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Search of human proteins with 22035600
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22035600 mitogen-activated protein kinase kinase kinase
kinase 2 [Homo sapiens]
(820 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 1679 0.0
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 906 0.0
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 853 0.0
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 853 0.0
gi|110611908 mitogen-activated protein kinase kinase kinase kina... 646 0.0
gi|6005810 mitogen-activated protein kinase kinase kinase kinase... 626 e-179
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 269 7e-72
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 258 2e-68
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 257 3e-68
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 257 3e-68
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 253 4e-67
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 249 6e-66
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 249 6e-66
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 249 6e-66
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 249 6e-66
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 249 6e-66
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 249 6e-66
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 249 6e-66
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 249 6e-66
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 248 2e-65
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 243 4e-64
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 243 4e-64
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 243 4e-64
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 243 4e-64
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 243 7e-64
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 242 9e-64
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 241 2e-63
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 241 2e-63
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 241 2e-63
gi|145275208 myosin IIIA [Homo sapiens] 238 2e-62
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 1679 bits (4348), Expect = 0.0
Identities = 820/820 (100%), Positives = 820/820 (100%)
Query: 1 MALLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQ 60
MALLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQ
Sbjct: 1 MALLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQ 60
Query: 61 EITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREA 120
EITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREA
Sbjct: 61 EITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREA 120
Query: 121 LKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAP 180
LKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAP
Sbjct: 121 LKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAP 180
Query: 181 EVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKT 240
EVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKT
Sbjct: 181 EVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKT 240
Query: 241 RWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASDPHLGTPSPE 300
RWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASDPHLGTPSPE
Sbjct: 241 RWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASDPHLGTPSPE 300
Query: 301 DCELETYDMFPDTIHSRGQHGPAERTPSEIQFHQVKFGAPRRKETDPLNEPWEEEWTLLG 360
DCELETYDMFPDTIHSRGQHGPAERTPSEIQFHQVKFGAPRRKETDPLNEPWEEEWTLLG
Sbjct: 301 DCELETYDMFPDTIHSRGQHGPAERTPSEIQFHQVKFGAPRRKETDPLNEPWEEEWTLLG 360
Query: 361 KEELSGSLLQSVQEALEERSLTIRSASEFQELDSPDDTMGTIKRAPFLGPLPTDPPAEEP 420
KEELSGSLLQSVQEALEERSLTIRSASEFQELDSPDDTMGTIKRAPFLGPLPTDPPAEEP
Sbjct: 361 KEELSGSLLQSVQEALEERSLTIRSASEFQELDSPDDTMGTIKRAPFLGPLPTDPPAEEP 420
Query: 421 LSSPPGTLPPPPSGPNSSPLLPTAWATMKQREDPERSSCHGLPPTPKVHMGACFSKVFNG 480
LSSPPGTLPPPPSGPNSSPLLPTAWATMKQREDPERSSCHGLPPTPKVHMGACFSKVFNG
Sbjct: 421 LSSPPGTLPPPPSGPNSSPLLPTAWATMKQREDPERSSCHGLPPTPKVHMGACFSKVFNG 480
Query: 481 CPLRIHAAVTWIHPVTRDQFLVVGAEEGIYTLNLHELHEDTLEKLISHRCSWLYCVNNVL 540
CPLRIHAAVTWIHPVTRDQFLVVGAEEGIYTLNLHELHEDTLEKLISHRCSWLYCVNNVL
Sbjct: 481 CPLRIHAAVTWIHPVTRDQFLVVGAEEGIYTLNLHELHEDTLEKLISHRCSWLYCVNNVL 540
Query: 541 LSLSGKSTHIWAHDLPGLFEQRRLQQQVPLSIPTNRLTQRIIPRRFALSTKIPDTKGCLQ 600
LSLSGKSTHIWAHDLPGLFEQRRLQQQVPLSIPTNRLTQRIIPRRFALSTKIPDTKGCLQ
Sbjct: 541 LSLSGKSTHIWAHDLPGLFEQRRLQQQVPLSIPTNRLTQRIIPRRFALSTKIPDTKGCLQ 600
Query: 601 CRVVRNPYTGATFLLAALPTSLLLLQWYEPLQKFLLLKNFSSPLPSPAGMLEPLVLDGKE 660
CRVVRNPYTGATFLLAALPTSLLLLQWYEPLQKFLLLKNFSSPLPSPAGMLEPLVLDGKE
Sbjct: 601 CRVVRNPYTGATFLLAALPTSLLLLQWYEPLQKFLLLKNFSSPLPSPAGMLEPLVLDGKE 660
Query: 661 LPQVCVGAEGPEGPGCRVLFHVLPLEAGLTPDILIPPEGIPGSAQQVIQVDRDTILVSFE 720
LPQVCVGAEGPEGPGCRVLFHVLPLEAGLTPDILIPPEGIPGSAQQVIQVDRDTILVSFE
Sbjct: 661 LPQVCVGAEGPEGPGCRVLFHVLPLEAGLTPDILIPPEGIPGSAQQVIQVDRDTILVSFE 720
Query: 721 RCVRIVNMQGEPTATLAPELTFDFPIETVVCLQDSVLAFWSHGMQGRSLDTNEVTQEITD 780
RCVRIVNMQGEPTATLAPELTFDFPIETVVCLQDSVLAFWSHGMQGRSLDTNEVTQEITD
Sbjct: 721 RCVRIVNMQGEPTATLAPELTFDFPIETVVCLQDSVLAFWSHGMQGRSLDTNEVTQEITD 780
Query: 781 ETRIFRVLGAHRDIILESIPTDNPEAHSNLYILTGHQSTY 820
ETRIFRVLGAHRDIILESIPTDNPEAHSNLYILTGHQSTY
Sbjct: 781 ETRIFRVLGAHRDIILESIPTDNPEAHSNLYILTGHQSTY 820
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 906 bits (2342), Expect = 0.0
Identities = 469/893 (52%), Positives = 615/893 (68%), Gaps = 82/893 (9%)
Query: 6 DVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITIL 65
D+S ++P++ FEL+QR+G+GTYGDVYKAR+ T ELAA+K++KL+PG+D + +QQEI ++
Sbjct: 6 DLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMM 65
Query: 66 RECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLH 125
++C+HPN+VAY GSYLR D+LWICMEFCGGGSLQ+IYH TGPL E QIAYV RE L+GL+
Sbjct: 66 KDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLY 125
Query: 126 HLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAV 185
+LHS+GK+HRDIKGAN+LLT G VKLADFGVS ++TA++AKR+SFIGTPYWMAPEVAAV
Sbjct: 126 YLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAV 185
Query: 186 ERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQN 245
ERKGGYN+LCD+WA+GITAIEL ELQPP+F LHPMRAL LM+KS+FQPPKL+DK +W+ +
Sbjct: 186 ERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNS 245
Query: 246 FHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASDP-HLGTPSPEDCEL 304
FHHF+K+ALTKNPKKRPTAEKLLQHPF TQ L R+L +LLDK ++P H +D +
Sbjct: 246 FHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDP 305
Query: 305 ETYDMFPDTIHSRGQHGPAERTPSEIQFHQVKFGAPRRKETDPLNEPWEEEWTLLGKEEL 364
E P IHS ++ E+T SEI F QVKF P RKET+P +E + + L EE+
Sbjct: 306 EPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEI 365
Query: 365 --------------------------SGSLLQSVQEALEERS------------------ 380
+ SLL+SV+E L +R
Sbjct: 366 YYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHS 425
Query: 381 ---------LTIRSASEF--QELDS-PDDTMGTIKRAPFLGPLPTDPPAEEPLSSPPGTL 428
L + S F QE+ S D+ GTIKR P G P++ P PP L
Sbjct: 426 TLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSG--SPAKPSQVPPRPPPPRL 483
Query: 429 PPPP-----SGPNSSPLLPTAWATM--------------KQREDPERSSCHGLPPTPKVH 469
PP +G +S L ++ K+++D + +GLPPTPKVH
Sbjct: 484 PPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVH 543
Query: 470 MGACFSKVFNGCPLRIHAAVTWIHPVTRDQFLVVGAEEGIYTLNLHELHEDTLEKLISHR 529
MGACFSKVFNGCPL+IH A +WI+P TRDQ+L+ GAEEGIYTLNL+ELHE ++E+L R
Sbjct: 544 MGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRR 603
Query: 530 CSWLYCVNNVLLSLSGKSTHIWAHDLPGLFEQRRLQQQVPLSIPTNRLTQRIIPRRFALS 589
C+WLY +NN LLS+SGK++ +++H+LPGLF+ R Q++P++IP ++L RI+PR+F++S
Sbjct: 604 CTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFSVS 663
Query: 590 TKIPDTKGCLQCRVVRNPYTGATFLLAALPTSLLLLQWYEPLQKFLLLKNFSSPLPSPAG 649
KIP+TK C +C VVRNPYTG +L AL TS++LL+W EP+QKF+L+K+ P+P P
Sbjct: 664 AKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLR 723
Query: 650 MLEPLVLDGKELPQVCVGAEGPEGPGCRVLFHVLPLEAGLTPDILIPPEGIPGSAQQVIQ 709
M E LV+ +E P VCVG G + + T + + V Q
Sbjct: 724 MFEMLVVPEQEYPLVCVGVS--RGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQ 781
Query: 710 VDRDTILVSFERCVRIVNMQG--EPTATLAPELTFDFPIETVVCLQDSVLAFWSHGMQGR 767
++RDTILV + C++IVN+QG + + L+ ELTFDF IE++VCLQDSVLAFW HGMQGR
Sbjct: 782 LERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGR 841
Query: 768 SLDTNEVTQEITDETRIFRVLGAHRDIILESIPTDNPEAHSNLYILTGHQSTY 820
S +NEVTQEI+D TRIFR+LG+ R ++LES PTDNP A+SNLYIL GH+++Y
Sbjct: 842 SFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPTANSNLYILAGHENSY 894
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 853 bits (2205), Expect = 0.0
Identities = 448/850 (52%), Positives = 592/850 (69%), Gaps = 48/850 (5%)
Query: 6 DVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITIL 65
D+ ++P+ +EL+QRVG+GTYGDVYKAR+ T ELAAVKI+KL+PGDD S +QQEI ++
Sbjct: 10 DILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMV 69
Query: 66 RECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLH 125
+EC+H N+VAY GSYL ++LWICME+CGGGSLQ+IYH TGPL E QIAYVCRE L+GL
Sbjct: 70 KECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLA 129
Query: 126 HLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAV 185
+LH++GK+HRDIKGAN+LLT GDVKLADFGV+ ++TA++AKR+SFIGTPYWMAPEVAAV
Sbjct: 130 YLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAV 189
Query: 186 ERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQN 245
E+ GGYN+LCD+WA+GITAIELGELQPP+F LHPMRAL LMSKS+FQPPKL+DKT+W+
Sbjct: 190 EKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSST 249
Query: 246 FHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ-LPRALLTQLLDKASDP--HLGTPSPEDC 302
FH+F+K+ALTKNPKKRPTAE+LL H F Q L RAL +LLDK ++P H +D
Sbjct: 250 FHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDD 309
Query: 303 ELETYDMFPDTIHSRGQHGPAERTPSEIQFHQVKFGAPRRKETDPLNEPWEEEWTLLGKE 362
+ E + + TI S ++ AERT SEI F +++F P RKET+ +E +G
Sbjct: 310 DFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDE--------MGLS 361
Query: 363 ELSGSLLQ---SVQEALEERSLTIRS----------ASEFQELDSPD-DTMGTIK----- 403
+LQ V A +S + R+ S + E + PD + TIK
Sbjct: 362 SDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDS 421
Query: 404 --RAPFLGPLPTDP---PAEEPLSSPPG-----TLPPPPSGPNSSPLLPTAWATMKQRED 453
RAP + + P P E S G + G +P LP K + D
Sbjct: 422 ESRAPQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLP----RKKDKRD 477
Query: 454 PERSSCHGLPPTPKVHMGACFSKVFNGCPLRIHAAVTWIHPVTRDQFLVVGAEEGIYTLN 513
+ + +GLPPTPKV MGACFSKVF+GCPL+I+ A +WIHP T+DQ+++ G E+GIYTLN
Sbjct: 478 FPKPAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLN 537
Query: 514 LHELHEDTLEKLISHRCSWLYCVNNVLLSLS-GKSTHIWAHDLPGLFEQRRLQQQVPLSI 572
L+ELHE T+E+L +C+WLY +NN L+SLS GK+ +++H+L LFE + + + I
Sbjct: 538 LNELHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAK-KPGLAAHI 596
Query: 573 PTNRLTQRIIPRRFALSTKIPDTKGCLQCRVVRNPYTGATFLLAALPTSLLLLQWYEPLQ 632
T+R RI+PR+FAL+TKIPDTKGC +C +VRNPYTG +L AL + ++LLQWYEP+Q
Sbjct: 597 QTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQ 656
Query: 633 KFLLLKNFSSPLPSPAGMLEPLVLDGKELPQVCVGAEGPEGPGCRVLFHVLPLEAGLTPD 692
KF+L+K+F PLPSP + E LV+ +E P VCV V F + L + +
Sbjct: 657 KFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWF 716
Query: 693 ILIPPEGIPGSAQQVIQVDRDTILVSFERCVRIVNMQG--EPTATLAPELTFDFPIETVV 750
I + V Q++RDT+LV ++ V+IVN+QG + + LA EL+FDF IE+VV
Sbjct: 717 TEIGAGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVV 776
Query: 751 CLQDSVLAFWSHGMQGRSLDTNEVTQEITDETRIFRVLGAHRDIILESIPTDNPEAHSNL 810
CLQDSVLAFW HGMQG+S ++EVTQEI+DETR+FR+LG+ R ++LES PT+NP AHSNL
Sbjct: 777 CLQDSVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNL 836
Query: 811 YILTGHQSTY 820
YIL GH+++Y
Sbjct: 837 YILAGHENSY 846
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 853 bits (2205), Expect = 0.0
Identities = 448/850 (52%), Positives = 592/850 (69%), Gaps = 48/850 (5%)
Query: 6 DVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITIL 65
D+ ++P+ +EL+QRVG+GTYGDVYKAR+ T ELAAVKI+KL+PGDD S +QQEI ++
Sbjct: 10 DILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMV 69
Query: 66 RECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLH 125
+EC+H N+VAY GSYL ++LWICME+CGGGSLQ+IYH TGPL E QIAYVCRE L+GL
Sbjct: 70 KECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLA 129
Query: 126 HLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAV 185
+LH++GK+HRDIKGAN+LLT GDVKLADFGV+ ++TA++AKR+SFIGTPYWMAPEVAAV
Sbjct: 130 YLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAV 189
Query: 186 ERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQN 245
E+ GGYN+LCD+WA+GITAIELGELQPP+F LHPMRAL LMSKS+FQPPKL+DKT+W+
Sbjct: 190 EKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSST 249
Query: 246 FHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ-LPRALLTQLLDKASDP--HLGTPSPEDC 302
FH+F+K+ALTKNPKKRPTAE+LL H F Q L RAL +LLDK ++P H +D
Sbjct: 250 FHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDD 309
Query: 303 ELETYDMFPDTIHSRGQHGPAERTPSEIQFHQVKFGAPRRKETDPLNEPWEEEWTLLGKE 362
+ E + + TI S ++ AERT SEI F +++F P RKET+ +E +G
Sbjct: 310 DFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDE--------MGLS 361
Query: 363 ELSGSLLQ---SVQEALEERSLTIRS----------ASEFQELDSPD-DTMGTIK----- 403
+LQ V A +S + R+ S + E + PD + TIK
Sbjct: 362 SDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDS 421
Query: 404 --RAPFLGPLPTDP---PAEEPLSSPPG-----TLPPPPSGPNSSPLLPTAWATMKQRED 453
RAP + + P P E S G + G +P LP K + D
Sbjct: 422 ESRAPQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLP----RKKDKRD 477
Query: 454 PERSSCHGLPPTPKVHMGACFSKVFNGCPLRIHAAVTWIHPVTRDQFLVVGAEEGIYTLN 513
+ + +GLPPTPKV MGACFSKVF+GCPL+I+ A +WIHP T+DQ+++ G E+GIYTLN
Sbjct: 478 FPKPAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLN 537
Query: 514 LHELHEDTLEKLISHRCSWLYCVNNVLLSLS-GKSTHIWAHDLPGLFEQRRLQQQVPLSI 572
L+ELHE T+E+L +C+WLY +NN L+SLS GK+ +++H+L LFE + + + I
Sbjct: 538 LNELHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAK-KPGLAAHI 596
Query: 573 PTNRLTQRIIPRRFALSTKIPDTKGCLQCRVVRNPYTGATFLLAALPTSLLLLQWYEPLQ 632
T+R RI+PR+FAL+TKIPDTKGC +C +VRNPYTG +L AL + ++LLQWYEP+Q
Sbjct: 597 QTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQ 656
Query: 633 KFLLLKNFSSPLPSPAGMLEPLVLDGKELPQVCVGAEGPEGPGCRVLFHVLPLEAGLTPD 692
KF+L+K+F PLPSP + E LV+ +E P VCV V F + L + +
Sbjct: 657 KFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWF 716
Query: 693 ILIPPEGIPGSAQQVIQVDRDTILVSFERCVRIVNMQG--EPTATLAPELTFDFPIETVV 750
I + V Q++RDT+LV ++ V+IVN+QG + + LA EL+FDF IE+VV
Sbjct: 717 TEIGAGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVV 776
Query: 751 CLQDSVLAFWSHGMQGRSLDTNEVTQEITDETRIFRVLGAHRDIILESIPTDNPEAHSNL 810
CLQDSVLAFW HGMQG+S ++EVTQEI+DETR+FR+LG+ R ++LES PT+NP AHSNL
Sbjct: 777 CLQDSVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNL 836
Query: 811 YILTGHQSTY 820
YIL GH+++Y
Sbjct: 837 YILAGHENSY 846
>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
1 isoform 1 [Homo sapiens]
Length = 821
Score = 646 bits (1666), Expect = 0.0
Identities = 362/845 (42%), Positives = 502/845 (59%), Gaps = 70/845 (8%)
Query: 6 DVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITIL 65
D+ +DPRD ++LLQR+G GTYG+V+KARD V+ +L A+K+VK++P DD+S+LQ+EI IL
Sbjct: 7 DIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILIL 66
Query: 66 RECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLH 125
+ CRH N+VAY GSYL +LWICMEFCG GSLQ+IY TG L E QI+YVCRE L+GL
Sbjct: 67 KTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLA 126
Query: 126 HLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAV 185
+LHSQ KIHRDIKGAN+L+ G+V+LADFG+S ++ A++A+R SFIGTPYWMAPEVAAV
Sbjct: 127 YLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAV 186
Query: 186 ERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQN 245
KGGYNELCD+W+LGITAIEL ELQPPLF +HP+R L LM+KS +QPP+L++K +W+
Sbjct: 187 ALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAA 246
Query: 246 FHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ-LPRALLTQLLDKASDPHLGTPSPEDCEL 304
FH+F+K+ LTK+PKKRP+A K+L H +Q L R L+ LLDK +P G PS D E
Sbjct: 247 FHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKG-PSIGDIED 305
Query: 305 ETYDM---FPDTIHSRGQHGPAERTPSEIQFHQVKFGAPRRKETDP------LNEPWEEE 355
E ++ P I S + ++ ++F R ET P L P
Sbjct: 306 EEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPP---- 361
Query: 356 WTLLGKEELSGSLLQSVQEALEERSLTIRSASEFQELDSPDDTMGTIKRAPFLGPLPTDP 415
+ ++ + + L+ S ++ ++D P T PLP P
Sbjct: 362 --------------RDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPP------PLPPKP 401
Query: 416 PAEEPLSSPPGTL----------------PPPPSGPNSSPLLPTAWATMKQREDP----- 454
P PG++ PPP+ P P T+ + +P
Sbjct: 402 KFRSPSDEGPGSMGDDGQLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNP 461
Query: 455 ---ERSSCHGLPP-TPKVHMGAC--FSKVFNGCPLRIHAAVTWIHPVTRDQFLVVGAEEG 508
E LPP K+ C K+FNGCPLRIH+ W HP T+DQ L++GAEEG
Sbjct: 462 PSRELDKPPLLPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEG 521
Query: 509 IYTLNLHELHEDTLEKLISHRCSWLYCVNNVLLSLSGKSTHIWAHDLPGLFEQRRLQQQV 568
I+ LN ++ E TLE L R +W+Y +NNVL+SLSGK+ H+++H + GL E++ +
Sbjct: 522 IFILNRND-QEATLEMLFPSRTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGN 580
Query: 569 PLSIPTNRLTQRIIPRRFALSTKIPDTKGCLQCRVVRNPYTGATFLLAALPTSLLLLQWY 628
P++ + R++ R+ +STKI DTKGC C V +G FL AL TS++LLQWY
Sbjct: 581 PIA---HISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWY 637
Query: 629 EPLQKFLLLKNFSSPLPSPAGMLEPLVLDGKELPQVCVGAEGPEGPGCRVLFHVLPLEAG 688
+P+ KFLL++ PLP+P + L G ELP VC+G P PG VLFH + G
Sbjct: 638 QPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGV-SPGRPGKSVLFHT--VRFG 694
Query: 689 LTPDILIPPEGIPGSAQQVIQVDRDTILVSFERCVRIVNMQGEPTATL-APELTFDFPIE 747
L QV QV+ D ++V + V++V +G P L PE+ +E
Sbjct: 695 ALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVE 754
Query: 748 TVVCLQDSVLAFWSHGMQGRSLDTNEVTQEITDETRIFRVLGAHRDIILESIPTDNPEAH 807
V + + AFW HG+Q +L ++++ QE+ D T FR+LG+ R +++E+ P D+P A
Sbjct: 755 AVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRPVVVETRPVDDPTAP 814
Query: 808 SNLYI 812
SNLYI
Sbjct: 815 SNLYI 819
>gi|6005810 mitogen-activated protein kinase kinase kinase kinase 1
isoform 2 [Homo sapiens]
Length = 833
Score = 626 bits (1615), Expect = e-179
Identities = 359/845 (42%), Positives = 496/845 (58%), Gaps = 75/845 (8%)
Query: 6 DVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITIL 65
D+ +DPRD ++LLQR+G GTYG+V+KARD V+ +L A+K+VK++P DD+S+LQ+EI IL
Sbjct: 7 DIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILIL 66
Query: 66 RECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLH 125
+ CRH N+VAY GSYL +LWICMEFCG GSLQ+IY TG L E QI+YVCRE L+GL
Sbjct: 67 KTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLA 126
Query: 126 HLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAV 185
+LHSQ KIHRDIKGAN+L+ G+V+LADFG+S ++ A++A+R SFIGTPYWMAPEVAAV
Sbjct: 127 YLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAV 186
Query: 186 ERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQN 245
KGGYNELCD+W+LGITAIEL ELQPPLF +HP+R L LM+KS +QPP+L++K +W+
Sbjct: 187 ALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAA 246
Query: 246 FHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ-LPRALLTQLLDKASDPHLGTPSPEDCEL 304
FH+F+K+ LTK+PKKRP+A K+L H +Q L R L+ LLDK +P G PS D E
Sbjct: 247 FHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKG-PSIGDIED 305
Query: 305 ETYDM---FPDTIHSRGQHGPAERTPSEIQFHQVKFGAPRRKETDP------LNEPWEEE 355
E ++ P I S + ++ ++F R ET P L P
Sbjct: 306 EEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPP---- 361
Query: 356 WTLLGKEELSGSLLQSVQEALEERSLTIRSASEFQELDSPDDTMGTIKRAPFLGPLPTDP 415
+ ++ + + L+ S ++ ++D P T PLP P
Sbjct: 362 --------------RDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPP------PLPPKP 401
Query: 416 PAEEPLSSPPGTL----------------PPPPSGPNSSPLLPTAWATMKQREDP----- 454
P PG++ PPP+ P P T+ + +P
Sbjct: 402 KFRSPSDEGPGSMGDDGQLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNP 461
Query: 455 ---ERSSCHGLPP-TPKVHMGAC--FSKVFNGCPLRIHAAVTWIHPVTRDQFLVVGAEEG 508
E LPP K+ C K+FNGCPLRIH+ W HP T+DQ L++GAEEG
Sbjct: 462 PSRELDKPPLLPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEG 521
Query: 509 IYTLNLHELHEDTLEKLISHRCSWLYCVNNVLLSLSGKSTHIWAHDLPGLFEQRRLQQQV 568
I+ LN ++ E TLE L R +W+Y +NNVL+SLSGK+ H+++H + GL E++ +
Sbjct: 522 IFILNRND-QEATLEMLFPSRTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGN 580
Query: 569 PLSIPTNRLTQRIIPRRFALSTKIPDTKGCLQCRVVRNPYTGATFLLAALPTSLLLLQWY 628
P++ + R++ R+ +STKI DTKGC C V +G FL AL TS++LLQWY
Sbjct: 581 PIA---HISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWY 637
Query: 629 EPLQKFLLLKNFSSPLPSPAGMLEPLVLDGKELPQVCVGAEGPEGPGCRVLFHVLPLEAG 688
+P+ KFLL++ PLP+P + L G ELP VC+G P PG VLFH + G
Sbjct: 638 QPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGV-SPGRPGKSVLFHT--VRFG 694
Query: 689 LTPDILIPPEGIPGSAQQVIQVDRDTILVSFERCVRIVNMQGEPTATL-APELTFDFPIE 747
L QV QV+ D ++V + V++V +G P L PE+ +E
Sbjct: 695 ALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVE 754
Query: 748 TVVCLQDSVLAFWSHGMQGRSLDTNEVTQEITDETRIFRVLGAHRDIILESIPTDNPEAH 807
V + + AFW HG+Q +L ++++ QE+ D T FR+LG+ R LE T +P H
Sbjct: 755 AVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPR---LECSGTISP--H 809
Query: 808 SNLYI 812
NL +
Sbjct: 810 CNLLL 814
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 269 bits (688), Expect = 7e-72
Identities = 154/341 (45%), Positives = 217/341 (63%), Gaps = 25/341 (7%)
Query: 1 MALLRDVSLQ----DPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDD-I 55
MA LR + Q DP + F L R+G G++G+VYK D T E+ A+KI+ L+ +D I
Sbjct: 1 MAHLRGFANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEI 60
Query: 56 SSLQQEITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAY 115
+QQEIT+L +C P + Y GSYL++ +LWI ME+ GGGS ++ GPLEE IA
Sbjct: 61 EDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKP-GPLEETYIAT 119
Query: 116 VCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTP 175
+ RE LKGL +LHS+ KIHRDIK AN+LL+ QGDVKLADFGV+G+LT + KR +F+GTP
Sbjct: 120 ILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTP 179
Query: 176 YWMAPEVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPK 235
+WMAPEV ++ Y+ D+W+LGITAIEL + +PP LHPMR L L+ K+S PP
Sbjct: 180 FWMAPEVI---KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNS--PPT 234
Query: 236 LRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPR-ALLTQLLDK----AS 290
L + + ++ F F++ L K+P+ RPTA++LL+H F T+ + + LT+L+D+ S
Sbjct: 235 L--EGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKS 292
Query: 291 DPHLGTPSPEDCELETYDMFPDTIHSRGQHGPAERTPSEIQ 331
+ H S ED ++ D G+ GP P I+
Sbjct: 293 EGHGEESSSEDSDI-------DGEAEDGEQGPIWTFPPTIR 326
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 258 bits (659), Expect = 2e-68
Identities = 133/283 (46%), Positives = 194/283 (68%), Gaps = 10/283 (3%)
Query: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDD-ISSLQQEITILR 66
++ DP + F L+R+G G++G+V+K D T ++ A+KI+ L+ +D I +QQEIT+L
Sbjct: 16 NIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLS 75
Query: 67 ECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHH 126
+C V Y GSYL+ +LWI ME+ GGGS ++ A GP +E QIA + +E LKGL +
Sbjct: 76 QCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDY 134
Query: 127 LHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVE 186
LHS+ KIHRDIK AN+LL+ QGDVKLADFGV+G+LT + KR +F+GTP+WMAPEV
Sbjct: 135 LHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI--- 191
Query: 187 RKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNF 246
++ Y+ D+W+LGITAIEL + +PP +HPMR L L+ K++ PP L +T++F
Sbjct: 192 QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNN--PPTLVGD--FTKSF 247
Query: 247 HHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPR-ALLTQLLDK 288
F+ L K+P RPTA++LL+H F + + + LT+L+D+
Sbjct: 248 KEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDR 290
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 257 bits (657), Expect = 3e-68
Identities = 138/303 (45%), Positives = 199/303 (65%), Gaps = 16/303 (5%)
Query: 11 DPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDD-ISSLQQEITILRECR 69
DP + F L+++G G++G+V+K D T ++ A+KI+ L+ +D I +QQEIT+L +C
Sbjct: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 70 HPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHLHS 129
P V Y GSYL++ +LWI ME+ GGGS ++ GPL+E QIA + RE LKGL +LHS
Sbjct: 79 SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEP-GPLDETQIATILREILKGLDYLHS 137
Query: 130 QGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKG 189
+ KIHRDIK AN+LL+ G+VKLADFGV+G+LT + KR +F+GTP+WMAPEV ++
Sbjct: 138 EKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI---KQS 194
Query: 190 GYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHF 249
Y+ D+W+LGITAIEL +PP LHPM+ L L+ K++ PP L + +++ F
Sbjct: 195 AYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNN--PPTL--EGNYSKPLKEF 250
Query: 250 LKLALTKNPKKRPTAEKLLQHPFTTQQLPR-ALLTQLLD-----KASDPHLGTPSPEDCE 303
++ L K P RPTA++LL+H F + + + LT+L+D KA H S ED +
Sbjct: 251 VEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSH-DDSSSEDSD 309
Query: 304 LET 306
ET
Sbjct: 310 AET 312
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 257 bits (657), Expect = 3e-68
Identities = 138/303 (45%), Positives = 199/303 (65%), Gaps = 16/303 (5%)
Query: 11 DPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDD-ISSLQQEITILRECR 69
DP + F L+++G G++G+V+K D T ++ A+KI+ L+ +D I +QQEIT+L +C
Sbjct: 31 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 90
Query: 70 HPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHLHS 129
P V Y GSYL++ +LWI ME+ GGGS ++ GPL+E QIA + RE LKGL +LHS
Sbjct: 91 SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEP-GPLDETQIATILREILKGLDYLHS 149
Query: 130 QGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKG 189
+ KIHRDIK AN+LL+ G+VKLADFGV+G+LT + KR +F+GTP+WMAPEV ++
Sbjct: 150 EKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI---KQS 206
Query: 190 GYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHF 249
Y+ D+W+LGITAIEL +PP LHPM+ L L+ K++ PP L + +++ F
Sbjct: 207 AYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNN--PPTL--EGNYSKPLKEF 262
Query: 250 LKLALTKNPKKRPTAEKLLQHPFTTQQLPR-ALLTQLLD-----KASDPHLGTPSPEDCE 303
++ L K P RPTA++LL+H F + + + LT+L+D KA H S ED +
Sbjct: 263 VEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSH-DDSSSEDSD 321
Query: 304 LET 306
ET
Sbjct: 322 AET 324
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 253 bits (647), Expect = 4e-67
Identities = 130/304 (42%), Positives = 193/304 (63%), Gaps = 8/304 (2%)
Query: 6 DVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITIL 65
D + P + F++L+++G G+YG VYKA T ++ A+K V ++ D+ + +EI+I+
Sbjct: 20 DSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVE--SDLQEIIKEISIM 77
Query: 66 RECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGP-LEERQIAYVCREALKGL 124
++C P+VV Y GSY +N LWI ME+CG GS+ +I L E +IA + + LKGL
Sbjct: 78 QQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGL 137
Query: 125 HHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAA 184
+LH KIHRDIK N+LL +G KLADFGV+G+LT ++AKR + IGTP+WMAPEV
Sbjct: 138 EYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI- 196
Query: 185 VERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQ 244
++ GYN + D+W+LGITAIE+ E +PP +HPMRA+ ++ + PP R W+
Sbjct: 197 --QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTN--PPPTFRKPELWSD 252
Query: 245 NFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASDPHLGTPSPEDCEL 304
NF F+K L K+P++R TA +LLQHPF ++L L+++A D L + E+
Sbjct: 253 NFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREV 312
Query: 305 ETYD 308
+ D
Sbjct: 313 DQDD 316
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 249 bits (637), Expect = 6e-66
Identities = 129/280 (46%), Positives = 184/280 (65%), Gaps = 15/280 (5%)
Query: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67
+L+DP FEL++ VG GTYG VYK R T +LAA+K++ + GD+ ++QEI +L++
Sbjct: 17 ALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKK 75
Query: 68 -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118
H N+ Y G++++ +D+LW+ MEFCG GS+ ++ T L+E IAY+CR
Sbjct: 76 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
Query: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178
E L+GL HLH IHRDIKG N+LLT +VKL DFGVS +L +V +R +FIGTPYWM
Sbjct: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236
APEV A + Y+ D+W+LGITAIE+ E PPL +HPMRAL L+ ++ P+L
Sbjct: 196 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRL 253
Query: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ 276
+ K +W++ F F++ L KN +RP E+L++HPF Q
Sbjct: 254 KSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQ 292
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 249 bits (637), Expect = 6e-66
Identities = 129/280 (46%), Positives = 184/280 (65%), Gaps = 15/280 (5%)
Query: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67
+L+DP FEL++ VG GTYG VYK R T +LAA+K++ + GD+ ++QEI +L++
Sbjct: 17 ALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKK 75
Query: 68 -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118
H N+ Y G++++ +D+LW+ MEFCG GS+ ++ T L+E IAY+CR
Sbjct: 76 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
Query: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178
E L+GL HLH IHRDIKG N+LLT +VKL DFGVS +L +V +R +FIGTPYWM
Sbjct: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236
APEV A + Y+ D+W+LGITAIE+ E PPL +HPMRAL L+ ++ P+L
Sbjct: 196 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRL 253
Query: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ 276
+ K +W++ F F++ L KN +RP E+L++HPF Q
Sbjct: 254 KSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQ 292
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 249 bits (637), Expect = 6e-66
Identities = 129/280 (46%), Positives = 184/280 (65%), Gaps = 15/280 (5%)
Query: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67
+L+DP FEL++ VG GTYG VYK R T +LAA+K++ + GD+ ++QEI +L++
Sbjct: 17 ALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKK 75
Query: 68 -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118
H N+ Y G++++ +D+LW+ MEFCG GS+ ++ T L+E IAY+CR
Sbjct: 76 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
Query: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178
E L+GL HLH IHRDIKG N+LLT +VKL DFGVS +L +V +R +FIGTPYWM
Sbjct: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236
APEV A + Y+ D+W+LGITAIE+ E PPL +HPMRAL L+ ++ P+L
Sbjct: 196 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRL 253
Query: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ 276
+ K +W++ F F++ L KN +RP E+L++HPF Q
Sbjct: 254 KSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQ 292
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 249 bits (637), Expect = 6e-66
Identities = 129/280 (46%), Positives = 184/280 (65%), Gaps = 15/280 (5%)
Query: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67
+L+DP FEL++ VG GTYG VYK R T +LAA+K++ + GD+ ++QEI +L++
Sbjct: 17 ALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKK 75
Query: 68 -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118
H N+ Y G++++ +D+LW+ MEFCG GS+ ++ T L+E IAY+CR
Sbjct: 76 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
Query: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178
E L+GL HLH IHRDIKG N+LLT +VKL DFGVS +L +V +R +FIGTPYWM
Sbjct: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236
APEV A + Y+ D+W+LGITAIE+ E PPL +HPMRAL L+ ++ P+L
Sbjct: 196 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRL 253
Query: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ 276
+ K +W++ F F++ L KN +RP E+L++HPF Q
Sbjct: 254 KSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQ 292
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 249 bits (637), Expect = 6e-66
Identities = 129/280 (46%), Positives = 184/280 (65%), Gaps = 15/280 (5%)
Query: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67
+L+DP FEL++ VG GTYG VYK R T +LAA+K++ + GD+ ++QEI +L++
Sbjct: 17 ALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKK 75
Query: 68 -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118
H N+ Y G++++ +D+LW+ MEFCG GS+ ++ T L+E IAY+CR
Sbjct: 76 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
Query: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178
E L+GL HLH IHRDIKG N+LLT +VKL DFGVS +L +V +R +FIGTPYWM
Sbjct: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236
APEV A + Y+ D+W+LGITAIE+ E PPL +HPMRAL L+ ++ P+L
Sbjct: 196 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRL 253
Query: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ 276
+ K +W++ F F++ L KN +RP E+L++HPF Q
Sbjct: 254 KSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQ 292
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 249 bits (637), Expect = 6e-66
Identities = 129/280 (46%), Positives = 184/280 (65%), Gaps = 15/280 (5%)
Query: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67
+L+DP FEL++ VG GTYG VYK R T +LAA+K++ + GD+ ++QEI +L++
Sbjct: 17 ALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKK 75
Query: 68 -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118
H N+ Y G++++ +D+LW+ MEFCG GS+ ++ T L+E IAY+CR
Sbjct: 76 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
Query: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178
E L+GL HLH IHRDIKG N+LLT +VKL DFGVS +L +V +R +FIGTPYWM
Sbjct: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236
APEV A + Y+ D+W+LGITAIE+ E PPL +HPMRAL L+ ++ P+L
Sbjct: 196 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRL 253
Query: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ 276
+ K +W++ F F++ L KN +RP E+L++HPF Q
Sbjct: 254 KSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQ 292
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 249 bits (637), Expect = 6e-66
Identities = 129/280 (46%), Positives = 184/280 (65%), Gaps = 15/280 (5%)
Query: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67
+L+DP FEL++ VG GTYG VYK R T +LAA+K++ + GD+ ++QEI +L++
Sbjct: 17 ALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKK 75
Query: 68 -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118
H N+ Y G++++ +D+LW+ MEFCG GS+ ++ T L+E IAY+CR
Sbjct: 76 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
Query: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178
E L+GL HLH IHRDIKG N+LLT +VKL DFGVS +L +V +R +FIGTPYWM
Sbjct: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236
APEV A + Y+ D+W+LGITAIE+ E PPL +HPMRAL L+ ++ P+L
Sbjct: 196 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRL 253
Query: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ 276
+ K +W++ F F++ L KN +RP E+L++HPF Q
Sbjct: 254 KSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQ 292
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 249 bits (637), Expect = 6e-66
Identities = 129/280 (46%), Positives = 184/280 (65%), Gaps = 15/280 (5%)
Query: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67
+L+DP FEL++ VG GTYG VYK R T +LAA+K++ + GD+ ++QEI +L++
Sbjct: 17 ALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKK 75
Query: 68 -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118
H N+ Y G++++ +D+LW+ MEFCG GS+ ++ T L+E IAY+CR
Sbjct: 76 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
Query: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178
E L+GL HLH IHRDIKG N+LLT +VKL DFGVS +L +V +R +FIGTPYWM
Sbjct: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236
APEV A + Y+ D+W+LGITAIE+ E PPL +HPMRAL L+ ++ P+L
Sbjct: 196 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRL 253
Query: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ 276
+ K +W++ F F++ L KN +RP E+L++HPF Q
Sbjct: 254 KSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQ 292
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 248 bits (632), Expect = 2e-65
Identities = 128/304 (42%), Positives = 191/304 (62%), Gaps = 8/304 (2%)
Query: 3 LLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEI 62
L D + P + F++L+++G G+YG V+KA + ++ A+K V ++ D+ + +EI
Sbjct: 14 LSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE--SDLQEIIKEI 71
Query: 63 TILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGP-LEERQIAYVCREAL 121
+I+++C P VV Y GSY +N LWI ME+CG GS+ +I L E +IA + + L
Sbjct: 72 SIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTL 131
Query: 122 KGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPE 181
KGL +LH KIHRDIK N+LL +G KLADFGV+G+LT ++AKR + IGTP+WMAPE
Sbjct: 132 KGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 191
Query: 182 VAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTR 241
V ++ GYN + D+W+LGIT+IE+ E +PP +HPMRA+ ++ + PP R
Sbjct: 192 VI---QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTN--PPPTFRKPEL 246
Query: 242 WTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASDPHLGTPSPED 301
W+ +F F+K L KNP++R TA +LLQHPF P ++L L+ +A + +
Sbjct: 247 WSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQ 306
Query: 302 CELE 305
ELE
Sbjct: 307 RELE 310
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 243 bits (621), Expect = 4e-64
Identities = 139/326 (42%), Positives = 196/326 (60%), Gaps = 17/326 (5%)
Query: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67
+L+DP FEL++ VG GTYG VYK R T +LAA+K++ + D+ ++QEI +L++
Sbjct: 17 ALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEEEEIKQEINMLKK 75
Query: 68 -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118
H N+ Y G++++ +D+LW+ MEFCG GS+ ++ T L+E IAY+CR
Sbjct: 76 YSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICR 135
Query: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178
E L+GL HLH+ IHRDIKG N+LLT +VKL DFGVS +L +V +R +FIGTPYWM
Sbjct: 136 EILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236
APEV A + Y+ D+W+LGITAIE+ E PPL +HPMRAL L+ ++ PP+L
Sbjct: 196 APEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRL 253
Query: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ-LPRALLTQLLDKASDPHLG 295
+ K +W++ F F+ L K RP E+LL+ PF Q R + QL D
Sbjct: 254 KSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKK 312
Query: 296 TPSPEDCELETYDMFPDTIHSRGQHG 321
E+ E E Y + S G+ G
Sbjct: 313 RGEKEETEYE-YSGSEEEDDSHGEEG 337
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 243 bits (621), Expect = 4e-64
Identities = 139/326 (42%), Positives = 196/326 (60%), Gaps = 17/326 (5%)
Query: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67
+L+DP FEL++ VG GTYG VYK R T +LAA+K++ + D+ ++QEI +L++
Sbjct: 17 ALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEEEEIKQEINMLKK 75
Query: 68 -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118
H N+ Y G++++ +D+LW+ MEFCG GS+ ++ T L+E IAY+CR
Sbjct: 76 YSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICR 135
Query: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178
E L+GL HLH+ IHRDIKG N+LLT +VKL DFGVS +L +V +R +FIGTPYWM
Sbjct: 136 EILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236
APEV A + Y+ D+W+LGITAIE+ E PPL +HPMRAL L+ ++ PP+L
Sbjct: 196 APEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRL 253
Query: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ-LPRALLTQLLDKASDPHLG 295
+ K +W++ F F+ L K RP E+LL+ PF Q R + QL D
Sbjct: 254 KSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKK 312
Query: 296 TPSPEDCELETYDMFPDTIHSRGQHG 321
E+ E E Y + S G+ G
Sbjct: 313 RGEKEETEYE-YSGSEEEDDSHGEEG 337
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 243 bits (621), Expect = 4e-64
Identities = 139/326 (42%), Positives = 196/326 (60%), Gaps = 17/326 (5%)
Query: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67
+L+DP FEL++ VG GTYG VYK R T +LAA+K++ + D+ ++QEI +L++
Sbjct: 17 ALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEEEEIKQEINMLKK 75
Query: 68 -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118
H N+ Y G++++ +D+LW+ MEFCG GS+ ++ T L+E IAY+CR
Sbjct: 76 YSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICR 135
Query: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178
E L+GL HLH+ IHRDIKG N+LLT +VKL DFGVS +L +V +R +FIGTPYWM
Sbjct: 136 EILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236
APEV A + Y+ D+W+LGITAIE+ E PPL +HPMRAL L+ ++ PP+L
Sbjct: 196 APEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRL 253
Query: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ-LPRALLTQLLDKASDPHLG 295
+ K +W++ F F+ L K RP E+LL+ PF Q R + QL D
Sbjct: 254 KSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKK 312
Query: 296 TPSPEDCELETYDMFPDTIHSRGQHG 321
E+ E E Y + S G+ G
Sbjct: 313 RGEKEETEYE-YSGSEEEDDSHGEEG 337
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 243 bits (621), Expect = 4e-64
Identities = 139/326 (42%), Positives = 196/326 (60%), Gaps = 17/326 (5%)
Query: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67
+L+DP FEL++ VG GTYG VYK R T +LAA+K++ + D+ ++QEI +L++
Sbjct: 17 ALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEEEEIKQEINMLKK 75
Query: 68 -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118
H N+ Y G++++ +D+LW+ MEFCG GS+ ++ T L+E IAY+CR
Sbjct: 76 YSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICR 135
Query: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178
E L+GL HLH+ IHRDIKG N+LLT +VKL DFGVS +L +V +R +FIGTPYWM
Sbjct: 136 EILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236
APEV A + Y+ D+W+LGITAIE+ E PPL +HPMRAL L+ ++ PP+L
Sbjct: 196 APEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRL 253
Query: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ-LPRALLTQLLDKASDPHLG 295
+ K +W++ F F+ L K RP E+LL+ PF Q R + QL D
Sbjct: 254 KSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKK 312
Query: 296 TPSPEDCELETYDMFPDTIHSRGQHG 321
E+ E E Y + S G+ G
Sbjct: 313 RGEKEETEYE-YSGSEEEDDSHGEEG 337
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 243 bits (619), Expect = 7e-64
Identities = 122/282 (43%), Positives = 181/282 (64%), Gaps = 5/282 (1%)
Query: 11 DPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRH 70
DP + +E++ +G G +G VYKA++ T LAA K+++ +++ EI IL C H
Sbjct: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDH 90
Query: 71 PNVVAYIGSYLRNDRLWICMEFCGGGSLQEIY-HATGPLEERQIAYVCREALKGLHHLHS 129
P +V +G+Y + +LWI +EFC GG++ I L E QI VCR+ L+ L+ LHS
Sbjct: 91 PYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHS 150
Query: 130 QGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVE--R 187
+ IHRD+K N+L+TL+GD++LADFGVS + ++ KR SFIGTPYWMAPEV E +
Sbjct: 151 KRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMK 210
Query: 188 KGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFH 247
Y+ D+W+LGIT IE+ +++PP L+PMR L+ ++KS PP L ++W+ F
Sbjct: 211 DTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKS--DPPTLLTPSKWSVEFR 268
Query: 248 HFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKA 289
FLK+AL KNP+ RP+A +LL+HPF + L +L+ +A
Sbjct: 269 DFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEA 310
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 242 bits (618), Expect = 9e-64
Identities = 127/306 (41%), Positives = 182/306 (59%), Gaps = 7/306 (2%)
Query: 11 DPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRH 70
+P D +E++ +G G +G VYKA++ TS LAA K++ +++ EI IL C H
Sbjct: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88
Query: 71 PNVVAYIGSYLRNDRLWICMEFCGGGSLQEIY-HATGPLEERQIAYVCREALKGLHHLHS 129
PN+V + ++ + LWI +EFC GG++ + PL E QI VC++ L L++LH
Sbjct: 89 PNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHD 148
Query: 130 QGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVE--R 187
IHRD+K N+L TL GD+KLADFGVS + T ++ +R SFIGTPYWMAPEV E +
Sbjct: 149 NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSK 208
Query: 188 KGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFH 247
Y+ DVW+LGIT IE+ E++PP L+PMR L+ ++KS +PP L +RW+ NF
Sbjct: 209 DRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKS--EPPTLAQPSRWSSNFK 266
Query: 248 HFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASD--PHLGTPSPEDCELE 305
FLK L KN R T +LLQHPF T + + + + ++ + ED E E
Sbjct: 267 DFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKEEDEEEE 326
Query: 306 TYDMFP 311
T + P
Sbjct: 327 TENSLP 332
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 241 bits (616), Expect = 2e-63
Identities = 149/401 (37%), Positives = 224/401 (55%), Gaps = 22/401 (5%)
Query: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67
SL+DP FEL++ VG GTYG VYK R T +LAA+K++ + D+ ++ EI +L++
Sbjct: 17 SLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEEEEIKLEINMLKK 75
Query: 68 -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118
H N+ Y G++++ +D+LW+ MEFCG GS+ ++ T L+E IAY+ R
Sbjct: 76 YSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISR 135
Query: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178
E L+GL HLH IHRDIKG N+LLT +VKL DFGVS +L +V +R +FIGTPYWM
Sbjct: 136 EILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236
APEV A + Y+ D+W+ GITAIE+ E PPL +HPMRAL L+ ++ PP+L
Sbjct: 196 APEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRL 253
Query: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ-LPRALLTQLLDKASDPHLG 295
+ K +W++ F F++ L KN +RP+ E+LL+HPF Q R + QL D
Sbjct: 254 KSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKK 312
Query: 296 TPSPEDCELE---TYDMFPDTIHSRGQHGPAERTPSEIQFHQ--VKFGAPRRKETDPL-N 349
++ E E + + + G+ P E + ++ ++ ++ L
Sbjct: 313 RGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRR 372
Query: 350 EPWEEEWTLLGKEELSGSLLQSVQEALEERSLTIRSASEFQ 390
+ +E L +EE LL Q+ +E++ R E Q
Sbjct: 373 QQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQ 413
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 241 bits (616), Expect = 2e-63
Identities = 149/401 (37%), Positives = 224/401 (55%), Gaps = 22/401 (5%)
Query: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67
SL+DP FEL++ VG GTYG VYK R T +LAA+K++ + D+ ++ EI +L++
Sbjct: 17 SLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEEEEIKLEINMLKK 75
Query: 68 -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118
H N+ Y G++++ +D+LW+ MEFCG GS+ ++ T L+E IAY+ R
Sbjct: 76 YSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISR 135
Query: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178
E L+GL HLH IHRDIKG N+LLT +VKL DFGVS +L +V +R +FIGTPYWM
Sbjct: 136 EILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236
APEV A + Y+ D+W+ GITAIE+ E PPL +HPMRAL L+ ++ PP+L
Sbjct: 196 APEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRL 253
Query: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ-LPRALLTQLLDKASDPHLG 295
+ K +W++ F F++ L KN +RP+ E+LL+HPF Q R + QL D
Sbjct: 254 KSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKK 312
Query: 296 TPSPEDCELE---TYDMFPDTIHSRGQHGPAERTPSEIQFHQ--VKFGAPRRKETDPL-N 349
++ E E + + + G+ P E + ++ ++ ++ L
Sbjct: 313 RGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRR 372
Query: 350 EPWEEEWTLLGKEELSGSLLQSVQEALEERSLTIRSASEFQ 390
+ +E L +EE LL Q+ +E++ R E Q
Sbjct: 373 QQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQ 413
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 241 bits (616), Expect = 2e-63
Identities = 149/401 (37%), Positives = 224/401 (55%), Gaps = 22/401 (5%)
Query: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67
SL+DP FEL++ VG GTYG VYK R T +LAA+K++ + D+ ++ EI +L++
Sbjct: 17 SLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEEEEIKLEINMLKK 75
Query: 68 -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118
H N+ Y G++++ +D+LW+ MEFCG GS+ ++ T L+E IAY+ R
Sbjct: 76 YSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISR 135
Query: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178
E L+GL HLH IHRDIKG N+LLT +VKL DFGVS +L +V +R +FIGTPYWM
Sbjct: 136 EILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236
APEV A + Y+ D+W+ GITAIE+ E PPL +HPMRAL L+ ++ PP+L
Sbjct: 196 APEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRL 253
Query: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ-LPRALLTQLLDKASDPHLG 295
+ K +W++ F F++ L KN +RP+ E+LL+HPF Q R + QL D
Sbjct: 254 KSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKK 312
Query: 296 TPSPEDCELE---TYDMFPDTIHSRGQHGPAERTPSEIQFHQ--VKFGAPRRKETDPL-N 349
++ E E + + + G+ P E + ++ ++ ++ L
Sbjct: 313 RGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRR 372
Query: 350 EPWEEEWTLLGKEELSGSLLQSVQEALEERSLTIRSASEFQ 390
+ +E L +EE LL Q+ +E++ R E Q
Sbjct: 373 QQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQ 413
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 238 bits (606), Expect = 2e-62
Identities = 130/278 (46%), Positives = 174/278 (62%), Gaps = 17/278 (6%)
Query: 11 DPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISS-LQQEITILRECR 69
DP D +E+ + +G GTYG V+K + + AAVKI LDP DI ++ E IL+
Sbjct: 16 DPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKI--LDPIHDIDEEIEAEYNILKALS 73
Query: 70 -HPNVVAYIGSYLRNDR-----LWICMEFCGGGSLQEIYHATGPLEERQ----IAYVCRE 119
HPNVV + G Y + D+ LW+ +E C GGS+ ++ ER IAY+ E
Sbjct: 74 DHPNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHE 133
Query: 120 ALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMA 179
AL GL HLH+ IHRD+KG N+LLT +G VKL DFGVS +LT++ +R + +GTP+WMA
Sbjct: 134 ALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMA 193
Query: 180 PEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLR 237
PEV A E++ Y+ CD W+LGITAIELG+ PPL LHPMRAL + ++ PPKLR
Sbjct: 194 PEVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRN--PPPKLR 251
Query: 238 DKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQ 275
W+ F+ F+ LTK+ +KRPT +LLQH F TQ
Sbjct: 252 QPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQ 289
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,936,351
Number of Sequences: 37866
Number of extensions: 2034179
Number of successful extensions: 16434
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 763
Number of HSP's successfully gapped in prelim test: 418
Number of HSP's that attempted gapping in prelim test: 11031
Number of HSP's gapped (non-prelim): 3685
length of query: 820
length of database: 18,247,518
effective HSP length: 111
effective length of query: 709
effective length of database: 14,044,392
effective search space: 9957473928
effective search space used: 9957473928
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.