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Search of human proteins with 221625528
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|221625528 granzyme B precursor [Homo sapiens]
(247 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|221625528 granzyme B precursor [Homo sapiens] 515 e-146
gi|15529990 granzyme H [Homo sapiens] 351 3e-97
gi|4503149 cathepsin G preproprotein [Homo sapiens] 293 7e-80
gi|4502907 chymase 1, mast cell preproprotein [Homo sapiens] 243 1e-64
gi|5453676 granzyme A precursor [Homo sapiens] 167 6e-42
gi|71361688 myeloblastin [Homo sapiens] 158 4e-39
gi|91823048 kallikrein 14 preproprotein [Homo sapiens] 158 4e-39
gi|42544239 complement factor D preproprotein [Homo sapiens] 153 1e-37
gi|4506145 protease, serine, 1 preproprotein [Homo sapiens] 149 2e-36
gi|11496281 kallikrein 13 precursor [Homo sapiens] 149 3e-36
gi|209862865 kallikrein 11 isoform 1 preproprotein [Homo sapiens] 148 4e-36
gi|21618357 kallikrein 11 isoform 2 precursor [Homo sapiens] 148 4e-36
gi|5803199 kallikrein 11 isoform 1 preproprotein [Homo sapiens] 148 4e-36
gi|47551347 protease, serine-like 1 [Homo sapiens] 147 8e-36
gi|20302143 kallikrein-related peptidase 15 isoform 4 preproprot... 145 2e-35
gi|21464127 kallikrein 8 isoform 2 [Homo sapiens] 144 5e-35
gi|6005844 kallikrein 8 isoform 1 preproprotein [Homo sapiens] 144 5e-35
gi|4885369 granzyme M precursor [Homo sapiens] 144 9e-35
gi|4504235 granzyme K precursor [Homo sapiens] 142 2e-34
gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens] 137 7e-33
gi|170296790 mesotrypsin isoform 1 preproprotein [Homo sapiens] 135 4e-32
gi|4504875 kallikrein 1 preproprotein [Homo sapiens] 132 2e-31
gi|89142741 kallikrein-related peptidase 4 preproprotein [Homo s... 132 3e-31
gi|4506147 protease, serine, 2 preproprotein [Homo sapiens] 131 5e-31
gi|61744424 kallikrein-related peptidase 6 isoform A preproprote... 131 6e-31
gi|4506155 kallikrein-related peptidase 6 isoform A preproprotei... 131 6e-31
gi|5031829 kallikrein 2, prostatic isoform 1 [Homo sapiens] 130 1e-30
gi|21327705 stratum corneum chymotryptic enzyme preproprotein [H... 128 4e-30
gi|4826950 stratum corneum chymotryptic enzyme preproprotein [Ho... 128 4e-30
gi|117306176 kallikrein-related peptidase 5 preproprotein [Homo ... 125 3e-29
>gi|221625528 granzyme B precursor [Homo sapiens]
Length = 247
Score = 515 bits (1327), Expect = e-146
Identities = 247/247 (100%), Positives = 247/247 (100%)
Query: 1 MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVL 60
MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVL
Sbjct: 1 MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVL 60
Query: 61 TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR 120
TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR
Sbjct: 61 TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR 120
Query: 121 TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY 180
TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY
Sbjct: 121 TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY 180
Query: 181 YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWI 240
YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWI
Sbjct: 181 YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWI 240
Query: 241 KKTMKRY 247
KKTMKRY
Sbjct: 241 KKTMKRY 247
>gi|15529990 granzyme H [Homo sapiens]
Length = 246
Score = 351 bits (901), Expect = 3e-97
Identities = 176/246 (71%), Positives = 194/246 (78%), Gaps = 1/246 (0%)
Query: 1 MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVL 60
MQP LLLLAFLL P A EIIGGHEAKPHSRPYMA++ +KS KRCGG L+R DFVL
Sbjct: 1 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL 60
Query: 61 TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR 120
TAAHC GSSINVTLGAHNIKEQE TQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAK
Sbjct: 61 TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKW 120
Query: 121 TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY 180
T AV+PLRLPS+KAQVKPGQ CSVAGWG + + + TLQEV +TVQ+D +CE
Sbjct: 121 TTAVRPLRLPSSKAQVKPGQLCSVAGWGYVS-MSTLATTLQEVLLTVQKDCQCERLFHGN 179
Query: 181 YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWI 240
Y E+CVGDP+ +T FKGDSGGPLVC VAQGI+SYG G PP KVS F+ WI
Sbjct: 180 YSRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWI 239
Query: 241 KKTMKR 246
K+TMKR
Sbjct: 240 KRTMKR 245
>gi|4503149 cathepsin G preproprotein [Homo sapiens]
Length = 255
Score = 293 bits (751), Expect = 7e-80
Identities = 143/249 (57%), Positives = 185/249 (74%), Gaps = 6/249 (2%)
Query: 1 MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVL 60
MQP+LLLLAFLL A+AGEIIGG E++PHSRPYMAYL I RCGGFL+R+DFVL
Sbjct: 1 MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL 60
Query: 61 TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR 120
TAAHCWGS+INVTLGAHNI+ +E TQQ I +R I HP YN + NDIMLLQL R+ +R
Sbjct: 61 TAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR 120
Query: 121 TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY 180
R V P+ LP + ++PG C+VAGWG+ + + + + TL+EV++ VQ DR+C LR +
Sbjct: 121 NRNVNPVALPRAQEGLRPGTLCTVAGWGRVS-MRRGTDTLREVQLRVQRDRQC---LRIF 176
Query: 181 --YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVH 238
YD ++CVGD +K +FKGDSGGPL+CN VA GIVSYG+++G+PP T+VSSF+
Sbjct: 177 GSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLP 236
Query: 239 WIKKTMKRY 247
WI+ TM+ +
Sbjct: 237 WIRTTMRSF 245
>gi|4502907 chymase 1, mast cell preproprotein [Homo sapiens]
Length = 247
Score = 243 bits (620), Expect = 1e-64
Identities = 131/242 (54%), Positives = 162/242 (66%), Gaps = 3/242 (1%)
Query: 5 LLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYL-MIWDQKSLKRCGGFLIRDDFVLTAA 63
L LL FLL RA+AGEIIGG E KPHSRPYMAYL ++ K CGGFLIR +FVLTAA
Sbjct: 6 LPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAA 65
Query: 64 HCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKRTRA 123
HC G SI VTLGAHNI E+E T Q + V + HP YN +DIMLL+L+ KA T A
Sbjct: 66 HCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLA 125
Query: 124 VQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHYYDS 183
V L PS V PG+ C VAGWG+T L S TLQEVK+ + + + C S R +D
Sbjct: 126 VGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQAC-SHFRD-FDH 183
Query: 184 TIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWIKKT 243
++LCVG+P K++FKGDSGGPL+C VAQGIVSYGR++ PP T++S + WI +
Sbjct: 184 NLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQI 243
Query: 244 MK 245
++
Sbjct: 244 LQ 245
>gi|5453676 granzyme A precursor [Homo sapiens]
Length = 262
Score = 167 bits (424), Expect = 6e-42
Identities = 96/223 (43%), Positives = 130/223 (58%), Gaps = 9/223 (4%)
Query: 6 LLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAAHC 65
++++ LL+P +IIGG+E PHSRPYM L + D+K++ C G LI D+VLTAAHC
Sbjct: 14 VVVSLLLIPEDVCEKIIGGNEVTPHSRPYMVLLSL-DRKTI--CAGALIAKDWVLTAAHC 70
Query: 66 -WGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKRTRAV 124
V LGAH+I +EPT+Q + VK+ P+P Y+P D+ LLQL KAK + V
Sbjct: 71 NLNKRSQVILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLTEKAKINKYV 130
Query: 125 QPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHYYDST 184
L LP VKPG C VAGWG+T S TL+EV +T+ DRK +D HY +
Sbjct: 131 TILHLPKKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVNITI-IDRKVCNDRNHYNFNP 189
Query: 185 I----ELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNN 223
+ +C G + S GDSG PL+C V +G+ S+G N
Sbjct: 190 VIGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLEN 232
>gi|71361688 myeloblastin [Homo sapiens]
Length = 256
Score = 158 bits (400), Expect = 4e-39
Identities = 96/248 (38%), Positives = 132/248 (53%), Gaps = 18/248 (7%)
Query: 6 LLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAAHC 65
+LLA LL A A EI+GGHEA+PHSRPYMA L + CGG LI FVLTAAHC
Sbjct: 13 VLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTLIHPSFVLTAAHC 72
Query: 66 WGS----SINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKRT 121
+NV LGAHN++ QEPTQQ V + + Y+ +N ND++L+QL A +
Sbjct: 73 LRDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLN-NYDAENKLNDVLLIQLSSPANLS 131
Query: 122 RAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHYY 181
+V ++LP V G C GWG+ + LQE+ +TV ++
Sbjct: 132 ASVATVQLPQQDQPVPHGTQCLAMGWGRVGAHDPPAQVLQELNVTVVT----------FF 181
Query: 182 DSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGI---VSYGRNNGMPPRACTKVSSFVH 238
+C P K GDSGGPL+C+ + QGI V +G + P T+V+ +V
Sbjct: 182 CRPHNICTFVPRRKAGICFGDSGGPLICDGIIQGIDSFVIWGCATRLFPDFFTRVALYVD 241
Query: 239 WIKKTMKR 246
WI+ T++R
Sbjct: 242 WIRSTLRR 249
>gi|91823048 kallikrein 14 preproprotein [Homo sapiens]
Length = 267
Score = 158 bits (400), Expect = 4e-39
Identities = 96/254 (37%), Positives = 142/254 (55%), Gaps = 20/254 (7%)
Query: 5 LLLLAFLLLPRA------DAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDF 58
LLL A +L A D +IIGGH S+P+ A L+ ++ CGG L+ +
Sbjct: 19 LLLTALQVLAIAMTQSQEDENKIIGGHTCTRSSQPWQAALLAGPRRRFL-CGGALLSGQW 77
Query: 59 VLTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKA 118
V+TAAHC + V LG HN++ E TQQ + V R + HP YN + ND+MLLQL++ A
Sbjct: 78 VITAAHCGRPILQVALGKHNLRRWEATQQVLRVVRQVTHPNYNSRTHDNDLMLLQLQQPA 137
Query: 119 KRTRAVQPLRLPSNKAQVKPGQTCSVAGWGQ-TAPLGKHSHTLQEVKMTVQEDRKCESDL 177
+ RAV+P+ + +A PG +C V+GWG ++P+ ++ +LQ V + + D C+
Sbjct: 138 RIGRAVRPIEV--TQACASPGTSCRVSGWGTISSPIARYPASLQCVNINISPDEVCQK-- 193
Query: 178 RHYYDSTIE---LCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNN-GMP--PRACT 231
Y TI +C G P+ K S +GDSGGPLVC QG+VS+G +P P T
Sbjct: 194 --AYPRTITPGMVCAGVPQGGKDSCQGDSGGPLVCRGQLQGLVSWGMERCALPGYPGVYT 251
Query: 232 KVSSFVHWIKKTMK 245
+ + WI++TM+
Sbjct: 252 NLCKYRSWIEETMR 265
>gi|42544239 complement factor D preproprotein [Homo sapiens]
Length = 253
Score = 153 bits (387), Expect = 1e-37
Identities = 89/248 (35%), Positives = 127/248 (51%), Gaps = 11/248 (4%)
Query: 4 ILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAA 63
+L+LL G I+GG EA+ H+RPYMA + + CGG L+ + +VL+AA
Sbjct: 9 VLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQL---NGAHLCGGVLVAEQWVLSAA 65
Query: 64 HCWGSS----INVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAK 119
HC + + V LGAH++ + EP+++ V R +PHP P +D++LLQL KA
Sbjct: 66 HCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKAT 125
Query: 120 RTRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRH 179
AV+PL V PG C VAGWG G+ +LQ V + V + C H
Sbjct: 126 LGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHH 185
Query: 180 YYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGR---NNGMPPRACTKVSSF 236
T L + ++ S KGDSGGPLVC V +G+V+ G N P T+V+S+
Sbjct: 186 DGAITERLMCAESN-RRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASY 244
Query: 237 VHWIKKTM 244
WI +
Sbjct: 245 AAWIDSVL 252
>gi|4506145 protease, serine, 1 preproprotein [Homo sapiens]
Length = 247
Score = 149 bits (377), Expect = 2e-36
Identities = 96/250 (38%), Positives = 131/250 (52%), Gaps = 13/250 (5%)
Query: 1 MQPILLLL---AFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDD 57
M P+L+L A L P D +I+GG+ + +S PY L CGG LI +
Sbjct: 1 MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSL----NSGYHFCGGSLINEQ 56
Query: 58 FVLTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERK 117
+V++A HC+ S I V LG HNI+ E +QFI + I HP Y+ K +NDIML++L +
Sbjct: 57 WVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSR 116
Query: 118 AKRTRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLG-KHSHTLQEVKMTVQEDRKCESD 176
A V + LP+ A G C ++GWG TA G + LQ + V KCE+
Sbjct: 117 AVINARVSTISLPT--APPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEAS 174
Query: 177 LRHYYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGM--PPRACTKVS 234
S + CVG E K S +GDSGGP+VCN QG+VS+G P TKV
Sbjct: 175 YPGKITSNM-FCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVY 233
Query: 235 SFVHWIKKTM 244
++V WIK T+
Sbjct: 234 NYVKWIKNTI 243
>gi|11496281 kallikrein 13 precursor [Homo sapiens]
Length = 277
Score = 149 bits (375), Expect = 3e-36
Identities = 94/241 (39%), Positives = 131/241 (54%), Gaps = 19/241 (7%)
Query: 18 AGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAAHCWGSSINVTLGAH 77
+G + GG+ PHS+P+ A L++ + CGG L+ +VLTAAHC + V LG H
Sbjct: 33 SGFLPGGYTCFPHSQPWQAALLV---QGRLLCGGVLVHPKWVLTAAHCLKEGLKVYLGKH 89
Query: 78 NIKEQEPTQQFIPVKRPIPHPAYNPK----NFSNDIMLLQLERKAKRTRAVQPLRLPSNK 133
+ E +Q V IPHP Y N +DIMLL+L+ + T +Q L L N
Sbjct: 90 ALGRVEAGEQVREVVHSIPHPEYRRSPTHLNHDHDIMLLELQSPVQLTGYIQTLPLSHNN 149
Query: 134 AQVKPGQTCSVAGWG-QTAPLGKHSHTLQEVKMTVQEDRKCESDLRHYYDSTIE---LCV 189
++ PG TC V+GWG T+P + TLQ + ++ D +C R Y I LC
Sbjct: 150 -RLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEEC----RQVYPGKITDNMLCA 204
Query: 190 GDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGR-NNGMP--PRACTKVSSFVHWIKKTMKR 246
G E K S +GDSGGPLVCN+ GIVS+G G P P T+VS +V WI++T+++
Sbjct: 205 GTKEGGKDSCEGDSGGPLVCNRTLYGIVSWGDFPCGQPDRPGVYTRVSRYVLWIRETIRK 264
Query: 247 Y 247
Y
Sbjct: 265 Y 265
>gi|209862865 kallikrein 11 isoform 1 preproprotein [Homo sapiens]
Length = 250
Score = 148 bits (374), Expect = 4e-36
Identities = 101/255 (39%), Positives = 141/255 (55%), Gaps = 20/255 (7%)
Query: 1 MQPILLLLAFLLLPRADAGE--IIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDF 58
+Q ILL LA L+ GE II G E KPHS+P+ A L +K+ CG LI +
Sbjct: 4 LQLILLALATGLV----GGETRIIKGFECKPHSQPWQAALF---EKTRLLCGATLIAPRW 56
Query: 59 VLTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYN----PKNFSNDIMLLQL 114
+LTAAHC V LG HN++++E +Q PHP +N K+ NDIML+++
Sbjct: 57 LLTAAHCLKPRYIVHLGQHNLQKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKM 116
Query: 115 ERKAKRTRAVQPLRLPSNKAQVKPGQTCSVAGWGQT-APLGKHSHTLQEVKMTVQEDRKC 173
T AV+PL L S V G +C ++GWG T +P + HTL+ +T+ E +KC
Sbjct: 117 ASPVSITWAVRPLTLSSR--CVTAGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKC 174
Query: 174 ESDLRHYYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNN---GMPPRAC 230
E+ T+ +C E K S +GDSGGPLVCN+ QGI+S+G++ P
Sbjct: 175 ENAYPGNITDTM-VCASVQEGGKDSCQGDSGGPLVCNQSLQGIISWGQDPCAITRKPGVY 233
Query: 231 TKVSSFVHWIKKTMK 245
TKV +V WI++TMK
Sbjct: 234 TKVCKYVDWIQETMK 248
>gi|21618357 kallikrein 11 isoform 2 precursor [Homo sapiens]
Length = 282
Score = 148 bits (374), Expect = 4e-36
Identities = 101/255 (39%), Positives = 141/255 (55%), Gaps = 20/255 (7%)
Query: 1 MQPILLLLAFLLLPRADAGE--IIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDF 58
+Q ILL LA L+ GE II G E KPHS+P+ A L +K+ CG LI +
Sbjct: 36 LQLILLALATGLV----GGETRIIKGFECKPHSQPWQAALF---EKTRLLCGATLIAPRW 88
Query: 59 VLTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYN----PKNFSNDIMLLQL 114
+LTAAHC V LG HN++++E +Q PHP +N K+ NDIML+++
Sbjct: 89 LLTAAHCLKPRYIVHLGQHNLQKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKM 148
Query: 115 ERKAKRTRAVQPLRLPSNKAQVKPGQTCSVAGWGQT-APLGKHSHTLQEVKMTVQEDRKC 173
T AV+PL L S V G +C ++GWG T +P + HTL+ +T+ E +KC
Sbjct: 149 ASPVSITWAVRPLTLSSR--CVTAGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKC 206
Query: 174 ESDLRHYYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNN---GMPPRAC 230
E+ T+ +C E K S +GDSGGPLVCN+ QGI+S+G++ P
Sbjct: 207 ENAYPGNITDTM-VCASVQEGGKDSCQGDSGGPLVCNQSLQGIISWGQDPCAITRKPGVY 265
Query: 231 TKVSSFVHWIKKTMK 245
TKV +V WI++TMK
Sbjct: 266 TKVCKYVDWIQETMK 280
>gi|5803199 kallikrein 11 isoform 1 preproprotein [Homo sapiens]
Length = 250
Score = 148 bits (374), Expect = 4e-36
Identities = 101/255 (39%), Positives = 141/255 (55%), Gaps = 20/255 (7%)
Query: 1 MQPILLLLAFLLLPRADAGE--IIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDF 58
+Q ILL LA L+ GE II G E KPHS+P+ A L +K+ CG LI +
Sbjct: 4 LQLILLALATGLV----GGETRIIKGFECKPHSQPWQAALF---EKTRLLCGATLIAPRW 56
Query: 59 VLTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYN----PKNFSNDIMLLQL 114
+LTAAHC V LG HN++++E +Q PHP +N K+ NDIML+++
Sbjct: 57 LLTAAHCLKPRYIVHLGQHNLQKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKM 116
Query: 115 ERKAKRTRAVQPLRLPSNKAQVKPGQTCSVAGWGQT-APLGKHSHTLQEVKMTVQEDRKC 173
T AV+PL L S V G +C ++GWG T +P + HTL+ +T+ E +KC
Sbjct: 117 ASPVSITWAVRPLTLSSR--CVTAGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKC 174
Query: 174 ESDLRHYYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNN---GMPPRAC 230
E+ T+ +C E K S +GDSGGPLVCN+ QGI+S+G++ P
Sbjct: 175 ENAYPGNITDTM-VCASVQEGGKDSCQGDSGGPLVCNQSLQGIISWGQDPCAITRKPGVY 233
Query: 231 TKVSSFVHWIKKTMK 245
TKV +V WI++TMK
Sbjct: 234 TKVCKYVDWIQETMK 248
>gi|47551347 protease, serine-like 1 [Homo sapiens]
Length = 283
Score = 147 bits (371), Expect = 8e-36
Identities = 102/259 (39%), Positives = 137/259 (52%), Gaps = 18/259 (6%)
Query: 2 QPILLLLAFLLLP-RADAG----EIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRD 56
+P+L + L+LP + AG +IIGGHE PHSRPYMA + Q CGGFL+R
Sbjct: 10 RPLLTVATALMLPVKPPAGSWGAQIIGGHEVTPHSRPYMASVRFGGQH---HCGGFLLRA 66
Query: 57 DFVLTAAHCWGS----SINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLL 112
+V++AAHC+ + V LGAH + EPTQQ + HP Y+P +NDI LL
Sbjct: 67 RWVVSAAHCFSHRDLRTGLVVLGAHVLSTAEPTQQVFGIDALTTHPDYHPMTHANDICLL 126
Query: 113 QLERKAKRTRAVQPLRLPSNKAQ-VKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDR 171
+L A AV LRLP +A+ G C VAGWG + + L E K+ V +
Sbjct: 127 RLNGSAVLGPAVGLLRLPGRRARPPTAGTRCRVAGWGFVSDFEELPPGLMEAKVRVLDPD 186
Query: 172 KCESDLRHYYDSTIELCVGDPEIKKTSF-KGDSGGPLVCNKVAQGIVSY-GRNNGMP--P 227
C S + + T+ LC + + F DSGGPLVC A G+VS+ G G P P
Sbjct: 187 VCNSSWKGHLTLTM-LCTRSGDSHRRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTP 245
Query: 228 RACTKVSSFVHWIKKTMKR 246
T+VS+FV WI ++R
Sbjct: 246 DVYTQVSAFVAWIWDVVRR 264
>gi|20302143 kallikrein-related peptidase 15 isoform 4 preproprotein
[Homo sapiens]
Length = 256
Score = 145 bits (367), Expect = 2e-35
Identities = 92/259 (35%), Positives = 136/259 (52%), Gaps = 22/259 (8%)
Query: 4 ILLLLAFLLLPRA--DAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLT 61
+LL L+FLL A D +++ G E PHS+P+ L ++ CG LI +VL+
Sbjct: 3 LLLTLSFLLASTAAQDGDKLLEGDECAPHSQPWQVALY---ERGRFNCGASLISPHWVLS 59
Query: 62 AAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKRT 121
AAHC + V LG HN+++++ +Q R IPHP Y ++ NDIMLL+L + A+
Sbjct: 60 AAHCQSRFMRVRLGEHNLRKRDGPEQLRTTSRVIPHPRYEARSHRNDIMLLRLVQPARLN 119
Query: 122 RAVQPLRLPSNKAQVKPGQTCSVAGWGQT---------APLGKHS--HTLQEVKMTVQED 170
V+P LP+ PG+ C V+GWG +P + S TL +++ D
Sbjct: 120 PQVRPAVLPTRCPH--PGEACVVSGWGLVSHNEPGTAGSPRSQVSLPDTLHCANISIISD 177
Query: 171 RKCESDLRHYYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGR---NNGMPP 227
C+ +T+ +C G S +GDSGGPLVC + QGIVS+G +N P
Sbjct: 178 TSCDKSYPGRLTNTM-VCAGAEGRGAESCEGDSGGPLVCGGILQGIVSWGDVPCDNTTKP 236
Query: 228 RACTKVSSFVHWIKKTMKR 246
TKV ++ WI++TMKR
Sbjct: 237 GVYTKVCHYLEWIRETMKR 255
>gi|21464127 kallikrein 8 isoform 2 [Homo sapiens]
Length = 305
Score = 144 bits (364), Expect = 5e-35
Identities = 87/235 (37%), Positives = 129/235 (54%), Gaps = 14/235 (5%)
Query: 15 RADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAAHCWGSSINVTL 74
RA +++GGHE +PHS+P+ A L Q CGG L+ ++VLTAAHC V L
Sbjct: 72 RAQEDKVLGGHECQPHSQPWQAALF---QGQQLLCGGVLVGGNWVLTAAHCKKPKYTVRL 128
Query: 75 GAHNIKEQEPTQQFIPVKRPIPHPAYNP---KNFSNDIMLLQLERKAKRTRAVQPLRLPS 131
G H+++ ++ +Q IPV + IPHP YN ++ ++D+MLLQL +A V+P+ L
Sbjct: 129 GDHSLQNKDGPEQEIPVVQSIPHPCYNSSDVEDHNHDLMLLQLRDQASLGSKVKPISLAD 188
Query: 132 NKAQVKPGQTCSVAGWGQ-TAPLGKHSHTLQEVKMTVQEDRKCESDLRHYYDSTIELCVG 190
+ Q PGQ C+V+GWG T+P TL ++ + +KCE + +C G
Sbjct: 189 HCTQ--PGQKCTVSGWGTVTSPRENFPDTLNCAEVKIFPQKKCEDAYPGQITDGM-VCAG 245
Query: 191 DPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRN---NGMPPRACTKVSSFVHWIKK 242
+ T +GDSGGPLVC+ QGI S+G + P T + ++ WIKK
Sbjct: 246 SSKGADTC-QGDSGGPLVCDGALQGITSWGSDPCGRSDKPGVYTNICRYLDWIKK 299
>gi|6005844 kallikrein 8 isoform 1 preproprotein [Homo sapiens]
Length = 260
Score = 144 bits (364), Expect = 5e-35
Identities = 87/235 (37%), Positives = 129/235 (54%), Gaps = 14/235 (5%)
Query: 15 RADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAAHCWGSSINVTL 74
RA +++GGHE +PHS+P+ A L Q CGG L+ ++VLTAAHC V L
Sbjct: 27 RAQEDKVLGGHECQPHSQPWQAALF---QGQQLLCGGVLVGGNWVLTAAHCKKPKYTVRL 83
Query: 75 GAHNIKEQEPTQQFIPVKRPIPHPAYNP---KNFSNDIMLLQLERKAKRTRAVQPLRLPS 131
G H+++ ++ +Q IPV + IPHP YN ++ ++D+MLLQL +A V+P+ L
Sbjct: 84 GDHSLQNKDGPEQEIPVVQSIPHPCYNSSDVEDHNHDLMLLQLRDQASLGSKVKPISLAD 143
Query: 132 NKAQVKPGQTCSVAGWGQ-TAPLGKHSHTLQEVKMTVQEDRKCESDLRHYYDSTIELCVG 190
+ Q PGQ C+V+GWG T+P TL ++ + +KCE + +C G
Sbjct: 144 HCTQ--PGQKCTVSGWGTVTSPRENFPDTLNCAEVKIFPQKKCEDAYPGQITDGM-VCAG 200
Query: 191 DPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRN---NGMPPRACTKVSSFVHWIKK 242
+ T +GDSGGPLVC+ QGI S+G + P T + ++ WIKK
Sbjct: 201 SSKGADTC-QGDSGGPLVCDGALQGITSWGSDPCGRSDKPGVYTNICRYLDWIKK 254
>gi|4885369 granzyme M precursor [Homo sapiens]
Length = 257
Score = 144 bits (362), Expect = 9e-35
Identities = 91/255 (35%), Positives = 132/255 (51%), Gaps = 20/255 (7%)
Query: 4 ILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAA 63
++L L L + + +IIGG E PHSRPYMA L + CGG L+ +VLTAA
Sbjct: 9 LVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQ---RNGSHLCGGVLVHPKWVLTAA 65
Query: 64 HCWG---SSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNP-KNFSNDIMLLQLERKAK 119
HC + + + LG H + T +K I HP Y P ND+ LLQL+ K K
Sbjct: 66 HCLAQRMAQLRLVLGLHTLDSPGLT---FHIKAAIQHPRYKPVPALENDLALLQLDGKVK 122
Query: 120 RTRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRH 179
+R ++PL LPS + V G CS+AGWG T G+ S L+E+ + V + R C +
Sbjct: 123 PSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNS--R 180
Query: 180 YYDSTIE---LCVGDPEIKKTSFKGDSGGPLVCNK--VAQGIVSYGR---NNGMPPRACT 231
+++ ++ +C+ + KGDSGGPLVC K V G++S+ + P T
Sbjct: 181 FWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVAT 240
Query: 232 KVSSFVHWIKKTMKR 246
V+ +V WI+K R
Sbjct: 241 AVAPYVSWIRKVTGR 255
>gi|4504235 granzyme K precursor [Homo sapiens]
Length = 264
Score = 142 bits (359), Expect = 2e-34
Identities = 93/237 (39%), Positives = 124/237 (52%), Gaps = 16/237 (6%)
Query: 20 EIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAAHCW-----GSSINVTL 74
EIIGG E PHSRP+MA + CGG LI +VLTAAHC G S V L
Sbjct: 26 EIIGGKEVSPHSRPFMASIQYGGHHV---CGGVLIDPQWVLTAAHCQYRFTKGQSPTVVL 82
Query: 75 GAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKRTRAVQPLRLPSNKA 134
GAH++ + E ++Q + +K+ IP SNDIML++L+ AK + V+ L + S K
Sbjct: 83 GAHSLSKNEASKQTLEIKKFIPFSRVTSDPQSNDIMLVKLQTAAKLNKHVKMLHIRS-KT 141
Query: 135 QVKPGQTCSVAGWGQTAPLG-KHSHTLQEVKMTVQEDRKCESDLRHYYDSTIE---LCVG 190
++ G C V GWG T P + S TL+EV +TV + C S + D I +C G
Sbjct: 142 SLRSGTKCKVTGWGATDPDSLRPSDTLREVTVTVLSRKLCNSQSYYNGDPFITKDMVCAG 201
Query: 191 DPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGM---PPRACTKVSSFVHWIKKTM 244
D + +K S KGDSGGPL+C V IVS G G+ P + WIK +
Sbjct: 202 DAKGQKDSCKGDSGGPLICKGVFHAIVSGGHECGVATKPGIYTLLTKKYQTWIKSNL 258
>gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens]
Length = 247
Score = 137 bits (346), Expect = 7e-33
Identities = 90/250 (36%), Positives = 128/250 (51%), Gaps = 13/250 (5%)
Query: 1 MQPILLLL---AFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDD 57
M P L+L A + +P D +I+GG+ + +S PY L CGG LI +
Sbjct: 1 MNPFLILAFVGAAVAVPFDDDDKIVGGYTCEENSLPYQVSL----NSGSHFCGGSLISEQ 56
Query: 58 FVLTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERK 117
+V++AAHC+ + I V LG HNIK E +QFI + I HP YN NDIML++L
Sbjct: 57 WVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSP 116
Query: 118 AKRTRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLG-KHSHTLQEVKMTVQEDRKCESD 176
A V + LP+ A G C ++GWG T G + L+ + V +C++
Sbjct: 117 AVINARVSTISLPT--APPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKAS 174
Query: 177 LRHYYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMP--PRACTKVS 234
+++ CVG E K S + DSGGP+VCN QG+VS+G P TKV
Sbjct: 175 YPGKITNSM-FCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWKNRPGVYTKVY 233
Query: 235 SFVHWIKKTM 244
++V WIK T+
Sbjct: 234 NYVDWIKDTI 243
>gi|170296790 mesotrypsin isoform 1 preproprotein [Homo sapiens]
Length = 304
Score = 135 bits (339), Expect = 4e-32
Identities = 86/240 (35%), Positives = 123/240 (51%), Gaps = 10/240 (4%)
Query: 8 LAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAAHCWG 67
L + +P D +I+GG+ + +S PY L CGG LI + +V++AAHC+
Sbjct: 68 LGTVAVPFDDDDKIVGGYTCEENSLPYQVSL----NSGSHFCGGSLISEQWVVSAAHCYK 123
Query: 68 SSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKRTRAVQPL 127
+ I V LG HNIK E +QFI + I HP YN NDIML++L A V +
Sbjct: 124 TRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTI 183
Query: 128 RLPSNKAQVKPGQTCSVAGWGQTAPLG-KHSHTLQEVKMTVQEDRKCESDLRHYYDSTIE 186
LP+ A G C ++GWG T G + L+ + V +C++ +++
Sbjct: 184 SLPT--APPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSM- 240
Query: 187 LCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMP--PRACTKVSSFVHWIKKTM 244
CVG E K S + DSGGP+VCN QG+VS+G P TKV ++V WIK T+
Sbjct: 241 FCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWKNRPGVYTKVYNYVDWIKDTI 300
>gi|4504875 kallikrein 1 preproprotein [Homo sapiens]
Length = 262
Score = 132 bits (333), Expect = 2e-31
Identities = 88/241 (36%), Positives = 128/241 (53%), Gaps = 24/241 (9%)
Query: 21 IIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAAHCWGSSINVTLGAHNIK 80
I+GG E + HS+P+ A L + S +CGG L+ +VLTAAHC + + LG HN+
Sbjct: 25 IVGGWECEQHSQPWQAALYHF---STFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLF 81
Query: 81 EQEPTQQFIPVKRPIPHPAYN-----------PKNFSNDIMLLQLERKAKR-TRAVQPLR 128
+ E T QF+ V PHP +N +++S+D+MLL+L A T AV+ +
Sbjct: 82 DDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVE 141
Query: 129 LPSNKAQVKPGQTCSVAGWGQTAPLG-KHSHTLQEVKMTVQEDRKCESDLRHYYDST-IE 186
LP+ + +V G TC +GWG P LQ V + + + +C+ H T
Sbjct: 142 LPTEEPEV--GSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKK--AHVQKVTDFM 197
Query: 187 LCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGR-NNGMP--PRACTKVSSFVHWIKKT 243
LCVG E K + GDSGGPL+C+ V QG+ S+G G P P +V S+V WI+ T
Sbjct: 198 LCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDT 257
Query: 244 M 244
+
Sbjct: 258 I 258
>gi|89142741 kallikrein-related peptidase 4 preproprotein [Homo
sapiens]
Length = 254
Score = 132 bits (332), Expect = 3e-31
Identities = 76/237 (32%), Positives = 123/237 (51%), Gaps = 11/237 (4%)
Query: 13 LPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAAHCWGSSINV 72
L +II G + PHS+P+ A L++ ++ C G L+ +VL+AAHC+ +S +
Sbjct: 23 LVSGSCSQIINGEDCSPHSQPWQAALVMENELF---CSGVLVHPQWVLSAAHCFQNSYTI 79
Query: 73 TLGAHNIK-EQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKRTRAVQPLRLPS 131
LG H+++ +QEP Q + + HP YN +ND+ML++L+ + ++ + + S
Sbjct: 80 GLGLHSLEADQEPGSQMVEASLSVRHPEYNRPLLANDLMLIKLDESVSESDTIRSISIAS 139
Query: 132 NKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHYYDSTIELCVGD 191
G +C V+GWG A G+ LQ V ++V + C Y ++ C G
Sbjct: 140 QCPTA--GNSCLVSGWGLLAN-GRMPTVLQCVNVSVVSEEVCSKLYDPLYHPSM-FCAGG 195
Query: 192 PEIKKTSFKGDSGGPLVCNKVAQGIVSYGR---NNGMPPRACTKVSSFVHWIKKTMK 245
+K S GDSGGPL+CN QG+VS+G+ P T + F WI+KT++
Sbjct: 196 GHDQKDSCNGDSGGPLICNGYLQGLVSFGKAPCGQVGVPGVYTNLCKFTEWIEKTVQ 252
>gi|4506147 protease, serine, 2 preproprotein [Homo sapiens]
Length = 247
Score = 131 bits (330), Expect = 5e-31
Identities = 90/248 (36%), Positives = 125/248 (50%), Gaps = 14/248 (5%)
Query: 4 ILLLLAFLLL----PRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFV 59
+LL+L F+ P D +I+GG+ + +S PY L CGG LI + +V
Sbjct: 3 LLLILTFVAAAVAAPFDDDDKIVGGYICEENSVPYQVSL----NSGYHFCGGSLISEQWV 58
Query: 60 LTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAK 119
++A HC+ S I V LG HNI+ E +QFI + I HP YN + NDI+L++L A
Sbjct: 59 VSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPKYNSRTLDNDILLIKLSSPAV 118
Query: 120 RTRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLG-KHSHTLQEVKMTVQEDRKCESDLR 178
V + LP+ A G ++GWG T G + LQ + V +CE+
Sbjct: 119 INSRVSAISLPT--APPAAGTESLISGWGNTLSSGADYPDELQCLDAPVLSQAECEASYP 176
Query: 179 HYYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVS--YGRNNGMPPRACTKVSSF 236
+ + CVG E K S +GDSGGP+V N QGIVS YG P TKV ++
Sbjct: 177 GKITNNM-FCVGFLEGGKDSCQGDSGGPVVSNGELQGIVSWGYGCAQKNRPGVYTKVYNY 235
Query: 237 VHWIKKTM 244
V WIK T+
Sbjct: 236 VDWIKDTI 243
>gi|61744424 kallikrein-related peptidase 6 isoform A preproprotein
[Homo sapiens]
Length = 244
Score = 131 bits (329), Expect = 6e-31
Identities = 86/252 (34%), Positives = 131/252 (51%), Gaps = 17/252 (6%)
Query: 1 MQPILLLLAFLLLPRADA-GEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFV 59
M+ ++++L+ + A+ +++ G S PY A L CGG LI +V
Sbjct: 1 MKKLMVVLSLIAAAWAEEQNKLVHGGPCDKTSHPYQAALYT---SGHLLCGGVLIHPLWV 57
Query: 60 LTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAK 119
LTAAHC ++ V LG HN++++E +Q+ V R + HP Y+ + DIMLL+L R AK
Sbjct: 58 LTAAHCKKPNLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAK 117
Query: 120 RTRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRH 179
+ +QP LP + +C + GWG+TA G T+Q + + +CE H
Sbjct: 118 LSELIQP--LPLERDCSANTTSCHILGWGKTAD-GDFPDTIQCAYIHLVSREECE----H 170
Query: 180 YYDSTIE---LCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGR---NNGMPPRACTKV 233
Y I LC GD + K S +GDSGGPLVC +G+VS+G + P T V
Sbjct: 171 AYPGQITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNV 230
Query: 234 SSFVHWIKKTMK 245
+ +WI+KT++
Sbjct: 231 CRYTNWIQKTIQ 242
>gi|4506155 kallikrein-related peptidase 6 isoform A preproprotein
[Homo sapiens]
Length = 244
Score = 131 bits (329), Expect = 6e-31
Identities = 86/252 (34%), Positives = 131/252 (51%), Gaps = 17/252 (6%)
Query: 1 MQPILLLLAFLLLPRADA-GEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFV 59
M+ ++++L+ + A+ +++ G S PY A L CGG LI +V
Sbjct: 1 MKKLMVVLSLIAAAWAEEQNKLVHGGPCDKTSHPYQAALYT---SGHLLCGGVLIHPLWV 57
Query: 60 LTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAK 119
LTAAHC ++ V LG HN++++E +Q+ V R + HP Y+ + DIMLL+L R AK
Sbjct: 58 LTAAHCKKPNLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAK 117
Query: 120 RTRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRH 179
+ +QP LP + +C + GWG+TA G T+Q + + +CE H
Sbjct: 118 LSELIQP--LPLERDCSANTTSCHILGWGKTAD-GDFPDTIQCAYIHLVSREECE----H 170
Query: 180 YYDSTIE---LCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGR---NNGMPPRACTKV 233
Y I LC GD + K S +GDSGGPLVC +G+VS+G + P T V
Sbjct: 171 AYPGQITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNV 230
Query: 234 SSFVHWIKKTMK 245
+ +WI+KT++
Sbjct: 231 CRYTNWIQKTIQ 242
>gi|5031829 kallikrein 2, prostatic isoform 1 [Homo sapiens]
Length = 261
Score = 130 bits (326), Expect = 1e-30
Identities = 90/241 (37%), Positives = 120/241 (49%), Gaps = 25/241 (10%)
Query: 21 IIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAAHCWGSSINVTLGAHNIK 80
I+GG E + HS+P+ + CGG L+ +VLTAAHC + V LG HN+
Sbjct: 25 IVGGWECEKHSQPWQVAVY---SHGWAHCGGVLVHPQWVLTAAHCLKKNSQVWLGRHNLF 81
Query: 81 EQEPTQQFIPVKRPIPHPAYN-----------PKNFSNDIMLLQLERKAKRTRAVQPLRL 129
E E T Q +PV PHP YN ++ S+D+MLL+L AK T V+ L L
Sbjct: 82 EPEDTGQRVPVSHSFPHPLYNMSLLKHQSLRPDEDSSHDLMLLRLSEPAKITDVVKVLGL 141
Query: 130 PSNKAQVKPGQTCSVAGWGQTAPLG-KHSHTLQEVKMTVQEDRKCESDLRHYYDSTIE-- 186
P+ + + G TC +GWG P +LQ V + + + C R Y + E
Sbjct: 142 PTQEPAL--GTTCYASGWGSIEPEEFLRPRSLQCVSLHLLSNDMC---ARAYSEKVTEFM 196
Query: 187 LCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNN-GMP--PRACTKVSSFVHWIKKT 243
LC G K + GDSGGPLVCN V QGI S+G +P P TKV + WIK T
Sbjct: 197 LCAGLWTGGKDTCGGDSGGPLVCNGVLQGITSWGPEPCALPEKPAVYTKVVHYRKWIKDT 256
Query: 244 M 244
+
Sbjct: 257 I 257
>gi|21327705 stratum corneum chymotryptic enzyme preproprotein [Homo
sapiens]
Length = 253
Score = 128 bits (322), Expect = 4e-30
Identities = 87/253 (34%), Positives = 130/253 (51%), Gaps = 16/253 (6%)
Query: 3 PILLLLAFLLLP----RADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDF 58
P+ +LL L L A +II G S P+ L+ +Q CGG L+ + +
Sbjct: 8 PLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQL---HCGGVLVNERW 64
Query: 59 VLTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKA 118
VLTAAHC + V LG+ + ++ Q I + HP Y+ + ND+ML++L +A
Sbjct: 65 VLTAAHCKMNEYTVHLGSDTLGDRRA--QRIKASKSFRHPGYSTQTHVNDLMLVKLNSQA 122
Query: 119 KRTRAVQPLRLPSNKAQVKPGQTCSVAGWGQT-APLGKHSHTLQEVKMTVQEDRKCESDL 177
+ + V+ +RLPS PG TC+V+GWG T +P L V + + + C
Sbjct: 123 RLSSMVKKVRLPSRCEP--PGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVY 180
Query: 178 RHYYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGR-NNGMP--PRACTKVS 234
+ ++++ LC G P+ KK + GDSGGPLVC QG+VS+G G P P T+V
Sbjct: 181 KDLLENSM-LCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVC 239
Query: 235 SFVHWIKKTMKRY 247
F WI TMK++
Sbjct: 240 KFTKWINDTMKKH 252
>gi|4826950 stratum corneum chymotryptic enzyme preproprotein [Homo
sapiens]
Length = 253
Score = 128 bits (322), Expect = 4e-30
Identities = 87/253 (34%), Positives = 130/253 (51%), Gaps = 16/253 (6%)
Query: 3 PILLLLAFLLLP----RADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDF 58
P+ +LL L L A +II G S P+ L+ +Q CGG L+ + +
Sbjct: 8 PLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQL---HCGGVLVNERW 64
Query: 59 VLTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKA 118
VLTAAHC + V LG+ + ++ Q I + HP Y+ + ND+ML++L +A
Sbjct: 65 VLTAAHCKMNEYTVHLGSDTLGDRRA--QRIKASKSFRHPGYSTQTHVNDLMLVKLNSQA 122
Query: 119 KRTRAVQPLRLPSNKAQVKPGQTCSVAGWGQT-APLGKHSHTLQEVKMTVQEDRKCESDL 177
+ + V+ +RLPS PG TC+V+GWG T +P L V + + + C
Sbjct: 123 RLSSMVKKVRLPSRCEP--PGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVY 180
Query: 178 RHYYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGR-NNGMP--PRACTKVS 234
+ ++++ LC G P+ KK + GDSGGPLVC QG+VS+G G P P T+V
Sbjct: 181 KDLLENSM-LCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVC 239
Query: 235 SFVHWIKKTMKRY 247
F WI TMK++
Sbjct: 240 KFTKWINDTMKKH 252
>gi|117306176 kallikrein-related peptidase 5 preproprotein [Homo
sapiens]
Length = 293
Score = 125 bits (315), Expect = 3e-29
Identities = 79/235 (33%), Positives = 125/235 (53%), Gaps = 15/235 (6%)
Query: 18 AGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAAHCWGSSINVTLGAH 77
+ II G + H++P+ A L++ + + CG L+ ++LTAAHC V LG +
Sbjct: 64 SSRIINGSDCDMHTQPWQAALLL--RPNQLYCGAVLVHPQWLLTAAHCRKKVFRVRLGHY 121
Query: 78 NIKE-QEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKRTRAVQPLRLPSNKAQV 136
++ E QQ + IPHP Y+ SND+ML++L R+ + T+ V+P+ + S+
Sbjct: 122 SLSPVYESGQQMFQGVKSIPHPGYSHPGHSNDLMLIKLNRRIRPTKDVRPINVSSHCPSA 181
Query: 137 KPGQTCSVAGWGQT-APLGKHSHTLQEVKMTVQEDRKCESDLRHYYDSTIELCVGDPEIK 195
G C V+GWG T +P LQ + ++V ++CE D T+ C GD +
Sbjct: 182 --GTKCLVSGWGTTKSPQVHFPKVLQCLNISVLSQKRCEDAYPRQIDDTM-FCAGD-KAG 237
Query: 196 KTSFKGDSGGPLVCNKVAQGIVSYG-----RNNGMPPRACTKVSSFVHWIKKTMK 245
+ S +GDSGGP+VCN QG+VS+G R N P T + F WI++T++
Sbjct: 238 RDSCQGDSGGPVVCNGSLQGLVSWGDYPCARPN--RPGVYTNLCKFTKWIQETIQ 290
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,522,166
Number of Sequences: 37866
Number of extensions: 480093
Number of successful extensions: 1729
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 160
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 1133
Number of HSP's gapped (non-prelim): 193
length of query: 247
length of database: 18,247,518
effective HSP length: 100
effective length of query: 147
effective length of database: 14,460,918
effective search space: 2125754946
effective search space used: 2125754946
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.