Search of human proteins with 205277463

Search of human proteins with 205277463

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|205277463 transketolase isoform 1 [Homo sapiens]
         (623 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|205277463 transketolase isoform 1 [Homo sapiens]                  1240   0.0  
gi|4507521 transketolase isoform 1 [Homo sapiens]                    1240   0.0  
gi|205277465 transketolase isoform 2 [Homo sapiens]                   967   0.0  
gi|133778974 transketolase-like 2 [Homo sapiens]                      851   0.0  
gi|225637459 transketolase-like 1 isoform a [Homo sapiens]            736   0.0  
gi|225637461 transketolase-like 1 isoform b [Homo sapiens]            717   0.0  
gi|225637463 transketolase-like 1 isoform c [Homo sapiens]            686   0.0  
gi|156564403 pyruvate dehydrogenase (lipoamide) beta [Homo sapiens]    51   3e-06
gi|11386135 branched chain keto acid dehydrogenase E1, alpha pol...    37   0.071
gi|4505685 pyruvate dehydrogenase E1 alpha 1 precursor [Homo sap...    35   0.27 
gi|32698918 NOL1/NOP2/Sun domain family, member 6 [Homo sapiens]       34   0.35 
gi|4885543 pyruvate dehydrogenase E1 alpha 2 [Homo sapiens]            32   2.3  
gi|82659109 retinoblastoma-associated factor 600 [Homo sapiens]        31   3.0  
gi|217416354 sphingosine kinase type 1-interacting protein isofo...    31   3.9  
gi|217416352 sphingosine kinase type 1-interacting protein isofo...    31   3.9  
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    30   5.1  

>gi|205277463 transketolase isoform 1 [Homo sapiens]
          Length = 623

 Score = 1240 bits (3208), Expect = 0.0
 Identities = 623/623 (100%), Positives = 623/623 (100%)

Query: 1   MESYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKS 60
           MESYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKS
Sbjct: 1   MESYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKS 60

Query: 61  QDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDV 120
           QDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDV
Sbjct: 61  QDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDV 120

Query: 121 ATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVA 180
           ATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVA
Sbjct: 121 ATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVA 180

Query: 181 ILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIA 240
           ILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIA
Sbjct: 181 ILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIA 240

Query: 241 KTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIAN 300
           KTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIAN
Sbjct: 241 KTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIAN 300

Query: 301 IRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFI 360
           IRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFI
Sbjct: 301 IRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFI 360

Query: 361 ECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVS 420
           ECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVS
Sbjct: 361 ECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVS 420

Query: 421 IGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAII 480
           IGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAII
Sbjct: 421 IGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAII 480

Query: 481 YNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPL 540
           YNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPL
Sbjct: 481 YNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPL 540

Query: 541 DRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAE 600
           DRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAE
Sbjct: 541 DRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAE 600

Query: 601 LLKMFGIDRDAIAQAVRGLITKA 623
           LLKMFGIDRDAIAQAVRGLITKA
Sbjct: 601 LLKMFGIDRDAIAQAVRGLITKA 623


>gi|4507521 transketolase isoform 1 [Homo sapiens]
          Length = 623

 Score = 1240 bits (3208), Expect = 0.0
 Identities = 623/623 (100%), Positives = 623/623 (100%)

Query: 1   MESYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKS 60
           MESYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKS
Sbjct: 1   MESYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKS 60

Query: 61  QDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDV 120
           QDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDV
Sbjct: 61  QDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDV 120

Query: 121 ATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVA 180
           ATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVA
Sbjct: 121 ATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVA 180

Query: 181 ILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIA 240
           ILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIA
Sbjct: 181 ILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIA 240

Query: 241 KTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIAN 300
           KTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIAN
Sbjct: 241 KTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIAN 300

Query: 301 IRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFI 360
           IRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFI
Sbjct: 301 IRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFI 360

Query: 361 ECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVS 420
           ECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVS
Sbjct: 361 ECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVS 420

Query: 421 IGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAII 480
           IGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAII
Sbjct: 421 IGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAII 480

Query: 481 YNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPL 540
           YNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPL
Sbjct: 481 YNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPL 540

Query: 541 DRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAE 600
           DRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAE
Sbjct: 541 DRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAE 600

Query: 601 LLKMFGIDRDAIAQAVRGLITKA 623
           LLKMFGIDRDAIAQAVRGLITKA
Sbjct: 601 LLKMFGIDRDAIAQAVRGLITKA 623


>gi|205277465 transketolase isoform 2 [Homo sapiens]
          Length = 540

 Score =  967 bits (2499), Expect = 0.0
 Identities = 492/512 (96%), Positives = 495/512 (96%), Gaps = 9/512 (1%)

Query: 121 ATGSLGQGLGAACGMA---------YTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFAS 171
           AT + G G   +C  A         +TGKYFDKASYRVYCLLGDGELSEGSVWEAMAFAS
Sbjct: 29  ATTAAGSGHPTSCCSAAEIMAVLFFHTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFAS 88

Query: 172 IYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQA 231
           IYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQA
Sbjct: 89  IYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQA 148

Query: 232 KHQPTAIIAKTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQE 291
           KHQPTAIIAKTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQE
Sbjct: 149 KHQPTAIIAKTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQE 208

Query: 292 DAPSVDIANIRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIF 351
           DAPSVDIANIRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIF
Sbjct: 209 DAPSVDIANIRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIF 268

Query: 352 KKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNIN 411
           KKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNIN
Sbjct: 269 KKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNIN 328

Query: 412 LCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIR 471
           LCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIR
Sbjct: 329 LCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIR 388

Query: 472 TSRPENAIIYNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRV 531
           TSRPENAIIYNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRV
Sbjct: 389 TSRPENAIIYNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRV 448

Query: 532 LDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNR 591
           LDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNR
Sbjct: 449 LDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNR 508

Query: 592 VPRSGKPAELLKMFGIDRDAIAQAVRGLITKA 623
           VPRSGKPAELLKMFGIDRDAIAQAVRGLITKA
Sbjct: 509 VPRSGKPAELLKMFGIDRDAIAQAVRGLITKA 540



 Score =  115 bits (289), Expect = 9e-26
 Identities = 56/58 (96%), Positives = 57/58 (98%)

Query: 1  MESYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRY 58
          MESYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHT +Y
Sbjct: 1  MESYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTGKY 58


>gi|133778974 transketolase-like 2 [Homo sapiens]
          Length = 626

 Score =  851 bits (2199), Expect = 0.0
 Identities = 415/614 (67%), Positives = 498/614 (81%), Gaps = 3/614 (0%)

Query: 6   KPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKSQDPRN 65
           KPD + +Q L+DTANRLRI SI+AT A+GSG  TSCCSAAE+++VLFFHTM+YK  DP +
Sbjct: 7   KPDVKTVQVLRDTANRLRIHSIRATCASGSGQLTSCCSAAEVVSVLFFHTMKYKQTDPEH 66

Query: 66  PHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDVATGSL 125
           P NDRF+LS+GHAAPILYA W E G ++E++LLNLRK+ SDL+ HP P+  F DVATGSL
Sbjct: 67  PDNDRFILSRGHAAPILYAAWVEVGDISESDLLNLRKLHSDLERHPTPRLPFVDVATGSL 126

Query: 126 GQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDIN 185
           GQGLG ACGMAYTGKY DKASYRV+CL+GDGE SEGSVWEA AFAS Y LDNLVA+ D+N
Sbjct: 127 GQGLGTACGMAYTGKYLDKASYRVFCLMGDGESSEGSVWEAFAFASHYNLDNLVAVFDVN 186

Query: 186 RLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQA---KHQPTAIIAKT 242
           RLGQS PAPL+H  DIYQ  CEAFGW+  +VDGH VE LC+AF QA   K++PTAI+AKT
Sbjct: 187 RLGQSGPAPLEHGADIYQNCCEAFGWNTYLVDGHDVEALCQAFWQASQVKNKPTAIVAKT 246

Query: 243 FKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIR 302
           FKGRGI  +ED E+WHGKP+PK  A+ I++ I SQIQ+ + ++   P ED+P + I +I+
Sbjct: 247 FKGRGIPNIEDAENWHGKPVPKERADAIVKLIESQIQTNENLIPKSPVEDSPQISITDIK 306

Query: 303 MPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFIEC 362
           M S P+YKVGDKIAT+K YG ALAKLG A++R+I L GDT NSTFSEIF+KEHP+RFIEC
Sbjct: 307 MTSPPAYKVGDKIATQKTYGLALAKLGRANERVIVLSGDTMNSTFSEIFRKEHPERFIEC 366

Query: 363 YIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVSIG 422
            IAEQNMVS+A+GCATR RT+ F   FAAFFTRAFDQ+RM AIS++NINL GSHCGVS G
Sbjct: 367 IIAEQNMVSVALGCATRGRTIAFAGAFAAFFTRAFDQLRMGAISQANINLIGSHCGVSTG 426

Query: 423 EDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYN 482
           EDG SQMALEDLAMFRS+P  TVFYPSD ++TE A+ LAANTKG+CFIRTS+PE A+IY 
Sbjct: 427 EDGVSQMALEDLAMFRSIPNCTVFYPSDAISTEHAIYLAANTKGMCFIRTSQPETAVIYT 486

Query: 483 NNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPLDR 542
             E+F++GQAKVV    +D+VTVIGAGVTLHEAL AA+ L ++ I++RV+DPFTIKPLD 
Sbjct: 487 PQENFEIGQAKVVRHGVNDKVTVIGAGVTLHEALEAADHLSQQGISVRVIDPFTIKPLDA 546

Query: 543 KLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAELL 602
             I+ SA+AT GR++TVEDHY EGGIGEAV +AV  EP I V  LAV+ VP+ GK +ELL
Sbjct: 547 ATIISSAKATGGRVITVEDHYREGGIGEAVCAAVSREPDILVHQLAVSGVPQRGKTSELL 606

Query: 603 KMFGIDRDAIAQAV 616
            MFGI    I  AV
Sbjct: 607 DMFGISTRHIIAAV 620


>gi|225637459 transketolase-like 1 isoform a [Homo sapiens]
          Length = 596

 Score =  736 bits (1900), Expect = 0.0
 Identities = 369/618 (59%), Positives = 461/618 (74%), Gaps = 41/618 (6%)

Query: 6   KPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKSQDPRN 65
           +PD+  LQ L+D A+RLRI SI+AT +  SGHPTSC S++EIM+VLFF+ MRYK  DP N
Sbjct: 15  RPDRGTLQVLQDMASRLRIHSIRATCSTSSGHPTSCSSSSEIMSVLFFYIMRYKQSDPEN 74

Query: 66  PHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDVATGSL 125
           P NDRFVL+K                                      + +F DVATG L
Sbjct: 75  PDNDRFVLAK--------------------------------------RLSFVDVATGWL 96

Query: 126 GQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDIN 185
           GQGLG ACGMAYTGKYFD+ASYRV+CL+ DGE SEGSVWEAMAFAS Y LDNLVAI D+N
Sbjct: 97  GQGLGVACGMAYTGKYFDRASYRVFCLMSDGESSEGSVWEAMAFASYYSLDNLVAIFDVN 156

Query: 186 RLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQA---KHQPTAIIAKT 242
           RLG S   P +H ++IYQ+RCEAFGW+  +VDG  VE LC+ F QA   KH+PTA++AKT
Sbjct: 157 RLGHSGALPAEHCINIYQRRCEAFGWNTYVVDGRDVEALCQVFWQASQVKHKPTAVVAKT 216

Query: 243 FKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIR 302
           FKGRG   +ED ESWH KP+P+  A+ II+ I SQIQ+ + +   PP ED+P V+I ++R
Sbjct: 217 FKGRGTPSIEDAESWHAKPMPRERADAIIKLIESQIQTSRNLDPQPPIEDSPEVNITDVR 276

Query: 303 MPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFIEC 362
           M S P Y+VGDKIATRKA G ALAKLG+A++R++ LDGDT+ STFSEIF KE+P+RFIEC
Sbjct: 277 MTSPPDYRVGDKIATRKACGLALAKLGYANNRVVVLDGDTRYSTFSEIFNKEYPERFIEC 336

Query: 363 YIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVSIG 422
           ++AEQNMVS+A+GCA+R RT+ F STFAAF TRAFD IR+  ++ESNIN+ GSHCGVS+G
Sbjct: 337 FMAEQNMVSVALGCASRGRTIAFASTFAAFLTRAFDHIRIGGLAESNINIIGSHCGVSVG 396

Query: 423 EDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYN 482
           +DG SQMALED+AMFR++P  T+FYP+D V+TE AV LAAN KG+CFIRT+RPE  +IY 
Sbjct: 397 DDGASQMALEDIAMFRTIPKCTIFYPTDAVSTEHAVALAANAKGMCFIRTTRPETMVIYT 456

Query: 483 NNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPLDR 542
             E F++GQAKV+     D+VTVIGAG+T++EALAAA+ L K+ I IRV+D FTIKPLD 
Sbjct: 457 PQERFEIGQAKVLRHCVSDKVTVIGAGITVYEALAAADELSKQDIFIRVIDLFTIKPLDV 516

Query: 543 KLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAELL 602
             I+ SA+AT+GRI+TVEDHY +GGIGEAV +AV  +P I V  LAV+ VP+SGK  ELL
Sbjct: 517 ATIVSSAKATEGRIITVEDHYPQGGIGEAVCAAVSMDPDIQVHSLAVSGVPQSGKSEELL 576

Query: 603 KMFGIDRDAIAQAVRGLI 620
            M+GI    I  AV+ ++
Sbjct: 577 DMYGISARHIIVAVKCML 594


>gi|225637461 transketolase-like 1 isoform b [Homo sapiens]
          Length = 590

 Score =  717 bits (1851), Expect = 0.0
 Identities = 364/618 (58%), Positives = 456/618 (73%), Gaps = 47/618 (7%)

Query: 6   KPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKSQDPRN 65
           +PD+  LQ L+D A+RLRI SI+AT +  SG      S++EIM+VLFF+ MRYK  DP N
Sbjct: 15  RPDRGTLQVLQDMASRLRIHSIRATCSTSSG------SSSEIMSVLFFYIMRYKQSDPEN 68

Query: 66  PHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDVATGSL 125
           P NDRFVL+K                                      + +F DVATG L
Sbjct: 69  PDNDRFVLAK--------------------------------------RLSFVDVATGWL 90

Query: 126 GQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDIN 185
           GQGLG ACGMAYTGKYFD+ASYRV+CL+ DGE SEGSVWEAMAFAS Y LDNLVAI D+N
Sbjct: 91  GQGLGVACGMAYTGKYFDRASYRVFCLMSDGESSEGSVWEAMAFASYYSLDNLVAIFDVN 150

Query: 186 RLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQA---KHQPTAIIAKT 242
           RLG S   P +H ++IYQ+RCEAFGW+  +VDG  VE LC+ F QA   KH+PTA++AKT
Sbjct: 151 RLGHSGALPAEHCINIYQRRCEAFGWNTYVVDGRDVEALCQVFWQASQVKHKPTAVVAKT 210

Query: 243 FKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIR 302
           FKGRG   +ED ESWH KP+P+  A+ II+ I SQIQ+ + +   PP ED+P V+I ++R
Sbjct: 211 FKGRGTPSIEDAESWHAKPMPRERADAIIKLIESQIQTSRNLDPQPPIEDSPEVNITDVR 270

Query: 303 MPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFIEC 362
           M S P Y+VGDKIATRKA G ALAKLG+A++R++ LDGDT+ STFSEIF KE+P+RFIEC
Sbjct: 271 MTSPPDYRVGDKIATRKACGLALAKLGYANNRVVVLDGDTRYSTFSEIFNKEYPERFIEC 330

Query: 363 YIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVSIG 422
           ++AEQNMVS+A+GCA+R RT+ F STFAAF TRAFD IR+  ++ESNIN+ GSHCGVS+G
Sbjct: 331 FMAEQNMVSVALGCASRGRTIAFASTFAAFLTRAFDHIRIGGLAESNINIIGSHCGVSVG 390

Query: 423 EDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYN 482
           +DG SQMALED+AMFR++P  T+FYP+D V+TE AV LAAN KG+CFIRT+RPE  +IY 
Sbjct: 391 DDGASQMALEDIAMFRTIPKCTIFYPTDAVSTEHAVALAANAKGMCFIRTTRPETMVIYT 450

Query: 483 NNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPLDR 542
             E F++GQAKV+     D+VTVIGAG+T++EALAAA+ L K+ I IRV+D FTIKPLD 
Sbjct: 451 PQERFEIGQAKVLRHCVSDKVTVIGAGITVYEALAAADELSKQDIFIRVIDLFTIKPLDV 510

Query: 543 KLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAELL 602
             I+ SA+AT+GRI+TVEDHY +GGIGEAV +AV  +P I V  LAV+ VP+SGK  ELL
Sbjct: 511 ATIVSSAKATEGRIITVEDHYPQGGIGEAVCAAVSMDPDIQVHSLAVSGVPQSGKSEELL 570

Query: 603 KMFGIDRDAIAQAVRGLI 620
            M+GI    I  AV+ ++
Sbjct: 571 DMYGISARHIIVAVKCML 588


>gi|225637463 transketolase-like 1 isoform c [Homo sapiens]
          Length = 540

 Score =  686 bits (1771), Expect = 0.0
 Identities = 344/576 (59%), Positives = 428/576 (74%), Gaps = 41/576 (7%)

Query: 48  MAVLFFHTMRYKSQDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDL 107
           M+VLFF+ MRYK  DP NP NDRFVL+K                                
Sbjct: 1   MSVLFFYIMRYKQSDPENPDNDRFVLAK-------------------------------- 28

Query: 108 DGHPVPKQAFTDVATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAM 167
                 + +F DVATG LGQGLG ACGMAYTGKYFD+ASYRV+CL+ DGE SEGSVWEAM
Sbjct: 29  ------RLSFVDVATGWLGQGLGVACGMAYTGKYFDRASYRVFCLMSDGESSEGSVWEAM 82

Query: 168 AFASIYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKA 227
           AFAS Y LDNLVAI D+NRLG S   P +H ++IYQ+RCEAFGW+  +VDG  VE LC+ 
Sbjct: 83  AFASYYSLDNLVAIFDVNRLGHSGALPAEHCINIYQRRCEAFGWNTYVVDGRDVEALCQV 142

Query: 228 FGQA---KHQPTAIIAKTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKI 284
           F QA   KH+PTA++AKTFKGRG   +ED ESWH KP+P+  A+ II+ I SQIQ+ + +
Sbjct: 143 FWQASQVKHKPTAVVAKTFKGRGTPSIEDAESWHAKPMPRERADAIIKLIESQIQTSRNL 202

Query: 285 LATPPQEDAPSVDIANIRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKN 344
              PP ED+P V+I ++RM S P Y+VGDKIATRKA G ALAKLG+A++R++ LDGDT+ 
Sbjct: 203 DPQPPIEDSPEVNITDVRMTSPPDYRVGDKIATRKACGLALAKLGYANNRVVVLDGDTRY 262

Query: 345 STFSEIFKKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAA 404
           STFSEIF KE+P+RFIEC++AEQNMVS+A+GCA+R RT+ F STFAAF TRAFD IR+  
Sbjct: 263 STFSEIFNKEYPERFIECFMAEQNMVSVALGCASRGRTIAFASTFAAFLTRAFDHIRIGG 322

Query: 405 ISESNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANT 464
           ++ESNIN+ GSHCGVS+G+DG SQMALED+AMFR++P  T+FYP+D V+TE AV LAAN 
Sbjct: 323 LAESNINIIGSHCGVSVGDDGASQMALEDIAMFRTIPKCTIFYPTDAVSTEHAVALAANA 382

Query: 465 KGICFIRTSRPENAIIYNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKK 524
           KG+CFIRT+RPE  +IY   E F++GQAKV+     D+VTVIGAG+T++EALAAA+ L K
Sbjct: 383 KGMCFIRTTRPETMVIYTPQERFEIGQAKVLRHCVSDKVTVIGAGITVYEALAAADELSK 442

Query: 525 EKINIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITV 584
           + I IRV+D FTIKPLD   I+ SA+AT+GRI+TVEDHY +GGIGEAV +AV  +P I V
Sbjct: 443 QDIFIRVIDLFTIKPLDVATIVSSAKATEGRIITVEDHYPQGGIGEAVCAAVSMDPDIQV 502

Query: 585 THLAVNRVPRSGKPAELLKMFGIDRDAIAQAVRGLI 620
             LAV+ VP+SGK  ELL M+GI    I  AV+ ++
Sbjct: 503 HSLAVSGVPQSGKSEELLDMYGISARHIIVAVKCML 538


>gi|156564403 pyruvate dehydrogenase (lipoamide) beta [Homo sapiens]
          Length = 359

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 64/277 (23%), Positives = 110/277 (39%), Gaps = 34/277 (12%)

Query: 350 IFKKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFT-RAFDQIRMAAISES 408
           ++KK    R I+  I+E     IAVG A      P C      F+ +A DQ+  +A    
Sbjct: 73  LWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLR-PICEFMTFNFSMQAIDQVINSAAK-- 129

Query: 409 NINLCGSHCGVSIGEDGPS--------QMALEDLAMFRSVPTSTVFYPSDGVATEKAVEL 460
              + G    V I   GP+        Q +    A +   P   V  P +    +  ++ 
Sbjct: 130 TYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKS 189

Query: 461 AANTKGICFIRTSRP----ENAIIYN---------NNEDFQVGQAKVVLKSKDDQVTVIG 507
           A        IR + P    EN ++Y           ++DF +   K  ++ +   +TV+ 
Sbjct: 190 A--------IRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVVS 241

Query: 508 AGVTLHEALAAAELLKKEKINIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGG 567
               +   L AA +L KE +   V++  TI+P+D + I  S   T   ++TVE  + + G
Sbjct: 242 HSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKT-NHLVTVEGGWPQFG 300

Query: 568 IGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAELLKM 604
           +G  + + ++  P          RV  +  P    K+
Sbjct: 301 VGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKI 337


>gi|11386135 branched chain keto acid dehydrogenase E1, alpha
           polypeptide [Homo sapiens]
          Length = 445

 Score = 36.6 bits (83), Expect = 0.071
 Identities = 34/119 (28%), Positives = 52/119 (43%), Gaps = 8/119 (6%)

Query: 132 ACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDINRLGQSD 191
           A G AY  K  + A+  V C  G+G  SEG       FA+  +   ++     N    S 
Sbjct: 216 AVGAAYAAKRAN-ANRVVICYFGEGAASEGDAHAGFNFAATLECP-IIFFCRNNGYAIST 273

Query: 192 PAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQAK------HQPTAIIAKTFK 244
           P   Q++ D    R   +G  +I VDG+ V  +  A  +A+      +QP  I A T++
Sbjct: 274 PTSEQYRGDGIAARGPGYGIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYR 332


>gi|4505685 pyruvate dehydrogenase E1 alpha 1 precursor [Homo
           sapiens]
          Length = 390

 Score = 34.7 bits (78), Expect = 0.27
 Identities = 26/81 (32%), Positives = 38/81 (46%), Gaps = 8/81 (9%)

Query: 125 LGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDI 184
           LG G+  AC   Y GK  D+    +Y   GDG  ++G ++EA   A+++KL   + I + 
Sbjct: 173 LGAGIALAC--KYNGK--DEVCLTLY---GDGAANQGQIFEAYNMAALWKLP-CIFICEN 224

Query: 185 NRLGQSDPAPLQHQMDIYQKR 205
           NR G             Y KR
Sbjct: 225 NRYGMGTSVERAAASTDYYKR 245


>gi|32698918 NOL1/NOP2/Sun domain family, member 6 [Homo sapiens]
          Length = 469

 Score = 34.3 bits (77), Expect = 0.35
 Identities = 26/99 (26%), Positives = 43/99 (43%), Gaps = 1/99 (1%)

Query: 241 KTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIAN 300
           K F G GI+ +  KE + G P  K M  ++ + +Y        +      ++ PS  +++
Sbjct: 169 KVFLGNGISELSRKEIFSGLPELKGMGIRMTEPVYLSPSFDSVLPRYLFLQNLPSALVSH 228

Query: 301 IRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALD 339
           +  P  P  K+ D  A        +A L H    +IALD
Sbjct: 229 VLNPQ-PGEKILDLCAAPGGKTTHIAALMHDQGEVIALD 266


>gi|4885543 pyruvate dehydrogenase E1 alpha 2 [Homo sapiens]
          Length = 388

 Score = 31.6 bits (70), Expect = 2.3
 Identities = 27/85 (31%), Positives = 37/85 (43%), Gaps = 8/85 (9%)

Query: 121 ATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVA 180
           A G LG G+  AC   Y G   D+    +Y   GDG  ++G + EA   A+++KL   V 
Sbjct: 167 AQGPLGAGIALAC--KYKGN--DEICLTLY---GDGAANQGQIAEAFNMAALWKLP-CVF 218

Query: 181 ILDINRLGQSDPAPLQHQMDIYQKR 205
           I + N  G             Y KR
Sbjct: 219 ICENNLYGMGTSTERAAASPDYYKR 243


>gi|82659109 retinoblastoma-associated factor 600 [Homo sapiens]
          Length = 5183

 Score = 31.2 bits (69), Expect = 3.0
 Identities = 16/47 (34%), Positives = 26/47 (55%), Gaps = 1/47 (2%)

Query: 369  MVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGS 415
            +V I +  A  N +  FC+    FFT+ F Q+   + + S ++LCGS
Sbjct: 1407 LVQIMMATANENLSAKFCNRVLKFFTKLF-QLTEKSPNPSLLHLCGS 1452


>gi|217416354 sphingosine kinase type 1-interacting protein isoform
           1 [Homo sapiens]
          Length = 1700

 Score = 30.8 bits (68), Expect = 3.9
 Identities = 20/67 (29%), Positives = 34/67 (50%), Gaps = 6/67 (8%)

Query: 252 EDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIRMPSLPSYKV 311
           +D E   GK    N+AE ++Q+ + ++   +  L   PQE A SV + +  +PS   Y  
Sbjct: 382 QDGEVTTGK-YATNLAESVLQDAFIRLSQSQSTL---PQESAVSVSVGSSLLPS--CYST 435

Query: 312 GDKIATR 318
            D + +R
Sbjct: 436 KDTVVSR 442


>gi|217416352 sphingosine kinase type 1-interacting protein isoform
           2 [Homo sapiens]
          Length = 1671

 Score = 30.8 bits (68), Expect = 3.9
 Identities = 20/67 (29%), Positives = 34/67 (50%), Gaps = 6/67 (8%)

Query: 252 EDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIRMPSLPSYKV 311
           +D E   GK    N+AE ++Q+ + ++   +  L   PQE A SV + +  +PS   Y  
Sbjct: 382 QDGEVTTGK-YATNLAESVLQDAFIRLSQSQSTL---PQESAVSVSVGSSLLPS--CYST 435

Query: 312 GDKIATR 318
            D + +R
Sbjct: 436 KDTVVSR 442


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 30.4 bits (67), Expect = 5.1
 Identities = 26/106 (24%), Positives = 44/106 (41%), Gaps = 19/106 (17%)

Query: 247 GITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIRMPSL 306
           G+  + D+E W  K   K   E+++QE  S  + +K      P++     D   I     
Sbjct: 530 GVLALLDEECWFPKATDKTFVEKLVQEQGSHSKFQK------PRQLKDKADFCIIHYAGK 583

Query: 307 PSYK-----------VGDKIAT--RKAYGQALAKLGHASDRIIALD 339
             YK           + D +AT   ++  + +A+L    DRI+ LD
Sbjct: 584 VDYKADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKDVDRIVGLD 629


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.133    0.389 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,382,521
Number of Sequences: 37866
Number of extensions: 963403
Number of successful extensions: 2137
Number of sequences better than 10.0: 16
Number of HSP's better than 10.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 2118
Number of HSP's gapped (non-prelim): 22
length of query: 623
length of database: 18,247,518
effective HSP length: 108
effective length of query: 515
effective length of database: 14,157,990
effective search space: 7291364850
effective search space used: 7291364850
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.