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Search of human proteins with 22027634
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo
sapiens]
(773 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo sapiens] 1613 0.0
gi|22027632 diacylglycerol kinase, beta isoform 1 [Homo sapiens] 1607 0.0
gi|124256476 diacylglycerol kinase gamma isoform 1 [Homo sapiens] 976 0.0
gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo sapiens] 927 0.0
gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 850 0.0
gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 850 0.0
gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 850 0.0
gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 850 0.0
gi|124256482 diacylglycerol kinase gamma isoform 3 [Homo sapiens] 823 0.0
gi|4758156 diacylglycerol kinase, iota [Homo sapiens] 293 3e-79
gi|41872507 diacylglycerol kinase zeta isoform 2 [Homo sapiens] 285 9e-77
gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens] 285 9e-77
gi|157688564 diacylglycerol kinase zeta isoform 4 [Homo sapiens] 285 1e-76
gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens] 285 1e-76
gi|4503313 diacylglycerol kinase epsilon [Homo sapiens] 273 6e-73
gi|40806175 diacylglycerol kinase, theta [Homo sapiens] 254 3e-67
gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo ... 210 5e-54
gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo ... 210 5e-54
gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens] 207 4e-53
gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens] 207 4e-53
gi|62000702 diacylglycerol kinase kappa [Homo sapiens] 183 6e-46
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 62 3e-09
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 62 3e-09
gi|13384594 protein kinase C, gamma [Homo sapiens] 61 3e-09
gi|47157325 protein kinase C, delta [Homo sapiens] 61 5e-09
gi|31377782 protein kinase C, delta [Homo sapiens] 61 5e-09
gi|4506067 protein kinase C, alpha [Homo sapiens] 59 1e-08
gi|4885563 protein kinase C, epsilon [Homo sapiens] 58 3e-08
gi|40254415 guanylate cyclase activator 1A (retina) [Homo sapiens] 58 3e-08
gi|19913446 hippocalcin [Homo sapiens] 58 3e-08
>gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo sapiens]
Length = 773
Score = 1613 bits (4177), Expect = 0.0
Identities = 773/773 (100%), Positives = 773/773 (100%)
Query: 1 MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDF 60
MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDF
Sbjct: 1 MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDF 60
Query: 61 EGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPR 120
EGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPR
Sbjct: 61 EGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPR 120
Query: 121 TTSPANTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQ 180
TTSPANTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQ
Sbjct: 121 TTSPANTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQ 180
Query: 181 MMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVK 240
MMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVK
Sbjct: 181 MMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVK 240
Query: 241 DDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVK 300
DDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVK
Sbjct: 241 DDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVK 300
Query: 301 SKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDC 360
SKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDC
Sbjct: 301 SKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDC 360
Query: 361 GPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANS 420
GPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANS
Sbjct: 361 GPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANS 420
Query: 421 VTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGL 480
VTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGL
Sbjct: 421 VTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGL 480
Query: 481 NFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYE 540
NFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYE
Sbjct: 481 NFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYE 540
Query: 541 GENLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFH 600
GENLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFH
Sbjct: 541 GENLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFH 600
Query: 601 IMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIA 660
IMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIA
Sbjct: 601 IMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIA 660
Query: 661 ILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGL 720
ILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGL
Sbjct: 661 ILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGL 720
Query: 721 EGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTVSTE 773
EGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTVSTE
Sbjct: 721 EGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTVSTE 773
>gi|22027632 diacylglycerol kinase, beta isoform 1 [Homo sapiens]
Length = 804
Score = 1607 bits (4162), Expect = 0.0
Identities = 769/770 (99%), Positives = 770/770 (100%)
Query: 1 MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDF 60
MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDF
Sbjct: 1 MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDF 60
Query: 61 EGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPR 120
EGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPR
Sbjct: 61 EGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPR 120
Query: 121 TTSPANTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQ 180
TTSPANTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQ
Sbjct: 121 TTSPANTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQ 180
Query: 181 MMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVK 240
MMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVK
Sbjct: 181 MMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVK 240
Query: 241 DDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVK 300
DDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVK
Sbjct: 241 DDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVK 300
Query: 301 SKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDC 360
SKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDC
Sbjct: 301 SKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDC 360
Query: 361 GPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANS 420
GPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANS
Sbjct: 361 GPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANS 420
Query: 421 VTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGL 480
VTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGL
Sbjct: 421 VTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGL 480
Query: 481 NFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYE 540
NFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYE
Sbjct: 481 NFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYE 540
Query: 541 GENLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFH 600
GENLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFH
Sbjct: 541 GENLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFH 600
Query: 601 IMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIA 660
IMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIA
Sbjct: 601 IMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIA 660
Query: 661 ILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGL 720
ILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGL
Sbjct: 661 ILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGL 720
Query: 721 EGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTV 770
EGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCT+
Sbjct: 721 EGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTI 770
>gi|124256476 diacylglycerol kinase gamma isoform 1 [Homo sapiens]
Length = 791
Score = 976 bits (2524), Expect = 0.0
Identities = 474/802 (59%), Positives = 575/802 (71%), Gaps = 79/802 (9%)
Query: 4 QEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGF 63
+E+W L+P EF QLQKY+EYS+KK+KD L EF+ G L +Y+P ++ I ++ F
Sbjct: 3 EERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDP-------HEPISYDVF 55
Query: 64 KLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTS 123
KLFM+ +LE +LP + HLF++FS K H + ++ A S + T
Sbjct: 56 KLFMRAYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATK 115
Query: 124 PANTCSPE----------------------------------VIHLKDIVCYLSLLERGR 149
C+P+ V++LKD+VCYLSLLE GR
Sbjct: 116 ADEACAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGR 175
Query: 150 PEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYLEWDVTELNPILHEMMEEIDYD 209
P+DKLEFMFRLYD+D NG LD +E++ I++QM+H+A+YLEWD TEL PIL EM++ +DYD
Sbjct: 176 PQDKLEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYD 235
Query: 210 HDGTVSLEEWIQGGMTTIPLLVLLGLENN-VKDDGQHVWRLKHFNKPAYCNLCLNMLIGV 268
DG VSL+EW+ GGMTTIPLLVLLG++++ K DG+H W +KHF KP YCN C ML+GV
Sbjct: 236 RDGFVSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGV 295
Query: 269 GKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVMHHYWVEGNCPTKCDKCHKTV 328
KQGLCC++CKYTVHERCV+R P C+KTY K+KR+ +VM H WVEGN KCD+CHK++
Sbjct: 296 RKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSI 355
Query: 329 KCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSV 388
KCYQ +T HCVWC++T H KC L CD G L+DHIL PT+ICP+
Sbjct: 356 KCYQSVTARHCVWCRMTFHRKC--ELSTLCDGGELRDHILLPTSICPIT----------- 402
Query: 389 PEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSG 448
+++ G + V K ++ ++ P PGTHPLLV VNPKSG
Sbjct: 403 ---------RDRPGEKSDGCVSAKGELVMQ---------YKIIPTPGTHPLLVLVNPKSG 444
Query: 449 GKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIE 508
G+QGERI RKF YLLNP+QV++L GP PGLNFFRD PDFRVLACGGDGTVGW+LDCI+
Sbjct: 445 GRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDFRVLACGGDGTVGWILDCID 504
Query: 509 KANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIP 568
KAN KHPPVA+LPLGTGNDLARCLRWGGGYEG +L KILKDIE S +MLDRW EVIP
Sbjct: 505 KANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIP 564
Query: 569 NDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSET 628
++ E GD VPYSI+NNYFSIGVDASIAHRFH+MREKHPEKFNSRMKNK WYFEFGTSET
Sbjct: 565 REEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSET 624
Query: 629 FSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEK 688
F+ATCKKLH+ +E+ECDGV +DL NI LEGIAILNIPSM+GG+NLWGE+KK R+ R +
Sbjct: 625 FAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESR 684
Query: 689 KGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVI 748
KG VTD KELKF QDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQC+ V I
Sbjct: 685 KG------VTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTI 738
Query: 749 RTSKSLPMQIDGEPWMQTPCTV 770
RT+K LPMQ+DGEPWMQ CT+
Sbjct: 739 RTNKLLPMQVDGEPWMQPCCTI 760
>gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo sapiens]
Length = 766
Score = 927 bits (2397), Expect = 0.0
Identities = 458/802 (57%), Positives = 556/802 (69%), Gaps = 104/802 (12%)
Query: 4 QEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGF 63
+E+W L+P EF QLQKY+EYS+KK+KD L EF+ G L +Y+P ++ I ++ F
Sbjct: 3 EERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDP-------HEPISYDVF 55
Query: 64 KLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTS 123
KLFM+ +LE +LP + HLF++FS K H + ++ A S + T
Sbjct: 56 KLFMRAYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATK 115
Query: 124 PANTCSPE----------------------------------VIHLKDIVCYLSLLERGR 149
C+P+ V++LKD+VCYLSLLE GR
Sbjct: 116 ADEACAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGR 175
Query: 150 PEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYLEWDVTELNPILHEMMEEIDYD 209
P+DKLEFMFRLYD+D NG LD +E++ I++QM+H+A+YLEWD TEL PIL EM++ +DYD
Sbjct: 176 PQDKLEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYD 235
Query: 210 HDGTVSLEEWIQGGMTTIPLLVLLGLENN-VKDDGQHVWRLKHFNKPAYCNLCLNMLIGV 268
DG VSL+EW+ GGMTTIPLLVLLG++++ K DG+H W +KHF KP YCN C ML+GV
Sbjct: 236 RDGFVSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGV 295
Query: 269 GKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVMHHYWVEGNCPTKCDKCHKTV 328
KQGLCC++CKYTVHERCV+R P C+KTY K+KR+ +VM H WVEGN KCD+CHK++
Sbjct: 296 RKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSI 355
Query: 329 KCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSV 388
KCYQ +T HCVWC++T H KC L CD G L+DHIL PT+ICP+
Sbjct: 356 KCYQSVTARHCVWCRMTFHRKC--ELSTLCDGGELRDHILLPTSICPIT----------- 402
Query: 389 PEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSG 448
+++ G + V K ++ ++ P PGTHPLLV VNPKSG
Sbjct: 403 ---------RDRPGEKSDGCVSAKGELVMQ---------YKIIPTPGTHPLLVLVNPKSG 444
Query: 449 GKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIE 508
G+QGER LNFFRD PDFRVLACGGDGTVGW+LDCI+
Sbjct: 445 GRQGER-------------------------LNFFRDTPDFRVLACGGDGTVGWILDCID 479
Query: 509 KANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIP 568
KAN KHPPVA+LPLGTGNDLARCLRWGGGYEG +L KILKDIE S +MLDRW EVIP
Sbjct: 480 KANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIP 539
Query: 569 NDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSET 628
++ E GD VPYSI+NNYFSIGVDASIAHRFH+MREKHPEKFNSRMKNK WYFEFGTSET
Sbjct: 540 REEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSET 599
Query: 629 FSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEK 688
F+ATCKKLH+ +E+ECDGV +DL NI LEGIAILNIPSM+GG+NLWGE+KK R+ R +
Sbjct: 600 FAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESR 659
Query: 689 KGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVI 748
KG VTD KELKF QDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQC+ V I
Sbjct: 660 KG------VTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTI 713
Query: 749 RTSKSLPMQIDGEPWMQTPCTV 770
RT+K LPMQ+DGEPWMQ CT+
Sbjct: 714 RTNKLLPMQVDGEPWMQPCCTI 735
>gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 850 bits (2197), Expect = 0.0
Identities = 429/767 (55%), Positives = 536/767 (69%), Gaps = 71/767 (9%)
Query: 10 LSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGFKLFMKT 69
+SPS+F+QLQKY EYSTKK+ DVL+ F +G +AKY + I +EGF+ F+K
Sbjct: 8 ISPSDFAQLQKYMEYSTKKVSDVLKLFE-DGEMAKY-------VQGDAIGYEGFQQFLKI 59
Query: 70 FLEAE-LPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTSPANTC 128
+LE + +P + LF SF G +N+ +T
Sbjct: 60 YLEVDNVPRHLSLALFQSFET------------------GHCLNETNVTK---------- 91
Query: 129 SPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYL 188
+V+ L D+ CY SLLE GRPEDKLEF F+LYDTD NG LDSSE++ II QMM VAEYL
Sbjct: 92 --DVVCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYL 149
Query: 189 EWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWR 248
+WDV+EL PIL EMM+EIDYD G+VS EW++ G TT+PLLVLLGLE +KDDGQH+WR
Sbjct: 150 DWDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTVPLLVLLGLEMTLKDDGQHMWR 209
Query: 249 LKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVM 308
K F +P YCNLC + IG+GKQGL C+ CKYTVH++C +A P + TY KS+++ V
Sbjct: 210 PKRFPRPVYCNLCESS-IGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQ 268
Query: 309 HHYWVEGNCPT-KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHI 367
H WV G C + +CD+C K ++ Y LTGLHCVWC + +H+ C + ECDCG L+DHI
Sbjct: 269 SHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHI 328
Query: 368 LPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQG 427
LPP++I P VL + P ++ S+ K +D + + ++ +D
Sbjct: 329 LPPSSIYPSVLASGP----------------DRKNSKTSQKTMDDLNLSTSEALRID--- 369
Query: 428 LQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVP 487
PVP THPLLVFVNPKSGGKQG+R+ KFQY+LNPRQV++L +GP GL F+DVP
Sbjct: 370 ----PVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVP 425
Query: 488 DFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKI 547
D R+L CGGDGTVGW+L+ I+KAN+ PPVA+LPLGTGNDLARCLRWGGGYEG+NL KI
Sbjct: 426 DSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKI 485
Query: 548 LKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHP 607
LKD+E S + +DRW EVIP +EK DPVP+ IINNYFSIGVDASIAHRFHIMREK+P
Sbjct: 486 LKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYP 545
Query: 608 EKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSM 667
EKFNSRMKNK WYFEF TSE+ +TCKKL ES+ +E G +DL N+SLEGIA+LNIPSM
Sbjct: 546 EKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSM 605
Query: 668 HGGSNLWGESKKRRSHRRI----EKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGA 723
HGGSNLWG++ RR H I + G+ + +TD LK DLSD+ LEVVGLEGA
Sbjct: 606 HGGSNLWGDT--RRPHGDIYGINQALGATAK-VITDPDILKTCVPDLSDKRLEVVGLEGA 662
Query: 724 MEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTV 770
+EMGQIYT LK+AGRRLA+CS + T+K+LPMQIDGEPWMQTPCT+
Sbjct: 663 IEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTI 709
>gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 850 bits (2197), Expect = 0.0
Identities = 429/767 (55%), Positives = 536/767 (69%), Gaps = 71/767 (9%)
Query: 10 LSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGFKLFMKT 69
+SPS+F+QLQKY EYSTKK+ DVL+ F +G +AKY + I +EGF+ F+K
Sbjct: 8 ISPSDFAQLQKYMEYSTKKVSDVLKLFE-DGEMAKY-------VQGDAIGYEGFQQFLKI 59
Query: 70 FLEAE-LPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTSPANTC 128
+LE + +P + LF SF G +N+ +T
Sbjct: 60 YLEVDNVPRHLSLALFQSFET------------------GHCLNETNVTK---------- 91
Query: 129 SPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYL 188
+V+ L D+ CY SLLE GRPEDKLEF F+LYDTD NG LDSSE++ II QMM VAEYL
Sbjct: 92 --DVVCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYL 149
Query: 189 EWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWR 248
+WDV+EL PIL EMM+EIDYD G+VS EW++ G TT+PLLVLLGLE +KDDGQH+WR
Sbjct: 150 DWDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTVPLLVLLGLEMTLKDDGQHMWR 209
Query: 249 LKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVM 308
K F +P YCNLC + IG+GKQGL C+ CKYTVH++C +A P + TY KS+++ V
Sbjct: 210 PKRFPRPVYCNLCESS-IGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQ 268
Query: 309 HHYWVEGNCPT-KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHI 367
H WV G C + +CD+C K ++ Y LTGLHCVWC + +H+ C + ECDCG L+DHI
Sbjct: 269 SHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHI 328
Query: 368 LPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQG 427
LPP++I P VL + P ++ S+ K +D + + ++ +D
Sbjct: 329 LPPSSIYPSVLASGP----------------DRKNSKTSQKTMDDLNLSTSEALRID--- 369
Query: 428 LQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVP 487
PVP THPLLVFVNPKSGGKQG+R+ KFQY+LNPRQV++L +GP GL F+DVP
Sbjct: 370 ----PVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVP 425
Query: 488 DFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKI 547
D R+L CGGDGTVGW+L+ I+KAN+ PPVA+LPLGTGNDLARCLRWGGGYEG+NL KI
Sbjct: 426 DSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKI 485
Query: 548 LKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHP 607
LKD+E S + +DRW EVIP +EK DPVP+ IINNYFSIGVDASIAHRFHIMREK+P
Sbjct: 486 LKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYP 545
Query: 608 EKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSM 667
EKFNSRMKNK WYFEF TSE+ +TCKKL ES+ +E G +DL N+SLEGIA+LNIPSM
Sbjct: 546 EKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSM 605
Query: 668 HGGSNLWGESKKRRSHRRI----EKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGA 723
HGGSNLWG++ RR H I + G+ + +TD LK DLSD+ LEVVGLEGA
Sbjct: 606 HGGSNLWGDT--RRPHGDIYGINQALGATAK-VITDPDILKTCVPDLSDKRLEVVGLEGA 662
Query: 724 MEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTV 770
+EMGQIYT LK+AGRRLA+CS + T+K+LPMQIDGEPWMQTPCT+
Sbjct: 663 IEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTI 709
>gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 850 bits (2197), Expect = 0.0
Identities = 429/767 (55%), Positives = 536/767 (69%), Gaps = 71/767 (9%)
Query: 10 LSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGFKLFMKT 69
+SPS+F+QLQKY EYSTKK+ DVL+ F +G +AKY + I +EGF+ F+K
Sbjct: 8 ISPSDFAQLQKYMEYSTKKVSDVLKLFE-DGEMAKY-------VQGDAIGYEGFQQFLKI 59
Query: 70 FLEAE-LPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTSPANTC 128
+LE + +P + LF SF G +N+ +T
Sbjct: 60 YLEVDNVPRHLSLALFQSFET------------------GHCLNETNVTK---------- 91
Query: 129 SPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYL 188
+V+ L D+ CY SLLE GRPEDKLEF F+LYDTD NG LDSSE++ II QMM VAEYL
Sbjct: 92 --DVVCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYL 149
Query: 189 EWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWR 248
+WDV+EL PIL EMM+EIDYD G+VS EW++ G TT+PLLVLLGLE +KDDGQH+WR
Sbjct: 150 DWDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTVPLLVLLGLEMTLKDDGQHMWR 209
Query: 249 LKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVM 308
K F +P YCNLC + IG+GKQGL C+ CKYTVH++C +A P + TY KS+++ V
Sbjct: 210 PKRFPRPVYCNLCESS-IGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQ 268
Query: 309 HHYWVEGNCPT-KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHI 367
H WV G C + +CD+C K ++ Y LTGLHCVWC + +H+ C + ECDCG L+DHI
Sbjct: 269 SHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHI 328
Query: 368 LPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQG 427
LPP++I P VL + P ++ S+ K +D + + ++ +D
Sbjct: 329 LPPSSIYPSVLASGP----------------DRKNSKTSQKTMDDLNLSTSEALRID--- 369
Query: 428 LQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVP 487
PVP THPLLVFVNPKSGGKQG+R+ KFQY+LNPRQV++L +GP GL F+DVP
Sbjct: 370 ----PVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVP 425
Query: 488 DFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKI 547
D R+L CGGDGTVGW+L+ I+KAN+ PPVA+LPLGTGNDLARCLRWGGGYEG+NL KI
Sbjct: 426 DSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKI 485
Query: 548 LKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHP 607
LKD+E S + +DRW EVIP +EK DPVP+ IINNYFSIGVDASIAHRFHIMREK+P
Sbjct: 486 LKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYP 545
Query: 608 EKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSM 667
EKFNSRMKNK WYFEF TSE+ +TCKKL ES+ +E G +DL N+SLEGIA+LNIPSM
Sbjct: 546 EKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSM 605
Query: 668 HGGSNLWGESKKRRSHRRI----EKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGA 723
HGGSNLWG++ RR H I + G+ + +TD LK DLSD+ LEVVGLEGA
Sbjct: 606 HGGSNLWGDT--RRPHGDIYGINQALGATAK-VITDPDILKTCVPDLSDKRLEVVGLEGA 662
Query: 724 MEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTV 770
+EMGQIYT LK+AGRRLA+CS + T+K+LPMQIDGEPWMQTPCT+
Sbjct: 663 IEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTI 709
>gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 850 bits (2197), Expect = 0.0
Identities = 429/767 (55%), Positives = 536/767 (69%), Gaps = 71/767 (9%)
Query: 10 LSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGFKLFMKT 69
+SPS+F+QLQKY EYSTKK+ DVL+ F +G +AKY + I +EGF+ F+K
Sbjct: 8 ISPSDFAQLQKYMEYSTKKVSDVLKLFE-DGEMAKY-------VQGDAIGYEGFQQFLKI 59
Query: 70 FLEAE-LPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTSPANTC 128
+LE + +P + LF SF G +N+ +T
Sbjct: 60 YLEVDNVPRHLSLALFQSFET------------------GHCLNETNVTK---------- 91
Query: 129 SPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYL 188
+V+ L D+ CY SLLE GRPEDKLEF F+LYDTD NG LDSSE++ II QMM VAEYL
Sbjct: 92 --DVVCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYL 149
Query: 189 EWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWR 248
+WDV+EL PIL EMM+EIDYD G+VS EW++ G TT+PLLVLLGLE +KDDGQH+WR
Sbjct: 150 DWDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTVPLLVLLGLEMTLKDDGQHMWR 209
Query: 249 LKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVM 308
K F +P YCNLC + IG+GKQGL C+ CKYTVH++C +A P + TY KS+++ V
Sbjct: 210 PKRFPRPVYCNLCESS-IGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQ 268
Query: 309 HHYWVEGNCPT-KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHI 367
H WV G C + +CD+C K ++ Y LTGLHCVWC + +H+ C + ECDCG L+DHI
Sbjct: 269 SHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHI 328
Query: 368 LPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQG 427
LPP++I P VL + P ++ S+ K +D + + ++ +D
Sbjct: 329 LPPSSIYPSVLASGP----------------DRKNSKTSQKTMDDLNLSTSEALRID--- 369
Query: 428 LQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVP 487
PVP THPLLVFVNPKSGGKQG+R+ KFQY+LNPRQV++L +GP GL F+DVP
Sbjct: 370 ----PVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVP 425
Query: 488 DFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKI 547
D R+L CGGDGTVGW+L+ I+KAN+ PPVA+LPLGTGNDLARCLRWGGGYEG+NL KI
Sbjct: 426 DSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKI 485
Query: 548 LKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHP 607
LKD+E S + +DRW EVIP +EK DPVP+ IINNYFSIGVDASIAHRFHIMREK+P
Sbjct: 486 LKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYP 545
Query: 608 EKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSM 667
EKFNSRMKNK WYFEF TSE+ +TCKKL ES+ +E G +DL N+SLEGIA+LNIPSM
Sbjct: 546 EKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSM 605
Query: 668 HGGSNLWGESKKRRSHRRI----EKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGA 723
HGGSNLWG++ RR H I + G+ + +TD LK DLSD+ LEVVGLEGA
Sbjct: 606 HGGSNLWGDT--RRPHGDIYGINQALGATAK-VITDPDILKTCVPDLSDKRLEVVGLEGA 662
Query: 724 MEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTV 770
+EMGQIYT LK+AGRRLA+CS + T+K+LPMQIDGEPWMQTPCT+
Sbjct: 663 IEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTI 709
>gi|124256482 diacylglycerol kinase gamma isoform 3 [Homo sapiens]
Length = 752
Score = 823 bits (2126), Expect = 0.0
Identities = 432/802 (53%), Positives = 524/802 (65%), Gaps = 118/802 (14%)
Query: 4 QEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGF 63
+E+W L+P EF QLQKY+EYS+KK+KD L EF+ G L +Y+P ++ I ++ F
Sbjct: 3 EERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDP-------HEPISYDVF 55
Query: 64 KLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTS 123
KLFM+ +LE +LP + HLF++FS K H + ++ A S + T
Sbjct: 56 KLFMRAYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATK 115
Query: 124 PANTCSPE----------------------------------VIHLKDIVCYLSLLERGR 149
C+P+ V++LKD+VCYLSLLE GR
Sbjct: 116 ADEACAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGR 175
Query: 150 PEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYLEWDVTELNPILHEMMEEIDYD 209
P+DKLEFMFRLYD+D NG LD +E++ I++QM+H+A+YLEWD TEL PIL EM++ +DYD
Sbjct: 176 PQDKLEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYD 235
Query: 210 HDGTVSLEEWIQGGMTTIPLLVLLGLENN-VKDDGQHVWRLKHFNKPAYCNLCLNMLIGV 268
DG VSL+EW+ GGMTTIPLLVLLG++++ K DG+H W +KHF KP Y
Sbjct: 236 RDGFVSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTY----------- 284
Query: 269 GKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVMHHYWVEGNCPTKCDKCHKTV 328
C+FC H + TY K +H V N P C K +
Sbjct: 285 ------CNFC----HIMLMGVRKQGLCCTYCKY-----TVHERCVSRNIPG-CVKTYSKA 328
Query: 329 KCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSV 388
K +G H KC L CD G L+DHIL PT+ICP+
Sbjct: 329 K----RSG--------EFHRKC--ELSTLCDGGELRDHILLPTSICPIT----------- 363
Query: 389 PEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSG 448
+++ G + V K ++ ++ P PGTHPLLV VNPKSG
Sbjct: 364 ---------RDRPGEKSDGCVSAKGELVMQ---------YKIIPTPGTHPLLVLVNPKSG 405
Query: 449 GKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIE 508
G+QGERI RKF YLLNP+QV++L GP PGLNFFRD PDFRVLACGGDGTVGW+LDCI+
Sbjct: 406 GRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDFRVLACGGDGTVGWILDCID 465
Query: 509 KANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIP 568
KAN KHPPVA+LPLGTGNDLARCLRWGGGYEG +L KILKDIE S +MLDRW EVIP
Sbjct: 466 KANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIP 525
Query: 569 NDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSET 628
++ E GD VPYSI+NNYFSIGVDASIAHRFH+MREKHPEKFNSRMKNK WYFEFGTSET
Sbjct: 526 REEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSET 585
Query: 629 FSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEK 688
F+ATCKKLH+ +E+ECDGV +DL NI LEGIAILNIPSM+GG+NLWGE+KK R+ R +
Sbjct: 586 FAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESR 645
Query: 689 KGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVI 748
KG VTD KELKF QDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQC+ V I
Sbjct: 646 KG------VTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTI 699
Query: 749 RTSKSLPMQIDGEPWMQTPCTV 770
RT+K LPMQ+DGEPWMQ CT+
Sbjct: 700 RTNKLLPMQVDGEPWMQPCCTI 721
>gi|4758156 diacylglycerol kinase, iota [Homo sapiens]
Length = 1065
Score = 293 bits (751), Expect = 3e-79
Identities = 195/584 (33%), Positives = 275/584 (47%), Gaps = 80/584 (13%)
Query: 220 IQGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNLCL----NMLIGVGKQGLC- 274
+ G P L EN V +G+H+W + + +LC N + K L
Sbjct: 155 VANGPAKEPRATLDWSENAV--NGEHLWLETNVSG----DLCYLGEENCQVRFAKSALRR 208
Query: 275 -CSFCKYTVHERCVA-------RAPPSCIKTYVKSKRNTDVMHHYWVEGNCPTKCDKCHK 326
C+ CK VH C+ R P+ + +S R V HH+ KC +C K
Sbjct: 209 KCAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGK 268
Query: 327 TVKCY-----QGLTGLHCVWCQITLHNKCAS----HLKPECDCGPLKDHILPPTTICPVV 377
+ + + + C WC+ HNK H++ C G I+PPT I V
Sbjct: 269 GFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVK 328
Query: 378 LQTLPTSGVSVPEERQSTVKK-EKSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPV--P 434
+ ++R S +K K G +Q NK G+ + P+ P
Sbjct: 329 KPQNSLKASNRKKKRTSFKRKASKRGMEQENK----------------GRPFVIKPISSP 372
Query: 435 GTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLAC 494
PLLVFVNPKSGG QG ++ + F + LNPRQV+ LS GP L +R VP+ R+LAC
Sbjct: 373 LMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILAC 432
Query: 495 GGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENS 554
GGDGTVGW+L +++ + PPV +LPLGTGNDLAR L WGGGY E + KIL +E+
Sbjct: 433 GGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDG 492
Query: 555 TEIMLDRWKFEV-----IPNDKDEKG-DPVPYSIINNYFSIGVDASIAHRFHIMREKHPE 608
T + LDRW V +P ++ E G +P ++ NNYFS+G DA + FH RE +PE
Sbjct: 493 TVVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPE 552
Query: 609 KFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQI--DLINISLEGIAILNIPS 666
KFNSR +NK +Y S+ + + L + V++ CDG + + + + I LNIP
Sbjct: 553 KFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQELKFQCIVFLNIPR 612
Query: 667 MHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGAMEM 726
G+ WG F Q D +EV+G A +
Sbjct: 613 YCAGTMPWGNPGDHHD----------------------FEPQRHDDGYIEVIGFTMA-SL 649
Query: 727 GQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTV 770
+ G G RL QC V++ T KS+PMQ+DGEP P +
Sbjct: 650 AALQVG--GHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMI 691
>gi|41872507 diacylglycerol kinase zeta isoform 2 [Homo sapiens]
Length = 929
Score = 285 bits (730), Expect = 9e-77
Identities = 182/554 (32%), Positives = 267/554 (48%), Gaps = 79/554 (14%)
Query: 243 GQHVWRLKHFNKPAYCNL----CLNMLIGVGKQGLCCSFCKYTVHERCVA-------RAP 291
G+H+W + + +C + C+ ++ C+ CK VH C+ R
Sbjct: 96 GEHIWFETNVSGD-FCYVGEQYCVARMLQKSVSRRKCAACKIVVHTPCIEQLEKINFRCK 154
Query: 292 PSCIKTYVKSKRNTDVMHHYWVEGNCPT-KCDKCHKTVKCY-----QGLTGLHCVWCQIT 345
PS ++ ++ R + H+WV KC C K + + + + C WC+
Sbjct: 155 PSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQA 214
Query: 346 LHNKCA----SHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKS 401
H+K + ++ C G ++PPT I + P + + ++++ K KS
Sbjct: 215 YHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWI---LRARRPQNTLKASKKKKRASFKRKS 271
Query: 402 GSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQY 461
+ P + + + R TP P PLLVFVNPKSGG QG +I + F +
Sbjct: 272 SKKGPEEGRWRPFIIRP------------TPSPLMKPLLVFVNPKSGGNQGAKIIQSFLW 319
Query: 462 LLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAIL 521
LNPRQV+ LS GP L +R V + R+LACGGDGTVGW+L +++ + PPVAIL
Sbjct: 320 YLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAIL 379
Query: 522 PLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIPN------DKDEKG 575
PLGTGNDLAR L WGGGY E + KIL +E + LDRW PN D+DE
Sbjct: 380 PLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGA 439
Query: 576 -DPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCK 634
D +P + NNYFS+G DA + FH RE +PEKFNSR +NK +Y S+ + K
Sbjct: 440 TDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSK 499
Query: 635 KLHESVEIECDGVQI--DLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSD 692
L + + + CDG+ + + ++ + + LNIP G+ WG +
Sbjct: 500 DLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD---------- 549
Query: 693 KRTTVTDAKELKFASQDLSDQLLEVVGLE----GAMEMGQIYTGLKSAGRRLAQCSCVVI 748
F Q D LEV+G A+++G G RL QC VV+
Sbjct: 550 ------------FEPQRHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREVVL 590
Query: 749 RTSKSLPMQIDGEP 762
TSK++P+Q+DGEP
Sbjct: 591 TTSKAIPVQVDGEP 604
>gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens]
Length = 895
Score = 285 bits (730), Expect = 9e-77
Identities = 182/554 (32%), Positives = 267/554 (48%), Gaps = 79/554 (14%)
Query: 243 GQHVWRLKHFNKPAYCNL----CLNMLIGVGKQGLCCSFCKYTVHERCVA-------RAP 291
G+H+W + + +C + C+ ++ C+ CK VH C+ R
Sbjct: 62 GEHIWFETNVSGD-FCYVGEQYCVARMLQKSVSRRKCAACKIVVHTPCIEQLEKINFRCK 120
Query: 292 PSCIKTYVKSKRNTDVMHHYWVEGNCPT-KCDKCHKTVKCY-----QGLTGLHCVWCQIT 345
PS ++ ++ R + H+WV KC C K + + + + C WC+
Sbjct: 121 PSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQA 180
Query: 346 LHNKCA----SHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKS 401
H+K + ++ C G ++PPT I + P + + ++++ K KS
Sbjct: 181 YHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWI---LRARRPQNTLKASKKKKRASFKRKS 237
Query: 402 GSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQY 461
+ P + + + R TP P PLLVFVNPKSGG QG +I + F +
Sbjct: 238 SKKGPEEGRWRPFIIRP------------TPSPLMKPLLVFVNPKSGGNQGAKIIQSFLW 285
Query: 462 LLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAIL 521
LNPRQV+ LS GP L +R V + R+LACGGDGTVGW+L +++ + PPVAIL
Sbjct: 286 YLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAIL 345
Query: 522 PLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIPN------DKDEKG 575
PLGTGNDLAR L WGGGY E + KIL +E + LDRW PN D+DE
Sbjct: 346 PLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGA 405
Query: 576 -DPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCK 634
D +P + NNYFS+G DA + FH RE +PEKFNSR +NK +Y S+ + K
Sbjct: 406 TDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSK 465
Query: 635 KLHESVEIECDGVQI--DLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSD 692
L + + + CDG+ + + ++ + + LNIP G+ WG +
Sbjct: 466 DLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD---------- 515
Query: 693 KRTTVTDAKELKFASQDLSDQLLEVVGLE----GAMEMGQIYTGLKSAGRRLAQCSCVVI 748
F Q D LEV+G A+++G G RL QC VV+
Sbjct: 516 ------------FEPQRHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREVVL 556
Query: 749 RTSKSLPMQIDGEP 762
TSK++P+Q+DGEP
Sbjct: 557 TTSKAIPVQVDGEP 570
>gi|157688564 diacylglycerol kinase zeta isoform 4 [Homo sapiens]
Length = 1117
Score = 285 bits (729), Expect = 1e-76
Identities = 185/556 (33%), Positives = 267/556 (48%), Gaps = 84/556 (15%)
Query: 243 GQHVWRLKHFNKP------AYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVA-------R 289
G+H+W + + YC ML V ++ C+ CK VH C+ R
Sbjct: 285 GEHIWFETNVSGDFCYVGEQYC--VARMLKSVSRRK--CAACKIVVHTPCIEQLEKINFR 340
Query: 290 APPSCIKTYVKSKRNTDVMHHYWVEGNCPT-KCDKCHKTVKCY-----QGLTGLHCVWCQ 343
PS ++ ++ R + H+WV KC C K + + + + C WC+
Sbjct: 341 CKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCK 400
Query: 344 ITLHNKCA----SHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKE 399
H+K + ++ C G ++PPT I + P + + ++++ K
Sbjct: 401 QAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWI---LRARRPQNTLKASKKKKRASFKR 457
Query: 400 KSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKF 459
KS + P + + + R TP P PLLVFVNPKSGG QG +I + F
Sbjct: 458 KSSKKGPEEGRWRPFIIRP------------TPSPLMKPLLVFVNPKSGGNQGAKIIQSF 505
Query: 460 QYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVA 519
+ LNPRQV+ LS GP L +R V + R+LACGGDGTVGW+L +++ + PPVA
Sbjct: 506 LWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVA 565
Query: 520 ILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIPN------DKDE 573
ILPLGTGNDLAR L WGGGY E + KIL +E + LDRW PN D+DE
Sbjct: 566 ILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDE 625
Query: 574 KG-DPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSAT 632
D +P + NNYFS+G DA + FH RE +PEKFNSR +NK +Y S+ +
Sbjct: 626 GATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGS 685
Query: 633 CKKLHESVEIECDGVQI--DLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKG 690
K L + + + CDG+ + + ++ + + LNIP G+ WG +
Sbjct: 686 SKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD-------- 737
Query: 691 SDKRTTVTDAKELKFASQDLSDQLLEVVGLE----GAMEMGQIYTGLKSAGRRLAQCSCV 746
F Q D LEV+G A+++G G RL QC V
Sbjct: 738 --------------FEPQRHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREV 776
Query: 747 VIRTSKSLPMQIDGEP 762
V+ TSK++P+Q+DGEP
Sbjct: 777 VLTTSKAIPVQVDGEP 792
>gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens]
Length = 945
Score = 285 bits (729), Expect = 1e-76
Identities = 185/556 (33%), Positives = 267/556 (48%), Gaps = 84/556 (15%)
Query: 243 GQHVWRLKHFNKP------AYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVA-------R 289
G+H+W + + YC ML V ++ C+ CK VH C+ R
Sbjct: 113 GEHIWFETNVSGDFCYVGEQYC--VARMLKSVSRRK--CAACKIVVHTPCIEQLEKINFR 168
Query: 290 APPSCIKTYVKSKRNTDVMHHYWVEGNCPT-KCDKCHKTVKCY-----QGLTGLHCVWCQ 343
PS ++ ++ R + H+WV KC C K + + + + C WC+
Sbjct: 169 CKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCK 228
Query: 344 ITLHNKCA----SHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKE 399
H+K + ++ C G ++PPT I + P + + ++++ K
Sbjct: 229 QAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWI---LRARRPQNTLKASKKKKRASFKR 285
Query: 400 KSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKF 459
KS + P + + + R TP P PLLVFVNPKSGG QG +I + F
Sbjct: 286 KSSKKGPEEGRWRPFIIRP------------TPSPLMKPLLVFVNPKSGGNQGAKIIQSF 333
Query: 460 QYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVA 519
+ LNPRQV+ LS GP L +R V + R+LACGGDGTVGW+L +++ + PPVA
Sbjct: 334 LWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVA 393
Query: 520 ILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIPN------DKDE 573
ILPLGTGNDLAR L WGGGY E + KIL +E + LDRW PN D+DE
Sbjct: 394 ILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDE 453
Query: 574 KG-DPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSAT 632
D +P + NNYFS+G DA + FH RE +PEKFNSR +NK +Y S+ +
Sbjct: 454 GATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGS 513
Query: 633 CKKLHESVEIECDGVQI--DLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKG 690
K L + + + CDG+ + + ++ + + LNIP G+ WG +
Sbjct: 514 SKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD-------- 565
Query: 691 SDKRTTVTDAKELKFASQDLSDQLLEVVGLE----GAMEMGQIYTGLKSAGRRLAQCSCV 746
F Q D LEV+G A+++G G RL QC V
Sbjct: 566 --------------FEPQRHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREV 604
Query: 747 VIRTSKSLPMQIDGEP 762
V+ TSK++P+Q+DGEP
Sbjct: 605 VLTTSKAIPVQVDGEP 620
>gi|4503313 diacylglycerol kinase epsilon [Homo sapiens]
Length = 567
Score = 273 bits (697), Expect = 6e-73
Identities = 186/543 (34%), Positives = 264/543 (48%), Gaps = 83/543 (15%)
Query: 244 QHVWR-LKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSK 302
+H WR F++P YC +C ++ QG C C V E C+ +A + K
Sbjct: 59 KHGWRDTDLFSQPTYCCVCAQHIL----QGAFCDCCGLRVDEGCLRKADKRFQCKEIMLK 114
Query: 303 RNT---DVMHHYWVEGNCP--TKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASH-LKP 356
+T D M H+W+ GN P + C C + C L C+WCQ T+H++C + LK
Sbjct: 115 NDTKVLDAMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMKNSLKN 174
Query: 357 E-CDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKM 415
E CD G K+ I+PP+ + + + ++K+K +
Sbjct: 175 EKCDFGEFKNLIIPPSYLTSI-----------------NQMRKDKKTDYE---------- 207
Query: 416 QRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNG 475
V G Q TP L++ N +SG GE + +F+ LLNP QV+ ++
Sbjct: 208 -----VLASKLGKQWTP------LIILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTP 256
Query: 476 PMPGLNFFRDVPDF--RVLACGGDGTVGWVLDCIEKANVGKH----PPVAILPLGTGNDL 529
P+ L +P + RVL CGGDGTVGWVLD ++ + P VA+LPLGTGNDL
Sbjct: 257 PIKALQLCTLLPYYSARVLVCGGDGTVGWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDL 316
Query: 530 ARCLRWGGGYEGE-NLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFS 588
+ L WG GY GE + ++L+++ + I LDRWK +V P +++ NNYFS
Sbjct: 317 SNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDRWKVQVTNKGYYNLRKPKEFTM-NNYFS 375
Query: 589 IGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQ 648
+G DA +A FH REK P F+SR+ NK Y +GT + CK L++ VE+E DG +
Sbjct: 376 VGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKVELELDGER 435
Query: 649 IDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQ 708
+ L SLEGI +LNI GG LW E G + A
Sbjct: 436 VAL--PSLEGIIVLNIGYWGGGCRLW------------EGMGDE---------TYPLARH 472
Query: 709 DLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPC 768
D D LLEVVG+ G+ QI L + R + +I +PMQ+DGEPW Q PC
Sbjct: 473 D--DGLLEVVGVYGSFHCAQIQVKLANPFRIGQAHTVRLILKCSMMPMQVDGEPWAQGPC 530
Query: 769 TVS 771
TV+
Sbjct: 531 TVT 533
>gi|40806175 diacylglycerol kinase, theta [Homo sapiens]
Length = 942
Score = 254 bits (648), Expect = 3e-67
Identities = 141/343 (41%), Positives = 200/343 (58%), Gaps = 37/343 (10%)
Query: 434 PGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLA 493
P + PLLVFVNPKSGG +G + F+ LLNP QV+ L+ GP+PGL+ F VP FRVL
Sbjct: 584 PDSCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLV 643
Query: 494 CGGDGTVGWVLDCIEKAN---VGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKD 550
CGGDGTVGWVL +E+ P VAILPLGTGNDL R LRWG GY GE+ +L
Sbjct: 644 CGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLLS 703
Query: 551 IENSTEIMLDRWKFEVIPND----KDEKGDPVPYSII--NNYFSIGVDASIAHRFHIMRE 604
++ + +++DRW + ++ +++ D P I+ +NY IG+DA ++ FH RE
Sbjct: 704 VDEADAVLMDRWTILLDAHEAGSAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQARE 763
Query: 605 KHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIAILNI 664
+ P KF SR+ NK Y G + + + LH+ + ++ + +++L S+EG+ +NI
Sbjct: 764 EEPGKFTSRLHNKGVYVRVGLQKI--SHSRSLHKQIRLQVERQEVEL--PSIEGLIFINI 819
Query: 665 PSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGAM 724
PS G++LW GSD T +F + D LLEVVG+ G +
Sbjct: 820 PSWGSGADLW---------------GSDSDT--------RFEKPRMDDGLLEVVGVTGVV 856
Query: 725 EMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTP 767
MGQ+ GL+S G R+AQ S + K+ P+Q+DGEPW+Q P
Sbjct: 857 HMGQVQGGLRS-GIRIAQGSYFRVTLLKATPVQVDGEPWVQAP 898
Score = 86.3 bits (212), Expect = 1e-16
Identities = 41/131 (31%), Positives = 65/131 (49%), Gaps = 5/131 (3%)
Query: 245 HVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRN 304
H + + +K +C +C +L L C C+ +H CV A C + + ++
Sbjct: 122 HCFGPRGLHKRKFCAVCRKVLEA---PALHCEVCELHLHPDCVPFACSDCRQCHQDGHQD 178
Query: 305 TDVMHHYWVEGNCPT--KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGP 362
D HH+W EGN P+ +C+ C KT L G+ C WC + H+ C++ L PEC G
Sbjct: 179 HDTHHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGR 238
Query: 363 LKDHILPPTTI 373
L+ +LPP +
Sbjct: 239 LRSLVLPPACV 249
Score = 51.2 bits (121), Expect = 4e-06
Identities = 31/115 (26%), Positives = 47/115 (40%), Gaps = 8/115 (6%)
Query: 245 HVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRN 304
H +R KP +C+LC + + G+ G C C + HE+C+ C + S
Sbjct: 61 HSFRKVTLTKPTFCHLCSDFIWGLA--GFLCDVCNFMSHEKCLKHVRIPC-TSVAPSLVR 117
Query: 305 TDVMHHYWVEGNCPTK-CDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPEC 358
V H + G K C C K ++ LHC C++ LH C +C
Sbjct: 118 VPVAHCFGPRGLHKRKFCAVCRKVLEA----PALHCEVCELHLHPDCVPFACSDC 168
>gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo
sapiens]
Length = 1170
Score = 210 bits (534), Expect = 5e-54
Identities = 120/330 (36%), Positives = 154/330 (46%), Gaps = 55/330 (16%)
Query: 243 GQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSK 302
G H W +P YCN+C L GV GL C CK+ H+RC RA +C T + S
Sbjct: 118 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 177
Query: 303 RNTDV-------MHHYWVEGNCPT--KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASH 353
+ M H W+EGN P KC C KT L C+WC+ +H C
Sbjct: 178 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 237
Query: 354 LKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKN 413
L +C G K ++PPT +
Sbjct: 238 LLTKCPLGLCKVSVIPPTAL---------------------------------------- 257
Query: 414 KMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSG 473
NS+ DG P T PLLVFVN KSG QG + R+F+ LLNP QV+ L
Sbjct: 258 -----NSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMN 312
Query: 474 NGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCL 533
GP GL F+ FR+L CGGDG+VGWVL I+ N+ K + +LPLGTGNDLAR L
Sbjct: 313 GGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVL 372
Query: 534 RWGGGYEGE-NLMKILKDIENSTEIMLDRW 562
WG + + L +IL+ +E ++ MLDRW
Sbjct: 373 GWGSACDDDTQLPQILEKLERASTKMLDRW 402
Score = 127 bits (320), Expect = 3e-29
Identities = 74/188 (39%), Positives = 104/188 (55%), Gaps = 27/188 (14%)
Query: 582 IINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVE 641
++NNYF IG+DA I+ F+ R++HPEK SR KN WY GT E T K L + V
Sbjct: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778
Query: 642 IECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAK 701
+ECDG I L SL+GIA+LNIPS GG+N WG +K +
Sbjct: 779 LECDGRPIPL--PSLQGIAVLNIPSYAGGTNFWGGTK----------------------E 814
Query: 702 ELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRT--SKSLPMQID 759
+ FA+ D++LEVV + G+M+M + ++ R+AQC V I + +P+Q+D
Sbjct: 815 DDTFAAPSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQVD 873
Query: 760 GEPWMQTP 767
GE W+Q P
Sbjct: 874 GEAWVQPP 881
>gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo
sapiens]
Length = 1214
Score = 210 bits (534), Expect = 5e-54
Identities = 120/330 (36%), Positives = 154/330 (46%), Gaps = 55/330 (16%)
Query: 243 GQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSK 302
G H W +P YCN+C L GV GL C CK+ H+RC RA +C T + S
Sbjct: 162 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 221
Query: 303 RNTDV-------MHHYWVEGNCPT--KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASH 353
+ M H W+EGN P KC C KT L C+WC+ +H C
Sbjct: 222 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 281
Query: 354 LKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKN 413
L +C G K ++PPT +
Sbjct: 282 LLTKCPLGLCKVSVIPPTAL---------------------------------------- 301
Query: 414 KMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSG 473
NS+ DG P T PLLVFVN KSG QG + R+F+ LLNP QV+ L
Sbjct: 302 -----NSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMN 356
Query: 474 NGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCL 533
GP GL F+ FR+L CGGDG+VGWVL I+ N+ K + +LPLGTGNDLAR L
Sbjct: 357 GGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVL 416
Query: 534 RWGGGYEGE-NLMKILKDIENSTEIMLDRW 562
WG + + L +IL+ +E ++ MLDRW
Sbjct: 417 GWGSACDDDTQLPQILEKLERASTKMLDRW 446
Score = 127 bits (320), Expect = 3e-29
Identities = 74/188 (39%), Positives = 104/188 (55%), Gaps = 27/188 (14%)
Query: 582 IINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVE 641
++NNYF IG+DA I+ F+ R++HPEK SR KN WY GT E T K L + V
Sbjct: 763 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 822
Query: 642 IECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAK 701
+ECDG I L SL+GIA+LNIPS GG+N WG +K +
Sbjct: 823 LECDGRPIPL--PSLQGIAVLNIPSYAGGTNFWGGTK----------------------E 858
Query: 702 ELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRT--SKSLPMQID 759
+ FA+ D++LEVV + G+M+M + ++ R+AQC V I + +P+Q+D
Sbjct: 859 DDTFAAPSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQVD 917
Query: 760 GEPWMQTP 767
GE W+Q P
Sbjct: 918 GEAWVQPP 925
>gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens]
Length = 1164
Score = 207 bits (526), Expect = 4e-53
Identities = 121/330 (36%), Positives = 155/330 (46%), Gaps = 56/330 (16%)
Query: 243 GQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKS- 301
G H W +P +CN+C L GV GL C CK+ H+RC RA +C T + S
Sbjct: 174 GMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 233
Query: 302 ------KRNTDVMHHYWVEGNCPT--KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASH 353
+ M H W+EGN P KC C KT L C+WC+ +H C
Sbjct: 234 GKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDL 293
Query: 354 LKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKN 413
P C G K I+PP +
Sbjct: 294 YHPICPLGQCKVSIIPPIAL---------------------------------------- 313
Query: 414 KMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSG 473
NS DG + T PLLVFVN KSG QG + R+F+ LLNP QV+ L
Sbjct: 314 -----NSTDSDGF-CRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMN 367
Query: 474 NGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCL 533
GP GL F+ +FR+L CGGDG+VGWVL I+K N+ K + +LPLGTGNDLAR L
Sbjct: 368 GGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARVL 427
Query: 534 RWGGGYEGE-NLMKILKDIENSTEIMLDRW 562
WGG Y+ + L +IL+ +E ++ MLDRW
Sbjct: 428 GWGGSYDDDTQLPQILEKLERASTKMLDRW 457
Score = 127 bits (320), Expect = 3e-29
Identities = 74/188 (39%), Positives = 104/188 (55%), Gaps = 27/188 (14%)
Query: 582 IINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVE 641
++NNYF IG+DA I+ F+ RE+HPEK SR KN WY GT E + K L + V+
Sbjct: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829
Query: 642 IECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAK 701
+ECDG I L SL+GIA+LNIPS GG+N WG +K +
Sbjct: 830 LECDGQYIPL--PSLQGIAVLNIPSYAGGTNFWGGTK----------------------E 865
Query: 702 ELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRT--SKSLPMQID 759
+ FA+ D++LEVV + +M+M + +K R+AQC V I + +P+Q+D
Sbjct: 866 DDIFAAPSFDDKILEVVAIFDSMQMA-VSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVD 924
Query: 760 GEPWMQTP 767
GE W+Q P
Sbjct: 925 GEAWVQPP 932
>gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens]
Length = 1220
Score = 207 bits (526), Expect = 4e-53
Identities = 121/330 (36%), Positives = 155/330 (46%), Gaps = 56/330 (16%)
Query: 243 GQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKS- 301
G H W +P +CN+C L GV GL C CK+ H+RC RA +C T + S
Sbjct: 174 GMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 233
Query: 302 ------KRNTDVMHHYWVEGNCPT--KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASH 353
+ M H W+EGN P KC C KT L C+WC+ +H C
Sbjct: 234 GKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDL 293
Query: 354 LKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKN 413
P C G K I+PP +
Sbjct: 294 YHPICPLGQCKVSIIPPIAL---------------------------------------- 313
Query: 414 KMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSG 473
NS DG + T PLLVFVN KSG QG + R+F+ LLNP QV+ L
Sbjct: 314 -----NSTDSDGF-CRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMN 367
Query: 474 NGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCL 533
GP GL F+ +FR+L CGGDG+VGWVL I+K N+ K + +LPLGTGNDLAR L
Sbjct: 368 GGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARVL 427
Query: 534 RWGGGYEGE-NLMKILKDIENSTEIMLDRW 562
WGG Y+ + L +IL+ +E ++ MLDRW
Sbjct: 428 GWGGSYDDDTQLPQILEKLERASTKMLDRW 457
Score = 127 bits (320), Expect = 3e-29
Identities = 74/188 (39%), Positives = 104/188 (55%), Gaps = 27/188 (14%)
Query: 582 IINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVE 641
++NNYF IG+DA I+ F+ RE+HPEK SR KN WY GT E + K L + V+
Sbjct: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829
Query: 642 IECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAK 701
+ECDG I L SL+GIA+LNIPS GG+N WG +K +
Sbjct: 830 LECDGQYIPL--PSLQGIAVLNIPSYAGGTNFWGGTK----------------------E 865
Query: 702 ELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRT--SKSLPMQID 759
+ FA+ D++LEVV + +M+M + +K R+AQC V I + +P+Q+D
Sbjct: 866 DDIFAAPSFDDKILEVVAIFDSMQMA-VSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVD 924
Query: 760 GEPWMQTP 767
GE W+Q P
Sbjct: 925 GEAWVQPP 932
>gi|62000702 diacylglycerol kinase kappa [Homo sapiens]
Length = 1271
Score = 183 bits (464), Expect = 6e-46
Identities = 112/363 (30%), Positives = 166/363 (45%), Gaps = 59/363 (16%)
Query: 216 LEEWI-------QGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGV 268
+EEWI QG + IP ENN G H W + ++ +CN+C + +
Sbjct: 297 MEEWINIIKTIQQGEIYKIP-----AAENNPFLVGMHCWYSSYSHRTQHCNVCRESIPAL 351
Query: 269 GKQGLCCSFCKYTVHERCVARAPPSC------IKTYVKSKRNTDVMHHYWVEGNCP--TK 320
+ + C CK H C RA C I + + M H WVEGN P ++
Sbjct: 352 SRDAIICEVCKVKSHRLCALRASKDCKWNTLSITDDLLLPADEVNMPHQWVEGNMPVSSQ 411
Query: 321 CDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHILPPTTICPVVLQT 380
C CH++ YQ L C+WC T+H+ C EC + ++PPT +
Sbjct: 412 CAVCHESCGSYQRLQDFRCLWCNSTVHDDCRRRFSKECCFRSHRSSVIPPTAL------- 464
Query: 381 LPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLL 440
+ G Q D + +++ + PLL
Sbjct: 465 -----------------SDPKGDGQLVVSSDFWNLDWSSACSC--------------PLL 493
Query: 441 VFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTV 500
+F+N KSG QG RKF+ LNP QV+ L GP GL+ F++ FR+L CGGDG+V
Sbjct: 494 IFINSKSGDHQGIVFLRKFKQYLNPSQVFDLLKGGPEAGLSMFKNFARFRILVCGGDGSV 553
Query: 501 GWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGY-EGENLMKILKDIENSTEIML 559
WVL I+ + + +A++PLGTGNDLAR L WG + + ++ + IL +E ++ +L
Sbjct: 554 SWVLSLIDAFGLHEKCQLAVIPLGTGNDLARVLGWGAFWNKSKSPLDILNRVEQASVRIL 613
Query: 560 DRW 562
DRW
Sbjct: 614 DRW 616
Score = 120 bits (302), Expect = 4e-27
Identities = 71/188 (37%), Positives = 103/188 (54%), Gaps = 27/188 (14%)
Query: 582 IINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVE 641
++NNYF IG+DA I+ F+ R++HP ++NSR+KNK WY GT E + +KL E V
Sbjct: 857 VMNNYFGIGLDAKISLDFNTRRDEHPGQYNSRLKNKMWYGLLGTKELLQRSYRKLEERVH 916
Query: 642 IECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAK 701
+ECDG I L N L+GI +LNI S GG N W GS+ TT
Sbjct: 917 LECDGETISLPN--LQGIVVLNITSYAGGINFW---------------GSNTATT----- 954
Query: 702 ELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRT--SKSLPMQID 759
++ + + D LEVV + G+++M + R+AQC V+I + +P+Q+D
Sbjct: 955 --EYEAPAIDDGKLEVVAIFGSVQMAMSRI-INLHHHRIAQCHEVMITIDGEEGIPVQVD 1011
Query: 760 GEPWMQTP 767
GE W+Q P
Sbjct: 1012 GEAWIQRP 1019
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 61.6 bits (148), Expect = 3e-09
Identities = 51/196 (26%), Positives = 80/196 (40%), Gaps = 29/196 (14%)
Query: 236 ENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSC- 294
+ NV + H + + F +P +C+ C + + G GKQG C C + VH+RC SC
Sbjct: 28 QKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCP 87
Query: 295 ------IKTYVKSKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGL--TGLHCVWCQITL 346
+SK + H Y + PT CD C + GL G+ C C + +
Sbjct: 88 GADKGPASDDPRSKHKFKI-HTY----SSPTFCDHCGSLL---YGLIHQGMKCDTCMMNV 139
Query: 347 HNKCASHLKPECDCGP--------LKDHILPPTTICPV----VLQTLPTSGVSVPEERQS 394
H +C ++ C ++ HI I V L + +G+S P +
Sbjct: 140 HKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLK 199
Query: 395 TVKKEKSGSQQPNKVI 410
+ KS S+Q K I
Sbjct: 200 LIPDPKSESKQKTKTI 215
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 61.6 bits (148), Expect = 3e-09
Identities = 51/196 (26%), Positives = 80/196 (40%), Gaps = 29/196 (14%)
Query: 236 ENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSC- 294
+ NV + H + + F +P +C+ C + + G GKQG C C + VH+RC SC
Sbjct: 28 QKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCP 87
Query: 295 ------IKTYVKSKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGL--TGLHCVWCQITL 346
+SK + H Y + PT CD C + GL G+ C C + +
Sbjct: 88 GADKGPASDDPRSKHKFKI-HTY----SSPTFCDHCGSLL---YGLIHQGMKCDTCMMNV 139
Query: 347 HNKCASHLKPECDCGP--------LKDHILPPTTICPV----VLQTLPTSGVSVPEERQS 394
H +C ++ C ++ HI I V L + +G+S P +
Sbjct: 140 HKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLK 199
Query: 395 TVKKEKSGSQQPNKVI 410
+ KS S+Q K I
Sbjct: 200 LIPDPKSESKQKTKTI 215
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 61.2 bits (147), Expect = 3e-09
Identities = 34/122 (27%), Positives = 55/122 (45%), Gaps = 15/122 (12%)
Query: 245 HVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSC------IKTY 298
H + + F +P +C+ C + + G+GKQGL C C + VH RC C +T
Sbjct: 36 HKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTD 95
Query: 299 VKSKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLT--GLHCVWCQITLHNKCASHLKP 356
++ +H Y + PT CD C + GL G+ C C++ +H +C +
Sbjct: 96 DPRNKHKFRLHSY----SSPTFCDHCGSLL---YGLVHQGMKCSCCEMNVHRRCVRSVPS 148
Query: 357 EC 358
C
Sbjct: 149 LC 150
Score = 51.6 bits (122), Expect = 3e-06
Identities = 28/85 (32%), Positives = 43/85 (50%), Gaps = 7/85 (8%)
Query: 244 QHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKR 303
+H +RL ++ P +C+ C ++L G+ QG+ CS C+ VH RCV P C
Sbjct: 100 KHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLC------GVD 153
Query: 304 NTDVMHHYWVEGNCPTKCDKCHKTV 328
+T+ +E PT D+ H TV
Sbjct: 154 HTERRGRLQLEIRAPT-ADEIHVTV 177
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 60.8 bits (146), Expect = 5e-09
Identities = 35/125 (28%), Positives = 57/125 (45%), Gaps = 14/125 (11%)
Query: 245 HVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKT------- 297
H + F +P +C++C + + G+ KQG C C +H++C+ + C T
Sbjct: 159 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDT 218
Query: 298 -YVKSKRNTDVMHHYWVEG-NCPTKCDKCHKTVKCYQGLT--GLHCVWCQITLHNKCASH 353
+ K + N D+ H + V PT CD C + GL GL C C + +H+KC
Sbjct: 219 IFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLL---WGLVKQGLKCEDCGMNVHHKCREK 275
Query: 354 LKPEC 358
+ C
Sbjct: 276 VANLC 280
Score = 41.6 bits (96), Expect = 0.003
Identities = 17/53 (32%), Positives = 29/53 (54%)
Query: 242 DGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSC 294
D H +++ ++ P +C+ C ++L G+ KQGL C C VH +C + C
Sbjct: 228 DMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLC 280
>gi|31377782 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 60.8 bits (146), Expect = 5e-09
Identities = 35/125 (28%), Positives = 57/125 (45%), Gaps = 14/125 (11%)
Query: 245 HVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKT------- 297
H + F +P +C++C + + G+ KQG C C +H++C+ + C T
Sbjct: 159 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDT 218
Query: 298 -YVKSKRNTDVMHHYWVEG-NCPTKCDKCHKTVKCYQGLT--GLHCVWCQITLHNKCASH 353
+ K + N D+ H + V PT CD C + GL GL C C + +H+KC
Sbjct: 219 IFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLL---WGLVKQGLKCEDCGMNVHHKCREK 275
Query: 354 LKPEC 358
+ C
Sbjct: 276 VANLC 280
Score = 41.6 bits (96), Expect = 0.003
Identities = 17/53 (32%), Positives = 29/53 (54%)
Query: 242 DGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSC 294
D H +++ ++ P +C+ C ++L G+ KQGL C C VH +C + C
Sbjct: 228 DMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLC 280
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 59.3 bits (142), Expect = 1e-08
Identities = 48/195 (24%), Positives = 77/195 (39%), Gaps = 27/195 (13%)
Query: 236 ENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSC- 294
+ NV + H + + F +P +C+ C + + G GKQG C C + VH+RC SC
Sbjct: 28 QKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCP 87
Query: 295 -----IKTYVKSKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGL--TGLHCVWCQITLH 347
T ++ +H Y PT CD C + GL G+ C C + +H
Sbjct: 88 GADKGPDTDDPRSKHKFKIHTY----GSPTFCDHCGSLL---YGLIHQGMKCDTCDMNVH 140
Query: 348 NKCASHLKPECDC------------GPLKDHILPPTTICPVVLQTLPTSGVSVPEERQST 395
+C ++ C + D L T L + +G+S P +
Sbjct: 141 KQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKL 200
Query: 396 VKKEKSGSQQPNKVI 410
+ K+ S+Q K I
Sbjct: 201 IPDPKNESKQKTKTI 215
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 58.2 bits (139), Expect = 3e-08
Identities = 37/126 (29%), Positives = 58/126 (46%), Gaps = 15/126 (11%)
Query: 245 HVWRLKHFNKPAYCNLCLNMLIGV-GKQGLCCSFCKYTVHERCVARAPPSC-------IK 296
H + + +P YC+ C + + GV GKQG C C VH+RC C
Sbjct: 170 HKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETP 229
Query: 297 TYVKSKR-NTDVMHHYWVEG-NCPTKCDKCHKTVKCYQGL--TGLHCVWCQITLHNKCAS 352
V S+R + ++ H + + PT CD C + GL GL C C++ +H +C +
Sbjct: 230 DQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLL---WGLLRQGLQCKVCKMNVHRRCET 286
Query: 353 HLKPEC 358
++ P C
Sbjct: 287 NVAPNC 292
>gi|40254415 guanylate cyclase activator 1A (retina) [Homo sapiens]
Length = 201
Score = 58.2 bits (139), Expect = 3e-08
Identities = 33/90 (36%), Positives = 50/90 (55%), Gaps = 1/90 (1%)
Query: 133 IHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYLEWDV 192
I + V LSL+ +G+ E KL + F+LYD DGNG +D EL II + + + +
Sbjct: 71 IDFMEYVAALSLVLKGKVEQKLRWYFKLYDVDGNGCIDRDELLTIIQAIRAINPCSDTTM 130
Query: 193 TELNPILHEMMEEIDYDHDGTVSLEEWIQG 222
T + +ID + DG +SLEE+I+G
Sbjct: 131 T-AEEFTDTVFSKIDVNGDGELSLEEFIEG 159
>gi|19913446 hippocalcin [Homo sapiens]
Length = 193
Score = 58.2 bits (139), Expect = 3e-08
Identities = 34/111 (30%), Positives = 61/111 (54%), Gaps = 3/111 (2%)
Query: 126 NTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQMMH-V 184
+T S I ++ + LS+ RGR E KL + F +YD DGNG++ E+ I+ + V
Sbjct: 73 DTNSDGTIDFREFIIALSVTSRGRLEQKLMWAFSMYDLDGNGYISREEMLEIVQAIYKMV 132
Query: 185 AEYLEWDVTELNP--ILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLL 233
+ ++ E P ++ ++D ++DG +SLEE+I+G + ++ LL
Sbjct: 133 SSVMKMPEDESTPEKRTEKIFRQMDTNNDGKLSLEEFIRGAKSDPSIVRLL 183
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,078,201
Number of Sequences: 37866
Number of extensions: 1639601
Number of successful extensions: 5981
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 141
Number of HSP's successfully gapped in prelim test: 127
Number of HSP's that attempted gapping in prelim test: 5272
Number of HSP's gapped (non-prelim): 589
length of query: 773
length of database: 18,247,518
effective HSP length: 110
effective length of query: 663
effective length of database: 14,082,258
effective search space: 9336537054
effective search space used: 9336537054
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.