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Search of human proteins with 212549538
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|212549538 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12
[Homo sapiens]
(906 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|212549538 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12 [Ho... 1791 0.0
gi|100913202 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 iso... 1748 0.0
gi|100913204 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 iso... 1621 0.0
gi|132566527 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 iso... 1586 0.0
gi|239755744 PREDICTED: similar to Putative ATP-dependent RNA he... 435 e-122
gi|239755742 PREDICTED: similar to DEAD/H (Asp-Glu-Ala-Asp/His) ... 319 6e-87
gi|14042978 BRCA1 interacting protein C-terminal helicase 1 [Hom... 271 3e-72
gi|91984775 regulator of telomere elongation helicase 1 isoform ... 230 5e-60
gi|7706541 regulator of telomere elongation helicase 1 isoform 1... 230 5e-60
gi|15834617 excision repair cross-complementing rodent repair de... 124 3e-28
gi|195947407 excision repair cross-complementing rodent repair d... 66 1e-10
gi|239743668 PREDICTED: hypothetical protein XP_002342944 [Homo ... 62 2e-09
gi|239745348 PREDICTED: hypothetical protein XP_002343431 [Homo ... 62 3e-09
gi|239740967 PREDICTED: hypothetical protein XP_002342051 [Homo ... 62 3e-09
gi|148746195 trichohyalin [Homo sapiens] 51 6e-06
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 50 1e-05
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 50 1e-05
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 50 1e-05
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 50 1e-05
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 50 1e-05
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 50 1e-05
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 50 1e-05
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 50 1e-05
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 48 5e-05
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 48 5e-05
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 48 5e-05
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 48 5e-05
gi|119120918 coiled-coil domain containing 64 [Homo sapiens] 48 5e-05
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 47 6e-05
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 47 6e-05
>gi|212549538 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12 [Homo
sapiens]
Length = 906
Score = 1791 bits (4640), Expect = 0.0
Identities = 906/906 (100%), Positives = 906/906 (100%)
Query: 1 MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS 60
MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS
Sbjct: 1 MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS 60
Query: 61 WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK 120
WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK
Sbjct: 61 WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK 120
Query: 121 KEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
KEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET
Sbjct: 121 KEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
Query: 181 GPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQLA 240
GPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQLA
Sbjct: 181 GPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQLA 240
Query: 241 QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKGAE 300
QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKGAE
Sbjct: 241 QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKGAE 300
Query: 301 EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP 360
EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP
Sbjct: 301 EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP 360
Query: 361 AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTTTSMHSVEVSGSQLCQAHS 420
AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTTTSMHSVEVSGSQLCQAHS
Sbjct: 361 AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTTTSMHSVEVSGSQLCQAHS 420
Query: 421 QLLQYMERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGMELKTIND 480
QLLQYMERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGMELKTIND
Sbjct: 421 QLLQYMERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGMELKTIND 480
Query: 481 FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR 540
FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR
Sbjct: 481 FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR 540
Query: 541 TTEALAAPADESQASVPQPASPLMHIEGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL 600
TTEALAAPADESQASVPQPASPLMHIEGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL
Sbjct: 541 TTEALAAPADESQASVPQPASPLMHIEGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL 600
Query: 601 NPAVHFAQVVKECRAVVIAGGTMQPVSNFRQQLLACAGVEAERVVEFSCGHVIPPDNILP 660
NPAVHFAQVVKECRAVVIAGGTMQPVSNFRQQLLACAGVEAERVVEFSCGHVIPPDNILP
Sbjct: 601 NPAVHFAQVVKECRAVVIAGGTMQPVSNFRQQLLACAGVEAERVVEFSCGHVIPPDNILP 660
Query: 661 LVICSGVSNQPLEFTFQKRDLPQMMDEVGRILCNLCGVVSGGVVCFFPSYEYLRQVHAHW 720
LVICSGVSNQPLEFTFQKRDLPQMMDEVGRILCNLCGVVSGGVVCFFPSYEYLRQVHAHW
Sbjct: 661 LVICSGVSNQPLEFTFQKRDLPQMMDEVGRILCNLCGVVSGGVVCFFPSYEYLRQVHAHW 720
Query: 721 EKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSRCLQACGQERGPVTGALLLSVVGGKMS 780
EKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSRCLQACGQERGPVTGALLLSVVGGKMS
Sbjct: 721 EKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSRCLQACGQERGPVTGALLLSVVGGKMS 780
Query: 781 EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAHPGKALVENLCMKA 840
EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAHPGKALVENLCMKA
Sbjct: 781 EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAHPGKALVENLCMKA 840
Query: 841 VNQSIGRAIRHQKDFASIVLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR 900
VNQSIGRAIRHQKDFASIVLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR
Sbjct: 841 VNQSIGRAIRHQKDFASIVLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR 900
Query: 901 EKSASS 906
EKSASS
Sbjct: 901 EKSASS 906
>gi|100913202 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
isoform 1 [Homo sapiens]
Length = 906
Score = 1748 bits (4526), Expect = 0.0
Identities = 884/906 (97%), Positives = 896/906 (98%)
Query: 1 MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS 60
MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS
Sbjct: 1 MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS 60
Query: 61 WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK 120
WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK
Sbjct: 61 WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK 120
Query: 121 KEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
KEERDLV+RLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET
Sbjct: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
Query: 181 GPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQLA 240
GPEAER EQLESGEEELVLAEYESDEEKKVAS VDEDEDDLEEEHITKIY+CSRTHSQLA
Sbjct: 181 GPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLA 240
Query: 241 QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKGAE 300
QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDV+SLGSVQLIN+RCVDMQRSRHEKKKGAE
Sbjct: 241 QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAE 300
Query: 301 EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP 360
EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP
Sbjct: 301 EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP 360
Query: 361 AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTTTSMHSVEVSGSQLCQAHS 420
AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDT T MHSVEVSGSQLCQAHS
Sbjct: 361 AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHS 420
Query: 421 QLLQYMERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGMELKTIND 480
QLLQY+ERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTG ELKTIND
Sbjct: 421 QLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTIND 480
Query: 481 FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR 540
FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR
Sbjct: 481 FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR 540
Query: 541 TTEALAAPADESQASVPQPASPLMHIEGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL 600
TTEALAAPADESQAS +PASPLMHI+GFLAALTTANQDGRVILSRQGSLSQSTLKFLLL
Sbjct: 541 TTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL 600
Query: 601 NPAVHFAQVVKECRAVVIAGGTMQPVSNFRQQLLACAGVEAERVVEFSCGHVIPPDNILP 660
NPAVHFAQVVKECRAVVIAGGTMQPVS+FRQQLLACAGVEAERVVEFSCGHVIPPDNILP
Sbjct: 601 NPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILP 660
Query: 661 LVICSGVSNQPLEFTFQKRDLPQMMDEVGRILCNLCGVVSGGVVCFFPSYEYLRQVHAHW 720
LVICSG+SNQPLEFTFQKR+LPQMMDEVGRILCNLCGVV GGVVCFFPSYEYLRQVHAHW
Sbjct: 661 LVICSGISNQPLEFTFQKRELPQMMDEVGRILCNLCGVVPGGVVCFFPSYEYLRQVHAHW 720
Query: 721 EKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSRCLQACGQERGPVTGALLLSVVGGKMS 780
EKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSRC+QACGQERG VTGALLLSVVGGKMS
Sbjct: 721 EKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGALLLSVVGGKMS 780
Query: 781 EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAHPGKALVENLCMKA 840
EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQA PGKALVENLCMKA
Sbjct: 781 EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAPPGKALVENLCMKA 840
Query: 841 VNQSIGRAIRHQKDFASIVLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR 900
VNQSIGRAIRHQKDFAS+VLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR
Sbjct: 841 VNQSIGRAIRHQKDFASVVLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR 900
Query: 901 EKSASS 906
EKSASS
Sbjct: 901 EKSASS 906
>gi|100913204 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
isoform 2 [Homo sapiens]
Length = 856
Score = 1621 bits (4197), Expect = 0.0
Identities = 835/906 (92%), Positives = 847/906 (93%), Gaps = 50/906 (5%)
Query: 1 MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS 60
MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS
Sbjct: 1 MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS 60
Query: 61 WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK 120
WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK
Sbjct: 61 WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK 120
Query: 121 KEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
KEERDLV+RLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET
Sbjct: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
Query: 181 GPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQLA 240
GPEAER EQLESGEEELVLAEYESDEEKKVAS VDEDEDDLEEEHITKIY+CSRTHSQLA
Sbjct: 181 GPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLA 240
Query: 241 QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKGAE 300
QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDV+SLGSVQLIN+RCVDMQRSRHEKKKGAE
Sbjct: 241 QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAE 300
Query: 301 EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP 360
EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP
Sbjct: 301 EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP 360
Query: 361 AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTTTSMHSVEVSGSQLCQAHS 420
AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDT T MHSVEVSGSQLCQAHS
Sbjct: 361 AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHS 420
Query: 421 QLLQYMERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGMELKTIND 480
QLLQY+ERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTG ELKTIND
Sbjct: 421 QLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTIND 480
Query: 481 FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR 540
FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR
Sbjct: 481 FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR 540
Query: 541 TTEALAAPADESQASVPQPASPLMHIEGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL 600
TTEALAAPADESQAS +PASPLMHI+GFLAALTTANQDGRVILSRQGSLSQSTLKFLLL
Sbjct: 541 TTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL 600
Query: 601 NPAVHFAQVVKECRAVVIAGGTMQPVSNFRQQLLACAGVEAERVVEFSCGHVIPPDNILP 660
NPAVHFAQVVKECRAVVIAGGTMQPVS+FRQQLLACAGVEAERVVEFSCGHVIPPDNILP
Sbjct: 601 NPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILP 660
Query: 661 LVICSGVSNQPLEFTFQKRDLPQMMDEVGRILCNLCGVVSGGVVCFFPSYEYLRQVHAHW 720
LVICSG+SNQPLEFTFQKR+LPQM
Sbjct: 661 LVICSGISNQPLEFTFQKRELPQM------------------------------------ 684
Query: 721 EKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSRCLQACGQERGPVTGALLLSVVGGKMS 780
IFQEPKSAHQVEQVLLAYSRC+QACGQERG VTGALLLSVVGGKMS
Sbjct: 685 --------------IFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGALLLSVVGGKMS 730
Query: 781 EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAHPGKALVENLCMKA 840
EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQA PGKALVENLCMKA
Sbjct: 731 EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAPPGKALVENLCMKA 790
Query: 841 VNQSIGRAIRHQKDFASIVLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR 900
VNQSIGRAIRHQKDFAS+VLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR
Sbjct: 791 VNQSIGRAIRHQKDFASVVLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR 850
Query: 901 EKSASS 906
EKSASS
Sbjct: 851 EKSASS 856
>gi|132566527 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
isoform 3 [Homo sapiens]
Length = 970
Score = 1586 bits (4106), Expect = 0.0
Identities = 802/829 (96%), Positives = 813/829 (98%)
Query: 1 MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS 60
MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS
Sbjct: 1 MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS 60
Query: 61 WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK 120
WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK
Sbjct: 61 WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK 120
Query: 121 KEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
KEERDLV+RLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET
Sbjct: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
Query: 181 GPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQLA 240
GPEAER EQLESGEEELVLAEYESDEEKKVAS VDEDEDDLEEEHITKIY+CSRTHSQLA
Sbjct: 181 GPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLA 240
Query: 241 QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKGAE 300
QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDV+SLGSVQLIN+RCVDMQRSRHEKKKGAE
Sbjct: 241 QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAE 300
Query: 301 EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP 360
EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP
Sbjct: 301 EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP 360
Query: 361 AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTTTSMHSVEVSGSQLCQAHS 420
AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDT T MHSVEVSGSQLCQAHS
Sbjct: 361 AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHS 420
Query: 421 QLLQYMERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGMELKTIND 480
QLLQY+ERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTG ELKTIND
Sbjct: 421 QLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTIND 480
Query: 481 FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR 540
FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR
Sbjct: 481 FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR 540
Query: 541 TTEALAAPADESQASVPQPASPLMHIEGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL 600
TTEALAAPADESQAS +PASPLMHI+GFLAALTTANQDGRVILSRQGSLSQSTLKFLLL
Sbjct: 541 TTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL 600
Query: 601 NPAVHFAQVVKECRAVVIAGGTMQPVSNFRQQLLACAGVEAERVVEFSCGHVIPPDNILP 660
NPAVHFAQVVKECRAVVIAGGTMQPVS+FRQQLLACAGVEAERVVEFSCGHVIPPDNILP
Sbjct: 601 NPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILP 660
Query: 661 LVICSGVSNQPLEFTFQKRDLPQMMDEVGRILCNLCGVVSGGVVCFFPSYEYLRQVHAHW 720
LVICSG+SNQPLEFTFQKR+LPQMMDEVGRILCNLCGVV GGVVCFFPSYEYLRQVHAHW
Sbjct: 661 LVICSGISNQPLEFTFQKRELPQMMDEVGRILCNLCGVVPGGVVCFFPSYEYLRQVHAHW 720
Query: 721 EKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSRCLQACGQERGPVTGALLLSVVGGKMS 780
EKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSRC+QACGQERG VTGALLLSVVGGKMS
Sbjct: 721 EKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGALLLSVVGGKMS 780
Query: 781 EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAHPG 829
EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTL PG G
Sbjct: 781 EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLSPRPGTPREG 829
>gi|239755744 PREDICTED: similar to Putative ATP-dependent RNA
helicase DDX11-like protein [Homo sapiens]
Length = 223
Score = 435 bits (1119), Expect = e-122
Identities = 218/223 (97%), Positives = 219/223 (98%)
Query: 684 MMDEVGRILCNLCGVVSGGVVCFFPSYEYLRQVHAHWEKGGLLGRLAARKKIFQEPKSAH 743
MMDEVGRILCNLC VVSGGVVCFFPSYEYLRQVHAHWEKGGLLGRLAARKKIFQEPKSAH
Sbjct: 1 MMDEVGRILCNLCVVVSGGVVCFFPSYEYLRQVHAHWEKGGLLGRLAARKKIFQEPKSAH 60
Query: 744 QVEQVLLAYSRCLQACGQERGPVTGALLLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNI 803
QVEQVLLAYSRC+QACGQERG VT ALLLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNI
Sbjct: 61 QVEQVLLAYSRCIQACGQERGQVTEALLLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNI 120
Query: 804 RSAELQEKMAYLDQTLPRAPGQAHPGKALVENLCMKAVNQSIGRAIRHQKDFASIVLLDQ 863
RSAELQEKMAYLDQTLPRAPGQA PGKALVENLCMKAVNQSIGRAIRHQKDFASIVLLDQ
Sbjct: 121 RSAELQEKMAYLDQTLPRAPGQAPPGKALVENLCMKAVNQSIGRAIRHQKDFASIVLLDQ 180
Query: 864 RYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHREKSASS 906
RYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHREKSASS
Sbjct: 181 RYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHREKSASS 223
>gi|239755742 PREDICTED: similar to DEAD/H (Asp-Glu-Ala-Asp/His) box
polypeptide 11 (CHL1-like helicase homolog, S.
cerevisiae) [Homo sapiens]
Length = 282
Score = 319 bits (818), Expect = 6e-87
Identities = 163/173 (94%), Positives = 163/173 (94%)
Query: 45 PTGTGKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGT 104
P GKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGT
Sbjct: 39 PAKKGKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGT 98
Query: 105 PRPAGEPAWVTQFVQKKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEE 164
PRPAGEPAWVTQFVQKKEERDLVNRLK EQARRKQREERLQQLQHRVQLKYAAKRLRQEE
Sbjct: 99 PRPAGEPAWVTQFVQKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEE 158
Query: 165 EERENLLRLSREMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDED 217
EE ENLLRLSREMLETGPEAE EQLESGEEELVLAEYESDEEKKVASG D
Sbjct: 159 EETENLLRLSREMLETGPEAEWLEQLESGEEELVLAEYESDEEKKVASGAPSD 211
>gi|14042978 BRCA1 interacting protein C-terminal helicase 1 [Homo
sapiens]
Length = 1249
Score = 271 bits (692), Expect = 3e-72
Identities = 235/939 (25%), Positives = 432/939 (46%), Gaps = 106/939 (11%)
Query: 8 VGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALSWLRDFEQ 67
+G + FP+ Y Q M + R L + + + ESPTG+GKSL+L+C AL+W +
Sbjct: 10 IGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSALAWQQSLSG 69
Query: 68 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGA--------AGTPR-------PAGEPA 112
K +E + ++ + L +C GT R P E
Sbjct: 70 KPADEG----------VSEKAEVQLSCCCACHSKDFTNNDMNQGTSRHFNYPSTPPSERN 119
Query: 113 WVTQFVQKKEERD-LVNRLKAEQARRKQREER--LQQLQHRVQLKYAAKRLRQEEEEREN 169
+ Q E+ L +L A++ R+E Q + R++ +++R+
Sbjct: 120 GTSSTCQDSPEKTTLAAKLSAKKQASIYRDENDDFQVEKKRIRPLETTQQIRKRHCFGTE 179
Query: 170 LLRLSREMLETGPEAERPEQLES----------GEEELVLAEYESDEEKKVASGVDEDED 219
+ L ++ ++G + LE G + ++ ++ + +D
Sbjct: 180 VHNLDAKV-DSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHT 238
Query: 220 DLEEEHITKIYHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQ 279
+ I KIY +RTH Q+AQ E++++ + V + L SR + CV+ +V +G+
Sbjct: 239 G--KSKIPKIYFGTRTHKQIAQITRELRRTAYS-GVPMTILSSRDHTCVHPEV--VGNFN 293
Query: 280 LINNRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYN-----HEQMGLLRDEALAEV 334
N +C+++ ++ K +C FY+ +Q L + + +
Sbjct: 294 R-NEKCMELLDGKNGK------------------SCYFYHGVHKISDQHTLQTFQGMCKA 334
Query: 335 KDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDE 394
D+E+L++LGK+ +ACPYY +R I A ++ PY LL A R++ + L++QVVI+DE
Sbjct: 335 WDIEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQIRESMDLNLKEQVVILDE 394
Query: 395 AHNLIDTTTSMHSVEVSGSQLCQAHSQLLQYMERYGKRLKAKNLMYLKQILYLLEKFVAV 454
AHN+ D S V+ QL A +L + ++ K+ L+ + L ++
Sbjct: 395 AHNIEDCARESASYSVTEVQLRFARDELDSMVNN---NIRKKDHEPLRAVCCSLINWLEA 451
Query: 455 LGGNIKQNPNTQSLS-QTGME-LKTINDFLFQSQIDNINLFKVQRYCEKSMISRKLFGFT 512
+ + + +G E L T++ + I +K ++G
Sbjct: 452 NAEYLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKE 511
Query: 513 E-RYGAVFSSREQPKLAGFQQFLQSLQPRTTEALAAPADESQASVPQPASPLMHIEGFLA 571
E R V S+ Q L G L L + + AD+ + ++ Q S I+
Sbjct: 512 EAREVPVISASTQIMLKGLFMVLDYLFRQNSRF----ADDYKIAIQQTYSWTNQID---- 563
Query: 572 ALTTANQDGRVILSRQGSLSQS-----TLKFLLLNPAVHFAQVVKECRAVVIAGGTMQPV 626
++++G ++L + S+ L F LNPAV F+ + + + +V+ GT+ P+
Sbjct: 564 ---ISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPM 620
Query: 627 SNFRQQLLACAGVEAERVVEFSCGHVIPPDNILPLVICSGVSNQPLEFTFQKRDLPQMMD 686
+F +L GV ++ H+I + I SG + L TFQ + + D
Sbjct: 621 KSFSSEL----GVTF--TIQLEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQD 674
Query: 687 EVGRILCNLCGVVSGGVVCFFPSYEYLRQVHAHWEKGGLLGRLAARKKIFQEPKSAHQV- 745
EVG +L ++C VS G++CF PSY+ L ++ W GL L K + EP+ +
Sbjct: 675 EVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKTN 734
Query: 746 -EQVLLAYSRCLQACGQERGPVTGALLLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNIR 804
+++L Y ++ G++ GALL++V GK+SEG++FSD+ R V+ +G+PFPN++
Sbjct: 735 FDELLQVYYDAIKYKGEK----DGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVK 790
Query: 805 SAELQEKMAYLDQTLPRAPGQAHPGKALVENLCMKAVNQSIGRAIRHQKDFASIVLLDQR 864
+++ K Y D + G PG+ E +A+NQ++GR IRH+ D+ +++L+D R
Sbjct: 791 DLQVELKRQYNDHH-SKLRGLL-PGRQWYEIQAYRALNQALGRCIRHRNDWGALILVDDR 848
Query: 865 YARPP--VLAKLPAWIRARVEVKATFGPAIAAVQKFHRE 901
+ P ++ L W+R +++ +TF A+ ++ +F ++
Sbjct: 849 FRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKK 887
>gi|91984775 regulator of telomere elongation helicase 1 isoform 2
[Homo sapiens]
Length = 1300
Score = 230 bits (586), Expect = 5e-60
Identities = 187/701 (26%), Positives = 314/701 (44%), Gaps = 82/701 (11%)
Query: 226 ITKIYHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRC 285
I KI + SRTHSQL Q ++E++ + + V + LGSR+ LC++ +V+ S L + C
Sbjct: 106 IPKIIYASRTHSQLTQVINELRNTSYRPKVCV--LGSREQLCIHPEVKKQESNHLQIHLC 163
Query: 286 VDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGK 345
R++ +C FYN+ + L E + + D+E L+ G
Sbjct: 164 ---------------------RKKVASRSCHFYNNVEEKSLEQELASPILDIEDLVKSGS 202
Query: 346 EARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNL------- 398
+ R CPYY SR A ++ +PY LL A +R+A I L+ VVI DEAHN+
Sbjct: 203 KHRVCPYYLSRNLKQQADIIFMPYNYLLDAKSRRAHNIDLKGTVVIFDEAHNVEKMCEES 262
Query: 399 -------------IDTTTSMHSVEVSGSQLCQAHSQLLQYMERYGKRLKAKNLMYLKQIL 445
+D + + +Q + H + G ++ +++ LK IL
Sbjct: 263 ASFDLTPHDLASGLDVIDQVLEEQTKAAQQGEPHPEFSADSPSPGLNMELEDIAKLKMIL 322
Query: 446 YLLEKFVAVLGGNIKQNPNTQSLSQTGMELKTINDFLFQSQIDNINLFKVQRYCEKSMIS 505
LE + ++ + +++ G ++F+ + F+ + C +
Sbjct: 323 LRLEGAIDA----VELPGDDSGVTKPG-------SYIFELFAEAQITFQTKG-CILDSLD 370
Query: 506 RKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPRTTEALAAPADESQASVPQPASPLMH 565
+ + R G ++ KLA Q + S+ P + + S A + S +H
Sbjct: 371 QIIQHLAGRAGVFTNTAGLQKLADIIQIVFSVDP------SEGSPGSPAGLGALQSYKVH 424
Query: 566 IEGFLAALTTANQD---GRVILSRQGSLSQSTLKFLLLNPAVHFAQVVKE-CRAVVIAGG 621
I TA + ++G + L + +P ++V++ R++++ G
Sbjct: 425 IHPDAGHRRTAQRSDAWSTTAARKRGKV----LSYWCFSPGHSMHELVRQGVRSLILTSG 480
Query: 622 TMQPVSNFRQQLLACAGVEAERVVEFSCGHVIPPDNILPLVICSGVSNQPLEFTFQKRDL 681
T+ PVS+F ++ V E H+I I V+ G L F +R
Sbjct: 481 TLAPVSSFALEMQIPFPVCLENP------HIIDKHQIWVGVVPRGPDGAQLSSAFDRRFS 534
Query: 682 PQMMDEVGRILCNLCGVVSGGVVCFFPSYEYLRQVHAHWEKGGLLGRLAARKKIFQEPKS 741
+ + +G+ L N+ VV G++ FFPSY + + W L ++ A K +F EP+S
Sbjct: 535 EECLSSLGKALGNIARVVPYGLLIFFPSYPVMEKSLEFWRARDLARKMEALKPLFVEPRS 594
Query: 742 AHQVEQVLLAYSRCLQACGQERGPVTGALLLSVVGGKMSEGINFSDNLGRCVVMVGMPFP 801
+ + AY + A G TGA L+V GK SEG++FSD GR V++ G+P+P
Sbjct: 595 KGSFSETISAYYARVAAPGS-----TGATFLAVCRGKASEGLDFSDTNGRGVIVTGLPYP 649
Query: 802 NIRSAELQEKMAYLDQTLPR--APGQAHPGKALVENLCMKAVNQSIGRAIRHQKDFASIV 859
+ KM +LD+ + A GQ G+ +AVNQ+IGR IRH++D+ ++
Sbjct: 650 PRMDPRVVLKMQFLDEMKGQGGAGGQFLSGQEWYRQQASRAVNQAIGRVIRHRQDYGAVF 709
Query: 860 LLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR 900
L D R+A A+LP+W+R V V FG I V +F R
Sbjct: 710 LCDHRFAFADARAQLPSWVRPHVRVYDNFGHVIRDVAQFFR 750
Score = 57.4 bits (137), Expect = 6e-08
Identities = 35/94 (37%), Positives = 49/94 (52%), Gaps = 10/94 (10%)
Query: 15 FPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALSW---LRDFEQKKRE 71
FPF PY Q+++M ++ L+ GI ESPTGTGK+L L+C L+W LRD +
Sbjct: 13 FPFQPYKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAWREHLRDGISAR-- 70
Query: 72 EEARLLETGTGPLHDEKDESLCLSSSCEGAAGTP 105
++ E G L D +L + AAG P
Sbjct: 71 ---KIAERAQGELF--PDRALSSWGNAAAAAGDP 99
>gi|7706541 regulator of telomere elongation helicase 1 isoform 1
[Homo sapiens]
Length = 1219
Score = 230 bits (586), Expect = 5e-60
Identities = 187/701 (26%), Positives = 314/701 (44%), Gaps = 82/701 (11%)
Query: 226 ITKIYHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRC 285
I KI + SRTHSQL Q ++E++ + + V + LGSR+ LC++ +V+ S L + C
Sbjct: 106 IPKIIYASRTHSQLTQVINELRNTSYRPKVCV--LGSREQLCIHPEVKKQESNHLQIHLC 163
Query: 286 VDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGK 345
R++ +C FYN+ + L E + + D+E L+ G
Sbjct: 164 ---------------------RKKVASRSCHFYNNVEEKSLEQELASPILDIEDLVKSGS 202
Query: 346 EARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNL------- 398
+ R CPYY SR A ++ +PY LL A +R+A I L+ VVI DEAHN+
Sbjct: 203 KHRVCPYYLSRNLKQQADIIFMPYNYLLDAKSRRAHNIDLKGTVVIFDEAHNVEKMCEES 262
Query: 399 -------------IDTTTSMHSVEVSGSQLCQAHSQLLQYMERYGKRLKAKNLMYLKQIL 445
+D + + +Q + H + G ++ +++ LK IL
Sbjct: 263 ASFDLTPHDLASGLDVIDQVLEEQTKAAQQGEPHPEFSADSPSPGLNMELEDIAKLKMIL 322
Query: 446 YLLEKFVAVLGGNIKQNPNTQSLSQTGMELKTINDFLFQSQIDNINLFKVQRYCEKSMIS 505
LE + ++ + +++ G ++F+ + F+ + C +
Sbjct: 323 LRLEGAIDA----VELPGDDSGVTKPG-------SYIFELFAEAQITFQTKG-CILDSLD 370
Query: 506 RKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPRTTEALAAPADESQASVPQPASPLMH 565
+ + R G ++ KLA Q + S+ P + + S A + S +H
Sbjct: 371 QIIQHLAGRAGVFTNTAGLQKLADIIQIVFSVDP------SEGSPGSPAGLGALQSYKVH 424
Query: 566 IEGFLAALTTANQD---GRVILSRQGSLSQSTLKFLLLNPAVHFAQVVKE-CRAVVIAGG 621
I TA + ++G + L + +P ++V++ R++++ G
Sbjct: 425 IHPDAGHRRTAQRSDAWSTTAARKRGKV----LSYWCFSPGHSMHELVRQGVRSLILTSG 480
Query: 622 TMQPVSNFRQQLLACAGVEAERVVEFSCGHVIPPDNILPLVICSGVSNQPLEFTFQKRDL 681
T+ PVS+F ++ V E H+I I V+ G L F +R
Sbjct: 481 TLAPVSSFALEMQIPFPVCLENP------HIIDKHQIWVGVVPRGPDGAQLSSAFDRRFS 534
Query: 682 PQMMDEVGRILCNLCGVVSGGVVCFFPSYEYLRQVHAHWEKGGLLGRLAARKKIFQEPKS 741
+ + +G+ L N+ VV G++ FFPSY + + W L ++ A K +F EP+S
Sbjct: 535 EECLSSLGKALGNIARVVPYGLLIFFPSYPVMEKSLEFWRARDLARKMEALKPLFVEPRS 594
Query: 742 AHQVEQVLLAYSRCLQACGQERGPVTGALLLSVVGGKMSEGINFSDNLGRCVVMVGMPFP 801
+ + AY + A G TGA L+V GK SEG++FSD GR V++ G+P+P
Sbjct: 595 KGSFSETISAYYARVAAPGS-----TGATFLAVCRGKASEGLDFSDTNGRGVIVTGLPYP 649
Query: 802 NIRSAELQEKMAYLDQTLPR--APGQAHPGKALVENLCMKAVNQSIGRAIRHQKDFASIV 859
+ KM +LD+ + A GQ G+ +AVNQ+IGR IRH++D+ ++
Sbjct: 650 PRMDPRVVLKMQFLDEMKGQGGAGGQFLSGQEWYRQQASRAVNQAIGRVIRHRQDYGAVF 709
Query: 860 LLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR 900
L D R+A A+LP+W+R V V FG I V +F R
Sbjct: 710 LCDHRFAFADARAQLPSWVRPHVRVYDNFGHVIRDVAQFFR 750
Score = 57.4 bits (137), Expect = 6e-08
Identities = 35/94 (37%), Positives = 49/94 (52%), Gaps = 10/94 (10%)
Query: 15 FPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALSW---LRDFEQKKRE 71
FPF PY Q+++M ++ L+ GI ESPTGTGK+L L+C L+W LRD +
Sbjct: 13 FPFQPYKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAWREHLRDGISAR-- 70
Query: 72 EEARLLETGTGPLHDEKDESLCLSSSCEGAAGTP 105
++ E G L D +L + AAG P
Sbjct: 71 ---KIAERAQGELF--PDRALSSWGNAAAAAGDP 99
>gi|15834617 excision repair cross-complementing rodent repair
deficiency, complementation group 2 protein isoform 1
[Homo sapiens]
Length = 760
Score = 124 bits (312), Expect = 3e-28
Identities = 99/362 (27%), Positives = 164/362 (45%), Gaps = 46/362 (12%)
Query: 561 SPLMHIEGFLAALTTANQDGRVILS----RQGSLSQSTLKFLLLNPAVHFAQVVKECRAV 616
SPL + F ++T + +I+ R +++ L F ++ ++ V + ++V
Sbjct: 395 SPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSV 454
Query: 617 VIAGGTMQPVS------NFRQQLLACAGVEAERVVEFSCGHVIPPDNILPLVICSGVSNQ 670
+I GT+ P+ +F +A + RV + P++I G
Sbjct: 455 IITSGTLSPLDIYPKILDFHPVTMATFTMTLARVC------------LCPMIIGRGNDQV 502
Query: 671 PLEFTFQKRDLPQMMDEVGRILCNLCGVVSGGVVCFFPSYEYLRQVHAHWEKGGLLGRLA 730
+ F+ R+ ++ G +L + VV G+V FF SY+Y+ A W + G+L +
Sbjct: 503 AISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQ 562
Query: 731 ARKKIFQEPKSAHQVEQVLLAYSRCLQACGQERGPVTGALLLSVVGGKMSEGINFSDNLG 790
K +F E + + L Y +AC R GA+LLSV GK+SEGI+F + G
Sbjct: 563 RNKLLFIETQDGAETSVALEKYQ---EACENGR----GAILLSVARGKVSEGIDFVHHYG 615
Query: 791 RCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAHPGKALVENLCMKAVNQSIGRAIR 850
R V+M G+P+ +S L+ ++ YL R Q L + M+ Q +GRAIR
Sbjct: 616 RAVIMFGVPYVYTQSRILKARLEYL-----RDQFQIRENDFLTFD-AMRHAAQCVGRAIR 669
Query: 851 HQKDFASIVLLDQRYARPPVLAKLPAWIR-----ARVEVKATFGPAIA------AVQKFH 899
+ D+ +V D+R+AR KLP WI+ A + + G +A Q FH
Sbjct: 670 GKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFH 729
Query: 900 RE 901
RE
Sbjct: 730 RE 731
Score = 66.2 bits (160), Expect = 1e-10
Identities = 54/210 (25%), Positives = 95/210 (45%), Gaps = 20/210 (9%)
Query: 226 ITKIYHCSRTHSQLAQFVHEVKK------SPFGKDVRLV--SLGSRQNLCVNEDVRSLGS 277
+TK+ +CSRT ++ + + E++K G+ + + +L SR+NLC++ +V L
Sbjct: 67 VTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRF 126
Query: 278 VQLINNRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDM 337
+ ++ +C + S + + P C FY A + ++
Sbjct: 127 GKDVDGKCHSLTASYVRAQYQHDTSLPH---------CRFYEEFDAHGREVPLPAGIYNL 177
Query: 338 EQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRL-QDQVVIIDEAH 396
+ L ALG+ CPY+ +R +I A +VV Y LL L + VV+ DEAH
Sbjct: 178 DDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAH 237
Query: 397 NLIDTTTSMHSVEVSGSQL--CQAHSQLLQ 424
N+ + SV ++ L CQ + + LQ
Sbjct: 238 NIDNVCIDSMSVNLTRRTLDRCQGNLETLQ 267
Score = 41.6 bits (96), Expect = 0.003
Identities = 20/55 (36%), Positives = 35/55 (63%), Gaps = 1/55 (1%)
Query: 11 IHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALSWLRDF 65
++FP+ + Y Q +M EL R L+A G+ E P+GTGK++SL+ +++ R +
Sbjct: 10 VYFPYDYI-YPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAY 63
>gi|195947407 excision repair cross-complementing rodent repair
deficiency, complementation group 2 protein isoform 2
[Homo sapiens]
Length = 405
Score = 66.2 bits (160), Expect = 1e-10
Identities = 54/210 (25%), Positives = 95/210 (45%), Gaps = 20/210 (9%)
Query: 226 ITKIYHCSRTHSQLAQFVHEVKK------SPFGKDVRLV--SLGSRQNLCVNEDVRSLGS 277
+TK+ +CSRT ++ + + E++K G+ + + +L SR+NLC++ +V L
Sbjct: 43 VTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRF 102
Query: 278 VQLINNRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDM 337
+ ++ +C + S + + P C FY A + ++
Sbjct: 103 GKDVDGKCHSLTASYVRAQYQHDTSLPH---------CRFYEEFDAHGREVPLPAGIYNL 153
Query: 338 EQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRL-QDQVVIIDEAH 396
+ L ALG+ CPY+ +R +I A +VV Y LL L + VV+ DEAH
Sbjct: 154 DDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAH 213
Query: 397 NLIDTTTSMHSVEVSGSQL--CQAHSQLLQ 424
N+ + SV ++ L CQ + + LQ
Sbjct: 214 NIDNVCIDSMSVNLTRRTLDRCQGNLETLQ 243
Score = 34.7 bits (78), Expect = 0.41
Identities = 16/39 (41%), Positives = 26/39 (66%)
Query: 27 MAELYRVLEAGKIGIFESPTGTGKSLSLICGALSWLRDF 65
M EL R L+A G+ E P+GTGK++SL+ +++ R +
Sbjct: 1 MRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAY 39
>gi|239743668 PREDICTED: hypothetical protein XP_002342944 [Homo
sapiens]
Length = 133
Score = 62.4 bits (150), Expect = 2e-09
Identities = 37/76 (48%), Positives = 43/76 (56%), Gaps = 10/76 (13%)
Query: 779 MSEGINFSDNLG------RCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQA----HP 828
MSE INFSDNLG RCVVM GMPFP+IRS ELQ+ A LD L P A HP
Sbjct: 1 MSESINFSDNLGQLLSPPRCVVMPGMPFPSIRSPELQKTTADLDHNLVSVPSVAESLHHP 60
Query: 829 GKALVENLCMKAVNQS 844
+ C+ + +S
Sbjct: 61 EITFLTAFCLPSFTRS 76
>gi|239745348 PREDICTED: hypothetical protein XP_002343431 [Homo
sapiens]
Length = 133
Score = 61.6 bits (148), Expect = 3e-09
Identities = 37/76 (48%), Positives = 43/76 (56%), Gaps = 10/76 (13%)
Query: 779 MSEGINFSDNLG------RCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQA----HP 828
MSE INFS NLG RCVVM GMPFP+IRS ELQ+ A LD TL P A HP
Sbjct: 1 MSESINFSHNLGQLLSPPRCVVMPGMPFPSIRSPELQKTTADLDHTLVSVPSVAESLHHP 60
Query: 829 GKALVENLCMKAVNQS 844
+ C+ + +S
Sbjct: 61 EITFLTAFCLPSFTRS 76
>gi|239740967 PREDICTED: hypothetical protein XP_002342051 [Homo
sapiens]
Length = 133
Score = 61.6 bits (148), Expect = 3e-09
Identities = 37/76 (48%), Positives = 43/76 (56%), Gaps = 10/76 (13%)
Query: 779 MSEGINFSDNLG------RCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQA----HP 828
MSE INFS NLG RCVVM GMPFP+IRS ELQ+ A LD TL P A HP
Sbjct: 1 MSESINFSHNLGQLLSPPRCVVMPGMPFPSIRSPELQKTTADLDHTLVSVPSVAESLHHP 60
Query: 829 GKALVENLCMKAVNQS 844
+ C+ + +S
Sbjct: 61 EITFLTAFCLPSFTRS 76
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 50.8 bits (120), Expect = 6e-06
Identities = 44/195 (22%), Positives = 90/195 (46%), Gaps = 16/195 (8%)
Query: 121 KEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
+EE + + +L+ ++ RR+++EE QQ + R + + R +QEEE RE + E
Sbjct: 272 QEEEEQLRKLERQELRRERQEEEQQQQRLRREQQL---RRKQEEERRE-------QQEER 321
Query: 181 GPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQLA 240
+ ER EQ E E+ + E E E+++ E E++ E+ + + R QL
Sbjct: 322 REQQERREQQEERREQQLRREQEERREQQLRR---EQEEERREQQLRREQEEERREQQLR 378
Query: 241 QFVHEVKKSPFGKDVRL---VSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKK 297
+ ++ ++ +L L Q L + +R ++ + + RHE+K
Sbjct: 379 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKH 438
Query: 298 GAEEEKPKRRRQEKQ 312
E + + +R++++
Sbjct: 439 EQERREQRLKREQEE 453
Score = 49.3 bits (116), Expect = 2e-05
Identities = 52/228 (22%), Positives = 102/228 (44%), Gaps = 16/228 (7%)
Query: 120 KKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLE 179
+++ERD R + +Q RR++RE + Q + +++ + ++ R+EE+ R+ + E
Sbjct: 1685 RRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQE 1744
Query: 180 TGPEAERPEQLESGEEELVLAEYESD----EEKKVASGVDEDEDDLEEEHITKIYHCSRT 235
+ EQL EE L E D EE+++ + +E L + + + R
Sbjct: 1745 RYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQ--EREEQQLRSQESDRKF---RE 1799
Query: 236 HSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVD----MQRS 291
QL Q E + P +D + + L + E + L + R + ++S
Sbjct: 1800 EEQLRQEREEQQLRPQQRDGKY--RWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKS 1857
Query: 292 RHEKKKGAEEEKPKRRRQ-EKQAACPFYNHEQMGLLRDEALAEVKDME 338
R E+++ +EE+ KRR++ E++ +Q R + E+K E
Sbjct: 1858 RREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQE 1905
Score = 48.9 bits (115), Expect = 2e-05
Identities = 62/275 (22%), Positives = 115/275 (41%), Gaps = 22/275 (8%)
Query: 62 LRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKK 121
LR+ +K+R +E L E+++ L R + + Q ++
Sbjct: 1034 LREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQL 1093
Query: 122 EERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEE----ERENLLRLSREM 177
+ R + E+ R+ + EE LQQ + ++ + KR RQE E E E + + ++
Sbjct: 1094 LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQL 1153
Query: 178 LETGPEAERPEQLE---------SGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITK 228
L PE R ++LE EEE +L E E ++ ++ +E++L+ + +
Sbjct: 1154 LREEPEKRRRQELERQYREEEELQQEEEQLLRE-EQEKRRQERERQYREEEELQRQKRKQ 1212
Query: 229 IYHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDM 288
Y S L ++ E +K +D ++ G NE R L QL + +
Sbjct: 1213 RYRDEDQRSDL-KWQWEPEKENAVRDNKVYCKGRE-----NEQFRQLEDSQLRDRQ--SQ 1264
Query: 289 QRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQM 323
Q +H + E ++ + RR+ +Q F EQ+
Sbjct: 1265 QDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQL 1299
Score = 48.5 bits (114), Expect = 3e-05
Identities = 53/197 (26%), Positives = 90/197 (45%), Gaps = 22/197 (11%)
Query: 119 QKKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
+++E RD + LK E+ RR+QR +R Q+ + +LK ++EE RE RL RE
Sbjct: 570 EQEERRDQL--LKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQ--RLKRE-- 623
Query: 179 ETGPEAERPEQLESGEEELVLAEYE---SDEEKKVASGVDEDEDDLEEEHITKIYHCSRT 235
PE ER +QL EE+ + + +E++ E+E++ E+ + + + R
Sbjct: 624 --EPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERR 681
Query: 236 HSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEK 295
+LA+ E + R+ S + + + + S R + QR R E
Sbjct: 682 EQELAEEEQEQARE------RIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQE- 734
Query: 296 KKGAEEEKPKRRRQEKQ 312
+EEK +RR E Q
Sbjct: 735 ----QEEKRRRRESELQ 747
Score = 48.1 bits (113), Expect = 4e-05
Identities = 47/197 (23%), Positives = 87/197 (44%), Gaps = 6/197 (3%)
Query: 116 QFVQKKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSR 175
Q + +EE LK E+ R++++ER +Q R Q + +RL+++EEE RL
Sbjct: 475 QLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRS 534
Query: 176 EMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRT 235
E + ER EQL EEE L E E E++ + + L+ E + R
Sbjct: 535 EQQLRREQEERREQLLKREEEKRL-EQERREQRLKREQEERRDQLLKREEERRQQRLKR- 592
Query: 236 HSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEK 295
Q + +K+ + RL R+ E+ QL+ + + +R + +
Sbjct: 593 -EQEERLEQRLKRE---EVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLR 648
Query: 296 KKGAEEEKPKRRRQEKQ 312
++ E + + +R+E++
Sbjct: 649 REQQERREQRLKREEEE 665
Score = 48.1 bits (113), Expect = 4e-05
Identities = 50/202 (24%), Positives = 93/202 (46%), Gaps = 21/202 (10%)
Query: 116 QFVQKKEERDLVNRLKAEQARR---KQREERLQQLQHRVQLKYAAKRLRQEEEERENLLR 172
Q ++++EER RLK EQ R + + E +++L+ + + KR EEE R+ LL+
Sbjct: 577 QLLKREEER-RQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLK 635
Query: 173 LSREMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDED--EDDLEEEHITKIY 230
S E E + R EQ E E+ L E E E+++ +E+ E +L EE +
Sbjct: 636 -SEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR 694
Query: 231 HCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQR 290
R S++ ++ +++ + ++ S +Q Q + +R
Sbjct: 695 --ERIKSRIPKWQWQLESEADARQSKVYSRPRKQ------------EGQRRRQEQEEKRR 740
Query: 291 SRHEKKKGAEEEKPKRRRQEKQ 312
R + + EEE+ R++QE++
Sbjct: 741 RRESELQWQEEERAHRQQQEEE 762
Score = 45.1 bits (105), Expect = 3e-04
Identities = 53/229 (23%), Positives = 94/229 (41%), Gaps = 17/229 (7%)
Query: 119 QKKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
Q++E R+ + +Q RR+Q+EER +Q R Q + ++LR+E+EE +L RE
Sbjct: 310 QEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ- 368
Query: 179 ETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQ 238
E ER EQ E++L + E++ E L E + R Q
Sbjct: 369 ----EEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 424
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKG 298
L + E + + R Q L ++ R + + +R + + K+
Sbjct: 425 LRREQEEERHEQKHEQER-----REQRLKREQEERRDWLKREEETERHEQERRKQQLKRD 479
Query: 299 AEEEKPKR-------RRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQL 340
EEE+ +R R+E+Q + R++ L ++ E+L
Sbjct: 480 QEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERL 528
Score = 45.1 bits (105), Expect = 3e-04
Identities = 55/240 (22%), Positives = 105/240 (43%), Gaps = 35/240 (14%)
Query: 121 KEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEE----ERENLLR---- 172
++ERD RL+ ++ RR+++E + + + +++ + ++LRQE + E E LL+
Sbjct: 1574 RQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREE 1633
Query: 173 -------LSREMLETGPEAERPEQLES---------GEEELVLAEYESDEEKKVASGVDE 216
R+ LE P+ R E+ + EEE +L E E + ++ +
Sbjct: 1634 QQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRR----QER 1689
Query: 217 DEDDLEEEHITKIYHCSRTHSQLAQFVHEVK-KSPFGKDVRLVSLGSRQNLCVNEDVRSL 275
D EEE + R Q Q + + + F ++ +L ++ L E R +
Sbjct: 1690 DRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKI 1749
Query: 276 GSVQLINNRCVDMQRSRHEK-KKGAEEEKPKRRRQEKQAAC-----PFYNHEQMGLLRDE 329
+ + + Q R E+ +K EEE+ ++ R+E+Q F EQ+ R+E
Sbjct: 1750 LEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREE 1809
Score = 44.3 bits (103), Expect = 5e-04
Identities = 57/230 (24%), Positives = 107/230 (46%), Gaps = 39/230 (16%)
Query: 120 KKEERDLVNRLKAEQARRKQ---REERLQQLQHRVQLKY---AAKRLRQEEEERENLLRL 173
++EER + +Q RR+Q RE+RL++ + +L+ + ++LR+E+EER L L
Sbjct: 492 EEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL-L 550
Query: 174 SREMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEE----EHITKI 229
RE + + R ++L+ +EE + +EE++ E E+ LE+ E + ++
Sbjct: 551 KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERL 610
Query: 230 YHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQ 289
R +L + E ++ RQ L +E+ QL + Q
Sbjct: 611 EQEERREQRLKREEPEEER--------------RQQLLKSEEQEERRQQQLRR----EQQ 652
Query: 290 RSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQ 339
R ++ K EEE+ +R +++ HE+ R++ LAE ++ EQ
Sbjct: 653 ERREQRLKREEEEERLEQRLKRE-------HEEE--RREQELAE-EEQEQ 692
Score = 44.3 bits (103), Expect = 5e-04
Identities = 51/231 (22%), Positives = 102/231 (44%), Gaps = 24/231 (10%)
Query: 116 QFVQKKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSR 175
Q +Q++EE L+ E+ +++R+E+ +Q + QL+ ++L +EE E+ R
Sbjct: 904 QLLQEEEEE-----LQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERER 958
Query: 176 EMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDL--EEEHITKIYHCS 233
+ + ++ EQL GEE E +++ + + ++E+ L EE +
Sbjct: 959 QYRKDKKLQQKEEQL-LGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWE 1017
Query: 234 RTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLI-----NNRCVDM 288
R + + + E ++ ++ L R+ E+ QL+ R ++
Sbjct: 1018 RQYRKKDELQQE-EEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076
Query: 289 QRS-------RHEKKKGAEEEKPKRRRQEKQAAC---PFYNHEQMGLLRDE 329
+R + E+++ EE KRRRQE++ C E+ LLR+E
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREE 1127
Score = 44.3 bits (103), Expect = 5e-04
Identities = 47/204 (23%), Positives = 93/204 (45%), Gaps = 11/204 (5%)
Query: 113 WVTQFVQKKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLR 172
W Q+ +K E + + EQ R++RE+R +LQ R + + L+QEEE+ R
Sbjct: 1016 WERQYRKKDELQQ-----EEEQLLREEREKR--RLQERERQYREEEELQQEEEQLLGEER 1068
Query: 173 LSREMLETGPEAERPEQLESGEEELVLAEYES-DEEKKVASGVDEDEDDLEEEHITKIYH 231
+R E + + E+L+ EE+L+ E E +++ +E+E EEE + +
Sbjct: 1069 ETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREER 1128
Query: 232 CSRTHSQL-AQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCV--DM 288
R +L Q+ E + + + R+ + R +Q + + +
Sbjct: 1129 EKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQ 1188
Query: 289 QRSRHEKKKGAEEEKPKRRRQEKQ 312
++ R E+++ EE+ +R++ KQ
Sbjct: 1189 EKRRQERERQYREEEELQRQKRKQ 1212
Score = 43.5 bits (101), Expect = 9e-04
Identities = 64/289 (22%), Positives = 122/289 (42%), Gaps = 19/289 (6%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
++ KRE+E RL + L E+ E L E P E Q + K EE++
Sbjct: 588 QRLKREQEERLEQR----LKREEVERLEQEERREQRLKREEPEEERR---QQLLKSEEQE 640
Query: 126 LVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAE 185
+ + + ++++RE+RL++ + +L+ KR +EE + L +E ++
Sbjct: 641 ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSR 700
Query: 186 RPE---QLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQLAQF 242
P+ QLES E + ++ S K+ +++++ +++ + Q
Sbjct: 701 IPKWQWQLES-EADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQ 759
Query: 243 VHEVKKS-PFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKGAEE 301
E ++ + S RQ L +R QL + ++ R ++ EE
Sbjct: 760 EEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQL----RAEERQQREQRFLPEEE 815
Query: 302 EKPKRRRQ--EKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEAR 348
EK +RRRQ E++ F E+ L R E ++++ E L +E R
Sbjct: 816 EKEQRRRQRREREKELQFLEEEEQ-LQRRERAQQLQEEEDGLQEDQERR 863
Score = 42.7 bits (99), Expect = 0.002
Identities = 48/227 (21%), Positives = 95/227 (41%), Gaps = 40/227 (17%)
Query: 120 KKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLE 179
+++ERD + + ++ R ++ E + + + ++ + ++ QEE++ R + +
Sbjct: 1495 RRQERD--RKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQD 1552
Query: 180 TGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQL 239
+ EQL EE L+ E D + + LEE+ + R Q
Sbjct: 1553 RDRKFREEEQLRQEREEQQLSRQERDRKFR-----------LEEQKV-------RRQEQE 1594
Query: 240 AQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKGA 299
+F+ + + +L +Q L D + QL+ R + Q R E+ +
Sbjct: 1595 RKFMED--------EQQLRRQEGQQQLRQERDRKFREDEQLLQER-EEQQLHRQERDRKF 1645
Query: 300 EEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKE 346
EE+P+ RRQE++ LR + + ++ EQLL G+E
Sbjct: 1646 LEEEPQLRRQEREQQ-----------LRHDRDRKFREEEQLLQEGEE 1681
Score = 42.4 bits (98), Expect = 0.002
Identities = 69/331 (20%), Positives = 139/331 (41%), Gaps = 20/331 (6%)
Query: 25 DFMAELYRVLEAGKIGIFESPTGTGKSLSLIC-GALSWLRDFEQKKREEEARLLETGTGP 83
+F+ +++V +A + ++ TG + C G S L+D +++EE+ R E
Sbjct: 73 EFLLFIFKVAQACYYALGQA-TGLDEEKRARCDGKESLLQD---RRQEEDQRRFEPRDRQ 128
Query: 84 LHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVNRLKAEQARRKQREER 143
L +E + + R E ++ ++ E+RD R + +R++ +ER
Sbjct: 129 LEEEPGQR-----RRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQER 183
Query: 144 LQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERPEQLESGE-EELVLAEY 202
++ QL+ +E + E L R RE+LE + +Q + E ++ V E
Sbjct: 184 EERRAEEEQLQSCKGHETEEFPDEEQLRR--RELLELRRKGREEKQQQRRERQDRVFQEE 241
Query: 203 ESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQLAQFV-HEVKKSPFGKDVRLVSLG 261
E E +K + + ++E+ L+EE + QL + E+++ ++ + L
Sbjct: 242 EEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLR 301
Query: 262 SRQNL--CVNEDVRSLGSVQLINNRCVDMQRSRHEKKKGAEEEKPK----RRRQEKQAAC 315
Q L E+ R + + Q R E++ E+E+ + RR QE++
Sbjct: 302 REQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERRE 361
Query: 316 PFYNHEQMGLLRDEALAEVKDMEQLLALGKE 346
EQ R++ L + + + L +E
Sbjct: 362 QQLRREQEEERREQQLRREQQLRREQQLRRE 392
Score = 42.4 bits (98), Expect = 0.002
Identities = 38/197 (19%), Positives = 88/197 (44%), Gaps = 6/197 (3%)
Query: 116 QFVQKKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSR 175
Q ++++++ +L+ EQ R+++EE + +H + + +RL++E+EER + L+
Sbjct: 405 QQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERR--EQRLKREQEERRDWLKREE 462
Query: 176 EMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRT 235
E E + R +QL+ +EE + EE++ + E L E + +
Sbjct: 463 E-TERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKR 521
Query: 236 HSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEK 295
+ + ++ + +R R+ L E+ + L + + + R +
Sbjct: 522 QEEEERLQQRLRSE---QQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQL 578
Query: 296 KKGAEEEKPKRRRQEKQ 312
K EE + +R ++E++
Sbjct: 579 LKREEERRQQRLKREQE 595
Score = 42.0 bits (97), Expect = 0.003
Identities = 52/221 (23%), Positives = 96/221 (43%), Gaps = 26/221 (11%)
Query: 116 QFVQKKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSR 175
Q +Q++EE+ L + ++ RK REE L+ + + +RLR++E ER+ L +
Sbjct: 1343 QLLQEREEQPL----RRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ 1398
Query: 176 EMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRT 235
+ ER +QL + + EE++ S + D EEE + R
Sbjct: 1399 LRCQ-----EREQQLRQDRDR------KFREEEQQLSRQERDRKFREEEQQVRRQERERK 1447
Query: 236 HSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNE-DVRSLGSVQLINNRCVDMQ----- 289
+ Q + + + F ++ +L+ Q L E D + L Q + + D +
Sbjct: 1448 FLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQE 1507
Query: 290 -RSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDE 329
RS+ ++K EEE+ R+Q ++ + E+ L R E
Sbjct: 1508 LRSQEPERKFLEEEQQLHRQQRQRK----FLQEEQQLRRQE 1544
Score = 41.6 bits (96), Expect = 0.003
Identities = 58/228 (25%), Positives = 97/228 (42%), Gaps = 34/228 (14%)
Query: 119 QKKEERDLVNRLKAEQARRK---QREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSR 175
QK E+ RLK EQ R+ +REE + +H + + + QEEE RE L+L
Sbjct: 436 QKHEQERREQRLKREQEERRDWLKREEETE--RHEQERRKQQLKRDQEEERRERWLKLEE 493
Query: 176 EMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRT 235
E ER EQ E E++L E +E ++ E+E+ L++ R+
Sbjct: 494 E--------ERREQQERREQQL---RREQEERREQRLKRQEEEERLQQR--------LRS 534
Query: 236 HSQLAQFVHEVKKSPFGK--DVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRH 293
QL + E ++ + + RL Q L ++ R QL+ + +R +
Sbjct: 535 EQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEER---RDQLLKR---EEERRQQ 588
Query: 294 EKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLL 341
K+ EE +R ++E+ + L R+E E + +QLL
Sbjct: 589 RLKREQEERLEQRLKREEVERLEQEERREQRLKREE--PEEERRQQLL 634
Score = 40.8 bits (94), Expect = 0.006
Identities = 39/182 (21%), Positives = 85/182 (46%), Gaps = 6/182 (3%)
Query: 131 KAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERPEQL 190
+ +Q RR+Q+ R QQL+ QL+ ++LR+E+EE + + +E E + E+ E+
Sbjct: 397 REQQLRREQQLRREQQLRREQQLR-REQQLRREQEEERHEQKHEQERREQRLKREQEERR 455
Query: 191 ESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQLAQFVHEVKKSP 250
+ + E E E E+++ + D+++ E K+ R Q + ++
Sbjct: 456 DWLKRE---EETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQE 512
Query: 251 FGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKGAEEEKPKRRRQE 310
++ RL + L + +RS ++ + R E+K+ +E + +R ++E
Sbjct: 513 ERREQRLKRQEEEERL--QQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKRE 570
Query: 311 KQ 312
++
Sbjct: 571 QE 572
Score = 40.8 bits (94), Expect = 0.006
Identities = 55/218 (25%), Positives = 88/218 (40%), Gaps = 33/218 (15%)
Query: 63 RDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKE 122
++ E+K REEE ET L ++ L RP E + +++
Sbjct: 1719 QELERKFREEEQLRQETEQEQLRRQERYRKILEEE------QLRPEREEQQL-----RRQ 1767
Query: 123 ERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE-------RENLLRLSR 175
ERD + + E+ R++REE+ + Q + ++LRQE EE R+ R
Sbjct: 1768 ERD--RKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEE 1825
Query: 176 EMLETGPEAERPEQLES----GEEELVLAEYESDEEKKVASGVD-----EDEDDLEEEHI 226
E L+ + +R Q EE+ E EE+++ + E E L EEHI
Sbjct: 1826 EQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHI 1885
Query: 227 TKIYHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQ 264
+ + H Q V E+K RL+ G+ Q
Sbjct: 1886 RRQQKEEQRHRQ----VGEIKSQEGKGHGRLLEPGTHQ 1919
Score = 40.0 bits (92), Expect = 0.010
Identities = 53/254 (20%), Positives = 108/254 (42%), Gaps = 25/254 (9%)
Query: 63 RDFEQKKREEEARLLETGTGPLHDEKDESLC----LSSSCEGAAGT-PRPAGEPAWVTQF 117
R+ EQ ++EEE L E E++ L E G P ++
Sbjct: 931 REEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY 990
Query: 118 VQKKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREM 177
+++E + +L E+ +++R+E +Q + + +L+ ++L +EE E+ L R+
Sbjct: 991 REEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQY 1050
Query: 178 LETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDED-DLEEEHITKIYHCSRTH 236
E E+L+ EE+L+ E E+ +++ ++E+ EEE + + R
Sbjct: 1051 RE-------EEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRR 1103
Query: 237 SQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKK 296
+ + E ++ L + + E+ R Q + + + + + E++
Sbjct: 1104 QERERQCREEEE-----------LQQEEEQLLREE-REKRRRQELERQYREEEEVQQEEE 1151
Query: 297 KGAEEEKPKRRRQE 310
+ EE KRRRQE
Sbjct: 1152 QLLREEPEKRRRQE 1165
Score = 38.5 bits (88), Expect = 0.029
Identities = 46/231 (19%), Positives = 96/231 (41%), Gaps = 17/231 (7%)
Query: 120 KKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLE 179
+++ RD R + E+ R+++R + + QL+ + L++EEEE + R R E
Sbjct: 866 QEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQE 925
Query: 180 TGPEAERPEQLESGEEELVLAEYES--DEEKKVASGVDEDEDDLEEEHITKIYHCSRTHS 237
+ EQL+ EE+L+ E E +E++ D+ EE+ + + R
Sbjct: 926 QERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQE 985
Query: 238 QLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKK 297
+ ++ E + + + R+ R +Q E+++
Sbjct: 986 REKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQ-------------QEEEQ 1032
Query: 298 GAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEAR 348
EE+ KRR QE++ + E++ ++ L E ++ + L ++ R
Sbjct: 1033 LLREEREKRRLQERER--QYREEEELQQEEEQLLGEERETRRRQELERQYR 1081
Score = 36.6 bits (83), Expect = 0.11
Identities = 49/222 (22%), Positives = 90/222 (40%), Gaps = 29/222 (13%)
Query: 119 QKKEERDLVNRLKAEQARRKQRE-----------ERLQQLQHRVQLKYAAKRLRQEEEER 167
Q++E+R L + EQ RR++RE E+LQ+ + QL+ L++++E R
Sbjct: 804 QQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERR 863
Query: 168 ENLLRLSREMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHIT 227
+ + + E ER + + + L E E++ + E+E++L+ E
Sbjct: 864 RSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQL----LQEEEEELQREERE 919
Query: 228 KIYHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVD 287
K R Q Q+ E ++ + R+ E R + + +
Sbjct: 920 K----RRRQEQERQYREE---EQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQ 972
Query: 288 MQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDE 329
+ EK++ E EK R +E Q E+ LLR+E
Sbjct: 973 LLGEEPEKRRRQEREKKYREEEELQ-------QEEEQLLREE 1007
Score = 36.6 bits (83), Expect = 0.11
Identities = 43/214 (20%), Positives = 94/214 (43%), Gaps = 28/214 (13%)
Query: 116 QFVQKKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSR 175
Q+ +++E + +L E+ +++R+E +Q + +L+ ++L +EE+E+ R +
Sbjct: 1139 QYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQ 1198
Query: 176 EMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRT 235
E + ++ +Q E++ +++ + EK+ A K+Y R
Sbjct: 1199 YREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENA------------VRDNKVYCKGRE 1246
Query: 236 HSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEK 295
+ Q Q +D +L S+Q D++ L Q +R + +R +
Sbjct: 1247 NEQFRQL----------EDSQLRDRQSQQ------DLQHLLGEQQERDREQERRRWQQRD 1290
Query: 296 KKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDE 329
+ EEE+ +R Q++ + E+ LLR+E
Sbjct: 1291 RHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREE 1324
Score = 33.5 bits (75), Expect = 0.92
Identities = 49/212 (23%), Positives = 84/212 (39%), Gaps = 43/212 (20%)
Query: 131 KAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERPEQ- 189
+ EQ K+R+ + Q+ + ++ + KR RQE + + R ++L+ ER EQ
Sbjct: 1301 REEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRK---FREEEQLLQ-----EREEQP 1352
Query: 190 LESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQLAQFVHEVKKS 249
L E + E E +++ ++E++ +E K
Sbjct: 1353 LRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKF-------------------- 1392
Query: 250 PFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKGAEEEKPKRRRQ 309
L Q L E + L + R + Q SR E+ + EE+ + RRQ
Sbjct: 1393 ----------LKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQ 1442
Query: 310 EKQAACPFYNHEQMGLLRDEALAEVKDMEQLL 341
E++ F EQ LR E + ++ EQLL
Sbjct: 1443 ERER--KFLEEEQQ--LRQERHRKFREEEQLL 1470
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 49.7 bits (117), Expect = 1e-05
Identities = 72/284 (25%), Positives = 119/284 (41%), Gaps = 35/284 (12%)
Query: 71 EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 124
EEE R+ LE + E L + E A R A E A + + VQ + +R
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1510
Query: 125 -----DLVNRLKAEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEERENLLRLSREML 178
+L +R+KAE ++++ LQ L+ R+Q + A +RLRQ E ER ++++ E
Sbjct: 1511 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1570
Query: 179 ETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQ 238
+ EAE + S E+ + E L+EEH+ + +
Sbjct: 1571 QRSAEAELQSKRASFAEKTA-----------------QLERSLQEEHVA-VAQLREEAER 1612
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKG 298
AQ E +++ + L R L NE +R + + + Q ++K+
Sbjct: 1613 RAQQQAEAERAREEAEREL----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1668
Query: 299 AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLA 342
AE E +R + E+QA EQ L + LAE ++L A
Sbjct: 1669 AEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAA 1711
Score = 46.2 bits (108), Expect = 1e-04
Identities = 80/378 (21%), Positives = 159/378 (42%), Gaps = 44/378 (11%)
Query: 68 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 127
+ ++ R L+ + +E+ LS + + AA + A E + + +K ++ +
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316
Query: 128 NRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERP 187
++ E R K E LQQ + Q + A+RL++++E+ L + + EAER
Sbjct: 2317 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373
Query: 188 EQLESGEE---------ELVLAEYESDEE----KKVASGVDEDEDDLE---EEHITKI-- 229
QLE E E+ A+ ++E+ +K A + E E +E +T +
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433
Query: 230 ---------YHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQL 280
+ R +A+ E +K ++ +L+ L S + V ++ + L Q
Sbjct: 2434 LEIQRQQSDHDAERLREAIAEL--EREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQA 2490
Query: 281 INNRCVDMQRSRHEKKKGAEEEKPKRRR--QEKQAACPFYNHEQMGLLRDEALAEVKDME 338
+ + + S ++++ E+EK K + Q++ A EQ R + E ++ +
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQME-QERQ 2546
Query: 339 QLLALGKEARACPYYGSR-LAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHN 397
+L+A +EAR + + +L L Q RL++Q+ +++E H
Sbjct: 2547 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2606
Query: 398 LIDTTTSMHSVEVSGSQL 415
HS EV+ SQ+
Sbjct: 2607 ----AALAHSEEVTASQV 2620
Score = 39.7 bits (91), Expect = 0.013
Identities = 49/210 (23%), Positives = 86/210 (40%), Gaps = 17/210 (8%)
Query: 120 KKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML- 178
K EE+ + R AEQ KQR+ Q R+ + RLR E E+ E +L E L
Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1737
Query: 179 ----ETGPEAERPEQLES------GEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITK 228
E ++ ++LE+ E E++LA EE+ S ++ + LE E +
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES-RSTSEKSKQRLEAE-AGR 1795
Query: 229 IYHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRC--- 285
+ ++L E K+ + + + E + ++G +
Sbjct: 1796 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855
Query: 286 -VDMQRSRHEKKKGAEEEKPKRRRQEKQAA 314
+ + ++ AE+E +RRR E+QAA
Sbjct: 1856 LKEKEAENERLRRLAEDEAFQRRRLEEQAA 1885
Score = 36.6 bits (83), Expect = 0.11
Identities = 38/147 (25%), Positives = 68/147 (46%), Gaps = 12/147 (8%)
Query: 72 EEARL-LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVNRL 130
EEAR+ E + +E+ L S E A A A + ++K+ E++ R
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKLRKEAEQEAARRA 2150
Query: 131 KAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERPEQL 190
+AEQA +Q++ +++ K+A + LRQ+ + + L L ++ ET Q
Sbjct: 2151 QAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELTTLRLQLEET------DHQK 2202
Query: 191 ESGEEELVLAEYESDEEKKVASGVDED 217
+EEL + E+ E + S V+E+
Sbjct: 2203 NLLDEELQRLKAEATEAARQRSQVEEE 2229
Score = 36.2 bits (82), Expect = 0.14
Identities = 57/249 (22%), Positives = 104/249 (41%), Gaps = 30/249 (12%)
Query: 109 GEPAWVTQFVQKKEERDLVNRLKAEQARRKQRE-ERL-----QQLQHRVQLKYAAKRLRQ 162
GE + ++ EE + +A Q+RR+ E ERL +Q Q R Q + AA++LR+
Sbjct: 2081 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2140
Query: 163 EEEERENLLRLSREMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLE 222
E E+ A R + ++ + A+ E ++ KK A + +E
Sbjct: 2141 EAEQE---------------AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185
Query: 223 EEHITKIYHCSRTHSQLAQFVHEVK--KSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQL 280
+E T T Q E++ K+ + R S + V + L ++
Sbjct: 2186 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2245
Query: 281 ---INNRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDM 337
NR + + R + ++ +EE K ++ ++AA ++ LR LAE +D+
Sbjct: 2246 RIEAENRAL-ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ--LAE-EDL 2301
Query: 338 EQLLALGKE 346
Q AL ++
Sbjct: 2302 AQQRALAEK 2310
Score = 35.8 bits (81), Expect = 0.19
Identities = 43/172 (25%), Positives = 72/172 (41%), Gaps = 24/172 (13%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
EQ++ EE RL E EK L + + A R A E +Q++ + +
Sbjct: 1352 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1400
Query: 126 LVNRLKAE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEERENLLR 172
+V R +A Q +++ +E LQQL+ + + AK RLR EEE R L+
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460
Query: 173 LSREMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEE 224
L + G + L + EE + ++ EE + +DE + +
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1512
Score = 33.9 bits (76), Expect = 0.70
Identities = 47/194 (24%), Positives = 83/194 (42%), Gaps = 25/194 (12%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 122
E++K ++EA+LL+ + + + E L + + ++ Q K E
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2517
Query: 123 ERDLVNRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETG 181
+ KA+Q R +Q R+++ Q Q R +L + + R+ + E E +R +E
Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2571
Query: 182 PEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSR-THSQLA 240
E ++ EQ +EEL+ E + + E LEE+H + H T SQ+A
Sbjct: 2572 -ELQQLEQQRRQQEELLAEENQR---------LREQLQLLEEQHRAALAHSEEVTASQVA 2621
Query: 241 QFVHEVKKSPFGKD 254
K P G+D
Sbjct: 2622 ----ATKTLPNGRD 2631
Score = 32.3 bits (72), Expect = 2.1
Identities = 72/389 (18%), Positives = 143/389 (36%), Gaps = 44/389 (11%)
Query: 59 LSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFV 118
L+ LR + E + L+E ++E L L +S E AA AG+
Sbjct: 1895 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA-----AGKA------- 1942
Query: 119 QKKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
L+ E R + E + + + +L+ A +R EEER R
Sbjct: 1943 ----------ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1992
Query: 179 ETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQ 238
E E Q ++ EE+ + + +E +++ + E+E ++ +
Sbjct: 1993 SLAAEEEAARQRKAALEEVERLKAKVEEARRL-------RERAEQESARQLQLAQEAAQK 2045
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKG 298
Q + + + + +Q V + +R G + + + +R +
Sbjct: 2046 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR--GEAEAARRAAEEAEEARVQ---- 2099
Query: 299 AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLA 358
AE E + RRQ ++A + E+ R +A A + + + RA +
Sbjct: 2100 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2159
Query: 359 IPAAQLVVLPYQMLLHAATRQAAGIR-----LQDQVVIIDEAHNLIDTTTSMHSVEVSGS 413
AA + ++ RQ A + L+ Q+ D NL+D + ++ +
Sbjct: 2160 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAEAT 2217
Query: 414 QLCQAHSQLLQYMERYGKRLKAKNLMYLK 442
+ + SQ+ + E + R++ + L LK
Sbjct: 2218 EAARQRSQVEE--ELFSVRVQMEELSKLK 2244
Score = 30.8 bits (68), Expect = 6.0
Identities = 26/109 (23%), Positives = 47/109 (43%), Gaps = 5/109 (4%)
Query: 121 KEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
+EE L + +AE+ R E + Q ++ +A + + E E +E R+ E++
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404
Query: 181 GPEA-ERPEQLESGEEELVLAEYESDEE----KKVASGVDEDEDDLEEE 224
A + +Q S +EEL S+ E + A + +EEE
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1453
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 49.7 bits (117), Expect = 1e-05
Identities = 72/284 (25%), Positives = 119/284 (41%), Gaps = 35/284 (12%)
Query: 71 EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 124
EEE R+ LE + E L + E A R A E A + + VQ + +R
Sbjct: 1455 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1514
Query: 125 -----DLVNRLKAEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEERENLLRLSREML 178
+L +R+KAE ++++ LQ L+ R+Q + A +RLRQ E ER ++++ E
Sbjct: 1515 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1574
Query: 179 ETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQ 238
+ EAE + S E+ + E L+EEH+ + +
Sbjct: 1575 QRSAEAELQSKRASFAEKTA-----------------QLERSLQEEHVA-VAQLREEAER 1616
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKG 298
AQ E +++ + L R L NE +R + + + Q ++K+
Sbjct: 1617 RAQQQAEAERAREEAEREL----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1672
Query: 299 AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLA 342
AE E +R + E+QA EQ L + LAE ++L A
Sbjct: 1673 AEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAA 1715
Score = 46.2 bits (108), Expect = 1e-04
Identities = 80/378 (21%), Positives = 159/378 (42%), Gaps = 44/378 (11%)
Query: 68 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 127
+ ++ R L+ + +E+ LS + + AA + A E + + +K ++ +
Sbjct: 2261 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2320
Query: 128 NRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERP 187
++ E R K E LQQ + Q + A+RL++++E+ L + + EAER
Sbjct: 2321 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2377
Query: 188 EQLESGEE---------ELVLAEYESDEE----KKVASGVDEDEDDLE---EEHITKI-- 229
QLE E E+ A+ ++E+ +K A + E E +E +T +
Sbjct: 2378 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2437
Query: 230 ---------YHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQL 280
+ R +A+ E +K ++ +L+ L S + V ++ + L Q
Sbjct: 2438 LEIQRQQSDHDAERLREAIAEL--EREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQA 2494
Query: 281 INNRCVDMQRSRHEKKKGAEEEKPKRRR--QEKQAACPFYNHEQMGLLRDEALAEVKDME 338
+ + + S ++++ E+EK K + Q++ A EQ R + E ++ +
Sbjct: 2495 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQME-QERQ 2550
Query: 339 QLLALGKEARACPYYGSR-LAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHN 397
+L+A +EAR + + +L L Q RL++Q+ +++E H
Sbjct: 2551 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2610
Query: 398 LIDTTTSMHSVEVSGSQL 415
HS EV+ SQ+
Sbjct: 2611 ----AALAHSEEVTASQV 2624
Score = 39.7 bits (91), Expect = 0.013
Identities = 49/210 (23%), Positives = 86/210 (40%), Gaps = 17/210 (8%)
Query: 120 KKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML- 178
K EE+ + R AEQ KQR+ Q R+ + RLR E E+ E +L E L
Sbjct: 1682 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1741
Query: 179 ----ETGPEAERPEQLES------GEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITK 228
E ++ ++LE+ E E++LA EE+ S ++ + LE E +
Sbjct: 1742 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES-RSTSEKSKQRLEAE-AGR 1799
Query: 229 IYHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRC--- 285
+ ++L E K+ + + + E + ++G +
Sbjct: 1800 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1859
Query: 286 -VDMQRSRHEKKKGAEEEKPKRRRQEKQAA 314
+ + ++ AE+E +RRR E+QAA
Sbjct: 1860 LKEKEAENERLRRLAEDEAFQRRRLEEQAA 1889
Score = 36.6 bits (83), Expect = 0.11
Identities = 38/147 (25%), Positives = 68/147 (46%), Gaps = 12/147 (8%)
Query: 72 EEARL-LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVNRL 130
EEAR+ E + +E+ L S E A A A + ++K+ E++ R
Sbjct: 2098 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKLRKEAEQEAARRA 2154
Query: 131 KAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERPEQL 190
+AEQA +Q++ +++ K+A + LRQ+ + + L L ++ ET Q
Sbjct: 2155 QAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELTTLRLQLEET------DHQK 2206
Query: 191 ESGEEELVLAEYESDEEKKVASGVDED 217
+EEL + E+ E + S V+E+
Sbjct: 2207 NLLDEELQRLKAEATEAARQRSQVEEE 2233
Score = 36.2 bits (82), Expect = 0.14
Identities = 57/249 (22%), Positives = 104/249 (41%), Gaps = 30/249 (12%)
Query: 109 GEPAWVTQFVQKKEERDLVNRLKAEQARRKQRE-ERL-----QQLQHRVQLKYAAKRLRQ 162
GE + ++ EE + +A Q+RR+ E ERL +Q Q R Q + AA++LR+
Sbjct: 2085 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2144
Query: 163 EEEERENLLRLSREMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLE 222
E E+ A R + ++ + A+ E ++ KK A + +E
Sbjct: 2145 EAEQE---------------AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2189
Query: 223 EEHITKIYHCSRTHSQLAQFVHEVK--KSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQL 280
+E T T Q E++ K+ + R S + V + L ++
Sbjct: 2190 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2249
Query: 281 ---INNRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDM 337
NR + + R + ++ +EE K ++ ++AA ++ LR LAE +D+
Sbjct: 2250 RIEAENRAL-ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ--LAE-EDL 2305
Query: 338 EQLLALGKE 346
Q AL ++
Sbjct: 2306 AQQRALAEK 2314
Score = 35.8 bits (81), Expect = 0.19
Identities = 43/172 (25%), Positives = 72/172 (41%), Gaps = 24/172 (13%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
EQ++ EE RL E EK L + + A R A E +Q++ + +
Sbjct: 1356 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1404
Query: 126 LVNRLKAE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEERENLLR 172
+V R +A Q +++ +E LQQL+ + + AK RLR EEE R L+
Sbjct: 1405 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1464
Query: 173 LSREMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEE 224
L + G + L + EE + ++ EE + +DE + +
Sbjct: 1465 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1516
Score = 33.9 bits (76), Expect = 0.70
Identities = 47/194 (24%), Positives = 83/194 (42%), Gaps = 25/194 (12%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 122
E++K ++EA+LL+ + + + E L + + ++ Q K E
Sbjct: 2462 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2521
Query: 123 ERDLVNRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETG 181
+ KA+Q R +Q R+++ Q Q R +L + + R+ + E E +R +E
Sbjct: 2522 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2575
Query: 182 PEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSR-THSQLA 240
E ++ EQ +EEL+ E + + E LEE+H + H T SQ+A
Sbjct: 2576 -ELQQLEQQRRQQEELLAEENQR---------LREQLQLLEEQHRAALAHSEEVTASQVA 2625
Query: 241 QFVHEVKKSPFGKD 254
K P G+D
Sbjct: 2626 ----ATKTLPNGRD 2635
Score = 32.3 bits (72), Expect = 2.1
Identities = 72/389 (18%), Positives = 143/389 (36%), Gaps = 44/389 (11%)
Query: 59 LSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFV 118
L+ LR + E + L+E ++E L L +S E AA AG+
Sbjct: 1899 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA-----AGKA------- 1946
Query: 119 QKKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
L+ E R + E + + + +L+ A +R EEER R
Sbjct: 1947 ----------ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1996
Query: 179 ETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQ 238
E E Q ++ EE+ + + +E +++ + E+E ++ +
Sbjct: 1997 SLAAEEEAARQRKAALEEVERLKAKVEEARRL-------RERAEQESARQLQLAQEAAQK 2049
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKG 298
Q + + + + +Q V + +R G + + + +R +
Sbjct: 2050 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR--GEAEAARRAAEEAEEARVQ---- 2103
Query: 299 AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLA 358
AE E + RRQ ++A + E+ R +A A + + + RA +
Sbjct: 2104 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2163
Query: 359 IPAAQLVVLPYQMLLHAATRQAAGIR-----LQDQVVIIDEAHNLIDTTTSMHSVEVSGS 413
AA + ++ RQ A + L+ Q+ D NL+D + ++ +
Sbjct: 2164 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAEAT 2221
Query: 414 QLCQAHSQLLQYMERYGKRLKAKNLMYLK 442
+ + SQ+ + E + R++ + L LK
Sbjct: 2222 EAARQRSQVEE--ELFSVRVQMEELSKLK 2248
Score = 30.8 bits (68), Expect = 6.0
Identities = 26/109 (23%), Positives = 47/109 (43%), Gaps = 5/109 (4%)
Query: 121 KEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
+EE L + +AE+ R E + Q ++ +A + + E E +E R+ E++
Sbjct: 1349 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1408
Query: 181 GPEA-ERPEQLESGEEELVLAEYESDEE----KKVASGVDEDEDDLEEE 224
A + +Q S +EEL S+ E + A + +EEE
Sbjct: 1409 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1457
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 49.7 bits (117), Expect = 1e-05
Identities = 72/284 (25%), Positives = 119/284 (41%), Gaps = 35/284 (12%)
Query: 71 EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 124
EEE R+ LE + E L + E A R A E A + + VQ + +R
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1510
Query: 125 -----DLVNRLKAEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEERENLLRLSREML 178
+L +R+KAE ++++ LQ L+ R+Q + A +RLRQ E ER ++++ E
Sbjct: 1511 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1570
Query: 179 ETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQ 238
+ EAE + S E+ + E L+EEH+ + +
Sbjct: 1571 QRSAEAELQSKRASFAEKTA-----------------QLERSLQEEHVA-VAQLREEAER 1612
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKG 298
AQ E +++ + L R L NE +R + + + Q ++K+
Sbjct: 1613 RAQQQAEAERAREEAEREL----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1668
Query: 299 AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLA 342
AE E +R + E+QA EQ L + LAE ++L A
Sbjct: 1669 AEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAA 1711
Score = 46.2 bits (108), Expect = 1e-04
Identities = 80/378 (21%), Positives = 159/378 (42%), Gaps = 44/378 (11%)
Query: 68 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 127
+ ++ R L+ + +E+ LS + + AA + A E + + +K ++ +
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316
Query: 128 NRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERP 187
++ E R K E LQQ + Q + A+RL++++E+ L + + EAER
Sbjct: 2317 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373
Query: 188 EQLESGEE---------ELVLAEYESDEE----KKVASGVDEDEDDLE---EEHITKI-- 229
QLE E E+ A+ ++E+ +K A + E E +E +T +
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433
Query: 230 ---------YHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQL 280
+ R +A+ E +K ++ +L+ L S + V ++ + L Q
Sbjct: 2434 LEIQRQQSDHDAERLREAIAEL--EREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQA 2490
Query: 281 INNRCVDMQRSRHEKKKGAEEEKPKRRR--QEKQAACPFYNHEQMGLLRDEALAEVKDME 338
+ + + S ++++ E+EK K + Q++ A EQ R + E ++ +
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQME-QERQ 2546
Query: 339 QLLALGKEARACPYYGSR-LAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHN 397
+L+A +EAR + + +L L Q RL++Q+ +++E H
Sbjct: 2547 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2606
Query: 398 LIDTTTSMHSVEVSGSQL 415
HS EV+ SQ+
Sbjct: 2607 ----AALAHSEEVTASQV 2620
Score = 39.7 bits (91), Expect = 0.013
Identities = 49/210 (23%), Positives = 86/210 (40%), Gaps = 17/210 (8%)
Query: 120 KKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML- 178
K EE+ + R AEQ KQR+ Q R+ + RLR E E+ E +L E L
Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1737
Query: 179 ----ETGPEAERPEQLES------GEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITK 228
E ++ ++LE+ E E++LA EE+ S ++ + LE E +
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES-RSTSEKSKQRLEAE-AGR 1795
Query: 229 IYHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRC--- 285
+ ++L E K+ + + + E + ++G +
Sbjct: 1796 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855
Query: 286 -VDMQRSRHEKKKGAEEEKPKRRRQEKQAA 314
+ + ++ AE+E +RRR E+QAA
Sbjct: 1856 LKEKEAENERLRRLAEDEAFQRRRLEEQAA 1885
Score = 36.6 bits (83), Expect = 0.11
Identities = 38/147 (25%), Positives = 68/147 (46%), Gaps = 12/147 (8%)
Query: 72 EEARL-LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVNRL 130
EEAR+ E + +E+ L S E A A A + ++K+ E++ R
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKLRKEAEQEAARRA 2150
Query: 131 KAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERPEQL 190
+AEQA +Q++ +++ K+A + LRQ+ + + L L ++ ET Q
Sbjct: 2151 QAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELTTLRLQLEET------DHQK 2202
Query: 191 ESGEEELVLAEYESDEEKKVASGVDED 217
+EEL + E+ E + S V+E+
Sbjct: 2203 NLLDEELQRLKAEATEAARQRSQVEEE 2229
Score = 36.2 bits (82), Expect = 0.14
Identities = 57/249 (22%), Positives = 104/249 (41%), Gaps = 30/249 (12%)
Query: 109 GEPAWVTQFVQKKEERDLVNRLKAEQARRKQRE-ERL-----QQLQHRVQLKYAAKRLRQ 162
GE + ++ EE + +A Q+RR+ E ERL +Q Q R Q + AA++LR+
Sbjct: 2081 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2140
Query: 163 EEEERENLLRLSREMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLE 222
E E+ A R + ++ + A+ E ++ KK A + +E
Sbjct: 2141 EAEQE---------------AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185
Query: 223 EEHITKIYHCSRTHSQLAQFVHEVK--KSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQL 280
+E T T Q E++ K+ + R S + V + L ++
Sbjct: 2186 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2245
Query: 281 ---INNRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDM 337
NR + + R + ++ +EE K ++ ++AA ++ LR LAE +D+
Sbjct: 2246 RIEAENRAL-ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ--LAE-EDL 2301
Query: 338 EQLLALGKE 346
Q AL ++
Sbjct: 2302 AQQRALAEK 2310
Score = 35.8 bits (81), Expect = 0.19
Identities = 43/172 (25%), Positives = 72/172 (41%), Gaps = 24/172 (13%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
EQ++ EE RL E EK L + + A R A E +Q++ + +
Sbjct: 1352 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1400
Query: 126 LVNRLKAE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEERENLLR 172
+V R +A Q +++ +E LQQL+ + + AK RLR EEE R L+
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460
Query: 173 LSREMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEE 224
L + G + L + EE + ++ EE + +DE + +
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1512
Score = 33.9 bits (76), Expect = 0.70
Identities = 47/194 (24%), Positives = 83/194 (42%), Gaps = 25/194 (12%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 122
E++K ++EA+LL+ + + + E L + + ++ Q K E
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2517
Query: 123 ERDLVNRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETG 181
+ KA+Q R +Q R+++ Q Q R +L + + R+ + E E +R +E
Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2571
Query: 182 PEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSR-THSQLA 240
E ++ EQ +EEL+ E + + E LEE+H + H T SQ+A
Sbjct: 2572 -ELQQLEQQRRQQEELLAEENQR---------LREQLQLLEEQHRAALAHSEEVTASQVA 2621
Query: 241 QFVHEVKKSPFGKD 254
K P G+D
Sbjct: 2622 ----ATKTLPNGRD 2631
Score = 32.3 bits (72), Expect = 2.1
Identities = 72/389 (18%), Positives = 143/389 (36%), Gaps = 44/389 (11%)
Query: 59 LSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFV 118
L+ LR + E + L+E ++E L L +S E AA AG+
Sbjct: 1895 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA-----AGKA------- 1942
Query: 119 QKKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
L+ E R + E + + + +L+ A +R EEER R
Sbjct: 1943 ----------ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1992
Query: 179 ETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQ 238
E E Q ++ EE+ + + +E +++ + E+E ++ +
Sbjct: 1993 SLAAEEEAARQRKAALEEVERLKAKVEEARRL-------RERAEQESARQLQLAQEAAQK 2045
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKG 298
Q + + + + +Q V + +R G + + + +R +
Sbjct: 2046 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR--GEAEAARRAAEEAEEARVQ---- 2099
Query: 299 AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLA 358
AE E + RRQ ++A + E+ R +A A + + + RA +
Sbjct: 2100 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2159
Query: 359 IPAAQLVVLPYQMLLHAATRQAAGIR-----LQDQVVIIDEAHNLIDTTTSMHSVEVSGS 413
AA + ++ RQ A + L+ Q+ D NL+D + ++ +
Sbjct: 2160 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAEAT 2217
Query: 414 QLCQAHSQLLQYMERYGKRLKAKNLMYLK 442
+ + SQ+ + E + R++ + L LK
Sbjct: 2218 EAARQRSQVEE--ELFSVRVQMEELSKLK 2244
Score = 30.8 bits (68), Expect = 6.0
Identities = 26/109 (23%), Positives = 47/109 (43%), Gaps = 5/109 (4%)
Query: 121 KEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
+EE L + +AE+ R E + Q ++ +A + + E E +E R+ E++
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404
Query: 181 GPEA-ERPEQLESGEEELVLAEYESDEE----KKVASGVDEDEDDLEEE 224
A + +Q S +EEL S+ E + A + +EEE
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1453
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 49.7 bits (117), Expect = 1e-05
Identities = 72/284 (25%), Positives = 119/284 (41%), Gaps = 35/284 (12%)
Query: 71 EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 124
EEE R+ LE + E L + E A R A E A + + VQ + +R
Sbjct: 1419 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1478
Query: 125 -----DLVNRLKAEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEERENLLRLSREML 178
+L +R+KAE ++++ LQ L+ R+Q + A +RLRQ E ER ++++ E
Sbjct: 1479 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1538
Query: 179 ETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQ 238
+ EAE + S E+ + E L+EEH+ + +
Sbjct: 1539 QRSAEAELQSKRASFAEKTA-----------------QLERSLQEEHVA-VAQLREEAER 1580
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKG 298
AQ E +++ + L R L NE +R + + + Q ++K+
Sbjct: 1581 RAQQQAEAERAREEAEREL----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1636
Query: 299 AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLA 342
AE E +R + E+QA EQ L + LAE ++L A
Sbjct: 1637 AEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAA 1679
Score = 46.2 bits (108), Expect = 1e-04
Identities = 80/378 (21%), Positives = 159/378 (42%), Gaps = 44/378 (11%)
Query: 68 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 127
+ ++ R L+ + +E+ LS + + AA + A E + + +K ++ +
Sbjct: 2225 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2284
Query: 128 NRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERP 187
++ E R K E LQQ + Q + A+RL++++E+ L + + EAER
Sbjct: 2285 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2341
Query: 188 EQLESGEE---------ELVLAEYESDEE----KKVASGVDEDEDDLE---EEHITKI-- 229
QLE E E+ A+ ++E+ +K A + E E +E +T +
Sbjct: 2342 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2401
Query: 230 ---------YHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQL 280
+ R +A+ E +K ++ +L+ L S + V ++ + L Q
Sbjct: 2402 LEIQRQQSDHDAERLREAIAEL--EREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQA 2458
Query: 281 INNRCVDMQRSRHEKKKGAEEEKPKRRR--QEKQAACPFYNHEQMGLLRDEALAEVKDME 338
+ + + S ++++ E+EK K + Q++ A EQ R + E ++ +
Sbjct: 2459 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQME-QERQ 2514
Query: 339 QLLALGKEARACPYYGSR-LAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHN 397
+L+A +EAR + + +L L Q RL++Q+ +++E H
Sbjct: 2515 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2574
Query: 398 LIDTTTSMHSVEVSGSQL 415
HS EV+ SQ+
Sbjct: 2575 ----AALAHSEEVTASQV 2588
Score = 39.7 bits (91), Expect = 0.013
Identities = 49/210 (23%), Positives = 86/210 (40%), Gaps = 17/210 (8%)
Query: 120 KKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML- 178
K EE+ + R AEQ KQR+ Q R+ + RLR E E+ E +L E L
Sbjct: 1646 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1705
Query: 179 ----ETGPEAERPEQLES------GEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITK 228
E ++ ++LE+ E E++LA EE+ S ++ + LE E +
Sbjct: 1706 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES-RSTSEKSKQRLEAE-AGR 1763
Query: 229 IYHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRC--- 285
+ ++L E K+ + + + E + ++G +
Sbjct: 1764 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1823
Query: 286 -VDMQRSRHEKKKGAEEEKPKRRRQEKQAA 314
+ + ++ AE+E +RRR E+QAA
Sbjct: 1824 LKEKEAENERLRRLAEDEAFQRRRLEEQAA 1853
Score = 36.6 bits (83), Expect = 0.11
Identities = 38/147 (25%), Positives = 68/147 (46%), Gaps = 12/147 (8%)
Query: 72 EEARL-LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVNRL 130
EEAR+ E + +E+ L S E A A A + ++K+ E++ R
Sbjct: 2062 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKLRKEAEQEAARRA 2118
Query: 131 KAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERPEQL 190
+AEQA +Q++ +++ K+A + LRQ+ + + L L ++ ET Q
Sbjct: 2119 QAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELTTLRLQLEET------DHQK 2170
Query: 191 ESGEEELVLAEYESDEEKKVASGVDED 217
+EEL + E+ E + S V+E+
Sbjct: 2171 NLLDEELQRLKAEATEAARQRSQVEEE 2197
Score = 36.2 bits (82), Expect = 0.14
Identities = 57/249 (22%), Positives = 104/249 (41%), Gaps = 30/249 (12%)
Query: 109 GEPAWVTQFVQKKEERDLVNRLKAEQARRKQRE-ERL-----QQLQHRVQLKYAAKRLRQ 162
GE + ++ EE + +A Q+RR+ E ERL +Q Q R Q + AA++LR+
Sbjct: 2049 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2108
Query: 163 EEEERENLLRLSREMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLE 222
E E+ A R + ++ + A+ E ++ KK A + +E
Sbjct: 2109 EAEQE---------------AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2153
Query: 223 EEHITKIYHCSRTHSQLAQFVHEVK--KSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQL 280
+E T T Q E++ K+ + R S + V + L ++
Sbjct: 2154 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2213
Query: 281 ---INNRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDM 337
NR + + R + ++ +EE K ++ ++AA ++ LR LAE +D+
Sbjct: 2214 RIEAENRAL-ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ--LAE-EDL 2269
Query: 338 EQLLALGKE 346
Q AL ++
Sbjct: 2270 AQQRALAEK 2278
Score = 35.8 bits (81), Expect = 0.19
Identities = 43/172 (25%), Positives = 72/172 (41%), Gaps = 24/172 (13%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
EQ++ EE RL E EK L + + A R A E +Q++ + +
Sbjct: 1320 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1368
Query: 126 LVNRLKAE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEERENLLR 172
+V R +A Q +++ +E LQQL+ + + AK RLR EEE R L+
Sbjct: 1369 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1428
Query: 173 LSREMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEE 224
L + G + L + EE + ++ EE + +DE + +
Sbjct: 1429 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1480
Score = 33.9 bits (76), Expect = 0.70
Identities = 47/194 (24%), Positives = 83/194 (42%), Gaps = 25/194 (12%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 122
E++K ++EA+LL+ + + + E L + + ++ Q K E
Sbjct: 2426 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2485
Query: 123 ERDLVNRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETG 181
+ KA+Q R +Q R+++ Q Q R +L + + R+ + E E +R +E
Sbjct: 2486 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2539
Query: 182 PEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSR-THSQLA 240
E ++ EQ +EEL+ E + + E LEE+H + H T SQ+A
Sbjct: 2540 -ELQQLEQQRRQQEELLAEENQR---------LREQLQLLEEQHRAALAHSEEVTASQVA 2589
Query: 241 QFVHEVKKSPFGKD 254
K P G+D
Sbjct: 2590 ----ATKTLPNGRD 2599
Score = 32.3 bits (72), Expect = 2.1
Identities = 72/389 (18%), Positives = 143/389 (36%), Gaps = 44/389 (11%)
Query: 59 LSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFV 118
L+ LR + E + L+E ++E L L +S E AA AG+
Sbjct: 1863 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA-----AGKA------- 1910
Query: 119 QKKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
L+ E R + E + + + +L+ A +R EEER R
Sbjct: 1911 ----------ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1960
Query: 179 ETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQ 238
E E Q ++ EE+ + + +E +++ + E+E ++ +
Sbjct: 1961 SLAAEEEAARQRKAALEEVERLKAKVEEARRL-------RERAEQESARQLQLAQEAAQK 2013
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKG 298
Q + + + + +Q V + +R G + + + +R +
Sbjct: 2014 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR--GEAEAARRAAEEAEEARVQ---- 2067
Query: 299 AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLA 358
AE E + RRQ ++A + E+ R +A A + + + RA +
Sbjct: 2068 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2127
Query: 359 IPAAQLVVLPYQMLLHAATRQAAGIR-----LQDQVVIIDEAHNLIDTTTSMHSVEVSGS 413
AA + ++ RQ A + L+ Q+ D NL+D + ++ +
Sbjct: 2128 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAEAT 2185
Query: 414 QLCQAHSQLLQYMERYGKRLKAKNLMYLK 442
+ + SQ+ + E + R++ + L LK
Sbjct: 2186 EAARQRSQVEE--ELFSVRVQMEELSKLK 2212
Score = 30.8 bits (68), Expect = 6.0
Identities = 26/109 (23%), Positives = 47/109 (43%), Gaps = 5/109 (4%)
Query: 121 KEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
+EE L + +AE+ R E + Q ++ +A + + E E +E R+ E++
Sbjct: 1313 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1372
Query: 181 GPEA-ERPEQLESGEEELVLAEYESDEE----KKVASGVDEDEDDLEEE 224
A + +Q S +EEL S+ E + A + +EEE
Sbjct: 1373 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1421
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 49.7 bits (117), Expect = 1e-05
Identities = 72/284 (25%), Positives = 119/284 (41%), Gaps = 35/284 (12%)
Query: 71 EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 124
EEE R+ LE + E L + E A R A E A + + VQ + +R
Sbjct: 1588 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1647
Query: 125 -----DLVNRLKAEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEERENLLRLSREML 178
+L +R+KAE ++++ LQ L+ R+Q + A +RLRQ E ER ++++ E
Sbjct: 1648 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1707
Query: 179 ETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQ 238
+ EAE + S E+ + E L+EEH+ + +
Sbjct: 1708 QRSAEAELQSKRASFAEKTA-----------------QLERSLQEEHVA-VAQLREEAER 1749
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKG 298
AQ E +++ + L R L NE +R + + + Q ++K+
Sbjct: 1750 RAQQQAEAERAREEAEREL----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1805
Query: 299 AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLA 342
AE E +R + E+QA EQ L + LAE ++L A
Sbjct: 1806 AEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAA 1848
Score = 46.2 bits (108), Expect = 1e-04
Identities = 80/378 (21%), Positives = 159/378 (42%), Gaps = 44/378 (11%)
Query: 68 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 127
+ ++ R L+ + +E+ LS + + AA + A E + + +K ++ +
Sbjct: 2394 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2453
Query: 128 NRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERP 187
++ E R K E LQQ + Q + A+RL++++E+ L + + EAER
Sbjct: 2454 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2510
Query: 188 EQLESGEE---------ELVLAEYESDEE----KKVASGVDEDEDDLE---EEHITKI-- 229
QLE E E+ A+ ++E+ +K A + E E +E +T +
Sbjct: 2511 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2570
Query: 230 ---------YHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQL 280
+ R +A+ E +K ++ +L+ L S + V ++ + L Q
Sbjct: 2571 LEIQRQQSDHDAERLREAIAEL--EREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQA 2627
Query: 281 INNRCVDMQRSRHEKKKGAEEEKPKRRR--QEKQAACPFYNHEQMGLLRDEALAEVKDME 338
+ + + S ++++ E+EK K + Q++ A EQ R + E ++ +
Sbjct: 2628 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQME-QERQ 2683
Query: 339 QLLALGKEARACPYYGSR-LAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHN 397
+L+A +EAR + + +L L Q RL++Q+ +++E H
Sbjct: 2684 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2743
Query: 398 LIDTTTSMHSVEVSGSQL 415
HS EV+ SQ+
Sbjct: 2744 ----AALAHSEEVTASQV 2757
Score = 39.7 bits (91), Expect = 0.013
Identities = 49/210 (23%), Positives = 86/210 (40%), Gaps = 17/210 (8%)
Query: 120 KKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML- 178
K EE+ + R AEQ KQR+ Q R+ + RLR E E+ E +L E L
Sbjct: 1815 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1874
Query: 179 ----ETGPEAERPEQLES------GEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITK 228
E ++ ++LE+ E E++LA EE+ S ++ + LE E +
Sbjct: 1875 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES-RSTSEKSKQRLEAE-AGR 1932
Query: 229 IYHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRC--- 285
+ ++L E K+ + + + E + ++G +
Sbjct: 1933 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1992
Query: 286 -VDMQRSRHEKKKGAEEEKPKRRRQEKQAA 314
+ + ++ AE+E +RRR E+QAA
Sbjct: 1993 LKEKEAENERLRRLAEDEAFQRRRLEEQAA 2022
Score = 36.6 bits (83), Expect = 0.11
Identities = 38/147 (25%), Positives = 68/147 (46%), Gaps = 12/147 (8%)
Query: 72 EEARL-LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVNRL 130
EEAR+ E + +E+ L S E A A A + ++K+ E++ R
Sbjct: 2231 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKLRKEAEQEAARRA 2287
Query: 131 KAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERPEQL 190
+AEQA +Q++ +++ K+A + LRQ+ + + L L ++ ET Q
Sbjct: 2288 QAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELTTLRLQLEET------DHQK 2339
Query: 191 ESGEEELVLAEYESDEEKKVASGVDED 217
+EEL + E+ E + S V+E+
Sbjct: 2340 NLLDEELQRLKAEATEAARQRSQVEEE 2366
Score = 36.2 bits (82), Expect = 0.14
Identities = 57/249 (22%), Positives = 104/249 (41%), Gaps = 30/249 (12%)
Query: 109 GEPAWVTQFVQKKEERDLVNRLKAEQARRKQRE-ERL-----QQLQHRVQLKYAAKRLRQ 162
GE + ++ EE + +A Q+RR+ E ERL +Q Q R Q + AA++LR+
Sbjct: 2218 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2277
Query: 163 EEEERENLLRLSREMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLE 222
E E+ A R + ++ + A+ E ++ KK A + +E
Sbjct: 2278 EAEQE---------------AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2322
Query: 223 EEHITKIYHCSRTHSQLAQFVHEVK--KSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQL 280
+E T T Q E++ K+ + R S + V + L ++
Sbjct: 2323 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2382
Query: 281 ---INNRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDM 337
NR + + R + ++ +EE K ++ ++AA ++ LR LAE +D+
Sbjct: 2383 RIEAENRAL-ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ--LAE-EDL 2438
Query: 338 EQLLALGKE 346
Q AL ++
Sbjct: 2439 AQQRALAEK 2447
Score = 35.8 bits (81), Expect = 0.19
Identities = 43/172 (25%), Positives = 72/172 (41%), Gaps = 24/172 (13%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
EQ++ EE RL E EK L + + A R A E +Q++ + +
Sbjct: 1489 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1537
Query: 126 LVNRLKAE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEERENLLR 172
+V R +A Q +++ +E LQQL+ + + AK RLR EEE R L+
Sbjct: 1538 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1597
Query: 173 LSREMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEE 224
L + G + L + EE + ++ EE + +DE + +
Sbjct: 1598 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1649
Score = 33.9 bits (76), Expect = 0.70
Identities = 47/194 (24%), Positives = 83/194 (42%), Gaps = 25/194 (12%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 122
E++K ++EA+LL+ + + + E L + + ++ Q K E
Sbjct: 2595 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2654
Query: 123 ERDLVNRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETG 181
+ KA+Q R +Q R+++ Q Q R +L + + R+ + E E +R +E
Sbjct: 2655 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2708
Query: 182 PEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSR-THSQLA 240
E ++ EQ +EEL+ E + + E LEE+H + H T SQ+A
Sbjct: 2709 -ELQQLEQQRRQQEELLAEENQR---------LREQLQLLEEQHRAALAHSEEVTASQVA 2758
Query: 241 QFVHEVKKSPFGKD 254
K P G+D
Sbjct: 2759 ----ATKTLPNGRD 2768
Score = 32.3 bits (72), Expect = 2.1
Identities = 72/389 (18%), Positives = 143/389 (36%), Gaps = 44/389 (11%)
Query: 59 LSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFV 118
L+ LR + E + L+E ++E L L +S E AA AG+
Sbjct: 2032 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA-----AGKA------- 2079
Query: 119 QKKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
L+ E R + E + + + +L+ A +R EEER R
Sbjct: 2080 ----------ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 2129
Query: 179 ETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQ 238
E E Q ++ EE+ + + +E +++ + E+E ++ +
Sbjct: 2130 SLAAEEEAARQRKAALEEVERLKAKVEEARRL-------RERAEQESARQLQLAQEAAQK 2182
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKG 298
Q + + + + +Q V + +R G + + + +R +
Sbjct: 2183 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR--GEAEAARRAAEEAEEARVQ---- 2236
Query: 299 AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLA 358
AE E + RRQ ++A + E+ R +A A + + + RA +
Sbjct: 2237 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2296
Query: 359 IPAAQLVVLPYQMLLHAATRQAAGIR-----LQDQVVIIDEAHNLIDTTTSMHSVEVSGS 413
AA + ++ RQ A + L+ Q+ D NL+D + ++ +
Sbjct: 2297 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAEAT 2354
Query: 414 QLCQAHSQLLQYMERYGKRLKAKNLMYLK 442
+ + SQ+ + E + R++ + L LK
Sbjct: 2355 EAARQRSQVEE--ELFSVRVQMEELSKLK 2381
Score = 30.8 bits (68), Expect = 6.0
Identities = 26/109 (23%), Positives = 47/109 (43%), Gaps = 5/109 (4%)
Query: 121 KEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
+EE L + +AE+ R E + Q ++ +A + + E E +E R+ E++
Sbjct: 1482 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1541
Query: 181 GPEA-ERPEQLESGEEELVLAEYESDEE----KKVASGVDEDEDDLEEE 224
A + +Q S +EEL S+ E + A + +EEE
Sbjct: 1542 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1590
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 49.7 bits (117), Expect = 1e-05
Identities = 72/284 (25%), Positives = 119/284 (41%), Gaps = 35/284 (12%)
Query: 71 EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 124
EEE R+ LE + E L + E A R A E A + + VQ + +R
Sbjct: 1429 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1488
Query: 125 -----DLVNRLKAEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEERENLLRLSREML 178
+L +R+KAE ++++ LQ L+ R+Q + A +RLRQ E ER ++++ E
Sbjct: 1489 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1548
Query: 179 ETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQ 238
+ EAE + S E+ + E L+EEH+ + +
Sbjct: 1549 QRSAEAELQSKRASFAEKTA-----------------QLERSLQEEHVA-VAQLREEAER 1590
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKG 298
AQ E +++ + L R L NE +R + + + Q ++K+
Sbjct: 1591 RAQQQAEAERAREEAEREL----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1646
Query: 299 AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLA 342
AE E +R + E+QA EQ L + LAE ++L A
Sbjct: 1647 AEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAA 1689
Score = 46.2 bits (108), Expect = 1e-04
Identities = 80/378 (21%), Positives = 159/378 (42%), Gaps = 44/378 (11%)
Query: 68 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 127
+ ++ R L+ + +E+ LS + + AA + A E + + +K ++ +
Sbjct: 2235 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2294
Query: 128 NRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERP 187
++ E R K E LQQ + Q + A+RL++++E+ L + + EAER
Sbjct: 2295 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2351
Query: 188 EQLESGEE---------ELVLAEYESDEE----KKVASGVDEDEDDLE---EEHITKI-- 229
QLE E E+ A+ ++E+ +K A + E E +E +T +
Sbjct: 2352 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2411
Query: 230 ---------YHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQL 280
+ R +A+ E +K ++ +L+ L S + V ++ + L Q
Sbjct: 2412 LEIQRQQSDHDAERLREAIAEL--EREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQA 2468
Query: 281 INNRCVDMQRSRHEKKKGAEEEKPKRRR--QEKQAACPFYNHEQMGLLRDEALAEVKDME 338
+ + + S ++++ E+EK K + Q++ A EQ R + E ++ +
Sbjct: 2469 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQME-QERQ 2524
Query: 339 QLLALGKEARACPYYGSR-LAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHN 397
+L+A +EAR + + +L L Q RL++Q+ +++E H
Sbjct: 2525 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2584
Query: 398 LIDTTTSMHSVEVSGSQL 415
HS EV+ SQ+
Sbjct: 2585 ----AALAHSEEVTASQV 2598
Score = 39.7 bits (91), Expect = 0.013
Identities = 49/210 (23%), Positives = 86/210 (40%), Gaps = 17/210 (8%)
Query: 120 KKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML- 178
K EE+ + R AEQ KQR+ Q R+ + RLR E E+ E +L E L
Sbjct: 1656 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1715
Query: 179 ----ETGPEAERPEQLES------GEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITK 228
E ++ ++LE+ E E++LA EE+ S ++ + LE E +
Sbjct: 1716 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES-RSTSEKSKQRLEAE-AGR 1773
Query: 229 IYHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRC--- 285
+ ++L E K+ + + + E + ++G +
Sbjct: 1774 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1833
Query: 286 -VDMQRSRHEKKKGAEEEKPKRRRQEKQAA 314
+ + ++ AE+E +RRR E+QAA
Sbjct: 1834 LKEKEAENERLRRLAEDEAFQRRRLEEQAA 1863
Score = 36.6 bits (83), Expect = 0.11
Identities = 38/147 (25%), Positives = 68/147 (46%), Gaps = 12/147 (8%)
Query: 72 EEARL-LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVNRL 130
EEAR+ E + +E+ L S E A A A + ++K+ E++ R
Sbjct: 2072 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKLRKEAEQEAARRA 2128
Query: 131 KAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERPEQL 190
+AEQA +Q++ +++ K+A + LRQ+ + + L L ++ ET Q
Sbjct: 2129 QAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELTTLRLQLEET------DHQK 2180
Query: 191 ESGEEELVLAEYESDEEKKVASGVDED 217
+EEL + E+ E + S V+E+
Sbjct: 2181 NLLDEELQRLKAEATEAARQRSQVEEE 2207
Score = 36.2 bits (82), Expect = 0.14
Identities = 57/249 (22%), Positives = 104/249 (41%), Gaps = 30/249 (12%)
Query: 109 GEPAWVTQFVQKKEERDLVNRLKAEQARRKQRE-ERL-----QQLQHRVQLKYAAKRLRQ 162
GE + ++ EE + +A Q+RR+ E ERL +Q Q R Q + AA++LR+
Sbjct: 2059 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2118
Query: 163 EEEERENLLRLSREMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLE 222
E E+ A R + ++ + A+ E ++ KK A + +E
Sbjct: 2119 EAEQE---------------AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2163
Query: 223 EEHITKIYHCSRTHSQLAQFVHEVK--KSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQL 280
+E T T Q E++ K+ + R S + V + L ++
Sbjct: 2164 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2223
Query: 281 ---INNRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDM 337
NR + + R + ++ +EE K ++ ++AA ++ LR LAE +D+
Sbjct: 2224 RIEAENRAL-ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ--LAE-EDL 2279
Query: 338 EQLLALGKE 346
Q AL ++
Sbjct: 2280 AQQRALAEK 2288
Score = 35.8 bits (81), Expect = 0.19
Identities = 43/172 (25%), Positives = 72/172 (41%), Gaps = 24/172 (13%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
EQ++ EE RL E EK L + + A R A E +Q++ + +
Sbjct: 1330 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1378
Query: 126 LVNRLKAE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEERENLLR 172
+V R +A Q +++ +E LQQL+ + + AK RLR EEE R L+
Sbjct: 1379 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1438
Query: 173 LSREMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEE 224
L + G + L + EE + ++ EE + +DE + +
Sbjct: 1439 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1490
Score = 33.9 bits (76), Expect = 0.70
Identities = 47/194 (24%), Positives = 83/194 (42%), Gaps = 25/194 (12%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 122
E++K ++EA+LL+ + + + E L + + ++ Q K E
Sbjct: 2436 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2495
Query: 123 ERDLVNRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETG 181
+ KA+Q R +Q R+++ Q Q R +L + + R+ + E E +R +E
Sbjct: 2496 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2549
Query: 182 PEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSR-THSQLA 240
E ++ EQ +EEL+ E + + E LEE+H + H T SQ+A
Sbjct: 2550 -ELQQLEQQRRQQEELLAEENQR---------LREQLQLLEEQHRAALAHSEEVTASQVA 2599
Query: 241 QFVHEVKKSPFGKD 254
K P G+D
Sbjct: 2600 ----ATKTLPNGRD 2609
Score = 32.3 bits (72), Expect = 2.1
Identities = 72/389 (18%), Positives = 143/389 (36%), Gaps = 44/389 (11%)
Query: 59 LSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFV 118
L+ LR + E + L+E ++E L L +S E AA AG+
Sbjct: 1873 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA-----AGKA------- 1920
Query: 119 QKKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
L+ E R + E + + + +L+ A +R EEER R
Sbjct: 1921 ----------ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1970
Query: 179 ETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQ 238
E E Q ++ EE+ + + +E +++ + E+E ++ +
Sbjct: 1971 SLAAEEEAARQRKAALEEVERLKAKVEEARRL-------RERAEQESARQLQLAQEAAQK 2023
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKG 298
Q + + + + +Q V + +R G + + + +R +
Sbjct: 2024 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR--GEAEAARRAAEEAEEARVQ---- 2077
Query: 299 AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLA 358
AE E + RRQ ++A + E+ R +A A + + + RA +
Sbjct: 2078 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2137
Query: 359 IPAAQLVVLPYQMLLHAATRQAAGIR-----LQDQVVIIDEAHNLIDTTTSMHSVEVSGS 413
AA + ++ RQ A + L+ Q+ D NL+D + ++ +
Sbjct: 2138 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAEAT 2195
Query: 414 QLCQAHSQLLQYMERYGKRLKAKNLMYLK 442
+ + SQ+ + E + R++ + L LK
Sbjct: 2196 EAARQRSQVEE--ELFSVRVQMEELSKLK 2222
Score = 30.8 bits (68), Expect = 6.0
Identities = 26/109 (23%), Positives = 47/109 (43%), Gaps = 5/109 (4%)
Query: 121 KEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
+EE L + +AE+ R E + Q ++ +A + + E E +E R+ E++
Sbjct: 1323 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1382
Query: 181 GPEA-ERPEQLESGEEELVLAEYESDEE----KKVASGVDEDEDDLEEE 224
A + +Q S +EEL S+ E + A + +EEE
Sbjct: 1383 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1431
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 49.7 bits (117), Expect = 1e-05
Identities = 72/284 (25%), Positives = 119/284 (41%), Gaps = 35/284 (12%)
Query: 71 EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 124
EEE R+ LE + E L + E A R A E A + + VQ + +R
Sbjct: 1437 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1496
Query: 125 -----DLVNRLKAEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEERENLLRLSREML 178
+L +R+KAE ++++ LQ L+ R+Q + A +RLRQ E ER ++++ E
Sbjct: 1497 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1556
Query: 179 ETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQ 238
+ EAE + S E+ + E L+EEH+ + +
Sbjct: 1557 QRSAEAELQSKRASFAEKTA-----------------QLERSLQEEHVA-VAQLREEAER 1598
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKG 298
AQ E +++ + L R L NE +R + + + Q ++K+
Sbjct: 1599 RAQQQAEAERAREEAEREL----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1654
Query: 299 AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLA 342
AE E +R + E+QA EQ L + LAE ++L A
Sbjct: 1655 AEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAA 1697
Score = 46.2 bits (108), Expect = 1e-04
Identities = 80/378 (21%), Positives = 159/378 (42%), Gaps = 44/378 (11%)
Query: 68 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 127
+ ++ R L+ + +E+ LS + + AA + A E + + +K ++ +
Sbjct: 2243 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2302
Query: 128 NRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERP 187
++ E R K E LQQ + Q + A+RL++++E+ L + + EAER
Sbjct: 2303 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2359
Query: 188 EQLESGEE---------ELVLAEYESDEE----KKVASGVDEDEDDLE---EEHITKI-- 229
QLE E E+ A+ ++E+ +K A + E E +E +T +
Sbjct: 2360 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2419
Query: 230 ---------YHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQL 280
+ R +A+ E +K ++ +L+ L S + V ++ + L Q
Sbjct: 2420 LEIQRQQSDHDAERLREAIAEL--EREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQA 2476
Query: 281 INNRCVDMQRSRHEKKKGAEEEKPKRRR--QEKQAACPFYNHEQMGLLRDEALAEVKDME 338
+ + + S ++++ E+EK K + Q++ A EQ R + E ++ +
Sbjct: 2477 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQME-QERQ 2532
Query: 339 QLLALGKEARACPYYGSR-LAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHN 397
+L+A +EAR + + +L L Q RL++Q+ +++E H
Sbjct: 2533 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2592
Query: 398 LIDTTTSMHSVEVSGSQL 415
HS EV+ SQ+
Sbjct: 2593 ----AALAHSEEVTASQV 2606
Score = 39.7 bits (91), Expect = 0.013
Identities = 49/210 (23%), Positives = 86/210 (40%), Gaps = 17/210 (8%)
Query: 120 KKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML- 178
K EE+ + R AEQ KQR+ Q R+ + RLR E E+ E +L E L
Sbjct: 1664 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1723
Query: 179 ----ETGPEAERPEQLES------GEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITK 228
E ++ ++LE+ E E++LA EE+ S ++ + LE E +
Sbjct: 1724 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES-RSTSEKSKQRLEAE-AGR 1781
Query: 229 IYHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRC--- 285
+ ++L E K+ + + + E + ++G +
Sbjct: 1782 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1841
Query: 286 -VDMQRSRHEKKKGAEEEKPKRRRQEKQAA 314
+ + ++ AE+E +RRR E+QAA
Sbjct: 1842 LKEKEAENERLRRLAEDEAFQRRRLEEQAA 1871
Score = 36.6 bits (83), Expect = 0.11
Identities = 38/147 (25%), Positives = 68/147 (46%), Gaps = 12/147 (8%)
Query: 72 EEARL-LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVNRL 130
EEAR+ E + +E+ L S E A A A + ++K+ E++ R
Sbjct: 2080 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKLRKEAEQEAARRA 2136
Query: 131 KAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERPEQL 190
+AEQA +Q++ +++ K+A + LRQ+ + + L L ++ ET Q
Sbjct: 2137 QAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELTTLRLQLEET------DHQK 2188
Query: 191 ESGEEELVLAEYESDEEKKVASGVDED 217
+EEL + E+ E + S V+E+
Sbjct: 2189 NLLDEELQRLKAEATEAARQRSQVEEE 2215
Score = 36.2 bits (82), Expect = 0.14
Identities = 57/249 (22%), Positives = 104/249 (41%), Gaps = 30/249 (12%)
Query: 109 GEPAWVTQFVQKKEERDLVNRLKAEQARRKQRE-ERL-----QQLQHRVQLKYAAKRLRQ 162
GE + ++ EE + +A Q+RR+ E ERL +Q Q R Q + AA++LR+
Sbjct: 2067 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2126
Query: 163 EEEERENLLRLSREMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLE 222
E E+ A R + ++ + A+ E ++ KK A + +E
Sbjct: 2127 EAEQE---------------AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2171
Query: 223 EEHITKIYHCSRTHSQLAQFVHEVK--KSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQL 280
+E T T Q E++ K+ + R S + V + L ++
Sbjct: 2172 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2231
Query: 281 ---INNRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDM 337
NR + + R + ++ +EE K ++ ++AA ++ LR LAE +D+
Sbjct: 2232 RIEAENRAL-ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ--LAE-EDL 2287
Query: 338 EQLLALGKE 346
Q AL ++
Sbjct: 2288 AQQRALAEK 2296
Score = 35.8 bits (81), Expect = 0.19
Identities = 43/172 (25%), Positives = 72/172 (41%), Gaps = 24/172 (13%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
EQ++ EE RL E EK L + + A R A E +Q++ + +
Sbjct: 1338 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1386
Query: 126 LVNRLKAE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEERENLLR 172
+V R +A Q +++ +E LQQL+ + + AK RLR EEE R L+
Sbjct: 1387 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1446
Query: 173 LSREMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEE 224
L + G + L + EE + ++ EE + +DE + +
Sbjct: 1447 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1498
Score = 33.9 bits (76), Expect = 0.70
Identities = 47/194 (24%), Positives = 83/194 (42%), Gaps = 25/194 (12%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 122
E++K ++EA+LL+ + + + E L + + ++ Q K E
Sbjct: 2444 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2503
Query: 123 ERDLVNRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETG 181
+ KA+Q R +Q R+++ Q Q R +L + + R+ + E E +R +E
Sbjct: 2504 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2557
Query: 182 PEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSR-THSQLA 240
E ++ EQ +EEL+ E + + E LEE+H + H T SQ+A
Sbjct: 2558 -ELQQLEQQRRQQEELLAEENQR---------LREQLQLLEEQHRAALAHSEEVTASQVA 2607
Query: 241 QFVHEVKKSPFGKD 254
K P G+D
Sbjct: 2608 ----ATKTLPNGRD 2617
Score = 32.3 bits (72), Expect = 2.1
Identities = 72/389 (18%), Positives = 143/389 (36%), Gaps = 44/389 (11%)
Query: 59 LSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFV 118
L+ LR + E + L+E ++E L L +S E AA AG+
Sbjct: 1881 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA-----AGKA------- 1928
Query: 119 QKKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
L+ E R + E + + + +L+ A +R EEER R
Sbjct: 1929 ----------ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1978
Query: 179 ETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQ 238
E E Q ++ EE+ + + +E +++ + E+E ++ +
Sbjct: 1979 SLAAEEEAARQRKAALEEVERLKAKVEEARRL-------RERAEQESARQLQLAQEAAQK 2031
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKG 298
Q + + + + +Q V + +R G + + + +R +
Sbjct: 2032 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR--GEAEAARRAAEEAEEARVQ---- 2085
Query: 299 AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLA 358
AE E + RRQ ++A + E+ R +A A + + + RA +
Sbjct: 2086 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2145
Query: 359 IPAAQLVVLPYQMLLHAATRQAAGIR-----LQDQVVIIDEAHNLIDTTTSMHSVEVSGS 413
AA + ++ RQ A + L+ Q+ D NL+D + ++ +
Sbjct: 2146 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAEAT 2203
Query: 414 QLCQAHSQLLQYMERYGKRLKAKNLMYLK 442
+ + SQ+ + E + R++ + L LK
Sbjct: 2204 EAARQRSQVEE--ELFSVRVQMEELSKLK 2230
Score = 30.8 bits (68), Expect = 6.0
Identities = 26/109 (23%), Positives = 47/109 (43%), Gaps = 5/109 (4%)
Query: 121 KEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
+EE L + +AE+ R E + Q ++ +A + + E E +E R+ E++
Sbjct: 1331 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1390
Query: 181 GPEA-ERPEQLESGEEELVLAEYESDEE----KKVASGVDEDEDDLEEE 224
A + +Q S +EEL S+ E + A + +EEE
Sbjct: 1391 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1439
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 49.7 bits (117), Expect = 1e-05
Identities = 72/284 (25%), Positives = 119/284 (41%), Gaps = 35/284 (12%)
Query: 71 EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 124
EEE R+ LE + E L + E A R A E A + + VQ + +R
Sbjct: 1478 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1537
Query: 125 -----DLVNRLKAEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEERENLLRLSREML 178
+L +R+KAE ++++ LQ L+ R+Q + A +RLRQ E ER ++++ E
Sbjct: 1538 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1597
Query: 179 ETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQ 238
+ EAE + S E+ + E L+EEH+ + +
Sbjct: 1598 QRSAEAELQSKRASFAEKTA-----------------QLERSLQEEHVA-VAQLREEAER 1639
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKG 298
AQ E +++ + L R L NE +R + + + Q ++K+
Sbjct: 1640 RAQQQAEAERAREEAEREL----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1695
Query: 299 AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLA 342
AE E +R + E+QA EQ L + LAE ++L A
Sbjct: 1696 AEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAA 1738
Score = 46.2 bits (108), Expect = 1e-04
Identities = 80/378 (21%), Positives = 159/378 (42%), Gaps = 44/378 (11%)
Query: 68 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 127
+ ++ R L+ + +E+ LS + + AA + A E + + +K ++ +
Sbjct: 2284 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2343
Query: 128 NRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERP 187
++ E R K E LQQ + Q + A+RL++++E+ L + + EAER
Sbjct: 2344 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2400
Query: 188 EQLESGEE---------ELVLAEYESDEE----KKVASGVDEDEDDLE---EEHITKI-- 229
QLE E E+ A+ ++E+ +K A + E E +E +T +
Sbjct: 2401 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2460
Query: 230 ---------YHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQL 280
+ R +A+ E +K ++ +L+ L S + V ++ + L Q
Sbjct: 2461 LEIQRQQSDHDAERLREAIAEL--EREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQA 2517
Query: 281 INNRCVDMQRSRHEKKKGAEEEKPKRRR--QEKQAACPFYNHEQMGLLRDEALAEVKDME 338
+ + + S ++++ E+EK K + Q++ A EQ R + E ++ +
Sbjct: 2518 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQME-QERQ 2573
Query: 339 QLLALGKEARACPYYGSR-LAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHN 397
+L+A +EAR + + +L L Q RL++Q+ +++E H
Sbjct: 2574 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2633
Query: 398 LIDTTTSMHSVEVSGSQL 415
HS EV+ SQ+
Sbjct: 2634 ----AALAHSEEVTASQV 2647
Score = 39.7 bits (91), Expect = 0.013
Identities = 49/210 (23%), Positives = 86/210 (40%), Gaps = 17/210 (8%)
Query: 120 KKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML- 178
K EE+ + R AEQ KQR+ Q R+ + RLR E E+ E +L E L
Sbjct: 1705 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1764
Query: 179 ----ETGPEAERPEQLES------GEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITK 228
E ++ ++LE+ E E++LA EE+ S ++ + LE E +
Sbjct: 1765 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES-RSTSEKSKQRLEAE-AGR 1822
Query: 229 IYHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRC--- 285
+ ++L E K+ + + + E + ++G +
Sbjct: 1823 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1882
Query: 286 -VDMQRSRHEKKKGAEEEKPKRRRQEKQAA 314
+ + ++ AE+E +RRR E+QAA
Sbjct: 1883 LKEKEAENERLRRLAEDEAFQRRRLEEQAA 1912
Score = 36.6 bits (83), Expect = 0.11
Identities = 38/147 (25%), Positives = 68/147 (46%), Gaps = 12/147 (8%)
Query: 72 EEARL-LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVNRL 130
EEAR+ E + +E+ L S E A A A + ++K+ E++ R
Sbjct: 2121 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKLRKEAEQEAARRA 2177
Query: 131 KAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERPEQL 190
+AEQA +Q++ +++ K+A + LRQ+ + + L L ++ ET Q
Sbjct: 2178 QAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELTTLRLQLEET------DHQK 2229
Query: 191 ESGEEELVLAEYESDEEKKVASGVDED 217
+EEL + E+ E + S V+E+
Sbjct: 2230 NLLDEELQRLKAEATEAARQRSQVEEE 2256
Score = 36.2 bits (82), Expect = 0.14
Identities = 57/249 (22%), Positives = 104/249 (41%), Gaps = 30/249 (12%)
Query: 109 GEPAWVTQFVQKKEERDLVNRLKAEQARRKQRE-ERL-----QQLQHRVQLKYAAKRLRQ 162
GE + ++ EE + +A Q+RR+ E ERL +Q Q R Q + AA++LR+
Sbjct: 2108 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2167
Query: 163 EEEERENLLRLSREMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLE 222
E E+ A R + ++ + A+ E ++ KK A + +E
Sbjct: 2168 EAEQE---------------AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2212
Query: 223 EEHITKIYHCSRTHSQLAQFVHEVK--KSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQL 280
+E T T Q E++ K+ + R S + V + L ++
Sbjct: 2213 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2272
Query: 281 ---INNRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDM 337
NR + + R + ++ +EE K ++ ++AA ++ LR LAE +D+
Sbjct: 2273 RIEAENRAL-ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ--LAE-EDL 2328
Query: 338 EQLLALGKE 346
Q AL ++
Sbjct: 2329 AQQRALAEK 2337
Score = 35.8 bits (81), Expect = 0.19
Identities = 43/172 (25%), Positives = 72/172 (41%), Gaps = 24/172 (13%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
EQ++ EE RL E EK L + + A R A E +Q++ + +
Sbjct: 1379 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1427
Query: 126 LVNRLKAE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEERENLLR 172
+V R +A Q +++ +E LQQL+ + + AK RLR EEE R L+
Sbjct: 1428 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1487
Query: 173 LSREMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEE 224
L + G + L + EE + ++ EE + +DE + +
Sbjct: 1488 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1539
Score = 33.9 bits (76), Expect = 0.70
Identities = 47/194 (24%), Positives = 83/194 (42%), Gaps = 25/194 (12%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 122
E++K ++EA+LL+ + + + E L + + ++ Q K E
Sbjct: 2485 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2544
Query: 123 ERDLVNRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETG 181
+ KA+Q R +Q R+++ Q Q R +L + + R+ + E E +R +E
Sbjct: 2545 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2598
Query: 182 PEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSR-THSQLA 240
E ++ EQ +EEL+ E + + E LEE+H + H T SQ+A
Sbjct: 2599 -ELQQLEQQRRQQEELLAEENQR---------LREQLQLLEEQHRAALAHSEEVTASQVA 2648
Query: 241 QFVHEVKKSPFGKD 254
K P G+D
Sbjct: 2649 ----ATKTLPNGRD 2658
Score = 32.3 bits (72), Expect = 2.1
Identities = 72/389 (18%), Positives = 143/389 (36%), Gaps = 44/389 (11%)
Query: 59 LSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFV 118
L+ LR + E + L+E ++E L L +S E AA AG+
Sbjct: 1922 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA-----AGKA------- 1969
Query: 119 QKKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
L+ E R + E + + + +L+ A +R EEER R
Sbjct: 1970 ----------ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 2019
Query: 179 ETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQ 238
E E Q ++ EE+ + + +E +++ + E+E ++ +
Sbjct: 2020 SLAAEEEAARQRKAALEEVERLKAKVEEARRL-------RERAEQESARQLQLAQEAAQK 2072
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKG 298
Q + + + + +Q V + +R G + + + +R +
Sbjct: 2073 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR--GEAEAARRAAEEAEEARVQ---- 2126
Query: 299 AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLA 358
AE E + RRQ ++A + E+ R +A A + + + RA +
Sbjct: 2127 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2186
Query: 359 IPAAQLVVLPYQMLLHAATRQAAGIR-----LQDQVVIIDEAHNLIDTTTSMHSVEVSGS 413
AA + ++ RQ A + L+ Q+ D NL+D + ++ +
Sbjct: 2187 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAEAT 2244
Query: 414 QLCQAHSQLLQYMERYGKRLKAKNLMYLK 442
+ + SQ+ + E + R++ + L LK
Sbjct: 2245 EAARQRSQVEE--ELFSVRVQMEELSKLK 2271
Score = 30.8 bits (68), Expect = 6.0
Identities = 26/109 (23%), Positives = 47/109 (43%), Gaps = 5/109 (4%)
Query: 121 KEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
+EE L + +AE+ R E + Q ++ +A + + E E +E R+ E++
Sbjct: 1372 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1431
Query: 181 GPEA-ERPEQLESGEEELVLAEYESDEE----KKVASGVDEDEDDLEEE 224
A + +Q S +EEL S+ E + A + +EEE
Sbjct: 1432 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1480
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 47.8 bits (112), Expect = 5e-05
Identities = 52/209 (24%), Positives = 91/209 (43%), Gaps = 24/209 (11%)
Query: 116 QFVQKKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEER--ENLLRL 173
+ ++K+E L + + E A R+QREE +Q Q L+ +R R+EEE R E LLR
Sbjct: 778 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEA-LRRLEERRREEEERRKQEELLRK 836
Query: 174 SREMLE--TGPEAERPEQLESG----EEELVLAEYESDEEKKVASGVDEDEDDL----EE 223
E E E +LE EEE +E +E K+ V ++ + ++
Sbjct: 837 QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQ 896
Query: 224 EHITKIYHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINN 283
+ + + QLAQ + S +G+ S C ++ SL +Q +
Sbjct: 897 QEALRRLQQQQQQQQLAQ-MKLPSSSTWGQQ-------SNTTACQSQATLSLAEIQKLEE 948
Query: 284 RCVDMQRSRHEKKKGAEEEKPKRRRQEKQ 312
+ +R E+++ + E K +Q++Q
Sbjct: 949 ---ERERQLREEQRRQQRELMKALQQQQQ 974
Score = 40.8 bits (94), Expect = 0.006
Identities = 31/109 (28%), Positives = 52/109 (47%), Gaps = 8/109 (7%)
Query: 120 KKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE-----RENLLRLS 174
++E R+ R K E+ RK++EE +Q + ++ + +R R+EEEE +E LR
Sbjct: 732 EQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQ 791
Query: 175 REM---LETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDD 220
RE L E E +Q E L E +E +K + + E++
Sbjct: 792 REQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEE 840
Score = 33.1 bits (74), Expect = 1.2
Identities = 28/113 (24%), Positives = 50/113 (44%), Gaps = 23/113 (20%)
Query: 104 TPRPAGEPAWVTQFVQKKEERDLVNRLKAEQARR-------KQREERLQQLQHRVQLKYA 156
TP PA +++ ++ + K EQ RR ++ EER +Q + R Q +
Sbjct: 712 TPGPA---------LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEI 762
Query: 157 AKRLRQEEEERENLLRLSREMLETGPEAERPEQLESGEEELVLAEYESDEEKK 209
+R ++EE +R L+R E +R E+E+ L +EE++
Sbjct: 763 LRRQQEEERKRREEEELARRKQEEALRRQR-------EQEIALRRQREEEERQ 808
Score = 33.1 bits (74), Expect = 1.2
Identities = 51/213 (23%), Positives = 88/213 (41%), Gaps = 33/213 (15%)
Query: 142 ERLQQLQHRVQLKY------AAKRLRQEEEERENLLRLSREMLETGPEAERPEQLESGEE 195
E+LQQL+ K A R ++EEEER+ L R+ E + E+ EE
Sbjct: 718 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE 777
Query: 196 ELVLAEYES------DEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQLAQFVHEVKKS 249
EL + E ++E + +E+E +EE + ++ R + ++
Sbjct: 778 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE-----RRKQEE 832
Query: 250 PFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHE----KKKGAEEEKPK 305
K + +R+ E R L +L + R RHE K+K E ++ K
Sbjct: 833 LLRKQEEEAAKWAREE---EEAQRRLEENRLRMEE--EAARLRHEEEERKRKELEVQRQK 887
Query: 306 ---RRRQEKQAACPFYNHEQMGLLRDEALAEVK 335
R+RQ++Q A +Q + + LA++K
Sbjct: 888 ELMRQRQQQQEALRRLQQQQ----QQQQLAQMK 916
Score = 33.1 bits (74), Expect = 1.2
Identities = 40/141 (28%), Positives = 64/141 (45%), Gaps = 26/141 (18%)
Query: 120 KKEERDLVNRLKAEQARRKQRE--ERLQQLQHRVQLKYAAKRLRQEE-----EERENLLR 172
K+EE + R + E+ RR+Q E R Q+ + + + + R +QEE E+E LR
Sbjct: 743 KREEEE---RKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALR 799
Query: 173 LSREMLETGPEAE--------RPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEE 224
RE E + E R E+ E ++E +L + E +E K A +E + LEE
Sbjct: 800 RQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQE-EEAAKWAREEEEAQRRLEEN 858
Query: 225 HITKIYHCSRTHSQLAQFVHE 245
+ R + A+ HE
Sbjct: 859 RL-------RMEEEAARLRHE 872
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sapiens]
Length = 1320
Score = 47.8 bits (112), Expect = 5e-05
Identities = 52/209 (24%), Positives = 91/209 (43%), Gaps = 24/209 (11%)
Query: 116 QFVQKKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEER--ENLLRL 173
+ ++K+E L + + E A R+QREE +Q Q L+ +R R+EEE R E LLR
Sbjct: 805 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEA-LRRLEERRREEEERRKQEELLRK 863
Query: 174 SREMLE--TGPEAERPEQLESG----EEELVLAEYESDEEKKVASGVDEDEDDL----EE 223
E E E +LE EEE +E +E K+ V ++ + ++
Sbjct: 864 QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQ 923
Query: 224 EHITKIYHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINN 283
+ + + QLAQ + S +G+ S C ++ SL +Q +
Sbjct: 924 QEALRRLQQQQQQQQLAQ-MKLPSSSTWGQQ-------SNTTACQSQATLSLAEIQKLEE 975
Query: 284 RCVDMQRSRHEKKKGAEEEKPKRRRQEKQ 312
+ +R E+++ + E K +Q++Q
Sbjct: 976 ---ERERQLREEQRRQQRELMKALQQQQQ 1001
Score = 40.8 bits (94), Expect = 0.006
Identities = 31/109 (28%), Positives = 52/109 (47%), Gaps = 8/109 (7%)
Query: 120 KKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE-----RENLLRLS 174
++E R+ R K E+ RK++EE +Q + ++ + +R R+EEEE +E LR
Sbjct: 759 EQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQ 818
Query: 175 REM---LETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDD 220
RE L E E +Q E L E +E +K + + E++
Sbjct: 819 REQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEE 867
Score = 33.1 bits (74), Expect = 1.2
Identities = 28/113 (24%), Positives = 50/113 (44%), Gaps = 23/113 (20%)
Query: 104 TPRPAGEPAWVTQFVQKKEERDLVNRLKAEQARR-------KQREERLQQLQHRVQLKYA 156
TP PA +++ ++ + K EQ RR ++ EER +Q + R Q +
Sbjct: 739 TPGPA---------LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEI 789
Query: 157 AKRLRQEEEERENLLRLSREMLETGPEAERPEQLESGEEELVLAEYESDEEKK 209
+R ++EE +R L+R E +R E+E+ L +EE++
Sbjct: 790 LRRQQEEERKRREEEELARRKQEEALRRQR-------EQEIALRRQREEEERQ 835
Score = 33.1 bits (74), Expect = 1.2
Identities = 51/213 (23%), Positives = 88/213 (41%), Gaps = 33/213 (15%)
Query: 142 ERLQQLQHRVQLKY------AAKRLRQEEEERENLLRLSREMLETGPEAERPEQLESGEE 195
E+LQQL+ K A R ++EEEER+ L R+ E + E+ EE
Sbjct: 745 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE 804
Query: 196 ELVLAEYES------DEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQLAQFVHEVKKS 249
EL + E ++E + +E+E +EE + ++ R + ++
Sbjct: 805 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE-----RRKQEE 859
Query: 250 PFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHE----KKKGAEEEKPK 305
K + +R+ E R L +L + R RHE K+K E ++ K
Sbjct: 860 LLRKQEEEAAKWAREE---EEAQRRLEENRLRMEE--EAARLRHEEEERKRKELEVQRQK 914
Query: 306 ---RRRQEKQAACPFYNHEQMGLLRDEALAEVK 335
R+RQ++Q A +Q + + LA++K
Sbjct: 915 ELMRQRQQQQEALRRLQQQQ----QQQQLAQMK 943
Score = 33.1 bits (74), Expect = 1.2
Identities = 40/141 (28%), Positives = 64/141 (45%), Gaps = 26/141 (18%)
Query: 120 KKEERDLVNRLKAEQARRKQRE--ERLQQLQHRVQLKYAAKRLRQEE-----EERENLLR 172
K+EE + R + E+ RR+Q E R Q+ + + + + R +QEE E+E LR
Sbjct: 770 KREEEE---RKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALR 826
Query: 173 LSREMLETGPEAE--------RPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEE 224
RE E + E R E+ E ++E +L + E +E K A +E + LEE
Sbjct: 827 RQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQE-EEAAKWAREEEEAQRRLEEN 885
Query: 225 HITKIYHCSRTHSQLAQFVHE 245
+ R + A+ HE
Sbjct: 886 RL-------RMEEEAARLRHE 899
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 47.8 bits (112), Expect = 5e-05
Identities = 52/209 (24%), Positives = 91/209 (43%), Gaps = 24/209 (11%)
Query: 116 QFVQKKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEER--ENLLRL 173
+ ++K+E L + + E A R+QREE +Q Q L+ +R R+EEE R E LLR
Sbjct: 784 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEA-LRRLEERRREEEERRKQEELLRK 842
Query: 174 SREMLE--TGPEAERPEQLESG----EEELVLAEYESDEEKKVASGVDEDEDDL----EE 223
E E E +LE EEE +E +E K+ V ++ + ++
Sbjct: 843 QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQ 902
Query: 224 EHITKIYHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINN 283
+ + + QLAQ + S +G+ S C ++ SL +Q +
Sbjct: 903 QEALRRLQQQQQQQQLAQ-MKLPSSSTWGQQ-------SNTTACQSQATLSLAEIQKLEE 954
Query: 284 RCVDMQRSRHEKKKGAEEEKPKRRRQEKQ 312
+ +R E+++ + E K +Q++Q
Sbjct: 955 ---ERERQLREEQRRQQRELMKALQQQQQ 980
Score = 40.8 bits (94), Expect = 0.006
Identities = 31/109 (28%), Positives = 52/109 (47%), Gaps = 8/109 (7%)
Query: 120 KKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE-----RENLLRLS 174
++E R+ R K E+ RK++EE +Q + ++ + +R R+EEEE +E LR
Sbjct: 738 EQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQ 797
Query: 175 REM---LETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDD 220
RE L E E +Q E L E +E +K + + E++
Sbjct: 798 REQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEE 846
Score = 33.1 bits (74), Expect = 1.2
Identities = 28/113 (24%), Positives = 50/113 (44%), Gaps = 23/113 (20%)
Query: 104 TPRPAGEPAWVTQFVQKKEERDLVNRLKAEQARR-------KQREERLQQLQHRVQLKYA 156
TP PA +++ ++ + K EQ RR ++ EER +Q + R Q +
Sbjct: 718 TPGPA---------LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEI 768
Query: 157 AKRLRQEEEERENLLRLSREMLETGPEAERPEQLESGEEELVLAEYESDEEKK 209
+R ++EE +R L+R E +R E+E+ L +EE++
Sbjct: 769 LRRQQEEERKRREEEELARRKQEEALRRQR-------EQEIALRRQREEEERQ 814
Score = 33.1 bits (74), Expect = 1.2
Identities = 51/213 (23%), Positives = 88/213 (41%), Gaps = 33/213 (15%)
Query: 142 ERLQQLQHRVQLKY------AAKRLRQEEEERENLLRLSREMLETGPEAERPEQLESGEE 195
E+LQQL+ K A R ++EEEER+ L R+ E + E+ EE
Sbjct: 724 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE 783
Query: 196 ELVLAEYES------DEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQLAQFVHEVKKS 249
EL + E ++E + +E+E +EE + ++ R + ++
Sbjct: 784 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE-----RRKQEE 838
Query: 250 PFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHE----KKKGAEEEKPK 305
K + +R+ E R L +L + R RHE K+K E ++ K
Sbjct: 839 LLRKQEEEAAKWAREE---EEAQRRLEENRLRMEE--EAARLRHEEEERKRKELEVQRQK 893
Query: 306 ---RRRQEKQAACPFYNHEQMGLLRDEALAEVK 335
R+RQ++Q A +Q + + LA++K
Sbjct: 894 ELMRQRQQQQEALRRLQQQQ----QQQQLAQMK 922
Score = 33.1 bits (74), Expect = 1.2
Identities = 40/141 (28%), Positives = 64/141 (45%), Gaps = 26/141 (18%)
Query: 120 KKEERDLVNRLKAEQARRKQRE--ERLQQLQHRVQLKYAAKRLRQEE-----EERENLLR 172
K+EE + R + E+ RR+Q E R Q+ + + + + R +QEE E+E LR
Sbjct: 749 KREEEE---RKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALR 805
Query: 173 LSREMLETGPEAE--------RPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEE 224
RE E + E R E+ E ++E +L + E +E K A +E + LEE
Sbjct: 806 RQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQE-EEAAKWAREEEEAQRRLEEN 864
Query: 225 HITKIYHCSRTHSQLAQFVHE 245
+ R + A+ HE
Sbjct: 865 RL-------RMEEEAARLRHE 878
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 47.8 bits (112), Expect = 5e-05
Identities = 52/209 (24%), Positives = 91/209 (43%), Gaps = 24/209 (11%)
Query: 116 QFVQKKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEER--ENLLRL 173
+ ++K+E L + + E A R+QREE +Q Q L+ +R R+EEE R E LLR
Sbjct: 784 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEA-LRRLEERRREEEERRKQEELLRK 842
Query: 174 SREMLE--TGPEAERPEQLESG----EEELVLAEYESDEEKKVASGVDEDEDDL----EE 223
E E E +LE EEE +E +E K+ V ++ + ++
Sbjct: 843 QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQ 902
Query: 224 EHITKIYHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINN 283
+ + + QLAQ + S +G+ S C ++ SL +Q +
Sbjct: 903 QEALRRLQQQQQQQQLAQ-MKLPSSSTWGQQ-------SNTTACQSQATLSLAEIQKLEE 954
Query: 284 RCVDMQRSRHEKKKGAEEEKPKRRRQEKQ 312
+ +R E+++ + E K +Q++Q
Sbjct: 955 ---ERERQLREEQRRQQRELMKALQQQQQ 980
Score = 40.8 bits (94), Expect = 0.006
Identities = 31/109 (28%), Positives = 52/109 (47%), Gaps = 8/109 (7%)
Query: 120 KKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE-----RENLLRLS 174
++E R+ R K E+ RK++EE +Q + ++ + +R R+EEEE +E LR
Sbjct: 738 EQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQ 797
Query: 175 REM---LETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDD 220
RE L E E +Q E L E +E +K + + E++
Sbjct: 798 REQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEE 846
Score = 33.1 bits (74), Expect = 1.2
Identities = 28/113 (24%), Positives = 50/113 (44%), Gaps = 23/113 (20%)
Query: 104 TPRPAGEPAWVTQFVQKKEERDLVNRLKAEQARR-------KQREERLQQLQHRVQLKYA 156
TP PA +++ ++ + K EQ RR ++ EER +Q + R Q +
Sbjct: 718 TPGPA---------LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEI 768
Query: 157 AKRLRQEEEERENLLRLSREMLETGPEAERPEQLESGEEELVLAEYESDEEKK 209
+R ++EE +R L+R E +R E+E+ L +EE++
Sbjct: 769 LRRQQEEERKRREEEELARRKQEEALRRQR-------EQEIALRRQREEEERQ 814
Score = 33.1 bits (74), Expect = 1.2
Identities = 51/213 (23%), Positives = 88/213 (41%), Gaps = 33/213 (15%)
Query: 142 ERLQQLQHRVQLKY------AAKRLRQEEEERENLLRLSREMLETGPEAERPEQLESGEE 195
E+LQQL+ K A R ++EEEER+ L R+ E + E+ EE
Sbjct: 724 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE 783
Query: 196 ELVLAEYES------DEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQLAQFVHEVKKS 249
EL + E ++E + +E+E +EE + ++ R + ++
Sbjct: 784 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE-----RRKQEE 838
Query: 250 PFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHE----KKKGAEEEKPK 305
K + +R+ E R L +L + R RHE K+K E ++ K
Sbjct: 839 LLRKQEEEAAKWAREE---EEAQRRLEENRLRMEE--EAARLRHEEEERKRKELEVQRQK 893
Query: 306 ---RRRQEKQAACPFYNHEQMGLLRDEALAEVK 335
R+RQ++Q A +Q + + LA++K
Sbjct: 894 ELMRQRQQQQEALRRLQQQQ----QQQQLAQMK 922
Score = 33.1 bits (74), Expect = 1.2
Identities = 40/141 (28%), Positives = 64/141 (45%), Gaps = 26/141 (18%)
Query: 120 KKEERDLVNRLKAEQARRKQRE--ERLQQLQHRVQLKYAAKRLRQEE-----EERENLLR 172
K+EE + R + E+ RR+Q E R Q+ + + + + R +QEE E+E LR
Sbjct: 749 KREEEE---RKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALR 805
Query: 173 LSREMLETGPEAE--------RPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEE 224
RE E + E R E+ E ++E +L + E +E K A +E + LEE
Sbjct: 806 RQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQE-EEAAKWAREEEEAQRRLEEN 864
Query: 225 HITKIYHCSRTHSQLAQFVHE 245
+ R + A+ HE
Sbjct: 865 RL-------RMEEEAARLRHE 878
>gi|119120918 coiled-coil domain containing 64 [Homo sapiens]
Length = 573
Score = 47.8 bits (112), Expect = 5e-05
Identities = 54/246 (21%), Positives = 100/246 (40%), Gaps = 23/246 (9%)
Query: 71 EEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVNRL 130
EEE LL G P + S EGA P P+ +P ++ QK+++ L RL
Sbjct: 57 EEELALLAAGERPSDPGEHPQAEPGSLAEGAGPQPPPSQDPELLSVIRQKEKDLVLAARL 116
Query: 131 KAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERPEQL 190
R Q R + H+ +L + L QE+ E +RE G +E +
Sbjct: 117 GKALLERNQDMSRQYEQMHK-ELTDKLEHLEQEKHELRRRFE-NREGEWEGRVSELESDV 174
Query: 191 ESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQLAQFVHEVKKSP 250
+ ++EL + E + S ++ + + + ++ S QL+ VH +++
Sbjct: 175 KQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDF 234
Query: 251 FGKD-------VRLVSLGS--------------RQNLCVNEDVRSLGSVQLINNRCVDMQ 289
K+ +RL SL + R + + E+ G+V+ + +R + ++
Sbjct: 235 REKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILE 294
Query: 290 RSRHEK 295
R H+K
Sbjct: 295 RQGHDK 300
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 47.4 bits (111), Expect = 6e-05
Identities = 45/169 (26%), Positives = 76/169 (44%), Gaps = 14/169 (8%)
Query: 87 EKDESLC-LSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVNRLKAEQARRKQ---REE 142
EKDE+ S S E P GEP+ + + R RL+ E R + R++
Sbjct: 315 EKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQ 374
Query: 143 RLQQLQHRVQLKYAA-------KRLRQEEEERENLLRLSREMLETGPEAERPEQLESGEE 195
LQ+ Q R Q +Y KR+ Q++E+R L R E + ER ++ EE
Sbjct: 375 LLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEE 434
Query: 196 ELVLAEYE---SDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQLAQ 241
+ L E E +EE++ + ++ + E+E+I + + H ++ Q
Sbjct: 435 KRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQ 483
Score = 32.7 bits (73), Expect = 1.6
Identities = 17/62 (27%), Positives = 40/62 (64%), Gaps = 1/62 (1%)
Query: 119 QKKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQE-EEERENLLRLSREM 177
Q++ E++ RL+ + RRK+ EER + + + +++ + +R++ EEE+ +L L +++
Sbjct: 427 QRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQL 486
Query: 178 LE 179
L+
Sbjct: 487 LQ 488
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 47.4 bits (111), Expect = 6e-05
Identities = 45/169 (26%), Positives = 76/169 (44%), Gaps = 14/169 (8%)
Query: 87 EKDESLC-LSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVNRLKAEQARRKQ---REE 142
EKDE+ S S E P GEP+ + + R RL+ E R + R++
Sbjct: 315 EKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQ 374
Query: 143 RLQQLQHRVQLKYAA-------KRLRQEEEERENLLRLSREMLETGPEAERPEQLESGEE 195
LQ+ Q R Q +Y KR+ Q++E+R L R E + ER ++ EE
Sbjct: 375 LLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEE 434
Query: 196 ELVLAEYE---SDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQLAQ 241
+ L E E +EE++ + ++ + E+E+I + + H ++ Q
Sbjct: 435 KRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQ 483
Score = 32.7 bits (73), Expect = 1.6
Identities = 17/62 (27%), Positives = 40/62 (64%), Gaps = 1/62 (1%)
Query: 119 QKKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQE-EEERENLLRLSREM 177
Q++ E++ RL+ + RRK+ EER + + + +++ + +R++ EEE+ +L L +++
Sbjct: 427 QRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQL 486
Query: 178 LE 179
L+
Sbjct: 487 LQ 488
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.383
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,562,031
Number of Sequences: 37866
Number of extensions: 1636024
Number of successful extensions: 14066
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 161
Number of HSP's successfully gapped in prelim test: 516
Number of HSP's that attempted gapping in prelim test: 8997
Number of HSP's gapped (non-prelim): 3082
length of query: 906
length of database: 18,247,518
effective HSP length: 111
effective length of query: 795
effective length of database: 14,044,392
effective search space: 11165291640
effective search space used: 11165291640
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.