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Search of human proteins with 22035604
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22035604 mitogen-activated protein kinase kinase kinase
kinase 4 isoform 2 [Homo sapiens]
(1320 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 2651 0.0
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 2036 0.0
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 1696 0.0
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 1695 0.0
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 1644 0.0
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 1643 0.0
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 1637 0.0
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 1637 0.0
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 1576 0.0
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 1576 0.0
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 1552 0.0
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 1550 0.0
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 1547 0.0
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 1544 0.0
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 1267 0.0
gi|118600963 Nik related kinase [Homo sapiens] 419 e-117
gi|145275208 myosin IIIA [Homo sapiens] 306 1e-82
gi|134288915 myosin IIIB isoform 1 [Homo sapiens] 296 9e-80
gi|134288892 myosin IIIB isoform 2 [Homo sapiens] 296 9e-80
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 269 1e-71
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 267 4e-71
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 259 9e-69
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 256 8e-68
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 256 8e-68
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 252 1e-66
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 248 3e-65
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 243 1e-63
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 243 1e-63
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 241 3e-63
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 239 1e-62
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 2651 bits (6872), Expect = 0.0
Identities = 1320/1320 (100%), Positives = 1320/1320 (100%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE
Sbjct: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
Query: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540
VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP
Sbjct: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540
Query: 541 PPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRS 600
PPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRS
Sbjct: 541 PPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRS 600
Query: 601 ESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQD 660
ESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQD
Sbjct: 601 ESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQD 660
Query: 661 PCPPSRSEVLSQSSDSKSEAPDPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRDSPLQG 720
PCPPSRSEVLSQSSDSKSEAPDPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRDSPLQG
Sbjct: 661 PCPPSRSEVLSQSSDSKSEAPDPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRDSPLQG 720
Query: 721 SGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGE 780
SGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGE
Sbjct: 721 SGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGE 780
Query: 781 RFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPH 840
RFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPH
Sbjct: 781 RFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPH 840
Query: 841 KVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHD 900
KVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHD
Sbjct: 841 KVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHD 900
Query: 901 DVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTSVV 960
DVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTSVV
Sbjct: 901 DVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTSVV 960
Query: 961 GFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNL 1020
GFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNL
Sbjct: 961 GFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNL 1020
Query: 1021 LVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRN 1080
LVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRN
Sbjct: 1021 LVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRN 1080
Query: 1081 KILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFM 1140
KILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFM
Sbjct: 1081 KILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFM 1140
Query: 1141 AFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKP 1200
AFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKP
Sbjct: 1141 AFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKP 1200
Query: 1201 HAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEK 1260
HAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEK
Sbjct: 1201 HAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEK 1260
Query: 1261 AIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW 1320
AIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW
Sbjct: 1261 AIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW 1320
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 2036 bits (5274), Expect = 0.0
Identities = 1069/1320 (80%), Positives = 1116/1320 (84%), Gaps = 108/1320 (8%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
QENKERSEA L+ QQL L+EQQ RE+E
Sbjct: 361 QENKERSEA------LRRQQL---------------------------LQEQQLREQEEY 387
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
++Q +R++ E+++ E+RR+ EE++RR E +R+ EREQ RR+ +EE+R LE
Sbjct: 388 KRQLLAERQKRIEQQK-----EQRRRLEEQQRREREARRQQEREQ---RRREQEEKRRLE 439
Query: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540
L++ R +E EE R+AE +R++++EQ Y+ + +R
Sbjct: 440 ELER------------RRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQR---------- 477
Query: 541 PPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRS 600
H E + E +H P Q Q +PP P +
Sbjct: 478 ------------------HLEVLQQQLLQEQAMLLHDHRRPHPQHSQ-----QPPPPQQE 514
Query: 601 ESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQD 660
S P+ P EP+ + A V R + S P + + R +
Sbjct: 515 RS---------KPSFHAP-EPKAHYEP-ADRAREVEDRFRKTNHSSPEAQ-SKQTGRVLE 562
Query: 661 PCPPSRSEVLSQSSDSKSEAPDPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRDSPLQG 720
P PSRSE S + SE+ P + P+VPVRTTSRSPVLSRRDSPLQG
Sbjct: 563 PPVPSRSESFSNGN---SESVHPALQR-------PAEPQVPVRTTSRSPVLSRRDSPLQG 612
Query: 721 SGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGE 780
SGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGE
Sbjct: 613 SGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGE 672
Query: 781 RFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPH 840
RFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPH
Sbjct: 673 RFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPH 732
Query: 841 KVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHD 900
KVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHD
Sbjct: 733 KVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHD 792
Query: 901 DVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTSVV 960
DVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTSVV
Sbjct: 793 DVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTSVV 852
Query: 961 GFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNL 1020
GFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNL
Sbjct: 853 GFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNL 912
Query: 1021 LVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRN 1080
LVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRN
Sbjct: 913 LVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRN 972
Query: 1081 KILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFM 1140
KILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFM
Sbjct: 973 KILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFM 1032
Query: 1141 AFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKP 1200
AFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKP
Sbjct: 1033 AFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKP 1092
Query: 1201 HAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEK 1260
HAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEK
Sbjct: 1093 HAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEK 1152
Query: 1261 AIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW 1320
AIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW
Sbjct: 1153 AIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW 1212
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 1696 bits (4391), Expect = 0.0
Identities = 915/1391 (65%), Positives = 1044/1391 (75%), Gaps = 110/1391 (7%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
+QQEREQRR +E+ RR EEE+RR E EQEYIRRQLEEEQR LE
Sbjct: 417 KQQEREQRRHYEEQMRR-----------------EEERRRAEHEQEYIRRQLEEEQRQLE 459
Query: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540
+LQQQLL EQA+LLE + +++EE RQAERLQRQL+QE+ YL+SLQH + P
Sbjct: 460 ILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRP------- 512
Query: 541 PPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRS 600
KP +H E + E A+EVE+R R SSP K R+ +P +P RS
Sbjct: 513 ----VEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRS 568
Query: 601 ESFS-NGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQ 659
ESFS +G + P + RP +PQ+ HL ++K+ ++ S S + K +
Sbjct: 569 ESFSISGVQPARTPPMLRPVDPQI--PHLVAVKSQGPALTASQSVHEQPTKGLSGFQEAL 626
Query: 660 DPCPPSRSEVLSQSSDSKSEAPD-PT------QKAWSRSDSDEVPPRVPVRTTSRSPVLS 712
+ R E+ Q+SD SE P PT + +W R + D +PP+VP RTTS SP L+
Sbjct: 627 N-VTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEED-IPPKVPQRTTSISPALA 684
Query: 713 RRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP---- 768
R++SP GS Q S+ + R +E + R SGSSS SS SQP
Sbjct: 685 RKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQG 744
Query: 769 GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAK 828
GS PGSQ+GS ER RVR++SKSEGSP E A KPE+ +++ RP +PA DLTALAK
Sbjct: 745 GSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA---DLTALAK 801
Query: 829 ELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNL 885
ELR + E RP KVTDYSSSSEES +++EE++D E E D + + + R +
Sbjct: 802 ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP 861
Query: 886 SNGETESVKTMIVHDDVESEP---AMTPSKEGTLIVRQT--------QSASSTLQKH--- 931
+ E +V + H S + + S+EGTL++R+T S S+ H
Sbjct: 862 GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINL 921
Query: 932 --------------------------------------KSSSSFTPFIDPRLLQISPS-- 951
+ +SFTPF+DPR+ Q SP+
Sbjct: 922 PDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDE 981
Query: 952 --SGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSE 1009
++ F+ + +R E + + RK SVVNVNPTN RP SDTPEIRKYKKRFNSE
Sbjct: 982 DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE 1041
Query: 1010 ILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDK 1069
ILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLEGLNVLVTISGKK+K
Sbjct: 1042 ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK 1101
Query: 1070 LRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVY 1129
LRVYYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERIKFLVIALK++VE+Y
Sbjct: 1102 LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY 1161
Query: 1130 AWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIY 1189
AWAPKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS GFH +DVDSG+ YDIY
Sbjct: 1162 AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY 1221
Query: 1190 LPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI 1249
+P+HIQ +I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI
Sbjct: 1222 IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI 1281
Query: 1250 RSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYF 1309
SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+F
Sbjct: 1282 HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF 1341
Query: 1310 MTLGRTSLLSW 1320
MTL R S+++W
Sbjct: 1342 MTLNRNSMMNW 1352
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sapiens]
Length = 1360
Score = 1695 bits (4389), Expect = 0.0
Identities = 915/1396 (65%), Positives = 1045/1396 (74%), Gaps = 112/1396 (8%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
+QQEREQRR +E+ RR EEE+RR E EQEYIRRQLEEEQR LE
Sbjct: 417 KQQEREQRRHYEEQMRR-----------------EEERRRAEHEQEYIRRQLEEEQRQLE 459
Query: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540
+LQQQLL EQA+LLE + +++EE RQAERLQRQL+QE+ YL+SLQH + P
Sbjct: 460 ILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRP------- 512
Query: 541 PPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRS 600
KP +H E + E A+EVE+R R SSP K R+ +P +P RS
Sbjct: 513 ----VEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRS 568
Query: 601 ESFS-NGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQ 659
ESFS +G + P + RP +PQ+ HL ++K+ ++ S S + K +
Sbjct: 569 ESFSISGVQPARTPPMLRPVDPQI--PHLVAVKSQGPALTASQSVHEQPTKGLSGFQEAL 626
Query: 660 DPCPPSRSEVLSQSSDSKSEAPD-PT------QKAWSRSDSDEVPPRVPVRTTSRSPVLS 712
+ R E+ Q+SD SE P PT + +W R + D +PP+VP RTTS SP L+
Sbjct: 627 N-VTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEED-IPPKVPQRTTSISPALA 684
Query: 713 RRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP---- 768
R++SP GS Q S+ + R +E + R SGSSS SS SQP
Sbjct: 685 RKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQG 744
Query: 769 GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAG-----EVDL 823
GS PGSQ+GS ER RVR++SKSEGSP E A KPE+ +++ RP +PA + DL
Sbjct: 745 GSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDL 804
Query: 824 TALAKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAA 880
TALAKELR + E RP KVTDYSSSSEES +++EE++D E E D + + + R
Sbjct: 805 TALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLI 864
Query: 881 SSLNLSNGETESVKTMIVHDDVESEP---AMTPSKEGTLIVRQT--------QSASSTLQ 929
+ + E +V + H S + + S+EGTL++R+T S S+
Sbjct: 865 PTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFA 924
Query: 930 KH-----------------------------------------KSSSSFTPFIDPRLLQI 948
H + +SFTPF+DPR+ Q
Sbjct: 925 GHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQT 984
Query: 949 SPS----SGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKK 1004
SP+ ++ F+ + +R E + + RK SVVNVNPTN RP SDTPEIRKYKK
Sbjct: 985 SPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKK 1044
Query: 1005 RFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTIS 1064
RFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLEGLNVLVTIS
Sbjct: 1045 RFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTIS 1104
Query: 1065 GKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKS 1124
GKK+KLRVYYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERIKFLVIALK+
Sbjct: 1105 GKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKN 1164
Query: 1125 SVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGS 1184
+VE+YAWAPKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS GFH +DVDSG+
Sbjct: 1165 AVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGN 1224
Query: 1185 VYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPT 1244
YDIY+P+HIQ +I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRITKDVVLQWGEMPT
Sbjct: 1225 SYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPT 1284
Query: 1245 SVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS 1304
SVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS
Sbjct: 1285 SVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS 1344
Query: 1305 SQVYFMTLGRTSLLSW 1320
SQV+FMTL R S+++W
Sbjct: 1345 SQVFFMTLNRNSMMNW 1360
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 1644 bits (4256), Expect = 0.0
Identities = 894/1383 (64%), Positives = 1022/1383 (73%), Gaps = 149/1383 (10%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
+QQEREQRR +E+ RR EEE+RR E EQEYIRRQLEEEQR LE
Sbjct: 417 KQQEREQRRHYEEQMRR-----------------EEERRRAEHEQEYIRRQLEEEQRQLE 459
Query: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540
+LQQQLL EQA+LLE + +++EE RQAERLQRQL+QE+ YL+SLQH + P
Sbjct: 460 ILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRP------- 512
Query: 541 PPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRS 600
KP +H E + E A+E+ V +S
Sbjct: 513 ----VEKKPLYHYKEGMSPSEKPAWAKEIPHL-----------------------VAVKS 545
Query: 601 ESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQD 660
+ + S+SVH ++P + + ++ ++ + R + SDP+ S++
Sbjct: 546 QGPALTASQSVH---EQPTKGLSGFQEALNVTSHRVEMPRQN--SDPT---------SEN 591
Query: 661 PCPPSRSEVLSQSSDSKSEAPDPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRDSPLQG 720
P P+R E +SS W R + D +PP+VP RTTS SP L+R++SP G
Sbjct: 592 PPLPTRIEKFDRSS-------------WLRQEED-IPPKVPQRTTSISPALARKNSPGNG 637
Query: 721 SGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP----GSHPGSQS 776
S Q S+ + R +E + R SGSSS SS SQP GS PGSQ+
Sbjct: 638 SALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQA 697
Query: 777 GSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAV--- 833
GS ER RVR++SKSEGSP E A KPE+ +++ RP +PA DLTALAKELR +
Sbjct: 698 GSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA---DLTALAKELRELRIE 754
Query: 834 EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESV 893
E RP KVTDYSSSSEES +++EE++D E E D + + + R + + E +V
Sbjct: 755 ETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNV 814
Query: 894 KTMIVHDDVESEP---AMTPSKEGTLIVRQT--------QSASSTLQKH----------- 931
+ H S + + S+EGTL++R+T S S+ H
Sbjct: 815 GMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSH 874
Query: 932 ------------------------------KSSSSFTPFIDPRLLQISPS----SGTTVT 957
+ +SFTPF+DPR+ Q SP+ +
Sbjct: 875 SPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESS 934
Query: 958 SVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWG 1017
+ F+ + +R E + + RK SVVNVNPTN RP SDTPEIRKYKKRFNSEILCAALWG
Sbjct: 935 AAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWG 994
Query: 1018 VNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSW 1077
VNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLEGLNVLVTISGKK+KLRVYYLSW
Sbjct: 995 VNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSW 1054
Query: 1078 LRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYH 1137
LRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERIKFLVIALK++VE+YAWAPKPYH
Sbjct: 1055 LRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYH 1114
Query: 1138 KFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCS 1197
KFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS GFH +DVDSG+ YDIY+P+HIQ +
Sbjct: 1115 KFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGN 1174
Query: 1198 IKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGW 1257
I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI SNQ MGW
Sbjct: 1175 ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGW 1234
Query: 1258 GEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSL 1317
GEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTL R S+
Sbjct: 1235 GEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSM 1294
Query: 1318 LSW 1320
++W
Sbjct: 1295 MNW 1297
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 1643 bits (4254), Expect = 0.0
Identities = 894/1388 (64%), Positives = 1023/1388 (73%), Gaps = 151/1388 (10%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
+QQEREQRR +E+ RR EEE+RR E EQEYIRRQLEEEQR LE
Sbjct: 417 KQQEREQRRHYEEQMRR-----------------EEERRRAEHEQEYIRRQLEEEQRQLE 459
Query: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540
+LQQQLL EQA+LLE + +++EE RQAERLQRQL+QE+ YL+SLQH + P
Sbjct: 460 ILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRP------- 512
Query: 541 PPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRS 600
KP +H E + E A+E+ V +S
Sbjct: 513 ----VEKKPLYHYKEGMSPSEKPAWAKEIPHL-----------------------VAVKS 545
Query: 601 ESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQD 660
+ + S+SVH ++P + + ++ ++ + R + SDP+ S++
Sbjct: 546 QGPALTASQSVH---EQPTKGLSGFQEALNVTSHRVEMPRQN--SDPT---------SEN 591
Query: 661 PCPPSRSEVLSQSSDSKSEAPDPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRDSPLQG 720
P P+R E +SS W R + D +PP+VP RTTS SP L+R++SP G
Sbjct: 592 PPLPTRIEKFDRSS-------------WLRQEED-IPPKVPQRTTSISPALARKNSPGNG 637
Query: 721 SGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP----GSHPGSQS 776
S Q S+ + R +E + R SGSSS SS SQP GS PGSQ+
Sbjct: 638 SALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQA 697
Query: 777 GSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAG-----EVDLTALAKELR 831
GS ER RVR++SKSEGSP E A KPE+ +++ RP +PA + DLTALAKELR
Sbjct: 698 GSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELR 757
Query: 832 AV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNG 888
+ E RP KVTDYSSSSEES +++EE++D E E D + + + R + +
Sbjct: 758 ELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSN 817
Query: 889 ETESVKTMIVHDDVESEP---AMTPSKEGTLIVRQT--------QSASSTLQKH------ 931
E +V + H S + + S+EGTL++R+T S S+ H
Sbjct: 818 EQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDL 877
Query: 932 -----------------------------------KSSSSFTPFIDPRLLQISPS----S 952
+ +SFTPF+DPR+ Q SP+
Sbjct: 878 VQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEE 937
Query: 953 GTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILC 1012
++ F+ + +R E + + RK SVVNVNPTN RP SDTPEIRKYKKRFNSEILC
Sbjct: 938 DEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILC 997
Query: 1013 AALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRV 1072
AALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLEGLNVLVTISGKK+KLRV
Sbjct: 998 AALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRV 1057
Query: 1073 YYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWA 1132
YYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERIKFLVIALK++VE+YAWA
Sbjct: 1058 YYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWA 1117
Query: 1133 PKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPT 1192
PKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS GFH +DVDSG+ YDIY+P+
Sbjct: 1118 PKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPS 1177
Query: 1193 HIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSN 1252
HIQ +I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI SN
Sbjct: 1178 HIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSN 1237
Query: 1253 QTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTL 1312
Q MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTL
Sbjct: 1238 QIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTL 1297
Query: 1313 GRTSLLSW 1320
R S+++W
Sbjct: 1298 NRNSMMNW 1305
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 1637 bits (4240), Expect = 0.0
Identities = 893/1391 (64%), Positives = 1018/1391 (73%), Gaps = 139/1391 (9%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
+QQEREQ R+ EE+ R EEE+RR E EQEY R+QLEE+
Sbjct: 417 KQQEREQ-----------------RRHYEEQMRREEERRRAEHEQEYKRKQLEEQ----- 454
Query: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540
RQAERLQRQL+QE+ YL+SLQH + P
Sbjct: 455 ------------------------RQAERLQRQLKQERDYLVSLQHQRQEQRPVEK---- 486
Query: 541 PPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRS 600
KP +H E + E A+EVE+R R SSP K R+ +P +P RS
Sbjct: 487 -------KPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRS 539
Query: 601 ESFS-NGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQ 659
ESFS +G + P + RP +PQ+ HL ++K+ ++ S S + K +
Sbjct: 540 ESFSISGVQPARTPPMLRPVDPQIP--HLVAVKSQGPALTASQSVHEQPTKGLSGFQEAL 597
Query: 660 DPCPPSRSEVLSQSSDSKSEAPD-PTQ------KAWSRSDSDEVPPRVPVRTTSRSPVLS 712
+ R E+ Q+SD SE P PT+ +W R + D +PP+VP RTTS SP L+
Sbjct: 598 N-VTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEED-IPPKVPQRTTSISPALA 655
Query: 713 RRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP---- 768
R++SP GS Q S+ + R +E + R SGSSS SS SQP
Sbjct: 656 RKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQG 715
Query: 769 GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAK 828
GS PGSQ+GS ER RVR++SKSEGSP E A KPE+ +++ RP +PA DLTALAK
Sbjct: 716 GSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA---DLTALAK 772
Query: 829 ELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNL 885
ELR + E RP KVTDYSSSSEES +++EE++D E E D + + + R +
Sbjct: 773 ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP 832
Query: 886 SNGETESVKTMIVHDDVESEP---AMTPSKEGTLIVRQT--------QSASSTLQKH--- 931
+ E +V + H S + + S+EGTL++R+T S S+ H
Sbjct: 833 GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINL 892
Query: 932 --------------------------------------KSSSSFTPFIDPRLLQISPS-- 951
+ +SFTPF+DPR+ Q SP+
Sbjct: 893 PDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDE 952
Query: 952 --SGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSE 1009
++ F+ + +R E + + RK SVVNVNPTN RP SDTPEIRKYKKRFNSE
Sbjct: 953 DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE 1012
Query: 1010 ILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDK 1069
ILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLEGLNVLVTISGKK+K
Sbjct: 1013 ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK 1072
Query: 1070 LRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVY 1129
LRVYYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERIKFLVIALK++VE+Y
Sbjct: 1073 LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY 1132
Query: 1130 AWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIY 1189
AWAPKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS GFH +DVDSG+ YDIY
Sbjct: 1133 AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY 1192
Query: 1190 LPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI 1249
+P+HIQ +I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI
Sbjct: 1193 IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI 1252
Query: 1250 RSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYF 1309
SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+F
Sbjct: 1253 HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF 1312
Query: 1310 MTLGRTSLLSW 1320
MTL R S+++W
Sbjct: 1313 MTLNRNSMMNW 1323
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 1637 bits (4238), Expect = 0.0
Identities = 893/1396 (63%), Positives = 1019/1396 (72%), Gaps = 141/1396 (10%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
+QQEREQ R+ EE+ R EEE+RR E EQEY R+QLEE+
Sbjct: 417 KQQEREQ-----------------RRHYEEQMRREEERRRAEHEQEYKRKQLEEQ----- 454
Query: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540
RQAERLQRQL+QE+ YL+SLQH + P
Sbjct: 455 ------------------------RQAERLQRQLKQERDYLVSLQHQRQEQRPVEK---- 486
Query: 541 PPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRS 600
KP +H E + E A+EVE+R R SSP K R+ +P +P RS
Sbjct: 487 -------KPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRS 539
Query: 601 ESFS-NGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQ 659
ESFS +G + P + RP +PQ+ HL ++K+ ++ S S + K +
Sbjct: 540 ESFSISGVQPARTPPMLRPVDPQIP--HLVAVKSQGPALTASQSVHEQPTKGLSGFQEAL 597
Query: 660 DPCPPSRSEVLSQSSDSKSEAPD-PTQ------KAWSRSDSDEVPPRVPVRTTSRSPVLS 712
+ R E+ Q+SD SE P PT+ +W R + D +PP+VP RTTS SP L+
Sbjct: 598 N-VTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEED-IPPKVPQRTTSISPALA 655
Query: 713 RRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP---- 768
R++SP GS Q S+ + R +E + R SGSSS SS SQP
Sbjct: 656 RKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQG 715
Query: 769 GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAG-----EVDL 823
GS PGSQ+GS ER RVR++SKSEGSP E A KPE+ +++ RP +PA + DL
Sbjct: 716 GSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDL 775
Query: 824 TALAKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAA 880
TALAKELR + E RP KVTDYSSSSEES +++EE++D E E D + + + R
Sbjct: 776 TALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLI 835
Query: 881 SSLNLSNGETESVKTMIVHDDVESEP---AMTPSKEGTLIVRQT--------QSASSTLQ 929
+ + E +V + H S + + S+EGTL++R+T S S+
Sbjct: 836 PTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFA 895
Query: 930 KH-----------------------------------------KSSSSFTPFIDPRLLQI 948
H + +SFTPF+DPR+ Q
Sbjct: 896 GHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQT 955
Query: 949 SPS----SGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKK 1004
SP+ ++ F+ + +R E + + RK SVVNVNPTN RP SDTPEIRKYKK
Sbjct: 956 SPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKK 1015
Query: 1005 RFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTIS 1064
RFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLEGLNVLVTIS
Sbjct: 1016 RFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTIS 1075
Query: 1065 GKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKS 1124
GKK+KLRVYYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERIKFLVIALK+
Sbjct: 1076 GKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKN 1135
Query: 1125 SVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGS 1184
+VE+YAWAPKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS GFH +DVDSG+
Sbjct: 1136 AVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGN 1195
Query: 1185 VYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPT 1244
YDIY+P+HIQ +I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRITKDVVLQWGEMPT
Sbjct: 1196 SYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPT 1255
Query: 1245 SVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS 1304
SVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS
Sbjct: 1256 SVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS 1315
Query: 1305 SQVYFMTLGRTSLLSW 1320
SQV+FMTL R S+++W
Sbjct: 1316 SQVFFMTLNRNSMMNW 1331
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 1576 bits (4082), Expect = 0.0
Identities = 870/1383 (62%), Positives = 994/1383 (71%), Gaps = 178/1383 (12%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
+QQEREQRR +E+ RR EEE+RR E EQEY R+QL EEQR E
Sbjct: 417 KQQEREQRRHYEEQMRR-----------------EEERRRAEHEQEYKRKQL-EEQRQAE 458
Query: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540
LQ+Q L+QE+ YL+SLQH + P
Sbjct: 459 RLQRQ----------------------------LKQERDYLVSLQHQRQEQRP------- 483
Query: 541 PPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRS 600
KP +H E + E A+E+ V +S
Sbjct: 484 ----VEKKPLYHYKEGMSPSEKPAWAKEIPHL-----------------------VAVKS 516
Query: 601 ESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQD 660
+ + S+SVH ++P + + ++ ++ + R + SDP+ S++
Sbjct: 517 QGPALTASQSVH---EQPTKGLSGFQEALNVTSHRVEMPRQN--SDPT---------SEN 562
Query: 661 PCPPSRSEVLSQSSDSKSEAPDPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRDSPLQG 720
P P+R E +SS W R + D +PP+VP RTTS SP L+R++SP G
Sbjct: 563 PPLPTRIEKFDRSS-------------WLRQEED-IPPKVPQRTTSISPALARKNSPGNG 608
Query: 721 SGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP----GSHPGSQS 776
S Q S+ + R +E + R SGSSS SS SQP GS PGSQ+
Sbjct: 609 SALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQA 668
Query: 777 GSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAV--- 833
GS ER RVR++SKSEGSP E A KPE+ +++ RP +PA DLTALAKELR +
Sbjct: 669 GSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA---DLTALAKELRELRIE 725
Query: 834 EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESV 893
E RP KVTDYSSSSEES +++EE++D E E D + + + R + + E +V
Sbjct: 726 ETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNV 785
Query: 894 KTMIVHDDVESEP---AMTPSKEGTLIVRQT--------QSASSTLQKH----------- 931
+ H S + + S+EGTL++R+T S S+ H
Sbjct: 786 GMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSH 845
Query: 932 ------------------------------KSSSSFTPFIDPRLLQISPS----SGTTVT 957
+ +SFTPF+DPR+ Q SP+ +
Sbjct: 846 SPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESS 905
Query: 958 SVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWG 1017
+ F+ + +R E + + RK SVVNVNPTN RP SDTPEIRKYKKRFNSEILCAALWG
Sbjct: 906 AAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWG 965
Query: 1018 VNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSW 1077
VNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLEGLNVLVTISGKK+KLRVYYLSW
Sbjct: 966 VNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSW 1025
Query: 1078 LRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYH 1137
LRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERIKFLVIALK++VE+YAWAPKPYH
Sbjct: 1026 LRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYH 1085
Query: 1138 KFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCS 1197
KFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS GFH +DVDSG+ YDIY+P+HIQ +
Sbjct: 1086 KFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGN 1145
Query: 1198 IKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGW 1257
I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI SNQ MGW
Sbjct: 1146 ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGW 1205
Query: 1258 GEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSL 1317
GEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTL R S+
Sbjct: 1206 GEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSM 1265
Query: 1318 LSW 1320
++W
Sbjct: 1266 MNW 1268
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 1576 bits (4080), Expect = 0.0
Identities = 870/1388 (62%), Positives = 995/1388 (71%), Gaps = 180/1388 (12%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
+QQEREQRR +E+ RR EEE+RR E EQEY R+QL EEQR E
Sbjct: 417 KQQEREQRRHYEEQMRR-----------------EEERRRAEHEQEYKRKQL-EEQRQAE 458
Query: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540
LQ+Q L+QE+ YL+SLQH + P
Sbjct: 459 RLQRQ----------------------------LKQERDYLVSLQHQRQEQRP------- 483
Query: 541 PPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRS 600
KP +H E + E A+E+ V +S
Sbjct: 484 ----VEKKPLYHYKEGMSPSEKPAWAKEIPHL-----------------------VAVKS 516
Query: 601 ESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQD 660
+ + S+SVH ++P + + ++ ++ + R + SDP+ S++
Sbjct: 517 QGPALTASQSVH---EQPTKGLSGFQEALNVTSHRVEMPRQN--SDPT---------SEN 562
Query: 661 PCPPSRSEVLSQSSDSKSEAPDPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRDSPLQG 720
P P+R E +SS W R + D +PP+VP RTTS SP L+R++SP G
Sbjct: 563 PPLPTRIEKFDRSS-------------WLRQEED-IPPKVPQRTTSISPALARKNSPGNG 608
Query: 721 SGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP----GSHPGSQS 776
S Q S+ + R +E + R SGSSS SS SQP GS PGSQ+
Sbjct: 609 SALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQA 668
Query: 777 GSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAG-----EVDLTALAKELR 831
GS ER RVR++SKSEGSP E A KPE+ +++ RP +PA + DLTALAKELR
Sbjct: 669 GSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELR 728
Query: 832 AV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNG 888
+ E RP KVTDYSSSSEES +++EE++D E E D + + + R + +
Sbjct: 729 ELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSN 788
Query: 889 ETESVKTMIVHDDVESEP---AMTPSKEGTLIVRQT--------QSASSTLQKH------ 931
E +V + H S + + S+EGTL++R+T S S+ H
Sbjct: 789 EQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDL 848
Query: 932 -----------------------------------KSSSSFTPFIDPRLLQISPS----S 952
+ +SFTPF+DPR+ Q SP+
Sbjct: 849 VQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEE 908
Query: 953 GTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILC 1012
++ F+ + +R E + + RK SVVNVNPTN RP SDTPEIRKYKKRFNSEILC
Sbjct: 909 DEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILC 968
Query: 1013 AALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRV 1072
AALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLEGLNVLVTISGKK+KLRV
Sbjct: 969 AALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRV 1028
Query: 1073 YYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWA 1132
YYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERIKFLVIALK++VE+YAWA
Sbjct: 1029 YYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWA 1088
Query: 1133 PKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPT 1192
PKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS GFH +DVDSG+ YDIY+P+
Sbjct: 1089 PKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPS 1148
Query: 1193 HIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSN 1252
HIQ +I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI SN
Sbjct: 1149 HIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSN 1208
Query: 1253 QTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTL 1312
Q MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTL
Sbjct: 1209 QIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTL 1268
Query: 1313 GRTSLLSW 1320
R S+++W
Sbjct: 1269 NRNSMMNW 1276
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 1552 bits (4018), Expect = 0.0
Identities = 874/1406 (62%), Positives = 989/1406 (70%), Gaps = 160/1406 (11%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M + +PA+SL DIDLS+LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKKSPPG+DDQLWLVMEFCGAGS+TDLVKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKED IAYI REILRGLAHLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSD+WS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNPPPRLKSKKWSKKF FI+ CL+K Y+ RP TEQLLK PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDR+RKKRGEK+ETEYEYSGSEEE++ E EGEPSSI+NVPGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNVPGESTLRREFLRLQ 359
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
QENK SEAL++QQ LQ+QQ R+ E + + LL +RQ+RIE+QKE+RRR+EEQQRRERE R
Sbjct: 360 QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
+ QE+EQ+ RRLE+++ R+EEE +R+ EREQEY R+QLEE+
Sbjct: 420 KLQEKEQQ-------RRLEDMQALRREEE--------RRQAEREQEYKRKQLEEQ----- 459
Query: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540
RQ+ERLQRQLQQE AYL SLQ ++ Q QQ
Sbjct: 460 ------------------------RQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQ 495
Query: 541 PPQQERSKPSFHAPEPKAHYEPADR---AREVEDRFRKTNH-SSPEAQSKQTGRVLEPPV 596
+R KP +H PAD+ AREVE+R R +SP A+SK EPP+
Sbjct: 496 LLPGDR-KPLYHYGRGM---NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPI 551
Query: 597 PSRSESFSNGNSESVHPALQRPAEPQVQ-----WSHLASLKNNVSPVSRSHSFSDPSPKF 651
P S S++ P +QRP EPQ +H LK +PV RS S D +
Sbjct: 552 PQASPGPPGPLSQT--PPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRN 609
Query: 652 AHHHLRSQDP---------CPPSRSEVLSQSSDSKSEAPDPTQK--AWSRSDSDEVPPRV 700
S DP P +R V+ Q+SD SE P P+ AW R D+ E PP+V
Sbjct: 610 LAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDN-EAPPKV 668
Query: 701 PVRTTSRSPVLSRRDSPLQGSGQQNSQAGQ-RNSTSSIEPRLLWERVEKLVPRPGSGSSS 759
P RT+S + L+ + G + +QA + R ++S L R E+ P+P +
Sbjct: 669 PQRTSSIATALNTSGA----GGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQ 724
Query: 760 --GSSNSGSQPG---SHPG---------------SQSGSGERFRVRSSSKSEGSPSQRLE 799
G N+ S P S PG Q+GS ER RV SSK + SP
Sbjct: 725 PPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPVLSPG 784
Query: 800 NAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEED 859
N K P+D + RP +PA V L KE E RPP K DYSSSSEE E
Sbjct: 785 NKAK-PDDHRS--RPGRPADFV----LLKERTLDEAPRPPKKAMDYSSSSEEV----ESS 833
Query: 860 DDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVR 919
+D E+EG G DT S +G+T+SV TM+VHD E P GT++V+
Sbjct: 834 EDDEEEGEGGPAEGSRDTPGGRS----DGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQ 889
Query: 920 QTQSA--------------------------------------------SSTLQKHKSSS 935
+T S L K S
Sbjct: 890 RTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKS 949
Query: 936 SFTPFIDPRLLQISPSSGTT-VTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQS 994
SFT F+D + Q S + +T++VG +G R + ++ D RKGSVVNVNPTNTR S
Sbjct: 950 SFTMFVDLGIYQPGGSGDSIPITALVGG--EGTRLDQLQYD-VRKGSVVNVNPTNTRAHS 1006
Query: 995 DTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVL 1054
+TPEIRKYKKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LI RRRFQQMDVL
Sbjct: 1007 ETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVL 1066
Query: 1055 EGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYER 1114
EGLN+L+TISGK++KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGD+EGC HY+VVKYER
Sbjct: 1067 EGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYER 1126
Query: 1115 IKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAG 1174
IKFLVIALKSSVEVYAWAPKPYHKFMAFKSF +L H+PLLVDLTVEEGQRLKVIYGS AG
Sbjct: 1127 IKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAG 1186
Query: 1175 FHAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKD 1234
FHAVDVDSG+ YDIY+P HIQ I PHAII LPNTDGME+L+CYEDEGVYVNTYGRI KD
Sbjct: 1187 FHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKD 1246
Query: 1235 VVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV 1294
VVLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV
Sbjct: 1247 VVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV 1306
Query: 1295 FFASVRSGGSSQVYFMTLGRTSLLSW 1320
FFASVRSGGSSQVYFMTL R +++W
Sbjct: 1307 FFASVRSGGSSQVYFMTLNRNCIMNW 1332
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 1550 bits (4014), Expect = 0.0
Identities = 866/1385 (62%), Positives = 982/1385 (70%), Gaps = 155/1385 (11%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M + +PA+SL DIDLS+LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKKSPPG+DDQLWLVMEFCGAGS+TDLVKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKED IAYI REILRGLAHLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSD+WS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNPPPRLKSKKWSKKF FI+ CL+K Y+ RP TEQLLK PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDR+RKKRGEK+ETEYEYSGSEEE++ E EGEPSSI+NVPGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNVPGESTLRREFLRLQ 359
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
QENK SEAL++QQ LQ+QQ R+ E + + LL +RQ+RIE+QKE+RRR+EEQQRRERE R
Sbjct: 360 QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
+ QE+EQ+ RRLE+++ R+EEE +R+ EREQEY R+QLEE+
Sbjct: 420 KLQEKEQQ-------RRLEDMQALRREEE--------RRQAEREQEYKRKQLEEQ----- 459
Query: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540
RQ+ERLQRQLQQE AYL SLQ ++ Q QQ
Sbjct: 460 ------------------------RQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQ 495
Query: 541 PPQQERSKPSFHAPEPKAHYEPADR---AREVEDRFRKTNH-SSPEAQSKQTGRVLEPPV 596
+R KP +H PAD+ AREVE+R R +SP A+SK EPP+
Sbjct: 496 LLPGDR-KPLYHYGRGM---NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPI 551
Query: 597 PSRSESFSNGNSESVHPALQRPAEPQVQ-----WSHLASLKNNVSPVSRSHSFSDPSPKF 651
P S S++ P +QRP EPQ +H LK +PV RS S D +
Sbjct: 552 PQASPGPPGPLSQT--PPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRN 609
Query: 652 AHHHLRSQDP---------CPPSRSEVLSQSSDSKSEAPDPTQK--AWSRSDSDEVPPRV 700
S DP P +R V+ Q+SD SE P P+ AW R D+ E PP+V
Sbjct: 610 LAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDN-EAPPKV 668
Query: 701 PVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSG 760
P RT+S + L+ + G + +QA + ++ WER + ++P
Sbjct: 669 PQRTSSIATALNTSGA----GGSRPAQAVRASNPDLRRSDPGWERSDSVLP--------- 715
Query: 761 SSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGE 820
++ G P Q+GS ER RV SSK + SP N K P+D + RP +PA
Sbjct: 716 -ASHGHLP------QAGSLERNRVGVSSKPDSSPVLSPGNKAK-PDDHRS--RPGRPADF 765
Query: 821 VDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAA 880
V L KE E RPP K DYSSSSEE E +D E+EG G DT
Sbjct: 766 V----LLKERTLDEAPRPPKKAMDYSSSSEEV----ESSEDDEEEGEGGPAEGSRDTPGG 817
Query: 881 SSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSA---------------- 924
S +G+T+SV TM+VHD E P GT++V++T
Sbjct: 818 RS----DGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLP 873
Query: 925 ----------------------------SSTLQKHKSSSSFTPFIDPRLLQISPSSGTT- 955
S L K SSFT F+D + Q S +
Sbjct: 874 DVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIP 933
Query: 956 VTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAAL 1015
+T++VG +G R + ++ D RKGSVVNVNPTNTR S+TPEIRKYKKRFNSEILCAAL
Sbjct: 934 ITALVGG--EGTRLDQLQYD-VRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAAL 990
Query: 1016 WGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYL 1075
WGVNLLVGTE+GLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK++KLRVYYL
Sbjct: 991 WGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYL 1050
Query: 1076 SWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKP 1135
SWLRNKILHNDPEVEKKQGWTTVGD+EGC HY+VVKYERIKFLVIALKSSVEVYAWAPKP
Sbjct: 1051 SWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKP 1110
Query: 1136 YHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQ 1195
YHKFMAFKSF +L H+PLLVDLTVEEGQRLKVIYGS AGFHAVDVDSG+ YDIY+P HIQ
Sbjct: 1111 YHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQ 1170
Query: 1196 CSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTM 1255
I PHAII LPNTDGME+L+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQ M
Sbjct: 1171 SQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIM 1230
Query: 1256 GWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRT 1315
GWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTL R
Sbjct: 1231 GWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRN 1290
Query: 1316 SLLSW 1320
+++W
Sbjct: 1291 CIMNW 1295
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 1547 bits (4006), Expect = 0.0
Identities = 865/1389 (62%), Positives = 981/1389 (70%), Gaps = 155/1389 (11%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M + +PA+SL DIDLS+LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKKSPPG+DDQLWLVMEFCGAGS+TDLVKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKED IAYI REILRGLAHLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSD+WS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNPPPRLKSKKWSKKF FI+ CL+K Y+ RP TEQLLK PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDR+RKKRGEK+ETEYEYSGSEEE++ E EGEPSSI+NVPGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNVPGESTLRREFLRLQ 359
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
QENK SEAL++QQ LQ+QQ R+ E + + LL +RQ+RIE+QKE+RRR+EEQQRRERE R
Sbjct: 360 QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
+ QE+EQ+ RRLE+++ R+EEE +R+ EREQEY R+QLEE+
Sbjct: 420 KLQEKEQQ-------RRLEDMQALRREEE--------RRQAEREQEYKRKQLEEQ----- 459
Query: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540
RQ+ERLQRQLQQE AYL SLQ ++ Q QQ
Sbjct: 460 ------------------------RQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQ 495
Query: 541 PPQQERSKPSFHAPEPKAHYEPADR---AREVEDRFRKTNH-SSPEAQSKQTGRVLEPPV 596
+R KP +H PAD+ AREVE+R R +SP A+SK EPP+
Sbjct: 496 LLPGDR-KPLYHYGRGM---NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPI 551
Query: 597 PSRSESFSNGNSESVHPALQRPAEPQVQ-----WSHLASLKNNVSPVSRSHSFSDPSPKF 651
P S S++ P +QRP EPQ +H LK +PV RS S D +
Sbjct: 552 PQASPGPPGPLSQT--PPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRN 609
Query: 652 AHHHLRSQDP---------CPPSRSEVLSQSSDSKSEAPDPTQK--AWSRSDSDEVPPRV 700
S DP P +R V+ Q+SD SE P P+ AW R D+ E PP+V
Sbjct: 610 LAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDN-EAPPKV 668
Query: 701 PVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSG 760
P RT+S + L+ + G + +QA + ++ WER + ++P
Sbjct: 669 PQRTSSIATALNTSGA----GGSRPAQAVRASNPDLRRSDPGWERSDSVLP--------- 715
Query: 761 SSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGE 820
++ G P Q+GS ER RV SSK + SP N K P+D + RP +PA
Sbjct: 716 -ASHGHLP------QAGSLERNRVGVSSKPDSSPVLSPGNKAK-PDDHRS--RPGRPASY 765
Query: 821 VDLTA----LAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPED 876
L KE E RPP K DYSSSSEE E +D E+EG G D
Sbjct: 766 KRAIGEDFVLLKERTLDEAPRPPKKAMDYSSSSEEV----ESSEDDEEEGEGGPAEGSRD 821
Query: 877 TRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSA------------ 924
T S +G+T+SV TM+VHD E P GT++V++T
Sbjct: 822 TPGGRS----DGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGY 877
Query: 925 --------------------------------SSTLQKHKSSSSFTPFIDPRLLQISPSS 952
S L K SSFT F+D + Q S
Sbjct: 878 TNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSG 937
Query: 953 GTT-VTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEIL 1011
+ +T++VG +G R + ++ D RKGSVVNVNPTNTR S+TPEIRKYKKRFNSEIL
Sbjct: 938 DSIPITALVGG--EGTRLDQLQYD-VRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEIL 994
Query: 1012 CAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLR 1071
CAALWGVNLLVGTE+GLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK++KLR
Sbjct: 995 CAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLR 1054
Query: 1072 VYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAW 1131
VYYLSWLRNKILHNDPEVEKKQGWTTVGD+EGC HY+VVKYERIKFLVIALKSSVEVYAW
Sbjct: 1055 VYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAW 1114
Query: 1132 APKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLP 1191
APKPYHKFMAFKSF +L H+PLLVDLTVEEGQRLKVIYGS AGFHAVDVDSG+ YDIY+P
Sbjct: 1115 APKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIP 1174
Query: 1192 THIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRS 1251
HIQ I PHAII LPNTDGME+L+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI S
Sbjct: 1175 VHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICS 1234
Query: 1252 NQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMT 1311
NQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMT
Sbjct: 1235 NQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMT 1294
Query: 1312 LGRTSLLSW 1320
L R +++W
Sbjct: 1295 LNRNCIMNW 1303
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 1544 bits (3997), Expect = 0.0
Identities = 866/1392 (62%), Positives = 985/1392 (70%), Gaps = 152/1392 (10%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M + +PA+SL DIDLS+LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKKSPPG+DDQLWLVMEFCGAGS+TDLVKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKED IAYI REILRGLAHLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSD+WS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNPPPRLKSKKWSKKF FI+ CL+K Y+ RP TEQLLK PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDR+RKKRGEK+ETEYEYSGSEEE++ E EGEPSSI+NVPGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNVPGESTLRREFLRLQ 359
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
QENK SEAL++QQ LQ+QQ R+ E + + LL +RQ+RIE+QKE+RRR+EEQQRRERE R
Sbjct: 360 QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
+ QE+EQ+ RRLE+++ R+EEE +R+ EREQEY R+QLEE+
Sbjct: 420 KLQEKEQQ-------RRLEDMQALRREEE--------RRQAEREQEYKRKQLEEQ----- 459
Query: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540
RQ+ERLQRQLQQE AYL SLQ ++ Q QQ
Sbjct: 460 ------------------------RQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQ 495
Query: 541 PPQQERSKPSFHAPEPKAHYEPADR---AREVEDRFRKTNH-SSPEAQSKQTGRVLEPPV 596
+R KP +H PAD+ AREVE+R R +SP A+SK EPP+
Sbjct: 496 LLPGDR-KPLYHYGRGM---NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPI 551
Query: 597 PSRSESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHL 656
P S S++ P +QRP EPQ + H + ++ + DP P +
Sbjct: 552 PQASPGPPGPLSQT--PPMQRPVEPQ-EGPHKSLQDQPTRNLAAFPASHDPDPA-----I 603
Query: 657 RSQDPCPPSRSEVLSQSSDSKSEAPDPTQK--AWSRSDSDEVPPRVPVRTTSRSPVLSRR 714
+ P +R V+ Q+SD SE P P+ AW R D+ E PP+VP RT+S + L+
Sbjct: 604 PAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDN-EAPPKVPQRTSSIATALNTS 662
Query: 715 DSPLQGSGQQNSQAGQ-RNSTSSIEPRLLWERVEKLVPRPGSGSSS--GSSNSGSQPG-- 769
+ G + +QA + R ++S L R E+ P+P + G N+ S P
Sbjct: 663 GA----GGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLR 718
Query: 770 -SHPG---------------SQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFR 813
S PG Q+GS ER RV SSK + SP N K P+D + R
Sbjct: 719 RSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAK-PDDHRS--R 775
Query: 814 PLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSG 873
P +PA V L KE E RPP K DYSSSSEE E +D E+EG G
Sbjct: 776 PGRPADFV----LLKERTLDEAPRPPKKAMDYSSSSEEV----ESSEDDEEEGEGGPAEG 827
Query: 874 PEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSA--------- 924
DT S +G+T+SV TM+VHD E P GT++V++T
Sbjct: 828 SRDTPGGRS----DGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLHADS 883
Query: 925 -----------------------------------SSTLQKHKSSSSFTPFIDPRLLQIS 949
S L K SSFT F+D + Q
Sbjct: 884 NGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPG 943
Query: 950 PSSGTT-VTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNS 1008
S + +T++VG +G R + ++ D RKGSVVNVNPTNTR S+TPEIRKYKKRFNS
Sbjct: 944 GSGDSIPITALVGG--EGTRLDQLQYD-VRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS 1000
Query: 1009 EILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKD 1068
EILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK++
Sbjct: 1001 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN 1060
Query: 1069 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEV 1128
KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGD+EGC HY+VVKYERIKFLVIALKSSVEV
Sbjct: 1061 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV 1120
Query: 1129 YAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDI 1188
YAWAPKPYHKFMAFKSF +L H+PLLVDLTVEEGQRLKVIYGS AGFHAVDVDSG+ YDI
Sbjct: 1121 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI 1180
Query: 1189 YLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAY 1248
Y+P HIQ I PHAII LPNTDGME+L+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAY
Sbjct: 1181 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY 1240
Query: 1249 IRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1308
I SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY
Sbjct: 1241 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1300
Query: 1309 FMTLGRTSLLSW 1320
FMTL R +++W
Sbjct: 1301 FMTLNRNCIMNW 1312
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 1267 bits (3279), Expect = 0.0
Identities = 684/928 (73%), Positives = 731/928 (78%), Gaps = 73/928 (7%)
Query: 413 QRREREARRQ-QEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKR---------RVE 462
Q ER+ R Q ++ R R++ ++ E E EEEE E+E
Sbjct: 292 QPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGEST 351
Query: 463 REQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLL 522
++++R Q E ++R + +QQLLQEQ + RE EE+++ +RQ + EQ
Sbjct: 352 LRRDFLRLQQENKERSEALRRQQLLQEQQL------REQEEYKRQLLAERQKRIEQQ--- 402
Query: 523 SLQHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPE 582
+ RR Q ++ +Q+ + E K E +R R+ E+ R+
Sbjct: 403 --KEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRR 460
Query: 583 AQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNV--SPVSR 640
+ +Q ++R E + + HL L+ +
Sbjct: 461 VEREQE-------------------------YIRRQLEEEQR--HLEVLQQQLLQEQAML 493
Query: 641 SHSFSDPSPKFAHHHLRSQDPCPPSRSEVLSQSSDSKSEAPDPTQKAWSRSDSDEVPPRV 700
H P P+ SQ P PP + + S AP+P + + + V
Sbjct: 494 LHDHRRPHPQ------HSQQPPPPQQ-----ERSKPSFHAPEPK----AHYEPADRAREV 538
Query: 701 PVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSG 760
PVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSG
Sbjct: 539 PVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSG 598
Query: 761 SSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGE 820
SSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGE
Sbjct: 599 SSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGE 658
Query: 821 VDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAA 880
VDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAA
Sbjct: 659 VDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAA 718
Query: 881 SSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPF 940
SSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPF
Sbjct: 719 SSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPF 778
Query: 941 IDPRLLQISPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIR 1000
IDPRLLQISPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIR
Sbjct: 779 IDPRLLQISPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIR 838
Query: 1001 KYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVL 1060
KYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVL
Sbjct: 839 KYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVL 898
Query: 1061 VTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVI 1120
VTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVI
Sbjct: 899 VTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVI 958
Query: 1121 ALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDV 1180
ALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDV
Sbjct: 959 ALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDV 1018
Query: 1181 DSGSVYDIYLPTH--------IQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRIT 1232
DSGSVYDIYLPTH IQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRIT
Sbjct: 1019 DSGSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRIT 1078
Query: 1233 KDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERND 1292
KDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERND
Sbjct: 1079 KDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERND 1138
Query: 1293 KVFFASVRSGGSSQVYFMTLGRTSLLSW 1320
KVFFASVRSGGSSQVYFMTLGRTSLLSW
Sbjct: 1139 KVFFASVRSGGSSQVYFMTLGRTSLLSW 1166
Score = 1080 bits (2794), Expect = 0.0
Identities = 571/690 (82%), Positives = 581/690 (84%), Gaps = 59/690 (8%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE
Sbjct: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
Query: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540
VLQQQLLQEQAMLL HDHRRPHPQHSQQPP
Sbjct: 481 VLQQQLLQEQAMLL-------------------------------HDHRRPHPQHSQQPP 509
Query: 541 PPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRS 600
PPQQERSKPSFHAPEPKAHYEPADRAREV R T+ S PV SR
Sbjct: 510 PPQQERSKPSFHAPEPKAHYEPADRAREVP--VRTTSRS---------------PVLSRR 552
Query: 601 ESFSNGNSESVHPALQRPA----EPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHL 656
+S G+ + A QR + EP++ W + L P S S S S S H
Sbjct: 553 DSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPR--PGSGSSSGSSNSGSQPGSHP 610
Query: 657 RSQDPCPPSRSEVLSQSSDSKSEAPDPTQK 686
SQ E S SKSE P+Q+
Sbjct: 611 GSQS----GSGERFRVRSSSKSEG-SPSQR 635
>gi|118600963 Nik related kinase [Homo sapiens]
Length = 1582
Score = 419 bits (1077), Expect = e-117
Identities = 325/989 (32%), Positives = 468/989 (47%), Gaps = 132/989 (13%)
Query: 14 DLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE------------- 60
DL L DP GIF L + +G GTYG++Y G H KTG A+KVM+ +
Sbjct: 14 DLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVN 73
Query: 61 -----------DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCG 109
DEEE+++ E+N+L+KYS H+NI ++YGAF K SPPG QLW+VME C
Sbjct: 74 KYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCA 133
Query: 110 AGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKL 169
AGS+TD+V+ T +LKEDWIAYI REIL+GLAHLH H VIHRDIKGQNVLLT NAEVKL
Sbjct: 134 AGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKL 193
Query: 170 VDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEG 229
VDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P +YDYRSD+WS GITAIEMAEG
Sbjct: 194 VDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEG 253
Query: 230 APPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI 289
APPLC++ P+ ALF+I R P +KS WS+KF +F+E C +KN++ RP++ +L+HPF+
Sbjct: 254 APPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLFRPTSANMLQHPFV 313
Query: 290 RDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQ------------- 336
RD NER V L H+ KKR +K E EE + EQ
Sbjct: 314 RDIKNERHVVESLTRHLTGIIKKRQKKG-----IPLIFEREEAIKEQYTVRRFRGPSCTH 368
Query: 337 -----------------EGEPSSIVNVPGEST-----------LRRDFLRLQ------QE 362
GEPS +P R F+ LQ +
Sbjct: 369 ELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAARVFMPLQALDSAPKP 428
Query: 363 NKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR------LEEQQRRE 416
K +++A +R Q + Q + K + Q +I+ RR L+ Q R
Sbjct: 429 LKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAARVLMPLQAQVRAP 488
Query: 417 REARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQ 476
R + Q + ++++ Q + ++L++ +E + + + E++R+ + E++Q
Sbjct: 489 RLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQGQAP--------EQQQ 540
Query: 477 RHLEVLQQQLLQ----EQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPH 532
RH +V +Q+L Q EQ + E + +AE + Q +L L DH
Sbjct: 541 RHNQVPEQELEQNQAPEQPEVQEQAAEPAQAETEAEEPESLRVNAQVFLPLLSQDHHVLL 600
Query: 533 PQH-SQQPPPPQQERSKPSFHAPEPKA-HYEPADRAREVEDRFRKTNHSSPEAQSKQTGR 590
P H Q P + +++ S P+ +A EP V+ + A + +
Sbjct: 601 PLHLDTQVLIPVEGQTEGS---PQAQAWTLEPPQAIGSVQALIEGLSRDLLRAPNSNNSK 657
Query: 591 VLEPPVPSRSESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHS------- 643
L P+ + E+ S+ S P R + +V A K R+ S
Sbjct: 658 PL-GPLQTLMENLSSNRFYS-QPEQAREKKSKVSTLRQALAKRLSPKRFRAKSSWRPEKL 715
Query: 644 -FSDPSPKFAHHHLRSQDPCPPSRSEVLSQSSDSKSEAPDPTQKAWSRSDSDEVPPRVPV 702
SD + R +D E+ D + E+ D + S ++ P P
Sbjct: 716 ELSDLEARRQRRQRRWEDIFNQHEEELRQVDKDKEDESSDNDEVFHSIQAEVQIEPLKPY 775
Query: 703 RTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSS 762
+ + + R SP + Q + A +SS+ R L E+ +K + S +
Sbjct: 776 ISNPKKIEVQER-SPSVPNNQDH--AHHVKFSSSVPQRSLLEQAQKPI---DIRQRSSQN 829
Query: 763 NSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKK--EVFRPLKPAGE 820
S S+ S R SS + Q+L + P+ K ++ P+ E
Sbjct: 830 RQNWLAASESSSEEESPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVYLTNE 889
Query: 821 -VDLTALAKELR-----AVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGP 874
V AL++ R ++PP + DY + S TD +DD DES
Sbjct: 890 WVGYNALSEIFRNDWLTPAPVIQPPEEDGDYVELYDASADTDGDDD-------DESNDTF 942
Query: 875 EDT--RAASSLNLSNGETESVKTMIVHDD 901
EDT A + +L N ++ HDD
Sbjct: 943 EDTYDHANGNDDLDNQVDQANDVCKDHDD 971
Score = 280 bits (717), Expect = 5e-75
Identities = 155/424 (36%), Positives = 238/424 (56%), Gaps = 58/424 (13%)
Query: 949 SPSSGTTVTSVVGFSCDGMRPEAIR--QDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRF 1006
SPS G+ +++ F+ + + ++ ++ S VNVNP P P I Y+K F
Sbjct: 1149 SPSKGSGMSADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPLIHMYEKEF 1208
Query: 1007 NSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGK 1066
SEI C +LWGVNLL+GT S L L+DRSG+ + LI RR F+Q+ VLE LN+L+TISG
Sbjct: 1209 TSEICCGSLWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGH 1268
Query: 1067 KDKLRVYYLSWLRNKILHNDPEVEKKQ--------GWTTVGDLEGCVHYKVVKYERIKFL 1118
K++LRVY+L+WLRNKIL+NDPE +++Q + L GC H+ V+++E ++
Sbjct: 1269 KNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYI 1328
Query: 1119 VIALKSSVEVYAWAPK---------------------------------------PYHKF 1139
IALKSS+ +YAWAPK P ++F
Sbjct: 1329 AIALKSSIHLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRF 1388
Query: 1140 ---------MAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYL 1190
+ K F L HKP+ VDL + +RLK+ + S G+H +D +S + D+ L
Sbjct: 1389 KRPDELLHLLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTL 1448
Query: 1191 PTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIR 1250
P + I P IIILP+ G+ +++ + E + V ++ K ++ W ++P+S+A+
Sbjct: 1449 PKNPLEIIIPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFEC 1508
Query: 1251 SNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFM 1310
+ +T GWG+KAIE+RS+++ L+ + ++L+FLC R DK+FF S S+VYFM
Sbjct: 1509 TQRTTGWGQKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFM 1568
Query: 1311 TLGR 1314
TLG+
Sbjct: 1569 TLGK 1572
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 306 bits (783), Expect = 1e-82
Identities = 157/311 (50%), Positives = 206/311 (66%), Gaps = 11/311 (3%)
Query: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHH 79
DP+ +E+ E +G GTYG+V+K + K GQ AA+K++D D +EEI+ E N+LK S H
Sbjct: 16 DPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEAEYNILKALSDH 75
Query: 80 RNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKN--TKGNTLKEDWIAYISREI 137
N+ +YG + KK + D+LWLV+E C GS+TDLVK +G + E IAYI E
Sbjct: 76 PNVVRFYGIYFKKDKV-NGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEA 134
Query: 138 LRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L GL HLH + IHRD+KG N+LLT VKLVDFGVSAQL T RRNT +GTP+WMAP
Sbjct: 135 LMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAP 194
Query: 198 EVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
EVIAC++ D TYD R D WS GITAIE+ +G PPL D+HPMRALF IPRNPPP+L+ +
Sbjct: 195 EVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPE 254
Query: 258 -WSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI-----RDQPNERQVR--IQLKDHIDRT 309
WS +F FI CL K+Y +RP+ +LL+H FI +D ++Q+ I + + T
Sbjct: 255 LWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGKDVMLQKQLTEFIGIHQCMGGT 314
Query: 310 RKKRGEKDETE 320
K R E+ T+
Sbjct: 315 EKARRERIHTK 325
>gi|134288915 myosin IIIB isoform 1 [Homo sapiens]
Length = 1314
Score = 296 bits (758), Expect = 9e-80
Identities = 157/330 (47%), Positives = 210/330 (63%), Gaps = 15/330 (4%)
Query: 13 IDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINM 72
+ L SL DP +E++E +G GTYG+VYK + + G LAA+K++D D +EEI+ E N+
Sbjct: 15 LGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNI 74
Query: 73 LKKYSHHRNIATYYGAFIKKSPPGH--DDQLWLVMEFCGAGSITDLVKNTK--GNTLKED 128
L+ +H N+ +YG F K H QLWLV+E C GS+T+LVK G L E
Sbjct: 75 LQFLPNHPNVVKFYGMFYKAD---HCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEA 131
Query: 129 WIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTF 188
I+YI L GL HLH + +IHRD+KG N+LLT VKLVDFGVSAQL T RRNT
Sbjct: 132 MISYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTS 191
Query: 189 IGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN 248
+GTP+WMAPEVIAC++ D++YD R D+WS GITAIE+ +G PPL DMHP++ LF IPRN
Sbjct: 192 VGTPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRN 251
Query: 249 PPPR-LKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPN-----ERQVRIQL 302
PPP L +KW ++F FI CL+K++ +RPS LL HPFI+ ++Q+ L
Sbjct: 252 PPPTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVL 311
Query: 303 KD--HIDRTRKKRGEKDETEYEYSGSEEEE 330
+D H + K R E+ T Y + E+
Sbjct: 312 QDQKHQNPVAKTRHERMHTRRPYHVEDAEK 341
>gi|134288892 myosin IIIB isoform 2 [Homo sapiens]
Length = 1341
Score = 296 bits (758), Expect = 9e-80
Identities = 157/330 (47%), Positives = 210/330 (63%), Gaps = 15/330 (4%)
Query: 13 IDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINM 72
+ L SL DP +E++E +G GTYG+VYK + + G LAA+K++D D +EEI+ E N+
Sbjct: 15 LGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNI 74
Query: 73 LKKYSHHRNIATYYGAFIKKSPPGH--DDQLWLVMEFCGAGSITDLVKNTK--GNTLKED 128
L+ +H N+ +YG F K H QLWLV+E C GS+T+LVK G L E
Sbjct: 75 LQFLPNHPNVVKFYGMFYKAD---HCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEA 131
Query: 129 WIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTF 188
I+YI L GL HLH + +IHRD+KG N+LLT VKLVDFGVSAQL T RRNT
Sbjct: 132 MISYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTS 191
Query: 189 IGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN 248
+GTP+WMAPEVIAC++ D++YD R D+WS GITAIE+ +G PPL DMHP++ LF IPRN
Sbjct: 192 VGTPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRN 251
Query: 249 PPPR-LKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPN-----ERQVRIQL 302
PPP L +KW ++F FI CL+K++ +RPS LL HPFI+ ++Q+ L
Sbjct: 252 PPPTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVL 311
Query: 303 KD--HIDRTRKKRGEKDETEYEYSGSEEEE 330
+D H + K R E+ T Y + E+
Sbjct: 312 QDQKHQNPVAKTRHERMHTRRPYHVEDAEK 341
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 269 bits (688), Expect = 1e-71
Identities = 160/419 (38%), Positives = 240/419 (57%), Gaps = 27/419 (6%)
Query: 6 PAKSLVDIDLSSL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEE 64
P + L +D SL + P +F+++E +G G+YG VYK H +TGQ+ AIK + V D +E
Sbjct: 10 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69
Query: 65 EIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNT 124
IK EI+++++ ++ YYG++ K + LW+VME+CGAGS++D+++ + T
Sbjct: 70 IIK-EISIMQQCDSP-HVVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120
Query: 125 LKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
L ED IA I + L+GL +LH IHRDIK N+LL KL DFGV+ QL T+ +
Sbjct: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
Query: 185 RNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFL 244
RNT IGTP+WMAPEVI + Y+ +D+WS GITAIEMAEG PP D+HPMRA+F+
Sbjct: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
Query: 245 IPRNPPPRL-KSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLK 303
IP NPPP K + WS F F++ CLVK+ QR + QLL+HPF+R +R +
Sbjct: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLIN 295
Query: 304 DHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGE--STLRRDFLRLQQ 361
+ +D + KR E + E + +++EE E E + ++V G+ T+R
Sbjct: 296 EAMD-VKLKRQESQQREVD----QDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDG 350
Query: 362 ENK--ERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRRERE 418
N E + L Q L + ++E + + R + ++ K EQ+ +E +
Sbjct: 351 ANTMIEHDDTLPSQ--LGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQ 407
Score = 33.1 bits (74), Expect = 1.8
Identities = 24/100 (24%), Positives = 41/100 (41%), Gaps = 11/100 (11%)
Query: 840 HKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAA----SSLNLSNGETESVKT 895
++ D +ES + + DD E DE SG RA ++ +++ T+ T
Sbjct: 295 NEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTM-VRAVGDEMGTVRVASTMTDGANT 353
Query: 896 MIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSS 935
MI HDD PS+ GT+++ K + +
Sbjct: 354 MIEHDDT------LPSQLGTMVINAEDEEEEGTMKRRDET 387
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 267 bits (683), Expect = 4e-71
Identities = 150/338 (44%), Positives = 209/338 (61%), Gaps = 21/338 (6%)
Query: 17 SLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKY 76
S R+P FEL++ +G+GTYG VYK R+V TG+LAAIKV+ + E+ + + ++ K
Sbjct: 8 SRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKD 67
Query: 77 SHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISRE 136
H NI Y+G+++++ D+LW+ MEFCG GS+ D+ T L E IAY+SRE
Sbjct: 68 CKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYVSRE 119
Query: 137 ILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMA 196
L+GL +LH +HRDIKG N+LLT+N VKL DFGVSAQ+ T+ +R +FIGTPYWMA
Sbjct: 120 TLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMA 179
Query: 197 PEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRLK 254
PEV A + Y+ DLW+ GITAIE+AE PP+ D+HPMRALFL+ ++ PP+LK
Sbjct: 180 PEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLK 237
Query: 255 SK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKR 313
K KWS F F++ L KN +RP+ E+LL+HPF+ Q R + I+L D ++
Sbjct: 238 DKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV-TQHLTRSLAIELLDKVN------ 290
Query: 314 GEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGEST 351
D + Y ++ E V S+ NV E T
Sbjct: 291 -NPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKT 327
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 259 bits (663), Expect = 9e-69
Identities = 152/351 (43%), Positives = 214/351 (60%), Gaps = 28/351 (7%)
Query: 5 SPAKSLVDIDLSSL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
+P L + SL + P +F+++E +G G+YG V+K H ++GQ+ AIK + V D +
Sbjct: 6 APKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQ 65
Query: 64 EEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGN 123
E IK EI+++++ + YYG++ K + LW+VME+CGAGS++D+++ +
Sbjct: 66 EIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNK 116
Query: 124 TLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVG 183
TL ED IA I + L+GL +LH IHRDIK N+LL KL DFGV+ QL T+
Sbjct: 117 TLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMA 176
Query: 184 RRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALF 243
+RNT IGTP+WMAPEVI + Y+ +D+WS GIT+IEMAEG PP D+HPMRA+F
Sbjct: 177 KRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIF 231
Query: 244 LIPRNPPPRL-KSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQL 302
+IP NPPP K + WS F F++ CLVKN QR + QLL+HPFI+ N + V I L
Sbjct: 232 MIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK---NAKPVSI-L 287
Query: 303 KDHIDRT---RKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGES 350
+D I + KR E+ + E EEEEE E E + ++V ES
Sbjct: 288 RDLITEAMEIKAKRHEEQQREL-----EEEEENSDEDELDSHTMVKTSVES 333
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 256 bits (655), Expect = 8e-68
Identities = 140/325 (43%), Positives = 209/325 (64%), Gaps = 20/325 (6%)
Query: 4 DSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DE 62
++P + DI R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + D+
Sbjct: 2 EAPLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD 58
Query: 63 EEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKG 122
I+ EI M+K+ H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T
Sbjct: 59 FSLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT-- 109
Query: 123 NTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTV 182
L E IAY+ RE L+GLA+LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+
Sbjct: 110 GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATI 169
Query: 183 GRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRAL 242
+R +FIGTPYWMAPEV A ++N Y+ D+W+ GITAIE+ E PP+ D+HPMRAL
Sbjct: 170 AKRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRAL 227
Query: 243 FLIPRN--PPPRLKSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVR 299
FL+ ++ PP+LK K KWS F +F++ L KN +RP+ E+LL H F+ R +
Sbjct: 228 FLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALA 287
Query: 300 IQLKDHIDR--TRKKRGEKDETEYE 322
++L D ++ E D+ ++E
Sbjct: 288 VELLDKVNNPDNHAHYTEADDDDFE 312
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 256 bits (655), Expect = 8e-68
Identities = 140/325 (43%), Positives = 209/325 (64%), Gaps = 20/325 (6%)
Query: 4 DSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DE 62
++P + DI R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + D+
Sbjct: 2 EAPLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD 58
Query: 63 EEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKG 122
I+ EI M+K+ H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T
Sbjct: 59 FSLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT-- 109
Query: 123 NTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTV 182
L E IAY+ RE L+GLA+LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+
Sbjct: 110 GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATI 169
Query: 183 GRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRAL 242
+R +FIGTPYWMAPEV A ++N Y+ D+W+ GITAIE+ E PP+ D+HPMRAL
Sbjct: 170 AKRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRAL 227
Query: 243 FLIPRN--PPPRLKSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVR 299
FL+ ++ PP+LK K KWS F +F++ L KN +RP+ E+LL H F+ R +
Sbjct: 228 FLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALA 287
Query: 300 IQLKDHIDR--TRKKRGEKDETEYE 322
++L D ++ E D+ ++E
Sbjct: 288 VELLDKVNNPDNHAHYTEADDDDFE 312
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 252 bits (644), Expect = 1e-66
Identities = 143/330 (43%), Positives = 202/330 (61%), Gaps = 24/330 (7%)
Query: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKLEINMLKKYS 77
DP +F ++ +G G++G+VYKG T ++ AIK++D+ EDE E+I+ EI +L +
Sbjct: 15 DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
Query: 78 HHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREI 137
I Y+G+++K + +LW++ME+ G GS DL+K L+E +IA I REI
Sbjct: 75 SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124
Query: 138 LRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184
Query: 198 EVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
EVI + YD+++D+WS GITAIE+A+G PP D+HPMR LFLIP+N PP L+ +
Sbjct: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239
Query: 258 WSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKD 317
SK F F+E CL K+ RP+ ++LLKH FI + +L D R K
Sbjct: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRW------KS 292
Query: 318 ETEYEYSGSEEEEEEVPEQEGEPSSIVNVP 347
E E S SE+ + + ++GE I P
Sbjct: 293 EGHGEESSSEDSDIDGEAEDGEQGPIWTFP 322
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 248 bits (633), Expect = 3e-65
Identities = 138/319 (43%), Positives = 197/319 (61%), Gaps = 18/319 (5%)
Query: 16 SSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKLEINML 73
+++ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ EDE E+I+ EI +L
Sbjct: 15 NNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVL 74
Query: 74 KKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYI 133
+ + YYG+++K S +LW++ME+ G GS DL++ E IA +
Sbjct: 75 SQCDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATM 124
Query: 134 SREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
+EIL+GL +LH IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+
Sbjct: 125 LKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPF 184
Query: 194 WMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRL 253
WMAPEVI + YD ++D+WS GITAIE+A+G PP DMHPMR LFLIP+N PP L
Sbjct: 185 WMAPEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTL 239
Query: 254 KSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKR 313
++K F FI+ CL K+ RP+ ++LLKH FI + +L D R + +
Sbjct: 240 VG-DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEG 298
Query: 314 GEKDETEYEYSGSEEEEEE 332
DE++ E S SE E
Sbjct: 299 HSDDESDSEGSDSESTSRE 317
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 243 bits (619), Expect = 1e-63
Identities = 138/319 (43%), Positives = 194/319 (60%), Gaps = 24/319 (7%)
Query: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKLEINMLKKYS 77
DP +F +E +G G++G+V+KG +T ++ AIK++D+ EDE E+I+ EI +L +
Sbjct: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 78 HHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREI 137
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 79 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128
Query: 138 LRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188
Query: 198 EVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
EVI + YD ++D+WS GITAIE+A G PP ++HPM+ LFLIP+N PP L+
Sbjct: 189 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 242
Query: 258 WSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKD 317
+SK F+E CL K RP+ ++LLKH FI + +L D R K
Sbjct: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRW------KA 296
Query: 318 ETEYEYSGSEEEEEEVPEQ 336
E ++ S SE+ + E Q
Sbjct: 297 EQSHDDSSSEDSDAETDGQ 315
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 243 bits (619), Expect = 1e-63
Identities = 138/319 (43%), Positives = 194/319 (60%), Gaps = 24/319 (7%)
Query: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKLEINMLKKYS 77
DP +F +E +G G++G+V+KG +T ++ AIK++D+ EDE E+I+ EI +L +
Sbjct: 31 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 90
Query: 78 HHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREI 137
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 91 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 140
Query: 138 LRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 141 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 200
Query: 198 EVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
EVI + YD ++D+WS GITAIE+A G PP ++HPM+ LFLIP+N PP L+
Sbjct: 201 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 254
Query: 258 WSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKD 317
+SK F+E CL K RP+ ++LLKH FI + +L D R K
Sbjct: 255 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRW------KA 308
Query: 318 ETEYEYSGSEEEEEEVPEQ 336
E ++ S SE+ + E Q
Sbjct: 309 EQSHDDSSSEDSDAETDGQ 327
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 241 bits (616), Expect = 3e-63
Identities = 149/401 (37%), Positives = 224/401 (55%), Gaps = 22/401 (5%)
Query: 17 SLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEEEEIKLEINMLKK 75
SL+DP FEL++ VG GTYG VYK R T +LAA+K++ + D+ ++ EI +L++
Sbjct: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67
Query: 76 YSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISR 135
H N+ Y G++++ +D+LW+ MEFCG GS+ ++ T L+E IAY+ R
Sbjct: 68 -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118
Query: 136 EILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
E L+GL HLH IHRDIKG N+LLT +VKL DFGVS +L +V +R +FIGTPYWM
Sbjct: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178
Query: 196 APEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRL 253
APEV A + Y+ D+W+ GITAIE+ E PPL +HPMRAL L+ ++ PP+L
Sbjct: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236
Query: 254 KSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKK 312
+ K +W++ F F++ L KN +RP+ E+LL+HPF Q R + QL D
Sbjct: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ-LPRALLTQLLDKASDPHLG 295
Query: 313 RGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRR 372
++ E E + + + G+ P E + ++ ++ ++ L
Sbjct: 296 TPSPEDCELE---TYDMFPDTIHSRGQHGPAERTPSEIQFHQ--VKFGAPRRKETDPL-N 349
Query: 373 QQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQ 413
+ +E L +EE LL Q+ +E++ R E Q
Sbjct: 350 EPWEEEWTLLGKEELSGSLLQSVQEALEERSLTIRSASEFQ 390
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 239 bits (610), Expect = 1e-62
Identities = 200/761 (26%), Positives = 348/761 (45%), Gaps = 93/761 (12%)
Query: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE-EEIKLEINMLKKYSH 78
+P +E++ +G+G +G+VYK ++ +T LAA KV+D +EE E+ +EI++L H
Sbjct: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88
Query: 79 HRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREIL 138
NI AF +++ LW+++EFC G++ D V L E I + ++ L
Sbjct: 89 P-NIVKLLDAFY------YENNLWILIEFCAGGAV-DAVMLELERPLTESQIQVVCKQTL 140
Query: 139 RGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
L +LH + +IHRD+K N+L T + ++KL DFGVSA+ RT+ RR++FIGTPYWMAPE
Sbjct: 141 DALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPE 200
Query: 199 VIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRL-KSKK 257
V+ C+ + D YDY++D+WS GIT IEMAE PP +++PMR L I ++ PP L + +
Sbjct: 201 VVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSR 260
Query: 258 WSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNE--RQVRIQLKDHIDRTRKKRGE 315
WS F F++ CL KN R +T QLL+HPF+ N+ R++ + K +
Sbjct: 261 WSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEV--------- 311
Query: 316 KDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQL 375
TE G EE+EEE E + + +P D E + S+ +
Sbjct: 312 ---TEEVEDGKEEDEEE------ETENSLPIPASKRASSDLSIASSEEDKLSQNACILES 362
Query: 376 LQEQQLREQEEYK--RQLLAERQKRIEQQK---EQRRRLEEQQRREREARRQQEREQRRR 430
+ E+ R E K ++L E+ E +K + + + Q + +
Sbjct: 363 VSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKEN 422
Query: 431 EQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQ 490
E+E++ +LE L + E + + E ++ I LE H +++ QE+
Sbjct: 423 EREKRPKLENL-----PDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEK 477
Query: 491 AMLLECRWREMEEHRQ-----AERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPPPPQQE 545
+ E + + EE + + + ++ +++A + ++ + ++ +
Sbjct: 478 QQMFENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKT 537
Query: 546 RSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVL--EPPVPSRSESF 603
+ + + E AD A++V++ + S+ + + G+ L +P V +
Sbjct: 538 QKDVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEA--- 594
Query: 604 SNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQDPCP 663
G ++ V P + V+ + + KN ++ S + D +++P
Sbjct: 595 --GGTKEV------PIKEIVEMNEIEEGKNKEQAINSSENIMD----------INEEPGT 636
Query: 664 PSRSEVLSQSS----DSKSEAPDPTQKAWSRSDSD-------------EVP------PRV 700
E+ SS + +S D QKA D E+P P V
Sbjct: 637 TEGEEITESSSTEEMEVRSVVADTDQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEV 696
Query: 701 PV--RTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEP 739
V + T PVL + SG+ + G + T +I P
Sbjct: 697 TVVSQPTEPQPVLIPSININSDSGENKEEIGSLSKTETILP 737
Score = 62.0 bits (149), Expect = 4e-09
Identities = 45/163 (27%), Positives = 89/163 (54%), Gaps = 13/163 (7%)
Query: 365 ERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQE 424
E LRRQ+L + + L+++E+ +Q L +++QQ+EQ R EQ+ + +RQ +
Sbjct: 821 EELRFLRRQELRELRFLQKEEQRAQQQL---NSKLQQQREQIFRRFEQEMMSK--KRQYD 875
Query: 425 REQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQ 484
+E E+++K+ +E L E+E R +E +R++ EQE ++L + Q L+ ++
Sbjct: 876 QEIENLEKQQKQTIERL-----EQEHTNRLRDEAKRIKGEQE---KELSKFQNMLKNRKK 927
Query: 485 QLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHD 527
+++ E + +E+ + R+ E Q Q QEQ ++ Q +
Sbjct: 928 EVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQE 970
Score = 57.4 bits (137), Expect = 9e-08
Identities = 58/224 (25%), Positives = 106/224 (47%), Gaps = 38/224 (16%)
Query: 352 LRRDFLR----LQQENKERSEALRRQQLLQEQQL-----REQEEYKRQLLAERQKRIEQQ 402
LRR LR LQ+E + + L + Q +Q+ +E KRQ E + +QQ
Sbjct: 826 LRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQ 885
Query: 403 KEQRRRLEEQ--QRREREARR---QQERE----QRRREQEEKRRLEELERR----RKEEE 449
K+ RLE++ R EA+R +QE+E Q + +K + E+E+ RKE
Sbjct: 886 KQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELM 945
Query: 450 ERRRAEEEKRRVEREQEYIRRQ-----------LEEEQRHLEVLQQQLLQEQAMLLECR- 497
+RR+ E + + +EQE++++Q +++++ L ++++ L + L+ R
Sbjct: 946 KRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRARE 1005
Query: 498 ---WREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQ 538
W E+EE E+ Q QQ + +H + H + ++Q
Sbjct: 1006 AAIW-ELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQ 1048
Score = 53.1 bits (126), Expect = 2e-06
Identities = 50/242 (20%), Positives = 122/242 (50%), Gaps = 24/242 (9%)
Query: 292 QPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGEST 351
Q E++ + QL + + R++ + E E + ++E ++ + +I + E T
Sbjct: 838 QKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHT 897
Query: 352 --LRRDFLRLQ-QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR 408
LR + R++ ++ KE S+ + +++ + E E+ ++L R++ ++++KE+ +
Sbjct: 898 NRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKEL---RKELMKRRKEELAQ 954
Query: 409 LEEQQRREREARRQQEREQRRRE--QEEKRRLEELER---RRKEEEERRRA----EEEKR 459
+ Q +E ++QQE + ++ Q++K L +ER K++ R R E E+R
Sbjct: 955 SQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEER 1014
Query: 460 RVEREQEYIRRQLEEE---------QRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERL 510
++ + + +++QL+++ +RH + +Q Q ++ E + R+ +E + ++
Sbjct: 1015 HLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKI 1074
Query: 511 QR 512
QR
Sbjct: 1075 QR 1076
Score = 50.1 bits (118), Expect = 1e-05
Identities = 75/311 (24%), Positives = 143/311 (45%), Gaps = 44/311 (14%)
Query: 310 RKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQE--NKERS 367
RK+ ++ + E S +E+E V +Q+ E + +L++ + + E N ER
Sbjct: 941 RKELMKRRKEELAQSQHAQEQEFVQKQQQEL--------DGSLKKIIQQQKAELANIERE 992
Query: 368 EALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQ--RRRLEEQQRREREARRQQER 425
+QQL++ ++ E +R L + Q +Q K+Q +R + +R E+E + Q
Sbjct: 993 CLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRY 1052
Query: 426 EQRRREQEEKRRLEELER----RRKEEEERRRAEEEKRRV------EREQEYIRR---QL 472
QR E+ + R+ +E R +R E + R ++ R+ +++++ I++ Q
Sbjct: 1053 NQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQE 1112
Query: 473 EEEQRHLEVLQQQLLQEQA--MLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRR 530
E+ Q++ + Q Q + Q + L+C E H QLQ E+ +LL ++H+ ++
Sbjct: 1113 EKRQKNERMAQHQKHENQMRDLQLQCEANVRELH--------QLQNEKCHLL-VEHETQK 1163
Query: 531 ---PHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQ 587
+HSQ+ +E+ +P E E A + +E E F+ T S S Q
Sbjct: 1164 LKELDEEHSQE-LKEWREKLRPRKKTLEE----EFARKLQEQEVFFKMTGESECLNPSTQ 1218
Query: 588 TGRVLEPPVPS 598
+ P+PS
Sbjct: 1219 SRISKFYPIPS 1229
Score = 42.0 bits (97), Expect = 0.004
Identities = 44/188 (23%), Positives = 85/188 (45%), Gaps = 7/188 (3%)
Query: 292 QPNERQVRIQLKDHIDRTRK---KRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPG 348
Q + ++ QLKD R KR EK ETE ++ EE+ ++ + + +
Sbjct: 1017 QEKHQLLKQQLKDQYFMQRHQLLKRHEK-ETEQMQRYNQRLIEELKNRQTQERARLPKIQ 1075
Query: 349 ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR 408
S + ++ + S A Q + +Q QEE +++ ER + ++ + Q R
Sbjct: 1076 RSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQK--NERMAQHQKHENQMRD 1133
Query: 409 LEEQ-QRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEY 467
L+ Q + RE + Q + + E ++L+EL+ +E + R + R+ E+E+
Sbjct: 1134 LQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEF 1193
Query: 468 IRRQLEEE 475
R+ E+E
Sbjct: 1194 ARKLQEQE 1201
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,232,670
Number of Sequences: 37866
Number of extensions: 3038661
Number of successful extensions: 90324
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1935
Number of HSP's successfully gapped in prelim test: 1622
Number of HSP's that attempted gapping in prelim test: 19286
Number of HSP's gapped (non-prelim): 23724
length of query: 1320
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1206
effective length of database: 13,930,794
effective search space: 16800537564
effective search space used: 16800537564
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.