Search of human proteins with 222080049

Search of human proteins with 222080049

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo
sapiens]
         (481 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo s...   949   0.0  
gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo sap...   360   2e-99
gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo sa...   358   6e-99
gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]         173   3e-43
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa...   164   2e-40
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]   160   2e-39
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]   160   2e-39
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]    160   2e-39
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap...   160   2e-39
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa...   160   2e-39
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap...   160   2e-39
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap...   160   3e-39
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]             159   7e-39
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]                157   2e-38
gi|32483397 dopamine receptor D4 [Homo sapiens]                       156   5e-38
gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]             154   2e-37
gi|4503383 dopamine receptor D1 [Homo sapiens]                        147   2e-35
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]      145   1e-34
gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi...   143   4e-34
gi|4557265 beta-1-adrenergic receptor [Homo sapiens]                  141   1e-33
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]                140   2e-33
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]               139   4e-33
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]    139   7e-33
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]    139   7e-33
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]    139   7e-33
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]    139   7e-33
gi|4503391 dopamine receptor D5 [Homo sapiens]                        132   5e-31
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]         132   7e-31
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]         132   7e-31
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]         132   7e-31

>gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo
           sapiens]
          Length = 481

 Score =  949 bits (2454), Expect = 0.0
 Identities = 481/481 (100%), Positives = 481/481 (100%)

Query: 1   MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALL 60
           MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALL
Sbjct: 1   MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALL 60

Query: 61  ILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAM 120
           ILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAM
Sbjct: 61  ILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAM 120

Query: 121 WPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVW 180
           WPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVW
Sbjct: 121 WPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVW 180

Query: 181 LISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLT 240
           LISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLT
Sbjct: 181 LISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLT 240

Query: 241 IHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDET 300
           IHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDET
Sbjct: 241 IHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDET 300

Query: 301 LMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQM 360
           LMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQM
Sbjct: 301 LMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQM 360

Query: 361 LLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNP 420
           LLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNP
Sbjct: 361 LLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNP 420

Query: 421 MAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSY 480
           MAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSY
Sbjct: 421 MAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSY 480

Query: 481 V 481
           V
Sbjct: 481 V 481


>gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo
           sapiens]
          Length = 458

 Score =  360 bits (923), Expect = 2e-99
 Identities = 185/353 (52%), Positives = 250/353 (70%), Gaps = 19/353 (5%)

Query: 55  HWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLT 114
           +W AL I+++II TIGGN LVI+AVS+EKKL  ATNYFLMSLA+AD+LVGL VMP++LL 
Sbjct: 54  NWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLA 113

Query: 115 IMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFI 174
           I+++ +WPLP  LCP W+ LDVLFSTASIMHLCAIS+DRY+AI+ PI+ +++NSR  A +
Sbjct: 114 ILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIM 173

Query: 175 KITVVWLISIGIAIPVPIKGI-ETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIM 233
           KI +VW ISIG+++P+P+ G+ + +    NN TCVL      +F+L GS  AFF PL IM
Sbjct: 174 KIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDP---NFVLIGSFVAFFIPLTIM 230

Query: 234 IVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKAL 293
           ++TY LTI+ L+++A ++ +   +    L++      D   C             ++ A 
Sbjct: 231 VITYCLTIYVLRRQALMLLHGHTEEPPGLSL------DFLKCCKRN-----TAEEENSAN 279

Query: 294 PNSGDETLMRRTSTIGKK--SVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCD 351
           PN  D+   RR     +   ++Q I+NE++ASKVLGIVFF+FL+MWCPFFITNI  VLC+
Sbjct: 280 PNQ-DQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCE 338

Query: 352 -SCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATK 403
            SCNQ  ++ LL +FVWIGYV SG+NPLVYTLFNK +R AF  Y+ CNY+  K
Sbjct: 339 KSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEK 391


>gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo
           sapiens]
          Length = 471

 Score =  358 bits (919), Expect = 6e-99
 Identities = 186/350 (53%), Positives = 245/350 (70%), Gaps = 22/350 (6%)

Query: 55  HWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLT 114
           +W+ALL  +VII TI GN LVI+AVSLEKKLQ ATNYFLMSLA+AD+L+G  VMP+++LT
Sbjct: 75  NWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLT 134

Query: 115 IMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFI 174
           I++   WPLP  LC  W++LDVLFSTASIMHLCAIS+DRY+AI+ PI  +++NSR  AF+
Sbjct: 135 ILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFL 194

Query: 175 KITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMI 234
           KI  VW IS+GI++P+P+ G++ D       +C+L  +   +F+L GS  +FF PL IM+
Sbjct: 195 KIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADD---NFVLIGSFVSFFIPLTIMV 251

Query: 235 VTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALP 294
           +TYFLTI +LQK+A L  +    R    + S + Q       S EK+      R+     
Sbjct: 252 ITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSS----LSSEKLFQRSIHREP---- 303

Query: 295 NSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLC-DSC 353
                      S  G++++Q+ISNEQ+A KVLGIVFFLF++MWCPFFITNI  V+C +SC
Sbjct: 304 ----------GSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESC 353

Query: 354 NQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATK 403
           N+  +  LL +FVWIGY+SS VNPLVYTLFNKT+R AF RYI C Y+  K
Sbjct: 354 NEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENK 403


>gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
          Length = 414

 Score =  173 bits (439), Expect = 3e-43
 Identities = 120/397 (30%), Positives = 200/397 (50%), Gaps = 72/397 (18%)

Query: 55  HWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMP-IALL 113
           ++A LL L++ +  + GN LV +AVS EK LQ  TNY ++SLAVADLLV   VMP +  L
Sbjct: 36  YYATLLTLLIAV-IVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYL 94

Query: 114 TIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQAN-QYNSRATA 172
            ++ E  W    + C  ++ LDV+  TASI++LCAIS+DRY A+  P+  N +Y+S+   
Sbjct: 95  EVVGE--WKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRV 152

Query: 173 FIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAI 232
            + I++VW++S  I+ P+        ++N +   C++       F+++ S+ +F+ P  +
Sbjct: 153 TVMISIVWVLSFTISCPLLF-----GLNNADQNECIIANPA---FVVYSSIVSFYVPFIV 204

Query: 233 MIVTYFLTIHALQKKAYLVKNK---------------------------------PPQRL 259
            ++ Y      L+++   V  K                                 PP+R 
Sbjct: 205 TLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPERT 264

Query: 260 TWLTVSTVFQRDETP-------CSSPEKVAM--LDGSRKD----------KALPNSGDET 300
            +  +     +   P        S+P+  A    +G  KD          + +PN    T
Sbjct: 265 RYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRT 324

Query: 301 LMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQM 360
            ++   T+ ++ +     E++A+++L IV  +F++ W PFFIT+I  + CD CN     +
Sbjct: 325 SLK---TMSRRKLSQ-QKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD-CN--IPPV 377

Query: 361 LLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITC 397
           L   F W+GYV+S VNP++YT FN  FR AF + + C
Sbjct: 378 LYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 414


>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
           sapiens]
          Length = 422

 Score =  164 bits (415), Expect = 2e-40
 Identities = 119/386 (30%), Positives = 186/386 (48%), Gaps = 50/386 (12%)

Query: 58  ALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMF 117
           +LL+  +I   + GN  V+ A++LE+ LQ   NY + SLAV DL+V + V+P+A L  + 
Sbjct: 40  SLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVL 99

Query: 118 EAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKIT 177
              W L  V C  ++ LDVL  T+SI+HLCAI++DRY AI  PI      +   A   I+
Sbjct: 100 NK-WTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALIS 158

Query: 178 VVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTY 237
           + WLI   I+IP P+ G  T  D  +   C ++K+    + ++ +  AF+ PL +M+V Y
Sbjct: 159 LTWLIGFLISIP-PMLGWRTPEDRSDPDACTISKDH--GYTIYSTFGAFYIPLLLMLVLY 215

Query: 238 FLTIHA----LQKKAYLVKN-------------KPPQRLTWLTVS--------------- 265
                A    ++K    V+              +P + +   + S               
Sbjct: 216 GRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGAL 275

Query: 266 ----TVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGK-------KSVQ 314
                V Q D+       +V  +  S++   LP+    T     S   K       K   
Sbjct: 276 CANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKM 335

Query: 315 TISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCD-SCNQTTLQMLLEIFVWIGYVSS 373
            ++ E++  K LGI+   F+L W PFFI  + L  C+ SC+  TL  L  I  W+GY +S
Sbjct: 336 ALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTL--LGAIINWLGYSNS 393

Query: 374 GVNPLVYTLFNKTFRDAFGRYITCNY 399
            +NP++Y  FNK F++AF + I C +
Sbjct: 394 LLNPVIYAYFNKDFQNAFKKIIKCKF 419


>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
          Length = 432

 Score =  160 bits (406), Expect = 2e-39
 Identities = 103/343 (30%), Positives = 177/343 (51%), Gaps = 27/343 (7%)

Query: 60  LILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEA 119
           ++ ++ + TI GN LV+++V   KKL+  +NY ++SLA+ADL V + VMP   +T +   
Sbjct: 87  ILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGG 146

Query: 120 MWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVV 179
            W      C  ++ +DV+  TASIM LC IS+DRY+ I +P+      +       I  V
Sbjct: 147 KWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSV 206

Query: 180 WLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFL 239
           WL+S  I +P P+ G   +V++     C+++++ FG + ++ +  AF+ P+++M+  Y+ 
Sbjct: 207 WLLSASITLP-PLFGWAQNVNDDK--VCLISQD-FG-YTIYSTAVAFYIPMSVMLFMYYQ 261

Query: 240 TIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDE 299
              A +K A   K+K P           F R E     P+ V  L+G  K   L    +E
Sbjct: 262 IYKAARKSA--AKHKFPG----------FPRVE-----PDSVIALNGIVK---LQKEVEE 301

Query: 300 TL-MRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTL 358
              + R     +K++     EQ+A+  LGI+   F + W PFF+ +         + + +
Sbjct: 302 CANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCI 361

Query: 359 QMLLE-IFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYR 400
            + +E  F+W+GY +S +NP +Y  FN+  R  +   + C YR
Sbjct: 362 PLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYR 404


>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
          Length = 479

 Score =  160 bits (406), Expect = 2e-39
 Identities = 103/343 (30%), Positives = 177/343 (51%), Gaps = 27/343 (7%)

Query: 60  LILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEA 119
           ++ ++ + TI GN LV+++V   KKL+  +NY ++SLA+ADL V + VMP   +T +   
Sbjct: 87  ILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGG 146

Query: 120 MWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVV 179
            W      C  ++ +DV+  TASIM LC IS+DRY+ I +P+      +       I  V
Sbjct: 147 KWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSV 206

Query: 180 WLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFL 239
           WL+S  I +P P+ G   +V++     C+++++ FG + ++ +  AF+ P+++M+  Y+ 
Sbjct: 207 WLLSASITLP-PLFGWAQNVNDDK--VCLISQD-FG-YTIYSTAVAFYIPMSVMLFMYYQ 261

Query: 240 TIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDE 299
              A +K A   K+K P           F R E     P+ V  L+G  K   L    +E
Sbjct: 262 IYKAARKSA--AKHKFPG----------FPRVE-----PDSVIALNGIVK---LQKEVEE 301

Query: 300 TL-MRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTL 358
              + R     +K++     EQ+A+  LGI+   F + W PFF+ +         + + +
Sbjct: 302 CANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCI 361

Query: 359 QMLLE-IFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYR 400
            + +E  F+W+GY +S +NP +Y  FN+  R  +   + C YR
Sbjct: 362 PLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYR 404


>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
          Length = 445

 Score =  160 bits (406), Expect = 2e-39
 Identities = 103/343 (30%), Positives = 177/343 (51%), Gaps = 27/343 (7%)

Query: 60  LILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEA 119
           ++ ++ + TI GN LV+++V   KKL+  +NY ++SLA+ADL V + VMP   +T +   
Sbjct: 87  ILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGG 146

Query: 120 MWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVV 179
            W      C  ++ +DV+  TASIM LC IS+DRY+ I +P+      +       I  V
Sbjct: 147 KWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSV 206

Query: 180 WLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFL 239
           WL+S  I +P P+ G   +V++     C+++++ FG + ++ +  AF+ P+++M+  Y+ 
Sbjct: 207 WLLSASITLP-PLFGWAQNVNDDK--VCLISQD-FG-YTIYSTAVAFYIPMSVMLFMYYQ 261

Query: 240 TIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDE 299
              A +K A   K+K P           F R E     P+ V  L+G  K   L    +E
Sbjct: 262 IYKAARKSA--AKHKFPG----------FPRVE-----PDSVIALNGIVK---LQKEVEE 301

Query: 300 TL-MRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTL 358
              + R     +K++     EQ+A+  LGI+   F + W PFF+ +         + + +
Sbjct: 302 CANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCI 361

Query: 359 QMLLE-IFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYR 400
            + +E  F+W+GY +S +NP +Y  FN+  R  +   + C YR
Sbjct: 362 PLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYR 404


>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
           sapiens]
          Length = 365

 Score =  160 bits (406), Expect = 2e-39
 Identities = 106/347 (30%), Positives = 175/347 (50%), Gaps = 18/347 (5%)

Query: 59  LLILMVIIPTIGG--NTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIM 116
           + + +V+I T+    N  VI+A+   KKL    NY + SLAV DLLV + VMP++++ I+
Sbjct: 25  ICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIV 84

Query: 117 FEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKI 176
            +  W L   LC  WL +D+   T SI+HLC I++DRY AI   I+  +  +   A + I
Sbjct: 85  MDR-WKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAALMI 143

Query: 177 TVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVT 236
             VW ISI I++P P+        +P    C +  +    + ++ +L AF+ PL ++++ 
Sbjct: 144 LTVWTISIFISMP-PLFWRSHRRLSPPPSQCTIQHDHV-IYTIYSTLGAFYIPLTLILIL 201

Query: 237 YFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNS 296
           Y+   HA   K+   K    + L+    ST  Q     C   +   + D S  D      
Sbjct: 202 YYRIYHA--AKSLYQKRGSSRHLS--NRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEFE 257

Query: 297 GDETLMR------RTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLC 350
                +R           G++   + + E++A+++LG++   F+L W PFFI  + + L 
Sbjct: 258 KFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFILSWLPFFIKELIVGL- 316

Query: 351 DSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITC 397
                T    + +   W+GYV+S +NPL+YT FN+ F+ AF + I C
Sbjct: 317 --SIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRC 361


>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
           sapiens]
          Length = 366

 Score =  160 bits (405), Expect = 2e-39
 Identities = 101/336 (30%), Positives = 180/336 (53%), Gaps = 22/336 (6%)

Query: 72  NTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAW 131
           N+LVI A+ + +KL +  NY + SLAV D LV + VMP +++ I+ E+ W +  V+C  W
Sbjct: 41  NSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRES-WIMGQVVCDIW 99

Query: 132 LFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVP 191
           L +D+   T SI+HL AI++DRY AI   ++  +  +   A I IT+VW+IS+ I++P P
Sbjct: 100 LSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMP-P 158

Query: 192 I----KGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKK 247
           +    +G   D +      C++  +      ++ +  AF+ PLA++++ Y+  I+   K 
Sbjct: 159 LFWRHQGTSRDDE------CIIKHDHIVS-TIYSTFGAFYIPLALILILYY-KIYRAAKT 210

Query: 248 AYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMR--RT 305
            Y  +         +    + +  E    S     +L+ S  D +       + +R  R+
Sbjct: 211 LYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRS 270

Query: 306 STIGKKS--VQTIS--NEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQML 361
               +KS   Q IS   E++A+  LG++   F++ W PFF+  + + +CD C  +  + +
Sbjct: 271 EFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKIS--EEM 328

Query: 362 LEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITC 397
                W+GY++S +NPL+YT+FN+ F+ AF + + C
Sbjct: 329 SNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRC 364


>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
           sapiens]
          Length = 390

 Score =  160 bits (405), Expect = 2e-39
 Identities = 105/362 (29%), Positives = 187/362 (51%), Gaps = 23/362 (6%)

Query: 44  KQIVEEQGNKLHWAALLILMVIIPTIG---GNTLVILAVSLEKKLQYATNYFLMSLAVAD 100
           K  + +    L W  LL++++ + T+     N  VI  V   +KL    NY + SLAV D
Sbjct: 36  KDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTD 95

Query: 101 LLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKP 160
           LLV + VMPI+ +  +    W L  V+C  WL  D+   TASI+HLC I++DRY AI   
Sbjct: 96  LLVSILVMPISTMYTV-TGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDA 154

Query: 161 IQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLF 220
           ++ +   +   A + I +VW+ SI I++P P    +   +   +  CV+  +    + ++
Sbjct: 155 VEYSAKRTPKRAAVMIALVWVFSISISLP-PFFWRQAKAEEEVS-ECVVNTDHI-LYTVY 211

Query: 221 GSLAAFFTPLAIMIVTY-FLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPE 279
            ++ AF+ P  ++I  Y  + + A  +      N+  +RLT   + T     ++P S+  
Sbjct: 212 STVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLIT-----DSPGSTSS 266

Query: 280 KVAMLDGSRKDKALPNSG-----DETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFL 334
             ++   SR       SG     ++  +R +  + +K     + E++A+K LGI+   F+
Sbjct: 267 VTSI--NSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFI 324

Query: 335 LMWCPFFITNITLVLC-DSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGR 393
           + W PFFI ++ + +C D+C       + + F W+GY++S +NP++YT+ N+ F+ AF +
Sbjct: 325 VCWLPFFIISLVMPICKDAC--WFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHK 382

Query: 394 YI 395
            I
Sbjct: 383 LI 384


>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
           sapiens]
          Length = 377

 Score =  160 bits (404), Expect = 3e-39
 Identities = 95/339 (28%), Positives = 172/339 (50%), Gaps = 10/339 (2%)

Query: 58  ALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMF 117
           A+++ ++ + T+  N  V+  + L +KL    NY + SLA  DLLV + VMPI++   + 
Sbjct: 42  AVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTIT 101

Query: 118 EAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKIT 177
              W    +LC  WL  D+   TASI+HLC I++DRY AI   ++ ++  +   A   I 
Sbjct: 102 HT-WNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIA 160

Query: 178 VVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTY 237
           +VW ISI I+IP P+   +       +   V T +    + ++ +  AF+ P  ++I+ Y
Sbjct: 161 IVWAISICISIP-PLFWRQAKAQEEMSDCLVNTSQI--SYTIYSTCGAFYIPSVLLIILY 217

Query: 238 FLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSG 297
                A + +   + N P       T + +              ++ +G       P   
Sbjct: 218 GRIYRAARNR---ILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFF 274

Query: 298 DETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLC-DSCNQT 356
           +   ++   +  ++   + + E++A+K+LGI+   F++ W PFF+ ++ L +C DSC   
Sbjct: 275 NHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSC--W 332

Query: 357 TLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYI 395
               L + F W+GY++S +NP++YT+FN+ FR AF + +
Sbjct: 333 IHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371


>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
          Length = 367

 Score =  159 bits (401), Expect = 7e-39
 Identities = 108/352 (30%), Positives = 186/352 (52%), Gaps = 29/352 (8%)

Query: 58  ALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMF 117
           AL    +I+  + GN LV +AV  E+ LQ  TNY ++SLAVADLLV   VMP  +   + 
Sbjct: 33  ALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVT 92

Query: 118 EAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQ----ANQYNSRATAF 173
             +W    + C  ++ LDV+  TASI++LCAIS+DRY A+  P+       Q + R  A 
Sbjct: 93  GGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVA- 151

Query: 174 IKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIM 233
           + IT VW+++  ++ P+ + G  T  D      C ++     DF+++ S+ +F+ P  + 
Sbjct: 152 LMITAVWVLAFAVSCPL-LFGFNTTGD---PTVCSISNP---DFVIYSSVVSFYLPFGVT 204

Query: 234 IVTY---FLTIHALQKKAYLVKNKPPQRLTWLTVSTVF-QRDETPCSSPEKVAMLDGSRK 289
           ++ Y   ++ +   ++K  L +    Q     +V   F Q+  +P  +  ++       +
Sbjct: 205 VLVYARIYVVLKQRRRKRILTR----QNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQ 260

Query: 290 DKALPNSGDE----TLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNI 345
           D AL   G +     L R   T  + S+  +  E++A++++ IV   F++ W PFF+T++
Sbjct: 261 DTALGGPGFQERGGELKREEKT--RNSLMPL-REKKATQMVAIVLGAFIVCWLPFFLTHV 317

Query: 346 TLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITC 397
               C +C+ +    L     W+GYV+S +NP++YT FN  FR AF + ++C
Sbjct: 318 LNTHCQTCHVS--PELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367


>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
          Length = 520

 Score =  157 bits (397), Expect = 2e-38
 Identities = 113/354 (31%), Positives = 181/354 (51%), Gaps = 25/354 (7%)

Query: 59  LLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPI-ALLTIMF 117
           L++   I+  I GN LVIL+V+  + L+  TNYF+++LA+ADLL+   V+P  A L ++ 
Sbjct: 50  LVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVL- 108

Query: 118 EAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKIT 177
              W L  + C  W  +DVL  TASI+ LCAIS+DRYI ++  +Q     +R  A + + 
Sbjct: 109 -GYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALL 167

Query: 178 VVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTY 237
            VW++S  I+I  P+ G +    N +   C +T+E F  + LF SL +F+ PLA+++V Y
Sbjct: 168 SVWVLSTVISIG-PLLGWKEPAPNDDK-ECGVTEEPF--YALFSSLGSFYIPLAVILVMY 223

Query: 238 FLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSG 297
                    + Y+V  +  + L    +  +    E       K    D     KA  ++ 
Sbjct: 224 C--------RVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHN- 274

Query: 298 DETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTT 357
                   S+I  K  +  S E++A+K LGIV  +F+L W PFFI      L  +     
Sbjct: 275 ------PRSSIAVKLFK-FSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPP- 326

Query: 358 LQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKR 411
              + ++  W+GY +S +NP++Y   +K F+ AF R + C  R     +  R+R
Sbjct: 327 -DAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRR 379


>gi|32483397 dopamine receptor D4 [Homo sapiens]
          Length = 419

 Score =  156 bits (394), Expect = 5e-38
 Identities = 111/386 (28%), Positives = 183/386 (47%), Gaps = 60/386 (15%)

Query: 57  AALLI--LMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLT 114
           AA L+  +++I   + GN+LV ++V+ E+ LQ  TN F++SLA ADLL+ L V+P+ + +
Sbjct: 35  AAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYS 94

Query: 115 IMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFI 174
            +    W L   LC A + +DV+  TASI +LCAISVDR++A+  P++ N+        +
Sbjct: 95  EVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLL 154

Query: 175 KITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMI 234
            I   WL+S  +A PV + G+  DV   +   C L      D++++ S+ +FF P  +M+
Sbjct: 155 LIGATWLLSAAVAAPV-LCGL-NDVRGRDPAVCRLEDR---DYVVYSSVCSFFLPCPLML 209

Query: 235 VTYFLTIHALQK----KAYLVKNKPPQRLTW----LTVSTVFQRDETPCS---------- 276
           + Y+ T   LQ+    +   +  + P+R +            +  + PC           
Sbjct: 210 LLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGL 269

Query: 277 ---------------------SPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQT 315
                                 P+      G   D    N      +R  +   +   QT
Sbjct: 270 PRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQT 329

Query: 316 ISNEQRASKVLG----------IVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIF 365
               +R +K+ G          +V   FLL W PFF+ +IT  LC +C  +    L+   
Sbjct: 330 --RRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPAC--SVPPRLVSAV 385

Query: 366 VWIGYVSSGVNPLVYTLFNKTFRDAF 391
            W+GYV+S +NP++YT+FN  FR+ F
Sbjct: 386 TWLGYVNSALNPVIYTVFNAEFRNVF 411


>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
          Length = 400

 Score =  154 bits (388), Expect = 2e-37
 Identities = 108/378 (28%), Positives = 186/378 (49%), Gaps = 48/378 (12%)

Query: 58  ALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMF 117
           AL    +I+  + GN LV +AV  E+ LQ  TNY ++SLAVADLLV   VMP  +   + 
Sbjct: 33  ALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVT 92

Query: 118 EAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQ----ANQYNSRATAF 173
             +W    + C  ++ LDV+  TASI++LCAIS+DRY A+  P+       Q + R  A 
Sbjct: 93  GGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVA- 151

Query: 174 IKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIM 233
           + IT VW+++  ++ P+ + G  T  D      C ++     DF+++ S+ +F+ P  + 
Sbjct: 152 LMITAVWVLAFAVSCPL-LFGFNTTGD---PTVCSISNP---DFVIYSSVVSFYLPFGVT 204

Query: 234 IVTY---FLTIHALQKKAYLVKNK----------PPQRLTWLTVSTVFQR-----DETPC 275
           ++ Y   ++ +   ++K  L +            P Q L+        +R      +T  
Sbjct: 205 VLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTAL 264

Query: 276 SSPEKVAMLDGSRKDKALPNSGDETLMRRTS-TIGKKSVQTIS---------------NE 319
             P         ++++   NS   T+  + S  + K S   +S                E
Sbjct: 265 GGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLRE 324

Query: 320 QRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLV 379
           ++A++++ IV   F++ W PFF+T++    C +C+ +    L     W+GYV+S +NP++
Sbjct: 325 KKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVS--PELYSATTWLGYVNSALNPVI 382

Query: 380 YTLFNKTFRDAFGRYITC 397
           YT FN  FR AF + ++C
Sbjct: 383 YTTFNIEFRKAFLKILSC 400


>gi|4503383 dopamine receptor D1 [Homo sapiens]
          Length = 446

 Score =  147 bits (371), Expect = 2e-35
 Identities = 109/365 (29%), Positives = 175/365 (47%), Gaps = 45/365 (12%)

Query: 46  IVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQY-ATNYFLMSLAVADLLVG 104
           +VE   +     A  + ++I+ T+ GNTLV  AV   + L+   TN+F++SLAV+DLLV 
Sbjct: 15  VVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVA 74

Query: 105 LFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQAN 164
           + VMP   +  +    WP     C  W+  D++ STASI++LC ISVDRY AI  P +  
Sbjct: 75  VLVMPWKAVAEI-AGFWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYE 132

Query: 165 QYNSRATAFIKITVVWLISIGIA-IPVPIKGIETDVDNPNNITCVLTKERFGD------- 216
           +  +   AFI I+V W +S+ I+ IPV +   +    +P++       E   +       
Sbjct: 133 RKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSR 192

Query: 217 -FMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPC 275
            + +  S+ +F+ P+AIMIVTY         + Y +  K  +R+  L  + V  ++   C
Sbjct: 193 TYAISSSVISFYIPVAIMIVTY--------TRIYRIAQKQIRRIAALERAAVHAKN---C 241

Query: 276 SSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLL 335
            +       +G   + + P S  +   +R              E +  K L ++  +F+ 
Sbjct: 242 QTTTG----NGKPVECSQPESSFKMSFKR--------------ETKVLKTLSVIMGVFVC 283

Query: 336 MWCPFFITNITLVLCDSCNQTTL---QMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFG 392
            W PFFI N  L  C S             ++FVW G+ +S +NP++Y  FN  FR AF 
Sbjct: 284 CWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYA-FNADFRKAFS 342

Query: 393 RYITC 397
             + C
Sbjct: 343 TLLGC 347


>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
          Length = 413

 Score =  145 bits (365), Expect = 1e-34
 Identities = 108/339 (31%), Positives = 162/339 (47%), Gaps = 46/339 (13%)

Query: 59  LLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFE 118
           +++ ++++  + GN LVI A++  ++LQ  TNYF+ SLA ADL++GL V+P     I+ +
Sbjct: 38  IVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMK 97

Query: 119 AMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITV 178
            MW      C  W  +DVL  TASI  LC I+VDRY AI  P +     ++  A + I +
Sbjct: 98  -MWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILM 156

Query: 179 VWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFM------LFGSLAAFFTPLAI 232
           VW++S G+   +PI+       +   I C    E   DF       +  S+ +F+ PL I
Sbjct: 157 VWIVS-GLTSFLPIQMHWYRATHQEAINCY-ANETCCDFFTNQAYAIASSIVSFYVPLVI 214

Query: 233 MIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKA 292
           M+  Y                           S VFQ       +  ++  +D S     
Sbjct: 215 MVFVY---------------------------SRVFQE------AKRQLQKIDKSEGRFH 241

Query: 293 LPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDS 352
           + N        RT    ++S +    E +A K LGI+   F L W PFFI NI  V+ D+
Sbjct: 242 VQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDN 301

Query: 353 CNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAF 391
             +  + +LL    WIGYV+SG NPL+Y   +  FR AF
Sbjct: 302 LIRKEVYILLN---WIGYVNSGFNPLIYCR-SPDFRIAF 336


>gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
           sapiens]
          Length = 440

 Score =  143 bits (360), Expect = 4e-34
 Identities = 106/344 (30%), Positives = 164/344 (47%), Gaps = 36/344 (10%)

Query: 56  WAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTI 115
           W A  + +VI  T   N+L+I  +  +  L+  +N+FL+SL  +DL+VGL VMP A+L  
Sbjct: 28  WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNA 87

Query: 116 MFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIK 175
           ++   W L   LC  W   DV+  +ASI++LC IS+DRY+ I  P++     +   A   
Sbjct: 88  LY-GRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALAL 146

Query: 176 ITVVW-LISIGIAIPVPIKGIET-DVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIM 233
           +   W L ++   +P+ +   E      P    C L       F+L  S   FF P   +
Sbjct: 147 VLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASL--PFVLVASGLTFFLPSGAI 204

Query: 234 IVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKAL 293
             TY   + A +K+A  V +        LT     Q  ET          L   R  +  
Sbjct: 205 CFTYCRILLAARKQAVQVAS--------LTTGMASQASET----------LQVPRTPRPG 246

Query: 294 PNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSC 353
             S D    RR +T  K S + +    +AS  LGI+  +F + W PFF+ NI   +CD  
Sbjct: 247 VESADS---RRLAT--KHSRKAL----KASLTLGILLGMFFVTWLPFFVANIVQAVCDCI 297

Query: 354 NQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITC 397
           +      L ++  W+GY +S +NP++Y LF + F+ A GR++ C
Sbjct: 298 SPG----LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPC 337


>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
          Length = 477

 Score =  141 bits (355), Expect = 1e-33
 Identities = 107/359 (29%), Positives = 160/359 (44%), Gaps = 27/359 (7%)

Query: 56  WAA---LLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIAL 112
           W A   LL+ ++++  + GN LVI+A++   +LQ  TN F+MSLA ADL++GL V+P   
Sbjct: 57  WTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFG- 115

Query: 113 LTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATA 172
            TI+    W      C  W  +DVL  TASI  LC I++DRY+AI  P +     +RA A
Sbjct: 116 ATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARA 175

Query: 173 FIKITVVWLISIGIA-IPVPIKGIETDVDNPNNI-----TCVLTKERFGDFMLFGSLAAF 226
              +  VW IS  ++ +P+ +     + D           C     R   + +  S+ +F
Sbjct: 176 RGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNR--AYAIASSVVSF 233

Query: 227 FTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDG 286
           + PL IM   Y       QK+   + +   + L          R  +P  SP        
Sbjct: 234 YVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPA------RPPSPSPSP---VPAPA 284

Query: 287 SRKDKALPNSGDETLMRRTSTIGKK--SVQTISNEQRASKVLGIVFFLFLLMWCPFFITN 344
                  P +   T        GK+  S      EQ+A K LGI+  +F L W PFF+ N
Sbjct: 285 PPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLAN 344

Query: 345 ITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATK 403
           +         +     L   F W+GY +S  NP++Y   +  FR AF   + C  RA +
Sbjct: 345 VVKAF---HRELVPDRLFVFFNWLGYANSAFNPIIYCR-SPDFRKAFQGLLCCARRAAR 399


>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
          Length = 572

 Score =  140 bits (354), Expect = 2e-33
 Identities = 98/348 (28%), Positives = 172/348 (49%), Gaps = 28/348 (8%)

Query: 65  IIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLP 124
           I+  + GN LVIL+V+  + LQ  TNYF+++LAVADLL+   V+P +  T+     W   
Sbjct: 107 ILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSA-TMEVLGFWAFG 165

Query: 125 LVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISI 184
              C  W  +DVL  TASI+ LC ISVDRY+ ++  ++     +   A   + ++W++++
Sbjct: 166 RAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVAL 225

Query: 185 GIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHAL 244
            +++  P+ G +  V  P+   C +T+E    + +F S+ +F+ P+A+++V Y       
Sbjct: 226 VVSVG-PLLGWKEPVP-PDERFCGITEE--AGYAVFSSVCSFYLPMAVIVVMYC------ 275

Query: 245 QKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRR 304
             + Y+V      R T  ++    +R+    S      +L    +  A    G   +   
Sbjct: 276 --RVYVV-----ARSTTRSLEAGVKRERGKASE----VVLRIHCRGAATGADGAHGMRSA 324

Query: 305 TSTIGKKSVQT----ISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQM 360
                + S+       S E++A+K L IV  +F+L W PFF       L      +  + 
Sbjct: 325 KGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPS--EG 382

Query: 361 LLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTL 408
           + ++  W+GY +S VNPL+Y   ++ F+ AF R + C  R  +  + L
Sbjct: 383 VFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPL 430


>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
          Length = 408

 Score =  139 bits (351), Expect = 4e-33
 Identities = 101/350 (28%), Positives = 158/350 (45%), Gaps = 40/350 (11%)

Query: 57  AALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIM 116
           A  L+ + ++ T+GGN LVI+A++   +LQ  TN F+ SLA ADL++GL V+P A  T+ 
Sbjct: 40  AGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAA-TLA 98

Query: 117 FEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKI 176
               WPL    C  W  +DVL  TASI  LCA++VDRY+A+  P++     ++  A   +
Sbjct: 99  LTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAV 158

Query: 177 TVVWLISIGIAI-PVPIKGIETDVD------NPNNITCVLTKERFGDFMLFGSLAAFFTP 229
            +VW++S  ++  P+  +      D      + N   C         ++L  S  +F+ P
Sbjct: 159 VLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNM--PYVLLSSSVSFYLP 216

Query: 230 LAIMIVTYFLTIHALQKKAYLVKNK----PPQRLTWLTVSTVFQRDETPCSSPEKVAMLD 285
           L +M+  Y        ++  L++ +    PP+        ++       C+ PE V    
Sbjct: 217 LLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPAC- 275

Query: 286 GSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNI 345
           G R  + LP                        E RA   LG++   F L W PFF+ N+
Sbjct: 276 GRRPARLLP----------------------LREHRALCTLGLIMGTFTLCWLPFFLANV 313

Query: 346 TLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYI 395
              L           L     W+GY +S  NPL+Y   +  FR AF R +
Sbjct: 314 LRALGGPSLVPGPAFL--ALNWLGYANSAFNPLIYCR-SPDFRSAFRRLL 360


>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
          Length = 455

 Score =  139 bits (349), Expect = 7e-33
 Identities = 99/323 (30%), Positives = 163/323 (50%), Gaps = 30/323 (9%)

Query: 71  GNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAM--WPLPLVLC 128
           GN LVIL+V+  + L   T+Y++++LAVADLL+   V+P + +   FE +  W    V C
Sbjct: 43  GNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAI---FEVLGYWAFGRVFC 99

Query: 129 PAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAI 188
             W  +DVL  TASIM LC IS+DRYI +  P++     ++    + +  VW +S+ I+I
Sbjct: 100 NIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISI 159

Query: 189 PVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKA 248
             P+ G          I C + +E    ++LF +L +F+ PLAI++V Y         + 
Sbjct: 160 G-PLFGWRQPAPEDETI-CQINEE--PGYVLFSALGSFYLPLAIILVMYC--------RV 207

Query: 249 YLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTI 308
           Y+V  +  + L            +T  S  E+V +       K  P  G      +T T 
Sbjct: 208 YVVAKRESRGLK--------SGLKTDKSDSEQVTL---RIHRKNAPAGGSGMASAKTKTH 256

Query: 309 GKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWI 368
               +   S E++A+K LGIV   F+L W PFF+  +  +     +    + + +I  W+
Sbjct: 257 FSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFL--VMPIGSFFPDFKPSETVFKIVFWL 314

Query: 369 GYVSSGVNPLVYTLFNKTFRDAF 391
           GY++S +NP++Y   ++ F+ AF
Sbjct: 315 GYLNSCINPIIYPCSSQEFKKAF 337


>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
          Length = 466

 Score =  139 bits (349), Expect = 7e-33
 Identities = 99/323 (30%), Positives = 163/323 (50%), Gaps = 30/323 (9%)

Query: 71  GNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAM--WPLPLVLC 128
           GN LVIL+V+  + L   T+Y++++LAVADLL+   V+P + +   FE +  W    V C
Sbjct: 43  GNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAI---FEVLGYWAFGRVFC 99

Query: 129 PAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAI 188
             W  +DVL  TASIM LC IS+DRYI +  P++     ++    + +  VW +S+ I+I
Sbjct: 100 NIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISI 159

Query: 189 PVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKA 248
             P+ G          I C + +E    ++LF +L +F+ PLAI++V Y         + 
Sbjct: 160 G-PLFGWRQPAPEDETI-CQINEE--PGYVLFSALGSFYLPLAIILVMYC--------RV 207

Query: 249 YLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTI 308
           Y+V  +  + L            +T  S  E+V +       K  P  G      +T T 
Sbjct: 208 YVVAKRESRGLK--------SGLKTDKSDSEQVTL---RIHRKNAPAGGSGMASAKTKTH 256

Query: 309 GKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWI 368
               +   S E++A+K LGIV   F+L W PFF+  +  +     +    + + +I  W+
Sbjct: 257 FSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFL--VMPIGSFFPDFKPSETVFKIVFWL 314

Query: 369 GYVSSGVNPLVYTLFNKTFRDAF 391
           GY++S +NP++Y   ++ F+ AF
Sbjct: 315 GYLNSCINPIIYPCSSQEFKKAF 337


>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
          Length = 475

 Score =  139 bits (349), Expect = 7e-33
 Identities = 99/323 (30%), Positives = 163/323 (50%), Gaps = 30/323 (9%)

Query: 71  GNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAM--WPLPLVLC 128
           GN LVIL+V+  + L   T+Y++++LAVADLL+   V+P + +   FE +  W    V C
Sbjct: 43  GNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAI---FEVLGYWAFGRVFC 99

Query: 129 PAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAI 188
             W  +DVL  TASIM LC IS+DRYI +  P++     ++    + +  VW +S+ I+I
Sbjct: 100 NIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISI 159

Query: 189 PVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKA 248
             P+ G          I C + +E    ++LF +L +F+ PLAI++V Y         + 
Sbjct: 160 G-PLFGWRQPAPEDETI-CQINEE--PGYVLFSALGSFYLPLAIILVMYC--------RV 207

Query: 249 YLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTI 308
           Y+V  +  + L            +T  S  E+V +       K  P  G      +T T 
Sbjct: 208 YVVAKRESRGLK--------SGLKTDKSDSEQVTL---RIHRKNAPAGGSGMASAKTKTH 256

Query: 309 GKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWI 368
               +   S E++A+K LGIV   F+L W PFF+  +  +     +    + + +I  W+
Sbjct: 257 FSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFL--VMPIGSFFPDFKPSETVFKIVFWL 314

Query: 369 GYVSSGVNPLVYTLFNKTFRDAF 391
           GY++S +NP++Y   ++ F+ AF
Sbjct: 315 GYLNSCINPIIYPCSSQEFKKAF 337


>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
          Length = 429

 Score =  139 bits (349), Expect = 7e-33
 Identities = 99/323 (30%), Positives = 163/323 (50%), Gaps = 30/323 (9%)

Query: 71  GNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAM--WPLPLVLC 128
           GN LVIL+V+  + L   T+Y++++LAVADLL+   V+P + +   FE +  W    V C
Sbjct: 43  GNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAI---FEVLGYWAFGRVFC 99

Query: 129 PAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAI 188
             W  +DVL  TASIM LC IS+DRYI +  P++     ++    + +  VW +S+ I+I
Sbjct: 100 NIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISI 159

Query: 189 PVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKA 248
             P+ G          I C + +E    ++LF +L +F+ PLAI++V Y         + 
Sbjct: 160 G-PLFGWRQPAPEDETI-CQINEE--PGYVLFSALGSFYLPLAIILVMYC--------RV 207

Query: 249 YLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTI 308
           Y+V  +  + L            +T  S  E+V +       K  P  G      +T T 
Sbjct: 208 YVVAKRESRGLK--------SGLKTDKSDSEQVTL---RIHRKNAPAGGSGMASAKTKTH 256

Query: 309 GKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWI 368
               +   S E++A+K LGIV   F+L W PFF+  +  +     +    + + +I  W+
Sbjct: 257 FSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFL--VMPIGSFFPDFKPSETVFKIVFWL 314

Query: 369 GYVSSGVNPLVYTLFNKTFRDAF 391
           GY++S +NP++Y   ++ F+ AF
Sbjct: 315 GYLNSCINPIIYPCSSQEFKKAF 337


>gi|4503391 dopamine receptor D5 [Homo sapiens]
          Length = 477

 Score =  132 bits (333), Expect = 5e-31
 Identities = 110/418 (26%), Positives = 191/418 (45%), Gaps = 77/418 (18%)

Query: 58  ALLILMVIIPTIGGNTLVILAVSLEKKLQY-ATNYFLMSLAVADLLVGLFVMPIALLTIM 116
           A L+ ++II T+ GN LV  A+   + L+   TN F++SLAV+DL V L VMP   +  +
Sbjct: 44  ACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEV 103

Query: 117 FEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKI 176
               WP     C  W+  D++ STASI++LC ISVDRY AI +P +  +  ++  A + +
Sbjct: 104 -AGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMV 161

Query: 177 TVVWLISIGIA-IPVPIKGIETD------VDNPNNI------------------TCVLTK 211
            + W +SI I+ IPV +            +D PNN+                   C  + 
Sbjct: 162 GLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSL 221

Query: 212 ERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRD 271
            R   + +  SL +F+ P+AIMIVTY         + Y +     +R+            
Sbjct: 222 NR--TYAISSSLISFYIPVAIMIVTY--------TRIYRIAQVQIRRI------------ 259

Query: 272 ETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFF 331
               SS E+ A  + ++  ++      +T +R           +I  E +  K L ++  
Sbjct: 260 ----SSLERAA--EHAQSCRSSAACAPDTSLR----------ASIKKETKVLKTLSVIMG 303

Query: 332 LFLLMWCPFFITNITLVLCDSCNQ-------TTLQMLLEIFVWIGYVSSGVNPLVYTLFN 384
           +F+  W PFFI N  +  C    +          +   ++FVW G+ +S +NP++Y  FN
Sbjct: 304 VFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYA-FN 362

Query: 385 KTFRDAFGRYITCNYRATKS-VKTLRKRSSKIYFRNPMAENSKFFKK--HGIRNGINP 439
             F+  F + + C++  +++ V+T+   +  I +   +  + +      H + N + P
Sbjct: 363 ADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTP 420


>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
          Length = 359

 Score =  132 bits (332), Expect = 7e-31
 Identities = 104/349 (29%), Positives = 164/349 (46%), Gaps = 61/349 (17%)

Query: 64  VIIPTIGGNTLVILAVSLEKKLQ-YATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWP 122
           VI+  I GN LV++AV  +++L+   TNYF++SLA ADLLV + VMP   + ++ + +W 
Sbjct: 29  VILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELV-QDIWI 87

Query: 123 LPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAI-KKPIQANQYNSRATAFIKITVVWL 181
              V C     LDVL +TASI HLC IS+DRY AI  +P+      +     + +   W+
Sbjct: 88  YGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWV 147

Query: 182 ISIGIAIPVPIK------GIETDVD------NPNNITCVLTKERFGDFMLFGSLAAFFTP 229
           I   I+  +PI       GI   ++      N N+  CV    +   + +  S+ AF+ P
Sbjct: 148 IPTFISF-LPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNK--PYAITCSVVAFYIP 204

Query: 230 LAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRK 289
             +M++ Y+      ++ A+ ++              + QR                   
Sbjct: 205 FLLMVLAYYRIYVTAKEHAHQIQ--------------MLQR---------------AGAS 235

Query: 290 DKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVL 349
            ++ P S D+    R  T           E +A+K L I+   F L W PFF+TNI    
Sbjct: 236 SESRPQSADQHSTHRMRT-----------ETKAAKTLCIIMGCFCLCWAPFFVTNIVDPF 284

Query: 350 CDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCN 398
            D    T    +   F+W+GY++SG+NP +Y   NK+FR AF   + C+
Sbjct: 285 ID---YTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCD 330


>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
          Length = 428

 Score =  132 bits (332), Expect = 7e-31
 Identities = 104/349 (29%), Positives = 164/349 (46%), Gaps = 61/349 (17%)

Query: 64  VIIPTIGGNTLVILAVSLEKKLQ-YATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWP 122
           VI+  I GN LV++AV  +++L+   TNYF++SLA ADLLV + VMP   + ++ + +W 
Sbjct: 29  VILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELV-QDIWI 87

Query: 123 LPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAI-KKPIQANQYNSRATAFIKITVVWL 181
              V C     LDVL +TASI HLC IS+DRY AI  +P+      +     + +   W+
Sbjct: 88  YGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWV 147

Query: 182 ISIGIAIPVPIK------GIETDVD------NPNNITCVLTKERFGDFMLFGSLAAFFTP 229
           I   I+  +PI       GI   ++      N N+  CV    +   + +  S+ AF+ P
Sbjct: 148 IPTFISF-LPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNK--PYAITCSVVAFYIP 204

Query: 230 LAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRK 289
             +M++ Y+      ++ A+ ++              + QR                   
Sbjct: 205 FLLMVLAYYRIYVTAKEHAHQIQ--------------MLQR---------------AGAS 235

Query: 290 DKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVL 349
            ++ P S D+    R  T           E +A+K L I+   F L W PFF+TNI    
Sbjct: 236 SESRPQSADQHSTHRMRT-----------ETKAAKTLCIIMGCFCLCWAPFFVTNIVDPF 284

Query: 350 CDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCN 398
            D    T    +   F+W+GY++SG+NP +Y   NK+FR AF   + C+
Sbjct: 285 ID---YTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCD 330


>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
          Length = 360

 Score =  132 bits (332), Expect = 7e-31
 Identities = 104/349 (29%), Positives = 164/349 (46%), Gaps = 61/349 (17%)

Query: 64  VIIPTIGGNTLVILAVSLEKKLQ-YATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWP 122
           VI+  I GN LV++AV  +++L+   TNYF++SLA ADLLV + VMP   + ++ + +W 
Sbjct: 29  VILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELV-QDIWI 87

Query: 123 LPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAI-KKPIQANQYNSRATAFIKITVVWL 181
              V C     LDVL +TASI HLC IS+DRY AI  +P+      +     + +   W+
Sbjct: 88  YGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWV 147

Query: 182 ISIGIAIPVPIK------GIETDVD------NPNNITCVLTKERFGDFMLFGSLAAFFTP 229
           I   I+  +PI       GI   ++      N N+  CV    +   + +  S+ AF+ P
Sbjct: 148 IPTFISF-LPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNK--PYAITCSVVAFYIP 204

Query: 230 LAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRK 289
             +M++ Y+      ++ A+ ++              + QR                   
Sbjct: 205 FLLMVLAYYRIYVTAKEHAHQIQ--------------MLQR---------------AGAS 235

Query: 290 DKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVL 349
            ++ P S D+    R  T           E +A+K L I+   F L W PFF+TNI    
Sbjct: 236 SESRPQSADQHSTHRMRT-----------ETKAAKTLCIIMGCFCLCWAPFFVTNIVDPF 284

Query: 350 CDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCN 398
            D    T    +   F+W+GY++SG+NP +Y   NK+FR AF   + C+
Sbjct: 285 ID---YTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCD 330


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.136    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,805,644
Number of Sequences: 37866
Number of extensions: 625478
Number of successful extensions: 3773
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 488
Number of HSP's successfully gapped in prelim test: 248
Number of HSP's that attempted gapping in prelim test: 2082
Number of HSP's gapped (non-prelim): 1297
length of query: 481
length of database: 18,247,518
effective HSP length: 106
effective length of query: 375
effective length of database: 14,233,722
effective search space: 5337645750
effective search space used: 5337645750
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.