLREEAERRAQQQAEAER--------AREEAERE--------LERWQLKANEALRLRL 1650
Query: 498 RAQVVLKSKNTKDGNLGKELEAAQEQL---AELKEKYISLR-LSCEELEHQHQQEADDWK 553
+A+ V + K+ K+ E A+ + + +E+ + R L+ +ELE Q Q +
Sbjct: 1651 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1710
Query: 554 QELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALAS 613
Q LA Q+L R E Q + + R L EE QR+ A A ++LE E + A
Sbjct: 1711 QRLAAEQELIRLRAETEQGE-QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1769
Query: 614 GLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQ 673
L + + S+S+ Q L+ A F AE+ AR ++Q
Sbjct: 1770 VL------LASKARAEEESRSTSEKSKQRLEAEAGR---FRELAEEAARLRALAEEAKRQ 1820
Query: 674 KHRLEVEVHQLQ---DRLLEEGERHREEVAALQSHIEKNIRDQSREGANLEYL 723
+ E + + + +R+L E E L++ E ++++ E L L
Sbjct: 1821 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1873
Score = 96.7 bits (239), Expect = 7e-20
Identities = 136/608 (22%), Positives = 258/608 (42%), Gaps = 91/608 (14%)
Query: 177 QEKSRMEASYLADKKKMKQDLEDASN---KAEEERARLEGELKGLQEQIAETKARLITQQ 233
+E +R + L + +++K +E+A +AE+E AR +L+ L ++ A+ + + +
Sbjct: 2002 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR---QLQ-LAQEAAQKRLQAEEKA 2057
Query: 234 HDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTK 293
H A +Q + +ELQ+ LQ+E++ L E R A A Q E Q++
Sbjct: 2058 HAFAVQQKE-----QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2112
Query: 294 QLTREVEELK----SELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQ------EMR 343
+ E E LK + QA + + +E ++EAAR QA L+Q EM
Sbjct: 2113 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2172
Query: 344 K-TALAEDQLRQQSQVEEQRVAALENQISEVSELLG------------TYEKAKQKDQLA 390
K AE LRQ++QV EQ + L Q+ E E A+Q+ Q+
Sbjct: 2173 KHKKFAEQTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2231
Query: 391 IQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKS 450
+ R+ +L + A +R+ + + + L+++ EK+K++ + AAR S
Sbjct: 2232 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ---RFLQEEAEKMKQVAEEAARLS 2288
Query: 451 QVTLDVEKLCDL-----------------EIMPSSEAADGEKATALYYQQELKQLKEEFE 493
+ +L L E M + + A KA A QQ+ + +E+
Sbjct: 2289 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2348
Query: 494 RYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEEL---EHQHQQEAD 550
R + + + + + + LEA +++ E+ + L+L E+ + + +++A
Sbjct: 2349 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2408
Query: 551 DWKQELARL-QQLHRQELERCQLDFRDRTLKLE-EELHKQRDRALAVLTEKDLELEQLRS 608
++++ + ++LHR EL + +TL+++ ++ +R + E + E E+L+
Sbjct: 2409 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2468
Query: 609 VALASGLPGRRSPVGGGGPGDPADTSSSDSL---TQALQLAAANEPTFFLYAEQLARKE- 664
A L + T + L TQALQ + +E L E+ +E
Sbjct: 2469 EAKLLQL-----------KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2517
Query: 665 -----------VEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQ 713
+ LR+++ R + ++ Q + RL+ EE Q E+ +R +
Sbjct: 2518 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS----MEEARRRQHEAEEGVRRK 2573
Query: 714 SREGANLE 721
E LE
Sbjct: 2574 QEELQQLE 2581
Score = 85.9 bits (211), Expect = 1e-16
Identities = 149/651 (22%), Positives = 273/651 (41%), Gaps = 94/651 (14%)
Query: 156 KRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEE---ERARLE 212
++ +L+ +LA + + + + K+R E + +K KQ LE + + E E ARL
Sbjct: 1752 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1811
Query: 213 G--ELKGLQEQIAETKA--------RLITQ------QHDRAQEQSDHALMLRE-----LQ 251
E Q Q+AE A R++ + + R + +++ AL +E L+
Sbjct: 1812 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1871
Query: 252 KLLQEERTQRQ-----------DLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVE 300
+L ++E QR+ D+E RL + R+A E+ +G T + R+VE
Sbjct: 1872 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL---ERQKGLVEDTLRQRRQVE 1928
Query: 301 E----LKSELQAIRDEKNQPDPRLQELQEEAA-RLKSHFQAQLQ---------QEMRKTA 346
E LK+ + K + + L ++ A L+S QA+L+ +E R+
Sbjct: 1929 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1988
Query: 347 LAEDQLRQQSQVEE----QRVAAL---ENQISEVSELLGTYEKAKQKDQLAIQKLKERI- 398
AE+++++ EE QR AAL E ++V E E+A+Q+ +Q +E
Sbjct: 1989 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2048
Query: 399 LQLDLENKTLALAASSR-SPLDSHGEESSLDVNVLKDKMEKLKRL--------LQVAARK 449
+L E K A A + L ++ ++ L+ + E +R +Q
Sbjct: 2049 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2108
Query: 450 SQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTK 509
+Q VE+ L+ + E A ++ K+ ++E R Q L+ K
Sbjct: 2109 AQSRRQVEEAERLK-QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2167
Query: 510 DGNLGKELEAAQE---QLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQE 566
D + K + A++ Q A+++++ +LRL EE +HQ ++ ++ A + RQ
Sbjct: 2168 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ- 2226
Query: 567 LERCQLDFRDRTLKLE-EELHKQRDRALA-----VLTEKD-------LELEQLRSVALAS 613
R Q++ +++++ EEL K + R A +L +KD E E+++ VA +
Sbjct: 2227 --RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA 2284
Query: 614 GLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQ 673
R V + D L Q LA ++ R + E L++Q
Sbjct: 2285 A----RLSVAAQEAARLRQLAEED-LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2339
Query: 674 KHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQSREGANLEYLK 724
K + + +LQ+ + ++ EE Q +E + Q A E LK
Sbjct: 2340 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2390
Score = 85.1 bits (209), Expect = 2e-16
Identities = 127/568 (22%), Positives = 233/568 (41%), Gaps = 86/568 (15%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAE---EERA 209
+V++ L ++ Q+ L+ A + E A L DK ++ L++ + K + EE A
Sbjct: 2229 QVEEELFSVRVQMEELSKLKARIEAEN---RALILRDKDNTQRFLQEEAEKMKQVAEEAA 2285
Query: 210 RLEGELKGLQEQIAETKARLITQ--QHDRAQEQSDHALMLRELQKLLQEERTQRQDLELR 267
RL +A +A + Q + D AQ+++ ML+E + +QE + + EL
Sbjct: 2286 RLS---------VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL- 2335
Query: 268 LEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEA 327
L++ +E + A E E +QL E + + L+A R R E+ EA
Sbjct: 2336 LQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ-------RQLEMSAEA 2386
Query: 328 ARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEE--QRVAALENQISEVSELLGTYEKAKQ 385
RLK + + R ED R + Q EE +++ E E L+ T E +Q
Sbjct: 2387 ERLKLRVAEMSRAQAR---AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2443
Query: 386 KDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQV 445
+ ++L+E I +L+ E K+K+++ +LLQ+
Sbjct: 2444 QSDHDAERLREAIAELERE----------------------------KEKLQQEAKLLQL 2475
Query: 446 AARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKS 505
+ + Q + L + + + S ++ + L Q + E+ K + + + +
Sbjct: 2476 KSEEMQTVQQEQLLQETQALQQSFLSE---------KDSLLQRERFIEQEKAKLEQLFQD 2526
Query: 506 KNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQ 565
+ K L +E + Q+Q+ + +++ ++ +H+ ++ ++EL +L+Q RQ
Sbjct: 2527 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2586
Query: 566 ELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGG 625
+ E + +L E+L ++ A L E VA LP R +
Sbjct: 2587 QEEL----LAEENQRLREQLQLLEEQHRAALAHS--EEVTASQVAATKTLPNGRDAL--D 2638
Query: 626 GPGDPADTSSS-DSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQL 684
GP A+ S D L + + E L AE+L R T++ + R +V H L
Sbjct: 2639 GPAAEAEPEHSFDGLRRKVSAQRLQE-AGILSAEELQRLAQGHTTVDELARREDVR-HYL 2696
Query: 685 QDR------LLEEGERHREEVAALQSHI 706
Q R LL+ AALQ +
Sbjct: 2697 QGRSSIAGLLLKATNEKLSVYAALQRQL 2724
Score = 37.4 bits (85), Expect = 0.053
Identities = 112/475 (23%), Positives = 193/475 (40%), Gaps = 72/475 (15%)
Query: 253 LLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKS-ELQAIRD 311
L+ + Q+ RLE +AL + L + L R+V+ ++S L R
Sbjct: 861 LVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRT 920
Query: 312 EKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALA-EDQLRQQSQVEEQRVAALENQI 370
K P+ + Q L L+ H+QA L+ ED+L + E+ + +
Sbjct: 921 LK--PEEQRQALHS----LELHYQAFLRDSQDAGGFGPEDRL-----MAEREYGSCSHHY 969
Query: 371 SEVSELLGTYEKAKQKDQLAIQKLKERILQLDL-ENKTLALAASSRSPLDSH-GEESSLD 428
++ + L + + + Q I +LK+ LQL+ E +T+ R PLD E +
Sbjct: 970 QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL---RLPLDKEPARECAQR 1026
Query: 429 VNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDL-EIMPSSEAADGEKATALYYQQELKQ 487
+ + +++ L + AR S + EK+ L E P++ E L ++++
Sbjct: 1027 IAEQQKAQAEVEGLGKGVARLSA---EAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1083
Query: 488 LKEEF-ERYKMRAQVVLKSKNTKDGNLG-----KELEAAQEQLAELKEKYISLRLSCEEL 541
L + E+ K + V+ ++ ++ KE +A L EL+ SL+ +
Sbjct: 1084 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1143
Query: 542 EHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLE---EELHKQRDRALAVLTE 598
E Q Q D + EL Q++ ER Q +R +++E E + + +R AVL +
Sbjct: 1144 EAQ-QPTFDALRDELRGAQEVG----ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1198
Query: 599 KDL---ELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFL 655
D+ ELEQL GR+ S+D L LQ A + +
Sbjct: 1199 TDVRQRELEQL----------GRQLRYY---------RESADPLGAWLQDARRRQEQ--I 1237
Query: 656 YAEQLARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNI 710
A LA + LR+++ LLEE ERH E+V Q ++ I
Sbjct: 1238 QAMPLADSQAVREQLRQEQ------------ALLEEIERHGEKVEECQRFAKQYI 1280
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 99.8 bits (247), Expect = 9e-21
Identities = 138/593 (23%), Positives = 257/593 (43%), Gaps = 63/593 (10%)
Query: 154 VDKRLHQLKTQLATLTSSLATVT-------QEKSRMEASYLADKKKMKQDLEDASNKAEE 206
VD R H ++L TLTS +E+ R+ A++++ ++E A K +
Sbjct: 1317 VDLRTHY--SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1374
Query: 207 -------ERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERT 259
+A+ E E K LQ+++ E R D Q++ R +Q+ LQ+ R
Sbjct: 1375 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-------RSIQEELQQLRQ 1427
Query: 260 QRQ-DLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDP 318
+ +++ + + A R E++ LQ + R+ + ELQA+R + +
Sbjct: 1428 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1487
Query: 319 RLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLG 378
+ ++ QEEA RL+ Q+Q E ++ AE +L + + E + + + + EL
Sbjct: 1488 QKRQAQEEAERLR----RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1543
Query: 379 TYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEK 438
E+A+++ + A + + R +Q+ LE + A +S S E+++ L+++
Sbjct: 1544 QAEEAERRLRQA-EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1602
Query: 439 LKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLK-EEFERYKM 497
+ +L + A R++Q + E+ + E A+ E E QLK E R ++
Sbjct: 1603 VAQLREEAERRAQQQAEAER--------AREEAERE--------LERWQLKANEALRLRL 1646
Query: 498 RAQVVLKSKNTKDGNLGKELEAAQEQL---AELKEKYISLR-LSCEELEHQHQQEADDWK 553
+A+ V + K+ K+ E A+ + + +E+ + R L+ +ELE Q Q +
Sbjct: 1647 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1706
Query: 554 QELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALAS 613
Q LA Q+L R E Q + + R L EE QR+ A A ++LE E + A
Sbjct: 1707 QRLAAEQELIRLRAETEQGE-QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1765
Query: 614 GLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQ 673
L + + S+S+ Q L+ A F AE+ AR ++Q
Sbjct: 1766 VL------LASKARAEEESRSTSEKSKQRLEAEAGR---FRELAEEAARLRALAEEAKRQ 1816
Query: 674 KHRLEVEVHQLQ---DRLLEEGERHREEVAALQSHIEKNIRDQSREGANLEYL 723
+ E + + + +R+L E E L++ E ++++ E L L
Sbjct: 1817 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1869
Score = 96.7 bits (239), Expect = 7e-20
Identities = 136/608 (22%), Positives = 258/608 (42%), Gaps = 91/608 (14%)
Query: 177 QEKSRMEASYLADKKKMKQDLEDASN---KAEEERARLEGELKGLQEQIAETKARLITQQ 233
+E +R + L + +++K +E+A +AE+E AR +L+ L ++ A+ + + +
Sbjct: 1998 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR---QLQ-LAQEAAQKRLQAEEKA 2053
Query: 234 HDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTK 293
H A +Q + +ELQ+ LQ+E++ L E R A A Q E Q++
Sbjct: 2054 HAFAVQQKE-----QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2108
Query: 294 QLTREVEELK----SELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQ------EMR 343
+ E E LK + QA + + +E ++EAAR QA L+Q EM
Sbjct: 2109 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2168
Query: 344 K-TALAEDQLRQQSQVEEQRVAALENQISEVSELLG------------TYEKAKQKDQLA 390
K AE LRQ++QV EQ + L Q+ E E A+Q+ Q+
Sbjct: 2169 KHKKFAEQTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2227
Query: 391 IQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKS 450
+ R+ +L + A +R+ + + + L+++ EK+K++ + AAR S
Sbjct: 2228 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ---RFLQEEAEKMKQVAEEAARLS 2284
Query: 451 QVTLDVEKLCDL-----------------EIMPSSEAADGEKATALYYQQELKQLKEEFE 493
+ +L L E M + + A KA A QQ+ + +E+
Sbjct: 2285 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2344
Query: 494 RYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEEL---EHQHQQEAD 550
R + + + + + + LEA +++ E+ + L+L E+ + + +++A
Sbjct: 2345 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2404
Query: 551 DWKQELARL-QQLHRQELERCQLDFRDRTLKLE-EELHKQRDRALAVLTEKDLELEQLRS 608
++++ + ++LHR EL + +TL+++ ++ +R + E + E E+L+
Sbjct: 2405 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2464
Query: 609 VALASGLPGRRSPVGGGGPGDPADTSSSDSL---TQALQLAAANEPTFFLYAEQLARKE- 664
A L + T + L TQALQ + +E L E+ +E
Sbjct: 2465 EAKLLQL-----------KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2513
Query: 665 -----------VEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQ 713
+ LR+++ R + ++ Q + RL+ EE Q E+ +R +
Sbjct: 2514 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS----MEEARRRQHEAEEGVRRK 2569
Query: 714 SREGANLE 721
E LE
Sbjct: 2570 QEELQQLE 2577
Score = 85.9 bits (211), Expect = 1e-16
Identities = 149/651 (22%), Positives = 273/651 (41%), Gaps = 94/651 (14%)
Query: 156 KRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEE---ERARLE 212
++ +L+ +LA + + + + K+R E + +K KQ LE + + E E ARL
Sbjct: 1748 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1807
Query: 213 G--ELKGLQEQIAETKA--------RLITQ------QHDRAQEQSDHALMLRE-----LQ 251
E Q Q+AE A R++ + + R + +++ AL +E L+
Sbjct: 1808 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1867
Query: 252 KLLQEERTQRQ-----------DLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVE 300
+L ++E QR+ D+E RL + R+A E+ +G T + R+VE
Sbjct: 1868 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL---ERQKGLVEDTLRQRRQVE 1924
Query: 301 E----LKSELQAIRDEKNQPDPRLQELQEEAA-RLKSHFQAQLQ---------QEMRKTA 346
E LK+ + K + + L ++ A L+S QA+L+ +E R+
Sbjct: 1925 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1984
Query: 347 LAEDQLRQQSQVEE----QRVAAL---ENQISEVSELLGTYEKAKQKDQLAIQKLKERI- 398
AE+++++ EE QR AAL E ++V E E+A+Q+ +Q +E
Sbjct: 1985 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2044
Query: 399 LQLDLENKTLALAASSR-SPLDSHGEESSLDVNVLKDKMEKLKRL--------LQVAARK 449
+L E K A A + L ++ ++ L+ + E +R +Q
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2104
Query: 450 SQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTK 509
+Q VE+ L+ + E A ++ K+ ++E R Q L+ K
Sbjct: 2105 AQSRRQVEEAERLK-QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2163
Query: 510 DGNLGKELEAAQE---QLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQE 566
D + K + A++ Q A+++++ +LRL EE +HQ ++ ++ A + RQ
Sbjct: 2164 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ- 2222
Query: 567 LERCQLDFRDRTLKLE-EELHKQRDRALA-----VLTEKD-------LELEQLRSVALAS 613
R Q++ +++++ EEL K + R A +L +KD E E+++ VA +
Sbjct: 2223 --RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA 2280
Query: 614 GLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQ 673
R V + D L Q LA ++ R + E L++Q
Sbjct: 2281 A----RLSVAAQEAARLRQLAEED-LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2335
Query: 674 KHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQSREGANLEYLK 724
K + + +LQ+ + ++ EE Q +E + Q A E LK
Sbjct: 2336 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2386
Score = 85.1 bits (209), Expect = 2e-16
Identities = 127/568 (22%), Positives = 233/568 (41%), Gaps = 86/568 (15%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAE---EERA 209
+V++ L ++ Q+ L+ A + E A L DK ++ L++ + K + EE A
Sbjct: 2225 QVEEELFSVRVQMEELSKLKARIEAEN---RALILRDKDNTQRFLQEEAEKMKQVAEEAA 2281
Query: 210 RLEGELKGLQEQIAETKARLITQ--QHDRAQEQSDHALMLRELQKLLQEERTQRQDLELR 267
RL +A +A + Q + D AQ+++ ML+E + +QE + + EL
Sbjct: 2282 RLS---------VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL- 2331
Query: 268 LEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEA 327
L++ +E + A E E +QL E + + L+A R R E+ EA
Sbjct: 2332 LQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ-------RQLEMSAEA 2382
Query: 328 ARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEE--QRVAALENQISEVSELLGTYEKAKQ 385
RLK + + R ED R + Q EE +++ E E L+ T E +Q
Sbjct: 2383 ERLKLRVAEMSRAQAR---AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2439
Query: 386 KDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQV 445
+ ++L+E I +L+ E K+K+++ +LLQ+
Sbjct: 2440 QSDHDAERLREAIAELERE----------------------------KEKLQQEAKLLQL 2471
Query: 446 AARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKS 505
+ + Q + L + + + S ++ + L Q + E+ K + + + +
Sbjct: 2472 KSEEMQTVQQEQLLQETQALQQSFLSE---------KDSLLQRERFIEQEKAKLEQLFQD 2522
Query: 506 KNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQ 565
+ K L +E + Q+Q+ + +++ ++ +H+ ++ ++EL +L+Q RQ
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2582
Query: 566 ELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGG 625
+ E + +L E+L ++ A L E VA LP R +
Sbjct: 2583 QEEL----LAEENQRLREQLQLLEEQHRAALAHS--EEVTASQVAATKTLPNGRDAL--D 2634
Query: 626 GPGDPADTSSS-DSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQL 684
GP A+ S D L + + E L AE+L R T++ + R +V H L
Sbjct: 2635 GPAAEAEPEHSFDGLRRKVSAQRLQE-AGILSAEELQRLAQGHTTVDELARREDVR-HYL 2692
Query: 685 QDR------LLEEGERHREEVAALQSHI 706
Q R LL+ AALQ +
Sbjct: 2693 QGRSSIAGLLLKATNEKLSVYAALQRQL 2720
Score = 37.4 bits (85), Expect = 0.053
Identities = 112/475 (23%), Positives = 193/475 (40%), Gaps = 72/475 (15%)
Query: 253 LLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKS-ELQAIRD 311
L+ + Q+ RLE +AL + L + L R+V+ ++S L R
Sbjct: 857 LVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRT 916
Query: 312 EKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALA-EDQLRQQSQVEEQRVAALENQI 370
K P+ + Q L L+ H+QA L+ ED+L + E+ + +
Sbjct: 917 LK--PEEQRQALHS----LELHYQAFLRDSQDAGGFGPEDRL-----MAEREYGSCSHHY 965
Query: 371 SEVSELLGTYEKAKQKDQLAIQKLKERILQLDL-ENKTLALAASSRSPLDSH-GEESSLD 428
++ + L + + + Q I +LK+ LQL+ E +T+ R PLD E +
Sbjct: 966 QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL---RLPLDKEPARECAQR 1022
Query: 429 VNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDL-EIMPSSEAADGEKATALYYQQELKQ 487
+ + +++ L + AR S + EK+ L E P++ E L ++++
Sbjct: 1023 IAEQQKAQAEVEGLGKGVARLSA---EAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1079
Query: 488 LKEEF-ERYKMRAQVVLKSKNTKDGNLG-----KELEAAQEQLAELKEKYISLRLSCEEL 541
L + E+ K + V+ ++ ++ KE +A L EL+ SL+ +
Sbjct: 1080 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1139
Query: 542 EHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLE---EELHKQRDRALAVLTE 598
E Q Q D + EL Q++ ER Q +R +++E E + + +R AVL +
Sbjct: 1140 EAQ-QPTFDALRDELRGAQEVG----ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1194
Query: 599 KDL---ELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFL 655
D+ ELEQL GR+ S+D L LQ A + +
Sbjct: 1195 TDVRQRELEQL----------GRQLRYY---------RESADPLGAWLQDARRRQEQ--I 1233
Query: 656 YAEQLARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNI 710
A LA + LR+++ LLEE ERH E+V Q ++ I
Sbjct: 1234 QAMPLADSQAVREQLRQEQ------------ALLEEIERHGEKVEECQRFAKQYI 1276
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 99.8 bits (247), Expect = 9e-21
Identities = 138/593 (23%), Positives = 257/593 (43%), Gaps = 63/593 (10%)
Query: 154 VDKRLHQLKTQLATLTSSLATVT-------QEKSRMEASYLADKKKMKQDLEDASNKAEE 206
VD R H ++L TLTS +E+ R+ A++++ ++E A K +
Sbjct: 1285 VDLRTHY--SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1342
Query: 207 -------ERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERT 259
+A+ E E K LQ+++ E R D Q++ R +Q+ LQ+ R
Sbjct: 1343 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-------RSIQEELQQLRQ 1395
Query: 260 QRQ-DLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDP 318
+ +++ + + A R E++ LQ + R+ + ELQA+R + +
Sbjct: 1396 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1455
Query: 319 RLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLG 378
+ ++ QEEA RL+ Q+Q E ++ AE +L + + E + + + + EL
Sbjct: 1456 QKRQAQEEAERLR----RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1511
Query: 379 TYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEK 438
E+A+++ + A + + R +Q+ LE + A +S S E+++ L+++
Sbjct: 1512 QAEEAERRLRQA-EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1570
Query: 439 LKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLK-EEFERYKM 497
+ +L + A R++Q + E+ + E A+ E E QLK E R ++
Sbjct: 1571 VAQLREEAERRAQQQAEAER--------AREEAERE--------LERWQLKANEALRLRL 1614
Query: 498 RAQVVLKSKNTKDGNLGKELEAAQEQL---AELKEKYISLR-LSCEELEHQHQQEADDWK 553
+A+ V + K+ K+ E A+ + + +E+ + R L+ +ELE Q Q +
Sbjct: 1615 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1674
Query: 554 QELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALAS 613
Q LA Q+L R E Q + + R L EE QR+ A A ++LE E + A
Sbjct: 1675 QRLAAEQELIRLRAETEQGE-QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1733
Query: 614 GLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQ 673
L + + S+S+ Q L+ A F AE+ AR ++Q
Sbjct: 1734 VL------LASKARAEEESRSTSEKSKQRLEAEAGR---FRELAEEAARLRALAEEAKRQ 1784
Query: 674 KHRLEVEVHQLQ---DRLLEEGERHREEVAALQSHIEKNIRDQSREGANLEYL 723
+ E + + + +R+L E E L++ E ++++ E L L
Sbjct: 1785 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1837
Score = 96.7 bits (239), Expect = 7e-20
Identities = 136/608 (22%), Positives = 258/608 (42%), Gaps = 91/608 (14%)
Query: 177 QEKSRMEASYLADKKKMKQDLEDASN---KAEEERARLEGELKGLQEQIAETKARLITQQ 233
+E +R + L + +++K +E+A +AE+E AR +L+ L ++ A+ + + +
Sbjct: 1966 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR---QLQ-LAQEAAQKRLQAEEKA 2021
Query: 234 HDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTK 293
H A +Q + +ELQ+ LQ+E++ L E R A A Q E Q++
Sbjct: 2022 HAFAVQQKE-----QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2076
Query: 294 QLTREVEELK----SELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQ------EMR 343
+ E E LK + QA + + +E ++EAAR QA L+Q EM
Sbjct: 2077 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2136
Query: 344 K-TALAEDQLRQQSQVEEQRVAALENQISEVSELLG------------TYEKAKQKDQLA 390
K AE LRQ++QV EQ + L Q+ E E A+Q+ Q+
Sbjct: 2137 KHKKFAEQTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2195
Query: 391 IQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKS 450
+ R+ +L + A +R+ + + + L+++ EK+K++ + AAR S
Sbjct: 2196 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ---RFLQEEAEKMKQVAEEAARLS 2252
Query: 451 QVTLDVEKLCDL-----------------EIMPSSEAADGEKATALYYQQELKQLKEEFE 493
+ +L L E M + + A KA A QQ+ + +E+
Sbjct: 2253 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2312
Query: 494 RYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEEL---EHQHQQEAD 550
R + + + + + + LEA +++ E+ + L+L E+ + + +++A
Sbjct: 2313 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2372
Query: 551 DWKQELARL-QQLHRQELERCQLDFRDRTLKLE-EELHKQRDRALAVLTEKDLELEQLRS 608
++++ + ++LHR EL + +TL+++ ++ +R + E + E E+L+
Sbjct: 2373 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2432
Query: 609 VALASGLPGRRSPVGGGGPGDPADTSSSDSL---TQALQLAAANEPTFFLYAEQLARKE- 664
A L + T + L TQALQ + +E L E+ +E
Sbjct: 2433 EAKLLQL-----------KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2481
Query: 665 -----------VEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQ 713
+ LR+++ R + ++ Q + RL+ EE Q E+ +R +
Sbjct: 2482 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS----MEEARRRQHEAEEGVRRK 2537
Query: 714 SREGANLE 721
E LE
Sbjct: 2538 QEELQQLE 2545
Score = 85.9 bits (211), Expect = 1e-16
Identities = 149/651 (22%), Positives = 273/651 (41%), Gaps = 94/651 (14%)
Query: 156 KRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEE---ERARLE 212
++ +L+ +LA + + + + K+R E + +K KQ LE + + E E ARL
Sbjct: 1716 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1775
Query: 213 G--ELKGLQEQIAETKA--------RLITQ------QHDRAQEQSDHALMLRE-----LQ 251
E Q Q+AE A R++ + + R + +++ AL +E L+
Sbjct: 1776 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1835
Query: 252 KLLQEERTQRQ-----------DLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVE 300
+L ++E QR+ D+E RL + R+A E+ +G T + R+VE
Sbjct: 1836 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL---ERQKGLVEDTLRQRRQVE 1892
Query: 301 E----LKSELQAIRDEKNQPDPRLQELQEEAA-RLKSHFQAQLQ---------QEMRKTA 346
E LK+ + K + + L ++ A L+S QA+L+ +E R+
Sbjct: 1893 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1952
Query: 347 LAEDQLRQQSQVEE----QRVAAL---ENQISEVSELLGTYEKAKQKDQLAIQKLKERI- 398
AE+++++ EE QR AAL E ++V E E+A+Q+ +Q +E
Sbjct: 1953 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2012
Query: 399 LQLDLENKTLALAASSR-SPLDSHGEESSLDVNVLKDKMEKLKRL--------LQVAARK 449
+L E K A A + L ++ ++ L+ + E +R +Q
Sbjct: 2013 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2072
Query: 450 SQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTK 509
+Q VE+ L+ + E A ++ K+ ++E R Q L+ K
Sbjct: 2073 AQSRRQVEEAERLK-QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2131
Query: 510 DGNLGKELEAAQE---QLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQE 566
D + K + A++ Q A+++++ +LRL EE +HQ ++ ++ A + RQ
Sbjct: 2132 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ- 2190
Query: 567 LERCQLDFRDRTLKLE-EELHKQRDRALA-----VLTEKD-------LELEQLRSVALAS 613
R Q++ +++++ EEL K + R A +L +KD E E+++ VA +
Sbjct: 2191 --RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA 2248
Query: 614 GLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQ 673
R V + D L Q LA ++ R + E L++Q
Sbjct: 2249 A----RLSVAAQEAARLRQLAEED-LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2303
Query: 674 KHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQSREGANLEYLK 724
K + + +LQ+ + ++ EE Q +E + Q A E LK
Sbjct: 2304 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2354
Score = 85.1 bits (209), Expect = 2e-16
Identities = 127/568 (22%), Positives = 233/568 (41%), Gaps = 86/568 (15%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAE---EERA 209
+V++ L ++ Q+ L+ A + E A L DK ++ L++ + K + EE A
Sbjct: 2193 QVEEELFSVRVQMEELSKLKARIEAEN---RALILRDKDNTQRFLQEEAEKMKQVAEEAA 2249
Query: 210 RLEGELKGLQEQIAETKARLITQ--QHDRAQEQSDHALMLRELQKLLQEERTQRQDLELR 267
RL +A +A + Q + D AQ+++ ML+E + +QE + + EL
Sbjct: 2250 RLS---------VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL- 2299
Query: 268 LEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEA 327
L++ +E + A E E +QL E + + L+A R R E+ EA
Sbjct: 2300 LQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ-------RQLEMSAEA 2350
Query: 328 ARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEE--QRVAALENQISEVSELLGTYEKAKQ 385
RLK + + R ED R + Q EE +++ E E L+ T E +Q
Sbjct: 2351 ERLKLRVAEMSRAQAR---AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2407
Query: 386 KDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQV 445
+ ++L+E I +L+ E K+K+++ +LLQ+
Sbjct: 2408 QSDHDAERLREAIAELERE----------------------------KEKLQQEAKLLQL 2439
Query: 446 AARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKS 505
+ + Q + L + + + S ++ + L Q + E+ K + + + +
Sbjct: 2440 KSEEMQTVQQEQLLQETQALQQSFLSE---------KDSLLQRERFIEQEKAKLEQLFQD 2490
Query: 506 KNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQ 565
+ K L +E + Q+Q+ + +++ ++ +H+ ++ ++EL +L+Q RQ
Sbjct: 2491 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2550
Query: 566 ELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGG 625
+ E + +L E+L ++ A L E VA LP R +
Sbjct: 2551 QEEL----LAEENQRLREQLQLLEEQHRAALAHS--EEVTASQVAATKTLPNGRDAL--D 2602
Query: 626 GPGDPADTSSS-DSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQL 684
GP A+ S D L + + E L AE+L R T++ + R +V H L
Sbjct: 2603 GPAAEAEPEHSFDGLRRKVSAQRLQE-AGILSAEELQRLAQGHTTVDELARREDVR-HYL 2660
Query: 685 QDR------LLEEGERHREEVAALQSHI 706
Q R LL+ AALQ +
Sbjct: 2661 QGRSSIAGLLLKATNEKLSVYAALQRQL 2688
Score = 37.4 bits (85), Expect = 0.053
Identities = 112/475 (23%), Positives = 193/475 (40%), Gaps = 72/475 (15%)
Query: 253 LLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKS-ELQAIRD 311
L+ + Q+ RLE +AL + L + L R+V+ ++S L R
Sbjct: 825 LVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRT 884
Query: 312 EKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALA-EDQLRQQSQVEEQRVAALENQI 370
K P+ + Q L L+ H+QA L+ ED+L + E+ + +
Sbjct: 885 LK--PEEQRQALHS----LELHYQAFLRDSQDAGGFGPEDRL-----MAEREYGSCSHHY 933
Query: 371 SEVSELLGTYEKAKQKDQLAIQKLKERILQLDL-ENKTLALAASSRSPLDSH-GEESSLD 428
++ + L + + + Q I +LK+ LQL+ E +T+ R PLD E +
Sbjct: 934 QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL---RLPLDKEPARECAQR 990
Query: 429 VNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDL-EIMPSSEAADGEKATALYYQQELKQ 487
+ + +++ L + AR S + EK+ L E P++ E L ++++
Sbjct: 991 IAEQQKAQAEVEGLGKGVARLSA---EAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1047
Query: 488 LKEEF-ERYKMRAQVVLKSKNTKDGNLG-----KELEAAQEQLAELKEKYISLRLSCEEL 541
L + E+ K + V+ ++ ++ KE +A L EL+ SL+ +
Sbjct: 1048 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1107
Query: 542 EHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLE---EELHKQRDRALAVLTE 598
E Q Q D + EL Q++ ER Q +R +++E E + + +R AVL +
Sbjct: 1108 EAQ-QPTFDALRDELRGAQEVG----ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1162
Query: 599 KDL---ELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFL 655
D+ ELEQL GR+ S+D L LQ A + +
Sbjct: 1163 TDVRQRELEQL----------GRQLRYY---------RESADPLGAWLQDARRRQEQ--I 1201
Query: 656 YAEQLARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNI 710
A LA + LR+++ LLEE ERH E+V Q ++ I
Sbjct: 1202 QAMPLADSQAVREQLRQEQ------------ALLEEIERHGEKVEECQRFAKQYI 1244
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 99.8 bits (247), Expect = 9e-21
Identities = 138/593 (23%), Positives = 257/593 (43%), Gaps = 63/593 (10%)
Query: 154 VDKRLHQLKTQLATLTSSLATVT-------QEKSRMEASYLADKKKMKQDLEDASNKAEE 206
VD R H ++L TLTS +E+ R+ A++++ ++E A K +
Sbjct: 1454 VDLRTHY--SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1511
Query: 207 -------ERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERT 259
+A+ E E K LQ+++ E R D Q++ R +Q+ LQ+ R
Sbjct: 1512 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-------RSIQEELQQLRQ 1564
Query: 260 QRQ-DLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDP 318
+ +++ + + A R E++ LQ + R+ + ELQA+R + +
Sbjct: 1565 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1624
Query: 319 RLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLG 378
+ ++ QEEA RL+ Q+Q E ++ AE +L + + E + + + + EL
Sbjct: 1625 QKRQAQEEAERLR----RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1680
Query: 379 TYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEK 438
E+A+++ + A + + R +Q+ LE + A +S S E+++ L+++
Sbjct: 1681 QAEEAERRLRQA-EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1739
Query: 439 LKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLK-EEFERYKM 497
+ +L + A R++Q + E+ + E A+ E E QLK E R ++
Sbjct: 1740 VAQLREEAERRAQQQAEAER--------AREEAERE--------LERWQLKANEALRLRL 1783
Query: 498 RAQVVLKSKNTKDGNLGKELEAAQEQL---AELKEKYISLR-LSCEELEHQHQQEADDWK 553
+A+ V + K+ K+ E A+ + + +E+ + R L+ +ELE Q Q +
Sbjct: 1784 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1843
Query: 554 QELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALAS 613
Q LA Q+L R E Q + + R L EE QR+ A A ++LE E + A
Sbjct: 1844 QRLAAEQELIRLRAETEQGE-QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1902
Query: 614 GLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQ 673
L + + S+S+ Q L+ A F AE+ AR ++Q
Sbjct: 1903 VL------LASKARAEEESRSTSEKSKQRLEAEAGR---FRELAEEAARLRALAEEAKRQ 1953
Query: 674 KHRLEVEVHQLQ---DRLLEEGERHREEVAALQSHIEKNIRDQSREGANLEYL 723
+ E + + + +R+L E E L++ E ++++ E L L
Sbjct: 1954 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 2006
Score = 96.7 bits (239), Expect = 7e-20
Identities = 136/608 (22%), Positives = 258/608 (42%), Gaps = 91/608 (14%)
Query: 177 QEKSRMEASYLADKKKMKQDLEDASN---KAEEERARLEGELKGLQEQIAETKARLITQQ 233
+E +R + L + +++K +E+A +AE+E AR +L+ L ++ A+ + + +
Sbjct: 2135 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR---QLQ-LAQEAAQKRLQAEEKA 2190
Query: 234 HDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTK 293
H A +Q + +ELQ+ LQ+E++ L E R A A Q E Q++
Sbjct: 2191 HAFAVQQKE-----QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2245
Query: 294 QLTREVEELK----SELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQ------EMR 343
+ E E LK + QA + + +E ++EAAR QA L+Q EM
Sbjct: 2246 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2305
Query: 344 K-TALAEDQLRQQSQVEEQRVAALENQISEVSELLG------------TYEKAKQKDQLA 390
K AE LRQ++QV EQ + L Q+ E E A+Q+ Q+
Sbjct: 2306 KHKKFAEQTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2364
Query: 391 IQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKS 450
+ R+ +L + A +R+ + + + L+++ EK+K++ + AAR S
Sbjct: 2365 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ---RFLQEEAEKMKQVAEEAARLS 2421
Query: 451 QVTLDVEKLCDL-----------------EIMPSSEAADGEKATALYYQQELKQLKEEFE 493
+ +L L E M + + A KA A QQ+ + +E+
Sbjct: 2422 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2481
Query: 494 RYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEEL---EHQHQQEAD 550
R + + + + + + LEA +++ E+ + L+L E+ + + +++A
Sbjct: 2482 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2541
Query: 551 DWKQELARL-QQLHRQELERCQLDFRDRTLKLE-EELHKQRDRALAVLTEKDLELEQLRS 608
++++ + ++LHR EL + +TL+++ ++ +R + E + E E+L+
Sbjct: 2542 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2601
Query: 609 VALASGLPGRRSPVGGGGPGDPADTSSSDSL---TQALQLAAANEPTFFLYAEQLARKE- 664
A L + T + L TQALQ + +E L E+ +E
Sbjct: 2602 EAKLLQL-----------KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2650
Query: 665 -----------VEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQ 713
+ LR+++ R + ++ Q + RL+ EE Q E+ +R +
Sbjct: 2651 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS----MEEARRRQHEAEEGVRRK 2706
Query: 714 SREGANLE 721
E LE
Sbjct: 2707 QEELQQLE 2714
Score = 85.9 bits (211), Expect = 1e-16
Identities = 149/651 (22%), Positives = 273/651 (41%), Gaps = 94/651 (14%)
Query: 156 KRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEE---ERARLE 212
++ +L+ +LA + + + + K+R E + +K KQ LE + + E E ARL
Sbjct: 1885 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1944
Query: 213 G--ELKGLQEQIAETKA--------RLITQ------QHDRAQEQSDHALMLRE-----LQ 251
E Q Q+AE A R++ + + R + +++ AL +E L+
Sbjct: 1945 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 2004
Query: 252 KLLQEERTQRQ-----------DLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVE 300
+L ++E QR+ D+E RL + R+A E+ +G T + R+VE
Sbjct: 2005 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL---ERQKGLVEDTLRQRRQVE 2061
Query: 301 E----LKSELQAIRDEKNQPDPRLQELQEEAA-RLKSHFQAQLQ---------QEMRKTA 346
E LK+ + K + + L ++ A L+S QA+L+ +E R+
Sbjct: 2062 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 2121
Query: 347 LAEDQLRQQSQVEE----QRVAAL---ENQISEVSELLGTYEKAKQKDQLAIQKLKERI- 398
AE+++++ EE QR AAL E ++V E E+A+Q+ +Q +E
Sbjct: 2122 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2181
Query: 399 LQLDLENKTLALAASSR-SPLDSHGEESSLDVNVLKDKMEKLKRL--------LQVAARK 449
+L E K A A + L ++ ++ L+ + E +R +Q
Sbjct: 2182 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2241
Query: 450 SQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTK 509
+Q VE+ L+ + E A ++ K+ ++E R Q L+ K
Sbjct: 2242 AQSRRQVEEAERLK-QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2300
Query: 510 DGNLGKELEAAQE---QLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQE 566
D + K + A++ Q A+++++ +LRL EE +HQ ++ ++ A + RQ
Sbjct: 2301 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ- 2359
Query: 567 LERCQLDFRDRTLKLE-EELHKQRDRALA-----VLTEKD-------LELEQLRSVALAS 613
R Q++ +++++ EEL K + R A +L +KD E E+++ VA +
Sbjct: 2360 --RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA 2417
Query: 614 GLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQ 673
R V + D L Q LA ++ R + E L++Q
Sbjct: 2418 A----RLSVAAQEAARLRQLAEED-LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2472
Query: 674 KHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQSREGANLEYLK 724
K + + +LQ+ + ++ EE Q +E + Q A E LK
Sbjct: 2473 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2523
Score = 85.1 bits (209), Expect = 2e-16
Identities = 127/568 (22%), Positives = 233/568 (41%), Gaps = 86/568 (15%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAE---EERA 209
+V++ L ++ Q+ L+ A + E A L DK ++ L++ + K + EE A
Sbjct: 2362 QVEEELFSVRVQMEELSKLKARIEAEN---RALILRDKDNTQRFLQEEAEKMKQVAEEAA 2418
Query: 210 RLEGELKGLQEQIAETKARLITQ--QHDRAQEQSDHALMLRELQKLLQEERTQRQDLELR 267
RL +A +A + Q + D AQ+++ ML+E + +QE + + EL
Sbjct: 2419 RLS---------VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL- 2468
Query: 268 LEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEA 327
L++ +E + A E E +QL E + + L+A R R E+ EA
Sbjct: 2469 LQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ-------RQLEMSAEA 2519
Query: 328 ARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEE--QRVAALENQISEVSELLGTYEKAKQ 385
RLK + + R ED R + Q EE +++ E E L+ T E +Q
Sbjct: 2520 ERLKLRVAEMSRAQAR---AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2576
Query: 386 KDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQV 445
+ ++L+E I +L+ E K+K+++ +LLQ+
Sbjct: 2577 QSDHDAERLREAIAELERE----------------------------KEKLQQEAKLLQL 2608
Query: 446 AARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKS 505
+ + Q + L + + + S ++ + L Q + E+ K + + + +
Sbjct: 2609 KSEEMQTVQQEQLLQETQALQQSFLSE---------KDSLLQRERFIEQEKAKLEQLFQD 2659
Query: 506 KNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQ 565
+ K L +E + Q+Q+ + +++ ++ +H+ ++ ++EL +L+Q RQ
Sbjct: 2660 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2719
Query: 566 ELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGG 625
+ E + +L E+L ++ A L E VA LP R +
Sbjct: 2720 QEEL----LAEENQRLREQLQLLEEQHRAALAHS--EEVTASQVAATKTLPNGRDAL--D 2771
Query: 626 GPGDPADTSSS-DSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQL 684
GP A+ S D L + + E L AE+L R T++ + R +V H L
Sbjct: 2772 GPAAEAEPEHSFDGLRRKVSAQRLQE-AGILSAEELQRLAQGHTTVDELARREDVR-HYL 2829
Query: 685 QDR------LLEEGERHREEVAALQSHI 706
Q R LL+ AALQ +
Sbjct: 2830 QGRSSIAGLLLKATNEKLSVYAALQRQL 2857
Score = 37.4 bits (85), Expect = 0.053
Identities = 112/475 (23%), Positives = 193/475 (40%), Gaps = 72/475 (15%)
Query: 253 LLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKS-ELQAIRD 311
L+ + Q+ RLE +AL + L + L R+V+ ++S L R
Sbjct: 994 LVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRT 1053
Query: 312 EKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALA-EDQLRQQSQVEEQRVAALENQI 370
K P+ + Q L L+ H+QA L+ ED+L + E+ + +
Sbjct: 1054 LK--PEEQRQALHS----LELHYQAFLRDSQDAGGFGPEDRL-----MAEREYGSCSHHY 1102
Query: 371 SEVSELLGTYEKAKQKDQLAIQKLKERILQLDL-ENKTLALAASSRSPLDSH-GEESSLD 428
++ + L + + + Q I +LK+ LQL+ E +T+ R PLD E +
Sbjct: 1103 QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL---RLPLDKEPARECAQR 1159
Query: 429 VNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDL-EIMPSSEAADGEKATALYYQQELKQ 487
+ + +++ L + AR S + EK+ L E P++ E L ++++
Sbjct: 1160 IAEQQKAQAEVEGLGKGVARLSA---EAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1216
Query: 488 LKEEF-ERYKMRAQVVLKSKNTKDGNLG-----KELEAAQEQLAELKEKYISLRLSCEEL 541
L + E+ K + V+ ++ ++ KE +A L EL+ SL+ +
Sbjct: 1217 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1276
Query: 542 EHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLE---EELHKQRDRALAVLTE 598
E Q Q D + EL Q++ ER Q +R +++E E + + +R AVL +
Sbjct: 1277 EAQ-QPTFDALRDELRGAQEVG----ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1331
Query: 599 KDL---ELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFL 655
D+ ELEQL GR+ S+D L LQ A + +
Sbjct: 1332 TDVRQRELEQL----------GRQLRYY---------RESADPLGAWLQDARRRQEQ--I 1370
Query: 656 YAEQLARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNI 710
A LA + LR+++ LLEE ERH E+V Q ++ I
Sbjct: 1371 QAMPLADSQAVREQLRQEQ------------ALLEEIERHGEKVEECQRFAKQYI 1413
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 99.8 bits (247), Expect = 9e-21
Identities = 138/593 (23%), Positives = 257/593 (43%), Gaps = 63/593 (10%)
Query: 154 VDKRLHQLKTQLATLTSSLATVT-------QEKSRMEASYLADKKKMKQDLEDASNKAEE 206
VD R H ++L TLTS +E+ R+ A++++ ++E A K +
Sbjct: 1295 VDLRTHY--SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1352
Query: 207 -------ERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERT 259
+A+ E E K LQ+++ E R D Q++ R +Q+ LQ+ R
Sbjct: 1353 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-------RSIQEELQQLRQ 1405
Query: 260 QRQ-DLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDP 318
+ +++ + + A R E++ LQ + R+ + ELQA+R + +
Sbjct: 1406 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1465
Query: 319 RLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLG 378
+ ++ QEEA RL+ Q+Q E ++ AE +L + + E + + + + EL
Sbjct: 1466 QKRQAQEEAERLR----RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1521
Query: 379 TYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEK 438
E+A+++ + A + + R +Q+ LE + A +S S E+++ L+++
Sbjct: 1522 QAEEAERRLRQA-EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1580
Query: 439 LKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLK-EEFERYKM 497
+ +L + A R++Q + E+ + E A+ E E QLK E R ++
Sbjct: 1581 VAQLREEAERRAQQQAEAER--------AREEAERE--------LERWQLKANEALRLRL 1624
Query: 498 RAQVVLKSKNTKDGNLGKELEAAQEQL---AELKEKYISLR-LSCEELEHQHQQEADDWK 553
+A+ V + K+ K+ E A+ + + +E+ + R L+ +ELE Q Q +
Sbjct: 1625 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1684
Query: 554 QELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALAS 613
Q LA Q+L R E Q + + R L EE QR+ A A ++LE E + A
Sbjct: 1685 QRLAAEQELIRLRAETEQGE-QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1743
Query: 614 GLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQ 673
L + + S+S+ Q L+ A F AE+ AR ++Q
Sbjct: 1744 VL------LASKARAEEESRSTSEKSKQRLEAEAGR---FRELAEEAARLRALAEEAKRQ 1794
Query: 674 KHRLEVEVHQLQ---DRLLEEGERHREEVAALQSHIEKNIRDQSREGANLEYL 723
+ E + + + +R+L E E L++ E ++++ E L L
Sbjct: 1795 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1847
Score = 96.7 bits (239), Expect = 7e-20
Identities = 136/608 (22%), Positives = 258/608 (42%), Gaps = 91/608 (14%)
Query: 177 QEKSRMEASYLADKKKMKQDLEDASN---KAEEERARLEGELKGLQEQIAETKARLITQQ 233
+E +R + L + +++K +E+A +AE+E AR +L+ L ++ A+ + + +
Sbjct: 1976 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR---QLQ-LAQEAAQKRLQAEEKA 2031
Query: 234 HDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTK 293
H A +Q + +ELQ+ LQ+E++ L E R A A Q E Q++
Sbjct: 2032 HAFAVQQKE-----QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2086
Query: 294 QLTREVEELK----SELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQ------EMR 343
+ E E LK + QA + + +E ++EAAR QA L+Q EM
Sbjct: 2087 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2146
Query: 344 K-TALAEDQLRQQSQVEEQRVAALENQISEVSELLG------------TYEKAKQKDQLA 390
K AE LRQ++QV EQ + L Q+ E E A+Q+ Q+
Sbjct: 2147 KHKKFAEQTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2205
Query: 391 IQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKS 450
+ R+ +L + A +R+ + + + L+++ EK+K++ + AAR S
Sbjct: 2206 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ---RFLQEEAEKMKQVAEEAARLS 2262
Query: 451 QVTLDVEKLCDL-----------------EIMPSSEAADGEKATALYYQQELKQLKEEFE 493
+ +L L E M + + A KA A QQ+ + +E+
Sbjct: 2263 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2322
Query: 494 RYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEEL---EHQHQQEAD 550
R + + + + + + LEA +++ E+ + L+L E+ + + +++A
Sbjct: 2323 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2382
Query: 551 DWKQELARL-QQLHRQELERCQLDFRDRTLKLE-EELHKQRDRALAVLTEKDLELEQLRS 608
++++ + ++LHR EL + +TL+++ ++ +R + E + E E+L+
Sbjct: 2383 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2442
Query: 609 VALASGLPGRRSPVGGGGPGDPADTSSSDSL---TQALQLAAANEPTFFLYAEQLARKE- 664
A L + T + L TQALQ + +E L E+ +E
Sbjct: 2443 EAKLLQL-----------KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2491
Query: 665 -----------VEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQ 713
+ LR+++ R + ++ Q + RL+ EE Q E+ +R +
Sbjct: 2492 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS----MEEARRRQHEAEEGVRRK 2547
Query: 714 SREGANLE 721
E LE
Sbjct: 2548 QEELQQLE 2555
Score = 85.9 bits (211), Expect = 1e-16
Identities = 149/651 (22%), Positives = 273/651 (41%), Gaps = 94/651 (14%)
Query: 156 KRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEE---ERARLE 212
++ +L+ +LA + + + + K+R E + +K KQ LE + + E E ARL
Sbjct: 1726 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1785
Query: 213 G--ELKGLQEQIAETKA--------RLITQ------QHDRAQEQSDHALMLRE-----LQ 251
E Q Q+AE A R++ + + R + +++ AL +E L+
Sbjct: 1786 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1845
Query: 252 KLLQEERTQRQ-----------DLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVE 300
+L ++E QR+ D+E RL + R+A E+ +G T + R+VE
Sbjct: 1846 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL---ERQKGLVEDTLRQRRQVE 1902
Query: 301 E----LKSELQAIRDEKNQPDPRLQELQEEAA-RLKSHFQAQLQ---------QEMRKTA 346
E LK+ + K + + L ++ A L+S QA+L+ +E R+
Sbjct: 1903 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1962
Query: 347 LAEDQLRQQSQVEE----QRVAAL---ENQISEVSELLGTYEKAKQKDQLAIQKLKERI- 398
AE+++++ EE QR AAL E ++V E E+A+Q+ +Q +E
Sbjct: 1963 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2022
Query: 399 LQLDLENKTLALAASSR-SPLDSHGEESSLDVNVLKDKMEKLKRL--------LQVAARK 449
+L E K A A + L ++ ++ L+ + E +R +Q
Sbjct: 2023 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2082
Query: 450 SQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTK 509
+Q VE+ L+ + E A ++ K+ ++E R Q L+ K
Sbjct: 2083 AQSRRQVEEAERLK-QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2141
Query: 510 DGNLGKELEAAQE---QLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQE 566
D + K + A++ Q A+++++ +LRL EE +HQ ++ ++ A + RQ
Sbjct: 2142 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ- 2200
Query: 567 LERCQLDFRDRTLKLE-EELHKQRDRALA-----VLTEKD-------LELEQLRSVALAS 613
R Q++ +++++ EEL K + R A +L +KD E E+++ VA +
Sbjct: 2201 --RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA 2258
Query: 614 GLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQ 673
R V + D L Q LA ++ R + E L++Q
Sbjct: 2259 A----RLSVAAQEAARLRQLAEED-LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2313
Query: 674 KHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQSREGANLEYLK 724
K + + +LQ+ + ++ EE Q +E + Q A E LK
Sbjct: 2314 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2364
Score = 85.1 bits (209), Expect = 2e-16
Identities = 127/568 (22%), Positives = 233/568 (41%), Gaps = 86/568 (15%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAE---EERA 209
+V++ L ++ Q+ L+ A + E A L DK ++ L++ + K + EE A
Sbjct: 2203 QVEEELFSVRVQMEELSKLKARIEAEN---RALILRDKDNTQRFLQEEAEKMKQVAEEAA 2259
Query: 210 RLEGELKGLQEQIAETKARLITQ--QHDRAQEQSDHALMLRELQKLLQEERTQRQDLELR 267
RL +A +A + Q + D AQ+++ ML+E + +QE + + EL
Sbjct: 2260 RLS---------VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL- 2309
Query: 268 LEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEA 327
L++ +E + A E E +QL E + + L+A R R E+ EA
Sbjct: 2310 LQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ-------RQLEMSAEA 2360
Query: 328 ARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEE--QRVAALENQISEVSELLGTYEKAKQ 385
RLK + + R ED R + Q EE +++ E E L+ T E +Q
Sbjct: 2361 ERLKLRVAEMSRAQAR---AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2417
Query: 386 KDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQV 445
+ ++L+E I +L+ E K+K+++ +LLQ+
Sbjct: 2418 QSDHDAERLREAIAELERE----------------------------KEKLQQEAKLLQL 2449
Query: 446 AARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKS 505
+ + Q + L + + + S ++ + L Q + E+ K + + + +
Sbjct: 2450 KSEEMQTVQQEQLLQETQALQQSFLSE---------KDSLLQRERFIEQEKAKLEQLFQD 2500
Query: 506 KNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQ 565
+ K L +E + Q+Q+ + +++ ++ +H+ ++ ++EL +L+Q RQ
Sbjct: 2501 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2560
Query: 566 ELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGG 625
+ E + +L E+L ++ A L E VA LP R +
Sbjct: 2561 QEEL----LAEENQRLREQLQLLEEQHRAALAHS--EEVTASQVAATKTLPNGRDAL--D 2612
Query: 626 GPGDPADTSSS-DSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQL 684
GP A+ S D L + + E L AE+L R T++ + R +V H L
Sbjct: 2613 GPAAEAEPEHSFDGLRRKVSAQRLQE-AGILSAEELQRLAQGHTTVDELARREDVR-HYL 2670
Query: 685 QDR------LLEEGERHREEVAALQSHI 706
Q R LL+ AALQ +
Sbjct: 2671 QGRSSIAGLLLKATNEKLSVYAALQRQL 2698
Score = 37.4 bits (85), Expect = 0.053
Identities = 112/475 (23%), Positives = 193/475 (40%), Gaps = 72/475 (15%)
Query: 253 LLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKS-ELQAIRD 311
L+ + Q+ RLE +AL + L + L R+V+ ++S L R
Sbjct: 835 LVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRT 894
Query: 312 EKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALA-EDQLRQQSQVEEQRVAALENQI 370
K P+ + Q L L+ H+QA L+ ED+L + E+ + +
Sbjct: 895 LK--PEEQRQALHS----LELHYQAFLRDSQDAGGFGPEDRL-----MAEREYGSCSHHY 943
Query: 371 SEVSELLGTYEKAKQKDQLAIQKLKERILQLDL-ENKTLALAASSRSPLDSH-GEESSLD 428
++ + L + + + Q I +LK+ LQL+ E +T+ R PLD E +
Sbjct: 944 QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL---RLPLDKEPARECAQR 1000
Query: 429 VNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDL-EIMPSSEAADGEKATALYYQQELKQ 487
+ + +++ L + AR S + EK+ L E P++ E L ++++
Sbjct: 1001 IAEQQKAQAEVEGLGKGVARLSA---EAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1057
Query: 488 LKEEF-ERYKMRAQVVLKSKNTKDGNLG-----KELEAAQEQLAELKEKYISLRLSCEEL 541
L + E+ K + V+ ++ ++ KE +A L EL+ SL+ +
Sbjct: 1058 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1117
Query: 542 EHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLE---EELHKQRDRALAVLTE 598
E Q Q D + EL Q++ ER Q +R +++E E + + +R AVL +
Sbjct: 1118 EAQ-QPTFDALRDELRGAQEVG----ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1172
Query: 599 KDL---ELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFL 655
D+ ELEQL GR+ S+D L LQ A + +
Sbjct: 1173 TDVRQRELEQL----------GRQLRYY---------RESADPLGAWLQDARRRQEQ--I 1211
Query: 656 YAEQLARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNI 710
A LA + LR+++ LLEE ERH E+V Q ++ I
Sbjct: 1212 QAMPLADSQAVREQLRQEQ------------ALLEEIERHGEKVEECQRFAKQYI 1254
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 99.8 bits (247), Expect = 9e-21
Identities = 138/593 (23%), Positives = 257/593 (43%), Gaps = 63/593 (10%)
Query: 154 VDKRLHQLKTQLATLTSSLATVT-------QEKSRMEASYLADKKKMKQDLEDASNKAEE 206
VD R H ++L TLTS +E+ R+ A++++ ++E A K +
Sbjct: 1303 VDLRTHY--SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1360
Query: 207 -------ERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERT 259
+A+ E E K LQ+++ E R D Q++ R +Q+ LQ+ R
Sbjct: 1361 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-------RSIQEELQQLRQ 1413
Query: 260 QRQ-DLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDP 318
+ +++ + + A R E++ LQ + R+ + ELQA+R + +
Sbjct: 1414 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1473
Query: 319 RLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLG 378
+ ++ QEEA RL+ Q+Q E ++ AE +L + + E + + + + EL
Sbjct: 1474 QKRQAQEEAERLR----RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1529
Query: 379 TYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEK 438
E+A+++ + A + + R +Q+ LE + A +S S E+++ L+++
Sbjct: 1530 QAEEAERRLRQA-EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1588
Query: 439 LKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLK-EEFERYKM 497
+ +L + A R++Q + E+ + E A+ E E QLK E R ++
Sbjct: 1589 VAQLREEAERRAQQQAEAER--------AREEAERE--------LERWQLKANEALRLRL 1632
Query: 498 RAQVVLKSKNTKDGNLGKELEAAQEQL---AELKEKYISLR-LSCEELEHQHQQEADDWK 553
+A+ V + K+ K+ E A+ + + +E+ + R L+ +ELE Q Q +
Sbjct: 1633 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1692
Query: 554 QELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALAS 613
Q LA Q+L R E Q + + R L EE QR+ A A ++LE E + A
Sbjct: 1693 QRLAAEQELIRLRAETEQGE-QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1751
Query: 614 GLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQ 673
L + + S+S+ Q L+ A F AE+ AR ++Q
Sbjct: 1752 VL------LASKARAEEESRSTSEKSKQRLEAEAGR---FRELAEEAARLRALAEEAKRQ 1802
Query: 674 KHRLEVEVHQLQ---DRLLEEGERHREEVAALQSHIEKNIRDQSREGANLEYL 723
+ E + + + +R+L E E L++ E ++++ E L L
Sbjct: 1803 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1855
Score = 96.7 bits (239), Expect = 7e-20
Identities = 136/608 (22%), Positives = 258/608 (42%), Gaps = 91/608 (14%)
Query: 177 QEKSRMEASYLADKKKMKQDLEDASN---KAEEERARLEGELKGLQEQIAETKARLITQQ 233
+E +R + L + +++K +E+A +AE+E AR +L+ L ++ A+ + + +
Sbjct: 1984 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR---QLQ-LAQEAAQKRLQAEEKA 2039
Query: 234 HDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTK 293
H A +Q + +ELQ+ LQ+E++ L E R A A Q E Q++
Sbjct: 2040 HAFAVQQKE-----QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2094
Query: 294 QLTREVEELK----SELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQ------EMR 343
+ E E LK + QA + + +E ++EAAR QA L+Q EM
Sbjct: 2095 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2154
Query: 344 K-TALAEDQLRQQSQVEEQRVAALENQISEVSELLG------------TYEKAKQKDQLA 390
K AE LRQ++QV EQ + L Q+ E E A+Q+ Q+
Sbjct: 2155 KHKKFAEQTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2213
Query: 391 IQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKS 450
+ R+ +L + A +R+ + + + L+++ EK+K++ + AAR S
Sbjct: 2214 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ---RFLQEEAEKMKQVAEEAARLS 2270
Query: 451 QVTLDVEKLCDL-----------------EIMPSSEAADGEKATALYYQQELKQLKEEFE 493
+ +L L E M + + A KA A QQ+ + +E+
Sbjct: 2271 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2330
Query: 494 RYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEEL---EHQHQQEAD 550
R + + + + + + LEA +++ E+ + L+L E+ + + +++A
Sbjct: 2331 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2390
Query: 551 DWKQELARL-QQLHRQELERCQLDFRDRTLKLE-EELHKQRDRALAVLTEKDLELEQLRS 608
++++ + ++LHR EL + +TL+++ ++ +R + E + E E+L+
Sbjct: 2391 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2450
Query: 609 VALASGLPGRRSPVGGGGPGDPADTSSSDSL---TQALQLAAANEPTFFLYAEQLARKE- 664
A L + T + L TQALQ + +E L E+ +E
Sbjct: 2451 EAKLLQL-----------KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2499
Query: 665 -----------VEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQ 713
+ LR+++ R + ++ Q + RL+ EE Q E+ +R +
Sbjct: 2500 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS----MEEARRRQHEAEEGVRRK 2555
Query: 714 SREGANLE 721
E LE
Sbjct: 2556 QEELQQLE 2563
Score = 85.9 bits (211), Expect = 1e-16
Identities = 149/651 (22%), Positives = 273/651 (41%), Gaps = 94/651 (14%)
Query: 156 KRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEE---ERARLE 212
++ +L+ +LA + + + + K+R E + +K KQ LE + + E E ARL
Sbjct: 1734 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1793
Query: 213 G--ELKGLQEQIAETKA--------RLITQ------QHDRAQEQSDHALMLRE-----LQ 251
E Q Q+AE A R++ + + R + +++ AL +E L+
Sbjct: 1794 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1853
Query: 252 KLLQEERTQRQ-----------DLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVE 300
+L ++E QR+ D+E RL + R+A E+ +G T + R+VE
Sbjct: 1854 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL---ERQKGLVEDTLRQRRQVE 1910
Query: 301 E----LKSELQAIRDEKNQPDPRLQELQEEAA-RLKSHFQAQLQ---------QEMRKTA 346
E LK+ + K + + L ++ A L+S QA+L+ +E R+
Sbjct: 1911 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1970
Query: 347 LAEDQLRQQSQVEE----QRVAAL---ENQISEVSELLGTYEKAKQKDQLAIQKLKERI- 398
AE+++++ EE QR AAL E ++V E E+A+Q+ +Q +E
Sbjct: 1971 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2030
Query: 399 LQLDLENKTLALAASSR-SPLDSHGEESSLDVNVLKDKMEKLKRL--------LQVAARK 449
+L E K A A + L ++ ++ L+ + E +R +Q
Sbjct: 2031 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2090
Query: 450 SQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTK 509
+Q VE+ L+ + E A ++ K+ ++E R Q L+ K
Sbjct: 2091 AQSRRQVEEAERLK-QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2149
Query: 510 DGNLGKELEAAQE---QLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQE 566
D + K + A++ Q A+++++ +LRL EE +HQ ++ ++ A + RQ
Sbjct: 2150 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ- 2208
Query: 567 LERCQLDFRDRTLKLE-EELHKQRDRALA-----VLTEKD-------LELEQLRSVALAS 613
R Q++ +++++ EEL K + R A +L +KD E E+++ VA +
Sbjct: 2209 --RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA 2266
Query: 614 GLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQ 673
R V + D L Q LA ++ R + E L++Q
Sbjct: 2267 A----RLSVAAQEAARLRQLAEED-LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2321
Query: 674 KHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQSREGANLEYLK 724
K + + +LQ+ + ++ EE Q +E + Q A E LK
Sbjct: 2322 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2372
Score = 85.1 bits (209), Expect = 2e-16
Identities = 127/568 (22%), Positives = 233/568 (41%), Gaps = 86/568 (15%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAE---EERA 209
+V++ L ++ Q+ L+ A + E A L DK ++ L++ + K + EE A
Sbjct: 2211 QVEEELFSVRVQMEELSKLKARIEAEN---RALILRDKDNTQRFLQEEAEKMKQVAEEAA 2267
Query: 210 RLEGELKGLQEQIAETKARLITQ--QHDRAQEQSDHALMLRELQKLLQEERTQRQDLELR 267
RL +A +A + Q + D AQ+++ ML+E + +QE + + EL
Sbjct: 2268 RLS---------VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL- 2317
Query: 268 LEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEA 327
L++ +E + A E E +QL E + + L+A R R E+ EA
Sbjct: 2318 LQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ-------RQLEMSAEA 2368
Query: 328 ARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEE--QRVAALENQISEVSELLGTYEKAKQ 385
RLK + + R ED R + Q EE +++ E E L+ T E +Q
Sbjct: 2369 ERLKLRVAEMSRAQAR---AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2425
Query: 386 KDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQV 445
+ ++L+E I +L+ E K+K+++ +LLQ+
Sbjct: 2426 QSDHDAERLREAIAELERE----------------------------KEKLQQEAKLLQL 2457
Query: 446 AARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKS 505
+ + Q + L + + + S ++ + L Q + E+ K + + + +
Sbjct: 2458 KSEEMQTVQQEQLLQETQALQQSFLSE---------KDSLLQRERFIEQEKAKLEQLFQD 2508
Query: 506 KNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQ 565
+ K L +E + Q+Q+ + +++ ++ +H+ ++ ++EL +L+Q RQ
Sbjct: 2509 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2568
Query: 566 ELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGG 625
+ E + +L E+L ++ A L E VA LP R +
Sbjct: 2569 QEEL----LAEENQRLREQLQLLEEQHRAALAHS--EEVTASQVAATKTLPNGRDAL--D 2620
Query: 626 GPGDPADTSSS-DSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQL 684
GP A+ S D L + + E L AE+L R T++ + R +V H L
Sbjct: 2621 GPAAEAEPEHSFDGLRRKVSAQRLQE-AGILSAEELQRLAQGHTTVDELARREDVR-HYL 2678
Query: 685 QDR------LLEEGERHREEVAALQSHI 706
Q R LL+ AALQ +
Sbjct: 2679 QGRSSIAGLLLKATNEKLSVYAALQRQL 2706
Score = 37.4 bits (85), Expect = 0.053
Identities = 112/475 (23%), Positives = 193/475 (40%), Gaps = 72/475 (15%)
Query: 253 LLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKS-ELQAIRD 311
L+ + Q+ RLE +AL + L + L R+V+ ++S L R
Sbjct: 843 LVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRT 902
Query: 312 EKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALA-EDQLRQQSQVEEQRVAALENQI 370
K P+ + Q L L+ H+QA L+ ED+L + E+ + +
Sbjct: 903 LK--PEEQRQALHS----LELHYQAFLRDSQDAGGFGPEDRL-----MAEREYGSCSHHY 951
Query: 371 SEVSELLGTYEKAKQKDQLAIQKLKERILQLDL-ENKTLALAASSRSPLDSH-GEESSLD 428
++ + L + + + Q I +LK+ LQL+ E +T+ R PLD E +
Sbjct: 952 QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL---RLPLDKEPARECAQR 1008
Query: 429 VNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDL-EIMPSSEAADGEKATALYYQQELKQ 487
+ + +++ L + AR S + EK+ L E P++ E L ++++
Sbjct: 1009 IAEQQKAQAEVEGLGKGVARLSA---EAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1065
Query: 488 LKEEF-ERYKMRAQVVLKSKNTKDGNLG-----KELEAAQEQLAELKEKYISLRLSCEEL 541
L + E+ K + V+ ++ ++ KE +A L EL+ SL+ +
Sbjct: 1066 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1125
Query: 542 EHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLE---EELHKQRDRALAVLTE 598
E Q Q D + EL Q++ ER Q +R +++E E + + +R AVL +
Sbjct: 1126 EAQ-QPTFDALRDELRGAQEVG----ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1180
Query: 599 KDL---ELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFL 655
D+ ELEQL GR+ S+D L LQ A + +
Sbjct: 1181 TDVRQRELEQL----------GRQLRYY---------RESADPLGAWLQDARRRQEQ--I 1219
Query: 656 YAEQLARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNI 710
A LA + LR+++ LLEE ERH E+V Q ++ I
Sbjct: 1220 QAMPLADSQAVREQLRQEQ------------ALLEEIERHGEKVEECQRFAKQYI 1262
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 99.8 bits (247), Expect = 9e-21
Identities = 138/593 (23%), Positives = 257/593 (43%), Gaps = 63/593 (10%)
Query: 154 VDKRLHQLKTQLATLTSSLATVT-------QEKSRMEASYLADKKKMKQDLEDASNKAEE 206
VD R H ++L TLTS +E+ R+ A++++ ++E A K +
Sbjct: 1344 VDLRTHY--SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1401
Query: 207 -------ERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERT 259
+A+ E E K LQ+++ E R D Q++ R +Q+ LQ+ R
Sbjct: 1402 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-------RSIQEELQQLRQ 1454
Query: 260 QRQ-DLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDP 318
+ +++ + + A R E++ LQ + R+ + ELQA+R + +
Sbjct: 1455 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1514
Query: 319 RLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLG 378
+ ++ QEEA RL+ Q+Q E ++ AE +L + + E + + + + EL
Sbjct: 1515 QKRQAQEEAERLR----RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1570
Query: 379 TYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEK 438
E+A+++ + A + + R +Q+ LE + A +S S E+++ L+++
Sbjct: 1571 QAEEAERRLRQA-EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1629
Query: 439 LKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLK-EEFERYKM 497
+ +L + A R++Q + E+ + E A+ E E QLK E R ++
Sbjct: 1630 VAQLREEAERRAQQQAEAER--------AREEAERE--------LERWQLKANEALRLRL 1673
Query: 498 RAQVVLKSKNTKDGNLGKELEAAQEQL---AELKEKYISLR-LSCEELEHQHQQEADDWK 553
+A+ V + K+ K+ E A+ + + +E+ + R L+ +ELE Q Q +
Sbjct: 1674 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1733
Query: 554 QELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALAS 613
Q LA Q+L R E Q + + R L EE QR+ A A ++LE E + A
Sbjct: 1734 QRLAAEQELIRLRAETEQGE-QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1792
Query: 614 GLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQ 673
L + + S+S+ Q L+ A F AE+ AR ++Q
Sbjct: 1793 VL------LASKARAEEESRSTSEKSKQRLEAEAGR---FRELAEEAARLRALAEEAKRQ 1843
Query: 674 KHRLEVEVHQLQ---DRLLEEGERHREEVAALQSHIEKNIRDQSREGANLEYL 723
+ E + + + +R+L E E L++ E ++++ E L L
Sbjct: 1844 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1896
Score = 96.7 bits (239), Expect = 7e-20
Identities = 136/608 (22%), Positives = 258/608 (42%), Gaps = 91/608 (14%)
Query: 177 QEKSRMEASYLADKKKMKQDLEDASN---KAEEERARLEGELKGLQEQIAETKARLITQQ 233
+E +R + L + +++K +E+A +AE+E AR +L+ L ++ A+ + + +
Sbjct: 2025 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR---QLQ-LAQEAAQKRLQAEEKA 2080
Query: 234 HDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTK 293
H A +Q + +ELQ+ LQ+E++ L E R A A Q E Q++
Sbjct: 2081 HAFAVQQKE-----QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2135
Query: 294 QLTREVEELK----SELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQ------EMR 343
+ E E LK + QA + + +E ++EAAR QA L+Q EM
Sbjct: 2136 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2195
Query: 344 K-TALAEDQLRQQSQVEEQRVAALENQISEVSELLG------------TYEKAKQKDQLA 390
K AE LRQ++QV EQ + L Q+ E E A+Q+ Q+
Sbjct: 2196 KHKKFAEQTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2254
Query: 391 IQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKS 450
+ R+ +L + A +R+ + + + L+++ EK+K++ + AAR S
Sbjct: 2255 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ---RFLQEEAEKMKQVAEEAARLS 2311
Query: 451 QVTLDVEKLCDL-----------------EIMPSSEAADGEKATALYYQQELKQLKEEFE 493
+ +L L E M + + A KA A QQ+ + +E+
Sbjct: 2312 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2371
Query: 494 RYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEEL---EHQHQQEAD 550
R + + + + + + LEA +++ E+ + L+L E+ + + +++A
Sbjct: 2372 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2431
Query: 551 DWKQELARL-QQLHRQELERCQLDFRDRTLKLE-EELHKQRDRALAVLTEKDLELEQLRS 608
++++ + ++LHR EL + +TL+++ ++ +R + E + E E+L+
Sbjct: 2432 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2491
Query: 609 VALASGLPGRRSPVGGGGPGDPADTSSSDSL---TQALQLAAANEPTFFLYAEQLARKE- 664
A L + T + L TQALQ + +E L E+ +E
Sbjct: 2492 EAKLLQL-----------KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2540
Query: 665 -----------VEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQ 713
+ LR+++ R + ++ Q + RL+ EE Q E+ +R +
Sbjct: 2541 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS----MEEARRRQHEAEEGVRRK 2596
Query: 714 SREGANLE 721
E LE
Sbjct: 2597 QEELQQLE 2604
Score = 85.9 bits (211), Expect = 1e-16
Identities = 149/651 (22%), Positives = 273/651 (41%), Gaps = 94/651 (14%)
Query: 156 KRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEE---ERARLE 212
++ +L+ +LA + + + + K+R E + +K KQ LE + + E E ARL
Sbjct: 1775 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1834
Query: 213 G--ELKGLQEQIAETKA--------RLITQ------QHDRAQEQSDHALMLRE-----LQ 251
E Q Q+AE A R++ + + R + +++ AL +E L+
Sbjct: 1835 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1894
Query: 252 KLLQEERTQRQ-----------DLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVE 300
+L ++E QR+ D+E RL + R+A E+ +G T + R+VE
Sbjct: 1895 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL---ERQKGLVEDTLRQRRQVE 1951
Query: 301 E----LKSELQAIRDEKNQPDPRLQELQEEAA-RLKSHFQAQLQ---------QEMRKTA 346
E LK+ + K + + L ++ A L+S QA+L+ +E R+
Sbjct: 1952 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 2011
Query: 347 LAEDQLRQQSQVEE----QRVAAL---ENQISEVSELLGTYEKAKQKDQLAIQKLKERI- 398
AE+++++ EE QR AAL E ++V E E+A+Q+ +Q +E
Sbjct: 2012 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2071
Query: 399 LQLDLENKTLALAASSR-SPLDSHGEESSLDVNVLKDKMEKLKRL--------LQVAARK 449
+L E K A A + L ++ ++ L+ + E +R +Q
Sbjct: 2072 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2131
Query: 450 SQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTK 509
+Q VE+ L+ + E A ++ K+ ++E R Q L+ K
Sbjct: 2132 AQSRRQVEEAERLK-QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2190
Query: 510 DGNLGKELEAAQE---QLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQE 566
D + K + A++ Q A+++++ +LRL EE +HQ ++ ++ A + RQ
Sbjct: 2191 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ- 2249
Query: 567 LERCQLDFRDRTLKLE-EELHKQRDRALA-----VLTEKD-------LELEQLRSVALAS 613
R Q++ +++++ EEL K + R A +L +KD E E+++ VA +
Sbjct: 2250 --RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA 2307
Query: 614 GLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQ 673
R V + D L Q LA ++ R + E L++Q
Sbjct: 2308 A----RLSVAAQEAARLRQLAEED-LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2362
Query: 674 KHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQSREGANLEYLK 724
K + + +LQ+ + ++ EE Q +E + Q A E LK
Sbjct: 2363 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2413
Score = 85.1 bits (209), Expect = 2e-16
Identities = 127/568 (22%), Positives = 233/568 (41%), Gaps = 86/568 (15%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAE---EERA 209
+V++ L ++ Q+ L+ A + E A L DK ++ L++ + K + EE A
Sbjct: 2252 QVEEELFSVRVQMEELSKLKARIEAEN---RALILRDKDNTQRFLQEEAEKMKQVAEEAA 2308
Query: 210 RLEGELKGLQEQIAETKARLITQ--QHDRAQEQSDHALMLRELQKLLQEERTQRQDLELR 267
RL +A +A + Q + D AQ+++ ML+E + +QE + + EL
Sbjct: 2309 RLS---------VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL- 2358
Query: 268 LEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEA 327
L++ +E + A E E +QL E + + L+A R R E+ EA
Sbjct: 2359 LQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ-------RQLEMSAEA 2409
Query: 328 ARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEE--QRVAALENQISEVSELLGTYEKAKQ 385
RLK + + R ED R + Q EE +++ E E L+ T E +Q
Sbjct: 2410 ERLKLRVAEMSRAQAR---AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2466
Query: 386 KDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQV 445
+ ++L+E I +L+ E K+K+++ +LLQ+
Sbjct: 2467 QSDHDAERLREAIAELERE----------------------------KEKLQQEAKLLQL 2498
Query: 446 AARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKS 505
+ + Q + L + + + S ++ + L Q + E+ K + + + +
Sbjct: 2499 KSEEMQTVQQEQLLQETQALQQSFLSE---------KDSLLQRERFIEQEKAKLEQLFQD 2549
Query: 506 KNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQ 565
+ K L +E + Q+Q+ + +++ ++ +H+ ++ ++EL +L+Q RQ
Sbjct: 2550 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2609
Query: 566 ELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGG 625
+ E + +L E+L ++ A L E VA LP R +
Sbjct: 2610 QEEL----LAEENQRLREQLQLLEEQHRAALAHS--EEVTASQVAATKTLPNGRDAL--D 2661
Query: 626 GPGDPADTSSS-DSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQL 684
GP A+ S D L + + E L AE+L R T++ + R +V H L
Sbjct: 2662 GPAAEAEPEHSFDGLRRKVSAQRLQE-AGILSAEELQRLAQGHTTVDELARREDVR-HYL 2719
Query: 685 QDR------LLEEGERHREEVAALQSHI 706
Q R LL+ AALQ +
Sbjct: 2720 QGRSSIAGLLLKATNEKLSVYAALQRQL 2747
Score = 37.4 bits (85), Expect = 0.053
Identities = 112/475 (23%), Positives = 193/475 (40%), Gaps = 72/475 (15%)
Query: 253 LLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKS-ELQAIRD 311
L+ + Q+ RLE +AL + L + L R+V+ ++S L R
Sbjct: 884 LVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRT 943
Query: 312 EKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALA-EDQLRQQSQVEEQRVAALENQI 370
K P+ + Q L L+ H+QA L+ ED+L + E+ + +
Sbjct: 944 LK--PEEQRQALHS----LELHYQAFLRDSQDAGGFGPEDRL-----MAEREYGSCSHHY 992
Query: 371 SEVSELLGTYEKAKQKDQLAIQKLKERILQLDL-ENKTLALAASSRSPLDSH-GEESSLD 428
++ + L + + + Q I +LK+ LQL+ E +T+ R PLD E +
Sbjct: 993 QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL---RLPLDKEPARECAQR 1049
Query: 429 VNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDL-EIMPSSEAADGEKATALYYQQELKQ 487
+ + +++ L + AR S + EK+ L E P++ E L ++++
Sbjct: 1050 IAEQQKAQAEVEGLGKGVARLSA---EAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1106
Query: 488 LKEEF-ERYKMRAQVVLKSKNTKDGNLG-----KELEAAQEQLAELKEKYISLRLSCEEL 541
L + E+ K + V+ ++ ++ KE +A L EL+ SL+ +
Sbjct: 1107 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1166
Query: 542 EHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLE---EELHKQRDRALAVLTE 598
E Q Q D + EL Q++ ER Q +R +++E E + + +R AVL +
Sbjct: 1167 EAQ-QPTFDALRDELRGAQEVG----ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1221
Query: 599 KDL---ELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFL 655
D+ ELEQL GR+ S+D L LQ A + +
Sbjct: 1222 TDVRQRELEQL----------GRQLRYY---------RESADPLGAWLQDARRRQEQ--I 1260
Query: 656 YAEQLARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNI 710
A LA + LR+++ LLEE ERH E+V Q ++ I
Sbjct: 1261 QAMPLADSQAVREQLRQEQ------------ALLEEIERHGEKVEECQRFAKQYI 1303
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 97.4 bits (241), Expect = 4e-20
Identities = 178/814 (21%), Positives = 322/814 (39%), Gaps = 168/814 (20%)
Query: 22 ETQKKQLLQYQAR-LKDVVRAYKSLLKEKEALEASIKVLSVSHEADVGLAGVQLPGLTFP 80
E ++ Q+LQ + + ++ ++ + L E+E +++ V+ EA + ++ L
Sbjct: 934 EEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQ 993
Query: 81 DS--------VDDRCSTHSEDSTGTATSLDTAASLTS--TKGEFGVEDDRPARGPPPPKS 130
+S ++DR + E S+ A + A +L K E + D
Sbjct: 994 NSKFIKEKKLMEDRIA---ECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTR 1050
Query: 131 EEASWSESGVSSSSGDGPFAGGEVDKRLHQLKTQLAT----LTSSLATVTQEKS------ 180
+E ++ + + D E+ ++ +LK QLA L +LA E
Sbjct: 1051 QELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNAL 1110
Query: 181 RMEASYLADKKKMKQDLED---ASNKAEEERARLEGELKGLQEQIAETKARLITQQHDRA 237
++ A ++++D E + NKAE+++ L EL+ L+ ++ +T QQ R
Sbjct: 1111 KVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRT 1170
Query: 238 QEQSDHALMLRELQKLLQEERTQRQDLELR----LEETREALAG----RAYAAEQMEGFE 289
+ + + A + + L++ + Q QD+ R LEE E L +A + +G E
Sbjct: 1171 KREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLE 1230
Query: 290 LQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQ---EEAARLKSHFQ---AQLQQEMR 343
K+L EV+ L+ ++ + D ++QEL E RL+ ++LQ E+
Sbjct: 1231 TDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELD 1290
Query: 344 KTALAEDQLRQQSQVEEQRVAALENQISEVSELLGTYEKAK------------QKDQLAI 391
+ ++ ++ + A+LE+Q+ + ELL + K +K+ L
Sbjct: 1291 NVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQE 1350
Query: 392 QKLKERILQLDLENKTLAL----AASSRSPLDSHGEESSLDVNVLK-------------- 433
Q+ +E + +LE + LAL A + + D G SL+ K
Sbjct: 1351 QQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEE 1410
Query: 434 -----DKMEKLKRLLQVAARKSQVTLDVEK----------------LCDLEIMPSSEAAD 472
DK+EK K LQ V LD ++ L + + + + A +
Sbjct: 1411 KALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEE 1470
Query: 473 GEKATALYYQQELKQL------------KEEFERYKMRAQVVLKSKNTKDGNLGKELEAA 520
++A A ++E K L KEEFER + + ++ + ++GK +
Sbjct: 1471 RDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHEL 1530
Query: 521 QEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRD---- 576
++ L+++ +R EELE + Q +D K L Q + + ER L RD
Sbjct: 1531 EKSKRALEQQVEEMRTQLEELEDE-LQATEDAKLRLEVNMQAMKAQFER-DLQTRDEQNE 1588
Query: 577 --------RTLKLEEELHKQR-DRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGP 627
+ +LE EL +R RALAV ++K +E+
Sbjct: 1589 EKKRLLIKQVRELEAELEDERKQRALAVASKKKMEI------------------------ 1624
Query: 628 GDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQLQDR 687
D Q+ AAN+ AR EV KQ +L+ ++ Q R
Sbjct: 1625 ---------DLKDLEAQIEAANK----------ARDEVI-----KQLRKLQAQMKDYQ-R 1659
Query: 688 LLEEGERHREEVAALQSHIEKNIRDQSREGANLE 721
LEE R+E+ A EK ++ E L+
Sbjct: 1660 ELEEARASRDEIFAQSKESEKKLKSLEAEILQLQ 1693
Score = 90.5 bits (223), Expect = 5e-18
Identities = 138/627 (22%), Positives = 259/627 (41%), Gaps = 58/627 (9%)
Query: 161 LKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLE-------G 213
++ ++A +S LA +EK++ A ++ M DLE+ K E+ R LE G
Sbjct: 1004 MEDRIAECSSQLAE-EEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDG 1062
Query: 214 ELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETRE 273
E LQ+QIAE +A++ + A+++ ELQ L + L+ RE
Sbjct: 1063 ETTDLQDQIAELQAQIDELKLQLAKKEE-------ELQGALARGDDETLHKNNALKVVRE 1115
Query: 274 ALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSH 333
A A E E + + ++ +L EL+A++ E L AA+ +
Sbjct: 1116 LQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELE------DTLDTTAAQQELR 1169
Query: 334 FQAQLQQEMRKTALAEDQLRQQSQVEE--QRVAALENQISEVSELLGTYEKAKQKDQLAI 391
+ + + K AL E+ ++Q+++ QR A ++SE E ++ +K++ +
Sbjct: 1170 TKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGL 1229
Query: 392 Q-KLKERILQLDLENKTLALAASSRSPLDSHGEESSLDV--------------NVLKDKM 436
+ KE ++ + + A + R LD+ +E V + L++++
Sbjct: 1230 ETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNEL 1289
Query: 437 EKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYK 496
+ + LL+ A +K + ++ + E E L ++QL+EE K
Sbjct: 1290 DNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEE----K 1345
Query: 497 MRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQEL 556
Q + + NL K++ A Q QLA+ K+K + E LE ++ D +
Sbjct: 1346 NSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405
Query: 557 ARLQQ--LHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASG 614
RL++ L +LE+ + + L +L QR A + L +K + +QL +A
Sbjct: 1406 QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVA-SNLEKKQKKFDQL--LAEEKS 1462
Query: 615 LPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFL---YAEQLARKEVEITSLR 671
+ R + D A+ + + T+AL LA A E + Q + ++ L
Sbjct: 1463 ISARYAE-----ERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLM 1517
Query: 672 KQKHRLEVEVHQLQ--DRLLEEG-ERHREEVAALQSHIEKNIRDQSREGANLEYLKNIIY 728
K + VH+L+ R LE+ E R ++ L+ ++ + R N++ +K
Sbjct: 1518 SSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFE 1577
Query: 729 RFLTLPDSLGRQQTLTAILTILHFSPE 755
R L D ++ I + E
Sbjct: 1578 RDLQTRDEQNEEKKRLLIKQVRELEAE 1604
Score = 89.0 bits (219), Expect = 2e-17
Identities = 127/590 (21%), Positives = 250/590 (42%), Gaps = 90/590 (15%)
Query: 210 RLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLE 269
R E EL+ E++ + K + + + + + M R+ Q+LL+E+ + L+ E
Sbjct: 849 RQEEELQAKDEELLKVKEK-------QTKVEGELEEMERKHQQLLEEKNILAEQLQAETE 901
Query: 270 ETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQEL-----Q 324
EA RA A + + E L VEE + Q +++EK + +Q+L +
Sbjct: 902 LFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDE 961
Query: 325 EEAARLKSHF-----QAQLQQEMRKTALAEDQ---LRQQSQVEEQRVAALENQISEVSEL 376
EE AR K +A++++ + L EDQ ++ ++ E R+A +Q++E E
Sbjct: 962 EEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK 1021
Query: 377 LGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKM 436
K + K ++ I L+ER L E KT ++ LD + + L+ ++
Sbjct: 1022 AKNLAKIRNKQEVMISDLEER---LKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQI 1078
Query: 437 EKLKRLLQVAARKSQV----------------TLDVEKLCDLEIMPSSEAADGEKATALY 480
++LK LQ+A ++ ++ L V + +I E + EKA+
Sbjct: 1079 DELK--LQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNK 1136
Query: 481 YQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYIS-LRLSCE 539
+++ + L EE E K + L + AAQ++L +E+ ++ L+ + E
Sbjct: 1137 AEKQKRDLSEELEALKTELEDTL------------DTTAAQQELRTKREQEVAELKKALE 1184
Query: 540 ELEHQHQQEADDWKQELARLQQLHRQELER-----------------------CQLDFRD 576
E H+ + D +Q A + ++LE+ C++
Sbjct: 1185 EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQ 1244
Query: 577 RTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSS 636
+ E K+ D + L K E ++LR V LA ++ + D T
Sbjct: 1245 QVKAESEHKRKKLDAQVQELHAKVSEGDRLR-VELAEKASKLQNEL------DNVSTLLE 1297
Query: 637 DSLTQALQLA--AANEPTFFLYAEQLARKEV-EITSLRKQKHRLEVEVHQLQDRLLEEGE 693
++ + ++ A AA+ + ++L ++E + +L + +LE E + LQ++ EE E
Sbjct: 1298 EAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEE 1357
Query: 694 RHR---EEVAALQSHIEKNIRDQSREGANLEYLKNIIYRFLTLPDSLGRQ 740
+ ++V ALQS + + + +E L+ + L ++L ++
Sbjct: 1358 ARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQR 1407
Score = 87.4 bits (215), Expect = 5e-17
Identities = 120/563 (21%), Positives = 234/563 (41%), Gaps = 85/563 (15%)
Query: 19 ETIETQKKQLLQYQARLKDVVR--------------AYKSLLKEKEALEASIKVLSVSH- 63
E + +KQ+L Q++L D + A K LLK+ EAL ++ ++++
Sbjct: 1357 EARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYD 1416
Query: 64 --EADVGLAGVQLPGLTFPDSVDDRCSTHSEDSTGTATSLDTAASLTSTKGEFGVEDDRP 121
E +L LT + +++ E L A S + E DR
Sbjct: 1417 KLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQL--LAEEKSISARYAEERDR- 1473
Query: 122 ARGPPPPKSEEASWSESGVSSSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKSR 181
++ E ++ + + A E +++ QL+ + L SS V +
Sbjct: 1474 ----AEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHE 1529
Query: 182 MEASYLADKKKMK------QDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHD 235
+E S A +++++ ++LED E+ + RLE ++ ++ Q Q D
Sbjct: 1530 LEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERD-----LQTRD 1584
Query: 236 RAQEQSDHALM--LRELQKLLQEERTQR--------------QDLELRLEETREALAGRA 279
E+ L+ +REL+ L++ER QR +DLE ++E +A R
Sbjct: 1585 EQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKA---RD 1641
Query: 280 YAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQA--- 336
+Q+ + Q K RE+EE ++ I + + + +L+ L+ E +L+ +
Sbjct: 1642 EVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSER 1701
Query: 337 ----------QLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQK 386
+L E+ +A + L + + E R+A LE ++ E+ +
Sbjct: 1702 ARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEEL----------EEEQSN 1751
Query: 387 DQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVA 446
+L + ++ LQ+D N LA S+ D+ ++ LK K+++L+ ++ +
Sbjct: 1752 MELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVK-S 1810
Query: 447 ARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEF------ERYKMRAQ 500
K+ ++ K+ LE EA + A L + E K+LKE F R+ + +
Sbjct: 1811 KFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTE-KKLKEIFMQVEDERRHADQYK 1869
Query: 501 VVLKSKNTKDGNLGKELEAAQEQ 523
++ N + L ++LE A+E+
Sbjct: 1870 EQMEKANARMKQLKRQLEEAEEE 1892
Score = 45.8 bits (107), Expect = 2e-04
Identities = 70/310 (22%), Positives = 131/310 (42%), Gaps = 50/310 (16%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAE--EERAR 210
E +K+L L+ ++ L LA+ E++R A D+ + AS K+ +E+ R
Sbjct: 1677 ESEKKLKSLEAEILQLQEELAS--SERARRHAEQERDELA-DEITNSASGKSALLDEKRR 1733
Query: 211 LEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERT----------- 259
LE + L+E++ E ++ + +DR ++ + L + L L ER+
Sbjct: 1734 LEARIAQLEEELEEEQSNM-ELLNDRFRKTT---LQVDTLNAELAAERSAAQKSDNARQQ 1789
Query: 260 -QRQDLEL--RLEETREALAGRAYAA------------EQMEGFELQ----TKQLTREVE 300
+RQ+ EL +L+E A+ + A EQ+E + K + R +
Sbjct: 1790 LERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEK 1849
Query: 301 ELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEE 360
+LK + DE+ D +++++ AR+K + QL++ + A R+ + +
Sbjct: 1850 KLKEIFMQVEDERRHADQYKEQMEKANARMK-QLKRQLEEAEEEATRANASRRKLQRELD 1908
Query: 361 QRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDS 420
A E EVS L + ++ ++ + QL LE +L L+ D
Sbjct: 1909 DATEANEGLSREVSTL---KNRLRRGGPISFSSSRSGRRQLHLEGASLELS-------DD 1958
Query: 421 HGEESSLDVN 430
E + DVN
Sbjct: 1959 DTESKTSDVN 1968
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 96.3 bits (238), Expect = 1e-19
Identities = 140/607 (23%), Positives = 264/607 (43%), Gaps = 96/607 (15%)
Query: 177 QEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQEQIA---ETKARLITQQ 233
+++ R S A + M+++ E N+ E RA L E +G Q++ E + +TQ+
Sbjct: 954 EQQGRQFCSTQAALQAMEREAEQMGNELERLRAALM-ESQGQQQEERGQQEREVARLTQE 1012
Query: 234 HDRAQ-----EQSDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGF 288
RAQ E++ A + LQ L E+R + L+ L G+ ++ G
Sbjct: 1013 RGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGL 1072
Query: 289 EL----QTKQLTREVEELKSELQAIRDE-------------KNQP-DPRLQELQEEAARL 330
E + ++L + V++LK +L E + +P P+L+ L+ E ++L
Sbjct: 1073 EAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKL 1132
Query: 331 KSHFQAQLQQEMRKTALAEDQLRQQSQVE-EQRVAALENQISEVSELLGTYEKAKQKDQL 389
+ Q Q QQE + + + S+ E + + L+ Q+ E ++ LG + A Q
Sbjct: 1133 EQ--QCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQR 1190
Query: 390 AIQKLKERIL-QLDLENKTLALAASSRSPLDSHG--------EESSLDVNVLKDKME--K 438
+ + ++ E++ A A R + E S L+ VL+ + E +
Sbjct: 1191 ELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKE 1250
Query: 439 LKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMR 498
LKRL+ + KSQ + +L E S+ A E+++AL ++E++ L+EE E+ ++
Sbjct: 1251 LKRLVMAESEKSQKLEERLRLLQAE-TASNSARAAERSSAL--REEVQSLREEAEKQRVA 1307
Query: 499 AQVV---LKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLS-----------------C 538
++ + L S+ + LG+EL+A QE+ + ++ +L+L C
Sbjct: 1308 SENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLC 1367
Query: 539 EEL-------EHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDR 591
++L E +H++E + KQ L R EL R Q + + + L +++ +Q
Sbjct: 1368 QQLQAEQAAAEKRHREELEQSKQAAGGL----RAELLRAQRELGE-LIPLRQKVAEQERT 1422
Query: 592 ALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPAD----------TSSSDSLTQ 641
A + EK EQL + A GL + G G+ A+ + + Q
Sbjct: 1423 AQQLRAEKASYAEQLSMLKKAHGLLAEEN----RGLGERANLGRQFLEVELDQAREKYVQ 1478
Query: 642 ALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAA 701
L A+ T +LA + E S ++ + + + ++LEE +R +EE
Sbjct: 1479 ELAAVRADAET------RLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQK 1532
Query: 702 LQSHIEK 708
L + +E+
Sbjct: 1533 LTAQVEQ 1539
Score = 93.2 bits (230), Expect = 8e-19
Identities = 154/624 (24%), Positives = 259/624 (41%), Gaps = 105/624 (16%)
Query: 140 VSSSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQD--- 196
+S +GD F E L QL+ L LT + TQE +A + QD
Sbjct: 316 LSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKC 375
Query: 197 LEDASNKAEEERARLEGELKGLQEQIAETKARL---ITQQHDRAQEQSDHALMLRELQ-- 251
LE+ + + + ++LE L LQ+ + K + + Q QE + A +LQ
Sbjct: 376 LEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQAR 435
Query: 252 -KLLQEERTQ---------------RQDLELRLEETREALAGRAYAAEQME-GFELQTKQ 294
++L+ ER Q +Q L + + + +++ + A E++E + +
Sbjct: 436 VEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGAR 495
Query: 295 LTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQ 354
LT +V L SEL + Q D L L+++A QAQL Q +++ A LR
Sbjct: 496 LTAQVASLTSELTTLNATIQQQDQELAGLKQQA----KEKQAQLAQTLQQQEQASQGLRH 551
Query: 355 QSQVEEQRVAALENQISEVSELL-GTYEKAKQKDQLAIQKLKERILQLDLENKTLALAAS 413
Q + + E Q+ EV+E T + Q+ A ++ + + + D K L
Sbjct: 552 QVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEK 611
Query: 414 SRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVA--ARKS-QVTLDVEKLCDLEIMPSSEA 470
++ K+E L++ LQVA AR S Q ++ + E+ E
Sbjct: 612 EKAA-----------------KLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEE 654
Query: 471 ADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEK 530
TA Q E + E E ++R++ + K T+ + +E + QEQL LKE
Sbjct: 655 LQACVETARQEQHEAQAQVAELE-LQLRSE---QQKATEKERVAQEKDQLQEQLQALKE- 709
Query: 531 YISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRD 590
SL+++ LE + ++ AD +E +RC + + T L E+ ++R
Sbjct: 710 --SLKVTKGSLEEEKRRAAD------------ALEEQQRCISELKAETRSLVEQHKRER- 754
Query: 591 RALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANE 650
K+LE E+ A GL R +G A + ++ L + L A A +
Sbjct: 755 --------KELEEER----AGRKGLEARLQQLG------EAHQAETEVLRRELAEAMAAQ 796
Query: 651 PTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQ----LQDRLL---EEGERHREE----- 698
T EQL + E+ + R++ + E Q Q++L+ EE E+ R+E
Sbjct: 797 HTAESECEQLVK---EVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAK 853
Query: 699 --VAALQSHIEKNIRDQSREGANL 720
VA ++SH E I Q E A L
Sbjct: 854 EKVAGIESHSELQISRQQNELAEL 877
Score = 80.5 bits (197), Expect = 6e-15
Identities = 121/525 (23%), Positives = 220/525 (41%), Gaps = 77/525 (14%)
Query: 247 LRELQKLLQEERTQRQDLELRLEETRE-------------------ALAGRAYAAEQMEG 287
+R L+K L +ER+ R +LEL L E R+ AL AA +E
Sbjct: 216 MRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEP 275
Query: 288 FELQ-----TKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLK-------SHFQ 335
EL+ + LT + E + Q ++ EK+Q D ++ +L EE L SH Q
Sbjct: 276 KELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQ 335
Query: 336 AQLQQEMRK-----TALAEDQLRQQSQVEEQRVAALENQ--ISEVSELL-GTYEKAKQK- 386
QLQ + + + ++ L +Q+Q+E++ AAL+++ + E +E+L G + ++
Sbjct: 336 -QLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHL 394
Query: 387 DQLAIQKLKER------ILQLDLENKTLALAASSRSPLDS-----HGEESSLDVNVLKDK 435
QL +E+ +LQL+ + A A++ + L + E + +L ++
Sbjct: 395 SQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAER 454
Query: 436 MEKLKRLLQVAARKSQVTLDVEKLCDL-EIMPSSEAADGEKATA--LYYQQELKQLKEEF 492
+ Q+++ + + + L E + + A G + TA EL L
Sbjct: 455 GHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATI 514
Query: 493 ERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDW 552
++ + + K L + L+ ++ L+ + L S ++ E Q ++ A+
Sbjct: 515 QQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAE-- 572
Query: 553 KQELARLQQLHRQEL------ERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQL 606
KQE R Q H Q+L L RD LK E L K++ L +L ++ +
Sbjct: 573 KQEATR--QDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEA 630
Query: 607 RSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVE 666
R A S +R + A+ S QA A E Q+A E++
Sbjct: 631 RDSAQTSVTQAQR---------EKAELSRKVEELQACVETARQEQ--HEAQAQVAELELQ 679
Query: 667 ITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIR 711
+ S +QK + V Q +D+L E+ + +E + + +E+ R
Sbjct: 680 LRS-EQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKR 723
Score = 80.5 bits (197), Expect = 6e-15
Identities = 122/627 (19%), Positives = 263/627 (41%), Gaps = 96/627 (15%)
Query: 153 EVDKRLHQLKT----QLATLTSSLATVTQEKSRMEA------SYLADKKKMKQDLEDASN 202
++ R+ L+T Q A L + +EK ++ + S +++ + K++LE AS
Sbjct: 431 QLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQAS- 489
Query: 203 KAEEERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQ 262
+ ARL ++ L ++ A + QQ D+ EL L Q+ + ++
Sbjct: 490 --QAHGARLTAQVASLTSELTTLNATI--QQQDQ------------ELAGLKQQAKEKQA 533
Query: 263 DLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQE 322
L L++ +A G + EQ+ KQ ++++E+ + +A R + Q E
Sbjct: 534 QLAQTLQQQEQASQGLRHQVEQLSS---SLKQKEQQLKEVAEKQEATRQDHAQQLATAAE 590
Query: 323 LQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISE---------- 372
+E + R + QL+ ++ A + L+QQ QV + + + +++
Sbjct: 591 EREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSR 650
Query: 373 -VSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNV 431
V EL E A+Q+ A ++ E LQL E + A+ + + ++ +
Sbjct: 651 KVEELQACVETARQEQHEAQAQVAELELQLRSEQQ----KATEKERVAQEKDQLQEQLQA 706
Query: 432 LKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEA-----------ADGEKATALY 480
LK+ ++ K L+ R++ L+ ++ C E+ + + + E+A
Sbjct: 707 LKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKG 766
Query: 481 YQQELKQLKE----EFERYKMRAQVVLKSKNTKDG---NLGKELEAAQEQL--------- 524
+ L+QL E E E + + +++T + L KE+ A +E+
Sbjct: 767 LEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQ 826
Query: 525 --AELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLE 582
A +E+ ++L+ CE+ +QE + K+++A ++ ++ R Q +
Sbjct: 827 YGAMFQEQLMTLKEECEKA----RQELQEAKEKVAGIESHSELQISRQQNEL-------- 874
Query: 583 EELHKQRDRALAVLTEKDL-------ELEQLRSVALASGLPGRRSPVGGGGPGDPADTSS 635
ELH RAL + EK++ +L L+ A+ R G+ +T+S
Sbjct: 875 AELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETAS 934
Query: 636 SDSLTQALQLAAANEPTFF--LYAEQLARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGE 693
+ + + + A +P + Q + + ++ ++ ++ E+ +L+ L+E
Sbjct: 935 RELVKEPAR-AGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQG 993
Query: 694 RHREEVAALQSHIEKNIRDQSREGANL 720
+ +EE + + + +++ R A+L
Sbjct: 994 QQQEERGQQEREVARLTQERGRAQADL 1020
Score = 62.4 bits (150), Expect = 2e-09
Identities = 120/595 (20%), Positives = 228/595 (38%), Gaps = 56/595 (9%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASN--KAEEERAR 210
E D L L+ QL L + + A + K+ QD A + KA+ R R
Sbjct: 1159 ERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKV-QDHSKAEDEWKAQVARGR 1217
Query: 211 LEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEE 270
E E K E + ++ +Q + +S +EL++L+ E + Q LE RL
Sbjct: 1218 QEAERKNSLISSLEEEVSILNRQVLEKEGES------KELKRLVMAESEKSQKLEERLRL 1271
Query: 271 TR-EALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAAR 329
+ E + A AAE+ + + L E E+ + + +R E R +EL +E
Sbjct: 1272 LQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQE--- 1328
Query: 330 LKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQL 389
LK+ + Q+E + L Q+E AL VSELL +Q
Sbjct: 1329 LKAWQEKFFQKEQALSTL---------QLEHTSTQAL------VSELLPAKHLCQQLQ-- 1371
Query: 390 AIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARK 449
A Q E+ + +LE A L + E L + + + E+ + Q+ A K
Sbjct: 1372 AEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGEL-IPLRQKVAEQERTAQQLRAEK 1430
Query: 450 SQVTLDVEKLCDLE-IMPSSEAADGEKATA--LYYQQELKQLKEEFERYKMRAQVVLKSK 506
+ + L ++ GE+A + + EL Q + E+Y V
Sbjct: 1431 ASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAR---EKYVQELAAVRADA 1487
Query: 507 NTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQE 566
T+ + +E ++ +L + KY ++ E + Q+E ++ +L+ R++
Sbjct: 1488 ETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQ 1547
Query: 567 LERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGG 626
+ Q++ + L ++ K + + L + + E +Q A L + + +
Sbjct: 1548 TK--QVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQ-----EAQRLQAQLNEL---- 1596
Query: 627 PGDPADTSSSDSLTQALQLAAANEPTFF----LYAEQLARKEVEITSLRKQKHRLEVEVH 682
A S + + +L T + ++L + + L+K+ L E
Sbjct: 1597 ---QAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAE 1653
Query: 683 QLQDRLLEEGERHREEVAALQSHIEKNIRDQSREGANLEYLKNIIYRFLTLPDSL 737
+L L + G + +E + H+ +R + A+ + + +F D+L
Sbjct: 1654 RLGHELQQAGLKTKEAEQTCR-HLTAQVRSLEAQVAHADQQLRDLGKFQVATDAL 1707
Score = 50.1 bits (118), Expect = 8e-06
Identities = 64/283 (22%), Positives = 112/283 (39%), Gaps = 32/283 (11%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLE 212
E+D+ + +LA + + T E R S + + M E A K EER R +
Sbjct: 1468 ELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQ 1527
Query: 213 GELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLL----QEERTQRQDLELRL 268
E + L Q+ + + Q + + EL K L Q + Q+Q L+
Sbjct: 1528 EERQKLTAQVEQLEVF-----------QREQTKQVEELSKKLADSDQASKVQQQKLKAVQ 1576
Query: 269 EETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAA 328
+ E+ Q+ + Q Q + E K +++ + + + QELQE+
Sbjct: 1577 AQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLR 1636
Query: 329 RLK------SHFQAQ---LQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLGT 379
L+ +A+ L E+++ L + Q + +V +LE Q++ + L
Sbjct: 1637 SLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQL-- 1694
Query: 380 YEKAKQKDQLAIQKLKER----ILQLDLENKTLALAASSRSPL 418
+ K Q+A LK R QLDL +L L+ +PL
Sbjct: 1695 --RDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPL 1735
Score = 48.5 bits (114), Expect = 2e-05
Identities = 36/262 (13%), Positives = 118/262 (45%), Gaps = 5/262 (1%)
Query: 178 EKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHDRA 237
E + Y+ + ++ D E + + E EL+ + + K +++ ++
Sbjct: 1468 ELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQ 1527
Query: 238 QEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTR 297
+E+ + +L+ +E+ Q ++L +L ++ +A ++++ + Q + +
Sbjct: 1528 EERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQA---SKVQQQKLKAVQAQGGESQQ 1584
Query: 298 EVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQ--EMRKTALAEDQLRQQ 355
E + L+++L ++ + +Q + + + + + K+H+ A+ QQ E+++ + +QL+++
Sbjct: 1585 EAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKE 1644
Query: 356 SQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSR 415
++ L +++ + E+ + ++ L+ ++ D + + L +
Sbjct: 1645 NKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVAT 1704
Query: 416 SPLDSHGEESSLDVNVLKDKME 437
L S ++ +++ D ++
Sbjct: 1705 DALKSREPQAKPQLDLSIDSLD 1726
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 95.9 bits (237), Expect = 1e-19
Identities = 144/650 (22%), Positives = 275/650 (42%), Gaps = 92/650 (14%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLE 212
++ + L LKT+L S A + +S+ E KK ++++ + + +E R +
Sbjct: 1136 DLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHS 1195
Query: 213 GELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQ---EERTQRQDLELRLE 269
++ L EQ+ +TK + + +++ + E++ LLQ + +R+ +E +L+
Sbjct: 1196 QAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQ 1255
Query: 270 ETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAAR 329
E + + EG ++T +L +V +L+ EL + +Q D + +L ++ +
Sbjct: 1256 ELQ---------VKFNEGERVRT-ELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSA 1305
Query: 330 LKSHF---QAQLQQEMR-------KTALAEDQ---LRQQSQVEEQRVAALENQISEVSEL 376
L+S Q LQ+E R K ED+ R+Q + EE+ LE QI+ +
Sbjct: 1306 LESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQ 1365
Query: 377 LGTYEKAKQKDQLAIQKLKERI---LQLDLENKTLALAASSRSPLDSHGEESSLDVNVLK 433
+ +K K +D + + E + LQ DLE L EE
Sbjct: 1366 VADMKK-KMEDSVGCLETAEEVKRKLQKDLEG------------LSQRHEEKV----AAY 1408
Query: 434 DKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQ--QELKQLKEE 491
DK+EK K LQ V LD ++ A + EK + Q E K + +
Sbjct: 1409 DKLEKTKTRLQQELDDLLVDLDHQR---------QSACNLEKKQKKFDQLLAEEKTISAK 1459
Query: 492 FERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEEL---------- 541
+ + RA+ + K TK +L + LE A EQ AEL+ R E+L
Sbjct: 1460 YAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKS 1519
Query: 542 -------EHQHQQEADDWKQELARLQ-QLHRQELERCQLDFRDRTLKL---------EEE 584
+ +Q+ ++ K +L L+ +L E + +L+ + +K +E+
Sbjct: 1520 VHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQ 1579
Query: 585 LHKQRDRALAVLTEKDLELE---QLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQ 641
+++ + + + E + ELE + RS+A+A+ D A+ + +++ Q
Sbjct: 1580 SEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQ 1639
Query: 642 ALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRL---EVEVHQLQDRLLEEGERHREE 698
+L A + + A +E + ++ + +L E E+ QLQ+ L ER + +
Sbjct: 1640 LRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEE-LAAAERAKRQ 1698
Query: 699 VAALQSHIEKNIRDQSREGA-NLEYLKNIIYRFLTLPDSLGRQQTLTAIL 747
+ + I + S +GA LE + + R L + L +Q T ++
Sbjct: 1699 AQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELI 1748
Score = 92.0 bits (227), Expect = 2e-18
Identities = 135/602 (22%), Positives = 261/602 (43%), Gaps = 70/602 (11%)
Query: 161 LKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERA-------RLEG 213
L+ ++A T++L T +EKS+ A + M DLE+ + E++R +LEG
Sbjct: 997 LEDRIAEFTTNL-TEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEG 1055
Query: 214 ELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETRE 273
+ L +QIAE +A++ + A+++ ELQ L + + L++ RE
Sbjct: 1056 DSTDLSDQIAELQAQIAELKMQLAKKEE-------ELQAALARVEEEAAQKNMALKKIRE 1108
Query: 274 ALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSH 333
+ + E +E + ++ +L EL+A++ E L AA+ +
Sbjct: 1109 LESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELE------DTLDSTAAQQELR 1162
Query: 334 FQAQLQQEMRKTALAEDQLRQQSQVEEQR------VAALENQISEVSELLGTYEKAKQKD 387
+ + + + K L E+ ++Q++E R V L Q+ + + EKAKQ
Sbjct: 1163 SKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTL 1222
Query: 388 QLAIQKLKERILQL-----DLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLK-- 440
+ +L + L D E+K + A + L E L DK+ KL+
Sbjct: 1223 ENERGELANEVKVLLQGKGDSEHKRKKVEAQLQE-LQVKFNEGERVRTELADKVTKLQVE 1281
Query: 441 ------RLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFER 494
L Q ++ S++T D L + ++ + E E L +LKQ+++E
Sbjct: 1282 LDNVTGLLSQSDSKSSKLTKDFSAL-ESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNS 1340
Query: 495 YKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQ 554
++ + + ++K+ NL K++ Q+A++K+K + + C E + +++ ++
Sbjct: 1341 FREQLEEEEEAKH----NLEKQIATLHAQVADMKKK-MEDSVGCLETAEEVKRKL---QK 1392
Query: 555 ELARLQQLHRQ------ELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRS 608
+L L Q H + +LE+ + + L +L QR A L +K + +QL
Sbjct: 1393 DLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSA-CNLEKKQKKFDQL-- 1449
Query: 609 VALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYA--EQLARK-EV 665
+A + + + D A+ + + T+AL LA A E A E+L ++
Sbjct: 1450 LAEEKTISAKYAE-----ERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRT 1504
Query: 666 EITSLRKQKHRLEVEVHQLQ--DRLLEEG-ERHREEVAALQSHIEKNIRDQSREGANLEY 722
E+ L K + VH+L+ R LE+ E + ++ L+ ++ + R NL+
Sbjct: 1505 EMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQA 1564
Query: 723 LK 724
+K
Sbjct: 1565 MK 1566
Score = 91.7 bits (226), Expect = 2e-18
Identities = 116/491 (23%), Positives = 223/491 (45%), Gaps = 54/491 (10%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASY----LAD--KKKMKQDLEDASNKAEE 206
E ++ H L+ Q+ATL + +A + K +ME S A+ K+K+++DLE S + EE
Sbjct: 1347 EEEEAKHNLEKQIATLHAQVADM---KKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEE 1403
Query: 207 ERA---RLEGELKGLQEQIAETKARLITQQH-----DRAQEQSDHALMLRELQKLLQEER 258
+ A +LE LQ+++ + L Q+ ++ Q++ D L + E
Sbjct: 1404 KVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEE 1463
Query: 259 TQRQDLELRLEETREALAGRAY--AAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQP 316
R + E R +ET+ RA A EQ E KQ E+E+L S + ++
Sbjct: 1464 RDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHEL 1523
Query: 317 DPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSEL 376
+ + L+++ +K+ + +L+ E++ T A+ +L E + A++ Q +L
Sbjct: 1524 EKSKRALEQQVEEMKTQLE-ELEDELQATEDAKLRL-------EVNLQAMKAQFER--DL 1573
Query: 377 LGTYEKAKQKDQLAIQKLKERILQLDLENK--TLALAASSRSPLDSHGEESSLD-VNVLK 433
G E++++K + +++++E +L+ E K ++A+AA + +D E+ +D N +
Sbjct: 1574 QGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNR 1633
Query: 434 DKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEF- 492
D+ K R LQ + LD + EI+ ++A + EK + E+ QL+EE
Sbjct: 1634 DEAIKQLRKLQAQMKDCMRELDDTRASREEIL--AQAKENEKKLKSM-EAEMIQLQEELA 1690
Query: 493 --ERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEAD 550
ER K +AQ + N + A E+ L+ + L EE + + D
Sbjct: 1691 AAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELIND 1750
Query: 551 DWKQELARLQQLH----------------RQELERCQLDFRDRTLKLEEELHKQRDRALA 594
K+ ++ Q++ RQ+LER + + + ++E + + ++
Sbjct: 1751 RLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASIT 1810
Query: 595 VLTEKDLELEQ 605
L K +LE+
Sbjct: 1811 ALEAKIAQLEE 1821
Score = 83.2 bits (204), Expect = 8e-16
Identities = 108/498 (21%), Positives = 210/498 (42%), Gaps = 89/498 (17%)
Query: 154 VDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEG 213
+++++ ++KTQL L L K R+E + A K + ++DL+ ++EE++
Sbjct: 1530 LEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKK----- 1584
Query: 214 ELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETRE 273
K L Q+ E +A L ++ R+ + + +L +DLE ++ +
Sbjct: 1585 --KQLVRQVREMEAELEDERKQRSMAVAARKKLEMDL-----------KDLEAHIDSANK 1631
Query: 274 ALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSH 333
R A +Q+ + Q K RE+++ ++ + I + + + +L+ ++ E +L+
Sbjct: 1632 ---NRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEE 1688
Query: 334 FQA------QLQQEMRKTA--LAEDQLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQ 385
A Q QQE + A +A + +EE+R LE +I+++ E L E+ +
Sbjct: 1689 LAAAERAKRQAQQERDELADEIANSSGKGALALEEKR--RLEARIAQLEEEL---EEEQG 1743
Query: 386 KDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQV 445
+L +LK+ LQ+D N L L SH +++ + ++E+ + L+V
Sbjct: 1744 NTELINDRLKKANLQIDQINTDLNLER-------SHAQKN----ENARQQLERQNKELKV 1792
Query: 446 AARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKS 505
++ + T+ + KA+ + ++ QL+E+ +
Sbjct: 1793 KLQEMEGTVKSK----------------YKASITALEAKIAQLEEQLD------------ 1824
Query: 506 KNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQ 565
N KE +AA +Q+ ++K + L ++ +Q D + RL+QL RQ
Sbjct: 1825 ------NETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQ 1878
Query: 566 ------ELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRR 619
E +R R KL+ EL + A A+ E +LR L +P R
Sbjct: 1879 LEEAEEEAQRANASRR----KLQRELEDATETADAMNREVSSLKNKLRRGDLPFVVPRRM 1934
Query: 620 SPVGGGGPGDPADTSSSD 637
+ G G D +D
Sbjct: 1935 ARKGAGDGSDEEVDGKAD 1952
Score = 82.4 bits (202), Expect = 1e-15
Identities = 132/577 (22%), Positives = 239/577 (41%), Gaps = 109/577 (18%)
Query: 202 NKAEEERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQR 261
++ EEE E EL ++E+ + RL + ++Q LM +LQ LQE+
Sbjct: 841 SRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQ------LMAEKLQ--LQEQLQAE 892
Query: 262 QDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQ 321
+L EE R L + E++ L VEE + Q ++ EK + +Q
Sbjct: 893 TELCAEAEELRARLTAKKQELEEI------CHDLEARVEEEEERCQHLQAEKKKMQQNIQ 946
Query: 322 EL-----QEEAARLKSHF-----QAQLQQEMRKTALAEDQ---LRQQSQVEEQRVAALEN 368
EL +EE+AR K +A+L++ + + EDQ L ++ ++ E R+A
Sbjct: 947 ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT 1006
Query: 369 QISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLE----NKTLALAASSRSPLDSHGEE 424
++E E + K K K + I L+ER+ + + + KT + L E
Sbjct: 1007 NLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAE 1066
Query: 425 SSLDVNVLKDKMEKLKRLLQVAARK-----SQVTLDVEKLCDLE--IMPSSEAADGEKAT 477
+ LK ++ K + LQ A + +Q + ++K+ +LE I E + E+A+
Sbjct: 1067 LQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERAS 1126
Query: 478 ALYYQQELKQLKEEFERYKMR---------AQVVLKSKNTKDGNLGKE------------ 516
+++ + L EE E K AQ L+SK ++ N+ K+
Sbjct: 1127 RNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQ 1186
Query: 517 -----------LEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQEL--------- 556
+E EQL + K +L + + LE++ + A++ K L
Sbjct: 1187 IQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHK 1246
Query: 557 -----ARLQQLHRQ--ELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRS- 608
A+LQ+L + E ER + + D+ KL+ EL D +L++ D + +L
Sbjct: 1247 RKKVEAQLQELQVKFNEGERVRTELADKVTKLQVEL----DNVTGLLSQSDSKSSKLTKD 1302
Query: 609 -VALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEI 667
AL S L + + + SL+ L+ + +F EQL +E
Sbjct: 1303 FSALESQLQDTQELL-------QEENRQKLSLSTKLKQVEDEKNSF---REQLEEEE--- 1349
Query: 668 TSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQS 704
+ KH LE ++ L ++ + ++ + V L++
Sbjct: 1350 ----EAKHNLEKQIATLHAQVADMKKKMEDSVGCLET 1382
Score = 44.3 bits (103), Expect = 4e-04
Identities = 57/264 (21%), Positives = 117/264 (44%), Gaps = 58/264 (21%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNK---AEEERA 209
E +K+L ++ ++ L LA + K + + ++ ++ ++ ++S K A EE+
Sbjct: 1670 ENEKKLKSMEAEMIQLQEELAAAERAKRQAQQ----ERDELADEIANSSGKGALALEEKR 1725
Query: 210 RLEGELKGLQEQIAETKAR--LITQQHDRAQEQSDHALMLRELQK--------LLQEERT 259
RLE + L+E++ E + LI + +A Q D L++ Q+
Sbjct: 1726 RLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLER 1785
Query: 260 QRQDLELRLEETREALAGR---------AYAAEQMEGFELQTK-------QLTREVEELK 303
Q ++L+++L+E + + A A+ E + +TK Q+ R ++LK
Sbjct: 1786 QNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLK 1845
Query: 304 SELQAIRDE-------KNQPDP----------RLQELQEEAARLKSHFQAQLQQEMRKTA 346
L + DE K+Q D +L+E +EEA R + + +LQ+E+
Sbjct: 1846 DVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANAS-RRKLQRELEDAT 1904
Query: 347 LAEDQLRQQSQVEEQRVAALENQI 370
D + ++ V++L+N++
Sbjct: 1905 ETADAMNRE-------VSSLKNKL 1921
Score = 40.8 bits (94), Expect = 0.005
Identities = 69/306 (22%), Positives = 118/306 (38%), Gaps = 45/306 (14%)
Query: 26 KQLLQYQARLKDVVRAYKSLLKEKEALEASIKVLSVSHEADVGLAGVQLPGLTFPDSVDD 85
KQL + QA++KD +R +E + A K +E + ++ L + +
Sbjct: 1638 KQLRKLQAQMKDCMRELDDTRASREEILAQAK----ENEKKLKSMEAEMIQLQEELAAAE 1693
Query: 86 RCSTHSEDSTGTATSLDTAASLTSTKGEFGVEDDRPARGPPPPKSEEASWSESGVSSSSG 145
R ++ L + +S KG +E+ R EE + +
Sbjct: 1694 RAKRQAQQE---RDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELIND 1750
Query: 146 DGPFAGGEVD--------KRLHQLKT-----QLATLTSSLATVTQE-----KSRMEASYL 187
A ++D +R H K QL L QE KS+ +AS
Sbjct: 1751 RLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASIT 1810
Query: 188 ADKKKMKQDLEDASNKAEEERA------RLEGELKGLQEQIAETKARLITQQHDRAQEQS 241
A + K+ Q E N+ +E +A R E +LK + Q+ + + R Q D+A + S
Sbjct: 1811 ALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQV-DDERRNAEQYKDQADKAS 1869
Query: 242 DHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEE 301
L++L++ L+E EE + A A R ++E + REV
Sbjct: 1870 TR---LKQLKRQLEEAE----------EEAQRANASRRKLQRELEDATETADAMNREVSS 1916
Query: 302 LKSELQ 307
LK++L+
Sbjct: 1917 LKNKLR 1922
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 95.1 bits (235), Expect = 2e-19
Identities = 122/584 (20%), Positives = 252/584 (43%), Gaps = 70/584 (11%)
Query: 191 KKMKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLREL 250
+K + L K +EE + + EL+ +EQ+ + + + + ++ ++Q ++L
Sbjct: 247 RKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQL 306
Query: 251 QKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIR 310
++ +EER ++Q+ +E RE R + E E + +QL RE EE + E Q R
Sbjct: 307 RRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRR 366
Query: 311 DEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQI 370
++ + + R Q+L+ E +L+ Q + +Q++R+ E QLR++ Q+ ++ E Q+
Sbjct: 367 EQ--EEERREQQLRRE-QQLRREQQLRREQQLRR----EQQLRREQQLRREQQLRREQQL 419
Query: 371 SEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVN 430
+L E+ + + + ++ ++R+ + E + + + L +
Sbjct: 420 RREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRD 479
Query: 431 VLKD------KMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSE--------------- 469
++ K+E+ +R Q R+ Q+ + E+ + + E
Sbjct: 480 QEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLR 539
Query: 470 AADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKE 529
E+ L ++E K+L++E +++ + + +D L +E E Q++L +E
Sbjct: 540 REQEERREQLLKREEEKRLEQERREQRLKRE----QEERRDQLLKREEERRQQRLKREQE 595
Query: 530 KYISLRLSCEELEHQHQQEADDWK-----QELARLQQL---------HRQELERCQLDFR 575
+ + RL EE+E Q+E + + E R QQL +Q+L R Q + R
Sbjct: 596 ERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERR 655
Query: 576 DRTLKLEEELHKQRDRALAVLTEK-------DLELEQLRSVALASGLPGRRSPVGGGGPG 628
++ LK EEE + R E+ + E EQ R + S +P + +
Sbjct: 656 EQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARE-RIKSRIPKWQWQLESEADA 714
Query: 629 DPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQK-HRLEVEVHQLQD- 686
+ S + + E E+ R+E E+ +++ HR + E Q +D
Sbjct: 715 RQSKVYSRPRKQEGQRRRQEQE-------EKRRRRESELQWQEEERAHRQQQEEEQRRDF 767
Query: 687 ----RLLEEGERHREEVAA---LQSHIEKNIRDQSREGANLEYL 723
+ E+ ER R+ ++A L+ E+ +R + R+ +L
Sbjct: 768 TWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFL 811
Score = 87.4 bits (215), Expect = 5e-17
Identities = 120/563 (21%), Positives = 237/563 (42%), Gaps = 45/563 (7%)
Query: 177 QEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHDR 236
Q++ R E ++++ ++ L + E+ R E LK QE E + +L+ ++ +R
Sbjct: 529 QQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQE---ERRDQLLKREEER 585
Query: 237 AQEQSDHALMLRELQKLLQEERTQRQDLE-LRLEETREALAGRAYAAEQMEGFELQTKQL 295
Q++ L+ Q+ E+R +R+++E L EE RE R E E + + L
Sbjct: 586 RQQR------LKREQEERLEQRLKREEVERLEQEERREQRLKREEPEE-----ERRQQLL 634
Query: 296 TREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQ 355
E +E + + Q R+++ + + RL+ +EE RL+ + + ++E R+ LAE++ Q
Sbjct: 635 KSEEQEERRQQQLRREQQERREQRLKR-EEEEERLEQRLKREHEEERREQELAEEEQEQA 693
Query: 356 SQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSR 415
+ + R+ + Q+ ++ + ++ + Q ++ +E+ + L R
Sbjct: 694 RERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEER 753
Query: 416 SPLDSHGEESSLDVN---VLKDKMEKLKRLLQV-----AARKSQVTLDVEKLCDLEIMPS 467
+ EE D ++K E+ ++ L R+ Q+ + + + +P
Sbjct: 754 AHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPE 813
Query: 468 SEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAEL 527
E + + ++EL+ L+EE E+ + R + + +E +QEQ +
Sbjct: 814 EEEKEQRRRQRREREKELQFLEEE-EQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQ 872
Query: 528 KEKYISLRLSCEELEHQHQQEADDWKQELARLQQ---------LHRQELERCQLDFRDRT 578
K ++ +L E +H A QE R +Q L R+E E+ + ++R
Sbjct: 873 KWRW---QLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQ 929
Query: 579 LKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDS 638
+ EE+L ++ ++ L EK E+ R L + + G P
Sbjct: 930 YREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKK 989
Query: 639 LTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQL-----QDRLLEEGE 693
+ +L E L E+ R+ E ++K L+ E QL + R L+E E
Sbjct: 990 YREEEELQQEEEQ--LLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERE 1047
Query: 694 RHREEVAALQSHIEKNIRDQSRE 716
R E LQ E+ + + RE
Sbjct: 1048 RQYREEEELQQE-EEQLLGEERE 1069
Score = 79.0 bits (193), Expect = 2e-14
Identities = 129/576 (22%), Positives = 240/576 (41%), Gaps = 58/576 (10%)
Query: 177 QEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHDR 236
QE+ R A +K ++ + + +EE R E + +E+ AE + + H+
Sbjct: 142 QEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHET 201
Query: 237 AQEQSDHALMLRELQKL-------LQEERTQRQDLELRLEETREALAGRAYAAEQMEGFE 289
+ + L REL +L Q++R +RQD + EE +E ++ E +
Sbjct: 202 EEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQ 261
Query: 290 LQTKQLTREVEE-----LKSELQAIRDEKNQPDPRLQEL-QEEAARLKSHFQAQLQQEMR 343
+ Q RE++E K E Q +R E+ + + + Q L +E+ R K + + QQE R
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER 321
Query: 344 K---------TALAEDQL-RQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQK 393
+ E QL R+Q + EQ++ + + +L E+ +++ QL ++
Sbjct: 322 REQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQ 381
Query: 394 LKERILQLDLE-----NKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAAR 448
R QL E + L R E+ L+ + E+ + +
Sbjct: 382 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQE 441
Query: 449 KSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERY-KMRAQVVLKSKN 507
+ + L E+ + + E + + Q + Q +E ER+ K+ + + +
Sbjct: 442 RREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQE 501
Query: 508 TKDGNLGKELEAAQEQ--LAELKEKYISLRLSCEELEHQHQQEADDW---KQELARLQQL 562
++ L +E E +EQ + +E+ + RL E+ + Q+E + ++E RL+Q
Sbjct: 502 RREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQE 561
Query: 563 HR-QELERCQLDFRDRTLKLEEELHKQR-DRALAVLTEKDLELEQLRSVALASGLPGRRS 620
R Q L+R Q + RD+ LK EEE +QR R E+ L+ E++ + R
Sbjct: 562 RREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLK 621
Query: 621 PVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVE 680
+ + Q L+ E +QL R++ E R+Q+ + E E
Sbjct: 622 ----------REEPEEERRQQLLKSEEQEERR----QQQLRREQQE---RREQRLKREEE 664
Query: 681 VHQLQDRLLEEGERHREEVAALQSHIEKNIRDQSRE 716
+L+ RL E E R E + + ++Q+RE
Sbjct: 665 EERLEQRLKREHEEERRE-----QELAEEEQEQARE 695
Score = 75.1 bits (183), Expect = 2e-13
Identities = 135/587 (22%), Positives = 246/587 (41%), Gaps = 74/587 (12%)
Query: 177 QEKSRMEASYLADKKK--MKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQH 234
QE+ R E L ++++ +++ E + +E + R E +L+ +EQ+ + +Q
Sbjct: 896 QEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE 955
Query: 235 DRAQEQSDHALMLRELQ---------------KLLQEERTQRQDLELRLEETREALAGRA 279
Q + D L +E Q K +EE +Q+ E L E RE +
Sbjct: 956 RERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQE 1015
Query: 280 YAAEQMEGFELQ--TKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQ 337
+ + + ELQ +QL RE E K LQ R+ + + + LQ QEE L + +
Sbjct: 1016 WERQYRKKDELQQEEEQLLREERE-KRRLQE-RERQYREEEELQ--QEEEQLLGEERETR 1071
Query: 338 LQQEMRKTALAEDQLRQQ------SQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAI 391
+QE+ + E++L+Q+ + E++R E Q E EL +Q+++ +
Sbjct: 1072 RRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEEL-------QQEEEQLL 1124
Query: 392 QKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKSQ 451
++ +E+ + +LE + R + EE L L+++ EK +R Q R+ +
Sbjct: 1125 REEREKRRRQELERQ-------YREEEEVQQEEEQL----LREEPEKRRR--QELERQYR 1171
Query: 452 VTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLK------EEFERYKMRAQVVLKS 505
++++ + + E E+ ++EL++ K +E +R ++ Q +
Sbjct: 1172 EEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEK 1231
Query: 506 KNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEH-QHQQEADDWKQELARLQQLHR 564
+N N EQ +L++ + R S ++L+H +Q+ D +QE R QQ R
Sbjct: 1232 ENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDR 1291
Query: 565 QELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDL---ELEQLRSVALASGLPGRRSP 621
E QL+ + E++ K+RDR EK L E E+ R
Sbjct: 1292 HFPEEEQLE------REEQKEAKRRDRKSQ--EEKQLLREEREEKRRRQETDRKFREEEQ 1343
Query: 622 VGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRL---- 677
+ P D + +L + FL EQ R++ K++ +L
Sbjct: 1344 LLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQE 1403
Query: 678 -EVEVHQLQDRLLEEGERH--REEVAALQSHIEKNIRDQSREGANLE 721
E ++ Q +DR E E+ R+E E+ +R Q RE LE
Sbjct: 1404 REQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLE 1450
Score = 72.8 bits (177), Expect = 1e-12
Identities = 132/574 (22%), Positives = 233/574 (40%), Gaps = 102/574 (17%)
Query: 179 KSRMEASYLADKKKMKQDLEDASNK-AEEERARLEGELKGLQEQIAETK----------- 226
KS+ E L ++++ K+ ++ K EEE+ E E + L+ Q + K
Sbjct: 1313 KSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQ 1372
Query: 227 ARLITQQHDRAQEQSDHALMLRELQKLLQEERTQ--RQDLELRLEETREALAGRAYAAEQ 284
R ++ R + Q L+E Q+L +ER Q RQD + + E + L+ + E+
Sbjct: 1373 GRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQ----ER 1428
Query: 285 MEGFELQTKQLTREVEELK--SELQAIRDEKNQPDPRLQELQEEAARLKSHFQA------ 336
F + +Q+ R+ E K E Q +R E+++ ++L +E + H Q
Sbjct: 1429 DRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFL 1488
Query: 337 ----QLQQEMRKTALAEDQLRQQSQV-----EEQRVAALENQISEVSE--LLGTYEKAKQ 385
QL+++ R E +LR Q EEQ++ + Q + E L E+ +Q
Sbjct: 1489 EEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQ 1548
Query: 386 KDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQV 445
+ Q +K +E QL E + L SR D V + + + ++ Q+
Sbjct: 1549 RRQDRDRKFREEE-QLRQEREEQQL---SRQERDRKFRLEEQKVRRQEQERKFMEDEQQL 1604
Query: 446 AARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQ-ELKQLKEEFE-RYKMRAQVVL 503
++ Q L E+ D + + + L+ Q+ + K L+EE + R + R Q +
Sbjct: 1605 RRQEGQQQLRQER--DRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLR 1662
Query: 504 KSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLH 563
++ K + L+ +EQ +E+ R ++L Q ++ ++ L QQL
Sbjct: 1663 HDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERE-----RKFLQEEQQLR 1717
Query: 564 RQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVG 623
RQELER + + E+E ++++R K LE EQLR P R
Sbjct: 1718 RQELERKFREEEQLRQETEQEQLRRQER-----YRKILEEEQLR--------PEREE--- 1761
Query: 624 GGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQ 683
+QL R+E + +++ R E E Q
Sbjct: 1762 ----------------------------------QQLRRQERDRKFREEEQLRQEREEQQ 1787
Query: 684 LQDRLLEEGERHREEVAALQSHIEKNIRDQSREG 717
L+ + E + REE Q E+ +R Q R+G
Sbjct: 1788 LRSQ--ESDRKFREEEQLRQEREEQQLRPQQRDG 1819
Score = 72.4 bits (176), Expect = 1e-12
Identities = 102/443 (23%), Positives = 199/443 (44%), Gaps = 69/443 (15%)
Query: 155 DKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGE 214
++R QL+ + QE+ R E ++++++ E+ + E++ R E +
Sbjct: 333 ERREQQLRREQEERREQQLRREQEEERRE-------QQLRREQEE---ERREQQLRREQQ 382
Query: 215 LKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREA 274
L+ +EQ + +L +Q R ++Q LR Q+L +E++ +R+ E R E+ E
Sbjct: 383 LR--REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQ 440
Query: 275 LAGRAYAAEQMEGFELQTKQLTREVEE----LKSELQAIRDEKNQPDPRLQELQEEAAR- 329
E + ++L RE EE LK E + R E+ + +L+ QEE R
Sbjct: 441 --------------ERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRE 486
Query: 330 --LKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKD 387
LK + + +Q+ R+ E QLR++ EE+R L+ Q E E L +++Q+
Sbjct: 487 RWLKLEEEERREQQERR----EQQLRREQ--EERREQRLKRQ--EEEERLQQRLRSEQQL 538
Query: 388 QLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAA 447
+ ++ +E++L+ + E + E+ + + +++ E+ +LL+
Sbjct: 539 RREQEERREQLLKREEEKRL---------------EQERREQRLKREQEERRDQLLKREE 583
Query: 448 RKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKN 507
+ Q L E+ LE + E+ L ++ +Q + E + R Q +LKS+
Sbjct: 584 ERRQQRLKREQEERLE-----QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSE- 637
Query: 508 TKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQEL 567
++ E Q+QL +++ RL EE E + +Q +E R Q+L +E
Sbjct: 638 -------EQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQ 690
Query: 568 ERCQLDFRDRTLKLEEELHKQRD 590
E+ + + R K + +L + D
Sbjct: 691 EQARERIKSRIPKWQWQLESEAD 713
Score = 70.1 bits (170), Expect = 7e-12
Identities = 107/518 (20%), Positives = 225/518 (43%), Gaps = 34/518 (6%)
Query: 197 LEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQE 256
L A+ EE+RAR +G+ LQ++ E R + + +E+ R QK ++
Sbjct: 89 LGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQ----RRRQKRQEQ 144
Query: 257 ERTQRQDLELRLEETREALAGRAYAAEQM--EGFELQTKQLTREVEELKSELQAIRDEKN 314
ER + E ++ R R E++ + E Q ++ R EE +LQ+ + +
Sbjct: 145 ERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEE---QLQSCKGHET 201
Query: 315 QPDPRLQEL-QEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEE--QRVAALENQIS 371
+ P ++L + E L+ + + QQ+ R+ +D++ Q+ + +E +R L +
Sbjct: 202 EEFPDEEQLRRRELLELRRKGREEKQQQRRE---RQDRVFQEEEEKEWRKRETVLRKEEE 258
Query: 372 EVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNV 431
++ E ++ Q+++ ++KL+ + L+ + + + R +E
Sbjct: 259 KLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQ 318
Query: 432 LKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEE 491
+ + ++ +R Q R+ Q+ + E+ + ++ E E+ ++E ++ +
Sbjct: 319 EERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLR 378
Query: 492 FERYKMRAQVVLKSKN-TKDGNLGKELEAAQEQLAELKE---KYISLRLSCEELEHQHQQ 547
E+ R Q + + + ++ L +E + +EQ ++ + LR EE H+ +
Sbjct: 379 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKH 438
Query: 548 EADDWKQELARLQQLHR------QELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDL 601
E + +Q L R Q+ R +E ER + + R + LK ++E ++R+R L + E+
Sbjct: 439 EQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQE-EERRERWLKLEEEERR 497
Query: 602 ELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLA 661
E ++ R L RR + L QL E EQL
Sbjct: 498 EQQERREQQLRREQEERREQ---RLKRQEEEERLQQRLRSEQQLRREQEER----REQLL 550
Query: 662 RKEVE-ITSLRKQKHRLEVEVHQLQDRLLEEGERHREE 698
++E E +++ RL+ E + +D+LL+ E R++
Sbjct: 551 KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQ 588
Score = 70.1 bits (170), Expect = 7e-12
Identities = 116/555 (20%), Positives = 229/555 (41%), Gaps = 61/555 (10%)
Query: 177 QEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQE----QIAETKARLITQ 232
QE+ R +L +++++++ + EE++ R + + L++ + E + +L Q
Sbjct: 1370 QEQGR---KFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQ 1426
Query: 233 QHDRAQEQSDHALMLRELQ-KLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQ 291
+ DR + + + +E + K L+EE+ RQ+ + E + L R E Q
Sbjct: 1427 ERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQERE---------EQQ 1477
Query: 292 TKQLTREVEELKSELQAIRDEKNQP--DPRLQELQEEAARLKSHFQAQLQQEMRKTALAE 349
+ R+ + L+ E Q R E+++ + L+ + E L+ Q QQ RK E
Sbjct: 1478 LHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEE 1537
Query: 350 DQLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLA 409
QLR+Q + +++R + + E +L + +++ QL+ Q ER + LE + +
Sbjct: 1538 QQLRRQERGQQRRQDR-DRKFREEEQL----RQEREEQQLSRQ---ERDRKFRLEEQKVR 1589
Query: 410 LAASSRSPLDSHGE--ESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPS 467
R ++ + + +++ K + Q+ + + L ++ +
Sbjct: 1590 RQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEE 1649
Query: 468 SEAADGEKATALYYQQELK-----QLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQE 522
+ E+ L + ++ K QL +E E ++R Q +D +E + +
Sbjct: 1650 PQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQ-------ERDRKFREEEQQLRR 1702
Query: 523 QLAELKEKYISLRLSCEELEHQHQQEAD---DWKQELARLQQLHRQELERCQL------- 572
Q E K +L +ELE + ++E + +QE R Q+ +R+ LE QL
Sbjct: 1703 QERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQ 1762
Query: 573 ----DFRDRTLKLEEELHKQRDRALAVLTEKD---LELEQLRSVALASGLPGRRSPVGGG 625
RDR + EE+L ++R+ E D E EQLR L ++
Sbjct: 1763 QLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYR 1822
Query: 626 GPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQLQ 685
+ + + + F E+ R+E E+ +QK R E E +
Sbjct: 1823 WEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLRE 1882
Query: 686 D---RLLEEGERHRE 697
+ R +E +RHR+
Sbjct: 1883 EHIRRQQKEEQRHRQ 1897
Score = 65.5 bits (158), Expect = 2e-10
Identities = 133/606 (21%), Positives = 237/606 (39%), Gaps = 90/606 (14%)
Query: 177 QEKSRMEASYLADKKKMKQDLEDASN--KAEEERARLEGELKGLQEQIAETKARLITQQH 234
+++ + E L +++ K+ L++ + EEE + E +L G +E+ + L Q
Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLG-EERETRRRQELERQYR 1081
Query: 235 DRAQEQSDHALMLR---------ELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQM 285
+ Q + +LR E ++ +EE +Q+ E L E RE + +
Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR 1141
Query: 286 EGFELQ--TKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMR 343
E E+Q +QL RE E + + R + + +ELQ+E +L Q + +QE
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYREE-----EELQQEEEQLLREEQEKRRQERE 1196
Query: 344 KTALAEDQLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDL 403
+ E++L++Q + + R E+Q S++ ++ +D K +E L
Sbjct: 1197 RQYREEEELQRQKRKQRYRD---EDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQL 1253
Query: 404 ENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLE 463
E+ L S + GE+ D + + ++ R + + K D +
Sbjct: 1254 EDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRK 1313
Query: 464 IMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQ 523
+ E+ Q+ ++ +EE + + R + L+ + +D +E QEQ
Sbjct: 1314 SQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLR-RQERDRKFREEELRHQEQ 1372
Query: 524 LAELKEKYISLR--------------LSCEELEHQHQQEAD----DWKQELARL------ 559
+ E+ LR L C+E E Q +Q+ D + +Q+L+R
Sbjct: 1373 GRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKF 1432
Query: 560 ----QQLHRQELERCQLD-------FRDRTLKLEEELHKQRDRALAVLTEKD---LELEQ 605
QQ+ RQE ER L+ R R + EE+L ++R+ E+D LE EQ
Sbjct: 1433 REEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQ 1492
Query: 606 ----------LRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFL 655
R L S P R+ L + QL FL
Sbjct: 1493 QLRRQERDRKFREQELRSQEPERK------------------FLEEEQQLHRQQRQRKFL 1534
Query: 656 YAEQLARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQSR 715
EQ R++ R+ + R E QL+ EE + R+E E+ +R Q +
Sbjct: 1535 QEEQQLRRQERGQQRRQDRDRKFREEEQLRQE-REEQQLSRQERDRKFRLEEQKVRRQEQ 1593
Query: 716 EGANLE 721
E +E
Sbjct: 1594 ERKFME 1599
Score = 64.7 bits (156), Expect = 3e-10
Identities = 111/494 (22%), Positives = 205/494 (41%), Gaps = 50/494 (10%)
Query: 137 ESGVSSSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQD 196
E +S D F E R + + + L K R E L ++++ +
Sbjct: 1420 EQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLH 1479
Query: 197 LEDASNKAEEERARLEGELKGL----QEQIAETKARLITQQHDRAQEQSDHALMLRELQK 252
++ K EE +L + + QE ++ R ++ + Q L+E Q+
Sbjct: 1480 RQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQ 1539
Query: 253 LLQEERTQ----------RQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEEL 302
L ++ER Q R++ +LR E + L+ + E+ F L+ +++ R+ +E
Sbjct: 1540 LRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQ----ERDRKFRLEEQKVRRQEQER 1595
Query: 303 K---SELQAIRDEKNQP--DPRLQELQEEAARLKSHFQAQL--QQEMRKTALAEDQLRQQ 355
K E Q R E Q R ++ +E+ L+ + QL Q+ RK E QLR+Q
Sbjct: 1596 KFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQ 1655
Query: 356 SQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSR 415
+ E+Q + + E +LL E+ + + Q +K +E QL + + +
Sbjct: 1656 ER-EQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQ 1714
Query: 416 SPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEK 475
E + L+ + E+ + Q RK L+ E+L P E +
Sbjct: 1715 QLRRQELERKFREEEQLRQETEQEQLRRQERYRK---ILEEEQL-----RPEREEQQLRR 1766
Query: 476 ATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQ--EQLAELKEKYIS 533
+E +QL++E E ++R+Q + K ++ L +E E Q Q + K ++
Sbjct: 1767 QERDRKFREEEQLRQEREEQQLRSQESDR-KFREEEQLRQEREEQQLRPQQRDGKYRWEE 1825
Query: 534 LRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRAL 593
+L EE E + +QE D ++ +Q QE R + ++ L EEE ++++R
Sbjct: 1826 EQLQLEEQEQRLRQERD---RQYRAEEQFATQEKSRRE----EQELWQEEEQKRRQER-- 1876
Query: 594 AVLTEKDLELEQLR 607
E+ L E +R
Sbjct: 1877 ----ERKLREEHIR 1886
Score = 60.8 bits (146), Expect = 5e-09
Identities = 105/496 (21%), Positives = 205/496 (41%), Gaps = 51/496 (10%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRM-----EASYLADKKKMKQDLEDASNKAEEE 207
E ++RL + + + L QE+ + + + +++++ + D + EE+
Sbjct: 1378 EEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQ 1437
Query: 208 RARL-EGELKGLQE--QIAETKARLITQQHDRAQEQSDHALMLREL-QKLLQEE---RTQ 260
+ R E E K L+E Q+ + + R ++ QE+ + L +E +K L+EE R Q
Sbjct: 1438 QVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQ 1497
Query: 261 RQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQP---- 316
+D + R +E R R + E E Q + R+ + L+ E Q R E+ Q
Sbjct: 1498 ERDRKFREQELRSQEPERKFLEE-----EQQLHRQQRQRKFLQEEQQLRRQERGQQRRQD 1552
Query: 317 -DPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQV-----EEQRVAALENQ- 369
D + +E +E+ + + Q Q+ RK L E ++R+Q Q +EQ++ E Q
Sbjct: 1553 RDRKFRE-EEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQ 1611
Query: 370 ---------ISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAAS------S 414
E +LL E+ + Q +K E QL + + L
Sbjct: 1612 QLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFRE 1671
Query: 415 RSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEI----MPSSEA 470
L GEE L K + ++ L+ R+ + + ++L E+ +
Sbjct: 1672 EEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQL 1731
Query: 471 ADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEK 530
+ L Q+ +++ EE + R + L+ + +D +E + QE+ +
Sbjct: 1732 RQETEQEQLRRQERYRKILEEEQLRPEREEQQLR-RQERDRKFREEEQLRQEREEQQLRS 1790
Query: 531 YISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRD 590
S R EE Q +QE ++ + + +R E E+ QL+ +++ L+ E + + +
Sbjct: 1791 QESDRKFREE--EQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAE 1848
Query: 591 RALAVLTEKDLELEQL 606
A + E ++L
Sbjct: 1849 EQFATQEKSRREEQEL 1864
Score = 59.3 bits (142), Expect = 1e-08
Identities = 139/650 (21%), Positives = 258/650 (39%), Gaps = 94/650 (14%)
Query: 156 KRLHQLKTQLATLTSSLATVTQEKSRMEAS-YLADKKKMKQDLEDASNKAEEERARLEGE 214
+R ++ + +L L QEK R E +++++++ + E++R+ L+ +
Sbjct: 1167 ERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQ 1226
Query: 215 LKGLQEQ-IAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETRE 273
+ +E + + K +++++ ++ D L R+ Q+ LQ ++Q+ + E R
Sbjct: 1227 WEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRW 1286
Query: 274 ALAGRAYAAEQMEGFELQT------------KQLTREVEELKSELQAIRDEKNQPDPRLQ 321
R + E+ E Q KQL RE R+EK + +
Sbjct: 1287 QQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREE----------REEKRRRQETDR 1336
Query: 322 ELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQ-----VEEQRVAALENQISEVSE- 375
+ +EE L+ + L+++ R E++LR Q Q EEQR+ E + + E
Sbjct: 1337 KFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEE 1396
Query: 376 -LLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKD 434
L E+ +Q Q +K +E QL SR D E V +
Sbjct: 1397 QQLRCQEREQQLRQDRDRKFREEEQQL------------SRQERDRKFREEEQQVRRQER 1444
Query: 435 KMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFER 494
+ + L+ Q+ + + + E+L + E + + +E +QL+ +
Sbjct: 1445 ERKFLEEEQQLRQERHRKFREEEQL----LQEREEQQLHRQERDRKFLEEEQQLRRQERD 1500
Query: 495 YKMRAQVVLKSKNTKDGNLGKE--LEAAQEQLAELKEKYISLRLSCEELEHQHQQEAD-D 551
K R Q L+S+ + L +E L Q Q L+E+ +L +E Q +Q+ D
Sbjct: 1501 RKFREQ-ELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQ---QLRRQERGQQRRQDRDRK 1556
Query: 552 WKQELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVAL 611
+++E Q+ Q+L R + RDR +LEE+ +++++ + ++ +QLR
Sbjct: 1557 FREEEQLRQEREEQQLSRQE---RDRKFRLEEQKVRRQEQERKFMEDE----QQLRRQEG 1609
Query: 612 ASGLPGRRSPVGGGGPGDPADTSSSDSLTQ---ALQLAAANEPTFFLYAEQLARKEVEIT 668
L R + L Q QL FL E R++
Sbjct: 1610 QQQLRQERD----------RKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQ 1659
Query: 669 SLRKQKHRLEVEVHQLQDRLLEEGER---HREEVAALQSHIEKNIRDQSREGANLEYLKN 725
LR + R E +++LL+EGE R+E E+ +R Q RE L+ +
Sbjct: 1660 QLRHDRDRKFRE----EEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQ 1715
Query: 726 IIYRFL-------------TLPDSLGRQQTLTAILTILHFSPEEKQVIMR 762
+ + L T + L RQ+ IL PE ++ +R
Sbjct: 1716 LRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLR 1765
Score = 45.1 bits (105), Expect = 3e-04
Identities = 47/175 (26%), Positives = 86/175 (49%), Gaps = 20/175 (11%)
Query: 205 EEERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDL 264
EEE+ R E E + L+ Q + K R ++ QE+ + L +E + +EE RQ+
Sbjct: 1751 EEEQLRPEREEQQLRRQERDRKFR---EEEQLRQEREEQQLRSQESDRKFREEEQLRQER 1807
Query: 265 ELRLEETREALAGRAYAAEQMEGFELQTKQLTREVE-ELKSELQAIRDEKNQPDPRLQEL 323
E + ++ + EQ++ E Q ++L +E + + ++E Q EK++ + QEL
Sbjct: 1808 EEQQLRPQQRDGKYRWEEEQLQ-LEEQEQRLRQERDRQYRAEEQFATQEKSRREE--QEL 1864
Query: 324 QEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLG 378
+E + Q +++ R+ L E+ +R+Q Q EEQR Q+ E+ G
Sbjct: 1865 WQE--------EEQKRRQERERKLREEHIRRQ-QKEEQR----HRQVGEIKSQEG 1906
Score = 32.0 bits (71), Expect = 2.2
Identities = 30/113 (26%), Positives = 52/113 (46%), Gaps = 9/113 (7%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLE 212
E ++RL Q + + AT QEKSR E L +++ K+ ++ K EE R +
Sbjct: 1832 EQEQRLRQERDRQYRAEEQFAT--QEKSRREEQELWQEEEQKR-RQERERKLREEHIRRQ 1888
Query: 213 GELKGLQEQIAETKARLITQQHDRAQEQSDH-----ALMLRELQKLLQEERTQ 260
+ + Q+ E K++ + H R E H + L + +QE+R+Q
Sbjct: 1889 QKEEQRHRQVGEIKSQ-EGKGHGRLLEPGTHQFASVPVRSSPLYEYIQEQRSQ 1940
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 94.4 bits (233), Expect = 4e-19
Identities = 155/622 (24%), Positives = 264/622 (42%), Gaps = 80/622 (12%)
Query: 129 KSEEASWSESGVSSSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLA 188
++EEAS +S S+ + A ++D L++L QL S+L Q ++ EA+
Sbjct: 728 RAEEASLQDSLSKLSALNESLAQDKLD--LNRLVAQLEEEKSALQG-RQRQAEQEATVAR 784
Query: 189 DKKKMKQDLEDASNKAEEERAR--LEGELKGLQEQIAETKARLITQQHDRAQEQSDHALM 246
++++ ++L + E+E AR LEG L+ ++ + +L T +H+R+Q Q A +
Sbjct: 785 EEQERLEEL-----RLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQL 839
Query: 247 LRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSEL 306
R+L QE R++ + ++E A + A++ G +Q RE L E
Sbjct: 840 SRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEA 899
Query: 307 QAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAAL 366
+R EK + L E+Q + A+L++ + QL+ E + LA++ L + +A L
Sbjct: 900 TRLRLEKEALEGSLFEVQRQLAQLEAR-REQLEAEGQALLLAKETLTGE-------LAGL 951
Query: 367 ENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESS 426
QI + T EKA +L QKL +Q + E + AS R +H E
Sbjct: 952 RQQI------IATQEKASLDKELMAQKL----VQAEREAQ-----ASLREQRAAHEE--- 993
Query: 427 LDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELK 486
D+ L+ + E R L+ + Q L E+ L + + + E+ AL +++
Sbjct: 994 -DLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEG 1052
Query: 487 QLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQ 546
L E E+ Q L K ++ L ++L + LA ISL + ++ + Q +
Sbjct: 1053 LLLAESEK-----QQALSLKESEKTALSEKLMGTRHSLAT-----ISLEMERQKRDAQSR 1102
Query: 547 QEAD------------DWKQELARLQQLHRQELERCQLDF------RDRTLKLEEELHKQ 588
QE D D + + H QE+ R Q RD L+ EEL Q
Sbjct: 1103 QEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQ 1162
Query: 589 -------RD---RALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDS 638
RD R L K E ++ R V RRS +G G A S++
Sbjct: 1163 LRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRS-LGEGAKEREALRRSNEE 1221
Query: 639 LTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREE 698
L A++ A + + L E KE ++ L + + + E +L+ L+E ER R E
Sbjct: 1222 LRSAVKKAESERISLKLANED---KEQKLALLEEARTAVGKEAGELRTG-LQEVERSRLE 1277
Query: 699 VAALQSHIEKNIRDQSREGANL 720
+ + ++ E L
Sbjct: 1278 ARRELQELRRQMKMLDSENTRL 1299
Score = 87.4 bits (215), Expect = 5e-17
Identities = 175/810 (21%), Positives = 320/810 (39%), Gaps = 139/810 (17%)
Query: 15 KDLLETIETQKKQLLQYQARLKDVVRAYKSLLKEKEALEASIKVLSVSHEADVGLAGVQL 74
KDL E +E + LQ QA L+ ++ E L+ +++ L+ + +D +GVQL
Sbjct: 421 KDLTEKLEALESLRLQEQAALET---------EDGEGLQQTLRDLAQAVLSD-SESGVQL 470
Query: 75 PGLTFPDSVDDRCSTHSEDSTGTATSLDTAASLTSTKGEFGVEDDRPARGPPPPKSE--- 131
G ++ S G+ L + + + P RGP P S+
Sbjct: 471 SG----------SERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSST 520
Query: 132 ----------------------EASWSESG-VSSSSGDGPFAGGEVDKRLHQLKTQLATL 168
EAS G + D ++++L +L+ +
Sbjct: 521 LALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGA 580
Query: 169 TSSLATVTQEKSRMEAS---YLADKKKMKQDLEDASNKAEEERARLEGELKGLQEQIAET 225
+ +E R+ ++ +K + L+ A +AEE R E +L+ QE++
Sbjct: 581 MQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQERE-KLQAAQEELRRQ 639
Query: 226 KARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREAL---------- 275
+ RL +Q D Q+ + L + L++ +R L L E REAL
Sbjct: 640 RDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDML 699
Query: 276 -AGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLK--- 331
A +A AE + E +L + +L++E +++D + +L L E A+ K
Sbjct: 700 QAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLS----KLSALNESLAQDKLDL 755
Query: 332 SHFQAQLQQEMRKTALAEDQLRQQSQV---EEQRV--AALENQISE--VSELLGTYEKAK 384
+ AQL++E + Q Q++ V E++R+ LE +++ + L E+A+
Sbjct: 756 NRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQ 815
Query: 385 QKDQLAIQKLKERILQLDLENKTLALAASSR-SPLDSHGEESSLDVNVLKDKMEKLKRLL 443
+ + + L+ QL + L+ S R L+ E+ V L+ + + L
Sbjct: 816 EALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALA 875
Query: 444 Q---------VAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFER 494
+ VAA + TL E + EA +G + Q++L QL+ E+
Sbjct: 876 KEHAGLAVQLVAAEREGRTLSEEA---TRLRLEKEALEG---SLFEVQRQLAQLEARREQ 929
Query: 495 YKMRAQVVLKSKNTKDGNLG----------------------KELEAAQEQLAELKEKYI 532
+ Q +L +K T G L K ++A +E A L+E+
Sbjct: 930 LEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRA 989
Query: 533 SLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEE---LHKQR 589
+ + L+ + + + + E A+LQ ++E E +L EE L ++R
Sbjct: 990 AHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQER 1049
Query: 590 DRALAVL---TEKDLELEQLRSVALASGLPGRRSPVG-----------GGGPGDPADTSS 635
D L + ++ L L++ AL+ L G R + D S+
Sbjct: 1050 DEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRST 1109
Query: 636 SDSLTQALQ-LAAANEPTFFLYAEQLARKEVEITSLRKQKHRL--EVEVHQLQDRLLEEG 692
++LT L+ L A E +A+++ R + + L KQ+ E E + Q RLLE+
Sbjct: 1110 VNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDA 1169
Query: 693 -ERHREEVAALQSHIEKNIRDQSREGANLE 721
+ R E+ Q + +S+EG ++
Sbjct: 1170 RDGLRRELLEAQRKLR-----ESQEGREVQ 1194
Score = 80.9 bits (198), Expect = 4e-15
Identities = 113/531 (21%), Positives = 213/531 (40%), Gaps = 63/531 (11%)
Query: 121 PARGPPPPKSEEASWSESGVSSSSGDGPFAGG--------------------EVDKRLHQ 160
PAR P S E S S + S G P + G E + L
Sbjct: 1461 PARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRS 1520
Query: 161 LKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQE 220
+ + L + + + ++ + MEA + + +Q L+ A ++EE R ++G L G+Q
Sbjct: 1521 AQRERDELRTQTSALNRQLAEMEAERDSATSRARQ-LQKAVAESEEARRSVDGRLSGVQA 1579
Query: 221 QIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAY 280
++A + + + +R A + R LQ E R ++ + + +
Sbjct: 1580 ELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRR 1639
Query: 281 AAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQ 340
E ++ E +T +L + L+ ELQ R + + + Q LQ+ L+ A +
Sbjct: 1640 LKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQV-ADSEV 1698
Query: 341 EMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLGTYE---KAKQKDQLAIQKL--- 394
+ L ++L E+ AL +++ ++E L + + L +QK
Sbjct: 1699 KAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTA 1758
Query: 395 ---KERILQ--LDLENKTLALAASSRSPLDS-----HGEESSLDVNVL--KDKMEKLKRL 442
++LQ LD + L+ A S L GE + L++ + + ++++L+ +
Sbjct: 1759 CEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREV 1818
Query: 443 LQVAARKSQVTLD-VEKLCDLEIMPSSEAADGEKATALYYQQE----------------L 485
L+ L+ V+KL D + ++A A ++ L
Sbjct: 1819 LRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVAL 1878
Query: 486 KQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQH 545
++ ++ ER K+R+ + + G L + L A+ +LAE + + L LE H
Sbjct: 1879 RRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSH 1938
Query: 546 ---QQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRAL 593
Q E D +Q+L Q++ R + Q +RTL+ E H+QR R L
Sbjct: 1939 SPAQLEVDAQQQQLELQQEVERLRSAQAQ---TERTLEARERAHRQRVRGL 1986
Score = 73.6 bits (179), Expect = 7e-13
Identities = 155/657 (23%), Positives = 269/657 (40%), Gaps = 112/657 (17%)
Query: 49 KEALEASIKVLSVSHEADVGLAGVQLPGLTFPDS-VDDRCSTHSEDSTGTATSLDTAASL 107
++ LE S++V + EA QLP L S + ++ + S +G L+ A
Sbjct: 801 RQGLEGSLRVAEQAQEA----LEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARRE 856
Query: 108 TSTKGEFGVEDDRPARGPPPPKSEEASWSESGVSSSSGDGPFAGGEVDKRLHQLKTQLAT 167
+ E +R AR E A + V++ G + + +L+ +
Sbjct: 857 AQRQVE---ALERAAREKEALAKEHAGLAVQLVAAER-----EGRTLSEEATRLRLEKEA 908
Query: 168 LTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQEQIAETKA 227
L SL V ++ +++EA ++ LE + L GEL GL++QI T+
Sbjct: 909 LEGSLFEVQRQLAQLEAR--------REQLEAEGQALLLAKETLTGELAGLRQQIIATQE 960
Query: 228 RLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEG 287
+ + AQ+ RE Q L+E+R ++ RL+ +EA A+ + E
Sbjct: 961 KASLDKELMAQKLVQAE---REAQASLREQRAAHEEDLQRLQREKEA----AWRELEAER 1013
Query: 288 FELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARL--KSHFQAQLQQEMRKT 345
+LQ+ QL RE EEL + L+A ++E ++ LQ+ ++E L QA +E KT
Sbjct: 1014 AQLQS-QLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKT 1072
Query: 346 ALAED-----------------QLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQ 388
AL+E Q R +EQ + + SE+ +L E+A
Sbjct: 1073 ALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHA 1132
Query: 389 LAIQKLKERILQLDLENKT-----------LALAASSRSPL------------------- 418
+++L+E+ L + + L L +R L
Sbjct: 1133 QEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGRE 1192
Query: 419 ---DSHGE------ESSLDVNVLKDKMEKLKRLLQVAA--RKSQVTLDVEKLCDLEIMPS 467
GE E + + L+ E+L+ ++ A R S + +K L ++
Sbjct: 1193 VQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEE 1252
Query: 468 SEAADGEKATAL---YYQQELKQLKEEFERYKMRAQV-VLKSKNTKDGNLGKELEAAQEQ 523
+ A G++A L + E +L+ E ++R Q+ +L S+NT+ LG+EL Q +
Sbjct: 1253 ARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTR---LGRELAELQGR 1309
Query: 524 L-----AELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRT 578
L AE + + +L L L+ + E +QEL Q+ +++L+ + +FR R
Sbjct: 1310 LALGERAEKESRRETLGLRQRLLKGEASLEV--MRQEL----QVAQRKLQEQEGEFRTRE 1363
Query: 579 LKLEEELHKQRDRALAVLTEK---DLELEQLRSVALASGLPGRRSPVGGGGPGDPAD 632
+L L + R L +L+LE R+ A GL R S G G A+
Sbjct: 1364 RRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGL--RLSAAEGRAQGLEAE 1418
Score = 68.9 bits (167), Expect = 2e-11
Identities = 108/458 (23%), Positives = 201/458 (43%), Gaps = 56/458 (12%)
Query: 154 VDKRLHQLKTQLATLTSSLATVTQEK-------SRMEASYLADKKKMKQDLEDASNKAEE 206
VD RL ++ +LA S+ +E+ + +E S A + +++ E S K +
Sbjct: 1570 VDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKIS-KMKA 1628
Query: 207 ERARLEGELKGLQEQIAETKARLITQQHDRAQEQ----------SDHALMLRELQKLLQE 256
+LEG+ + L+E + +++R + + R + SD + LQ +
Sbjct: 1629 NETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDS 1688
Query: 257 ERTQRQDLELR---LEETREALAGRAYAAEQMEG-FELQTKQLTREVEELKSELQAIRDE 312
+ Q D E++ L+ T E L G E+ EG + + LT + + + L + RD+
Sbjct: 1689 LQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDK 1748
Query: 313 KNQPDPRLQELQEEAARLKSHFQAQLQ--QEMRK--TALAEDQLRQQSQV---EEQRVAA 365
L + + L+ A Q E RK ++L E + +V E QRV A
Sbjct: 1749 NLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEA 1808
Query: 366 LENQISEVSELLGTYEKAKQKDQLAIQKLKE--RILQLDLENKTLALAASSRSPLDSHGE 423
E Q+ ++ E+L ++ + +QKL++ R+LQ L + ALA E
Sbjct: 1809 -EGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALA-------QLEAE 1860
Query: 424 ESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQ 483
+ ++ + L+ + ++ VA R++ ++ EKL E A G L
Sbjct: 1861 KREVERSALRLEKDR------VALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLT-GA 1913
Query: 484 ELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLS------ 537
EL+ + + + ++ AQVV+ ++ L E++A Q+QL EL+++ LR +
Sbjct: 1914 ELELAEAQRQIQQLEAQVVVLEQSHSPAQL--EVDAQQQQL-ELQQEVERLRSAQAQTER 1970
Query: 538 -CEELEHQHQQEADDWKQELARLQQLHRQELERCQLDF 574
E E H+Q +++++ L+ +QEL R F
Sbjct: 1971 TLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSSAPF 2008
Score = 65.9 bits (159), Expect = 1e-10
Identities = 135/538 (25%), Positives = 231/538 (42%), Gaps = 79/538 (14%)
Query: 245 LMLRELQKLLQEERTQRQDLELRLEETREALA-------GRAYAAEQMEGFELQTKQ--- 294
L L+E +LLQ+E ++ +DL + R+ LA R A ++E EL+T++
Sbjct: 77 LSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRG 136
Query: 295 LTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQ 354
L R+ EL+ +LQ + + QE Q+ A+L Q ++ Q ++ + E QL +
Sbjct: 137 LVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLE 196
Query: 355 QS-QVEEQRVAALENQISEVSELLGTYEKAKQKDQLA--IQKLKERILQLDLENKTLALA 411
+S ++E+QR+ E+ S L+ E+ ++ LA L+E++ Q N+ L+
Sbjct: 197 RSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSED 256
Query: 412 --------ASSRSPLDS-----HGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEK 458
R L+ EE S + + L QV + V+ +V+
Sbjct: 257 IRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVS-EVKM 315
Query: 459 LCDLEIMPSSEAADGEKA-TALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKEL 517
+ +++ GE A T+ Q+ L + RA+ L+ + L ++L
Sbjct: 316 FTERDLL----QLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQL 371
Query: 518 --------EAAQEQL------AELKEKYISLRLSCEELEHQH---QQEADDWKQELARLQ 560
+ AQ+Q+ A+L + L L+ + LE Q+ Q D ++L L+
Sbjct: 372 RDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALE 431
Query: 561 QLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVL--TEKDLELEQLRSVALAS----- 613
L Q E+ L+ D L++ L RD A AVL +E ++L A AS
Sbjct: 432 SLRLQ--EQAALETEDGE-GLQQTL---RDLAQAVLSDSESGVQLSGSERTADASNGSLR 485
Query: 614 GLPGRR--------SPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEV 665
GL G+R SP G P + SDS T AL +A ++ + + R E
Sbjct: 486 GLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQV-QDMRGRYEA 544
Query: 666 E---ITSLRKQKHRLEVEVHQLQDRLLEEGERHREEV-AALQSHIEKNIRDQSREGAN 719
+ +LRKQ E E L+++L +R R++ A+Q+H + Q AN
Sbjct: 545 SQDLLGTLRKQLSDSESERRALEEQL----QRLRDKTDGAMQAHEDAQREVQRLRSAN 598
Score = 55.5 bits (132), Expect = 2e-07
Identities = 48/225 (21%), Positives = 101/225 (44%), Gaps = 18/225 (8%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASY--LADKKKMKQDLEDAS----NKAEE 206
E K+ L Q+ TL +A + ++ E L + + +Q+ E A+ K ++
Sbjct: 1779 EARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQD 1838
Query: 207 ERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLEL 266
ER L+ L LQ +A+ +A + + + D + R L K+ +E+ +D
Sbjct: 1839 ERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHED--- 1895
Query: 267 RLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEE 326
T A + + G EL+ + R++++L++++ + ++ + P +L+ +
Sbjct: 1896 ----TVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQV-VVLEQSHSP----AQLEVD 1946
Query: 327 AARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQIS 371
A + + Q ++++ A E L + + QRV LE Q+S
Sbjct: 1947 AQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVS 1991
Score = 35.0 bits (79), Expect = 0.27
Identities = 173/780 (22%), Positives = 287/780 (36%), Gaps = 111/780 (14%)
Query: 24 QKKQLLQYQARLKDVVRAYKSLLKEKEALEASIKVLSVSHEADVGLAGVQLPGLTFPDSV 83
Q+ + LQ QAR D+ + S L+E E L +++L +A GL L
Sbjct: 1133 QEVRRLQEQAR--DLGKQRDSCLREAEELRTQLRLLE---DARDGLRRELL--------- 1178
Query: 84 DDRCSTHSEDSTGTATSLDTAASLTSTKGEFGVEDDRPARGPPPPKSEEASWSESGVSSS 143
+ E G A L + GE E + R +EE + S
Sbjct: 1179 -EAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRS-----NEELRSAVKKAESE 1232
Query: 144 SGDGPFAGGEVDKRL---HQLKTQLATLTSSLATVTQE--KSRMEASYLADKKKMKQDLE 198
A + +++L + +T + L T QE +SR+EA ++ Q+L
Sbjct: 1233 RISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEA------RRELQELR 1286
Query: 199 DASNKAEEERARLEGELKGLQEQIAETKARLITQQHDRAQEQS-DHALMLRELQKLLQEE 257
+ E RL EL AE + RL +RA+++S L LR Q+LL+ E
Sbjct: 1287 RQMKMLDSENTRLGREL-------AELQGRLAL--GERAEKESRRETLGLR--QRLLKGE 1335
Query: 258 RTQRQDLELRLEETREALAGRAYAAEQMEG-FELQTKQLTREVEELKSELQAIRDEKNQP 316
+ LE R+ L ++ EG F + ++L +EE + + D
Sbjct: 1336 AS--------LEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGL 1387
Query: 317 DPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSEL 376
+ +L+ + EAA L A E R L + R VE QR AA E Q+ +
Sbjct: 1388 ELKLEAARAEAAELGLRLSA---AEGRAQGLEAELAR----VEVQRRAA-EAQLGGLRSA 1439
Query: 377 LGT---YEKAKQKDQLAIQKLKERILQLDLE----NKTLALAASSRSPLDSHGEESS--- 426
L +A + R + N L S S S G +S
Sbjct: 1440 LRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPAS 1499
Query: 427 --LDVNVLKDKMEKLKRLLQVAAR-----KSQVTLDVEKLCDLE---------------- 463
LD ++ + + + L+ A R ++Q + +L ++E
Sbjct: 1500 PDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKA 1559
Query: 464 IMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNL---GKELEAA 520
+ S EA Q EL +E R + + L T + +L EL A+
Sbjct: 1560 VAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRAS 1619
Query: 521 QEQLAELKEKYISLRLSCEEL-EHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTL 579
QE+++++K L L E E+ K EL R + EL+R +L DR
Sbjct: 1620 QEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQR--RSLEGELQRSRLGLSDREA 1677
Query: 580 KLE------EELHKQRDRALAVLTEKDLELEQLR-SVALASGLPGRRSPVGGGGPGDPAD 632
+ + + L +Q + L +E+L ++A G G A
Sbjct: 1678 QAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQ 1737
Query: 633 TSSSDSLTQALQLAAANEPTFFLYAEQLARKEVE-----ITSLRKQKHRLEVEVHQLQDR 687
+S+S + T+ L T + Q+ ++ ++ ++ RKQ L +V L+
Sbjct: 1738 SSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGE 1797
Query: 688 LLEEGERHREEVAALQSHIEKNIRDQSREGANLEYLKNIIYRFLTLPDSLGRQQTLTAIL 747
+ + + E LQ E + Q E A L ++ + L + LG Q A L
Sbjct: 1798 VADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQL 1857
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 92.8 bits (229), Expect = 1e-18
Identities = 148/759 (19%), Positives = 315/759 (41%), Gaps = 99/759 (13%)
Query: 15 KDLLETIETQKKQLLQYQARLKDVVRAYKSLLKEKEALEASIK-VLSVSHEADVGLAGVQ 73
++ +E +ET +L++++A L ++ +EK +L+ IK + V E +A
Sbjct: 310 RETVEILETNHTELMEHEASLS------RNAQEEKLSLQQVIKDITQVMVEEGDNIA--- 360
Query: 74 LPGLTFPDSVDDRCSTHSEDSTGTATSLDTAASLTSTKGEFGVEDDRPARGPPPP----- 128
G +S++ S S+ A T T+ V+D R
Sbjct: 361 -QGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLL 419
Query: 129 KSEEASWSESGVS-------------SSSGDGPFAGGEVD---KRLHQLKTQLATLTSSL 172
+ + W E G + + +G GEVD K L+ L L
Sbjct: 420 QQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQL 479
Query: 173 ATVTQEKSRM-----EASYLADKKK-MKQDLEDASNKAEEERARLEGELKGLQEQIAETK 226
+ QE R+ E D + K++ ++ + A ER RL+ L GL+ + +E+
Sbjct: 480 EVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESL 539
Query: 227 ARLITQQHDRA----------QEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALA 276
+ LIT + QEQ++ L ++ + E + L+ + + R A
Sbjct: 540 SELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAV 599
Query: 277 GRAYAAEQME----GFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARL-- 330
+ E + G Q QL E + + S ++A +N L E ++ L
Sbjct: 600 KLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWE 659
Query: 331 -KSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQL 389
+H +AQLQ+ A + LR + +E+ ++ ++SE ++ + +
Sbjct: 660 KNTHLEAQLQKAEEAGAELQADLRDIQEEKEE----IQKKLSE----------SRHQQEA 705
Query: 390 AIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARK 449
A +L++ + + + LA A + L E+++L+V +++ ++R Q A +
Sbjct: 706 ATTQLEQLHQEAKRQEEVLARAVQEKEALVR--EKAALEV-----RLQAVERDRQDLAEQ 758
Query: 450 SQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTK 509
Q ++L + + + + + T + +++ + + E + + + +T+
Sbjct: 759 LQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTE 818
Query: 510 DGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELER 569
+E +AA QLA+ +++ + + E+ + H++E + +++ + + H+QEL +
Sbjct: 819 RSQAEQERDAAARQLAQAEQEG---KTALEQQKAAHEKEVNQLREKWEKERSWHQQELAK 875
Query: 570 CQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGD 629
++LE L +Q+ A+ +++ E Q S L + V
Sbjct: 876 ALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERV------- 928
Query: 630 PADTSSSDSLTQA-LQLAAANEPTFFLYAEQLARKEVEITSLRKQKHR--LEVEVHQLQD 686
S ++L Q +LA A++ + R+++++ L++Q+ L+ ++ + Q
Sbjct: 929 ----SLLETLLQTQKELADASQQL------ERLRQDMKVQKLKEQETTGILQTQLQEAQR 978
Query: 687 RLLEEGERHREEVAALQSHIEKNIRDQSREGANLEYLKN 725
L E +HR+++AALQ ++D+ +E LK+
Sbjct: 979 ELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKS 1017
Score = 92.8 bits (229), Expect = 1e-18
Identities = 130/538 (24%), Positives = 225/538 (41%), Gaps = 80/538 (14%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRME---ASYLADKKKM---KQDLEDASNKAEE 206
E+ K+L + + Q T+ L + QE R E A + +K+ + K LE E
Sbjct: 691 EIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVER 750
Query: 207 ERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQ-------EERT 259
+R L +L+GL ++ L Q + + + ++Q + Q E R
Sbjct: 751 DRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRC 810
Query: 260 QRQDLEL---RLEETREALAGRAYAAEQMEGFELQTKQLTREVE---------------- 300
+ +L+ + E+ R+A A + AEQ L+ ++ E E
Sbjct: 811 LKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQ 870
Query: 301 -ELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVE 359
EL L+++ EK + + RL+E Q E + Q Q+E +T + Q + E
Sbjct: 871 QELAKALESLEREKMELEMRLKEQQTEMEAI------QAQREEERTQAESALCQMQLETE 924
Query: 360 EQRVAALENQISEVSELLGTYEKAKQ-KDQLAIQKLKER----ILQLDLENKTLALAASS 414
++RV+ LE + EL ++ ++ + + +QKLKE+ ILQ L+ L ++
Sbjct: 925 KERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAA 984
Query: 415 RSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTL--DVEKLCDLEIMPSSEAAD 472
R D ++L+DKM+ K QV KSQ+ D ++L + E+
Sbjct: 985 RQHRDDLAALQEESSSLLQDKMDLQK---QVEDLKSQLVAQDDSQRLVEQEVQEK----- 1036
Query: 473 GEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYI 532
L QE ++++E ER K + L K + L + Q++L+ L+
Sbjct: 1037 ------LRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALR---- 1086
Query: 533 SLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEEL---HKQR 589
Q QEA ++EL+ +L RQE++ + DF + +L EEL H
Sbjct: 1087 -----------QDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITE 1135
Query: 590 DRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSS-DSLTQALQLA 646
+ A L ++ + QL+ + L S + PG+ A + SL ALQ A
Sbjct: 1136 QQLRASLWAQEAKAAQLQ-LRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQA 1192
Score = 82.0 bits (201), Expect = 2e-15
Identities = 113/470 (24%), Positives = 197/470 (41%), Gaps = 48/470 (10%)
Query: 177 QEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHD- 235
+E++R LA + + Q LE+ E E L LQ+Q AE Q+H+
Sbjct: 1865 KEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQ-----AQEHEV 1919
Query: 236 --RAQEQS---------DHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQ 284
RA + S + L L+ Q R Q + R E +EAL G+A+AA Q
Sbjct: 1920 ETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEAL-GKAHAALQ 1978
Query: 285 -MEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQE---LQE-EAARLKSHFQAQLQ 339
E L+ +L+R +E + LQA D +L+E +QE E +Q +Q
Sbjct: 1979 GKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQ 2038
Query: 340 QEMRKTALAEDQLRQQSQ------------VEEQRVAALEN--QISEVSELLGTYEKAKQ 385
Q + A +++LR Q + V+E + +N Q E E+ G ++ ++
Sbjct: 2039 QLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRE 2098
Query: 386 KDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQV 445
QL + + ++ IL+L + L A S S EE SL ++ L+ ++++ LQ
Sbjct: 2099 L-QLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQA 2157
Query: 446 AARKSQVTLDV--EKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVL 503
A R+++ EK DL + + A + + L+ + E+ +++ ++ L
Sbjct: 2158 ALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELEL 2217
Query: 504 KSKNTKDGNLGKELEAAQEQLAELKEKYISL-RLSCEELEHQHQ-QEADDWKQELARLQQ 561
+ + L + +L E+ + L +S E E E W+Q L LQQ
Sbjct: 2218 TRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQ 2277
Query: 562 ------LHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQ 605
+ R L+R + R ++E E K + A+ LE+ +
Sbjct: 2278 AVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISK 2327
Score = 79.0 bits (193), Expect = 2e-14
Identities = 125/579 (21%), Positives = 254/579 (43%), Gaps = 74/579 (12%)
Query: 157 RLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELK 216
++ LK QL TL + + +ME ++K+ ++LE + E +R L
Sbjct: 1544 QVQDLKKQLVTLECLALELEENHHKMEC-----QQKLIKELE---GQRETQRVALTHLTL 1595
Query: 217 GLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALA 276
L+E+ E +A+ +Q HD +S ++ RELQ+ QE ++QR+ +E L+ +E L
Sbjct: 1596 DLEERSQELQAQS-SQIHDL---ESHSTVLARELQERDQEVKSQREQIE-ELQRQKEHL- 1649
Query: 277 GRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQA 336
T+ L R +EL + + I+ ++Q + + L+E+ ++K
Sbjct: 1650 ---------------TQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIK----L 1690
Query: 337 QLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKE 396
L++ R+ ++++++ + A + + +L EK + Q I +L+E
Sbjct: 1691 SLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQE 1750
Query: 397 RILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDV 456
QL+ + + L S L S E+ ++ VL+ ++++ + ++ + Q LD
Sbjct: 1751 LKDQLEQQLQGLHRKVGETSLLLSQREQ---EIVVLQQQLQEAREQGELKEQSLQSQLDE 1807
Query: 457 EKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKE 516
+ + EA E+ A ++ +K+ + + +A + LK ++ + + ++
Sbjct: 1808 AQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQ 1867
Query: 517 LEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRD 576
+E+LA + +L EE+ + E+ + ++ L LQQ ++ + +++ R
Sbjct: 1868 ARRLEEELAVEGRRVQAL----EEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETR- 1922
Query: 577 RTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSS 636
L +A AVL E+D ELE LR+ + +S + A + +
Sbjct: 1923 -------ALQDSWLQAQAVLKERDQELEALRAESQSS------------RHQEEAARARA 1963
Query: 637 DSLTQALQLAAA----NEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQLQDRL-LEE 691
++L +AL A A E AE E +L+ + QL++ L ++E
Sbjct: 1964 EALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQE 2023
Query: 692 GE------RHREEVAALQSHI---EKNIRDQSREGANLE 721
GE R++E+V LQ + ++ +R Q LE
Sbjct: 2024 GEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLE 2062
Score = 77.8 bits (190), Expect = 4e-14
Identities = 146/612 (23%), Positives = 258/612 (42%), Gaps = 98/612 (16%)
Query: 161 LKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERAR-------LEG 213
L+ Q+ L L EKS++ QDL+ ++ +EE+++ LE
Sbjct: 1262 LRDQVQKLEERLTDTEAEKSQVHTEL--------QDLQRQLSQNQEEKSKWEGKQNSLES 1313
Query: 214 ELKGLQEQIAETKARLITQQHDRAQEQSDHALM----------LRELQKLLQEERTQRQD 263
EL L E +A ++RL + R + Q + L+ + LQ + E R Q
Sbjct: 1314 ELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASA 1373
Query: 264 LELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELK-SELQAIRDEKNQPDPRLQE 322
+ E+ R A + E++E E + Q +E ELK ++ +A+++ L E
Sbjct: 1374 AGILEEDLRTARSALKLKNEEVES-ERERAQALQEQGELKVAQGKALQENLALLTQTLAE 1432
Query: 323 LQEEAARLKSHFQ-AQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLGTYE 381
+EE L+ Q + Q+EM+K AL + L + Q V + QI E+ + E
Sbjct: 1433 REEEVETLRGQIQELEKQREMQKAAL--ELLSLDLKKRNQEVDLQQEQIQELEKCRSVLE 1490
Query: 382 KAKQKDQLAIQKL---KERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEK 438
Q QKL +E+I +L+ + +T NVL+ ++ +
Sbjct: 1491 HLPMAVQEREQKLTVQREQIRELEKDRET--------------------QRNVLEHQLLE 1530
Query: 439 LKRLLQ-VAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQ-LKEEFERYK 496
L++ Q + +++ QV ++L LE + A + E+ +++ E +Q L +E E +
Sbjct: 1531 LEKKDQMIESQRGQVQDLKKQLVTLECL----ALELEEN---HHKMECQQKLIKELEGQR 1583
Query: 497 MRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQEL 556
+V L +EL+A Q+ +L+ L +E + + + + + +EL
Sbjct: 1584 ETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQ-IEEL 1642
Query: 557 ARLQQLHRQELERCQLDFRDRTLKLEEE----LHKQRDRALAVLTEKDLE------LEQL 606
R ++ Q+LER RD+ L L++E L QR R +L E+DLE E+
Sbjct: 1643 QRQKEHLTQDLER-----RDQELMLQKERIQVLEDQRTRQTKIL-EEDLEQIKLSLRERG 1696
Query: 607 RSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQAL-----QLAAANEPTFFL------ 655
R + L R+ G G A S + + L ++ E L
Sbjct: 1697 RELTTQRQLMQERAEEGKG--PSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQ 1754
Query: 656 ---YAEQLARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRD 712
+ L RK E + L Q+ E E+ LQ +L E E+ + +LQS +++ R
Sbjct: 1755 LEQQLQGLHRKVGETSLLLSQR---EQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRA 1811
Query: 713 QSREGANLEYLK 724
++ LE L+
Sbjct: 1812 LAQRDQELEALQ 1823
Score = 76.6 bits (187), Expect = 8e-14
Identities = 140/591 (23%), Positives = 248/591 (41%), Gaps = 95/591 (16%)
Query: 160 QLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQ 219
Q +TQ LT + + ++A + DLE S E + E+K +
Sbjct: 1582 QRETQRVALTHLTLDLEERSQELQA-----QSSQIHDLESHSTVLARELQERDQEVKSQR 1636
Query: 220 EQIAETKARLITQQHDRAQEQSDHALML-RELQKLLQEERTQR-----QDLE-LRL---E 269
EQI E + + + + E+ D LML +E ++L+++RT++ +DLE ++L E
Sbjct: 1637 EQIEELQRQ--KEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRE 1694
Query: 270 ETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAAR 329
RE R E+ E + +K +E +K L+ E + ELQE +
Sbjct: 1695 RGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQ 1754
Query: 330 LKSHFQA----------QLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLGT 379
L+ Q L Q ++ + + QL++ + E + +L++Q+ E L
Sbjct: 1755 LEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQ 1814
Query: 380 YE---KAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKM 436
+ +A Q++Q Q +ER+ + + AL + + + HGE L+D
Sbjct: 1815 RDQELEALQQEQQQAQGQEERVKE-KADALQGALEQAHMTLKERHGE--------LQDHK 1865
Query: 437 EKLKRL---LQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEE-- 491
E+ +RL L V R+ Q +V L DL +E+ + EKA QQ +Q +E
Sbjct: 1866 EQARRLEEELAVEGRRVQALEEV--LGDLR----AESREQEKALLALQQQCAEQAQEHEV 1919
Query: 492 ----FERYKMRAQVVLKSKNTK------DGNLGKELEAAQEQLAELKEKYISLRLSCEEL 541
+ ++AQ VLK ++ + + + E A AE ++ + + +
Sbjct: 1920 ETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQG 1979
Query: 542 EHQHQQEADDWKQEL----ARLQ------QLHRQELERC----QLDFRDRTLKLEEELHK 587
+ QH E + + L A LQ Q H ++LE + + +D+ L+ +E++ +
Sbjct: 1980 KEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDV-Q 2038
Query: 588 QRDRALAVLTEK---DLELEQLRSVALASGLPGR--RSPVGGGGPGDPADTSSSDSLTQA 642
Q +ALA E+ E EQL +LA + + G + + +
Sbjct: 2039 QLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRE 2098
Query: 643 LQLAAANEPTFFLYAEQLARKEVEITSLR--KQKHRLEVEVHQLQDRLLEE 691
LQL LA+KE EI LR +Q++ LE H + +EE
Sbjct: 2099 LQLT-------------LAQKEQEILELRETQQRNNLEALPHSHKTSPMEE 2136
Score = 75.5 bits (184), Expect = 2e-13
Identities = 140/646 (21%), Positives = 258/646 (39%), Gaps = 127/646 (19%)
Query: 154 VDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERA---- 209
++ L +L +A+L S L E RMEA +++ ++ E+ + + E +A
Sbjct: 1311 LESELMELHETMASLQSRLRRA--ELQRMEAQ--GERELLQAAKENLTAQVEHLQAAVVE 1366
Query: 210 -RLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRL 268
R + G+ E+ T + +++ + + + A L+E +L + Q + L+ L
Sbjct: 1367 ARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGEL---KVAQGKALQENL 1423
Query: 269 EETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQ---- 324
+ LA R E + G ++Q + RE+++ EL ++ +K + LQ+ Q
Sbjct: 1424 ALLTQTLAEREEEVETLRG-QIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQEL 1482
Query: 325 EEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVS---------- 374
E+ + H +Q+ +K + +Q+R+ + E + LE+Q+ E+
Sbjct: 1483 EKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQR 1542
Query: 375 ------------------ELLGTYEK--AKQK--DQLAIQKLKERI----LQLDLENKTL 408
EL + K +QK +L Q+ +R+ L LDLE ++
Sbjct: 1543 GQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQ 1602
Query: 409 ALAASSRS--PLDSHG-------EESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKL 459
L A S L+SH +E +V ++++E+L+R +K +T D+E+
Sbjct: 1603 ELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQR------QKEHLTQDLERR 1656
Query: 460 CDLEIMPSSE----AADGEKATALYYQQELKQLKEEFER--YKMRAQVVLKSKNTKDG-- 511
D E+M E D +++L+Q+K ++ Q L + ++G
Sbjct: 1657 -DQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKG 1715
Query: 512 -----------------NLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEA---DD 551
+ KE+E QE + EL+E L + L + + +
Sbjct: 1716 PSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQ 1775
Query: 552 WKQELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVAL 611
+QE+ LQQ ++ E+ +L E+ L Q D A L ++D ELE L+
Sbjct: 1776 REQEIVVLQQQLQEAREQGELK--------EQSLQSQLDEAQRALAQRDQELEALQQEQQ 1827
Query: 612 ASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEIT--- 668
+ G+ V + AD + +L QA + EQ R E E+
Sbjct: 1828 QA--QGQEERV-----KEKAD-ALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEG 1879
Query: 669 -----------SLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQ 703
LR + E + LQ + E+ + H E ALQ
Sbjct: 1880 RRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQ 1925
Score = 67.4 bits (163), Expect = 5e-11
Identities = 138/637 (21%), Positives = 268/637 (42%), Gaps = 78/637 (12%)
Query: 131 EEASWSESGVSSSSGDGPFAGGEVDKRLHQLKTQLATLT-----------SSLATVTQEK 179
+E SW + ++ + E++ RL + +T++ + S+L + E
Sbjct: 864 KERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLET 923
Query: 180 SRMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHDRAQE 239
+ S L + +++L DAS + ER R + +++ L+EQ ET L TQ + +E
Sbjct: 924 EKERVSLLETLLQTQKELADASQQL--ERLRQDMKVQKLKEQ--ETTGILQTQLQEAQRE 979
Query: 240 QSDHALMLRELQKLLQEERT----QRQDLELRLEETREALAGRAYAAEQMEGFELQTK-- 293
+ A R+ LQEE + + DL+ ++E+ + L + + +E E+Q K
Sbjct: 980 LKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQ-EVQEKLR 1038
Query: 294 ------QLTREVEELKSELQAIRDEKNQPDPRLQEL----QEEAARLKSHFQAQLQQEMR 343
++ +E+E K+ L EK Q LQE Q+E + L+ Q + Q E +
Sbjct: 1039 ETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQ-EAQGEQK 1097
Query: 344 KTALAEDQLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDL 403
+ + + LRQ+ + +E A E Q+ E E E+ + + L Q+ K LQL L
Sbjct: 1098 ELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQ-QLRASLWAQEAKAAQLQLRL 1156
Query: 404 ENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEK-LKRLLQVAARKSQVTLDVEKLCDL 462
+ L A + + ++ + L +++ L + + S + L
Sbjct: 1157 RSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGL 1216
Query: 463 EIMPSSEAA-----DGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKEL 517
E P A G TAL + L +K+ Q + K++ T+D L ++
Sbjct: 1217 E--PDQNGARSLFKRGPLLTALSAEAVASAL------HKLH-QDLWKTQQTRD-VLRDQV 1266
Query: 518 EAAQEQLAELKEKYISLRLSCEELEH---QHQQEADDWKQELARLQQLHRQELERCQLDF 574
+ +E+L + + + + ++L+ Q+Q+E W+ + L+ EL
Sbjct: 1267 QKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLES-ELMELHETMASL 1325
Query: 575 RDRTLKLE-EELHKQRDRALAVLTEKDLELE---------QLRSVALASG-----LPGRR 619
+ R + E + + Q +R L +++L + + R+ A A+G L R
Sbjct: 1326 QSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTAR 1385
Query: 620 SPVGGGGPGDPADTSSSDSLTQALQLAAAN----EPTFFLYAEQLARKEVEITSLRKQKH 675
S + ++ + +L + +L A + L + LA +E E+ +LR Q
Sbjct: 1386 SALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQ 1445
Query: 676 RLEVEVHQLQDRLLE----EGERHREEVAALQSHIEK 708
LE + ++Q LE + ++ +EV Q I++
Sbjct: 1446 ELEKQ-REMQKAALELLSLDLKKRNQEVDLQQEQIQE 1481
Score = 56.2 bits (134), Expect = 1e-07
Identities = 104/491 (21%), Positives = 201/491 (40%), Gaps = 44/491 (8%)
Query: 211 LEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEE 270
LE ++ LQ+Q+AE +A + + + Q A ++R+LQ + + R+ Q+LE RLE
Sbjct: 20 LEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEA 79
Query: 271 TREALAGRAYAAEQMEGFEL-----QTKQLTREVEELKSELQAIRDEKNQPDPRLQELQE 325
T + R E+ EL + +Q + E+ ++L+ ++ + + L+E E
Sbjct: 80 TGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVE 139
Query: 326 EAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQ 385
+ S + +L ++ + + ++ + + E R+ +L ++ + A
Sbjct: 140 KLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATD 199
Query: 386 KDQLAIQ----KLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKR 441
+D + ++ +L +L L L + A SR P + G + L + K +
Sbjct: 200 RDLMELKAEHVRLSGSLLTCCLR---LTVGAQSREP-NGSGRMDGREPAQLLLLLAKTQE 255
Query: 442 LLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQV 501
L + A +SQ + ++ DLE +E D + Q KQ E++E+ +
Sbjct: 256 LEKEAHERSQELIQLKSQGDLE---KAELQDRVTELSALLTQSQKQ-NEDYEKMIKALRE 311
Query: 502 VLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQ 561
++ T L E EA+ + A+ E+ +SL+ +++ +E D+ Q
Sbjct: 312 TVEILETNHTEL-MEHEASLSRNAQ--EEKLSLQQVIKDITQVMVEEGDNIAQGSGHENS 368
Query: 562 LHRQELERCQLDFRDRTLKLEEELHKQRDRAL----AVLTEKDLELEQLRSVALASGLPG 617
L Q D++D D+AL +VLT + ++ LR L G
Sbjct: 369 LELDSSIFSQFDYQD------------ADKALTLVRSVLTRRRQAVQDLR-----QQLAG 411
Query: 618 RRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRL 677
+ V +L Q LQ T A Q + E+ SL K++ L
Sbjct: 412 CQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTL---AGQTVDLQGEVDSLSKERELL 468
Query: 678 EVEVHQLQDRL 688
+ +L+ +L
Sbjct: 469 QKAREELRQQL 479
Score = 46.6 bits (109), Expect = 9e-05
Identities = 79/312 (25%), Positives = 142/312 (45%), Gaps = 42/312 (13%)
Query: 176 TQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHD 235
TQ+++ +EA + K +E+ S K + RL+ EL+ LQ + +T+AR I + +
Sbjct: 2116 TQQRNNLEALPHSHKTS---PMEEQSLKLDSLEPRLQRELERLQAALRQTEAREI-EWRE 2171
Query: 236 RAQEQSDHALMLRE--------------LQKLLQEERTQRQDLELRLEETREALAGR--- 278
+AQ D AL L + LQ + E +++Q L+ LE TR AL
Sbjct: 2172 KAQ---DLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLH 2228
Query: 279 ---AYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQ 335
A + ++ Q QL EV +++E EK RL+ LQ+ ARL+ +
Sbjct: 2229 SPGATSTAELGSRGEQGVQLG-EVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEID-R 2286
Query: 336 AQLQQ---EMRKTALAEDQLRQQSQVEEQRVA-ALENQISEVSELLGTYEKA---KQKDQ 388
++LQ+ ++R T ++ R++ + E R A A +IS+ + T + K D
Sbjct: 2287 SRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDA 2346
Query: 389 LAIQKLKERIL----QLDLENKTLA--LAASSRSPLDSHGEESSLDVNVLKDKMEKLKRL 442
+ +L++ ++ QL LE K + S+++ + G SL ++L +
Sbjct: 2347 KCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATV 2406
Query: 443 LQVAARKSQVTL 454
L+ R+ +L
Sbjct: 2407 LEAETRRLDESL 2418
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 91.3 bits (225), Expect = 3e-18
Identities = 137/644 (21%), Positives = 273/644 (42%), Gaps = 83/644 (12%)
Query: 157 RLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNK---AEEERARLEG 213
R +L L +A+ QE + Y D +++++ ++DA+ E ER ++
Sbjct: 493 RERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSA 552
Query: 214 ELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETRE 273
++GLQ ++ ET Q + + D +EL +L E+ ++L ++E +
Sbjct: 553 LVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQR 612
Query: 274 ALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPD---------------- 317
L +A E+ K+L R EELK ELQA R +
Sbjct: 613 ELEQARASAGDTRQVEVLKKELLRTQEELK-ELQAERQSQEVAGRHRDRELEKQLAVLRV 671
Query: 318 --PRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSE 375
R +EL+E+ +L+ Q QL+Q+ + + A+ ++ V QR AA+E + E E
Sbjct: 672 EADRGRELEEQNLQLQKTLQ-QLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQE 730
Query: 376 --------LLGTYEKAKQKDQL-----AIQ-KLKERILQLDLENKTL------------A 409
+LG ++ K+ L A++ +L++++ +L+ E + L +
Sbjct: 731 ENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGS 790
Query: 410 LAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTL-------DVEKLCDL 462
LAA+ R+ L++ EE+ + L + + L R L+ ++ +V + ++L D
Sbjct: 791 LAAAKRA-LEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDR 849
Query: 463 EIMPSSEAAD--GEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAA 520
+ ++ + GE + +Q L+QL+ + E YK +A+ + + + E E
Sbjct: 850 TVDRLNKELEKIGEDS-----KQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKT 904
Query: 521 QEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQ-ELERCQLDFRDRTL 579
L+ L+++ LR + + + + D + RLQ L ++ E ++ D R R L
Sbjct: 905 SGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQL 964
Query: 580 K--------LEEELHKQRDRALAVLTEK---------DLELEQLRSVALASGLPGRRSPV 622
K LE EL ++++ + +LT++ L E ++ + L + +
Sbjct: 965 KGLEEKVSRLETELDEEKN-TVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISL 1023
Query: 623 GGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVH 682
+SS+ + + E L E+L +E E T L+ +LE +V
Sbjct: 1024 ERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVK 1083
Query: 683 QLQDRLLEEGERHREEVAALQSHIEKNIRDQSREGANLEYLKNI 726
+L ++ +E + ++ L ++ R +E L +
Sbjct: 1084 ELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGL 1127
Score = 85.5 bits (210), Expect = 2e-16
Identities = 136/626 (21%), Positives = 252/626 (40%), Gaps = 94/626 (15%)
Query: 140 VSSSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLED 199
VSS S GE+ +++ +L+ +L +++ ++E S + ++++++ E+
Sbjct: 350 VSSGSTKAVAGQGELTRKVEELQRKLDE-------EVKKRQKLEPSQVGLERQLEEKTEE 402
Query: 200 ASNKAEEERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERT 259
S + +E R +GE + +++ K RL+ Q D + L+ K +Q
Sbjct: 403 CS-RLQELLERRKGEAQQSNKELQNMK-RLLDQGEDLRHGLETQVMELQNKLKHVQGPEP 460
Query: 260 QRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPR 319
++ L L ETRE L E +EG + +QL EL + A+++E D
Sbjct: 461 AKEVLLKDLLETRELLE------EVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQE 514
Query: 320 LQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLGT 379
++ ++++ R + +Q + A+ E + ++ S + V L+ ++ E SE G
Sbjct: 515 VEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSAL----VRGLQRELEETSEETGH 570
Query: 380 YEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKL 439
++ QK++ ++ K+ +LQL +E + + EE L +K+E L
Sbjct: 571 WQSMFQKNKEDLRATKQELLQLRMEKEEM--------------EEE------LGEKIEVL 610
Query: 440 KRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFE------ 493
+R L+ A + T VE L K L Q+ELK+L+ E +
Sbjct: 611 QRELEQARASAGDTRQVEVL---------------KKELLRTQEELKELQAERQSQEVAG 655
Query: 494 RYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQH---QQEAD 550
R++ R + + + G+ELE EQ +L++ LR CEE + EA
Sbjct: 656 RHRDRELEKQLAVLRVEADRGRELE---EQNLQLQKTLQQLRQDCEEASKAKMVAEAEAT 712
Query: 551 DWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRD-----RALAVLTEKDLELEQ 605
Q A ++ R+ E +FR R L LE++L + R A+ L+ +
Sbjct: 713 VLGQRRAAVETTLRETQEEND-EFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLE 771
Query: 606 LRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEV 665
L L + G A + + + L + T E+ ++
Sbjct: 772 AEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQRE 831
Query: 666 EI----TSLRKQKHRLEVEV------------------HQLQDRLLEEGERHREEVAALQ 703
+ L +QK L+ V QLQ +L + E+ R EVA Q
Sbjct: 832 VLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQ 891
Query: 704 SHIEKNIRDQSREGANLEYLKNIIYR 729
+ + + L L++ I R
Sbjct: 892 RQAKDWASEAEKTSGGLSRLQDEIQR 917
Score = 61.2 bits (147), Expect = 3e-09
Identities = 78/351 (22%), Positives = 153/351 (43%), Gaps = 57/351 (16%)
Query: 151 GGEVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERAR 210
G + + L QL+ QL +EK+R E +AD ++ +D + K +R
Sbjct: 862 GEDSKQALQQLQAQLEDY--------KEKARRE---VADAQRQAKDWASEAEKTSGGLSR 910
Query: 211 LEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEE 270
L+ E++ L++ + ++A +R + D L+ + LQ L QE +++ + R
Sbjct: 911 LQDEIQRLRQALQASQA-------ERDTARLDKELLAQRLQGLEQEAENKKRSQDDR--- 960
Query: 271 TREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARL 330
A Q++G E + +L E++E K+ ++ + D N+ ++ +L+ E +
Sbjct: 961 -----------ARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQE 1009
Query: 331 KSHFQ--------AQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLGTYEK 382
+S Q + Q + KT LA + Q+ ++ LE+Q + E L E+
Sbjct: 1010 RSARQDLECDKISLERQNKDLKTRLASSEGFQKPSAS---LSQLESQNQLLQERLQAEER 1066
Query: 383 AKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLK-------DK 435
K Q +KL+ ++ +L ++ R ++ ++ SL V LK ++
Sbjct: 1067 EKTVLQSTNRKLERKVKELSIQ------IEDERQHVNDQKDQLSLRVKALKRQVDEAEEE 1120
Query: 436 MEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELK 486
+E+L L + A R+ + +V + I S E KA+ + LK
Sbjct: 1121 IERLDGLRKKAQREVEEQHEVNEQLQARI-KSLEKDSWRKASRSAAESALK 1170
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 90.5 bits (223), Expect = 5e-18
Identities = 132/622 (21%), Positives = 254/622 (40%), Gaps = 71/622 (11%)
Query: 162 KTQLATLTSSLATVTQEKSRMEASYLADKKKMKQ----------DLEDASNKAEEERARL 211
K L L +E+ M + +A K+ ++ DLE K E+E+
Sbjct: 916 KILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHAT 975
Query: 212 EGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQ----------KLLQEERTQR 261
E ++K L E++ + + ++ Q H L +LQ K+ + Q
Sbjct: 976 ENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQT 1035
Query: 262 QDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQ 321
DLE LE+ ++ A A ++EG K + +L+++ Q I ++ + + L
Sbjct: 1036 DDLEGSLEQEKKLRADLERAKRKLEG---DLKMSQESIMDLENDKQQIEEKLKKKEFELS 1092
Query: 322 ELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQIS----EVSELL 377
+LQ + + H Q Q+++++ ++L ++ + E A +E Q S E+ E+
Sbjct: 1093 QLQAKIDDEQVH-SLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEIS 1151
Query: 378 GTYEKAKQKDQLAIQKLKER-----ILQLDLENKTL---ALAASSR-SPLDSHGE--ESS 426
E+A I+ K+R ++ DLE TL A AA+ R DS E E
Sbjct: 1152 ERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQI 1211
Query: 427 LDVNVLKDKMEKLKRLLQV--------AARKSQVTLDVEKLC-DLEIMPSSEAADGEKAT 477
++ +K K+EK K L++ S+ ++E+ C +E S A E+ T
Sbjct: 1212 DNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQT 1271
Query: 478 ALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEK------- 530
L + +++ + + + ++ +V + K + L K +A +QL ELK +
Sbjct: 1272 QLIHDLNMQKARLQTQNGELSHRV--EEKESLISQLTKSKQALTQQLEELKRQMEEETKA 1329
Query: 531 -------YISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEE 583
S R C+ L Q+++E + K EL R E+ + + + ++ E
Sbjct: 1330 KNAMAHALQSSRHDCDLLREQYEEE-QEAKAELQRALSKANSEVAQWRTKYETDAIQRTE 1388
Query: 584 ELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQAL 643
EL + + + L E + E S + L + + G D S + L
Sbjct: 1389 ELEEAKKKLAQRLQEAEENTETANS--KCASLEKTKQRLQGEVEDLMRDLERSHTACATL 1446
Query: 644 QLAAAN-EPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQLQ---DRLLEEGERHREEV 699
N + + ++L + E+ + +K+ L E+ +++ + ++++ E R E
Sbjct: 1447 DKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRREN 1506
Query: 700 AALQSHIEKNIRDQSREGANLE 721
LQ I + G NL+
Sbjct: 1507 KNLQEEISDLTEQIAETGKNLQ 1528
Score = 85.1 bits (209), Expect = 2e-16
Identities = 170/775 (21%), Positives = 323/775 (41%), Gaps = 109/775 (14%)
Query: 14 KKDLLETIET--QKKQLLQYQAR-----LKDVVRAYKSLLKEKEALEASIKVLSVSHEAD 66
+K+L E + + Q+K LQ Q + L D + L+K K LEA +K L+ E +
Sbjct: 874 RKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEE 933
Query: 67 VGLAGVQLPGLTFPDSVDDRCSTHSEDSTGTATSLDTAASLTSTKGEFGVEDDRPARGPP 126
+ + +++D+CS+ D D +LT + E +++
Sbjct: 934 EEMNSEL---VAKKRNLEDKCSSLKRDID------DLELTLTKVEKEKHATENKVKN--- 981
Query: 127 PPKSEEASWSESGVSSSSGDGPFAGGEVDKRLHQLKTQ---LATLTSSLATVTQEKSRME 183
SEE + E +S + + + L L+ + + L A + Q+ +E
Sbjct: 982 --LSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLE 1039
Query: 184 ASYLADKKKMKQDLEDASNK--------------AEEERARLEGELKGLQEQIAETKARL 229
S L +KK++ DLE A K E ++ ++E +LK + ++++ +A++
Sbjct: 1040 GS-LEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKI 1098
Query: 230 ITQQHDRAQEQ---SDHALMLRELQKLLQEERT-------QRQDLELRLEETREALAGRA 279
+Q Q Q + + EL++ ++ E T QR DL LEE E L +
Sbjct: 1099 DDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEAS 1158
Query: 280 YAA----EQMEGFELQTKQLTREVEE--LKSELQAIRDEKNQPD------PRLQELQEEA 327
A E + E + +++ R++EE L+ E A K Q D ++ LQ
Sbjct: 1159 GATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVK 1218
Query: 328 ARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKD 387
+L+ +++L+ E+ A + L + E+ +E+Q SE+ K +Q+
Sbjct: 1219 QKLEKE-KSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIK------AKDEQQT 1271
Query: 388 QLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEES----SLDVNVLKDKME---KLK 440
QL I L + +L +N L+ + L S +S + + LK +ME K K
Sbjct: 1272 QL-IHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAK 1330
Query: 441 RLLQVAARKSQVTLDV-------EKLCDLEIMPSSEAADGEKA--------TALYYQQEL 485
+ A + S+ D+ E+ E+ + A+ E A A+ +EL
Sbjct: 1331 NAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEEL 1390
Query: 486 KQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQH 545
++ K++ + A+ ++ N+K +L K + Q ++ +L +C L+ +
Sbjct: 1391 EEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQ 1450
Query: 546 Q---QEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTE-KDL 601
+ + +WKQ+L Q ELE Q + R L EL K R+ V+ + + L
Sbjct: 1451 RNFDKVLAEWKQKLDESQ----AELEAAQKESR----SLSTELFKMRNAYEEVVDQLETL 1502
Query: 602 ELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAE-QL 660
E S L + + G + LQ+A + E ++
Sbjct: 1503 RRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKI 1562
Query: 661 ARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVA-ALQSHIEKNIRDQS 714
R ++E++ ++ + R +E +D +E+ +R+ + A ALQS ++ IR ++
Sbjct: 1563 LRVQLELSQVKSELDRKVIE----KDEEIEQLKRNSQRAAEALQSVLDAEIRSRN 1613
Score = 73.9 bits (180), Expect = 5e-13
Identities = 120/554 (21%), Positives = 231/554 (41%), Gaps = 86/554 (15%)
Query: 193 MKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHD---RAQEQSDHALMLRE 249
MK+D E + +EE AR E K L+E++ L+ +++D + Q ++++ + E
Sbjct: 856 MKEDFE----RTKEELARSEARRKELEEKMVS----LLQEKNDLQLQVQSETENLMDAEE 907
Query: 250 ------LQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELK 303
K+L E + ++L RLEE E + + E + L R++++L+
Sbjct: 908 RCEGLIKSKILLEAKV--KELTERLEEEEEM---NSELVAKKRNLEDKCSSLKRDIDDLE 962
Query: 304 SELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRV 363
L + EK+ + +++ L EE L+ + ++L +E + A Q QVEE +V
Sbjct: 963 LTLTKVEKEKHATENKVKNLSEEMTALEENI-SKLTKEKKSLQEAHQQTLDDLQVEEDKV 1021
Query: 364 AALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGE 423
N + +++ L +Q D L +E+ L+ DLE L + +
Sbjct: 1022 ----NGLIKINAKL-----EQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKM-----SQ 1067
Query: 424 ESSLDVNVLKDKM-EKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQ 482
ES +D+ K ++ EKLK+ + E+ D E+ +L +Q
Sbjct: 1068 ESIMDLENDKQQIEEKLKKK------------------EFELSQLQAKIDDEQVHSLQFQ 1109
Query: 483 QELKQLKEEFERY--KMRAQVVLKSKNTKD-GNLGKELEAAQEQLAEL------------ 527
+++K+L+ E ++ A+ L++K K +L +ELE E+L E
Sbjct: 1110 KKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNK 1169
Query: 528 --KEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEEL 585
+ ++ +R EE QH+ A +++ A ++++ Q +++++L
Sbjct: 1170 KREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQ--------RVKQKL 1221
Query: 586 HKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQL 645
K++ + + +E L S + V A L L +
Sbjct: 1222 EKEKSELKMEIDDMASNIEALSK--SKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNM 1279
Query: 646 AAANEPT-FFLYAEQLARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQS 704
A T + ++ KE I+ L K K L ++ +L+ ++ EE + ALQS
Sbjct: 1280 QKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQS 1339
Query: 705 --HIEKNIRDQSRE 716
H +R+Q E
Sbjct: 1340 SRHDCDLLREQYEE 1353
Score = 64.7 bits (156), Expect = 3e-10
Identities = 127/632 (20%), Positives = 242/632 (38%), Gaps = 95/632 (15%)
Query: 17 LLETIETQKKQLLQYQARLKDVVRAYKSLL----KEKEALEASIKVLSVSHEADVGLAGV 72
L+ + QK +L L V +SL+ K K+AL ++ L E +
Sbjct: 1273 LIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNA 1332
Query: 73 QLPGLTFPDSVDDRCSTHSEDSTGTATSLDTAASLTSTKGEFGVEDDRPARGPPPPKSEE 132
L D E+ L A S + SE
Sbjct: 1333 MAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKAN--------------------SEV 1372
Query: 133 ASWS---ESGVSSSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLAD 189
A W E+ + + A ++ +RL + + T S A++ + K R++ +
Sbjct: 1373 AQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQG----E 1428
Query: 190 KKKMKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRE 249
+ + +DLE ++ A L+ + + + +AE K +L Q + Q + + E
Sbjct: 1429 VEDLMRDLE----RSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTE 1484
Query: 250 LQKL----------LQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREV 299
L K+ L+ R + ++L+ + + E +A ++ E +TK+L V
Sbjct: 1485 LFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAE----KTKKL---V 1537
Query: 300 EELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVE 359
E+ KS+LQ +E + L+ + + R++ +Q++ E+ + + +D+ +Q +
Sbjct: 1538 EQEKSDLQVALEE---VEGSLEHEESKILRVQLEL-SQVKSELDRKVIEKDEEIEQLKRN 1593
Query: 360 EQRVAALENQISEVSELLGTYEKAKQKDQLAIQK-----LKERILQLDLENKTLALAASS 414
QR A + + E + D L ++K L E +QL N+ +A
Sbjct: 1594 SQRAAEALQSVLDA-------EIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKH 1646
Query: 415 RSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGE 474
+ ++S L ++ E LK L + R++ + L+ E+ A +
Sbjct: 1647 LRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLE-------ELEEMKVALEQT 1699
Query: 475 KATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISL 534
+ T +QEL + + +L S+NT N K+LEA Q E I
Sbjct: 1700 ERTRRLSEQELLDASDRVQ--------LLHSQNTSLINTKKKLEADIAQCQAEVENSIQE 1751
Query: 535 RLSCEELEHQHQQEADDWKQELARLQ------QLHRQELERCQLDFRDRTLKLEEELHKQ 588
+ EE + +A +EL + Q + ++ LE+ D + R + E+ K
Sbjct: 1752 SRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKG 1811
Query: 589 RDRALAVL------TEKDLELEQLRSVALASG 614
+ + L E +L++EQ R G
Sbjct: 1812 GKKQIQKLENRVRELENELDVEQKRGAEALKG 1843
Score = 56.2 bits (134), Expect = 1e-07
Identities = 82/408 (20%), Positives = 164/408 (40%), Gaps = 63/408 (15%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLE 212
E D+ + QLK +L +V + R L KKKM+ DL + +E
Sbjct: 1582 EKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNE-----------ME 1630
Query: 213 GELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETR 272
+L Q+AET QK L+ + Q +D +L L+
Sbjct: 1631 IQLGHSNRQMAET-------------------------QKHLRTVQGQLKDSQLHLD--- 1662
Query: 273 EALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKS 332
+AL EQ+ E + L E+EE+K L+ + + L + + L S
Sbjct: 1663 DALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHS 1722
Query: 333 HFQAQLQQEMRKTA-LAEDQLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQLA- 390
+ + + + A +A+ Q ++ ++E R A + + + + E K++D A
Sbjct: 1723 QNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAH 1782
Query: 391 IQKLKERILQL--DLENK-----TLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLL 443
++++K+ + Q DL+++ LAL + + L++++ +L+ L
Sbjct: 1783 LERMKKNLEQTVKDLQHRLDEAEQLALKGGKK------------QIQKLENRVRELENEL 1830
Query: 444 QVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVL 503
V ++ L + ++ + A+ + L Q + +L+ + + YK +A+
Sbjct: 1831 DVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAE 1890
Query: 504 KSKNTKDGNLGK---ELEAAQEQLAELKEKYISLRLSCEELEHQHQQE 548
+ NT+ + ELE A E+ + + LR ++ Q +E
Sbjct: 1891 EQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQKMEE 1938
Score = 53.1 bits (126), Expect = 9e-07
Identities = 77/440 (17%), Positives = 189/440 (42%), Gaps = 63/440 (14%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLE 212
EV +L L+ + L ++ +T++ +A+ K Q+ E E+E++ L+
Sbjct: 1494 EVVDQLETLRRENKNLQEEISDLTEQ--------IAETGKNLQEAEKTKKLVEQEKSDLQ 1545
Query: 213 GELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQD--------L 264
L+ ++ + +++++ Q + +Q +S+ + E + +++ + Q L
Sbjct: 1546 VALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVL 1605
Query: 265 ELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRL---- 320
+ + +AL + + E+Q R++ E + L+ ++ + L
Sbjct: 1606 DAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDAL 1665
Query: 321 ---QELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQ-------RVAALENQ- 369
++L+E+ A ++ L +E+ + +A +Q + ++ EQ RV L +Q
Sbjct: 1666 RSNEDLKEQLAIVERR-NGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQN 1724
Query: 370 ----------ISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLD 419
+++++ E + Q+ + A +K K+ I + + L + + L+
Sbjct: 1725 TSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1784
Query: 420 SHGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTL-----DVEKLCDLEIMPSSEAADGE 474
+ V L+ ++++ ++L +K L ++E D+E +EA G
Sbjct: 1785 RMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKG- 1843
Query: 475 KATALYYQQELKQL---KEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKY 531
A Y++++K++ EE + +R Q ++ K + ++ E A+EQ
Sbjct: 1844 ---AHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQ-------- 1892
Query: 532 ISLRLS-CEELEHQHQQEAD 550
+ +LS C ++H+ ++ A+
Sbjct: 1893 ANTQLSRCRRVQHELEEAAE 1912
Score = 34.3 bits (77), Expect = 0.45
Identities = 31/122 (25%), Positives = 56/122 (45%), Gaps = 27/122 (22%)
Query: 463 EIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQE 522
+I P ++A+ EK E+ +KE+FER K +EL ++
Sbjct: 839 KIKPLLKSAEAEK--------EMATMKEDFERTK------------------EELARSEA 872
Query: 523 QLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLE 582
+ EL+EK +SL +L+ Q Q E ++ R + L + ++ + ++ T +LE
Sbjct: 873 RRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKI-LLEAKVKELTERLE 931
Query: 583 EE 584
EE
Sbjct: 932 EE 933
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 90.5 bits (223), Expect = 5e-18
Identities = 149/643 (23%), Positives = 275/643 (42%), Gaps = 115/643 (17%)
Query: 160 QLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQ 219
+L+ Q+A L + +E ++A L++ K ++ A A E+ L Q
Sbjct: 2053 ELENQIAQLNKEKELLVKESESLQAR-LSESDYEKLNVSKALEAALVEKGEFALRLSSTQ 2111
Query: 220 EQIAET-----KARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREA 274
E++ + K R+ + ++ Q L RE + +++ + + EL++ E +
Sbjct: 2112 EEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQE 2171
Query: 275 LA--GRAYAAEQMEGFELQTKQLTREVE-------ELKSELQAIRDEKNQPDPRLQELQE 325
L + ++E + Q +++ R ++ L+SE + + + + +L EL +
Sbjct: 2172 LVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDK 2231
Query: 326 EAARLKSHFQAQLQQEMR---KTALAEDQLRQQSQVEEQRVAAL---------------- 366
+ KS + + Q E++ ++ A + L+ Q + + VAAL
Sbjct: 2232 LLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDP 2291
Query: 367 ----ENQISEVSELLGTYEKAKQKDQLAI-QKLKERILQLDL-----EN--KTLALAASS 414
E+Q+ E L +A +K QL + Q+LKE DL EN + L +A ++
Sbjct: 2292 PIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTN 2351
Query: 415 RSPLDSHGEESSLDVNVLKDKMEKLKRLLQ--------VAARKSQVTLDV----EKLCDL 462
+ E S +V LK K+E + + L+ + + K +T ++ E++ +L
Sbjct: 2352 QEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISEL 2411
Query: 463 EIMPSS-EAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKN-------------- 507
EI+ SS E EK +QE Q+KE+ Q LK N
Sbjct: 2412 EIINSSFENILQEK------EQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACK 2465
Query: 508 TKDGNLGK-----ELEAAQ--EQLAELKEKYISLRLSCEELEHQHQQEADDWKQELAR-- 558
K+ NL ELE AQ + L E K YI L+ S L QE +D KQ+L +
Sbjct: 2466 AKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGL----IQEVEDGKQKLEKKD 2521
Query: 559 --LQQLHRQELERCQLDFRDRTLKLEEELHKQRD---RALAVLTEKDLELEQLRSVALAS 613
+ +L Q ++ QL + ++ E +L K+++ R L V E+ +++ Q ++ +L
Sbjct: 2522 EEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQD 2581
Query: 614 GLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQ 673
L + SS +L L+L ++ +F ++ KE T L+++
Sbjct: 2582 TLEVLQ--------------SSYKNLENELELTKMDKMSFVEKVNKMTAKE---TELQRE 2624
Query: 674 KHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQSRE 716
H + + +LQ+ L E R E+ L I K+ +DQ +E
Sbjct: 2625 MHEMAQKTAELQEELSGEKNRLAGELQLLLEEI-KSSKDQLKE 2666
Score = 76.6 bits (187), Expect = 8e-14
Identities = 96/445 (21%), Positives = 202/445 (45%), Gaps = 58/445 (13%)
Query: 195 QDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQH-DRAQEQSDHALMLRELQKL 253
+DL++ NK EER RLE E+K LQ + A T H D A+ Q+ ++ + +K
Sbjct: 165 EDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKT 224
Query: 254 LQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTRE----------VEELK 303
+ Q +R + + +G ++ + +++LK
Sbjct: 225 PSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLK 284
Query: 304 SELQAIRDEKNQPDPRLQELQEEAARLKSHFQ-AQLQQEMRKTALAEDQLRQQSQVEEQR 362
++ Q +R++ N+ + RLQ ++E + FQ QLQ E K L +E+++
Sbjct: 285 AQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVEL----------IEKEK 334
Query: 363 VAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHG 422
V L E+ Y++A K QKLK+ L + + A S+R L+
Sbjct: 335 V--LNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQN---AESARCSLEQKI 389
Query: 423 EESSLDVNVLKDKMEKLKRLLQVAAR-----KSQVTLDVEKLCDLEIMPSSEAADGEKAT 477
+E + ++++ + +R Q + K+++T ++++ ++ + +E +K T
Sbjct: 390 KEKEKE---FQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAEL---DKLT 443
Query: 478 ALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEK------- 530
++ +Q+L+ EEF++ RA+ ++ K+ L + +E +++ LK
Sbjct: 444 SV--KQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKARE 501
Query: 531 --YISLRL-SCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEE---- 583
++ L + ++ +Q Q A++ K + + + R E+ ++ ++ +L LE+
Sbjct: 502 VCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEK--INQQENSLTLEKLKLA 559
Query: 584 --ELHKQRDRALAVLTEKDLELEQL 606
+L KQRD + +L +++ +EQL
Sbjct: 560 VADLEKQRDCSQDLLKKREHHIEQL 584
Score = 76.6 bits (187), Expect = 8e-14
Identities = 114/576 (19%), Positives = 243/576 (42%), Gaps = 55/576 (9%)
Query: 160 QLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQ 219
Q T+ L L +T++ S + + + ++Q +++ + +EE +R + + L
Sbjct: 352 QASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLD 411
Query: 220 EQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRA 279
++ + KARL TQ+ +A+ H ++ EL KL + +Q LE LEE ++ L
Sbjct: 412 QECIQMKARL-TQELQQAKNM--HNVLQAELDKL----TSVKQQLENNLEEFKQKL---C 461
Query: 280 YAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKS--HFQAQ 337
A + + +++ +L R +EE+K E ++ Q + L+ E +K +
Sbjct: 462 RAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQN 521
Query: 338 LQQEMR-KTALAEDQLRQ-QSQVEEQR----VAALENQISEVSELLGTYEKAKQKDQLAI 391
+EM+ K E LR Q ++ +Q + L+ ++++ + + +K + I
Sbjct: 522 FAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHI 581
Query: 392 QKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKSQ 451
++L +++ + + E+K L A + +E + K + EKL L Q+ + K
Sbjct: 582 EQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKL--LTQMESEKEN 639
Query: 452 VTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDG 511
+ K+ LE ++ + Y + ++ L E +R + ++
Sbjct: 640 LQ---SKINHLETCLKTQQIKSHE-----YNERVRTL--EMDRENLSVEI---------R 680
Query: 512 NLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDW----KQELARLQQL-HRQE 566
NL L++ ++ K Y+ L+ E + +HQ+E ++ Q +++ L H+ +
Sbjct: 681 NLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQ 740
Query: 567 LERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLEL----EQLRSVALASGLPGRR--- 619
L ++ +DR ++LH + + +L KD L + RS+ P
Sbjct: 741 LLSNEIMDKDRCY---QDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSF 797
Query: 620 -SPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLE 678
+ +G G + Q+ + +A + L ++ + L+KQ L
Sbjct: 798 ANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELV 857
Query: 679 VEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQS 714
++++ L++ + H+ VA I K D S
Sbjct: 858 QIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTS 893
Score = 75.5 bits (184), Expect = 2e-13
Identities = 113/487 (23%), Positives = 215/487 (44%), Gaps = 53/487 (10%)
Query: 160 QLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQ 219
Q+K + T L +E + A+ D++ MK + EEE +L ++ L+
Sbjct: 2249 QIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEH-QLRNSIEKLR 2307
Query: 220 EQI-AETKARLITQQHDRAQEQSDHALMLR----ELQKLLQEERTQRQDLELRLEETREA 274
++ A+ K +L Q + +E HA +L+ L++ L+ RT ++ L E ++
Sbjct: 2308 ARLEADEKKQLCVLQ--QLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGE 2365
Query: 275 LAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHF 334
+ ++EG + L +V ++SE + + +E + R+ EL+ + ++
Sbjct: 2366 VET---LKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENIL 2422
Query: 335 QAQLQQEMR---KTALAEDQLRQQSQVEEQRVAALEN----------QISEVSELLGTYE 381
Q + Q++++ K++ A + L+ Q + +RVAAL N +S E L E
Sbjct: 2423 QEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECL-ELE 2481
Query: 382 KAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKR 441
KA+ L K +LQ + N + + L+ EE S N ++D+ + + +
Sbjct: 2482 KAQLLQGLDEAKNNYIVLQSSV-NGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSK 2540
Query: 442 LLQVAAR----KSQ----VTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFE 493
L QV K Q L VE ++++ S A+ + L Q K L+ E E
Sbjct: 2541 LSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVL--QSSYKNLENELE 2598
Query: 494 RYKMRAQVVLKSKN---TKDGNLGKELEAAQEQLAELKEKYI--------SLRLSCEELE 542
KM ++ N K+ L +E+ ++ AEL+E+ L+L EE++
Sbjct: 2599 LTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIK 2658
Query: 543 HQHQQ--EADDWKQELAR-LQQLHRQELERCQLDFRDRTLKLEEELH--KQRDRALAVLT 597
Q E EL + L +H+ ++E+ + R+ + + LH +++ +AL + T
Sbjct: 2659 SSKDQLKELTLENSELKKSLDCMHKDQVEK-EGKVREEIAEYQLRLHEAEKKHQALLLDT 2717
Query: 598 EKDLELE 604
K E+E
Sbjct: 2718 NKQYEVE 2724
Score = 74.3 bits (181), Expect = 4e-13
Identities = 116/580 (20%), Positives = 237/580 (40%), Gaps = 99/580 (17%)
Query: 196 DLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQ 255
D+E+ ++ E+A +E E L+ + + + + D +Q + EL +
Sbjct: 1899 DVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTS 1958
Query: 256 EERTQRQDL--------------ELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEE 301
E R +L E E+T+E + ++ ++ E + K+ T ++
Sbjct: 1959 ERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQT 2018
Query: 302 LKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQ 361
L S++ + +K +LQ L++++ L S + +L+ ++ + ++ L ++S+ +
Sbjct: 2019 LSSDVSELLKDKTHLQEKLQSLEKDSQAL-SLTKCELENQIAQLNKEKELLVKESESLQA 2077
Query: 362 RVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQL--DLENKTLALAASSRSPLD 419
R++ + + VS+ L K + L + +E + QL +E + + A + L
Sbjct: 2078 RLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLH 2137
Query: 420 --SHGEESSLDVNVLKDKMEKLKRLLQVAARKSQ-VTLDVEKLCDLEIMPSSEAADGEKA 476
+E + + LKDK+E L+R LQ++ + V LD A+ KA
Sbjct: 2138 IAEKLKERERENDSLKDKVENLERELQMSEENQELVILD---------------AENSKA 2182
Query: 477 TALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRL 536
+ LK EE R ++ L + ++ NL K+++ Q QL+EL + S +
Sbjct: 2183 EV----ETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKS 2238
Query: 537 SCEELEHQHQQEADDWKQELARLQQLHR------------QELERCQLDFRDRTLKLEEE 584
EE E Q ++ K + LQ + QE+ + D ++ E +
Sbjct: 2239 LLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQ 2298
Query: 585 LHKQRDRALAVLTEKDLE----LEQLR-SVALASGLPGRRSPVGGGGPGDPADTSSSDSL 639
L ++ A L + + L+QL+ S A L GR ++L
Sbjct: 2299 LRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGR-----------------VENL 2341
Query: 640 TQALQLAAANEPTFFLYAE------------------QLARKEVEITSLRKQKHRLEVEV 681
+ L++A N+ L AE L E+++ ++R +K L E+
Sbjct: 2342 ERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNEL 2401
Query: 682 HQLQDRLLEEGERHREEVAALQSHIEKNIRDQSREGANLE 721
+ Q+R+ E+ + S E ++++ +E ++
Sbjct: 2402 QKEQERI--------SELEIINSSFENILQEKEQEKVQMK 2433
Score = 72.4 bits (176), Expect = 1e-12
Identities = 126/616 (20%), Positives = 266/616 (43%), Gaps = 97/616 (15%)
Query: 14 KKDLLETIETQKKQLLQYQARLKDVVRAYKSLLKEKEALEASIKVLSVSHEADVGLAGVQ 73
K++L + I+ ++ QL + L ++ ++KSLL+EKE E IK S + V + Q
Sbjct: 2212 KENLTKQIQEKQGQL----SELDKLLSSFKSLLEEKEQAEIQIKEES---KTAVEMLQNQ 2264
Query: 74 LPGLTFPDSVDDRCSTHSEDSTGTATSLDTAASLTSTKGEFGVEDDRPARGPPPP---KS 130
L L ++V C E T SLD +E++ R +
Sbjct: 2265 LKELN--EAVAALCGDQ-EIMKATEQSLDPP-----------IEEEHQLRNSIEKLRARL 2310
Query: 131 EEASWSESGVSSSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADK 190
E + V + + R+ L+ +L +A QE + +EA
Sbjct: 2311 EADEKKQLCVLQQLKESEHHADLLKGRVENLEREL-----EIARTNQEHAALEA------ 2359
Query: 191 KKMKQDLEDASNKAEEERARLEG---ELKGLQEQIAETKARL--ITQQHDRAQEQ-SDHA 244
E++ + E +A++EG L+GL+ + ++ +T + + QE+ S+
Sbjct: 2360 -------ENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELE 2412
Query: 245 LMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKS 304
++ + +LQE+ ++ ++ + ++ ME + Q K+L V L +
Sbjct: 2413 IINSSFENILQEKEQEKVQMKEK-------------SSTAMEMLQTQLKELNERVAALHN 2459
Query: 305 ELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQ------LQQEMRKTALAEDQLRQQSQV 358
+ +A + ++ +++ L+ E A+L LQ + + +Q+ +
Sbjct: 2460 DQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEK 2519
Query: 359 EEQRVAALENQISEVSELLGTYEKAKQKDQL-AIQKLKERILQLDLENKTLALAASSRSP 417
+++ ++ L+NQI + +L+ + + + QL Q L+ R L ++LE K L + + S
Sbjct: 2520 KDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASL 2579
Query: 418 LDSHGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKAT 477
D+ + VL+ + L+ L++ ++K+ +E + A + E
Sbjct: 2580 QDT--------LEVLQSSYKNLENELELTK--------MDKMSFVEKVNKMTAKETELQR 2623
Query: 478 ALYYQ-QELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRL 536
++ Q+ +L+EE K R L+ L +E++++++QL EL + L+
Sbjct: 2624 EMHEMAQKTAELQEELSGEKNRLAGELQL-------LLEEIKSSKDQLKELTLENSELKK 2676
Query: 537 SCEELEHQHQQEADDWKQELARLQ-QLHRQELERCQLDFRDRTLKLEEELHKQRDRALA- 594
S + + ++ ++E+A Q +LH E ++ Q D + E E+ R++ +
Sbjct: 2677 SLDCMHKDQVEKEGKVREEIAEYQLRLHEAE-KKHQALLLDTNKQYEVEIQTYREKLTSK 2735
Query: 595 --VLTEKDLELEQLRS 608
L+ + LE++ L+S
Sbjct: 2736 EECLSSQKLEIDLLKS 2751
Score = 71.2 bits (173), Expect = 3e-12
Identities = 94/414 (22%), Positives = 182/414 (43%), Gaps = 41/414 (9%)
Query: 161 LKTQLATLTSSLATVTQEKSRMEASYLADKKKMK---QDLEDASNKAE---EERARLEGE 214
L +Q+ L A + Q + +Y+ + + Q++ED K E EE +RL+ +
Sbjct: 2471 LSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQ 2530
Query: 215 LKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREA 274
++ QEQ+ +K + +H +EQ+ L LR L L+++ Q L++T E
Sbjct: 2531 IQD-QEQLV-SKLSQVEGEHQLWKEQN---LELRNLTVELEQKIQVLQSKNASLQDTLEV 2585
Query: 275 LAGRAYAAE-QMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSH 333
L E ++E ++ +V ++ ++ ++ E ++ + ELQEE + K+
Sbjct: 2586 LQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNR 2645
Query: 334 FQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQK 393
+LQ + + ++DQL++ + + +L+ + E G + + QL + +
Sbjct: 2646 LAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHE 2705
Query: 394 L--KERILQLDLENKTLALAASSRSPLDSHGE---ESSLDVNVLKDKMEK----LKRLLQ 444
K + L LD + + R L S E L++++LK E+ LK Q
Sbjct: 2706 AEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQ 2765
Query: 445 VAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFE----------- 493
+ + +D K + ++ +E A G+ + + KQL+EE E
Sbjct: 2766 ILEELKKTKMDNLKYVN-QLKKENERAQGKMKLLI---KSCKQLEEEKEILQKELSQLQA 2821
Query: 494 -RYKMRAQVVLKSK----NTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELE 542
+ K + V+ +K T+ L + LE ++ E +KY SL +S E+LE
Sbjct: 2822 AQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLE 2875
Score = 62.8 bits (151), Expect = 1e-09
Identities = 95/440 (21%), Positives = 206/440 (46%), Gaps = 37/440 (8%)
Query: 176 TQEKSRMEASYLADKKKMKQDLEDASN-----KAEEER--ARLEGELKGLQEQIAETKAR 228
T+++S+ S L KKK ++L++ K+E E+ ++E E + LQ +I +
Sbjct: 591 TEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETC 650
Query: 229 LITQQ------HDRAQ----EQSDHALMLRELQKLLQEERTQRQDLELR-LEETREALAG 277
L TQQ ++R + ++ + ++ +R L +L + + + +L +E ++A
Sbjct: 651 LKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFS 710
Query: 278 RAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQ 337
+++E L+T QLT +VE+L+ +LQ + +E D Q+L E L+ ++
Sbjct: 711 DQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKS- 769
Query: 338 LQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKER 397
+ +L ++ Q+S + + A+ + + + G+ + + +L + +
Sbjct: 770 -----KDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKN 824
Query: 398 ILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEK-LKRLLQVAARKSQVTLDV 456
L +L + S+ ++S ++ ++ +K ++E+ L + Q+ +S V
Sbjct: 825 SAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQM--HQSFVAETS 882
Query: 457 EKLCDL-EIMPSSEAADGEKATAL-YYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLG 514
+++ L E + + E +AL ++EL+ L ++ E + Q + KS + + +L
Sbjct: 883 QRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSL- 941
Query: 515 KELEAAQEQLA-ELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQ-----LHRQELE 568
KEL+ E L+ E KE + L+ E+E + QE K+ A L Q + + E
Sbjct: 942 KELQLLSETLSLEKKEMSSIISLNKREIE-ELTQENGTLKEINASLNQEKMNLIQKSESF 1000
Query: 569 RCQLDFRDRTLKLEEELHKQ 588
+D R++++ + +KQ
Sbjct: 1001 ANYIDEREKSISELSDQYKQ 1020
Score = 61.6 bits (148), Expect = 3e-09
Identities = 122/589 (20%), Positives = 231/589 (39%), Gaps = 104/589 (17%)
Query: 155 DKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERAR---L 211
+ L + ++ + L + +++K+R A+ K +KQ L + N AEE +A+
Sbjct: 474 ENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQ 533
Query: 212 EGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKL---LQEERTQRQDLELRL 268
E L+ LQE+I Q +++L L +L+ L+++R QDL +
Sbjct: 534 ETMLRDLQEKI----------------NQQENSLTLEKLKLAVADLEKQRDCSQDLLKKR 577
Query: 269 EETREALAGRAYAAEQMEGFELQTKQL-TREVEELKSELQAIRDEKNQPDPRLQELQEEA 327
E E L + E+ L +L +E EELK E K++ + L +++ E
Sbjct: 578 EHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEK 637
Query: 328 ARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAAL--ENQISEVSELLGTYEKAKQ 385
L+S +T L Q++ E R + EN E+ L
Sbjct: 638 ENLQSKI------NHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVL----- 686
Query: 386 KDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQV 445
D +++ +++ ++L+ K A S E L + L ++E L+ LQ+
Sbjct: 687 -DSKSVEVETQKLAYMELQQK----AEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQL 741
Query: 446 AARK--------SQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKM 497
+ + + + E L DL ++ D T +Q+ L ++ +
Sbjct: 742 LSNEIMDKDRCYQDLHAEYESLRDL-----LKSKDASLVTNEDHQRSLLAFDQQPAMHHS 796
Query: 498 RAQVVLKSKNTKDGNLGKELEAAQ--EQLAELKEKYISLRLSCEELEHQHQQEADDWKQ- 554
A ++ + + LEA Q + A L+ + SL S LE Q Q +D KQ
Sbjct: 797 FANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFS---LESQKQMNSDLQKQC 853
Query: 555 -ELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALAS 613
EL +++ ++EE L K + + E + +L+
Sbjct: 854 EELVQIKG------------------EIEENLMKAEQMHQSFVAETSQRISKLQE----- 890
Query: 614 GLPGRRSPVGGGGPGDPADTSSSDS-LTQALQLAAANEPTFFLYAEQLARKEVEITSLRK 672
DTS+ + + + L E L +++ ++ EI L+K
Sbjct: 891 ------------------DTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKK 932
Query: 673 QKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQSREGANLE 721
H LE + +LQ L E ++E++++ S ++ I + ++E L+
Sbjct: 933 SNHLLEDSLKELQ-LLSETLSLEKKEMSSIISLNKREIEELTQENGTLK 980
Score = 53.9 bits (128), Expect = 6e-07
Identities = 122/612 (19%), Positives = 246/612 (40%), Gaps = 107/612 (17%)
Query: 129 KSEEASWSESGVSSSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLA 188
KS E + F+ + K + + + + LT + + + K ++ ++ +
Sbjct: 689 KSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDL-EHKLQLLSNEIM 747
Query: 189 DKKKMKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQ-HDRAQEQSDHA-LM 246
DK + QDL E + L++ + A L+T + H R+ D M
Sbjct: 748 DKDRCYQDLH--------------AEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAM 793
Query: 247 LRELQKLLQEERT---QRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELK 303
++ E+ + +R + L +++ + A + +E F L++++ ++
Sbjct: 794 HHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLE-FSLESQK------QMN 846
Query: 304 SELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRV 363
S+LQ +E Q ++E +A ++ F A+ Q + K L ED Q+ V E +
Sbjct: 847 SDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISK--LQEDTSAHQNVVAET-L 903
Query: 364 AALENQISEVSELLGTYEKAKQKDQLAIQK----LKERILQLDLENKTLALAASSRSPLD 419
+ALEN+ E+ +LL + +Q + ++K L++ + +L L ++TL+L S +
Sbjct: 904 SALENKEKEL-QLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSII 962
Query: 420 S------------HGEESSLDVNVLKDKM--------------EKLKRLLQVAARKSQVT 453
S +G ++ ++ ++KM E+ K + +++ + Q
Sbjct: 963 SLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEK 1022
Query: 454 LDVEKLCD-----LEIMPSSEAADGEKATALYY------------QQELKQLKEEFERYK 496
L + + C+ E + A EK + L + EL+QLKE F +
Sbjct: 1023 LILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEH 1082
Query: 497 MRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQEL 556
L ++ NL ELE Q+ +LR + ++ + EA KQE+
Sbjct: 1083 QEFLTKLAFAEERNQNLMLELETVQQ----------ALRSEMTDNQNNSKSEAGGLKQEI 1132
Query: 557 ARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLP 616
L ++E + Q + D L ++ ++ + V+ K E + L S + + +
Sbjct: 1133 MTL----KEEQNKMQKEVND--------LLQENEQLMKVMKTKH-ECQNLESEPIRNSVK 1179
Query: 617 GRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHR 676
R S D + + L + N L A L KE+++ K+K
Sbjct: 1180 ERESE-----RNQCNFKPQMDLEVKEISLDSYNAQLVQLEA-MLRNKELKLQESEKEKEC 1233
Query: 677 LEVEVHQLQDRL 688
L+ E+ ++ L
Sbjct: 1234 LQHELQTIRGDL 1245
Score = 47.0 bits (110), Expect = 7e-05
Identities = 92/480 (19%), Positives = 197/480 (41%), Gaps = 84/480 (17%)
Query: 156 KRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGEL 215
+++ +L+ QL L + +EA+ K+K++ + + +N E + +E
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLME--- 74
Query: 216 KGLQEQIAETKARLITQQHDRAQEQSDHALML----RELQKLLQEERTQRQDLELRLEET 271
+ E + +TK ++ + + + + L ++++KL QE + + +LE +
Sbjct: 75 --ICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAA 132
Query: 272 REA------------------LAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEK 313
+ A + Y+ + E + + + E + L++E++A++ +K
Sbjct: 133 QSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKK 192
Query: 314 -NQPDPRLQELQEEAARLKSHFQA-QLQQEMRKTALAEDQLRQQSQVEEQRVAALENQIS 371
+Q P+ + AR ++ QQE + L+ + Q++ + A+ +
Sbjct: 193 ASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNS--QRTPIRRDFSASYFSGEQ 250
Query: 372 EVSELLGTYEKAKQK---------------DQLAI--QKLKERILQLDLENKTLALAASS 414
EV+ T + K+ DQL Q+L+ +I +L+L
Sbjct: 251 EVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELR---------- 300
Query: 415 RSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTL-DVEKL---CDLEIMPSSEA 470
L H +E VN ++ LQ+ K++V L + EK+ C E++ ++
Sbjct: 301 ---LQGHEKEMKGQVNKFQE--------LQLQLEKAKVELIEKEKVLNKCRDELVRTTAQ 349
Query: 471 ADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEK 530
D +Q+LK+L E+ + A+ S K KE QE+L+ +
Sbjct: 350 YDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEF---QEELSRQQRS 406
Query: 531 YISLRLSCEELEHQHQQEADDWKQ-------ELARLQQLHRQELERCQLDFRDRTLKLEE 583
+ +L C +++ + QE K EL +L + +Q+LE +F+ + + E+
Sbjct: 407 FQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSV-KQQLENNLEEFKQKLCRAEQ 465
Score = 42.4 bits (98), Expect = 0.002
Identities = 95/476 (19%), Positives = 192/476 (40%), Gaps = 61/476 (12%)
Query: 164 QLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQEQIA 223
QL + + QE + + + + ++ DLE ++ + + + E+ GL++
Sbjct: 1212 QLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQ-----EISGLKDCEI 1266
Query: 224 ETKARLITQQHDRAQEQSDHALM----------LRELQKLLQEERTQRQDLELRLEETR- 272
+ + + I+ H+ + Q+D+A + L EL+K+ + + ++ +L L ++R
Sbjct: 1267 DAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRS 1326
Query: 273 EALAGRAYAAEQMEGFELQTKQLTREVEELKSELQA------IRDEKNQPDPRLQELQEE 326
E + AE++ + K L + L EL ++ N+ P +E
Sbjct: 1327 ECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDE 1386
Query: 327 AARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQK 386
+ + + + +M L E L QS E + + Q+S L TY + +
Sbjct: 1387 SNSYEHLTLSDKEVQMHFAELQEKFLSLQS--EHKILHDQHCQMSSKMSELQTYVDSLKA 1444
Query: 387 DQLAIQK---------LKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKME 437
+ L + +KE +QL LE + +SS P DS S D + + +E
Sbjct: 1445 ENLVLSTNLRNFQGDLVKE--MQLGLEEGLVPSLSSSCVP-DSSSLSSLGDSSFYRALLE 1501
Query: 438 KLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKM 497
+ T D+ L +LE S+ ++ Q+E KE
Sbjct: 1502 Q--------------TGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSA--- 1544
Query: 498 RAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELA 557
+K ++ L E ++ L +L+EK S + + + +Q +QEL
Sbjct: 1545 ------PAKGVEE--LESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELD 1596
Query: 558 RLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALAS 613
L++ + E E+ Q TL++E +L ++ + + E ++ QL+ + L+S
Sbjct: 1597 CLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSS 1652
Score = 30.4 bits (67), Expect = 6.5
Identities = 15/52 (28%), Positives = 30/52 (57%)
Query: 13 SKKDLLETIETQKKQLLQYQARLKDVVRAYKSLLKEKEALEASIKVLSVSHE 64
+K D L+ + KK+ + Q ++K ++++ K L +EKE L+ + L + E
Sbjct: 2773 TKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQE 2824
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 90.5 bits (223), Expect = 5e-18
Identities = 158/794 (19%), Positives = 320/794 (40%), Gaps = 83/794 (10%)
Query: 14 KKDLLETIETQKKQLLQYQARLKDVVRAYKSLLKEKEALEASIKVLSVSHEADVGLAGVQ 73
K +L E I +K+ Q Q +L++ + + K++LK+ + E ++ + D Q
Sbjct: 1159 KPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQ 1218
Query: 74 LPGLTFP-DSVDDRCSTHS----EDSTGTATSLDTAASLTSTKGEFGVEDDRPARGPPPP 128
+ +++ D+ E G S D S +ST G + P
Sbjct: 1219 FDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQP 1278
Query: 129 KSEE---ASWSESGVSSSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKSRM-EA 184
E W +S+ G + ++ +L +++ + L +++ T E ++ E
Sbjct: 1279 VLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEE 1338
Query: 185 SYLADKKKMKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHA 244
+ ++ KQ LE S K A + E LQ+++ ++ ++ +H R +
Sbjct: 1339 VFQLQEQINKQGLEIESLKTVSHEAEVHAE--SLQQKLESSQLQIAGLEHLRELQPK--- 1393
Query: 245 LMLRELQKLLQEERTQRQDLELRLEETREALAG-RAYAAEQMEGFELQTKQLTREVEELK 303
L ELQKL+ ++ L +L E AL + EQ + + QL + +E
Sbjct: 1394 --LDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHD 1451
Query: 304 SELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEM--RKTALAEDQ-LRQQSQVEE 360
++ ++ E + + +E+ EE+ R K Q +LQ + RK AL E++ L+++ +
Sbjct: 1452 ERIKQLQVELCEMKQKPEEIGEES-RAKQQIQRKLQAALISRKEALKENKSLQEELSLAR 1510
Query: 361 QRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDS 420
+ L +++V + K K D LAL R L +
Sbjct: 1511 GTIERLTKSLADVESQVSAQNKEK-----------------DTVLGRLALLQEERDKLIT 1553
Query: 421 HGEESSLDVNVLKDKMEKLKRLLQ-VAARKSQVTLDVEKLCDLEIMPSSEAADGEKATAL 479
+ S L+ L E LK L+ + K ++ ++E L +I S+E + K
Sbjct: 1554 EMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQK 1613
Query: 480 YYQ---QELKQLKEEFERYKMRAQVVLKSKNTKDGNLG----------KELEAAQEQLAE 526
Y+ Q + + E ER + + V + K G L K+L+ A++++ E
Sbjct: 1614 EYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEE 1673
Query: 527 LKEKYISLRLSCE----ELEHQHQQ----------EADDWKQELARLQQLHRQELERCQL 572
+KEK S + ELE ++ + A + + L ++ELER ++
Sbjct: 1674 MKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKM 1733
Query: 573 DFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGL------PGRRSPVGGGG 626
++ + K + + ++ + V +DL+ + +V+ + L + + G
Sbjct: 1734 EYETLSKKFQSLMSEKDSLSEEV---QDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGT 1790
Query: 627 PGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQLQD 686
P +T DSL+ + + + A K+ S + + ++ QL++
Sbjct: 1791 QSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDF---SSHDEINNYLQQIDQLKE 1847
Query: 687 R---LLEEGERHREEVAALQSHIEKNIRDQSREGANLEYLKNIIYRFLTLPDSLGRQQTL 743
R L EE ++++E L++ + S + L+ L+ + + L + Q+ L
Sbjct: 1848 RIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQI--QEEL 1905
Query: 744 TAILTILHFSPEEK 757
+ + + + EEK
Sbjct: 1906 SRVTKLKETAEEEK 1919
Score = 82.8 bits (203), Expect = 1e-15
Identities = 122/664 (18%), Positives = 260/664 (39%), Gaps = 104/664 (15%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQE------KSRMEASYLADKKKMKQDLEDASNKAEE 206
E D +L QLA L S+ Q+ K+ + S + + KK +LE+ + +
Sbjct: 1918 EKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVK 1977
Query: 207 ERARLEGEL---------------------KGLQEQIAETKARLITQQHDRAQEQSDHAL 245
E+ ++E E+ K LQE + E + + Q D + Q +
Sbjct: 1978 EKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISA 2037
Query: 246 MLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREV------ 299
+ R ++ L + ++DLE+ E +A+ R A ++ F++ E
Sbjct: 2038 LERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLAD 2097
Query: 300 -----EELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQ 354
+EL+S ++++ + Q D L+ E+A + H + + + + AL +++
Sbjct: 2098 NLKLKKELQSNKESVKSQMKQKDEDLERRLEQAE--EKHLKEKKNMQEKLDALRREKVHL 2155
Query: 355 QSQVEEQRVAA--LENQISEVSELLG---TYEKAKQKDQLAIQKLKERILQ--------- 400
+ + E +V + ++ ++ E L T A K ++Q ++R++
Sbjct: 2156 EETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKF 2215
Query: 401 ---LDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVE 457
+ + + + L + S L + S+ + LK + +L+ Q+ K+Q + ++
Sbjct: 2216 SDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQ 2275
Query: 458 -KLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKE 516
K+CD GE L +E + L + + + LKS + +L
Sbjct: 2276 QKVCD--------TLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNS 2327
Query: 517 LEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQ----- 571
LE +EQ L+ + + ++Q D + +LH + + Q
Sbjct: 2328 LEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISL 2387
Query: 572 LDFRDRTLKLE-EELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDP 630
L ++ +++ EL +Q D+ + L E L E+ ++ L +
Sbjct: 2388 LSGKEEAIQVAIAELRQQHDKEIKEL-ENLLSQEEEENIVL-----------------EE 2429
Query: 631 ADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQLQDRLLE 690
+ + D Q ++ + QL ++SL+ + R+ + QL++R L
Sbjct: 2430 ENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLS 2489
Query: 691 --------------EGERHREEVAALQSHIEKNIRDQSREGANLEYLKNIIYRFLTLPDS 736
E + +EE+ L+SH++ + ++ A L + + + +T+ DS
Sbjct: 2490 IILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDS 2549
Query: 737 LGRQ 740
+Q
Sbjct: 2550 QQKQ 2553
Score = 71.6 bits (174), Expect = 3e-12
Identities = 129/614 (21%), Positives = 255/614 (41%), Gaps = 80/614 (13%)
Query: 162 KTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQEQ 221
K + TL SS A++ +E R++ Y KK Q L + EE L+ +++G +
Sbjct: 1711 KECMETLLSSNASMKEELERVKMEYETLSKKF-QSLMSEKDSLSEEVQDLKHQIEGNVSK 1769
Query: 222 IAETKARLITQQHDRAQEQSDHALM-----LRELQKLLQEERTQRQDLELRLEETREALA 276
A +A T++HD ++ E L R + + A++
Sbjct: 1770 QANLEA---TEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVS 1826
Query: 277 GRAYAAEQMEGFELQTKQLTREVEELKSELQ-------AIRDEKNQ-------PDPRLQE 322
+ +++ + Q QL + L+ E Q + +EKN D L+
Sbjct: 1827 KDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKM 1886
Query: 323 LQEEAARLKSHFQAQLQQEM-RKTALAEDQLRQQSQVEEQRVAALENQISEVSELLGTYE 381
LQEE ++ + Q+Q+E+ R T L E ++ +EE+ L NQ++E++ +G Y
Sbjct: 1887 LQEEVTKM-NLLNQQIQEELSRVTKLKETAEEEKDDLEER----LMNQLAELNGSIGNY- 1940
Query: 382 KAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKL-- 439
+ ++K +L+ +++N ++ E++ ++ + K+ +EK+
Sbjct: 1941 ----CQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQG 1996
Query: 440 -----------KRLLQVAARKSQVTLDVEKLC---DLEIMPSSEAADGEKATALYYQQEL 485
K L ++ K Q ++K C +I + Q++L
Sbjct: 1997 AQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDL 2056
Query: 486 KQLKEEFER---YKMRAQVVLKS-KNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEEL 541
+ KE + ++ +AQ L S K D + EAA+ LK K L+ + E +
Sbjct: 2057 EITKENLAQAVEHRKKAQAELASFKVLLDDT---QSEAARVLADNLKLKK-ELQSNKESV 2112
Query: 542 EHQHQQEADDWKQELARLQQLHRQELERCQ--LD-FRDRTLKLEEELHKQRDRALAVLTE 598
+ Q +Q+ +D ++ L + ++ H +E + Q LD R + LEE + + + L +
Sbjct: 2113 KSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQ----VTLNK 2168
Query: 599 KDLELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFF---- 654
KD E++QL+ S V + +S D + + A E F
Sbjct: 2169 KDKEVQQLQE--------NLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQ 2220
Query: 655 LYAEQLARKEVEITSLRKQKHRLEVEVHQLQDRL--LEEGERHREEVAALQSHIEKNIRD 712
E++ KE + L+ Q ++ + + +L+ + LE ++ E A + +++ + D
Sbjct: 2221 SKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCD 2280
Query: 713 QSREGANLEYLKNI 726
+ +G N E L +
Sbjct: 2281 -TLQGENKELLSQL 2293
Score = 68.9 bits (167), Expect = 2e-11
Identities = 126/628 (20%), Positives = 253/628 (40%), Gaps = 86/628 (13%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLE 212
E RLH+ + + + T Q+K R+ L + ++ + ++E E
Sbjct: 227 ETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAE 286
Query: 213 GELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQ----RQDLELRL 268
+ L +Q+ + +A T ++ E+ + ++L +++ + E + ++++ L
Sbjct: 287 QRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLL 346
Query: 269 EETREA------LAGRAYAAEQMEGFELQTK-----QLTREVEELKSELQAIRDEKN--- 314
E+ +A L R A EQ E++ K L + +EL+S A++D+ +
Sbjct: 347 EQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLL 406
Query: 315 ---------------QPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVE 359
Q + +LQ+ +E ++ + Q + +T+ + V
Sbjct: 407 QDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVT 466
Query: 360 EQRVAALENQISEVSE-----LLGTYEKAKQKDQLAIQKLKERILQLDLENKT------- 407
E+ +A+L+ ++ E+ LL + E + K + +KL +I L+ +N+T
Sbjct: 467 EENIASLQKRVVELENEKGALLLSSIELEELKAE--NEKLSSQITLLEAQNRTGEADREV 524
Query: 408 ----LALAASSRSPLDSHGEESSLDV--NVLKDKMEKLKRLLQVAARKSQVTLDVEKLCD 461
+ A+ RS S EES DV N K ++L LL + +++Q E++
Sbjct: 525 SEISIVDIANKRS---SSAEESGQDVLENTFSQKHKELSVLL-LEMKEAQ-----EEIAF 575
Query: 462 LEIMPSSEAADGEKATALYYQQELKQLK-EEFERYKMR------AQVVLKSKNTKDGNLG 514
L++ + A+ E + Q+E+KQ++ E KM+ Q N +
Sbjct: 576 LKLQLQGKRAE-EADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPA 634
Query: 515 KELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDF 574
E E A + + ISL + EL+ +Q+ D + + Q H+ ELER
Sbjct: 635 VEKEQASTEHQSRTSEEISLNDAGVELK-STKQDGDKSLSAVPDIGQCHQDELER----L 689
Query: 575 RDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPADTS 634
+ + L+LE HK ++ L EK E+ L + +++
Sbjct: 690 KSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEF----KKNADNNSSAFTALSEE 745
Query: 635 SSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGER 694
L+Q +L+ E Q+ + E+ + +Q+ RL+ E D LL E +
Sbjct: 746 RDQLLSQVKELSMVTE-----LRAQVKQLEMNLAEAERQR-RLDYESQTAHDNLLTE-QI 798
Query: 695 HREEVAALQSHIEKNIRDQSREGANLEY 722
H + A ++ + + L++
Sbjct: 799 HSLSIEAKSKDVKIEVLQNELDDVQLQF 826
Score = 67.8 bits (164), Expect = 4e-11
Identities = 137/704 (19%), Positives = 276/704 (39%), Gaps = 112/704 (15%)
Query: 17 LLETIETQKKQLLQYQARLKDVVRAYKSLLKEKEALEASIKVLSVSH-----EADVGLAG 71
L+ET++T KK+ +Q +A+L V++ SL +++ + + L H E D +
Sbjct: 2441 LMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQE 2500
Query: 72 VQLPGLTFPDSVDDRCSTHSEDSTGTATSLDTAASLTSTKGEFG----VEDDRPAR--GP 125
+ + +H +D LD A L + + ++D + +
Sbjct: 2501 AAAENNKLKEEIRG-LRSHMDDLNSENAKLD--AELIQYREDLNQVITIKDSQQKQLLEV 2557
Query: 126 PPPKSEEASWSESGVSSSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKSRMEAS 185
+++E + + + A ++ + + L+ + L+ + ++ S++
Sbjct: 2558 QLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQ 2617
Query: 186 YLADKKKMKQDLEDASNKAEEERA-RLEGELKGLQEQIAETKARLITQQHDRAQEQSDHA 244
A +++ L A K +EE RL Q++IAE + L+ Q + A++ +
Sbjct: 2618 VTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIE 2677
Query: 245 LMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKS 304
KL +E + D + ET A A A + E + +T+E + L +
Sbjct: 2678 ------DKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTA 2731
Query: 305 ELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVA 364
++Q+ + EE LK + A L++ LA QL++Q + +R A
Sbjct: 2732 QIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKE------LA--QLKEQGLLNRERDA 2783
Query: 365 ALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEE 424
L SE + ++ ++KL +++L D + L S DS+ +
Sbjct: 2784 LL-------SETAFSMNSTEENSLSHLEKLNQQLLSKDEQ-----LLHLSSQLEDSYNQV 2831
Query: 425 SSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQE 484
S K + + + + ++EK E AA + +T+ Q
Sbjct: 2832 QSFS-----------KAMASLQNERDHLWNELEKFRKSEEGKQRSAA--QPSTSPAEVQS 2878
Query: 485 LKQLKEEFERYKMRAQVVLKSKNTKDGNLGK---ELEAAQEQLAELKEKYISLRLSCEEL 541
LK+ + + R LK+ + + + EL + QL E ++K + ++ EEL
Sbjct: 2879 LKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEEL 2938
Query: 542 EHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDL 601
+QE W+ E LH+ +E+ + +R +K ++ L +++KD
Sbjct: 2939 ----RQENLSWQHE------LHQLRMEKSSWEIHERRMK---------EQYLMAISDKDQ 2979
Query: 602 ELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQL-----------AAANE 650
+L L+++ + SS S TQ L++ A+ +
Sbjct: 2980 QLSHLQNLI--------------------RELRSSSSQTQPLKVQYQRQASPETSASPDG 3019
Query: 651 PTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQLQ---DRLLEE 691
+Y +L R ++ K+ H+ E+ + QL +LLEE
Sbjct: 3020 SQNLVYETELLR--TQLNDSLKEIHQKELRIQQLNSNFSQLLEE 3061
Score = 66.2 bits (160), Expect = 1e-10
Identities = 104/524 (19%), Positives = 221/524 (42%), Gaps = 60/524 (11%)
Query: 194 KQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLR----- 248
+ D+E + E+ + RL EQ+ + + I +Q D +Q D AL
Sbjct: 37 ESDMEFNNTTQEDVQERL-----AYAEQLV-VELKDIIRQKDVQLQQKDEALQEERKAAD 90
Query: 249 -ELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQ 307
+++KL + + L +EE + A G E +L + EE+ E++
Sbjct: 91 NKIKKLKLHAKAKLTSLNKYIEEMK-AQGGTVLPTEPQSEEQLSKHDKSSTEEEM--EIE 147
Query: 308 AIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALE 367
I+ + + + + LQ + + ++ AQ EM + + ++QQ Q +E+ ++ L+
Sbjct: 148 KIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVM----MKQQLQEKEEFISTLQ 203
Query: 368 NQISEVSELLGTYEKAKQKD-------QLAIQKLKERILQLDLENKTLALAASSRSPLDS 420
Q+S+ + ++KD +L +L + + Q D+E + + L+
Sbjct: 204 AQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEE 263
Query: 421 HGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALY 480
H E V ++ L++ L A +++Q+ + + E + E+
Sbjct: 264 HEESLVGRAQV----VDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETER----- 314
Query: 481 YQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEE 540
+E K L E+ E ++ + + +L ++ E A + AEL+ +Y
Sbjct: 315 --EESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRY-------SA 365
Query: 541 LEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKD 600
LE +H+ E ++ + LQ+ QEL+ +D+ KL ++ ++Q ++ + + +
Sbjct: 366 LEQKHKAEMEEKTSHILSLQKT-GQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLE 424
Query: 601 LELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQL 660
+L+Q +S ++ L R P+ +T+S S NE T + E +
Sbjct: 425 DQLQQ-KSKEISQFL--NRLPL------QQHETASQTSFPDVY-----NEGTQAVTEENI 470
Query: 661 ARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQS 704
A + + L +K L + +L++ L E E+ ++ L++
Sbjct: 471 ASLQKRVVELENEKGALLLSSIELEE-LKAENEKLSSQITLLEA 513
Score = 57.8 bits (138), Expect = 4e-08
Identities = 128/621 (20%), Positives = 252/621 (40%), Gaps = 98/621 (15%)
Query: 160 QLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQ 219
Q + +L + S+L + + + S++ +K Q+L+ A + +++ ++L L+
Sbjct: 354 QAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKL---LQDKN 410
Query: 220 EQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRA 279
EQ ++ A+ I Q D+ Q++S L Q E + E +A+
Sbjct: 411 EQAVQS-AQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEEN 469
Query: 280 YAAEQMEGFELQTKQ-----LTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHF 334
A+ Q EL+ ++ + E+EELK+E +EK L E Q
Sbjct: 470 IASLQKRVVELENEKGALLLSSIELEELKAE-----NEKLSSQITLLEAQNRTG------ 518
Query: 335 QAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLGTY--EKAKQKDQLAIQ 392
+ +E+ + ++ + ++ S EE LEN S+ + L E + ++++A
Sbjct: 519 --EADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFL 576
Query: 393 KLK---ERILQLDLENKTLALAASSRSPLDSHG----------EESSLDVNVLKDKMEKL 439
KL+ +R + D E L ++ G E++ D ++ ++ L
Sbjct: 577 KLQLQGKRAEEADHE----VLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSL 632
Query: 440 KRLL--QVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALY------YQQELKQLKEE 491
+ Q + T + L D + S DG+K+ + +Q EL++LK +
Sbjct: 633 PAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQ 692
Query: 492 FERYKMRAQVVLKSKNTKDGNL---GKELEAAQEQLAELKEKYISLRLSCEELEHQHQQE 548
++ K++ + NL KE+ + + E K+ + + L + Q
Sbjct: 693 ILELELNFH---KAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQL 749
Query: 549 ADDWKQELARLQQLHRQ---------ELERCQ-LDFRDRTLK---LEEELH------KQR 589
K EL+ + +L Q E ER + LD+ +T L E++H K +
Sbjct: 750 LSQVK-ELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSK 808
Query: 590 DRALAVLTEK--DLEL---EQLRSV-ALASGLPGRRSPVGGGGPGDPADTSSSDSLTQAL 643
D + VL + D++L EQ + +L S L + S V G +S + L+QAL
Sbjct: 809 DVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQAL 868
Query: 644 QLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQ 703
++KE+EIT + + + +V LQ + E+ ++ E ++
Sbjct: 869 -----------------SQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMT 911
Query: 704 SHIEKNIRDQSREGANLEYLK 724
+ + ++ G ++ LK
Sbjct: 912 EKMVQLNEEKFSLGVEIKTLK 932
Score = 57.4 bits (137), Expect = 5e-08
Identities = 122/601 (20%), Positives = 257/601 (42%), Gaps = 74/601 (12%)
Query: 156 KRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGEL 215
+R+ + +++ L+ +L+ E ++M+ L +KK+ + L+ + +++ + +
Sbjct: 852 ERVRHISSKVEELSQALSQKELEITKMD-QLLLEKKRDVETLQQTIEEKDQQVTEISFSM 910
Query: 216 KGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREAL 275
Q+ E K L + ++ + +L ++ +E+ + ++ L++ + +
Sbjct: 911 TEKMVQLNEEKFSLGVEIKTLKEQLN----LLSRAEEAKKEQVEEDNEVSSGLKQNYDEM 966
Query: 276 --AGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSH 333
AG+ E F+L L +E E+ K +LQA + + R+ L+EE A LK
Sbjct: 967 SPAGQISKEELQHEFDL----LKKENEQRKRKLQAALINRKELLQRVSRLEEELANLK-- 1020
Query: 334 FQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQK 393
+ ++ L+E ++ +VEE + EN+ E SE T K ++ + Q
Sbjct: 1021 -----DESKKEIPLSE---TERGEVEEDK----ENK--EYSEKCVT-SKCQEIEIYLKQT 1065
Query: 394 LKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKSQVT 453
+ E+ ++L K L ++ + ++ + L+DK ++ LLQ ++Q
Sbjct: 1066 ISEKEVELQHIRKDLEEKLAAEEQFQALVKQMN---QTLQDKTNQID-LLQAEISENQAI 1121
Query: 454 LDVEKLCDLEIMPSSEAADGEKATAL---------------YYQQELKQ----LKEEFER 494
++KL I +++A+DG+ + +++ EL++ L++E E+
Sbjct: 1122 --IQKL----ITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQ 1175
Query: 495 YKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQ 554
+ + Q L S+ ++ +E+L + K+ Y L+ +E +++ D +Q
Sbjct: 1176 LQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQ 1235
Query: 555 ELARLQQLHRQELERC-QLDFRDRTLKLEEELHKQRDR-ALAVLTEKDLELEQLRSVALA 612
++++ +L Q + T LEE L K ++ + E +L + A
Sbjct: 1236 LQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDA 1295
Query: 613 SGLPGRRSPVGGGG-----PGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEI 667
S L G S + + S T + +L +E F L EQ+ ++ +EI
Sbjct: 1296 SALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTS-ELTKKSEEVFQL-QEQINKQGLEI 1353
Query: 668 TSLRKQKHRLEVEVHQLQDRLLEE-----GERHREEVAALQSHIEKNIRDQSREGANLEY 722
SL+ H EV LQ +L G H E+ ++K I S++ ++ Y
Sbjct: 1354 ESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLI---SKKEEDVSY 1410
Query: 723 L 723
L
Sbjct: 1411 L 1411
Score = 48.9 bits (115), Expect = 2e-05
Identities = 68/333 (20%), Positives = 128/333 (38%), Gaps = 51/333 (15%)
Query: 415 RSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGE 474
R+PLD + S D+ E ++ L A + D+ + D+++ EA E
Sbjct: 27 RAPLDPELHQES-DMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEE 85
Query: 475 KATA--------LYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGK----------E 516
+ A L+ + +L L + E K + VL ++ + L K E
Sbjct: 86 RKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEME 145
Query: 517 LEAAQEQLAELKEKYISLRLSCEELE-HQHQQEADDWKQELARLQQLHRQE--------- 566
+E + +L E +E +L+ + + Q Q + + ++ + QQL +E
Sbjct: 146 IEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQ 205
Query: 567 LERCQLD------FRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALAS------- 613
L + Q + R++ + E ++ D L ++T+ D+E E + + +
Sbjct: 206 LSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHE 265
Query: 614 -GLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQ--------LARKE 664
L GR V A + L+Q LQ A T E L + E
Sbjct: 266 ESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKME 325
Query: 665 VEITSLRKQKHRLEVEVHQLQDRLLEEGERHRE 697
+E+ + H L+ E+H L ++ + G+ E
Sbjct: 326 LEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAE 358
Score = 32.0 bits (71), Expect = 2.2
Identities = 31/140 (22%), Positives = 58/140 (41%), Gaps = 20/140 (14%)
Query: 156 KRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQ------DLEDASNKAEEERA 209
K +HQ + ++ L S+ + + +EK+ + + +++ DL + E++
Sbjct: 3039 KEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQ 3098
Query: 210 RLEG-------------ELKGLQEQIAETKARLITQQHDRAQEQSDHALM-LRELQKLLQ 255
L+ E G+ + + R Q AQ+Q + + EL+KLL+
Sbjct: 3099 ELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLE 3158
Query: 256 EERTQRQDLELRLEETREAL 275
EER QR E L E +
Sbjct: 3159 EERDQRVAAENALSVAEEQI 3178
Score = 31.2 bits (69), Expect = 3.8
Identities = 38/172 (22%), Positives = 75/172 (43%), Gaps = 9/172 (5%)
Query: 217 GLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALA 276
G Q + ET+ L TQ +D +E L +++L + ++ L ++L +T ++L
Sbjct: 3019 GSQNLVYETEL-LRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLR 3077
Query: 277 GRAYAAEQMEGFELQ-TKQLTREVEELKSELQAIRDEKNQPDPRL---QELQEEAARLKS 332
+Q G L L ++V+EL++ I P + ++ E R
Sbjct: 3078 EN----QQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQ 3133
Query: 333 HFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLGTYEKAK 384
++ QQ++ T ++LR+ + E + A EN +S E + E ++
Sbjct: 3134 QSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEHSE 3185
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 89.0 bits (219), Expect = 2e-17
Identities = 132/638 (20%), Positives = 261/638 (40%), Gaps = 68/638 (10%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLE 212
++ + L L+ +L S + +S+ E KK ++++ +E R R
Sbjct: 1168 DLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1227
Query: 213 GELKGLQEQIAETKARLITQQHDRAQ---EQSDHALMLRELQKLLQEERTQRQDLELRLE 269
L L EQ+ + + + R E S+ L LQ QE +R+ LEL+L+
Sbjct: 1228 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQ 1287
Query: 270 ETR----EALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRL---QE 322
E + + RA AAE+++ + + + ++ + E +S+ + E + + +L QE
Sbjct: 1288 EVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQE 1347
Query: 323 LQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSEL------ 376
L +E R K ++++ + A +QL +++ E+ L+ +++SE
Sbjct: 1348 LLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEE 1407
Query: 377 -LGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDK 435
G E ++ + A ++ + +L + +T+ R L +++++D+ ++
Sbjct: 1408 EAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDL----EQ 1463
Query: 436 MEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGE----KATALYYQQELKQ---L 488
+L L+ RK L EK L + E A+ E +A AL + L++
Sbjct: 1464 QRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEA 1523
Query: 489 KEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQE 548
+EE ER + L++ + ++GK + + ++ LR ELE +
Sbjct: 1524 REELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDE-LTA 1582
Query: 549 ADDWKQELA----RLQQLHRQELE---------RCQL--DFRDRTLKLEEELHKQRDRAL 593
A+D K L L+ H ++L+ R QL RD ++ +EE KQR A+
Sbjct: 1583 AEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRTLAV 1641
Query: 594 AVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTF 653
A + + ELE+L++ ++G + + L+ A
Sbjct: 1642 AARKKLEGELEELKAQMASAG-------------------QGKEEAVKQLRKMQAQMKEL 1682
Query: 654 FLYAEQLARKEVEITSLRKQKHR----LEVEVHQLQDRLLEEGERHREEVAALQSHIEKN 709
+ E+ EI S ++ + LE EV +LQ+ L R+ ++
Sbjct: 1683 WREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEV 1742
Query: 710 IRDQSREGANLEYLKNIIYRFLTLPDSLGRQQTLTAIL 747
+ A LE + + R L + L +Q+ + +L
Sbjct: 1743 ANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELL 1780
Score = 85.5 bits (210), Expect = 2e-16
Identities = 108/461 (23%), Positives = 199/461 (43%), Gaps = 53/461 (11%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLA------DKKKMKQDLEDASNKAEE 206
E++++ L+ +L L SS V + +E + D + +LED AE+
Sbjct: 1526 ELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAED 1585
Query: 207 ERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHAL--MLRELQKLLQEERTQR--- 261
+ RLE ++ L+ Q Q D A E+ L LR+ + EER QR
Sbjct: 1586 AKLRLEVTVQALKTQHERD-----LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLA 1640
Query: 262 ----QDLELRLEETREALA----GRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEK 313
+ LE LEE + +A G+ A +Q+ + Q K+L REVEE ++ + I +
Sbjct: 1641 VAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQN 1700
Query: 314 NQPDPRLQELQEEAARLKSHF--------QAQLQQEMRKTALAEDQLRQQSQVEEQRVAA 365
+ + RL+ L+ E RL+ QAQ ++ +A L + + +EE+R
Sbjct: 1701 RESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKR--Q 1758
Query: 366 LENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEES 425
LE ++ ++ E L E+ + +L + ++ +LQ++ L+ S + +S ++
Sbjct: 1759 LEGRLGQLEEEL---EEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQL 1815
Query: 426 SLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQEL 485
+ L+ ++ + + A K + KL E E + + L + E
Sbjct: 1816 ERQIQELRGRLGEEDAGAR-ARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAE- 1873
Query: 486 KQLK------EEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCE 539
K+LK EE R + + L+ N + L ++LE A+E+ + + L+ E
Sbjct: 1874 KRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELE 1933
Query: 540 ELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLK 580
++ + A+ +E+ L R L R L F RT++
Sbjct: 1934 DV----TESAESMNREVTTL----RNRLRRGPLTFTTRTVR 1966
Score = 84.7 bits (208), Expect = 3e-16
Identities = 171/644 (26%), Positives = 264/644 (40%), Gaps = 110/644 (17%)
Query: 154 VDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEG 213
++ RL + +Q A + ++ + + + EA+ +AD + + E + E+ + RL+G
Sbjct: 1029 LEDRLAEFSSQAAEEEEKVKSLNKLRLKYEAT-IADMEDRLRKEEKGRQELEKLKRRLDG 1087
Query: 214 ELKGLQEQIAETKARL--ITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEET 271
E LQEQ+ E + R + Q R +E+ AL E +E R L L+
Sbjct: 1088 ESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE------DEGGARAQL---LKSL 1138
Query: 272 REALAGRAYAAEQMEG-------FELQTKQLTREVEELKSEL----------QAIRDEKN 314
REA A A A E +E E Q + L E+E L+ EL Q +R ++
Sbjct: 1139 REAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKRE 1198
Query: 315 QPDPRLQELQEEAARL---------KSHFQA------QLQQEMR------KTALAED--- 350
Q L++ EE R+ + H QA QL+Q R KT LA +
Sbjct: 1199 QEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEV 1258
Query: 351 --------QLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLD 402
L+ Q EQR LE Q+ EV G E+A+ + A +KL+ Q +
Sbjct: 1259 SELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAE---AAEKLQRA--QAE 1313
Query: 403 LENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVA-ARKSQVTLDVEKLCD 461
LEN + AL + + E SS + L D E L+ + A S+V +
Sbjct: 1314 LENVSGALNEAESKTIRLSKELSSTEAQ-LHDAQELLQEETRAKLALGSRVRAMEAEAAG 1372
Query: 462 LEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQV---VLKSKNTKDGNLGKELE 518
L EAA E+A +EL+ + + ++ R + L++ +E E
Sbjct: 1373 LREQLEEEAAARERAG-----RELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAE 1427
Query: 519 AAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRT 578
A ++LAE E L L QQE DD +L + +QL LE+ Q F D+
Sbjct: 1428 ALTQRLAEKTETVDRLERGRRRL----QQELDDATMDLEQQRQLV-STLEKKQRKF-DQL 1481
Query: 579 LKLEE----ELHKQRDRALAVLTEKD---------LELEQLRSVALASGLPGRRSPVGGG 625
L E+ ++R+RA A E++ LE EQ L R+ +
Sbjct: 1482 LAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEAL 1541
Query: 626 GPGDPADTSSSDSLTQALQLA--AANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQ 683
S L +A ++A AAN+ Q+ E E+T+ K RLEV V
Sbjct: 1542 LSSKDDVGKSVHELERACRVAEQAAND-----LRAQVTELEDELTAAEDAKLRLEVTVQA 1596
Query: 684 LQ---DRLL----EEGERHREEVAALQSHIEKNIRDQSREGANL 720
L+ +R L E GE R ++A E RD+ R+ L
Sbjct: 1597 LKTQHERDLQGRDEAGEERRRQLAKQLRDAEVE-RDEERKQRTL 1639
Score = 83.2 bits (204), Expect = 8e-16
Identities = 129/587 (21%), Positives = 242/587 (41%), Gaps = 84/587 (14%)
Query: 164 QLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQEQIA 223
+L T L VT++ ++A A + + Q+L+ S AR GEL+G Q+
Sbjct: 861 RLFTKVKPLLQVTRQDEVLQAR--AQELQKVQELQQQS-------AREVGELQGRVAQLE 911
Query: 224 ETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAE 283
E +ARL Q A+ + E ++ ++Q+LEL + E + +
Sbjct: 912 EERARLAEQLRAEAE-------LCAEAEETRGRLAARKQELELVVSELEARVGEEEECSR 964
Query: 284 QMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMR 343
QM + + K+L + ++EL++ L+A + Q+LQ E K +A++++
Sbjct: 965 QM---QTEKKRLQQHIQELEAHLEAEEGAR-------QKLQLE----KVTTEAKMKKFEE 1010
Query: 344 KTALAEDQ---LRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQ 400
L EDQ L ++ ++ E R+A +Q +E E + + K + K + I +++R+ +
Sbjct: 1011 DLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRK 1070
Query: 401 LDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLC 460
E K + LD GE S L +++ + + Q+ ++ ++ + +
Sbjct: 1071 ---EEKGRQELEKLKRRLD--GESSELQEQMVEQQQRAEELRAQLGRKEEELQAALAR-- 1123
Query: 461 DLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAA 520
+E G +A L +E + E + +V + +LG+ELEA
Sbjct: 1124 -------AEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEAL 1176
Query: 521 QEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLK 580
+ +L E + + +EL + +QE + K+ L ++H ++ + +
Sbjct: 1177 RGEL----EDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE 1232
Query: 581 LEEEL----------HKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPV------GG 624
L E+L K R A ++E EL L++ RR + G
Sbjct: 1233 LAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGR 1292
Query: 625 GGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQL 684
G G+ A +++ L +A Q N + L E + L K+ E ++H
Sbjct: 1293 AGDGERARAEAAEKLQRA-QAELEN------VSGALNEAESKTIRLSKELSSTEAQLHDA 1345
Query: 685 QDRLLEE-------GERHR---EEVAALQSHIEKNIRDQSREGANLE 721
Q+ L EE G R R E A L+ +E+ + R G L+
Sbjct: 1346 QELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQ 1392
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 89.0 bits (219), Expect = 2e-17
Identities = 132/638 (20%), Positives = 261/638 (40%), Gaps = 68/638 (10%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLE 212
++ + L L+ +L S + +S+ E KK ++++ +E R R
Sbjct: 1160 DLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1219
Query: 213 GELKGLQEQIAETKARLITQQHDRAQ---EQSDHALMLRELQKLLQEERTQRQDLELRLE 269
L L EQ+ + + + R E S+ L LQ QE +R+ LEL+L+
Sbjct: 1220 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQ 1279
Query: 270 ETR----EALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRL---QE 322
E + + RA AAE+++ + + + ++ + E +S+ + E + + +L QE
Sbjct: 1280 EVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQE 1339
Query: 323 LQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSEL------ 376
L +E R K ++++ + A +QL +++ E+ L+ +++SE
Sbjct: 1340 LLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEE 1399
Query: 377 -LGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDK 435
G E ++ + A ++ + +L + +T+ R L +++++D+ ++
Sbjct: 1400 EAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDL----EQ 1455
Query: 436 MEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGE----KATALYYQQELKQ---L 488
+L L+ RK L EK L + E A+ E +A AL + L++
Sbjct: 1456 QRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEA 1515
Query: 489 KEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQE 548
+EE ER + L++ + ++GK + + ++ LR ELE +
Sbjct: 1516 REELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDE-LTA 1574
Query: 549 ADDWKQELA----RLQQLHRQELE---------RCQL--DFRDRTLKLEEELHKQRDRAL 593
A+D K L L+ H ++L+ R QL RD ++ +EE KQR A+
Sbjct: 1575 AEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRTLAV 1633
Query: 594 AVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTF 653
A + + ELE+L++ ++G + + L+ A
Sbjct: 1634 AARKKLEGELEELKAQMASAG-------------------QGKEEAVKQLRKMQAQMKEL 1674
Query: 654 FLYAEQLARKEVEITSLRKQKHR----LEVEVHQLQDRLLEEGERHREEVAALQSHIEKN 709
+ E+ EI S ++ + LE EV +LQ+ L R+ ++
Sbjct: 1675 WREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEV 1734
Query: 710 IRDQSREGANLEYLKNIIYRFLTLPDSLGRQQTLTAIL 747
+ A LE + + R L + L +Q+ + +L
Sbjct: 1735 ANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELL 1772
Score = 85.5 bits (210), Expect = 2e-16
Identities = 108/461 (23%), Positives = 199/461 (43%), Gaps = 53/461 (11%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLA------DKKKMKQDLEDASNKAEE 206
E++++ L+ +L L SS V + +E + D + +LED AE+
Sbjct: 1518 ELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAED 1577
Query: 207 ERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHAL--MLRELQKLLQEERTQR--- 261
+ RLE ++ L+ Q Q D A E+ L LR+ + EER QR
Sbjct: 1578 AKLRLEVTVQALKTQHERD-----LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLA 1632
Query: 262 ----QDLELRLEETREALA----GRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEK 313
+ LE LEE + +A G+ A +Q+ + Q K+L REVEE ++ + I +
Sbjct: 1633 VAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQN 1692
Query: 314 NQPDPRLQELQEEAARLKSHF--------QAQLQQEMRKTALAEDQLRQQSQVEEQRVAA 365
+ + RL+ L+ E RL+ QAQ ++ +A L + + +EE+R
Sbjct: 1693 RESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKR--Q 1750
Query: 366 LENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEES 425
LE ++ ++ E L E+ + +L + ++ +LQ++ L+ S + +S ++
Sbjct: 1751 LEGRLGQLEEEL---EEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQL 1807
Query: 426 SLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQEL 485
+ L+ ++ + + A K + KL E E + + L + E
Sbjct: 1808 ERQIQELRGRLGEEDAGAR-ARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAE- 1865
Query: 486 KQLK------EEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCE 539
K+LK EE R + + L+ N + L ++LE A+E+ + + L+ E
Sbjct: 1866 KRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELE 1925
Query: 540 ELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLK 580
++ + A+ +E+ L R L R L F RT++
Sbjct: 1926 DV----TESAESMNREVTTL----RNRLRRGPLTFTTRTVR 1958
Score = 84.7 bits (208), Expect = 3e-16
Identities = 171/644 (26%), Positives = 264/644 (40%), Gaps = 110/644 (17%)
Query: 154 VDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEG 213
++ RL + +Q A + ++ + + + EA+ +AD + + E + E+ + RL+G
Sbjct: 1021 LEDRLAEFSSQAAEEEEKVKSLNKLRLKYEAT-IADMEDRLRKEEKGRQELEKLKRRLDG 1079
Query: 214 ELKGLQEQIAETKARL--ITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEET 271
E LQEQ+ E + R + Q R +E+ AL E +E R L L+
Sbjct: 1080 ESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE------DEGGARAQL---LKSL 1130
Query: 272 REALAGRAYAAEQMEG-------FELQTKQLTREVEELKSEL----------QAIRDEKN 314
REA A A A E +E E Q + L E+E L+ EL Q +R ++
Sbjct: 1131 REAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKRE 1190
Query: 315 QPDPRLQELQEEAARL---------KSHFQA------QLQQEMR------KTALAED--- 350
Q L++ EE R+ + H QA QL+Q R KT LA +
Sbjct: 1191 QEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEV 1250
Query: 351 --------QLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLD 402
L+ Q EQR LE Q+ EV G E+A+ + A +KL+ Q +
Sbjct: 1251 SELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAE---AAEKLQRA--QAE 1305
Query: 403 LENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVA-ARKSQVTLDVEKLCD 461
LEN + AL + + E SS + L D E L+ + A S+V +
Sbjct: 1306 LENVSGALNEAESKTIRLSKELSSTEAQ-LHDAQELLQEETRAKLALGSRVRAMEAEAAG 1364
Query: 462 LEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQV---VLKSKNTKDGNLGKELE 518
L EAA E+A +EL+ + + ++ R + L++ +E E
Sbjct: 1365 LREQLEEEAAARERAG-----RELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAE 1419
Query: 519 AAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRT 578
A ++LAE E L L QQE DD +L + +QL LE+ Q F D+
Sbjct: 1420 ALTQRLAEKTETVDRLERGRRRL----QQELDDATMDLEQQRQLV-STLEKKQRKF-DQL 1473
Query: 579 LKLEE----ELHKQRDRALAVLTEKD---------LELEQLRSVALASGLPGRRSPVGGG 625
L E+ ++R+RA A E++ LE EQ L R+ +
Sbjct: 1474 LAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEAL 1533
Query: 626 GPGDPADTSSSDSLTQALQLA--AANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQ 683
S L +A ++A AAN+ Q+ E E+T+ K RLEV V
Sbjct: 1534 LSSKDDVGKSVHELERACRVAEQAAND-----LRAQVTELEDELTAAEDAKLRLEVTVQA 1588
Query: 684 LQ---DRLL----EEGERHREEVAALQSHIEKNIRDQSREGANL 720
L+ +R L E GE R ++A E RD+ R+ L
Sbjct: 1589 LKTQHERDLQGRDEAGEERRRQLAKQLRDAEVE-RDEERKQRTL 1631
Score = 83.2 bits (204), Expect = 8e-16
Identities = 129/587 (21%), Positives = 242/587 (41%), Gaps = 84/587 (14%)
Query: 164 QLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQEQIA 223
+L T L VT++ ++A A + + Q+L+ S AR GEL+G Q+
Sbjct: 853 RLFTKVKPLLQVTRQDEVLQAR--AQELQKVQELQQQS-------AREVGELQGRVAQLE 903
Query: 224 ETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAE 283
E +ARL Q A+ + E ++ ++Q+LEL + E + +
Sbjct: 904 EERARLAEQLRAEAE-------LCAEAEETRGRLAARKQELELVVSELEARVGEEEECSR 956
Query: 284 QMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMR 343
QM + + K+L + ++EL++ L+A + Q+LQ E K +A++++
Sbjct: 957 QM---QTEKKRLQQHIQELEAHLEAEEGAR-------QKLQLE----KVTTEAKMKKFEE 1002
Query: 344 KTALAEDQ---LRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQ 400
L EDQ L ++ ++ E R+A +Q +E E + + K + K + I +++R+ +
Sbjct: 1003 DLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRK 1062
Query: 401 LDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLC 460
E K + LD GE S L +++ + + Q+ ++ ++ + +
Sbjct: 1063 ---EEKGRQELEKLKRRLD--GESSELQEQMVEQQQRAEELRAQLGRKEEELQAALAR-- 1115
Query: 461 DLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAA 520
+E G +A L +E + E + +V + +LG+ELEA
Sbjct: 1116 -------AEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEAL 1168
Query: 521 QEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLK 580
+ +L E + + +EL + +QE + K+ L ++H ++ + +
Sbjct: 1169 RGEL----EDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE 1224
Query: 581 LEEEL----------HKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPV------GG 624
L E+L K R A ++E EL L++ RR + G
Sbjct: 1225 LAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGR 1284
Query: 625 GGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQL 684
G G+ A +++ L +A Q N + L E + L K+ E ++H
Sbjct: 1285 AGDGERARAEAAEKLQRA-QAELEN------VSGALNEAESKTIRLSKELSSTEAQLHDA 1337
Query: 685 QDRLLEE-------GERHR---EEVAALQSHIEKNIRDQSREGANLE 721
Q+ L EE G R R E A L+ +E+ + R G L+
Sbjct: 1338 QELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQ 1384
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 89.0 bits (219), Expect = 2e-17
Identities = 132/638 (20%), Positives = 261/638 (40%), Gaps = 68/638 (10%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLE 212
++ + L L+ +L S + +S+ E KK ++++ +E R R
Sbjct: 1201 DLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1260
Query: 213 GELKGLQEQIAETKARLITQQHDRAQ---EQSDHALMLRELQKLLQEERTQRQDLELRLE 269
L L EQ+ + + + R E S+ L LQ QE +R+ LEL+L+
Sbjct: 1261 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQ 1320
Query: 270 ETR----EALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRL---QE 322
E + + RA AAE+++ + + + ++ + E +S+ + E + + +L QE
Sbjct: 1321 EVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQE 1380
Query: 323 LQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSEL------ 376
L +E R K ++++ + A +QL +++ E+ L+ +++SE
Sbjct: 1381 LLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEE 1440
Query: 377 -LGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDK 435
G E ++ + A ++ + +L + +T+ R L +++++D+ ++
Sbjct: 1441 EAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDL----EQ 1496
Query: 436 MEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGE----KATALYYQQELKQ---L 488
+L L+ RK L EK L + E A+ E +A AL + L++
Sbjct: 1497 QRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEA 1556
Query: 489 KEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQE 548
+EE ER + L++ + ++GK + + ++ LR ELE +
Sbjct: 1557 REELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDE-LTA 1615
Query: 549 ADDWKQELA----RLQQLHRQELE---------RCQL--DFRDRTLKLEEELHKQRDRAL 593
A+D K L L+ H ++L+ R QL RD ++ +EE KQR A+
Sbjct: 1616 AEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRTLAV 1674
Query: 594 AVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTF 653
A + + ELE+L++ ++G + + L+ A
Sbjct: 1675 AARKKLEGELEELKAQMASAG-------------------QGKEEAVKQLRKMQAQMKEL 1715
Query: 654 FLYAEQLARKEVEITSLRKQKHR----LEVEVHQLQDRLLEEGERHREEVAALQSHIEKN 709
+ E+ EI S ++ + LE EV +LQ+ L R+ ++
Sbjct: 1716 WREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEV 1775
Query: 710 IRDQSREGANLEYLKNIIYRFLTLPDSLGRQQTLTAIL 747
+ A LE + + R L + L +Q+ + +L
Sbjct: 1776 ANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELL 1813
Score = 85.5 bits (210), Expect = 2e-16
Identities = 108/461 (23%), Positives = 199/461 (43%), Gaps = 53/461 (11%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLA------DKKKMKQDLEDASNKAEE 206
E++++ L+ +L L SS V + +E + D + +LED AE+
Sbjct: 1559 ELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAED 1618
Query: 207 ERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHAL--MLRELQKLLQEERTQR--- 261
+ RLE ++ L+ Q Q D A E+ L LR+ + EER QR
Sbjct: 1619 AKLRLEVTVQALKTQHERD-----LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLA 1673
Query: 262 ----QDLELRLEETREALA----GRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEK 313
+ LE LEE + +A G+ A +Q+ + Q K+L REVEE ++ + I +
Sbjct: 1674 VAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQN 1733
Query: 314 NQPDPRLQELQEEAARLKSHF--------QAQLQQEMRKTALAEDQLRQQSQVEEQRVAA 365
+ + RL+ L+ E RL+ QAQ ++ +A L + + +EE+R
Sbjct: 1734 RESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKR--Q 1791
Query: 366 LENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEES 425
LE ++ ++ E L E+ + +L + ++ +LQ++ L+ S + +S ++
Sbjct: 1792 LEGRLGQLEEEL---EEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQL 1848
Query: 426 SLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQEL 485
+ L+ ++ + + A K + KL E E + + L + E
Sbjct: 1849 ERQIQELRGRLGEEDAGAR-ARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAE- 1906
Query: 486 KQLK------EEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCE 539
K+LK EE R + + L+ N + L ++LE A+E+ + + L+ E
Sbjct: 1907 KRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELE 1966
Query: 540 ELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLK 580
++ + A+ +E+ L R L R L F RT++
Sbjct: 1967 DV----TESAESMNREVTTL----RNRLRRGPLTFTTRTVR 1999
Score = 84.7 bits (208), Expect = 3e-16
Identities = 171/644 (26%), Positives = 264/644 (40%), Gaps = 110/644 (17%)
Query: 154 VDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEG 213
++ RL + +Q A + ++ + + + EA+ +AD + + E + E+ + RL+G
Sbjct: 1062 LEDRLAEFSSQAAEEEEKVKSLNKLRLKYEAT-IADMEDRLRKEEKGRQELEKLKRRLDG 1120
Query: 214 ELKGLQEQIAETKARL--ITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEET 271
E LQEQ+ E + R + Q R +E+ AL E +E R L L+
Sbjct: 1121 ESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE------DEGGARAQL---LKSL 1171
Query: 272 REALAGRAYAAEQMEG-------FELQTKQLTREVEELKSEL----------QAIRDEKN 314
REA A A A E +E E Q + L E+E L+ EL Q +R ++
Sbjct: 1172 REAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKRE 1231
Query: 315 QPDPRLQELQEEAARL---------KSHFQA------QLQQEMR------KTALAED--- 350
Q L++ EE R+ + H QA QL+Q R KT LA +
Sbjct: 1232 QEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEV 1291
Query: 351 --------QLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLD 402
L+ Q EQR LE Q+ EV G E+A+ + A +KL+ Q +
Sbjct: 1292 SELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAE---AAEKLQRA--QAE 1346
Query: 403 LENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVA-ARKSQVTLDVEKLCD 461
LEN + AL + + E SS + L D E L+ + A S+V +
Sbjct: 1347 LENVSGALNEAESKTIRLSKELSSTEAQ-LHDAQELLQEETRAKLALGSRVRAMEAEAAG 1405
Query: 462 LEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQV---VLKSKNTKDGNLGKELE 518
L EAA E+A +EL+ + + ++ R + L++ +E E
Sbjct: 1406 LREQLEEEAAARERAG-----RELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAE 1460
Query: 519 AAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRT 578
A ++LAE E L L QQE DD +L + +QL LE+ Q F D+
Sbjct: 1461 ALTQRLAEKTETVDRLERGRRRL----QQELDDATMDLEQQRQLV-STLEKKQRKF-DQL 1514
Query: 579 LKLEE----ELHKQRDRALAVLTEKD---------LELEQLRSVALASGLPGRRSPVGGG 625
L E+ ++R+RA A E++ LE EQ L R+ +
Sbjct: 1515 LAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEAL 1574
Query: 626 GPGDPADTSSSDSLTQALQLA--AANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQ 683
S L +A ++A AAN+ Q+ E E+T+ K RLEV V
Sbjct: 1575 LSSKDDVGKSVHELERACRVAEQAAND-----LRAQVTELEDELTAAEDAKLRLEVTVQA 1629
Query: 684 LQ---DRLL----EEGERHREEVAALQSHIEKNIRDQSREGANL 720
L+ +R L E GE R ++A E RD+ R+ L
Sbjct: 1630 LKTQHERDLQGRDEAGEERRRQLAKQLRDAEVE-RDEERKQRTL 1672
Score = 83.2 bits (204), Expect = 8e-16
Identities = 129/587 (21%), Positives = 242/587 (41%), Gaps = 84/587 (14%)
Query: 164 QLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQEQIA 223
+L T L VT++ ++A A + + Q+L+ S AR GEL+G Q+
Sbjct: 894 RLFTKVKPLLQVTRQDEVLQAR--AQELQKVQELQQQS-------AREVGELQGRVAQLE 944
Query: 224 ETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAE 283
E +ARL Q A+ + E ++ ++Q+LEL + E + +
Sbjct: 945 EERARLAEQLRAEAE-------LCAEAEETRGRLAARKQELELVVSELEARVGEEEECSR 997
Query: 284 QMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMR 343
QM + + K+L + ++EL++ L+A + Q+LQ E K +A++++
Sbjct: 998 QM---QTEKKRLQQHIQELEAHLEAEEGAR-------QKLQLE----KVTTEAKMKKFEE 1043
Query: 344 KTALAEDQ---LRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQ 400
L EDQ L ++ ++ E R+A +Q +E E + + K + K + I +++R+ +
Sbjct: 1044 DLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRK 1103
Query: 401 LDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLC 460
E K + LD GE S L +++ + + Q+ ++ ++ + +
Sbjct: 1104 ---EEKGRQELEKLKRRLD--GESSELQEQMVEQQQRAEELRAQLGRKEEELQAALAR-- 1156
Query: 461 DLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAA 520
+E G +A L +E + E + +V + +LG+ELEA
Sbjct: 1157 -------AEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEAL 1209
Query: 521 QEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLK 580
+ +L E + + +EL + +QE + K+ L ++H ++ + +
Sbjct: 1210 RGEL----EDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE 1265
Query: 581 LEEEL----------HKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPV------GG 624
L E+L K R A ++E EL L++ RR + G
Sbjct: 1266 LAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGR 1325
Query: 625 GGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQL 684
G G+ A +++ L +A Q N + L E + L K+ E ++H
Sbjct: 1326 AGDGERARAEAAEKLQRA-QAELEN------VSGALNEAESKTIRLSKELSSTEAQLHDA 1378
Query: 685 QDRLLEE-------GERHR---EEVAALQSHIEKNIRDQSREGANLE 721
Q+ L EE G R R E A L+ +E+ + R G L+
Sbjct: 1379 QELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQ 1425
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 89.0 bits (219), Expect = 2e-17
Identities = 159/757 (21%), Positives = 303/757 (40%), Gaps = 104/757 (13%)
Query: 16 DLLETIETQKKQLLQYQARLKDVVRAYKSLLKEKEALEASIKVLSVSHEADVGLAGVQLP 75
++ E E K++L + +A+ K++ +L++EK L+ L V EAD LA
Sbjct: 855 NMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQ-----LQVQAEAD-SLA----- 903
Query: 76 GLTFPDSVDDRCSTHSEDSTGTATSLDTAASLTSTKGEFGVEDDRPARGPPPPKSEEASW 135
++RC + T L+ + + E D+ K +
Sbjct: 904 ------DAEERC----DQLIKTKIQLEAKIKEVTERAE----DEEEINAELTAKKRKLED 949
Query: 136 SESGVSSSSGDGPFAGGEVDKRLH-------QLKTQLATLTSSLATVTQEKSRMEASYLA 188
S + D +V+K H L ++A L ++A +T+EK ++ ++
Sbjct: 950 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1009
Query: 189 DKKKMKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLR 248
++ + ED N + + +LE ++ L+ + + K I +RA+ + + L L
Sbjct: 1010 TLDDLQAE-EDKVNTLTKAKIKLEQQVDDLEGSLEQEKK--IRMDLERAKRKLEGDLKLA 1066
Query: 249 ELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTK--QLTREVEELKSEL 306
+ + E Q+ D +L+ +E + EQ G +LQ K +L +EEL+ E+
Sbjct: 1067 QESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEI 1126
Query: 307 QAIRDEKNQPDPRLQELQEEAARLKSHFQ-----AQLQQEMRKTALAEDQ-----LRQQS 356
+A R + + + + +L E + + Q EM K AE Q L + +
Sbjct: 1127 EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT 1186
Query: 357 QVEEQRVAALENQ----ISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAA 412
E A L + ++E+ E + ++ KQK + ++K I L +T++ A
Sbjct: 1187 LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAK 1246
Query: 413 SSRSPLDSHGEESSLDVNVLKDKMEKL-KRLLQVAARKSQVTLDVEKLCDLEIMPSSEAA 471
+ + E+ ++ +++ ++L L AR + + + D + S+ +
Sbjct: 1247 GNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLS 1306
Query: 472 DGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKD-------------GNLGKELE 518
G++A ++ +QL+EE + A + S++ D L + +
Sbjct: 1307 RGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMS 1366
Query: 519 AAQEQLAELKEKYISLRLS-CEELEH------QHQQEADDWKQ-------ELARLQQLHR 564
A ++A+ + KY + + EELE Q Q+A++ + L + +Q +
Sbjct: 1367 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQ 1426
Query: 565 QELERCQLDFRDRTLKLEEELHKQR--DRALAVLTEK------DLELEQLRSVALASGLP 616
E+E +D KQR D+ LA +K +LE Q S +L++ L
Sbjct: 1427 NEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELF 1486
Query: 617 GRRSPVGGGGPGDPADTSSSDSLTQALQLAAAN---EPTFFLYAEQLARKEVEITSLRKQ 673
++ + +SL Q L N + EQ+A I L K
Sbjct: 1487 KIKN-------------AYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKI 1533
Query: 674 KHRLEVEVHQLQDRLLE-EGERHREEVAALQSHIEKN 709
K ++E E +LQ L E E EE L+ +E N
Sbjct: 1534 KKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELN 1570
Score = 83.6 bits (205), Expect = 7e-16
Identities = 131/632 (20%), Positives = 274/632 (43%), Gaps = 79/632 (12%)
Query: 153 EVDKRLHQL---KTQLATLTSSLATVTQEKSRMEASYLADKKKMKQ----------DLED 199
+ ++R QL K QL + +++ + A A K+K++ DLE
Sbjct: 904 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 963
Query: 200 ASNKAEEERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERT 259
K E+E+ E ++K L E++A + ++ Q H L +LQ + T
Sbjct: 964 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1023
Query: 260 QRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVE-ELKSELQA---IRDEKNQ 315
+ +++LE+ + L G + EQ + + ++ R++E +LK ++ I ++K Q
Sbjct: 1024 LTK-AKIKLEQQVDDLEG---SLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQ 1079
Query: 316 PDPRLQELQEEAARLKSHFQ------AQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQ 369
D +L++ + E + L+S + QLQ+++++ ++L ++ + E A E Q
Sbjct: 1080 LDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQ 1139
Query: 370 ISEVS----ELLGTYEKAKQKDQLAIQKLKER-----ILQLDLENKTLALAASSRSPLDS 420
S++S E+ E+A I+ K+R ++ DLE TL A++ +
Sbjct: 1140 RSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKK 1199
Query: 421 HGEESSLDVNVLKDKMEKLKRLLQ-VAARKSQVTLDVEKLC-DLEIMPSSEAADGEKATA 478
H + V L ++++ L+R+ Q + KS++ ++++ L ++E + ++ + A
Sbjct: 1200 HAD----SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRA 1255
Query: 479 LYYQ-QELKQLKEEFERY-----KMRAQVVLKS---------KNTKDGNLGKELEAAQEQ 523
L Q E+K +EE +R RA++ +S K+T L + +A +Q
Sbjct: 1256 LEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQ 1315
Query: 524 LAELKEK--------------YISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELER 569
+ ELK + S R C+ L Q+++E + K EL R E+ +
Sbjct: 1316 IEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEE-QEAKAELQRAMSKANSEVAQ 1374
Query: 570 CQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGD 629
+ + ++ EEL + + + L + + +E + A + L + +
Sbjct: 1375 WRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVN--AKCASLEKTKQRLQNEVEDL 1432
Query: 630 PADTSSSDSLTQALQLAAAN-EPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQLQ--- 685
D +++ AL N + + ++ E+ + +K+ L E+ +++
Sbjct: 1433 MIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAY 1492
Query: 686 DRLLEEGERHREEVAALQSHIEKNIRDQSREG 717
+ L++ E + E LQ I ++ +Q EG
Sbjct: 1493 EESLDQLETLKRENKNLQQEI-SDLTEQIAEG 1523
Score = 76.6 bits (187), Expect = 8e-14
Identities = 109/546 (19%), Positives = 235/546 (43%), Gaps = 50/546 (9%)
Query: 188 ADKKKMKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALML 247
A+ +K ++++ K +EE A+ E + K L+E++ L+ +++D + A L
Sbjct: 847 AETEKEMANMKEEFEKTKEELAKTEAKRKELEEKM----VTLMQEKNDLQLQVQAEADSL 902
Query: 248 RELQKLLQEERTQRQDLELRLEETREALAG----RAYAAEQMEGFELQTKQLTREVEELK 303
+ ++ + + LE +++E E A + E + +L +++++L+
Sbjct: 903 ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 962
Query: 304 SELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRV 363
L + EK+ + +++ L EE A L A+L +E + A Q Q EE +V
Sbjct: 963 LTLAKVEKEKHATENKVKNLTEEMAGLDETI-AKLTKEKKALQEAHQQTLDDLQAEEDKV 1021
Query: 364 AALENQ----ISEVSELLGTYEKAKQKDQLAIQKLKERIL-QLDLENKTLALAASSRSPL 418
L +V +L G+ E+ K K ++ +++ K ++ L L ++ + + L
Sbjct: 1022 NTLTKAKIKLEQQVDDLEGSLEQEK-KIRMDLERAKRKLEGDLKLAQESTMDIENDKQQL 1080
Query: 419 DSHGEESSLDVNVLKDKMEKLKRL-LQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKAT 477
D ++ +++ L+ K+E + L +Q+ + ++ +E+L E + E+A+
Sbjct: 1081 DEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEEL--------EEEIEAERAS 1132
Query: 478 ALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAA-QEQLAELKEKYISLRL 536
+++ L E E R + + + K+ EA Q+ +L+E +
Sbjct: 1133 RAKAEKQRSDLSRELEEISERLEEA-GGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA 1191
Query: 537 SCEELEHQHQQEADDWKQELARLQQLHRQELER----CQLDFRDRTLKLE---------E 583
+ L +H + +++ LQ++ +Q+LE+ +++ D +E E
Sbjct: 1192 TAATLRKKHADSVAELGEQIDNLQRV-KQKLEKEKSEMKMEIDDLASNMETVSKAKGNLE 1250
Query: 584 ELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQAL 643
++ + + L+ + K+ E ++ L + L +R+ + D+L L
Sbjct: 1251 KMCRALEDQLSEIKTKEEEQQR-----LINDLTAQRARLQTESGEYSRQLDEKDTLVSQL 1305
Query: 644 QLAAANEPTFFLYAEQLARK-EVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAAL 702
+ + F E+L R+ E EI + H L+ H D L E+ E +E A L
Sbjct: 1306 ---SRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDC-DLLREQYEEEQEAKAEL 1361
Query: 703 QSHIEK 708
Q + K
Sbjct: 1362 QRAMSK 1367
Score = 70.9 bits (172), Expect = 4e-12
Identities = 124/615 (20%), Positives = 255/615 (41%), Gaps = 90/615 (14%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKA---EEERA 209
+++K ++K ++ L S++ TV++ K +E KM + LED ++ EEE+
Sbjct: 1220 KLEKEKSEMKMEIDDLASNMETVSKAKGNLE--------KMCRALEDQLSEIKTKEEEQQ 1271
Query: 210 RLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLE 269
RL +L +ARL T+ + +++ + ++ +L + Q Q ++L+ +LE
Sbjct: 1272 RLINDLTA-------QRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLE 1324
Query: 270 ETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAAR 329
E +A + A+A + ++ E +E K+ELQ + N E A+
Sbjct: 1325 EEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANS----------EVAQ 1374
Query: 330 LKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQL 389
++ ++ Q + A+ +L Q+ Q E+ V A+ + + + EK KQ+ Q
Sbjct: 1375 WRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASL-------EKTKQRLQN 1427
Query: 390 AIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARK 449
++ L +D+E A AA LD + K K E+ L+ + ++
Sbjct: 1428 EVEDL-----MIDVERTNAACAA-----LDKKQRNFDKILAEWKQKCEETHAELEASQKE 1477
Query: 450 SQ-VTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNT 508
S+ ++ ++ K+ + S + + K QQE+ L E+ R + K K
Sbjct: 1478 SRSLSTELFKIKNA-YEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQ 1536
Query: 509 KD---GNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQ 565
+ L LE A+ L + K + ++L +++ + ++ + +E+ ++++ H +
Sbjct: 1537 VEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIR 1596
Query: 566 ELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGG 625
+E Q D ++ + + + + L E +++L +A + R +
Sbjct: 1597 IVESMQSTL-DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILK 1655
Query: 626 GPGDPADTSSSDSLTQALQLAAANEPTFFLYAE---------------QLARKEV----- 665
D + QLA L AE ++A +E+
Sbjct: 1656 DTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASE 1715
Query: 666 -------EITSLRKQKHRLEVEVHQLQ---DRLLEEGERHREEV------AALQSHIEKN 709
+ TSL K +LE ++ Q+Q + +++E E+ AA+ + K
Sbjct: 1716 RVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKK 1775
Query: 710 IRDQSREGANLEYLK 724
+D S A+LE +K
Sbjct: 1776 EQDTS---AHLERMK 1787
Score = 65.9 bits (159), Expect = 1e-10
Identities = 104/539 (19%), Positives = 230/539 (42%), Gaps = 90/539 (16%)
Query: 129 KSEEASWSESGVSSSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLA 188
K ++ + SG+ S D G ++ K++ +L+ ++ L + +++ E
Sbjct: 1083 KLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQ--- 1139
Query: 189 DKKKMKQDLEDASNKAEE--------------ERARLEGELKGLQEQIAETKARLITQQH 234
+ + ++LE+ S + EE A + + L+E + +A T +
Sbjct: 1140 -RSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRK 1198
Query: 235 DRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGF------ 288
A ++ + LQ++ Q+ ++ ++++ +++ + + A +E
Sbjct: 1199 KHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALED 1258
Query: 289 ---ELQTKQLTRE--VEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQA------- 336
E++TK+ ++ + +L ++ ++ E + +L E ++L QA
Sbjct: 1259 QLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEE 1318
Query: 337 ---QLQQEMR-KTALAE---------DQLRQQSQVEEQRVAALENQIS----EVSELLGT 379
QL++E++ K+ALA D LR+Q + E++ A L+ +S EV++
Sbjct: 1319 LKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTK 1378
Query: 380 Y--------EKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDV-- 429
Y E+ ++ + Q+L++ ++ N A ++ L + E+ +DV
Sbjct: 1379 YETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVER 1438
Query: 430 -NVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQL 488
N ++K +R ++ + ++ C+ E EA+ E + EL ++
Sbjct: 1439 TNAACAALDKKQR------NFDKILAEWKQKCE-ETHAELEASQKESRS---LSTELFKI 1488
Query: 489 KEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQE 548
K +E + LK +N NL +E+ EQ+AE ++ L E+++ Q +QE
Sbjct: 1489 KNAYEE-SLDQLETLKRENK---NLQQEISDLTEQIAEGGKRIHEL----EKIKKQVEQE 1540
Query: 549 ADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLR 607
K EL Q +E E + L+++ EL++ + + EKD E++Q++
Sbjct: 1541 ----KSEL----QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMK 1591
Score = 60.8 bits (146), Expect = 5e-09
Identities = 94/438 (21%), Positives = 192/438 (43%), Gaps = 50/438 (11%)
Query: 155 DKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGE 214
DK L + K Q T + +Q++SR ++ L K ++ D + E L+ E
Sbjct: 1454 DKILAEWK-QKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQE 1512
Query: 215 LKGLQEQIAETKARLITQQHDRAQ---EQSDHALMLRELQKLLQEERTQRQDLELRLEET 271
+ L EQIAE R+ + + Q E+S+ L E + L+ E + ++L L +
Sbjct: 1513 ISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQV 1572
Query: 272 REALAGRAYAAEQMEGFELQTKQLTREVEELKSELQA-IRD--------EKNQPDPRLQE 322
+ + + AE+ E + + R VE ++S L A IR +K + D E
Sbjct: 1573 KSEVDRKI--AEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEME 1630
Query: 323 LQ--------EEAARLKSHFQAQL---QQEMRKTALAEDQLRQQSQVEEQRVAALENQIS 371
+Q EA R + QA L Q + +++ L++Q + E+R L+ +
Sbjct: 1631 IQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQ---A 1687
Query: 372 EVSELLGTYEKAKQKDQLAIQKL---KERILQLDLENKTLALAASSRSPLDSHGEESSLD 428
E+ EL T E+ ++ ++A Q+L ER+ L +N +L +++ L++ D
Sbjct: 1688 EIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSL---INTKKKLET-------D 1737
Query: 429 VNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQL 488
++ ++ +ME + + + A K++ + + E+ + + + +Q +K L
Sbjct: 1738 ISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDL 1797
Query: 489 KEEFERYKMRA----QVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQ 544
+ + + A + ++ + L E+E+ Q++ E + +EL +Q
Sbjct: 1798 QHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQ 1857
Query: 545 HQQEADDWKQELARLQQL 562
+++ ++ + RLQ L
Sbjct: 1858 TEED----RKNILRLQDL 1871
Score = 55.1 bits (131), Expect = 2e-07
Identities = 72/341 (21%), Positives = 134/341 (39%), Gaps = 28/341 (8%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDAS---NKAEEERA 209
E D+ + Q+K + S+ + + R + KKKM+ DL + N A A
Sbjct: 1582 EKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAA 1641
Query: 210 RLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLE 269
+ Q + +T+ L + + A++ R L E R LE
Sbjct: 1642 EALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTER 1701
Query: 270 ETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAAR 329
+ A A+E+++ Q L ++L++++ I+ E + +E+A +
Sbjct: 1702 SRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKK 1761
Query: 330 LKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQL 389
+ A + +E++K L + + EQ V L++++ E +L A + +
Sbjct: 1762 AITD-AAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL------ALKGGKK 1814
Query: 390 AIQKLKERILQLDLE-----------NKTLALAASSRSPLDSHGEESSLDVNVLKDKMEK 438
IQKL+ R+ +L+ E K L L EE ++ L+D ++K
Sbjct: 1815 QIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDK 1874
Query: 439 L-------KRLLQVAARKSQVTLDVEKLCDLEIMPSSEAAD 472
L KR + A +S V L + E+ + E AD
Sbjct: 1875 LQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERAD 1915
Score = 38.5 bits (88), Expect = 0.024
Identities = 59/262 (22%), Positives = 111/262 (42%), Gaps = 49/262 (18%)
Query: 463 EIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQE 522
+I P ++A+ EK E+ +KEEFE+ K +EL +
Sbjct: 839 KIKPLLKSAETEK--------EMANMKEEFEKTK------------------EELAKTEA 872
Query: 523 QLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLE 582
+ EL+EK ++L +L+ Q Q EAD R QL + +++ + ++ T + E
Sbjct: 873 KRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQ-LEAKIKEVTERAE 931
Query: 583 EELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQA 642
+E + A LT K +LE S L + + A + +LT+
Sbjct: 932 DE-----EEINAELTAKKRKLEDECS-ELKKDIDDLELTLAKVEKEKHATENKVKNLTE- 984
Query: 643 LQLAAANEPTFFLYAEQLARKEV-------------EITSLRKQKHRLEVEVHQLQDRLL 689
++A +E L E+ A +E ++ +L K K +LE +V L+ L
Sbjct: 985 -EMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGS-L 1042
Query: 690 EEGERHREEVAALQSHIEKNIR 711
E+ ++ R ++ + +E +++
Sbjct: 1043 EQEKKIRMDLERAKRKLEGDLK 1064
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 89.0 bits (219), Expect = 2e-17
Identities = 142/616 (23%), Positives = 262/616 (42%), Gaps = 72/616 (11%)
Query: 153 EVDKRLHQL---KTQLATLTSSLATVTQEKSRMEASYLADKKKM-------KQDLEDAS- 201
+ ++R H L K QL L+ +++ + A A ++K+ K+D++D
Sbjct: 949 DAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKL 1008
Query: 202 --NKAEEERARLEGELKGLQEQIA---ETKARLITQQHDRAQEQSDHAL--------MLR 248
KAE+E+ E ++K L E++A E+ ARL T++ QE AL +
Sbjct: 1009 TLAKAEKEKQATENKVKNLTEEMAALDESVARL-TKEKKALQEAHQQALGDLQAEEDRVS 1067
Query: 249 ELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQA 308
L K Q +DLE LE+ ++ A ++EG T++ + + K +L+
Sbjct: 1068 ALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEE 1127
Query: 309 IRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQ----SQVEEQRVA 364
+K+ +L E+ L + Q ++++ + E++L + ++VE+QR
Sbjct: 1128 KLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAE 1187
Query: 365 ALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALA-ASSRSPLDSHGE 423
A ++ E+SE L A + +K + + +L E + AL ++ + L
Sbjct: 1188 A-ARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQA 1246
Query: 424 ESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKL-CDLEIMPSSEAADGEKATALYYQ 482
E + ++ D ++++++ L+ KS++ ++V+ L ++E + ++A+ EK Y
Sbjct: 1247 EGAAELGEQVDSLQRVRQKLE--KEKSELRMEVDDLAANVETLTRAKAS-AEKLCRTYED 1303
Query: 483 Q--ELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEE 540
Q E K EE +R A T+ G L + LE + +++L S EE
Sbjct: 1304 QLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEE 1363
Query: 541 LEHQHQQEADDWKQELAR-----------LQQLHRQELERCQLDFRDRTLKLEEELHKQR 589
L Q ++E+ K LA L++ H +E E Q + + K E+ + R
Sbjct: 1364 LRRQLEEESKA-KSALAHAVQALRHDCDLLREQHEEEAE-AQAELQRLLSKANAEVAQWR 1421
Query: 590 DRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAAN 649
+ A ++ ELE+ + LA L V + A+ S L+L +
Sbjct: 1422 SKYEADAIQRTEELEEAKK-KLALRLQEAEEGV------EAANAKCSSLEKAKLRLQTES 1474
Query: 650 EPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKN 709
E +L R +L K++ LE R LEE R EE +Q +E
Sbjct: 1475 EDVTL----ELERATSAAAALDKKQRHLE--------RALEERRRQEEE---MQRELEAA 1519
Query: 710 IRDQSREGANLEYLKN 725
R+ G L L++
Sbjct: 1520 QRESRGLGTELFRLRH 1535
Score = 86.3 bits (212), Expect = 1e-16
Identities = 145/580 (25%), Positives = 241/580 (41%), Gaps = 84/580 (14%)
Query: 192 KMKQDLEDASNKAEEERARLEGELKGLQEQI--AETKARLITQQH-DRAQEQSDHALMLR 248
KMK L A +AEEE A L EL+GL+ + AE K + + + H QE++D AL L+
Sbjct: 884 KMKPLLRSA--QAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQ 941
Query: 249 ELQKLL--QEERT------------QRQDLELRLEETREALAGRAYAAEQMEGFELQTKQ 294
Q L EER + ++L RLE+ E A A ++E + +
Sbjct: 942 AEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLED---ECTE 998
Query: 295 LTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQ 354
L +++++LK L EK + +++ L EE A L A+L +E + A Q
Sbjct: 999 LKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESV-ARLTKEKKALQEAHQQALG 1057
Query: 355 QSQVEEQRVAA-------LENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKT 407
Q EE RV+A LE Q+ ++ L +K + + A +KL+ L L ++
Sbjct: 1058 DLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEG---DLKLTQES 1114
Query: 408 LALAASSRSPL-------DSHGEESSL---DVNVLKDKMEKLKRLLQVAARKSQVTLDVE 457
+A AA + L DS + SL D +L +M+K + LQ A + + L+ E
Sbjct: 1115 VADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAE 1174
Query: 458 KLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKEL 517
+ + + ++A A +EL + EE + + + + G L +EL
Sbjct: 1175 RAARARV-------EKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRREL 1227
Query: 518 EAA---------------QEQLAELKEKYISLRLSCEELEHQHQQ---EADDWKQELARL 559
E A E AEL E+ SL+ ++LE + + E DD + L
Sbjct: 1228 EEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETL 1287
Query: 560 QQLHRQELERCQL---DFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLP 616
+ + C+ + +K+EE QR A A L+ E S L+ L
Sbjct: 1288 TRAKASAEKLCRTYEDQLSEAKIKVEE---LQRQLADASTQRGRLQTE---SGELSRLLE 1341
Query: 617 GRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHR 676
+ + G S + L + L+ + + +A Q R + + L +++H
Sbjct: 1342 EKECLISQLSRGKALAAQSLEELRRQLE-EESKAKSALAHAVQALRHDCD---LLREQHE 1397
Query: 677 LEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQSRE 716
E E RLL + EVA +S E + ++ E
Sbjct: 1398 EEAEAQAELQRLLSKA---NAEVAQWRSKYEADAIQRTEE 1434
Score = 76.6 bits (187), Expect = 8e-14
Identities = 199/931 (21%), Positives = 355/931 (38%), Gaps = 227/931 (24%)
Query: 19 ETIETQKKQLLQYQARLKDVVRAYKSLLKEKEAL-EASIKVLSVSHEADVGLAGVQLPGL 77
+ E + K L + A L + V L KEK+AL EA + L + ++ + L
Sbjct: 1018 QATENKVKNLTEEMAALDESVAR---LTKEKKALQEAHQQALGDLQAEEDRVSALTKAKL 1074
Query: 78 TFPDSVDD-RCSTHSE-----DSTGTATSLDTAASLTSTKGEFGVEDDRPARGPPPPKSE 131
V+D CS E D+ L+ LT +D + K
Sbjct: 1075 RLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDS 1134
Query: 132 EASWSESGVSSSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKSRME---ASYLA 188
E S V D G ++ K++ +L+ + L L ++R+E A
Sbjct: 1135 ELSQLSLRVE----DEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAAR 1190
Query: 189 DKKKMKQDLEDASN----------KAEEERARLEGELKGLQEQIAETKARLITQQHDRAQ 238
+ +++ + LE+A K E E RL EL+ + T A L +Q + A
Sbjct: 1191 ELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAA 1250
Query: 239 EQSDHALMLRELQKLLQEERTQRQ----DLELRLEETREALAG-----RAYAAEQMEGFE 289
E + L+ +++ L++E+++ + DL +E A A R Y +Q+ +
Sbjct: 1251 ELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYE-DQLSEAK 1309
Query: 290 LQTKQLTREVEELKS----------ELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQ 339
++ ++L R++ + + EL + +EK +L + AA+ + QL+
Sbjct: 1310 IKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLE 1369
Query: 340 QEMR-KTALAE---------DQLRQQSQVEEQRVAALENQIS----EVSELLGTYE---- 381
+E + K+ALA D LR+Q + E + A L+ +S EV++ YE
Sbjct: 1370 EESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAI 1429
Query: 382 -------KAKQKDQLAIQKLKERI----------------LQLDLENKTLAL--AASSRS 416
+AK+K L +Q+ +E + LQ + E+ TL L A S+ +
Sbjct: 1430 QRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAA 1489
Query: 417 PLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKS-------------------------- 450
LD + + + E+++R L+ A R+S
Sbjct: 1490 ALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKR 1549
Query: 451 --------------QVTLDVEKLCDLEIMPSSEAADGEK---------ATALYYQQELKQ 487
QV+L + + +LE + +A +GEK A +E K
Sbjct: 1550 ENKNLQEEISDLTDQVSLSGKSIQELE--KTKKALEGEKSEIQAALEEAEGALELEETKT 1607
Query: 488 LKEEFERYKMRAQV--VLKSKNTKDGNLGKELEAAQEQL-----AELKEKYISLRLSCE- 539
L+ + E +++A+V L K+ + NL + + A E L AE + + +LRL +
Sbjct: 1608 LRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKM 1667
Query: 540 -------ELEHQHQQEADDWKQELARLQQ-------------------LHRQ-------- 565
EL+ H Q RL Q LH Q
Sbjct: 1668 EGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRA 1727
Query: 566 -----ELE--RCQLDFRDRTLKLEEE-----------LHKQRDRALAVLTEKDLELEQLR 607
ELE R L+ +R+ +L E+ LH Q L + + +L QL
Sbjct: 1728 SLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLS 1787
Query: 608 SVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYA-----EQLAR 662
+ R + + A + +D+ A +L + + L EQ R
Sbjct: 1788 GEVEEAAQERREAE-------EKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVR 1840
Query: 663 K------EVEITSLR---KQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRD- 712
+ E E +LR KQ +LE +V +L+ L E ++H E + ++ H E+ +++
Sbjct: 1841 ELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKH-ERRVKEL 1899
Query: 713 ---QSREGANLEYLKNIIYRFLTLPDSLGRQ 740
+ NL +++++ + + S RQ
Sbjct: 1900 AYQAEEDRKNLARMQDLVDKLQSKVKSYKRQ 1930
Score = 57.0 bits (136), Expect = 7e-08
Identities = 118/544 (21%), Positives = 203/544 (37%), Gaps = 73/544 (13%)
Query: 46 LKEKEALEASIKVLSVS-HEADVGLAGVQLPGLTFPDSVDDRCSTHSEDST---GTATSL 101
++ E LE + K L++ EA+ G+ + + R T SED T ATS
Sbjct: 1429 IQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSL-EKAKLRLQTESEDVTLELERATSA 1487
Query: 102 DTAASLTSTKGEFGVEDDRPARGPPPPKSEEASWSESGVSSSSGDGPFAGGEVDKRLHQL 161
A E +E+ R + E A G+ + E + L L
Sbjct: 1488 AAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETL 1547
Query: 162 KTQLATLTSSLATVT----------QEKSRMEASYLADKKKMKQDLEDASNKAE-EERAR 210
K + L ++ +T QE + + + +K +++ LE+A E EE
Sbjct: 1548 KRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKT 1607
Query: 211 LEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQ-------- 262
L +L+ L + AE +L + + A + +H + LQ L E R
Sbjct: 1608 LRIQLE-LSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKK 1666
Query: 263 ------DLELRL------------------EETREALAGR-------AYAAEQMEGFELQ 291
DLEL+L + +E AGR A EQ + E +
Sbjct: 1667 MEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERR 1726
Query: 292 TKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQ 351
L E+EEL++ L+ + + L E E L S L Q K L D
Sbjct: 1727 ASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQ---KKKLEADL 1783
Query: 352 LRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALA 411
+ +VEE AA E + +E + A ++L +K ++ L+ KTL
Sbjct: 1784 AQLSGEVEE---AAQERREAEEKAKKAITDAAMMAEEL--KKEQDTSAHLERMKKTLEQT 1838
Query: 412 ASSRSPLDSHGEESSL-----DVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMP 466
E+++L V L+ K+ +L+ L +K L + + +
Sbjct: 1839 VRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKE 1898
Query: 467 SSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAE 526
+ A+ ++ Q + +L+ + + YK + + + NT NL K AQ +L +
Sbjct: 1899 LAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANT---NLAK-YRKAQHELDD 1954
Query: 527 LKEK 530
+E+
Sbjct: 1955 AEER 1958
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 88.6 bits (218), Expect = 2e-17
Identities = 96/393 (24%), Positives = 174/393 (44%), Gaps = 41/393 (10%)
Query: 154 VDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEG 213
++ ++ ++KTQL L L K R+E + A K + ++DL+ + EE+R +L+
Sbjct: 1537 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1596
Query: 214 ELKGLQEQIA-ETKARLITQQHDRAQE--------QSDHALMLR-ELQKLLQEERTQRQD 263
+L + ++ E K R + + E Q+D A+ R E K L++ + Q +D
Sbjct: 1597 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1656
Query: 264 LELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQEL 323
+ LE+ R A R + E + K L ++ +L+ +L A + Q D +EL
Sbjct: 1657 FQRELEDAR---ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1713
Query: 324 QEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEE-------QRVAALENQISEVSEL 376
EE A S A LQ E R+ QL ++ + E+ RV Q ++S
Sbjct: 1714 AEELASSLSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1772
Query: 377 LGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKM 436
L T QK++ A Q+L+ + +L +K + + +S S + L+ K+
Sbjct: 1773 LATERSTAQKNESARQQLERQ--NKELRSKLHEMEGAVKSKFKS-------TIAALEAKI 1823
Query: 437 EKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQE-------LKQLK 489
+L+ ++ AR+ Q K D ++ + E+ A Y+++ +KQLK
Sbjct: 1824 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1883
Query: 490 EEFERYKMRAQVVLKSKNTKDGNLGKELEAAQE 522
+ E + +Q + N L +EL+ A E
Sbjct: 1884 RQLEEAEEESQRI----NANRRKLQRELDEATE 1912
Score = 84.7 bits (208), Expect = 3e-16
Identities = 147/700 (21%), Positives = 285/700 (40%), Gaps = 128/700 (18%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERA--- 209
E+ RL K +L + + +E+ A++KKM Q + D + EEE A
Sbjct: 908 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ 967
Query: 210 ----------------------------RLEGELKGLQEQIAETKARLITQQHDRAQE-- 239
+L E K L+E+I++ L ++ ++A+
Sbjct: 968 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL-AEEEEKAKNLT 1026
Query: 240 --QSDHALMLRELQKLLQEERTQRQDLE-------------------------------- 265
++ H M+ EL+ L++E RQ+LE
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1086
Query: 266 LRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQE 325
+ EE + ALA Q + ++L + +L+ +L + R +N+ + + ++L E
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146
Query: 326 EAARLKSHFQAQL-----QQEMR----------KTALAEDQLRQQSQVEEQRVAALENQI 370
E LK+ + L QQE+R K AL E+ ++QV+E R + +
Sbjct: 1147 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ-AV 1205
Query: 371 SEVSELLGTYEKAK---QKDQLAIQK-----------LKERILQLDLENKTLALAASSRS 416
E++E L +++AK K++ ++K L + +++ + K L
Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Query: 417 PLDSHGEESSLDVN----VLKDKMEKLKRLLQVAARKS-QVTLDVEKLCDLEIMPSSEAA 471
S GE + ++N L++++E + +L A K+ ++ DV L ++ + E
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS-QLQDTQELL 1324
Query: 472 DGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKY 531
E L +L+QL+EE + + +++K NL + + QL++ K+K
Sbjct: 1325 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ----NLERHISTLNIQLSDSKKKL 1380
Query: 532 ISLRLSCEELEH---QHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHKQ 588
+ E LE + Q+E ++ Q+ + +LE+ + + L +L Q
Sbjct: 1381 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-DKLEKTKNRLQQELDDLVVDLDNQ 1439
Query: 589 RDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAA 648
R + ++ L +K + +QL +A + + + D A+ + + T+AL LA A
Sbjct: 1440 R-QLVSNLEKKQRKFDQL--LAEEKNISSKYA-----DERDRAEAEAREKETKALSLARA 1491
Query: 649 NEPTFFLYAEQLARK----EVEITSLRKQKHRLEVEVHQLQ--DRLLE-EGERHREEVAA 701
E E+L R + E+ L K + VH+L+ R LE + E + ++
Sbjct: 1492 LEEALEA-KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1550
Query: 702 LQSHIEKNIRDQSREGANLEYLKNIIYRFLTLPDSLGRQQ 741
L+ ++ + R N++ LK R L D ++
Sbjct: 1551 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590
Score = 80.9 bits (198), Expect = 4e-15
Identities = 136/591 (23%), Positives = 265/591 (44%), Gaps = 108/591 (18%)
Query: 156 KRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGEL 215
+R + + +L L + +T+EK+ ++ A+ + + AEE R RL +
Sbjct: 866 ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE--------AEEMRVRLAAKK 917
Query: 216 KGLQEQIAETKARLITQQHDRAQ----EQSDHALMLRELQKLLQEERTQRQDLELRLEET 271
+ L+E + E +ARL ++ DR Q E+ A + +L++ L+EE RQ L+L + T
Sbjct: 918 QELEEILHEMEARL-EEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE-KVT 975
Query: 272 REALAGRAYAAEQMEGFELQTKQLTRE---VEELKSELQAIRDEKNQPDPRLQELQEEAA 328
EA + +++ + Q +L++E +EE S+L E+ + L +L+ +
Sbjct: 976 AEAKIKK--LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1033
Query: 329 RLKSHFQAQLQQEMRKTALAED---QLRQQSQVEEQRVAALENQISEVSELLGTYEK--- 382
+ S + +L++E + E +L + +++A L+ QI+E+ L E+
Sbjct: 1034 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ 1093
Query: 383 ---AKQKDQL-----AIQKLKE-----RILQLDLENKTLALAASSRSPLDSHGEESSLDV 429
A+ D++ A++K++E LQ DL+++ A + + D GEE
Sbjct: 1094 AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL-GEELEALK 1152
Query: 430 NVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLK 489
L+D ++ ++ A++ Q ++K D E S EA E + Q +++L
Sbjct: 1153 TELEDTLDSTATQQELRAKREQEVTVLKKALDEETR-SHEAQVQEMRQK--HAQAVEELT 1209
Query: 490 EEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEA 549
E+ E++K RA+ NL K + +++ A+L + L + +E+EH+
Sbjct: 1210 EQLEQFK-RAK----------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK---- 1254
Query: 550 DDWKQELARLQQLHRQ--ELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLR 607
K+ A++Q+L + + ER + + D+ KL+ E+ + +L E + +
Sbjct: 1255 ---KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV----ESVTGMLNE-----AEGK 1302
Query: 608 SVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEI 667
++ LA D A SS TQ L ++ R+++ +
Sbjct: 1303 AIKLAK---------------DVASLSSQLQDTQEL-------------LQEETRQKLNV 1334
Query: 668 TSLRKQKHRLEVEVHQLQDRLLEEG------ERHREEVAALQSHIEKNIRD 712
++ +Q LE E + LQD+L EE ERH + S +K ++D
Sbjct: 1335 STKLRQ---LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1382
Score = 78.6 bits (192), Expect = 2e-14
Identities = 129/632 (20%), Positives = 267/632 (42%), Gaps = 82/632 (12%)
Query: 14 KKDLLETIETQKKQLLQYQARLKDVVRAYKSLLKEKEALEASIKVLSVSHEADVGLAGVQ 73
K +L +T+++ Q R ++V K+L +E + EA ++ + H V Q
Sbjct: 1152 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1211
Query: 74 LPGLTFPDS-VDDRCSTHSEDSTGTATSLDTAASLTSTKGEFGVEDDRPARGPPPPKSEE 132
L + +D T +++ A GE V K E
Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLA-------------GELRVLGQAKQEVEHKKKKLE 1258
Query: 133 ASWSESGVSSSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKK 192
A E + S DG A E++ ++H+L+ ++ ++T L + E + K
Sbjct: 1259 AQVQE--LQSKCSDGERARAELNDKVHKLQNEVESVTGML-------NEAEGKAI----K 1305
Query: 193 MKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRE-LQ 251
+ +D+ S++ ++ + L+ E + Q+ TK R + ++ + Q+Q D + ++ L+
Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETR--QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363
Query: 252 KLLQEERTQRQDLELRLEE---TREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQA 308
+ + Q D + +L++ T EAL E + F+ + + LT++ EE +
Sbjct: 1364 RHISTLNIQLSDSKKKLQDFASTVEAL------EEGKKRFQKEIENLTQQYEEKAAAYDK 1417
Query: 309 IRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRK------------TALAEDQLRQQS 356
+ KN+ L +L + + + L+++ RK + A+++ R ++
Sbjct: 1418 LEKTKNRLQQELDDLVVDLDN-QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476
Query: 357 QVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRS 416
+ E+ AL + + E L E+ ++ +++ ++++ + D K + S+
Sbjct: 1477 EAREKETKAL-SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535
Query: 417 PLDSHGEESSLDVNVLKDKME-----KLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAA 471
L++ EE + L+D+++ KL+ + + A K Q D++ + +
Sbjct: 1536 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQ---------ARDEQ 1586
Query: 472 DGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKY 531
+ EK L Q++L + + E E + + + +K +G+L K+LE + + +E+
Sbjct: 1587 NEEKRRQL--QRQLHEYETELEDERKQRALAAAAKKKLEGDL-KDLELQADSAIKGREEA 1643
Query: 532 ISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHK-QRD 590
I + Q+E +D + R E+ + + LE +L + Q D
Sbjct: 1644 IKQLRKLQAQMKDFQRELED--------ARASRDEIFATAKENEKKAKSLEADLMQLQED 1695
Query: 591 RALAVLTEK--DLELEQLRSVALASGLPGRRS 620
A A K DLE E+L + LAS L GR +
Sbjct: 1696 LAAAERARKQADLEKEEL-AEELASSLSGRNA 1726
Score = 76.6 bits (187), Expect = 8e-14
Identities = 131/640 (20%), Positives = 235/640 (36%), Gaps = 128/640 (20%)
Query: 154 VDKRLHQLKTQLATLTSSLATVTQEKSRMEASY------LADKKKMKQDLEDASNKAEEE 207
V +L QL+ + +L L + K +E L+D KK QD EE
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1393
Query: 208 RARLEGELKGLQEQIAE----------TKARLITQQHDRAQEQSDHALMLRELQK----- 252
+ R + E++ L +Q E TK RL + D + + ++ L+K
Sbjct: 1394 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1453
Query: 253 --LLQEERT---------QRQDLELRLEETREALAGRAY--AAEQMEGFELQTKQLTREV 299
LL EE+ R + E R +ET+ RA A E E E K L E+
Sbjct: 1454 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1513
Query: 300 E----------------------------ELKSELQAIRDEKNQPDPRLQELQEEAARLK 331
E E+K++L+ + DE + L+ LK
Sbjct: 1514 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK 1573
Query: 332 SHFQAQLQQEMRKTALAEDQLRQQ-----SQVEEQR------VAALENQISEVSELLGTY 380
F+ LQ + QL++Q +++E++R AA + ++ +L
Sbjct: 1574 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA 1633
Query: 381 EKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLK 440
+ A + + AI++L++ Q+ + L A +SR + + +E+ L+ + +L+
Sbjct: 1634 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ 1693
Query: 441 RLLQVAAR-KSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRA 499
L A R + Q L+ E+L + E A++L + L+ K E
Sbjct: 1694 EDLAAAERARKQADLEKEELAE------------ELASSLSGRNALQDEKRRLE------ 1735
Query: 500 QVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARL 559
+ L +ELE Q + + ++ E+L ++ E + A+
Sbjct: 1736 --------ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE-----RSTAQK 1782
Query: 560 QQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRR 619
+ RQ+LER + R + ++E + + +A L K +LE+ +
Sbjct: 1783 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1842
Query: 620 SPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFF-LYAEQLARKEVEITSLRKQKHRLE 678
S D + + L +E Y EQ + + L++Q E
Sbjct: 1843 S------------LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAE 1890
Query: 679 VEVHQLQ----------DRLLEEGERHREEVAALQSHIEK 708
E ++ D E E EV AL+S + +
Sbjct: 1891 EESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930
Score = 72.8 bits (177), Expect = 1e-12
Identities = 117/498 (23%), Positives = 215/498 (43%), Gaps = 80/498 (16%)
Query: 246 MLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSE 305
+ +++ LLQ R Q ++++ + +E ++ + A +++ E + QLT E L+ +
Sbjct: 837 LFTKVKPLLQVTR-QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895
Query: 306 LQA---IRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQR 362
LQA + E + RL ++E + +A+L++E ED+ QQ Q E ++
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE-------EDR-GQQLQAERKK 947
Query: 363 VAALENQISEVSELLGTYEKAKQKDQL-------AIQKLKERILQLDLENKTLA----LA 411
+A Q+ ++ E L E A+QK QL I+KL++ IL +D +N L+ L
Sbjct: 948 MA---QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1004
Query: 412 ASSRSPLDSH---GEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSS 468
S L ++ EE + ++ LK+K E + L+V +K + + ++L L+
Sbjct: 1005 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR--QELEKLKRKLEG 1062
Query: 469 EAADGEKATALYYQQ--ELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAE 526
+A+D + A Q ELK + E A L + + N K++ + +++
Sbjct: 1063 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1122
Query: 527 LKEKYISLRLSCEELEHQHQQ----------EADDWKQELARLQQL---HRQELERCQLD 573
L+E S R + + E Q + E +D A Q+L QE+ +
Sbjct: 1123 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1182
Query: 574 FRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPADT 633
+ T E ++ + R + + E +LEQ +
Sbjct: 1183 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-----------------------K 1219
Query: 634 SSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGE 693
++ D Q L+ A+ Q A++EVE +K +LE +V +LQ + +GE
Sbjct: 1220 ANLDKNKQTLEKENADLAGELRVLGQ-AKQEVE-----HKKKKLEAQVQELQSK-CSDGE 1272
Query: 694 RHREE----VAALQSHIE 707
R R E V LQ+ +E
Sbjct: 1273 RARAELNDKVHKLQNEVE 1290
Score = 39.3 bits (90), Expect = 0.014
Identities = 62/312 (19%), Positives = 123/312 (39%), Gaps = 33/312 (10%)
Query: 26 KQLLQYQARLKDVVRAYKSLLKEKEALEASIKV---LSVSHEADVGLAGVQLPGLTFPDS 82
KQL + QA++KD R + ++ + A+ K + S EAD+ +QL
Sbjct: 1645 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL----MQLQ------- 1693
Query: 83 VDDRCSTHSEDSTGTATSLDTAASLTST-KGEFGVEDDRPARGPPPPKSEEASWSESGVS 141
+D + + A L S+ G ++D++ + EE E G
Sbjct: 1694 -EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM 1752
Query: 142 SSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDAS 201
+ D + ++ QL +LAT S+ + ++E + K+ +
Sbjct: 1753 EAMSDRV---RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVK 1809
Query: 202 NKAEEERARLEGELKGLQEQI---AETKARLITQQHDRAQEQSDHALMLRELQKLLQEER 258
+K + A LE ++ L+EQ+ A K + ++ + L + + +K+ ++ +
Sbjct: 1810 SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYK 1869
Query: 259 TQ-----------RQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQ 307
Q ++ LE EE++ A R +++ + + REV LKS+L+
Sbjct: 1870 EQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Query: 308 AIRDEKNQPDPR 319
+ P R
Sbjct: 1930 RGNETSFVPSRR 1941
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 88.6 bits (218), Expect = 2e-17
Identities = 96/393 (24%), Positives = 174/393 (44%), Gaps = 41/393 (10%)
Query: 154 VDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEG 213
++ ++ ++KTQL L L K R+E + A K + ++DL+ + EE+R +L+
Sbjct: 1544 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1603
Query: 214 ELKGLQEQIA-ETKARLITQQHDRAQE--------QSDHALMLR-ELQKLLQEERTQRQD 263
+L + ++ E K R + + E Q+D A+ R E K L++ + Q +D
Sbjct: 1604 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1663
Query: 264 LELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQEL 323
+ LE+ R A R + E + K L ++ +L+ +L A + Q D +EL
Sbjct: 1664 FQRELEDAR---ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720
Query: 324 QEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEE-------QRVAALENQISEVSEL 376
EE A S A LQ E R+ QL ++ + E+ RV Q ++S
Sbjct: 1721 AEELASSLSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1779
Query: 377 LGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKM 436
L T QK++ A Q+L+ + +L +K + + +S S + L+ K+
Sbjct: 1780 LATERSTAQKNESARQQLERQ--NKELRSKLHEMEGAVKSKFKS-------TIAALEAKI 1830
Query: 437 EKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQE-------LKQLK 489
+L+ ++ AR+ Q K D ++ + E+ A Y+++ +KQLK
Sbjct: 1831 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1890
Query: 490 EEFERYKMRAQVVLKSKNTKDGNLGKELEAAQE 522
+ E + +Q + N L +EL+ A E
Sbjct: 1891 RQLEEAEEESQRI----NANRRKLQRELDEATE 1919
Score = 84.7 bits (208), Expect = 3e-16
Identities = 147/700 (21%), Positives = 285/700 (40%), Gaps = 128/700 (18%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERA--- 209
E+ RL K +L + + +E+ A++KKM Q + D + EEE A
Sbjct: 915 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ 974
Query: 210 ----------------------------RLEGELKGLQEQIAETKARLITQQHDRAQE-- 239
+L E K L+E+I++ L ++ ++A+
Sbjct: 975 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL-AEEEEKAKNLT 1033
Query: 240 --QSDHALMLRELQKLLQEERTQRQDLE-------------------------------- 265
++ H M+ EL+ L++E RQ+LE
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1093
Query: 266 LRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQE 325
+ EE + ALA Q + ++L + +L+ +L + R +N+ + + ++L E
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153
Query: 326 EAARLKSHFQAQL-----QQEMR----------KTALAEDQLRQQSQVEEQRVAALENQI 370
E LK+ + L QQE+R K AL E+ ++QV+E R + +
Sbjct: 1154 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ-AV 1212
Query: 371 SEVSELLGTYEKAK---QKDQLAIQK-----------LKERILQLDLENKTLALAASSRS 416
E++E L +++AK K++ ++K L + +++ + K L
Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 417 PLDSHGEESSLDVN----VLKDKMEKLKRLLQVAARKS-QVTLDVEKLCDLEIMPSSEAA 471
S GE + ++N L++++E + +L A K+ ++ DV L ++ + E
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS-QLQDTQELL 1331
Query: 472 DGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKY 531
E L +L+QL+EE + + +++K NL + + QL++ K+K
Sbjct: 1332 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ----NLERHISTLNIQLSDSKKKL 1387
Query: 532 ISLRLSCEELEH---QHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHKQ 588
+ E LE + Q+E ++ Q+ + +LE+ + + L +L Q
Sbjct: 1388 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-DKLEKTKNRLQQELDDLVVDLDNQ 1446
Query: 589 RDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAA 648
R + ++ L +K + +QL +A + + + D A+ + + T+AL LA A
Sbjct: 1447 R-QLVSNLEKKQRKFDQL--LAEEKNISSKYA-----DERDRAEAEAREKETKALSLARA 1498
Query: 649 NEPTFFLYAEQLARK----EVEITSLRKQKHRLEVEVHQLQ--DRLLE-EGERHREEVAA 701
E E+L R + E+ L K + VH+L+ R LE + E + ++
Sbjct: 1499 LEEALEA-KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1557
Query: 702 LQSHIEKNIRDQSREGANLEYLKNIIYRFLTLPDSLGRQQ 741
L+ ++ + R N++ LK R L D ++
Sbjct: 1558 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597
Score = 80.9 bits (198), Expect = 4e-15
Identities = 136/591 (23%), Positives = 265/591 (44%), Gaps = 108/591 (18%)
Query: 156 KRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGEL 215
+R + + +L L + +T+EK+ ++ A+ + + AEE R RL +
Sbjct: 873 ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE--------AEEMRVRLAAKK 924
Query: 216 KGLQEQIAETKARLITQQHDRAQ----EQSDHALMLRELQKLLQEERTQRQDLELRLEET 271
+ L+E + E +ARL ++ DR Q E+ A + +L++ L+EE RQ L+L + T
Sbjct: 925 QELEEILHEMEARL-EEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE-KVT 982
Query: 272 REALAGRAYAAEQMEGFELQTKQLTRE---VEELKSELQAIRDEKNQPDPRLQELQEEAA 328
EA + +++ + Q +L++E +EE S+L E+ + L +L+ +
Sbjct: 983 AEAKIKK--LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040
Query: 329 RLKSHFQAQLQQEMRKTALAED---QLRQQSQVEEQRVAALENQISEVSELLGTYEK--- 382
+ S + +L++E + E +L + +++A L+ QI+E+ L E+
Sbjct: 1041 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ 1100
Query: 383 ---AKQKDQL-----AIQKLKE-----RILQLDLENKTLALAASSRSPLDSHGEESSLDV 429
A+ D++ A++K++E LQ DL+++ A + + D GEE
Sbjct: 1101 AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL-GEELEALK 1159
Query: 430 NVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLK 489
L+D ++ ++ A++ Q ++K D E S EA E + Q +++L
Sbjct: 1160 TELEDTLDSTATQQELRAKREQEVTVLKKALDEETR-SHEAQVQEMRQK--HAQAVEELT 1216
Query: 490 EEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEA 549
E+ E++K RA+ NL K + +++ A+L + L + +E+EH+
Sbjct: 1217 EQLEQFK-RAK----------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK---- 1261
Query: 550 DDWKQELARLQQLHRQ--ELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLR 607
K+ A++Q+L + + ER + + D+ KL+ E+ + +L E + +
Sbjct: 1262 ---KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV----ESVTGMLNE-----AEGK 1309
Query: 608 SVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEI 667
++ LA D A SS TQ L ++ R+++ +
Sbjct: 1310 AIKLAK---------------DVASLSSQLQDTQEL-------------LQEETRQKLNV 1341
Query: 668 TSLRKQKHRLEVEVHQLQDRLLEEG------ERHREEVAALQSHIEKNIRD 712
++ +Q LE E + LQD+L EE ERH + S +K ++D
Sbjct: 1342 STKLRQ---LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389
Score = 78.6 bits (192), Expect = 2e-14
Identities = 129/632 (20%), Positives = 267/632 (42%), Gaps = 82/632 (12%)
Query: 14 KKDLLETIETQKKQLLQYQARLKDVVRAYKSLLKEKEALEASIKVLSVSHEADVGLAGVQ 73
K +L +T+++ Q R ++V K+L +E + EA ++ + H V Q
Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218
Query: 74 LPGLTFPDS-VDDRCSTHSEDSTGTATSLDTAASLTSTKGEFGVEDDRPARGPPPPKSEE 132
L + +D T +++ A GE V K E
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLA-------------GELRVLGQAKQEVEHKKKKLE 1265
Query: 133 ASWSESGVSSSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKK 192
A E + S DG A E++ ++H+L+ ++ ++T L + E + K
Sbjct: 1266 AQVQE--LQSKCSDGERARAELNDKVHKLQNEVESVTGML-------NEAEGKAI----K 1312
Query: 193 MKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRE-LQ 251
+ +D+ S++ ++ + L+ E + Q+ TK R + ++ + Q+Q D + ++ L+
Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETR--QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370
Query: 252 KLLQEERTQRQDLELRLEE---TREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQA 308
+ + Q D + +L++ T EAL E + F+ + + LT++ EE +
Sbjct: 1371 RHISTLNIQLSDSKKKLQDFASTVEAL------EEGKKRFQKEIENLTQQYEEKAAAYDK 1424
Query: 309 IRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRK------------TALAEDQLRQQS 356
+ KN+ L +L + + + L+++ RK + A+++ R ++
Sbjct: 1425 LEKTKNRLQQELDDLVVDLDN-QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483
Query: 357 QVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRS 416
+ E+ AL + + E L E+ ++ +++ ++++ + D K + S+
Sbjct: 1484 EAREKETKAL-SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542
Query: 417 PLDSHGEESSLDVNVLKDKME-----KLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAA 471
L++ EE + L+D+++ KL+ + + A K Q D++ + +
Sbjct: 1543 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQ---------ARDEQ 1593
Query: 472 DGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKY 531
+ EK L Q++L + + E E + + + +K +G+L K+LE + + +E+
Sbjct: 1594 NEEKRRQL--QRQLHEYETELEDERKQRALAAAAKKKLEGDL-KDLELQADSAIKGREEA 1650
Query: 532 ISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHK-QRD 590
I + Q+E +D + R E+ + + LE +L + Q D
Sbjct: 1651 IKQLRKLQAQMKDFQRELED--------ARASRDEIFATAKENEKKAKSLEADLMQLQED 1702
Query: 591 RALAVLTEK--DLELEQLRSVALASGLPGRRS 620
A A K DLE E+L + LAS L GR +
Sbjct: 1703 LAAAERARKQADLEKEEL-AEELASSLSGRNA 1733
Score = 76.6 bits (187), Expect = 8e-14
Identities = 131/640 (20%), Positives = 235/640 (36%), Gaps = 128/640 (20%)
Query: 154 VDKRLHQLKTQLATLTSSLATVTQEKSRMEASY------LADKKKMKQDLEDASNKAEEE 207
V +L QL+ + +L L + K +E L+D KK QD EE
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1400
Query: 208 RARLEGELKGLQEQIAE----------TKARLITQQHDRAQEQSDHALMLRELQK----- 252
+ R + E++ L +Q E TK RL + D + + ++ L+K
Sbjct: 1401 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1460
Query: 253 --LLQEERT---------QRQDLELRLEETREALAGRAY--AAEQMEGFELQTKQLTREV 299
LL EE+ R + E R +ET+ RA A E E E K L E+
Sbjct: 1461 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1520
Query: 300 E----------------------------ELKSELQAIRDEKNQPDPRLQELQEEAARLK 331
E E+K++L+ + DE + L+ LK
Sbjct: 1521 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK 1580
Query: 332 SHFQAQLQQEMRKTALAEDQLRQQ-----SQVEEQR------VAALENQISEVSELLGTY 380
F+ LQ + QL++Q +++E++R AA + ++ +L
Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA 1640
Query: 381 EKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLK 440
+ A + + AI++L++ Q+ + L A +SR + + +E+ L+ + +L+
Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ 1700
Query: 441 RLLQVAAR-KSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRA 499
L A R + Q L+ E+L + E A++L + L+ K E
Sbjct: 1701 EDLAAAERARKQADLEKEELAE------------ELASSLSGRNALQDEKRRLE------ 1742
Query: 500 QVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARL 559
+ L +ELE Q + + ++ E+L ++ E + A+
Sbjct: 1743 --------ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE-----RSTAQK 1789
Query: 560 QQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRR 619
+ RQ+LER + R + ++E + + +A L K +LE+ +
Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849
Query: 620 SPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFF-LYAEQLARKEVEITSLRKQKHRLE 678
S D + + L +E Y EQ + + L++Q E
Sbjct: 1850 S------------LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAE 1897
Query: 679 VEVHQLQ----------DRLLEEGERHREEVAALQSHIEK 708
E ++ D E E EV AL+S + +
Sbjct: 1898 EESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1937
Score = 72.8 bits (177), Expect = 1e-12
Identities = 117/498 (23%), Positives = 215/498 (43%), Gaps = 80/498 (16%)
Query: 246 MLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSE 305
+ +++ LLQ R Q ++++ + +E ++ + A +++ E + QLT E L+ +
Sbjct: 844 LFTKVKPLLQVTR-QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 306 LQA---IRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQR 362
LQA + E + RL ++E + +A+L++E ED+ QQ Q E ++
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE-------EDR-GQQLQAERKK 954
Query: 363 VAALENQISEVSELLGTYEKAKQKDQL-------AIQKLKERILQLDLENKTLA----LA 411
+A Q+ ++ E L E A+QK QL I+KL++ IL +D +N L+ L
Sbjct: 955 MA---QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1011
Query: 412 ASSRSPLDSH---GEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSS 468
S L ++ EE + ++ LK+K E + L+V +K + + ++L L+
Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR--QELEKLKRKLEG 1069
Query: 469 EAADGEKATALYYQQ--ELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAE 526
+A+D + A Q ELK + E A L + + N K++ + +++
Sbjct: 1070 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1129
Query: 527 LKEKYISLRLSCEELEHQHQQ----------EADDWKQELARLQQL---HRQELERCQLD 573
L+E S R + + E Q + E +D A Q+L QE+ +
Sbjct: 1130 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1189
Query: 574 FRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPADT 633
+ T E ++ + R + + E +LEQ +
Sbjct: 1190 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-----------------------K 1226
Query: 634 SSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGE 693
++ D Q L+ A+ Q A++EVE +K +LE +V +LQ + +GE
Sbjct: 1227 ANLDKNKQTLEKENADLAGELRVLGQ-AKQEVE-----HKKKKLEAQVQELQSK-CSDGE 1279
Query: 694 RHREE----VAALQSHIE 707
R R E V LQ+ +E
Sbjct: 1280 RARAELNDKVHKLQNEVE 1297
Score = 39.3 bits (90), Expect = 0.014
Identities = 62/312 (19%), Positives = 123/312 (39%), Gaps = 33/312 (10%)
Query: 26 KQLLQYQARLKDVVRAYKSLLKEKEALEASIKV---LSVSHEADVGLAGVQLPGLTFPDS 82
KQL + QA++KD R + ++ + A+ K + S EAD+ +QL
Sbjct: 1652 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL----MQLQ------- 1700
Query: 83 VDDRCSTHSEDSTGTATSLDTAASLTST-KGEFGVEDDRPARGPPPPKSEEASWSESGVS 141
+D + + A L S+ G ++D++ + EE E G
Sbjct: 1701 -EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM 1759
Query: 142 SSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDAS 201
+ D + ++ QL +LAT S+ + ++E + K+ +
Sbjct: 1760 EAMSDRV---RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVK 1816
Query: 202 NKAEEERARLEGELKGLQEQI---AETKARLITQQHDRAQEQSDHALMLRELQKLLQEER 258
+K + A LE ++ L+EQ+ A K + ++ + L + + +K+ ++ +
Sbjct: 1817 SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYK 1876
Query: 259 TQ-----------RQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQ 307
Q ++ LE EE++ A R +++ + + REV LKS+L+
Sbjct: 1877 EQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Query: 308 AIRDEKNQPDPR 319
+ P R
Sbjct: 1937 RGNETSFVPSRR 1948
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 88.6 bits (218), Expect = 2e-17
Identities = 96/393 (24%), Positives = 174/393 (44%), Gaps = 41/393 (10%)
Query: 154 VDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEG 213
++ ++ ++KTQL L L K R+E + A K + ++DL+ + EE+R +L+
Sbjct: 1544 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1603
Query: 214 ELKGLQEQIA-ETKARLITQQHDRAQE--------QSDHALMLR-ELQKLLQEERTQRQD 263
+L + ++ E K R + + E Q+D A+ R E K L++ + Q +D
Sbjct: 1604 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1663
Query: 264 LELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQEL 323
+ LE+ R A R + E + K L ++ +L+ +L A + Q D +EL
Sbjct: 1664 FQRELEDAR---ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720
Query: 324 QEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEE-------QRVAALENQISEVSEL 376
EE A S A LQ E R+ QL ++ + E+ RV Q ++S
Sbjct: 1721 AEELASSLSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1779
Query: 377 LGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKM 436
L T QK++ A Q+L+ + +L +K + + +S S + L+ K+
Sbjct: 1780 LATERSTAQKNESARQQLERQ--NKELRSKLHEMEGAVKSKFKS-------TIAALEAKI 1830
Query: 437 EKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQE-------LKQLK 489
+L+ ++ AR+ Q K D ++ + E+ A Y+++ +KQLK
Sbjct: 1831 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1890
Query: 490 EEFERYKMRAQVVLKSKNTKDGNLGKELEAAQE 522
+ E + +Q + N L +EL+ A E
Sbjct: 1891 RQLEEAEEESQRI----NANRRKLQRELDEATE 1919
Score = 84.7 bits (208), Expect = 3e-16
Identities = 147/700 (21%), Positives = 285/700 (40%), Gaps = 128/700 (18%)
Query: 153 EVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERA--- 209
E+ RL K +L + + +E+ A++KKM Q + D + EEE A
Sbjct: 915 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ 974
Query: 210 ----------------------------RLEGELKGLQEQIAETKARLITQQHDRAQE-- 239
+L E K L+E+I++ L ++ ++A+
Sbjct: 975 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL-AEEEEKAKNLT 1033
Query: 240 --QSDHALMLRELQKLLQEERTQRQDLE-------------------------------- 265
++ H M+ EL+ L++E RQ+LE
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1093
Query: 266 LRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQE 325
+ EE + ALA Q + ++L + +L+ +L + R +N+ + + ++L E
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153
Query: 326 EAARLKSHFQAQL-----QQEMR----------KTALAEDQLRQQSQVEEQRVAALENQI 370
E LK+ + L QQE+R K AL E+ ++QV+E R + +
Sbjct: 1154 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ-AV 1212
Query: 371 SEVSELLGTYEKAK---QKDQLAIQK-----------LKERILQLDLENKTLALAASSRS 416
E++E L +++AK K++ ++K L + +++ + K L
Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 417 PLDSHGEESSLDVN----VLKDKMEKLKRLLQVAARKS-QVTLDVEKLCDLEIMPSSEAA 471
S GE + ++N L++++E + +L A K+ ++ DV L ++ + E
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS-QLQDTQELL 1331
Query: 472 DGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKY 531
E L +L+QL+EE + + +++K NL + + QL++ K+K
Sbjct: 1332 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ----NLERHISTLNIQLSDSKKKL 1387
Query: 532 ISLRLSCEELEH---QHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHKQ 588
+ E LE + Q+E ++ Q+ + +LE+ + + L +L Q
Sbjct: 1388 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-DKLEKTKNRLQQELDDLVVDLDNQ 1446
Query: 589 RDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAA 648
R + ++ L +K + +QL +A + + + D A+ + + T+AL LA A
Sbjct: 1447 R-QLVSNLEKKQRKFDQL--LAEEKNISSKYA-----DERDRAEAEAREKETKALSLARA 1498
Query: 649 NEPTFFLYAEQLARK----EVEITSLRKQKHRLEVEVHQLQ--DRLLE-EGERHREEVAA 701
E E+L R + E+ L K + VH+L+ R LE + E + ++
Sbjct: 1499 LEEALEA-KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1557
Query: 702 LQSHIEKNIRDQSREGANLEYLKNIIYRFLTLPDSLGRQQ 741
L+ ++ + R N++ LK R L D ++
Sbjct: 1558 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597
Score = 80.9 bits (198), Expect = 4e-15
Identities = 136/591 (23%), Positives = 265/591 (44%), Gaps = 108/591 (18%)
Query: 156 KRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGEL 215
+R + + +L L + +T+EK+ ++ A+ + + AEE R RL +
Sbjct: 873 ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE--------AEEMRVRLAAKK 924
Query: 216 KGLQEQIAETKARLITQQHDRAQ----EQSDHALMLRELQKLLQEERTQRQDLELRLEET 271
+ L+E + E +ARL ++ DR Q E+ A + +L++ L+EE RQ L+L + T
Sbjct: 925 QELEEILHEMEARL-EEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE-KVT 982
Query: 272 REALAGRAYAAEQMEGFELQTKQLTRE---VEELKSELQAIRDEKNQPDPRLQELQEEAA 328
EA + +++ + Q +L++E +EE S+L E+ + L +L+ +
Sbjct: 983 AEAKIKK--LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040
Query: 329 RLKSHFQAQLQQEMRKTALAED---QLRQQSQVEEQRVAALENQISEVSELLGTYEK--- 382
+ S + +L++E + E +L + +++A L+ QI+E+ L E+
Sbjct: 1041 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ 1100
Query: 383 ---AKQKDQL-----AIQKLKE-----RILQLDLENKTLALAASSRSPLDSHGEESSLDV 429
A+ D++ A++K++E LQ DL+++ A + + D GEE
Sbjct: 1101 AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL-GEELEALK 1159
Query: 430 NVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLK 489
L+D ++ ++ A++ Q ++K D E S EA E + Q +++L
Sbjct: 1160 TELEDTLDSTATQQELRAKREQEVTVLKKALDEETR-SHEAQVQEMRQK--HAQAVEELT 1216
Query: 490 EEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEA 549
E+ E++K RA+ NL K + +++ A+L + L + +E+EH+
Sbjct: 1217 EQLEQFK-RAK----------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK---- 1261
Query: 550 DDWKQELARLQQLHRQ--ELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLR 607
K+ A++Q+L + + ER + + D+ KL+ E+ + +L E + +
Sbjct: 1262 ---KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV----ESVTGMLNE-----AEGK 1309
Query: 608 SVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEI 667
++ LA D A SS TQ L ++ R+++ +
Sbjct: 1310 AIKLAK---------------DVASLSSQLQDTQEL-------------LQEETRQKLNV 1341
Query: 668 TSLRKQKHRLEVEVHQLQDRLLEEG------ERHREEVAALQSHIEKNIRD 712
++ +Q LE E + LQD+L EE ERH + S +K ++D
Sbjct: 1342 STKLRQ---LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389
Score = 78.6 bits (192), Expect = 2e-14
Identities = 129/632 (20%), Positives = 267/632 (42%), Gaps = 82/632 (12%)
Query: 14 KKDLLETIETQKKQLLQYQARLKDVVRAYKSLLKEKEALEASIKVLSVSHEADVGLAGVQ 73
K +L +T+++ Q R ++V K+L +E + EA ++ + H V Q
Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218
Query: 74 LPGLTFPDS-VDDRCSTHSEDSTGTATSLDTAASLTSTKGEFGVEDDRPARGPPPPKSEE 132
L + +D T +++ A GE V K E
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLA-------------GELRVLGQAKQEVEHKKKKLE 1265
Query: 133 ASWSESGVSSSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKK 192
A E + S DG A E++ ++H+L+ ++ ++T L + E + K
Sbjct: 1266 AQVQE--LQSKCSDGERARAELNDKVHKLQNEVESVTGML-------NEAEGKAI----K 1312
Query: 193 MKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRE-LQ 251
+ +D+ S++ ++ + L+ E + Q+ TK R + ++ + Q+Q D + ++ L+
Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETR--QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370
Query: 252 KLLQEERTQRQDLELRLEE---TREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQA 308
+ + Q D + +L++ T EAL E + F+ + + LT++ EE +
Sbjct: 1371 RHISTLNIQLSDSKKKLQDFASTVEAL------EEGKKRFQKEIENLTQQYEEKAAAYDK 1424
Query: 309 IRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRK------------TALAEDQLRQQS 356
+ KN+ L +L + + + L+++ RK + A+++ R ++
Sbjct: 1425 LEKTKNRLQQELDDLVVDLDN-QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483
Query: 357 QVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRS 416
+ E+ AL + + E L E+ ++ +++ ++++ + D K + S+
Sbjct: 1484 EAREKETKAL-SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542
Query: 417 PLDSHGEESSLDVNVLKDKME-----KLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAA 471
L++ EE + L+D+++ KL+ + + A K Q D++ + +
Sbjct: 1543 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQ---------ARDEQ 1593
Query: 472 DGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKY 531
+ EK L Q++L + + E E + + + +K +G+L K+LE + + +E+
Sbjct: 1594 NEEKRRQL--QRQLHEYETELEDERKQRALAAAAKKKLEGDL-KDLELQADSAIKGREEA 1650
Query: 532 ISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHK-QRD 590
I + Q+E +D + R E+ + + LE +L + Q D
Sbjct: 1651 IKQLRKLQAQMKDFQRELED--------ARASRDEIFATAKENEKKAKSLEADLMQLQED 1702
Query: 591 RALAVLTEK--DLELEQLRSVALASGLPGRRS 620
A A K DLE E+L + LAS L GR +
Sbjct: 1703 LAAAERARKQADLEKEEL-AEELASSLSGRNA 1733
Score = 75.9 bits (185), Expect = 1e-13
Identities = 131/638 (20%), Positives = 234/638 (36%), Gaps = 128/638 (20%)
Query: 154 VDKRLHQLKTQLATLTSSLATVTQEKSRMEASY------LADKKKMKQDLEDASNKAEEE 207
V +L QL+ + +L L + K +E L+D KK QD EE
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1400
Query: 208 RARLEGELKGLQEQIAE----------TKARLITQQHDRAQEQSDHALMLRELQK----- 252
+ R + E++ L +Q E TK RL + D + + ++ L+K
Sbjct: 1401 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1460
Query: 253 --LLQEERT---------QRQDLELRLEETREALAGRAY--AAEQMEGFELQTKQLTREV 299
LL EE+ R + E R +ET+ RA A E E E K L E+
Sbjct: 1461 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1520
Query: 300 E----------------------------ELKSELQAIRDEKNQPDPRLQELQEEAARLK 331
E E+K++L+ + DE + L+ LK
Sbjct: 1521 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK 1580
Query: 332 SHFQAQLQQEMRKTALAEDQLRQQ-----SQVEEQR------VAALENQISEVSELLGTY 380
F+ LQ + QL++Q +++E++R AA + ++ +L
Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA 1640
Query: 381 EKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLK 440
+ A + + AI++L++ Q+ + L A +SR + + +E+ L+ + +L+
Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ 1700
Query: 441 RLLQVAAR-KSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRA 499
L A R + Q L+ E+L + E A++L + L+ K E
Sbjct: 1701 EDLAAAERARKQADLEKEELAE------------ELASSLSGRNALQDEKRRLE------ 1742
Query: 500 QVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARL 559
+ L +ELE Q + + ++ E+L ++ E + A+
Sbjct: 1743 --------ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE-----RSTAQK 1789
Query: 560 QQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRR 619
+ RQ+LER + R + ++E + + +A L K +LE+ +
Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849
Query: 620 SPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFF-LYAEQLARKEVEITSLRKQKHRLE 678
S D + + L +E Y EQ + + L++Q E
Sbjct: 1850 S------------LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAE 1897
Query: 679 VEVHQLQ----------DRLLEEGERHREEVAALQSHI 706
E ++ D E E EV AL+S +
Sbjct: 1898 EESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935
Score = 72.8 bits (177), Expect = 1e-12
Identities = 117/498 (23%), Positives = 215/498 (43%), Gaps = 80/498 (16%)
Query: 246 MLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSE 305
+ +++ LLQ R Q ++++ + +E ++ + A +++ E + QLT E L+ +
Sbjct: 844 LFTKVKPLLQVTR-QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 306 LQA---IRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQR 362
LQA + E + RL ++E + +A+L++E ED+ QQ Q E ++
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE-------EDR-GQQLQAERKK 954
Query: 363 VAALENQISEVSELLGTYEKAKQKDQL-------AIQKLKERILQLDLENKTLA----LA 411
+A Q+ ++ E L E A+QK QL I+KL++ IL +D +N L+ L
Sbjct: 955 MA---QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1011
Query: 412 ASSRSPLDSH---GEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSS 468
S L ++ EE + ++ LK+K E + L+V +K + + ++L L+
Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR--QELEKLKRKLEG 1069
Query: 469 EAADGEKATALYYQQ--ELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAE 526
+A+D + A Q ELK + E A L + + N K++ + +++
Sbjct: 1070 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1129
Query: 527 LKEKYISLRLSCEELEHQHQQ----------EADDWKQELARLQQL---HRQELERCQLD 573
L+E S R + + E Q + E +D A Q+L QE+ +
Sbjct: 1130 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1189
Query: 574 FRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPADT 633
+ T E ++ + R + + E +LEQ +
Sbjct: 1190 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-----------------------K 1226
Query: 634 SSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGE 693
++ D Q L+ A+ Q A++EVE +K +LE +V +LQ + +GE
Sbjct: 1227 ANLDKNKQTLEKENADLAGELRVLGQ-AKQEVE-----HKKKKLEAQVQELQSK-CSDGE 1279
Query: 694 RHREE----VAALQSHIE 707
R R E V LQ+ +E
Sbjct: 1280 RARAELNDKVHKLQNEVE 1297
Score = 38.9 bits (89), Expect = 0.018
Identities = 60/300 (20%), Positives = 120/300 (40%), Gaps = 33/300 (11%)
Query: 26 KQLLQYQARLKDVVRAYKSLLKEKEALEASIKV---LSVSHEADVGLAGVQLPGLTFPDS 82
KQL + QA++KD R + ++ + A+ K + S EAD+ +QL
Sbjct: 1652 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL----MQLQ------- 1700
Query: 83 VDDRCSTHSEDSTGTATSLDTAASLTST-KGEFGVEDDRPARGPPPPKSEEASWSESGVS 141
+D + + A L S+ G ++D++ + EE E G
Sbjct: 1701 -EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM 1759
Query: 142 SSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDAS 201
+ D + ++ QL +LAT S+ + ++E + K+ +
Sbjct: 1760 EAMSDRV---RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVK 1816
Query: 202 NKAEEERARLEGELKGLQEQI---AETKARLITQQHDRAQEQSDHALMLRELQKLLQEER 258
+K + A LE ++ L+EQ+ A K + ++ + L + + +K+ ++ +
Sbjct: 1817 SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYK 1876
Query: 259 TQ-----------RQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQ 307
Q ++ LE EE++ A R +++ + + REV LKS+L+
Sbjct: 1877 EQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.126 0.333
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,883,547
Number of Sequences: 37866
Number of extensions: 1326972
Number of successful extensions: 22680
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 437
Number of HSP's successfully gapped in prelim test: 1259
Number of HSP's that attempted gapping in prelim test: 9147
Number of HSP's gapped (non-prelim): 6692
length of query: 775
length of database: 18,247,518
effective HSP length: 110
effective length of query: 665
effective length of database: 14,082,258
effective search space: 9364701570
effective search space used: 9364701570
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.