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Search of human proteins with 21735552
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21735552 mitogen-activated protein kinase kinase kinase 12
[Homo sapiens]
(859 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 1759 0.0
gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho... 844 0.0
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 280 4e-75
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho... 258 2e-68
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho... 246 5e-65
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 242 9e-64
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 213 6e-55
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 213 6e-55
gi|33188459 B-Raf [Homo sapiens] 154 3e-37
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso... 152 2e-36
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso... 152 2e-36
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso... 152 2e-36
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof... 152 2e-36
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens] 148 2e-35
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens] 148 2e-35
gi|4502193 v-raf murine sarcoma 3611 viral oncogene homolog [Hom... 145 2e-34
gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens] 141 2e-33
gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens] 141 2e-33
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] 141 2e-33
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens] 141 2e-33
gi|187475373 c-src tyrosine kinase [Homo sapiens] 141 3e-33
gi|4758078 c-src tyrosine kinase [Homo sapiens] 141 3e-33
gi|4503787 fyn-related kinase [Homo sapiens] 141 3e-33
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 139 9e-33
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 139 9e-33
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 139 9e-33
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 139 9e-33
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 139 9e-33
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 139 9e-33
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 139 1e-32
>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
sapiens]
Length = 859
Score = 1759 bits (4556), Expect = 0.0
Identities = 859/859 (100%), Positives = 859/859 (100%)
Query: 1 MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGG 60
MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGG
Sbjct: 1 MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGG 60
Query: 61 AAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEV 120
AAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEV
Sbjct: 61 AAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEV 120
Query: 121 PFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVC 180
PFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVC
Sbjct: 121 PFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVC 180
Query: 181 TQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSP 240
TQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSP
Sbjct: 181 TQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSP 240
Query: 241 NMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVL 300
NMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVL
Sbjct: 241 NMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVL 300
Query: 301 WELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQI 360
WELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQI
Sbjct: 301 WELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQI 360
Query: 361 LLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELR 420
LLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELR
Sbjct: 361 LLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELR 420
Query: 421 HALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGL 480
HALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGL
Sbjct: 421 HALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGL 480
Query: 481 LHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKAPPSPGRS 540
LHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKAPPSPGRS
Sbjct: 481 LHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKAPPSPGRS 540
Query: 541 RRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHD 600
RRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHD
Sbjct: 541 RRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHD 600
Query: 601 LLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGG 660
LLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGG
Sbjct: 601 LLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGG 660
Query: 661 AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSE 720
AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSE
Sbjct: 661 AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSE 720
Query: 721 EEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNT 780
EEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNT
Sbjct: 721 EEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNT 780
Query: 781 DERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDST 840
DERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDST
Sbjct: 781 DERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDST 840
Query: 841 ELDNSNSVDALRPPASLPP 859
ELDNSNSVDALRPPASLPP
Sbjct: 841 ELDNSNSVDALRPPASLPP 859
>gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo
sapiens]
Length = 966
Score = 844 bits (2180), Expect = 0.0
Identities = 482/891 (54%), Positives = 582/891 (65%), Gaps = 83/891 (9%)
Query: 33 TSDCTPEKDLTPTHVLQLHEQDAGGPGGAAGSPES--RASRVRADEVRLQ-CQSGSG--- 86
TS +D VLQL E D + G+ + S +++++Q +SGSG
Sbjct: 70 TSVSEDSRDQFENSVLQLREHDESETAVSQGNSNTVDGESTSGTEDIKIQFSRSGSGSGG 129
Query: 87 FLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHG 146
FLEGLFGCLRPVW +IGKAYST++K QQ+D WEVPFEEI +LQW+GSGAQGAVFLG+F
Sbjct: 130 FLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRA 189
Query: 147 EEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGR 206
EEVA+KKVR+ ETDIKHLRKLKHPNII FKGVCTQAPCYCI+ME+CA GQLYEVLRAGR
Sbjct: 190 EEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGR 249
Query: 207 PVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKST 266
+TP LLVDWS GIA GMNYLHLHKIIHRDLKSPN+L+T+ D VKISDFGTSKELSDKST
Sbjct: 250 KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKST 309
Query: 267 KMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNS 326
KMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNS
Sbjct: 310 KMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNS 369
Query: 327 LHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEW 386
LHLPVPS+CPDGFKIL++Q W SKPRNRPSFRQ L+HLDIASADVL+TPQETYFKSQAEW
Sbjct: 370 LHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQETYFKSQAEW 429
Query: 387 REEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNAL 446
REEVK HFEKIKSEGTC+HRL+EEL+ RRREELRHALDIREHYERKLERANNLYMEL+A+
Sbjct: 430 REEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERANNLYMELSAI 489
Query: 447 MLQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRP 506
MLQLE++E+EL++REQA+E++ PG K HP R ++H N MEKL+K++ VP K +KRP
Sbjct: 490 MLQLEMREKELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKSGMQTKRP 549
Query: 507 DILKTESLLPKLDAALSGVGLPGCPKAPPSPGRSR-RGKTRHRKASAKGSCGDLPGLRTA 565
D+L++E +P + A + L G PK S +SR R K RHR+ +++GS D A
Sbjct: 550 DLLRSEG-IPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHSDF----AA 604
Query: 566 VPPHEPGGPGSP------GGLGGGPS---------AWEACPPALRGLHHDLL-------- 602
+ ++P SP PS ++ PPA+ HH L
Sbjct: 605 ILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIA 664
Query: 603 -----------------------LRKMSSSSPDLLSAALGS---------RGRGATGGAG 630
R++ SSPDL+S A+ + +G+ G
Sbjct: 665 TCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGPWGCC 724
Query: 631 DPGSPPPARGDTPPSEGSAP-GSTSP--DSPGGAKGEPPPPVGPGEGVGLLGTGREGTSG 687
+ P P GS S P SP +K P+ E +
Sbjct: 725 QADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENAQSSEKTEENEFSGC 784
Query: 688 RGGSRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELTSSQRWPQSLNMRQS 747
R S G+ HL L R + SSEEEEGEVDSEVE QR + ++ QS
Sbjct: 785 RSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCISSCQS 844
Query: 748 LSTFSSEN--PSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLD-PPP 804
STFSSEN SDGEEG S+ S S P+ + ++R E+ DD+ SQ EIP+D
Sbjct: 845 YSTFSSENFSVSDGEEGNTSDHSNS--PDELADKLEDRLAEKLDDLLSQTPEIPIDISSH 902
Query: 805 SEVIPGPEPSSLPIPHQELL-----RERG---PPNSEDSDCDSTELDNSNS 847
S+ + E + + Q L ERG P E+SDCDS++ + S++
Sbjct: 903 SDGLSDKECAVRRVKTQMSLGKLCVEERGYENPMQFEESDCDSSDGECSDA 953
>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
sapiens]
Length = 954
Score = 280 bits (716), Expect = 4e-75
Identities = 239/748 (31%), Positives = 334/748 (44%), Gaps = 83/748 (11%)
Query: 119 EVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETD-----------IKHLRK 167
E+PF E+ + +G G G V+ + GEEVAVK R E D +
Sbjct: 92 EIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGA 151
Query: 168 LKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYL 227
L+HPNII +G C P C++ME+ G L VL AGR V P +LV+W++ +A GMNYL
Sbjct: 152 LQHPNIIALRGACLNPPHLCLVMEYARGGALSRVL-AGRRVPPHVLVNWAVQVARGMNYL 210
Query: 228 HLHK---IIHRDLKSPNMLITY--------DDVVKISDFGTSKELSDKSTKMSFAGTVAW 276
H IIHRDLKS N+LI D V+KI+DFG ++E K+TKMS AGT AW
Sbjct: 211 HNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWH-KTTKMSAAGTYAW 269
Query: 277 MAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCP 336
MAPEVIR S+ D+WSFGV+LWELLTGE+PY+++D+ A+ +GV N L LP+PS+CP
Sbjct: 270 MAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCP 329
Query: 337 DGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVL-STPQETYFKSQAEWREEVKLHFE 395
+ F LL +CW+ P RP F IL L++ L P E++ Q +W+ E++ F+
Sbjct: 330 EPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFD 389
Query: 396 KIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLY-MELNALMLQLE--- 451
++++ L EEEL+ +E+ +R + ER ++ EL+ LM QL
Sbjct: 390 DLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEK 449
Query: 452 ---LKERELLRREQALERRCPGLLKPHPSRGLLHGNTME--KLIKKRNVPQKLSPHSKRP 506
K + +R + L+ R G PS G H T++ + KR SP +
Sbjct: 450 PRVRKRKGNFKRSRLLKLREGGSHISLPS-GFEHKITVQASPTLDKRKGSDGASPPA--- 505
Query: 507 DILKTESLLPKLDA-ALSGVGLPGCPKAPPSPGR---SRRGKTRHRKASAKGSCGDLPGL 562
+ S++P+L A L+ V G S G SR G + + G G
Sbjct: 506 ----SPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGRTWGP 561
Query: 563 RTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRG 622
+ + GG GLG G W + P L SP A G
Sbjct: 562 SSTLQKERVGGEERLKGLGEGSKQWSSSAPNL-------------GKSPKHTPIAPGFAS 608
Query: 623 RGAT---GGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLG 679
A D GS P + PS S P P A EP P P
Sbjct: 609 LNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPPARW----- 663
Query: 680 TGREGTSGRGGSRAGSQHLTPAALLYRA---AVTRSQKRGISSEEEEGEVDSEVELTSSQ 736
G G R L A L A ++ R EE+ +D + +
Sbjct: 664 -------GHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDG-LFFPRAG 715
Query: 737 RWPQSLN-MRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQG 795
R+P+ L+ + P G +A+ S S + ST + R D SD+
Sbjct: 716 RFPRGLSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSD--SDEAAPAA 773
Query: 796 SEIPLDPPPSEVIPGPEPSSLPIPHQEL 823
P P P P P PS+ P+ EL
Sbjct: 774 PSPP--PSPPAPTPTPSPSTNPLVDLEL 799
>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
sapiens]
Length = 847
Score = 258 bits (658), Expect = 2e-68
Identities = 202/603 (33%), Positives = 287/603 (47%), Gaps = 76/603 (12%)
Query: 122 FEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDI-----------KHLRKLKH 170
F+E+ + +G G G V+ G + GE VAVK R + DI + L H
Sbjct: 114 FQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAH 173
Query: 171 PNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLH-- 228
PNII K VC + P C++ME+ A G L L AGR V P +LV+W++ IA GM+YLH
Sbjct: 174 PNIIALKAVCLEEPNLCLVMEYAAGGPLSRAL-AGRRVPPHVLVNWAVQIARGMHYLHCE 232
Query: 229 -LHKIIHRDLKSPNML----ITYDDV----VKISDFGTSKELSDKSTKMSFAGTVAWMAP 279
L +IHRDLKS N+L I DD+ +KI+DFG ++E K+T+MS AGT AWMAP
Sbjct: 233 ALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWH-KTTQMSAAGTYAWMAP 291
Query: 280 EVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGF 339
EVI+ S+ D+WSFGV+LWELLTGE+PY+ +D A+ +GV N L LP+PS+CP+ F
Sbjct: 292 EVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPF 351
Query: 340 KILLRQCWNSKPRNRPSFRQILLHLDIASADVL-STPQETYFKSQAEWREEVKLHFEKIK 398
L+ CW P RP F IL L+ A VL P++++ Q W+ E++ F++++
Sbjct: 352 AQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELR 411
Query: 399 SEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALMLQLELKERELL 458
++ L EEEL RE+ A +R + ++ L+LQ +ER +
Sbjct: 412 AKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHV 471
Query: 459 RREQALERRCPGLLKPHPSR-----GLLHGNTMEK---LIKKRNVPQ---KLSPHSKRPD 507
RR + +R + R H T++ L ++RNV + SP R
Sbjct: 472 RRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFR 531
Query: 508 ILKTESLLP----------KLDAALSGVGLPGCPKAP--PSPGRSRRGKTRHRKASAKGS 555
++ E P +L+ + +G P P PG ++ G+ R R A
Sbjct: 532 AIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWY 591
Query: 556 CGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLS 615
P P G+P P + PA RG SS +P L+
Sbjct: 592 LDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERG---------SSSGTPKLIQ 642
Query: 616 AALGSRGRGATGGAG------DPGSPPPARGD---TPPSEGSAPGSTSPDSPGGAKGEPP 666
AL RG G PG P RG+ TPP+ AP T P PP
Sbjct: 643 RAL-LRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEP---------PP 692
Query: 667 PPV 669
P+
Sbjct: 693 SPL 695
>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
sapiens]
Length = 1118
Score = 246 bits (629), Expect = 5e-65
Identities = 144/369 (39%), Positives = 214/369 (57%), Gaps = 26/369 (7%)
Query: 117 LWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDI-----------KHL 165
L E+ F E+ + +G G G V+ + G+EVAVK R + DI K
Sbjct: 136 LLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLF 195
Query: 166 RKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMN 225
LKHPNII +GVC + P C++MEF G L VL +G+ + P +LV+W++ IA GMN
Sbjct: 196 AMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL-SGKRIPPDILVNWAVQIARGMN 254
Query: 226 YLH---LHKIIHRDLKSPNMLITY--------DDVVKISDFGTSKELSDKSTKMSFAGTV 274
YLH + IIHRDLKS N+LI + ++KI+DFG ++E ++TKMS AGT
Sbjct: 255 YLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWH-RTTKMSAAGTY 313
Query: 275 AWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSS 334
AWMAPEVIR S+ D+WS+GV+LWELLTGE+P++ +D A+ +GV N L LP+PS+
Sbjct: 314 AWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPST 373
Query: 335 CPDGFKILLRQCWNSKPRNRPSFRQILLHL-DIASADVLSTPQETYFKSQAEWREEVKLH 393
CP+ F L+ CWN P +RPSF IL L I + P++++ Q W+ E++
Sbjct: 374 CPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEM 433
Query: 394 FEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLER-ANNLYMELNALMLQLEL 452
F++++++ L EEEL ++ +R + ER + L ELN ++ QL
Sbjct: 434 FDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQ 493
Query: 453 KERELLRRE 461
++ + +R+
Sbjct: 494 EKPRVKKRK 502
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 242 bits (618), Expect = 9e-64
Identities = 156/441 (35%), Positives = 240/441 (54%), Gaps = 43/441 (9%)
Query: 120 VPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDI-----------KHLRKL 168
V FE + + +G+G G V+ + G+EVAVK R E D + L
Sbjct: 119 VAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAML 178
Query: 169 KHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVL--------------RAGRPVTPSLLV 214
+HPNII +GVC Q P C+++EF G L L R R + P +LV
Sbjct: 179 RHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLV 238
Query: 215 DWSMGIAGGMNYLHLHK---IIHRDLKSPNML----ITYDDV----VKISDFGTSKELSD 263
+W++ IA GM YLH I+HRDLKS N+L I +DD+ +KI+DFG ++E
Sbjct: 239 NWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWH- 297
Query: 264 KSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVG 323
++TKMS AGT AWMAPEVI++ S+ DIWS+GV+LWELLTGE+PY+ +D A+ +GV
Sbjct: 298 RTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVA 357
Query: 324 SNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLD-IASADVLSTPQETYFKS 382
N L LP+PS+CP+ F L+++CW P RPSF IL L I A + PQE++
Sbjct: 358 VNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSM 417
Query: 383 QAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLER-ANNLYM 441
Q +W+ E++ F++++++ L EEEL ++ ++ ++ ER + L
Sbjct: 418 QDDWKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAEREIDVLER 477
Query: 442 ELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKR--NVPQKL 499
ELN L+ QL ++ ++ +R+ +R L H R L + K+ + N+ ++
Sbjct: 478 ELNILIFQLNQEKPKVKKRKGKFKRSRLKLKDGH--RISLPSDFQHKITVQASPNLDKRR 535
Query: 500 SPHSKRPDILKTESLLPKLDA 520
S +S + +++P+L A
Sbjct: 536 SLNSSSSSPPSSPTMMPRLRA 556
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 213 bits (542), Expect = 6e-55
Identities = 120/306 (39%), Positives = 183/306 (59%), Gaps = 10/306 (3%)
Query: 119 EVPFEEILDLQWVGSGAQGAVFLGRF--HGEEVAVKKVRDLKETDIKHLRKLKHPNIITF 176
++ F+++ + G G+ G+V+ ++ +EVAVKK+ + E + + L L H NII F
Sbjct: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKI-EKEAEILSVLSHRNIIQF 68
Query: 177 KGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSL--LVDWSMGIAGGMNYLHLH---K 231
GV + P Y I+ E+ + G LY+ + + R + ++ W+ +A GM+YLH+ K
Sbjct: 69 YGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVK 128
Query: 232 IIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKV 291
+IHRDLKS N++I D V+KI DFG S+ + +T MS GT WMAPEVI++ PVSE
Sbjct: 129 VIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSLPVSETC 187
Query: 292 DIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKP 351
D +S+GVVLWE+LT E+P+K ++ + W V + L +PSSCP F LL QCW +
Sbjct: 188 DTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADA 247
Query: 352 RNRPSFRQILLHLDIASADV-LSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEE 410
+ RPSF+QI+ L+ S D L ++ ++AEWR E++ E++K L E+E
Sbjct: 248 KKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQE 307
Query: 411 LVMRRR 416
L R R
Sbjct: 308 LKERER 313
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 213 bits (542), Expect = 6e-55
Identities = 120/306 (39%), Positives = 183/306 (59%), Gaps = 10/306 (3%)
Query: 119 EVPFEEILDLQWVGSGAQGAVFLGRF--HGEEVAVKKVRDLKETDIKHLRKLKHPNIITF 176
++ F+++ + G G+ G+V+ ++ +EVAVKK+ + E + + L L H NII F
Sbjct: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKI-EKEAEILSVLSHRNIIQF 68
Query: 177 KGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSL--LVDWSMGIAGGMNYLHLH---K 231
GV + P Y I+ E+ + G LY+ + + R + ++ W+ +A GM+YLH+ K
Sbjct: 69 YGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVK 128
Query: 232 IIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKV 291
+IHRDLKS N++I D V+KI DFG S+ + +T MS GT WMAPEVI++ PVSE
Sbjct: 129 VIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSLPVSETC 187
Query: 292 DIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKP 351
D +S+GVVLWE+LT E+P+K ++ + W V + L +PSSCP F LL QCW +
Sbjct: 188 DTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADA 247
Query: 352 RNRPSFRQILLHLDIASADV-LSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEE 410
+ RPSF+QI+ L+ S D L ++ ++AEWR E++ E++K L E+E
Sbjct: 248 KKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQE 307
Query: 411 LVMRRR 416
L R R
Sbjct: 308 LKERER 313
>gi|33188459 B-Raf [Homo sapiens]
Length = 766
Score = 154 bits (390), Expect = 3e-37
Identities = 102/276 (36%), Positives = 151/276 (54%), Gaps = 22/276 (7%)
Query: 111 KQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKET---------D 161
++ D WE+P +I Q +GSG+ G V+ G++HG+ VAVK + T +
Sbjct: 443 RRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD-VAVKMLNVTAPTPQQLQAFKNE 501
Query: 162 IKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSL-LVDWSMGI 220
+ LRK +H NI+ F G T+ P I+ ++C LY L + L+D +
Sbjct: 502 VGVLRKTRHVNILLFMGYSTK-PQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQT 560
Query: 221 AGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSF---AGTVAWM 277
A GM+YLH IIHRDLKS N+ + D VKI DFG + S S F +G++ WM
Sbjct: 561 AQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWM 620
Query: 278 APEVIR---NEPVSEKVDIWSFGVVLWELLTGEIPYKDVDS-SAIIWGVGSNSLH---LP 330
APEVIR P S + D+++FG+VL+EL+TG++PY ++++ II+ VG L
Sbjct: 621 APEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSK 680
Query: 331 VPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDI 366
V S+CP K L+ +C K RP F QIL +++
Sbjct: 681 VRSNCPKAMKRLMAECLKKKRDERPLFPQILASIEL 716
>gi|21735566 mitogen-activated protein kinase kinase kinase 7
isoform D [Homo sapiens]
Length = 491
Score = 152 bits (383), Expect = 2e-36
Identities = 86/257 (33%), Positives = 140/257 (54%), Gaps = 19/257 (7%)
Query: 119 EVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKE-----TDIKHLRKLKHPNI 173
E+ ++EI + VG GA G V ++ ++VA+K++ E +++ L ++ HPNI
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
Query: 174 ITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPV---TPSLLVDWSMGIAGGMNYLHLH 230
+ G C C++ME+ G LY VL P+ T + + W + + G+ YLH
Sbjct: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
Query: 231 K---IIHRDLKSPNMLITYDD-VVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEP 286
+ +IHRDLK PN+L+ V+KI DFGT+ ++ T G+ AWMAPEV
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEVFEGSN 205
Query: 287 VSEKVDIWSFGVVLWELLTGEIPYKDVDSSA--IIWGVGSNSLHLPVPSSCPDGFKILLR 344
SEK D++S+G++LWE++T P+ ++ A I+W V N P+ + P + L+
Sbjct: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAV-HNGTRPPLIKNLPKPIESLMT 264
Query: 345 QCWNSKPRNRPSFRQIL 361
+CW+ P RPS +I+
Sbjct: 265 RCWSKDPSQRPSMEEIV 281
>gi|21735564 mitogen-activated protein kinase kinase kinase 7
isoform C [Homo sapiens]
Length = 518
Score = 152 bits (383), Expect = 2e-36
Identities = 86/257 (33%), Positives = 140/257 (54%), Gaps = 19/257 (7%)
Query: 119 EVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKE-----TDIKHLRKLKHPNI 173
E+ ++EI + VG GA G V ++ ++VA+K++ E +++ L ++ HPNI
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
Query: 174 ITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPV---TPSLLVDWSMGIAGGMNYLHLH 230
+ G C C++ME+ G LY VL P+ T + + W + + G+ YLH
Sbjct: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
Query: 231 K---IIHRDLKSPNMLITYDD-VVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEP 286
+ +IHRDLK PN+L+ V+KI DFGT+ ++ T G+ AWMAPEV
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEVFEGSN 205
Query: 287 VSEKVDIWSFGVVLWELLTGEIPYKDVDSSA--IIWGVGSNSLHLPVPSSCPDGFKILLR 344
SEK D++S+G++LWE++T P+ ++ A I+W V N P+ + P + L+
Sbjct: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAV-HNGTRPPLIKNLPKPIESLMT 264
Query: 345 QCWNSKPRNRPSFRQIL 361
+CW+ P RPS +I+
Sbjct: 265 RCWSKDPSQRPSMEEIV 281
>gi|21735562 mitogen-activated protein kinase kinase kinase 7
isoform B [Homo sapiens]
Length = 606
Score = 152 bits (383), Expect = 2e-36
Identities = 86/257 (33%), Positives = 140/257 (54%), Gaps = 19/257 (7%)
Query: 119 EVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKE-----TDIKHLRKLKHPNI 173
E+ ++EI + VG GA G V ++ ++VA+K++ E +++ L ++ HPNI
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
Query: 174 ITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPV---TPSLLVDWSMGIAGGMNYLHLH 230
+ G C C++ME+ G LY VL P+ T + + W + + G+ YLH
Sbjct: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
Query: 231 K---IIHRDLKSPNMLITYDD-VVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEP 286
+ +IHRDLK PN+L+ V+KI DFGT+ ++ T G+ AWMAPEV
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEVFEGSN 205
Query: 287 VSEKVDIWSFGVVLWELLTGEIPYKDVDSSA--IIWGVGSNSLHLPVPSSCPDGFKILLR 344
SEK D++S+G++LWE++T P+ ++ A I+W V N P+ + P + L+
Sbjct: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAV-HNGTRPPLIKNLPKPIESLMT 264
Query: 345 QCWNSKPRNRPSFRQIL 361
+CW+ P RPS +I+
Sbjct: 265 RCWSKDPSQRPSMEEIV 281
>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform
A [Homo sapiens]
Length = 579
Score = 152 bits (383), Expect = 2e-36
Identities = 86/257 (33%), Positives = 140/257 (54%), Gaps = 19/257 (7%)
Query: 119 EVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKE-----TDIKHLRKLKHPNI 173
E+ ++EI + VG GA G V ++ ++VA+K++ E +++ L ++ HPNI
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
Query: 174 ITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPV---TPSLLVDWSMGIAGGMNYLHLH 230
+ G C C++ME+ G LY VL P+ T + + W + + G+ YLH
Sbjct: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
Query: 231 K---IIHRDLKSPNMLITYDD-VVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEP 286
+ +IHRDLK PN+L+ V+KI DFGT+ ++ T G+ AWMAPEV
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEVFEGSN 205
Query: 287 VSEKVDIWSFGVVLWELLTGEIPYKDVDSSA--IIWGVGSNSLHLPVPSSCPDGFKILLR 344
SEK D++S+G++LWE++T P+ ++ A I+W V N P+ + P + L+
Sbjct: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAV-HNGTRPPLIKNLPKPIESLMT 264
Query: 345 QCWNSKPRNRPSFRQIL 361
+CW+ P RPS +I+
Sbjct: 265 RCWSKDPSQRPSMEEIV 281
>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 148 bits (373), Expect = 2e-35
Identities = 91/261 (34%), Positives = 147/261 (56%), Gaps = 14/261 (5%)
Query: 117 LWEVPFEEILDLQWVGSGAQGAVFLGRFHGE-EVAVKKVRD--LKETDI----KHLRKLK 169
+WE+ EEI L+ +GSG G V LG++ G+ +VAVK +++ + E + + + KL
Sbjct: 409 IWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLS 468
Query: 170 HPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRA-GRPVTPSLLVDWSMGIAGGMNYLH 228
HP ++ F GVC++ I+ E+ + G L LR+ G+ + PS L++ + GM +L
Sbjct: 469 HPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLE 528
Query: 229 LHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGT---VAWMAPEVIRNE 285
H+ IHRDL + N L+ D VK+SDFG ++ + D +S GT V W APEV
Sbjct: 529 SHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLD-DQYVSSVGTKFPVKWSAPEVFHYF 587
Query: 286 PVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLR 344
S K D+W+FG+++WE+ + G+ PY D+S ++ V S L P D ++
Sbjct: 588 KYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKV-SQGHRLYRPHLASDTIYQIMY 646
Query: 345 QCWNSKPRNRPSFRQILLHLD 365
CW+ P RP+F+Q+L ++
Sbjct: 647 SCWHELPEKRPTFQQLLSSIE 667
>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 148 bits (373), Expect = 2e-35
Identities = 91/261 (34%), Positives = 147/261 (56%), Gaps = 14/261 (5%)
Query: 117 LWEVPFEEILDLQWVGSGAQGAVFLGRFHGE-EVAVKKVRD--LKETDI----KHLRKLK 169
+WE+ EEI L+ +GSG G V LG++ G+ +VAVK +++ + E + + + KL
Sbjct: 409 IWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLS 468
Query: 170 HPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRA-GRPVTPSLLVDWSMGIAGGMNYLH 228
HP ++ F GVC++ I+ E+ + G L LR+ G+ + PS L++ + GM +L
Sbjct: 469 HPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLE 528
Query: 229 LHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGT---VAWMAPEVIRNE 285
H+ IHRDL + N L+ D VK+SDFG ++ + D +S GT V W APEV
Sbjct: 529 SHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLD-DQYVSSVGTKFPVKWSAPEVFHYF 587
Query: 286 PVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLR 344
S K D+W+FG+++WE+ + G+ PY D+S ++ V S L P D ++
Sbjct: 588 KYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKV-SQGHRLYRPHLASDTIYQIMY 646
Query: 345 QCWNSKPRNRPSFRQILLHLD 365
CW+ P RP+F+Q+L ++
Sbjct: 647 SCWHELPEKRPTFQQLLSSIE 667
>gi|4502193 v-raf murine sarcoma 3611 viral oncogene homolog [Homo
sapiens]
Length = 606
Score = 145 bits (365), Expect = 2e-34
Identities = 102/273 (37%), Positives = 148/273 (54%), Gaps = 30/273 (10%)
Query: 118 WEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKET---------DIKHLRKL 168
WEVP E+ L+ +G+G+ G VF GR+HG+ VAVK ++ + T +++ LRK
Sbjct: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD-VAVKVLKVSQPTAEQAQAFKNEMQVLRKT 361
Query: 169 KHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLR-AGRPVTPSLLVDWSMGIAGGMNYL 227
+H NI+ F G T+ P + I+ ++C LY L A L+D + A GM+YL
Sbjct: 362 RHVNILLFMGFMTR-PGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL 420
Query: 228 HLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFA-------GTVAWMAPE 280
H IIHRDLKS N+ + VKI DFG L+ T+ S A G+V WMA E
Sbjct: 421 HAKNIIHRDLKSNNIFLHEGLTVKIGDFG----LATVKTRWSGAQPLEQPSGSVLWMAAE 476
Query: 281 VIRNE---PVSEKVDIWSFGVVLWELLTGEIPYKDVD-SSAIIWGVGSNSLH---LPVPS 333
VIR + P S + D++++GVVL+EL+TG +PY + II+ VG L + S
Sbjct: 477 VIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISS 536
Query: 334 SCPDGFKILLRQCWNSKPRNRPSFRQILLHLDI 366
+CP + LL C + RP F QIL +++
Sbjct: 537 NCPKAMRRLLSDCLKFQREERPLFPQILATIEL 569
>gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]
Length = 694
Score = 141 bits (356), Expect = 2e-33
Identities = 95/270 (35%), Positives = 129/270 (47%), Gaps = 16/270 (5%)
Query: 110 HKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEE--VAVKKVRDLKETDIKH--- 164
H+ +D W + E+++ + +G G G VF GR + VAVK R+ D+K
Sbjct: 418 HRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFL 477
Query: 165 -----LRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRA-GRPVTPSLLVDWSM 218
L++ HPNI+ GVCTQ I+ME G LR G + L+
Sbjct: 478 QEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVG 537
Query: 219 GIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFA---GTVA 275
A GM YL IHRDL + N L+T +V+KISDFG S+E +D S V
Sbjct: 538 DAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVK 597
Query: 276 WMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSS 334
W APE + S + D+WSFG++LWE + G PY ++ + V LP P
Sbjct: 598 WTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGG-RLPCPEL 656
Query: 335 CPDGFKILLRQCWNSKPRNRPSFRQILLHL 364
CPD L+ QCW +P RPSF I L
Sbjct: 657 CPDAVFRLMEQCWAYEPGQRPSFSTIYQEL 686
>gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]
Length = 752
Score = 141 bits (356), Expect = 2e-33
Identities = 95/270 (35%), Positives = 129/270 (47%), Gaps = 16/270 (5%)
Query: 110 HKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEE--VAVKKVRDLKETDIKH--- 164
H+ +D W + E+++ + +G G G VF GR + VAVK R+ D+K
Sbjct: 476 HRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFL 535
Query: 165 -----LRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRA-GRPVTPSLLVDWSM 218
L++ HPNI+ GVCTQ I+ME G LR G + L+
Sbjct: 536 QEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVG 595
Query: 219 GIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFA---GTVA 275
A GM YL IHRDL + N L+T +V+KISDFG S+E +D S V
Sbjct: 596 DAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVK 655
Query: 276 WMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSS 334
W APE + S + D+WSFG++LWE + G PY ++ + V LP P
Sbjct: 656 WTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGG-RLPCPEL 714
Query: 335 CPDGFKILLRQCWNSKPRNRPSFRQILLHL 364
CPD L+ QCW +P RPSF I L
Sbjct: 715 CPDAVFRLMEQCWAYEPGQRPSFSTIYQEL 744
>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
Length = 764
Score = 141 bits (356), Expect = 2e-33
Identities = 95/270 (35%), Positives = 129/270 (47%), Gaps = 16/270 (5%)
Query: 110 HKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEE--VAVKKVRDLKETDIKH--- 164
H+ +D W + E+++ + +G G G VF GR + VAVK R+ D+K
Sbjct: 488 HRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFL 547
Query: 165 -----LRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRA-GRPVTPSLLVDWSM 218
L++ HPNI+ GVCTQ I+ME G LR G + L+
Sbjct: 548 QEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVG 607
Query: 219 GIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFA---GTVA 275
A GM YL IHRDL + N L+T +V+KISDFG S+E +D S V
Sbjct: 608 DAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVK 667
Query: 276 WMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSS 334
W APE + S + D+WSFG++LWE + G PY ++ + V LP P
Sbjct: 668 WTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGG-RLPCPEL 726
Query: 335 CPDGFKILLRQCWNSKPRNRPSFRQILLHL 364
CPD L+ QCW +P RPSF I L
Sbjct: 727 CPDAVFRLMEQCWAYEPGQRPSFSTIYQEL 756
>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
Length = 822
Score = 141 bits (356), Expect = 2e-33
Identities = 95/270 (35%), Positives = 129/270 (47%), Gaps = 16/270 (5%)
Query: 110 HKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEE--VAVKKVRDLKETDIKH--- 164
H+ +D W + E+++ + +G G G VF GR + VAVK R+ D+K
Sbjct: 546 HRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFL 605
Query: 165 -----LRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRA-GRPVTPSLLVDWSM 218
L++ HPNI+ GVCTQ I+ME G LR G + L+
Sbjct: 606 QEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVG 665
Query: 219 GIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFA---GTVA 275
A GM YL IHRDL + N L+T +V+KISDFG S+E +D S V
Sbjct: 666 DAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVK 725
Query: 276 WMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSS 334
W APE + S + D+WSFG++LWE + G PY ++ + V LP P
Sbjct: 726 WTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGG-RLPCPEL 784
Query: 335 CPDGFKILLRQCWNSKPRNRPSFRQILLHL 364
CPD L+ QCW +P RPSF I L
Sbjct: 785 CPDAVFRLMEQCWAYEPGQRPSFSTIYQEL 814
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 141 bits (355), Expect = 3e-33
Identities = 86/259 (33%), Positives = 140/259 (54%), Gaps = 16/259 (6%)
Query: 118 WEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRD-------LKETDIKHLRKLKH 170
W + +E+ LQ +G G G V LG + G +VAVK +++ L E + + +L+H
Sbjct: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASV--MTQLRH 245
Query: 171 PNIITFKGVCTQAPC-YCILMEFCAQGQLYEVLRA-GRPVTPS-LLVDWSMGIAGGMNYL 227
N++ GV + I+ E+ A+G L + LR+ GR V L+ +S+ + M YL
Sbjct: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305
Query: 228 HLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPV 287
+ +HRDL + N+L++ D+V K+SDFG +KE S ST+ + V W APE +R +
Sbjct: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS--STQDTGKLPVKWTAPEALREKKF 363
Query: 288 SEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQC 346
S K D+WSFG++LWE+ + G +PY + ++ V + P CP +++ C
Sbjct: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV-EKGYKMDAPDGCPPAVYEVMKNC 422
Query: 347 WNSKPRNRPSFRQILLHLD 365
W+ RPSF Q+ L+
Sbjct: 423 WHLDAAMRPSFLQLREQLE 441
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 141 bits (355), Expect = 3e-33
Identities = 86/259 (33%), Positives = 140/259 (54%), Gaps = 16/259 (6%)
Query: 118 WEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRD-------LKETDIKHLRKLKH 170
W + +E+ LQ +G G G V LG + G +VAVK +++ L E + + +L+H
Sbjct: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASV--MTQLRH 245
Query: 171 PNIITFKGVCTQAPC-YCILMEFCAQGQLYEVLRA-GRPVTPS-LLVDWSMGIAGGMNYL 227
N++ GV + I+ E+ A+G L + LR+ GR V L+ +S+ + M YL
Sbjct: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305
Query: 228 HLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPV 287
+ +HRDL + N+L++ D+V K+SDFG +KE S ST+ + V W APE +R +
Sbjct: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS--STQDTGKLPVKWTAPEALREKKF 363
Query: 288 SEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQC 346
S K D+WSFG++LWE+ + G +PY + ++ V + P CP +++ C
Sbjct: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV-EKGYKMDAPDGCPPAVYEVMKNC 422
Query: 347 WNSKPRNRPSFRQILLHLD 365
W+ RPSF Q+ L+
Sbjct: 423 WHLDAAMRPSFLQLREQLE 441
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 141 bits (355), Expect = 3e-33
Identities = 87/267 (32%), Positives = 141/267 (52%), Gaps = 20/267 (7%)
Query: 116 DLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEE-VAVKKVRD--------LKETDIKHLR 166
D WE+ I L+ +GSG G V+ G ++ VAVK ++ L+E I ++
Sbjct: 225 DQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQI--MK 282
Query: 167 KLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLR--AGRPVTPSLLVDWSMGIAGGM 224
L+HP +I VCT I+ E G L E L+ G + + VD + +A GM
Sbjct: 283 NLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGM 342
Query: 225 NYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKS-----TKMSFAGTVAWMAP 279
YL IHRDL + N+L+ ++ K++DFG ++ + ++ V W AP
Sbjct: 343 AYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAP 402
Query: 280 EVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDG 338
E IR+ S K D+WSFG++L+E++T G++PY + + +I + N LP PS+CP
Sbjct: 403 EAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQN-YRLPQPSNCPQQ 461
Query: 339 FKILLRQCWNSKPRNRPSFRQILLHLD 365
F ++ +CWN++P+ RP+F + L+
Sbjct: 462 FYNIMLECWNAEPKERPTFETLRWKLE 488
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 139 bits (351), Expect = 9e-33
Identities = 111/343 (32%), Positives = 163/343 (47%), Gaps = 58/343 (16%)
Query: 61 AAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEV 120
+ S +S +S VR VRL SG L GL P+ + LWE
Sbjct: 382 SGSSGKSSSSLVRG--VRLS-SSGPALLAGLVSLDLPL----------------DPLWEF 422
Query: 121 PFEEILDLQWVGSGAQGAVFLGRFHGEE---------VAVKKVRD-LKETDIKHL----- 165
P + ++ + +G G G V G + VAVK ++D + D+ L
Sbjct: 423 PRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEME 482
Query: 166 -RKL--KHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSL---------- 212
KL +H NII GVCTQ +++E A+G L E LRA RP P L
Sbjct: 483 VMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEG 542
Query: 213 ------LVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELS--DK 264
LV + +A GM YL K IHRDL + N+L+T D+V+KI+DFG ++ + D
Sbjct: 543 PLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDY 602
Query: 265 STKMSFAG-TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGV 322
K S V WMAPE + + + + D+WSFG++LWE+ T G PY + ++ +
Sbjct: 603 YKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEE-LFSL 661
Query: 323 GSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLD 365
+ P CP L+R+CW++ P RP+F+Q++ LD
Sbjct: 662 LREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALD 704
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 139 bits (351), Expect = 9e-33
Identities = 111/343 (32%), Positives = 163/343 (47%), Gaps = 58/343 (16%)
Query: 61 AAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEV 120
+ S +S +S VR VRL SG L GL P+ + LWE
Sbjct: 422 SGSSGKSSSSLVRG--VRLS-SSGPALLAGLVSLDLPL----------------DPLWEF 462
Query: 121 PFEEILDLQWVGSGAQGAVFLGRFHGEE---------VAVKKVRD-LKETDIKHL----- 165
P + ++ + +G G G V G + VAVK ++D + D+ L
Sbjct: 463 PRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEME 522
Query: 166 -RKL--KHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSL---------- 212
KL +H NII GVCTQ +++E A+G L E LRA RP P L
Sbjct: 523 VMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEG 582
Query: 213 ------LVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELS--DK 264
LV + +A GM YL K IHRDL + N+L+T D+V+KI+DFG ++ + D
Sbjct: 583 PLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDY 642
Query: 265 STKMSFAG-TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGV 322
K S V WMAPE + + + + D+WSFG++LWE+ T G PY + ++ +
Sbjct: 643 YKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEE-LFSL 701
Query: 323 GSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLD 365
+ P CP L+R+CW++ P RP+F+Q++ LD
Sbjct: 702 LREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALD 744
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 139 bits (351), Expect = 9e-33
Identities = 111/343 (32%), Positives = 163/343 (47%), Gaps = 58/343 (16%)
Query: 61 AAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEV 120
+ S +S +S VR VRL SG L GL P+ + LWE
Sbjct: 422 SGSSGKSSSSLVRG--VRLS-SSGPALLAGLVSLDLPL----------------DPLWEF 462
Query: 121 PFEEILDLQWVGSGAQGAVFLGRFHGEE---------VAVKKVRD-LKETDIKHL----- 165
P + ++ + +G G G V G + VAVK ++D + D+ L
Sbjct: 463 PRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEME 522
Query: 166 -RKL--KHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSL---------- 212
KL +H NII GVCTQ +++E A+G L E LRA RP P L
Sbjct: 523 VMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEG 582
Query: 213 ------LVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELS--DK 264
LV + +A GM YL K IHRDL + N+L+T D+V+KI+DFG ++ + D
Sbjct: 583 PLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDY 642
Query: 265 STKMSFAG-TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGV 322
K S V WMAPE + + + + D+WSFG++LWE+ T G PY + ++ +
Sbjct: 643 YKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEE-LFSL 701
Query: 323 GSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLD 365
+ P CP L+R+CW++ P RP+F+Q++ LD
Sbjct: 702 LREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALD 744
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 139 bits (351), Expect = 9e-33
Identities = 87/264 (32%), Positives = 140/264 (53%), Gaps = 20/264 (7%)
Query: 111 KQQQEDL----WEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRD-------LKE 159
K +E+L W + + + +G G GAV G + G++VAVK ++ L E
Sbjct: 176 KSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDE 235
Query: 160 TDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRA-GRP-VTPSLLVDWS 217
T + + K++H N++ GV Y I+ME ++G L LR GR V + L+ +S
Sbjct: 236 TAV--MTKMQHENLVRLLGVILHQGLY-IVMEHVSKGNLVNFLRTRGRALVNTAQLLQFS 292
Query: 218 MGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWM 277
+ +A GM YL K++HRDL + N+L++ D V K+SDFG +K +++ S V W
Sbjct: 293 LHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAK--AERKGLDSSRLPVKWT 350
Query: 278 APEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSSCP 336
APE +++ + K D+WSFGV+LWE+ + G PY + + V + P CP
Sbjct: 351 APEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAV-EKGYRMEPPEGCP 409
Query: 337 DGFKILLRQCWNSKPRNRPSFRQI 360
+L+ CW ++P RP FR++
Sbjct: 410 GPVHVLMSSCWEAEPARRPPFRKL 433
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 139 bits (351), Expect = 9e-33
Identities = 87/264 (32%), Positives = 140/264 (53%), Gaps = 20/264 (7%)
Query: 111 KQQQEDL----WEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRD-------LKE 159
K +E+L W + + + +G G GAV G + G++VAVK ++ L E
Sbjct: 218 KSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDE 277
Query: 160 TDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRA-GRP-VTPSLLVDWS 217
T + + K++H N++ GV Y I+ME ++G L LR GR V + L+ +S
Sbjct: 278 TAV--MTKMQHENLVRLLGVILHQGLY-IVMEHVSKGNLVNFLRTRGRALVNTAQLLQFS 334
Query: 218 MGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWM 277
+ +A GM YL K++HRDL + N+L++ D V K+SDFG +K +++ S V W
Sbjct: 335 LHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAK--AERKGLDSSRLPVKWT 392
Query: 278 APEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSSCP 336
APE +++ + K D+WSFGV+LWE+ + G PY + + V + P CP
Sbjct: 393 APEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAV-EKGYRMEPPEGCP 451
Query: 337 DGFKILLRQCWNSKPRNRPSFRQI 360
+L+ CW ++P RP FR++
Sbjct: 452 GPVHVLMSSCWEAEPARRPPFRKL 475
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 139 bits (351), Expect = 9e-33
Identities = 87/264 (32%), Positives = 140/264 (53%), Gaps = 20/264 (7%)
Query: 111 KQQQEDL----WEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRD-------LKE 159
K +E+L W + + + +G G GAV G + G++VAVK ++ L E
Sbjct: 217 KSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDE 276
Query: 160 TDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRA-GRP-VTPSLLVDWS 217
T + + K++H N++ GV Y I+ME ++G L LR GR V + L+ +S
Sbjct: 277 TAV--MTKMQHENLVRLLGVILHQGLY-IVMEHVSKGNLVNFLRTRGRALVNTAQLLQFS 333
Query: 218 MGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWM 277
+ +A GM YL K++HRDL + N+L++ D V K+SDFG +K +++ S V W
Sbjct: 334 LHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAK--AERKGLDSSRLPVKWT 391
Query: 278 APEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSSCP 336
APE +++ + K D+WSFGV+LWE+ + G PY + + V + P CP
Sbjct: 392 APEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAV-EKGYRMEPPEGCP 450
Query: 337 DGFKILLRQCWNSKPRNRPSFRQI 360
+L+ CW ++P RP FR++
Sbjct: 451 GPVHVLMSSCWEAEPARRPPFRKL 474
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 139 bits (349), Expect = 1e-32
Identities = 88/261 (33%), Positives = 136/261 (52%), Gaps = 20/261 (7%)
Query: 116 DLWEVPFEEILDLQWVGSGAQGAVFLG--RFHGEEVAVKKVRD--------LKETDIKHL 165
D WE+ +I +G G G V+ G + + VAVK +++ LKE + +
Sbjct: 233 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAV--M 290
Query: 166 RKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRA--GRPVTPSLLVDWSMGIAGG 223
+++KHPN++ GVCT+ P + I+ EF G L + LR + V +L+ + I+
Sbjct: 291 KEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSA 350
Query: 224 MNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGT---VAWMAPE 280
M YL IHRDL + N L+ + +VK++DFG S+ L T + AG + W APE
Sbjct: 351 MEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR-LMTGDTYTAHAGAKFPIKWTAPE 409
Query: 281 VIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGF 339
+ S K D+W+FGV+LWE+ T G PY +D S ++ + + P CP+
Sbjct: 410 SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ-VYELLEKDYRMERPEGCPEKV 468
Query: 340 KILLRQCWNSKPRNRPSFRQI 360
L+R CW P +RPSF +I
Sbjct: 469 YELMRACWQWNPSDRPSFAEI 489
Score = 36.2 bits (82), Expect = 0.13
Identities = 37/144 (25%), Positives = 49/144 (34%), Gaps = 35/144 (24%)
Query: 547 HRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKM 606
H++ + KGS P V P G G+PGG GP+ + K
Sbjct: 832 HKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAE-----------ESRVRRHKH 880
Query: 607 SSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPG----GAK 662
SS SP R +G P PPP + G S S ++ G GAK
Sbjct: 881 SSESP--------GRDKGKLSRL-KPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAK 931
Query: 663 -----------GEPPPPVGPGEGV 675
+ P PGEG+
Sbjct: 932 TKATSLVDAVNSDAAKPSQPGEGL 955
Score = 35.8 bits (81), Expect = 0.17
Identities = 42/160 (26%), Positives = 55/160 (34%), Gaps = 21/160 (13%)
Query: 516 PKLDAALSGVGLPG-CPKAPPSPGRSRRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGP 574
P + +G G PG K P R RR K H S G L L+ A PP
Sbjct: 850 PVTPTSKAGSGAPGGTSKGPAEESRVRRHK--HSSESPGRDKGKLSRLKPAPPPPPAASA 907
Query: 575 GSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRGRGATGGAG---- 630
G GG + EA A+ G + + L+ A + + G G
Sbjct: 908 GKAGGKPSQSPSQEAAGEAVLG---------AKTKATSLVDAVNSDAAKPSQPGEGLKKP 958
Query: 631 -DPGSPPPAR---GDTPPSEGSAPGSTSPDSPGGAKGEPP 666
P +P P TP S P ST P + G+ P
Sbjct: 959 VLPATPKPQSAKPSGTPISPAPVP-STLPSASSALAGDQP 997
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.133 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,809,378
Number of Sequences: 37866
Number of extensions: 2786020
Number of successful extensions: 33751
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 998
Number of HSP's successfully gapped in prelim test: 1472
Number of HSP's that attempted gapping in prelim test: 14815
Number of HSP's gapped (non-prelim): 9613
length of query: 859
length of database: 18,247,518
effective HSP length: 111
effective length of query: 748
effective length of database: 14,044,392
effective search space: 10505205216
effective search space used: 10505205216
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.