Search of human proteins with 114155135

Search of human proteins with 114155135

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|114155135 dynein, axonemal, heavy chain 9 isoform 1 [Homo
sapiens]
         (798 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|114155135 dynein, axonemal, heavy chain 9 isoform 1 [Homo sap...  1624   0.0  
gi|114155133 dynein, axonemal, heavy chain 9 isoform 2 [Homo sap...  1624   0.0  
gi|239756957 PREDICTED: dynein, axonemal, heavy chain 17 [Homo s...  1236   0.0  
gi|239751459 PREDICTED: dynein, axonemal, heavy chain 17 [Homo s...  1213   0.0  
gi|239745966 PREDICTED: dynein, axonemal, heavy chain 17 [Homo s...  1213   0.0  
gi|51479173 dynein, axonemal, heavy chain 11 [Homo sapiens]          1094   0.0  
gi|75677365 dynein heavy chain domain 3 [Homo sapiens]                486   e-137
gi|24308169 dynein, axonemal, heavy chain 3 [Homo sapiens]            484   e-136
gi|197927452 dynein, axonemal, heavy chain 1 [Homo sapiens]           481   e-135
gi|151301127 dynein, axonemal, heavy chain 7 [Homo sapiens]           478   e-135
gi|198442844 dynein, axonemal, heavy chain 10 [Homo sapiens]          478   e-134
gi|19115954 dynein, axonemal, heavy chain 5 [Homo sapiens]            445   e-125
gi|126012497 dynein, axonemal, heavy polypeptide 8 [Homo sapiens]     444   e-124
gi|194440727 dynein heavy chain domain 2 isoform 1 [Homo sapiens]     435   e-122
gi|194353966 dynein, axonemal, heavy polypeptide 6 [Homo sapiens]     400   e-111
gi|223555935 dynein, axonemal, heavy polypeptide 14 isoform 1 [H...   292   7e-79
gi|122937398 dynein, cytoplasmic 2, heavy chain 1 [Homo sapiens]      235   1e-61
gi|33350932 cytoplasmic dynein 1 heavy chain 1 [Homo sapiens]         229   8e-60
gi|222144249 dynein heavy chain domain 1 isoform 1 [Homo sapiens]      87   6e-17
gi|24415404 MDN1, midasin homolog [Homo sapiens]                       37   0.055
gi|110618244 retinoblastoma binding protein 2 isoform 1 [Homo sa...    34   0.47 
gi|110618242 retinoblastoma binding protein 2 isoform 2 [Homo sa...    34   0.47 
gi|119703749 hydrocephalus inducing isoform a [Homo sapiens]           34   0.61 
gi|167860120 phospholipase A2, group IVB [Homo sapiens]                33   1.4  
gi|4826914 JMJD7-PLA2G4B protein [Homo sapiens]                        33   1.4  
gi|118918407 spectrin repeat containing, nuclear envelope 2 isof...    32   1.8  
gi|118918403 spectrin repeat containing, nuclear envelope 2 isof...    32   1.8  
gi|4758528 hepatocyte growth factor-regulated tyrosine kinase su...    32   2.3  
gi|205277396 dynactin 1 isoform 4 [Homo sapiens]                       32   3.0  
gi|205277392 dynactin 1 isoform 3 [Homo sapiens]                       32   3.0  

>gi|114155135 dynein, axonemal, heavy chain 9 isoform 1 [Homo
           sapiens]
          Length = 798

 Score = 1624 bits (4205), Expect = 0.0
 Identities = 798/798 (100%), Positives = 798/798 (100%)

Query: 1   MNDLSKIHPMYQFSLKAFSIVFQKAVERAAPDESLRERVANLIDSITFSVYQYTIRGLFE 60
           MNDLSKIHPMYQFSLKAFSIVFQKAVERAAPDESLRERVANLIDSITFSVYQYTIRGLFE
Sbjct: 1   MNDLSKIHPMYQFSLKAFSIVFQKAVERAAPDESLRERVANLIDSITFSVYQYTIRGLFE 60

Query: 61  CDKLTYLAQLTFQILLMNREVNAVELDFLLRSPVQTGTASPVEFLSHQAWGAVKVLSSME 120
           CDKLTYLAQLTFQILLMNREVNAVELDFLLRSPVQTGTASPVEFLSHQAWGAVKVLSSME
Sbjct: 61  CDKLTYLAQLTFQILLMNREVNAVELDFLLRSPVQTGTASPVEFLSHQAWGAVKVLSSME 120

Query: 121 EFSNLDRDIEGSAKSWKKFVESECPEKEKLPQEWKNKTALQRLCMLRAMRPDRMTYALRD 180
           EFSNLDRDIEGSAKSWKKFVESECPEKEKLPQEWKNKTALQRLCMLRAMRPDRMTYALRD
Sbjct: 121 EFSNLDRDIEGSAKSWKKFVESECPEKEKLPQEWKNKTALQRLCMLRAMRPDRMTYALRD 180

Query: 181 FVEEKLGSKYVVGRALDFATSFEESGPATPMFFILSPGVDPLKDVESQGRKLGYTFNNQN 240
           FVEEKLGSKYVVGRALDFATSFEESGPATPMFFILSPGVDPLKDVESQGRKLGYTFNNQN
Sbjct: 181 FVEEKLGSKYVVGRALDFATSFEESGPATPMFFILSPGVDPLKDVESQGRKLGYTFNNQN 240

Query: 241 FHNVSLGQGQEVVAEAALDLAAKKGHWVILQNIHLVAKWLSTLEKKLEEHSENSHPEFRV 300
           FHNVSLGQGQEVVAEAALDLAAKKGHWVILQNIHLVAKWLSTLEKKLEEHSENSHPEFRV
Sbjct: 241 FHNVSLGQGQEVVAEAALDLAAKKGHWVILQNIHLVAKWLSTLEKKLEEHSENSHPEFRV 300

Query: 301 FMSAEPAPSPEGHIIPQGILENSIKITNEPPTGMHANLHKALDNFTQDTLEMCSRETEFK 360
           FMSAEPAPSPEGHIIPQGILENSIKITNEPPTGMHANLHKALDNFTQDTLEMCSRETEFK
Sbjct: 301 FMSAEPAPSPEGHIIPQGILENSIKITNEPPTGMHANLHKALDNFTQDTLEMCSRETEFK 360

Query: 361 SILFALCYFHAVVAERRKFGPQGWNRSYPFNTGDLTISVNVLYNFLEANAKVPYDDLRYL 420
           SILFALCYFHAVVAERRKFGPQGWNRSYPFNTGDLTISVNVLYNFLEANAKVPYDDLRYL
Sbjct: 361 SILFALCYFHAVVAERRKFGPQGWNRSYPFNTGDLTISVNVLYNFLEANAKVPYDDLRYL 420

Query: 421 FGEIMYGGHITDDWDRRLCRTYLGEFIRPEMLEGELSLAPGFPLPGNMDYNGYHQYIDAE 480
           FGEIMYGGHITDDWDRRLCRTYLGEFIRPEMLEGELSLAPGFPLPGNMDYNGYHQYIDAE
Sbjct: 421 FGEIMYGGHITDDWDRRLCRTYLGEFIRPEMLEGELSLAPGFPLPGNMDYNGYHQYIDAE 480

Query: 481 LPPESPYLYGLHPNAEIGFLTQTSEKLFRTVLELQPRDSQARDGAGATREEKVKALLEEI 540
           LPPESPYLYGLHPNAEIGFLTQTSEKLFRTVLELQPRDSQARDGAGATREEKVKALLEEI
Sbjct: 481 LPPESPYLYGLHPNAEIGFLTQTSEKLFRTVLELQPRDSQARDGAGATREEKVKALLEEI 540

Query: 541 LERVTDEFNIPELMAKVEERTPYIVVAFQECGRMNILTREIQRSLRELELGLKGELTMTS 600
           LERVTDEFNIPELMAKVEERTPYIVVAFQECGRMNILTREIQRSLRELELGLKGELTMTS
Sbjct: 541 LERVTDEFNIPELMAKVEERTPYIVVAFQECGRMNILTREIQRSLRELELGLKGELTMTS 600

Query: 601 HMENLQNALYFDMVPESWARRAYPSTAGLAAWFPDLLNRIKELEAWTGDFTMPSTVWLTG 660
           HMENLQNALYFDMVPESWARRAYPSTAGLAAWFPDLLNRIKELEAWTGDFTMPSTVWLTG
Sbjct: 601 HMENLQNALYFDMVPESWARRAYPSTAGLAAWFPDLLNRIKELEAWTGDFTMPSTVWLTG 660

Query: 661 FFNPQSFLTAIMQSTARKNEWPLDQMALQCDMTKKNREEFRSPPREGAYIHGLFMEGACW 720
           FFNPQSFLTAIMQSTARKNEWPLDQMALQCDMTKKNREEFRSPPREGAYIHGLFMEGACW
Sbjct: 661 FFNPQSFLTAIMQSTARKNEWPLDQMALQCDMTKKNREEFRSPPREGAYIHGLFMEGACW 720

Query: 721 DTQAGIITEAKLKDLTPPMPVMFIKAIPADKQDCRSVYSCPVYKTSQRGPTYVWTFNLKT 780
           DTQAGIITEAKLKDLTPPMPVMFIKAIPADKQDCRSVYSCPVYKTSQRGPTYVWTFNLKT
Sbjct: 721 DTQAGIITEAKLKDLTPPMPVMFIKAIPADKQDCRSVYSCPVYKTSQRGPTYVWTFNLKT 780

Query: 781 KENPSKWVLAGVALLLQI 798
           KENPSKWVLAGVALLLQI
Sbjct: 781 KENPSKWVLAGVALLLQI 798


>gi|114155133 dynein, axonemal, heavy chain 9 isoform 2 [Homo sapiens]
          Length = 4486

 Score = 1624 bits (4205), Expect = 0.0
 Identities = 798/798 (100%), Positives = 798/798 (100%)

Query: 1    MNDLSKIHPMYQFSLKAFSIVFQKAVERAAPDESLRERVANLIDSITFSVYQYTIRGLFE 60
            MNDLSKIHPMYQFSLKAFSIVFQKAVERAAPDESLRERVANLIDSITFSVYQYTIRGLFE
Sbjct: 3689 MNDLSKIHPMYQFSLKAFSIVFQKAVERAAPDESLRERVANLIDSITFSVYQYTIRGLFE 3748

Query: 61   CDKLTYLAQLTFQILLMNREVNAVELDFLLRSPVQTGTASPVEFLSHQAWGAVKVLSSME 120
            CDKLTYLAQLTFQILLMNREVNAVELDFLLRSPVQTGTASPVEFLSHQAWGAVKVLSSME
Sbjct: 3749 CDKLTYLAQLTFQILLMNREVNAVELDFLLRSPVQTGTASPVEFLSHQAWGAVKVLSSME 3808

Query: 121  EFSNLDRDIEGSAKSWKKFVESECPEKEKLPQEWKNKTALQRLCMLRAMRPDRMTYALRD 180
            EFSNLDRDIEGSAKSWKKFVESECPEKEKLPQEWKNKTALQRLCMLRAMRPDRMTYALRD
Sbjct: 3809 EFSNLDRDIEGSAKSWKKFVESECPEKEKLPQEWKNKTALQRLCMLRAMRPDRMTYALRD 3868

Query: 181  FVEEKLGSKYVVGRALDFATSFEESGPATPMFFILSPGVDPLKDVESQGRKLGYTFNNQN 240
            FVEEKLGSKYVVGRALDFATSFEESGPATPMFFILSPGVDPLKDVESQGRKLGYTFNNQN
Sbjct: 3869 FVEEKLGSKYVVGRALDFATSFEESGPATPMFFILSPGVDPLKDVESQGRKLGYTFNNQN 3928

Query: 241  FHNVSLGQGQEVVAEAALDLAAKKGHWVILQNIHLVAKWLSTLEKKLEEHSENSHPEFRV 300
            FHNVSLGQGQEVVAEAALDLAAKKGHWVILQNIHLVAKWLSTLEKKLEEHSENSHPEFRV
Sbjct: 3929 FHNVSLGQGQEVVAEAALDLAAKKGHWVILQNIHLVAKWLSTLEKKLEEHSENSHPEFRV 3988

Query: 301  FMSAEPAPSPEGHIIPQGILENSIKITNEPPTGMHANLHKALDNFTQDTLEMCSRETEFK 360
            FMSAEPAPSPEGHIIPQGILENSIKITNEPPTGMHANLHKALDNFTQDTLEMCSRETEFK
Sbjct: 3989 FMSAEPAPSPEGHIIPQGILENSIKITNEPPTGMHANLHKALDNFTQDTLEMCSRETEFK 4048

Query: 361  SILFALCYFHAVVAERRKFGPQGWNRSYPFNTGDLTISVNVLYNFLEANAKVPYDDLRYL 420
            SILFALCYFHAVVAERRKFGPQGWNRSYPFNTGDLTISVNVLYNFLEANAKVPYDDLRYL
Sbjct: 4049 SILFALCYFHAVVAERRKFGPQGWNRSYPFNTGDLTISVNVLYNFLEANAKVPYDDLRYL 4108

Query: 421  FGEIMYGGHITDDWDRRLCRTYLGEFIRPEMLEGELSLAPGFPLPGNMDYNGYHQYIDAE 480
            FGEIMYGGHITDDWDRRLCRTYLGEFIRPEMLEGELSLAPGFPLPGNMDYNGYHQYIDAE
Sbjct: 4109 FGEIMYGGHITDDWDRRLCRTYLGEFIRPEMLEGELSLAPGFPLPGNMDYNGYHQYIDAE 4168

Query: 481  LPPESPYLYGLHPNAEIGFLTQTSEKLFRTVLELQPRDSQARDGAGATREEKVKALLEEI 540
            LPPESPYLYGLHPNAEIGFLTQTSEKLFRTVLELQPRDSQARDGAGATREEKVKALLEEI
Sbjct: 4169 LPPESPYLYGLHPNAEIGFLTQTSEKLFRTVLELQPRDSQARDGAGATREEKVKALLEEI 4228

Query: 541  LERVTDEFNIPELMAKVEERTPYIVVAFQECGRMNILTREIQRSLRELELGLKGELTMTS 600
            LERVTDEFNIPELMAKVEERTPYIVVAFQECGRMNILTREIQRSLRELELGLKGELTMTS
Sbjct: 4229 LERVTDEFNIPELMAKVEERTPYIVVAFQECGRMNILTREIQRSLRELELGLKGELTMTS 4288

Query: 601  HMENLQNALYFDMVPESWARRAYPSTAGLAAWFPDLLNRIKELEAWTGDFTMPSTVWLTG 660
            HMENLQNALYFDMVPESWARRAYPSTAGLAAWFPDLLNRIKELEAWTGDFTMPSTVWLTG
Sbjct: 4289 HMENLQNALYFDMVPESWARRAYPSTAGLAAWFPDLLNRIKELEAWTGDFTMPSTVWLTG 4348

Query: 661  FFNPQSFLTAIMQSTARKNEWPLDQMALQCDMTKKNREEFRSPPREGAYIHGLFMEGACW 720
            FFNPQSFLTAIMQSTARKNEWPLDQMALQCDMTKKNREEFRSPPREGAYIHGLFMEGACW
Sbjct: 4349 FFNPQSFLTAIMQSTARKNEWPLDQMALQCDMTKKNREEFRSPPREGAYIHGLFMEGACW 4408

Query: 721  DTQAGIITEAKLKDLTPPMPVMFIKAIPADKQDCRSVYSCPVYKTSQRGPTYVWTFNLKT 780
            DTQAGIITEAKLKDLTPPMPVMFIKAIPADKQDCRSVYSCPVYKTSQRGPTYVWTFNLKT
Sbjct: 4409 DTQAGIITEAKLKDLTPPMPVMFIKAIPADKQDCRSVYSCPVYKTSQRGPTYVWTFNLKT 4468

Query: 781  KENPSKWVLAGVALLLQI 798
            KENPSKWVLAGVALLLQI
Sbjct: 4469 KENPSKWVLAGVALLLQI 4486


>gi|239756957 PREDICTED: dynein, axonemal, heavy chain 17 [Homo
            sapiens]
          Length = 4470

 Score = 1236 bits (3198), Expect = 0.0
 Identities = 575/798 (72%), Positives = 689/798 (86%)

Query: 1    MNDLSKIHPMYQFSLKAFSIVFQKAVERAAPDESLRERVANLIDSITFSVYQYTIRGLFE 60
            +NDL+KI+P+YQFSLKAF++VF+KA++R  P   +++RV NL D IT+SVY YT RGLFE
Sbjct: 3673 LNDLNKINPVYQFSLKAFNVVFEKAIQRTTPANEVKQRVINLTDEITYSVYMYTARGLFE 3732

Query: 61   CDKLTYLAQLTFQILLMNREVNAVELDFLLRSPVQTGTASPVEFLSHQAWGAVKVLSSME 120
             DKL +LAQ+TFQ+L M +E+N VELDFLLR P + G  SPV+FL HQ WG +K LS M+
Sbjct: 3733 RDKLIFLAQVTFQVLSMKKELNPVELDFLLRFPFKAGVVSPVDFLQHQGWGGIKALSEMD 3792

Query: 121  EFSNLDRDIEGSAKSWKKFVESECPEKEKLPQEWKNKTALQRLCMLRAMRPDRMTYALRD 180
            EF NLD DIEGSAK WKK VESE PEKE  P+EWKNKTALQ+LCM+R +RPDRMTYA+++
Sbjct: 3793 EFKNLDSDIEGSAKRWKKLVESEAPEKEIFPKEWKNKTALQKLCMVRCLRPDRMTYAIKN 3852

Query: 181  FVEEKLGSKYVVGRALDFATSFEESGPATPMFFILSPGVDPLKDVESQGRKLGYTFNNQN 240
            FVEEK+GSK+V GR+++F+ S+EES P+T +FFILSPGVDPLKDVE+ G+KLG+T +N  
Sbjct: 3853 FVEEKMGSKFVEGRSVEFSKSYEESSPSTSIFFILSPGVDPLKDVEALGKKLGFTIDNGK 3912

Query: 241  FHNVSLGQGQEVVAEAALDLAAKKGHWVILQNIHLVAKWLSTLEKKLEEHSENSHPEFRV 300
             HNVSLGQGQEVVAE ALD+AA+KGHWVILQNIHLVA+WL TL+KKLE +S  SH ++RV
Sbjct: 3913 LHNVSLGQGQEVVAENALDVAAEKGHWVILQNIHLVARWLGTLDKKLERYSTGSHEDYRV 3972

Query: 301  FMSAEPAPSPEGHIIPQGILENSIKITNEPPTGMHANLHKALDNFTQDTLEMCSRETEFK 360
            F+SAEPAPSPE HIIPQGILEN+IKITNEPPTGMHANLHKALD FTQDTLEMC++E EFK
Sbjct: 3973 FISAEPAPSPETHIIPQGILENAIKITNEPPTGMHANLHKALDLFTQDTLEMCTKEMEFK 4032

Query: 361  SILFALCYFHAVVAERRKFGPQGWNRSYPFNTGDLTISVNVLYNFLEANAKVPYDDLRYL 420
             +LFALCYFHAVVAERRKFG QGWNRSYPFN GDLTIS+NVLYN+LEAN KVP+DDLRYL
Sbjct: 4033 CMLFALCYFHAVVAERRKFGAQGWNRSYPFNNGDLTISINVLYNYLEANPKVPWDDLRYL 4092

Query: 421  FGEIMYGGHITDDWDRRLCRTYLGEFIRPEMLEGELSLAPGFPLPGNMDYNGYHQYIDAE 480
            FGEIMYGGHITDDWDRRLCRTYL E+IR EMLEG++ LAPGF +P N+DY GYH+YID  
Sbjct: 4093 FGEIMYGGHITDDWDRRLCRTYLAEYIRTEMLEGDVLLAPGFQIPPNLDYKGYHEYIDEN 4152

Query: 481  LPPESPYLYGLHPNAEIGFLTQTSEKLFRTVLELQPRDSQARDGAGATREEKVKALLEEI 540
            LPPESPYLYGLHPNAEIGFLT TSEKLFRTVLE+QP+++ +  G G +REEKVKA+L++I
Sbjct: 4153 LPPESPYLYGLHPNAEIGFLTVTSEKLFRTVLEMQPKETDSGAGTGVSREEKVKAVLDDI 4212

Query: 541  LERVTDEFNIPELMAKVEERTPYIVVAFQECGRMNILTREIQRSLRELELGLKGELTMTS 600
            LE++ + FN+ E+MAK  E+TPY+VVAFQEC RMNILT E++RSL+EL LGLKGELT+T+
Sbjct: 4213 LEKIPETFNMAEIMAKAAEKTPYVVVAFQECERMNILTNEMRRSLKELNLGLKGELTITT 4272

Query: 601  HMENLQNALYFDMVPESWARRAYPSTAGLAAWFPDLLNRIKELEAWTGDFTMPSTVWLTG 660
             +E+L  AL++D VP++W  RAYPS  GLAAW+ DLL RI+ELEAWT DF +P+TVWL G
Sbjct: 4273 DVEDLSTALFYDTVPDTWVARAYPSMMGLAAWYADLLLRIRELEAWTTDFALPTTVWLAG 4332

Query: 661  FFNPQSFLTAIMQSTARKNEWPLDQMALQCDMTKKNREEFRSPPREGAYIHGLFMEGACW 720
            FFNPQSFLTAIMQS ARKNEWPLD+M L  ++TKKNRE+  +PPREG+Y++GLFMEGA W
Sbjct: 4333 FFNPQSFLTAIMQSMARKNEWPLDKMCLSVEVTKKNREDMTAPPREGSYVYGLFMEGARW 4392

Query: 721  DTQAGIITEAKLKDLTPPMPVMFIKAIPADKQDCRSVYSCPVYKTSQRGPTYVWTFNLKT 780
            DTQ G+I EA+LK+LTP MPV+FIKAIP D+ + +++Y CPVYKT  RGPTYVWTFNLKT
Sbjct: 4393 DTQTGVIAEARLKELTPAMPVIFIKAIPVDRMETKNIYECPVYKTRIRGPTYVWTFNLKT 4452

Query: 781  KENPSKWVLAGVALLLQI 798
            KE  +KW+LA VALLLQ+
Sbjct: 4453 KEKAAKWILAAVALLLQV 4470


>gi|239751459 PREDICTED: dynein, axonemal, heavy chain 17 [Homo
            sapiens]
          Length = 4485

 Score = 1213 bits (3139), Expect = 0.0
 Identities = 575/835 (68%), Positives = 689/835 (82%), Gaps = 37/835 (4%)

Query: 1    MNDLSKIHPMYQFSLKAFSIVFQKAVERAAPDESLRERVANLIDSITFSVYQYTIRGLFE 60
            +NDL+KI+P+YQFSLKAF++VF+KA++R  P   +++RV NL D IT+SVY YT RGLFE
Sbjct: 3651 LNDLNKINPVYQFSLKAFNVVFEKAIQRTTPANEVKQRVINLTDEITYSVYMYTARGLFE 3710

Query: 61   CDKLTYLAQLTFQILLMNREVNAVELDFLLRSPVQTGTASPVEFLSHQAWGAVKVLSSME 120
             DKL +LAQ+TFQ+L M +E+N VELDFLLR P + G  SPV+FL HQ WG +K LS M+
Sbjct: 3711 RDKLIFLAQVTFQVLSMKKELNPVELDFLLRFPFKAGVVSPVDFLQHQGWGGIKALSEMD 3770

Query: 121  EFSNLDRDIEGSAKSWKKFVESECPEKEKLPQEWKNKTALQRLCMLRAMRPDRMTYALRD 180
            EF NLD DIEGSAK WKK VESE PEKE  P+EWKNKTALQ+LCM+R +RPDRMTYA+++
Sbjct: 3771 EFKNLDSDIEGSAKRWKKLVESEAPEKEIFPKEWKNKTALQKLCMVRCLRPDRMTYAIKN 3830

Query: 181  FVEEKLGSKYVVGRALDFATSFEESGPATPMFFILSPGVDPLKDVESQGRKLGYTFNNQN 240
            FVEEK+GSK+V GR+++F+ S+EES P+T +FFILSPGVDPLKDVE+ G+KLG+T +N  
Sbjct: 3831 FVEEKMGSKFVEGRSVEFSKSYEESSPSTSIFFILSPGVDPLKDVEALGKKLGFTIDNGK 3890

Query: 241  FHNVSLGQGQEVVAEAALDLAAKKGHWVILQ--------NIHLVAKWLSTLEKKLEEHSE 292
             HNVSLGQGQEVVAE ALD+AA+KGHWVILQ        NIHLVA+WL TL+KKLE +S 
Sbjct: 3891 LHNVSLGQGQEVVAENALDVAAEKGHWVILQVRGGQHCRNIHLVARWLGTLDKKLERYST 3950

Query: 293  NSHPEFRVFMSAEPAPSPEGHIIPQGILENSIKITNEPPTGMHANLHKALDNFTQDTLEM 352
             SH ++RVF+SAEPAPSPE HIIPQGILEN+IKITNEPPTGMHANLHKALD FTQDTLEM
Sbjct: 3951 GSHEDYRVFISAEPAPSPETHIIPQGILENAIKITNEPPTGMHANLHKALDLFTQDTLEM 4010

Query: 353  CSRETEFKSILFALCYFHAVVAERRKFGPQGWNRSYPFNTGDLTISVNVLYNFLEANAKV 412
            C++E EFK +LFALCYFHAVVAERRKFG QGWNRSYPFN GDLTIS+NVLYN+LEAN KV
Sbjct: 4011 CTKEMEFKCMLFALCYFHAVVAERRKFGAQGWNRSYPFNNGDLTISINVLYNYLEANPKV 4070

Query: 413  PYDDLRYLFGEIMYGGHITDDWDRRLCRTYLGEFIRPEMLEGELSLAPGFPLPGNMDYNG 472
            P+DDLRYLFGEIMYGGHITDDWDRRLCRTYL E+IR EMLEG++ LAPGF +P N+DY G
Sbjct: 4071 PWDDLRYLFGEIMYGGHITDDWDRRLCRTYLAEYIRTEMLEGDVLLAPGFQIPPNLDYKG 4130

Query: 473  YHQYIDAELPPESPYLYGLHPNAEIGFLTQTSEKLFRTVLELQPRDSQARDGAGATREEK 532
            YH+YID  LPPESPYLYGLHPNAEIGFLT TSEKLFRTVLE+QP+++ +  G G +REEK
Sbjct: 4131 YHEYIDENLPPESPYLYGLHPNAEIGFLTVTSEKLFRTVLEMQPKETDSGAGTGVSREEK 4190

Query: 533  -----------------------------VKALLEEILERVTDEFNIPELMAKVEERTPY 563
                                         VKA+L++ILE++ + FN+ E+MAK  E+TPY
Sbjct: 4191 AGSLKLLPSERKGEDLELRRGGCPGTGFQVKAVLDDILEKIPETFNMAEIMAKAAEKTPY 4250

Query: 564  IVVAFQECGRMNILTREIQRSLRELELGLKGELTMTSHMENLQNALYFDMVPESWARRAY 623
            +VVAFQEC RMNILT E++RSL+EL LGLKGELT+T+ +E+L  AL++D VP++W  RAY
Sbjct: 4251 VVVAFQECERMNILTNEMRRSLKELNLGLKGELTITTDVEDLSTALFYDTVPDTWVARAY 4310

Query: 624  PSTAGLAAWFPDLLNRIKELEAWTGDFTMPSTVWLTGFFNPQSFLTAIMQSTARKNEWPL 683
            PS  GLAAW+ DLL RI+ELEAWT DF +P+TVWL GFFNPQSFLTAIMQS ARKNEWPL
Sbjct: 4311 PSMMGLAAWYADLLLRIRELEAWTTDFALPTTVWLAGFFNPQSFLTAIMQSMARKNEWPL 4370

Query: 684  DQMALQCDMTKKNREEFRSPPREGAYIHGLFMEGACWDTQAGIITEAKLKDLTPPMPVMF 743
            D+M L  ++TKKNRE+  +PPREG+Y++GLFMEGA WDTQ G+I EA+LK+LTP MPV+F
Sbjct: 4371 DKMCLSVEVTKKNREDMTAPPREGSYVYGLFMEGARWDTQTGVIAEARLKELTPAMPVIF 4430

Query: 744  IKAIPADKQDCRSVYSCPVYKTSQRGPTYVWTFNLKTKENPSKWVLAGVALLLQI 798
            IKAIP D+ + +++Y CPVYKT  RGPTYVWTFNLKTKE  +KW+LA VALLLQ+
Sbjct: 4431 IKAIPVDRMETKNIYECPVYKTRIRGPTYVWTFNLKTKEKAAKWILAAVALLLQV 4485


>gi|239745966 PREDICTED: dynein, axonemal, heavy chain 17 [Homo
            sapiens]
          Length = 4485

 Score = 1213 bits (3139), Expect = 0.0
 Identities = 575/835 (68%), Positives = 689/835 (82%), Gaps = 37/835 (4%)

Query: 1    MNDLSKIHPMYQFSLKAFSIVFQKAVERAAPDESLRERVANLIDSITFSVYQYTIRGLFE 60
            +NDL+KI+P+YQFSLKAF++VF+KA++R  P   +++RV NL D IT+SVY YT RGLFE
Sbjct: 3651 LNDLNKINPVYQFSLKAFNVVFEKAIQRTTPANEVKQRVINLTDEITYSVYMYTARGLFE 3710

Query: 61   CDKLTYLAQLTFQILLMNREVNAVELDFLLRSPVQTGTASPVEFLSHQAWGAVKVLSSME 120
             DKL +LAQ+TFQ+L M +E+N VELDFLLR P + G  SPV+FL HQ WG +K LS M+
Sbjct: 3711 RDKLIFLAQVTFQVLSMKKELNPVELDFLLRFPFKAGVVSPVDFLQHQGWGGIKALSEMD 3770

Query: 121  EFSNLDRDIEGSAKSWKKFVESECPEKEKLPQEWKNKTALQRLCMLRAMRPDRMTYALRD 180
            EF NLD DIEGSAK WKK VESE PEKE  P+EWKNKTALQ+LCM+R +RPDRMTYA+++
Sbjct: 3771 EFKNLDSDIEGSAKRWKKLVESEAPEKEIFPKEWKNKTALQKLCMVRCLRPDRMTYAIKN 3830

Query: 181  FVEEKLGSKYVVGRALDFATSFEESGPATPMFFILSPGVDPLKDVESQGRKLGYTFNNQN 240
            FVEEK+GSK+V GR+++F+ S+EES P+T +FFILSPGVDPLKDVE+ G+KLG+T +N  
Sbjct: 3831 FVEEKMGSKFVEGRSVEFSKSYEESSPSTSIFFILSPGVDPLKDVEALGKKLGFTIDNGK 3890

Query: 241  FHNVSLGQGQEVVAEAALDLAAKKGHWVILQ--------NIHLVAKWLSTLEKKLEEHSE 292
             HNVSLGQGQEVVAE ALD+AA+KGHWVILQ        NIHLVA+WL TL+KKLE +S 
Sbjct: 3891 LHNVSLGQGQEVVAENALDVAAEKGHWVILQVRGGQHCRNIHLVARWLGTLDKKLEHYST 3950

Query: 293  NSHPEFRVFMSAEPAPSPEGHIIPQGILENSIKITNEPPTGMHANLHKALDNFTQDTLEM 352
             SH ++RVF+SAEPAPSPE HIIPQGILEN+IKITNEPPTGMHANLHKALD FTQDTLEM
Sbjct: 3951 GSHEDYRVFISAEPAPSPETHIIPQGILENAIKITNEPPTGMHANLHKALDLFTQDTLEM 4010

Query: 353  CSRETEFKSILFALCYFHAVVAERRKFGPQGWNRSYPFNTGDLTISVNVLYNFLEANAKV 412
            C++E EFK +LFALCYFHAVVAERRKFG QGWNRSYPFN GDLTIS+NVLYN+LEAN KV
Sbjct: 4011 CTKEMEFKCMLFALCYFHAVVAERRKFGAQGWNRSYPFNNGDLTISINVLYNYLEANPKV 4070

Query: 413  PYDDLRYLFGEIMYGGHITDDWDRRLCRTYLGEFIRPEMLEGELSLAPGFPLPGNMDYNG 472
            P+DDLRYLFGEIMYGGHITDDWDRRLCRTYL E+IR EMLEG++ LAPGF +P N+DY G
Sbjct: 4071 PWDDLRYLFGEIMYGGHITDDWDRRLCRTYLAEYIRTEMLEGDVLLAPGFQIPPNLDYKG 4130

Query: 473  YHQYIDAELPPESPYLYGLHPNAEIGFLTQTSEKLFRTVLELQPRDSQARDGAGATREEK 532
            YH+YID  LPPESPYLYGLHPNAEIGFLT TSEKLFRTVLE+QP+++ +  G G +REEK
Sbjct: 4131 YHEYIDENLPPESPYLYGLHPNAEIGFLTVTSEKLFRTVLEMQPKETDSGAGTGVSREEK 4190

Query: 533  -----------------------------VKALLEEILERVTDEFNIPELMAKVEERTPY 563
                                         VKA+L++ILE++ + FN+ E+MAK  E+TPY
Sbjct: 4191 AGSLKLLPSERKGEDLELRRGGCPGTGFQVKAVLDDILEKIPETFNMAEIMAKAAEKTPY 4250

Query: 564  IVVAFQECGRMNILTREIQRSLRELELGLKGELTMTSHMENLQNALYFDMVPESWARRAY 623
            +VVAFQEC RMNILT E++RSL+EL LGLKGELT+T+ +E+L  AL++D VP++W  RAY
Sbjct: 4251 VVVAFQECERMNILTNEMRRSLKELNLGLKGELTITTDVEDLSTALFYDTVPDTWVARAY 4310

Query: 624  PSTAGLAAWFPDLLNRIKELEAWTGDFTMPSTVWLTGFFNPQSFLTAIMQSTARKNEWPL 683
            PS  GLAAW+ DLL RI+ELEAWT DF +P+TVWL GFFNPQSFLTAIMQS ARKNEWPL
Sbjct: 4311 PSMMGLAAWYADLLLRIRELEAWTTDFALPTTVWLAGFFNPQSFLTAIMQSMARKNEWPL 4370

Query: 684  DQMALQCDMTKKNREEFRSPPREGAYIHGLFMEGACWDTQAGIITEAKLKDLTPPMPVMF 743
            D+M L  ++TKKNRE+  +PPREG+Y++GLFMEGA WDTQ G+I EA+LK+LTP MPV+F
Sbjct: 4371 DKMCLSVEVTKKNREDMTAPPREGSYVYGLFMEGARWDTQTGVIAEARLKELTPAMPVIF 4430

Query: 744  IKAIPADKQDCRSVYSCPVYKTSQRGPTYVWTFNLKTKENPSKWVLAGVALLLQI 798
            IKAIP D+ + +++Y CPVYKT  RGPTYVWTFNLKTKE  +KW+LA VALLLQ+
Sbjct: 4431 IKAIPVDRMETKNIYECPVYKTRIRGPTYVWTFNLKTKEKAAKWILAAVALLLQV 4485


>gi|51479173 dynein, axonemal, heavy chain 11 [Homo sapiens]
          Length = 4523

 Score = 1094 bits (2829), Expect = 0.0
 Identities = 519/797 (65%), Positives = 646/797 (81%)

Query: 1    MNDLSKIHPMYQFSLKAFSIVFQKAVERAAPDESLRERVANLIDSITFSVYQYTIRGLFE 60
            +NDL KI+P+YQFSLKAF+++F +A+E+A   E ++ R++ L++SIT +V+ YT + LFE
Sbjct: 3726 INDLQKINPLYQFSLKAFNVLFHRAIEQADKVEDMQGRISILMESITHAVFLYTSQALFE 3785

Query: 61   CDKLTYLAQLTFQILLMNREVNAVELDFLLRSPVQTGTASPVEFLSHQAWGAVKVLSSME 120
             DKLT+L+Q+ FQILL  +E++ +ELDFLLR  V+    SPV+FL+ Q+W A+K ++ ME
Sbjct: 3786 KDKLTFLSQMAFQILLRKKEIDPLELDFLLRFTVEHTHLSPVDFLTSQSWSAIKAIAVME 3845

Query: 121  EFSNLDRDIEGSAKSWKKFVESECPEKEKLPQEWKNKTALQRLCMLRAMRPDRMTYALRD 180
            EF  +DRD+EGSAK W+K+VESECPEKEKLPQEWK K+ +Q+L +LRAMRPDRMTYALR+
Sbjct: 3846 EFRGIDRDVEGSAKQWRKWVESECPEKEKLPQEWKKKSLIQKLILLRAMRPDRMTYALRN 3905

Query: 181  FVEEKLGSKYVVGRALDFATSFEESGPATPMFFILSPGVDPLKDVESQGRKLGYTFNNQN 240
            FVEEKLG+KYV    LD   +FEES PATP+FFILSPGVD LKD+E  G++LG+T ++  
Sbjct: 3906 FVEEKLGAKYVERTRLDLVKAFEESSPATPIFFILSPGVDALKDLEILGKRLGFTIDSGK 3965

Query: 241  FHNVSLGQGQEVVAEAALDLAAKKGHWVILQNIHLVAKWLSTLEKKLEEHSENSHPEFRV 300
            FHNVSLGQGQE VAE AL+ A+K GHWVILQN+HLVAKWL TLEK LE  S+ SH ++RV
Sbjct: 3966 FHNVSLGQGQETVAEVALEKASKGGHWVILQNVHLVAKWLGTLEKLLERFSQGSHRDYRV 4025

Query: 301  FMSAEPAPSPEGHIIPQGILENSIKITNEPPTGMHANLHKALDNFTQDTLEMCSRETEFK 360
            FMSAE AP+P+ HIIPQG+LENSIKITNEPPTGM ANLH AL NF QDTLE+CS+E EFK
Sbjct: 4026 FMSAESAPTPDEHIIPQGLLENSIKITNEPPTGMLANLHAALYNFDQDTLEICSKEQEFK 4085

Query: 361  SILFALCYFHAVVAERRKFGPQGWNRSYPFNTGDLTISVNVLYNFLEANAKVPYDDLRYL 420
            SILF+LCYFHA VA R +FGPQGW+RSYPFN GDLTI  +VLYN+LEAN+KVP++DLRYL
Sbjct: 4086 SILFSLCYFHACVAGRLRFGPQGWSRSYPFNPGDLTICASVLYNYLEANSKVPWEDLRYL 4145

Query: 421  FGEIMYGGHITDDWDRRLCRTYLGEFIRPEMLEGELSLAPGFPLPGNMDYNGYHQYIDAE 480
            FGEIMYGGHITDDWDR+LCR YL EF+ P + E EL LAPGF  P  +DY GYHQYI+  
Sbjct: 4146 FGEIMYGGHITDDWDRKLCRVYLEEFMNPSLTEDELMLAPGFAAPPYLDYAGYHQYIEEM 4205

Query: 481  LPPESPYLYGLHPNAEIGFLTQTSEKLFRTVLELQPRDSQARDGAGATREEKVKALLEEI 540
            LPPESP LYGLHPNAEI FLT TS  LFRT+LE+QPR++ + D  G + EEKVK +L++I
Sbjct: 4206 LPPESPALYGLHPNAEIEFLTVTSNTLFRTLLEMQPRNALSGDELGQSTEEKVKNVLDDI 4265

Query: 541  LERVTDEFNIPELMAKVEERTPYIVVAFQECGRMNILTREIQRSLRELELGLKGELTMTS 600
            LE++ +EFN+ E+M K   R+PY++V FQEC RMNIL REI+ SL +L+L LKGEL ++ 
Sbjct: 4266 LEKLPEEFNMAEIMQKNSNRSPYVLVCFQECERMNILIREIRISLEQLDLSLKGELALSP 4325

Query: 601  HMENLQNALYFDMVPESWARRAYPSTAGLAAWFPDLLNRIKELEAWTGDFTMPSTVWLTG 660
             +E  Q AL +D VP++W++ AYPST GLA WF DLL R +EL+ WT D T+P+ VWL+G
Sbjct: 4326 AVEAQQFALSYDTVPDTWSKLAYPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVWLSG 4385

Query: 661  FFNPQSFLTAIMQSTARKNEWPLDQMALQCDMTKKNREEFRSPPREGAYIHGLFMEGACW 720
            FFNPQSFLTAIMQ+ ARKNEWPLD+  L  D+TKK +E++  PPREGAY+HGLFMEGA W
Sbjct: 4386 FFNPQSFLTAIMQTMARKNEWPLDKTRLTADVTKKTKEDYGHPPREGAYLHGLFMEGARW 4445

Query: 721  DTQAGIITEAKLKDLTPPMPVMFIKAIPADKQDCRSVYSCPVYKTSQRGPTYVWTFNLKT 780
            DTQAG I EA+LK+L  PMPV+F KA P D+Q+ +  Y CPVY+T  RGP+Y+WTF LK+
Sbjct: 4446 DTQAGTIVEARLKELACPMPVIFAKATPVDRQETKQTYECPVYRTKLRGPSYIWTFRLKS 4505

Query: 781  KENPSKWVLAGVALLLQ 797
            +E  +KWVLAGVALLL+
Sbjct: 4506 EEKTAKWVLAGVALLLE 4522


>gi|75677365 dynein heavy chain domain 3 [Homo sapiens]
          Length = 4427

 Score =  486 bits (1250), Expect = e-137
 Identities = 277/817 (33%), Positives = 440/817 (53%), Gaps = 31/817 (3%)

Query: 1    MNDLSKIHPMYQFSLKAFSIVFQKAVERAAPDESLRERVANLIDSITFSVYQYTIRGLFE 60
            +ND+  I PMYQFSL A+  +F  +++++     L +R+  L D  T++VY+YT R LFE
Sbjct: 3621 LNDMGCIDPMYQFSLDAYISLFILSIDKSHRSNKLEDRIDYLNDYHTYAVYRYTCRTLFE 3680

Query: 61   CDKLTYLAQLTFQILLMNREVNAVELDFLLRSPVQTGTASPVE-----FLSHQAWGAVKV 115
              KL +   +  +IL  + ++N  E +F LR  V       ++     +L+   W  +  
Sbjct: 3681 RHKLLFSFHMCAKILETSGKLNMDEYNFFLRGGVVLDREGQMDNPCSSWLADAYWDNITE 3740

Query: 116  LSSMEEFSNLDRDIEGSAKSWKKFVESECPEKEKLPQEWKNK-TALQRLCMLRAMRPDRM 174
            L  +  F  L    E   + W  +  +  PEK  LP EW+N    +QR+ ++R++R DR+
Sbjct: 3741 LDKLTNFHGLMNSFEQYPRDWHLWYTNAAPEKAMLPGEWENACNEMQRMLIVRSLRQDRV 3800

Query: 175  TYALRDFVEEKLGSKYVVGRALDFATSFEESGPATPMFFILSPGVDPLKDVESQGRKLGY 234
             + +  F+   LGS+++    L+  +  E+S P +P+ FILSPGVDP   +      +G 
Sbjct: 3801 AFCVTSFIITNLGSRFIEPPVLNMKSVLEDSTPRSPLVFILSPGVDPTSALLQLAEHMGM 3860

Query: 235  TFNNQNFHNVSLGQGQEVVAEAALDLAAKKGHWVILQNIHLVAKWLSTLEKKLEE-HSEN 293
                Q FH +SLGQGQ  +A   L     +GHWV L N HL   W+  L+K +E+   E+
Sbjct: 3861 A---QRFHALSLGQGQAPIAARLLREGVTQGHWVFLANCHLSLSWMPNLDKLVEQLQVED 3917

Query: 294  SHPEFRVFMSAEPAPSPEGHIIPQGILENSIKITNEPPTGMHANLHKALDNFTQDTLEMC 353
             HP FR+++S+ P P       P  IL+ SIK+T EPP G+ AN+ +     ++     C
Sbjct: 3918 PHPSFRLWLSSIPHPD-----FPISILQVSIKMTTEPPKGLKANMTRLYQLMSEPQFSRC 3972

Query: 354  SRETEFKSILFALCYFHAVVAERRKFGPQGWNRSYPFNTGDLTISVNVLYNFLEANAKVP 413
            S+  ++K +LF+LC+FH+V+ ER+KF   GWN  Y FN  D  +S N+L  +L+   + P
Sbjct: 3973 SKPAKYKKLLFSLCFFHSVLLERKKFLQLGWNIIYGFNDSDFEVSENLLSLYLDEYEETP 4032

Query: 414  YDDLRYLFGEIMYGGHITDDWDRRLCRTYLGEFIRPEMLE---GELSLAPGFPLPGNMDY 470
            +D L+YL   I YGGH+TDDWDRRL  TY+ ++   + L      LS    + +P +   
Sbjct: 4033 WDALKYLIAGINYGGHVTDDWDRRLLTTYINDYFCDQSLSTPFHRLSALETYFIPKDGSL 4092

Query: 471  NGYHQYIDAELPPESPYLYGLHPNAEIGFLTQTSEKLFRTVLELQPRDSQARDGAGATRE 530
              Y +YI      + P  +G HPNA++      ++ LF T+L LQP+ +  R G G TRE
Sbjct: 4093 ASYKEYISLLPGMDPPEAFGQHPNADVASQITEAQTLFDTLLSLQPQITPTRAG-GQTRE 4151

Query: 531  EKVKALLEEILERV---TDEFNIPELMAKVEERTPYIVVAFQECGRMNILTREIQRSLRE 587
            EKV  L  ++ +++    D     +L+A   + +P  VV  QE  R N L + I  SL +
Sbjct: 4152 EKVLELAADVKQKIPEMIDYEGTQKLLAL--DPSPLNVVLLQEIQRYNTLMQTILFSLTD 4209

Query: 588  LELGLKGELTMTSHMENLQNALYFDMVPESWARRAYPSTAGLAAWFPDLLNRIKELEAWT 647
            LE G++G + M++ +E + N ++   VP  W  +AYPS   LAAW  DL  R+++ E W 
Sbjct: 4210 LEKGIQGLIVMSTSLEEIFNCIFDAHVPPLWG-KAYPSQKPLAAWTRDLAMRVEQFELWA 4268

Query: 648  GDFTMPSTVWLTGFFNPQSFLTAIMQSTARKNEWPLDQMALQCDMTKKNREEFRSPPREG 707
                 P   WL+GF  P  FLTA++QS+AR+N   +D ++ +  ++  +      PP++G
Sbjct: 4269 SRARPPVIFWLSGFTFPTGFLTAVLQSSARQNNVSVDSLSWEFIVSTVDDSNLVYPPKDG 4328

Query: 708  AYIHGLFMEGACWDTQAGIITEAKLKDLTPPMPVMFIKAIPADKQDCRSVYSCPVYKTSQ 767
             ++ GL++EGA WD +   + EA+   L   MP +  +   + K+  + +YSCP Y    
Sbjct: 4329 VWVRGLYLEGAGWDRKNSCLVEAEPMQLVCLMPTIHFRPAESRKKSAKGMYSCPCYYYPN 4388

Query: 768  RG-----PTYVWTFNLKT-KENPSKWVLAGVALLLQI 798
            R       ++V   +L++    P  W+  G ALL+ +
Sbjct: 4389 RAGSSDRASFVIGIDLRSGAMTPDHWIKRGTALLMSL 4425


>gi|24308169 dynein, axonemal, heavy chain 3 [Homo sapiens]
          Length = 4116

 Score =  484 bits (1246), Expect = e-136
 Identities = 292/819 (35%), Positives = 439/819 (53%), Gaps = 33/819 (4%)

Query: 1    MNDLSKIHPMYQFSLKAFSIVFQKAVERAAPDESLRERVANLIDSITFSVYQYTIRGLFE 60
            ++DL+ I PMYQ+SL  F  ++  ++  +   E L  R+  +ID  T S+Y    R LFE
Sbjct: 3308 ISDLANIEPMYQYSLTWFINLYMHSLTHSTKSEELNLRIKYIIDHFTLSIYNNVCRSLFE 3367

Query: 61   CDKLTYLAQLTFQILLMNREVNAVELDFLLRSPVQTGTASP---VEFLSHQAWGAVKVLS 117
             DKL +   LT  I+   +E+      FLL   +      P    ++LS +AW  +   S
Sbjct: 3368 KDKLLFSLLLTIGIMKQKKEITEEVWYFLLTGGIALDNPYPNPAPQWLSEKAWAEIVRAS 3427

Query: 118  SMEEFSNLDRDIEGSAKSWKKFVESECPEKEKLPQEWKNKTALQRLCMLRAMRPDRMTYA 177
            ++ +   L   +E +   WK   +S  P +E+LP  WK    L+++ +LR +RPD+M  A
Sbjct: 3428 ALPKLHGLMEHLEQNLGEWKLIYDSAWPHEEQLPGSWKFSQGLEKMVILRCLRPDKMVPA 3487

Query: 178  LRDFVEEKLGSKYVVGRALDFATSFEESGPATPMFFILSPGVDPLKDVESQGRKLGYTFN 237
            +R+F+ E +G  Y+     D   S+ +S    P+ F+LSP  DP+  +      LG    
Sbjct: 3488 VREFIAEHMGKLYIEAPTFDLQGSYNDSSCCAPLIFVLSPSADPMAGLLKFADDLG--MG 3545

Query: 238  NQNFHNVSLGQGQEVVAEAALDLAAKKGHWVILQNIHLVAKWLSTLEKKLEEH--SENSH 295
                  +SLGQGQ  +A   ++ A K G WV+LQN HL A W+ TLEK  EE    E+++
Sbjct: 3546 GTRTQTISLGQGQGPIAAKMINNAIKDGTWVVLQNCHLAASWMPTLEKICEEVIVPESTN 3605

Query: 296  PEFRVFMSAEPAPSPEGHIIPQGILENSIKITNEPPTGMHANLHKA-LDNFTQDTL--EM 352
              FR+++++ P+        P  IL+N IK+TNEPP G+ ANL ++ L++   D +  + 
Sbjct: 3606 ARFRLWLTSYPSEK-----FPVSILQNGIKMTNEPPKGLRANLLRSYLNDPISDPVFFQS 3660

Query: 353  CSRETEFKSILFALCYFHAVVAERRKFGPQGWNRSYPFNTGDLTISVNVLYNFLEANAKV 412
            C++   ++ +LF LC+FHAVV ERR FGP GWN  Y FN  DL IS+  +  FL    +V
Sbjct: 3661 CAKAVMWQKMLFGLCFFHAVVQERRNFGPLGWNIPYEFNESDLRISMWQIQMFLNDYKEV 3720

Query: 413  PYDDLRYLFGEIMYGGHITDDWDRRLCRTYLGEFIRPEMLEGELSLAPG--FPLPGNMDY 470
            P+D L YL GE  YGG +TDD DRRL  + L  F   E+ E   SLAPG  + +P +  Y
Sbjct: 3721 PFDALTYLTGECNYGGRVTDDKDRRLLLSLLSMFYCKEIEEDYYSLAPGDTYYIPPHGSY 3780

Query: 471  NGYHQYIDAELPPESPYLYGLHPNAEIGFLTQTSEKLFRTVLELQPRDSQARDGAGATRE 530
              Y  Y+        P ++GLH NA+I    Q + +LF  VL   PR S    G+G + +
Sbjct: 3781 QSYIDYLRNLPITAHPEVFGLHENADITKDNQETNQLFEGVLLTLPRQS---GGSGKSPQ 3837

Query: 531  EKVKALLEEILERVTDEFNIPELMA--KVEERTPYIVVAFQECGRMNILTREIQRSLREL 588
            E V+ L ++IL ++  +F++ E+M    V        V  QE  R N LT+ ++RSL  L
Sbjct: 3838 EVVEELAQDILSKLPRDFDLEEVMKLYPVVYEESMNTVLRQELIRFNRLTKVVRRSLINL 3897

Query: 589  ELGLKGELTMTSHMENLQNALYFDMVPESWARRAYPSTAGLAAWFPDLLNRIKELEAWTG 648
               +KG++ M+S +E + N++    VP  WA ++YPS   L  +  DLL R+   + W  
Sbjct: 3898 GRAIKGQVLMSSELEEVFNSMLVGKVPAMWAAKSYPSLKPLGGYVADLLARLTFFQEWI- 3956

Query: 649  DFTMPSTVWLTGFFNPQSFLTAIMQSTARKNEWPLDQMALQCDMTKKNREEFRSPPREGA 708
            D   P   W++GF+  QSFLT + Q+ ARK   P+D +  + ++T +      + P +GA
Sbjct: 3957 DKGPPVVFWISGFYFTQSFLTGVSQNYARKYTIPIDHIGFEFEVTPQ-ETVMENNPEDGA 4015

Query: 709  YIHGLFMEGACWDTQAGIITEAKLKDLTPPMPVMFIKAIPADKQDCRSVYSCPVYKTSQR 768
            YI GLF+EGA WD +   I E+  K L  P+P++++K   +     + +Y CPVYKTS R
Sbjct: 4016 YIKGLFLEGARWDRKTMQIGESLPKILYDPLPIIWLKPGESAMFLHQDIYVCPVYKTSAR 4075

Query: 769  GPT---------YVWTFNLKTKENPSKWVLAGVALLLQI 798
              T         YV +  L T      W+  GVA L Q+
Sbjct: 4076 RGTLSTTGHSTNYVLSIELPTDMPQKHWINRGVASLCQL 4114


>gi|197927452 dynein, axonemal, heavy chain 1 [Homo sapiens]
          Length = 4265

 Score =  481 bits (1238), Expect = e-135
 Identities = 282/816 (34%), Positives = 446/816 (54%), Gaps = 36/816 (4%)

Query: 1    MNDLSKIHPMYQFSLKAFSIVFQKAVERAAPDESLRERVANLIDSITFSVYQYTIRGLFE 60
            ++DL+ + PMYQ+SL+ F  +F   +  +   ++L++R++N+   +T+S+Y    R LFE
Sbjct: 3460 VSDLANVDPMYQYSLEWFLNIFLSGIANSERADNLKKRISNINRYLTYSLYSNVCRSLFE 3519

Query: 61   CDKLTYLAQLTFQILLMNREVNAVELDFLLRS---PVQTGTASPVEFLSHQAWGAVKVLS 117
              KL +   L  +I++   ++N  E  +LL      + T   +P ++LS +AW  +  LS
Sbjct: 3520 KHKLMFAFLLCVRIMMNEGKINQSEWRYLLSGGSISIMTENPAP-DWLSDRAWRDILALS 3578

Query: 118  SMEEFSNLDRDIEGSAKSWKKFVESECPEKEKLPQEWKNKT-ALQRLCMLRAMRPDRMTY 176
            ++  FS+   D       ++   +S  P +E LP  W       Q+L +LR +R D++T 
Sbjct: 3579 NLPTFSSFSSDFVKHLSEFRVIFDSLEPHREPLPGIWDQYLDQFQKLLVLRCLRGDKVTN 3638

Query: 177  ALRDFVEEKLGSKYVVGRALDFATSFEESGPATPMFFILSPGVDPLKDVESQGRKLGYTF 236
            A++DFV   L  +++  +  + +  F++S   TP+ F+LSPG DP  D+     ++ ++ 
Sbjct: 3639 AMQDFVATNLEPRFIEPQTANLSVVFKDSNSTTPLIFVLSPGTDPAADLYKFAEEMKFS- 3697

Query: 237  NNQNFHNVSLGQGQEVVAEAALDLAAKKGHWVILQNIHLVAKWLSTLEKKLEE-HSENSH 295
              +    +SLGQGQ   AEA +  + ++G WV  QN HL   W+  LE+ +E  + +  H
Sbjct: 3698 --KKLSAISLGQGQGPRAEAMMRSSIERGKWVFFQNCHLAPSWMPALERLIEHINPDKVH 3755

Query: 296  PEFRVFMSAEPAPSPEGHIIPQGILENSIKITNEPPTGMHANLHKALDNFTQDTLEMCSR 355
             +FR+++++ P+        P  IL+N  K+T EPP G+ ANL K+  +  +D L  C +
Sbjct: 3756 RDFRLWLTSLPSNK-----FPVSILQNGSKMTIEPPRGVRANLLKSYSSLGEDFLNSCHK 3810

Query: 356  ETEFKSILFALCYFHAVVAERRKFGPQGWNRSYPFNTGDLTISVNVLYNFLEANAKVPYD 415
              EFKS+L +LC FH    ERRKFGP G+N  Y F  GDL I ++ L  FL+    +PY 
Sbjct: 3811 VMEFKSLLLSLCLFHGNALERRKFGPLGFNIPYEFTDGDLRICISQLKMFLDEYDDIPYK 3870

Query: 416  DLRYLFGEIMYGGHITDDWDRRLCRTYLGEFIRPEMLEGELSLAPG---FPLPGNMDYNG 472
             L+Y  GEI YGG +TDDWDRR     L +F  P++L  E S +       +P   D +G
Sbjct: 3871 VLKYTAGEINYGGRVTDDWDRRCIMNILEDFYNPDVLSPEHSYSASGIYHQIPPTYDLHG 3930

Query: 473  YHQYIDAELPPESPYLYGLHPNAEIGFLTQTSEKLFRTVLELQPRDSQARDGAGATREEK 532
            Y  YI +    + P ++GLH NA I F    +  L  T+++LQP+ S A       REE 
Sbjct: 3931 YLSYIKSLPLNDMPEIFGLHDNANITFAQNETFALLGTIIQLQPKSSSA---GSQGREEI 3987

Query: 533  VKALLEEILERVTDEFNIPELMAK----VEERTPYIVVAFQECGRMNILTREIQRSLREL 588
            V+ + + IL +V +  N+  +MAK     EE    ++V  QE  R N L + I ++L++L
Sbjct: 3988 VEDVTQNILLKVPEPINLQWVMAKYPVLYEESMNTVLV--QEVIRYNRLLQVITQTLQDL 4045

Query: 589  ELGLKGELTMTSHMENLQNALYFDMVPESWARRAYPSTAGLAAWFPDLLNRIKELEAWTG 648
               LKG + M+S +E +  +LY + VPE W+ +AYPS   L++W  DLL R+  L+AW  
Sbjct: 4046 LKALKGLVVMSSQLELMAASLYNNTVPELWSAKAYPSLKPLSSWVMDLLQRLDFLQAWIQ 4105

Query: 649  DFTMPSTVWLTGFFNPQSFLTAIMQSTARKNEWPLDQMALQCDMTKKNREEFRSPPREGA 708
            D  +P+  W++GFF PQ+FLT  +Q+ ARK    +D ++    +  +   E    P+ G 
Sbjct: 4106 D-GIPAVFWISGFFFPQAFLTGTLQNFARKFVISIDTISFDFKVMFEAPSELTQRPQVGC 4164

Query: 709  YIHGLFMEGACWDTQAGIITEAKLKDLTPPMPVMFIKAIPADKQDCRSVYSCPVYKTSQR 768
            YIHGLF+EGA WD +A  + E++ K+L   M V+++   P  K   +  Y CP+YKT  R
Sbjct: 4165 YIHGLFLEGARWDPEAFQLAESQPKELYTEMAVIWLLPTPNRKAQDQDFYLCPIYKTLTR 4224

Query: 769  GPT---------YVWTFNLKTKENPSKWVLAGVALL 795
              T         YV    + T +    W+  GVAL+
Sbjct: 4225 AGTLSTTGHSTNYVIAVEIPTHQPQRHWIKRGVALI 4260


>gi|151301127 dynein, axonemal, heavy chain 7 [Homo sapiens]
          Length = 4024

 Score =  478 bits (1230), Expect = e-135
 Identities = 284/824 (34%), Positives = 446/824 (54%), Gaps = 48/824 (5%)

Query: 3    DLSKIHPMYQFSLKAFSIVFQKAVERAAPDESLRERVANLIDSITFSVYQYTIRGLFECD 62
            DL+ I PMYQ+SL  F  +F  ++E +   E L +R+  L D  T+S+Y    R LFE D
Sbjct: 3219 DLANIEPMYQYSLTWFINLFILSIENSEKSEILAKRLQILKDHFTYSLYVNVCRSLFEKD 3278

Query: 63   KLTYLAQLTFQILLMNREVNAVELDFLLRSPVQTGT--ASPVEFLSHQAWGAVKVLSSME 120
            KL +   LT  +LL  R +N  E  FLL   +      A+   +L  ++W  +  L  + 
Sbjct: 3279 KLLFSFCLTINLLLHERAINKAEWRFLLTGGIGLDNPYANLCTWLPQKSWDEICRLDDLP 3338

Query: 121  EFSNLDRDIEGSAKSWKKFVESECPEKEKLPQEWKNKT-ALQRLCMLRAMRPDRMTYALR 179
             F  + R+       WKK  +S  P  E  P+EW++K    QR+ ++R +RPD++   L+
Sbjct: 3339 AFKTIRREFMRLKDGWKKVYDSLEPHHEVFPEEWEDKANEFQRMLIIRCLRPDKVIPMLQ 3398

Query: 180  DFVEEKLGSKYVVGRALDFATSFEESGPATPMFFILSPGVDP----LKDVESQGRKLGYT 235
            +F+  +LG  ++     D A +F +S    P+ F+LSPG DP    LK  + QG      
Sbjct: 3399 EFIINRLGRAFIEPPPFDLAKAFGDSNCCAPLIFVLSPGADPMAALLKFADDQG------ 3452

Query: 236  FNNQNFHNVSLGQGQEVVAEAALDLAAKKGHWVILQNIHLVAKWLSTLEKKLEEHS-ENS 294
            +      ++SLGQGQ  +A   L+ A K+G WV+LQN HL   W+ TLEK  EE S E++
Sbjct: 3453 YGGSKLSSLSLGQGQGPIAMKMLEKAVKEGTWVVLQNCHLATSWMPTLEKVCEELSPEST 3512

Query: 295  HPEFRVFMSAEPAPSPEGHIIPQGILENSIKITNEPPTGMHANLHKA--LDNFTQ-DTLE 351
            HP+FR+++++ P+P+      P  +L+N +K+TNE P G+ AN+ ++  +D  +  +   
Sbjct: 3513 HPDFRMWLTSYPSPN-----FPVSVLQNGVKMTNEAPKGLRANIIRSYLMDPISDPEFFG 3567

Query: 352  MCSRETEFKSILFALCYFHAVVAERRKFGPQGWNRSYPFNTGDLTISVNVLYNFLEANAK 411
             C +  EFK +L+ LC+FHA+V ERRKFGP GWN  Y FN  DL ISV  L+ FL    +
Sbjct: 3568 SCKKPEEFKKLLYGLCFFHALVQERRKFGPLGWNIPYEFNETDLRISVQQLHMFLNQYEE 3627

Query: 412  VPYDDLRYLFGEIMYGGHITDDWDRRLCRTYLGEFIRPEMLEG---ELSLAPGFPLPGNM 468
            +PY+ LRY+ GE  YGG +TDDWDRR  R+ L +F  PE++E    +   +  + +P + 
Sbjct: 3628 LPYEALRYMTGECNYGGRVTDDWDRRTLRSILNKFFNPELVENSDYKFDSSGIYFVPPSG 3687

Query: 469  DYNGYHQYIDAELPPESPYLYGLHPNAEIGFLTQTSEKLFRTVLELQPRDSQARDGAGA- 527
            D+  Y +Y        +P ++G++ NA+I      ++ LF  +L  Q R +    GAGA 
Sbjct: 3688 DHKSYIEYTKTLPLTPAPEIFGMNANADITKDQSETQLLFDNILLTQSRSA----GAGAK 3743

Query: 528  TREEKVKALLEEILERVTDEFNIPELMAKVEERTPYI----VVAFQECGRMNILTREIQR 583
            + +E V  +  +IL ++ + F+I   M +    T Y      V  QE GR N L + I+ 
Sbjct: 3744 SSDEVVNEVASDILGKLPNNFDIEAAMRRYP--TTYTQSMNTVLVQEMGRFNKLLKTIRD 3801

Query: 584  SLRELELGLKGELTMTSHMENLQNALYFDMVPESWARRAYPSTAGLAAWFPDLLNRIKEL 643
            S   ++  +KG   M++ +E + +++    +PE W  ++YPS   L ++  D L R+K L
Sbjct: 3802 SCVNIQKAIKGLAVMSTDLEEVVSSILNVKIPEMWMGKSYPSLKPLGSYVNDFLARLKFL 3861

Query: 644  EAWTGDFTMPSTVWLTGFFNPQSFLTAIMQSTARKNEWPLDQMALQCDMTKKNREEFRSP 703
            + W  +   P   WL+GFF  Q+FLT   Q+ ARK   P+D +    ++ +   +E++ P
Sbjct: 3862 QQWY-EVGPPPVFWLSGFFFTQAFLTGAQQNYARKYTIPIDLLGFDYEVMED--KEYKHP 3918

Query: 704  PREGAYIHGLFMEGACWDTQAGIITEAKLKDLTPPMPVMFIKAIPADKQDCRSVYSCPVY 763
            P +G +IHGLF++GA W+ +   + E+  K L   +PVM++K         R  Y  P+Y
Sbjct: 3919 PEDGVFIHGLFLDGASWNRKIKKLAESHPKILYDTVPVMWLKPCKRADIPKRPSYVAPLY 3978

Query: 764  KTSQR---------GPTYVWTFNLKTKENPSKWVLAGVALLLQI 798
            KTS+R            +V    L + +    W+  GVALL Q+
Sbjct: 3979 KTSERRGVLSTTGHSTNFVIAMTLPSDQPKEHWIGRGVALLCQL 4022


>gi|198442844 dynein, axonemal, heavy chain 10 [Homo sapiens]
          Length = 4471

 Score =  478 bits (1229), Expect = e-134
 Identities = 272/822 (33%), Positives = 456/822 (55%), Gaps = 41/822 (4%)

Query: 1    MNDLSKIHPMYQFSLKAFSIVFQKAVERAAPDESLRERVANLIDSITFSVYQYTIRGLFE 60
            +++++ ++ MYQ+SL AF  VF+ +++++ PD  L +R+ N++D++TFS+Y +   GLFE
Sbjct: 3662 LSEMALVNSMYQYSLIAFLEVFRLSLKKSLPDSILMKRLRNIMDTLTFSIYNHGCTGLFE 3721

Query: 61   CDKLTYLAQLTFQILLMNREVNAVELDFLLRSPV---QTGTASPVEFLSHQAWGAVKVLS 117
              KL +   +T +I      V   ELDF L+  +   ++    P  +LS Q W  + +LS
Sbjct: 3722 RHKLLFSFNMTIKIEQAEGRVPQEELDFFLKGNISLEKSKRKKPCAWLSDQGWEDIILLS 3781

Query: 118  SM--EEFSNLDRDIEGSAKSWKKFVESECPEKEKLPQEWKNK-TALQRLCMLRAMRPDRM 174
             M  + F  L  D+E +   W+++ + +  E+  +P  + N  T  Q+L +LR  R DR+
Sbjct: 3782 EMFSDNFGQLPDDVENNQTVWQEWYDLDSLEQFPVPLGYDNNITPFQKLLILRCFRVDRV 3841

Query: 175  TYALRDFVEEKLGSKYVVGRALDFATSFEESGPATPMFFILSPGVDPLKDVESQGRKLGY 234
              A+ D+V   +G KYV    + F   FE+S P +P+ FILSPG DP  D+     + G+
Sbjct: 3842 YRAVTDYVTVTMGEKYVQPPMISFEAIFEQSTPHSPIVFILSPGSDPATDLMKLAERSGF 3901

Query: 235  TFNNQNFHNVSLGQGQEVVAEAALDLAAKKGHWVILQNIHLVAKWLSTLEKKLEEHSENS 294
              N   F  +++GQGQE VA   L+ A  +G W++LQN HL+ KWL  LEK LE  ++  
Sbjct: 3902 GGNRLKF--LAMGQGQEKVALQLLETAVARGQWLMLQNCHLLVKWLKDLEKSLERITK-P 3958

Query: 295  HPEFRVFMSAEPAPSPEGHIIPQGILENSIKITNEPPTGMHANLHKALDNFTQDTLEMCS 354
            HP+FR++++ +P         P GIL+ S+K+  EPP G+  N+       + + L+ C 
Sbjct: 3959 HPDFRLWLTTDPTKG-----FPIGILQKSLKVVTEPPNGLKLNMRATYFKISHEMLDQCP 4013

Query: 355  RETEFKSILFALCYFHAVVAERRKFGPQGWNRSYPFNTGDLTISVNVLYNFL-----EAN 409
                FK +++ L +FHAVV ERRKFG  GWN  Y FN  D  + + +L  +L     + +
Sbjct: 4014 HPA-FKPLVYVLAFFHAVVQERRKFGKIGWNVYYDFNESDFQVCMEILNTYLTKAFQQRD 4072

Query: 410  AKVPYDDLRYLFGEIMYGGHITDDWDRRLCRTYLGEFIRPEMLEGELSLAP--------- 460
             ++P+  L+YL GE+MYGG   D +DRR+   Y+ E++   + +   +  P         
Sbjct: 4073 PRIPWGSLKYLIGEVMYGGRAIDSFDRRILTIYMDEYLGDFIFD---TFQPFHFFRNKEV 4129

Query: 461  GFPLPGNMDYNGYHQYIDAELPPESPYLYGLHPNAEIGFLTQTSEKLFRTVLELQPRDSQ 520
             + +P   +   + + I+A     +P ++GLHPNAEIG+ TQ +  ++  +LELQP+  +
Sbjct: 4130 DYKIPVGDEKEKFVEAIEALPLANTPEVFGLHPNAEIGYYTQAARDMWAHLLELQPQTGE 4189

Query: 521  ARDGAGATREEKVKALLEEILERVTDEFNIPELMAKV-EERTPYIVVAFQECGRMNILTR 579
            +   +G +R++ +  + +EI  ++   F++ ++  ++    +P  VV  QE  R N L  
Sbjct: 4190 S--SSGISRDDYIGQVAKEIENKMPKVFDLDQVRKRLGTGLSPTSVVLLQELERFNKLVV 4247

Query: 580  EIQRSLRELELGLKGELTMTSHMENLQNALYFDMVPESWARRAYPSTAGLAAWFPDLLNR 639
             + +SL EL+  L GE+ M++ ++++  +L+   +P  W R A  +   L  W    L R
Sbjct: 4248 RMTKSLAELQRALAGEVGMSNELDDVARSLFIGHIPNIWRRLAPDTLKSLGNWMVYFLRR 4307

Query: 640  IKELEAWTGDFTMPSTVWLTGFFNPQSFLTAIMQSTARKNEWPLDQMALQCDMTK-KNRE 698
              +   W  + + PS +WL+G   P+S+LTA++Q+T RKN WPLD+  L   +TK ++ +
Sbjct: 4308 FSQYMLWVTE-SEPSVMWLSGLHIPESYLTALVQATCRKNGWPLDRSTLFTQVTKFQDAD 4366

Query: 699  EFRSPPREGAYIHGLFMEGACWDTQAGIITEAKLKDLTPPMPVMFIKAIPADKQDCRSVY 758
            E      +G ++ GL++EGA WD + G + ++K K L   +P++ I  I A +   ++ +
Sbjct: 4367 EVNERAGQGCFVSGLYLEGADWDIEKGCLIKSKPKVLVVDLPILKIIPIEAHRLKLQNTF 4426

Query: 759  SCPVYKTSQR----GPTYVWTFNLKTKENPSKWVLAGVALLL 796
              PVY TS R    G   V+  +L T  + S WVL GV L L
Sbjct: 4427 RTPVYTTSMRRNAMGVGLVFEADLFTTRHISHWVLQGVCLTL 4468


>gi|19115954 dynein, axonemal, heavy chain 5 [Homo sapiens]
          Length = 4624

 Score =  445 bits (1144), Expect = e-125
 Identities = 265/811 (32%), Positives = 433/811 (53%), Gaps = 30/811 (3%)

Query: 1    MNDLSKIHPMYQFSLKAFSIVFQKAVERAAPDESLRERVANLIDSITFSVYQYTIRGLFE 60
            + ++  ++ MYQ SL+ F  +F  ++ R+       +R+AN+I+ +T+ VY+Y  RGL+E
Sbjct: 3830 ITEMRLVNEMYQTSLRQFLGLFDLSLARSVKSPITSKRIANIIEHMTYEVYKYAARGLYE 3889

Query: 61   CDKLTYLAQLTFQILLMNREVNAVELDFLLRS----PVQTGTASPVEFLSHQAWGAVKVL 116
              K  +   LT +I +    V   E   L++      ++     P +++    W  +  L
Sbjct: 3890 EHKFLFTLLLTLKIDIQRNRVKHEEFLTLIKGGASLDLKACPPKPSKWILDITWLNLVEL 3949

Query: 117  SSMEEFSNLDRDIEGSAKSWKKFVESECPEKEKLPQEW-KNKTALQRLCMLRAMRPDRMT 175
            S + +FS++   I  + K WK + + E PE+E LP  + K+    +RL ++R+  PDR  
Sbjct: 3950 SKLRQFSDVLDQISRNEKMWKIWFDKENPEEEPLPNAYDKSLDCFRRLLLIRSWCPDRTI 4009

Query: 176  YALRDFVEEKLGSKYVVGRALDFATSFEESGPATPMFFILSPGVDPLKDVESQGRKLGYT 235
               R ++ + +G KY  G  LD   ++EES P TP+  +LS G DP   + + G++L   
Sbjct: 4010 AQARKYIVDSMGEKYAEGVILDLEKTWEESDPRTPLICLLSMGSDPTDSIIALGKRLKI- 4068

Query: 236  FNNQNFHNVSLGQGQEVVAEAALDLAAKKGHWVILQNIHLVAKWLSTLEKKLEEHSENSH 295
                    VS+GQGQEV A   L      G W +LQN HL   ++  L   + E +E  H
Sbjct: 4069 ----ETRYVSMGQGQEVHARKLLQQTMANGGWALLQNCHLGLDFMDELMDIIIE-TELVH 4123

Query: 296  PEFRVFMSAEPAPSPEGHIIPQGILENSIKITNEPPTGMHANLHKALDNFTQDTLEMCSR 355
              FR++M+ E          P  +L+ SIK  N+PP G+ A L +     +QD L++ S 
Sbjct: 4124 DAFRLWMTTEAHKQ-----FPITLLQMSIKFANDPPQGLRAGLKRTYSGVSQDLLDVSSG 4178

Query: 356  ETEFKSILFALCYFHAVVAERRKFGPQGWNRSYPFNTGDLTISVNVLYNFLE---ANAKV 412
             +++K +L+A+ + H+ V ERRKFG  GWN  Y FN  D   +V  + N L+       V
Sbjct: 4179 -SQWKPMLYAVAFLHSTVQERRKFGALGWNIPYEFNQADFNATVQFIQNHLDDMDVKKGV 4237

Query: 413  PYDDLRYLFGEIMYGGHITDDWDRRLCRTYLGEFIRPEMLEGELSLAPGFPLPGNMDYNG 472
             +  +RY+ GEI YGG +TDD+D+RL  T+   +    M   + S   G+ +P     + 
Sbjct: 4238 SWTTIRYMIGEIQYGGRVTDDYDKRLLNTFAKVWFSENMFGPDFSFYQGYNIPKCSTVDN 4297

Query: 473  YHQYIDAELPPESPYLYGLHPNAEIGFLTQTSEKLFRTVLELQPRDSQARDGAGATREEK 532
            Y QYI +    +SP ++GLHPNA+I + ++ ++ +  T+L +QP+D+    G   TRE  
Sbjct: 4298 YLQYIQSLPAYDSPEVFGLHPNADITYQSKLAKDVLDTILGIQPKDTSG--GGDETREAV 4355

Query: 533  VKALLEEILERVTDE---FNIPELMAKVEERTPYIVVAFQECGRMNILTREIQRSLRELE 589
            V  L +++LE++  +   F + E + K+    P  +   QE  RM  +   ++ +L EL+
Sbjct: 4356 VARLADDMLEKLPPDYVPFEVKERLQKMGPFQPMNIFLRQEIDRMQRVLSLVRSTLTELK 4415

Query: 590  LGLKGELTMTSHMENLQNALYFDMVPESWARRAYPSTAGLAAWFPDLLNRIKELEAWTGD 649
            L + G + M+ ++ +  + ++   +P  W + ++ S+  L  WF +L+ R  +  +W  +
Sbjct: 4416 LAIDGTIIMSENLRDALDCMFDARIPAWWKKASWISST-LGFWFTELIERNSQFTSWVFN 4474

Query: 650  FTMPSTVWLTGFFNPQSFLTAIMQSTARKNE-WPLDQMALQCDMTKKNREEFRSPPREGA 708
               P   W+TGFFNPQ FLTA+ Q   R N+ W LD M L  ++TK  +++  +PP EG 
Sbjct: 4475 -GRPHCFWMTGFFNPQGFLTAMRQEITRANKGWALDNMVLCNEVTKWMKDDISAPPTEGV 4533

Query: 709  YIHGLFMEGACWDTQAGIITEAKLKDLTPPMPVMFIKAIPADKQDCRSVYSCPVYKTSQR 768
            Y++GL++EGA WD +   + E+K K L   MPV+ I A     +D R  YSCP+YK   R
Sbjct: 4534 YVYGLYLEGAGWDKRNMKLIESKPKVLFELMPVIRIYAENNTLRDPR-FYSCPIYKKPVR 4592

Query: 769  GP-TYVWTFNLKTKENPSKWVLAGVALLLQI 798
                Y+   +L+T + P  WVL GVALL  +
Sbjct: 4593 TDLNYIAAVDLRTAQTPEHWVLRGVALLCDV 4623


>gi|126012497 dynein, axonemal, heavy polypeptide 8 [Homo sapiens]
          Length = 4490

 Score =  444 bits (1143), Expect = e-124
 Identities = 253/811 (31%), Positives = 436/811 (53%), Gaps = 29/811 (3%)

Query: 1    MNDLSKIHPMYQFSLKAFSIVFQKAVERAAPDESLRERVANLIDSITFSVYQYTIRGLFE 60
            + ++S ++ MYQ SL  F  +F +++ R+      ++R+ N+I+ +T+ V+ Y++RGL+E
Sbjct: 3695 ITEMSMVNIMYQTSLAQFLKLFDQSMARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYE 3754

Query: 61   CDKLTYLAQLTFQILLMNREVNAVELDFLLRS----PVQTGTASPVEFLSHQAWGAVKVL 116
              K  ++  +T +I L    V   E   L++      ++     P  ++    W  +  L
Sbjct: 3755 NHKFLFVLLMTLKIDLQRGTVKHREFQALIKGGAALDLKACPPKPYRWILDMTWLNLVEL 3814

Query: 117  SSMEEFSNLDRDIEGSAKSWKKFVESECPEKEKLPQEWKNKT-ALQRLCMLRAMRPDRMT 175
            S + +F+ +   I  + K WK + + + PE+E +P  + +      +L ++R+  PDR  
Sbjct: 3815 SKLPQFAEIMNQISRNEKGWKSWFDKDAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTV 3874

Query: 176  YALRDFVEEKLGSKYVVGRALDFATSFEESGPATPMFFILSPGVDPLKDVESQGRKLGYT 235
            +  R ++ + L  KY     L+   ++EES   TP+   LS G DP   +++  +KL   
Sbjct: 3875 FQARKYIADSLEEKYTEPVILNLEKTWEESDTRTPLICFLSMGSDPTNQIDALAKKL--- 3931

Query: 236  FNNQNFHNVSLGQGQEVVAEAALDLAAKKGHWVILQNIHLVAKWLSTLEKKLEEHSENSH 295
                    +S+GQGQEV A   + ++ ++G WV+LQN HL  +++  L + L   +E S 
Sbjct: 3932 --KLECRTISMGQGQEVHARKLIQMSMQQGGWVLLQNCHLGLEFMEELLETLIT-TEASD 3988

Query: 296  PEFRVFMSAEPAPSPEGHIIPQGILENSIKITNEPPTGMHANLHKALDNFTQDTLEMCSR 355
              FRV+++ EP         P  +L+ S+K TNEPP G+ A L +      QD L++ S 
Sbjct: 3989 DSFRVWITTEPHDR-----FPITLLQTSLKFTNEPPQGVRAGLKRTFAGINQDLLDI-SN 4042

Query: 356  ETEFKSILFALCYFHAVVAERRKFGPQGWNRSYPFNTGDLTISVNVLYNFL-EANAK--V 412
               +K +L+ + + H+ V ERRKFGP GWN  Y FN+ D + SV  + N L E + K  V
Sbjct: 4043 LPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSADFSASVQFIQNHLDECDIKKGV 4102

Query: 413  PYDDLRYLFGEIMYGGHITDDWDRRLCRTYLGEFIRPEMLEGELSLAPGFPLPGNMDYNG 472
             ++ +RY+ GE+ YGG +TDD+D+RL   +   +   +M E       G+ +P     + 
Sbjct: 4103 SWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEKMFEPSFCFYTGYKIPLCKTLDQ 4162

Query: 473  YHQYIDAELPPESPYLYGLHPNAEIGFLTQTSEKLFRTVLELQPRDSQARDGAGATREEK 532
            Y +YI +    ++P ++GLHPNA+I + + T+  +  T+  +QP++S    G G TRE  
Sbjct: 4163 YFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLETITNIQPKESGG--GVGETREAI 4220

Query: 533  VKALLEEILERVTDEF---NIPELMAKVEERTPYIVVAFQECGRMNILTREIQRSLRELE 589
            V  L E++L ++  ++    +   + K+       +   QE  RM  +   ++ SL +L+
Sbjct: 4221 VYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQEIDRMQRVISILRSSLSDLK 4280

Query: 590  LGLKGELTMTSHMENLQNALYFDMVPESWARRAYPSTAGLAAWFPDLLNRIKELEAWTGD 649
            L ++G + M+ ++ +  + +Y   +P+ W R ++ S+  L  WF +LL R  +   W  +
Sbjct: 4281 LAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSST-LGFWFTELLERNAQFSTWIFE 4339

Query: 650  FTMPSTVWLTGFFNPQSFLTAIMQSTARKNE-WPLDQMALQCDMTKKNREEFRSPPREGA 708
               P+  W+TGFFNPQ FLTA+ Q   R ++ W LD + +  ++ ++ +EE  SPP EG 
Sbjct: 4340 -GRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHNEVLRQTKEEITSPPGEGV 4398

Query: 709  YIHGLFMEGACWDTQAGIITEAKLKDLTPPMPVMFIKAIPADKQDCRSVYSCPVYKTSQR 768
            YI+GL+M+GA WD + G + E+  K L   +PV+ I AI +       +Y CP+YK  +R
Sbjct: 4399 YIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINSTAPKDPKLYVCPIYKKPRR 4458

Query: 769  GP-TYVWTFNLKTKENPSKWVLAGVALLLQI 798
               T++    L+T  +P  W+L GVALL  I
Sbjct: 4459 TDLTFITVVYLRTVLSPDHWILRGVALLCDI 4489


>gi|194440727 dynein heavy chain domain 2 isoform 1 [Homo sapiens]
          Length = 3092

 Score =  435 bits (1118), Expect = e-122
 Identities = 272/824 (33%), Positives = 423/824 (51%), Gaps = 43/824 (5%)

Query: 3    DLSKIHPMYQFSLKAFSIVFQKAVERAAPDES--LRERVANLIDSITFSVYQYTIRGLFE 60
            ++SK + M ++     S +      R   ++S  L +R+  L D  T+++Y    R LFE
Sbjct: 2282 EISKSYGMNEWREDMKSFIAVPVTNRIVDNKSKILEKRLRYLNDHFTYNLYCNICRSLFE 2341

Query: 61   CDKLTYLAQLTFQILLMNREVNAVELDFLLRSPVQTGTASP---VEFLSHQAWGAVKVLS 117
             DKL +   L   +LL  +E+   EL FLL   V   +A       +L  ++W  +   S
Sbjct: 2342 KDKLLFSFLLCANLLLARKEIEYQELMFLLTGGVSLKSAEKNPDPTWLQDKSWEEICRAS 2401

Query: 118  SMEEFSNLDRDIEGSAKSWKKFVESECPEKEKLPQEW-KNKTALQRLCMLRAMRPDRMTY 176
                F  L +        W++  +S+ P   K P    KN   LQ++ +LR +RPD++T 
Sbjct: 2402 EFPAFRGLRQHFCEHIYEWREIYDSKEPHNAKFPAPMDKNLNELQKIIILRCLRPDKITP 2461

Query: 177  ALRDFVEEKLGSKYVVGRALDFATSFEESGPATPMFFILSPGVDPLKDVESQGRKLGYTF 236
            A+ ++V +KLG K+V     D   S+ +S    P+ F+LSPG DP+  +         + 
Sbjct: 2462 AITNYVTDKLGKKFVEPPPFDLTKSYLDSNCTIPLIFVLSPGADPMASLLKFANDKSMSG 2521

Query: 237  NNQNFHNVSLGQGQEVVAEAALDLAAKKGHWVILQNIHLVAKWLSTLEKKLEEH-SENSH 295
            N   F  +SLGQGQ  +A   +  A ++G WV LQN HL   W+  LEK  E+  SE  +
Sbjct: 2522 NK--FQAISLGQGQGPIAAKMIKAAIEEGTWVCLQNCHLAVSWMPMLEKICEDFTSETCN 2579

Query: 296  PEFRVFMSAEPAPSPEGHIIPQGILENSIKITNEPPTGMHANLHKALDNFTQDTLE---- 351
              FR+++++ P+        P  IL+N +K+TNEPPTG+  NL   L ++  D +     
Sbjct: 2580 SSFRLWLTSYPSSK-----FPVTILQNGVKMTNEPPTGLRLNL---LQSYLTDPVSDPEF 2631

Query: 352  ---MCSRETEFKSILFALCYFHAVVAERRKFGPQGWNRSYPFNTGDLTISVNVLYNFLEA 408
                  +E  ++ +LF +C+FHA+V ER+KFGP GWN  Y FN  DL IS+  L  F+  
Sbjct: 2632 FKGCRGKELAWEKLLFGVCFFHALVQERKKFGPLGWNIPYGFNESDLRISIRQLQLFINE 2691

Query: 409  NAKVPYDDLRYLFGEIMYGGHITDDWDRRLCRTYLGEFIRPEMLEG---ELSLAPGFPLP 465
               +P++ + YL GE  YGG +TDDWDRRL  T L +F    ++E    + S +  +  P
Sbjct: 2692 YDTIPFEAISYLTGECNYGGRVTDDWDRRLLLTMLADFYNLYIVENPHYKFSPSGNYFAP 2751

Query: 466  GNMDYNGYHQYIDAELPPESPYLYGLHPNAEIGFLTQTSEKLFRTVLELQPRDSQARDGA 525
                Y  Y ++I      + P ++GLH N +I    Q ++ LF ++L  Q    Q   GA
Sbjct: 2752 PKGTYEDYIEFIKKLPFTQHPEIFGLHENVDISKDLQQTKTLFESLLLTQGGSKQT--GA 2809

Query: 526  GATREEKVKALLEEILERVTDEFNIPELMAK--VEERTPYIVVAFQECGRMNILTREIQR 583
              + ++ +  + ++IL ++  +F+I   + K  V        V  QE  R N L   I+ 
Sbjct: 2810 SGSTDQILLEITKDILNKLPSDFDIEMALRKYPVRYEESMNTVLVQEMERFNNLIITIRN 2869

Query: 584  SLRELELGLKGELTMTSHMENLQNALYFDMVPESWARRAYPSTAGLAAWFPDLLNRIKEL 643
            +LR+LE  +KG + M S +E L  +L    VPE WA+R+YPS   L ++  D L R+  L
Sbjct: 2870 TLRDLEKAIKGVVVMDSALEALSGSLLVGKVPEIWAKRSYPSLKPLGSYITDFLARLNFL 2929

Query: 644  EAWTGDFTMPSTVWLTGFFNPQSFLTAIMQSTARKNEWPLDQMALQCDMTKKNREEFRSP 703
            + W      P   WL+GFF  Q+FLT  MQ+ ARK   P+D +  + ++   +  +  + 
Sbjct: 2930 QDWYNS-GKPCVFWLSGFFFTQAFLTGAMQNYARKYTTPIDLLGYEFEVIPSDTSD--TS 2986

Query: 704  PREGAYIHGLFMEGACWDTQAGIITEAKLKDLTPPMPVMFIKAIPADKQDCRSVYSCPVY 763
            P +G YIHGL+++GA WD ++G++ E   K L   MP+++IK     +      Y CP+Y
Sbjct: 2987 PEDGVYIHGLYLDGARWDRESGLLAEQYPKLLFDLMPIIWIKPTQKSRIIKSDAYVCPLY 3046

Query: 764  KTSQRGPT---------YVWTFNLKTKENPSKWVLAGVALLLQI 798
            KTS+R  T         +V    LKT +    W+  GVALL Q+
Sbjct: 3047 KTSERKGTLSTTGHSTNFVIAMLLKTDQPTRHWIKRGVALLCQL 3090


>gi|194353966 dynein, axonemal, heavy polypeptide 6 [Homo sapiens]
          Length = 4158

 Score =  400 bits (1027), Expect = e-111
 Identities = 256/865 (29%), Positives = 423/865 (48%), Gaps = 86/865 (9%)

Query: 4    LSKIHPMYQFSLKAFSIVFQKAVERAAPDESLRERVANLIDSITFSVYQYTIRGLFECDK 63
            LS+I PMYQ+SLK F  +F   +E +   E+L++R+  L++    + Y    RGLFE  K
Sbjct: 3308 LSEIDPMYQYSLKYFKQLFNTTIETSVKTENLQQRLDVLLEQTLLTAYVNVSRGLFEQHK 3367

Query: 64   LTYLAQLTFQILLMNREVNAVELDFLLRSPVQTGTASPVE----FLSHQAWGAVKVLS-S 118
            L Y   L  +++     ++  E +F LR         P +    +L    W A   L  S
Sbjct: 3368 LIYSFMLCVEMMRQQGTLSDAEWNFFLRGSAGLEKERPPKPEAPWLPTATWFACCDLEES 3427

Query: 119  MEEFSNLDRDIEG--------------SAKSWKKFVESECP------EKEKLPQE-WK-N 156
               F  L ++I                + + W+ + + +        EKE   Q+ W   
Sbjct: 3428 FPVFHGLTQNILSHPISIRLGSFETYINPQKWEGYSKMKHEDKHMRQEKEAAHQDPWSAG 3487

Query: 157  KTALQRLCMLRAMRPDRMTYALRDFVEEKLGSKYVVGRALDFATSFEESGPATPMFFILS 216
             ++  +L +++  + +++ +AL DFV E LG +++    +D  T +++    TP+ FILS
Sbjct: 3488 LSSFHKLILIKCCKEEKVVFALTDFVIENLGKQFIETPPVDLPTLYQDMSCNTPLVFILS 3547

Query: 217  PGVDPLKDVESQGRKLGYTFNNQNFHNVSLGQGQEVVAEAALDLAAKKGHWVILQNIHLV 276
             G DP+   +   R+ GY+   +   ++SLGQGQ  +AE  +  A K G+WV LQN HL 
Sbjct: 3548 TGSDPMGAFQRFARESGYS---ERVQSISLGQGQGPIAEKMVKDAMKSGNWVFLQNCHLA 3604

Query: 277  AKWLSTLEKKLEEHSENSHP---EFRVFMSAEPAPSPEGHIIPQGILENSIKITNEPPTG 333
              W+  +E+ ++  ++        FR+F+S+ P+     +  P  +L+NS+K+TNEPP G
Sbjct: 3605 VSWMLAMEELIKTFTDPDSAIKDTFRLFLSSMPS-----NTFPVTVLQNSVKVTNEPPKG 3659

Query: 334  MHANLHKALDNFTQDTLEMCSRETEFKSILFALCYFHAVVAERRKFGPQGWNRSYPFNTG 393
            + AN+ +A    T    E      +++ I+F +C+FHA++ ER+KFGP GWN  Y FN  
Sbjct: 3660 LRANIRRAFTEMTPSFFEENILGKKWRQIIFGICFFHAIIQERKKFGPLGWNICYEFNDS 3719

Query: 394  DLTISVNVLYNFLEANAKVPYDDLRYLFGEIMYGGHITDDWDRRLCRTYLGEFIRPEMLE 453
            D   ++  L  + +   K+P+D L Y+ GEI YGG +TD WD+R  RT L  F  PE LE
Sbjct: 3720 DRECALLNLKLYCK-EGKIPWDALIYITGEITYGGRVTDSWDQRCLRTILKRFFSPETLE 3778

Query: 454  GELSLAPG--FPLPGNMDYNGYHQYIDAELPPESPYLYGLHPNAEIGFLTQTSEKLFRTV 511
             +   +    +  P       +  YI+     + P ++G+H NA + F  + +  L  T+
Sbjct: 3779 EDYKYSESGIYFAPMADSLQEFKDYIENLPLIDDPEIFGMHENANLVFQYKETSTLINTI 3838

Query: 512  LELQPRDSQARDGAGATREEKVKALLEEILERVTDEFN---------IPELMAKVEERTP 562
            LE+QPR S    G G + +E V+ L+  +  RV ++           + +L  ++   T 
Sbjct: 3839 LEVQPRSSTG--GEGKSNDEIVQELVASVQTRVPEKLEMEGASESLFVKDLQGRLNSLT- 3895

Query: 563  YIVVAFQECGRMNILTREIQRSLRELELGLKGELTMTSHMENLQNALYFDMVPESWARRA 622
               V  QE  R N L + I  SL  L   + G + M+  ME + N+   + VP  W+  A
Sbjct: 3896 --TVLGQEVDRFNNLLKLIHTSLETLNKAIAGFVVMSEEMEKVYNSFLNNQVPALWSNTA 3953

Query: 623  YPSTAGLAAWFPDLLNRIKELEAWTGDFTMPSTVWLTGFFNPQSFLTAIMQSTARKNEWP 682
            YPS   L +W  DL+ R   ++ W      P + W++GFF PQ FLT  +Q+ ARK   P
Sbjct: 3954 YPSLKPLGSWVKDLILRTSFVDLWL-KRGQPKSYWISGFFFPQGFLTGTLQNHARKYNLP 4012

Query: 683  LDQMALQCDMTKKNREEFR--------------------SPPREGAYIHGLFMEGACWDT 722
            +D+++ +  +    R++                        P +G  +HG+FM+ + WD 
Sbjct: 4013 IDELSFKYSVIPTYRDQAAVIEAAKTVQFGQELPMDMELPSPEDGVLVHGMFMDASRWDD 4072

Query: 723  QAGIITEAKLKDLTPPMPVMFIKAIPADKQDCRSVYSCPVYKTSQRGPT---------YV 773
            +  +I +A    + P +PV+  +    + +   ++Y CP+YKT  R  T         +V
Sbjct: 4073 KEMVIEDALPGQMNPVLPVVHFEP-QQNYKPSPTLYHCPLYKTGARAGTLSTTGHSTNFV 4131

Query: 774  WTFNLKTKENPSKWVLAGVALLLQI 798
             T  L +K +   W+  G ALL Q+
Sbjct: 4132 VTVLLPSKRSKDYWIAKGSALLCQL 4156


>gi|223555935 dynein, axonemal, heavy polypeptide 14 isoform 1 [Homo
            sapiens]
          Length = 4515

 Score =  292 bits (748), Expect = 7e-79
 Identities = 252/999 (25%), Positives = 428/999 (42%), Gaps = 217/999 (21%)

Query: 3    DLSKIHPMYQFSLKAFSIVFQKAV-------------ERAAPDES--------------- 34
            DL++I+ MYQFSL  F  VF  +V             E+ +P E                
Sbjct: 3526 DLTQINYMYQFSLDWFHQVFVSSVVSKSKEQEHSFKREKVSPKEVHEFISISKEPNLENE 3585

Query: 35   ---LRERVANLIDSITFSVYQYTIRGLFECDKLTYLAQLTFQILLMNREVNAVELD---- 87
               L + + + ID +T S+++     LF  DKL +  +L   I+  N   N ++ D    
Sbjct: 3586 KNLLDKHIKSAIDMLTKSIFKVVSSALFNEDKLCFSFRLCTVIMQNNANGNLIQDDIGFL 3645

Query: 88   -------FL----------------LRSPVQTGTASPVEFLSHQAWGAVKVLSS-MEEFS 123
                   FL                L S  + G +  +++LS   W   + +S+ +E FS
Sbjct: 3646 PEEEWNIFLYSGILINIKSALSQSRLTSTFEIGESQHLQWLSDSRWRQCQYVSTHLEPFS 3705

Query: 124  NLDRDIEGSAKSWKKFVESEC----------------------PEKEKLPQE-------- 153
             L + +  +   W  F  S+                       PE+ +L  E        
Sbjct: 3706 LLCKSLLSNVSQWDTFKNSKAVYSLISTPFSSENASLEENTKPPEETELLNENKETCNPI 3765

Query: 154  ---WKNKTALQRLCMLRAMRPDRMTYALRDFVEEKLGSKYVVGRALDFATSFEESGPATP 210
               W+  T+ QRL +++ +RP+ +  ++R F+ EK+G+KY+    ++   +++ S   TP
Sbjct: 3766 NFPWEKLTSFQRLILVKVLRPESLNNSVRKFITEKMGNKYLQRTGVNLKDAYKGSNARTP 3825

Query: 211  MFFILSPGVDPLKDVESQGRKLGYTFNNQNFHNVSLGQGQEVVAE-AALDLAAKKGHWVI 269
            +  I + G+D    +    ++L  T ++     +SLG+ Q   AE   L    K   WV 
Sbjct: 3826 LILIQTHGIDLTNILLRFAQELKGTTHHVTI--ISLGRDQAAKAEDLILKALTKTQQWVF 3883

Query: 270  LQNIHLVAKW---LSTLEKKLEEHSENSHPEFRVFMSAEPAPSPEGHIIPQGILENSIKI 326
            LQN HL   +   L T+ +     +    PEFR+++S++   S      P  +L+  +KI
Sbjct: 3884 LQNCHLATSFMPRLCTIVESFNSPNVTIDPEFRLWLSSKSYSS-----FPIPVLKKGLKI 3938

Query: 327  TNEPPTGMHANLHKALD-----NFTQDTLEMCSRETEFKSILFALCYFHAVVAERRKFGP 381
              E P G+ +NL +          T++  E       +K +LF+LC+F+AV+ ER+ +G 
Sbjct: 3939 AVESPQGLKSNLLQTFGCTGSGEVTEEIFENPDCGQWWKKLLFSLCFFNAVINERKNYGI 3998

Query: 382  QGWNRSYPFNTGDLTISVNVLYNFLEANAKVPYDDLRYLFGEIMYGGHITDDWDRRLCRT 441
             GWN +Y FN+ DL +++ VL N L     + +  LRYL GE++YGG + D+WD+R  +T
Sbjct: 3999 LGWNIAYKFNSSDLGVAIKVLENSLRGQPSISWQALRYLIGEVIYGGRVIDNWDKRCLKT 4058

Query: 442  YLGEFIRPEMLEGELSLAPGFPLPGNMDYNGYHQYIDAELPPESPYLYGLHPNAEIGFLT 501
             L +F  PE+L+ + S +       +     Y   I +    + P + G+HP A      
Sbjct: 4059 LLYKFCNPEVLKDDFSFS------RSASIKDYIHIIQSLPDDDLPEVLGIHPEAIRSCWE 4112

Query: 502  QTSEKLFRTVLELQPRDSQAR--DGAGATREEKVKALLEEILERV-----TDEFNI---- 550
               EK    ++ +QP+ + A        +++E V  +L ++L+R+      +E  +    
Sbjct: 4113 TQGEKFIENLIAMQPKTTTANLMIRPEQSKDELVMEILSDLLKRLPLTVEKEEIAVGTPS 4172

Query: 551  -----------PELMAKVEERTPYI---VVAF--QECGRMNILTREIQRSLRELELGLKG 594
                         L   +++  P I   ++ F  QE  R + L   I +SL++L+L +KG
Sbjct: 4173 TLKSMMSSSIWESLSKNLKDHDPLIHCVLLTFLKQEIKRFDKLLFVIHKSLKDLQLAIKG 4232

Query: 595  ELTMTSHMENLQNALYFDMVPESWARRAYPSTAGLAAWFPDLLNRIKELEAWT------- 647
            E+ +T  +E + N+     VP  W + AY S   L++W  DL+ R+     W        
Sbjct: 4233 EIILTQELEEIFNSFLNMRVPTLWQKHAYRSCKPLSSWIDDLIQRLNFFNTWAKVAYTAI 4292

Query: 648  -----------------------------GDF--TMPSTVWLTGFFNPQSFLTAIMQSTA 676
                                          +F    PS  WL  FF PQ+FL A++Q   
Sbjct: 4293 QRRYMRFVTVWKQSIPSTSQKCKHPEDSENNFFEGFPSRYWLPAFFFPQAFLAAVLQDYG 4352

Query: 677  RKNEWPLDQMALQ----CDMTKKN--------------REEFR--SPPREGAYIHGLFME 716
            R     +D +        + T K+              R  F+  +    G YI GLF+E
Sbjct: 4353 RSRGIAVDALTFTHHVISNTTDKDEKFSVFMPKKLNIVRRAFKGSASSHTGVYIFGLFIE 4412

Query: 717  GACWDTQAGIITEAKLKDLTPPMPVMFI-------KAIPADKQDCRSVYS--CPVYKTSQ 767
            GA W+ +  I+ ++   ++    P ++        K   A  Q    +Y+  CPVY+T +
Sbjct: 4413 GARWNREQKILEDSLPLEMCCDFPDIYFLPTKISTKTPNASNQTDSELYAFECPVYQTPE 4472

Query: 768  RG--------PT-YVWTFNLKTKENPSKWVLAGVALLLQ 797
            R         PT ++ +  L TK+ PS W+   VALL +
Sbjct: 4473 RSRILATTGLPTNFLTSVYLSTKKPPSHWITMRVALLCE 4511


>gi|122937398 dynein, cytoplasmic 2, heavy chain 1 [Homo sapiens]
          Length = 4314

 Score =  235 bits (599), Expect = 1e-61
 Identities = 202/827 (24%), Positives = 377/827 (45%), Gaps = 57/827 (6%)

Query: 1    MNDLSKIHPMYQFSLKAFSIVFQKAVERAAPDESLRERVANLIDSITFSVYQYTIRGLFE 60
            ++DLSKI+ MY+FSL AF  +FQ+A++     E+  +R+ +LI S+   VY+Y  R LF+
Sbjct: 3513 ISDLSKINNMYRFSLAAFLRLFQRALQNKQDSENTEQRIQSLISSLQHMVYEYICRCLFK 3572

Query: 61   CDKLTYLAQLT-------FQILLMNREVNAVELDFLLRSPVQTGTAS--PVEFLSHQAWG 111
             D+L +            FQ    +     V  D L ++  Q       P      ++W 
Sbjct: 3573 ADQLMFALHFVRGMHPELFQENEWDTFTGVVVGDMLRKADSQQKIRDQLPSWIDQERSWA 3632

Query: 112  AVKVLSSMEE-FSNLDRDIEGSAKSWKKFVESECPEKEKLPQEWKNKTALQRLCMLRAMR 170
               +  ++   +  L  +    A  W+ +  +   E+E      K  +  Q++ +++A+R
Sbjct: 3633 VATLKIALPSLYQTLCFE---DAALWRTYYNNSMCEQEFPSILAKKVSLFQQILVVQALR 3689

Query: 171  PDRMTYALRDFVEEKLGSKYVVGRALDFATSFEESGPATPMFFILSPGVDPLKDVESQGR 230
            PDR+  A+  F  + LG K V    L+    ++E+    P+  I+SPG DP ++++    
Sbjct: 3690 PDRLQSAMALFACKTLGLKEVSPLPLNLKRLYKETLEIEPILIIISPGADPSQELQELAN 3749

Query: 231  KLGYTFNNQNFHNVSLGQGQEVVAEAALDLAAKKGHWVILQNIHLVAKWLSTLEKKLEEH 290
                  + + +H V++GQGQ  +A   L   A+ G W+ L+N+HLV  WL  LEK+L  +
Sbjct: 3750 A---ERSGECYHQVAMGQGQADLAIQMLKECARNGDWLCLKNLHLVVSWLPVLEKEL--N 3804

Query: 291  SENSHPEFRVFMSAEPAPSPEGHIIPQGILENSIKITNEPPTGMHANLHKALDNFTQDTL 350
            +      FR++++AE  P+         +L++S+KIT E P G+  NL +  +++T + +
Sbjct: 3805 TLQPKDTFRLWLTAEVHPN-----FTPILLQSSLKITYESPPGLKKNLMRTYESWTPEQI 3859

Query: 351  EMCSRETEFKSILFALCYFHAVVAERRKFGPQGWNRSYPFNTGDLTISVNVLYNFLEANA 410
                  T     LF+L +FHA   ERR + PQGW + Y F+  DL    N++    +   
Sbjct: 3860 SK-KDNTHRAHALFSLAWFHAACQERRNYIPQGWTKFYEFSLSDLRAGYNIIDRLFDGAK 3918

Query: 411  KVPYDDLRYLFGEIMYGGHITDDWDRRLCRTYLGEFIRPEMLE-----GELSLAP-GFPL 464
             V ++ +  L    +YGG I + +D R+ ++YL +F    +++      + S+ P    L
Sbjct: 3919 DVQWEFVHGLLENAIYGGRIDNYFDLRVLQSYLKQFFNSSVIDVFNQRNKKSIFPYSVSL 3978

Query: 465  PGNMDYNGYHQYIDAELPPESPYLYGLHPNAEIGFLTQTSEKLFRTVLELQPRDSQARDG 524
            P +     Y   I+     + P  +GL  N     + ++S+++  + +  Q R       
Sbjct: 3979 PQSCSILDYRAVIEKIPEDDKPSFFGLPAN-----IARSSQRMISSQVISQLRILGRSIT 4033

Query: 525  AGATREEKV----KALLEEILERVTDEFN-IPELMAKVEERTPYIVVAFQECGRMNI--L 577
            AG+  + ++     + +  + +++    N I + +    +R    +++F    + N   L
Sbjct: 4034 AGSKFDREIWSNELSPVLNLWKKLNQNSNLIHQKVPPPNDRQGSPILSFIILEQFNAIRL 4093

Query: 578  TREIQRSLRELELGLKGELTMTSHMENLQNALYFDMVPESWARRAYPSTAGLAAWFPDLL 637
             + + +SL  L   ++G   ++S ++ L +AL     P +W  + +        +   L+
Sbjct: 4094 VQSVHQSLAALSKVIRGTTLLSSEVQKLASALLNQKCPLAWQSK-WEGPEDPLQYLRGLV 4152

Query: 638  NRIKELEAWTG----DFTMPSTVWLTGFFNPQSFLTAIMQSTARKNEWPLDQMALQCDMT 693
             R   ++ W         +  T+ L+  F+P +FL A+ Q TAR     +D +       
Sbjct: 4153 ARALAIQNWVDKAEKQALLSETLDLSELFHPDTFLNALRQETARAVGRSVDSLKFVASWK 4212

Query: 694  KKNREEFRSPPREGAYIHGLFMEGACWDTQAGIITEAKLKDLTPPMPVMFIKAIPADKQD 753
             + +E      +    I GL +EG  +D       +     ++  +P  F+  IP D   
Sbjct: 4213 GRLQE-----AKLQIKISGLLLEGCSFDGNQLSENQLDSPSVSSVLP-CFMGWIPQDACG 4266

Query: 754  CRSVYSC---PVYKTSQRGPTYVWTFNLKTKENPSKWVLAGVALLLQ 797
              S   C   PVY +++R    V   ++    N  +W+  G AL L+
Sbjct: 4267 PYSPDECISLPVYTSAER-DRVVTNIDVPCGGNQDQWIQCGAALFLK 4312


>gi|33350932 cytoplasmic dynein 1 heavy chain 1 [Homo sapiens]
          Length = 4646

 Score =  229 bits (584), Expect = 8e-60
 Identities = 209/856 (24%), Positives = 382/856 (44%), Gaps = 88/856 (10%)

Query: 1    MNDLSKIHPMYQFSLKAF-----SIVFQKAVERAAPDESLRERVANLIDSITFSV-YQYT 54
            M  L +IH +YQ+SL+ F     +++++    +   D + R    ++I    F V +   
Sbjct: 3815 MESLKQIHFLYQYSLQFFLDIYHNVLYENPNLKGVTDHTQR---LSIITKDLFQVAFNRV 3871

Query: 55   IRGLFECDKLTYLAQLTFQILL---MNREVNAVELDFLLRSP---VQTGTASPVEFLSHQ 108
             RG+   D +T+ A L  +I L   +       E    LR     +  G+   ++ L+ +
Sbjct: 3872 ARGMLHQDHITF-AMLLARIKLKGTVGEPTYDAEFQHFLRGNEIVLSAGSTPRIQGLTVE 3930

Query: 109  AWGAVKVLSSMEEFSNLDRDIEGSAKSWKKFVESECPEKEKLPQEWKNKT-------ALQ 161
               AV  LS +  F +L   ++   + +  +++S  PE + +P  W  +T       A+ 
Sbjct: 3931 QAEAVVRLSCLPAFKDLIAKVQAD-EQFGIWLDSSSPE-QTVPYLWSEETPATPIGQAIH 3988

Query: 162  RLCMLRAMRPDRMTYALRDFVEEKLGSKY--VVGRALDFATSF-EESGPATPMFFILSPG 218
            RL +++A RPDR+      FV   LG  +  ++ + LD       E  P TP+     PG
Sbjct: 3989 RLLLIQAFRPDRLLAMAHMFVSTNLGESFMSIMEQPLDLTHIVGTEVKPNTPVLMCSVPG 4048

Query: 219  VDPLKDVESQGRKLGYTFNNQNFHNVSLGQGQEV-VAEAALDLAAKKGHWVILQNIHLVA 277
             D    VE    +      N    ++++G  +    A+ A++ A K G WV+L+N+HL  
Sbjct: 4049 YDASGHVEDLAAE-----QNTQITSIAIGSAEGFNQADKAINTAVKSGRWVMLKNVHLAP 4103

Query: 278  KWLSTLEKKLEEHSENSHPEFRVFMSAEPAPSPEGHIIPQGILENSIKITNEPPTGMHAN 337
             WL  LEKKL  HS   H  FR+F++ E  P      +P  +L        EPP G+ AN
Sbjct: 4104 GWLMQLEKKL--HSLQPHACFRLFLTMEINPK-----VPVNLLRAGRIFVFEPPPGVKAN 4156

Query: 338  LHKALDNFTQDTLEMCSRETEFKSILFALCYFHAVVAERRKFGPQGWNRSYPFNTGDLTI 397
            + +   +     +  C    E   + F L +FHA++ ER ++ P GW++ Y F   DL  
Sbjct: 4157 MLRTFSSIPVSRI--CKSPNERARLYFLLAWFHAIIQERLRYAPLGWSKKYEFGESDLRS 4214

Query: 398  SVNVLYNFLEANA---------KVPYDDLRYLFGEIMYGGHITDDWDRRLCRTYLGEFIR 448
            + + +  +L+  A         K+P+  L+ L  + +YGG + +++D+RL  T+L     
Sbjct: 4215 ACDTVDTWLDDTAKGRQNISPDKIPWSALKTLMAQSIYGGRVDNEFDQRLLNTFLERLFT 4274

Query: 449  PEMLEGELSLA------PGFPLPGNMDYNGYHQYIDAELPPESPYLYGLHPNAEIGFLTQ 502
                + E  LA          +P  +    + Q+++     ++P   GL  NAE   LT 
Sbjct: 4275 TRSFDSEFKLACKVDGHKDIQMPDGIRREEFVQWVELLPDTQTPSWLGLPNNAERVLLTT 4334

Query: 503  TSEKLFRTVLELQPRDSQARDGAGATREEKVK---------ALLEEILERVTDEFN-IPE 552
                +   +L++Q  + +  D A A  E+K +         A +  +    ++  + IP+
Sbjct: 4335 QGVDMISKMLKMQMLEDE-DDLAYAETEKKTRTDSTSDGRPAWMRTLHTTASNWLHLIPQ 4393

Query: 553  LMAKVEE-----RTPYIVVAFQECGRMNILTREIQRSLRELELGLKGELTMTSHMENLQN 607
             ++ ++      + P      +E      L +++++ L ++    +G+   T+++  L N
Sbjct: 4394 TLSHLKRTVENIKDPLFRFFEREVKMGAKLLQDVRQDLADVVQVCEGKKKQTNYLRTLIN 4453

Query: 608  ALYFDMVPESWARRAYPSTAGLAAWFPDLLNRIKELE------AWTGDFTMPST-VWLTG 660
             L   ++P SW+    P+   +  W  D   RIK+L+      A  G   + +  V L G
Sbjct: 4454 ELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIKQLQNISLAAASGGAKELKNIHVCLGG 4513

Query: 661  FFNPQSFLTAIMQSTARKNEWPLDQMALQCDMTKKNREEFRSPPREGAYIHGLFMEGACW 720
             F P++++TA  Q  A+ N W L+++ L+ ++T        +       + GL ++GA  
Sbjct: 4514 LFVPEAYITATRQYVAQANSWSLEELCLEVNVTTSQGATLDAC---SFGVTGLKLQGATC 4570

Query: 721  DTQAGIITEAKLKDLTPPMPVMFIKAIPADKQDCRSVYSCPVYKTSQRGP-TYVWTFNLK 779
            +     ++ A +    P   + ++K    +K+   SV + PVY    R    +   F + 
Sbjct: 4571 NNNKLSLSNA-ISTALPLTQLRWVKQTNTEKK--ASVVTLPVYLNFTRADLIFTVDFEIA 4627

Query: 780  TKENPSKWVLAGVALL 795
            TKE+P  +   GVA+L
Sbjct: 4628 TKEDPRSFYERGVAVL 4643


>gi|222144249 dynein heavy chain domain 1 isoform 1 [Homo sapiens]
          Length = 4753

 Score = 87.0 bits (214), Expect = 6e-17
 Identities = 186/886 (20%), Positives = 322/886 (36%), Gaps = 132/886 (14%)

Query: 1    MNDLSKIHPMYQFSLKAFSIVFQKAVERAAP-----DESLRERVANLIDSITFSVYQYTI 55
            ++ L  + P++  S + +  V ++A++   P      E L   +  L   +T  +   T+
Sbjct: 3864 LSQLQNLLPLFCMSPENWLAVTKQALDSMKPREINHGEDLASHLLQLRAHLTRQLLGSTV 3923

Query: 56   R--GLFECDKLTYLAQLTFQILLMNREVNAVELDFLLRSPVQTGTASPVE---------- 103
               GL +   +  L  L     L+     A EL+ L   P    + S V           
Sbjct: 3924 TALGLTQVPLVGALGALA----LLQATGKASELERLALWPGLAASPSTVHSKPVSDVARP 3979

Query: 104  -FLSHQAWGAVKVLSSMEEFSNLDRDIEGSAKSWKKFVESECPEKEKLPQEWKNKTAL-Q 161
             +L  +AW   ++L  +  F  L   + G + +W+ ++          P       +L Q
Sbjct: 3980 AWLGPKAWHECEMLELLPPFVGLCASLAGHSSAWQAYLSLSSTVLGPAPGPGPEPLSLLQ 4039

Query: 162  RLCMLRAMRPDRMTYALRDFVEEKLGSKYVVGRALDFAT-----SFEESGPATPMFFILS 216
            +L + R +RP+ +  AL DF    LG      R LD  T      F+ S    PM  +L 
Sbjct: 4040 KLILWRVLRPECLAGALADFTTSLLG------RPLDENTYAPTMPFKHSQATQPMLILLP 4093

Query: 217  PG------VDPLKDVESQGRKLGYTFNNQNFHNVSLGQ---GQEVVAEAALDLAAKKGHW 267
            P       + PL  ++    K  Y    +    ++LG        V  + L  A  +GHW
Sbjct: 4094 PPGHPSATLHPLTVIQKLAAK--YQQGQKQLQVIALGSEAWDPVSVVVSTLSQAMYEGHW 4151

Query: 268  VILQNIHLVAKWLSTL-------------------EKKLEEHSENS----HPEFRVFMSA 304
            ++L N HL+  W   L                   E+ L++    +    H +FR+++  
Sbjct: 4152 LVLDNCHLMPHWPKELLQLLLELLGRAKVVADLESEQLLDQPESRNVSTVHRDFRLWLIV 4211

Query: 305  EPAPSPEGHIIPQGILENSIKITNEPPTGMHANLHKALDNFTQDTLEMCSRETEFKSILF 364
               P+     +P  + ++S+ +          N    L +   D++E+  +    +    
Sbjct: 4212 ---PAESSASLPAVLTQHSMPV--------FWNQSLELGHVLIDSVELAQQVLYMQPPTQ 4260

Query: 365  AL--CYFHAVVAERRKFGPQGWNRSYPFNTGDLTISVNVLYNFLEANAKVPYDDLRYLFG 422
            AL     H ++  R+ +G +       ++   LT  V    + L A+   P   ++ L  
Sbjct: 4261 ALPLLLLHGLLLHRQLYGTRLQAHRGRWSQVTLT-QVLQTQDQLWASLSNPRAAMQELAA 4319

Query: 423  EIMYGGHITDDWDRR----LCRTYL----GEFIRPEMLEGELSLAPGFPLPGNMDYNGYH 474
             + YGG + D  DR     L +  L    G +++P   +  L+     P    +D     
Sbjct: 4320 SVFYGGPLGDTEDREALISLTQACLSPSSGSWVQPHTPQSLLATLMPLPELRELDAMAEC 4379

Query: 475  QYIDAELP-PESPYLYGLHPNAEIGFLTQTSEKLFRTVLELQP-------RDSQARDGAG 526
            +     LP P  P L GL    +   L + S  L   +    P       R +Q  +   
Sbjct: 4380 KAQMHLLPSPPEPRLCGLSEGPQAWLLRRQSRALLSALQRSSPVWVPESRRGAQLAERRL 4439

Query: 527  ATREEKVKALLEEILERVT-----DEFNIPELMAKVEERTPYIVVAFQECGRMNILTREI 581
              R  +V   LE + + +T     DE + P  +     R P   V   E   ++ L   +
Sbjct: 4440 RQRLVQVNRRLESLQDLLTHVIRQDESDAPWSVLGPNARRPLEGVLETEALELSQLVGTL 4499

Query: 582  QRSLRELELGLKGELTMTSHM-ENLQNALYFDMVPESWARRAYPSTAGLAAWFPDLLNRI 640
            QR L  L   LKG     S     + +AL+   +P  W   A         W   L  R 
Sbjct: 4500 QRDLDCLLQQLKGAPPCPSRRCAAVAHALWTGRLPLPWRPHAPAGPQPPWHWLRQLSRRG 4559

Query: 641  KELEAWTG-----DFTMPSTVW-LTGFFNPQSFLTAI-----MQSTARKNEWPLDQMALQ 689
            + L  + G        +P  V+ L+ F +P+  L A+     +      + +P  + ++ 
Sbjct: 4560 QLLVRYLGVGADASSDVPERVFHLSAFRHPRRLLLALRGEAALDQNVPSSNFPGSRGSVS 4619

Query: 690  CDMTKKNREEFRSP-------------PREGAYIHGLFMEGACWDTQAGIITEAKLKDLT 736
              +  K  E   +P             P  G  + GL +  A WD  AG + ++     +
Sbjct: 4620 SQLQYKRLEMNSNPLHFRVENGPNPTVPERGLLLIGLQVLHAEWDPIAGALQDSPSSQPS 4679

Query: 737  PPMPVMFIKAIPADKQ----DCRSVYSCPVYKTSQRGPTYVWTFNL 778
            P  PV      P           +VYSCPVY     G   + + N+
Sbjct: 4680 PLPPVSISTQAPGTSDLPAPADLTVYSCPVYMGGPLGTAKLQSRNI 4725


>gi|24415404 MDN1, midasin homolog [Homo sapiens]
          Length = 5596

 Score = 37.4 bits (85), Expect = 0.055
 Identities = 25/79 (31%), Positives = 32/79 (40%), Gaps = 14/79 (17%)

Query: 255 EAALDLAAKKGHWVILQNIHLVAKWLSTLEKKLEEHSENS--------------HPEFRV 300
           E  L  A KKG W++L  I+L A  +      L E S  S              HP+FR+
Sbjct: 820 EGTLAQAVKKGEWILLDEINLAAPEILECLSGLLEGSSGSLVLLDRGDTEPLVRHPDFRL 879

Query: 301 FMSAEPAPSPEGHIIPQGI 319
           F    PA       +P GI
Sbjct: 880 FACMNPATDVGKRNLPPGI 898



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 20/69 (28%), Positives = 33/69 (47%), Gaps = 11/69 (15%)

Query: 249  GQEVVAEAALDLAAKKGHWVILQNIHLV-AKWLSTLEKKLEEHSE----------NSHPE 297
            G+ V  E  L  A +KG+W+IL  ++L     L  L + L+++ E           +HP 
Sbjct: 1129 GKLVFKEGVLIDAMRKGYWIILDELNLAPTDVLEALNRLLDDNRELLVTETQEVVKAHPR 1188

Query: 298  FRVFMSAEP 306
            F +F +  P
Sbjct: 1189 FMLFATQNP 1197


>gi|110618244 retinoblastoma binding protein 2 isoform 1 [Homo
            sapiens]
          Length = 1690

 Score = 34.3 bits (77), Expect = 0.47
 Identities = 29/95 (30%), Positives = 45/95 (47%), Gaps = 8/95 (8%)

Query: 514  LQPRDSQARDGAGATREEKVKALLEEILERVTDEFNIPELMAKVEER--TPYIVVAFQEC 571
            L PR      G+G  R +KVK L+E+  E+  D   + +L   +EE   T  +V  F+E 
Sbjct: 1074 LSPRTDIGVYGSGKNRRKKVKELIEKEKEKDLDLEPLSDLEEGLEETRDTAMVVAVFKER 1133

Query: 572  GRMNILTREIQRSLRELELGLKGELTMTSHMENLQ 606
             +  I   E   SLR   L    ++TM   +E ++
Sbjct: 1134 EQKEI---EAMHSLRAANL---AKMTMVDRIEEVK 1162


>gi|110618242 retinoblastoma binding protein 2 isoform 2 [Homo
            sapiens]
          Length = 1641

 Score = 34.3 bits (77), Expect = 0.47
 Identities = 29/95 (30%), Positives = 45/95 (47%), Gaps = 8/95 (8%)

Query: 514  LQPRDSQARDGAGATREEKVKALLEEILERVTDEFNIPELMAKVEER--TPYIVVAFQEC 571
            L PR      G+G  R +KVK L+E+  E+  D   + +L   +EE   T  +V  F+E 
Sbjct: 1074 LSPRTDIGVYGSGKNRRKKVKELIEKEKEKDLDLEPLSDLEEGLEETRDTAMVVAVFKER 1133

Query: 572  GRMNILTREIQRSLRELELGLKGELTMTSHMENLQ 606
             +  I   E   SLR   L    ++TM   +E ++
Sbjct: 1134 EQKEI---EAMHSLRAANL---AKMTMVDRIEEVK 1162


>gi|119703749 hydrocephalus inducing isoform a [Homo sapiens]
          Length = 5120

 Score = 33.9 bits (76), Expect = 0.61
 Identities = 33/139 (23%), Positives = 56/139 (40%), Gaps = 9/139 (6%)

Query: 195  ALDFATSFEESGPATPMFFILSPGVDPLKDVESQGRKLGYTFNNQNFHNVSLGQGQ-EVV 253
            ++ F+T       A P  F++    +     E Q  K G TF     HN  LG  Q E+ 
Sbjct: 4860 SVTFSTECRMPDIALPSQFVVPANSEGTFSFEFQPLKAGETFGRLTLHNTDLGYYQYELY 4919

Query: 254  AEAALDLAAKKGHW--VILQNIHLVAKWLSTLEKKLEEHSENSHPEFRVFMSAEPAPSPE 311
             +A   L  K  H+  V+  +  ++ K+++   ++ E +      +F        AP   
Sbjct: 4920 LKATPALPEKPVHFQTVLGSSQIILVKFINYTRQRTEYYCRTDCTDFHAEKLINAAPG-- 4977

Query: 312  GHIIPQGILENSIKITNEP 330
                 QG  E S+++  EP
Sbjct: 4978 ----GQGGTEASVEVLFEP 4992


>gi|167860120 phospholipase A2, group IVB [Homo sapiens]
          Length = 781

 Score = 32.7 bits (73), Expect = 1.4
 Identities = 28/87 (32%), Positives = 40/87 (45%), Gaps = 3/87 (3%)

Query: 215 LSPGVDPLKDVE-SQGRKLGYTFNNQNFHNVSLGQGQEVVAEAALDLAAKKGHWVILQNI 273
           L  G DP+  V    G      F  ++F     G+G+  V E  L   A +G W++   +
Sbjct: 85  LVTGDDPVLSVLFDAGTLRAGEFRRESFSLSPQGEGRLEV-EFRLQSLADRGEWLVSNGV 143

Query: 274 HLVAKWLSTLEKKLEEHSENSHPEFRV 300
            LVA+ LS L  +LEE  +    E RV
Sbjct: 144 -LVARELSCLHVQLEETGDQKSSEHRV 169


>gi|4826914 JMJD7-PLA2G4B protein [Homo sapiens]
          Length = 1012

 Score = 32.7 bits (73), Expect = 1.4
 Identities = 28/87 (32%), Positives = 40/87 (45%), Gaps = 3/87 (3%)

Query: 215 LSPGVDPLKDVE-SQGRKLGYTFNNQNFHNVSLGQGQEVVAEAALDLAAKKGHWVILQNI 273
           L  G DP+  V    G      F  ++F     G+G+  V E  L   A +G W++   +
Sbjct: 316 LVTGDDPVLSVLFDAGTLRAGEFRRESFSLSPQGEGRLEV-EFRLQSLADRGEWLVSNGV 374

Query: 274 HLVAKWLSTLEKKLEEHSENSHPEFRV 300
            LVA+ LS L  +LEE  +    E RV
Sbjct: 375 -LVARELSCLHVQLEETGDQKSSEHRV 400


>gi|118918407 spectrin repeat containing, nuclear envelope 2 isoform 5
            [Homo sapiens]
          Length = 6907

 Score = 32.3 bits (72), Expect = 1.8
 Identities = 29/116 (25%), Positives = 54/116 (46%), Gaps = 11/116 (9%)

Query: 531  EKVKALLEEILERVTDEFNIPELMAKVEERTPYIVVAFQEC----GRMNILTREIQRSLR 586
            EK + LL  +L+R+    N+PE    VE      V AFQE      R N L +++Q++  
Sbjct: 3522 EKQQLLLTLLLQRIRSIQNVPESSGAVE-----TVPAFQEITSMKERCNKLLQKVQKNKE 3576

Query: 587  ELELGLKGELTMTSHMENLQNALYFDMVPESWARRAYPSTAGLAAWFPDLLNRIKE 642
             ++  ++   + T  +  L+N  +F     S+   A+      +  F +L + +K+
Sbjct: 3577 LVQTEIQERHSFTKEIIALKN--FFQQTTTSFQNMAFQDHPEKSEQFEELQSILKK 3630


>gi|118918403 spectrin repeat containing, nuclear envelope 2 isoform 1
            [Homo sapiens]
          Length = 6885

 Score = 32.3 bits (72), Expect = 1.8
 Identities = 29/116 (25%), Positives = 54/116 (46%), Gaps = 11/116 (9%)

Query: 531  EKVKALLEEILERVTDEFNIPELMAKVEERTPYIVVAFQEC----GRMNILTREIQRSLR 586
            EK + LL  +L+R+    N+PE    VE      V AFQE      R N L +++Q++  
Sbjct: 3522 EKQQLLLTLLLQRIRSIQNVPESSGAVE-----TVPAFQEITSMKERCNKLLQKVQKNKE 3576

Query: 587  ELELGLKGELTMTSHMENLQNALYFDMVPESWARRAYPSTAGLAAWFPDLLNRIKE 642
             ++  ++   + T  +  L+N  +F     S+   A+      +  F +L + +K+
Sbjct: 3577 LVQTEIQERHSFTKEIIALKN--FFQQTTTSFQNMAFQDHPEKSEQFEELQSILKK 3630


>gi|4758528 hepatocyte growth factor-regulated tyrosine kinase
           substrate [Homo sapiens]
          Length = 777

 Score = 32.0 bits (71), Expect = 2.3
 Identities = 21/54 (38%), Positives = 30/54 (55%), Gaps = 5/54 (9%)

Query: 284 EKKLEEHSENSHPEFRVFMSAEPAPSP-EGHIIPQGILENSIKITNE---PPTG 333
           EKK EE  ++  P   V ++ EPA  P EGH  P  ++EN +  T+    PP+G
Sbjct: 336 EKKQEEARKSPTPSAPVPLT-EPAAQPGEGHAAPTNVVENPLPETDSQPIPPSG 388


>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
          Length = 1139

 Score = 31.6 bits (70), Expect = 3.0
 Identities = 31/107 (28%), Positives = 49/107 (45%), Gaps = 16/107 (14%)

Query: 494 NAEIGFLTQTSEKLFRTVLELQPRDSQARDGAGATREEKVKAL-LEEILERVTDE-FNIP 551
           N E+  + Q  E+L       Q   SQA       +E+   AL  EE++E +TD   N+ 
Sbjct: 265 NQELEVVRQQRERL-------QEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLE 317

Query: 552 ELMAKVEERTPYIVVAFQECGRMNILTREIQRSLRELELGLKGELTM 598
           E + ++ E          +   MN +  E+Q + RE EL L+ +L M
Sbjct: 318 EKVRELRETVG-------DLEAMNEMNDELQENARETELELREQLDM 357


>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
          Length = 1253

 Score = 31.6 bits (70), Expect = 3.0
 Identities = 31/107 (28%), Positives = 49/107 (45%), Gaps = 16/107 (14%)

Query: 494 NAEIGFLTQTSEKLFRTVLELQPRDSQARDGAGATREEKVKAL-LEEILERVTDE-FNIP 551
           N E+  + Q  E+L       Q   SQA       +E+   AL  EE++E +TD   N+ 
Sbjct: 379 NQELEVVRQQRERL-------QEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLE 431

Query: 552 ELMAKVEERTPYIVVAFQECGRMNILTREIQRSLRELELGLKGELTM 598
           E + ++ E          +   MN +  E+Q + RE EL L+ +L M
Sbjct: 432 EKVRELRETVG-------DLEAMNEMNDELQENARETELELREQLDM 471


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,314,693
Number of Sequences: 37866
Number of extensions: 1444077
Number of successful extensions: 3642
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 3465
Number of HSP's gapped (non-prelim): 75
length of query: 798
length of database: 18,247,518
effective HSP length: 110
effective length of query: 688
effective length of database: 14,082,258
effective search space: 9688593504
effective search space used: 9688593504
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.