Guide to the Human Genome
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Search of human proteins with 21265113

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21265113 transmembrane 4 superfamily member 5 [Homo sapiens]
         (197 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21265113 transmembrane 4 superfamily member 5 [Homo sapiens]       422   e-119
gi|21265101 transmembrane 4 superfamily member 1 [Homo sapiens]       195   2e-50
gi|4759240 transmembrane 4 superfamily member 4 [Homo sapiens]        169   1e-42
gi|20270327 transmembrane 4 L six family member 18 [Homo sapiens]     129   2e-30
gi|115511028 transmembrane 4 L six family member 19 [Homo sapiens]    109   2e-24
gi|188528611 transmembrane 4 L six family member 20 [Homo sapiens]     59   2e-09
gi|13994372 keratin associated protein 17-1 [Homo sapiens]             33   0.16 
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s...    32   0.27 
gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo s...    32   0.27 
gi|6912666 sialin [Homo sapiens]                                       31   0.60 
gi|9790235 solute carrier family 7, member 10 [Homo sapiens]           31   0.60 
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]            31   0.78 
gi|54400749 keratin associated protein 5-1 [Homo sapiens]              29   3.0  
gi|109255251 loricrin [Homo sapiens]                                   28   3.9  
gi|67003568 skin-specific protein 32 [Homo sapiens]                    28   5.0  
gi|8394398 taste receptor T2R3 [Homo sapiens]                          28   5.0  
gi|21314671 transient receptor potential cation channel, subfami...    27   8.6  
gi|148613866 tudor domain containing 10 isoform a [Homo sapiens]       27   8.6  
gi|157738623 olfactory receptor, family 51, subfamily B, member ...    27   8.6  
gi|148613864 tudor domain containing 10 isoform b [Homo sapiens]       27   8.6  

>gi|21265113 transmembrane 4 superfamily member 5 [Homo sapiens]
          Length = 197

 Score =  422 bits (1085), Expect = e-119
 Identities = 197/197 (100%), Positives = 197/197 (100%)

Query: 1   MCTGKCARCVGLSLITLCLVCIVANALLLVPNGETSWTNTNHLSLQVWLMGGFIGGGLMV 60
           MCTGKCARCVGLSLITLCLVCIVANALLLVPNGETSWTNTNHLSLQVWLMGGFIGGGLMV
Sbjct: 1   MCTGKCARCVGLSLITLCLVCIVANALLLVPNGETSWTNTNHLSLQVWLMGGFIGGGLMV 60

Query: 61  LCPGIAAVRAGGKGCCGAGCCGNRCRMLRSVFSSAFGVLGAIYCLSVSGAGLRNGPRCLM 120
           LCPGIAAVRAGGKGCCGAGCCGNRCRMLRSVFSSAFGVLGAIYCLSVSGAGLRNGPRCLM
Sbjct: 61  LCPGIAAVRAGGKGCCGAGCCGNRCRMLRSVFSSAFGVLGAIYCLSVSGAGLRNGPRCLM 120

Query: 121 NGEWGYHFEDTAGAYLLNRTLWDRCEAPPRVVPWNVTLFSLLVAASCLEIVLCGIQLVNA 180
           NGEWGYHFEDTAGAYLLNRTLWDRCEAPPRVVPWNVTLFSLLVAASCLEIVLCGIQLVNA
Sbjct: 121 NGEWGYHFEDTAGAYLLNRTLWDRCEAPPRVVPWNVTLFSLLVAASCLEIVLCGIQLVNA 180

Query: 181 TIGVFCGDCRKKQDTPH 197
           TIGVFCGDCRKKQDTPH
Sbjct: 181 TIGVFCGDCRKKQDTPH 197


>gi|21265101 transmembrane 4 superfamily member 1 [Homo sapiens]
          Length = 202

 Score =  195 bits (496), Expect = 2e-50
 Identities = 93/197 (47%), Positives = 121/197 (61%), Gaps = 4/197 (2%)

Query: 1   MCTGKCARCVGLSLITLCLVCIVANALLLVPNGETSWTNTNHLSLQVWLMGGFIGGGLMV 60
           MC GKCARC+G SL+ L L+CI AN LL  PNGET + + NHLS  VW   G +GGGL++
Sbjct: 1   MCYGKCARCIGHSLVGLALLCIAANILLYFPNGETKYASENHLSRFVWFFSGIVGGGLLM 60

Query: 61  LCPG---IAAVRAGGKGCCGAGCCGNRCRMLRSVFSSAFGVLGAIYCLSVSGAGLRNGPR 117
           L P    I   +    GCCG   CG RC ML SV ++  G+ G+ YC+ V+  GL  GP 
Sbjct: 61  LLPAFVFIGLEQDDCCGCCGHENCGKRCAMLSSVLAALIGIAGSGYCVIVAALGLAEGPL 120

Query: 118 CLMN-GEWGYHFEDTAGAYLLNRTLWDRCEAPPRVVPWNVTLFSLLVAASCLEIVLCGIQ 176
           CL + G+W Y F  T G YLL+ + W  C  P  +V WNV+LFS+L+A   +E +LC IQ
Sbjct: 121 CLDSLGQWNYTFASTEGQYLLDTSTWSECTEPKHIVEWNVSLFSILLALGGIEFILCLIQ 180

Query: 177 LVNATIGVFCGDCRKKQ 193
           ++N  +G  CG C   Q
Sbjct: 181 VINGVLGGICGFCCSHQ 197


>gi|4759240 transmembrane 4 superfamily member 4 [Homo sapiens]
          Length = 202

 Score =  169 bits (428), Expect = 1e-42
 Identities = 84/196 (42%), Positives = 114/196 (58%), Gaps = 11/196 (5%)

Query: 1   MCTGKCARCVGLSLITLCLVCIVANALLLVPNGETSWTNTNHLSLQVWLMGGFIGGGLMV 60
           MCTG CARC+G +LI L     +AN LL  P G+    N +HLS ++W  GG +G G+++
Sbjct: 1   MCTGGCARCLGGTLIPLAFFGFLANILLFFPGGKVIDDN-DHLSQEIWFFGGILGSGVLM 59

Query: 61  LCPGIAAVRAGGKGCCGAGCCGN-----RCRMLRSVFSSAFGVLGAIYCLSVSGAGLRNG 115
           + P +  +      CCG  CCGN     R  M  S   +  G LGA Y   +S   +  G
Sbjct: 60  IFPALVFLGLKNNDCCG--CCGNEGCGKRFAMFTSTIFAVVGFLGAGYSFIISAISINKG 117

Query: 116 PRCLM-NGEWGYHFEDTAGAYLLNRTLWDRCEAPPRVVPWNVTLFSLLVAASCLEIVLCG 174
           P+CLM N  WGY F D  G YL +  LW++C  P  VVPWN+TLFS+L+    +++VLC 
Sbjct: 118 PKCLMANSTWGYPFHD--GDYLNDEALWNKCREPLNVVPWNLTLFSILLVVGGIQMVLCA 175

Query: 175 IQLVNATIGVFCGDCR 190
           IQ+VN  +G  CGDC+
Sbjct: 176 IQVVNGLLGTLCGDCQ 191


>gi|20270327 transmembrane 4 L six family member 18 [Homo sapiens]
          Length = 201

 Score =  129 bits (323), Expect = 2e-30
 Identities = 67/190 (35%), Positives = 100/190 (52%), Gaps = 3/190 (1%)

Query: 1   MCTGKCARCVGLSLITLCLVCIVANALLLVPNGETSWTNTNHLSLQVWLMGGFIGGGLMV 60
           M + KC  C+   LI L L  I+ N LL  PNG+TS+ ++N L+  VW   G    G+M+
Sbjct: 1   MGSRKCGGCLSCLLIPLALWSIIVNILLYFPNGQTSYASSNKLTNYVWYFEGICFSGIMM 60

Query: 61  LCPGIAAVRAGGKG---CCGAGCCGNRCRMLRSVFSSAFGVLGAIYCLSVSGAGLRNGPR 117
           L      +         CC +  C  +   L S+  S+ G+  + YCL +S  GL  GP 
Sbjct: 61  LIVTTVLLVLENNNNYKCCQSENCSKKYVTLLSIIFSSLGIAFSGYCLVISALGLVQGPY 120

Query: 118 CLMNGEWGYHFEDTAGAYLLNRTLWDRCEAPPRVVPWNVTLFSLLVAASCLEIVLCGIQL 177
           C     W Y FE TAG +L + ++W +C  P  VV WN+ LFS+L+  S L++++C I++
Sbjct: 121 CRTLDGWEYAFEGTAGRFLTDSSIWIQCLEPAHVVEWNIILFSILITLSGLQVIICLIRV 180

Query: 178 VNATIGVFCG 187
           V     + CG
Sbjct: 181 VMQLSKILCG 190


>gi|115511028 transmembrane 4 L six family member 19 [Homo sapiens]
          Length = 209

 Score =  109 bits (272), Expect = 2e-24
 Identities = 69/199 (34%), Positives = 105/199 (52%), Gaps = 16/199 (8%)

Query: 6   CARCVGLSLITLCLVCIVANALLLVPNGETSWTNTNHLSLQVWLMGGFIGGGLMVLCPGI 65
           C+R +GLSL T  L    AN  LL+PN + ++     L     L  G  GGGLMVL   I
Sbjct: 14  CSRILGLSLGTAALFAAGANVALLLPNWDVTYLLRGLLGRHAMLGTGLWGGGLMVLTAAI 73

Query: 66  AAVRAGGK-GCCG-AGCCGNRCRMLRSVFSSAFGVLGAIYCLSVSGAGLRNGPRCLMN-- 121
                G + GC   +G C +   +L ++ S    +LGA+ C   SG  L++GP C+ +  
Sbjct: 74  LISLMGWRYGCFSKSGLCRS---VLTALLSGGLALLGALICFVTSGVALKDGPFCMFDVS 130

Query: 122 -------GEWGYHFEDTAGA-YLLNRTLWDR-CEAPPRVVPWNVTLFSLLVAASCLEIVL 172
                   ++GY F+D     YL +R+LW+  C  P   V W+V+LFS L+  S L+++L
Sbjct: 131 SFNQTQAWKYGYPFKDLHSRNYLYDRSLWNSVCLEPSAAVVWHVSLFSALLCISLLQLLL 190

Query: 173 CGIQLVNATIGVFCGDCRK 191
             + ++N+ +G+FC  C K
Sbjct: 191 VVVHVINSLLGLFCSLCEK 209


>gi|188528611 transmembrane 4 L six family member 20 [Homo sapiens]
          Length = 229

 Score = 59.3 bits (142), Expect = 2e-09
 Identities = 39/116 (33%), Positives = 54/116 (46%), Gaps = 6/116 (5%)

Query: 2   CTGKCARCVGLSLITLCLVCIVANAL-LLVPNGETSWTNTNHLSLQVWLMGGFIGGGLMV 60
           C      C G SL+ L L+ +V NA+ L+V   E    + N +S   W   G IG GLM 
Sbjct: 3   CCEGWTSCNGFSLLVLLLLGVVLNAIPLIVSLVEEDQFSQNPISCFEWWFPGIIGAGLMA 62

Query: 61  LCPGIAAVRAGGKGCCGAGCCGNRCRMLRSVFSSAFGVLGAIYCLSVSGAGLRNGP 116
           +     ++ A  + CC      NR  M  S   S   V+GA+YC+ +S   L  GP
Sbjct: 63  IPATTMSLTARKRACCN-----NRTGMFLSSLFSVITVIGALYCMLISIQALLKGP 113


>gi|13994372 keratin associated protein 17-1 [Homo sapiens]
          Length = 105

 Score = 33.1 bits (74), Expect = 0.16
 Identities = 11/24 (45%), Positives = 13/24 (54%)

Query: 62 CPGIAAVRAGGKGCCGAGCCGNRC 85
          C G       G GCCG+ CCG+ C
Sbjct: 62 CGGCGGCGGCGGGCCGSSCCGSSC 85



 Score = 32.0 bits (71), Expect = 0.35
 Identities = 21/62 (33%), Positives = 25/62 (40%), Gaps = 6/62 (9%)

Query: 62  CPGIAAVRAGGKGC----CGAGCCGNRCRMLRSVFSSAFGVLGAIYC-LSVSGAGLRNGP 116
           C G      GG GC    CG+ CCG+ C           G  G+  C  S  G+G   GP
Sbjct: 35  CCGCGGSGCGGSGCGGSCCGSSCCGSGCGGCGGCGGCGGGCCGSSCCGSSCCGSGC-CGP 93

Query: 117 RC 118
            C
Sbjct: 94  VC 95



 Score = 30.0 bits (66), Expect = 1.3
 Identities = 15/34 (44%), Positives = 17/34 (50%), Gaps = 7/34 (20%)

Query: 52 GFIGGGLMVLCPGIAAVRAGGKGCCGAGCCGNRC 85
          G  GGG    C G +     G  CCG+GCCG  C
Sbjct: 69 GGCGGG----CCGSSCC---GSSCCGSGCCGPVC 95


>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
           sapiens]
          Length = 1074

 Score = 32.3 bits (72), Expect = 0.27
 Identities = 29/110 (26%), Positives = 41/110 (37%), Gaps = 24/110 (21%)

Query: 61  LCPGIAAVRAGGKGCCGAGCCG---NRCRMLRSVFSSAFGVLGAIYCLSVSGAGLR---- 113
           L PG   +   G+   G G CG   + CR++    +   G LG    L +    LR    
Sbjct: 457 LSPGCDGILGSGRRPDGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIA 516

Query: 114 -------------NGPRCLMNGEWGYHFEDTAGAYLLNRTLWDRCEAPPR 150
                         G R ++NG W     D  G+Y    T++ R   PPR
Sbjct: 517 QLRPSSNYLALRGPGGRSIINGNWAV---DPPGSYRAGGTVF-RYNRPPR 562


>gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo
           sapiens]
          Length = 877

 Score = 32.3 bits (72), Expect = 0.27
 Identities = 29/110 (26%), Positives = 41/110 (37%), Gaps = 24/110 (21%)

Query: 61  LCPGIAAVRAGGKGCCGAGCCG---NRCRMLRSVFSSAFGVLGAIYCLSVSGAGLR---- 113
           L PG   +   G+   G G CG   + CR++    +   G LG    L +    LR    
Sbjct: 457 LSPGCDGILGSGRRPDGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIA 516

Query: 114 -------------NGPRCLMNGEWGYHFEDTAGAYLLNRTLWDRCEAPPR 150
                         G R ++NG W     D  G+Y    T++ R   PPR
Sbjct: 517 QLRPSSNYLALRGPGGRSIINGNWAV---DPPGSYRAGGTVF-RYNRPPR 562


>gi|6912666 sialin [Homo sapiens]
          Length = 495

 Score = 31.2 bits (69), Expect = 0.60
 Identities = 20/67 (29%), Positives = 30/67 (44%), Gaps = 1/67 (1%)

Query: 46  QVWLMGGFIGGGLMVLCPG-IAAVRAGGKGCCGAGCCGNRCRMLRSVFSSAFGVLGAIYC 104
           Q W++G F  G ++   PG   A + GGK   G G  G     L +  ++  GV   I  
Sbjct: 108 QGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVL 167

Query: 105 LSVSGAG 111
            ++ G G
Sbjct: 168 RALEGLG 174


>gi|9790235 solute carrier family 7, member 10 [Homo sapiens]
          Length = 523

 Score = 31.2 bits (69), Expect = 0.60
 Identities = 18/63 (28%), Positives = 33/63 (52%), Gaps = 2/63 (3%)

Query: 12  LSLITLCLVCIVANALLLVPNGETSWTNTNHLSLQVWLMGGFIG--GGLMVLCPGIAAVR 69
           LS  T+ +  I+ + + + P G    + +  L+L VW++GG +   G L     G+A  +
Sbjct: 43  LSACTIIIGNIIGSGIFISPKGVLEHSGSVGLALFVWVLGGGVTALGSLCYAELGVAIPK 102

Query: 70  AGG 72
           +GG
Sbjct: 103 SGG 105


>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
          Length = 846

 Score = 30.8 bits (68), Expect = 0.78
 Identities = 14/39 (35%), Positives = 18/39 (46%)

Query: 112 LRNGPRCLMNGEWGYHFEDTAGAYLLNRTLWDRCEAPPR 150
           L   P   +NGEW  H + +   Y  NR   +R   PPR
Sbjct: 259 LPGSPAIQINGEWETHKDSSGRCYYYNRGTQERTWKPPR 297


>gi|54400749 keratin associated protein 5-1 [Homo sapiens]
          Length = 278

 Score = 28.9 bits (63), Expect = 3.0
 Identities = 17/38 (44%), Positives = 19/38 (50%), Gaps = 3/38 (7%)

Query: 51  GGFIGG-GLMVLCPGIAAVRAGGKGCCGAGC--CGNRC 85
           GG  GG G    C G      G KG CG+GC  CG+ C
Sbjct: 171 GGSKGGCGSCGGCKGGCGSCGGSKGGCGSGCGGCGSGC 208


>gi|109255251 loricrin [Homo sapiens]
          Length = 312

 Score = 28.5 bits (62), Expect = 3.9
 Identities = 28/84 (33%), Positives = 32/84 (38%), Gaps = 14/84 (16%)

Query: 51  GGFIGG-----GLMVLCPGIAAVRAGGKGCCGAGCCGNRCRMLRSVFSSAFGVL--GAIY 103
           GG IGG     G  V   G      GG GC  +G  G+ C      FSS  G    G   
Sbjct: 74  GGGIGGCGGGSGGSVKYSGGGGSSGGGSGCFSSGGGGSGC------FSSGGGGSSGGGSG 127

Query: 104 CLSVSGAGLR-NGPRCLMNGEWGY 126
           C S  G G    G  C  +G  G+
Sbjct: 128 CFSSGGGGSSGGGSGCFSSGGGGF 151


>gi|67003568 skin-specific protein 32 [Homo sapiens]
          Length = 250

 Score = 28.1 bits (61), Expect = 5.0
 Identities = 9/16 (56%), Positives = 11/16 (68%)

Query: 70  AGGKGCCGAGCCGNRC 85
           +G  GCCG+G CG  C
Sbjct: 204 SGSSGCCGSGGCGCSC 219


>gi|8394398 taste receptor T2R3 [Homo sapiens]
          Length = 316

 Score = 28.1 bits (61), Expect = 5.0
 Identities = 18/51 (35%), Positives = 26/51 (50%), Gaps = 15/51 (29%)

Query: 12 LSLITLCLVCIVANALLLV---PNG----------ETSWTNTNHLSLQVWL 49
          L+L+ + L+CI+     L+   PN           + SWT TNHLS  +WL
Sbjct: 51 LALLRIILLCIILTDSFLIEFSPNTHDSGIIMQIIDVSWTFTNHLS--IWL 99


>gi|21314671 transient receptor potential cation channel, subfamily
           M, member 4 [Homo sapiens]
          Length = 1214

 Score = 27.3 bits (59), Expect = 8.6
 Identities = 9/17 (52%), Positives = 11/17 (64%)

Query: 69  RAGGKGCCGAGCCGNRC 85
           ++G  GCCG  C G RC
Sbjct: 752 QSGRPGCCGGRCGGRRC 768


>gi|148613866 tudor domain containing 10 isoform a [Homo sapiens]
          Length = 366

 Score = 27.3 bits (59), Expect = 8.6
 Identities = 17/53 (32%), Positives = 22/53 (41%), Gaps = 11/53 (20%)

Query: 107 VSGAGLRNGPRCLMNGEWGYHFEDTAGAYLLNRTLWDRCEAPPRVVPWNVTLF 159
           + G+ +  G RCL      YH  D   A       W+RC    RV  W V +F
Sbjct: 240 LEGSTVMRGTRCLAE----YHLGDYGHA-------WNRCWVLDRVDTWAVVMF 281


>gi|157738623 olfactory receptor, family 51, subfamily B, member 2
           [Homo sapiens]
          Length = 312

 Score = 27.3 bits (59), Expect = 8.6
 Identities = 14/37 (37%), Positives = 20/37 (54%)

Query: 156 VTLFSLLVAASCLEIVLCGIQLVNATIGVFCGDCRKK 192
           V L SL +   CL I+   I ++N  IG+  G+ R K
Sbjct: 198 VILISLTIFLDCLIILFSYILILNTVIGIASGEERAK 234


>gi|148613864 tudor domain containing 10 isoform b [Homo sapiens]
          Length = 351

 Score = 27.3 bits (59), Expect = 8.6
 Identities = 17/53 (32%), Positives = 22/53 (41%), Gaps = 11/53 (20%)

Query: 107 VSGAGLRNGPRCLMNGEWGYHFEDTAGAYLLNRTLWDRCEAPPRVVPWNVTLF 159
           + G+ +  G RCL      YH  D   A       W+RC    RV  W V +F
Sbjct: 240 LEGSTVMRGTRCLAE----YHLGDYGHA-------WNRCWVLDRVDTWAVVMF 281


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.328    0.143    0.496 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,651,044
Number of Sequences: 37866
Number of extensions: 391621
Number of successful extensions: 1430
Number of sequences better than 10.0: 20
Number of HSP's better than 10.0 without gapping: 12
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 1375
Number of HSP's gapped (non-prelim): 40
length of query: 197
length of database: 18,247,518
effective HSP length: 97
effective length of query: 100
effective length of database: 14,574,516
effective search space: 1457451600
effective search space used: 1457451600
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 59 (27.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
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