Guide to the Human Genome
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Search of human proteins with 217272802

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|217272802 hyaluronan-mediated motility receptor isoform a
[Homo sapiens]
         (725 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|217272802 hyaluronan-mediated motility receptor isoform a [Ho...  1389   0.0  
gi|217416394 hyaluronan-mediated motility receptor isoform b [Ho...  1382   0.0  
gi|217416398 hyaluronan-mediated motility receptor isoform c [Ho...  1348   0.0  
gi|217272804 hyaluronan-mediated motility receptor isoform d [Ho...  1211   0.0  
gi|9910266 kinesin family member 15 [Homo sapiens]                    133   5e-31
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]        127   4e-29
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    125   1e-28
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]   124   3e-28
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...   123   7e-28
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   122   9e-28
gi|156104908 myosin heavy chain 6 [Homo sapiens]                      122   2e-27
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    120   3e-27
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...   119   1e-26
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...   117   4e-26
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...   117   5e-26
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...   117   5e-26
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...   116   6e-26
gi|4885583 Rho-associated, coiled-coil containing protein kinase...   116   8e-26
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...   116   8e-26
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...   116   8e-26
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...   115   1e-25
gi|21735548 centrosomal protein 2 [Homo sapiens]                      114   2e-25
gi|32698688 citron [Homo sapiens]                                     114   2e-25
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...   114   2e-25
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]               114   3e-25
gi|87298937 centrosomal protein 110kDa [Homo sapiens]                 114   4e-25
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   113   5e-25
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   113   5e-25
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   113   5e-25
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   113   5e-25

>gi|217272802 hyaluronan-mediated motility receptor isoform a [Homo
           sapiens]
          Length = 725

 Score = 1389 bits (3595), Expect = 0.0
 Identities = 725/725 (100%), Positives = 725/725 (100%)

Query: 1   MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT 60
           MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT
Sbjct: 1   MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT 60

Query: 61  TLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARL 120
           TLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARL
Sbjct: 61  TLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARL 120

Query: 121 NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET 180
           NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET
Sbjct: 121 NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET 180

Query: 181 KMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE 240
           KMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE
Sbjct: 181 KMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE 240

Query: 241 ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE 300
           ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE
Sbjct: 241 ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE 300

Query: 301 KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 360
           KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK
Sbjct: 301 KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 360

Query: 361 LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 420
           LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK
Sbjct: 361 LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 420

Query: 421 LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS 480
           LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS
Sbjct: 421 LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS 480

Query: 481 LQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 540
           LQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD
Sbjct: 481 LQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 540

Query: 541 LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA 600
           LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA
Sbjct: 541 LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA 600

Query: 601 FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR 660
           FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR
Sbjct: 601 FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR 660

Query: 661 CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMEC 720
           CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMEC
Sbjct: 661 CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMEC 720

Query: 721 QESWK 725
           QESWK
Sbjct: 721 QESWK 725


>gi|217416394 hyaluronan-mediated motility receptor isoform b [Homo
           sapiens]
          Length = 724

 Score = 1382 bits (3578), Expect = 0.0
 Identities = 724/725 (99%), Positives = 724/725 (99%), Gaps = 1/725 (0%)

Query: 1   MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT 60
           MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT
Sbjct: 1   MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT 60

Query: 61  TLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARL 120
           TLPASARKVKSSESK ESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARL
Sbjct: 61  TLPASARKVKSSESK-ESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARL 119

Query: 121 NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET 180
           NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET
Sbjct: 120 NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET 179

Query: 181 KMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE 240
           KMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE
Sbjct: 180 KMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE 239

Query: 241 ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE 300
           ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE
Sbjct: 240 ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE 299

Query: 301 KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 360
           KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK
Sbjct: 300 KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 359

Query: 361 LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 420
           LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK
Sbjct: 360 LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 419

Query: 421 LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS 480
           LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS
Sbjct: 420 LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS 479

Query: 481 LQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 540
           LQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD
Sbjct: 480 LQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 539

Query: 541 LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA 600
           LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA
Sbjct: 540 LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA 599

Query: 601 FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR 660
           FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR
Sbjct: 600 FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR 659

Query: 661 CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMEC 720
           CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMEC
Sbjct: 660 CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMEC 719

Query: 721 QESWK 725
           QESWK
Sbjct: 720 QESWK 724


>gi|217416398 hyaluronan-mediated motility receptor isoform c [Homo
           sapiens]
          Length = 709

 Score = 1348 bits (3489), Expect = 0.0
 Identities = 709/725 (97%), Positives = 709/725 (97%), Gaps = 16/725 (2%)

Query: 1   MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT 60
           MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT
Sbjct: 1   MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT 60

Query: 61  TLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARL 120
           TLPASARKVKSSESK                IRVLLQERGAQDRRIQDLETELEKMEARL
Sbjct: 61  TLPASARKVKSSESK----------------IRVLLQERGAQDRRIQDLETELEKMEARL 104

Query: 121 NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET 180
           NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET
Sbjct: 105 NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET 164

Query: 181 KMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE 240
           KMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE
Sbjct: 165 KMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE 224

Query: 241 ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE 300
           ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE
Sbjct: 225 ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE 284

Query: 301 KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 360
           KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK
Sbjct: 285 KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 344

Query: 361 LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 420
           LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK
Sbjct: 345 LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 404

Query: 421 LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS 480
           LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS
Sbjct: 405 LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS 464

Query: 481 LQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 540
           LQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD
Sbjct: 465 LQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 524

Query: 541 LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA 600
           LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA
Sbjct: 525 LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA 584

Query: 601 FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR 660
           FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR
Sbjct: 585 FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR 644

Query: 661 CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMEC 720
           CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMEC
Sbjct: 645 CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMEC 704

Query: 721 QESWK 725
           QESWK
Sbjct: 705 QESWK 709


>gi|217272804 hyaluronan-mediated motility receptor isoform d [Homo
           sapiens]
          Length = 638

 Score = 1211 bits (3132), Expect = 0.0
 Identities = 634/634 (100%), Positives = 634/634 (100%)

Query: 92  IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL 151
           IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL
Sbjct: 5   IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL 64

Query: 152 KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA 211
           KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA
Sbjct: 65  KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA 124

Query: 212 QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS 271
           QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS
Sbjct: 125 QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS 184

Query: 272 LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ 331
           LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ
Sbjct: 185 LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ 244

Query: 332 EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQ 391
           EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQ
Sbjct: 245 EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQ 304

Query: 392 KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 451
           KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ
Sbjct: 305 KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 364

Query: 452 SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR 511
           SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR
Sbjct: 365 SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR 424

Query: 512 MLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA 571
           MLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA
Sbjct: 425 MLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA 484

Query: 572 ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG 631
           ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG
Sbjct: 485 ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG 544

Query: 632 HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKA 691
           HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKA
Sbjct: 545 HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKA 604

Query: 692 FHHESKENFALKTPLKEGNTNCYRAPMECQESWK 725
           FHHESKENFALKTPLKEGNTNCYRAPMECQESWK
Sbjct: 605 FHHESKENFALKTPLKEGNTNCYRAPMECQESWK 638



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 103/467 (22%), Positives = 191/467 (40%), Gaps = 99/467 (21%)

Query: 40  KSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQER 99
           K Q  +++KE   N N + +  L A  + +K                ILE++ R  LQ++
Sbjct: 206 KCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKF-------------ILEQQEREKLQQK 252

Query: 100 GAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENG 159
             Q          L + E  L+++L +K          EK L E     E LK       
Sbjct: 253 ELQ-------IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFE-----EELKQTLD--- 297

Query: 160 NQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVS 219
                     EL KL+ K E   R +   +E  + + +  +   E+ +GK A+LE    +
Sbjct: 298 ----------ELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAA 347

Query: 220 IEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEEN 279
             +  +  + + + +++ +E+++    Q E YK   A   E+LK +N        SL+E 
Sbjct: 348 HTQATLLLQEKYDSMVQSLEDVTA---QFESYKALTASEIEDLKLEN-------SSLQEK 397

Query: 280 IVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK 339
                K  ED+  +    E   +++V                   + +L+ Q +  L++ 
Sbjct: 398 AAKAGKNAEDVQHQILATESSNQEYV-------------------RMLLDLQTKSALKET 438

Query: 340 ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL 399
           E+         KE++ S  QK+   Q ++ +++  F ++L+   DE  +  +KE     L
Sbjct: 439 EI---------KEITVSFLQKITDLQNQLKQQEEDFRKQLE---DEEGRKAEKENTTAEL 486

Query: 400 VKQ------LEEEAKSRAEELKL-LEEKLKGKEAELEKSSAAHTQ--------ATLL--- 441
            ++      L EE  ++ +  +L L+     K+A L +  AA  Q        A LL   
Sbjct: 487 TEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQ 546

Query: 442 -LQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAK 487
            L++K   +V+ L+D  +Q +S  +    ++   K   + LQE+  K
Sbjct: 547 NLKQKIKHVVK-LKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNK 592



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 73/357 (20%), Positives = 152/357 (42%), Gaps = 46/357 (12%)

Query: 39  QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQE 98
           QK   F+++   ++NL  ++         K++  E + E     + +K LE+E +   +E
Sbjct: 272 QKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAE-----RLVKQLEEEAKSRAEE 326

Query: 99  RGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSEN 158
               + +++  E ELEK     +AA  + T L      L+++   + ++ E + ++F   
Sbjct: 327 LKLLEEKLKGKEAELEKS----SAAHTQATLL------LQEKYDSMVQSLEDVTAQFE-- 374

Query: 159 GNQKNLRILSLELMKLRNKRETKMRGMMAKQ-EGMEMKLQVTQRSLEESQGKIAQLEGKL 217
            + K L    +E +KL N    +      K  E ++ ++  T+ S +E    +  L+   
Sbjct: 375 -SYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQ--- 430

Query: 218 VSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDI-----------AQLEENLKEKN 266
               K  + E    E  + ++++I+   +Q+++ + D            A+ E    E  
Sbjct: 431 ---TKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELT 487

Query: 267 DEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKF 326
           +EI   +   EE    L  + +   ++    E EK+  +N +    E LN ++++   K 
Sbjct: 488 EEINKWRLLYEE----LYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLN-KIRDSYAKL 542

Query: 327 ILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL 383
           +  Q     L+QK   +  L  +  +L S + +  C   ++   E  L +EEL + L
Sbjct: 543 LGHQ----NLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKL-QEELNKVL 594


>gi|9910266 kinesin family member 15 [Homo sapiens]
          Length = 1388

 Score =  133 bits (335), Expect = 5e-31
 Identities = 157/680 (23%), Positives = 305/680 (44%), Gaps = 80/680 (11%)

Query: 45   KQQKESKQNLNVDKDTTLPASARKVKSSES---KKESQKNDKDLKILEKEIRVLLQERGA 101
            ++ K  K   +VDK        +++ SSE     K+ ++    L +LEK+++    +   
Sbjct: 736  EEHKNLKLQQHVDKLEHHSTQMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDF 795

Query: 102  QDRRIQDLETELEKMEARLNAALREKTS-----------LSANNATLEKQLIELTRTNE- 149
                + DL   L   +  L++   E +S           LS  +  ++ QL  L   NE 
Sbjct: 796  LKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLENEK 855

Query: 150  LLKSKFSENGNQKNLRILSLELMKLR-NKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG 208
            LL+SK     +  NL+    E+MK   ++    ++    + E ++  L      LE  + 
Sbjct: 856  LLESKACLQDSYDNLQ----EIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKE 911

Query: 209  KIAQLEGKLVSIEKEKIDEKSETEKLLEYI-EEISCASDQVEKYKLDIAQLEENLKEKND 267
            +  +L    +  E++K +   E  K+LE + +E    + + E+    + +LEE+L     
Sbjct: 912  RNNKLS---LQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEK 968

Query: 268  EILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKF- 326
             I SL++S + +     K V DL  + Q    E    V    E  + L  E++++  K+ 
Sbjct: 969  VISSLEKSRDSD----KKVVADLMNQIQ----ELRTSVCEKTETIDTLKQELKDINCKYN 1020

Query: 327  -ILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDE 385
              L  +E  ++  K+ ++D L     +L  +L  ++ S  E++  E+++  E+L    ++
Sbjct: 1021 SALVDREESRVLIKKQEVDIL-----DLKETLRLRILS--EDI--ERDMLCEDLAHATEQ 1071

Query: 386  LDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEK 445
            L+ L +  ++   L++  +EE   +   ++ L+ KL  K+ E+E+    +      L+  
Sbjct: 1072 LNMLTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHV 1131

Query: 446  YDSMVQSLED--VTAQFESYKA----LTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI 499
             DS  +  +       F+++ A        EIED +   +SL+    K  ++ E    +I
Sbjct: 1132 MDSAAEDPQSPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEI 1191

Query: 500  LATESSNQEYVRMLLDLQT---KSALKETEIKEITVSFLQKITDLQN-----QLKQQEED 551
            L  +   +E   + L+ Q    K+ L + ++ +I     QK    QN     QLK ++E+
Sbjct: 1192 LRMKEQLREMENLRLESQQLIEKNWLLQGQLDDIK---RQKENSDQNHPDNQQLKNEQEE 1248

Query: 552  FRKQ-----------------LEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPF 594
              K+                 LE+ +     KE     +T+E+ + + L  + + + +  
Sbjct: 1249 SIKERLAKSKIVEEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQL 1308

Query: 595  QLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKS 654
            + +L+    E++    E    ++Q+  + +   KL+GHQNL QKI++VV+LK EN +L  
Sbjct: 1309 RSKLEEMYEERERTSQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLAE 1368

Query: 655  EVSKLRCQ---LAKKKQSET 671
            E  KLR +   L +KK+SE+
Sbjct: 1369 ETEKLRAENVFLKEKKRSES 1388



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 162/747 (21%), Positives = 321/747 (42%), Gaps = 121/747 (16%)

Query: 38   FQKSQRFKQQKESKQNLNVDKDTTLP-ASARKVKSSESKKESQKNDKD----LKILEKEI 92
            FQ++  F ++ E ++   ++K T L   + +K K  +S K   K  +D    L+ L KE 
Sbjct: 418  FQEAMLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEKLHKES 477

Query: 93   RV-LLQERGAQDRRIQDLETELEKMEARL------------NAALREKT----------- 128
            R   L E   QDR + +L  E++ +  ++            N +LRE+            
Sbjct: 478  RGGFLPEE--QDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKR 535

Query: 129  --SLSANN-ATLEKQLIELTRTNELLKSK--FSENGNQKNLRILSLELMKLRNKR-ETKM 182
               + A   A LEK   E++   +  K++  FS    ++     + E +K +  + +T++
Sbjct: 536  AQEMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTEL 595

Query: 183  RGMMAKQEGMEMKLQVTQRSLE-ESQGKIAQ-----LEGKLVSIEKEKIDEKSETEKLLE 236
                +KQE  E K    +R LE ES+ +  Q     LE  L + +  K  E S+  K+  
Sbjct: 596  NN--SKQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEVSQLNKI-- 651

Query: 237  YIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQL 296
            + E +   +   + Y+L        + + + E+ S      +N  IL   + +  V  ++
Sbjct: 652  HAETLKIITTPTKAYQLH----SRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEM 707

Query: 297  LEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSS 356
             E+  E      R   E ++A    L+ K   E+ +  KLQQ   +++    Q +EL SS
Sbjct: 708  NEQAFEAISEELRTVQEQMSA----LQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSS 763

Query: 357  LHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKL 416
                    QEE++ + N+ E++L++T  + D L+ +      ++   ++E  S    +KL
Sbjct: 764  ERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSS----VKL 819

Query: 417  LEEKLK-GKEAELEKSSAAHTQATL-----------------LLQEKYDSMVQSLEDVTA 458
                 K  +E E  K S  H    L                  LQ+ YD++ + ++    
Sbjct: 820  EYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEID 879

Query: 459  QFESYKALTASEIEDLKLENSSLQE--KAAKAGKNAEDVQHQILATESSNQEYVRML--- 513
            Q          E E LK + ++L E  +A K   N   +Q +    E+S++E +++L   
Sbjct: 880  QLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFE-EDKENSSKEILKVLEAV 938

Query: 514  -LDLQTKSALKETEIKEI------------TVSFLQK--------ITDLQNQLKQQEEDF 552
              + Q ++A  E ++ ++             +S L+K        + DL NQ+++     
Sbjct: 939  RQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRTSV 998

Query: 553  RKQLEDEEGRKAEKENTTAELTEEI---NKWRLLYE----ELYNKTKPFQLQLDAFEVEK 605
             ++ E  +  K E ++   +    +    + R+L +    ++ +  +  +L++ + ++E+
Sbjct: 999  CEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKETLRLRILSEDIER 1058

Query: 606  QALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAK 665
              L  +   A EQLN + ++  K   H  L Q        ++E ++ ++ + +L+ +L +
Sbjct: 1059 DMLCEDLAHATEQLNMLTEASKK---HSGLLQ------SAQEELTKKEALIQELQHKLNQ 1109

Query: 666  KKQSETKLQEELN-KVLGIKHFDPSKA 691
            KK+   + + E N K+  ++H   S A
Sbjct: 1110 KKEEVEQKKNEYNFKMRQLEHVMDSAA 1136


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score =  127 bits (319), Expect = 4e-29
 Identities = 143/684 (20%), Positives = 308/684 (45%), Gaps = 87/684 (12%)

Query: 68  KVKSSESKKESQKNDKDLKILEKEIR--VLLQERGA----QDRRIQDLETELEKMEARLN 121
           +++ +E++K   + D  + ++++ I    LL E+ A    + + +++L  + E +  RL+
Sbjct: 234 ELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLH 293

Query: 122 AALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETK 181
             L++   L    + +++++ +L+  N  L  K  E  +  +L+ L   L +L  +    
Sbjct: 294 ETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFAS--HLQQLQDALNELTEEHSKA 351

Query: 182 MRGMMAKQEGMEMKLQVT---QRSLEES----QGKIAQLEGKLVSIEKEKIDEKSETE-- 232
            +  + KQ  +E +L      ++ LEE     QGK++QLE  L  ++     EK E    
Sbjct: 352 TQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGD 411

Query: 233 --KLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDL 290
             +L    +E +  +    + +  +  LE    ++  ++L+ +   EE    LS  + DL
Sbjct: 412 VLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDL 471

Query: 291 NVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFI---------------LEQQEREK 335
                 L + KE+    ++ H   L A++ +L  +                 L+QQ +EK
Sbjct: 472 QSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEK 531

Query: 336 -------LQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDK 388
                  LQQ+E     L  Q ++LSSSL QK    +E   K++   ++  +Q     ++
Sbjct: 532 QAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEE 591

Query: 389 LQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQA---TLLLQEK 445
            +    + +  +KQLE   K +A +L++L+++L+      + +  + TQA      L  K
Sbjct: 592 REASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRK 651

Query: 446 YDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAED---VQHQILA- 501
            + +   +E  TA+ E ++A   +++ +L+L+  S Q+KA +  + A++   +Q Q+ A 
Sbjct: 652 VEELQACVE--TARQEQHEA--QAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQAL 707

Query: 502 ------TESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQE------ 549
                 T+ S +E  R   D   +     +E+K  T S +++    + +L+++       
Sbjct: 708 KESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGL 767

Query: 550 ---------------EDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPF 594
                          E  R++L +    +   E+   +L +E+  WR  YE+   +   +
Sbjct: 768 EARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQY 827

Query: 595 QLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKS 654
                 F+ +   L  E   A+++L + ++  A +  H  L+     + + ++E ++L +
Sbjct: 828 GAM---FQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQ-----ISRQQNELAELHA 879

Query: 655 EVSKLRCQLAKKKQSETKLQEELN 678
            +++   Q+ +K+    KL ++L+
Sbjct: 880 NLARALQQVQEKEVRAQKLADDLS 903



 Score = 99.8 bits (247), Expect = 8e-21
 Identities = 154/679 (22%), Positives = 281/679 (41%), Gaps = 95/679 (13%)

Query: 97   QERGAQDRRIQDLETELEKMEA--RLNAALREKTSLSANNATLEKQLIELTRTNELLKSK 154
            +ERG Q+R +  L  E  + +A   L  A R +  +   NA L +Q +E     E L   
Sbjct: 997  EERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNA-LNEQRVEFATLQEALAHA 1055

Query: 155  FSENGNQKNLRILSLELMKLRNKRETKMRGMMA-KQEGMEMKLQVTQRSLEESQGKIAQL 213
             +E   +        EL KLR     +++ +   +Q   ++K Q+ ++  E + G  AQ 
Sbjct: 1056 LTEKEGKDQ------ELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQS 1109

Query: 214  EG---------KLVSIEKEKIDEKSETEKLLEYIEEI--SCASDQVEKYKLDIA--QLEE 260
            E          KL ++  E    + + +K  E  + +  S  +++  + + D A   L+ 
Sbjct: 1110 EAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQG 1169

Query: 261  NLKEKNDEI---LSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNA 317
             L+EK  E+    S   S +  +     +V+D +      E E +  V R R+  E  N+
Sbjct: 1170 QLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKA----EDEWKAQVARGRQEAERKNS 1225

Query: 318  EMQNLKQKF-ILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFE 376
             + +L+++  IL +Q  EK + +  ++  L+  E E S  L ++L   Q E         
Sbjct: 1226 LISSLEEEVSILNRQVLEK-EGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAA 1284

Query: 377  EELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAE-------ELKLLEEKLKGKEAELE 429
            E      +E+  L+++ E+     + L +E  S+AE       ELK  +EK   KE  L 
Sbjct: 1285 ERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALS 1344

Query: 430  KSSAAHTQATLLLQEKYDS--MVQSLEDVTAQFE---------SYKALTASEIEDLKLEN 478
                 HT    L+ E   +  + Q L+   A  E         S +A      E L+ + 
Sbjct: 1345 TLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQR 1404

Query: 479  S-----SLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSA------------ 521
                   L++K A+  + A+    Q+ A ++S  E + ML       A            
Sbjct: 1405 ELGELIPLRQKVAEQERTAQ----QLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANL 1460

Query: 522  ---LKETEIKEITVSFLQKI----TDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELT 574
                 E E+ +    ++Q++     D + +L + + + +    + E   A+ E    ++ 
Sbjct: 1461 GRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVL 1520

Query: 575  EEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDS-YAKLLGHQ 633
            EE    R  ++E   K      QL+ F+ E+          +E   K+ DS  A  +  Q
Sbjct: 1521 EE----RQRFQEERQKLTAQVEQLEVFQREQTK------QVEELSKKLADSDQASKVQQQ 1570

Query: 634  NLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQS--ETKLQEELNKVLGIKHFDPSKA 691
             LK       + + E  +L++++++L+ QL++K+Q+    KLQ E  K     H+D  K 
Sbjct: 1571 KLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKT----HYDAKKQ 1626

Query: 692  FHHESKENFALKTPLKEGN 710
             + E +E       L++ N
Sbjct: 1627 QNQELQEQLRSLEQLQKEN 1645



 Score = 97.1 bits (240), Expect = 5e-20
 Identities = 126/658 (19%), Positives = 274/658 (41%), Gaps = 62/658 (9%)

Query: 23   AYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT---TLPAS----ARKVKSSESK 75
            A  +K LE L+  V   K Q  K++KE         +    T P      A + + S+ +
Sbjct: 1074 AAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLE 1133

Query: 76   KESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNA 135
            ++ QK  +    LE+ +      R  +D  ++ L+ +LE+    L  +     S     A
Sbjct: 1134 QQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELA 1193

Query: 136  TLEKQLIELTRTNELLKSKFS---ENGNQKNLRILSLE----------LMKLRNKRETKM 182
                ++ + ++  +  K++ +   +   +KN  I SLE          L K    +E K 
Sbjct: 1194 AFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELK- 1252

Query: 183  RGMMA---KQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLL--EY 237
            R +MA   K + +E +L++ Q     +  + A+    L   E + + E++E +++     
Sbjct: 1253 RLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALRE-EVQSLREEAEKQRVASENL 1311

Query: 238  IEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLL 297
             +E++  +++ E+   ++   +E   +K   + +L+        ++S+ +   ++ CQ L
Sbjct: 1312 RQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHL-CQQL 1370

Query: 298  EKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQE-------REKLQQKELQIDSLLQQE 350
            + E+     R+RE  E        L+ + +  Q+E       R+K+ ++E     L  ++
Sbjct: 1371 QAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEK 1430

Query: 351  KELSSSL------HQKLCSFQEEMVKEKNLFEEELKQTLDE-----LDKLQQKEEQAERL 399
               +  L      H  L      + +  NL  + L+  LD+     + +L      AE  
Sbjct: 1431 ASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETR 1490

Query: 400  VKQLEEEAKSRAEELKLLEEKLKGKEA----------ELEKSSAAHTQATLLLQEKYDSM 449
            + +++ EA+S A EL+++  K +G +           E  +   A  +   + Q +    
Sbjct: 1491 LAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQ 1550

Query: 450  VQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEY 509
            V+ L    A  +    +   +++ ++ +    Q++A +      ++Q Q+   E + + Y
Sbjct: 1551 VEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHY 1610

Query: 510  VRMLLDLQTKSALKETEIKEI--TVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKE 567
               +   +T    K+ + +E+   +  L+++     +L+ + E    +L+    +  E E
Sbjct: 1611 KLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAE 1670

Query: 568  NTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDS 625
             T   LT ++   R L  ++ +  +  +  L  F+V   AL +    A+ QL+   DS
Sbjct: 1671 QTCRHLTAQV---RSLEAQVAHADQQLR-DLGKFQVATDALKSREPQAKPQLDLSIDS 1724



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 151/728 (20%), Positives = 302/728 (41%), Gaps = 114/728 (15%)

Query: 39   QKSQRFKQQKESKQNLNVDKD---TTLPASARKVKSSESKKESQKND--KDLKILEKEIR 93
            Q +Q  +QQ+++ Q L    +   ++L    +++K    K+E+ + D  + L    +E  
Sbjct: 534  QLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEERE 593

Query: 94   VLLQERGAQDRRIQDLETE----LEKMEARLNAALREKTSLSANNATLEKQLIELTRTNE 149
              L+ER A  ++++ LE E    LE ++ +L  A   + S   +    +++  EL+R  E
Sbjct: 594  ASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVE 653

Query: 150  LLKSKFS---ENGNQKNLRILSLEL-MKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEE 205
             L++      +  ++   ++  LEL ++   ++ T+   +  +++ ++ +LQ  + SL+ 
Sbjct: 654  ELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKV 713

Query: 206  SQGKIAQLEGKLVSIEKEK---IDE-KSETEKLLEYIEEISCASDQVEKYKLDIAQLEEN 261
            ++G + + + +     +E+   I E K+ET  L   +E+      ++E+ +     LE  
Sbjct: 714  TKGSLEEEKRRAADALEEQQRCISELKAETRSL---VEQHKRERKELEEERAGRKGLEAR 770

Query: 262  LKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK-------EDHVNRNREHNEN 314
            L++  +   +  + L   +            +C+ L KE        ED      ++   
Sbjct: 771  LQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAM 830

Query: 315  LNAEMQNLKQKFILEQQEREKLQQK--------ELQIDSLLQQEKELSSSLHQKLCSFQE 366
               ++  LK++    +QE ++ ++K        ELQI     +  EL ++L + L   QE
Sbjct: 831  FQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQE 890

Query: 367  EMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEA 426
            + V+ + L         D+L  LQ+K     + V +LE   +   E+ +    +L  + A
Sbjct: 891  KEVRAQKL--------ADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPA 942

Query: 427  -----------ELEKSSAAHTQATL-LLQEKYDSMVQSLEDVTA-------QFESYKALT 467
                       E +      TQA L  ++ + + M   LE + A       Q +  +   
Sbjct: 943  RAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQ 1002

Query: 468  ASEIEDLKLENSSLQ-----EKAAKAG-----KNA------------EDVQHQILATESS 505
              E+  L  E    Q     EKAA+A      +NA            E + H +   E  
Sbjct: 1003 EREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGK 1062

Query: 506  NQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAE 565
            +QE  ++         L+  +IKE     L+++     QLK+Q     K+     G ++E
Sbjct: 1063 DQELAKL-------RGLEAAQIKE-----LEELRQTVKQLKEQLAKKEKEHASGSGAQSE 1110

Query: 566  KENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFE---VEKQALLNEHGAAQEQLNKI 622
                T     ++   R    +L  + +  Q Q D+ E     ++A   E  +A E L   
Sbjct: 1111 AAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQ 1170

Query: 623  RDSYAKLLGHQN------------LKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSE 670
             +  A+ LGH               + K++   K +DE    K++V++ R +  +K    
Sbjct: 1171 LEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDE---WKAQVARGRQEAERKNSLI 1227

Query: 671  TKLQEELN 678
            + L+EE++
Sbjct: 1228 SSLEEEVS 1235



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 146/676 (21%), Positives = 273/676 (40%), Gaps = 103/676 (15%)

Query: 46  QQKESKQNLNVDKDTTLPASARKVKSSESKKESQ--------KNDKDLKI----LEKEIR 93
           QQ+  +  L  +K    P   ++++    K ES         K  +DLK     ++++I 
Sbjct: 255 QQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKIN 314

Query: 94  VLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSAN----NATLEKQLIE------ 143
            L +E G    ++++  + L++++  LN    E +  +       A LEK+L        
Sbjct: 315 QLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKK 374

Query: 144 -LTRTNELLKSKFSE----------NGNQKNLRILS--LELMKLRNKRETKMRGMMAKQE 190
            L   NE+L+ K S+          N  Q+   +L   L+L  L+ +  T        Q 
Sbjct: 375 CLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQA 434

Query: 191 GMEM----------KLQVTQRSLEESQGKIAQLEGKL------VSIEKEKIDEKSE---- 230
            +EM          KL   +   EE + +++ L   L      +S  KE++++ S+    
Sbjct: 435 RVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGA 494

Query: 231 --TEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVE 288
             T ++     E++  +  +++   ++A L++  KEK  ++    Q  E+    L  QVE
Sbjct: 495 RLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVE 554

Query: 289 DLNVKCQLLEKE-----------KEDHVNRNREHNENLNAEMQN----LKQKFILEQQER 333
            L+   +  E++           ++DH  +     E   A ++     LKQ   LE+++ 
Sbjct: 555 QLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKA 614

Query: 334 EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKE 393
            KL+  + Q    LQ   E   S    +   Q E  +     EE   Q   E  + +Q E
Sbjct: 615 AKLEILQQQ----LQVANEARDSAQTSVTQAQREKAELSRKVEE--LQACVETARQEQHE 668

Query: 394 EQAE--RLVKQLEEEAKSRAEELKLLEEKLKGKEA-ELEKSSAAHTQATLLLQEKYDSMV 450
            QA+   L  QL  E +   E+ ++ +EK + +E  +  K S   T+ +L  +E+     
Sbjct: 669 AQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSL--EEEKRRAA 726

Query: 451 QSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILA------TES 504
            +LE+        KA T S +E  K E   L+E+  +AG+   + + Q L       TE 
Sbjct: 727 DALEEQQRCISELKAETRSLVEQHKRERKELEEE--RAGRKGLEARLQQLGEAHQAETEV 784

Query: 505 SNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD-----------LQNQLKQQEEDFR 553
             +E    +    T  +  E  +KE+  ++ ++  D            Q QL   +E+  
Sbjct: 785 LRRELAEAMAAQHTAESECEQLVKEVA-AWRERYEDSQQEEAQYGAMFQEQLMTLKEECE 843

Query: 554 KQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHG 613
           K  ++ +  K +     +    +I++ +    EL+        Q+   EV  Q L ++  
Sbjct: 844 KARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLS 903

Query: 614 AAQEQLNKIRDSYAKL 629
             QE++       A+L
Sbjct: 904 TLQEKMAATSKEVARL 919


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  125 bits (315), Expect = 1e-28
 Identities = 160/693 (23%), Positives = 302/693 (43%), Gaps = 65/693 (9%)

Query: 47   QKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKE--IRVLLQERGAQDR 104
            Q++ K  L   +   L  S  K +      E  +  K   + E E  +R L QE      
Sbjct: 508  QEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRT 567

Query: 105  RIQDLETELEK-MEARLNAALREKTSLSANNATLEKQL---IELTRTN-ELLKSKFSENG 159
            RI +LE+ LEK ++   N +      L A      K++   +E  +T  E LK +     
Sbjct: 568  RILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALW 627

Query: 160  NQKNLRILS----LELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGK-IAQLE 214
             +K L++L      E+ KLR K E +   ++  +E       + Q  +EE   K + +L+
Sbjct: 628  TEK-LQVLKQQYQTEMEKLREKCEQEKETLLKDKE------IIFQAHIEEMNEKTLEKLD 680

Query: 215  GKLVSIEK--EKIDEKSETEKLLEYIEEISCASDQVEKYKLDI-AQLEENLKEKNDEILS 271
             K   +E    ++ E  +    LE  EE+S   DQ +K K ++ A+++E       ++ S
Sbjct: 681  VKQTELESLSSELSEVLKARHKLE--EELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDS 738

Query: 272  LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ 331
            + +  E +I    K ++D   + +LL KE++ H+  ++ H ENL A+++  + +      
Sbjct: 739  IIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASA 798

Query: 332  EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQ 391
            + +  Q  +       +  +E  + L QKL   + E +       E   Q  D   +L  
Sbjct: 799  KLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDA 858

Query: 392  KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 451
             + Q + L++QLE++     +++K L +     E++LE  +    Q   +L EK + ++Q
Sbjct: 859  HKIQVQDLMQQLEKQNSEMEQKVKSLTQVY---ESKLEDGNKEQEQTKQILVEKENMILQ 915

Query: 452  SLE-----------DVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQIL 500
              E            ++A+ +S   L        K +   +++   KA +  E ++ ++L
Sbjct: 916  MREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLL 975

Query: 501  ATESS-NQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEED-------- 551
              E+   +E     L+L  K      ++ E+  +    I+D  ++L+  +++        
Sbjct: 976  DQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEV 1035

Query: 552  FRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQAL--- 608
             R++L D      +K N  AE  +EI++ +L  +E   +    + ++  F  EK+ +   
Sbjct: 1036 HRRELNDVISIWEKKLNQQAEELQEIHEIQL--QEKEQEVAELKQKILLFGCEKEEMNKE 1093

Query: 609  ---LNEHGAAQE-QLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLA 664
               L E G  Q+  LN+++         + LKQK  HV  L  + ++LK+ + KL   L 
Sbjct: 1094 ITWLKEEGVKQDTTLNELQ---------EQLKQKSAHVNSLAQDETKLKAHLEKLEVDLN 1144

Query: 665  KKKQSETKLQEELNKVLGIKHFDPSKAFHHESK 697
            K  +  T LQE+L ++  +   D  K     SK
Sbjct: 1145 KSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177



 Score =  110 bits (274), Expect = 6e-24
 Identities = 158/687 (22%), Positives = 300/687 (43%), Gaps = 109/687 (15%)

Query: 88   LEKEIRVLLQERGAQD-------RRIQDLETELEKMEARLNAALREKTSLSANNATLEKQ 140
            LE ++R L +E+   +        ++++ E +++ M+A + + + EK +L       ++ 
Sbjct: 1274 LEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQA 1333

Query: 141  LIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQ 200
              E       LK + SEN N       ++ LMK   K +        K E   +  Q+T 
Sbjct: 1334 ASEKESCITQLKKELSENIN-------AVTLMKEELKEK--------KVEISSLSKQLTD 1378

Query: 201  RSLE-ESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLE 259
             +++ ++   +++ E  + S+ K+  +EK E   LL+ ++++S   D + K K+   +  
Sbjct: 1379 LNVQLQNSISLSEKEAAISSLRKQYDEEKCE---LLDQVQDLSFKVDTLSKEKISALEQV 1435

Query: 260  ENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE---KEDHVNRNREHNENLN 316
            ++   K  E    K+  +         V++L ++ +L  KE   K++ +N  +E  +  N
Sbjct: 1436 DDWSNKFSE---WKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQN 1492

Query: 317  AEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEK----ELSSSLHQKLCSFQE--EMVK 370
                 LK +    + ++ K+++KE  +++ L+ +     EL   + QK    +   E++K
Sbjct: 1493 KRFDCLKGEM---EDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLK 1549

Query: 371  ----EKNLFEEELKQTLDELDKLQQKEE----QAERLVKQLEEEAKSRAEEL-------- 414
                +K++  +EL Q L    +L ++++    +AE  +  LE +  S   EL        
Sbjct: 1550 NYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELE 1609

Query: 415  ------KLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMV--QSLEDVTAQFESYKAL 466
                  K  EE+LK  E  LE  SAA         E+  + +  Q L  +  + E YK  
Sbjct: 1610 HVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKG 1669

Query: 467  TASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETE 526
            T S + +L   N+ LQE+     +    ++ ++ + ESS  E   +++    K+    TE
Sbjct: 1670 TESHLSEL---NTKLQERE----REVHILEEKLKSVESSQSE--TLIVPRSAKNVAAYTE 1720

Query: 527  IKE------ITVSFLQKITDLQNQLKQQEEDFRKQLEDEE--------------GRKAEK 566
             +E      +  ++ +KI+ LQ  L ++E+  ++  +++E               R  + 
Sbjct: 1721 QEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKL 1780

Query: 567  ENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSY 626
            E+  A+  E+ +    L EEL  K K + L + A  VEK+   N   A Q   N   D  
Sbjct: 1781 EHAEAKQHEDQSMIGHLQEELEEKNKKYSL-IVAQHVEKEGGKNNIQAKQNLENVFDDVQ 1839

Query: 627  AKL----LGHQNLKQKIKH----VVKLKD----ENSQLKSEVSKLRC-QLAKKKQSETKL 673
              L    L  Q L+QKIK     +V+ K+    E  +L S+  KL+  Q    +   T+L
Sbjct: 1840 KTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTEL 1899

Query: 674  QEELNKVLGIKHF-DPSKAFHHESKEN 699
             EE  +     H   P    + E++ N
Sbjct: 1900 LEENTEEKSKSHLVQPKLLSNMEAQHN 1926



 Score =  105 bits (261), Expect = 2e-22
 Identities = 162/722 (22%), Positives = 298/722 (41%), Gaps = 102/722 (14%)

Query: 47   QKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRI 106
            Q+  KQN  +++         + K  +  KE ++  + L  +EKE  ++LQ R  Q + I
Sbjct: 868  QQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQIL--VEKE-NMILQMREGQKKEI 924

Query: 107  QDLETELEKMEARLNAALRE-KTSLSANNATLEKQLIELTRTNELLKSKF--SENGNQKN 163
            + L  +L   E  ++    E +T        +EK   +     E LK K    E   +K 
Sbjct: 925  EILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKE 984

Query: 164  LRILSLELMKLRNKRETKMRGM-MAKQEGME---MKLQVTQRSLEESQGKIAQLE-GKLV 218
            L   +LEL +   +   KM  M  A   G+     +L+  Q+   ES  ++ + E   ++
Sbjct: 985  LENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVI 1044

Query: 219  SIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENL-------KEKNDEILS 271
            SI ++K+++++E    L+ I EI     Q+++ + ++A+L++ +       +E N EI  
Sbjct: 1045 SIWEKKLNQQAEE---LQEIHEI-----QLQEKEQEVAELKQKILLFGCEKEEMNKEITW 1096

Query: 272  LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ 331
            LK+   +    L++  E L        K+K  HVN   +    L A ++ L+       +
Sbjct: 1097 LKEEGVKQDTTLNELQEQL--------KQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLK 1148

Query: 332  EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDE-LDKLQ 390
            E   LQ++ +++  L +++K   S L  KL +  EE    K+  E+  K   D+ L+  +
Sbjct: 1149 ENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKK 1208

Query: 391  QKEEQAERL---VKQLEEEAKSRAEELKLLEEK----------------LKGKEA----- 426
              EE A +L    K+ E   +++  EL  +                    K KEA     
Sbjct: 1209 LSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKT 1268

Query: 427  ----ELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQ 482
                ELE      T+    L   +      LE+   Q +S KA    +IE L  E  +LQ
Sbjct: 1269 CTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKA----DIESLVTEKEALQ 1324

Query: 483  EKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQ 542
            ++     + A + +  I   +    E +  +  ++ +   K+ EI  ++         LQ
Sbjct: 1325 KEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQ 1384

Query: 543  NQLKQQEED-----FRKQLEDEEGRKAE-------------KENTTAELTEEINKWRLLY 584
            N +   E++      RKQ ++E+    +             KE  +A   E+++ W   +
Sbjct: 1385 NSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISA--LEQVDDWSNKF 1442

Query: 585  EEL-----------YNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQ 633
             E             N  K  Q+QL+    E      +    +E+L++    +  L G  
Sbjct: 1443 SEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEM 1502

Query: 634  NLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKAFH 693
                K K   K  +  ++LKS+ +++  +L      +T   E LN+VL  K+++  K   
Sbjct: 1503 E-DDKSKMEKKESNLETELKSQTARI-MELEDHITQKTIEIESLNEVL--KNYNQQKDIE 1558

Query: 694  HE 695
            H+
Sbjct: 1559 HK 1560



 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 147/649 (22%), Positives = 287/649 (44%), Gaps = 84/649 (12%)

Query: 39   QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQE 98
            QK Q F       Q L  +KD  +  +  K+ + E++  S K + + K  +KE+  +   
Sbjct: 1564 QKLQHF-------QELGEEKDNRVKEAEEKILTLENQVYSMKAELETK--KKELEHVNLS 1614

Query: 99   RGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSEN 158
              +++  ++ LE  LE   A   A L+ K       A ++KQL  L++  E  K +  + 
Sbjct: 1615 VKSKEEELKALEDRLESESAAKLAELKRKAEQKI--AAIKKQL--LSQMEE--KEEQYKK 1668

Query: 159  GNQKNLRILSLELMKLRNK---RETKMRGMMAKQ-------EGMEMKLQVTQRSLEESQG 208
            G + +L  L+ +L +   +    E K++ + + Q          +     T++   +SQG
Sbjct: 1669 GTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQG 1728

Query: 209  KIAQLEGKLVSIEKEKIDEKSETEKLLEYI-----EEISCASDQVEKYKLDIAQLEENLK 263
             + +   + +S+ +  + EK   EKLL+ +     E +S   +   +Y+  + +LE    
Sbjct: 1729 CVQKTYEEKISVLQRNLTEK---EKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEA 1785

Query: 264  EKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLK 323
            +++++        +  I  L +++E+ N K  L+  +   HV +    N N+ A+ QNL+
Sbjct: 1786 KQHED--------QSMIGHLQEELEEKNKKYSLIVAQ---HVEKEGGKN-NIQAK-QNLE 1832

Query: 324  QKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL 383
              F      ++ LQ+KEL    L Q+ KEL S L ++    + EM        EEL    
Sbjct: 1833 NVF---DDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEM--------EELTSKY 1881

Query: 384  DELDKLQQ---KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATL 440
            ++L  LQQ   + +  E L +  EE++KS   + KLL   ++ +  +LE   A   +   
Sbjct: 1882 EKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLL-SNMEAQHNDLEFKLAGAEREKQ 1940

Query: 441  LLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQIL 500
             L ++   + + L  +  + +        E+E LK E    QE+  K  +  ED++ +  
Sbjct: 1941 KLGKEIVRLQKDLRMLRKEHQ-------QELEILKKEYD--QEREEKIKQEQEDLELK-- 1989

Query: 501  ATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEE 560
                 N    +++ +  T+ A KE E++      + K  +++ +L +  ++   QL  + 
Sbjct: 1990 ----HNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKI 2045

Query: 561  GRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLN 620
              K +    TA+  EEI   R   EE+  K +  Q QL+  + + Q  L      +++ N
Sbjct: 2046 AEKDDDLKRTAKRYEEILDAR--EEEMTAKVRDLQTQLEELQKKYQQKL------EQEEN 2097

Query: 621  KIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQS 669
               D+   +     L QK   +   K +  + + ++  L  +L K +++
Sbjct: 2098 PGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKN 2146



 Score = 93.6 bits (231), Expect = 6e-19
 Identities = 163/707 (23%), Positives = 310/707 (43%), Gaps = 123/707 (17%)

Query: 26   VKTLEV---LKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKND 82
            VK L++   LK   +++K ++    KE     N   D  L       KS   KKES    
Sbjct: 1460 VKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDC-LKGEMEDDKSKMEKKESN--- 1515

Query: 83   KDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLI 142
                 LE E++       +Q  RI +LE  + +    + +      + +       K+L+
Sbjct: 1516 -----LETELK-------SQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELV 1563

Query: 143  ELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRS 202
            +  +        F E G +K+ R+   E   L    E ++  M A+ E  + +L+    S
Sbjct: 1564 QKLQ-------HFQELGEEKDNRVKEAEEKIL--TLENQVYSMKAELETKKKELEHVNLS 1614

Query: 203  LEESQGKIAQLEGKLVSIEKEKIDE-KSETEKLLEYIEE--ISCASDQVEKYK----LDI 255
            ++  + ++  LE +L S    K+ E K + E+ +  I++  +S   ++ E+YK      +
Sbjct: 1615 VKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHL 1674

Query: 256  AQLEENLKEKNDEILSLKQSLEENIVILSKQVEDL-------NVKCQLLEKEKEDHVNRN 308
            ++L   L+E+  E+  L++ L+    + S Q E L       NV     ++E +      
Sbjct: 1675 SELNTKLQEREREVHILEEKLKS---VESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQ 1731

Query: 309  REHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKL-CSFQEE 367
            + + E ++   +NL         E+EKL Q+       + QEKE + S H ++ C +QE 
Sbjct: 1732 KTYEEKISVLQRNL--------TEKEKLLQR-------VGQEKEETVSSHFEMRCQYQER 1776

Query: 368  MVKEKNLFEEELKQTLDE------LDKLQQKEEQAERLVKQLEE--------EAKSRAEE 413
            ++K   L   E KQ  D+       ++L++K ++   +V Q  E        +AK   E 
Sbjct: 1777 LIK---LEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLEN 1833

Query: 414  L-----KLLEEK------LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFES 462
            +     K L+EK      L+ K  EL+         + L+++K    V+ +E++T+++E 
Sbjct: 1834 VFDDVQKTLQEKELTCQILEQKIKELD---------SCLVRQKEVHRVE-MEELTSKYEK 1883

Query: 463  YKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSAL 522
             +AL   +++        L+E   +  K+     H +     SN E     L+ +   A 
Sbjct: 1884 LQAL--QQMDGRNKPTELLEENTEEKSKS-----HLVQPKLLSNMEAQHNDLEFKLAGAE 1936

Query: 523  KETEIKEITVSFLQK-ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWR 581
            +E +     +  LQK +  L+ + +Q+ E  +K+ + E   K ++E    EL       +
Sbjct: 1937 REKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQ 1996

Query: 582  LLYE---ELYNKTKPFQLQL-----DAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQ 633
            L+ E   +L  K +  ++ +      A EVE + LL  H   QE+ N++    A+     
Sbjct: 1997 LMREFNTQLAQKEQELEMTIKETINKAQEVEAE-LLESH---QEETNQLLKKIAE--KDD 2050

Query: 634  NLKQKIKHVVKLKD-ENSQLKSEVSKLRCQLAK-KKQSETKLQEELN 678
            +LK+  K   ++ D    ++ ++V  L+ QL + +K+ + KL++E N
Sbjct: 2051 DLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEEN 2097



 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 147/695 (21%), Positives = 302/695 (43%), Gaps = 103/695 (14%)

Query: 68  KVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREK 127
           +V S ES   S   +   +   KE  V    R + +R   D  T      + +++   E 
Sbjct: 68  RVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDS---EA 124

Query: 128 TSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNL----RILSLELMKLRN----KRE 179
             L  N+ +L K+ + + R   + +S  S  G    L    ++L  E  KL+      ++
Sbjct: 125 EDLVGNSDSLNKEQL-IQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQD 183

Query: 180 TKMRGMMAKQEGMEMKLQVTQR-------SLEESQGKIAQLEGKLVSIEKEKIDEKSETE 232
             +R +   +E ++M  Q  +        SLEE    I+ L+ + VS+ K+++       
Sbjct: 184 KSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQ-VSLLKQRLRNGPMNV 242

Query: 233 KLLEYIEEISCASDQVEKYKLDIAQ----LEENLKEKNDEILSLKQSLEENIVILSKQ-V 287
            +L+ + ++   ++   K +   +     +E+    K  E L  +   +EN++   K+ +
Sbjct: 243 DVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETI 302

Query: 288 EDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLL 347
           +    +C LL  EKE          E L+  +Q L++   L   E+ KL  +     +L+
Sbjct: 303 QSHKEQCTLLTSEKE-------ALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLI 355

Query: 348 QQEK--------ELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL 399
           +Q +        E    +H+ L   +EE+ + ++     +KQ   + ++L++++E++ER 
Sbjct: 356 EQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRS----RIKQMTTQGEELREQKEKSERA 411

Query: 400 VKQLEEEAKSRAEELKLLEEKLKGKEAE----LEKSSAAHTQATLLLQEKYDSMVQSLED 455
             +  E+A S A++ +    KLK +  E    +EK+S    +  + LQ++   + Q + D
Sbjct: 412 AFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSE---EERISLQQELSRVKQEVVD 468

Query: 456 VTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI-LATESSNQEYVRML- 513
           V  +    +     ++ + +L     QE   K      + Q Q+ +A E S  EY+++  
Sbjct: 469 VMKKSSEEQIAKLQKLHEKELARKE-QELTKKLQTREREFQEQMKVALEKSQSEYLKISQ 527

Query: 514 ------------LDLQTKSALKETE-----IKEITVSFLQKITDLQNQLKQQEEDFRKQL 556
                       L+LQ K+ L E+E     +++   ++  +I +L++ L++  ++ + Q 
Sbjct: 528 EKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQS 587

Query: 557 ED-EEGRKAEKENTTAELTEEINKWRLLYEELYNK-----TKPFQLQLDAFEVEKQALLN 610
           +D     +AEK     E+T  + K +   E L ++     T+  Q+    ++ E + L  
Sbjct: 588 KDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLRE 647

Query: 611 EHGAAQEQLNK---------IRDSYAKLLGHQNLKQ--------------KIKHVVKLKD 647
           +    +E L K         I +   K L   ++KQ              K +H  KL++
Sbjct: 648 KCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARH--KLEE 705

Query: 648 ENSQLKSEVSKLRCQL-AKKKQSETKLQEELNKVL 681
           E S LK +  K++ +L AK  + +   Q++++ ++
Sbjct: 706 ELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSII 740



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 125/603 (20%), Positives = 248/603 (41%), Gaps = 109/603 (18%)

Query: 29   LEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKIL 88
            +  +K  +  Q  ++ +Q K+  ++   + +T L    R+V   E K +S ++ +   ++
Sbjct: 1648 IAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLI 1707

Query: 89   ----EKEIRVLLQERGAQ---------DRRIQDLETELEKMEARLNAALREKTSLSANNA 135
                 K +    ++  A          + +I  L+  L + E  L    +EK    +++ 
Sbjct: 1708 VPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHF 1767

Query: 136  TLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMK 195
             +  Q  E  R  +L  ++  ++ +Q  +  L  EL + +NK+ + +     ++EG +  
Sbjct: 1768 EMRCQYQE--RLIKLEHAEAKQHEDQSMIGHLQEELEE-KNKKYSLIVAQHVEKEGGKNN 1824

Query: 196  LQV----------TQRSLEESQGKIAQLEGKLVSIE----KEKIDEKSETEKLLEYIEEI 241
            +Q            Q++L+E +     LE K+  ++    ++K   + E E+L    E++
Sbjct: 1825 IQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKL 1884

Query: 242  SCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK 301
              A  Q++        LEEN +EK+   L   + L      +  Q  DL  K    E+EK
Sbjct: 1885 Q-ALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSN----MEAQHNDLEFKLAGAEREK 1939

Query: 302  E-----------DHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQID------ 344
            +           D     +EH +    E++ LK+++  E++E+ K +Q++L++       
Sbjct: 1940 QKLGKEIVRLQKDLRMLRKEHQQ----ELEILKKEYDQEREEKIKQEQEDLELKHNSTLK 1995

Query: 345  --------SLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQA 396
                     L Q+E+EL  ++ + +   QE    E  L E   ++T   L K+ +K++  
Sbjct: 1996 QLMREFNTQLAQKEQELEMTIKETINKAQEV---EAELLESHQEETNQLLKKIAEKDDDL 2052

Query: 397  ERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLED- 455
            +R  K+ EE   +R EE   +  K++  + +LE+           LQ+KY   ++  E+ 
Sbjct: 2053 KRTAKRYEEILDAREEE---MTAKVRDLQTQLEE-----------LQKKYQQKLEQEENP 2098

Query: 456  -----VTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILAT-------- 502
                    + ++  A   + I D KL+    +E+        +  +  + AT        
Sbjct: 2099 GNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYATTVGTPYKG 2158

Query: 503  ------------ESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEE 550
                        E +  EY+R +L         +T  K IT   + K  D Q Q   + E
Sbjct: 2159 GNLYHTDVSLFGEPTEFEYLRKVLFEYMMGRETKTMAKVITT--VLKFPDDQTQKILERE 2216

Query: 551  DFR 553
            D R
Sbjct: 2217 DAR 2219


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score =  124 bits (311), Expect = 3e-28
 Identities = 171/764 (22%), Positives = 331/764 (43%), Gaps = 109/764 (14%)

Query: 38   FQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQ 97
            F K    +  ++S++   V+    +  S  K+   +     Q+++K L+ LEKEI+ L +
Sbjct: 762  FLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLE-LEKEIKCLQE 820

Query: 98   ERGAQDRRIQD-----------LETELEKMEARLNAA---------LREKTSLSANNATL 137
            E   Q   ++            L  ELE++++   A            EKT L   N  +
Sbjct: 821  ESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLI 880

Query: 138  EKQLIELTRT-----NELLKSKFSENGN------QKNLRILSLELMKLRN---KRETKMR 183
            + + +  T +     NE  K    E+ N      QK LR    EL+ L++   K  +   
Sbjct: 881  QVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKN 940

Query: 184  GMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISC 243
              ++  + +E K++  ++  +E + KI +++   V  +KE    + ET+ + E +E +  
Sbjct: 941  DPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRS 1000

Query: 244  ASDQVEKYKLDIAQLEENLK------EKNDEILSLKQ----SLEENIVILSKQVEDLNVK 293
              DQ+     D+ Q  E+ K      EK  E L +++    + E  I  L++Q+ +  ++
Sbjct: 1001 EKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQ 1060

Query: 294  CQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEK-E 352
            C+ +  + ED + R      N       L +  ILE Q  + +  KEL+ + L +++K +
Sbjct: 1061 CETINSDNEDLLARIETLQSN-----AKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIK 1115

Query: 353  LSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQA----------ERLVKQ 402
              ++   +L   Q ++ KEK    ++L++T+ EL+ +++  +Q           ERL+K+
Sbjct: 1116 EHATTVNELEELQVQLQKEK----KQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKE 1171

Query: 403  --------------LEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLL----QE 444
                          LE+E K + ++ + L+E++   ++ +++    +T+   LL    +E
Sbjct: 1172 LNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKE 1231

Query: 445  KYDSMVQSLEDVTAQFESYKALTAS--EIEDLKLENSSLQEKAAKAGKNAEDVQHQILAT 502
              DS     + +  Q      L AS  ++E  K++ + +  +  K  ++ +    Q   T
Sbjct: 1232 LADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRT 1291

Query: 503  ESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGR 562
             S+ Q+ V     LQ +    + E   +T  F      + N LKQQ+     Q E  EG 
Sbjct: 1292 LSAYQQRVTA---LQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAE-TEGA 1347

Query: 563  KAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNK- 621
            K E+E+             +L ++L  K +  Q  L     E Q L +EH    E+ NK 
Sbjct: 1348 KQEREHL-----------EMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKM 1396

Query: 622  IRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVL 681
            ++++ +K      L++K+     ++ EN  +KSE ++   QL  + +       +  + L
Sbjct: 1397 LQETVSK---EAELREKL---CSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHL 1450

Query: 682  GIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQESWK 725
              +H    +    +  +  A    LK   T   R+P+  Q+S K
Sbjct: 1451 QEEHRKTVETLQQQLSKMEAQLFQLKNEPTT--RSPVSSQQSLK 1492



 Score =  103 bits (257), Expect = 6e-22
 Identities = 136/667 (20%), Positives = 292/667 (43%), Gaps = 70/667 (10%)

Query: 33   KGPVSFQKSQRFKQQKESKQNLNVDKDTT-LPASARKVKSSESKKESQKND--KDLKILE 89
            K  +  +K + F ++ E+ + L   K+     A    +K S +K  S KND    +K LE
Sbjct: 891  KSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELE 950

Query: 90   KEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKT-------SLSANNATLEKQLI 142
            ++I  L +E   ++ +I  ++    K +  L+++ +E         SL +    L   + 
Sbjct: 951  EKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMR 1010

Query: 143  ELTRTNELLKSKFSENGNQKNLRILSLELMKLR-NKRETKMRGMMAKQEGMEMKLQVTQR 201
            +L +  E  K+   E   Q       L++ K R N  E ++  +  +     ++ +    
Sbjct: 1011 DLIQGAESYKNLLLEYEKQSE----QLDVEKERANNFEHRIEDLTRQLRNSTLQCETINS 1066

Query: 202  SLEESQGKIAQLEG--KLVSIE-------KEKIDEKSETEKLLEYIEEISCASDQVEKYK 252
              E+   +I  L+   KL+ ++       K  +D++ E EKL +          +++++ 
Sbjct: 1067 DNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQK--------EQKIKEHA 1118

Query: 253  LDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHN 312
              + +LEE   +   E   L+++++E + ++ K  +       L+  E  D+    +E N
Sbjct: 1119 TTVNELEELQVQLQKEKKQLQKTMQE-LELVKKDAQQTT----LMNMEIADYERLMKELN 1173

Query: 313  ENL---NAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMV 369
            + L   N ++++L+Q+  +++Q++E LQ++   + S +QQ +E ++ + Q L   ++E+ 
Sbjct: 1174 QKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELA 1233

Query: 370  KEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELE 429
              K    + L        +L+  ++Q E    QL E    + +    + E LK    + +
Sbjct: 1234 DSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHK----IHEHLKTSAEQHQ 1289

Query: 430  KSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAG 489
            ++ +A+ Q    LQE+  +       VT++FESYK    + ++  K  N S+ +   +  
Sbjct: 1290 RTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQK--NKSMSQAETEGA 1347

Query: 490  KNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIK-EITVSFLQKITDLQNQLKQQ 548
            K                +E++ ML+D Q K  L++++   +I VS LQ    LQ++    
Sbjct: 1348 K--------------QEREHLEMLID-QLKIKLQDSQNNLQINVSELQ---TLQSEHDTL 1389

Query: 549  EEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNK-TKPFQLQLDAFEVEKQA 607
             E   K L++   ++AE       +  E    +  + +  ++ T   ++  ++F  + + 
Sbjct: 1390 LERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRH 1449

Query: 608  LLNEH----GAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQL 663
            L  EH       Q+QL+K+     +L      +  +     LK+   +  +++  L    
Sbjct: 1450 LQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHT 1509

Query: 664  AKKKQSE 670
              +++ E
Sbjct: 1510 VTREEGE 1516



 Score =  100 bits (250), Expect = 4e-21
 Identities = 142/702 (20%), Positives = 316/702 (45%), Gaps = 86/702 (12%)

Query: 39   QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKND--KDLKI--------- 87
            Q  Q+ ++     + L+ DK+  L A  + +    +K  S+K    +DL++         
Sbjct: 661  QNDQKLEKLMVQMKVLSEDKEV-LSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVI 719

Query: 88   -------LEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQ 140
                   LEK+++++++E+   ++ +++ + +   ++ +L   L+E  S  + ++  +  
Sbjct: 720  LKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDV 779

Query: 141  LIELTRTNELLKSKFSENGN---QKNLRILSL--ELMKLRNKRETKMRGMMAKQEGMEMK 195
            +  L    E L     E  N   Q++ ++L L  E+  L+ +   +   + +     E +
Sbjct: 780  VNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQE 839

Query: 196  LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEIS--CASDQV--EKY 251
              + ++ LEE Q +   L+  L+ ++      + E + LL  +EE+S  C+  ++  EK 
Sbjct: 840  KVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKE 899

Query: 252  KLDIAQLE--------ENLKEKNDEILSLKQSLEENIVILS---KQVEDLNVKCQLLE-- 298
            K  I + E        + L+++  E++ LK SL ++  + +     V++L  K + LE  
Sbjct: 900  KCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKE 959

Query: 299  -KEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSL 357
             KEKE+ +N+          ++  +K K  L+   +E    KE +++SL  ++ +LS+S+
Sbjct: 960  CKEKEEKINK---------IKLVAVKAKKELDSSRKETQTVKE-ELESLRSEKDQLSASM 1009

Query: 358  HQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLL 417
               +    +     KNL  E  KQ+ ++LD  +++    E  ++ L  + ++   + + +
Sbjct: 1010 RDLI----QGAESYKNLLLEYEKQS-EQLDVEKERANNFEHRIEDLTRQLRNSTLQCETI 1064

Query: 418  EEKLKGKEAELE--KSSAAHTQATLLLQEKYDSMV-QSLEDVTAQFE---SYKALTASEI 471
                +   A +E  +S+A   +  +L  ++  +MV + LE    Q E      A T +E+
Sbjct: 1065 NSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNEL 1124

Query: 472  EDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQE---YVRMLLDLQTKSALKETEIK 528
            E+L+++    +++  K  +  E V+     T   N E   Y R++ +L  K   K  +I+
Sbjct: 1125 EELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIE 1184

Query: 529  EI----------TVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEIN 578
            ++            +  ++IT LQ+ ++Q EE   K  +     K E  ++    T+ + 
Sbjct: 1185 DLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHL- 1243

Query: 579  KWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQK 638
               +L   L  + +  Q Q++ ++++   + +E     E L    + + + L        
Sbjct: 1244 ---ILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQ---- 1296

Query: 639  IKHVVKLKDENSQLKSEVSKLRCQL-AKKKQSETKLQEELNK 679
             + V  L++E    K+E + +  +  + K +    L+++ NK
Sbjct: 1297 -QRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNK 1337



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 132/652 (20%), Positives = 282/652 (43%), Gaps = 82/652 (12%)

Query: 66  ARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALR 125
           A + K SE K   QK  ++    + E+   L+ +   +  ++ L+ E+EK+       + 
Sbjct: 140 AVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQIL 199

Query: 126 EKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGM 185
                   +AT +++   +T+   ++++  +    QKN+  L  EL++L+   + +++ +
Sbjct: 200 YLQKQL--DATTDEKKETVTQLQNIIEA--NSQHYQKNINSLQEELLQLKAIHQEEVKEL 255

Query: 186 MAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCAS 245
           M + E           S +E + +I     KL  +++  + +   +EK ++         
Sbjct: 256 MCQIEA----------SAKEHEAEI----NKLNELKENLVKQCEASEKNIQ--------- 292

Query: 246 DQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIV---ILSKQVEDLNVKCQLLEKEK- 301
              +KY+ ++  L +     N +       L+EN     +++++V+ L    + LE +  
Sbjct: 293 ---KKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHS 349

Query: 302 --EDHVNRNREHNENLNAEMQNLKQKFILEQQE-----REKLQQKELQIDSLLQQEKELS 354
             +D V         L  + Q++K +F  E+++      E L  KE Q   ++++ K   
Sbjct: 350 ILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQ-GCVIEKLKSEL 408

Query: 355 SSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEEL 414
           + L+++ C   E+  +E    +E+ ++ + EL++    + + E+L             E+
Sbjct: 409 AGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMF---------EI 459

Query: 415 KLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDL 474
           + L+E+ +  + E +++   +     +++     + +S   ++ +FES K   AS++ +L
Sbjct: 460 QGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHEL 519

Query: 475 K-------LENSSLQEKAAK-AGKNAEDVQHQILATESSN-------QEYVRMLLDLQTK 519
           +        E  +L E   +  G+N + +  Q L  E  N       +  V +L   Q  
Sbjct: 520 QQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRD 579

Query: 520 SALKETEIKEITVSFLQKITDLQNQLKQQEED---FRKQLEDEE------GRKAEKE-NT 569
           + LKE E K    S  ++  D  N+LK   E+   F K+ E EE      G+K E+    
Sbjct: 580 TMLKELEGK--INSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQY 637

Query: 570 TAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKL 629
            +EL +++N+     EE   +      +L+   V+ + L  +      ++  + +   KL
Sbjct: 638 NSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKL 697

Query: 630 LGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVL 681
              +    +   V   + E+  LK  ++    QL KK Q   + Q+ LNK+L
Sbjct: 698 SSEKKQLSRDLEVFLSQKEDVILKEHIT----QLEKKLQLMVEEQDNLNKLL 745



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 148/719 (20%), Positives = 290/719 (40%), Gaps = 134/719 (18%)

Query: 78  SQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELE----KMEARLNAALREKTSLSAN 133
           SQ   K++  L++E   LLQ +      +++L  ++E    + EA +N     K +L   
Sbjct: 227 SQHYQKNINSLQEE---LLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQ 283

Query: 134 NATLEKQLIELTRTNELLKSKFSENGNQKN--LRILSLELMKLRNKRETKMRGMMAKQEG 191
               EK + +          K + N NQ N    IL  E   +      K++ +    + 
Sbjct: 284 CEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKE 343

Query: 192 MEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETE----KLLEYIEEISCASDQ 247
           +E +  + +  +        +LE     I+ E   E+ + E    +LL   EE  C    
Sbjct: 344 LESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCV--- 400

Query: 248 VEKYKLDIAQLEEN----LKEKNDEILSLKQSLEENIVILSK---------------QVE 288
           +EK K ++A L +     +++ N E+ SLK+  ++ I  L++               +++
Sbjct: 401 IEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQ 460

Query: 289 DLNVKCQLLEKEKEDHVNRNREHNE--------------NLNAEMQNLKQKFILEQQE-R 333
            L  +C+ L++EK++ +       E               ++ E +++KQ+   +  E +
Sbjct: 461 GLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQ 520

Query: 334 EKLQQKELQIDSLLQ-------------QEKELSSSLHQKLCSFQEE------------- 367
           +KL+    + D+LL+              ++EL   L   + + QE+             
Sbjct: 521 QKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDT 580

Query: 368 -----------MVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKL 416
                      + +EK+ F  +LK + +E+D   +K E+ ERL+ +L ++ +   +    
Sbjct: 581 MLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSE 640

Query: 417 LEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFE---SYKALTASEIED 473
           LE+K+      LE++          L+EK D   Q LE +  Q +     K + ++E++ 
Sbjct: 641 LEQKVNELTGGLEET----------LKEK-DQNDQKLEKLMVQMKVLSEDKEVLSAEVKS 689

Query: 474 LKLENSSLQEKAAKAGKNAE---DVQHQILATESSNQEYVRMLLDLQTKSAL-KETEIKE 529
           L  EN+ L  +  +  ++ E     +  ++  E   Q   ++ L ++ +  L K  E ++
Sbjct: 690 LYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQ 749

Query: 530 ITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYN 589
           +   F          +K Q   F K++  E    +E+++    L         + EE  N
Sbjct: 750 VQKLF----------VKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCN 799

Query: 590 KTKPFQLQLDAFEVEKQ-ALLNEHGAAQ-EQLNKIRDSYAKLLGHQNLKQKIKHVVKLKD 647
               FQ      E+EK+   L E    Q E+L  +   Y             +  V L+ 
Sbjct: 800 LA--FQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYE------------QEKVLLRK 845

Query: 648 ENSQLKSEVSKLRCQLAKKKQSETKLQ-EELNKVLGIKHFDP--SKAFHHESKENFALK 703
           E  +++SE   L+  L + K +  K + E  N ++ ++      SK+  H  KE   +K
Sbjct: 846 ELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIK 904



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 102/539 (18%), Positives = 235/539 (43%), Gaps = 66/539 (12%)

Query: 175 RNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKL 234
           ++K ET  +  + K    +M L      +++++ +  +LE ++     E++  K  TE  
Sbjct: 19  KSKLETLPKEDLIKFAKKQMML------IQKAKSRCTELEKEI-----EELRSKPVTEGT 67

Query: 235 LEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKC 294
            + I+ ++   ++++   L+ A+ E+       E + +KQ +E+++  +    ++L    
Sbjct: 68  GDIIKALT---ERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKEL---- 120

Query: 295 QLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELS 354
                 ++ H+N  +E  ENL  E+  ++ K+  ++   +K  ++ +     L ++ +  
Sbjct: 121 ------EQSHINYVKEI-ENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQ 173

Query: 355 SSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD-KLQQKEEQAERLVKQLEEEAK----- 408
           ++    +   QEE+ K +  FEE++     +LD    +K+E   +L   +E  ++     
Sbjct: 174 NNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKN 233

Query: 409 --SRAEELKLL----EEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLE-------- 454
             S  EEL  L    +E++K    ++E S+  H      L E  +++V+  E        
Sbjct: 234 INSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQK 293

Query: 455 DVTAQFESYKALTASEIED------LKLENSSLQEKAAKAGKNAEDVQHQILATESSNQE 508
               + E+ +  T++  +D      L  EN+ +++   +  K+ ED   ++ +  S  ++
Sbjct: 294 KYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKD 353

Query: 509 YVRMLLDLQTKSALKETEIKEITVSFLQKITDLQ---NQLKQQEEDFRKQLEDEEGRKAE 565
            V  + +L+ K  +    IK+    F  +  DL+   N+L   +E+    +E  +   A 
Sbjct: 354 EVTYMNNLKLKLEMDAQHIKD---EFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAG 410

Query: 566 KENTTAELTEEINKWRLLYEELYNK--TKPFQLQLDAFEVEKQALLNEHGAAQEQLNKI- 622
                    E+ N+     +E + K  ++  +  L   E EK  L+ E    +EQ   + 
Sbjct: 411 LNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQ 470

Query: 623 RDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVL 681
           ++    +L +++L++ ++ +       ++L     K+  +    KQ +     EL + L
Sbjct: 471 QEKQEAILNYESLREIMEIL------QTELGESAGKISQEFESMKQQQASDVHELQQKL 523


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score =  123 bits (308), Expect = 7e-28
 Identities = 121/546 (22%), Positives = 249/546 (45%), Gaps = 50/546 (9%)

Query: 172  MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 229
            MKL  K +  ++    ++E   MK   + T+  L +++ K  +LE K+V++ +EK D + 
Sbjct: 834  MKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQL 893

Query: 230  ETEKLLEYIEEISCASDQVEKYKL-------DIAQLEENLKEKNDEILSLKQSLEENIVI 282
            + +   + + +     DQ+ K K+       ++ +  E+ +E N E+ + K+ LE+    
Sbjct: 894  QVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 953

Query: 283  LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQ 342
            L K ++DL +    +EKEK  H   N+   +NL  EM  L +      +E++ LQ+   Q
Sbjct: 954  LKKDIDDLELTLAKVEKEK--HATENKV--KNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1009

Query: 343  IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQ 402
                LQ E++  ++L +     ++++   +   E+E K  +D    L++ + + E  +K 
Sbjct: 1010 TLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMD----LERAKRKLEGDLKL 1065

Query: 403  LEEEAKSRAEELKLLEEKLKGKEAELE--KSSAAHTQA-TLLLQEKYDSMVQSLEDVTAQ 459
             +E       + + L EKLK KE E+   +      QA  + LQ+K   +   +E++  +
Sbjct: 1066 AQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEE 1125

Query: 460  FESYKALTA---SEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDL 516
             E+ +A  A    +  DL  E   + E+  +AG        QI   +    E+ +M  DL
Sbjct: 1126 IEAERASRAKAEKQRSDLSRELEEISERLEEAG---GATSAQIEMNKKREAEFQKMRRDL 1182

Query: 517  QTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEE 576
            +  +   E     +       + +L  Q+   +   +++LE E+     + N  A   E 
Sbjct: 1183 EESTLQHEATAAALRKKHADSVAELGEQIDSLQR-VKQKLEKEKSELKMEINDLASNMET 1241

Query: 577  INKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLL------ 630
            ++K +  +E++    +    ++   E E+Q L+NE  A + +L+     +++ L      
Sbjct: 1242 VSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAM 1301

Query: 631  ------GHQNLKQKIKHVVKLKDENSQLKSEVSK-----------LRCQLAKKKQSETKL 673
                  G Q   Q+I+ + +  +E ++ KS ++            LR Q  ++++++ +L
Sbjct: 1302 VSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAEL 1361

Query: 674  QEELNK 679
            Q  ++K
Sbjct: 1362 QRGMSK 1367



 Score =  111 bits (278), Expect = 2e-24
 Identities = 146/706 (20%), Positives = 292/706 (41%), Gaps = 107/706 (15%)

Query: 68   KVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREK 127
            K +  ++K+E  K +   K LE+++  L+QE+     ++Q     L   E R +  ++ K
Sbjct: 857  KEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTK 916

Query: 128  TSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMA 187
              L A      K++ E     E + +                EL   + K E +   +  
Sbjct: 917  IQLEAK----IKEVTERAEDEEEINA----------------ELTAKKRKLEDECSELKK 956

Query: 188  KQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQ 247
              + +E+ L   ++    ++ K+  L  ++  ++ E I + ++ +K L+          +
Sbjct: 957  DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD-ETIAKLTKEKKALQ----------E 1005

Query: 248  VEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNR 307
              +  LD  Q+EE   +K + +   K  LE+ +  L   +E     C  LE+ K      
Sbjct: 1006 AHQQTLDDLQMEE---DKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAK------ 1056

Query: 308  NREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSL---LQQEKELSSSLHQKLCSF 364
             R+   +L    ++       +QQ  EKL++KE ++ +L   ++ E+ L+  L +K+   
Sbjct: 1057 -RKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKEL 1115

Query: 365  QEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEEL---KLLEEKL 421
            Q  + + +   E E         +      + E + ++LEE   + + ++   K  E + 
Sbjct: 1116 QARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEF 1175

Query: 422  KGKEAELEKSSAAHTQATLLLQEKY-DSM------VQSLEDVTAQFESYKALTASEIEDL 474
            +    +LE+S+  H      L++K+ DS+      + SL+ V  + E  K+    EI DL
Sbjct: 1176 QKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDL 1235

Query: 475  KLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEIT--- 531
                 ++ +  A   K    ++ Q+   ++  +E  R++ +L  + A   TE  E +   
Sbjct: 1236 ASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQL 1295

Query: 532  --------------VSFLQKITDLQNQLKQQEED-----------------FRKQLEDEE 560
                           +F Q+I +L+ QL+++ +                   R+Q E+E+
Sbjct: 1296 DEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQ 1355

Query: 561  GRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLN 620
              KAE +   ++   E+ +WR  YE     T   Q + +  E  K+ L      A+E + 
Sbjct: 1356 EAKAELQRGMSKANSEVAQWRTKYE-----TDAIQ-RTEELEEAKKKLAQRLQDAEEHVE 1409

Query: 621  KIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRC-QLAKKKQSETKLQEELNK 679
             +    A L   +  KQ++++ V    E+  +  E S   C  L KK+++  K+  E  +
Sbjct: 1410 AVNSKCASL---EKTKQRLQNEV----EDLMIDVERSNAACIALDKKQRNFDKVLAEWKQ 1462

Query: 680  VLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQESWK 725
                K+ +         KE+ +L T L +   N Y   ++  E+ K
Sbjct: 1463 ----KYEETQAELEASQKESRSLSTELFKVK-NAYEESLDHLETLK 1503



 Score =  105 bits (261), Expect = 2e-22
 Identities = 140/685 (20%), Positives = 307/685 (44%), Gaps = 71/685 (10%)

Query: 47   QKESKQNLNVDK-DTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRR 105
            ++E K  +++++    L    +  + S    E+ K   + K+ +KE  +   +   +D +
Sbjct: 1043 EQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQ 1102

Query: 106  IQ--DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKN 163
                 L+ ++++++AR+     E  +  A+ A  EKQ  +L+R  E +  +  E G   +
Sbjct: 1103 ALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1162

Query: 164  LRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG-KIAQLEGKLVSIEK 222
             +I      ++  KRE + + M    E   ++ + T  +L +     +A+L  ++ S+++
Sbjct: 1163 AQI------EMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQR 1216

Query: 223  EKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVI 282
             K   + E  +L   I +++   + V K K +  ++   L+++  EI + ++  +  I  
Sbjct: 1217 VKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINE 1276

Query: 283  LSKQVEDLNVKCQLLEK---EKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREK---- 335
            LS Q   L+ +     +   EK+  V++     +    +++ LK++  LE++ + K    
Sbjct: 1277 LSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQ--LEEETKAKSTLA 1334

Query: 336  --LQQKELQIDSLLQQ---EKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD--- 387
              LQ      D L +Q   E+E  + L + +     E+ + +  +E +  Q  +EL+   
Sbjct: 1335 HALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAK 1394

Query: 388  -KLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKY 446
             KL Q+ + AE  V+ +  +  S  +  + L+ +++    ++E+S+A    A + L +K 
Sbjct: 1395 KKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNA----ACIALDKKQ 1450

Query: 447  DSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSN 506
                ++ + V A+++     T +E+E  + E+ SL  +  K     E+    +   +  N
Sbjct: 1451 ----RNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKREN 1506

Query: 507  QEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGR---- 562
            +   + + DL  + A     I E+     +++   +++L+   E+    LE EEG+    
Sbjct: 1507 KNLQQEISDLTEQIAEGGKHIHELE-KVKKQLDHEKSELQTSLEEAEASLEHEEGKILRI 1565

Query: 563  -------KAEKENTTAELTEEINKWR---LLYEELYNKTKPFQLQL--DAFEVEK--QAL 608
                   K+E +   AE  EE+++ +   L   E    T   +++   DA  ++K  +  
Sbjct: 1566 QLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGD 1625

Query: 609  LNE--------HGAAQEQLNKIRDSYAKLLGHQ-NLKQKIKHVVKLKDENSQ-------L 652
            LNE        +  A E L  +R++   L   Q +L   I+    LK++ +        +
Sbjct: 1626 LNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLM 1685

Query: 653  KSEVSKLRCQLAKKKQSETKLQEEL 677
            ++EV +LR  L + ++     ++EL
Sbjct: 1686 QAEVEELRASLERTERGRKMAEQEL 1710



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 143/661 (21%), Positives = 283/661 (42%), Gaps = 100/661 (15%)

Query: 39   QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQE 98
            Q+++   Q+  SK N  V +  T   +    ++ E ++  +K  + L+  E+ +  +  +
Sbjct: 1355 QEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSK 1414

Query: 99   RGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSEN 158
              + ++  Q L+ E+E +   +  +     +L       +K L E  +  E  +++    
Sbjct: 1415 CASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELE-- 1472

Query: 159  GNQKNLRILSLELMKLRNKRETKMRGMMA-KQEGMEMKLQVTQRSLEESQG--KIAQLEG 215
             +QK  R LS EL K++N  E  +  +   K+E   ++ +++  + + ++G   I +LE 
Sbjct: 1473 ASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELE- 1531

Query: 216  KLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQS 275
                ++K+   EKSE +  LE  E    AS + E+ K+   QLE N          +K  
Sbjct: 1532 ---KVKKQLDHEKSELQTSLEEAE----ASLEHEEGKILRIQLELN---------QVKSE 1575

Query: 276  LEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREK 335
            ++  I    ++++ L          K +H+         L+AE+++      ++++    
Sbjct: 1576 IDRKIAEKDEELDQL----------KRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGD 1625

Query: 336  LQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQ 395
            L + E+Q++   +Q  E   +L        + ++K+  L    L   +   D L+++   
Sbjct: 1626 LNEMEIQLNHANRQAAEALRNLRNT-----QGILKDTQL---HLDDAIRGQDDLKEQLAM 1677

Query: 396  AERLVKQLEEEAKSRAEELKLLEEKLKGKEAEL----EKSSAAHTQATLLLQEKYDSMVQ 451
             ER    ++ E +     L+  E   K  E EL    E+    HTQ T L+  K     +
Sbjct: 1678 VERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTK-----K 1732

Query: 452  SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR 511
             LE   +Q +        E+ED+  E  + +EKA KA  +A  +  ++   + ++    R
Sbjct: 1733 KLETDISQIQG-------EMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1785

Query: 512  M-------------LLDLQTKSALK--ETEIKEITVSFLQKITDLQNQLKQQEEDFRKQL 556
            M              LD   + ALK  + +I+++     +  ++++++ K   E   K L
Sbjct: 1786 MKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAV-KGL 1844

Query: 557  EDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQ 616
               E R  E    T E  + I + + L ++L  K K ++ Q  A E E+Q+ +N      
Sbjct: 1845 RKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQ--AEEAEEQSNVN------ 1896

Query: 617  EQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL-KSEVSKLRCQLAKKKQSETKLQE 675
              L K R              K++H ++   E + + +S+V+KLR    K ++  TK+  
Sbjct: 1897 --LAKFR--------------KLQHELEEAKERADIAESQVNKLR---VKSREVHTKVIS 1937

Query: 676  E 676
            E
Sbjct: 1938 E 1938



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 90/435 (20%), Positives = 189/435 (43%), Gaps = 54/435 (12%)

Query: 22   GAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTL--PASARKVKSSESKKESQ 79
            G   +  LE +K  +  +KS+     +E++ +L  ++   L       +VKS   +K ++
Sbjct: 1523 GGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAE 1582

Query: 80   KNDKDLKILEKEIRVLLQERGAQDRRIQD----------LETELEKMEARLNAALREKTS 129
            K+++  ++    +RV+   +   D  I+           +E +L +ME +LN A R+   
Sbjct: 1583 KDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAE 1642

Query: 130  LSANNATLEK-------QLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKM 182
               N    +         L +  R  + LK + +    + NL  +  E+ +LR   E   
Sbjct: 1643 ALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANL--MQAEVEELRASLERTE 1700

Query: 183  RGM-MAKQEGMEMKLQV------------TQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 229
            RG  MA+QE ++   +V            T++ LE     I+Q++G++  I +E    ++
Sbjct: 1701 RGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETD---ISQIQGEMEDIVQEA---RN 1754

Query: 230  ETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVED 289
              EK  + I + +  +++++K +   A LE   K     +  L+  L+E   +  K  + 
Sbjct: 1755 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK 1814

Query: 290  LNVKCQLLEKEKEDHVNRNREHN----ENLNAEMQNLKQKFILEQQEREKLQQKELQIDS 345
               K +   +E E  V   ++HN    + L    + +K+     +++R+ + + +  +D 
Sbjct: 1815 QIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDK 1874

Query: 346  LLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEE 405
            L  + K              EE  ++ N+   + ++   EL++ +++ + AE  V +L  
Sbjct: 1875 LQTKVKAYKRQ--------AEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKL-- 1924

Query: 406  EAKSRAEELKLLEEK 420
              KSR    K++ E+
Sbjct: 1925 RVKSREVHTKVISEE 1939


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  122 bits (307), Expect = 9e-28
 Identities = 172/744 (23%), Positives = 319/744 (42%), Gaps = 122/744 (16%)

Query: 40   KSQRFKQQKESKQNLNVDKDT-TLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQE 98
            +S++  + K  KQ  ++ ++   L         + + ++  +  ++ ++ E + + L +E
Sbjct: 1128 ESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELK-KALEEE 1186

Query: 99   RGAQDRRIQDLE----TELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSK 154
                + +IQD+     T LE++  +L  A R K +L  N   LE    EL    ++L+  
Sbjct: 1187 TKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQV 1246

Query: 155  FSENGNQKN------------------LRI-LSLELMKLRNK--------RETKMRGMMA 187
             +E+ +++                   LR+ L+ +  KL+N+         E + +G+  
Sbjct: 1247 KAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKF 1306

Query: 188  KQEG--MEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCAS 245
             ++   +E +LQ TQ  L+E   +   L  ++  +E+EK         L E  EE   A 
Sbjct: 1307 AKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEK-------NSLQEQQEEEEEAR 1359

Query: 246  DQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHV 305
              +EK  L +     + K+K D+ L   +SLEE    L K  E L+ + +    EK    
Sbjct: 1360 KNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLE----EKALAY 1415

Query: 306  NRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK----- 360
            ++  +    L  E+ +L      ++Q    L++K+ + D LL +EK +S+   ++     
Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAE 1475

Query: 361  ------------LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAK 408
                        L    EE ++ K  FE + KQ   +++ L   ++   + V +LE+  +
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKR 1535

Query: 409  SRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTA 468
            +  ++++ +  +L+  E EL+ +  A  +  + +Q       + L+    Q E  K L  
Sbjct: 1536 ALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI 1595

Query: 469  SEIEDL--KLENSSLQEKAAKAGK-----NAEDVQHQILATESSNQEYVRMLLDLQTKSA 521
             ++ +L  +LE+   Q   A A K     + +D++ QI A   +  E ++ L  LQ +  
Sbjct: 1596 KQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK 1655

Query: 522  LKETEIKEITVS----FLQ-------------KITDLQNQLKQQE------EDFRKQLED 558
              + E++E   S    F Q             +I  LQ +L   E      E  R +L D
Sbjct: 1656 DYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELAD 1715

Query: 559  E-----EGRKA---EK---ENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQA 607
            E      G+ A   EK   E   A+L EE+ + +   E L ++ +   LQ+D    E   
Sbjct: 1716 EITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAE--- 1772

Query: 608  LLNEHGAAQEQLNKIRDSYAKLLGHQN--LKQKIKHV-----VKLKDENSQLKSEVSKLR 660
            L  E  AAQ+      D+  + L  QN  LK K++ +      K K   S L++++ +L 
Sbjct: 1773 LAAERSAAQKS-----DNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLE 1827

Query: 661  CQL---AKKKQSETKLQEELNKVL 681
             QL   AK++ +  KL     K L
Sbjct: 1828 EQLEQEAKERAAANKLVRRTEKKL 1851



 Score =  108 bits (269), Expect = 2e-23
 Identities = 140/660 (21%), Positives = 305/660 (46%), Gaps = 58/660 (8%)

Query: 39   QKSQRFKQQKESKQNLNVDK---DTTLPASARKVKSSESKKESQK----NDKDLKILEKE 91
            ++ +R  QQ   ++N+  ++   +T L A A ++++  + K+ +     +D + ++ E+E
Sbjct: 876  EEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEE 935

Query: 92   IR--VLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN- 148
             R  +L  E+      IQDLE +L++ E        EK +  A    +E++++ L   N 
Sbjct: 936  ERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNS 995

Query: 149  ------ELLKSKFSENGNQ-KNLRILSLELMKLRNKRETKMRGM---MAKQEGMEMKLQV 198
                  +L++ + +E  +Q       +  L K+RNK+E  +  +   + K+E    +L+ 
Sbjct: 996  KFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEK 1055

Query: 199  TQRSLE----ESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISC----ASDQVEK 250
             +R L+    + Q +IA+L+ ++  ++ +   ++ E +  L   ++ +     A   V +
Sbjct: 1056 AKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRE 1115

Query: 251  YKLDIAQLEENL---KEKNDEILSLKQSLEENIVILSKQVE---DLNVKCQLLEKEKEDH 304
             +  IA+L+E+    K   ++    K+ L E +  L  ++E   D     Q L  ++E  
Sbjct: 1116 LQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQE 1175

Query: 305  VNRNR----EHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 360
            V   +    E  +N  A++Q+++Q+     +E  +  ++  +  + L++ K+   + +++
Sbjct: 1176 VAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKE 1235

Query: 361  LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 420
            L    + + + K   E + K+   ++ +L  K  + +RL  +L E+A     EL  +   
Sbjct: 1236 LACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTL 1295

Query: 421  LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS 480
            L  +EAE +    A   A+L      +S +Q  +++  +    K   +S I  L+ E +S
Sbjct: 1296 L--EEAEKKGIKFAKDAASL------ESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNS 1347

Query: 481  LQEKAAKAGKNAEDVQHQILATESSNQEYVRML-LDLQTKSALKETEIKEITVSFLQKIT 539
            LQE+  +  +  ++++ Q+LA +S   +  + +  DL T  +L+E +         +K+ 
Sbjct: 1348 LQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAK---------KKLL 1398

Query: 540  DLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLD 599
                 L Q+ E+     +  E  K   +    +LT +++  R +   L  K K F  QL 
Sbjct: 1399 KDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFD-QLL 1457

Query: 600  AFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKL 659
            A E    A   E     E   + +++ A  L  + L++ ++   + + +N QL++++  L
Sbjct: 1458 AEEKSISARYAEERDRAEAEAREKETKALSLA-RALEEALEAKEEFERQNKQLRADMEDL 1516



 Score =  102 bits (255), Expect = 1e-21
 Identities = 171/742 (23%), Positives = 318/742 (42%), Gaps = 125/742 (16%)

Query: 72   SESKKESQKNDKDL-KILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSL 130
            +  ++E Q  D++L K+ EK+ +V               E ELE+ME +    L EK  L
Sbjct: 848  TRQEEELQAKDEELLKVKEKQTKV---------------EGELEEMERKHQQLLEEKNIL 892

Query: 131  SAN--------------NATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRN 176
            +                 A L  +  EL      L+S+  E   ++  +IL  E  K++ 
Sbjct: 893  AEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEE--EEERNQILQNEKKKMQA 950

Query: 177  KRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLE 236
              +  +   + ++EG   KLQ+ + + E    KI ++E +++ +E +  + K   EK L 
Sbjct: 951  HIQ-DLEEQLDEEEGARQKLQLEKVTAE---AKIKKMEEEILLLEDQ--NSKFIKEKKLM 1004

Query: 237  YIEEISCASDQVE-------------KYKLDIAQLEENLKEK---NDEILSLKQSLEENI 280
                  C+S   E             K ++ I+ LEE LK++     E+   K+ L+   
Sbjct: 1005 EDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGET 1064

Query: 281  VILSKQVEDL-----NVKCQLLEKEKE------------DHVNRNREHNENLNAEMQNLK 323
              L  Q+ +L      +K QL +KE+E             H N   +    L A++  L+
Sbjct: 1065 TDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQ 1124

Query: 324  QKFILEQQEREKLQQKELQIDSLLQQEK-ELSSSL-----HQKLCSFQEEMVKE-KNLFE 376
            + F  E+  R K ++++  +   L+  K EL  +L      Q+L + +E+ V E K   E
Sbjct: 1125 EDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALE 1184

Query: 377  EELKQTLDELDKLQQKEEQA-ERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAH 435
            EE K    ++  ++Q+   A E L +QLE+  + +A     LE+  +G E +  K  A  
Sbjct: 1185 EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKAN----LEKNKQGLETD-NKELACE 1239

Query: 436  TQATLLL-------QEKYDSMVQSLEDVTAQFESYKALTASEIEDL--KLEN-SSLQEKA 485
             +    +       ++K D+ VQ L    ++ +  +   A +   L  +L+N S+L E+A
Sbjct: 1240 VKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEA 1299

Query: 486  AKAG----KNAEDVQHQILATESSNQEYVRMLLDL--------QTKSALKE--TEIKEIT 531
             K G    K+A  ++ Q+  T+   QE  R  L+L        + K++L+E   E +E  
Sbjct: 1300 EKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEAR 1359

Query: 532  VSFLQKITDLQNQL---KQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELY 588
             +  +++  LQ+QL   K++ +D    +E  E  K +       L++ + +  L Y++L 
Sbjct: 1360 KNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLE 1419

Query: 589  NKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQN------LKQKIKHV 642
                  Q +LD   V+    L+        L K +  + +LL  +        +++ +  
Sbjct: 1420 KTKNRLQQELDDLTVD----LDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAE 1475

Query: 643  VKLKDENSQLKSEVSKLRCQLAKKKQSE---TKLQEELNKVLGIKHFDPSKAFHHESKEN 699
             + +++ ++  S    L   L  K++ E    +L+ ++  ++  K  D  K  H   K  
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKD-DVGKNVHELEKSK 1534

Query: 700  FALKTPLKEGNTNCYRAPMECQ 721
             AL+  ++E  T       E Q
Sbjct: 1535 RALEQQVEEMRTQLEELEDELQ 1556



 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 101/462 (21%), Positives = 210/462 (45%), Gaps = 78/462 (16%)

Query: 41   SQRFKQQKESKQNLNVDKDTTLPASARKVKSS-ESKKESQKNDKDLKI-----------L 88
            S R+ ++++  +    +K+T   + AR ++ + E+K+E ++ +K L+            +
Sbjct: 1464 SARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDV 1523

Query: 89   EKEIRVLLQERGAQDRRIQDLETELEKMEARLNAA----LREKTSLSANNATLEKQLIEL 144
             K +  L + + A +++++++ T+LE++E  L A     LR + ++ A  A  E+ L   
Sbjct: 1524 GKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTR 1583

Query: 145  TRTNEL-----------LKSKFSENGNQKNLRILSLELMKLRNK-------RETKMRGMM 186
               NE            L+++  +   Q+ L + S + M++  K          K R  +
Sbjct: 1584 DEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEV 1643

Query: 187  AKQ-EGMEMKLQVTQRSLEES---------------------QGKIAQLEGKLVSIEKEK 224
             KQ   ++ +++  QR LEE+                     + +I QL+ +L S E+ +
Sbjct: 1644 IKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERAR 1703

Query: 225  IDEKSETEKLLEYIEEI----SCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENI 280
               + E ++L + I       S   D+  + +  IAQLEE L+E+   +  L     +  
Sbjct: 1704 RHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTT 1763

Query: 281  VILSKQVEDLNVK--CQLLEKEKEDHVNRNREH-NENLNAEMQNL----KQKFILEQQER 333
            +    QV+ LN +   +    +K D+  +  E  N+ L A++Q L    K KF   +   
Sbjct: 1764 L----QVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKF---KATI 1816

Query: 334  EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKE 393
              L+ K  Q++  L+QE +  ++ + KL    E+ +KE  +  E+ ++     D+ +++ 
Sbjct: 1817 SALEAKIGQLEEQLEQEAKERAAAN-KLVRRTEKKLKEIFMQVEDERR---HADQYKEQM 1872

Query: 394  EQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAH 435
            E+A   +KQL+ + +   EE        +  + EL+ ++ A+
Sbjct: 1873 EKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEAN 1914



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 100/410 (24%), Positives = 174/410 (42%), Gaps = 49/410 (11%)

Query: 283  LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ---EREKLQQK 339
            +++Q E+L  K + L K KE       E  E      Q L++K IL +Q   E E   + 
Sbjct: 847  VTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEA 906

Query: 340  ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL 399
            E     L  +++EL   LH       E  V+E    EEE  Q L    K  Q   Q   L
Sbjct: 907  EEMRARLAAKKQELEEILHDL-----ESRVEE----EEERNQILQNEKKKMQAHIQD--L 955

Query: 400  VKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQ 459
             +QL+EE  +R             ++ +LEK +A   +A +   +K +  +  LED  ++
Sbjct: 956  EEQLDEEEGAR-------------QKLQLEKVTA---EAKI---KKMEEEILLLEDQNSK 996

Query: 460  FESYKALTASEIEDLKLENSSLQEKAAKAGK--NAEDVQHQILATESSNQEYVRMLLDLQ 517
            F   K L    I +   + +  +EKA    K  N ++V    L      +E  R  L+  
Sbjct: 997  FIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKA 1056

Query: 518  TKSALKETEIKEITVSFLQ-KITDLQNQLKQQEEDFRKQLEDEEGRKAEKENT------- 569
             +    ET   +  ++ LQ +I +L+ QL ++EE+ +  L   +     K N        
Sbjct: 1057 KRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVREL 1116

Query: 570  ---TAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSY 626
                AEL E+    +    +   + +    +L+A + E +  L+   A QE   K     
Sbjct: 1117 QAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEV 1176

Query: 627  AKLLGHQNLKQKIK-HVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 675
            A+L   + L+++ K H  +++D   +  + + +L  QL + K+ +  L++
Sbjct: 1177 AEL--KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEK 1224



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 82/400 (20%), Positives = 178/400 (44%), Gaps = 41/400 (10%)

Query: 333  REKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLF-----EEELKQTLDELD 387
            R+   +K+ Q+ +L   ++  ++ L  +   +     K K L      EEEL+   +EL 
Sbjct: 803  RKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELL 862

Query: 388  KLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLK------GKEAELEKSSAAHTQATLL 441
            K+++K+ + E  ++++E + +   EE  +L E+L+       +  E+    AA  Q    
Sbjct: 863  KVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEE 922

Query: 442  LQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLE-------NSSLQEKAAKAGKNAED 494
            +    +S V+  E+     ++ K    + I+DL+ +          LQ +   A    + 
Sbjct: 923  ILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKK 982

Query: 495  VQHQILATESSNQEYV--RMLLD---LQTKSALKETEIKEITVSFLQK-----ITDLQNQ 544
            ++ +IL  E  N +++  + L++    +  S L E E K   ++ ++      I+DL+ +
Sbjct: 983  MEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEER 1042

Query: 545  LKQQE---EDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAF 601
            LK++E   ++  K     +G   + ++  AEL  +I++ +L   +   + +    + D  
Sbjct: 1043 LKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDE 1102

Query: 602  EVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRC 661
             + K   L      Q Q+ ++++ +      +N  +K K    L +E   LK+E+     
Sbjct: 1103 TLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKR--DLSEELEALKTELEDTLD 1160

Query: 662  QLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFA 701
              A +++  TK ++E+ ++         KA   E+K + A
Sbjct: 1161 TTAAQQELRTKREQEVAEL--------KKALEEETKNHEA 1192



 Score = 69.7 bits (169), Expect = 9e-12
 Identities = 84/403 (20%), Positives = 174/403 (43%), Gaps = 27/403 (6%)

Query: 48   KESKQNLNVDKDTTLPASARKVKSSESKKESQKN--DKDLKILEKEIRVLLQERGAQDRR 105
            +++K  L V+         R +++ + + E +K    K ++ LE E+    ++R      
Sbjct: 1559 EDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVAS 1618

Query: 106  IQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSE-----NGN 160
             + +E +L+ +EA++ AA + +  +      L+ Q+ +  R  E  ++   E       +
Sbjct: 1619 KKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKES 1678

Query: 161  QKNLRILSLELMKLRNKRETKMRGMM-AKQEGMEMKLQVTQRSLEESQ--GKIAQLEGKL 217
            +K L+ L  E+++L+ +  +  R    A+QE  E+  ++T  +  +S    +  +LE ++
Sbjct: 1679 EKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARI 1738

Query: 218  VSIEKEKIDEKSETEKLLEYIEEISCASDQVEKY---KLDIAQLEEN----LKEKNDEIL 270
              +E+E  +E+S  E L +   + +   D +      +   AQ  +N    L+ +N E+ 
Sbjct: 1739 AQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELK 1798

Query: 271  SLKQSLEENIVILSKQ-VEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILE 329
            +  Q LE  +    K  +  L  K   LE++ E         N+ +    + LK+ F+  
Sbjct: 1799 AKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQV 1858

Query: 330  QQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKL 389
            + ER    Q + Q++    + K+L   L +      EE     N    +L++   ELD  
Sbjct: 1859 EDERRHADQYKEQMEKANARMKQLKRQLEE-----AEEEATRANASRRKLQR---ELDDA 1910

Query: 390  QQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSS 432
             +  E   R V  L+   + R   +     +   ++  LE +S
Sbjct: 1911 TEANEGLSREVSTLKNRLR-RGGPISFSSSRSGRRQLHLEGAS 1952


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score =  122 bits (305), Expect = 2e-27
 Identities = 134/550 (24%), Positives = 258/550 (46%), Gaps = 58/550 (10%)

Query: 172  MKLRNKRETKMRGMMAKQEGMEMKLQV--TQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 229
            MKL  K +  ++    ++E   MK +    + +LE+S+ +  +LE K+VS+ +EK D + 
Sbjct: 832  MKLYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQL 891

Query: 230  ETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKND----------EILSLKQSLEEN 279
            + +   + + +     DQ+ K K+   QLE  +KE N+          E+ + K+ LE+ 
Sbjct: 892  QVQAEQDNLNDAEERCDQLIKNKI---QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE 948

Query: 280  IVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK 339
               L K ++DL +    +EKEK  H   N+   +NL  EM  L +      +E++ LQ+ 
Sbjct: 949  CSELKKDIDDLELTLAKVEKEK--HATENKV--KNLTEEMAGLDEIIAKLTKEKKALQEA 1004

Query: 340  ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL 399
              Q    LQ E++  +SL +     ++++   +   E+E K  +D    L++ + + E  
Sbjct: 1005 HQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMD----LERAKRKLEGD 1060

Query: 400  VKQLEEEAKSRAEELKLLEEKLKGKEAEL-EKSSAAHTQATLLLQ-----EKYDSMVQSL 453
            +K  +E       +   LEEKLK KE ++ +++S    +  L LQ     ++  + ++ L
Sbjct: 1061 LKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEEL 1120

Query: 454  EDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRML 513
            E+      + +A       DL  E   + E+  +AG  A  V  QI   +    E+ +M 
Sbjct: 1121 EEELEAERTARAKVEKLRSDLSRELEEISERLEEAG-GATSV--QIEMNKKREAEFQKMR 1177

Query: 514  LDLQ--------TKSALKETEIKEITVSFLQKITDLQ---NQLKQQEEDFRKQLEDEEGR 562
             DL+        T +AL++     +     ++I +LQ    +L++++ +F+ +L+D    
Sbjct: 1178 RDLEEATLQHEATAAALRKKHADSV-AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSN 1236

Query: 563  -------KAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQAL---LNEH 612
                   KA  E  +  L ++ N++R+  EE       F  Q    + E   L   L E 
Sbjct: 1237 MEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEK 1296

Query: 613  GAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKK-QSET 671
             A   QL + + SY + +  ++LK++++   K K+  +    + ++  C L +++ + ET
Sbjct: 1297 EALISQLTRGKLSYTQQM--EDLKRQLEEEGKAKNALAH-ALQSARHDCDLLREQYEEET 1353

Query: 672  KLQEELNKVL 681
            + + EL +VL
Sbjct: 1354 EAKAELQRVL 1363



 Score =  114 bits (286), Expect = 2e-25
 Identities = 160/723 (22%), Positives = 302/723 (41%), Gaps = 102/723 (14%)

Query: 40   KSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQER 99
            K Q   + KE  + L  +++     +A+K K  +   E +K+  DL++   ++    +E+
Sbjct: 914  KIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVE---KEK 970

Query: 100  GAQDRRIQDLETELEKMEARLNAALREKTSLS-ANNATLEKQLIELTRTNELLKSKFS-- 156
             A + ++++L  E+  ++  +    +EK +L  A+   L+   +E  + N L KSK    
Sbjct: 971  HATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLE 1030

Query: 157  --------------------ENGNQK---NLRILSLELMKLRN----------KRETKMR 183
                                E   +K   +L++    +M L N          K+E  + 
Sbjct: 1031 QQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDIN 1090

Query: 184  GMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKL-------VSIEKEKIDEKSETEKLLE 236
               +K E  ++     Q+ L+E+Q +I +LE +L         +EK + D   E E++ E
Sbjct: 1091 QQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISE 1150

Query: 237  YIEEISCASD-QVEKYKLDIAQLEENLKEKNDEIL-------SLKQSLEENIVILSKQVE 288
             +EE   A+  Q+E  K   A+ ++  ++  +  L       +L++   +++  L +Q++
Sbjct: 1151 RLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQID 1210

Query: 289  DLNVKCQLLEKEKE------DHVNRNREHNENLNAEMQNLKQKFILEQQ----------- 331
            +L    Q LEKEK       D V  N E      A ++ + +   LE Q           
Sbjct: 1211 NLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRT--LEDQANEYRVKLEEA 1268

Query: 332  ---------EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQT 382
                     +R KLQ +  ++   L++++ L S L +   S+ ++M   K   EEE K  
Sbjct: 1269 QRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAK 1328

Query: 383  LDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLL 442
                  LQ      + L +Q EEE +++AE  ++L +          K      Q T  L
Sbjct: 1329 NALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEEL 1388

Query: 443  QEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILAT 502
            +E    + Q L+D     E+  A  +S    L+     LQ +      + E       A 
Sbjct: 1389 EEAKKKLAQRLQDAEEAVEAVNAKCSS----LEKTKHRLQNEIEDLMVDVERSNAAAAAL 1444

Query: 503  ESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGR 562
            +   + + ++L + + K    ++E++    S  ++   L  +L + +  + + LE  E  
Sbjct: 1445 DKKQRNFDKILAEWKQKYEESQSELE----SSQKEARSLSTELFKLKNAYEESLEHLETF 1500

Query: 563  KAEKENTTAE---LTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE-Q 618
            K E +N   E   LTE++ +      EL    K    QL+  ++E Q+ L E  A+ E +
Sbjct: 1501 KRENKNLQEEISDLTEQLGEGGKNVHELEKVRK----QLEVEKLELQSALEEAEASLEHE 1556

Query: 619  LNKIRDSYAKLLGHQNLKQKIKHVVKLKDEN-SQLKSEVSKLRCQLAKKKQSETKLQEEL 677
              KI  +    L    +K +I+  +  KDE   Q K    ++   L     +ET+ + E+
Sbjct: 1557 EGKILRAQ---LEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEV 1613

Query: 678  NKV 680
             +V
Sbjct: 1614 LRV 1616



 Score =  110 bits (275), Expect = 5e-24
 Identities = 142/690 (20%), Positives = 300/690 (43%), Gaps = 89/690 (12%)

Query: 89   EKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIEL-TRT 147
            EKE+  + +E G     ++  E   +++E ++ + L+EK  L       +  L +   R 
Sbjct: 848  EKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERC 907

Query: 148  NELLKSKFSENGNQKNL-------RILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQ 200
            ++L+K+K       K +         ++ EL   + K E +   +    + +E+ L   +
Sbjct: 908  DQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVE 967

Query: 201  RSLEESQGKIAQLEGKLVSIE----KEKIDEKSETEKLLEYIEEISCASDQV-----EKY 251
            +    ++ K+  L  ++  ++    K   ++K+  E   + ++++    D+V      K 
Sbjct: 968  KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKV 1027

Query: 252  KLD--IAQLEENLKEKNDEILSL---KQSLEENIVILSKQVEDL-NVKCQLLEKEKEDHV 305
            KL+  +  LE +L+++    + L   K+ LE ++ +  + + DL N K QL EK K+   
Sbjct: 1028 KLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEF 1087

Query: 306  NRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQ 365
            + N+++++        ++ + +L  Q ++KL++ + +I+  L++E E   +   K+   +
Sbjct: 1088 DINQQNSK--------IEDEQVLALQLQKKLKENQARIEE-LEEELEAERTARAKVEKLR 1138

Query: 366  EEMVKEKNLFEEELKQ----TLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKL 421
             ++ +E     E L++    T  +++  +++E + +++ + LEE           L +K 
Sbjct: 1139 SDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKH 1198

Query: 422  KGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESY---KALTASEIEDLKLEN 478
                AEL +      +    L+++       L+DVT+  E     KA        L+ + 
Sbjct: 1199 ADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQA 1258

Query: 479  SSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEIT---VSFL 535
            +  + K  +A ++  D   Q    ++ N E  R L +       KE  I ++T   +S+ 
Sbjct: 1259 NEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEE-------KEALISQLTRGKLSYT 1311

Query: 536  QKITDLQNQLKQQEED-----------------FRKQLEDEEGRKAEKENTTAELTEEIN 578
            Q++ DL+ QL+++ +                   R+Q E+E   KAE +   ++   E+ 
Sbjct: 1312 QQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVA 1371

Query: 579  KWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQK 638
            +WR  YE     T   Q + +  E  K+ L      A+E +  +    + L       +K
Sbjct: 1372 QWRTKYE-----TDAIQ-RTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSL-------EK 1418

Query: 639  IKHVVKLKDENSQLKSEVSKLRCQLA---KKKQSETKLQEELNKVLGIKHFDPSKAFHHE 695
             KH  +L++E   L  +V +     A   KK+++  K+  E  +    K+ +        
Sbjct: 1419 TKH--RLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQ----KYEESQSELESS 1472

Query: 696  SKENFALKTPLKEGNTNCYRAPMECQESWK 725
             KE  +L T L +   N Y   +E  E++K
Sbjct: 1473 QKEARSLSTELFK-LKNAYEESLEHLETFK 1501



 Score =  105 bits (263), Expect = 1e-22
 Identities = 152/687 (22%), Positives = 313/687 (45%), Gaps = 74/687 (10%)

Query: 42   QRFKQQKESKQN---LNVDKDTTLPASARKVKSSESKK----ESQKNDKDLKILE--KEI 92
            QR KQ+ E +++   L +D  T+      K K++  K     E Q N+  +K+ E  + +
Sbjct: 1213 QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSL 1272

Query: 93   RVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN---- 148
                 +R        +L  +LE+ EA ++   R K S +     L++QL E  +      
Sbjct: 1273 NDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALA 1332

Query: 149  ----------ELLKSKFSENGNQKN--LRILSL---ELMKLRNKRETKMRGMMAKQEGME 193
                      +LL+ ++ E    K    R+LS    E+ + R K ET    +   +E  E
Sbjct: 1333 HALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETD--AIQRTEELEE 1390

Query: 194  MKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 253
             K ++ QR L++++  +  +  K  S+EK K   ++E E L+  +E  + A+  ++K + 
Sbjct: 1391 AKKKLAQR-LQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR 1449

Query: 254  DIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNE 313
            +  ++    K+K +E  S  +S ++    LS ++     K +   +E  +H+   +  N+
Sbjct: 1450 NFDKILAEWKQKYEESQSELESSQKEARSLSTEL----FKLKNAYEESLEHLETFKRENK 1505

Query: 314  NLNAEMQNLKQ------KFILEQQE-REKLQQKELQIDSLLQQEKELSSSLHQKLCSFQE 366
            NL  E+ +L +      K + E ++ R++L+ ++L++ S L++ +        K+   Q 
Sbjct: 1506 NLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQL 1565

Query: 367  EMVKEKNLFEEELKQTLDELDKLQQKEEQ-AERLVKQLEEEAKSRAEELKLLEEKLKGKE 425
            E  + K   E +L +  +E+++ ++  ++  + L   L+ E +SR E L+ +++K++G  
Sbjct: 1566 EFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLR-VKKKMEGDL 1624

Query: 426  AELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKA 485
             E+E   +   +     Q++  S+   L+D   Q +   A+ A+  +DLK   + ++ + 
Sbjct: 1625 NEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDD--AVRAN--DDLKENIAIVERRN 1680

Query: 486  AKAGKNAEDVQHQILATESS----NQEYVR-----MLLDLQTKSALKETEIKEITVSFLQ 536
                   E+++  +  TE S     QE +       LL  Q  S + + +  E  ++ LQ
Sbjct: 1681 NLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQ 1740

Query: 537  -KITDLQNQLKQQEEDFRKQLEDEE--GRKAEKENTTAELTEEINKWRLLYEELYNKTKP 593
             ++ +   + +  EE  +K + D      + +KE  T+   E + K       +    K 
Sbjct: 1741 SEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK------NMEQTIKD 1794

Query: 594  FQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLK 653
             Q +LD  E E+ AL       ++QL K+     +L G    +QK ++   +K      +
Sbjct: 1795 LQHRLD--EAEQIAL----KGGKKQLQKLEARVRELEGELEAEQK-RNAESVKGMRKS-E 1846

Query: 654  SEVSKLRCQLAKKKQSETKLQEELNKV 680
              + +L  Q  + K++  +LQ+ ++K+
Sbjct: 1847 RRIKELTYQTEEDKKNLLRLQDLVDKL 1873



 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 90/453 (19%), Positives = 200/453 (44%), Gaps = 59/453 (13%)

Query: 37   SFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLL 96
            S +  + FK++ ++ Q    D    L    + V       E +K  K L++ + E++  L
Sbjct: 1493 SLEHLETFKRENKNLQEEISDLTEQLGEGGKNVH------ELEKVRKQLEVEKLELQSAL 1546

Query: 97   QERGA----QDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRT----- 147
            +E  A    ++ +I   + E  +++A +   L EK           +++++  +T     
Sbjct: 1547 EEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAE 1606

Query: 148  ----NELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQ-EGMEMKLQVTQRS 202
                NE+L+ K    G+        L  M+++     +M     KQ + ++  L+ TQ  
Sbjct: 1607 TRSRNEVLRVKKKMEGD--------LNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ 1658

Query: 203  LEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENL 262
            L+++      L+  +  +E+     ++E E+L   +E+   +    E+  ++ ++  + L
Sbjct: 1659 LDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLL 1718

Query: 263  KEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE----------DHVNRNREHN 312
              +N  +++ K+ +E ++  L  +VE+   +C+  E++ +          + + + ++ +
Sbjct: 1719 HSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTS 1778

Query: 313  ENLNAEMQNLKQ-----KFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQ-------- 359
             +L    +N++Q     +  L++ E+  L+  + Q+  L  + +EL   L          
Sbjct: 1779 AHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAES 1838

Query: 360  -KLCSFQEEMVKEKNLFEEELKQTL----DELDKLQQKEEQAERLVKQLEEEAKSRAEEL 414
             K     E  +KE     EE K+ L    D +DKLQ K +  +R  ++ EE+A +   + 
Sbjct: 1839 VKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKF 1898

Query: 415  KLLEEKLKGKEAELEKSSAAHTQATLLLQEKYD 447
            + ++ +L   EAE E++  A +Q   L  +  D
Sbjct: 1899 RKVQHEL--DEAE-ERADIAESQVNKLRAKSRD 1928


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  120 bits (302), Expect = 3e-27
 Identities = 158/752 (21%), Positives = 324/752 (43%), Gaps = 121/752 (16%)

Query: 40   KSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQK--NDKDLKILEKEIRV--L 95
            +SQ   ++ + ++ L  + +    A   + + +  K+E ++  +D + ++ E+E R   L
Sbjct: 875  QSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHL 934

Query: 96   LQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLI-------ELTRTN 148
              E+    + IQ+LE +LE+ E+       EK +  A    LE++ I       +L +  
Sbjct: 935  QAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEK 994

Query: 149  ELLKSKFSE-NGNQKNLRILSLELMKLRNKRE---TKMRGMMAKQEGMEMKLQVTQRSLE 204
            +LL+ + +E   N       S  L KL+NK E   T +   + ++E    +L+ T+R LE
Sbjct: 995  KLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLE 1054

Query: 205  -----------ESQGKIAQLEGKLVSIEKE------KIDE---------------KSETE 232
                       E Q +IA+L+ +L   E+E      +++E               +S+  
Sbjct: 1055 GDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQIS 1114

Query: 233  KLLEYIEEISCASDQVEKYKLDIAQLEENLK------------------EKNDEILSLKQ 274
            +L E +E    + ++ EK K D+ +  E LK                  ++  E+  LK+
Sbjct: 1115 ELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKK 1174

Query: 275  SLEENIVILSKQVEDLNVK-------------------------CQLLEKEKEDHVNR-- 307
            +LEE       Q++++  K                          Q LE E+ +  N   
Sbjct: 1175 TLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVK 1234

Query: 308  -------NREH-NENLNAEMQNLKQKFILEQQEREKLQQK--ELQID-----SLLQQEKE 352
                   + EH  + + A++Q L+ KF   ++ R +L  K  +LQ++      LL Q   
Sbjct: 1235 VLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDS 1294

Query: 353  LSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSR-- 410
             SS L +   + + ++   + L +EE +Q L    KL+Q E++     +QLEEE +++  
Sbjct: 1295 KSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHN 1354

Query: 411  -AEELKLLEEKLKGKEAELEKSSAAHTQATLL---LQEKYDSMVQSLEDVTAQF---ESY 463
              +++  L  ++   + ++E S      A  +   LQ+  + + Q  E+  A +   E  
Sbjct: 1355 LEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKT 1414

Query: 464  KALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALK 523
            K     E++DL ++    ++ A    K  +     +   ++ + +Y       + ++  K
Sbjct: 1415 KTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREK 1474

Query: 524  ETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLL 583
            ET+   +  + L++  + + +L++  + FR ++ED    K +   +  EL +        
Sbjct: 1475 ETKALSLARA-LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQ 1533

Query: 584  YEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVV 643
             EE+  + +  + +L A E  K  L     A + Q    RD   +    Q+ ++K + V 
Sbjct: 1534 VEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFE--RDLQGR--DEQSEEKKKQLVR 1589

Query: 644  KLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 675
            ++++  ++L+ E  +    +A +K+ E  L++
Sbjct: 1590 QVREMEAELEDERKQRSMAVAARKKLEMDLKD 1621



 Score =  118 bits (296), Expect = 2e-26
 Identities = 137/681 (20%), Positives = 310/681 (45%), Gaps = 63/681 (9%)

Query: 46   QQKESKQNLNVDKDTTLPASARKVKSS-ESKKESQKNDKDLKILEKEIRVLLQERGAQDR 104
            Q+   K +  V++        ++VK++ E  K++ +N++    L  E++VLLQ +G  + 
Sbjct: 1188 QEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGE--LANEVKVLLQGKGDSEH 1245

Query: 105  RIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGN-QKN 163
            + + +E +L++++ + N   R +T L+     L+   +EL     LL    S++    K+
Sbjct: 1246 KRKKVEAQLQELQVKFNEGERVRTELADKVTKLQ---VELDNVTGLLSQSDSKSSKLTKD 1302

Query: 164  LRILSLELM---KLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSI 220
               L  +L    +L  +   +   +  K + +E +    +  LEE +     LE ++ ++
Sbjct: 1303 FSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATL 1362

Query: 221  EKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENI 280
              +  D K + E      + + C  +  E+ K  + +  E L ++++E ++    LE+  
Sbjct: 1363 HAQVADMKKKME------DSVGCL-ETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTK 1415

Query: 281  VILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQERE----KL 336
              L ++++DL V     +++   ++ + ++  + L AE + +  K+  E+   E    + 
Sbjct: 1416 TRLQQELDDLLVDLDH-QRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREK 1474

Query: 337  QQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDK----LQQK 392
            + K L +   L++  E  + L +    F+ EM ++    ++++ +++ EL+K    L+Q+
Sbjct: 1475 ETKALSLARALEEAMEQKAELERLNKQFRTEM-EDLMSSKDDVGKSVHELEKSKRALEQQ 1533

Query: 393  EEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQS 452
             E+ +  +++LE+E ++  +    LE  L+  +A+ E+      + +   +EK   +V+ 
Sbjct: 1534 VEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQS---EEKKKQLVRQ 1590

Query: 453  LEDVTAQFE---SYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEY 509
            + ++ A+ E     +++  +  + L+++   L+     A KN ++   Q+   ++  ++ 
Sbjct: 1591 VREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDC 1650

Query: 510  VRMLLD---------LQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEE 560
            +R L D          Q K   K+ +  E  +  LQ+      + K+Q +  R +L DE 
Sbjct: 1651 MRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEI 1710

Query: 561  GRKAEK-----------ENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVE----- 604
               + K           E   A+L EE+ + +   E + ++ K   LQ+D    +     
Sbjct: 1711 ANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLER 1770

Query: 605  KQALLNEHGAAQ-EQLNK-IRDSYAKLLGHQNLKQKIKHV---VKLKDENSQLKSEVSKL 659
              A  NE+   Q E+ NK ++    ++ G    K K        K+     QL +E  + 
Sbjct: 1771 SHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKER 1830

Query: 660  RCQLAKKKQSETKLQEELNKV 680
            +    + +++E KL++ L +V
Sbjct: 1831 QAACKQVRRTEKKLKDVLLQV 1851



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 109/547 (19%), Positives = 245/547 (44%), Gaps = 49/547 (8%)

Query: 196  LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDI 255
            LQV+++  EE   K    E +LV + ++++  ++   ++     ++     Q+++     
Sbjct: 838  LQVSRQE-EEMMAK----EEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAE 892

Query: 256  AQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENL 315
             +L    +E    + + KQ LEE    L  +VE+   +CQ L+ EK+            +
Sbjct: 893  TELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKK-----------KM 941

Query: 316  NAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLF 375
               +Q L+++   E+  R+KLQ +++  ++ L++ +E    L  + C    ++ KEK L 
Sbjct: 942  QQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNC----KLAKEKKLL 997

Query: 376  EEELKQTLDELDKLQQK-------EEQAERLVKQLEEEAK---SRAEELKLLEEKLKGKE 425
            E+ + +    L + ++K       + + E ++  LEE  +    + +EL+    KL+G  
Sbjct: 998  EDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057

Query: 426  AELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFE---SYKALTASEIEDLKLENSSLQ 482
             +L    A        L+ +     + L+   A+ E   + K +   +I +L+ + S LQ
Sbjct: 1058 TDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQ 1117

Query: 483  E--KAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 540
            E  ++ +A +N  + Q + L  E    E ++  L+    S   + E++       Q++  
Sbjct: 1118 EDLESERASRNKAEKQKRDLGEE---LEALKTELEDTLDSTAAQQELRS---KREQEVNI 1171

Query: 541  LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA 600
            L+  L+++ +    Q+++    + +      EL E++ + + +   L    +  + +   
Sbjct: 1172 LKKTLEEEAKTHEAQIQE---MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGE 1228

Query: 601  FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR 660
               E + LL   G ++ +  K+     +L    N  ++++   +L D+ ++L+ E+  + 
Sbjct: 1229 LANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVR--TELADKVTKLQVELDNVT 1286

Query: 661  CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLK--EGNTNCYRAPM 718
              L++     +KL ++ +  L  +  D  +    E+++  +L T LK  E   N +R  +
Sbjct: 1287 GLLSQSDSKSSKLTKDFS-ALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQL 1345

Query: 719  ECQESWK 725
            E +E  K
Sbjct: 1346 EEEEEAK 1352



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 122/546 (22%), Positives = 251/546 (45%), Gaps = 86/546 (15%)

Query: 185  MMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEK--SETEKLLEYIE--- 239
            MMAK+E + +K++  Q + E    ++  L+ +L++ EK ++ E+  +ETE   E  E   
Sbjct: 847  MMAKEEEL-VKVREKQLAAENRLTEMETLQSQLMA-EKLQLQEQLQAETELCAEAEELRA 904

Query: 240  EISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK 299
             ++    ++E+   D+    E  +E+   + + K+ +++NI  L +Q+E+     Q L+ 
Sbjct: 905  RLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQL 964

Query: 300  EK-EDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSL- 357
            EK        +   E +  E QN K       +E++ L+ +  +  + L +E+E S SL 
Sbjct: 965  EKVTTEAKLKKLEEEQIILEDQNCKL-----AKEKKLLEDRIAEFTTNLTEEEEKSKSLA 1019

Query: 358  -----HQKLCSFQEEMVKEKNLFEEELKQTLDELD----------------------KLQ 390
                 H+ + +  EE ++ +    +EL++T  +L+                      +L 
Sbjct: 1020 KLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLA 1079

Query: 391  QKEEQAERLVKQLEEEAKSR---AEELKLLEEKLKGKEAELEKSSAAHTQATLL---LQE 444
            +KEE+ +  + ++EEEA  +    ++++ LE ++   + +LE   A+  +A      L E
Sbjct: 1080 KKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGE 1139

Query: 445  KYDSMVQSLEDV---TAQFESYKALTASEI--------EDLKLENSSLQEKAAKAGKNAE 493
            + +++   LED    TA  +  ++    E+        E+ K   + +QE   K  +  E
Sbjct: 1140 ELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVE 1199

Query: 494  DVQHQILATE--SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEED 551
            ++  Q+  T+   +N E  +  L+ +      E ++       LQ   D +++ K+ E  
Sbjct: 1200 ELAEQLEQTKRVKANLEKAKQTLENERGELANEVKV------LLQGKGDSEHKRKKVE-- 1251

Query: 552  FRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNE 611
               QL++ + +  E E    EL +++ K   L  EL N T      L   + +   L  +
Sbjct: 1252 --AQLQELQVKFNEGERVRTELADKVTK---LQVELDNVTG----LLSQSDSKSSKLTKD 1302

Query: 612  HGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSET 671
              A + QL   ++    LL  +N +QK+    KLK    Q++ E +  R QL ++++++ 
Sbjct: 1303 FSALESQLQDTQE----LLQEEN-RQKLSLSTKLK----QVEDEKNSFREQLEEEEEAKH 1353

Query: 672  KLQEEL 677
             L++++
Sbjct: 1354 NLEKQI 1359



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 110/589 (18%), Positives = 247/589 (41%), Gaps = 65/589 (11%)

Query: 9    KRFNDPSGCAPSPGAYDVKTLEVLKGPVSF--QKSQRFKQQKESKQNLNVDKDTTLPASA 66
            K+  D  GC  +      K  + L+G      +K   + + +++K  L  + D  L    
Sbjct: 1371 KKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLD 1430

Query: 67   RKVKSSESKKESQKNDKDLKILEKEIRV-LLQERGAQDRRIQDLETELEKMEARLNAALR 125
             + +S+ + ++ QK    L   EK I     +ER   +   ++ ET+   +   L  A+ 
Sbjct: 1431 HQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAME 1490

Query: 126  EKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGM 185
            +K  L   N     ++ +L  + + +     E   +K+ R L  ++ +++ + E     +
Sbjct: 1491 QKAELERLNKQFRTEMEDLMSSKDDVGKSVHEL--EKSKRALEQQVEEMKTQLEELEDEL 1548

Query: 186  MAKQEG---MEMKLQVTQRSLEES-QGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI 241
             A ++    +E+ LQ  +   E   QG+  Q E K   + ++  + ++E E   +  ++ 
Sbjct: 1549 QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELE---DERKQR 1605

Query: 242  SCASDQVEKYKLDIAQLEENLKEKN---DEILSLKQSLEENIVILSKQVEDLNV-KCQLL 297
            S A    +K ++D+  LE ++   N   DE +   + L+  +    ++++D    + ++L
Sbjct: 1606 SMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEIL 1665

Query: 298  EKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSL 357
             + KE     N +  +++ AEM  L+++    ++ + + QQ+  ++        E+++S 
Sbjct: 1666 AQAKE-----NEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELAD------EIANSS 1714

Query: 358  HQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLL 417
             +   + +E     K   E  + Q  +EL++ Q   E     +K+   +      +L L 
Sbjct: 1715 GKGALALEE-----KRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLE 1769

Query: 418  EEKLKGKEAELEKSSAAHTQATLLLQE-------KYDSMVQSLEDVTAQFESYKALTASE 470
                +  E   ++    + +  + LQE       KY + + +LE   AQ E        +
Sbjct: 1770 RSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLE-------EQ 1822

Query: 471  IEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEI 530
            +++   E  +  ++  +  K  +DV  Q+     + ++Y             K+   K  
Sbjct: 1823 LDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQY-------------KDQADKAS 1869

Query: 531  TVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK 579
            T     ++  L+ QL++ EE+ ++        + E E+ T E  + +N+
Sbjct: 1870 T-----RLKQLKRQLEEAEEEAQRANASRRKLQRELEDAT-ETADAMNR 1912



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 85/465 (18%), Positives = 203/465 (43%), Gaps = 82/465 (17%)

Query: 41   SQRFKQQKESKQNLNVDKDTTLPASARKVKSS-ESKKESQKNDKDLKI-----------L 88
            S ++ ++++  +    +K+T   + AR ++ + E K E ++ +K  +            +
Sbjct: 1457 SAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDV 1516

Query: 89   EKEIRVLLQERGAQDRRIQDLETELEKMEARLNAA----LREKTSLSANNATLEKQLI-- 142
             K +  L + + A ++++++++T+LE++E  L A     LR + +L A  A  E+ L   
Sbjct: 1517 GKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGR 1576

Query: 143  ---------ELTRTNELLKSKFSENGNQKNLRILSL----------------------EL 171
                     +L R    ++++  +   Q+++ + +                       E 
Sbjct: 1577 DEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEA 1636

Query: 172  MKLRNKRETKMRGMM-------AKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEK 224
            +K   K + +M+  M       A +E +  + +  ++ L+  + ++ QL+ +L + E+ K
Sbjct: 1637 IKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAK 1696

Query: 225  IDEKSETEKLLEYIEEIS----CASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENI 280
               + E ++L + I   S     A ++  + +  IAQLEE L+E+      +   L++  
Sbjct: 1697 RQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKAN 1756

Query: 281  VILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNL----KQKFI--------- 327
            + + +   DLN++    +K +       R+ N+ L  ++Q +    K K+          
Sbjct: 1757 LQIDQINTDLNLERSHAQKNENARQQLERQ-NKELKVKLQEMEGTVKSKYKASITALEAK 1815

Query: 328  ---LEQQEREKLQQKELQIDSLLQQEKELSSSLHQ-----KLCSFQEEMVKEKNLFEEEL 379
               LE+Q   + ++++     + + EK+L   L Q     +     ++   + +   ++L
Sbjct: 1816 IAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQL 1875

Query: 380  KQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGK 424
            K+ L+E ++  Q+   + R +++  E+A   A+ +      LK K
Sbjct: 1876 KRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNK 1920


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score =  119 bits (298), Expect = 1e-26
 Identities = 126/549 (22%), Positives = 257/549 (46%), Gaps = 56/549 (10%)

Query: 172  MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKID--- 226
            MKL  K +  ++    ++E   MK   Q T+  L +S+ K  +LE KLV++ +EK D   
Sbjct: 831  MKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQL 890

Query: 227  -EKSETEKLL---EYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVI 282
              ++E+E LL   E  +++  A  Q+E    ++ +  E+ +E N E+ + K+ LE+    
Sbjct: 891  QVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 950

Query: 283  LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQ 342
            L K ++DL +    +EKEK  H   N+   +NL  E+  L +      +E++ LQ+   Q
Sbjct: 951  LKKDIDDLELTLAKVEKEK--HATENKV--KNLTEELSGLDETIAKLTREKKALQEAHQQ 1006

Query: 343  IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQ 402
                LQ E++  +SL++     ++++   ++  E+E K  +D    L++ + + E  +K 
Sbjct: 1007 ALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVD----LERNKRKLEGDLKL 1062

Query: 403  LEEEAKSRAEELKLLEEKLKGKEAE-LEKSSAAHTQATLLLQ-----EKYDSMVQSLEDV 456
             +E       + + L+E+LK K+ E  +  S    + TL LQ     ++  + ++ LE+ 
Sbjct: 1063 AQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEE 1122

Query: 457  TAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDL 516
                 + +A T  +  D   E   L E+  +AG        QI   +    E++++  DL
Sbjct: 1123 IEAERATRAKTEKQRSDYARELEELSERLEEAGGVTST---QIELNKKREAEFLKLRRDL 1179

Query: 517  QTKSALKETEIKEITVSFLQKITDLQNQ----------LKQQEEDFRKQLEDEEG----- 561
            +  +   E  +  +       + +L  Q          L++++ +F+ +++D        
Sbjct: 1180 EEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESV 1239

Query: 562  --RKAEKENTTAELTEEINKWRLLYEELYNK-----TKPFQLQLDAFEVEKQALLNEHGA 614
               KA  E     L +++++ R   EE+        T+  +LQ +A E+ +Q  L E  +
Sbjct: 1240 SKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQ--LEEKES 1297

Query: 615  AQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL----KSEVSKLRCQLAKKKQSE 670
               QL++ + ++ +    + LK++++   K K+  +      + +   LR Q  ++++ +
Sbjct: 1298 IVSQLSRSKQAFTQQT--EELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGK 1355

Query: 671  TKLQEELNK 679
             +LQ  L+K
Sbjct: 1356 AELQRALSK 1364



 Score =  110 bits (276), Expect = 4e-24
 Identities = 158/717 (22%), Positives = 321/717 (44%), Gaps = 82/717 (11%)

Query: 42   QRFKQQKESKQN---LNVDKDTTLPASARKVKSSESKKESQKNDK--DLKILEKEIRVLL 96
            QR KQ+ E +++   L +D  ++   S  K K++  K      D+  + +   +EI+  L
Sbjct: 1212 QRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSL 1271

Query: 97   QERGAQDRRIQ----DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN---- 148
             E   Q  R+Q    +L  +LE+ E+ ++   R K + +     L++QL E  +      
Sbjct: 1272 SELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALA 1331

Query: 149  ----------ELLKSKFSENGN-----QKNLRILSLELMKLRNKRETKMRGMMAKQEGME 193
                      +LL+ ++ E        Q+ L   + E+ + R K ET    +   +E  E
Sbjct: 1332 HALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETD--AIQRTEELEE 1389

Query: 194  MKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 253
             K ++ QR L++S+ ++  +  K  S+EK K   + E E L+  +E  +  +  ++K + 
Sbjct: 1390 AKKKLAQR-LQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQR 1448

Query: 254  DIAQLEENLKEKNDEILS-LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHN 312
            +  ++    K K +E  + L+ SL+E     S+ +     K +   +E  D +   +  N
Sbjct: 1449 NFDKVLAEWKTKCEESQAELEASLKE-----SRSLSTELFKLKNAYEEALDQLETVKREN 1503

Query: 313  ENLNAEMQNLKQ------KFILE-QQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQ 365
            +NL  E+ +L +      K I E ++ R++++ ++  I   L++ +        K+   Q
Sbjct: 1504 KNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQ 1563

Query: 366  EEMVKEKNLFEEELKQTLDELDKLQQKEEQA-ERLVKQLEEEAKSRAEELKLLEEKLKGK 424
             E+ + K+  + ++ +  +E+++L++  ++  E +   L+ E +SR E ++L ++K++G 
Sbjct: 1564 LELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRL-KKKMEGD 1622

Query: 425  EAELE-KSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQE 483
              E+E + S A+ QA   L+    S+   L+D     +   AL   E  DLK + + ++ 
Sbjct: 1623 LNEIEIQLSHANRQAAETLKH-LRSVQGQLKDTQLHLDD--ALRGQE--DLKEQLAIVER 1677

Query: 484  KAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQN 543
            +A       E+++  +  TE + +   + LLD   +  L  T+   +  +  +  TDL  
Sbjct: 1678 RANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLM- 1736

Query: 544  QLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK-------WRLLYEELYNKTKPFQL 596
            QL+ + ED  +   + E +  +     A + EE+ K          + + L    K  Q 
Sbjct: 1737 QLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQH 1796

Query: 597  QLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQ-----------NLKQKIKHVVKL 645
            +LD  E E+ AL       Q+   +IR+   +L G Q             ++++K +   
Sbjct: 1797 RLD--EAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQ 1854

Query: 646  KDENS----QLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKE 698
             +E+     +L+  V KL+ ++   K+   +  E+ N      H    +   HE +E
Sbjct: 1855 SEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQAN-----AHLTKFRKAQHELEE 1906



 Score =  103 bits (256), Expect = 7e-22
 Identities = 131/691 (18%), Positives = 308/691 (44%), Gaps = 73/691 (10%)

Query: 47   QKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKI---LEKEIRVLLQERGAQD 103
            Q ES+  L+ ++       A+    ++ K+ +++ + + +I   L  + R L  E     
Sbjct: 893  QAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK 952

Query: 104  RRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKN 163
            + I DLE  L K+E   +A   +  +L+   + L++ + +LTR  + L     +  +Q+ 
Sbjct: 953  KDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKAL-----QEAHQQA 1007

Query: 164  LRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKE 223
            L  L  E  K+ +  +TK + +  + E +E  L+  ++   + +    +LEG L   ++ 
Sbjct: 1008 LDDLQAEEDKVNSLNKTKSK-LEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQES 1066

Query: 224  KIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEE---NI 280
             +D +++ ++L           ++++K   +  QL+  ++++    L  ++ ++E    I
Sbjct: 1067 ILDLENDKQQL----------DERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARI 1116

Query: 281  VILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENL---------NAEMQNLKQ-KFI-LE 329
              L +++E         EK++ D+     E +E L           E+   ++ +F+ L 
Sbjct: 1117 EELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLR 1176

Query: 330  QQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQ---EEMVKEKNLFEEELKQTLDEL 386
            +   E   Q E  + +L ++  +  + L +++ + Q   +++ KEK+ F+ E+      +
Sbjct: 1177 RDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSM 1236

Query: 387  DKLQQKEEQAERLVKQLEE---EAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQ 443
            + + + +   E++ + LE+   EA+ + EE++    +L  +++ L+  +    + +  L+
Sbjct: 1237 ESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAG---ELSRQLE 1293

Query: 444  EKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATE 503
            EK +S+V  L      F         ++E+     ++L      +  + + ++ Q    +
Sbjct: 1294 EK-ESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQ 1352

Query: 504  SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRK 563
                E  R L    ++ A   T+ +   +   +++ + + +L Q+ +D  +Q+E    + 
Sbjct: 1353 EGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKC 1412

Query: 564  AEKENT-------TAELTEEINKWRLLYEELYNKTKPF-------QLQLDAFEVEKQALL 609
            A  E T         +L  ++ +   L   L  K + F       + + +  + E +A L
Sbjct: 1413 ASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASL 1472

Query: 610  NEHGAAQEQLNKIRDSYAKLLG--------HQNLKQKIKHVVKLKDENSQLKSEVSKLRC 661
             E  +   +L K++++Y + L         ++NL+Q+I  + +   EN +   E+ K R 
Sbjct: 1473 KESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRK 1532

Query: 662  QLAKKK--------QSETKLQEELNKVLGIK 684
            Q+  +K        ++E  L+ E  K+L I+
Sbjct: 1533 QIELEKADIQLALEEAEAALEHEEAKILRIQ 1563



 Score =  100 bits (250), Expect = 4e-21
 Identities = 162/774 (20%), Positives = 324/774 (41%), Gaps = 106/774 (13%)

Query: 25   DVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKD 84
            D+  LE+    V  +K     + K   + L+   D T+    R+ K+ +   +   +D  
Sbjct: 954  DIDDLELTLAKVEKEKHATENKVKNLTEELS-GLDETIAKLTREKKALQEAHQQALDD-- 1010

Query: 85   LKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAAL-REKTSLSANNATLEKQLIE 143
            L+  E ++  L + +   +++++DLE+ LE+ E +L   L R K  L  +    ++ +++
Sbjct: 1011 LQAEEDKVNSLNKTKSKLEQQVEDLESSLEQ-EKKLRVDLERNKRKLEGDLKLAQESILD 1069

Query: 144  LTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSL 203
            L    + L  +  +            E  +L++K E +    +  Q+    K++  Q  +
Sbjct: 1070 LENDKQQLDERLKKK---------DFEYCQLQSKVEDEQTLGLQFQK----KIKELQARI 1116

Query: 204  EESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEIS-CASDQVEKYKLDIAQ----- 257
            EE + +I          EK++ D   E E+L E +EE     S Q+E  K   A+     
Sbjct: 1117 EELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLR 1176

Query: 258  --LEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK-------------- 301
              LEE   +    + +L++   +++  L +Q+++L    Q LEKEK              
Sbjct: 1177 RDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSM 1236

Query: 302  -----------------EDHVNRNREHNENLNAEMQNLK-QKFILEQQERE---KLQQKE 340
                             ED ++  R  NE +   +  L  QK  L+ +  E   +L++KE
Sbjct: 1237 ESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKE 1296

Query: 341  LQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLV 400
              I S L + K+  +   ++L    EE  K KN     L+ +  + D L+++ E+ +   
Sbjct: 1297 -SIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGK 1355

Query: 401  KQL------------------EEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLL 442
             +L                  E +A  R EEL+  ++KL  +  + E+   A       L
Sbjct: 1356 AELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASL 1415

Query: 443  QEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILAT 502
            ++    +   +ED+    E   +L A+  +  +  +  L E   K  ++  +++  +  +
Sbjct: 1416 EKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKES 1475

Query: 503  ESSNQEYVRMLLDLQTKSALKETE-IKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEG 561
             S + E  +  L    + AL + E +K    +  Q+I DL  Q+ +  +      E E+ 
Sbjct: 1476 RSLSTELFK--LKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIH---ELEKS 1530

Query: 562  RK-AEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLN 620
            RK  E E    +L  E  +  L +EE     K  ++QL+  +V K  +  +     E++ 
Sbjct: 1531 RKQIELEKADIQLALEEAEAALEHEE----AKILRIQLELTQV-KSEIDRKIAEKDEEIE 1585

Query: 621  KIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLK----SEVSKLRCQLAKKKQSETKLQEE 676
            +++ +Y + +  + ++  +   V+ ++E  +LK     +++++  QL+   +   +  + 
Sbjct: 1586 QLKRNYQRTV--ETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKH 1643

Query: 677  LNKVLG-IK----HFDPSKAFHHESKENFAL---KTPLKEGNTNCYRAPMECQE 722
            L  V G +K    H D +     + KE  A+   +  L +      RA +E  E
Sbjct: 1644 LRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTE 1697



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 106/505 (20%), Positives = 219/505 (43%), Gaps = 65/505 (12%)

Query: 46   QQKESKQNLNVDKDTTLPASARKVKSS--ESKKESQKNDKDLKILEKEIRVLLQERGAQD 103
            ++ +++   ++ +  +L     K+K++  E+  + +   ++ K LE+EI  L ++     
Sbjct: 1462 EESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENG 1521

Query: 104  RRIQDLETELEKME---ARLNAALRE-KTSLSANNATLEKQLIELTRTNELLKSKFSENG 159
            + I +LE   +++E   A +  AL E + +L    A + +  +ELT+    +  K +E  
Sbjct: 1522 KTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKD 1581

Query: 160  NQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVS 219
             +       +E +K RN + T         E M+  L    RS  E+     ++EG L  
Sbjct: 1582 EE-------IEQLK-RNYQRTV--------ETMQSALDAEVRSRNEAIRLKKKMEGDLNE 1625

Query: 220  IEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEEN 279
            IE +      +  + L+++  +       + +  D  + +E+LKE+    L++   +E  
Sbjct: 1626 IEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQ----LAI---VERR 1678

Query: 280  IVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK 339
              +L  +VE+L    +  E+ ++                   L ++ +L+  ER  +Q  
Sbjct: 1679 ANLLQAEVEELRATLEQTERARK-------------------LAEQELLDSNER--VQLL 1717

Query: 340  ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL-------DELDKLQQK 392
              Q  SL+  +K+L + L Q L S  E+  ++    EE+ K+ +       +EL K Q  
Sbjct: 1718 HTQNTSLIHTKKKLETDLMQ-LQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDT 1776

Query: 393  EEQAERLVKQLEEEAKSRAEELKLLEE-KLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 451
                ER+ K LE+  K     L   E+  LKG + +++K      +    L+ +     +
Sbjct: 1777 SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTE 1836

Query: 452  SLEDVTAQFESYKALTASEIED----LKLEN--SSLQEKAAKAGKNAEDVQHQILATESS 505
            S++ +       K LT    ED    L+L++    LQ K     + AE+   Q  A  + 
Sbjct: 1837 SVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTK 1896

Query: 506  NQEYVRMLLDLQTKSALKETEIKEI 530
             ++    L + + ++ + E+++ ++
Sbjct: 1897 FRKAQHELEEAEERADIAESQVNKL 1921



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 85/444 (19%), Positives = 191/444 (43%), Gaps = 76/444 (17%)

Query: 51   KQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGA----QDRRI 106
            ++N N++++     + +  ++ ++  E +K+ K +++ + +I++ L+E  A    ++ +I
Sbjct: 1501 RENKNLEQEIA-DLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKI 1559

Query: 107  QDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRI 166
              ++ EL ++++ ++  + EK      +  +E+      RT E ++S        +N   
Sbjct: 1560 LRIQLELTQVKSEIDRKIAEK------DEEIEQLKRNYQRTVETMQSALDAEVRSRN--- 1610

Query: 167  LSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQ-------------- 212
               E ++L+ K E  +  +  +      +   T + L   QG++                
Sbjct: 1611 ---EAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQED 1667

Query: 213  LEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSL 272
            L+ +L  +E+     ++E E+L   +E+   A    E+  LD  +  + L  +N  ++  
Sbjct: 1668 LKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHT 1727

Query: 273  KQSLEENIVILSKQVEDLNVKCQLLEKEKE----------DHVNRNREHNENLNAEMQNL 322
            K+ LE +++ L  +VED +   +  E++ +          + + + ++ + +L    +NL
Sbjct: 1728 KKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL 1787

Query: 323  KQ-----KFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQ---------KLCSFQEEM 368
            +Q     +  L++ E+  L+  + QI  L  + +EL   L           K     E  
Sbjct: 1788 EQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERR 1847

Query: 369  VKEKNLFEEELKQTL----DELDKLQQKEEQAERLVKQLEE-----------------EA 407
            VKE     EE ++ +    D +DKLQ K +  +R  ++ +E                 EA
Sbjct: 1848 VKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEA 1907

Query: 408  KSRAEELKLLEEKLKGKEAELEKS 431
            + RA+  +    KL+ K  +   S
Sbjct: 1908 EERADIAESQVNKLRAKTRDFTSS 1931


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score =  117 bits (293), Expect = 4e-26
 Identities = 121/546 (22%), Positives = 248/546 (45%), Gaps = 50/546 (9%)

Query: 172  MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 229
            MKL  K +  ++    ++E   MK   + T+  L +++ K  +LE K+V++ +EK D + 
Sbjct: 834  MKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQL 893

Query: 230  ETEKLLEYIEEISCASDQVEKYKL-------DIAQLEENLKEKNDEILSLKQSLEENIVI 282
            + +   + + +     DQ+ K K+       ++ +  E+ +E N E+ + K+ LE+    
Sbjct: 894  QVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 953

Query: 283  LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQ 342
            L K ++DL +    +EKEK  H   N+   +NL  EM  L +      +E++ LQ+   Q
Sbjct: 954  LKKDIDDLELTLAKVEKEK--HATENKV--KNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1009

Query: 343  IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQ 402
                LQ E++  ++L +     ++++   +   E+E K  +D    L++ + + E  +K 
Sbjct: 1010 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMD----LERAKRKLEGDLKL 1065

Query: 403  LEEEAKSRAEELKLLEEKLKGKEAELE--KSSAAHTQAT-LLLQEKYDSMVQSLEDVTAQ 459
             +E       + + L+EKLK KE E+   +S     QA  + LQ+K   +   +E++  +
Sbjct: 1066 AQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEE 1125

Query: 460  FESYKALTA---SEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDL 516
             E+ +A  A    +  DL  E   + E+  +AG        QI   +    E+ +M  DL
Sbjct: 1126 IEAERASRAKAEKQRSDLSRELEEISERLEEAG---GATSAQIEMNKKREAEFQKMRRDL 1182

Query: 517  QTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEE 576
            +  +   E     +       + +L  Q+   +   +++LE E+     + +  A   E 
Sbjct: 1183 EEATLQHEATAATLRKKHADSVAELGEQIDNLQR-VKQKLEKEKSEMKMEIDDLASNMET 1241

Query: 577  INKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLL------ 630
            ++K +   E++    +    ++   E E+Q L+N+  A + +L      Y++ L      
Sbjct: 1242 VSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTL 1301

Query: 631  ------GHQNLKQKIKHVVKLKDENSQLKSEVSK-----------LRCQLAKKKQSETKL 673
                  G Q   Q+I+ + +  +E  + KS ++            LR Q  ++++++ +L
Sbjct: 1302 VSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAEL 1361

Query: 674  QEELNK 679
            Q  ++K
Sbjct: 1362 QRAMSK 1367



 Score =  111 bits (277), Expect = 3e-24
 Identities = 138/693 (19%), Positives = 306/693 (44%), Gaps = 85/693 (12%)

Query: 45   KQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDR 104
            +Q+K+ + +L   K   L    +  + S    E+ K   D K+ +KE  +   +   +D 
Sbjct: 1043 EQEKKIRMDLERAK-RKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDE 1101

Query: 105  RI--QDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQK 162
            +     L+ ++++++AR+     E  +  A+ A  EKQ  +L+R  E +  +  E G   
Sbjct: 1102 QALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT 1161

Query: 163  NLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG-KIAQLEGKLVSIE 221
            + +I      ++  KRE + + M    E   ++ + T  +L +     +A+L  ++ +++
Sbjct: 1162 SAQI------EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQ 1215

Query: 222  KEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIV 281
            + K   + E  ++   I++++   + V K K     LE+  +   D++  +K   EE   
Sbjct: 1216 RVKQKLEKEKSEMKMEIDDLASNMETVSKAK---GNLEKMCRALEDQLSEIKTKEEEQ-- 1270

Query: 282  ILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKEL 341
               + + DL  +   L+ E  ++ +R  +  + L +++   KQ F  + +E ++  ++E+
Sbjct: 1271 --QRLINDLTAQRARLQTESGEY-SRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEI 1327

Query: 342  QIDSLL------------------QQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL 383
            +  S L                  ++E+E  + L + +     E+ + +  +E +  Q  
Sbjct: 1328 KAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRT 1387

Query: 384  DELD----KLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQAT 439
            +EL+    KL Q+ + AE  V+ +  +  S  +  + L+ +++    ++E+++AA     
Sbjct: 1388 EELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACA--- 1444

Query: 440  LLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI 499
                   D   ++ + + A+++     T +E+E  + E+ SL  +  K     E+   Q+
Sbjct: 1445 -----ALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQL 1499

Query: 500  LATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDE 559
               +  N+   + + DL  + A     I E+     +++   +++L+   E+    LE E
Sbjct: 1500 ETLKRENKNLQQEISDLTEQIAEGGKRIHELE-KIKKQVEQEKSELQAALEEAEASLEHE 1558

Query: 560  EGR-----------KAEKENTTAELTEEINKWR------------LLYEELYNKTKPFQL 596
            EG+           K+E +   AE  EEI++ +             L  E+ ++    +L
Sbjct: 1559 EGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRL 1618

Query: 597  QL----DAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQ-NLKQKIKHVVKLKDENSQ 651
            +     D  E+E Q L + +  A E L   R++ A L   Q +L   ++    LK++ + 
Sbjct: 1619 KKKMEGDLNEMEIQ-LNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAM 1677

Query: 652  -------LKSEVSKLRCQLAKKKQSETKLQEEL 677
                   L++E+ +LR  L + ++S    ++EL
Sbjct: 1678 VERRANLLQAEIEELRATLEQTERSRKIAEQEL 1710



 Score =  106 bits (264), Expect = 9e-23
 Identities = 145/720 (20%), Positives = 313/720 (43%), Gaps = 113/720 (15%)

Query: 68   KVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREK 127
            K +  ++K+E  K +   K LE+++  L+QE+     ++Q     L   E R +  ++ K
Sbjct: 857  KEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTK 916

Query: 128  TSLSA------NNATLEKQL-IELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKR-- 178
              L A        A  E+++  ELT     L+ + SE   +K++  L L L K+  ++  
Sbjct: 917  IQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE--LKKDIDDLELTLAKVEKEKHA 974

Query: 179  -ETKMRGMMAKQEGME---MKLQVTQRSLEESQGK----IAQLEGKLVSIEKEKIDEKSE 230
             E K++ +  +  G++    KL   +++L+E+  +    +   E K+ ++ K KI  + +
Sbjct: 975  TENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQ 1034

Query: 231  TEKLLEYIE------------------EISCASDQVEKYKLDIAQLEENLKEKNDEILSL 272
             + L   +E                  ++  A +     + D  QL+E LK+K  E+  L
Sbjct: 1035 VDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGL 1094

Query: 273  KQSLEENIVI---LSKQVEDLNVKCQLLEKEKE-DHVNRNR--EHNENLNAEMQNLKQKF 326
            +  +E+   +   L K++++L  + + LE+E E +  +R +  +   +L+ E++ + ++ 
Sbjct: 1095 QSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL 1154

Query: 327  ------ILEQQEREKLQQKELQ-----IDSLLQQEKELSSSLHQK--------------L 361
                     Q E  K ++ E Q     ++    Q +  +++L +K              L
Sbjct: 1155 EEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNL 1214

Query: 362  CSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEE---EAKSRAEELKLLE 418
               ++++ KEK+  + E+      ++ + + +   E++ + LE+   E K++ EE + L 
Sbjct: 1215 QRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLI 1274

Query: 419  EKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSL----EDVTAQFESYKALTASEIEDL 474
              L  + A L+  S  +++    L EK D++V  L    +  T Q E  K     EI+  
Sbjct: 1275 NDLTAQRARLQTESGEYSRQ---LDEK-DTLVSQLSRGKQAFTQQIEELKRQLEEEIK-- 1328

Query: 475  KLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSF 534
                S+L      +  + + ++ Q    + +  E  R +    ++ A   T+ +   +  
Sbjct: 1329 --AKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQR 1386

Query: 535  LQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEE-------L 587
             +++ + + +L Q+ +D  + +E    + A  E T   L  E+    +  E        L
Sbjct: 1387 TEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAAL 1446

Query: 588  YNKTKPF-------QLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG--------H 632
              K + F       + + +    E +A   E  +   +L KI+++Y + L         +
Sbjct: 1447 DKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKREN 1506

Query: 633  QNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKK--------QSETKLQEELNKVLGIK 684
            +NL+Q+I  + +   E  +   E+ K++ Q+ ++K        ++E  L+ E  K+L I+
Sbjct: 1507 KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQ 1566



 Score =  104 bits (259), Expect = 3e-22
 Identities = 146/688 (21%), Positives = 315/688 (45%), Gaps = 76/688 (11%)

Query: 42   QRFKQQKE---SKQNLNVDKDTTLPASARKVKSSESKKESQKNDK--DLKILEKEIRVLL 96
            QR KQ+ E   S+  + +D   +   +  K K +  K      D+  ++K  E+E + L+
Sbjct: 1215 QRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLI 1274

Query: 97   QERGAQDRRIQ----DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN---- 148
             +  AQ  R+Q    +   +L++ +  ++   R K + +     L++QL E  +      
Sbjct: 1275 NDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALA 1334

Query: 149  ----------ELLKSKFSENGN-----QKNLRILSLELMKLRNKRETKMRGMMAKQEGME 193
                      +LL+ ++ E        Q+ +   + E+ + R K ET    +   +E  E
Sbjct: 1335 HALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETD--AIQRTEELEE 1392

Query: 194  MKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 253
             K ++ QR L++++  +  +  K  S+EK K   ++E E L+  +E  + A   ++K + 
Sbjct: 1393 AKKKLAQR-LQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQR 1451

Query: 254  DIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNE 313
            +  ++    K+K +E  +  ++ ++    LS ++     K +   +E  D +   +  N+
Sbjct: 1452 NFDKILAEWKQKCEETHAELEASQKESRSLSTEL----FKIKNAYEESLDQLETLKRENK 1507

Query: 314  NLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKN 373
            NL  E+ +L ++     +   +L++ + Q++   Q++ EL ++L +   S + E  K   
Sbjct: 1508 NLQQEISDLTEQIAEGGKRIHELEKIKKQVE---QEKSELQAALEEAEASLEHEEGKILR 1564

Query: 374  LFEEELKQTLDELD-KLQQKEEQAERLVKQ-----------LEEEAKSRAEELKLLEEKL 421
            + + EL Q   E+D K+ +K+E+ +++ +            L+ E +SR + ++L ++K+
Sbjct: 1565 I-QLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRL-KKKM 1622

Query: 422  KG--KEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENS 479
            +G   E E++ + A    A  L    Y +    L+D     +   AL + E  DLK + +
Sbjct: 1623 EGDLNEMEIQLNHANRMAAEAL--RNYRNTQAILKDTQLHLDD--ALRSQE--DLKEQLA 1676

Query: 480  SLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKIT 539
             ++ +A       E+++  +  TE S +   + LLD   +  L  T+   +  +  +  T
Sbjct: 1677 MVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLET 1736

Query: 540  DLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK-------WRLLYEELYNKTK 592
            D+ +Q++ + ED  ++  + E +  +     A + EE+ K          + + L    K
Sbjct: 1737 DI-SQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK 1795

Query: 593  PFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL 652
              Q +LD  E E+ AL       ++Q+ K+     +L G    +QK ++V  +K      
Sbjct: 1796 DLQHRLD--EAEQLAL----KGGKKQIQKLEARVRELEGEVESEQK-RNVEAVKGLRKH- 1847

Query: 653  KSEVSKLRCQLAKKKQSETKLQEELNKV 680
            + +V +L  Q  + +++  +LQ+ ++K+
Sbjct: 1848 ERKVKELTYQTEEDRKNILRLQDLVDKL 1875



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 95/435 (21%), Positives = 193/435 (44%), Gaps = 54/435 (12%)

Query: 22   GAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTL--PASARKVKSSESKKESQ 79
            G   +  LE +K  V  +KS+     +E++ +L  ++   L       +VKS   +K ++
Sbjct: 1523 GGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAE 1582

Query: 80   KNDKDLKILEKEIRVLLQERGAQDRRIQD----------LETELEKMEARLN-------A 122
            K+++  ++    IR++   +   D  I+           +E +L +ME +LN        
Sbjct: 1583 KDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAE 1642

Query: 123  ALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRE-TK 181
            ALR   +  A     +  L +  R+ E LK + +    + NL  L  E+ +LR   E T+
Sbjct: 1643 ALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANL--LQAEIEELRATLEQTE 1700

Query: 182  MRGMMAKQEGMEMKLQV------------TQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 229
                +A+QE ++   +V            T++ LE     I+Q++G++  I +E    ++
Sbjct: 1701 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD---ISQIQGEMEDIIQEA---RN 1754

Query: 230  ETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVIL----SK 285
              EK  + I + +  +++++K +   A LE   K     +  L+  L+E   +      K
Sbjct: 1755 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKK 1814

Query: 286  QVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDS 345
            Q++ L  + + LE E E    RN E  + L    + +K+     +++R+ + + +  +D 
Sbjct: 1815 QIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDK 1874

Query: 346  LLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEE 405
            L  + K              EE  ++ N+   + ++   EL++ +++ + AE  V +L  
Sbjct: 1875 LQAKVKSYKRQ--------AEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKL-- 1924

Query: 406  EAKSRAEELKLLEEK 420
              KSR    K++ E+
Sbjct: 1925 RVKSREVHTKIISEE 1939



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 107/497 (21%), Positives = 210/497 (42%), Gaps = 73/497 (14%)

Query: 39   QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSS--ESKKESQKNDKDLKILEKEIRVLL 96
            QK +    + E+ Q     +  +L     K+K++  ES  + +   ++ K L++EI  L 
Sbjct: 1462 QKCEETHAELEASQK----ESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLT 1517

Query: 97   QERGAQDRRIQDLET---ELEKMEARLNAALRE-KTSLSANNATLEKQLIELTRTNELLK 152
            ++     +RI +LE    ++E+ ++ L AAL E + SL      + +  +EL +    + 
Sbjct: 1518 EQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVD 1577

Query: 153  SKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQ 212
             K +E   +       ++ MK  + R           E M+  L    RS  ++     +
Sbjct: 1578 RKIAEKDEE-------IDQMKRNHIRIV---------ESMQSTLDAEIRSRNDAIRLKKK 1621

Query: 213  LEGKLVSIE----------KEKIDEKSETEKLLEYIE-EISCASDQVEKYKLDIAQLEEN 261
            +EG L  +E           E +     T+ +L+  +  +  A    E  K  +A +E  
Sbjct: 1622 MEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERR 1681

Query: 262  LKEKNDEILSLKQSLEE---NIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLN-- 316
                  EI  L+ +LE+   +  I  +++ D + + QLL  +    +N  ++   +++  
Sbjct: 1682 ANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQI 1741

Query: 317  -AEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLF 375
              EM+++ Q+    +++ +K       +   L++E++ S+ L        E M K     
Sbjct: 1742 QGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHL--------ERMKKNLEQT 1793

Query: 376  EEELKQTLDELDKL---------QQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEA 426
             ++L+  LDE ++L         Q+ E +   L  ++E E K   E +K L  K + K  
Sbjct: 1794 VKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGL-RKHERKVK 1852

Query: 427  ELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS----LQ 482
            EL   +    +  L LQ+  D +        A+ +SYK   A E E+    N S    +Q
Sbjct: 1853 ELTYQTEEDRKNILRLQDLVDKL-------QAKVKSYKR-QAEEAEEQSNVNLSKFRRIQ 1904

Query: 483  EKAAKAGKNAEDVQHQI 499
             +  +A + A+  + Q+
Sbjct: 1905 HELEEAEERADIAESQV 1921



 Score = 33.1 bits (74), Expect = 0.93
 Identities = 39/166 (23%), Positives = 71/166 (42%), Gaps = 36/166 (21%)

Query: 535 LQKITDLQNQLKQQEEDFRKQLED---EEGRKAEKENTTAELTEEINKWRLLY------- 584
           L K  + + ++   +E+F K  E+    E ++ E E     L +E N  +L         
Sbjct: 843 LLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSL 902

Query: 585 ---EELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKH 641
              EE  ++    ++QL+A    K   + E    +E++N      A+L   +        
Sbjct: 903 ADAEERCDQLIKTKIQLEA----KIKEVTERAEDEEEIN------AELTAKKR------- 945

Query: 642 VVKLKDENSQLKSEVSKLRCQLAK----KKQSETKLQEELNKVLGI 683
             KL+DE S+LK ++  L   LAK    K  +E K++    ++ G+
Sbjct: 946 --KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL 989


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score =  117 bits (292), Expect = 5e-26
 Identities = 133/551 (24%), Positives = 259/551 (47%), Gaps = 60/551 (10%)

Query: 172  MKLRNKRETKMRGMMAKQEGMEMKLQVTQ--RSLEESQGKIAQLEGKLVSIEKEKIDEKS 229
            MKL  K +  ++    ++E   MK + T+   +LE+S+ +  +LE K+VS+ +EK D + 
Sbjct: 830  MKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQL 889

Query: 230  ETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKND----------EILSLKQSLEEN 279
            + +   + + +     DQ+ K K+   QLE  +KE N+          E+ + K+ LE+ 
Sbjct: 890  QVQAEQDNLADAEERCDQLIKNKI---QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE 946

Query: 280  IVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK 339
               L + ++DL +    +EKEK    N+ +    NL  EM  L +      +E++ LQ+ 
Sbjct: 947  CSELKRDIDDLELTLAKVEKEKHATENKVK----NLTEEMAGLDEIIAKLTKEKKALQEA 1002

Query: 340  ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL 399
              Q    LQ E++  ++L +     ++++   +   E+E K  +D    L++ + + E  
Sbjct: 1003 HQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMD----LERAKRKLEGD 1058

Query: 400  VKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLL---LQEKYDSMVQSLEDV 456
            +K  +E       + + L+E+LK K+ EL   +A       L   LQ+K   +   +E++
Sbjct: 1059 LKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEEL 1118

Query: 457  TAQFESYKALTASEIE----DLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRM 512
              + E+ +   A ++E    DL  E   + E+  +AG  A  V  QI   +    E+ +M
Sbjct: 1119 EEELEAERTARA-KVEKLRSDLSRELEEISERLEEAG-GATSV--QIEMNKKREAEFQKM 1174

Query: 513  LLDLQ--------TKSALKETEIKEITVSFLQKITDLQ---NQLKQQEEDFRKQLEDEEG 561
              DL+        T +AL++     +     ++I +LQ    +L++++ +F+ +L+D   
Sbjct: 1175 RRDLEEATLQHEATAAALRKKHADSV-AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTS 1233

Query: 562  R-------KAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQAL---LNE 611
                    KA  E     L +++N+ R   EE          Q    + E   L   L+E
Sbjct: 1234 NMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDE 1293

Query: 612  HGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKK-QSE 670
              A   QL + + +Y + L  ++LK++++  VK K+  +    + ++  C L +++ + E
Sbjct: 1294 KEALISQLTRGKLTYTQQL--EDLKRQLEEEVKAKNALAH-ALQSARHDCDLLREQYEEE 1350

Query: 671  TKLQEELNKVL 681
            T+ + EL +VL
Sbjct: 1351 TEAKAELQRVL 1361



 Score =  107 bits (267), Expect = 4e-23
 Identities = 155/723 (21%), Positives = 300/723 (41%), Gaps = 102/723 (14%)

Query: 40   KSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQER 99
            K Q   + KE  + L  +++     +A+K K  +   E +++  DL++   ++    +E+
Sbjct: 912  KIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVE---KEK 968

Query: 100  GAQDRRIQDLETELEKMEARLNAALREKTSLS-ANNATLEKQLIELTRTNELLKSKFS-- 156
             A + ++++L  E+  ++  +    +EK +L  A+   L+    E  + N L K+K    
Sbjct: 969  HATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLE 1028

Query: 157  --------------------ENGNQK---NLRILSLELMKLRN----------KRETKMR 183
                                E   +K   +L++    +M L N          K++ ++ 
Sbjct: 1029 QQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELN 1088

Query: 184  GMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKL-------VSIEKEKIDEKSETEKLLE 236
             + A+ E  +      Q+ L+E Q +I +LE +L         +EK + D   E E++ E
Sbjct: 1089 ALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISE 1148

Query: 237  YIEEISCASD-QVEKYKLDIAQLEENLKEKNDEIL-------SLKQSLEENIVILSKQVE 288
             +EE   A+  Q+E  K   A+ ++  ++  +  L       +L++   +++  L +Q++
Sbjct: 1149 RLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQID 1208

Query: 289  DLNVKCQLLEKEKE------DHVNRNREHNENLNAEMQNLKQKFILEQQ----------- 331
            +L    Q LEKEK       D V  N E      A ++ + +   LE Q           
Sbjct: 1209 NLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRT--LEDQMNEHRSKAEET 1266

Query: 332  ---------EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQT 382
                     +R KLQ +  ++   L +++ L S L +   ++ +++   K   EEE+K  
Sbjct: 1267 QRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAK 1326

Query: 383  LDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLL 442
                  LQ      + L +Q EEE +++AE  ++L +          K      Q T  L
Sbjct: 1327 NALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEEL 1386

Query: 443  QEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILAT 502
            +E    + Q L++     E+  A  +S    L+     LQ +      + E       A 
Sbjct: 1387 EEAKKKLAQRLQEAEEAVEAVNAKCSS----LEKTKHRLQNEIEDLMVDVERSNAAAAAL 1442

Query: 503  ESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGR 562
            +   + + ++L + + K    ++E++    S  ++   L  +L + +  + + LE  E  
Sbjct: 1443 DKKQRNFDKILAEWKQKYEESQSELE----SSQKEARSLSTELFKLKNAYEESLEHLETF 1498

Query: 563  KAEKENTTAE---LTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE-Q 618
            K E +N   E   LTE++        EL    K    QL+A ++E Q+ L E  A+ E +
Sbjct: 1499 KRENKNLQEEISDLTEQLGSSGKTIHELEKVRK----QLEAEKMELQSALEEAEASLEHE 1554

Query: 619  LNKIRDSYAKLLGHQNLKQKIKHVVKLKDEN-SQLKSEVSKLRCQLAKKKQSETKLQEEL 677
              KI  +    L    +K +I+  +  KDE   Q K    ++   L     +ET+ + E 
Sbjct: 1555 EGKILRAQ---LEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEA 1611

Query: 678  NKV 680
             +V
Sbjct: 1612 LRV 1614



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 136/699 (19%), Positives = 291/699 (41%), Gaps = 71/699 (10%)

Query: 37   SFQKSQRFKQQKESKQN--LNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRV 94
            + +KS+  +++ E K    L    D  L   A +   +++++   +  K+   LE +++ 
Sbjct: 862  ALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKE 921

Query: 95   LLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSK 154
            + +    ++    +L  +  K+E   +   R+   L    A +EK   E   T   +K+ 
Sbjct: 922  MNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEK---EKHATENKVKNL 978

Query: 155  FSE-NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQL 213
              E  G  + +  L+ E   L+   +  +  + A+++    K+    ++  + + ++  L
Sbjct: 979  TEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEED----KVNTLTKAKVKLEQQVDDL 1034

Query: 214  EGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLK 273
            EG L   +K ++D +    KL     ++    + +   + D  QL+E LK+K+ E+ +L 
Sbjct: 1035 EGSLEQEKKVRMDLERAKRKL---EGDLKLTQESIMDLENDKQQLDERLKKKDFELNALN 1091

Query: 274  QSLEENIVI---LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQ 330
              +E+   +   L K++++L  + + LE+E         E      A+++ L+     E 
Sbjct: 1092 ARIEDEQALGSQLQKKLKELQARIEELEEE--------LEAERTARAKVEKLRSDLSREL 1143

Query: 331  QE-REKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKL 389
            +E  E+L++        ++  K+  +   +     +E  ++ +       K+  D + +L
Sbjct: 1144 EEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL 1203

Query: 390  QQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSM 449
             ++ +  +R+ ++LE+E      E KL  + +     ++ K+ A             + M
Sbjct: 1204 GEQIDNLQRVKQKLEKE----KSEFKLELDDVTSNMEQIIKAKA-----------NLEKM 1248

Query: 450  VQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEY 509
             ++LED   +  S    T   + DL  + + LQ +  +  +  ++ +  I         Y
Sbjct: 1249 CRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTY 1308

Query: 510  VRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENT 569
             + L DL+ +   +E + K      LQ         +   +  R+Q E+E   KAE +  
Sbjct: 1309 TQQLEDLK-RQLEEEVKAKNALAHALQ-------SARHDCDLLREQYEEETEAKAELQRV 1360

Query: 570  TAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKL 629
             ++   E+ +WR  YE     T   Q + +  E  K+ L      A+E +  +    + L
Sbjct: 1361 LSKANSEVAQWRTKYE-----TDAIQ-RTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSL 1414

Query: 630  LGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLA---KKKQSETKLQEELNKVLGIKHF 686
                   +K KH  +L++E   L  +V +     A   KK+++  K+  E  +    K+ 
Sbjct: 1415 -------EKTKH--RLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQ----KYE 1461

Query: 687  DPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQESWK 725
            +         KE  +L T L +   N Y   +E  E++K
Sbjct: 1462 ESQSELESSQKEARSLSTELFK-LKNAYEESLEHLETFK 1499



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 148/749 (19%), Positives = 307/749 (40%), Gaps = 138/749 (18%)

Query: 42   QRFKQQKESKQN---LNVDKDTTLPASARKVKSSESKK----ESQKNDKDLKILE--KEI 92
            QR KQ+ E +++   L +D  T+      K K++  K     E Q N+   K  E  + +
Sbjct: 1211 QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSV 1270

Query: 93   RVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN---- 148
              L  +R        +L  +L++ EA ++   R K + +     L++QL E  +      
Sbjct: 1271 NDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALA 1330

Query: 149  ----------ELLKSKFSENGNQKN--LRILSL---ELMKLRNKRETKMRGMMAKQEGME 193
                      +LL+ ++ E    K    R+LS    E+ + R K ET    +   +E  E
Sbjct: 1331 HALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETD--AIQRTEELEE 1388

Query: 194  MKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 253
             K ++ QR L+E++  +  +  K  S+EK K   ++E E L+  +E  + A+  ++K + 
Sbjct: 1389 AKKKLAQR-LQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR 1447

Query: 254  DIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNE 313
            +  ++    K+K +E  S  +S ++    LS ++     K +   +E  +H+   +  N+
Sbjct: 1448 NFDKILAEWKQKYEESQSELESSQKEARSLSTEL----FKLKNAYEESLEHLETFKRENK 1503

Query: 314  NLNAEMQNLKQ------KFILEQQE-REKLQQKELQIDSLLQQEK--------------- 351
            NL  E+ +L +      K I E ++ R++L+ +++++ S L++ +               
Sbjct: 1504 NLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQL 1563

Query: 352  ---ELSSSLHQKLCSFQEEMVKEKN---LFEEELKQTLD------------------ELD 387
               ++ + + +KL    EEM + K       + L+ +LD                  +L+
Sbjct: 1564 EFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLN 1623

Query: 388  KLQQKEEQAERLVKQLEEEAKS-------------------------------------- 409
            +++ +   A R+  + +++ KS                                      
Sbjct: 1624 EMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQA 1683

Query: 410  RAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTAS 469
              EEL+ + E+ +      E+     ++   LL  +  S++   + + A     +    +
Sbjct: 1684 ELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQ----T 1739

Query: 470  EIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKE 529
            E+E+   E  + +EKA KA  +A  +  ++   + ++    RM  +++      +  + E
Sbjct: 1740 EVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1799

Query: 530  ITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYN 589
                 L+       +L+ +  +   +LE E+ R AE      +    I +     EE   
Sbjct: 1800 AEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRK 1859

Query: 590  KTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDEN 649
                 Q  +D  +++ +A   +   A+EQ N     +          +K++H +   +E 
Sbjct: 1860 NLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKF----------RKVQHELDEAEER 1909

Query: 650  SQL-KSEVSKLRCQLAKKKQSETK-LQEE 676
            + + +S+V+KLR   AK +   TK L EE
Sbjct: 1910 ADIAESQVNKLR---AKSRDIGTKGLNEE 1935



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 97/484 (20%), Positives = 213/484 (44%), Gaps = 74/484 (15%)

Query: 39   QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSS--ESKKESQKNDKDLKILEKEIRVLL 96
            QK +  + + ES Q     +  +L     K+K++  ES +  +   ++ K L++EI  L 
Sbjct: 1458 QKYEESQSELESSQK----EARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLT 1513

Query: 97   QERGAQDRRIQDLETELEKMEAR---LNAALRE-KTSLSANNATLEKQLIELTRTNELLK 152
            ++ G+  + I +LE   +++EA    L +AL E + SL      + +  +E  +    ++
Sbjct: 1514 EQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE 1573

Query: 153  SKFSENGNQ----KNLRILSLELMKLRNKRETKMRG----MMAKQEG----MEMKLQVTQ 200
             K +E   +    K   +  ++ ++     ET+ R     +  K EG    ME++L    
Sbjct: 1574 RKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHAN 1633

Query: 201  RSLEESQGKIAQLEGKLVSIEKEKIDE---------------------KSETEKLLEYIE 239
            R   E+Q ++  L+  L   + +  D                      ++E E+L   +E
Sbjct: 1634 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVE 1693

Query: 240  EISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK 299
            +   +    E+  ++ ++  + L  +N  +++ K+ ++ ++  L  +VE+   +C+  E+
Sbjct: 1694 QTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEE 1753

Query: 300  EKE----------DHVNRNREHNENLNAEMQNLKQ-----KFILEQQEREKLQQKELQID 344
            + +          + + + ++ + +L    +N++Q     +  L++ E+  L+  + Q+ 
Sbjct: 1754 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQ 1813

Query: 345  SLLQQEKELSSSLHQ---------KLCSFQEEMVKEKNLFEEELKQTL----DELDKLQQ 391
             L  + +EL + L           K     E  +KE     EE ++ L    D +DKLQ 
Sbjct: 1814 KLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQL 1873

Query: 392  KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 451
            K +  +R  ++ EE+A +   + + ++ +L   EAE E++  A +Q   L  +  D   +
Sbjct: 1874 KVKAYKRQAEEAEEQANTNLSKFRKVQHEL--DEAE-ERADIAESQVNKLRAKSRDIGTK 1930

Query: 452  SLED 455
             L +
Sbjct: 1931 GLNE 1934


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score =  117 bits (292), Expect = 5e-26
 Identities = 149/652 (22%), Positives = 290/652 (44%), Gaps = 72/652 (11%)

Query: 70   KSSESKKESQKNDKDLKILEKEI---RVLLQERGAQDRRIQDLETELEKMEARLNAALR- 125
            ++ E + E    +K+ ++L+K+I   ++  ++  A ++   +LE E  K++  L++    
Sbjct: 626  RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNL 685

Query: 126  --EKTSLSANNATLEKQLIELTRTNELLKS----------KFSENGNQKNLRILSLELMK 173
              +  SL   N+ L+++ +EL R  E LK           +  E  ++K      LEL+K
Sbjct: 686  TFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLK 745

Query: 174  LRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEK 233
               K+  ++       +G++++ Q  Q++LE S  KI QLE +L  +E     E    +K
Sbjct: 746  ASFKKTERLE---VSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM----ENQTLQK 798

Query: 234  LLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVK 293
             LE ++  S   +Q+EK    + Q    L++   ++    + L +   I    +E+ NVK
Sbjct: 799  NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVK 858

Query: 294  CQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFI----LEQQEREKLQQKELQIDSLLQQ 349
               LEKE           N+ L+ E+   K+  +    LE++ +E +++  + I +L+  
Sbjct: 859  IGNLEKE-----------NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTL 907

Query: 350  EKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKS 409
             ++L S   +KL +  ++M  +      EL++     ++L   E+  +   K LE + +S
Sbjct: 908  REDLVS---EKLKT--QQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLES 962

Query: 410  RAEE-LKLLEEKLKGKEAELEKSSAAHTQATLLL---QEKYDSMVQSLEDVTAQFESYKA 465
              ++ L++ EEK+   EA LE+S+  + Q    L   ++ Y+++ Q  +D     +S   
Sbjct: 963  TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQR-QDEERMVQSSPP 1021

Query: 466  LTASEIEDLKLENSSLQ--EKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALK 523
            ++    ED K E  S +   +  K      +V+      ++  Q     L  L+T++   
Sbjct: 1022 ISG---EDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNL 1078

Query: 524  ETEIKEI---TVSFLQKITDLQNQ----------LKQQEEDFRKQLEDEEGRKAEKENTT 570
            + +I  +   TVS  ++ T LQ Q          L  Q      Q      +++  EN  
Sbjct: 1079 QAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENEN 1138

Query: 571  AELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLL 630
              + +E    + LY+ L    +  +L  +    E ++L+++HG  +     +   +  L 
Sbjct: 1139 ESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLE 1198

Query: 631  GHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLG 682
               N  Q +K   +L+D    LK E  K+   L + K  ET +  E  K+ G
Sbjct: 1199 DRYN--QLLKQKGQLEDLEKMLKVEQEKM---LLENKNHET-VAAEYKKLCG 1244



 Score =  112 bits (280), Expect = 1e-24
 Identities = 160/678 (23%), Positives = 299/678 (44%), Gaps = 90/678 (13%)

Query: 40  KSQRFKQQKESKQNLNVDKDTTLPASARKVKS---------SESKKESQKNDKDLKILEK 90
           K +R +Q+ E K    +D    L     ++K          S+++      D+   + EK
Sbjct: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREK 318

Query: 91  EIRV--LLQERGAQDRRIQDLE---TELEKMEARLNAALREKTSLS---ANNATLEKQLI 142
            +RV  L  E      R+ D+E     +E+++      L  KT L            +L 
Sbjct: 319 AVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378

Query: 143 ELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQV---- 198
           EL + N  LK+K  +   ++++     +  K+    E  M   MA+++ M+  L +    
Sbjct: 379 ELEKENLQLKAKLHDMEMERDM-----DRKKIEELMEENMTLEMAQKQSMDESLHLGWEL 433

Query: 199 -----TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 253
                T    E  Q  +     +L S    K++   E + L + +EE+    D VE    
Sbjct: 434 EQISRTSELSEAPQKSLGHEVNELTSSRLLKLE--MENQSLTKTVEELRTTVDSVEGNAS 491

Query: 254 DIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNE 313
            I ++E     K ++ LS K  + EN ++  KQ       CQ L K   D +    +  +
Sbjct: 492 KILKME-----KENQRLSKKVEILENEIVQEKQSLQ---NCQNLSK---DLMKEKAQLEK 540

Query: 314 NLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKN 373
            +    +N +++  + +QE E L Q      S L+Q  ++S+    K      ++ KE  
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTV----SSLRQRSQISAEARVK------DIEKENK 590

Query: 374 LFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSA 433
           +  E +K+T  +L K++ ++ Q ++ ++  +E+ + RAEEL+     L+ KE EL +   
Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE-RAEELENELHHLE-KENELLQKKI 648

Query: 434 AHTQATL----LLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAG 489
            + + T      L+++   + +    +    +S+K LT  ++E L+ ENS L E+  +  
Sbjct: 649 TNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLT-FQLESLEKENSQLDEENLELR 707

Query: 490 KNAEDV--------QHQILATE-SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 540
           +N E +        Q Q+   E  S +E ++  L+L  K++ K+TE  E++   L    D
Sbjct: 708 RNVESLKCASMKMAQLQLENKELESEKEQLKKGLEL-LKASFKKTERLEVSYQGL----D 762

Query: 541 LQNQ-LKQQEEDFRKQLE--DEEGRKAEKENTTAELT-EEINKWRLLYEELYNKTKPFQL 596
           ++NQ L++  E+  K+++  + E +  E EN T +   EE+       E+L  + K  + 
Sbjct: 763 IENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQ 822

Query: 597 QLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEV 656
           +    E +K+ L  E+   ++Q  +I+D+    L   N+K     +  L+ EN  L  E+
Sbjct: 823 ETSQLEKDKKQLEKENKRLRQQA-EIKDT---TLEENNVK-----IGNLEKENKTLSKEI 873

Query: 657 S--KLRCQLAKKKQSETK 672
              K  C   K+ + E K
Sbjct: 874 GIYKESCVRLKELEKENK 891



 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 137/628 (21%), Positives = 264/628 (42%), Gaps = 124/628 (19%)

Query: 139 KQLIELTRTNELL--KSKFSENGNQKNLRILSLEL---MKLRNKRE--TKMRGM-MAKQE 190
           +QLI ++  N L+  K+ FSE G ++  ++L L L   ++ + K E   +++G+    + 
Sbjct: 95  QQLIMMSLPNVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKA 154

Query: 191 GMEMKLQVTQRSLEE------------SQGKIAQLEGKLVSIEKEKIDEKSE-TEKLLEY 237
            +   +Q    + E             SQ  I  L   +    K  IDE+ E +E ++E 
Sbjct: 155 AVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIEL 214

Query: 238 IEEIS---------------CASDQVEKY-------------KLDIAQLEENLKEKNDEI 269
            EE                 C S  +++              K  I +L + L+EK +++
Sbjct: 215 SEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQL 274

Query: 270 LSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILE 329
           L  KQ LE                      + E  + R ++ N NL ++ ++ +    + 
Sbjct: 275 LDCKQELE----------------------QMEIELKRLQQENMNLLSDARSAR----MY 308

Query: 330 QQEREKLQQKELQIDSLLQQEKELSSSLH---------QKLCSFQEEMVKEKNLFEEELK 380
           + E + L++K +++D L  +       LH         ++L    + +++ K + E++L+
Sbjct: 309 RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLE 368

Query: 381 QTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATL 440
            T    DKL + E++  +L  +L +    R  + K +EE L  +   LE +       +L
Sbjct: 369 GTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEE-LMEENMTLEMAQKQSMDESL 427

Query: 441 LLQEKYDSMVQSLEDVTAQFES----YKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQ 496
            L  + + + ++ E   A  +S       LT+S +  L++EN SL +   +     + V+
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVE 487

Query: 497 ---HQILATESSNQ-----------EYVRMLLDLQ-----TKSALKETEIKEITVSFLQK 537
               +IL  E  NQ           E V+    LQ     +K  +KE    E T+  L++
Sbjct: 488 GNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547

Query: 538 ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQ 597
            ++ Q ++ +QE +   Q      R+  + +  A + +   + ++L+E +    K    +
Sbjct: 548 NSERQIKILEQENEHLNQTVSSL-RQRSQISAEARVKDIEKENKILHESI----KETSSK 602

Query: 598 LDAFEVEKQAL------LNEHGAAQEQL-NKIR--DSYAKLLGHQ--NLKQKIKHVVKLK 646
           L   E EK+ +        E G   E+L N++   +   +LL  +  NLK   + +  L+
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALE 662

Query: 647 DENSQLKSEVSKLRCQLAKKKQSETKLQ 674
            ENS+L+ E  KL+  L   K    +L+
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQLE 690



 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 137/595 (23%), Positives = 261/595 (43%), Gaps = 95/595 (15%)

Query: 27   KTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESK----------- 75
            K+LE     +   K Q  K+ K  +Q   + KDTTL  +  K+ + E +           
Sbjct: 818  KSLEQETSQLEKDKKQLEKENKRLRQQAEI-KDTTLEENNVKIGNLEKENKTLSKEIGIY 876

Query: 76   -------KESQKNDKDL----KILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAAL 124
                   KE +K +K+L     I  K +  L ++  ++  + Q +  +LEK+   L    
Sbjct: 877  KESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHEL---- 932

Query: 125  REKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNK-RETKMR 183
             EK  L+      ++Q  +     +LL+SK  E+  +K+L I   ++  L  +  E+   
Sbjct: 933  -EKIGLNKERLLHDEQSTD--DRYKLLESKL-ESTLKKSLEIKEEKIAALEARLEESTNY 988

Query: 184  GMMAKQEGMEMKLQVTQRSLEESQGKIAQ----LEGKLVSIEKEKIDEKSETEKLLEYIE 239
                +QE   +K         + + ++ Q    + G+    E+E  +   E  K+ + + 
Sbjct: 989  NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1048

Query: 240  EI--SCASDQVEK--YKLDIAQLEENLKEKNDEILSLKQ---SLEENIVILSKQVEDLNV 292
            E+  + A+ Q EK   K  + QLE        +IL+L++   SL+E    L  Q   L V
Sbjct: 1049 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1108

Query: 293  KCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKE 352
            +   L  +    +N+N +      + ++N  +  I E+++ + L       DSL++  ++
Sbjct: 1109 ENSTLNSQSTSLMNQNAQLLIQ-QSSLENENESVIKEREDLKSL------YDSLIKDHEK 1161

Query: 353  LSSSLHQKLCSFQEEMVKE--------KNLFEEELKQTLDELDKLQQKEEQAERLVKQLE 404
            L   LH++  S  E ++ +        KNL E E +   D  ++L +++ Q E L K L+
Sbjct: 1162 L-ELLHERQASEYESLISKHGTLKSAHKNL-EVEHRDLEDRYNQLLKQKGQLEDLEKMLK 1219

Query: 405  EEAKSRAEELKLLEEK-LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESY 463
             E     +E  LLE K  +   AE +K    + +    L   Y  +++  E +    ++ 
Sbjct: 1220 VE-----QEKMLLENKNHETVAAEYKKLCGENDR----LNHTYSQLLKETEVLQTDHKNL 1270

Query: 464  KALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQ------------EYVR 511
            K+L    + + KLE + L+ + +K  +  +  Q  I +T+ +NQ            E  R
Sbjct: 1271 KSL----LNNSKLEQTRLEAEFSKLKEQYQ--QLDITSTKLNNQCELLSQLKGNLEEENR 1324

Query: 512  MLLD------LQTKSALKET-EIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDE 559
             LLD      LQ ++ L++  E K++     ++  D  N+L++Q+E   +++ D+
Sbjct: 1325 HLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1379



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 130/583 (22%), Positives = 246/583 (42%), Gaps = 79/583 (13%)

Query: 39   QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKK---ESQKNDKDL-KILEKEIRV 94
            Q  Q  K  K++ + L   +D      +    S E  K   ESQ+  ++L K+ ++ I V
Sbjct: 991  QLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV 1050

Query: 95   ------LLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN 148
                  L  E+ A   +++ LET+   ++A++ A  R+  SL   N TL+ Q  +L   N
Sbjct: 1051 ERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVEN 1110

Query: 149  ELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG 208
              L S+ +   NQ N ++L ++   L N+ E+ ++            L+    SL +   
Sbjct: 1111 STLNSQSTSLMNQ-NAQLL-IQQSSLENENESVIK--------EREDLKSLYDSLIKDHE 1160

Query: 209  KIAQLEGKLVSIEKEKIDE----KSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKE 264
            K+  L  +  S  +  I +    KS  + L     ++    +Q+ K K  +  LE+ LK 
Sbjct: 1161 KLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKV 1220

Query: 265  KNDEILSLKQSLEENIVILSKQV----EDLNVKCQLLEKEKE----DH------VNRNRE 310
            + +++L L+    E +    K++    + LN     L KE E    DH      +N ++ 
Sbjct: 1221 EQEKML-LENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKL 1279

Query: 311  HNENLNAEMQNLKQKFILEQQEREKL-QQKEL--QIDSLLQQEKELSSSLHQKLC----S 363
                L AE   LK+++        KL  Q EL  Q+   L++E        Q L     +
Sbjct: 1280 EQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRT 1339

Query: 364  FQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKG 423
              E+ ++ K+LF  E +Q +D+L++L++++E+                     LEEK+  
Sbjct: 1340 LLEQNMESKDLFHVEQRQYIDKLNELRRQKEK---------------------LEEKIMD 1378

Query: 424  KEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIED----LKLENS 479
            +    + S        + L  K   +++S +D+  + +    LT +  +     L+L + 
Sbjct: 1379 QYKFYDPSPPRRRGNWITL--KMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQ 1436

Query: 480  SLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQT----KSALKETEIKEITVSFL 535
              Q+ ++    + ED   Q L T+ S+   ++ L  L+     K  +K    + ++++ L
Sbjct: 1437 DSQDSSSVGSNSLED--GQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDL 1494

Query: 536  QKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEIN 578
             +   L  Q     E+     +   G++ ++    A  T  IN
Sbjct: 1495 VQSMVLAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAIN 1537


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score =  116 bits (291), Expect = 6e-26
 Identities = 167/746 (22%), Positives = 325/746 (43%), Gaps = 117/746 (15%)

Query: 39   QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQE 98
            QK++ F Q  E+++N  + + +T     + ++   +K     N  + +I E+  RV   +
Sbjct: 1857 QKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKM----NLLNQQIQEELSRVTKLK 1912

Query: 99   RGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSEN 158
              A++ +  DLE  L    A LN ++         +A ++ +L+E    N  LK   SE 
Sbjct: 1913 ETAEEEK-DDLEERLMNQLAELNGSIGNYCQ-DVTDAQIKNELLESEMKN--LKKCVSEL 1968

Query: 159  GNQKNLRILSLELMKLRNKRETKMRGMMA-------KQEGMEMKLQVTQRSLEESQGKIA 211
              +K       +L+K + K E+++R           K+ G +   +  Q  L+E Q ++ 
Sbjct: 1969 EEEKQ------QLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVK 2022

Query: 212  QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS 271
            QL+   +  + EKI     T K LE+++  S     +E  K ++AQ  E+ K+   E+ S
Sbjct: 2023 QLQKDCIRYQ-EKISALERTVKALEFVQTES--QKDLEITKENLAQAVEHRKKAQAELAS 2079

Query: 272  LKQSLEENIVILSKQVEDLNVKCQL-LEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQ 330
             K  L++     ++ + D N+K +  L+  KE   ++ ++ +E+L   ++  ++K + E+
Sbjct: 2080 FKVLLDDTQSEAARVLAD-NLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEK 2138

Query: 331  QE---------REKLQQKE----LQI-----DSLLQQEKELSSSLHQKLCSFQEEMVKEK 372
            +          REK+  +E    +Q+     D  +QQ +E   S   +L +F + M    
Sbjct: 2139 KNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSM---- 2194

Query: 373  NLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEK-- 430
            +  +++  + +DE  K ++K   A   ++  EEE + + +   +L+++L+     +E+  
Sbjct: 2195 SSLQDDRDRVIDEAKKWERKFSDA---IQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELK 2251

Query: 431  -------------SSAAHTQATL------LLQEKYDSMVQSLEDVTAQFESYK---ALTA 468
                          S A T+  L       LQ +   ++  LE+    + S +   A   
Sbjct: 2252 INISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLE 2311

Query: 469  SEIEDLKLENSSLQ---EKAAKAGKNAEDVQHQILAT-ESSNQEYVRMLLDLQTKSAL-- 522
            SE++ LK + + L    EK  +   N E +  Q  A  ++S   Y ++  DLQ    L  
Sbjct: 2312 SELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTS 2371

Query: 523  ---KETEIKEITVSFL--------------------QKITDLQNQLKQQEEDFRKQLEDE 559
               +E  +KE  +  L                    ++I +L+N L Q+EE+    LE+E
Sbjct: 2372 RLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEE-NIVLEEE 2430

Query: 560  EGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQL 619
              +  +K N   E  + I K     E +  K      QLD+F     +L N+        
Sbjct: 2431 NKKAVDKTNQLMETLKTIKK-----ENIQQKA-----QLDSFVKSMSSLQNDRDRIVGDY 2480

Query: 620  NKIRDSYAKLL--GHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEEL 677
             ++ + +  ++    Q +++      KLK+E   L+S +  L  + AK      + +E+L
Sbjct: 2481 QQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDL 2540

Query: 678  NKVLGIKHFDPSKAFHHESKENFALK 703
            N+V+ IK     +    + ++N  L+
Sbjct: 2541 NQVITIKDSQQKQLLEVQLQQNKELE 2566



 Score =  112 bits (281), Expect = 9e-25
 Identities = 179/785 (22%), Positives = 328/785 (41%), Gaps = 134/785 (17%)

Query: 48   KESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQ 107
            K + + L  DK+  L      +KSS+  + ++  +K  K L+KE  +LLQ         +
Sbjct: 1573 KLALEGLTEDKEK-LVKEIESLKSSKIAESTEWQEKH-KELQKEYEILLQS-------YE 1623

Query: 108  DLETELEKMEARLNAALREKTSL-------SANNATLEKQLIELTRTNELLKSKFSENGN 160
            ++  E E+++  + A  +EK  L        AN    EKQL E  +  E +K K  +   
Sbjct: 1624 NVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAK 1683

Query: 161  QKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVT---QRSLEESQGKIAQLEGKL 217
             K  +IL LE    R + E    G  AK E ME  L      +  LE  + +   L  K 
Sbjct: 1684 SKQQKILELEEENDRLRAEVHPAGDTAK-ECMETLLSSNASMKEELERVKMEYETLSKKF 1742

Query: 218  VSIEKEKIDEKSETEKLLEYIE---EISCASDQVEKYKLDIAQLEENLK------EKNDE 268
             S+  EK     E + L   IE         +  EK+       EE  +      E+ D 
Sbjct: 1743 QSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDS 1802

Query: 269  I-LSLKQSLEENIVILS--------------------KQVEDLNVKCQLLEKEKEDHVNR 307
            + +S + +  E++                        +Q++ L  +   LE+EK+    +
Sbjct: 1803 LSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQ----K 1858

Query: 308  NREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQ-EKELSSSLHQKLCSFQE 366
            N+E ++ L  E   L  +   +  E + LQ++  +++ L QQ ++ELS     ++   +E
Sbjct: 1859 NKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELS-----RVTKLKE 1913

Query: 367  EMVKEKNLFEEELKQTLDEL------------------DKLQQKEEQAERLVKQLEEEAK 408
               +EK+  EE L   L EL                  + L+ + +  ++ V +LEEE +
Sbjct: 1914 TAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQ 1973

Query: 409  SRAEELKLLE--------EKLKGKEAEL-EKSSAAHTQATLLLQEKYDSMVQSLEDVTAQ 459
               +E   +E        EK++G + E   KS A   Q   LL+EK   + Q  +D    
Sbjct: 1974 QLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQE--LLKEKQQEVKQLQKDCIRY 2031

Query: 460  FESYKAL--TASEIEDLKLENSS----LQEKAAKAGKNAEDVQHQI----LATESSNQEY 509
             E   AL  T   +E ++ E+       +E  A+A ++ +  Q ++    +  + +  E 
Sbjct: 2032 QEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEA 2091

Query: 510  VRMLLD-LQTKSALKETEIKEITVSFLQKITDLQNQLKQQEE-------DFRKQLEDEEG 561
             R+L D L+ K  L+  + + +     QK  DL+ +L+Q EE       + +++L+    
Sbjct: 2092 ARVLADNLKLKKELQSNK-ESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRR 2150

Query: 562  RKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNK 621
             K   E T  E+   +NK     ++L         QL AF     +L ++     ++  K
Sbjct: 2151 EKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKK 2210

Query: 622  IRDSYAKLL--GHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAK----------KKQS 669
                ++  +    + ++ K  +   LKD+  Q+   + +L+  +++          K Q+
Sbjct: 2211 WERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQT 2270

Query: 670  ETKLQEEL-------NKVLGIKHFDPSKAFHHESKENFA-----LKTPLKEGNTNCYRAP 717
            E +LQ+++       NK L +   + ++  +H S+   A     LK+ LK+  T+   + 
Sbjct: 2271 EVQLQQKVCDTLQGENKEL-LSQLEETRHLYHSSQNELAKLESELKS-LKDQLTDLSNSL 2328

Query: 718  MECQE 722
             +C+E
Sbjct: 2329 EKCKE 2333



 Score =  112 bits (280), Expect = 1e-24
 Identities = 153/653 (23%), Positives = 287/653 (43%), Gaps = 68/653 (10%)

Query: 67   RKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALRE 126
            +++  S+++ E Q   K    L+ E + LL +           + EL K+E+ L +   +
Sbjct: 2261 KQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQ 2320

Query: 127  KTSLSANNATLEKQ---LIELTRTNE--LLKSKFSENGNQKNL---RILSLELMKLRNKR 178
             T LS +    ++Q   L  + R  E  +  SKFS    + +L   R L+  L +  N +
Sbjct: 2321 LTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMK 2380

Query: 179  ETKMRGMMA-KQEGMEMKL----QVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEK 233
            E K+  +++ K+E +++ +    Q   + ++E +  ++Q E + + +E+E      +T +
Sbjct: 2381 EQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQ 2440

Query: 234  LLEYIEEISCASDQVEKYKLD-IAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNV 292
            L+E ++ I   + Q +K +LD   +   +L+   D I+   Q LEE  + +  + + L  
Sbjct: 2441 LMETLKTIKKENIQ-QKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQ 2499

Query: 293  KCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKL------QQKELQIDSL 346
            +      + ++ +   R H ++LN+E   L  + I  +++  ++      QQK+L ++  
Sbjct: 2500 EAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQL-LEVQ 2558

Query: 347  LQQEKELS---SSLHQKLCSFQ---EEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLV 400
            LQQ KEL    + L +KL   +   E++ +  N  +EE +    E++ L+    Q  R V
Sbjct: 2559 LQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQV 2618

Query: 401  KQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQF 460
              L+EE       L L   +LK KE E+ + SA  + +           +  LE+     
Sbjct: 2619 TALQEEG-----TLGLYHAQLKVKEEEVHRLSALFSSS--------QKRIAELEEELVCV 2665

Query: 461  ESYKALTASEIED-LKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTK 519
            +   A    EIED LK E   L   A       E  + ++        E  R L++++ K
Sbjct: 2666 QKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERV-------AELARDLVEMEQK 2718

Query: 520  SALKETEIKEITV---SFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKE-NTTAELTE 575
              +   E K +T    SF + ++ LQN      E+      DE  RK +      A+L E
Sbjct: 2719 LLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEEL-----DELKRKYDASLKELAQLKE 2773

Query: 576  E--INKWR--LLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG 631
            +  +N+ R  LL E  ++     +  L   E   Q LL++        +++ DSY     
Sbjct: 2774 QGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSY----- 2828

Query: 632  HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIK 684
               ++   K +  L++E   L +E+ K R     K++S  +      +V  +K
Sbjct: 2829 -NQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLK 2880



 Score =  100 bits (249), Expect = 5e-21
 Identities = 149/673 (22%), Positives = 293/673 (43%), Gaps = 95/673 (14%)

Query: 36   VSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKN-DKDLK-----ILE 89
            +S ++ Q   Q KE      +   T L A  ++++ + ++ E Q+  D + +     +L 
Sbjct: 742  LSEERDQLLSQVKE------LSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLT 795

Query: 90   KEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNE 149
            ++I  L  E  ++D +I+ L+ EL+ ++ + +       SL +     E +++E      
Sbjct: 796  EQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVR 855

Query: 150  LLKSKFSENG---NQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEES 206
             + SK  E     +QK L I  ++ + L  KR+ +      +Q   E   QVT+ S   +
Sbjct: 856  HISSKVEELSQALSQKELEITKMDQLLLEKKRDVET----LQQTIEEKDQQVTEISFSMT 911

Query: 207  QGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKN 266
            +        K+V + +EK     E + L E +  +S A +  ++   +  ++   LK+  
Sbjct: 912  E--------KMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNY 963

Query: 267  DEILSL----KQSLEENIVILSKQVEDLNVKCQ---LLEKEKEDHVNRNREHNENLNAEM 319
            DE+       K+ L+    +L K+ E    K Q   +  KE    V+R  E   NL  E 
Sbjct: 964  DEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDES 1023

Query: 320  QNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEEL 379
               K++  L + ER ++++ +   ++    EK ++S   Q++  + ++ + EK   E EL
Sbjct: 1024 ---KKEIPLSETERGEVEEDK---ENKEYSEKCVTSKC-QEIEIYLKQTISEK---EVEL 1073

Query: 380  KQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQAT 439
            +    +L++    EEQ + LVKQ+ +  + +  ++ LL+ ++   +A ++K   ++T A+
Sbjct: 1074 QHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDAS 1133

Query: 440  LLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI 499
                   DS+    E V          T S  E  K E   L+EK     K  E +Q ++
Sbjct: 1134 -----DGDSVALVKETVVIS----PPCTGSS-EHWKPE---LEEKILALEKEKEQLQKKL 1180

Query: 500  LATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDE 559
                +S             K+ LK+ + KE           L+ +LKQQ++D+ +  E  
Sbjct: 1181 QEALTSR------------KAILKKAQEKE---------RHLREELKQQKDDYNRLQEQF 1219

Query: 560  EGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAF-------EVEKQALLNEH 612
            + +  E EN    + +++ + ++   E  +   P   Q ++        E   +A    H
Sbjct: 1220 DEQSKENEN----IGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHH 1275

Query: 613  GAAQEQLNKIRD------SYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKK 666
                 + N   D        + L G  ++ Q    + +++ E  +L+ +VS    +L KK
Sbjct: 1276 TQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKK 1335

Query: 667  KQSETKLQEELNK 679
             +   +LQE++NK
Sbjct: 1336 SEEVFQLQEQINK 1348



 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 132/664 (19%), Positives = 289/664 (43%), Gaps = 62/664 (9%)

Query: 69   VKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKT 128
            +K+  ++ E Q  + D +I  K+++V L E   +   I +     ++++ +L AAL  + 
Sbjct: 1436 IKALHTQLEMQAKEHDERI--KQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRK 1493

Query: 129  SLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAK 188
                 N +L+++L     T E L    ++  +Q          +  +NK +  + G +A 
Sbjct: 1494 EALKENKSLQEELSLARGTIERLTKSLADVESQ----------VSAQNKEKDTVLGRLAL 1543

Query: 189  -QEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIE-----EIS 242
             QE  +  +    RSL E+Q   +  E   +++E    D+    EKL++ IE     +I+
Sbjct: 1544 LQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDK----EKLVKEIESLKSSKIA 1599

Query: 243  CASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE 302
             +++  EK+K ++ +  E L +  + + +  + ++  +  + ++ ++L  K +  E  K+
Sbjct: 1600 ESTEWQEKHK-ELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKK 1658

Query: 303  DHVNRNREHNENLNAEMQNLKQKFILEQQER-----EKLQQKELQIDSLLQQEKELSSSL 357
            +   + +E  + +  EM+   +KF   +Q++     E+  +   ++       KE   +L
Sbjct: 1659 ETEKQLQEAEQEME-EMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETL 1717

Query: 358  HQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLE---------EEAK 408
                 S +EE+ + K  +E   K+    + +     E+ + L  Q+E         E  +
Sbjct: 1718 LSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATE 1777

Query: 409  SRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALT- 467
                +  + EE  +    E E+  +          E   S   +   V+  F S+  +  
Sbjct: 1778 KHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINN 1837

Query: 468  -ASEIEDLKLENSSLQEKAAK---AGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALK 523
               +I+ LK   + L+E+  K     +  E+ ++ +L+  S+    ++ML +  TK  L 
Sbjct: 1838 YLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLL 1897

Query: 524  ETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLL 583
              +I+E     L ++T L+   +++++D  ++L ++    AE   +     +++   ++ 
Sbjct: 1898 NQQIQE----ELSRVTKLKETAEEEKDDLEERLMNQ---LAELNGSIGNYCQDVTDAQIK 1950

Query: 584  YEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVV 643
             E L ++ K  +  +   E EKQ L+ E    + ++ K  +   K+ G Q       H  
Sbjct: 1951 NELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRK--EYLEKIQGAQKEPGNKSHAK 2008

Query: 644  KLKDENSQLKSEVSKLR--CQLAKKKQSETK--------LQEELNKVLGIKHFDPSKAFH 693
            +L++   + + EV +L+  C   ++K S  +        +Q E  K L I   + ++A  
Sbjct: 2009 ELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVE 2068

Query: 694  HESK 697
            H  K
Sbjct: 2069 HRKK 2072



 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 153/730 (20%), Positives = 322/730 (44%), Gaps = 99/730 (13%)

Query: 45   KQQKESKQNLNVDKD---TTLPASARKVKSSESKKESQKNDKDLKIL---EKEIRVLLQE 98
            +QQ+   QN     +   T L AS R++ S   ++ + K  K + +L   E+ I+V + E
Sbjct: 2343 RQQEADIQNSKFSYEQLETDLQAS-RELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAE 2401

Query: 99   -RGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSE 157
             R   D+ I++LE  L + E   N  L E+          +K + +  +  E LK+   E
Sbjct: 2402 LRQQHDKEIKELENLLSQEEEE-NIVLEEEN---------KKAVDKTNQLMETLKTIKKE 2451

Query: 158  NGNQK-NLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGK 216
            N  QK  L      +  L+N R+  +      +E     +    + ++E+  +  +L+ +
Sbjct: 2452 NIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEE 2511

Query: 217  LVSIEKEKIDEKSETEKL----LEYIEEIS---CASDQVEKYKLDIAQLEENLKEKNDEI 269
            +  +     D  SE  KL    ++Y E+++      D  +K  L++ QL++N KE  ++ 
Sbjct: 2512 IRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEV-QLQQN-KELENKY 2569

Query: 270  LSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILE 329
              L++ L+E+     +  EDL      L++EK+D      +  E+L   +  L ++    
Sbjct: 2570 AKLEEKLKES----EEANEDLRRSFNALQEEKQDL----SKEIESLKVSISQLTRQVTAL 2621

Query: 330  QQE--------REKLQQKEL-QIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELK 380
            Q+E        + K++++E+ ++ +L    ++  + L ++L   Q+E  K+    E++LK
Sbjct: 2622 QEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLK 2681

Query: 381  QTLDELDK----LQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHT 436
            + L  L      ++ + E AE  V +L  +     ++L ++ ++ KG  A+++    + +
Sbjct: 2682 KELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMS 2741

Query: 437  QATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDV- 495
                 LQ   D   + L+++  ++++    +  E+  LK +    +E+ A   + A  + 
Sbjct: 2742 S----LQNSRDHANEELDELKRKYDA----SLKELAQLKEQGLLNRERDALLSETAFSMN 2793

Query: 496  ---QHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQ---LKQQE 549
               ++ +   E  NQ+ +     L   S+  E    ++  SF + +  LQN+   L  + 
Sbjct: 2794 STEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQ-SFSKAMASLQNERDHLWNEL 2852

Query: 550  EDFRKQLEDEEGRKAEKENTTAE-----------------LTEEINKWRLLYEEL---YN 589
            E FRK  E ++   A+   + AE                 L +E+   +  Y ++     
Sbjct: 2853 EKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEIT 2912

Query: 590  KTKPFQLQLD-------AFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHV 642
            +  P + QL        AF++ ++ L  E+ + Q +L+++R   +    H+  + K +++
Sbjct: 2913 ELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHER-RMKEQYL 2971

Query: 643  VKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFAL 702
            + + D++ QL    S L+  + + + S ++ Q    KV   +   P  +   +  +N   
Sbjct: 2972 MAISDKDQQL----SHLQNLIRELRSSSSQTQP--LKVQYQRQASPETSASPDGSQNLVY 3025

Query: 703  KTPLKEGNTN 712
            +T L     N
Sbjct: 3026 ETELLRTQLN 3035



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 159/683 (23%), Positives = 294/683 (43%), Gaps = 68/683 (9%)

Query: 27   KTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLK 86
            K LE+ K  ++     R K Q E      +  DT   A+     + + KKE Q N + +K
Sbjct: 2054 KDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVK 2113

Query: 87   ILEKEIRVLLQER--GAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIEL 144
               K+    L+ R   A+++ +++ +   EK++A     +  + ++     TL K+  E+
Sbjct: 2114 SQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEV 2173

Query: 145  TRTNELLKSKFSE----NGNQKNLRILSLELMKLRNKRETKMR-GMMAKQEGMEMK---L 196
             +  E L S  ++      +  +L+     ++    K E K    + +K+E + +K    
Sbjct: 2174 QQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNC 2233

Query: 197  QVTQRSLEESQGKIAQLEGKLVSIEKEK--IDEKSETEKLLEYIEEISCASDQVEKYKLD 254
             V +  L +    + +L+  +  +E +K   + K++TE  L   ++  C + Q E  +L 
Sbjct: 2234 SVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQL---QQKVCDTLQGENKEL- 2289

Query: 255  IAQLEE--NLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHN 312
            ++QLEE  +L   +   L+    LE  +  L  Q+ DL+     LEK KE   N      
Sbjct: 2290 LSQLEETRHLYHSSQNELA---KLESELKSLKDQLTDLS---NSLEKCKEQKGNLEGIIR 2343

Query: 313  ENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEK 372
            +   A++QN   KF  EQ E +            LQ  +EL+S LH+++   +++++   
Sbjct: 2344 QQ-EADIQN--SKFSYEQLETD------------LQASRELTSRLHEEINMKEQKIISLL 2388

Query: 373  NLFEEELKQTLDELDKLQQKE-EQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKS 431
            +  EE ++  + EL +   KE ++ E L+ Q EEE     EE K   +K       L+  
Sbjct: 2389 SGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTI 2448

Query: 432  SAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKN 491
               + Q    L     SM     D       Y+ L    +  +  ++  +QE AA+  K 
Sbjct: 2449 KKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKL 2508

Query: 492  AEDVQHQILATESSNQEYVRMLLDL-QTKSALKETEIKEITVSFLQKITDLQNQLKQQEE 550
             E+++      +  N E  ++  +L Q +  L +     IT+   Q+   L+ QL+Q   
Sbjct: 2509 KEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQV----ITIKDSQQKQLLEVQLQQ--- 2561

Query: 551  DFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLN 610
               K+LE++  +  EK   + E  E++   R  +  L  + +    ++++ +V    L  
Sbjct: 2562 --NKELENKYAKLEEKLKESEEANEDL---RRSFNALQEEKQDLSKEIESLKVSISQLTR 2616

Query: 611  EHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQL------A 664
            +  A QE+           L H  LK K + V +L    S  +  +++L  +L      A
Sbjct: 2617 QVTALQEE-------GTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEA 2669

Query: 665  KKKQSETKLQEELNKVLGIKHFD 687
             KK  E  ++++L K L   H D
Sbjct: 2670 AKKVGE--IEDKLKKELKHLHHD 2690



 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 149/732 (20%), Positives = 294/732 (40%), Gaps = 71/732 (9%)

Query: 25   DVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKN--- 81
            D+   E+ +     QK            ++ + K+T + +      S   K E ++    
Sbjct: 1109 DLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILA 1168

Query: 82   -DKDLKILEKEIRVLLQERGAQDRRIQD----LETELEKMEARLNAALREKTSLSANNAT 136
             +K+ + L+K+++  L  R A  ++ Q+    L  EL++ +   N    +    S  N  
Sbjct: 1169 LEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENEN 1228

Query: 137  LEKQLIELT-RTNELLKSKFSENGNQKNLRIL-SLELMKLRNKRETKMRGMMAKQEGMEM 194
            +  QL +L  +  E +  K      Q++      LE    +   +   + ++      + 
Sbjct: 1229 IGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDW 1288

Query: 195  KLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEK----SETEKLLEYIEEISCASDQVEK 250
                   S  +    +AQ++ +L  IE EK++ +    S T +L +  EE+    +Q+ K
Sbjct: 1289 PSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINK 1348

Query: 251  YKLDIAQLEENLKEKNDEILSLKQSLEENIVILS--KQVEDLNVKCQLLEK---EKEDHV 305
              L+I  L+    E      SL+Q LE + + ++  + + +L  K   L+K   +KE+ V
Sbjct: 1349 QGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDV 1408

Query: 306  NRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQ 365
            +          A +  ++ + I+EQ++  K    +L++ +  ++  E    L  +LC  +
Sbjct: 1409 SYLSGQLSEKEAALTKIQTE-IIEQEDLIKALHTQLEMQA--KEHDERIKQLQVELCEMK 1465

Query: 366  EEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLE---EKLK 422
            ++         EE+ +      ++Q+K + A    K+  +E KS  EEL L     E+L 
Sbjct: 1466 QK--------PEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLT 1517

Query: 423  GKEAELEKSSAAHTQAT-------LLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLK 475
               A++E   +A  +          LLQE+ D ++  ++    + +S     +S  E LK
Sbjct: 1518 KSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSL----SSSCESLK 1573

Query: 476  LENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIK----EIT 531
            L    L E   K  K  E ++   +A  +  QE        + K   KE EI     E  
Sbjct: 1574 LALEGLTEDKEKLVKEIESLKSSKIAESTEWQE--------KHKELQKEYEILLQSYENV 1625

Query: 532  VSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKT 591
             +  ++I  +   ++Q++++   +L   E  K E E    E  +E+ + +   E++    
Sbjct: 1626 SNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMK---EKMRKFA 1682

Query: 592  KPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQ 651
            K  Q ++   E E   L  E   A +   +  ++             +     +K+E  +
Sbjct: 1683 KSKQQKILELEEENDRLRAEVHPAGDTAKECMETL------------LSSNASMKEELER 1730

Query: 652  LKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNT 711
            +K E   L  +       +  L EE+  +      + SK  + E+ E    +T + E  T
Sbjct: 1731 VKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGT 1790

Query: 712  NCYRAPMECQES 723
                   E Q+S
Sbjct: 1791 QSIPGETEEQDS 1802



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 122/607 (20%), Positives = 251/607 (41%), Gaps = 60/607 (9%)

Query: 26   VKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDL 85
            VK  EV +    F  SQ+   + E ++ + V K+     +A+KV   E K +     K+L
Sbjct: 2636 VKEEEVHRLSALFSSSQKRIAELE-EELVCVQKE-----AAKKVGEIEDKLK-----KEL 2684

Query: 86   KILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELT 145
            K L  +  ++  E    + R+ +L  +L +ME +L    +E   L+A   +  + +  L 
Sbjct: 2685 KHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQ 2744

Query: 146  RTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEE 205
             + +    +  E   + +          L+   + K +G++ ++   +  L  T  S+  
Sbjct: 2745 NSRDHANEELDELKRKYDA--------SLKELAQLKEQGLLNRER--DALLSETAFSMNS 2794

Query: 206  SQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEK 265
            ++      E  L  +EK      S+ E+LL    ++  + +QV+ +   +A L+      
Sbjct: 2795 TE------ENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHL 2848

Query: 266  NDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQK 325
             +E+   ++S EE     + Q      + Q L+K      N      + L  E++NL+Q+
Sbjct: 2849 WNELEKFRKS-EEGKQRSAAQPSTSPAEVQSLKKAMSSLQN----DRDRLLKELKNLQQQ 2903

Query: 326  FILEQQEREKLQQKELQIDSLLQQEKE---LSSSLHQKLCSFQEEMVK---EKNLFE-EE 378
            ++   QE  +L   + Q+     + K    +   L Q+  S+Q E+ +   EK+ +E  E
Sbjct: 2904 YLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHE 2963

Query: 379  LKQTLDELDKLQQKEEQAERLVKQLEE--EAKSRAEELKLLEEKLKGKEAELEKSSAAH- 435
             +     L  +  K++Q   L   + E   + S+ + LK+  ++    E       + + 
Sbjct: 2964 RRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNL 3023

Query: 436  TQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAE-- 493
               T LL+ + +  ++ +     + +   +  +  +E+    +  L + +    +N +  
Sbjct: 3024 VYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHY 3083

Query: 494  -DVQHQILATESSNQEYVRMLLDL-------QTKSALKETEIKEITVSFLQKITDLQNQL 545
             D+ +     E   QE     L++       Q K+ +      E      Q  ++ Q QL
Sbjct: 3084 GDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQL 3143

Query: 546  ---KQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFE 602
               +Q+  + RK LE+E  ++   EN  +   E+I   RL + E  +   P    + +  
Sbjct: 3144 CNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIR--RLEHSEWDSSRTPI---IGSCG 3198

Query: 603  VEKQALL 609
             ++QALL
Sbjct: 3199 TQEQALL 3205



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 159/780 (20%), Positives = 314/780 (40%), Gaps = 138/780 (17%)

Query: 39  QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQE 98
           Q S   ++    KQ L  +K+  +     ++  +++++ +Q+      + EK+ R   Q 
Sbjct: 177 QSSTEMEEFVMMKQQLQ-EKEEFISTLQAQLSQTQAEQAAQQ-----VVREKDARFETQV 230

Query: 99  RGAQDRRIQ-----DLETELEKMEARLNAALREKTSLSANNAT----LEKQLIELTRTNE 149
           R  +D  +Q     D+ETE+++    L   L E        A     L+++L    + N+
Sbjct: 231 RLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQ 290

Query: 150 LLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGK 209
           +L  +  +   + N          LRN  ET+        E ME+++   + S    Q +
Sbjct: 291 ILSQQLQQMEAEHNT---------LRNTVETEREESKILLEKMELEVAERKLSFHNLQEE 341

Query: 210 I--------------AQLEGKLVSIE-KEKIDEKSETEKLLEYI---EEISCASDQVEKY 251
           +              A+LE +  ++E K K + + +T  +L      +E+  A D ++  
Sbjct: 342 MHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKD- 400

Query: 252 KLDIAQLEENLKEKNDEILSLKQS---LEENIVILSKQVEDLNVKCQLLEKEKEDHVNRN 308
                Q  + L++KN++ +   Q+   LE+ +   SK++     +  L + E     +  
Sbjct: 401 -----QNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFP 455

Query: 309 REHNENLNA----EMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLH----QK 360
             +NE   A     + +L+++ +  + E+  L    ++++ L  + ++LSS +     Q 
Sbjct: 456 DVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQN 515

Query: 361 LCSFQEEMVKEKNLFEEELKQTLDE----LDKLQQKEEQAERLVKQLEEEAKSRAEELKL 416
                +  V E ++ +   K++        D L+    Q  + +  L  E K   EE+  
Sbjct: 516 RTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAF 575

Query: 417 LEEKLKGKEAE--------------LEKSSAAHTQATLLLQE---------KYDSMVQSL 453
           L+ +L+GK AE              +E    A  +  + L++           +S + ++
Sbjct: 576 LKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAV 635

Query: 454 EDVTAQFESYKALTASEI--EDLKLENSSLQEKAAKAGKNAEDV-----------QHQIL 500
           E   A  E +++ T+ EI   D  +E  S ++   K+     D+           + QIL
Sbjct: 636 EKEQASTE-HQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQIL 694

Query: 501 ATE---SSNQEYVRMLLDLQTK-----------------------SALKETEIKEIT-VS 533
             E      QE     LD + K                       +AL E   + ++ V 
Sbjct: 695 ELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVK 754

Query: 534 FLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAE---LTEEINKWRLLYEELYNK 590
            L  +T+L+ Q+KQ E +     E E  R+ + E+ TA    LTE+I+   +  +    K
Sbjct: 755 ELSMVTELRAQVKQLEMNL---AEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVK 811

Query: 591 TKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENS 650
            +  Q +LD  +++         + Q QL         L G + ++     V +L    S
Sbjct: 812 IEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEV--LEGAERVRHISSKVEELSQALS 869

Query: 651 QLKSEVSKLRCQLAKKKQSETKLQ---EELNKVLGIKHFDPSKAFHHESKENFALKTPLK 707
           Q + E++K+   L +KK+    LQ   EE ++ +    F  ++     ++E F+L   +K
Sbjct: 870 QKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIK 929



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 121/569 (21%), Positives = 246/569 (43%), Gaps = 98/569 (17%)

Query: 83  KDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLI 142
           KD+++ +K+   L +ER A D +I+ L     K+ A+                       
Sbjct: 71  KDVQLQQKD-EALQEERKAADNKIKKL-----KLHAKA---------------------- 102

Query: 143 ELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRS 202
           +LT  N+ ++   ++ G        S E +   +K  T+           EM+++  +  
Sbjct: 103 KLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEE----------EMEIEKIKHK 152

Query: 203 LEESQGKIAQLEGKLVSIEKEKIDEKSE--------TEKLLEYIEEISCASDQVEKYKLD 254
           L+E +  I+ L+ +L   + E+  + S          ++L E  E IS    Q+ + + +
Sbjct: 153 LQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAE 212

Query: 255 IAQLEENLKEKNDEILSLKQSLEENIVILSKQVE---DLNVKCQLLEKEKEDHVNRNREH 311
            A  ++ ++EK+    +  +  E+ ++ L  Q +   ++  K ++L+++ E       EH
Sbjct: 213 QA-AQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLE-------EH 264

Query: 312 NENL--NAEMQNLKQKFILEQQER-----EKLQQKELQIDSL---LQQEKELSSSLHQKL 361
            E+L   A++ +L Q+ +   ++R     ++LQQ E + ++L   ++ E+E S  L +K+
Sbjct: 265 EESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKM 324

Query: 362 CSFQEEMVKEKNL----FEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLL 417
               E  V E+ L     +EE+   L++ ++  Q + + E     LE++ K+  EE    
Sbjct: 325 ----ELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSH 380

Query: 418 EEKLKGKEAELEKS-SAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKL 476
              L+    EL+ +  A   Q + LLQ+K +  VQS + +  Q E      + EI    L
Sbjct: 381 ILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTI-QQLEDQLQQKSKEISQF-L 438

Query: 477 ENSSLQEKAAKAGKNAEDVQHQ--ILATESSNQEYVRMLLDLQTK------SALKETEIK 528
               LQ+    +  +  DV ++     TE +     + +++L+ +      S+++  E+K
Sbjct: 439 NRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELK 498

Query: 529 EITVSFLQKITDLQNQLKQQEED------------FRKQLEDEEGRKAEKENTTAELTEE 576
                   +IT L+ Q +  E D             ++    EE  +   ENT ++  +E
Sbjct: 499 AENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKE 558

Query: 577 INKWRLLYEELYNKTKPFQLQLDAFEVEK 605
           ++   L  +E   +    +LQL     E+
Sbjct: 559 LSVLLLEMKEAQEEIAFLKLQLQGKRAEE 587



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 83/418 (19%), Positives = 182/418 (43%), Gaps = 24/418 (5%)

Query: 302 EDHVNRNREHNENLNAEMQNL-KQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 360
           ++ V     + E L  E++++ +QK +  QQ+ E LQ++    D+ +++ K  + +    
Sbjct: 47  QEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTS 106

Query: 361 LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 420
           L  + EEM  +         Q+ ++L K  +   + E  +++++ + + + E +  L+ +
Sbjct: 107 LNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQ 166

Query: 421 LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS 480
           L   +AE    S+   +  ++++++     + +  + AQ    +A  A++          
Sbjct: 167 LTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQ--------QV 218

Query: 481 LQEKAAKAGKNA---EDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQK 537
           ++EK A+        ED   Q++       E  + L  LQ K  L+E E  E  V   Q 
Sbjct: 219 VREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRK--LEEHE--ESLVGRAQV 274

Query: 538 ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK--WRLLYEELYNKTKPFQ 595
           +  LQ +L   E+  R Q+  ++ ++ E E+ T   T E  +   ++L E++  +    +
Sbjct: 275 VDLLQQELTAAEQ--RNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERK 332

Query: 596 LQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKL--LGHQNLKQKIKHVVKLKDENSQLK 653
           L     + E   LL +   A +   ++   Y+ L       +++K  H++ L+    +L+
Sbjct: 333 LSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQ 392

Query: 654 SEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNT 711
           S    L+ Q +K  Q   K ++ +     I+  +       +    F  + PL++  T
Sbjct: 393 SACDALKDQNSKLLQD--KNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHET 448


>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
            [Homo sapiens]
          Length = 1354

 Score =  116 bits (290), Expect = 8e-26
 Identities = 158/673 (23%), Positives = 300/673 (44%), Gaps = 94/673 (13%)

Query: 75   KKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEK----MEARLNAALRE---- 126
            K E ++  +   I   +I   L E G Q R ++   +++EK    ++ R+N   R+    
Sbjct: 446  KDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQE 505

Query: 127  ---KTSLSANNATLEKQLIEL---TRTNELLKSKFSENGNQKN-----LRILSLELMKLR 175
               + ++    +TL+ QL +L   ++ ++L   K S+   Q       LR  S   ++LR
Sbjct: 506  NEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLR 565

Query: 176  NKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSI-EKEKIDEKSETEKL 234
             K  T+M   +++ E +  +LQ   R LE S+ +  +   +L +I E E+ D   ++E +
Sbjct: 566  -KSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMI 624

Query: 235  LEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKC 294
             +    I+   ++V+  K ++ ++E   KE  D +L+  +  + N+ I      DLN K 
Sbjct: 625  GDLQARITSLQEEVKHLKHNLEKVEGERKEAQD-MLNHSEKEKNNLEI------DLNYKL 677

Query: 295  QLLEKEKEDHVNRNREHNENLNAEMQNLKQ-----------KFILEQQEREKLQQKELQI 343
            + L++  E  VN ++     L  + Q++++           K   E++ REK + + +QI
Sbjct: 678  KSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQI 737

Query: 344  D---SLLQQEKELSSSLHQKLCSFQEEMVKE-KNL-------------FEEELKQTLDEL 386
            +   S+L  + + S    + L   +E M  E KNL              + ELK    E 
Sbjct: 738  EKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEA 797

Query: 387  DKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKY 446
            D L+  E+Q ++ +  L E  +    EL  L ++ +G E ++ +      +A       Y
Sbjct: 798  DNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQM-RELQDQLEAEQYFSTLY 856

Query: 447  DSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSN 506
             + V+ L++   + E        +I++L+ E  +L  +   A   AE  Q   LA     
Sbjct: 857  KTQVKELKE---EIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQ---LARGLLE 910

Query: 507  QEYVRMLLDLQTKSALKETEI--KEITVSFLQKIT-----DLQNQLKQQEEDFRKQLEDE 559
            ++Y  +  + +  ++    EI  K+ TVS L++       D++   ++ EE   K  + E
Sbjct: 911  EQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKAE 970

Query: 560  EGRKAEKE----NTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQAL------- 608
            E  K EKE    N  A   + IN  R L  +  NK      + D F+++++         
Sbjct: 971  EEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKD-FKIDRKKANTQDLRK 1029

Query: 609  -LNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEV---SKLRCQLA 664
               E+   Q +LN+ R+ + +++        +KH  +L D  +QL  E    ++L+ QLA
Sbjct: 1030 KEKENRKLQLELNQEREKFNQMV--------VKHQKELNDMQAQLVEECAHRNELQMQLA 1081

Query: 665  KKKQSETKLQEEL 677
             K+    +L+ +L
Sbjct: 1082 SKESDIEQLRAKL 1094



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 75/340 (22%), Positives = 153/340 (45%), Gaps = 42/340 (12%)

Query: 363 SFQEEMVKEKNLFEEELKQTLDELDKLQQK----EEQAERLVKQLEEEAKSRAEELKLLE 418
           S QE + K     EE+L   +   D+++QK      + ++++K+L+EE   R        
Sbjct: 423 SLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQR-------- 474

Query: 419 EKLKGKEAELEKSSAAHTQATLLLQEK---YDSMVQSLEDVTAQFESYKALTASEIEDLK 475
             L+   +++EK         +LLQ +   Y    +   +     E+  +    ++EDLK
Sbjct: 475 RNLESTVSQIEKEK-------MLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLK 527

Query: 476 --LENSSL-QEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITV 532
              +NS L  EK ++  K  E+  + +L TES     +R      +KS    ++++ +  
Sbjct: 528 KVSQNSQLANEKLSQLQKQLEEA-NDLLRTESDTAVRLRKSHTEMSKSI---SQLESLNR 583

Query: 533 SFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTK 592
              ++   L+N   Q ++D+ +     E  + ++ +     +E I   +     L  + K
Sbjct: 584 ELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHD----SEMIGDLQARITSLQEEVK 639

Query: 593 PFQLQLDAFEVEK---QALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKI-KHVV---KL 645
             +  L+  E E+   Q +LN H   ++   +I  +Y      Q L+Q++ +H V   +L
Sbjct: 640 HLKHNLEKVEGERKEAQDMLN-HSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARL 698

Query: 646 KDENSQLKSEVSKLRCQLAKKKQSETKLQEEL-NKVLGIK 684
            D++  ++   S   C++ KK + E + +E+  N+V+ I+
Sbjct: 699 TDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIE 738



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 49/241 (20%), Positives = 113/241 (46%), Gaps = 9/241 (3%)

Query: 90   KEIRVLLQERGAQD-RRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN 148
            KE++  ++E+  ++ ++IQ+L+ E E +  +L+ A  +  S       LE+Q  ELT+ +
Sbjct: 861  KELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQES 920

Query: 149  ELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG 208
            +   S+  +    K+  +  LE       ++ +    + ++E  E+  ++ +   E    
Sbjct: 921  KKAASRNRQEITDKDHTVSRLEEANSMLTKDIE----ILRRENEELTEKMKKAEEEYKLE 976

Query: 209  KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASD-QVEKYKLDIAQLEENLKEKND 267
            K  ++     + EK    E++   + +  + EI    D ++++ K +   L +  KE   
Sbjct: 977  KEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRK 1036

Query: 268  EILSLKQSLEE-NIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKF 326
              L L Q  E+ N +++  Q E  +++ QL+E+    H N  +    +  ++++ L+ K 
Sbjct: 1037 LQLELNQEREKFNQMVVKHQKELNDMQAQLVEECA--HRNELQMQLASKESDIEQLRAKL 1094

Query: 327  I 327
            +
Sbjct: 1095 L 1095


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  116 bits (290), Expect = 8e-26
 Identities = 137/564 (24%), Positives = 266/564 (47%), Gaps = 86/564 (15%)

Query: 172  MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 229
            MKL  K +  ++    ++E   MK   Q  +  L +S+ K  +LE K+V++ KEK D + 
Sbjct: 836  MKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL 895

Query: 230  ETEKLLEYIEEISCASDQVEKYKL-------DIAQLEENLKEKNDEILSLKQSLEENIVI 282
            + +   E + +     DQ+ K K+       ++ +  E+ +E N E+ + K+ LE+    
Sbjct: 896  QVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 955

Query: 283  LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK--- 339
            L K ++DL +    +EKEK  H   N+   +NL  EM  L +      +E++ LQ+    
Sbjct: 956  LKKDIDDLELTLAKVEKEK--HATENKV--KNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1011

Query: 340  ----------------------ELQIDSL---LQQEKELSSSLHQK-------LCSFQEE 367
                                  E Q+D L   L+QEK+L   L +        L   QE 
Sbjct: 1012 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071

Query: 368  MV---KEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGK 424
            ++    EK   +E+LK+   E+  LQ K E  + L  QL+++ K     ++ LEE+++ +
Sbjct: 1072 IMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAE 1131

Query: 425  EAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLK--LENSSLQ 482
             A   K+    +  +  L+E  + + ++    +AQ E  K   A E + ++  LE ++LQ
Sbjct: 1132 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA-EFQKMRRDLEEATLQ 1190

Query: 483  EKAAKA---GKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKIT 539
             +A  A    K+A+ V    L  +  N + V+  L+ + KS +K  EI ++  S ++ ++
Sbjct: 1191 HEATAATLRKKHADSVAE--LGEQIDNLQRVKQKLE-KEKSEMK-MEIDDL-ASNVETVS 1245

Query: 540  DLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLD 599
              +  L++       QL + + ++ E++    +LT +  +       L  ++  F  QLD
Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGR-------LQTESGEFSRQLD 1298

Query: 600  AFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL----KSE 655
                EK+AL++       QL++ + ++ + +  + LK++++  +K K+  +      + +
Sbjct: 1299 ----EKEALVS-------QLSRGKQAFTQQI--EELKRQLEEEIKAKNALAHALQSSRHD 1345

Query: 656  VSKLRCQLAKKKQSETKLQEELNK 679
               LR Q  ++++S+ +LQ  L+K
Sbjct: 1346 CDLLREQYEEEQESKAELQRALSK 1369



 Score =  106 bits (264), Expect = 9e-23
 Identities = 153/705 (21%), Positives = 314/705 (44%), Gaps = 93/705 (13%)

Query: 42   QRFKQQKE---SKQNLNVDKDTTLPASARKVKSSESKKESQKNDK--DLKILEKEIRVLL 96
            QR KQ+ E   S+  + +D   +   +  K K +  K      D+  +LK  E+E + L+
Sbjct: 1217 QRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLI 1276

Query: 97   QERGAQDRRIQ----DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN---- 148
             +  AQ  R+Q    +   +L++ EA ++   R K + +     L++QL E  +      
Sbjct: 1277 NDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALA 1336

Query: 149  ----------ELLKSKFSENGN-----QKNLRILSLELMKLRNKRETKMRGMMAKQEGME 193
                      +LL+ ++ E        Q+ L   + E+ + R K ET    +   +E  E
Sbjct: 1337 HALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETD--AIQRTEELEE 1394

Query: 194  MKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 253
             K ++ QR L+ ++  +  +  K  S+EK K   ++E E L+  +E  + A   ++K + 
Sbjct: 1395 AKKKLAQR-LQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQR 1453

Query: 254  DIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNE 313
            +  ++    K+K +E  +  ++ ++    L  ++     K +   +E  D +   +  N+
Sbjct: 1454 NFDKILAEWKQKCEETHAELEASQKEARSLGTEL----FKIKNAYEESLDQLETLKRENK 1509

Query: 314  NLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKN 373
            NL  E+ +L ++     +   +L++ + Q++   Q++ EL ++L +   S + E  K   
Sbjct: 1510 NLQQEISDLTEQIAEGGKRIHELEKIKKQVE---QEKCELQAALEEAEASLEHEEGKILR 1566

Query: 374  LFEEELKQTLDELD-KLQQKEEQAERLVKQ-----------LEEEAKSRAEELKLLEEKL 421
            + + EL Q   E+D K+ +K+E+ ++L +            L+ E +SR + ++L ++K+
Sbjct: 1567 I-QLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRL-KKKM 1624

Query: 422  KG--KEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENS 479
            +G   E E++ + A    A  L    Y +    L+D     +   AL + E  DLK + +
Sbjct: 1625 EGDLNEMEIQLNHANRMAAEAL--RNYRNTQGILKDTQIHLDD--ALRSQE--DLKEQLA 1678

Query: 480  SLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKIT 539
             ++ +A       E+++  +  TE S +   + LLD   +  L  T+   +  +  +  T
Sbjct: 1679 MVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLET 1738

Query: 540  DLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK-------WRLLYEELYNKTK 592
            D+ +Q++ + ED  ++  + E +  +     A + EE+ K          + + +    K
Sbjct: 1739 DI-SQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVK 1797

Query: 593  PFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQK---------IKHVV 643
              QL+LD  E E+ AL       ++Q+ K+     +L G    +QK          KH  
Sbjct: 1798 DLQLRLD--EAEQLAL----KGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHER 1851

Query: 644  KLKDENSQ----------LKSEVSKLRCQLAKKKQSETKLQEELN 678
            ++K+   Q          L+  V KL+ ++   K+   + +E+ N
Sbjct: 1852 RVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSN 1896



 Score =  105 bits (263), Expect = 1e-22
 Identities = 139/665 (20%), Positives = 285/665 (42%), Gaps = 62/665 (9%)

Query: 68   KVKSSESKKESQKNDKDLKILEKEI----RVLLQERGAQDRRIQDLETELEKMEARLNAA 123
            K++     KE  +  +D + +  E+    R L  E     + I DLE  L K+E   +A 
Sbjct: 918  KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 977

Query: 124  LREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMR 183
              +  +L+   A L++ + +LT+  + L     +  +Q+ L  L  E  K+    + K++
Sbjct: 978  ENKVKNLTEEMAGLDETIAKLTKEKKAL-----QEAHQQTLDDLQAEEDKVNTLTKAKIK 1032

Query: 184  ---------GMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKL 234
                     G + +++ + M L+  +R L E   K+AQ     +  EK+++DEK + ++ 
Sbjct: 1033 LEQQVDDLEGSLEQEKKLRMDLERAKRKL-EGDLKLAQESIMDIENEKQQLDEKLKKKEF 1091

Query: 235  LEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLE---ENIVILSKQVEDLN 291
                 EIS    ++E  +    QL++ +KE    I  L++ +E    +     KQ  DL+
Sbjct: 1092 -----EISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1146

Query: 292  VKCQLLEKEKED---HVNRNREHNENLNAEMQNLKQKF------------ILEQQEREKL 336
             + + + +  E+     +   E N+   AE Q +++               L ++  + +
Sbjct: 1147 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1206

Query: 337  QQKELQIDSL------LQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQ 390
             +   QID+L      L++EK         L S  E + K K   E+  +   D+L +L+
Sbjct: 1207 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELK 1266

Query: 391  QKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEA---ELEKSSAAHTQATLLLQEKYD 447
             KEE+ +RL+  L  +      E      +L  KEA   +L +   A TQ    L+ + +
Sbjct: 1267 SKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLE 1326

Query: 448  SMVQSLEDVTAQFESYK---ALTASEIEDLKLENSSLQEKAAKAGKNAED--VQHQILAT 502
              +++   +    +S +    L   + E+ +   + LQ   +KA         +++  A 
Sbjct: 1327 EEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAI 1386

Query: 503  ESSNQ-EYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEG 561
            + + + E  +  L  + ++A +  E      + L+K    + +L+ + ED    +E    
Sbjct: 1387 QRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEK---TKQRLQNEVEDLMLDVERTNA 1443

Query: 562  RKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNK 621
              A  +       + + +W+   EE + + +  Q +  +   E   + N +  + +QL  
Sbjct: 1444 ACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLET 1503

Query: 622  IRDSYAKLLGH-QNLKQKIKHVVKLKDENSQLKSEVSKLRCQL-AKKKQSETKLQEELNK 679
            ++     L     +L ++I    K   E  ++K +V + +C+L A  +++E  L+ E  K
Sbjct: 1504 LKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGK 1563

Query: 680  VLGIK 684
            +L I+
Sbjct: 1564 ILRIQ 1568



 Score =  104 bits (259), Expect = 3e-22
 Identities = 140/696 (20%), Positives = 295/696 (42%), Gaps = 91/696 (13%)

Query: 45   KQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDR 104
            +Q+K+ + +L   K   L    +  + S    E++K   D K+ +KE  +   +   +D 
Sbjct: 1045 EQEKKLRMDLERAK-RKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDE 1103

Query: 105  RIQ--DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQK 162
            +     L+ ++++++AR+     E  +  A+ A  EKQ  +L+R  E +  +  E G   
Sbjct: 1104 QALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT 1163

Query: 163  NLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG--------KIAQLE 214
            + +I      ++  KRE + + M    E   ++ + T  +L +           +I  L+
Sbjct: 1164 SAQI------EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQ 1217

Query: 215  GKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQ 274
                 +EKEK + K E + L   +E +S A   +EK            +   D++  LK 
Sbjct: 1218 RVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKM----------CRTLEDQLSELKS 1267

Query: 275  SLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQERE 334
              EE      + + DL  +   L+ E  +  +R  +  E L +++   KQ F  + +E +
Sbjct: 1268 KEEEQ----QRLINDLTAQRGRLQTESGEF-SRQLDEKEALVSQLSRGKQAFTQQIEELK 1322

Query: 335  KLQQKELQIDSLL------------------QQEKELSSSLHQKLCSFQEEMVKEKNLFE 376
            +  ++E++  + L                  ++E+E  + L + L     E+ + +  +E
Sbjct: 1323 RQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYE 1382

Query: 377  EELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHT 436
             +  Q  +EL++ ++K  Q  +  ++  E   ++   L+  +++L+ +  +L        
Sbjct: 1383 TDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTN 1442

Query: 437  QATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQ 496
             A   L +K     ++ + + A+++     T +E+E  + E  SL  +  K     E+  
Sbjct: 1443 AACAALDKKQ----RNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESL 1498

Query: 497  HQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQL 556
             Q+   +  N+   + + DL  + A     I E+     +++   + +L+   E+    L
Sbjct: 1499 DQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE-KIKKQVEQEKCELQAALEEAEASL 1557

Query: 557  EDEEGR-----------KAEKENTTAELTEEINKWR------------LLYEELYNKTKP 593
            E EEG+           K+E +   AE  EEI++ +             L  E+ ++   
Sbjct: 1558 EHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDA 1617

Query: 594  FQLQL----DAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQ-NLKQKIKHVVKLKDE 648
             +L+     D  E+E Q L + +  A E L   R++   L   Q +L   ++    LK++
Sbjct: 1618 IRLKKKMEGDLNEMEIQ-LNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQ 1676

Query: 649  NSQ-------LKSEVSKLRCQLAKKKQSETKLQEEL 677
             +        L++E+ +LR  L + ++S    ++EL
Sbjct: 1677 LAMVERRANLLQAEIEELRATLEQTERSRKIAEQEL 1712



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 93/435 (21%), Positives = 189/435 (43%), Gaps = 54/435 (12%)

Query: 22   GAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTL--PASARKVKSSESKKESQ 79
            G   +  LE +K  V  +K +     +E++ +L  ++   L       +VKS   +K ++
Sbjct: 1525 GGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAE 1584

Query: 80   KNDKDLKILEKEIRVLLQERGAQDRRIQD----------LETELEKMEARLNAALREKTS 129
            K+++  ++    IR++   +   D  I+           +E +L +ME +LN A R    
Sbjct: 1585 KDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAE 1644

Query: 130  LSANNATLEK-------QLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRE-TK 181
               N    +         L +  R+ E LK + +    + NL  L  E+ +LR   E T+
Sbjct: 1645 ALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANL--LQAEIEELRATLEQTE 1702

Query: 182  MRGMMAKQEGMEMKLQV------------TQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 229
                +A+QE ++   +V            T++ LE     I+Q++G++  I +E    ++
Sbjct: 1703 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD---ISQMQGEMEDILQEA---RN 1756

Query: 230  ETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVIL----SK 285
              EK  + I + +  +++++K +   A LE   K     +  L+  L+E   +      K
Sbjct: 1757 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK 1816

Query: 286  QVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDS 345
            Q++ L  + + LE E E    RN E  + L    + +K+     +++R+ + + +  +D 
Sbjct: 1817 QIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDK 1876

Query: 346  LLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEE 405
            L  + K              EE  ++ N    + ++   EL++ +++ + AE  V +L  
Sbjct: 1877 LQAKVKSYKRQ--------AEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKL-- 1926

Query: 406  EAKSRAEELKLLEEK 420
              KSR    K++ E+
Sbjct: 1927 RVKSREVHTKVISEE 1941



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 95/441 (21%), Positives = 197/441 (44%), Gaps = 70/441 (15%)

Query: 68   KVKSS--ESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLET---ELEKMEARLNA 122
            K+K++  ES  + +   ++ K L++EI  L ++     +RI +LE    ++E+ +  L A
Sbjct: 1489 KIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQA 1548

Query: 123  ALRE-KTSLSANNATLEKQLIELTRTNELLKSKFSENGNQ----KNLRILSLELMKLRNK 177
            AL E + SL      + +  +EL +    +  K +E   +    K   I  +E M+    
Sbjct: 1549 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLD 1608

Query: 178  RETKMRG----MMAKQEG--MEMKLQV-----------------------TQRSLEESQG 208
             E + R     +  K EG   EM++Q+                       TQ  L+++  
Sbjct: 1609 AEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALR 1668

Query: 209  KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDE 268
                L+ +L  +E+     ++E E+L   +E+   +    E+  LD ++  + L  +N  
Sbjct: 1669 SQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1728

Query: 269  ILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE----------DHVNRNREHNENLNAE 318
            +++ K+ LE +I  +  ++ED+  + +  E++ +          + + + ++ + +L   
Sbjct: 1729 LINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1788

Query: 319  MQNLKQ-----KFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQ---------KLCSF 364
             +N++Q     +  L++ E+  L+  + QI  L  + +EL   +           K    
Sbjct: 1789 KKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRK 1848

Query: 365  QEEMVKEKNLFEEELKQTL----DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 420
             E  VKE     EE ++ +    D +DKLQ K +  +R  ++ EE++ +   + + L+ +
Sbjct: 1849 HERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHE 1908

Query: 421  LKGKEAELEKSSAAHTQATLL 441
            L  +EAE E++  A +Q   L
Sbjct: 1909 L--EEAE-ERADIAESQVNKL 1926


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  116 bits (290), Expect = 8e-26
 Identities = 137/564 (24%), Positives = 266/564 (47%), Gaps = 86/564 (15%)

Query: 172  MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 229
            MKL  K +  ++    ++E   MK   Q  +  L +S+ K  +LE K+V++ KEK D + 
Sbjct: 836  MKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL 895

Query: 230  ETEKLLEYIEEISCASDQVEKYKL-------DIAQLEENLKEKNDEILSLKQSLEENIVI 282
            + +   E + +     DQ+ K K+       ++ +  E+ +E N E+ + K+ LE+    
Sbjct: 896  QVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 955

Query: 283  LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK--- 339
            L K ++DL +    +EKEK  H   N+   +NL  EM  L +      +E++ LQ+    
Sbjct: 956  LKKDIDDLELTLAKVEKEK--HATENKV--KNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1011

Query: 340  ----------------------ELQIDSL---LQQEKELSSSLHQK-------LCSFQEE 367
                                  E Q+D L   L+QEK+L   L +        L   QE 
Sbjct: 1012 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071

Query: 368  MV---KEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGK 424
            ++    EK   +E+LK+   E+  LQ K E  + L  QL+++ K     ++ LEE+++ +
Sbjct: 1072 IMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAE 1131

Query: 425  EAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLK--LENSSLQ 482
             A   K+    +  +  L+E  + + ++    +AQ E  K   A E + ++  LE ++LQ
Sbjct: 1132 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA-EFQKMRRDLEEATLQ 1190

Query: 483  EKAAKA---GKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKIT 539
             +A  A    K+A+ V    L  +  N + V+  L+ + KS +K  EI ++  S ++ ++
Sbjct: 1191 HEATAATLRKKHADSVAE--LGEQIDNLQRVKQKLE-KEKSEMK-MEIDDL-ASNVETVS 1245

Query: 540  DLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLD 599
              +  L++       QL + + ++ E++    +LT +  +       L  ++  F  QLD
Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGR-------LQTESGEFSRQLD 1298

Query: 600  AFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL----KSE 655
                EK+AL++       QL++ + ++ + +  + LK++++  +K K+  +      + +
Sbjct: 1299 ----EKEALVS-------QLSRGKQAFTQQI--EELKRQLEEEIKAKNALAHALQSSRHD 1345

Query: 656  VSKLRCQLAKKKQSETKLQEELNK 679
               LR Q  ++++S+ +LQ  L+K
Sbjct: 1346 CDLLREQYEEEQESKAELQRALSK 1369



 Score =  106 bits (264), Expect = 9e-23
 Identities = 153/705 (21%), Positives = 314/705 (44%), Gaps = 93/705 (13%)

Query: 42   QRFKQQKE---SKQNLNVDKDTTLPASARKVKSSESKKESQKNDK--DLKILEKEIRVLL 96
            QR KQ+ E   S+  + +D   +   +  K K +  K      D+  +LK  E+E + L+
Sbjct: 1217 QRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLI 1276

Query: 97   QERGAQDRRIQ----DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN---- 148
             +  AQ  R+Q    +   +L++ EA ++   R K + +     L++QL E  +      
Sbjct: 1277 NDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALA 1336

Query: 149  ----------ELLKSKFSENGN-----QKNLRILSLELMKLRNKRETKMRGMMAKQEGME 193
                      +LL+ ++ E        Q+ L   + E+ + R K ET    +   +E  E
Sbjct: 1337 HALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETD--AIQRTEELEE 1394

Query: 194  MKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 253
             K ++ QR L+ ++  +  +  K  S+EK K   ++E E L+  +E  + A   ++K + 
Sbjct: 1395 AKKKLAQR-LQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQR 1453

Query: 254  DIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNE 313
            +  ++    K+K +E  +  ++ ++    L  ++     K +   +E  D +   +  N+
Sbjct: 1454 NFDKILAEWKQKCEETHAELEASQKEARSLGTEL----FKIKNAYEESLDQLETLKRENK 1509

Query: 314  NLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKN 373
            NL  E+ +L ++     +   +L++ + Q++   Q++ EL ++L +   S + E  K   
Sbjct: 1510 NLQQEISDLTEQIAEGGKRIHELEKIKKQVE---QEKCELQAALEEAEASLEHEEGKILR 1566

Query: 374  LFEEELKQTLDELD-KLQQKEEQAERLVKQ-----------LEEEAKSRAEELKLLEEKL 421
            + + EL Q   E+D K+ +K+E+ ++L +            L+ E +SR + ++L ++K+
Sbjct: 1567 I-QLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRL-KKKM 1624

Query: 422  KG--KEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENS 479
            +G   E E++ + A    A  L    Y +    L+D     +   AL + E  DLK + +
Sbjct: 1625 EGDLNEMEIQLNHANRMAAEAL--RNYRNTQGILKDTQIHLDD--ALRSQE--DLKEQLA 1678

Query: 480  SLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKIT 539
             ++ +A       E+++  +  TE S +   + LLD   +  L  T+   +  +  +  T
Sbjct: 1679 MVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLET 1738

Query: 540  DLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK-------WRLLYEELYNKTK 592
            D+ +Q++ + ED  ++  + E +  +     A + EE+ K          + + +    K
Sbjct: 1739 DI-SQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVK 1797

Query: 593  PFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQK---------IKHVV 643
              QL+LD  E E+ AL       ++Q+ K+     +L G    +QK          KH  
Sbjct: 1798 DLQLRLD--EAEQLAL----KGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHER 1851

Query: 644  KLKDENSQ----------LKSEVSKLRCQLAKKKQSETKLQEELN 678
            ++K+   Q          L+  V KL+ ++   K+   + +E+ N
Sbjct: 1852 RVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSN 1896



 Score =  105 bits (263), Expect = 1e-22
 Identities = 139/665 (20%), Positives = 285/665 (42%), Gaps = 62/665 (9%)

Query: 68   KVKSSESKKESQKNDKDLKILEKEI----RVLLQERGAQDRRIQDLETELEKMEARLNAA 123
            K++     KE  +  +D + +  E+    R L  E     + I DLE  L K+E   +A 
Sbjct: 918  KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 977

Query: 124  LREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMR 183
              +  +L+   A L++ + +LT+  + L     +  +Q+ L  L  E  K+    + K++
Sbjct: 978  ENKVKNLTEEMAGLDETIAKLTKEKKAL-----QEAHQQTLDDLQAEEDKVNTLTKAKIK 1032

Query: 184  ---------GMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKL 234
                     G + +++ + M L+  +R L E   K+AQ     +  EK+++DEK + ++ 
Sbjct: 1033 LEQQVDDLEGSLEQEKKLRMDLERAKRKL-EGDLKLAQESIMDIENEKQQLDEKLKKKEF 1091

Query: 235  LEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLE---ENIVILSKQVEDLN 291
                 EIS    ++E  +    QL++ +KE    I  L++ +E    +     KQ  DL+
Sbjct: 1092 -----EISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1146

Query: 292  VKCQLLEKEKED---HVNRNREHNENLNAEMQNLKQKF------------ILEQQEREKL 336
             + + + +  E+     +   E N+   AE Q +++               L ++  + +
Sbjct: 1147 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1206

Query: 337  QQKELQIDSL------LQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQ 390
             +   QID+L      L++EK         L S  E + K K   E+  +   D+L +L+
Sbjct: 1207 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELK 1266

Query: 391  QKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEA---ELEKSSAAHTQATLLLQEKYD 447
             KEE+ +RL+  L  +      E      +L  KEA   +L +   A TQ    L+ + +
Sbjct: 1267 SKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLE 1326

Query: 448  SMVQSLEDVTAQFESYK---ALTASEIEDLKLENSSLQEKAAKAGKNAED--VQHQILAT 502
              +++   +    +S +    L   + E+ +   + LQ   +KA         +++  A 
Sbjct: 1327 EEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAI 1386

Query: 503  ESSNQ-EYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEG 561
            + + + E  +  L  + ++A +  E      + L+K    + +L+ + ED    +E    
Sbjct: 1387 QRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEK---TKQRLQNEVEDLMLDVERTNA 1443

Query: 562  RKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNK 621
              A  +       + + +W+   EE + + +  Q +  +   E   + N +  + +QL  
Sbjct: 1444 ACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLET 1503

Query: 622  IRDSYAKLLGH-QNLKQKIKHVVKLKDENSQLKSEVSKLRCQL-AKKKQSETKLQEELNK 679
            ++     L     +L ++I    K   E  ++K +V + +C+L A  +++E  L+ E  K
Sbjct: 1504 LKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGK 1563

Query: 680  VLGIK 684
            +L I+
Sbjct: 1564 ILRIQ 1568



 Score =  104 bits (259), Expect = 3e-22
 Identities = 140/696 (20%), Positives = 295/696 (42%), Gaps = 91/696 (13%)

Query: 45   KQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDR 104
            +Q+K+ + +L   K   L    +  + S    E++K   D K+ +KE  +   +   +D 
Sbjct: 1045 EQEKKLRMDLERAK-RKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDE 1103

Query: 105  RIQ--DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQK 162
            +     L+ ++++++AR+     E  +  A+ A  EKQ  +L+R  E +  +  E G   
Sbjct: 1104 QALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT 1163

Query: 163  NLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG--------KIAQLE 214
            + +I      ++  KRE + + M    E   ++ + T  +L +           +I  L+
Sbjct: 1164 SAQI------EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQ 1217

Query: 215  GKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQ 274
                 +EKEK + K E + L   +E +S A   +EK            +   D++  LK 
Sbjct: 1218 RVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKM----------CRTLEDQLSELKS 1267

Query: 275  SLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQERE 334
              EE      + + DL  +   L+ E  +  +R  +  E L +++   KQ F  + +E +
Sbjct: 1268 KEEEQ----QRLINDLTAQRGRLQTESGEF-SRQLDEKEALVSQLSRGKQAFTQQIEELK 1322

Query: 335  KLQQKELQIDSLL------------------QQEKELSSSLHQKLCSFQEEMVKEKNLFE 376
            +  ++E++  + L                  ++E+E  + L + L     E+ + +  +E
Sbjct: 1323 RQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYE 1382

Query: 377  EELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHT 436
             +  Q  +EL++ ++K  Q  +  ++  E   ++   L+  +++L+ +  +L        
Sbjct: 1383 TDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTN 1442

Query: 437  QATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQ 496
             A   L +K     ++ + + A+++     T +E+E  + E  SL  +  K     E+  
Sbjct: 1443 AACAALDKKQ----RNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESL 1498

Query: 497  HQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQL 556
             Q+   +  N+   + + DL  + A     I E+     +++   + +L+   E+    L
Sbjct: 1499 DQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE-KIKKQVEQEKCELQAALEEAEASL 1557

Query: 557  EDEEGR-----------KAEKENTTAELTEEINKWR------------LLYEELYNKTKP 593
            E EEG+           K+E +   AE  EEI++ +             L  E+ ++   
Sbjct: 1558 EHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDA 1617

Query: 594  FQLQL----DAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQ-NLKQKIKHVVKLKDE 648
             +L+     D  E+E Q L + +  A E L   R++   L   Q +L   ++    LK++
Sbjct: 1618 IRLKKKMEGDLNEMEIQ-LNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQ 1676

Query: 649  NSQ-------LKSEVSKLRCQLAKKKQSETKLQEEL 677
             +        L++E+ +LR  L + ++S    ++EL
Sbjct: 1677 LAMVERRANLLQAEIEELRATLEQTERSRKIAEQEL 1712



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 93/435 (21%), Positives = 189/435 (43%), Gaps = 54/435 (12%)

Query: 22   GAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTL--PASARKVKSSESKKESQ 79
            G   +  LE +K  V  +K +     +E++ +L  ++   L       +VKS   +K ++
Sbjct: 1525 GGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAE 1584

Query: 80   KNDKDLKILEKEIRVLLQERGAQDRRIQD----------LETELEKMEARLNAALREKTS 129
            K+++  ++    IR++   +   D  I+           +E +L +ME +LN A R    
Sbjct: 1585 KDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAE 1644

Query: 130  LSANNATLEK-------QLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRE-TK 181
               N    +         L +  R+ E LK + +    + NL  L  E+ +LR   E T+
Sbjct: 1645 ALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANL--LQAEIEELRATLEQTE 1702

Query: 182  MRGMMAKQEGMEMKLQV------------TQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 229
                +A+QE ++   +V            T++ LE     I+Q++G++  I +E    ++
Sbjct: 1703 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD---ISQMQGEMEDILQEA---RN 1756

Query: 230  ETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVIL----SK 285
              EK  + I + +  +++++K +   A LE   K     +  L+  L+E   +      K
Sbjct: 1757 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK 1816

Query: 286  QVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDS 345
            Q++ L  + + LE E E    RN E  + L    + +K+     +++R+ + + +  +D 
Sbjct: 1817 QIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDK 1876

Query: 346  LLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEE 405
            L  + K              EE  ++ N    + ++   EL++ +++ + AE  V +L  
Sbjct: 1877 LQAKVKSYKRQ--------AEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKL-- 1926

Query: 406  EAKSRAEELKLLEEK 420
              KSR    K++ E+
Sbjct: 1927 RVKSREVHTKVISEE 1941



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 95/441 (21%), Positives = 197/441 (44%), Gaps = 70/441 (15%)

Query: 68   KVKSS--ESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLET---ELEKMEARLNA 122
            K+K++  ES  + +   ++ K L++EI  L ++     +RI +LE    ++E+ +  L A
Sbjct: 1489 KIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQA 1548

Query: 123  ALRE-KTSLSANNATLEKQLIELTRTNELLKSKFSENGNQ----KNLRILSLELMKLRNK 177
            AL E + SL      + +  +EL +    +  K +E   +    K   I  +E M+    
Sbjct: 1549 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLD 1608

Query: 178  RETKMRG----MMAKQEG--MEMKLQV-----------------------TQRSLEESQG 208
             E + R     +  K EG   EM++Q+                       TQ  L+++  
Sbjct: 1609 AEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALR 1668

Query: 209  KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDE 268
                L+ +L  +E+     ++E E+L   +E+   +    E+  LD ++  + L  +N  
Sbjct: 1669 SQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1728

Query: 269  ILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE----------DHVNRNREHNENLNAE 318
            +++ K+ LE +I  +  ++ED+  + +  E++ +          + + + ++ + +L   
Sbjct: 1729 LINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1788

Query: 319  MQNLKQ-----KFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQ---------KLCSF 364
             +N++Q     +  L++ E+  L+  + QI  L  + +EL   +           K    
Sbjct: 1789 KKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRK 1848

Query: 365  QEEMVKEKNLFEEELKQTL----DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 420
             E  VKE     EE ++ +    D +DKLQ K +  +R  ++ EE++ +   + + L+ +
Sbjct: 1849 HERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHE 1908

Query: 421  LKGKEAELEKSSAAHTQATLL 441
            L  +EAE E++  A +Q   L
Sbjct: 1909 L--EEAE-ERADIAESQVNKL 1926


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score =  115 bits (288), Expect = 1e-25
 Identities = 145/664 (21%), Positives = 290/664 (43%), Gaps = 95/664 (14%)

Query: 70   KSSESKKESQKNDKDLKILEKEI---RVLLQERGAQDRRIQDLETELEKMEARLNAALR- 125
            ++ E + E    +K+ ++L+K+I   ++  ++  A ++   +LE E  K++  L++    
Sbjct: 626  RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNL 685

Query: 126  --EKTSLSANNATLEKQLIELTRTNELLKS----------KFSENGNQKNLRILSLELMK 173
              +  SL   N+ L+++ +EL R  E LK           +  E  ++K      LEL+K
Sbjct: 686  TFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLK 745

Query: 174  LRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEK 233
               K+  ++       +G++++ Q  Q++LE S  KI QLE +L  +E     E    +K
Sbjct: 746  ASFKKTERLE---VSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM----ENQTLQK 798

Query: 234  LLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVK 293
             LE ++  S   +Q+EK    + Q    L++   ++    + L +   I    +E+ NVK
Sbjct: 799  NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVK 858

Query: 294  CQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFI----LEQQEREKLQQKELQIDSLLQQ 349
               LEKE           N+ L+ E+   K+  +    LE++ +E +++  + I +L+  
Sbjct: 859  IGNLEKE-----------NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTL 907

Query: 350  EKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKS 409
             ++L S           E +K + +   +L++   EL+K+   +E      + L +E  +
Sbjct: 908  REDLVS-----------EKLKTQQM-NNDLEKLTHELEKIGLNKE------RLLHDEQST 949

Query: 410  RAEELKLLEEKLKG---KEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKAL 466
                 KLLE KL+    K  E+++   A  +A L     Y+  ++  +++    ++Y+AL
Sbjct: 950  DDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLR--QELKTVKKNYEAL 1007

Query: 467  TASEIEDLKLENS-SLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKET 525
               + E+  +++S  +  +  K  + +++   ++L  +    E  R    LQ +    +T
Sbjct: 1008 KQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKT 1067

Query: 526  EIKEI-----------------TVSFLQKITDLQNQ----------LKQQEEDFRKQLED 558
            ++K++                 TVS  ++ T LQ Q          L  Q      Q   
Sbjct: 1068 QLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQ 1127

Query: 559  EEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQ 618
               +++  EN    + +E    + LY+ L    +  +L  +    E ++L+++HG  +  
Sbjct: 1128 LLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSA 1187

Query: 619  LNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELN 678
               +   +  L    N  Q +K   +L+D    LK E  K+   L + K  ET +  E  
Sbjct: 1188 HKNLEVEHRDLEDRYN--QLLKQKGQLEDLEKMLKVEQEKM---LLENKNHET-VAAEYK 1241

Query: 679  KVLG 682
            K+ G
Sbjct: 1242 KLCG 1245



 Score =  112 bits (280), Expect = 1e-24
 Identities = 160/678 (23%), Positives = 299/678 (44%), Gaps = 90/678 (13%)

Query: 40  KSQRFKQQKESKQNLNVDKDTTLPASARKVKS---------SESKKESQKNDKDLKILEK 90
           K +R +Q+ E K    +D    L     ++K          S+++      D+   + EK
Sbjct: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREK 318

Query: 91  EIRV--LLQERGAQDRRIQDLE---TELEKMEARLNAALREKTSLS---ANNATLEKQLI 142
            +RV  L  E      R+ D+E     +E+++      L  KT L            +L 
Sbjct: 319 AVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378

Query: 143 ELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQV---- 198
           EL + N  LK+K  +   ++++     +  K+    E  M   MA+++ M+  L +    
Sbjct: 379 ELEKENLQLKAKLHDMEMERDM-----DRKKIEELMEENMTLEMAQKQSMDESLHLGWEL 433

Query: 199 -----TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 253
                T    E  Q  +     +L S    K++   E + L + +EE+    D VE    
Sbjct: 434 EQISRTSELSEAPQKSLGHEVNELTSSRLLKLE--MENQSLTKTVEELRTTVDSVEGNAS 491

Query: 254 DIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNE 313
            I ++E     K ++ LS K  + EN ++  KQ       CQ L K   D +    +  +
Sbjct: 492 KILKME-----KENQRLSKKVEILENEIVQEKQSLQ---NCQNLSK---DLMKEKAQLEK 540

Query: 314 NLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKN 373
            +    +N +++  + +QE E L Q      S L+Q  ++S+    K      ++ KE  
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTV----SSLRQRSQISAEARVK------DIEKENK 590

Query: 374 LFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSA 433
           +  E +K+T  +L K++ ++ Q ++ ++  +E+ + RAEEL+     L+ KE EL +   
Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE-RAEELENELHHLE-KENELLQKKI 648

Query: 434 AHTQATL----LLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAG 489
            + + T      L+++   + +    +    +S+K LT  ++E L+ ENS L E+  +  
Sbjct: 649 TNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLT-FQLESLEKENSQLDEENLELR 707

Query: 490 KNAEDV--------QHQILATE-SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 540
           +N E +        Q Q+   E  S +E ++  L+L  K++ K+TE  E++   L    D
Sbjct: 708 RNVESLKCASMKMAQLQLENKELESEKEQLKKGLEL-LKASFKKTERLEVSYQGL----D 762

Query: 541 LQNQ-LKQQEEDFRKQLE--DEEGRKAEKENTTAELT-EEINKWRLLYEELYNKTKPFQL 596
           ++NQ L++  E+  K+++  + E +  E EN T +   EE+       E+L  + K  + 
Sbjct: 763 IENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQ 822

Query: 597 QLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEV 656
           +    E +K+ L  E+   ++Q  +I+D+    L   N+K     +  L+ EN  L  E+
Sbjct: 823 ETSQLEKDKKQLEKENKRLRQQA-EIKDT---TLEENNVK-----IGNLEKENKTLSKEI 873

Query: 657 S--KLRCQLAKKKQSETK 672
              K  C   K+ + E K
Sbjct: 874 GIYKESCVRLKELEKENK 891



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 138/595 (23%), Positives = 263/595 (44%), Gaps = 94/595 (15%)

Query: 27   KTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESK----------- 75
            K+LE     +   K Q  K+ K  +Q   + KDTTL  +  K+ + E +           
Sbjct: 818  KSLEQETSQLEKDKKQLEKENKRLRQQAEI-KDTTLEENNVKIGNLEKENKTLSKEIGIY 876

Query: 76   -------KESQKNDKDL----KILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAAL 124
                   KE +K +K+L     I  K +  L ++  ++  + Q +  +LEK+   L    
Sbjct: 877  KESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHEL---- 932

Query: 125  REKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNK-RETKMR 183
             EK  L+      ++Q  + +R  +LL+SK  E+  +K+L I   ++  L  +  E+   
Sbjct: 933  -EKIGLNKERLLHDEQSTDDSR-YKLLESKL-ESTLKKSLEIKEEKIAALEARLEESTNY 989

Query: 184  GMMAKQEGMEMKLQVTQRSLEESQGKIAQ----LEGKLVSIEKEKIDEKSETEKLLEYIE 239
                +QE   +K         + + ++ Q    + G+    E+E  +   E  K+ + + 
Sbjct: 990  NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1049

Query: 240  EI--SCASDQVEK--YKLDIAQLEENLKEKNDEILSLKQ---SLEENIVILSKQVEDLNV 292
            E+  + A+ Q EK   K  + QLE        +IL+L++   SL+E    L  Q   L V
Sbjct: 1050 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1109

Query: 293  KCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKE 352
            +   L  +    +N+N +      + ++N  +  I E+++ + L       DSL++  ++
Sbjct: 1110 ENSTLNSQSTSLMNQNAQLLIQ-QSSLENENESVIKEREDLKSL------YDSLIKDHEK 1162

Query: 353  LSSSLHQKLCSFQEEMVKE--------KNLFEEELKQTLDELDKLQQKEEQAERLVKQLE 404
            L   LH++  S  E ++ +        KNL E E +   D  ++L +++ Q E L K L+
Sbjct: 1163 L-ELLHERQASEYESLISKHGTLKSAHKNL-EVEHRDLEDRYNQLLKQKGQLEDLEKMLK 1220

Query: 405  EEAKSRAEELKLLEEK-LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESY 463
             E     +E  LLE K  +   AE +K    + +    L   Y  +++  E +    ++ 
Sbjct: 1221 VE-----QEKMLLENKNHETVAAEYKKLCGENDR----LNHTYSQLLKETEVLQTDHKNL 1271

Query: 464  KALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQ------------EYVR 511
            K+L    + + KLE + L+ + +K  +  +  Q  I +T+ +NQ            E  R
Sbjct: 1272 KSL----LNNSKLEQTRLEAEFSKLKEQYQ--QLDITSTKLNNQCELLSQLKGNLEEENR 1325

Query: 512  MLLD------LQTKSALKET-EIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDE 559
             LLD      LQ ++ L++  E K++     ++  D  N+L++Q+E   +++ D+
Sbjct: 1326 HLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1380



 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 137/628 (21%), Positives = 264/628 (42%), Gaps = 124/628 (19%)

Query: 139 KQLIELTRTNELL--KSKFSENGNQKNLRILSLEL---MKLRNKRE--TKMRGM-MAKQE 190
           +QLI ++  N L+  K+ FSE G ++  ++L L L   ++ + K E   +++G+    + 
Sbjct: 95  QQLIMMSLPNVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKA 154

Query: 191 GMEMKLQVTQRSLEE------------SQGKIAQLEGKLVSIEKEKIDEKSE-TEKLLEY 237
            +   +Q    + E             SQ  I  L   +    K  IDE+ E +E ++E 
Sbjct: 155 AVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIEL 214

Query: 238 IEEIS---------------CASDQVEKY-------------KLDIAQLEENLKEKNDEI 269
            EE                 C S  +++              K  I +L + L+EK +++
Sbjct: 215 SEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQL 274

Query: 270 LSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILE 329
           L  KQ LE                      + E  + R ++ N NL ++ ++ +    + 
Sbjct: 275 LDCKQELE----------------------QMEIELKRLQQENMNLLSDARSAR----MY 308

Query: 330 QQEREKLQQKELQIDSLLQQEKELSSSLH---------QKLCSFQEEMVKEKNLFEEELK 380
           + E + L++K +++D L  +       LH         ++L    + +++ K + E++L+
Sbjct: 309 RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLE 368

Query: 381 QTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATL 440
            T    DKL + E++  +L  +L +    R  + K +EE L  +   LE +       +L
Sbjct: 369 GTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEE-LMEENMTLEMAQKQSMDESL 427

Query: 441 LLQEKYDSMVQSLEDVTAQFES----YKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQ 496
            L  + + + ++ E   A  +S       LT+S +  L++EN SL +   +     + V+
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVE 487

Query: 497 ---HQILATESSNQ-----------EYVRMLLDLQ-----TKSALKETEIKEITVSFLQK 537
               +IL  E  NQ           E V+    LQ     +K  +KE    E T+  L++
Sbjct: 488 GNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547

Query: 538 ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQ 597
            ++ Q ++ +QE +   Q      R+  + +  A + +   + ++L+E +    K    +
Sbjct: 548 NSERQIKILEQENEHLNQTVSSL-RQRSQISAEARVKDIEKENKILHESI----KETSSK 602

Query: 598 LDAFEVEKQAL------LNEHGAAQEQL-NKIR--DSYAKLLGHQ--NLKQKIKHVVKLK 646
           L   E EK+ +        E G   E+L N++   +   +LL  +  NLK   + +  L+
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALE 662

Query: 647 DENSQLKSEVSKLRCQLAKKKQSETKLQ 674
            ENS+L+ E  KL+  L   K    +L+
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQLE 690



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 117/507 (23%), Positives = 217/507 (42%), Gaps = 75/507 (14%)

Query: 39   QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKK---ESQKNDKDL-KILEKEIRV 94
            Q  Q  K  K++ + L   +D      +    S E  K   ESQ+  ++L K+ ++ I V
Sbjct: 992  QLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV 1051

Query: 95   ------LLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN 148
                  L  E+ A   +++ LET+   ++A++ A  R+  SL   N TL+ Q  +L   N
Sbjct: 1052 ERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVEN 1111

Query: 149  ELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG 208
              L S+ +   NQ N ++L ++   L N+ E+ ++            L+    SL +   
Sbjct: 1112 STLNSQSTSLMNQ-NAQLL-IQQSSLENENESVIK--------EREDLKSLYDSLIKDHE 1161

Query: 209  KIAQLEGKLVSIEKEKIDE----KSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKE 264
            K+  L  +  S  +  I +    KS  + L     ++    +Q+ K K  +  LE+ LK 
Sbjct: 1162 KLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKV 1221

Query: 265  KNDEILSLKQSLEENIVILSKQV----EDLNVKCQLLEKEKE----DH------VNRNRE 310
            + +++L L+    E +    K++    + LN     L KE E    DH      +N ++ 
Sbjct: 1222 EQEKML-LENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKL 1280

Query: 311  HNENLNAEMQNLKQKFILEQQEREKL-QQKEL--QIDSLLQQEKELSSSLHQKLC----S 363
                L AE   LK+++        KL  Q EL  Q+   L++E        Q L     +
Sbjct: 1281 EQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRT 1340

Query: 364  FQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKG 423
              E+ ++ K+LF  E +Q +D+L++L++++E+                     LEEK+  
Sbjct: 1341 LLEQNMESKDLFHVEQRQYIDKLNELRRQKEK---------------------LEEKIMD 1379

Query: 424  KEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIED----LKLENS 479
            +    + S        + L  K   +++S +D+  + +    LT +  +     L+L + 
Sbjct: 1380 QYKFYDPSPPRRRGNWITL--KMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQ 1437

Query: 480  SLQEKAAKAGKNAEDVQHQILATESSN 506
              Q+ ++    + ED   Q L T+ S+
Sbjct: 1438 DSQDSSSVGSNSLED--GQTLGTKKSS 1462


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  114 bits (286), Expect = 2e-25
 Identities = 142/604 (23%), Positives = 263/604 (43%), Gaps = 77/604 (12%)

Query: 47   QKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDR-- 104
            + E ++    +K+T L A  +K +  E+  E Q + +D++  ++EI+  L E   Q    
Sbjct: 649  EAEKRREALWEKNTHLEAQLQKAE--EAGAELQADLRDIQEEKEEIQKKLSESRHQQEAA 706

Query: 105  --RIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQK 162
              +++ L  E ++ E  L  A++EK +L    A LE +L  + R  + L  +     + K
Sbjct: 707  TTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAK 766

Query: 163  NLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEK 222
             L   SL   + +N      +G +      E+++Q   ++ E  QG++  L+ +L +   
Sbjct: 767  ELLESSLFEAQQQNSVIEVTKGQL------EVQIQTVTQAKEVIQGEVRCLKLELDT--- 817

Query: 223  EKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVI 282
                E+S+ E      +E   A+ Q       +AQ E+  K           +LE+    
Sbjct: 818  ----ERSQAE------QERDAAARQ-------LAQAEQEGKT----------ALEQQKAA 850

Query: 283  LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQ 342
              K+V  L  K    EKE+  H     +  E+L  E   L+ +   +Q E E +Q     
Sbjct: 851  HEKEVNQLREKW---EKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQA---- 903

Query: 343  IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQ 402
                  Q +E  +     LC  Q E  KE+    E L QT  EL    Q   Q ERL + 
Sbjct: 904  ------QREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQ---QLERLRQD 954

Query: 403  LEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFES 462
            ++ +     E   +L+ +L+  + EL++++  H      LQE+  S++Q   D+  Q E 
Sbjct: 955  MKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVED 1014

Query: 463  YKALTASEIEDLKLENSSLQEKAAKA---GKNAEDVQHQILATESSNQEYVRMLLDLQTK 519
             K+   ++ +  +L    +QEK  +     +  ++++ +  +   S  E  + LL LQ  
Sbjct: 1015 LKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEA 1074

Query: 520  SALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK 579
             ++++ E+  +    +Q+    Q +L  Q E  R++++++E     +E   A+L EE+  
Sbjct: 1075 DSIRQQELSALRQD-MQEAQGEQKELSAQMELLRQEVKEKEADFLAQE---AQLLEELEA 1130

Query: 580  WRLLYEEL-------YNKTKPFQLQLDAFEVEKQALLNE-----HGAAQEQLNKIRDSYA 627
              +  ++L         K    QL+L + E + +AL  E        AQ QL  +  +  
Sbjct: 1131 SHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQ 1190

Query: 628  KLLG 631
            + LG
Sbjct: 1191 QALG 1194



 Score =  109 bits (273), Expect = 8e-24
 Identities = 160/730 (21%), Positives = 313/730 (42%), Gaps = 89/730 (12%)

Query: 29   LEVLKGPVSFQKSQRFKQQKE--------SKQNLNVDKDTTLPASARKVKS--SESKKES 78
            +E L+G +   + QR  Q+           K+N  VD          K +S         
Sbjct: 1437 VETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAV 1496

Query: 79   QKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLE 138
            Q+ ++ L +  ++IR L ++R  Q   ++    ELEK +  + +   +   L     TLE
Sbjct: 1497 QEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLE 1556

Query: 139  KQLIELTRTNELLKSKFSE----NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEM 194
               +EL   +  ++ +        G ++  R+    L     +R  +++   ++   +E 
Sbjct: 1557 CLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLES 1616

Query: 195  KLQVTQRSLEESQGKIAQLEGKLVSIEKEKI----DEKSETEKLLEYIEEISCASDQVEK 250
               V  R L+E   ++     ++  ++++K     D +   ++L+   E I    DQ  +
Sbjct: 1617 HSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTR 1676

Query: 251  Y----KLDIAQLEENLKEKNDEILSLKQSLEENIV-----ILSKQVEDLNVKCQLLEKEK 301
                 + D+ Q++ +L+E+  E+ + +Q ++E          +++    ++K  L +KEK
Sbjct: 1677 QTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEK 1736

Query: 302  E-----DHVNRNREHNENLNAEMQNLKQKF---------------ILEQQEREKLQQKEL 341
            E     +H++  +E  + L  ++Q L +K                +L+QQ +E  +Q EL
Sbjct: 1737 EVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGEL 1796

Query: 342  QIDSLLQQEKELSSSL------------HQKLCSFQEEMVKEK-NLFEEELKQ---TLDE 385
            +  SL  Q  E   +L             Q+    QEE VKEK +  +  L+Q   TL E
Sbjct: 1797 KEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKE 1856

Query: 386  LD-KLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQE 444
               +LQ  +EQA RL ++L  E + R + L+ +   L+ +  E EK+  A  Q      +
Sbjct: 1857 RHGELQDHKEQARRLEEELAVEGR-RVQALEEVLGDLRAESREQEKALLALQQQCAEQAQ 1915

Query: 445  KYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATES 504
            +++   ++L+D   Q ++       E+E L+ E+ S + +   A   AE +Q  +    +
Sbjct: 1916 EHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHA 1975

Query: 505  SNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQ---LEDEEG 561
            + Q   + LL+     A     ++  T +    +   Q   +Q EE  R Q   ++D++ 
Sbjct: 1976 ALQGKEQHLLE----QAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDL 2031

Query: 562  RKAEK----ENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE 617
            R  E     +   A+  EE+ + +   E+L  K+   ++Q +  + EKQ L  E    +E
Sbjct: 2032 RYQEDVQQLQQALAQRDEEL-RHQQEREQLLEKSLAQRVQENMIQ-EKQNLGQER--EEE 2087

Query: 618  QLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSE-------VSKLRCQLAKKKQSE 670
            ++  +  S  +L     L QK + +++L++   +   E        S +  Q  K    E
Sbjct: 2088 EIRGLHQSVREL--QLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLE 2145

Query: 671  TKLQEELNKV 680
             +LQ EL ++
Sbjct: 2146 PRLQRELERL 2155



 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 131/639 (20%), Positives = 281/639 (43%), Gaps = 57/639 (8%)

Query: 60   TTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEAR 119
            T L A A      +  ++  K  +   +L  +++ L +     +     + TEL+ ++ +
Sbjct: 1234 TALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQ 1293

Query: 120  LNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRE 179
            L+    EK+       +LE +L+EL  T   L+S+         LR   L+ M+ + +RE
Sbjct: 1294 LSQNQEEKSKWEGKQNSLESELMELHETMASLQSR---------LRRAELQRMEAQGERE 1344

Query: 180  TKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQ---LEGKL------VSIEKEKIDEKSE 230
                 + A +E +  +++  Q ++ E++ + +    LE  L      + ++ E+++ + E
Sbjct: 1345 L----LQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERE 1400

Query: 231  TEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDL 290
              + L+   E+  A  Q +  + ++A L + L E+ +E+ +L+  ++E    L KQ E  
Sbjct: 1401 RAQALQEQGELKVA--QGKALQENLALLTQTLAEREEEVETLRGQIQE----LEKQREMQ 1454

Query: 291  NVKCQLLE---KEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLL 347
                +LL    K++   V+  +E  + L      L+   +  Q+  +KL  +  QI  L 
Sbjct: 1455 KAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELE 1514

Query: 348  QQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEA 407
            +  +   + L  +L     E+ K+  + E +  Q  D    L+++    E L  +LEE  
Sbjct: 1515 KDRETQRNVLEHQLL----ELEKKDQMIESQRGQVQD----LKKQLVTLECLALELEENH 1566

Query: 408  KSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALT 467
                 + KL++E     E + E    A T  TL L+E+   + Q+        ES+  + 
Sbjct: 1567 HKMECQQKLIKE----LEGQRETQRVALTHLTLDLEERSQEL-QAQSSQIHDLESHSTVL 1621

Query: 468  ASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESS---NQEYVRMLLDLQTK-SALK 523
            A E+++   E  S +E+  +  +  E +   +   +      +E +++L D +T+ + + 
Sbjct: 1622 ARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKIL 1681

Query: 524  ETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLL 583
            E ++++I +S  ++  +L  Q +  +E   +     + ++   E+    L ++  +    
Sbjct: 1682 EEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQ 1741

Query: 584  YEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVV 643
             E ++      Q   D  E + Q L  + G     L++       L   Q   Q+ +   
Sbjct: 1742 QEHIHE----LQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVL---QQQLQEAREQG 1794

Query: 644  KLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLG 682
            +LK+++  L+S++ + +  LA++ Q    LQ+E  +  G
Sbjct: 1795 ELKEQS--LQSQLDEAQRALAQRDQELEALQQEQQQAQG 1831



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 145/694 (20%), Positives = 303/694 (43%), Gaps = 100/694 (14%)

Query: 33   KGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEI 92
            +G    Q+ Q+   ++++     VD    + + +++ +  +  +E  +  + L++LE+E 
Sbjct: 429  EGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELR--QQLEVLEQEA 486

Query: 93   RVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLE----KQLIELTRTN 148
              L +       +    + + E+ +  L+ A+RE+  L      LE    + L EL    
Sbjct: 487  WRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLR 546

Query: 149  ELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG 208
            E L+S   E               +L  + +T++   +A+ E    +L  ++ +L+    
Sbjct: 547  EALESSHLEG--------------ELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVA 592

Query: 209  KIAQLEGKLVSI-EKEKIDEKSETEKLLEYIEEISCASDQVEK-------YKLDIAQLE- 259
             +     KL ++ E   +D+    ++LL+  EE      ++E         ++D+A+ E 
Sbjct: 593  DLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEK 652

Query: 260  --ENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNA 317
              E L EKN  + +  Q  EE    L   + D+  + + ++K+    ++ +R   E    
Sbjct: 653  RREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKK----LSESRHQQEAATT 708

Query: 318  EMQNLKQKFILEQ-------QEREKLQQKELQIDSLLQQEKELSSSLHQKL--CSFQEEM 368
            +++ L Q+   ++       QE+E L +++  ++  LQ  +     L ++L   S  +E+
Sbjct: 709  QLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKEL 768

Query: 369  VKEKNLFEEELKQTLDELDKLQ-----QKEEQAERLVK---------------QLEEEAK 408
            + E +LFE + + ++ E+ K Q     Q   QA+ +++               Q E+E  
Sbjct: 769  L-ESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERD 827

Query: 409  SRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTA 468
            + A +L   E++  GK A LE+  AAH +    L+EK++      E    Q E  KAL +
Sbjct: 828  AAARQLAQAEQE--GKTA-LEQQKAAHEKEVNQLREKWEK-----ERSWHQQELAKALES 879

Query: 469  SEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSAL--KETE 526
             E E ++LE               ++ Q ++ A ++  +E        Q +SAL   + E
Sbjct: 880  LEREKMELE------------MRLKEQQTEMEAIQAQREEE-----RTQAESALCQMQLE 922

Query: 527  IKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEE 586
             ++  VS L+ +   Q +L    +   +  +D + +K +++ TT  L  ++ + +    E
Sbjct: 923  TEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQ---RE 979

Query: 587  LYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSY-----AKLLGHQNLKQKIKH 641
            L    +  +  L A + E  +LL +    Q+Q+  ++        ++ L  Q +++K++ 
Sbjct: 980  LKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRE 1039

Query: 642  VVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 675
              +      +L+ E + L   L +K+Q    LQE
Sbjct: 1040 TQEYNRIQKELEREKASLTLSLMEKEQRLLVLQE 1073



 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 137/711 (19%), Positives = 306/711 (43%), Gaps = 71/711 (9%)

Query: 27   KTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLK 86
            +T+  L+  +   + QR + Q E ++ L   K+  L A    ++++  +  +Q +     
Sbjct: 1320 ETMASLQSRLRRAELQRMEAQGE-RELLQAAKEN-LTAQVEHLQAAVVEARAQASAAG-- 1375

Query: 87   ILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAA---LREKTSLSANNATLEKQLIE 143
            ILE+++R     R A   + +++E+E E+ +A        + +  +L  N A L + L E
Sbjct: 1376 ILEEDLRTA---RSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAE 1432

Query: 144  LTRTNELLKSKFSENGNQKNLRILSLELMKL----RNKRETKMRGMMAKQEGMEMKLQVT 199
                 E L+ +  E   Q+ ++  +LEL+ L    RN+     +  + + E     L+  
Sbjct: 1433 REEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHL 1492

Query: 200  QRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE----ISCASDQVEKYKLDI 255
              +++E + K+     ++  +EK++  +++  E  L  +E+    I     QV+  K  +
Sbjct: 1493 PMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQL 1552

Query: 256  A-------QLEEN---LKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHV 305
                    +LEEN   ++ +   I  L+   E   V L+    DL  + Q L+ +    +
Sbjct: 1553 VTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQ-I 1611

Query: 306  NRNREHNENLNAEMQNLKQKFILEQQEREKLQ-QKELQIDSLLQQEKELSSSLHQKLCSF 364
            +    H+  L  E+Q   Q+   ++++ E+LQ QKE     L ++++EL     +++   
Sbjct: 1612 HDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQ-KERIQVL 1670

Query: 365  QEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGK 424
            +++  ++  + EE+L+Q    L +  ++     +L+++  EE K  ++  +   E +K  
Sbjct: 1671 EDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLI 1730

Query: 425  EAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEK 484
              + EK      +    LQE  D + Q L+ +  +      L +   +++ +    LQE 
Sbjct: 1731 LRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEA 1790

Query: 485  AAKAGKNAEDVQHQILATE---SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDL 541
              +     + +Q Q+   +   +   + +  L   Q ++  +E  +KE   +    +   
Sbjct: 1791 REQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQA 1850

Query: 542  QNQLK------QQEEDFRKQLEDE---EGRKAEK-----ENTTAELTEEINKWRLLYEEL 587
               LK      Q  ++  ++LE+E   EGR+ +       +  AE  E+      L ++ 
Sbjct: 1851 HMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQC 1910

Query: 588  YNKTKPFQL---------------------QLDAFEVEKQALLNEHGAAQEQLNKIRDSY 626
              + +  ++                     +L+A   E Q+  ++  AA+ +   ++++ 
Sbjct: 1911 AEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEAL 1970

Query: 627  AKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEEL 677
             K   H  L+ K +H+++  + +  L++  + L+  L   +    +L+E L
Sbjct: 1971 GK--AHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEAL 2019



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 138/719 (19%), Positives = 299/719 (41%), Gaps = 66/719 (9%)

Query: 13  DPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQK--ESKQNLNVDK----DTTLPASA 66
           +P+G     G    + L +L      +K    + Q+  + K   +++K    D     SA
Sbjct: 231 EPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSA 290

Query: 67  RKVKSSESKKESQKNDKDLK----ILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNA 122
              +S +  ++ +K  K L+    ILE     L++   +  R  Q+ +  L+++   +  
Sbjct: 291 LLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQ 350

Query: 123 ALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKM 182
            + E+    A  +  E  L      +  + S+F      K L ++   L + R   +   
Sbjct: 351 VMVEEGDNIAQGSGHENSL----ELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLR 406

Query: 183 RGMMAKQEGMEMKLQVTQRSLEESQG---KIAQLEGKLVSIEKEKIDEKSETEKLLEYIE 239
           + +   QE + +  Q   +  EE +    ++ +L G+  ++  + +D + E + L +  E
Sbjct: 407 QQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERE 466

Query: 240 EISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK 299
            +  A +++ +    + Q    L+  N E+     S +       +Q E+L++  +  E+
Sbjct: 467 LLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQ---KEEQQEELHLAVRERER 523

Query: 300 EKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLL----QQEKELSS 355
            +E  +    + +E+L+ E+  L++       E E L+Q++ ++ + L    Q   ELSS
Sbjct: 524 LQEMLMGLEAKQSESLS-ELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSS 582

Query: 356 SLHQ-------------KLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQ 402
           S +              KL +  E +  +K    ++L Q  +E   +  + E AE+    
Sbjct: 583 SENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNA 642

Query: 403 LEEEAKSRAEELKLLEEKLKGKEAELEKS--SAAHTQATLL--------LQEKYDSMVQS 452
           L+ +     +  + L EK    EA+L+K+  + A  QA L         +Q+K       
Sbjct: 643 LQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQ 702

Query: 453 LEDVTAQFESYK----------ALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILAT 502
            E  T Q E             A    E E L  E ++L+ +     ++ +D+  Q+   
Sbjct: 703 QEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGL 762

Query: 503 ESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGR 562
            S+ +     L + Q ++++ E    ++ V  +Q +T  +  ++ +    + +L+ E  +
Sbjct: 763 SSAKELLESSLFEAQQQNSVIEVTKGQLEVQ-IQTVTQAKEVIQGEVRCLKLELDTERSQ 821

Query: 563 KAEKENTTAE---LTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQL 619
             ++ +  A      E+  K  L  ++  ++ +  QL+ + +E E+     E   A E L
Sbjct: 822 AEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLR-EKWEKERSWHQQELAKALESL 880

Query: 620 NKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQS--ETKLQEE 676
            + +      L  Q  + +     + ++E +Q +S + +++ +  K++ S  ET LQ +
Sbjct: 881 EREKMELEMRLKEQQTEMEAIQAQR-EEERTQAESALCQMQLETEKERVSLLETLLQTQ 938



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 153/762 (20%), Positives = 325/762 (42%), Gaps = 105/762 (13%)

Query: 39   QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQE 98
            Q+ +R +Q  +  Q L   + T +  +  +    E K+ ++++  DL  L++E   LLQ+
Sbjct: 946  QQLERLRQDMKV-QKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQD 1004

Query: 99   RGAQDRRIQDLETEL---------------EKMEA-----RLNAAL-REKTSLSANNATL 137
            +    ++++DL+++L               EK+       R+   L REK SL+ +    
Sbjct: 1005 KMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEK 1064

Query: 138  EKQLIELTRTNELLKSKFS--------ENGNQKNLRILSLELMKLRNKRETKMRGMMAKQ 189
            E++L+ L   + + + + S          G QK    LS ++  LR + + K    +A++
Sbjct: 1065 EQRLLVLQEADSIRQQELSALRQDMQEAQGEQKE---LSAQMELLRQEVKEKEADFLAQE 1121

Query: 190  EGMEMKLQ---VTQRSLEES----QGKIAQLEGKLVSIEK--EKIDEKSETEKLLEYIEE 240
              +  +L+   +T++ L  S    + K AQL+ +L S E   E +  + +     +   +
Sbjct: 1122 AQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQ 1181

Query: 241  ISCASDQVEKYKLDIAQLEENLKEKNDEILSL---------------------KQSLEEN 279
            ++     +++    + +    L    D   S+                       S E  
Sbjct: 1182 LASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAV 1241

Query: 280  IVILSKQVEDLNVKCQLLE------KEKEDHVNRNREHNENLNAEMQNLKQKFILEQQER 333
               L K  +DL    Q  +      ++ E+ +         ++ E+Q+L+++    Q+E+
Sbjct: 1242 ASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEK 1301

Query: 334  EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVK---EKNLFEEELKQTLDELDKLQ 390
             K + K+  ++S L +  E  +SL  +L   + + ++   E+ L +   +    +++ LQ
Sbjct: 1302 SKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQ 1361

Query: 391  QKEEQAERLVKQ---LEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATL------L 441
                +A         LEE+ ++    LKL  E++   E+E E++ A   Q  L       
Sbjct: 1362 AAVVEARAQASAAGILEEDLRTARSALKLKNEEV---ESERERAQALQEQGELKVAQGKA 1418

Query: 442  LQEKYDSMVQSLEDVTAQFESYKALTAS-----EIEDLKLENSSLQEKAAKAGKNAEDVQ 496
            LQE    + Q+L +   + E+ +          E++   LE  SL  K      + +  Q
Sbjct: 1419 LQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQ 1478

Query: 497  HQILATESSNQEYVRMLL-DLQTKSALKETEIKEITVSFLQKITDLQNQLKQQE------ 549
             Q L    S  E++ M + + + K  ++  +I+E+      +   L++QL + E      
Sbjct: 1479 IQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMI 1538

Query: 550  EDFRKQLEDEEGRKAEKENTTAELTEEINKW---RLLYEELYNKTKPFQLQLDAFEVEKQ 606
            E  R Q++D + +    E    EL E  +K    + L +EL  + +  ++ L    ++ +
Sbjct: 1539 ESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLE 1598

Query: 607  ALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKK 666
                E  A   Q++ + +S++ +L  + L+++ + V   +++  +L+ +   L   L ++
Sbjct: 1599 ERSQELQAQSSQIHDL-ESHSTVLARE-LQERDQEVKSQREQIEELQRQKEHLTQDLERR 1656

Query: 667  KQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKE 708
             Q E  LQ+E  +VL  +    +K    + ++   +K  L+E
Sbjct: 1657 DQ-ELMLQKERIQVLEDQRTRQTKILEEDLEQ---IKLSLRE 1694



 Score = 63.2 bits (152), Expect = 8e-10
 Identities = 117/567 (20%), Positives = 240/567 (42%), Gaps = 85/567 (14%)

Query: 40   KSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKD-LKILEKEIRVLLQE 98
            K Q  + Q +  Q     +D  L A  ++ + ++ ++E  K   D L+   ++  + L+E
Sbjct: 1797 KEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKE 1856

Query: 99   RGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSEN 158
            R  +   +QD + +  ++E  L    R   +L      L  +  E  +    L+ + +E 
Sbjct: 1857 RHGE---LQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQ 1913

Query: 159  GNQKNLRILSLE--------LMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKI 210
              +  +   +L+        ++K R++    +R         E   +    +L+E+ GK 
Sbjct: 1914 AQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKA 1973

Query: 211  -AQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEI 269
             A L+GK     ++ + E++E  + LE       AS    +  LD  Q            
Sbjct: 1974 HAALQGK-----EQHLLEQAELSRSLE-------ASTATLQASLDACQAHS--------- 2012

Query: 270  LSLKQSLEENIVILSKQVEDLNVK----CQLLEK---EKEDHVNRNREHNENLNAEMQNL 322
                + LEE + I   +++D +++     Q L++   ++++ +   +E  + L   +   
Sbjct: 2013 ----RQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQR 2068

Query: 323  KQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQE-EMVKEKNLFE----- 376
             Q+ ++++++    +++E +I  L Q  +EL  +L QK     E    +++N  E     
Sbjct: 2069 VQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHS 2128

Query: 377  ------EELKQTLDELD-KLQQKEEQAERLVKQLEE---EAKSRAEELKLLEEKLKGKEA 426
                  EE    LD L+ +LQ++ E+ +  ++Q E    E + +A++L L   + K   +
Sbjct: 2129 HKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVS 2188

Query: 427  ELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAA 486
             L++  A   QA++L   + DS  Q L+D          LT   +E  +L +      A 
Sbjct: 2189 SLQE-VAMFLQASVL---ERDSEQQRLQDEL-------ELTRRALEKERLHSPGATSTAE 2237

Query: 487  KAGKNAEDVQ-HQILATES-------SNQEYVRMLLDLQTKSALKETEIKEITVSFLQKI 538
               +  + VQ  ++   E+         Q + + L  LQ   A  E +   +    +Q  
Sbjct: 2238 LGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQ-- 2295

Query: 539  TDLQNQLKQQEEDFRKQLEDEEGRKAE 565
              L++ L+Q E + R++L+ E  R A+
Sbjct: 2296 --LRSTLEQVERE-RRKLKREAMRAAQ 2319



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 66/335 (19%), Positives = 140/335 (41%), Gaps = 43/335 (12%)

Query: 39   QKSQRFKQQKESKQNLNVD------KDTTLPASARKVKSSESKKESQKNDKDLKILEKEI 92
            QK Q   + +E++Q  N++      K + +   + K+ S E + + +       + + E 
Sbjct: 2105 QKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEA 2164

Query: 93   RVLLQERGAQDRRIQDLETE-----LEKMEARLNAALREKTSLSANNATLEKQLIELTRT 147
            R +     AQD  +   +T+     L+++   L A++ E+ S       L+ +L ELTR 
Sbjct: 2165 REIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDS---EQQRLQDEL-ELTR- 2219

Query: 148  NELLKSKFSENGNQKNLRILSLELMKLRNKRETKM---RGMMAKQEGMEMKLQVTQRSLE 204
              L K +    G      + S      R ++  ++    G+ A+     M+ Q  ++ LE
Sbjct: 2220 RALEKERLHSPGATSTAELGS------RGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLE 2273

Query: 205  ESQGKIAQLEGKLVSIEKEKIDEKSETEKL--------LEYIEEISCASDQVEKYKLDIA 256
              Q  +A+LE     +++  +  +S  E++         E +      S ++ K      
Sbjct: 2274 HLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSP 2333

Query: 257  QLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLN 316
              ++   +KN +   + + L++ +V+L  Q+        L  K+K+D++ R+ + +  L 
Sbjct: 2334 TQQDGRGQKNSDAKCVAE-LQKEVVLLQAQLT-------LERKQKQDYITRSAQTSRELA 2385

Query: 317  AEMQNLKQKFILEQQ--EREKLQQKELQIDSLLQQ 349
                +L    +   Q  E   L+ +  ++D  L Q
Sbjct: 2386 GLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQ 2420


>gi|32698688 citron [Homo sapiens]
          Length = 2027

 Score =  114 bits (286), Expect = 2e-25
 Identities = 141/636 (22%), Positives = 275/636 (43%), Gaps = 94/636 (14%)

Query: 70   KSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTS 129
            K+S  +K+     K+L+  + +   + QE     RR+ ++E  L + E  L A+  +++ 
Sbjct: 443  KTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSL 502

Query: 130  LSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQ 189
            L  + AT   +   L R+ E  + + S+  ++      +L+L+    ++  K++      
Sbjct: 503  LEQDLATYITECSSLKRSLEQARMEVSQEDDK------ALQLLHDIREQSRKLQ------ 550

Query: 190  EGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVE 249
               E+K Q  Q  +EE +  + QLE  LVS  +     +SE                 + 
Sbjct: 551  ---EIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESE-----------------LR 590

Query: 250  KYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNR 309
            + +L   + +    E   ++L  K   +  +   +K +E +N + QL  +E ++ + +  
Sbjct: 591  ESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAK-LEKINAEQQLKIQELQEKLEKAV 649

Query: 310  EHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMV 369
            + +      +QN++Q     ++E EKLQ +E           + S  + +KL   +E  +
Sbjct: 650  KASTEATELLQNIRQAKERAERELEKLQNRE-----------DSSEGIRKKLVEAEE--L 696

Query: 370  KEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELE 429
            +EK+   +   Q L+    L+QKE+  E  +K L+ + K    + + LE  ++  E E  
Sbjct: 697  EEKHREAQVSAQHLEV--HLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEE-- 752

Query: 430  KSSAAHTQATLLLQEK-----YDSMVQSLEDVTAQFESYKALTASE-------------- 470
                AH +  +L ++K      DS ++SLE    +      L A+               
Sbjct: 753  ----AHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEM 808

Query: 471  IEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEI 530
            I +L+ +   L+ +A K       ++ Q+      +      LL+L+T+      E +E 
Sbjct: 809  ISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQ 868

Query: 531  TVSFLQKITDLQNQLKQQEEDF------RKQLEDE-EGRKAEKENTTAELTEEINKWRLL 583
             +   +++T+LQ  L+++E         R  LE +    K E E TTAE  EEI      
Sbjct: 869  KLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAH 928

Query: 584  YEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQN--LKQKIKH 641
             +E+       Q + DA       + +     +EQLN++ +  A+ L +QN  L +++  
Sbjct: 929  RDEI-------QRKFDALRNSCTVITD----LEEQLNQLTEDNAE-LNNQNFYLSKQLDE 976

Query: 642  VVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEEL 677
                 DE  QL+SEV  LR ++ +++   T  ++ +
Sbjct: 977  ASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTM 1012



 Score =  108 bits (271), Expect = 1e-23
 Identities = 152/682 (22%), Positives = 289/682 (42%), Gaps = 72/682 (10%)

Query: 39   QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKE--SQKNDKDLKILEKEIRVLL 96
            QK    K  +  +  L  D  T +   +   +S E  +   SQ++DK L++L  +IR   
Sbjct: 488  QKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLH-DIRE-- 544

Query: 97   QERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFS 156
            Q R  Q+ + Q+ + ++E+M   +N    +  S    +   E +L E     E  K K +
Sbjct: 545  QSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKAT 604

Query: 157  ENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGK 216
            E  ++         L+K +++ + ++ G  AK E +  + Q+  + L+E   K  +   +
Sbjct: 605  ECQHK---------LLKAKDQGKPEV-GEYAKLEKINAEQQLKIQELQEKLEKAVKASTE 654

Query: 217  LVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSL---- 272
               + +     K   E+ LE ++    +S+ + K  ++  +LEE  +E       L    
Sbjct: 655  ATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHL 714

Query: 273  ---KQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILE 329
               +Q  EE I +L  Q     +K  L +KE  +  N  + H E  + + + L ++  + 
Sbjct: 715  KQKEQHYEEKIKVLDNQ-----IKKDLADKETLE--NMMQRHEEEAHEKGKILSEQKAMI 767

Query: 330  QQEREKLQQKELQIDSLLQQEK--ELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD 387
                 K++  E +I  L +  K    SS   Q+    QEEM+ E    +  L+    +L+
Sbjct: 768  NAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLE 827

Query: 388  KLQQK-EEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKY 446
               +K EEQ E++  Q        +++ +LLE + + +E  LE     H +  L L+ + 
Sbjct: 828  AQNRKLEEQLEKISHQ------DHSDKNRLLELETRLREVSLE-----HEEQKLELKRQL 876

Query: 447  DSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSN 506
              +  SL++  +Q  + +A  A+    L+   + L+E  A+A       + +I A  +  
Sbjct: 877  TELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEA-------EEEIQALTAHR 929

Query: 507  QEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEK 566
             E  R    L+    +               ITDL+ QL Q  ED   +L ++    +++
Sbjct: 930  DEIQRKFDALRNSCTV---------------ITDLEEQLNQLTED-NAELNNQNFYLSKQ 973

Query: 567  ENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSY 626
             +  +   +EI + R   + L  +    ++QL + +   +AL       +EQ+  +    
Sbjct: 974  LDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALN 1033

Query: 627  AKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHF 686
             +LL  +   +  + V  L DE SQ +  V +L+  L  +KQS  +  + + +   +   
Sbjct: 1034 DELLEKERQWEAWRSV--LGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVEL 1091

Query: 687  DPSKAFHHESKENFALKTPLKE 708
                A      E  AL+  LKE
Sbjct: 1092 ----AVKEHKAEILALQQALKE 1109



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 113/576 (19%), Positives = 229/576 (39%), Gaps = 113/576 (19%)

Query: 25   DVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKK----ESQK 80
            D +TLE +      +  ++ K   E K  +N           R V+ SE+ K     S  
Sbjct: 738  DKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLF 797

Query: 81   NDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARL-----------NAALREKTS 129
              +++K  E+ I  L Q++   + +   LE +  K+E +L           N  L  +T 
Sbjct: 798  TQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETR 857

Query: 130  LSANNATLEKQLIELTRTNELLKSKFSENGNQ------------KNLRILSLELMKLRNK 177
            L   +   E+Q +EL R    L+    E  +Q              LR    EL +   +
Sbjct: 858  LREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAE 917

Query: 178  RETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEY 237
             E +++ + A ++ ++ K      +L  S   I  LE +L  + ++  +  ++   L + 
Sbjct: 918  AEEEIQALTAHRDEIQRKFD----ALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQ 973

Query: 238  IEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEE---NIVILSKQVEDLNV-- 292
            ++E S A+D++ + + ++  L   + E+  ++ S KQ++E       +L +QV DL    
Sbjct: 974  LDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALN 1033

Query: 293  ------------------------KCQ------LLEKEKEDHVNRN-------------- 308
                                    +C+      +L+ EK+     +              
Sbjct: 1034 DELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAV 1093

Query: 309  REHNENLNAEMQNLKQKFILEQQEREKLQQKELQ----------IDSLLQQEKELSSSLH 358
            +EH   + A  Q LK++ +  +   +KL   E +          +   L+ E+EL   L 
Sbjct: 1094 KEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLL 1153

Query: 359  QKLCSFQEEMVKEKN---LFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELK 415
            ++    Q++M  +KN      + L++ LD  D L+ +    E  ++ +         ++ 
Sbjct: 1154 EEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENI---------QVL 1204

Query: 416  LLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTAS---EIE 472
               EK+K     +E + +  T+    LQ K D   +  + + ++ +   AL      +  
Sbjct: 1205 YSHEKVK-----MEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYN 1259

Query: 473  DLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQE 508
            +LKL   +L+++ A+  +  E +Q   +   S+ +E
Sbjct: 1260 ELKL---ALEKEKARCAELEEALQKTRIELRSAREE 1292


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score =  114 bits (286), Expect = 2e-25
 Identities = 132/569 (23%), Positives = 250/569 (43%), Gaps = 64/569 (11%)

Query: 172  MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKID--- 226
            M L  K +  ++   A++E   MK   + T+  L  S+ +  +LE K+VS+ +EK D   
Sbjct: 834  MNLFFKIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQL 893

Query: 227  -EKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEK---NDEILSLKQSLEENIVI 282
              +SETE L++  E            +  + +L E L+E+   N E+++ K++LE+    
Sbjct: 894  QVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSS 953

Query: 283  LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNL----KQKFILE---QQEREK 335
            L + ++DL +    +EKEK    N+ +  +E + A  +N+    K+K  L+   QQ  + 
Sbjct: 954  LKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDD 1013

Query: 336  LQQKELQIDSLL-------QQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDK 388
            LQ +E +++ L+       QQ  +L  SL Q+    + ++ + K   E +LK + + +  
Sbjct: 1014 LQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEK-KLRADLERAKRKLEGDLKMSQESIMD 1072

Query: 389  LQQKEEQAERLVKQLEEE-----AKSRAEELKLLEEKLKGKE-----AELEKSSAAHTQA 438
            L+  ++Q E  +K+ E E     AK   E++  L+ + K KE      ELE+   A    
Sbjct: 1073 LENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTL 1132

Query: 439  TLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLK------------LENSSLQEKAA 486
               ++++   + + LE+++ + E     T+++IE  K            LE ++LQ +A 
Sbjct: 1133 RAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEAT 1192

Query: 487  KA---GKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQK------ 537
             A    K A+ V    L  +  N + V+  L+ +      E +     +  L K      
Sbjct: 1193 AATLRKKQADSVAE--LGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIE 1250

Query: 538  -----ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTK 592
                 + D  +++K ++E   + + D   +KA  +    EL+  + +   L  +L    +
Sbjct: 1251 RTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQ 1310

Query: 593  PFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL 652
                QL+  + + +       A    L   R     L      +Q+ K   +L+   S+ 
Sbjct: 1311 ALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAK--AELQRALSKA 1368

Query: 653  KSEVSKLRCQLAKKKQSETKLQEELNKVL 681
             SEV++ R +        T+  EE  K L
Sbjct: 1369 NSEVAQWRTKYETDAIQRTEELEEAKKKL 1397



 Score =  112 bits (280), Expect = 1e-24
 Identities = 140/684 (20%), Positives = 297/684 (43%), Gaps = 82/684 (11%)

Query: 42   QRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGA 101
            +R K++ E    ++ +    L    ++++    KKE + +    KI ++++  L  ++  
Sbjct: 1053 ERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQK-- 1110

Query: 102  QDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQ 161
               +I++L+  +E++E  + A   E T      A +EKQ  +L R  E +  +  E    
Sbjct: 1111 ---KIKELQARIEELEEEIEA---EHTL----RAKIEKQRSDLARELEEISERLEEASGA 1160

Query: 162  KNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG--------KIAQL 213
             + +I      ++  KRE + + M    E   ++ + T  +L + Q         +I  L
Sbjct: 1161 TSAQI------EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNL 1214

Query: 214  EGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLK 273
            +     +EKEK + K E + +   IE +S +   +E+    +      +K K+++   L 
Sbjct: 1215 QRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLI 1274

Query: 274  QSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQER 333
              L      L  Q  +L+ + +    EKE  +++  +  + L  +++ LK++  +E++ +
Sbjct: 1275 HDLNMQKARLQTQNGELSHRVE----EKESLISQLTKSKQALTQQLEELKRQ--MEEETK 1328

Query: 334  EK------LQQKELQIDSLLQQ---EKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLD 384
             K      LQ      D L +Q   E+E  + L + L     E+ + +  +E +  Q  +
Sbjct: 1329 AKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTE 1388

Query: 385  ELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKS-SAAHTQATLLLQ 443
            EL++ ++K  Q  +  ++  E A S+   L+  +++L+G+  +L +    +HT    L  
Sbjct: 1389 ELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATL-- 1446

Query: 444  EKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATE 503
               D   ++ + V A+++     + +E+E  + E+ SL  +  K     E+V  Q+    
Sbjct: 1447 ---DKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLR 1503

Query: 504  SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRK 563
              N+     + DL        TE    T   LQ+    +  ++Q++ D +  LE+ EG  
Sbjct: 1504 RENKNLQEEISDL--------TEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSL 1555

Query: 564  AEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIR 623
              +E+    +  E+++   +  EL  K       ++  E  +Q   N   AA E L  + 
Sbjct: 1556 EHEESKILRVQLELSQ---VKSELDRKV------IEKDEEIEQLKRNSQRAA-EALQSVL 1605

Query: 624  DSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLG- 682
            D+  +    +N   ++K          +++ +++++  QL    +   + Q+ L  V G 
Sbjct: 1606 DAEIR---SRNDALRLK---------KKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQ 1653

Query: 683  IK----HFDPSKAFHHESKENFAL 702
            +K    H D +   + + KE  A+
Sbjct: 1654 LKDSQLHLDDALRSNEDLKEQLAI 1677



 Score =  110 bits (274), Expect = 6e-24
 Identities = 144/663 (21%), Positives = 285/663 (42%), Gaps = 70/663 (10%)

Query: 74   SKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSAN 133
            +K+E  +++   K LE+++  LLQE+     ++Q     L   E R    ++ K  L A 
Sbjct: 863  TKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAK 922

Query: 134  NATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGME 193
               L ++L E    N                     EL+  +   E K   +    + +E
Sbjct: 923  VKELTERLEEEEEMNS--------------------ELVAKKRNLEDKCSSLKRDIDDLE 962

Query: 194  MKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 253
            + L   ++    ++ K+  L  ++ ++E E I + ++ +K L+   + +    QVE+ K+
Sbjct: 963  LTLTKVEKEKHATENKVKNLSEEMTALE-ENISKLTKEKKSLQEAHQQTLDDLQVEEDKV 1021

Query: 254  D-IAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHN 312
            + + ++   L+++ D+   L+ SLE        Q + L    +  +++ E  +  ++E  
Sbjct: 1022 NGLIKINAKLEQQTDD---LEGSLE--------QEKKLRADLERAKRKLEGDLKMSQESI 1070

Query: 313  ENLNAEMQNLKQKFILEQQEREKLQQK--ELQIDSLLQQEKELSSSLHQKLCSFQEEMVK 370
             +L  + Q +++K   ++ E  +LQ K  + Q+ SL  Q+K     L  ++   +EE+  
Sbjct: 1071 MDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKK--IKELQARIEELEEEIEA 1128

Query: 371  EKNLFEEELKQTLD---ELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAE 427
            E  L  +  KQ  D   EL+++ ++ E+A        E  K R  E + +   L  +EA 
Sbjct: 1129 EHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDL--EEAT 1186

Query: 428  LEKSSAAHTQATLLLQEKYDSM------VQSLEDVTAQFESYKALTASEIEDLKLENSSL 481
            L+  + A T    L +++ DS+      + +L+ V  + E  K+    EI+D+     +L
Sbjct: 1187 LQHEATAAT----LRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEAL 1242

Query: 482  QEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEIT------VSFL 535
             +  +   +    V+ Q    ++ +++  +++ DL  + A  +T+  E++       S +
Sbjct: 1243 SKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLI 1302

Query: 536  QKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQ 595
             ++T  +  L QQ E+ ++Q+E+E   K    +       + +  R  YEE        Q
Sbjct: 1303 SQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQ 1362

Query: 596  LQLDA--FEVEKQALLNEHGAAQ--EQLNKIRDSYAKLL--GHQNLKQKIKHVVKLKDEN 649
              L     EV +     E  A Q  E+L + +   A+ L    +N +        L+   
Sbjct: 1363 RALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTK 1422

Query: 650  SQLKSEVSKLRCQLAKKK---QSETKLQEELNKVLG--IKHFDPSKA-FHHESKENFALK 703
             +L+ EV  L   L +      +  K Q   +KVL    +  D S+A      KE+ +L 
Sbjct: 1423 QRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLS 1482

Query: 704  TPL 706
            T L
Sbjct: 1483 TEL 1485



 Score = 87.4 bits (215), Expect = 4e-17
 Identities = 142/660 (21%), Positives = 284/660 (43%), Gaps = 97/660 (14%)

Query: 45   KQQKESKQNLNVDKDTTLPASARKVKSSESKKESQ--KNDKDLKILEKEIRVLLQERGAQ 102
            ++Q E +Q    +    L  +  +V    +K E+   +  ++L+  +K++   LQE    
Sbjct: 1348 REQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEN 1407

Query: 103  DRRIQDLETELEKMEARLNAA----LREKTSLSANNATLEKQLIELTRTNELLKSKFSEN 158
                      LEK + RL       +R+        ATL+K+     +     K K  E+
Sbjct: 1408 TETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDES 1467

Query: 159  -----GNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQL 213
                   QK  R LS EL K+RN  E     ++ + E +  + +  Q  + +   +IA+ 
Sbjct: 1468 QAELEAAQKESRSLSTELFKMRNAYEE----VVDQLETLRRENKNLQEEISDLTEQIAET 1523

Query: 214  EGKLVSIEKEKI---DEKSETEKLLEYIE-EISCASDQVEKYKLDIAQLEENLK----EK 265
               L   EK K     EKS+ +  LE +E  +     ++ + +L+++Q++  L     EK
Sbjct: 1524 GKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEK 1583

Query: 266  NDEILSLKQSLEENIVILSKQVEDLNVKCQ----LLEKEKEDHVNRNREHNENLNAEMQN 321
            ++EI  LK++ +     L + V D  ++ +     L+K+ E  +N       + N +M  
Sbjct: 1584 DEEIEQLKRNSQRAAEAL-QSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAE 1642

Query: 322  LKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQ 381
             ++     Q +   L+  +L +D  L+  ++L   L          +V+ +N        
Sbjct: 1643 TQKHLRTVQGQ---LKDSQLHLDDALRSNEDLKEQL---------AIVERRNGL------ 1684

Query: 382  TLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLL 441
             L+EL++++   EQ ER  +  E+E    ++ ++LL                 H+Q T L
Sbjct: 1685 LLEELEEMKVALEQTERTRRLSEQELLDASDRVQLL-----------------HSQNTSL 1727

Query: 442  LQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILA 501
            +  K     + LE   AQ ++       E+E+   E+ + +EKA KA  +A  +  ++  
Sbjct: 1728 INTK-----KKLEADIAQCQA-------EVENSIQESRNAEEKAKKAITDAAMMAEELKK 1775

Query: 502  TESSNQEYVRMLLDL-QTKSALKE--TEIKEITVSFLQK-ITDLQNQLKQQEEDFRKQLE 557
             + ++    RM  +L QT   L+    E +++ +   +K I  L+N++++ E     +L+
Sbjct: 1776 EQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELE----NELD 1831

Query: 558  DEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE 617
             E+ R AE      +   ++ +     EE +      Q  +D  + + ++   +   A+E
Sbjct: 1832 VEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEE 1891

Query: 618  QLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL-KSEVSKLRCQLAKKKQSETKLQEE 676
            Q N             +  ++++H ++   E + + +S+V+KLR   AK +   ++  EE
Sbjct: 1892 QANT----------QLSRCRRVQHELEEAAERADIAESQVNKLR---AKSRDVGSQKMEE 1938


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score =  114 bits (285), Expect = 3e-25
 Identities = 166/707 (23%), Positives = 319/707 (45%), Gaps = 93/707 (13%)

Query: 27   KTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLK 86
            + LE L+G  S   ++   + +E+     + +D      A K + +E+  +++    +L+
Sbjct: 666  RQLEQLEGKRSVL-AKELVEVREALSRATLQRDML---QAEKAEVAEALTKAEAGRVELE 721

Query: 87   ILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELT- 145
            +   ++R       A++  +QD    L K+ A   +  ++K  L+   A LE++   L  
Sbjct: 722  LSMTKLR-------AEEASLQD---SLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQG 771

Query: 146  RTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEE 205
            R  +  +        Q+ L  L LE    R   E  +R     QE +E +L   +    +
Sbjct: 772  RQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQ 831

Query: 206  SQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEK------YKLDIAQLE 259
             Q ++AQL  +L   E+E    + E ++ +E +E  +   + + K       +L  A+ E
Sbjct: 832  LQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAERE 891

Query: 260  -ENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAE 318
               L E+   +   K++LE ++  + +Q+  L  + + LE E +  +       E L  E
Sbjct: 892  GRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAK----ETLTGE 947

Query: 319  MQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEE---MVKEKNLF 375
            +  L+Q+ I+  QE+  L  KEL    L+Q E+E  +SL ++  + +E+   + +EK   
Sbjct: 948  LAGLRQQ-IIATQEKASLD-KELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAA 1005

Query: 376  EEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLL----EEKLKGKEAELEKS 431
              EL+    +L    Q+E+  E L+ +LE E +  +EE+  L    +E L   E+E +++
Sbjct: 1006 WRELEAERAQLQSQLQREQ--EELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQA 1063

Query: 432  SAAHTQATLLLQEKYDSMVQSLEDVTAQFESYK---------------ALTASEIEDLKL 476
             +        L EK      SL  ++ + E  K               ALT SE+ DL+ 
Sbjct: 1064 LSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALT-SELRDLRA 1122

Query: 477  ENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQ 536
            +    +E+AA A  +A++V+          QE  R  L  Q  S L+E E     +  L+
Sbjct: 1123 Q----REEAAAA--HAQEVRRL--------QEQARD-LGKQRDSCLREAEELRTQLRLLE 1167

Query: 537  KITD-LQNQLKQQEEDFRKQLEDEEGRKAEKE------NTTAELTEEINKWRLLYEELYN 589
               D L+ +L + +   RK  E +EGR+ +++       +  E  +E    R   EEL +
Sbjct: 1168 DARDGLRRELLEAQ---RKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRS 1224

Query: 590  KTKPFQLQLDAFEV------EKQALLNE-HGAAQEQLNKIRDSY-----AKLLGHQNLKQ 637
              K  + +  + ++      +K ALL E   A  ++  ++R        ++L   + L++
Sbjct: 1225 AVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQE 1284

Query: 638  KIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIK 684
              + +  L  EN++L  E+++L+ +LA  +++E   +E   + LG++
Sbjct: 1285 LRRQMKMLDSENTRLGRELAELQGRLALGERAE---KESRRETLGLR 1328



 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 132/678 (19%), Positives = 282/678 (41%), Gaps = 95/678 (14%)

Query: 39   QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKND-----KDLKILEKEIR 93
            Q++   ++++E  + L ++++         ++ +E  +E+ +        +   L++++ 
Sbjct: 778  QEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLA 837

Query: 94   VLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKS 153
             L ++   +++ ++    E ++    L  A REK +L+  +A L  QL+   R    L  
Sbjct: 838  QLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTL-- 895

Query: 154  KFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQL 213
              SE   +  L   +LE      +R+  +  + A++E +E + Q    + E   G++A L
Sbjct: 896  --SEEATRLRLEKEALEGSLFEVQRQ--LAQLEARREQLEAEGQALLLAKETLTGELAGL 951

Query: 214  EGKLVSI-EKEKIDEKSETEKLLEYIEEISCA-SDQVEKYKLDI---------------- 255
              ++++  EK  +D++   +KL++   E   +  +Q   ++ D+                
Sbjct: 952  RQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEA 1011

Query: 256  --AQLEENLKEKNDEILSL----KQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNR 309
              AQL+  L+ + +E+L+     K+ L E I  L ++ ++      L E EK+  ++   
Sbjct: 1012 ERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDE---GLLLAESEKQQALSLKE 1068

Query: 310  EHNENLNAEMQNLKQKFI-----LEQQEREKLQQKEL----------QIDSLLQQEKELS 354
                 L+ ++   +         +E+Q+R+   ++E           ++  L  Q +E +
Sbjct: 1069 SEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAA 1128

Query: 355  SSLHQKLCSFQEEM----------VKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLE 404
            ++  Q++   QE+           ++E      +L+   D  D L+++  +A+R +++ +
Sbjct: 1129 AAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQ 1188

Query: 405  EEAKSRAEEL----KLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVT--- 457
            E  + + +E     + L E  K +EA L +S+     A    + +  S+  + ED     
Sbjct: 1189 EGREVQRQEAGELRRSLGEGAKEREA-LRRSNEELRSAVKKAESERISLKLANEDKEQKL 1247

Query: 458  AQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQ 517
            A  E  +     E  +L+     ++    +A +  ++++ Q+   +S N    R L +LQ
Sbjct: 1248 ALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQ 1307

Query: 518  TKSALKETEIKEITVSFL-----------------QKITDLQNQLKQQEEDFRKQLEDEE 560
             + AL E   KE     L                 Q++   Q +L++QE +FR +     
Sbjct: 1308 GRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLL 1367

Query: 561  GRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNE-------HG 613
            G   E   T  +  +      L  E    +     L+L A E   Q L  E         
Sbjct: 1368 GSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRR 1427

Query: 614  AAQEQLNKIRDSYAKLLG 631
            AA+ QL  +R +  + LG
Sbjct: 1428 AAEAQLGGLRSALRRGLG 1445



 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 151/697 (21%), Positives = 300/697 (43%), Gaps = 111/697 (15%)

Query: 60  TTLPASARKVKSSE-SKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEA 118
           T+LPA  R++ +   S+ ES      L   E    + LQE        Q L+ EL ++E 
Sbjct: 45  TSLPALIREIVTRNLSQPESPVL---LPATEMASLLSLQEEN------QLLQQELSRVED 95

Query: 119 RLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMK-LRNK 177
            L  +  E+  L+     + ++L +  R    L+    E    + L   S+EL + L+ +
Sbjct: 96  LLAQSRAERDELAIKYNAVSERLEQALR----LEPGELETQEPRGLVRQSVELRRQLQEE 151

Query: 178 RETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKL--- 234
           + +  R + A QEG + + Q+ QR     QGKI Q + +   +E++ ++   E E+    
Sbjct: 152 QASYRRKLQAYQEGQQRQAQLVQRL----QGKILQYKKRCSELEQQLLERSGELEQQRLR 207

Query: 235 -LEYIEEISCASDQVEKYK---LDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDL 290
             E+ +++  A  ++E+ +     +AQ+   L+E+ D+  S  Q+L E+I    ++V + 
Sbjct: 208 DTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDI----RKVTND 263

Query: 291 NVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ----------------ERE 334
             +C+   KE E      R   E+ NA   N   + +L  +                ER+
Sbjct: 264 WTRCR---KELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERD 320

Query: 335 KLQ------------------------QKELQIDSLLQQEKELSSSLHQKLCSFQEEMVK 370
            LQ                          E + ++ L+++  L + L ++L   ++++++
Sbjct: 321 LLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQL---RDKVLR 377

Query: 371 EKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEA-ELE 429
           EK+L +++++  LD+ D L  +  +    VK+LE++   + +  K L EKL+  E+  L+
Sbjct: 378 EKDLAQQQMQSDLDKAD-LSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQ 436

Query: 430 KSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASE---------IEDLKLENSS 480
           + +A  T+    LQ+    + Q+   V +  ES   L+ SE         +  L  + + 
Sbjct: 437 EQAALETEDGEGLQQTLRDLAQA---VLSDSESGVQLSGSERTADASNGSLRGLSGQRTP 493

Query: 481 LQEKAAKAGKNAEDVQHQILA-TESSNQEYVRMLL---DLQTKSALKETEIKEITVSFLQ 536
              + +  G+     +    A ++SS    +   L    LQ +      E  +  +  L+
Sbjct: 494 SPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLR 553

Query: 537 K-ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQ 595
           K ++D +++ +  EE  ++  +  +G     E+   E+    +   LL  E  N     Q
Sbjct: 554 KQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQ 613

Query: 596 L---QLDAFEVEKQALLNEHGAAQEQLNKIRDSYAK---------LLGHQNLKQKIKHVV 643
           +   Q +    E++ L     AAQE+L + RD   +             + L++  + + 
Sbjct: 614 VAQQQAEELRQEREKL----QAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLE 669

Query: 644 KLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKV 680
           +L+ + S L  E+ ++R  L++       LQ E  +V
Sbjct: 670 QLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEV 706



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 127/635 (20%), Positives = 267/635 (42%), Gaps = 74/635 (11%)

Query: 69  VKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRI--QDLETELEKMEARLNAALRE 126
           ++ +ES+ E+    + L  L+ ++   L+++  +++ +  Q ++++L+K  A L+A +  
Sbjct: 346 LRLAESRAEAALEKQAL--LQAQLEEQLRDKVLREKDLAQQQMQSDLDK--ADLSARV-- 399

Query: 127 KTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMM 186
            T L      LEKQ +E  + N+ L  K     + +     +LE       ++T      
Sbjct: 400 -TELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQ 458

Query: 187 AKQEGMEMKLQVT--QRSLEESQGKIAQLEGKLVSIEKEKIDE------KSETEKLLEYI 238
           A     E  +Q++  +R+ + S G +  L G+       +         +          
Sbjct: 459 AVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDS 518

Query: 239 EEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSL---EENIVILSKQVEDLNVKCQ 295
             ++     + K +L +  +    +   D + +L++ L   E     L +Q++ L  K  
Sbjct: 519 STLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTD 578

Query: 296 LLEKEKED---HVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKE 352
              +  ED    V R R  NE L+ E  NL     + QQ+ E+L+Q+             
Sbjct: 579 GAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQER------------ 626

Query: 353 LSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAE 412
                 +KL + QEE+ ++++  EEE +  + +  +++++ E++ R ++QLE +    A+
Sbjct: 627 ------EKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAK 680

Query: 413 ELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIE 472
           EL  + E L          S A  Q  +L  EK +      +    + E   ++T    E
Sbjct: 681 ELVEVREAL----------SRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAE 730

Query: 473 DLKLEN-----SSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEI 527
           +  L++     S+L E  A+   +   +  Q+   +S+ Q   R      T +  ++  +
Sbjct: 731 EASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERL 790

Query: 528 KEITVSFLQKITDLQNQLK---QQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLY 584
           +E+ +        L+  L+   Q +E   +QL      +++ +   A+L+ +++      
Sbjct: 791 EELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGRE--- 847

Query: 585 EELYNKTKPFQLQLDAFE---VEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKH 641
           +EL    +  Q Q++A E    EK+AL  EH     QL         +   +  +   + 
Sbjct: 848 QELEQARREAQRQVEALERAAREKEALAKEHAGLAVQL---------VAAEREGRTLSEE 898

Query: 642 VVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEE 676
             +L+ E   L+  + +++ QLA+ +    +L+ E
Sbjct: 899 ATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAE 933



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 105/531 (19%), Positives = 232/531 (43%), Gaps = 26/531 (4%)

Query: 16   GCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESK 75
            G A SP + D+   E ++G +     + F Q+  S Q    +  T   A  R++   E++
Sbjct: 1492 GPATSPASPDLDP-EAVRGAL-----REFLQELRSAQRERDELRTQTSALNRQLAEMEAE 1545

Query: 76   KESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNA 135
            ++S  +    + L+K +    + R + D R+  ++ EL   E  +  + RE+ +     A
Sbjct: 1546 RDSATSRA--RQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVA 1603

Query: 136  TLEKQLIELTRTNELLKSKFSE-NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEM 194
            TLE+ L          + K S+   N+  L      L ++ +  E++   +  ++  +E 
Sbjct: 1604 TLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEG 1663

Query: 195  KLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLD 254
            +LQ ++  L + + +   L+ ++ S++++  D + +   L   +E ++ A  +VE+ +  
Sbjct: 1664 ELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGA 1723

Query: 255  IAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE---DHVNRNREH 311
            +      L E   +  +   S  +  + L K +       Q+L++  +     ++  R+ 
Sbjct: 1724 LRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQ 1783

Query: 312  NENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKE 371
            + +L  ++Q L+ +    + +R + + +  Q+  +L+Q +E  ++    +   Q+    E
Sbjct: 1784 SSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQD----E 1839

Query: 372  KNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEEL-KLLEEKLKGKE----- 425
            + L +E L      L +L+ ++ + ER   +LE++  +    L K+  EKL+  E     
Sbjct: 1840 RRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRL 1899

Query: 426  -AELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEK 484
             AE  +     T A L L E     +Q LE      E   +    E+ D + +   LQ++
Sbjct: 1900 SAEKGRLDRTLTGAELELAEA-QRQIQQLEAQVVVLEQSHSPAQLEV-DAQQQQLELQQE 1957

Query: 485  AAKAGKNAEDVQHQILATESSNQEYVRMLLD-LQTKSALKETEIKEITVSF 534
              +        +  + A E ++++ VR L + + T     + E++  +  F
Sbjct: 1958 VERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSSAPF 2008


>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
          Length = 2325

 Score =  114 bits (284), Expect = 4e-25
 Identities = 143/636 (22%), Positives = 288/636 (45%), Gaps = 70/636 (11%)

Query: 66   ARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALR 125
            ++K +    +   ++++K+++ L   I  LLQE+       + LE E+E++   +    +
Sbjct: 1337 SKKREERWMRASKRQSEKEMEELHHNIDDLLQEK-------KSLECEVEELHRTVQKRQQ 1389

Query: 126  EKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGM 185
            +K  +  N  +L  +L       E+ KS          +  +   L+K R++     R +
Sbjct: 1390 QKDFIDGNVESLMTEL-------EIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLL 1442

Query: 186  MAKQEGMEMKLQVTQRSLE---ESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEIS 242
               +  +    + T+ ++E   +++  + Q E     +E+   +      K  + +  + 
Sbjct: 1443 AEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQ 1502

Query: 243  CASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE 302
              +  +E++K+   + EE LKE N +I++ K S   +   LSK+ E L  + Q L+K+ E
Sbjct: 1503 ADAKDLEQHKI---KQEEILKEIN-KIVAAKDS---DFQCLSKKKEKLTEELQKLQKDIE 1555

Query: 303  DHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLC 362
                RN +H+      +Q LK+  +L Q +R +L++ + Q+ S  Q+   L   L  K  
Sbjct: 1556 -MAERNEDHH------LQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKK- 1607

Query: 363  SFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLK 422
                   +E +L +  + Q   +L       ++A RL +    E  +   E+K L E+L 
Sbjct: 1608 -------EELHLLQGSMVQAKADL-------QEALRLGETEVTEKCNHIREVKSLLEELS 1653

Query: 423  GKEAELE-KSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSL 481
             ++ EL  + S   TQ TL+ QE  +   ++L+ V  Q   +K    + ++ L+LEN  L
Sbjct: 1654 FQKGELNVQISERKTQLTLIKQE-IEKEEENLQVVLRQMSKHKTELKNILDMLQLENHEL 1712

Query: 482  Q-------EKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEI--TV 532
            Q       ++ ++  K    V  + L  E+  Q   +   +++ +  L E + +EI    
Sbjct: 1713 QGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMT 1772

Query: 533  SFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTK 592
            +  + +      L +++ED +++ +  E + A+ +   A   E     +   E+L    +
Sbjct: 1773 AESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVR 1832

Query: 593  PFQLQLDAFEVEKQALLNEHGAAQEQL-------NKIRDSYAKLLGHQNL-KQKIKHVVK 644
              Q +LD    +K +L N+  A Q+QL       N +++  A +  H NL KQ + H  K
Sbjct: 1833 KLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTK 1892

Query: 645  LKD----ENSQLKSEVSKLRCQLAK-KKQSETKLQE 675
             +D    E ++L+ ++S+   +    +K+ ETK Q+
Sbjct: 1893 HQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQ 1928



 Score =  108 bits (270), Expect = 2e-23
 Identities = 152/677 (22%), Positives = 311/677 (45%), Gaps = 81/677 (11%)

Query: 39   QKSQRFKQQKESKQNLNVDK-DTTLPASARKVKSSESKKESQKNDKDLKIL-------EK 90
            +K    ++ K   + L+  K +  +  S RK + +  K+E +K +++L+++       + 
Sbjct: 1637 EKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKT 1696

Query: 91   EIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNEL 150
            E++ +L     ++  +Q L+ + ++  + L     EKT +    A LE++L EL    ++
Sbjct: 1697 ELKNILDMLQLENHELQGLKLQHDQRVSEL-----EKTQV----AVLEEKL-ELENLQQI 1746

Query: 151  LKSKFSENGNQKNLRILSLELMKLRNKRET-KMRGMMAKQEGMEMKLQVTQRSLEESQGK 209
             + +  E   QK L    LE  K   +R T + R + +  E +  + +  Q   +  + K
Sbjct: 1747 SQQQKGEIEWQKQL----LERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKK 1802

Query: 210  IAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL----DIAQLEENLKEK 265
            +AQ +  L + E+    E+S  EKL   + ++    DQ+ + KL    DI+ +++ L+EK
Sbjct: 1803 LAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEK 1862

Query: 266  NDEILSLKQSL----------EENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENL 315
             + + SL++ L          +++++  +K  + L  +   L+K+  +  NR     E+ 
Sbjct: 1863 REAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRF----EDC 1918

Query: 316  NAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLF 375
              E +  +Q+  + Q E E+ + K +Q + + Q+ ++   S   KL + +  + ++++  
Sbjct: 1919 QKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQL 1978

Query: 376  EEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAH 435
            E+EL     +LD++  K   AE  V+ L+EE +   E L+    + K + +E E+     
Sbjct: 1979 EKELTDQKSKLDQVLSKVLAAEERVRTLQEEER-WCESLEKTLSQTKRQLSEREQQLVEK 2037

Query: 436  TQATLLLQEKYDSMVQSLEDVTAQF--ESYKA--LTASEIEDLKLENSSLQEKAAKAGKN 491
            +   L LQ++ DSM      +  QF  E  KA    AS  E LK++ S L++   +  + 
Sbjct: 2038 SGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQE 2097

Query: 492  AEDVQHQILATE---SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQ 548
               +Q ++   E     N E  R L+           E+ ++   +    T+L+ Q+  Q
Sbjct: 2098 NSCIQKEMATIELVAQDNHERARRLM----------KELNQMQYEY----TELKKQMANQ 2143

Query: 549  EEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEEL-------YNKTKPFQLQLDAF 601
            ++  R+Q+E  +  +  K     E+   +        EL         + +  + +L++ 
Sbjct: 2144 KDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESL 2203

Query: 602  EVEKQALLNEHGAAQEQLN----KIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVS 657
            +      +NE G  +E+LN     I D + +    + L++K++H  +     +QL+  +S
Sbjct: 2204 KENLPFTMNE-GPFEEKLNFSQVHIMDEHWR---GEALREKLRH--REDRLKAQLRHCMS 2257

Query: 658  KLRCQLAK-KKQSETKL 673
            K    L K K+Q+E  L
Sbjct: 2258 KQAEVLIKGKRQTEGTL 2274



 Score =  106 bits (264), Expect = 9e-23
 Identities = 141/682 (20%), Positives = 309/682 (45%), Gaps = 73/682 (10%)

Query: 49   ESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQD 108
            E++  L+  K+ T  A  +   +  S  +++ + ++L+   +E  V L +   Q R +Q 
Sbjct: 1444 EAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQA 1503

Query: 109  LETELEKMEARLNAALREKTSLSANNAT----LEKQLIELTRTNELLKS--KFSENGNQK 162
               +LE+ + +    L+E   + A   +    L K+  +LT   + L+   + +E     
Sbjct: 1504 DAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDH 1563

Query: 163  NLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEK 222
            +L++L    + L+ KR  ++  + ++    + ++ V  R L   + ++  L+G +V  + 
Sbjct: 1564 HLQVLKESEVLLQAKR-AELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKA 1622

Query: 223  E-----KIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSL- 276
            +     ++ E   TEK   +I E+    +++   K    +L   + E+  ++  +KQ + 
Sbjct: 1623 DLQEALRLGETEVTEK-CNHIREVKSLLEELSFQK---GELNVQISERKTQLTLIKQEIE 1678

Query: 277  --EENIVI----LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQ 330
              EEN+ +    +SK   +L     +L+ E  +      +H++ + +E++  +   + E+
Sbjct: 1679 KEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRV-SELEKTQVAVLEEK 1737

Query: 331  QEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFE-------EELKQTL 383
             E E LQQ   Q    ++ +K+L     +++    E M  E    +       +E +   
Sbjct: 1738 LELENLQQISQQQKGEIEWQKQLLERDKREI----ERMTAESRALQSCVECLSKEKEDLQ 1793

Query: 384  DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSS----AAHTQAT 439
            ++ D  ++K  Q +R++   EE +K     L+ LE  ++  + EL++ +    + H   +
Sbjct: 1794 EKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDIS 1853

Query: 440  LL---LQEKYDSMVQSLEDVTAQFESYKALTASEI------EDLKL-ENSSLQEKAAKAG 489
             +   LQEK ++ V SL++  A  + +  L   ++      +D+ L E + LQ+  ++  
Sbjct: 1854 AMQQQLQEKREA-VNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWA 1912

Query: 490  KNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQ----- 544
               ED Q +    E + Q+ +++L +   ++ LK  + +E+    LQK  + +       
Sbjct: 1913 NRFEDCQKE----EETKQQQLQVLQNEIEENKLKLVQ-QEMMFQRLQKERESEESKLETS 1967

Query: 545  ---LKQQEEDFRKQLEDEEGR------KAEKENTTAELTEEINKWRLLYEELYNKTKPFQ 595
               LK+Q+    K+L D++ +      K           +E  +W    E+  ++TK   
Sbjct: 1968 KVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQL 2027

Query: 596  LQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSE 655
             + +   VEK     E  A Q++ + +R  ++ LL +Q L ++ K   ++      LK +
Sbjct: 2028 SEREQQLVEKS---GELLALQKEADSMRADFS-LLRNQFLTERKKAEKQVASLKEALKIQ 2083

Query: 656  VSKLRCQLAKKKQSETKLQEEL 677
             S+L   L ++KQ  + +Q+E+
Sbjct: 2084 RSQLEKNLLEQKQENSCIQKEM 2105



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 125/557 (22%), Positives = 238/557 (42%), Gaps = 54/557 (9%)

Query: 39   QKSQRFKQQKESKQ-NLNVDKDTTLPASARKVKSSESKKESQKN--DKDLKILEKEIRVL 95
            QK +   +QKE K   + +D   +       +K+ +S KE Q +  +K  + LE  +  +
Sbjct: 522  QKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEI 581

Query: 96   LQERGAQDRRIQDLETELEKMEARLNAALREKT------------SLSANNATLEKQLIE 143
            L     +   I+DLE +L + +   N AL++              ++       + +  +
Sbjct: 582  LSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRK 641

Query: 144  LTRTNELLKSKFSENGNQKN-LRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRS 202
            L    E L  + +E   +++ L I++++   +R K   ++   + +Q  +   LQ TQ  
Sbjct: 642  LRDEKETLLQRLTEVEQERDQLEIVAMDAENMR-KELAELESALQEQHEVNASLQQTQGD 700

Query: 203  LEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIE-EISCASDQVEKYK------LDI 255
            L   +   A+LE +L   + E    K E EK+    + E S    ++EK +      L  
Sbjct: 701  LSAYE---AELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGK 757

Query: 256  AQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENL 315
            AQ  E  +++N E+ +  + L+++  +L +Q++D         +   +HV       E +
Sbjct: 758  AQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDF--------QNHLNHVVDGLVRPEEV 809

Query: 316  NAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLF 375
             A +  L++K  L   E       ++   SL   +K+ S  L +      E  V+E+ L 
Sbjct: 810  AARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKL- 868

Query: 376  EEELKQTLDELDKLQQKEEQA-ERLV--------KQLEEEAKSRAEELKLLEEKLKGKE- 425
            +EE+    ++L   Q++  QA ER +        +Q E   +    E+  L+E LK  E 
Sbjct: 869  QEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEE 928

Query: 426  ----AELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSL 481
                 +L+   A   +  +L Q +     + LED  +Q + +      E++ LK   ++ 
Sbjct: 929  IQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGL--DKELKKLKKAVATS 986

Query: 482  QEKAAKAGKNAEDVQHQILATESS-NQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 540
             + A      A+D    +  T    NQE    L + +  S       +++T +  + I  
Sbjct: 987  DKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAE-IEL 1045

Query: 541  LQNQLKQQEEDFRKQLE 557
            LQN L+Q+ E FR ++E
Sbjct: 1046 LQNLLRQKGEQFRLEME 1062



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 155/758 (20%), Positives = 315/758 (41%), Gaps = 94/758 (12%)

Query: 24  YDVKTLEVLKG-PVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKND 82
           + +++LE L+G PV+ Q  Q   ++   ++   +++D       + +++ E K +  +  
Sbjct: 242 FHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDL----EKKMIETEELKSKQTRFL 297

Query: 83  KDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLI 142
           +++K  +K  + L +E   Q +  ++L+++L      L     E T        LE++L 
Sbjct: 298 EEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELA 357

Query: 143 --ELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET---------KMRGMMAKQEG 191
             ++    E L    SE          S  + K R KR             + +  K+  
Sbjct: 358 FYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKME 417

Query: 192 MEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKY 251
            + +L+    +L        QLE      +KEK    ++T +L E  +EI  A  Q+ + 
Sbjct: 418 PDEQLRNDHMNLRGHTPLDTQLE------DKEKKISAAQT-RLSELHDEIEKAEQQILRA 470

Query: 252 KLDIAQLEENLKEKNDEILS---LKQSLEENIVILSK-QVEDLNVKCQLLEKEKEDHVNR 307
             +  QLEE ++ K         L + L   + +++K + E L+++ Q+ EK+K++   +
Sbjct: 471 TEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQM-EKQKQEIAGK 529

Query: 308 NREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEE 367
            +E  + L   + +L  K       + +   KE Q+D + +Q ++L S L + L    +E
Sbjct: 530 QKEIKD-LQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKE 588

Query: 368 MVKEKNLFE----------EELKQTLDE--------LDKLQQKEEQAERLVKQLEEEAKS 409
             + K+L E          E LK+ L+         L  ++ +  QA+   ++L +E ++
Sbjct: 589 TEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKET 648

Query: 410 RAEELKLLEEK-----LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYK 464
             + L  +E++     +   +AE  +   A  ++ L  Q + ++   SL+       +Y+
Sbjct: 649 LLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNA---SLQQTQGDLSAYE 705

Query: 465 ALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKE 524
           A   + +     E + L+E+  K  +  +  Q  + A     ++ ++  L     S  KE
Sbjct: 706 AELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKE 765

Query: 525 TEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRL-- 582
            E  E+    L+ + D  N LKQQ +DF+  L          E   A + E   K +L  
Sbjct: 766 QENSELHAK-LKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGT 824

Query: 583 -----------LYEELYNKTKPF-------QLQLDAFEVEKQALLNEHGAAQEQL----N 620
                      L + L +  K F       + + D  +V ++ L  E    QE+L     
Sbjct: 825 GEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQE 884

Query: 621 KIRDSYAKLL---------GHQNLKQKIKHVVKLKDENSQLKSEVSKLR-CQLAKKKQSE 670
           + R +  + L          H+   Q++++ +    EN +   E+  L   QL +  + +
Sbjct: 885 EFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEK 944

Query: 671 TKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKE 708
            ++  +L ++   K  + +K+     ++ F L   LK+
Sbjct: 945 ERILAQLRELEKKKKLEDAKS----QEQVFGLDKELKK 978



 Score = 30.0 bits (66), Expect = 7.9
 Identities = 26/142 (18%), Positives = 61/142 (42%), Gaps = 14/142 (9%)

Query: 540  DLQNQLKQQEE---DFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQL 596
            +L+N++ + E+     + +  +E   +A K  +  E+           EEL++       
Sbjct: 1320 NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEM-----------EELHHNIDDLLQ 1368

Query: 597  QLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEV 656
            +  + E E + L       Q+Q + I  +   L+    +++ +KH   + DE   ++  +
Sbjct: 1369 EKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTL 1428

Query: 657  SKLRCQLAKKKQSETKLQEELN 678
             K R +L +  +   + + EL+
Sbjct: 1429 LKRRSELREADRLLAEAESELS 1450


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  113 bits (283), Expect = 5e-25
 Identities = 154/722 (21%), Positives = 309/722 (42%), Gaps = 89/722 (12%)

Query: 41   SQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQK--NDKDLKILEKEIR--VLL 96
            SQ  +++   ++ L  + +    A   +V+ +  K+E ++  ++ + ++ E+E R   L 
Sbjct: 883  SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 942

Query: 97   QERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLI-------ELTRTNE 149
             ER    +++ DLE +LE+ EA       EK +  A    LE +++       +L++  +
Sbjct: 943  AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002

Query: 150  LLKSKFSE-NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG 208
            LL+ + S+   N       +  L KL+NK E+ +         +E++L+  ++S +E + 
Sbjct: 1003 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI-------SELEVRLKKEEKSRQELEK 1055

Query: 209  KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDE 268
               +LEG      ++  D +++  +L   +      + + E+ +  +A+L++ + +KN+ 
Sbjct: 1056 LKRKLEGDASDFHEQIADLQAQIAELKMQL------AKKEEELQAALARLDDEIAQKNNA 1109

Query: 269  ILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFIL 328
            +  +++ LE +I  L + ++         EK+K D      E  E L  E+++       
Sbjct: 1110 LKKIRE-LEGHISDLQEDLDSERAARNKAEKQKRD----LGEELEALKTELEDTLDSTAT 1164

Query: 329  EQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDK 388
            +Q+ R K +Q+   +   L +E     +  Q++     + V+E     E+ K+    LDK
Sbjct: 1165 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1224

Query: 389  LQQK-EEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYD 447
             +Q  E++   L  +L    +++ +E++  ++KL+ +  EL+   +   +A   L +K  
Sbjct: 1225 NKQTLEKENADLAGELRVLGQAK-QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1283

Query: 448  SMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQ 507
             +   +E VT                     +  + KA K  K+   +  Q+  T+   Q
Sbjct: 1284 KLQNEVESVTGML------------------NEAEGKAIKLAKDVASLSSQLQDTQELLQ 1325

Query: 508  EYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQN------QLKQQEEDFRKQLED--- 558
            E  R  L++ TK    E E   +     +++   QN       L  Q  D +K+L+D   
Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1385

Query: 559  -----EEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHG 613
                 EEG+K   +     LT++  +    Y++L       Q +LD   V+    L+   
Sbjct: 1386 TVEALEEGKK-RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD----LDNQR 1440

Query: 614  AAQEQLNKIRDSYAKLLGHQ-NLKQKIKHVVKLKDENSQLKSEVSKLRCQ---LAKKKQS 669
                 L K +  + +LL  + N+        K  DE  + ++E  +   +   LA+  + 
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISS------KYADERDRAEAEAREKETKALSLARALEE 1494

Query: 670  ETKLQEEL---NKVLGIK-------HFDPSKAFHHESKENFALKTPLKEGNTNCYRAPME 719
              + +EEL   NK+L  +         D  K  H   K   AL+T ++E  T       E
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554

Query: 720  CQ 721
             Q
Sbjct: 1555 LQ 1556



 Score =  110 bits (275), Expect = 5e-24
 Identities = 137/658 (20%), Positives = 292/658 (44%), Gaps = 50/658 (7%)

Query: 40   KSQRFKQQKESKQNLNVDKDTTLPASARKVKS------SESKKESQKNDKDLKILEKEIR 93
            K ++  +++ S    N+ ++     +  K+K+      SE +   +K +K  + LEK  R
Sbjct: 999  KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1058

Query: 94   VLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKS 153
             L  +      +I DL+ ++ +++ +L    +++  L A  A L+    E+ + N  LK 
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQL---AKKEEELQAALARLDD---EIAQKNNALKK 1112

Query: 154  KFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQL 213
                 G+  +L+         RNK E + R +  + E ++ +L+ T  S    Q   A+ 
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1172

Query: 214  EGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLK 273
            E + V++ K+ +DE++ + +             QV++ +   AQ  E L E+ ++    K
Sbjct: 1173 EQE-VTVLKKALDEETRSHEA------------QVQEMRQKHAQAVEELTEQLEQFKRAK 1219

Query: 274  QSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQER 333
             +L++N   L K+  DL  + ++L + K++  ++ ++    L A++Q L+ K    ++ R
Sbjct: 1220 ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK----LEAQVQELQSKCSDGERAR 1275

Query: 334  -------EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDEL 386
                    KLQ +   +  +L + +  +  L + + S   ++   + L +EE +Q L+  
Sbjct: 1276 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1335

Query: 387  DKLQQKEEQAERLVKQLEE--EAKSRAEE----LKLLEEKLKGKEAELEKSSAAHTQATL 440
             KL+Q EE+   L  QL+E  EAK   E     L +     K K  +   +  A  +   
Sbjct: 1336 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1395

Query: 441  LLQEKYDSMVQSLEDVTAQF---ESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQH 497
              Q++ +++ Q  E+  A +   E  K     E++DL ++  + ++  +   K       
Sbjct: 1396 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455

Query: 498  QILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLE 557
             +   ++ + +Y       + ++  KET+   +  + L++  + + +L++  +  + ++E
Sbjct: 1456 LLAEEKNISSKYADERDRAEAEAREKETKALSLARA-LEEALEAKEELERTNKMLKAEME 1514

Query: 558  DEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE 617
            D    K +      EL +         EE+  + +  + +L A E  K  L     A + 
Sbjct: 1515 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1574

Query: 618  QLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 675
            Q    RD  A+    QN +++ +   +L +  ++L+ E  +     A KK+ E  L++
Sbjct: 1575 QFE--RDLQAR--DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628



 Score =  105 bits (263), Expect = 1e-22
 Identities = 139/662 (20%), Positives = 294/662 (44%), Gaps = 94/662 (14%)

Query: 47   QKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKI-----LEKEIRVLLQERGA 101
            Q+E++Q LNV         + K++  E ++ S ++  D ++     LE+ I  L  +   
Sbjct: 1325 QEETRQKLNV---------STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375

Query: 102  QDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSEN--- 158
              +++QD  + +E +E       +E  +L+           +L +T   L+ +  +    
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435

Query: 159  -GNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKL 217
              NQ+ L + +LE      K++ K   ++A+++ +  K    +R   E++ +  + E K 
Sbjct: 1436 LDNQRQL-VSNLE------KKQRKFDQLLAEEKNISSKY-ADERDRAEAEAR--EKETKA 1485

Query: 218  VSIEK---EKIDEKSETEK----LLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEIL 270
            +S+ +   E ++ K E E+    L   +E++  + D V K   ++ + +  L+ + +E+ 
Sbjct: 1486 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1545

Query: 271  SLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQ 330
            +  + LE+ +         L V  Q L+ + E  +    E NE    ++Q    ++  E 
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1605

Query: 331  QEREKLQ------QKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLD 384
            ++  K +      +K+L+ D L   E +  S++  +     EE +K+    + ++K    
Sbjct: 1606 EDERKQRALAAAAKKKLEGD-LKDLELQADSAIKGR-----EEAIKQLRKLQAQMKDFQR 1659

Query: 385  ELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKG-----KEAELEKSSAAHTQAT 439
            EL+  +   ++     K+ E++AKS   +L  L+E L       K+A+LEK   A   A+
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS 1719

Query: 440  LLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI 499
             L      S   +L+D   + E+  A    E+E+ +    ++ ++  KA + AE + ++ 
Sbjct: 1720 SL------SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE- 1772

Query: 500  LATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDE 559
            LATE S                              QK    + QL++Q ++ R +L + 
Sbjct: 1773 LATERST----------------------------AQKNESARQQLERQNKELRSKLHEM 1804

Query: 560  EGR-KAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQ 618
            EG  K++ ++T A L  +I +   L E++  + +  Q    + + +K   L E     E 
Sbjct: 1805 EGAVKSKFKSTIAALEAKIAQ---LEEQVEQEAREKQAATKSLK-QKDKKLKEILLQVED 1860

Query: 619  LNKIRDSYAKLL--GHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEE 676
              K+ + Y +    G+  +KQ  + + + ++E+ ++ +   KL+ +L +  +S   +  E
Sbjct: 1861 ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1920

Query: 677  LN 678
            +N
Sbjct: 1921 VN 1922



 Score = 86.3 bits (212), Expect = 9e-17
 Identities = 119/536 (22%), Positives = 249/536 (46%), Gaps = 54/536 (10%)

Query: 172  MKLRN----KRETKMRGMMA---KQEGMEMK---LQVTQRSLEESQGKIAQLEGKLVSIE 221
            +KLRN    +  TK++ ++    ++E M+ K   LQ T+   ++++ ++ +LE K   + 
Sbjct: 827  LKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT 886

Query: 222  KEK--IDE--KSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKND---EILSLKQ 274
            +EK  + E  ++ETE   E  E     + + ++ +  + ++E  L+E+ D   ++ + ++
Sbjct: 887  EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK 946

Query: 275  SLEENIVILSKQVEDLNVKCQLLEKEK-EDHVNRNREHNENLNAEMQNLKQKFILEQQER 333
             + + ++ L +Q+E+     Q L+ EK        +  +E L  + QN K       +ER
Sbjct: 947  KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL-----SKER 1001

Query: 334  EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQK- 392
            + L+++   + + L +E+E + +L  KL +  E M+ E  +  ++ +++  EL+KL++K 
Sbjct: 1002 KLLEERISDLTTNLAEEEEKAKNL-TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1060

Query: 393  EEQAERLVKQLEEEAKSRAE---ELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSM 449
            E  A    +Q+ +     AE   +L   EE+L+   A L+   A    A   ++E    +
Sbjct: 1061 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1120

Query: 450  VQSLEDVTAQ------FESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATE 503
                ED+ ++       E  K     E+E LK E     +  A         Q ++ A  
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA--------TQQELRAKR 1172

Query: 504  SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRK 563
                  ++  LD +T+S   E +++E+     Q + +L  QL+Q    F++   + +  K
Sbjct: 1173 EQEVTVLKKALDEETRS--HEAQVQEMRQKHAQAVEELTEQLEQ----FKRAKANLDKNK 1226

Query: 564  AEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQ--EQLNK 621
               E   A+L  E+       +E+ +K K  + Q+   E++ +    E   A+  ++++K
Sbjct: 1227 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ--ELQSKCSDGERARAELNDKVHK 1284

Query: 622  IRDSYAKLLGHQNLKQ--KIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 675
            +++    + G  N  +   IK    +   +SQL+     L+ +  +K    TKL++
Sbjct: 1285 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340



 Score = 83.2 bits (204), Expect = 8e-16
 Identities = 105/509 (20%), Positives = 216/509 (42%), Gaps = 75/509 (14%)

Query: 41   SQRFKQQKESKQNLNVDKDTTLPASARKVKSS-ESKKESQKNDKDLKI-----------L 88
            S ++  +++  +    +K+T   + AR ++ + E+K+E ++ +K LK            +
Sbjct: 1464 SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1523

Query: 89   EKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN 148
             K +  L + + A + ++++++T+LE++E  L A    K  L  N   L+ Q        
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF------E 1577

Query: 149  ELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMA----KQEG----MEMKLQVTQ 200
              L+++  +N  ++      L   +   + E K R + A    K EG    +E++     
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637

Query: 201  RSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEE 260
            +  EE+  ++ +L+ ++   ++E  D ++  +++    +E    +  +E    D+ QL+E
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA---DLMQLQE 1694

Query: 261  NL-------KEKNDEILSLKQSLEENIV---ILSKQVEDLNVKCQLLEKEKEDHVNRNRE 310
            +L       K+ + E   L + L  ++     L  +   L  +   LE+E E+       
Sbjct: 1695 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1754

Query: 311  HNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVK 370
             ++ +    Q  +Q       ER   Q+ E     L +Q KEL S LH+      E  VK
Sbjct: 1755 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE-----MEGAVK 1809

Query: 371  EKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEK 430
             K       K T+  L          E  + QLEE+ +  A E +   + LK K+ +L++
Sbjct: 1810 SK------FKSTIAAL----------EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1853

Query: 431  SSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGK 490
                     +LLQ      V+    +  Q++       + ++ LK +    +E++ +   
Sbjct: 1854 ---------ILLQ------VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898

Query: 491  NAEDVQHQILATESSNQEYVRMLLDLQTK 519
            N   +Q ++     SN+   R +  L++K
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNALKSK 1927



 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 82/336 (24%), Positives = 154/336 (45%), Gaps = 32/336 (9%)

Query: 376  EEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAH 435
            EEE++   DEL K ++++++AE  +K+LE++     EE  LL+E+L   +AE E  + A 
Sbjct: 851  EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL---QAETELYAEAE 907

Query: 436  TQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDV 495
                 L  +K     Q LE++  + E       + +E+ +     LQ +  K  +   D+
Sbjct: 908  EMRVRLAAKK-----QELEEILHEME-------ARLEEEEDRGQQLQAERKKMAQQMLDL 955

Query: 496  QHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQ 555
            + Q+   E++ Q+       LQ +    E +IK++    L  + D  N+L ++ +   ++
Sbjct: 956  EEQLEEEEAARQK-------LQLEKVTAEAKIKKLEDEIL-VMDDQNNKLSKERKLLEER 1007

Query: 556  LEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAA 615
            + D     AE+E     LT+  NK   +  EL  + K  +      E  K+ L  +    
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067

Query: 616  QEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSE---TK 672
             EQ+  ++   A+L       Q  K   +L+   ++L  E+++    L K ++ E   + 
Sbjct: 1068 HEQIADLQAQIAEL-----KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1122

Query: 673  LQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKE 708
            LQE+L+     ++    K      +E  ALKT L++
Sbjct: 1123 LQEDLDSERAARN-KAEKQKRDLGEELEALKTELED 1157



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 93/420 (22%), Positives = 192/420 (45%), Gaps = 50/420 (11%)

Query: 301  KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 360
            KED + + +E  +    E++ L+QK   +  E + L Q++LQ ++ L  E E    +  +
Sbjct: 857  KEDELQKTKERQQKAENELKELEQKHS-QLTEEKNLLQEQLQAETELYAEAE---EMRVR 912

Query: 361  LCSFQEEMVKEKNLFEEELKQTLDELDKLQ-QKEEQAERLV---KQLEEEAKSRAEELKL 416
            L + ++E+ +  +  E  L++  D   +LQ ++++ A++++   +QLEEE  +R ++L+L
Sbjct: 913  LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR-QKLQL 971

Query: 417  LEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQF--ESYKALTASEIEDL 474
             +   + K  +LE            L ++   + + + D+T     E  KA   +++++ 
Sbjct: 972  EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN- 1030

Query: 475  KLEN--SSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQT-------KSALKET 525
            K E+  S L+ +  K  K+ ++++      E    ++   + DLQ        + A KE 
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1090

Query: 526  EIKEITVSFLQKITDLQNQLKQQEE------DFRKQLEDEEGRKAEKENTTAELTEEINK 579
            E++        +I    N LK+  E      D ++ L+ E   + + E    +L EE+  
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150

Query: 580  WRLLYEELYNKTKPFQLQLDA-----FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQN 634
             +   E+  + T   Q +L A       V K+AL  E  + + Q+ ++R  +A+ +  + 
Sbjct: 1151 LKTELEDTLDSTAT-QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV--EE 1207

Query: 635  LKQKIKHVVKLKDENSQLKSEVSKLRCQLA---------------KKKQSETKLQEELNK 679
            L ++++   + K    + K  + K    LA               KKK+ E ++QE  +K
Sbjct: 1208 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1267


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  113 bits (283), Expect = 5e-25
 Identities = 154/722 (21%), Positives = 309/722 (42%), Gaps = 89/722 (12%)

Query: 41   SQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQK--NDKDLKILEKEIR--VLL 96
            SQ  +++   ++ L  + +    A   +V+ +  K+E ++  ++ + ++ E+E R   L 
Sbjct: 890  SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 949

Query: 97   QERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLI-------ELTRTNE 149
             ER    +++ DLE +LE+ EA       EK +  A    LE +++       +L++  +
Sbjct: 950  AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009

Query: 150  LLKSKFSE-NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG 208
            LL+ + S+   N       +  L KL+NK E+ +         +E++L+  ++S +E + 
Sbjct: 1010 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI-------SELEVRLKKEEKSRQELEK 1062

Query: 209  KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDE 268
               +LEG      ++  D +++  +L   +      + + E+ +  +A+L++ + +KN+ 
Sbjct: 1063 LKRKLEGDASDFHEQIADLQAQIAELKMQL------AKKEEELQAALARLDDEIAQKNNA 1116

Query: 269  ILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFIL 328
            +  +++ LE +I  L + ++         EK+K D      E  E L  E+++       
Sbjct: 1117 LKKIRE-LEGHISDLQEDLDSERAARNKAEKQKRD----LGEELEALKTELEDTLDSTAT 1171

Query: 329  EQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDK 388
            +Q+ R K +Q+   +   L +E     +  Q++     + V+E     E+ K+    LDK
Sbjct: 1172 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231

Query: 389  LQQK-EEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYD 447
             +Q  E++   L  +L    +++ +E++  ++KL+ +  EL+   +   +A   L +K  
Sbjct: 1232 NKQTLEKENADLAGELRVLGQAK-QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1290

Query: 448  SMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQ 507
             +   +E VT                     +  + KA K  K+   +  Q+  T+   Q
Sbjct: 1291 KLQNEVESVTGML------------------NEAEGKAIKLAKDVASLSSQLQDTQELLQ 1332

Query: 508  EYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQN------QLKQQEEDFRKQLED--- 558
            E  R  L++ TK    E E   +     +++   QN       L  Q  D +K+L+D   
Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1392

Query: 559  -----EEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHG 613
                 EEG+K   +     LT++  +    Y++L       Q +LD   V+    L+   
Sbjct: 1393 TVEALEEGKK-RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD----LDNQR 1447

Query: 614  AAQEQLNKIRDSYAKLLGHQ-NLKQKIKHVVKLKDENSQLKSEVSKLRCQ---LAKKKQS 669
                 L K +  + +LL  + N+        K  DE  + ++E  +   +   LA+  + 
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEKNISS------KYADERDRAEAEAREKETKALSLARALEE 1501

Query: 670  ETKLQEEL---NKVLGIK-------HFDPSKAFHHESKENFALKTPLKEGNTNCYRAPME 719
              + +EEL   NK+L  +         D  K  H   K   AL+T ++E  T       E
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561

Query: 720  CQ 721
             Q
Sbjct: 1562 LQ 1563



 Score =  110 bits (275), Expect = 5e-24
 Identities = 137/658 (20%), Positives = 292/658 (44%), Gaps = 50/658 (7%)

Query: 40   KSQRFKQQKESKQNLNVDKDTTLPASARKVKS------SESKKESQKNDKDLKILEKEIR 93
            K ++  +++ S    N+ ++     +  K+K+      SE +   +K +K  + LEK  R
Sbjct: 1006 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1065

Query: 94   VLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKS 153
             L  +      +I DL+ ++ +++ +L    +++  L A  A L+    E+ + N  LK 
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQL---AKKEEELQAALARLDD---EIAQKNNALKK 1119

Query: 154  KFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQL 213
                 G+  +L+         RNK E + R +  + E ++ +L+ T  S    Q   A+ 
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1179

Query: 214  EGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLK 273
            E + V++ K+ +DE++ + +             QV++ +   AQ  E L E+ ++    K
Sbjct: 1180 EQE-VTVLKKALDEETRSHEA------------QVQEMRQKHAQAVEELTEQLEQFKRAK 1226

Query: 274  QSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQER 333
             +L++N   L K+  DL  + ++L + K++  ++ ++    L A++Q L+ K    ++ R
Sbjct: 1227 ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK----LEAQVQELQSKCSDGERAR 1282

Query: 334  -------EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDEL 386
                    KLQ +   +  +L + +  +  L + + S   ++   + L +EE +Q L+  
Sbjct: 1283 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1342

Query: 387  DKLQQKEEQAERLVKQLEE--EAKSRAEE----LKLLEEKLKGKEAELEKSSAAHTQATL 440
             KL+Q EE+   L  QL+E  EAK   E     L +     K K  +   +  A  +   
Sbjct: 1343 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1402

Query: 441  LLQEKYDSMVQSLEDVTAQF---ESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQH 497
              Q++ +++ Q  E+  A +   E  K     E++DL ++  + ++  +   K       
Sbjct: 1403 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462

Query: 498  QILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLE 557
             +   ++ + +Y       + ++  KET+   +  + L++  + + +L++  +  + ++E
Sbjct: 1463 LLAEEKNISSKYADERDRAEAEAREKETKALSLARA-LEEALEAKEELERTNKMLKAEME 1521

Query: 558  DEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE 617
            D    K +      EL +         EE+  + +  + +L A E  K  L     A + 
Sbjct: 1522 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1581

Query: 618  QLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 675
            Q    RD  A+    QN +++ +   +L +  ++L+ E  +     A KK+ E  L++
Sbjct: 1582 QFE--RDLQAR--DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635



 Score =  105 bits (263), Expect = 1e-22
 Identities = 139/662 (20%), Positives = 294/662 (44%), Gaps = 94/662 (14%)

Query: 47   QKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKI-----LEKEIRVLLQERGA 101
            Q+E++Q LNV         + K++  E ++ S ++  D ++     LE+ I  L  +   
Sbjct: 1332 QEETRQKLNV---------STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382

Query: 102  QDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSEN--- 158
              +++QD  + +E +E       +E  +L+           +L +T   L+ +  +    
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442

Query: 159  -GNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKL 217
              NQ+ L + +LE      K++ K   ++A+++ +  K    +R   E++ +  + E K 
Sbjct: 1443 LDNQRQL-VSNLE------KKQRKFDQLLAEEKNISSKY-ADERDRAEAEAR--EKETKA 1492

Query: 218  VSIEK---EKIDEKSETEK----LLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEIL 270
            +S+ +   E ++ K E E+    L   +E++  + D V K   ++ + +  L+ + +E+ 
Sbjct: 1493 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1552

Query: 271  SLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQ 330
            +  + LE+ +         L V  Q L+ + E  +    E NE    ++Q    ++  E 
Sbjct: 1553 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1612

Query: 331  QEREKLQ------QKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLD 384
            ++  K +      +K+L+ D L   E +  S++  +     EE +K+    + ++K    
Sbjct: 1613 EDERKQRALAAAAKKKLEGD-LKDLELQADSAIKGR-----EEAIKQLRKLQAQMKDFQR 1666

Query: 385  ELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKG-----KEAELEKSSAAHTQAT 439
            EL+  +   ++     K+ E++AKS   +L  L+E L       K+A+LEK   A   A+
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS 1726

Query: 440  LLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI 499
             L      S   +L+D   + E+  A    E+E+ +    ++ ++  KA + AE + ++ 
Sbjct: 1727 SL------SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE- 1779

Query: 500  LATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDE 559
            LATE S                              QK    + QL++Q ++ R +L + 
Sbjct: 1780 LATERST----------------------------AQKNESARQQLERQNKELRSKLHEM 1811

Query: 560  EGR-KAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQ 618
            EG  K++ ++T A L  +I +   L E++  + +  Q    + + +K   L E     E 
Sbjct: 1812 EGAVKSKFKSTIAALEAKIAQ---LEEQVEQEAREKQAATKSLK-QKDKKLKEILLQVED 1867

Query: 619  LNKIRDSYAKLL--GHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEE 676
              K+ + Y +    G+  +KQ  + + + ++E+ ++ +   KL+ +L +  +S   +  E
Sbjct: 1868 ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1927

Query: 677  LN 678
            +N
Sbjct: 1928 VN 1929



 Score = 86.3 bits (212), Expect = 9e-17
 Identities = 119/536 (22%), Positives = 249/536 (46%), Gaps = 54/536 (10%)

Query: 172  MKLRN----KRETKMRGMMA---KQEGMEMK---LQVTQRSLEESQGKIAQLEGKLVSIE 221
            +KLRN    +  TK++ ++    ++E M+ K   LQ T+   ++++ ++ +LE K   + 
Sbjct: 834  LKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT 893

Query: 222  KEK--IDE--KSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKND---EILSLKQ 274
            +EK  + E  ++ETE   E  E     + + ++ +  + ++E  L+E+ D   ++ + ++
Sbjct: 894  EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK 953

Query: 275  SLEENIVILSKQVEDLNVKCQLLEKEK-EDHVNRNREHNENLNAEMQNLKQKFILEQQER 333
             + + ++ L +Q+E+     Q L+ EK        +  +E L  + QN K       +ER
Sbjct: 954  KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL-----SKER 1008

Query: 334  EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQK- 392
            + L+++   + + L +E+E + +L  KL +  E M+ E  +  ++ +++  EL+KL++K 
Sbjct: 1009 KLLEERISDLTTNLAEEEEKAKNL-TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1067

Query: 393  EEQAERLVKQLEEEAKSRAE---ELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSM 449
            E  A    +Q+ +     AE   +L   EE+L+   A L+   A    A   ++E    +
Sbjct: 1068 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1127

Query: 450  VQSLEDVTAQ------FESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATE 503
                ED+ ++       E  K     E+E LK E     +  A         Q ++ A  
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA--------TQQELRAKR 1179

Query: 504  SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRK 563
                  ++  LD +T+S   E +++E+     Q + +L  QL+Q    F++   + +  K
Sbjct: 1180 EQEVTVLKKALDEETRS--HEAQVQEMRQKHAQAVEELTEQLEQ----FKRAKANLDKNK 1233

Query: 564  AEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQ--EQLNK 621
               E   A+L  E+       +E+ +K K  + Q+   E++ +    E   A+  ++++K
Sbjct: 1234 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ--ELQSKCSDGERARAELNDKVHK 1291

Query: 622  IRDSYAKLLGHQNLKQ--KIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 675
            +++    + G  N  +   IK    +   +SQL+     L+ +  +K    TKL++
Sbjct: 1292 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347



 Score = 83.2 bits (204), Expect = 8e-16
 Identities = 105/509 (20%), Positives = 216/509 (42%), Gaps = 75/509 (14%)

Query: 41   SQRFKQQKESKQNLNVDKDTTLPASARKVKSS-ESKKESQKNDKDLKI-----------L 88
            S ++  +++  +    +K+T   + AR ++ + E+K+E ++ +K LK            +
Sbjct: 1471 SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1530

Query: 89   EKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN 148
             K +  L + + A + ++++++T+LE++E  L A    K  L  N   L+ Q        
Sbjct: 1531 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF------E 1584

Query: 149  ELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMA----KQEG----MEMKLQVTQ 200
              L+++  +N  ++      L   +   + E K R + A    K EG    +E++     
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644

Query: 201  RSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEE 260
            +  EE+  ++ +L+ ++   ++E  D ++  +++    +E    +  +E    D+ QL+E
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA---DLMQLQE 1701

Query: 261  NL-------KEKNDEILSLKQSLEENIV---ILSKQVEDLNVKCQLLEKEKEDHVNRNRE 310
            +L       K+ + E   L + L  ++     L  +   L  +   LE+E E+       
Sbjct: 1702 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1761

Query: 311  HNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVK 370
             ++ +    Q  +Q       ER   Q+ E     L +Q KEL S LH+      E  VK
Sbjct: 1762 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE-----MEGAVK 1816

Query: 371  EKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEK 430
             K       K T+  L          E  + QLEE+ +  A E +   + LK K+ +L++
Sbjct: 1817 SK------FKSTIAAL----------EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1860

Query: 431  SSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGK 490
                     +LLQ      V+    +  Q++       + ++ LK +    +E++ +   
Sbjct: 1861 ---------ILLQ------VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905

Query: 491  NAEDVQHQILATESSNQEYVRMLLDLQTK 519
            N   +Q ++     SN+   R +  L++K
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNALKSK 1934



 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 82/336 (24%), Positives = 154/336 (45%), Gaps = 32/336 (9%)

Query: 376  EEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAH 435
            EEE++   DEL K ++++++AE  +K+LE++     EE  LL+E+L   +AE E  + A 
Sbjct: 858  EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL---QAETELYAEAE 914

Query: 436  TQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDV 495
                 L  +K     Q LE++  + E       + +E+ +     LQ +  K  +   D+
Sbjct: 915  EMRVRLAAKK-----QELEEILHEME-------ARLEEEEDRGQQLQAERKKMAQQMLDL 962

Query: 496  QHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQ 555
            + Q+   E++ Q+       LQ +    E +IK++    L  + D  N+L ++ +   ++
Sbjct: 963  EEQLEEEEAARQK-------LQLEKVTAEAKIKKLEDEIL-VMDDQNNKLSKERKLLEER 1014

Query: 556  LEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAA 615
            + D     AE+E     LT+  NK   +  EL  + K  +      E  K+ L  +    
Sbjct: 1015 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074

Query: 616  QEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSE---TK 672
             EQ+  ++   A+L       Q  K   +L+   ++L  E+++    L K ++ E   + 
Sbjct: 1075 HEQIADLQAQIAEL-----KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1129

Query: 673  LQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKE 708
            LQE+L+     ++    K      +E  ALKT L++
Sbjct: 1130 LQEDLDSERAARN-KAEKQKRDLGEELEALKTELED 1164



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 93/420 (22%), Positives = 192/420 (45%), Gaps = 50/420 (11%)

Query: 301  KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 360
            KED + + +E  +    E++ L+QK   +  E + L Q++LQ ++ L  E E    +  +
Sbjct: 864  KEDELQKTKERQQKAENELKELEQKHS-QLTEEKNLLQEQLQAETELYAEAE---EMRVR 919

Query: 361  LCSFQEEMVKEKNLFEEELKQTLDELDKLQ-QKEEQAERLV---KQLEEEAKSRAEELKL 416
            L + ++E+ +  +  E  L++  D   +LQ ++++ A++++   +QLEEE  +R ++L+L
Sbjct: 920  LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR-QKLQL 978

Query: 417  LEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQF--ESYKALTASEIEDL 474
             +   + K  +LE            L ++   + + + D+T     E  KA   +++++ 
Sbjct: 979  EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN- 1037

Query: 475  KLEN--SSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQT-------KSALKET 525
            K E+  S L+ +  K  K+ ++++      E    ++   + DLQ        + A KE 
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1097

Query: 526  EIKEITVSFLQKITDLQNQLKQQEE------DFRKQLEDEEGRKAEKENTTAELTEEINK 579
            E++        +I    N LK+  E      D ++ L+ E   + + E    +L EE+  
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157

Query: 580  WRLLYEELYNKTKPFQLQLDA-----FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQN 634
             +   E+  + T   Q +L A       V K+AL  E  + + Q+ ++R  +A+ +  + 
Sbjct: 1158 LKTELEDTLDSTAT-QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV--EE 1214

Query: 635  LKQKIKHVVKLKDENSQLKSEVSKLRCQLA---------------KKKQSETKLQEELNK 679
            L ++++   + K    + K  + K    LA               KKK+ E ++QE  +K
Sbjct: 1215 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1274


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  113 bits (283), Expect = 5e-25
 Identities = 154/722 (21%), Positives = 309/722 (42%), Gaps = 89/722 (12%)

Query: 41   SQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQK--NDKDLKILEKEIR--VLL 96
            SQ  +++   ++ L  + +    A   +V+ +  K+E ++  ++ + ++ E+E R   L 
Sbjct: 890  SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 949

Query: 97   QERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLI-------ELTRTNE 149
             ER    +++ DLE +LE+ EA       EK +  A    LE +++       +L++  +
Sbjct: 950  AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009

Query: 150  LLKSKFSE-NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG 208
            LL+ + S+   N       +  L KL+NK E+ +         +E++L+  ++S +E + 
Sbjct: 1010 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI-------SELEVRLKKEEKSRQELEK 1062

Query: 209  KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDE 268
               +LEG      ++  D +++  +L   +      + + E+ +  +A+L++ + +KN+ 
Sbjct: 1063 LKRKLEGDASDFHEQIADLQAQIAELKMQL------AKKEEELQAALARLDDEIAQKNNA 1116

Query: 269  ILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFIL 328
            +  +++ LE +I  L + ++         EK+K D      E  E L  E+++       
Sbjct: 1117 LKKIRE-LEGHISDLQEDLDSERAARNKAEKQKRD----LGEELEALKTELEDTLDSTAT 1171

Query: 329  EQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDK 388
            +Q+ R K +Q+   +   L +E     +  Q++     + V+E     E+ K+    LDK
Sbjct: 1172 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231

Query: 389  LQQK-EEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYD 447
             +Q  E++   L  +L    +++ +E++  ++KL+ +  EL+   +   +A   L +K  
Sbjct: 1232 NKQTLEKENADLAGELRVLGQAK-QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1290

Query: 448  SMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQ 507
             +   +E VT                     +  + KA K  K+   +  Q+  T+   Q
Sbjct: 1291 KLQNEVESVTGML------------------NEAEGKAIKLAKDVASLSSQLQDTQELLQ 1332

Query: 508  EYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQN------QLKQQEEDFRKQLED--- 558
            E  R  L++ TK    E E   +     +++   QN       L  Q  D +K+L+D   
Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1392

Query: 559  -----EEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHG 613
                 EEG+K   +     LT++  +    Y++L       Q +LD   V+    L+   
Sbjct: 1393 TVEALEEGKK-RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD----LDNQR 1447

Query: 614  AAQEQLNKIRDSYAKLLGHQ-NLKQKIKHVVKLKDENSQLKSEVSKLRCQ---LAKKKQS 669
                 L K +  + +LL  + N+        K  DE  + ++E  +   +   LA+  + 
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEKNISS------KYADERDRAEAEAREKETKALSLARALEE 1501

Query: 670  ETKLQEEL---NKVLGIK-------HFDPSKAFHHESKENFALKTPLKEGNTNCYRAPME 719
              + +EEL   NK+L  +         D  K  H   K   AL+T ++E  T       E
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561

Query: 720  CQ 721
             Q
Sbjct: 1562 LQ 1563



 Score =  110 bits (275), Expect = 5e-24
 Identities = 137/658 (20%), Positives = 292/658 (44%), Gaps = 50/658 (7%)

Query: 40   KSQRFKQQKESKQNLNVDKDTTLPASARKVKS------SESKKESQKNDKDLKILEKEIR 93
            K ++  +++ S    N+ ++     +  K+K+      SE +   +K +K  + LEK  R
Sbjct: 1006 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1065

Query: 94   VLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKS 153
             L  +      +I DL+ ++ +++ +L    +++  L A  A L+    E+ + N  LK 
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQL---AKKEEELQAALARLDD---EIAQKNNALKK 1119

Query: 154  KFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQL 213
                 G+  +L+         RNK E + R +  + E ++ +L+ T  S    Q   A+ 
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1179

Query: 214  EGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLK 273
            E + V++ K+ +DE++ + +             QV++ +   AQ  E L E+ ++    K
Sbjct: 1180 EQE-VTVLKKALDEETRSHEA------------QVQEMRQKHAQAVEELTEQLEQFKRAK 1226

Query: 274  QSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQER 333
             +L++N   L K+  DL  + ++L + K++  ++ ++    L A++Q L+ K    ++ R
Sbjct: 1227 ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK----LEAQVQELQSKCSDGERAR 1282

Query: 334  -------EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDEL 386
                    KLQ +   +  +L + +  +  L + + S   ++   + L +EE +Q L+  
Sbjct: 1283 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1342

Query: 387  DKLQQKEEQAERLVKQLEE--EAKSRAEE----LKLLEEKLKGKEAELEKSSAAHTQATL 440
             KL+Q EE+   L  QL+E  EAK   E     L +     K K  +   +  A  +   
Sbjct: 1343 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1402

Query: 441  LLQEKYDSMVQSLEDVTAQF---ESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQH 497
              Q++ +++ Q  E+  A +   E  K     E++DL ++  + ++  +   K       
Sbjct: 1403 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462

Query: 498  QILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLE 557
             +   ++ + +Y       + ++  KET+   +  + L++  + + +L++  +  + ++E
Sbjct: 1463 LLAEEKNISSKYADERDRAEAEAREKETKALSLARA-LEEALEAKEELERTNKMLKAEME 1521

Query: 558  DEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE 617
            D    K +      EL +         EE+  + +  + +L A E  K  L     A + 
Sbjct: 1522 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1581

Query: 618  QLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 675
            Q    RD  A+    QN +++ +   +L +  ++L+ E  +     A KK+ E  L++
Sbjct: 1582 QFE--RDLQAR--DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635



 Score =  105 bits (263), Expect = 1e-22
 Identities = 139/662 (20%), Positives = 294/662 (44%), Gaps = 94/662 (14%)

Query: 47   QKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKI-----LEKEIRVLLQERGA 101
            Q+E++Q LNV         + K++  E ++ S ++  D ++     LE+ I  L  +   
Sbjct: 1332 QEETRQKLNV---------STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382

Query: 102  QDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSEN--- 158
              +++QD  + +E +E       +E  +L+           +L +T   L+ +  +    
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442

Query: 159  -GNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKL 217
              NQ+ L + +LE      K++ K   ++A+++ +  K    +R   E++ +  + E K 
Sbjct: 1443 LDNQRQL-VSNLE------KKQRKFDQLLAEEKNISSKY-ADERDRAEAEAR--EKETKA 1492

Query: 218  VSIEK---EKIDEKSETEK----LLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEIL 270
            +S+ +   E ++ K E E+    L   +E++  + D V K   ++ + +  L+ + +E+ 
Sbjct: 1493 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1552

Query: 271  SLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQ 330
            +  + LE+ +         L V  Q L+ + E  +    E NE    ++Q    ++  E 
Sbjct: 1553 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1612

Query: 331  QEREKLQ------QKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLD 384
            ++  K +      +K+L+ D L   E +  S++  +     EE +K+    + ++K    
Sbjct: 1613 EDERKQRALAAAAKKKLEGD-LKDLELQADSAIKGR-----EEAIKQLRKLQAQMKDFQR 1666

Query: 385  ELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKG-----KEAELEKSSAAHTQAT 439
            EL+  +   ++     K+ E++AKS   +L  L+E L       K+A+LEK   A   A+
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS 1726

Query: 440  LLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI 499
             L      S   +L+D   + E+  A    E+E+ +    ++ ++  KA + AE + ++ 
Sbjct: 1727 SL------SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE- 1779

Query: 500  LATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDE 559
            LATE S                              QK    + QL++Q ++ R +L + 
Sbjct: 1780 LATERST----------------------------AQKNESARQQLERQNKELRSKLHEM 1811

Query: 560  EGR-KAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQ 618
            EG  K++ ++T A L  +I +   L E++  + +  Q    + + +K   L E     E 
Sbjct: 1812 EGAVKSKFKSTIAALEAKIAQ---LEEQVEQEAREKQAATKSLK-QKDKKLKEILLQVED 1867

Query: 619  LNKIRDSYAKLL--GHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEE 676
              K+ + Y +    G+  +KQ  + + + ++E+ ++ +   KL+ +L +  +S   +  E
Sbjct: 1868 ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1927

Query: 677  LN 678
            +N
Sbjct: 1928 VN 1929



 Score = 86.3 bits (212), Expect = 9e-17
 Identities = 119/536 (22%), Positives = 249/536 (46%), Gaps = 54/536 (10%)

Query: 172  MKLRN----KRETKMRGMMA---KQEGMEMK---LQVTQRSLEESQGKIAQLEGKLVSIE 221
            +KLRN    +  TK++ ++    ++E M+ K   LQ T+   ++++ ++ +LE K   + 
Sbjct: 834  LKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT 893

Query: 222  KEK--IDE--KSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKND---EILSLKQ 274
            +EK  + E  ++ETE   E  E     + + ++ +  + ++E  L+E+ D   ++ + ++
Sbjct: 894  EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK 953

Query: 275  SLEENIVILSKQVEDLNVKCQLLEKEK-EDHVNRNREHNENLNAEMQNLKQKFILEQQER 333
             + + ++ L +Q+E+     Q L+ EK        +  +E L  + QN K       +ER
Sbjct: 954  KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL-----SKER 1008

Query: 334  EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQK- 392
            + L+++   + + L +E+E + +L  KL +  E M+ E  +  ++ +++  EL+KL++K 
Sbjct: 1009 KLLEERISDLTTNLAEEEEKAKNL-TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1067

Query: 393  EEQAERLVKQLEEEAKSRAE---ELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSM 449
            E  A    +Q+ +     AE   +L   EE+L+   A L+   A    A   ++E    +
Sbjct: 1068 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1127

Query: 450  VQSLEDVTAQ------FESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATE 503
                ED+ ++       E  K     E+E LK E     +  A         Q ++ A  
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA--------TQQELRAKR 1179

Query: 504  SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRK 563
                  ++  LD +T+S   E +++E+     Q + +L  QL+Q    F++   + +  K
Sbjct: 1180 EQEVTVLKKALDEETRS--HEAQVQEMRQKHAQAVEELTEQLEQ----FKRAKANLDKNK 1233

Query: 564  AEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQ--EQLNK 621
               E   A+L  E+       +E+ +K K  + Q+   E++ +    E   A+  ++++K
Sbjct: 1234 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ--ELQSKCSDGERARAELNDKVHK 1291

Query: 622  IRDSYAKLLGHQNLKQ--KIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 675
            +++    + G  N  +   IK    +   +SQL+     L+ +  +K    TKL++
Sbjct: 1292 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347



 Score = 83.2 bits (204), Expect = 8e-16
 Identities = 105/509 (20%), Positives = 216/509 (42%), Gaps = 75/509 (14%)

Query: 41   SQRFKQQKESKQNLNVDKDTTLPASARKVKSS-ESKKESQKNDKDLKI-----------L 88
            S ++  +++  +    +K+T   + AR ++ + E+K+E ++ +K LK            +
Sbjct: 1471 SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1530

Query: 89   EKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN 148
             K +  L + + A + ++++++T+LE++E  L A    K  L  N   L+ Q        
Sbjct: 1531 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF------E 1584

Query: 149  ELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMA----KQEG----MEMKLQVTQ 200
              L+++  +N  ++      L   +   + E K R + A    K EG    +E++     
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644

Query: 201  RSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEE 260
            +  EE+  ++ +L+ ++   ++E  D ++  +++    +E    +  +E    D+ QL+E
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA---DLMQLQE 1701

Query: 261  NL-------KEKNDEILSLKQSLEENIV---ILSKQVEDLNVKCQLLEKEKEDHVNRNRE 310
            +L       K+ + E   L + L  ++     L  +   L  +   LE+E E+       
Sbjct: 1702 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1761

Query: 311  HNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVK 370
             ++ +    Q  +Q       ER   Q+ E     L +Q KEL S LH+      E  VK
Sbjct: 1762 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE-----MEGAVK 1816

Query: 371  EKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEK 430
             K       K T+  L          E  + QLEE+ +  A E +   + LK K+ +L++
Sbjct: 1817 SK------FKSTIAAL----------EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1860

Query: 431  SSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGK 490
                     +LLQ      V+    +  Q++       + ++ LK +    +E++ +   
Sbjct: 1861 ---------ILLQ------VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905

Query: 491  NAEDVQHQILATESSNQEYVRMLLDLQTK 519
            N   +Q ++     SN+   R +  L++K
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNALKSK 1934



 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 82/336 (24%), Positives = 154/336 (45%), Gaps = 32/336 (9%)

Query: 376  EEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAH 435
            EEE++   DEL K ++++++AE  +K+LE++     EE  LL+E+L   +AE E  + A 
Sbjct: 858  EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL---QAETELYAEAE 914

Query: 436  TQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDV 495
                 L  +K     Q LE++  + E       + +E+ +     LQ +  K  +   D+
Sbjct: 915  EMRVRLAAKK-----QELEEILHEME-------ARLEEEEDRGQQLQAERKKMAQQMLDL 962

Query: 496  QHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQ 555
            + Q+   E++ Q+       LQ +    E +IK++    L  + D  N+L ++ +   ++
Sbjct: 963  EEQLEEEEAARQK-------LQLEKVTAEAKIKKLEDEIL-VMDDQNNKLSKERKLLEER 1014

Query: 556  LEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAA 615
            + D     AE+E     LT+  NK   +  EL  + K  +      E  K+ L  +    
Sbjct: 1015 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074

Query: 616  QEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSE---TK 672
             EQ+  ++   A+L       Q  K   +L+   ++L  E+++    L K ++ E   + 
Sbjct: 1075 HEQIADLQAQIAEL-----KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1129

Query: 673  LQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKE 708
            LQE+L+     ++    K      +E  ALKT L++
Sbjct: 1130 LQEDLDSERAARN-KAEKQKRDLGEELEALKTELED 1164



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 93/420 (22%), Positives = 192/420 (45%), Gaps = 50/420 (11%)

Query: 301  KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 360
            KED + + +E  +    E++ L+QK   +  E + L Q++LQ ++ L  E E    +  +
Sbjct: 864  KEDELQKTKERQQKAENELKELEQKHS-QLTEEKNLLQEQLQAETELYAEAE---EMRVR 919

Query: 361  LCSFQEEMVKEKNLFEEELKQTLDELDKLQ-QKEEQAERLV---KQLEEEAKSRAEELKL 416
            L + ++E+ +  +  E  L++  D   +LQ ++++ A++++   +QLEEE  +R ++L+L
Sbjct: 920  LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR-QKLQL 978

Query: 417  LEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQF--ESYKALTASEIEDL 474
             +   + K  +LE            L ++   + + + D+T     E  KA   +++++ 
Sbjct: 979  EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN- 1037

Query: 475  KLEN--SSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQT-------KSALKET 525
            K E+  S L+ +  K  K+ ++++      E    ++   + DLQ        + A KE 
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1097

Query: 526  EIKEITVSFLQKITDLQNQLKQQEE------DFRKQLEDEEGRKAEKENTTAELTEEINK 579
            E++        +I    N LK+  E      D ++ L+ E   + + E    +L EE+  
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157

Query: 580  WRLLYEELYNKTKPFQLQLDA-----FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQN 634
             +   E+  + T   Q +L A       V K+AL  E  + + Q+ ++R  +A+ +  + 
Sbjct: 1158 LKTELEDTLDSTAT-QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV--EE 1214

Query: 635  LKQKIKHVVKLKDENSQLKSEVSKLRCQLA---------------KKKQSETKLQEELNK 679
            L ++++   + K    + K  + K    LA               KKK+ E ++QE  +K
Sbjct: 1215 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1274


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  113 bits (283), Expect = 5e-25
 Identities = 154/722 (21%), Positives = 309/722 (42%), Gaps = 89/722 (12%)

Query: 41   SQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQK--NDKDLKILEKEIR--VLL 96
            SQ  +++   ++ L  + +    A   +V+ +  K+E ++  ++ + ++ E+E R   L 
Sbjct: 883  SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 942

Query: 97   QERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLI-------ELTRTNE 149
             ER    +++ DLE +LE+ EA       EK +  A    LE +++       +L++  +
Sbjct: 943  AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002

Query: 150  LLKSKFSE-NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG 208
            LL+ + S+   N       +  L KL+NK E+ +         +E++L+  ++S +E + 
Sbjct: 1003 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI-------SELEVRLKKEEKSRQELEK 1055

Query: 209  KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDE 268
               +LEG      ++  D +++  +L   +      + + E+ +  +A+L++ + +KN+ 
Sbjct: 1056 LKRKLEGDASDFHEQIADLQAQIAELKMQL------AKKEEELQAALARLDDEIAQKNNA 1109

Query: 269  ILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFIL 328
            +  +++ LE +I  L + ++         EK+K D      E  E L  E+++       
Sbjct: 1110 LKKIRE-LEGHISDLQEDLDSERAARNKAEKQKRD----LGEELEALKTELEDTLDSTAT 1164

Query: 329  EQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDK 388
            +Q+ R K +Q+   +   L +E     +  Q++     + V+E     E+ K+    LDK
Sbjct: 1165 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1224

Query: 389  LQQK-EEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYD 447
             +Q  E++   L  +L    +++ +E++  ++KL+ +  EL+   +   +A   L +K  
Sbjct: 1225 NKQTLEKENADLAGELRVLGQAK-QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1283

Query: 448  SMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQ 507
             +   +E VT                     +  + KA K  K+   +  Q+  T+   Q
Sbjct: 1284 KLQNEVESVTGML------------------NEAEGKAIKLAKDVASLSSQLQDTQELLQ 1325

Query: 508  EYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQN------QLKQQEEDFRKQLED--- 558
            E  R  L++ TK    E E   +     +++   QN       L  Q  D +K+L+D   
Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1385

Query: 559  -----EEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHG 613
                 EEG+K   +     LT++  +    Y++L       Q +LD   V+    L+   
Sbjct: 1386 TVEALEEGKK-RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD----LDNQR 1440

Query: 614  AAQEQLNKIRDSYAKLLGHQ-NLKQKIKHVVKLKDENSQLKSEVSKLRCQ---LAKKKQS 669
                 L K +  + +LL  + N+        K  DE  + ++E  +   +   LA+  + 
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISS------KYADERDRAEAEAREKETKALSLARALEE 1494

Query: 670  ETKLQEEL---NKVLGIK-------HFDPSKAFHHESKENFALKTPLKEGNTNCYRAPME 719
              + +EEL   NK+L  +         D  K  H   K   AL+T ++E  T       E
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554

Query: 720  CQ 721
             Q
Sbjct: 1555 LQ 1556



 Score =  110 bits (275), Expect = 5e-24
 Identities = 137/658 (20%), Positives = 292/658 (44%), Gaps = 50/658 (7%)

Query: 40   KSQRFKQQKESKQNLNVDKDTTLPASARKVKS------SESKKESQKNDKDLKILEKEIR 93
            K ++  +++ S    N+ ++     +  K+K+      SE +   +K +K  + LEK  R
Sbjct: 999  KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1058

Query: 94   VLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKS 153
             L  +      +I DL+ ++ +++ +L    +++  L A  A L+    E+ + N  LK 
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQL---AKKEEELQAALARLDD---EIAQKNNALKK 1112

Query: 154  KFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQL 213
                 G+  +L+         RNK E + R +  + E ++ +L+ T  S    Q   A+ 
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1172

Query: 214  EGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLK 273
            E + V++ K+ +DE++ + +             QV++ +   AQ  E L E+ ++    K
Sbjct: 1173 EQE-VTVLKKALDEETRSHEA------------QVQEMRQKHAQAVEELTEQLEQFKRAK 1219

Query: 274  QSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQER 333
             +L++N   L K+  DL  + ++L + K++  ++ ++    L A++Q L+ K    ++ R
Sbjct: 1220 ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK----LEAQVQELQSKCSDGERAR 1275

Query: 334  -------EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDEL 386
                    KLQ +   +  +L + +  +  L + + S   ++   + L +EE +Q L+  
Sbjct: 1276 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1335

Query: 387  DKLQQKEEQAERLVKQLEE--EAKSRAEE----LKLLEEKLKGKEAELEKSSAAHTQATL 440
             KL+Q EE+   L  QL+E  EAK   E     L +     K K  +   +  A  +   
Sbjct: 1336 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1395

Query: 441  LLQEKYDSMVQSLEDVTAQF---ESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQH 497
              Q++ +++ Q  E+  A +   E  K     E++DL ++  + ++  +   K       
Sbjct: 1396 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455

Query: 498  QILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLE 557
             +   ++ + +Y       + ++  KET+   +  + L++  + + +L++  +  + ++E
Sbjct: 1456 LLAEEKNISSKYADERDRAEAEAREKETKALSLARA-LEEALEAKEELERTNKMLKAEME 1514

Query: 558  DEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE 617
            D    K +      EL +         EE+  + +  + +L A E  K  L     A + 
Sbjct: 1515 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1574

Query: 618  QLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 675
            Q    RD  A+    QN +++ +   +L +  ++L+ E  +     A KK+ E  L++
Sbjct: 1575 QFE--RDLQAR--DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628



 Score =  105 bits (263), Expect = 1e-22
 Identities = 139/662 (20%), Positives = 294/662 (44%), Gaps = 94/662 (14%)

Query: 47   QKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKI-----LEKEIRVLLQERGA 101
            Q+E++Q LNV         + K++  E ++ S ++  D ++     LE+ I  L  +   
Sbjct: 1325 QEETRQKLNV---------STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375

Query: 102  QDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSEN--- 158
              +++QD  + +E +E       +E  +L+           +L +T   L+ +  +    
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435

Query: 159  -GNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKL 217
              NQ+ L + +LE      K++ K   ++A+++ +  K    +R   E++ +  + E K 
Sbjct: 1436 LDNQRQL-VSNLE------KKQRKFDQLLAEEKNISSKY-ADERDRAEAEAR--EKETKA 1485

Query: 218  VSIEK---EKIDEKSETEK----LLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEIL 270
            +S+ +   E ++ K E E+    L   +E++  + D V K   ++ + +  L+ + +E+ 
Sbjct: 1486 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1545

Query: 271  SLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQ 330
            +  + LE+ +         L V  Q L+ + E  +    E NE    ++Q    ++  E 
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1605

Query: 331  QEREKLQ------QKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLD 384
            ++  K +      +K+L+ D L   E +  S++  +     EE +K+    + ++K    
Sbjct: 1606 EDERKQRALAAAAKKKLEGD-LKDLELQADSAIKGR-----EEAIKQLRKLQAQMKDFQR 1659

Query: 385  ELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKG-----KEAELEKSSAAHTQAT 439
            EL+  +   ++     K+ E++AKS   +L  L+E L       K+A+LEK   A   A+
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS 1719

Query: 440  LLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI 499
             L      S   +L+D   + E+  A    E+E+ +    ++ ++  KA + AE + ++ 
Sbjct: 1720 SL------SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE- 1772

Query: 500  LATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDE 559
            LATE S                              QK    + QL++Q ++ R +L + 
Sbjct: 1773 LATERST----------------------------AQKNESARQQLERQNKELRSKLHEM 1804

Query: 560  EGR-KAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQ 618
            EG  K++ ++T A L  +I +   L E++  + +  Q    + + +K   L E     E 
Sbjct: 1805 EGAVKSKFKSTIAALEAKIAQ---LEEQVEQEAREKQAATKSLK-QKDKKLKEILLQVED 1860

Query: 619  LNKIRDSYAKLL--GHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEE 676
              K+ + Y +    G+  +KQ  + + + ++E+ ++ +   KL+ +L +  +S   +  E
Sbjct: 1861 ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1920

Query: 677  LN 678
            +N
Sbjct: 1921 VN 1922



 Score = 86.3 bits (212), Expect = 9e-17
 Identities = 119/536 (22%), Positives = 249/536 (46%), Gaps = 54/536 (10%)

Query: 172  MKLRN----KRETKMRGMMA---KQEGMEMK---LQVTQRSLEESQGKIAQLEGKLVSIE 221
            +KLRN    +  TK++ ++    ++E M+ K   LQ T+   ++++ ++ +LE K   + 
Sbjct: 827  LKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT 886

Query: 222  KEK--IDE--KSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKND---EILSLKQ 274
            +EK  + E  ++ETE   E  E     + + ++ +  + ++E  L+E+ D   ++ + ++
Sbjct: 887  EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK 946

Query: 275  SLEENIVILSKQVEDLNVKCQLLEKEK-EDHVNRNREHNENLNAEMQNLKQKFILEQQER 333
             + + ++ L +Q+E+     Q L+ EK        +  +E L  + QN K       +ER
Sbjct: 947  KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL-----SKER 1001

Query: 334  EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQK- 392
            + L+++   + + L +E+E + +L  KL +  E M+ E  +  ++ +++  EL+KL++K 
Sbjct: 1002 KLLEERISDLTTNLAEEEEKAKNL-TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1060

Query: 393  EEQAERLVKQLEEEAKSRAE---ELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSM 449
            E  A    +Q+ +     AE   +L   EE+L+   A L+   A    A   ++E    +
Sbjct: 1061 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1120

Query: 450  VQSLEDVTAQ------FESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATE 503
                ED+ ++       E  K     E+E LK E     +  A         Q ++ A  
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA--------TQQELRAKR 1172

Query: 504  SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRK 563
                  ++  LD +T+S   E +++E+     Q + +L  QL+Q    F++   + +  K
Sbjct: 1173 EQEVTVLKKALDEETRS--HEAQVQEMRQKHAQAVEELTEQLEQ----FKRAKANLDKNK 1226

Query: 564  AEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQ--EQLNK 621
               E   A+L  E+       +E+ +K K  + Q+   E++ +    E   A+  ++++K
Sbjct: 1227 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ--ELQSKCSDGERARAELNDKVHK 1284

Query: 622  IRDSYAKLLGHQNLKQ--KIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 675
            +++    + G  N  +   IK    +   +SQL+     L+ +  +K    TKL++
Sbjct: 1285 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340



 Score = 83.2 bits (204), Expect = 8e-16
 Identities = 105/509 (20%), Positives = 216/509 (42%), Gaps = 75/509 (14%)

Query: 41   SQRFKQQKESKQNLNVDKDTTLPASARKVKSS-ESKKESQKNDKDLKI-----------L 88
            S ++  +++  +    +K+T   + AR ++ + E+K+E ++ +K LK            +
Sbjct: 1464 SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1523

Query: 89   EKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN 148
             K +  L + + A + ++++++T+LE++E  L A    K  L  N   L+ Q        
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF------E 1577

Query: 149  ELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMA----KQEG----MEMKLQVTQ 200
              L+++  +N  ++      L   +   + E K R + A    K EG    +E++     
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637

Query: 201  RSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEE 260
            +  EE+  ++ +L+ ++   ++E  D ++  +++    +E    +  +E    D+ QL+E
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA---DLMQLQE 1694

Query: 261  NL-------KEKNDEILSLKQSLEENIV---ILSKQVEDLNVKCQLLEKEKEDHVNRNRE 310
            +L       K+ + E   L + L  ++     L  +   L  +   LE+E E+       
Sbjct: 1695 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1754

Query: 311  HNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVK 370
             ++ +    Q  +Q       ER   Q+ E     L +Q KEL S LH+      E  VK
Sbjct: 1755 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE-----MEGAVK 1809

Query: 371  EKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEK 430
             K       K T+  L          E  + QLEE+ +  A E +   + LK K+ +L++
Sbjct: 1810 SK------FKSTIAAL----------EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1853

Query: 431  SSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGK 490
                     +LLQ      V+    +  Q++       + ++ LK +    +E++ +   
Sbjct: 1854 ---------ILLQ------VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898

Query: 491  NAEDVQHQILATESSNQEYVRMLLDLQTK 519
            N   +Q ++     SN+   R +  L++K
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNALKSK 1927



 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 82/336 (24%), Positives = 154/336 (45%), Gaps = 32/336 (9%)

Query: 376  EEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAH 435
            EEE++   DEL K ++++++AE  +K+LE++     EE  LL+E+L   +AE E  + A 
Sbjct: 851  EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL---QAETELYAEAE 907

Query: 436  TQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDV 495
                 L  +K     Q LE++  + E       + +E+ +     LQ +  K  +   D+
Sbjct: 908  EMRVRLAAKK-----QELEEILHEME-------ARLEEEEDRGQQLQAERKKMAQQMLDL 955

Query: 496  QHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQ 555
            + Q+   E++ Q+       LQ +    E +IK++    L  + D  N+L ++ +   ++
Sbjct: 956  EEQLEEEEAARQK-------LQLEKVTAEAKIKKLEDEIL-VMDDQNNKLSKERKLLEER 1007

Query: 556  LEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAA 615
            + D     AE+E     LT+  NK   +  EL  + K  +      E  K+ L  +    
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067

Query: 616  QEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSE---TK 672
             EQ+  ++   A+L       Q  K   +L+   ++L  E+++    L K ++ E   + 
Sbjct: 1068 HEQIADLQAQIAEL-----KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1122

Query: 673  LQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKE 708
            LQE+L+     ++    K      +E  ALKT L++
Sbjct: 1123 LQEDLDSERAARN-KAEKQKRDLGEELEALKTELED 1157



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 93/420 (22%), Positives = 192/420 (45%), Gaps = 50/420 (11%)

Query: 301  KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 360
            KED + + +E  +    E++ L+QK   +  E + L Q++LQ ++ L  E E    +  +
Sbjct: 857  KEDELQKTKERQQKAENELKELEQKHS-QLTEEKNLLQEQLQAETELYAEAE---EMRVR 912

Query: 361  LCSFQEEMVKEKNLFEEELKQTLDELDKLQ-QKEEQAERLV---KQLEEEAKSRAEELKL 416
            L + ++E+ +  +  E  L++  D   +LQ ++++ A++++   +QLEEE  +R ++L+L
Sbjct: 913  LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR-QKLQL 971

Query: 417  LEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQF--ESYKALTASEIEDL 474
             +   + K  +LE            L ++   + + + D+T     E  KA   +++++ 
Sbjct: 972  EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN- 1030

Query: 475  KLEN--SSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQT-------KSALKET 525
            K E+  S L+ +  K  K+ ++++      E    ++   + DLQ        + A KE 
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1090

Query: 526  EIKEITVSFLQKITDLQNQLKQQEE------DFRKQLEDEEGRKAEKENTTAELTEEINK 579
            E++        +I    N LK+  E      D ++ L+ E   + + E    +L EE+  
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150

Query: 580  WRLLYEELYNKTKPFQLQLDA-----FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQN 634
             +   E+  + T   Q +L A       V K+AL  E  + + Q+ ++R  +A+ +  + 
Sbjct: 1151 LKTELEDTLDSTAT-QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV--EE 1207

Query: 635  LKQKIKHVVKLKDENSQLKSEVSKLRCQLA---------------KKKQSETKLQEELNK 679
            L ++++   + K    + K  + K    LA               KKK+ E ++QE  +K
Sbjct: 1208 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1267


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.306    0.124    0.315 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,266,007
Number of Sequences: 37866
Number of extensions: 1167960
Number of successful extensions: 29776
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 697
Number of HSP's successfully gapped in prelim test: 1409
Number of HSP's that attempted gapping in prelim test: 7207
Number of HSP's gapped (non-prelim): 8367
length of query: 725
length of database: 18,247,518
effective HSP length: 110
effective length of query: 615
effective length of database: 14,082,258
effective search space: 8660588670
effective search space used: 8660588670
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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