Guide to the Human Genome
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Search of human proteins with 22027634

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo
sapiens]
         (773 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo sapiens]     1613   0.0  
gi|22027632 diacylglycerol kinase, beta isoform 1 [Homo sapiens]     1607   0.0  
gi|124256476 diacylglycerol kinase gamma isoform 1 [Homo sapiens]     976   0.0  
gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo sapiens]     927   0.0  
gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens]         850   0.0  
gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens]         850   0.0  
gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens]         850   0.0  
gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens]         850   0.0  
gi|124256482 diacylglycerol kinase gamma isoform 3 [Homo sapiens]     823   0.0  
gi|4758156 diacylglycerol kinase, iota [Homo sapiens]                 293   3e-79
gi|41872507 diacylglycerol kinase zeta isoform 2 [Homo sapiens]       285   9e-77
gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens]       285   9e-77
gi|157688564 diacylglycerol kinase zeta isoform 4 [Homo sapiens]      285   1e-76
gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens]       285   1e-76
gi|4503313 diacylglycerol kinase epsilon [Homo sapiens]               273   6e-73
gi|40806175 diacylglycerol kinase, theta [Homo sapiens]               254   3e-67
gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo ...   210   5e-54
gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo ...   210   5e-54
gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens]       207   4e-53
gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens]       207   4e-53
gi|62000702 diacylglycerol kinase kappa [Homo sapiens]                183   6e-46
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]            62   3e-09
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]            62   3e-09
gi|13384594 protein kinase C, gamma [Homo sapiens]                     61   3e-09
gi|47157325 protein kinase C, delta [Homo sapiens]                     61   5e-09
gi|31377782 protein kinase C, delta [Homo sapiens]                     61   5e-09
gi|4506067 protein kinase C, alpha [Homo sapiens]                      59   1e-08
gi|4885563 protein kinase C, epsilon [Homo sapiens]                    58   3e-08
gi|40254415 guanylate cyclase activator 1A (retina) [Homo sapiens]     58   3e-08
gi|19913446 hippocalcin [Homo sapiens]                                 58   3e-08

>gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo sapiens]
          Length = 773

 Score = 1613 bits (4177), Expect = 0.0
 Identities = 773/773 (100%), Positives = 773/773 (100%)

Query: 1   MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDF 60
           MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDF
Sbjct: 1   MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDF 60

Query: 61  EGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPR 120
           EGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPR
Sbjct: 61  EGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPR 120

Query: 121 TTSPANTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQ 180
           TTSPANTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQ
Sbjct: 121 TTSPANTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQ 180

Query: 181 MMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVK 240
           MMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVK
Sbjct: 181 MMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVK 240

Query: 241 DDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVK 300
           DDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVK
Sbjct: 241 DDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVK 300

Query: 301 SKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDC 360
           SKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDC
Sbjct: 301 SKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDC 360

Query: 361 GPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANS 420
           GPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANS
Sbjct: 361 GPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANS 420

Query: 421 VTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGL 480
           VTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGL
Sbjct: 421 VTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGL 480

Query: 481 NFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYE 540
           NFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYE
Sbjct: 481 NFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYE 540

Query: 541 GENLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFH 600
           GENLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFH
Sbjct: 541 GENLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFH 600

Query: 601 IMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIA 660
           IMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIA
Sbjct: 601 IMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIA 660

Query: 661 ILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGL 720
           ILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGL
Sbjct: 661 ILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGL 720

Query: 721 EGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTVSTE 773
           EGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTVSTE
Sbjct: 721 EGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTVSTE 773


>gi|22027632 diacylglycerol kinase, beta isoform 1 [Homo sapiens]
          Length = 804

 Score = 1607 bits (4162), Expect = 0.0
 Identities = 769/770 (99%), Positives = 770/770 (100%)

Query: 1   MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDF 60
           MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDF
Sbjct: 1   MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDF 60

Query: 61  EGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPR 120
           EGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPR
Sbjct: 61  EGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPR 120

Query: 121 TTSPANTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQ 180
           TTSPANTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQ
Sbjct: 121 TTSPANTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQ 180

Query: 181 MMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVK 240
           MMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVK
Sbjct: 181 MMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVK 240

Query: 241 DDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVK 300
           DDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVK
Sbjct: 241 DDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVK 300

Query: 301 SKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDC 360
           SKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDC
Sbjct: 301 SKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDC 360

Query: 361 GPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANS 420
           GPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANS
Sbjct: 361 GPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANS 420

Query: 421 VTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGL 480
           VTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGL
Sbjct: 421 VTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGL 480

Query: 481 NFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYE 540
           NFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYE
Sbjct: 481 NFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYE 540

Query: 541 GENLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFH 600
           GENLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFH
Sbjct: 541 GENLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFH 600

Query: 601 IMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIA 660
           IMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIA
Sbjct: 601 IMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIA 660

Query: 661 ILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGL 720
           ILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGL
Sbjct: 661 ILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGL 720

Query: 721 EGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTV 770
           EGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCT+
Sbjct: 721 EGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTI 770


>gi|124256476 diacylglycerol kinase gamma isoform 1 [Homo sapiens]
          Length = 791

 Score =  976 bits (2524), Expect = 0.0
 Identities = 474/802 (59%), Positives = 575/802 (71%), Gaps = 79/802 (9%)

Query: 4   QEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGF 63
           +E+W  L+P EF QLQKY+EYS+KK+KD L EF+  G L +Y+P       ++ I ++ F
Sbjct: 3   EERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDP-------HEPISYDVF 55

Query: 64  KLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTS 123
           KLFM+ +LE +LP   + HLF++FS K  H +    ++ A  S     +         T 
Sbjct: 56  KLFMRAYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATK 115

Query: 124 PANTCSPE----------------------------------VIHLKDIVCYLSLLERGR 149
               C+P+                                  V++LKD+VCYLSLLE GR
Sbjct: 116 ADEACAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGR 175

Query: 150 PEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYLEWDVTELNPILHEMMEEIDYD 209
           P+DKLEFMFRLYD+D NG LD +E++ I++QM+H+A+YLEWD TEL PIL EM++ +DYD
Sbjct: 176 PQDKLEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYD 235

Query: 210 HDGTVSLEEWIQGGMTTIPLLVLLGLENN-VKDDGQHVWRLKHFNKPAYCNLCLNMLIGV 268
            DG VSL+EW+ GGMTTIPLLVLLG++++  K DG+H W +KHF KP YCN C  ML+GV
Sbjct: 236 RDGFVSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGV 295

Query: 269 GKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVMHHYWVEGNCPTKCDKCHKTV 328
            KQGLCC++CKYTVHERCV+R  P C+KTY K+KR+ +VM H WVEGN   KCD+CHK++
Sbjct: 296 RKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSI 355

Query: 329 KCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSV 388
           KCYQ +T  HCVWC++T H KC   L   CD G L+DHIL PT+ICP+            
Sbjct: 356 KCYQSVTARHCVWCRMTFHRKC--ELSTLCDGGELRDHILLPTSICPIT----------- 402

Query: 389 PEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSG 448
                    +++ G +    V  K ++             ++ P PGTHPLLV VNPKSG
Sbjct: 403 ---------RDRPGEKSDGCVSAKGELVMQ---------YKIIPTPGTHPLLVLVNPKSG 444

Query: 449 GKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIE 508
           G+QGERI RKF YLLNP+QV++L   GP PGLNFFRD PDFRVLACGGDGTVGW+LDCI+
Sbjct: 445 GRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDFRVLACGGDGTVGWILDCID 504

Query: 509 KANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIP 568
           KAN  KHPPVA+LPLGTGNDLARCLRWGGGYEG +L KILKDIE S  +MLDRW  EVIP
Sbjct: 505 KANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIP 564

Query: 569 NDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSET 628
            ++ E GD VPYSI+NNYFSIGVDASIAHRFH+MREKHPEKFNSRMKNK WYFEFGTSET
Sbjct: 565 REEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSET 624

Query: 629 FSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEK 688
           F+ATCKKLH+ +E+ECDGV +DL NI LEGIAILNIPSM+GG+NLWGE+KK R+  R  +
Sbjct: 625 FAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESR 684

Query: 689 KGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVI 748
           KG      VTD KELKF  QDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQC+ V I
Sbjct: 685 KG------VTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTI 738

Query: 749 RTSKSLPMQIDGEPWMQTPCTV 770
           RT+K LPMQ+DGEPWMQ  CT+
Sbjct: 739 RTNKLLPMQVDGEPWMQPCCTI 760


>gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo sapiens]
          Length = 766

 Score =  927 bits (2397), Expect = 0.0
 Identities = 458/802 (57%), Positives = 556/802 (69%), Gaps = 104/802 (12%)

Query: 4   QEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGF 63
           +E+W  L+P EF QLQKY+EYS+KK+KD L EF+  G L +Y+P       ++ I ++ F
Sbjct: 3   EERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDP-------HEPISYDVF 55

Query: 64  KLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTS 123
           KLFM+ +LE +LP   + HLF++FS K  H +    ++ A  S     +         T 
Sbjct: 56  KLFMRAYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATK 115

Query: 124 PANTCSPE----------------------------------VIHLKDIVCYLSLLERGR 149
               C+P+                                  V++LKD+VCYLSLLE GR
Sbjct: 116 ADEACAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGR 175

Query: 150 PEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYLEWDVTELNPILHEMMEEIDYD 209
           P+DKLEFMFRLYD+D NG LD +E++ I++QM+H+A+YLEWD TEL PIL EM++ +DYD
Sbjct: 176 PQDKLEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYD 235

Query: 210 HDGTVSLEEWIQGGMTTIPLLVLLGLENN-VKDDGQHVWRLKHFNKPAYCNLCLNMLIGV 268
            DG VSL+EW+ GGMTTIPLLVLLG++++  K DG+H W +KHF KP YCN C  ML+GV
Sbjct: 236 RDGFVSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGV 295

Query: 269 GKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVMHHYWVEGNCPTKCDKCHKTV 328
            KQGLCC++CKYTVHERCV+R  P C+KTY K+KR+ +VM H WVEGN   KCD+CHK++
Sbjct: 296 RKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSI 355

Query: 329 KCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSV 388
           KCYQ +T  HCVWC++T H KC   L   CD G L+DHIL PT+ICP+            
Sbjct: 356 KCYQSVTARHCVWCRMTFHRKC--ELSTLCDGGELRDHILLPTSICPIT----------- 402

Query: 389 PEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSG 448
                    +++ G +    V  K ++             ++ P PGTHPLLV VNPKSG
Sbjct: 403 ---------RDRPGEKSDGCVSAKGELVMQ---------YKIIPTPGTHPLLVLVNPKSG 444

Query: 449 GKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIE 508
           G+QGER                         LNFFRD PDFRVLACGGDGTVGW+LDCI+
Sbjct: 445 GRQGER-------------------------LNFFRDTPDFRVLACGGDGTVGWILDCID 479

Query: 509 KANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIP 568
           KAN  KHPPVA+LPLGTGNDLARCLRWGGGYEG +L KILKDIE S  +MLDRW  EVIP
Sbjct: 480 KANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIP 539

Query: 569 NDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSET 628
            ++ E GD VPYSI+NNYFSIGVDASIAHRFH+MREKHPEKFNSRMKNK WYFEFGTSET
Sbjct: 540 REEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSET 599

Query: 629 FSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEK 688
           F+ATCKKLH+ +E+ECDGV +DL NI LEGIAILNIPSM+GG+NLWGE+KK R+  R  +
Sbjct: 600 FAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESR 659

Query: 689 KGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVI 748
           KG      VTD KELKF  QDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQC+ V I
Sbjct: 660 KG------VTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTI 713

Query: 749 RTSKSLPMQIDGEPWMQTPCTV 770
           RT+K LPMQ+DGEPWMQ  CT+
Sbjct: 714 RTNKLLPMQVDGEPWMQPCCTI 735


>gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
          Length = 735

 Score =  850 bits (2197), Expect = 0.0
 Identities = 429/767 (55%), Positives = 536/767 (69%), Gaps = 71/767 (9%)

Query: 10  LSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGFKLFMKT 69
           +SPS+F+QLQKY EYSTKK+ DVL+ F  +G +AKY       +    I +EGF+ F+K 
Sbjct: 8   ISPSDFAQLQKYMEYSTKKVSDVLKLFE-DGEMAKY-------VQGDAIGYEGFQQFLKI 59

Query: 70  FLEAE-LPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTSPANTC 128
           +LE + +P   +  LF SF                    G  +N+  +T           
Sbjct: 60  YLEVDNVPRHLSLALFQSFET------------------GHCLNETNVTK---------- 91

Query: 129 SPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYL 188
             +V+ L D+ CY SLLE GRPEDKLEF F+LYDTD NG LDSSE++ II QMM VAEYL
Sbjct: 92  --DVVCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYL 149

Query: 189 EWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWR 248
           +WDV+EL PIL EMM+EIDYD  G+VS  EW++ G TT+PLLVLLGLE  +KDDGQH+WR
Sbjct: 150 DWDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTVPLLVLLGLEMTLKDDGQHMWR 209

Query: 249 LKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVM 308
            K F +P YCNLC +  IG+GKQGL C+ CKYTVH++C  +A P  + TY KS+++  V 
Sbjct: 210 PKRFPRPVYCNLCESS-IGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQ 268

Query: 309 HHYWVEGNCPT-KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHI 367
            H WV G C + +CD+C K ++ Y  LTGLHCVWC + +H+ C   +  ECDCG L+DHI
Sbjct: 269 SHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHI 328

Query: 368 LPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQG 427
           LPP++I P VL + P                ++  S+   K +D   +  + ++ +D   
Sbjct: 329 LPPSSIYPSVLASGP----------------DRKNSKTSQKTMDDLNLSTSEALRID--- 369

Query: 428 LQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVP 487
               PVP THPLLVFVNPKSGGKQG+R+  KFQY+LNPRQV++L  +GP  GL  F+DVP
Sbjct: 370 ----PVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVP 425

Query: 488 DFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKI 547
           D R+L CGGDGTVGW+L+ I+KAN+   PPVA+LPLGTGNDLARCLRWGGGYEG+NL KI
Sbjct: 426 DSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKI 485

Query: 548 LKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHP 607
           LKD+E S  + +DRW  EVIP   +EK DPVP+ IINNYFSIGVDASIAHRFHIMREK+P
Sbjct: 486 LKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYP 545

Query: 608 EKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSM 667
           EKFNSRMKNK WYFEF TSE+  +TCKKL ES+ +E  G  +DL N+SLEGIA+LNIPSM
Sbjct: 546 EKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSM 605

Query: 668 HGGSNLWGESKKRRSHRRI----EKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGA 723
           HGGSNLWG++  RR H  I    +  G+  +  +TD   LK    DLSD+ LEVVGLEGA
Sbjct: 606 HGGSNLWGDT--RRPHGDIYGINQALGATAK-VITDPDILKTCVPDLSDKRLEVVGLEGA 662

Query: 724 MEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTV 770
           +EMGQIYT LK+AGRRLA+CS +   T+K+LPMQIDGEPWMQTPCT+
Sbjct: 663 IEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTI 709


>gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
          Length = 735

 Score =  850 bits (2197), Expect = 0.0
 Identities = 429/767 (55%), Positives = 536/767 (69%), Gaps = 71/767 (9%)

Query: 10  LSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGFKLFMKT 69
           +SPS+F+QLQKY EYSTKK+ DVL+ F  +G +AKY       +    I +EGF+ F+K 
Sbjct: 8   ISPSDFAQLQKYMEYSTKKVSDVLKLFE-DGEMAKY-------VQGDAIGYEGFQQFLKI 59

Query: 70  FLEAE-LPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTSPANTC 128
           +LE + +P   +  LF SF                    G  +N+  +T           
Sbjct: 60  YLEVDNVPRHLSLALFQSFET------------------GHCLNETNVTK---------- 91

Query: 129 SPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYL 188
             +V+ L D+ CY SLLE GRPEDKLEF F+LYDTD NG LDSSE++ II QMM VAEYL
Sbjct: 92  --DVVCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYL 149

Query: 189 EWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWR 248
           +WDV+EL PIL EMM+EIDYD  G+VS  EW++ G TT+PLLVLLGLE  +KDDGQH+WR
Sbjct: 150 DWDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTVPLLVLLGLEMTLKDDGQHMWR 209

Query: 249 LKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVM 308
            K F +P YCNLC +  IG+GKQGL C+ CKYTVH++C  +A P  + TY KS+++  V 
Sbjct: 210 PKRFPRPVYCNLCESS-IGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQ 268

Query: 309 HHYWVEGNCPT-KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHI 367
            H WV G C + +CD+C K ++ Y  LTGLHCVWC + +H+ C   +  ECDCG L+DHI
Sbjct: 269 SHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHI 328

Query: 368 LPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQG 427
           LPP++I P VL + P                ++  S+   K +D   +  + ++ +D   
Sbjct: 329 LPPSSIYPSVLASGP----------------DRKNSKTSQKTMDDLNLSTSEALRID--- 369

Query: 428 LQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVP 487
               PVP THPLLVFVNPKSGGKQG+R+  KFQY+LNPRQV++L  +GP  GL  F+DVP
Sbjct: 370 ----PVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVP 425

Query: 488 DFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKI 547
           D R+L CGGDGTVGW+L+ I+KAN+   PPVA+LPLGTGNDLARCLRWGGGYEG+NL KI
Sbjct: 426 DSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKI 485

Query: 548 LKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHP 607
           LKD+E S  + +DRW  EVIP   +EK DPVP+ IINNYFSIGVDASIAHRFHIMREK+P
Sbjct: 486 LKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYP 545

Query: 608 EKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSM 667
           EKFNSRMKNK WYFEF TSE+  +TCKKL ES+ +E  G  +DL N+SLEGIA+LNIPSM
Sbjct: 546 EKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSM 605

Query: 668 HGGSNLWGESKKRRSHRRI----EKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGA 723
           HGGSNLWG++  RR H  I    +  G+  +  +TD   LK    DLSD+ LEVVGLEGA
Sbjct: 606 HGGSNLWGDT--RRPHGDIYGINQALGATAK-VITDPDILKTCVPDLSDKRLEVVGLEGA 662

Query: 724 MEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTV 770
           +EMGQIYT LK+AGRRLA+CS +   T+K+LPMQIDGEPWMQTPCT+
Sbjct: 663 IEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTI 709


>gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
          Length = 735

 Score =  850 bits (2197), Expect = 0.0
 Identities = 429/767 (55%), Positives = 536/767 (69%), Gaps = 71/767 (9%)

Query: 10  LSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGFKLFMKT 69
           +SPS+F+QLQKY EYSTKK+ DVL+ F  +G +AKY       +    I +EGF+ F+K 
Sbjct: 8   ISPSDFAQLQKYMEYSTKKVSDVLKLFE-DGEMAKY-------VQGDAIGYEGFQQFLKI 59

Query: 70  FLEAE-LPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTSPANTC 128
           +LE + +P   +  LF SF                    G  +N+  +T           
Sbjct: 60  YLEVDNVPRHLSLALFQSFET------------------GHCLNETNVTK---------- 91

Query: 129 SPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYL 188
             +V+ L D+ CY SLLE GRPEDKLEF F+LYDTD NG LDSSE++ II QMM VAEYL
Sbjct: 92  --DVVCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYL 149

Query: 189 EWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWR 248
           +WDV+EL PIL EMM+EIDYD  G+VS  EW++ G TT+PLLVLLGLE  +KDDGQH+WR
Sbjct: 150 DWDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTVPLLVLLGLEMTLKDDGQHMWR 209

Query: 249 LKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVM 308
            K F +P YCNLC +  IG+GKQGL C+ CKYTVH++C  +A P  + TY KS+++  V 
Sbjct: 210 PKRFPRPVYCNLCESS-IGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQ 268

Query: 309 HHYWVEGNCPT-KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHI 367
            H WV G C + +CD+C K ++ Y  LTGLHCVWC + +H+ C   +  ECDCG L+DHI
Sbjct: 269 SHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHI 328

Query: 368 LPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQG 427
           LPP++I P VL + P                ++  S+   K +D   +  + ++ +D   
Sbjct: 329 LPPSSIYPSVLASGP----------------DRKNSKTSQKTMDDLNLSTSEALRID--- 369

Query: 428 LQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVP 487
               PVP THPLLVFVNPKSGGKQG+R+  KFQY+LNPRQV++L  +GP  GL  F+DVP
Sbjct: 370 ----PVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVP 425

Query: 488 DFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKI 547
           D R+L CGGDGTVGW+L+ I+KAN+   PPVA+LPLGTGNDLARCLRWGGGYEG+NL KI
Sbjct: 426 DSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKI 485

Query: 548 LKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHP 607
           LKD+E S  + +DRW  EVIP   +EK DPVP+ IINNYFSIGVDASIAHRFHIMREK+P
Sbjct: 486 LKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYP 545

Query: 608 EKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSM 667
           EKFNSRMKNK WYFEF TSE+  +TCKKL ES+ +E  G  +DL N+SLEGIA+LNIPSM
Sbjct: 546 EKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSM 605

Query: 668 HGGSNLWGESKKRRSHRRI----EKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGA 723
           HGGSNLWG++  RR H  I    +  G+  +  +TD   LK    DLSD+ LEVVGLEGA
Sbjct: 606 HGGSNLWGDT--RRPHGDIYGINQALGATAK-VITDPDILKTCVPDLSDKRLEVVGLEGA 662

Query: 724 MEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTV 770
           +EMGQIYT LK+AGRRLA+CS +   T+K+LPMQIDGEPWMQTPCT+
Sbjct: 663 IEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTI 709


>gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
          Length = 735

 Score =  850 bits (2197), Expect = 0.0
 Identities = 429/767 (55%), Positives = 536/767 (69%), Gaps = 71/767 (9%)

Query: 10  LSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGFKLFMKT 69
           +SPS+F+QLQKY EYSTKK+ DVL+ F  +G +AKY       +    I +EGF+ F+K 
Sbjct: 8   ISPSDFAQLQKYMEYSTKKVSDVLKLFE-DGEMAKY-------VQGDAIGYEGFQQFLKI 59

Query: 70  FLEAE-LPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTSPANTC 128
           +LE + +P   +  LF SF                    G  +N+  +T           
Sbjct: 60  YLEVDNVPRHLSLALFQSFET------------------GHCLNETNVTK---------- 91

Query: 129 SPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYL 188
             +V+ L D+ CY SLLE GRPEDKLEF F+LYDTD NG LDSSE++ II QMM VAEYL
Sbjct: 92  --DVVCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYL 149

Query: 189 EWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWR 248
           +WDV+EL PIL EMM+EIDYD  G+VS  EW++ G TT+PLLVLLGLE  +KDDGQH+WR
Sbjct: 150 DWDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTVPLLVLLGLEMTLKDDGQHMWR 209

Query: 249 LKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVM 308
            K F +P YCNLC +  IG+GKQGL C+ CKYTVH++C  +A P  + TY KS+++  V 
Sbjct: 210 PKRFPRPVYCNLCESS-IGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQ 268

Query: 309 HHYWVEGNCPT-KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHI 367
            H WV G C + +CD+C K ++ Y  LTGLHCVWC + +H+ C   +  ECDCG L+DHI
Sbjct: 269 SHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHI 328

Query: 368 LPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQG 427
           LPP++I P VL + P                ++  S+   K +D   +  + ++ +D   
Sbjct: 329 LPPSSIYPSVLASGP----------------DRKNSKTSQKTMDDLNLSTSEALRID--- 369

Query: 428 LQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVP 487
               PVP THPLLVFVNPKSGGKQG+R+  KFQY+LNPRQV++L  +GP  GL  F+DVP
Sbjct: 370 ----PVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVP 425

Query: 488 DFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKI 547
           D R+L CGGDGTVGW+L+ I+KAN+   PPVA+LPLGTGNDLARCLRWGGGYEG+NL KI
Sbjct: 426 DSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKI 485

Query: 548 LKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHP 607
           LKD+E S  + +DRW  EVIP   +EK DPVP+ IINNYFSIGVDASIAHRFHIMREK+P
Sbjct: 486 LKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYP 545

Query: 608 EKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSM 667
           EKFNSRMKNK WYFEF TSE+  +TCKKL ES+ +E  G  +DL N+SLEGIA+LNIPSM
Sbjct: 546 EKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSM 605

Query: 668 HGGSNLWGESKKRRSHRRI----EKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGA 723
           HGGSNLWG++  RR H  I    +  G+  +  +TD   LK    DLSD+ LEVVGLEGA
Sbjct: 606 HGGSNLWGDT--RRPHGDIYGINQALGATAK-VITDPDILKTCVPDLSDKRLEVVGLEGA 662

Query: 724 MEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTV 770
           +EMGQIYT LK+AGRRLA+CS +   T+K+LPMQIDGEPWMQTPCT+
Sbjct: 663 IEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTI 709


>gi|124256482 diacylglycerol kinase gamma isoform 3 [Homo sapiens]
          Length = 752

 Score =  823 bits (2126), Expect = 0.0
 Identities = 432/802 (53%), Positives = 524/802 (65%), Gaps = 118/802 (14%)

Query: 4   QEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGF 63
           +E+W  L+P EF QLQKY+EYS+KK+KD L EF+  G L +Y+P       ++ I ++ F
Sbjct: 3   EERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDP-------HEPISYDVF 55

Query: 64  KLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTS 123
           KLFM+ +LE +LP   + HLF++FS K  H +    ++ A  S     +         T 
Sbjct: 56  KLFMRAYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATK 115

Query: 124 PANTCSPE----------------------------------VIHLKDIVCYLSLLERGR 149
               C+P+                                  V++LKD+VCYLSLLE GR
Sbjct: 116 ADEACAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGR 175

Query: 150 PEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYLEWDVTELNPILHEMMEEIDYD 209
           P+DKLEFMFRLYD+D NG LD +E++ I++QM+H+A+YLEWD TEL PIL EM++ +DYD
Sbjct: 176 PQDKLEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYD 235

Query: 210 HDGTVSLEEWIQGGMTTIPLLVLLGLENN-VKDDGQHVWRLKHFNKPAYCNLCLNMLIGV 268
            DG VSL+EW+ GGMTTIPLLVLLG++++  K DG+H W +KHF KP Y           
Sbjct: 236 RDGFVSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTY----------- 284

Query: 269 GKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVMHHYWVEGNCPTKCDKCHKTV 328
                 C+FC    H   +         TY K       +H   V  N P  C K +   
Sbjct: 285 ------CNFC----HIMLMGVRKQGLCCTYCKY-----TVHERCVSRNIPG-CVKTYSKA 328

Query: 329 KCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSV 388
           K     +G          H KC   L   CD G L+DHIL PT+ICP+            
Sbjct: 329 K----RSG--------EFHRKC--ELSTLCDGGELRDHILLPTSICPIT----------- 363

Query: 389 PEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSG 448
                    +++ G +    V  K ++             ++ P PGTHPLLV VNPKSG
Sbjct: 364 ---------RDRPGEKSDGCVSAKGELVMQ---------YKIIPTPGTHPLLVLVNPKSG 405

Query: 449 GKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIE 508
           G+QGERI RKF YLLNP+QV++L   GP PGLNFFRD PDFRVLACGGDGTVGW+LDCI+
Sbjct: 406 GRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDFRVLACGGDGTVGWILDCID 465

Query: 509 KANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIP 568
           KAN  KHPPVA+LPLGTGNDLARCLRWGGGYEG +L KILKDIE S  +MLDRW  EVIP
Sbjct: 466 KANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIP 525

Query: 569 NDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSET 628
            ++ E GD VPYSI+NNYFSIGVDASIAHRFH+MREKHPEKFNSRMKNK WYFEFGTSET
Sbjct: 526 REEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSET 585

Query: 629 FSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEK 688
           F+ATCKKLH+ +E+ECDGV +DL NI LEGIAILNIPSM+GG+NLWGE+KK R+  R  +
Sbjct: 586 FAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESR 645

Query: 689 KGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVI 748
           KG      VTD KELKF  QDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQC+ V I
Sbjct: 646 KG------VTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTI 699

Query: 749 RTSKSLPMQIDGEPWMQTPCTV 770
           RT+K LPMQ+DGEPWMQ  CT+
Sbjct: 700 RTNKLLPMQVDGEPWMQPCCTI 721


>gi|4758156 diacylglycerol kinase, iota [Homo sapiens]
          Length = 1065

 Score =  293 bits (751), Expect = 3e-79
 Identities = 195/584 (33%), Positives = 275/584 (47%), Gaps = 80/584 (13%)

Query: 220 IQGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNLCL----NMLIGVGKQGLC- 274
           +  G    P   L   EN V  +G+H+W   + +     +LC     N  +   K  L  
Sbjct: 155 VANGPAKEPRATLDWSENAV--NGEHLWLETNVSG----DLCYLGEENCQVRFAKSALRR 208

Query: 275 -CSFCKYTVHERCVA-------RAPPSCIKTYVKSKRNTDVMHHYWVEGNCPTKCDKCHK 326
            C+ CK  VH  C+        R  P+  +   +S R   V HH+        KC +C K
Sbjct: 209 KCAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGK 268

Query: 327 TVKCY-----QGLTGLHCVWCQITLHNKCAS----HLKPECDCGPLKDHILPPTTICPVV 377
             +       + +  + C WC+   HNK       H++  C  G     I+PPT I  V 
Sbjct: 269 GFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVK 328

Query: 378 LQTLPTSGVSVPEERQSTVKK-EKSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPV--P 434
                    +  ++R S  +K  K G +Q NK                G+   + P+  P
Sbjct: 329 KPQNSLKASNRKKKRTSFKRKASKRGMEQENK----------------GRPFVIKPISSP 372

Query: 435 GTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLAC 494
              PLLVFVNPKSGG QG ++ + F + LNPRQV+ LS  GP   L  +R VP+ R+LAC
Sbjct: 373 LMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILAC 432

Query: 495 GGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENS 554
           GGDGTVGW+L  +++  +   PPV +LPLGTGNDLAR L WGGGY  E + KIL  +E+ 
Sbjct: 433 GGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDG 492

Query: 555 TEIMLDRWKFEV-----IPNDKDEKG-DPVPYSIINNYFSIGVDASIAHRFHIMREKHPE 608
           T + LDRW   V     +P ++ E G   +P ++ NNYFS+G DA +   FH  RE +PE
Sbjct: 493 TVVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPE 552

Query: 609 KFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQI--DLINISLEGIAILNIPS 666
           KFNSR +NK +Y     S+    + + L + V++ CDG  +   +  +  + I  LNIP 
Sbjct: 553 KFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQELKFQCIVFLNIPR 612

Query: 667 MHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGAMEM 726
              G+  WG                             F  Q   D  +EV+G   A  +
Sbjct: 613 YCAGTMPWGNPGDHHD----------------------FEPQRHDDGYIEVIGFTMA-SL 649

Query: 727 GQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTV 770
             +  G    G RL QC  V++ T KS+PMQ+DGEP    P  +
Sbjct: 650 AALQVG--GHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMI 691


>gi|41872507 diacylglycerol kinase zeta isoform 2 [Homo sapiens]
          Length = 929

 Score =  285 bits (730), Expect = 9e-77
 Identities = 182/554 (32%), Positives = 267/554 (48%), Gaps = 79/554 (14%)

Query: 243 GQHVWRLKHFNKPAYCNL----CLNMLIGVGKQGLCCSFCKYTVHERCVA-------RAP 291
           G+H+W   + +   +C +    C+  ++        C+ CK  VH  C+        R  
Sbjct: 96  GEHIWFETNVSGD-FCYVGEQYCVARMLQKSVSRRKCAACKIVVHTPCIEQLEKINFRCK 154

Query: 292 PSCIKTYVKSKRNTDVMHHYWVEGNCPT-KCDKCHKTVKCY-----QGLTGLHCVWCQIT 345
           PS  ++  ++ R    + H+WV       KC  C K  +       + +  + C WC+  
Sbjct: 155 PSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQA 214

Query: 346 LHNKCA----SHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKS 401
            H+K +      ++  C  G     ++PPT I   +    P + +   ++++    K KS
Sbjct: 215 YHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWI---LRARRPQNTLKASKKKKRASFKRKS 271

Query: 402 GSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQY 461
             + P +   +  + R             TP P   PLLVFVNPKSGG QG +I + F +
Sbjct: 272 SKKGPEEGRWRPFIIRP------------TPSPLMKPLLVFVNPKSGGNQGAKIIQSFLW 319

Query: 462 LLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAIL 521
            LNPRQV+ LS  GP   L  +R V + R+LACGGDGTVGW+L  +++  +   PPVAIL
Sbjct: 320 YLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAIL 379

Query: 522 PLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIPN------DKDEKG 575
           PLGTGNDLAR L WGGGY  E + KIL  +E    + LDRW     PN      D+DE  
Sbjct: 380 PLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGA 439

Query: 576 -DPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCK 634
            D +P  + NNYFS+G DA +   FH  RE +PEKFNSR +NK +Y     S+    + K
Sbjct: 440 TDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSK 499

Query: 635 KLHESVEIECDGVQI--DLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSD 692
            L + + + CDG+ +   + ++  + +  LNIP    G+  WG   +             
Sbjct: 500 DLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD---------- 549

Query: 693 KRTTVTDAKELKFASQDLSDQLLEVVGLE----GAMEMGQIYTGLKSAGRRLAQCSCVVI 748
                       F  Q   D  LEV+G       A+++G         G RL QC  VV+
Sbjct: 550 ------------FEPQRHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREVVL 590

Query: 749 RTSKSLPMQIDGEP 762
            TSK++P+Q+DGEP
Sbjct: 591 TTSKAIPVQVDGEP 604


>gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens]
          Length = 895

 Score =  285 bits (730), Expect = 9e-77
 Identities = 182/554 (32%), Positives = 267/554 (48%), Gaps = 79/554 (14%)

Query: 243 GQHVWRLKHFNKPAYCNL----CLNMLIGVGKQGLCCSFCKYTVHERCVA-------RAP 291
           G+H+W   + +   +C +    C+  ++        C+ CK  VH  C+        R  
Sbjct: 62  GEHIWFETNVSGD-FCYVGEQYCVARMLQKSVSRRKCAACKIVVHTPCIEQLEKINFRCK 120

Query: 292 PSCIKTYVKSKRNTDVMHHYWVEGNCPT-KCDKCHKTVKCY-----QGLTGLHCVWCQIT 345
           PS  ++  ++ R    + H+WV       KC  C K  +       + +  + C WC+  
Sbjct: 121 PSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQA 180

Query: 346 LHNKCA----SHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKS 401
            H+K +      ++  C  G     ++PPT I   +    P + +   ++++    K KS
Sbjct: 181 YHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWI---LRARRPQNTLKASKKKKRASFKRKS 237

Query: 402 GSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQY 461
             + P +   +  + R             TP P   PLLVFVNPKSGG QG +I + F +
Sbjct: 238 SKKGPEEGRWRPFIIRP------------TPSPLMKPLLVFVNPKSGGNQGAKIIQSFLW 285

Query: 462 LLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAIL 521
            LNPRQV+ LS  GP   L  +R V + R+LACGGDGTVGW+L  +++  +   PPVAIL
Sbjct: 286 YLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAIL 345

Query: 522 PLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIPN------DKDEKG 575
           PLGTGNDLAR L WGGGY  E + KIL  +E    + LDRW     PN      D+DE  
Sbjct: 346 PLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGA 405

Query: 576 -DPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCK 634
            D +P  + NNYFS+G DA +   FH  RE +PEKFNSR +NK +Y     S+    + K
Sbjct: 406 TDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSK 465

Query: 635 KLHESVEIECDGVQI--DLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSD 692
            L + + + CDG+ +   + ++  + +  LNIP    G+  WG   +             
Sbjct: 466 DLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD---------- 515

Query: 693 KRTTVTDAKELKFASQDLSDQLLEVVGLE----GAMEMGQIYTGLKSAGRRLAQCSCVVI 748
                       F  Q   D  LEV+G       A+++G         G RL QC  VV+
Sbjct: 516 ------------FEPQRHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREVVL 556

Query: 749 RTSKSLPMQIDGEP 762
            TSK++P+Q+DGEP
Sbjct: 557 TTSKAIPVQVDGEP 570


>gi|157688564 diacylglycerol kinase zeta isoform 4 [Homo sapiens]
          Length = 1117

 Score =  285 bits (729), Expect = 1e-76
 Identities = 185/556 (33%), Positives = 267/556 (48%), Gaps = 84/556 (15%)

Query: 243 GQHVWRLKHFNKP------AYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVA-------R 289
           G+H+W   + +         YC     ML  V ++   C+ CK  VH  C+        R
Sbjct: 285 GEHIWFETNVSGDFCYVGEQYC--VARMLKSVSRRK--CAACKIVVHTPCIEQLEKINFR 340

Query: 290 APPSCIKTYVKSKRNTDVMHHYWVEGNCPT-KCDKCHKTVKCY-----QGLTGLHCVWCQ 343
             PS  ++  ++ R    + H+WV       KC  C K  +       + +  + C WC+
Sbjct: 341 CKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCK 400

Query: 344 ITLHNKCA----SHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKE 399
              H+K +      ++  C  G     ++PPT I   +    P + +   ++++    K 
Sbjct: 401 QAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWI---LRARRPQNTLKASKKKKRASFKR 457

Query: 400 KSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKF 459
           KS  + P +   +  + R             TP P   PLLVFVNPKSGG QG +I + F
Sbjct: 458 KSSKKGPEEGRWRPFIIRP------------TPSPLMKPLLVFVNPKSGGNQGAKIIQSF 505

Query: 460 QYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVA 519
            + LNPRQV+ LS  GP   L  +R V + R+LACGGDGTVGW+L  +++  +   PPVA
Sbjct: 506 LWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVA 565

Query: 520 ILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIPN------DKDE 573
           ILPLGTGNDLAR L WGGGY  E + KIL  +E    + LDRW     PN      D+DE
Sbjct: 566 ILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDE 625

Query: 574 KG-DPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSAT 632
              D +P  + NNYFS+G DA +   FH  RE +PEKFNSR +NK +Y     S+    +
Sbjct: 626 GATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGS 685

Query: 633 CKKLHESVEIECDGVQI--DLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKG 690
            K L + + + CDG+ +   + ++  + +  LNIP    G+  WG   +           
Sbjct: 686 SKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD-------- 737

Query: 691 SDKRTTVTDAKELKFASQDLSDQLLEVVGLE----GAMEMGQIYTGLKSAGRRLAQCSCV 746
                         F  Q   D  LEV+G       A+++G         G RL QC  V
Sbjct: 738 --------------FEPQRHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREV 776

Query: 747 VIRTSKSLPMQIDGEP 762
           V+ TSK++P+Q+DGEP
Sbjct: 777 VLTTSKAIPVQVDGEP 792


>gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens]
          Length = 945

 Score =  285 bits (729), Expect = 1e-76
 Identities = 185/556 (33%), Positives = 267/556 (48%), Gaps = 84/556 (15%)

Query: 243 GQHVWRLKHFNKP------AYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVA-------R 289
           G+H+W   + +         YC     ML  V ++   C+ CK  VH  C+        R
Sbjct: 113 GEHIWFETNVSGDFCYVGEQYC--VARMLKSVSRRK--CAACKIVVHTPCIEQLEKINFR 168

Query: 290 APPSCIKTYVKSKRNTDVMHHYWVEGNCPT-KCDKCHKTVKCY-----QGLTGLHCVWCQ 343
             PS  ++  ++ R    + H+WV       KC  C K  +       + +  + C WC+
Sbjct: 169 CKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCK 228

Query: 344 ITLHNKCA----SHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKE 399
              H+K +      ++  C  G     ++PPT I   +    P + +   ++++    K 
Sbjct: 229 QAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWI---LRARRPQNTLKASKKKKRASFKR 285

Query: 400 KSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKF 459
           KS  + P +   +  + R             TP P   PLLVFVNPKSGG QG +I + F
Sbjct: 286 KSSKKGPEEGRWRPFIIRP------------TPSPLMKPLLVFVNPKSGGNQGAKIIQSF 333

Query: 460 QYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVA 519
            + LNPRQV+ LS  GP   L  +R V + R+LACGGDGTVGW+L  +++  +   PPVA
Sbjct: 334 LWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVA 393

Query: 520 ILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIPN------DKDE 573
           ILPLGTGNDLAR L WGGGY  E + KIL  +E    + LDRW     PN      D+DE
Sbjct: 394 ILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDE 453

Query: 574 KG-DPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSAT 632
              D +P  + NNYFS+G DA +   FH  RE +PEKFNSR +NK +Y     S+    +
Sbjct: 454 GATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGS 513

Query: 633 CKKLHESVEIECDGVQI--DLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKG 690
            K L + + + CDG+ +   + ++  + +  LNIP    G+  WG   +           
Sbjct: 514 SKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD-------- 565

Query: 691 SDKRTTVTDAKELKFASQDLSDQLLEVVGLE----GAMEMGQIYTGLKSAGRRLAQCSCV 746
                         F  Q   D  LEV+G       A+++G         G RL QC  V
Sbjct: 566 --------------FEPQRHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREV 604

Query: 747 VIRTSKSLPMQIDGEP 762
           V+ TSK++P+Q+DGEP
Sbjct: 605 VLTTSKAIPVQVDGEP 620


>gi|4503313 diacylglycerol kinase epsilon [Homo sapiens]
          Length = 567

 Score =  273 bits (697), Expect = 6e-73
 Identities = 186/543 (34%), Positives = 264/543 (48%), Gaps = 83/543 (15%)

Query: 244 QHVWR-LKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSK 302
           +H WR    F++P YC +C   ++    QG  C  C   V E C+ +A        +  K
Sbjct: 59  KHGWRDTDLFSQPTYCCVCAQHIL----QGAFCDCCGLRVDEGCLRKADKRFQCKEIMLK 114

Query: 303 RNT---DVMHHYWVEGNCP--TKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASH-LKP 356
            +T   D M H+W+ GN P  + C  C +   C   L    C+WCQ T+H++C  + LK 
Sbjct: 115 NDTKVLDAMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMKNSLKN 174

Query: 357 E-CDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKM 415
           E CD G  K+ I+PP+ +  +                 + ++K+K    +          
Sbjct: 175 EKCDFGEFKNLIIPPSYLTSI-----------------NQMRKDKKTDYE---------- 207

Query: 416 QRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNG 475
                V     G Q TP      L++  N +SG   GE +  +F+ LLNP QV+ ++   
Sbjct: 208 -----VLASKLGKQWTP------LIILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTP 256

Query: 476 PMPGLNFFRDVPDF--RVLACGGDGTVGWVLDCIEKANVGKH----PPVAILPLGTGNDL 529
           P+  L     +P +  RVL CGGDGTVGWVLD ++   +       P VA+LPLGTGNDL
Sbjct: 257 PIKALQLCTLLPYYSARVLVCGGDGTVGWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDL 316

Query: 530 ARCLRWGGGYEGE-NLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFS 588
           +  L WG GY GE  + ++L+++  +  I LDRWK +V          P  +++ NNYFS
Sbjct: 317 SNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDRWKVQVTNKGYYNLRKPKEFTM-NNYFS 375

Query: 589 IGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQ 648
           +G DA +A  FH  REK P  F+SR+ NK  Y  +GT +     CK L++ VE+E DG +
Sbjct: 376 VGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKVELELDGER 435

Query: 649 IDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQ 708
           + L   SLEGI +LNI    GG  LW            E  G +             A  
Sbjct: 436 VAL--PSLEGIIVLNIGYWGGGCRLW------------EGMGDE---------TYPLARH 472

Query: 709 DLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPC 768
           D  D LLEVVG+ G+    QI   L +  R     +  +I     +PMQ+DGEPW Q PC
Sbjct: 473 D--DGLLEVVGVYGSFHCAQIQVKLANPFRIGQAHTVRLILKCSMMPMQVDGEPWAQGPC 530

Query: 769 TVS 771
           TV+
Sbjct: 531 TVT 533


>gi|40806175 diacylglycerol kinase, theta [Homo sapiens]
          Length = 942

 Score =  254 bits (648), Expect = 3e-67
 Identities = 141/343 (41%), Positives = 200/343 (58%), Gaps = 37/343 (10%)

Query: 434 PGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLA 493
           P + PLLVFVNPKSGG +G  +   F+ LLNP QV+ L+  GP+PGL+ F  VP FRVL 
Sbjct: 584 PDSCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLV 643

Query: 494 CGGDGTVGWVLDCIEKAN---VGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKD 550
           CGGDGTVGWVL  +E+         P VAILPLGTGNDL R LRWG GY GE+   +L  
Sbjct: 644 CGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLLS 703

Query: 551 IENSTEIMLDRWKFEVIPND----KDEKGDPVPYSII--NNYFSIGVDASIAHRFHIMRE 604
           ++ +  +++DRW   +  ++    +++  D  P  I+  +NY  IG+DA ++  FH  RE
Sbjct: 704 VDEADAVLMDRWTILLDAHEAGSAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQARE 763

Query: 605 KHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIAILNI 664
           + P KF SR+ NK  Y   G  +   +  + LH+ + ++ +  +++L   S+EG+  +NI
Sbjct: 764 EEPGKFTSRLHNKGVYVRVGLQKI--SHSRSLHKQIRLQVERQEVEL--PSIEGLIFINI 819

Query: 665 PSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGAM 724
           PS   G++LW               GSD  T        +F    + D LLEVVG+ G +
Sbjct: 820 PSWGSGADLW---------------GSDSDT--------RFEKPRMDDGLLEVVGVTGVV 856

Query: 725 EMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTP 767
            MGQ+  GL+S G R+AQ S   +   K+ P+Q+DGEPW+Q P
Sbjct: 857 HMGQVQGGLRS-GIRIAQGSYFRVTLLKATPVQVDGEPWVQAP 898



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 41/131 (31%), Positives = 65/131 (49%), Gaps = 5/131 (3%)

Query: 245 HVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRN 304
           H +  +  +K  +C +C  +L       L C  C+  +H  CV  A   C + +    ++
Sbjct: 122 HCFGPRGLHKRKFCAVCRKVLEA---PALHCEVCELHLHPDCVPFACSDCRQCHQDGHQD 178

Query: 305 TDVMHHYWVEGNCPT--KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGP 362
            D  HH+W EGN P+  +C+ C KT      L G+ C WC +  H+ C++ L PEC  G 
Sbjct: 179 HDTHHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGR 238

Query: 363 LKDHILPPTTI 373
           L+  +LPP  +
Sbjct: 239 LRSLVLPPACV 249



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 31/115 (26%), Positives = 47/115 (40%), Gaps = 8/115 (6%)

Query: 245 HVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRN 304
           H +R     KP +C+LC + + G+   G  C  C +  HE+C+      C  +   S   
Sbjct: 61  HSFRKVTLTKPTFCHLCSDFIWGLA--GFLCDVCNFMSHEKCLKHVRIPC-TSVAPSLVR 117

Query: 305 TDVMHHYWVEGNCPTK-CDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPEC 358
             V H +   G    K C  C K ++       LHC  C++ LH  C      +C
Sbjct: 118 VPVAHCFGPRGLHKRKFCAVCRKVLEA----PALHCEVCELHLHPDCVPFACSDC 168


>gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo
           sapiens]
          Length = 1170

 Score =  210 bits (534), Expect = 5e-54
 Identities = 120/330 (36%), Positives = 154/330 (46%), Gaps = 55/330 (16%)

Query: 243 GQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSK 302
           G H W      +P YCN+C   L GV   GL C  CK+  H+RC  RA  +C  T + S 
Sbjct: 118 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 177

Query: 303 RNTDV-------MHHYWVEGNCPT--KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASH 353
               +       M H W+EGN P   KC  C KT      L    C+WC+  +H  C   
Sbjct: 178 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 237

Query: 354 LKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKN 413
           L  +C  G  K  ++PPT +                                        
Sbjct: 238 LLTKCPLGLCKVSVIPPTAL---------------------------------------- 257

Query: 414 KMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSG 473
                NS+  DG      P   T PLLVFVN KSG  QG +  R+F+ LLNP QV+ L  
Sbjct: 258 -----NSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMN 312

Query: 474 NGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCL 533
            GP  GL  F+    FR+L CGGDG+VGWVL  I+  N+ K   + +LPLGTGNDLAR L
Sbjct: 313 GGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVL 372

Query: 534 RWGGGYEGE-NLMKILKDIENSTEIMLDRW 562
            WG   + +  L +IL+ +E ++  MLDRW
Sbjct: 373 GWGSACDDDTQLPQILEKLERASTKMLDRW 402



 Score =  127 bits (320), Expect = 3e-29
 Identities = 74/188 (39%), Positives = 104/188 (55%), Gaps = 27/188 (14%)

Query: 582 IINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVE 641
           ++NNYF IG+DA I+  F+  R++HPEK  SR KN  WY   GT E    T K L + V 
Sbjct: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778

Query: 642 IECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAK 701
           +ECDG  I L   SL+GIA+LNIPS  GG+N WG +K                      +
Sbjct: 779 LECDGRPIPL--PSLQGIAVLNIPSYAGGTNFWGGTK----------------------E 814

Query: 702 ELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRT--SKSLPMQID 759
           +  FA+    D++LEVV + G+M+M  +   ++    R+AQC  V I     + +P+Q+D
Sbjct: 815 DDTFAAPSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQVD 873

Query: 760 GEPWMQTP 767
           GE W+Q P
Sbjct: 874 GEAWVQPP 881


>gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo
           sapiens]
          Length = 1214

 Score =  210 bits (534), Expect = 5e-54
 Identities = 120/330 (36%), Positives = 154/330 (46%), Gaps = 55/330 (16%)

Query: 243 GQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSK 302
           G H W      +P YCN+C   L GV   GL C  CK+  H+RC  RA  +C  T + S 
Sbjct: 162 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 221

Query: 303 RNTDV-------MHHYWVEGNCPT--KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASH 353
               +       M H W+EGN P   KC  C KT      L    C+WC+  +H  C   
Sbjct: 222 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 281

Query: 354 LKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKN 413
           L  +C  G  K  ++PPT +                                        
Sbjct: 282 LLTKCPLGLCKVSVIPPTAL---------------------------------------- 301

Query: 414 KMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSG 473
                NS+  DG      P   T PLLVFVN KSG  QG +  R+F+ LLNP QV+ L  
Sbjct: 302 -----NSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMN 356

Query: 474 NGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCL 533
            GP  GL  F+    FR+L CGGDG+VGWVL  I+  N+ K   + +LPLGTGNDLAR L
Sbjct: 357 GGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVL 416

Query: 534 RWGGGYEGE-NLMKILKDIENSTEIMLDRW 562
            WG   + +  L +IL+ +E ++  MLDRW
Sbjct: 417 GWGSACDDDTQLPQILEKLERASTKMLDRW 446



 Score =  127 bits (320), Expect = 3e-29
 Identities = 74/188 (39%), Positives = 104/188 (55%), Gaps = 27/188 (14%)

Query: 582 IINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVE 641
           ++NNYF IG+DA I+  F+  R++HPEK  SR KN  WY   GT E    T K L + V 
Sbjct: 763 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 822

Query: 642 IECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAK 701
           +ECDG  I L   SL+GIA+LNIPS  GG+N WG +K                      +
Sbjct: 823 LECDGRPIPL--PSLQGIAVLNIPSYAGGTNFWGGTK----------------------E 858

Query: 702 ELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRT--SKSLPMQID 759
           +  FA+    D++LEVV + G+M+M  +   ++    R+AQC  V I     + +P+Q+D
Sbjct: 859 DDTFAAPSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQVD 917

Query: 760 GEPWMQTP 767
           GE W+Q P
Sbjct: 918 GEAWVQPP 925


>gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens]
          Length = 1164

 Score =  207 bits (526), Expect = 4e-53
 Identities = 121/330 (36%), Positives = 155/330 (46%), Gaps = 56/330 (16%)

Query: 243 GQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKS- 301
           G H W      +P +CN+C   L GV   GL C  CK+  H+RC  RA  +C  T + S 
Sbjct: 174 GMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 233

Query: 302 ------KRNTDVMHHYWVEGNCPT--KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASH 353
                   +   M H W+EGN P   KC  C KT      L    C+WC+  +H  C   
Sbjct: 234 GKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDL 293

Query: 354 LKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKN 413
             P C  G  K  I+PP  +                                        
Sbjct: 294 YHPICPLGQCKVSIIPPIAL---------------------------------------- 313

Query: 414 KMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSG 473
                NS   DG   + T      PLLVFVN KSG  QG +  R+F+ LLNP QV+ L  
Sbjct: 314 -----NSTDSDGF-CRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMN 367

Query: 474 NGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCL 533
            GP  GL  F+   +FR+L CGGDG+VGWVL  I+K N+ K   + +LPLGTGNDLAR L
Sbjct: 368 GGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARVL 427

Query: 534 RWGGGYEGE-NLMKILKDIENSTEIMLDRW 562
            WGG Y+ +  L +IL+ +E ++  MLDRW
Sbjct: 428 GWGGSYDDDTQLPQILEKLERASTKMLDRW 457



 Score =  127 bits (320), Expect = 3e-29
 Identities = 74/188 (39%), Positives = 104/188 (55%), Gaps = 27/188 (14%)

Query: 582 IINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVE 641
           ++NNYF IG+DA I+  F+  RE+HPEK  SR KN  WY   GT E    + K L + V+
Sbjct: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829

Query: 642 IECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAK 701
           +ECDG  I L   SL+GIA+LNIPS  GG+N WG +K                      +
Sbjct: 830 LECDGQYIPL--PSLQGIAVLNIPSYAGGTNFWGGTK----------------------E 865

Query: 702 ELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRT--SKSLPMQID 759
           +  FA+    D++LEVV +  +M+M  +   +K    R+AQC  V I     + +P+Q+D
Sbjct: 866 DDIFAAPSFDDKILEVVAIFDSMQMA-VSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVD 924

Query: 760 GEPWMQTP 767
           GE W+Q P
Sbjct: 925 GEAWVQPP 932


>gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens]
          Length = 1220

 Score =  207 bits (526), Expect = 4e-53
 Identities = 121/330 (36%), Positives = 155/330 (46%), Gaps = 56/330 (16%)

Query: 243 GQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKS- 301
           G H W      +P +CN+C   L GV   GL C  CK+  H+RC  RA  +C  T + S 
Sbjct: 174 GMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 233

Query: 302 ------KRNTDVMHHYWVEGNCPT--KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASH 353
                   +   M H W+EGN P   KC  C KT      L    C+WC+  +H  C   
Sbjct: 234 GKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDL 293

Query: 354 LKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKN 413
             P C  G  K  I+PP  +                                        
Sbjct: 294 YHPICPLGQCKVSIIPPIAL---------------------------------------- 313

Query: 414 KMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSG 473
                NS   DG   + T      PLLVFVN KSG  QG +  R+F+ LLNP QV+ L  
Sbjct: 314 -----NSTDSDGF-CRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMN 367

Query: 474 NGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCL 533
            GP  GL  F+   +FR+L CGGDG+VGWVL  I+K N+ K   + +LPLGTGNDLAR L
Sbjct: 368 GGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARVL 427

Query: 534 RWGGGYEGE-NLMKILKDIENSTEIMLDRW 562
            WGG Y+ +  L +IL+ +E ++  MLDRW
Sbjct: 428 GWGGSYDDDTQLPQILEKLERASTKMLDRW 457



 Score =  127 bits (320), Expect = 3e-29
 Identities = 74/188 (39%), Positives = 104/188 (55%), Gaps = 27/188 (14%)

Query: 582 IINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVE 641
           ++NNYF IG+DA I+  F+  RE+HPEK  SR KN  WY   GT E    + K L + V+
Sbjct: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829

Query: 642 IECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAK 701
           +ECDG  I L   SL+GIA+LNIPS  GG+N WG +K                      +
Sbjct: 830 LECDGQYIPL--PSLQGIAVLNIPSYAGGTNFWGGTK----------------------E 865

Query: 702 ELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRT--SKSLPMQID 759
           +  FA+    D++LEVV +  +M+M  +   +K    R+AQC  V I     + +P+Q+D
Sbjct: 866 DDIFAAPSFDDKILEVVAIFDSMQMA-VSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVD 924

Query: 760 GEPWMQTP 767
           GE W+Q P
Sbjct: 925 GEAWVQPP 932


>gi|62000702 diacylglycerol kinase kappa [Homo sapiens]
          Length = 1271

 Score =  183 bits (464), Expect = 6e-46
 Identities = 112/363 (30%), Positives = 166/363 (45%), Gaps = 59/363 (16%)

Query: 216 LEEWI-------QGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGV 268
           +EEWI       QG +  IP       ENN    G H W   + ++  +CN+C   +  +
Sbjct: 297 MEEWINIIKTIQQGEIYKIP-----AAENNPFLVGMHCWYSSYSHRTQHCNVCRESIPAL 351

Query: 269 GKQGLCCSFCKYTVHERCVARAPPSC------IKTYVKSKRNTDVMHHYWVEGNCP--TK 320
            +  + C  CK   H  C  RA   C      I   +    +   M H WVEGN P  ++
Sbjct: 352 SRDAIICEVCKVKSHRLCALRASKDCKWNTLSITDDLLLPADEVNMPHQWVEGNMPVSSQ 411

Query: 321 CDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHILPPTTICPVVLQT 380
           C  CH++   YQ L    C+WC  T+H+ C      EC     +  ++PPT +       
Sbjct: 412 CAVCHESCGSYQRLQDFRCLWCNSTVHDDCRRRFSKECCFRSHRSSVIPPTAL------- 464

Query: 381 LPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLL 440
                             +  G  Q     D   +  +++ +               PLL
Sbjct: 465 -----------------SDPKGDGQLVVSSDFWNLDWSSACSC--------------PLL 493

Query: 441 VFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTV 500
           +F+N KSG  QG    RKF+  LNP QV+ L   GP  GL+ F++   FR+L CGGDG+V
Sbjct: 494 IFINSKSGDHQGIVFLRKFKQYLNPSQVFDLLKGGPEAGLSMFKNFARFRILVCGGDGSV 553

Query: 501 GWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGY-EGENLMKILKDIENSTEIML 559
            WVL  I+   + +   +A++PLGTGNDLAR L WG  + + ++ + IL  +E ++  +L
Sbjct: 554 SWVLSLIDAFGLHEKCQLAVIPLGTGNDLARVLGWGAFWNKSKSPLDILNRVEQASVRIL 613

Query: 560 DRW 562
           DRW
Sbjct: 614 DRW 616



 Score =  120 bits (302), Expect = 4e-27
 Identities = 71/188 (37%), Positives = 103/188 (54%), Gaps = 27/188 (14%)

Query: 582  IINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVE 641
            ++NNYF IG+DA I+  F+  R++HP ++NSR+KNK WY   GT E    + +KL E V 
Sbjct: 857  VMNNYFGIGLDAKISLDFNTRRDEHPGQYNSRLKNKMWYGLLGTKELLQRSYRKLEERVH 916

Query: 642  IECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAK 701
            +ECDG  I L N  L+GI +LNI S  GG N W               GS+  TT     
Sbjct: 917  LECDGETISLPN--LQGIVVLNITSYAGGINFW---------------GSNTATT----- 954

Query: 702  ELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRT--SKSLPMQID 759
              ++ +  + D  LEVV + G+++M      +     R+AQC  V+I     + +P+Q+D
Sbjct: 955  --EYEAPAIDDGKLEVVAIFGSVQMAMSRI-INLHHHRIAQCHEVMITIDGEEGIPVQVD 1011

Query: 760  GEPWMQTP 767
            GE W+Q P
Sbjct: 1012 GEAWIQRP 1019


>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
          Length = 671

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 51/196 (26%), Positives = 80/196 (40%), Gaps = 29/196 (14%)

Query: 236 ENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSC- 294
           + NV +   H +  + F +P +C+ C + + G GKQG  C  C + VH+RC      SC 
Sbjct: 28  QKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCP 87

Query: 295 ------IKTYVKSKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGL--TGLHCVWCQITL 346
                      +SK    + H Y    + PT CD C   +    GL   G+ C  C + +
Sbjct: 88  GADKGPASDDPRSKHKFKI-HTY----SSPTFCDHCGSLL---YGLIHQGMKCDTCMMNV 139

Query: 347 HNKCASHLKPECDCGP--------LKDHILPPTTICPV----VLQTLPTSGVSVPEERQS 394
           H +C  ++   C            ++ HI     I  V     L  +  +G+S P  +  
Sbjct: 140 HKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLK 199

Query: 395 TVKKEKSGSQQPNKVI 410
            +   KS S+Q  K I
Sbjct: 200 LIPDPKSESKQKTKTI 215


>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
          Length = 673

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 51/196 (26%), Positives = 80/196 (40%), Gaps = 29/196 (14%)

Query: 236 ENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSC- 294
           + NV +   H +  + F +P +C+ C + + G GKQG  C  C + VH+RC      SC 
Sbjct: 28  QKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCP 87

Query: 295 ------IKTYVKSKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGL--TGLHCVWCQITL 346
                      +SK    + H Y    + PT CD C   +    GL   G+ C  C + +
Sbjct: 88  GADKGPASDDPRSKHKFKI-HTY----SSPTFCDHCGSLL---YGLIHQGMKCDTCMMNV 139

Query: 347 HNKCASHLKPECDCGP--------LKDHILPPTTICPV----VLQTLPTSGVSVPEERQS 394
           H +C  ++   C            ++ HI     I  V     L  +  +G+S P  +  
Sbjct: 140 HKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLK 199

Query: 395 TVKKEKSGSQQPNKVI 410
            +   KS S+Q  K I
Sbjct: 200 LIPDPKSESKQKTKTI 215


>gi|13384594 protein kinase C, gamma [Homo sapiens]
          Length = 697

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 34/122 (27%), Positives = 55/122 (45%), Gaps = 15/122 (12%)

Query: 245 HVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSC------IKTY 298
           H +  + F +P +C+ C + + G+GKQGL C  C + VH RC       C       +T 
Sbjct: 36  HKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTD 95

Query: 299 VKSKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLT--GLHCVWCQITLHNKCASHLKP 356
               ++   +H Y    + PT CD C   +    GL   G+ C  C++ +H +C   +  
Sbjct: 96  DPRNKHKFRLHSY----SSPTFCDHCGSLL---YGLVHQGMKCSCCEMNVHRRCVRSVPS 148

Query: 357 EC 358
            C
Sbjct: 149 LC 150



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 28/85 (32%), Positives = 43/85 (50%), Gaps = 7/85 (8%)

Query: 244 QHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKR 303
           +H +RL  ++ P +C+ C ++L G+  QG+ CS C+  VH RCV   P  C         
Sbjct: 100 KHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLC------GVD 153

Query: 304 NTDVMHHYWVEGNCPTKCDKCHKTV 328
           +T+      +E   PT  D+ H TV
Sbjct: 154 HTERRGRLQLEIRAPT-ADEIHVTV 177


>gi|47157325 protein kinase C, delta [Homo sapiens]
          Length = 676

 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 35/125 (28%), Positives = 57/125 (45%), Gaps = 14/125 (11%)

Query: 245 HVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKT------- 297
           H +    F +P +C++C + + G+ KQG  C  C   +H++C+ +    C  T       
Sbjct: 159 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDT 218

Query: 298 -YVKSKRNTDVMHHYWVEG-NCPTKCDKCHKTVKCYQGLT--GLHCVWCQITLHNKCASH 353
            + K + N D+ H + V     PT CD C   +    GL   GL C  C + +H+KC   
Sbjct: 219 IFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLL---WGLVKQGLKCEDCGMNVHHKCREK 275

Query: 354 LKPEC 358
           +   C
Sbjct: 276 VANLC 280



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 17/53 (32%), Positives = 29/53 (54%)

Query: 242 DGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSC 294
           D  H +++ ++  P +C+ C ++L G+ KQGL C  C   VH +C  +    C
Sbjct: 228 DMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLC 280


>gi|31377782 protein kinase C, delta [Homo sapiens]
          Length = 676

 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 35/125 (28%), Positives = 57/125 (45%), Gaps = 14/125 (11%)

Query: 245 HVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKT------- 297
           H +    F +P +C++C + + G+ KQG  C  C   +H++C+ +    C  T       
Sbjct: 159 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDT 218

Query: 298 -YVKSKRNTDVMHHYWVEG-NCPTKCDKCHKTVKCYQGLT--GLHCVWCQITLHNKCASH 353
            + K + N D+ H + V     PT CD C   +    GL   GL C  C + +H+KC   
Sbjct: 219 IFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLL---WGLVKQGLKCEDCGMNVHHKCREK 275

Query: 354 LKPEC 358
           +   C
Sbjct: 276 VANLC 280



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 17/53 (32%), Positives = 29/53 (54%)

Query: 242 DGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSC 294
           D  H +++ ++  P +C+ C ++L G+ KQGL C  C   VH +C  +    C
Sbjct: 228 DMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLC 280


>gi|4506067 protein kinase C, alpha [Homo sapiens]
          Length = 672

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 48/195 (24%), Positives = 77/195 (39%), Gaps = 27/195 (13%)

Query: 236 ENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSC- 294
           + NV +   H +  + F +P +C+ C + + G GKQG  C  C + VH+RC      SC 
Sbjct: 28  QKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCP 87

Query: 295 -----IKTYVKSKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGL--TGLHCVWCQITLH 347
                  T     ++   +H Y      PT CD C   +    GL   G+ C  C + +H
Sbjct: 88  GADKGPDTDDPRSKHKFKIHTY----GSPTFCDHCGSLL---YGLIHQGMKCDTCDMNVH 140

Query: 348 NKCASHLKPECDC------------GPLKDHILPPTTICPVVLQTLPTSGVSVPEERQST 395
            +C  ++   C                + D  L  T      L  +  +G+S P  +   
Sbjct: 141 KQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKL 200

Query: 396 VKKEKSGSQQPNKVI 410
           +   K+ S+Q  K I
Sbjct: 201 IPDPKNESKQKTKTI 215


>gi|4885563 protein kinase C, epsilon [Homo sapiens]
          Length = 737

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 37/126 (29%), Positives = 58/126 (46%), Gaps = 15/126 (11%)

Query: 245 HVWRLKHFNKPAYCNLCLNMLIGV-GKQGLCCSFCKYTVHERCVARAPPSC-------IK 296
           H +   +  +P YC+ C + + GV GKQG  C  C   VH+RC       C         
Sbjct: 170 HKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETP 229

Query: 297 TYVKSKR-NTDVMHHYWVEG-NCPTKCDKCHKTVKCYQGL--TGLHCVWCQITLHNKCAS 352
             V S+R + ++ H + +     PT CD C   +    GL   GL C  C++ +H +C +
Sbjct: 230 DQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLL---WGLLRQGLQCKVCKMNVHRRCET 286

Query: 353 HLKPEC 358
           ++ P C
Sbjct: 287 NVAPNC 292


>gi|40254415 guanylate cyclase activator 1A (retina) [Homo sapiens]
          Length = 201

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 33/90 (36%), Positives = 50/90 (55%), Gaps = 1/90 (1%)

Query: 133 IHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYLEWDV 192
           I   + V  LSL+ +G+ E KL + F+LYD DGNG +D  EL  II  +  +    +  +
Sbjct: 71  IDFMEYVAALSLVLKGKVEQKLRWYFKLYDVDGNGCIDRDELLTIIQAIRAINPCSDTTM 130

Query: 193 TELNPILHEMMEEIDYDHDGTVSLEEWIQG 222
           T        +  +ID + DG +SLEE+I+G
Sbjct: 131 T-AEEFTDTVFSKIDVNGDGELSLEEFIEG 159


>gi|19913446 hippocalcin [Homo sapiens]
          Length = 193

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 34/111 (30%), Positives = 61/111 (54%), Gaps = 3/111 (2%)

Query: 126 NTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQMMH-V 184
           +T S   I  ++ +  LS+  RGR E KL + F +YD DGNG++   E+  I+  +   V
Sbjct: 73  DTNSDGTIDFREFIIALSVTSRGRLEQKLMWAFSMYDLDGNGYISREEMLEIVQAIYKMV 132

Query: 185 AEYLEWDVTELNP--ILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLL 233
           +  ++    E  P     ++  ++D ++DG +SLEE+I+G  +   ++ LL
Sbjct: 133 SSVMKMPEDESTPEKRTEKIFRQMDTNNDGKLSLEEFIRGAKSDPSIVRLL 183


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,078,201
Number of Sequences: 37866
Number of extensions: 1639601
Number of successful extensions: 5981
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 141
Number of HSP's successfully gapped in prelim test: 127
Number of HSP's that attempted gapping in prelim test: 5272
Number of HSP's gapped (non-prelim): 589
length of query: 773
length of database: 18,247,518
effective HSP length: 110
effective length of query: 663
effective length of database: 14,082,258
effective search space: 9336537054
effective search space used: 9336537054
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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