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Search of human proteins with 115298645
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|115298645 mitogen-activated protein kinase kinase kinase 14
[Homo sapiens]
(947 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|115298645 mitogen-activated protein kinase kinase kinase 14 [... 1950 0.0
gi|22035598 mitogen-activated protein kinase kinase kinase 8 [Ho... 131 3e-30
gi|153945765 mitogen-activated protein kinase kinase kinase 1 [H... 125 2e-28
gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Ho... 124 4e-28
gi|42794767 mitogen-activated protein kinase kinase kinase 3 iso... 117 5e-26
gi|42794765 mitogen-activated protein kinase kinase kinase 3 iso... 117 5e-26
gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens] 110 8e-24
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens] 110 8e-24
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 108 2e-23
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 108 3e-23
gi|32483399 p21-activated kinase 2 [Homo sapiens] 107 4e-23
gi|45827809 mitogen-activated protein kinase kinase kinase 6 [Ho... 107 4e-23
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 105 3e-22
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 105 3e-22
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 104 4e-22
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens] 103 6e-22
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens] 103 6e-22
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens] 103 6e-22
gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens] 103 6e-22
gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens] 103 6e-22
gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens] 103 6e-22
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 101 4e-21
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 100 1e-20
gi|121583542 mitogen-activated protein kinase kinase kinase 15 [... 98 4e-20
gi|191252782 p21-activated kinase 6 [Homo sapiens] 97 5e-20
gi|191252780 p21-activated kinase 6 [Homo sapiens] 97 5e-20
gi|9910476 p21-activated kinase 6 [Homo sapiens] 97 5e-20
gi|21359873 polo-like kinase 1 [Homo sapiens] 97 7e-20
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 97 7e-20
gi|29826329 p21-activated kinase 7 [Homo sapiens] 97 9e-20
>gi|115298645 mitogen-activated protein kinase kinase kinase 14
[Homo sapiens]
Length = 947
Score = 1950 bits (5051), Expect = 0.0
Identities = 947/947 (100%), Positives = 947/947 (100%)
Query: 1 MAVMEMACPGAPGSAVGQQKELPKAKEKTPPLGKKQSSVYKLEAVEKSPVFCGKWEILND 60
MAVMEMACPGAPGSAVGQQKELPKAKEKTPPLGKKQSSVYKLEAVEKSPVFCGKWEILND
Sbjct: 1 MAVMEMACPGAPGSAVGQQKELPKAKEKTPPLGKKQSSVYKLEAVEKSPVFCGKWEILND 60
Query: 61 VITKGTAKEGSEAGPAAISIIAQAECENSQEFSPTFSERIFIAGSKQYSQSESLDQIPNN 120
VITKGTAKEGSEAGPAAISIIAQAECENSQEFSPTFSERIFIAGSKQYSQSESLDQIPNN
Sbjct: 61 VITKGTAKEGSEAGPAAISIIAQAECENSQEFSPTFSERIFIAGSKQYSQSESLDQIPNN 120
Query: 121 VAHATEGKMARVCWKGKRRSKARKKRKKKSSKSLAHAGVALAKPLPRTPEQESCTIPVQE 180
VAHATEGKMARVCWKGKRRSKARKKRKKKSSKSLAHAGVALAKPLPRTPEQESCTIPVQE
Sbjct: 121 VAHATEGKMARVCWKGKRRSKARKKRKKKSSKSLAHAGVALAKPLPRTPEQESCTIPVQE 180
Query: 181 DESPLGAPYVRNTPQFTKPLKEPGLGQLCFKQLGEGLRPALPRSELHKLISPLQCLNHVW 240
DESPLGAPYVRNTPQFTKPLKEPGLGQLCFKQLGEGLRPALPRSELHKLISPLQCLNHVW
Sbjct: 181 DESPLGAPYVRNTPQFTKPLKEPGLGQLCFKQLGEGLRPALPRSELHKLISPLQCLNHVW 240
Query: 241 KLHHPQDGGPLPLPTHPFPYSRLPHPFPFHPLQPWKPHPLESFLGKLACVDSQKPLPDPH 300
KLHHPQDGGPLPLPTHPFPYSRLPHPFPFHPLQPWKPHPLESFLGKLACVDSQKPLPDPH
Sbjct: 241 KLHHPQDGGPLPLPTHPFPYSRLPHPFPFHPLQPWKPHPLESFLGKLACVDSQKPLPDPH 300
Query: 301 LSKLACVDSPKPLPGPHLEPSCLSRGAHEKFSVEEYLVHALQGSVSSGQAHSLTSLAKTW 360
LSKLACVDSPKPLPGPHLEPSCLSRGAHEKFSVEEYLVHALQGSVSSGQAHSLTSLAKTW
Sbjct: 301 LSKLACVDSPKPLPGPHLEPSCLSRGAHEKFSVEEYLVHALQGSVSSGQAHSLTSLAKTW 360
Query: 361 AARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDK 420
AARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDK
Sbjct: 361 AARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDK 420
Query: 421 QTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQL 480
QTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQL
Sbjct: 421 QTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQL 480
Query: 481 VKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVC 540
VKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVC
Sbjct: 481 VKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVC 540
Query: 541 LQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFF 600
LQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFF
Sbjct: 541 LQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFF 600
Query: 601 RGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGG 660
RGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGG
Sbjct: 601 RGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGG 660
Query: 661 LKSPWRGEYKEPRHPPPNQANYHQTLHAQPRELSPRAPGPRPAEETTGRAPKLQPPLPPE 720
LKSPWRGEYKEPRHPPPNQANYHQTLHAQPRELSPRAPGPRPAEETTGRAPKLQPPLPPE
Sbjct: 661 LKSPWRGEYKEPRHPPPNQANYHQTLHAQPRELSPRAPGPRPAEETTGRAPKLQPPLPPE 720
Query: 721 PPEPNKSPPLTLSKEESGMWEPLPLSSLEPAPARNPSSPERKATVPEQELQQLEIELFLN 780
PPEPNKSPPLTLSKEESGMWEPLPLSSLEPAPARNPSSPERKATVPEQELQQLEIELFLN
Sbjct: 721 PPEPNKSPPLTLSKEESGMWEPLPLSSLEPAPARNPSSPERKATVPEQELQQLEIELFLN 780
Query: 781 SLSQPFSLEEQEQILSCLSIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSWSSQAEARSS 840
SLSQPFSLEEQEQILSCLSIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSWSSQAEARSS
Sbjct: 781 SLSQPFSLEEQEQILSCLSIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSWSSQAEARSS 840
Query: 841 SWNMVLARGRPTDTPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPAAAFS 900
SWNMVLARGRPTDTPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPAAAFS
Sbjct: 841 SWNMVLARGRPTDTPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPAAAFS 900
Query: 901 LVTKDGQPVRYDMEVPDSGIDLQCTLAPDGSFAWSWRVKHGQLENRP 947
LVTKDGQPVRYDMEVPDSGIDLQCTLAPDGSFAWSWRVKHGQLENRP
Sbjct: 901 LVTKDGQPVRYDMEVPDSGIDLQCTLAPDGSFAWSWRVKHGQLENRP 947
>gi|22035598 mitogen-activated protein kinase kinase kinase 8 [Homo
sapiens]
Length = 467
Score = 131 bits (329), Expect = 3e-30
Identities = 86/283 (30%), Positives = 146/283 (51%), Gaps = 21/283 (7%)
Query: 379 GVLLTEKLKPVDYEYREE-----VHWATHQLRLG-----RGSFGEVHRMEDKQTGFQCAV 428
G+LL + P + Y+ + + W +G RG+FG+V+ +D +T + A
Sbjct: 107 GILLNMVITPQNGRYQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMAC 166
Query: 429 KKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLP 488
K + ++ F+ ++ A I LYGAV G V++FME EGGS+ + ++ G +
Sbjct: 167 KLIPVDQFKPSDVEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMR 226
Query: 489 EDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGK 548
E ++ L+GL++LHS++++H D+K N++ S + A L DFG +V + D
Sbjct: 227 EFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMS--TKAVLVDFGLSVQMTED---- 280
Query: 549 SLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFF---RGPLC 605
+ + GTE +M+PEV+L R K D++S ++HM G PW + + P
Sbjct: 281 -VYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSY 339
Query: 606 LKIA-SEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAEL 647
L I + PP+ +I C+P + I+ L + P HR AA+L
Sbjct: 340 LYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADL 382
>gi|153945765 mitogen-activated protein kinase kinase kinase 1 [Homo
sapiens]
Length = 1512
Score = 125 bits (314), Expect = 2e-28
Identities = 94/308 (30%), Positives = 135/308 (43%), Gaps = 36/308 (11%)
Query: 370 PSPKTEDNEGVLLTEKLKP--------VDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQ 421
P + E+ E +++ ++ P YRE+ W Q ++G G+F ++ +D
Sbjct: 1206 PQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQ-QIGLGAFSSCYQAQDVG 1264
Query: 422 TGFQCAVKKVRL---------EVFRA--EELMACAGLTSPRIVPLYGAVREGPWVNIFME 470
TG AVK+V EV A EE+ + L P I+ + GA E N+F+E
Sbjct: 1265 TGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIE 1324
Query: 471 LLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHA 530
+ GGS+ L+ + G E + Y Q L GL YLH +I+H DVK N+L+ S G
Sbjct: 1325 WMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRL 1384
Query: 531 ALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHML 590
+ DFG A L G G G + GT MAPEV+ G+ DVWS C ++ M
Sbjct: 1385 RIADFGAAARLASKGTGAGEFQGQLL-GTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMA 1443
Query: 591 NGCHPWTQFFRG---PLCLKIASE----------PPPVREIPPSCAPLTAQ--AIQEGLR 635
PW L KIAS P +R++ C L Q L
Sbjct: 1444 CAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELL 1503
Query: 636 KEPIHRVS 643
K P+ R +
Sbjct: 1504 KHPVFRTT 1511
>gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Homo
sapiens]
Length = 619
Score = 124 bits (311), Expect = 4e-28
Identities = 91/279 (32%), Positives = 132/279 (47%), Gaps = 28/279 (10%)
Query: 386 LKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE------ 439
+ P R +W +L LG+G+FG V+ D TG + AVK+V+ + E
Sbjct: 343 ISPPSRSPRAPTNWRLGKL-LGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVN 401
Query: 440 ----ELMACAGLTSPRIVPLYGAVREGP--WVNIFMELLEGGSLGQLVKEQGCLPEDRAL 493
E+ L RIV YG +R+ ++IFME + GGS+ +K G L E+
Sbjct: 402 ALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTR 461
Query: 494 YYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFG-----HAVCLQPDGLGK 548
Y Q LEG+ YLHS I+H D+K N+L S G + L DFG +CL G+
Sbjct: 462 KYTRQILEGVHYLHSNMIVHRDIKGANILRDSTG-NVKLGDFGASKRLQTICLSGTGMKS 520
Query: 549 SLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKI 608
+ GT M+PEV+ G K D+WS C ++ ML PW +F KI
Sbjct: 521 -------VTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKI 573
Query: 609 ASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAEL 647
A++P + +PP + T ++ + E R SA EL
Sbjct: 574 ATQPTNPK-LPPHVSDYTRDFLKR-IFVEAKLRPSADEL 610
>gi|42794767 mitogen-activated protein kinase kinase kinase 3
isoform 1 [Homo sapiens]
Length = 657
Score = 117 bits (293), Expect = 5e-26
Identities = 81/257 (31%), Positives = 120/257 (46%), Gaps = 26/257 (10%)
Query: 373 KTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVR 432
++ D+E L ++ ++W +L LG+G+FG V+ D TG + A K+V+
Sbjct: 367 RSADSENALSVQERNVPTKSPSAPINWRRGKL-LGQGAFGRVYLCYDVDTGRELASKQVQ 425
Query: 433 LEVFRAE----------ELMACAGLTSPRIVPLYGAVREGP--WVNIFMELLEGGSLGQL 480
+ E E+ L RIV YG +R+ + IFME + GGS+
Sbjct: 426 FDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQ 485
Query: 481 VKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFG---- 536
+K G L E Y Q LEG+ YLHS I+H D+K N+L S G + L DFG
Sbjct: 486 LKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAG-NVKLGDFGASKR 544
Query: 537 -HAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHP 595
+C+ G+ + GT M+PEV+ G K DVWS C ++ ML P
Sbjct: 545 LQTICMSGTGMRS-------VTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPP 597
Query: 596 WTQFFRGPLCLKIASEP 612
W ++ KIA++P
Sbjct: 598 WAEYEAMAAIFKIATQP 614
>gi|42794765 mitogen-activated protein kinase kinase kinase 3
isoform 2 [Homo sapiens]
Length = 626
Score = 117 bits (293), Expect = 5e-26
Identities = 81/257 (31%), Positives = 120/257 (46%), Gaps = 26/257 (10%)
Query: 373 KTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVR 432
++ D+E L ++ ++W +L LG+G+FG V+ D TG + A K+V+
Sbjct: 336 RSADSENALSVQERNVPTKSPSAPINWRRGKL-LGQGAFGRVYLCYDVDTGRELASKQVQ 394
Query: 433 LEVFRAE----------ELMACAGLTSPRIVPLYGAVREGP--WVNIFMELLEGGSLGQL 480
+ E E+ L RIV YG +R+ + IFME + GGS+
Sbjct: 395 FDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQ 454
Query: 481 VKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFG---- 536
+K G L E Y Q LEG+ YLHS I+H D+K N+L S G + L DFG
Sbjct: 455 LKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAG-NVKLGDFGASKR 513
Query: 537 -HAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHP 595
+C+ G+ + GT M+PEV+ G K DVWS C ++ ML P
Sbjct: 514 LQTICMSGTGMRS-------VTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPP 566
Query: 596 WTQFFRGPLCLKIASEP 612
W ++ KIA++P
Sbjct: 567 WAEYEAMAAIFKIATQP 583
>gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]
Length = 553
Score = 110 bits (274), Expect = 8e-24
Identities = 86/290 (29%), Positives = 137/290 (47%), Gaps = 16/290 (5%)
Query: 363 RGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQT 422
R + ++ PK D E + EKL+ + + T ++G+G+ G V+ D T
Sbjct: 237 RNTEKQKKKPKMSDEE---ILEKLRSI-VSVGDPKKKYTRFEKIGQGASGTVYTAMDVAT 292
Query: 423 GFQCAVKKVRLEVFRAEELMACAGLT-----SPRIVPLYGAVREGPWVNIFMELLEGGSL 477
G + A+K++ L+ +EL+ L +P IV + G + + ME L GGSL
Sbjct: 293 GQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 352
Query: 478 GQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGH 537
+V E C+ E + + L+ LE+LHS +++H D+K+DN+LL DGS L DFG
Sbjct: 353 TDVVTET-CMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGS-VKLTDFGF 410
Query: 538 AVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWT 597
+ P+ +S + GT MAPEVV ++ KVD+WS M + M+ G P+
Sbjct: 411 CAQITPEQSKRSTMV-----GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYL 465
Query: 598 QFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAEL 647
IA+ P + P + + + L + R SA EL
Sbjct: 466 NENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKEL 515
>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
Length = 545
Score = 110 bits (274), Expect = 8e-24
Identities = 86/290 (29%), Positives = 137/290 (47%), Gaps = 16/290 (5%)
Query: 363 RGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQT 422
R + ++ PK D E + EKL+ + + T ++G+G+ G V+ D T
Sbjct: 237 RNTEKQKKKPKMSDEE---ILEKLRSI-VSVGDPKKKYTRFEKIGQGASGTVYTAMDVAT 292
Query: 423 GFQCAVKKVRLEVFRAEELMACAGLT-----SPRIVPLYGAVREGPWVNIFMELLEGGSL 477
G + A+K++ L+ +EL+ L +P IV + G + + ME L GGSL
Sbjct: 293 GQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 352
Query: 478 GQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGH 537
+V E C+ E + + L+ LE+LHS +++H D+K+DN+LL DGS L DFG
Sbjct: 353 TDVVTET-CMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGS-VKLTDFGF 410
Query: 538 AVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWT 597
+ P+ +S + GT MAPEVV ++ KVD+WS M + M+ G P+
Sbjct: 411 CAQITPEQSKRSTMV-----GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYL 465
Query: 598 QFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAEL 647
IA+ P + P + + + L + R SA EL
Sbjct: 466 NENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKEL 515
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 108 bits (271), Expect = 2e-23
Identities = 80/249 (32%), Positives = 122/249 (48%), Gaps = 14/249 (5%)
Query: 405 RLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE---ELMACAGLTSPRIVPLYGAVRE 461
+LG GS+G V++ K+TG A+K+V +E E E+ SP +V YG+ +
Sbjct: 35 KLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFK 94
Query: 462 GPWVNIFMELLEGGSLGQLVKEQG-CLPEDRALYYLGQALEGLEYLHSRRILHGDVKADN 520
+ I ME GS+ +++ + L ED L L+GLEYLH R +H D+KA N
Sbjct: 95 NTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGN 154
Query: 521 VLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVV--LGRSCDAKVD 578
+LL+++G HA L DFG A L ++ + + GT MAPEV+ +G +C A D
Sbjct: 155 ILLNTEG-HAKLADFGVA-----GQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVA--D 206
Query: 579 VWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEP 638
+WS + M G P+ I + PPP P + +++ L K P
Sbjct: 207 IWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSP 266
Query: 639 IHRVSAAEL 647
R +A +L
Sbjct: 267 EQRATATQL 275
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 108 bits (269), Expect = 3e-23
Identities = 114/404 (28%), Positives = 176/404 (43%), Gaps = 50/404 (12%)
Query: 406 LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE--------ELMACAGLTSPRIVPLYG 457
+G GSFG V++ K + A+K + ++ R+E E+ GL P IV +
Sbjct: 10 IGEGSFGRVYKGRRKYSAQVVALKFIP-KLGRSEKELRNLQREIEIMRGLRHPNIVHMLD 68
Query: 458 AVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVK 517
+ V + + EG L Q++++ G LPED+ Q + L YLHS RILH D+K
Sbjct: 69 SFETDKEVVVVTDYAEG-ELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRILHRDMK 127
Query: 518 ADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKV 577
N+LL+ G LCDFG A + + + +LT I GT +M+PE+V R D
Sbjct: 128 PQNILLAKGGG-IKLCDFGFARAMSTNTM---VLTS--IKGTPLYMSPELVEERPYDHTA 181
Query: 578 DVWSSCCMMLHMLNGCHPW--TQFFR-GPLCLKIASEPPPVREIPPSCAPLTAQAIQEGL 634
D+WS C++ + G P+ T F+ L LK PVR P + +P +Q L
Sbjct: 182 DLWSVGCILYELAVGTPPFYATSIFQLVSLILK-----DPVR-WPSTISPCFKNFLQGLL 235
Query: 635 RKEPIHRVSAAEL------GGKVNRALQQVG-GLKSPW-----------RGEYKEPRHPP 676
K+P R+S +L G V + G L +P+ + E P
Sbjct: 236 TKDPRQRLSWPDLLYHPFIAGHVTIITEPAGPDLGTPFTSRLPPELQVLKDEQAHRLAPK 295
Query: 677 PNQANYHQTLHAQPRE--LSPRAPGPRPAEETTGRAPKLQP---PLPPEPPEPNKSPPLT 731
NQ+ + + E + + PA E + K+ P PLP P +S L
Sbjct: 296 GNQSRILTQAYKRMAEEAMQKKHQNTGPALEQEDKTSKVAPGTAPLPRLGATPQESSLLA 355
Query: 732 --LSKEESGMWEPLPLSSLEPAPARNPSSPERKATVPEQELQQL 773
L+ E W + AP N ++P+ + PE+ + L
Sbjct: 356 GILASELKSSWAKSGTGEVPSAPRENRTTPDCERAFPEERPEVL 399
>gi|32483399 p21-activated kinase 2 [Homo sapiens]
Length = 524
Score = 107 bits (268), Expect = 4e-23
Identities = 85/292 (29%), Positives = 136/292 (46%), Gaps = 16/292 (5%)
Query: 361 AARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDK 420
AA+ ++ K D E + EKL+ + + T ++G+G+ G V D
Sbjct: 214 AAKSLDKQKKKTKMTDEE---IMEKLRTI-VSIGDPKKKYTRYEKIGQGASGTVFTATDV 269
Query: 421 QTGFQCAVKKVRLEVFRAEEL-----MACAGLTSPRIVPLYGAVREGPWVNIFMELLEGG 475
G + A+K++ L+ +EL + L +P IV + G + + ME L GG
Sbjct: 270 ALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGG 329
Query: 476 SLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDF 535
SL +V E C+ E + + L+ LE+LH+ +++H D+K+DNVLL +GS L DF
Sbjct: 330 SLTDVVTET-CMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGS-VKLTDF 387
Query: 536 GHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHP 595
G + P+ +S + GT MAPEVV ++ KVD+WS M + M+ G P
Sbjct: 388 GFCAQITPEQSKRSTMV-----GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPP 442
Query: 596 WTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAEL 647
+ IA+ P + P +P+ + L + R SA EL
Sbjct: 443 YLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKEL 494
>gi|45827809 mitogen-activated protein kinase kinase kinase 6 [Homo
sapiens]
Length = 1288
Score = 107 bits (268), Expect = 4e-23
Identities = 118/418 (28%), Positives = 180/418 (43%), Gaps = 50/418 (11%)
Query: 346 SSGQAHSLTSLAKTWAARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLR 405
S G L + W + + + E+ EG ++ DYEY E +L
Sbjct: 605 SVGHCQWFCGLIQAWVT----NPDSTAPAEEAEGA---GEMLEFDYEYTE----TGERLV 653
Query: 406 LGRGSFGEVHRMEDKQTGFQCAVKKV-----RLEVFRAEELMACAGLTSPRIVPLYGAVR 460
LG+G++G V+ D+ T + A+K++ R EE+ L IV G+
Sbjct: 654 LGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSAS 713
Query: 461 EGPWVNIFMELLEGGSLGQLVKEQ-GCLPEDRAL--YYLGQALEGLEYLHSRRILHGDVK 517
+G ++ IFME + GGSL L++ G L ++ + +Y Q L+GL YLH I+H D+K
Sbjct: 714 QGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIK 773
Query: 518 ADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVV--LGRSCDA 575
DNVL+++ + DFG + L G + T + GT +MAPE++ R
Sbjct: 774 GDNVLINTFSGLLKISDFGTSKRL----AGITPCT-ETFTGTLQYMAPEIIDQGPRGYGK 828
Query: 576 KVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQA-IQEGL 634
D+WS C ++ M G P+ + P V PS AQA +
Sbjct: 829 AADIWSLGCTVIEMATGRPPFHE-LGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTF 887
Query: 635 RKEPIHRVSAAELGGKVNRALQQVGGLKSPWRGEYKEPRHPP-PNQA-------NYHQTL 686
+P R SA L G + LQ +SP PRH P P+ A + + T
Sbjct: 888 EPDPRLRASAQTLLG--DPFLQPGKRSRSP-----SSPRHAPRPSDAPSASPTPSANSTT 940
Query: 687 HAQ----PRELSPRAPGPRPAEETTGRAPKLQPPLPP---EPPEPNKSPPLTLSKEES 737
+Q P+ S P P + G +L+ P P EP P +S L+L +ES
Sbjct: 941 QSQTFPCPQAPSQHPPSPPKRCLSYGGTSQLRVPEEPAAEEPASPEESSGLSLLHQES 998
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 105 bits (261), Expect = 3e-22
Identities = 84/249 (33%), Positives = 121/249 (48%), Gaps = 15/249 (6%)
Query: 405 RLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE------ELMACAGLTSPRIVPLYGA 458
++G+GSFGEV + D +T A+K + LE E E+ + SP + YG+
Sbjct: 29 KIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGS 88
Query: 459 VREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKA 518
+ + I ME L GGS L+ E G L E + L + L+GL+YLHS + +H D+KA
Sbjct: 89 YLKDTKLWIIMEYLGGGSALDLL-EPGPLDETQIATILREILKGLDYLHSEKKIHRDIKA 147
Query: 519 DNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVD 578
NVLLS G L DFG A L + ++ GT MAPEV+ + D+K D
Sbjct: 148 ANVLLSEHG-EVKLADFGVAGQLTDTQIKRNTFV-----GTPFWMAPEVIKQSAYDSKAD 201
Query: 579 VWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEP 638
+WS + + G P ++ + I PP E S PL + ++ L KEP
Sbjct: 202 IWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYS-KPL-KEFVEACLNKEP 259
Query: 639 IHRVSAAEL 647
R +A EL
Sbjct: 260 SFRPTAKEL 268
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 105 bits (261), Expect = 3e-22
Identities = 84/249 (33%), Positives = 121/249 (48%), Gaps = 15/249 (6%)
Query: 405 RLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE------ELMACAGLTSPRIVPLYGA 458
++G+GSFGEV + D +T A+K + LE E E+ + SP + YG+
Sbjct: 41 KIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGS 100
Query: 459 VREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKA 518
+ + I ME L GGS L+ E G L E + L + L+GL+YLHS + +H D+KA
Sbjct: 101 YLKDTKLWIIMEYLGGGSALDLL-EPGPLDETQIATILREILKGLDYLHSEKKIHRDIKA 159
Query: 519 DNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVD 578
NVLLS G L DFG A L + ++ GT MAPEV+ + D+K D
Sbjct: 160 ANVLLSEHG-EVKLADFGVAGQLTDTQIKRNTFV-----GTPFWMAPEVIKQSAYDSKAD 213
Query: 579 VWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEP 638
+WS + + G P ++ + I PP E S PL + ++ L KEP
Sbjct: 214 IWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYS-KPL-KEFVEACLNKEP 271
Query: 639 IHRVSAAEL 647
R +A EL
Sbjct: 272 SFRPTAKEL 280
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 104 bits (259), Expect = 4e-22
Identities = 79/249 (31%), Positives = 121/249 (48%), Gaps = 14/249 (5%)
Query: 405 RLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE---ELMACAGLTSPRIVPLYGAVRE 461
+LG GS+G V + K++G A+K+V +E E E+ SP +V YG+ +
Sbjct: 32 KLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFK 91
Query: 462 GPWVNIFMELLEGGSLGQLVKEQG-CLPEDRALYYLGQALEGLEYLHSRRILHGDVKADN 520
+ I ME GS+ +++ + L ED L L+GLEYLH R +H D+KA N
Sbjct: 92 NTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGN 151
Query: 521 VLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVV--LGRSCDAKVD 578
+LL+++G HA L DFG A L ++ + + GT MAPEV+ +G +C A D
Sbjct: 152 ILLNTEG-HAKLADFGVA-----GQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVA--D 203
Query: 579 VWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEP 638
+WS + M G P+ I + PPP P + +++ L K P
Sbjct: 204 IWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNP 263
Query: 639 IHRVSAAEL 647
R +A +L
Sbjct: 264 EQRATATQL 272
>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
Length = 559
Score = 103 bits (258), Expect = 6e-22
Identities = 84/287 (29%), Positives = 136/287 (47%), Gaps = 17/287 (5%)
Query: 366 RSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQ 425
R R+ S T++ + EKL+ + + T ++G+G+ G V+ D TG +
Sbjct: 254 RQRKKSKMTDEE----ILEKLRSI-VSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQE 308
Query: 426 CAVKKVRLEVFRAEELMACAGLT-----SPRIVPLYGAVREGPWVNIFMELLEGGSLGQL 480
A+K++ L+ +EL+ L +P IV + G + + ME L GGSL +
Sbjct: 309 VAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV 368
Query: 481 VKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVC 540
V E C+ E + + L+ L++LHS +++H D+K+DN+LL DGS L DFG
Sbjct: 369 VTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS-VKLTDFGFCAQ 426
Query: 541 LQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFF 600
+ P+ +S + GT MAPEVV ++ KVD+WS M + M+ G P+
Sbjct: 427 ITPEQSKRSTMV-----GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN 481
Query: 601 RGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAEL 647
IA+ P + P + + + L + R SA EL
Sbjct: 482 PLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKEL 528
>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
Length = 565
Score = 103 bits (258), Expect = 6e-22
Identities = 84/287 (29%), Positives = 136/287 (47%), Gaps = 17/287 (5%)
Query: 366 RSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQ 425
R R+ S T++ + EKL+ + + T ++G+G+ G V+ D TG +
Sbjct: 260 RQRKKSKMTDEE----ILEKLRSI-VSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQE 314
Query: 426 CAVKKVRLEVFRAEELMACAGLT-----SPRIVPLYGAVREGPWVNIFMELLEGGSLGQL 480
A+K++ L+ +EL+ L +P IV + G + + ME L GGSL +
Sbjct: 315 VAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV 374
Query: 481 VKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVC 540
V E C+ E + + L+ L++LHS +++H D+K+DN+LL DGS L DFG
Sbjct: 375 VTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS-VKLTDFGFCAQ 432
Query: 541 LQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFF 600
+ P+ +S + GT MAPEVV ++ KVD+WS M + M+ G P+
Sbjct: 433 ITPEQSKRSTMV-----GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN 487
Query: 601 RGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAEL 647
IA+ P + P + + + L + R SA EL
Sbjct: 488 PLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKEL 534
>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
Length = 580
Score = 103 bits (258), Expect = 6e-22
Identities = 84/287 (29%), Positives = 136/287 (47%), Gaps = 17/287 (5%)
Query: 366 RSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQ 425
R R+ S T++ + EKL+ + + T ++G+G+ G V+ D TG +
Sbjct: 275 RQRKKSKMTDEE----ILEKLRSI-VSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQE 329
Query: 426 CAVKKVRLEVFRAEELMACAGLT-----SPRIVPLYGAVREGPWVNIFMELLEGGSLGQL 480
A+K++ L+ +EL+ L +P IV + G + + ME L GGSL +
Sbjct: 330 VAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV 389
Query: 481 VKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVC 540
V E C+ E + + L+ L++LHS +++H D+K+DN+LL DGS L DFG
Sbjct: 390 VTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS-VKLTDFGFCAQ 447
Query: 541 LQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFF 600
+ P+ +S + GT MAPEVV ++ KVD+WS M + M+ G P+
Sbjct: 448 ITPEQSKRSTMV-----GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN 502
Query: 601 RGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAEL 647
IA+ P + P + + + L + R SA EL
Sbjct: 503 PLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKEL 549
>gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 103 bits (258), Expect = 6e-22
Identities = 84/287 (29%), Positives = 136/287 (47%), Gaps = 17/287 (5%)
Query: 366 RSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQ 425
R R+ S T++ + EKL+ + + T ++G+G+ G V+ D TG +
Sbjct: 239 RQRKKSKMTDEE----ILEKLRSI-VSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQE 293
Query: 426 CAVKKVRLEVFRAEELMACAGLT-----SPRIVPLYGAVREGPWVNIFMELLEGGSLGQL 480
A+K++ L+ +EL+ L +P IV + G + + ME L GGSL +
Sbjct: 294 VAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV 353
Query: 481 VKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVC 540
V E C+ E + + L+ L++LHS +++H D+K+DN+LL DGS L DFG
Sbjct: 354 VTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS-VKLTDFGFCAQ 411
Query: 541 LQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFF 600
+ P+ +S + GT MAPEVV ++ KVD+WS M + M+ G P+
Sbjct: 412 ITPEQSKRSTMV-----GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN 466
Query: 601 RGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAEL 647
IA+ P + P + + + L + R SA EL
Sbjct: 467 PLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKEL 513
>gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 103 bits (258), Expect = 6e-22
Identities = 84/287 (29%), Positives = 136/287 (47%), Gaps = 17/287 (5%)
Query: 366 RSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQ 425
R R+ S T++ + EKL+ + + T ++G+G+ G V+ D TG +
Sbjct: 239 RQRKKSKMTDEE----ILEKLRSI-VSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQE 293
Query: 426 CAVKKVRLEVFRAEELMACAGLT-----SPRIVPLYGAVREGPWVNIFMELLEGGSLGQL 480
A+K++ L+ +EL+ L +P IV + G + + ME L GGSL +
Sbjct: 294 VAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV 353
Query: 481 VKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVC 540
V E C+ E + + L+ L++LHS +++H D+K+DN+LL DGS L DFG
Sbjct: 354 VTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS-VKLTDFGFCAQ 411
Query: 541 LQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFF 600
+ P+ +S + GT MAPEVV ++ KVD+WS M + M+ G P+
Sbjct: 412 ITPEQSKRSTMV-----GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN 466
Query: 601 RGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAEL 647
IA+ P + P + + + L + R SA EL
Sbjct: 467 PLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKEL 513
>gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 103 bits (258), Expect = 6e-22
Identities = 84/287 (29%), Positives = 136/287 (47%), Gaps = 17/287 (5%)
Query: 366 RSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQ 425
R R+ S T++ + EKL+ + + T ++G+G+ G V+ D TG +
Sbjct: 239 RQRKKSKMTDEE----ILEKLRSI-VSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQE 293
Query: 426 CAVKKVRLEVFRAEELMACAGLT-----SPRIVPLYGAVREGPWVNIFMELLEGGSLGQL 480
A+K++ L+ +EL+ L +P IV + G + + ME L GGSL +
Sbjct: 294 VAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV 353
Query: 481 VKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVC 540
V E C+ E + + L+ L++LHS +++H D+K+DN+LL DGS L DFG
Sbjct: 354 VTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS-VKLTDFGFCAQ 411
Query: 541 LQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFF 600
+ P+ +S + GT MAPEVV ++ KVD+WS M + M+ G P+
Sbjct: 412 ITPEQSKRSTMV-----GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN 466
Query: 601 RGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAEL 647
IA+ P + P + + + L + R SA EL
Sbjct: 467 PLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKEL 513
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 101 bits (251), Expect = 4e-21
Identities = 84/249 (33%), Positives = 117/249 (46%), Gaps = 15/249 (6%)
Query: 405 RLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE------ELMACAGLTSPRIVPLYGA 458
R+G+GSFGEV++ D T A+K + LE E E+ + SP I +G+
Sbjct: 25 RIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGS 84
Query: 459 VREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKA 518
+ + I ME L GGS L+K G L E L + L+GL+YLHS R +H D+KA
Sbjct: 85 YLKSTKLWIIMEYLGGGSALDLLKP-GPLEETYIATILREILKGLDYLHSERKIHRDIKA 143
Query: 519 DNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVD 578
NVLLS G L DFG A L + ++ GT MAPEV+ + D K D
Sbjct: 144 ANVLLSEQGD-VKLADFGVAGQLTDTQIKRNTFV-----GTPFWMAPEVIKQSAYDFKAD 197
Query: 579 VWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEP 638
+WS + + G P + + I PP E S P + ++ L K+P
Sbjct: 198 IWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHS-KPF-KEFVEACLNKDP 255
Query: 639 IHRVSAAEL 647
R +A EL
Sbjct: 256 RFRPTAKEL 264
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 99.8 bits (247), Expect = 1e-20
Identities = 111/383 (28%), Positives = 166/383 (43%), Gaps = 47/383 (12%)
Query: 406 LGRGSFGEVHRMEDKQTGFQCAVKKVRLE--------VFRAEELMACAGLTSPRIVPLYG 457
LG G+FG+V++ ++K+TG A K + + + E L C P IV L G
Sbjct: 42 LGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATC---DHPYIVKLLG 98
Query: 458 AVREGPWVNIFMELLEGGSLGQLVKE-QGCLPEDRALYYLGQALEGLEYLHSRRILHGDV 516
A + I +E GG++ ++ E L E + Q LE L +LHS+RI+H D+
Sbjct: 99 AYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDL 158
Query: 517 KADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSC--- 573
KA NVL++ +G L DFG + L K+L D GT MAPEVV+ +
Sbjct: 159 KAGNVLMTLEGD-IRLADFG----VSAKNL-KTLQKRDSFIGTPYWMAPEVVMCETMKDT 212
Query: 574 --DAKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQ 631
D K D+WS ++ M P + + LKIA PP P + ++
Sbjct: 213 PYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLK 272
Query: 632 EGLRKEPIHRVSAAEL-------GGKVNRALQQ-VGGLKSPWRGEYKEPRHPPPNQ--AN 681
L K P R SAA+L N+AL++ V K+ E ++ R + +
Sbjct: 273 IALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEGEEEDAVD 332
Query: 682 YHQTLHAQPRELSPRAP----GPRPAEE--TTGRAPKLQPPLPPEP-PEPN-------KS 727
TL + S +P +P EE +T AP EP +P+ S
Sbjct: 333 AASTLENHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTS 392
Query: 728 PPLTLSKEESGMWEPLPLSSLEP 750
PP+ E+G+ P+PL P
Sbjct: 393 PPVVAPGNENGLAVPVPLRKSRP 415
>gi|121583542 mitogen-activated protein kinase kinase kinase 15
[Homo sapiens]
Length = 788
Score = 97.8 bits (242), Expect = 4e-20
Identities = 96/341 (28%), Positives = 150/341 (43%), Gaps = 41/341 (12%)
Query: 389 VDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKV-----RLEVFRAEELMA 443
++YEY + + ++ LG+G++G V+ D + A+K++ R EE+
Sbjct: 118 LEYEYDHDANG--ERVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIAL 175
Query: 444 CAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQ-GCLPEDRALYYLGQALEG 502
L IV G+V E ++ IFME + GGSL L++ + G + E +Y Q LEG
Sbjct: 176 HKYLKHRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEG 235
Query: 503 LEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETH 562
L+YLH +I+H D+K DNVL+++ + DFG + L G + T + GT +
Sbjct: 236 LKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRL----AGVNPCT-ETFTGTLQY 290
Query: 563 MAPEVV--LGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPP 620
MAPE++ R A D+WS C ++ M P+ + + EIP
Sbjct: 291 MAPEIIDQGPRGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPE 350
Query: 621 SCAPLTAQAIQEGLRKEPIHRVSAAEL----------GGKVNR-ALQQVGG-----LKSP 664
+ + I +P R + AEL GK NR A + G L P
Sbjct: 351 ALSAEARAFILSCFEPDPHKRATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALP 410
Query: 665 WRGEYKEPRHPPPNQANYHQTL----HAQPRELSPRAPGPR 701
+GE P ++ H ++ AQP L R PR
Sbjct: 411 TQGE------PMATSSSEHGSVSPDSDAQPDALFERTRAPR 445
>gi|191252782 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 97.4 bits (241), Expect = 5e-20
Identities = 89/328 (27%), Positives = 152/328 (46%), Gaps = 27/328 (8%)
Query: 340 ALQGSVSSGQAHSLTSLA---KTWAARGSRSREPSPKTED-NEGVLLTEKLKPVDYE-YR 394
+L+ + ++GQ +S A +TW A+ S S P+ +G L E V +E ++
Sbjct: 332 SLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFK 391
Query: 395 EEVHWATHQ----------LRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELM-- 442
+ Q +++G GS G V +K +G Q AVK + L + EL+
Sbjct: 392 AALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFN 451
Query: 443 ---ACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQA 499
+V +Y + G + + ME L+GG+L +V Q L E++
Sbjct: 452 EVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVS-QVRLNEEQIATVCEAV 510
Query: 500 LEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGT 559
L+ L YLH++ ++H D+K+D++LL+ DG L DFG C Q + K + + GT
Sbjct: 511 LQALAYLHAQGVIHRDIKSDSILLTLDG-RVKLSDFG--FCAQ---ISKDVPKRKSLVGT 564
Query: 560 ETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIP 619
MAPEV+ +VD+WS M++ M++G P+ ++ PPP +
Sbjct: 565 PYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNS 624
Query: 620 PSCAPLTAQAIQEGLRKEPIHRVSAAEL 647
+P+ ++ L ++P R +A EL
Sbjct: 625 HKVSPVLRDFLERMLVRDPQERATAQEL 652
>gi|191252780 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 97.4 bits (241), Expect = 5e-20
Identities = 89/328 (27%), Positives = 152/328 (46%), Gaps = 27/328 (8%)
Query: 340 ALQGSVSSGQAHSLTSLA---KTWAARGSRSREPSPKTED-NEGVLLTEKLKPVDYE-YR 394
+L+ + ++GQ +S A +TW A+ S S P+ +G L E V +E ++
Sbjct: 332 SLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFK 391
Query: 395 EEVHWATHQ----------LRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELM-- 442
+ Q +++G GS G V +K +G Q AVK + L + EL+
Sbjct: 392 AALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFN 451
Query: 443 ---ACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQA 499
+V +Y + G + + ME L+GG+L +V Q L E++
Sbjct: 452 EVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVS-QVRLNEEQIATVCEAV 510
Query: 500 LEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGT 559
L+ L YLH++ ++H D+K+D++LL+ DG L DFG C Q + K + + GT
Sbjct: 511 LQALAYLHAQGVIHRDIKSDSILLTLDG-RVKLSDFG--FCAQ---ISKDVPKRKSLVGT 564
Query: 560 ETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIP 619
MAPEV+ +VD+WS M++ M++G P+ ++ PPP +
Sbjct: 565 PYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNS 624
Query: 620 PSCAPLTAQAIQEGLRKEPIHRVSAAEL 647
+P+ ++ L ++P R +A EL
Sbjct: 625 HKVSPVLRDFLERMLVRDPQERATAQEL 652
>gi|9910476 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 97.4 bits (241), Expect = 5e-20
Identities = 89/328 (27%), Positives = 152/328 (46%), Gaps = 27/328 (8%)
Query: 340 ALQGSVSSGQAHSLTSLA---KTWAARGSRSREPSPKTED-NEGVLLTEKLKPVDYE-YR 394
+L+ + ++GQ +S A +TW A+ S S P+ +G L E V +E ++
Sbjct: 332 SLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFK 391
Query: 395 EEVHWATHQ----------LRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELM-- 442
+ Q +++G GS G V +K +G Q AVK + L + EL+
Sbjct: 392 AALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFN 451
Query: 443 ---ACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQA 499
+V +Y + G + + ME L+GG+L +V Q L E++
Sbjct: 452 EVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVS-QVRLNEEQIATVCEAV 510
Query: 500 LEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGT 559
L+ L YLH++ ++H D+K+D++LL+ DG L DFG C Q + K + + GT
Sbjct: 511 LQALAYLHAQGVIHRDIKSDSILLTLDG-RVKLSDFG--FCAQ---ISKDVPKRKSLVGT 564
Query: 560 ETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIP 619
MAPEV+ +VD+WS M++ M++G P+ ++ PPP +
Sbjct: 565 PYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNS 624
Query: 620 PSCAPLTAQAIQEGLRKEPIHRVSAAEL 647
+P+ ++ L ++P R +A EL
Sbjct: 625 HKVSPVLRDFLERMLVRDPQERATAQEL 652
>gi|21359873 polo-like kinase 1 [Homo sapiens]
Length = 603
Score = 97.1 bits (240), Expect = 7e-20
Identities = 104/376 (27%), Positives = 158/376 (42%), Gaps = 43/376 (11%)
Query: 406 LGRGSFGEVHRMEDKQT----GFQCAVKKVRLEVFRAE----ELMACAGLTSPRIVPLYG 457
LG+G F + + D T + K + L+ + E E+ L +V +G
Sbjct: 59 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 118
Query: 458 AVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVK 517
+ +V + +EL SL +L K + L E A YYL Q + G +YLH R++H D+K
Sbjct: 119 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 178
Query: 518 ADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKV 577
N+ L+ D + DFG A ++ DG K L GT ++APEV+ + +V
Sbjct: 179 LGNLFLNED-LEVKIGDFGLATKVEYDGERKKTLC-----GTPNYIAPEVLSKKGHSFEV 232
Query: 578 DVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKE 637
DVWS C+M +L G P+ L+I IP P+ A IQ+ L+ +
Sbjct: 233 DVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNE---YSIPKHINPVAASLIQKMLQTD 289
Query: 638 PIHRVSAAELGGKVNRALQQVGGLKSPWRGEYKEPRHPPPNQANYHQTLHAQPR-ELSPR 696
P R + EL +N G Y R P L PR ++P
Sbjct: 290 PTARPTINEL---LNDEFFTSG---------YIPARLP-------ITCLTIPPRFSIAPS 330
Query: 697 APGPRPAEETTGRAPKLQPPLPPEPPEPNKSPPLTLSKEESGMWEPLPLSS-LEPAPARN 755
+ P + T L+ PLP P E K P+ E+G LS L+ + N
Sbjct: 331 SLDPSNRKPLTVLNKGLENPLPERPRE--KEEPVV---RETGEVVDCHLSDMLQQLHSVN 385
Query: 756 PSSPERKATVPEQELQ 771
S P + V ++E +
Sbjct: 386 ASKPSERGLVRQEEAE 401
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 97.1 bits (240), Expect = 7e-20
Identities = 79/249 (31%), Positives = 115/249 (46%), Gaps = 15/249 (6%)
Query: 405 RLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE------ELMACAGLTSPRIVPLYGA 458
R+G+GSFGEV + D +T A+K + LE E E+ + S + YG+
Sbjct: 29 RIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGS 88
Query: 459 VREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKA 518
+G + I ME L GGS L++ G E + L + L+GL+YLHS + +H D+KA
Sbjct: 89 YLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKA 147
Query: 519 DNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVD 578
NVLLS G L DFG A L + ++ GT MAPEV+ + D+K D
Sbjct: 148 ANVLLSEQGD-VKLADFGVAGQLTDTQIKRNTFV-----GTPFWMAPEVIQQSAYDSKAD 201
Query: 579 VWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEP 638
+WS + + G P + + I PP + + I L K+P
Sbjct: 202 IWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPT--LVGDFTKSFKEFIDACLNKDP 259
Query: 639 IHRVSAAEL 647
R +A EL
Sbjct: 260 SFRPTAKEL 268
>gi|29826329 p21-activated kinase 7 [Homo sapiens]
Length = 719
Score = 96.7 bits (239), Expect = 9e-20
Identities = 92/314 (29%), Positives = 144/314 (45%), Gaps = 27/314 (8%)
Query: 345 VSSGQAHSLTSLAKTWAARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQL 404
+SS S T +W + S ++PS + + L + P D + + +
Sbjct: 401 LSSLSLSSSTYPPPSWGS--SSDQQPSRVSHEQFRAALQLVVSPGDPR-----EYLANFI 453
Query: 405 RLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELM-----ACAGLTSPRIVPLYGAV 459
++G GS G V +K TG Q AVKK+ L + EL+ +V +Y +
Sbjct: 454 KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSY 513
Query: 460 REGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKAD 519
G + + ME LEGG+L +V E A L L L YLH++ ++H D+K+D
Sbjct: 514 LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLS-VLRALSYLHNQGVIHRDIKSD 572
Query: 520 NVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDV 579
++LL+SDG L DFG C Q + K + + GT MAPEV+ +VD+
Sbjct: 573 SILLTSDG-RIKLSDFG--FCAQ---VSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDI 626
Query: 580 WSSCCMMLHMLNGCHPWTQFFRGPLCLKIA----SEPPPVREIPPSCAPLTAQAIQEGLR 635
WS M++ M++G P +F P + S PP V+++ + L + L
Sbjct: 627 WSLGIMVIEMIDGEPP---YFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRG-FLDLMLV 682
Query: 636 KEPIHRVSAAELGG 649
+EP R +A EL G
Sbjct: 683 REPSQRATAQELLG 696
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.132 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,644,858
Number of Sequences: 37866
Number of extensions: 2715376
Number of successful extensions: 18680
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 690
Number of HSP's successfully gapped in prelim test: 891
Number of HSP's that attempted gapping in prelim test: 11682
Number of HSP's gapped (non-prelim): 5046
length of query: 947
length of database: 18,247,518
effective HSP length: 112
effective length of query: 835
effective length of database: 14,006,526
effective search space: 11695449210
effective search space used: 11695449210
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.