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Search of human proteins with 20336726
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20336726 ceramide kinase [Homo sapiens]
(537 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20336726 ceramide kinase [Homo sapiens] 1117 0.0
gi|41680688 ceramide kinase-like isoform a [Homo sapiens] 209 5e-54
gi|71896723 ceramide kinase-like isoform b [Homo sapiens] 195 1e-49
gi|237757361 ceramide kinase-like isoform g [Homo sapiens] 151 1e-36
gi|71896711 ceramide kinase-like isoform d [Homo sapiens] 116 5e-26
gi|71896725 ceramide kinase-like isoform c [Homo sapiens] 113 4e-25
gi|21361699 sphingosine kinase 2 [Homo sapiens] 102 7e-22
gi|217272885 sphingosine kinase 1 isoform 3 [Homo sapiens] 94 4e-19
gi|217272883 sphingosine kinase 1 isoform 3 [Homo sapiens] 94 4e-19
gi|21361088 sphingosine kinase 1 isoform 1 [Homo sapiens] 94 4e-19
gi|217272880 sphingosine kinase 1 isoform 2 [Homo sapiens] 94 4e-19
gi|8922701 acylglycerol kinase [Homo sapiens] 72 2e-12
gi|189027129 phosphodiesterase 12 [Homo sapiens] 30 5.6
gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens] 30 7.3
gi|46255064 synaptotagmin-like 2 isoform d [Homo sapiens] 29 9.5
gi|46255062 synaptotagmin-like 2 isoform c [Homo sapiens] 29 9.5
gi|95147335 inositol 1,4,5-triphosphate receptor, type 2 [Homo s... 29 9.5
gi|4826988 ribosomal protein L3-like [Homo sapiens] 29 9.5
>gi|20336726 ceramide kinase [Homo sapiens]
Length = 537
Score = 1117 bits (2888), Expect = 0.0
Identities = 537/537 (100%), Positives = 537/537 (100%)
Query: 1 MGATGAAEPLQSVLWVKQQRCAVSLEPARALLRWWRSPGPGAGAPGADACSVPVSEIIAV 60
MGATGAAEPLQSVLWVKQQRCAVSLEPARALLRWWRSPGPGAGAPGADACSVPVSEIIAV
Sbjct: 1 MGATGAAEPLQSVLWVKQQRCAVSLEPARALLRWWRSPGPGAGAPGADACSVPVSEIIAV 60
Query: 61 EETDVHGKHQGSGKWQKMEKPYAFTVHCVKRARRHRWKWAQVTFWCPEEQLCHLWLQTLR 120
EETDVHGKHQGSGKWQKMEKPYAFTVHCVKRARRHRWKWAQVTFWCPEEQLCHLWLQTLR
Sbjct: 61 EETDVHGKHQGSGKWQKMEKPYAFTVHCVKRARRHRWKWAQVTFWCPEEQLCHLWLQTLR 120
Query: 121 EMLEKLTSRPKHLLVFINPFGGKGQGKRIYERKVAPLFTLASITTDIIVTEHANQAKETL 180
EMLEKLTSRPKHLLVFINPFGGKGQGKRIYERKVAPLFTLASITTDIIVTEHANQAKETL
Sbjct: 121 EMLEKLTSRPKHLLVFINPFGGKGQGKRIYERKVAPLFTLASITTDIIVTEHANQAKETL 180
Query: 181 YEINIDKYDGIVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHPRAVLVPSSLRIGIIPAGS 240
YEINIDKYDGIVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHPRAVLVPSSLRIGIIPAGS
Sbjct: 181 YEINIDKYDGIVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHPRAVLVPSSLRIGIIPAGS 240
Query: 241 TDCVCYSTVGTSDAETSALHIVVGDSLAMDVSSVHHNSTLLRYSVSLLGYGFYGDIIKDS 300
TDCVCYSTVGTSDAETSALHIVVGDSLAMDVSSVHHNSTLLRYSVSLLGYGFYGDIIKDS
Sbjct: 241 TDCVCYSTVGTSDAETSALHIVVGDSLAMDVSSVHHNSTLLRYSVSLLGYGFYGDIIKDS 300
Query: 301 EKKRWLGLARYDFSGLKTFLSHHCYEGTVSFLPAQHTVGSPRDRKPCRAGCFVCRQSKQQ 360
EKKRWLGLARYDFSGLKTFLSHHCYEGTVSFLPAQHTVGSPRDRKPCRAGCFVCRQSKQQ
Sbjct: 301 EKKRWLGLARYDFSGLKTFLSHHCYEGTVSFLPAQHTVGSPRDRKPCRAGCFVCRQSKQQ 360
Query: 361 LEEEQKKALYGLEAAEDVEEWQVVCGKFLAINATNMSCACRRSPRGLSPAAHLGDGSSDL 420
LEEEQKKALYGLEAAEDVEEWQVVCGKFLAINATNMSCACRRSPRGLSPAAHLGDGSSDL
Sbjct: 361 LEEEQKKALYGLEAAEDVEEWQVVCGKFLAINATNMSCACRRSPRGLSPAAHLGDGSSDL 420
Query: 421 ILIRKCSRFNFLRFLIRHTNQQDQFDFTFVEVYRVKKFQFTSKHMEDEDSDLKEGGKKRF 480
ILIRKCSRFNFLRFLIRHTNQQDQFDFTFVEVYRVKKFQFTSKHMEDEDSDLKEGGKKRF
Sbjct: 421 ILIRKCSRFNFLRFLIRHTNQQDQFDFTFVEVYRVKKFQFTSKHMEDEDSDLKEGGKKRF 480
Query: 481 GHICSSHPSCCCTVSNSSWNCDGEVLHSPAIEVRVHCQLVRLFARGIEENPKPDSHS 537
GHICSSHPSCCCTVSNSSWNCDGEVLHSPAIEVRVHCQLVRLFARGIEENPKPDSHS
Sbjct: 481 GHICSSHPSCCCTVSNSSWNCDGEVLHSPAIEVRVHCQLVRLFARGIEENPKPDSHS 537
>gi|41680688 ceramide kinase-like isoform a [Homo sapiens]
Length = 532
Score = 209 bits (532), Expect = 5e-54
Identities = 149/532 (28%), Positives = 256/532 (48%), Gaps = 63/532 (11%)
Query: 10 LQSVLWVKQQRCAVSLEPARALLRWWRSPGPGAGAPGADACSVPVSEIIAVEET-DVHGK 68
L+ + + + C V L RAL WR P A + + E I +++ V K
Sbjct: 48 LRGIFEIGRDSCDVVLSE-RALR--WRPIQPERPAGDSKYDLLCKEEFIELKDIFSVKLK 104
Query: 69 HQGSGKWQKMEKPYAFTVHCVKRARRHRWKWAQVTFWCPEEQLCHLWLQTLREMLEKLTS 128
+ S K Q+ T+ + +++ K + + E C +W + +++L +
Sbjct: 105 RRCSVKQQRSGTLLGITLFICLKKEQNKLKNSTLDLINLSEDHCDIWFRQFKKILAGFPN 164
Query: 129 RPKHLLVFINPFGGKGQGKRIYERKVAPLFTLASITTDIIVTEHANQAKETLYEINIDKY 188
RPK L + +NP K + ++Y KV PL LA I TD+ + E+ A L E + +
Sbjct: 165 RPKSLKILLNPQSHKKEATQVYYEKVEPLLKLAGIKTDVTIMEYEGHALSLLKECELQGF 224
Query: 189 DGIVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHPRAVLVP--SSLRIGIIPAGSTDCVCY 246
DG+VCVGGDG SEV H L+ R Q++AG++ + +L P + L +G+IPAGST+ + +
Sbjct: 225 DGVVCVGGDGSASEVAHALLLRAQKNAGMETDR---ILTPVRAQLPLGLIPAGSTNVLAH 281
Query: 247 STVGTSDAETSALHIVVGDSLAMDVSSVHHNSTLLRYSVSLLGYGFYGDIIKDSEKKRWL 306
S G T+ LHI++G +DV + LLR+ S + +GF G + +EK RW+
Sbjct: 282 SLHGVPHVITATLHIIMGHVQLVDVCTFSTAGKLLRFGFSAM-FGFGGRTLALAEKYRWM 340
Query: 307 G-LARYDFSGLKTFLSHHCYEGTVSFLPAQHTVGSPRDRKPCRAGCFVCRQSKQQLEEEQ 365
R DF+ +K + +SFLP + ++ Q
Sbjct: 341 SPNQRRDFAVVKALAKLKAEDCEISFLPFNSS------------------------DDVQ 376
Query: 366 KKALYGLEAAEDVEEWQVVCGKFLAINATNMSCACRRSPRGLSPAAHLGDGSSDLILIRK 425
++ G ++ ++WQ++ G+FL ++ + C C +PRGL+P L +GS LI+ R
Sbjct: 377 ERRAQGSPKSDCNDQWQMIQGQFLNVSIMAIPCLCSVAPRGLAPNTRLNNGSMALIIARN 436
Query: 426 CSRFNFLRFLIRHTNQQDQFDFTFVEVYRVKKFQFTSKH-------MEDEDSDLKEGGKK 478
SR F++ L R+ + ++QF+F FVE Y V++ + ++ E+ED E
Sbjct: 437 TSRPEFIKHLKRYASVKNQFNFPFVETYTVEEVKVHPRNNTGGYNPEEEEDETASE---- 492
Query: 479 RFGHICSSHPSCCCTVSNSSWNCDGEVLH-SPAIEVRVHCQLVRLFARGIEE 529
+C WN DG+++ + + +R+H +L+ L+ +EE
Sbjct: 493 ----------NC------FPWNVDGDLMEVASEVHIRLHPRLISLYGGSMEE 528
>gi|71896723 ceramide kinase-like isoform b [Homo sapiens]
Length = 558
Score = 195 bits (495), Expect = 1e-49
Identities = 149/558 (26%), Positives = 256/558 (45%), Gaps = 89/558 (15%)
Query: 10 LQSVLWVKQQRCAVSLEPARALLRWWRSPGPGAGAPGADACSVPVSEIIAVEET-DVHGK 68
L+ + + + C V L RAL WR P A + + E I +++ V K
Sbjct: 48 LRGIFEIGRDSCDVVLSE-RALR--WRPIQPERPAGDSKYDLLCKEEFIELKDIFSVKLK 104
Query: 69 HQGSGKWQKMEKPYAFTVHCVKRARRHRWKWAQVTFWCPEEQLCHLWLQTLREMLEKLTS 128
+ S K Q+ T+ + +++ K + + E C +W + +++L +
Sbjct: 105 RRCSVKQQRSGTLLGITLFICLKKEQNKLKNSTLDLINLSEDHCDIWFRQFKKILAGFPN 164
Query: 129 RPKHLLVFINPFGGKGQGKRIYERKVAPLFTLASITTDIIVTEHANQAKETLYEINIDKY 188
RPK L + +NP K + ++Y KV PL LA I TD+ + E+ A L E + +
Sbjct: 165 RPKSLKILLNPQSHKKEATQVYYEKVEPLLKLAGIKTDVTIMEYEGHALSLLKECELQGF 224
Query: 189 DG--------------------------IVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHP 222
DG +VCVGGDG SEV H L+ R Q++AG++ +
Sbjct: 225 DGGHRKPLFAIHWSVQRLFTGMQTLEPSVVCVGGDGSASEVAHALLLRAQKNAGMETDR- 283
Query: 223 RAVLVP--SSLRIGIIPAGSTDCVCYSTVGTSDAETSALHIVVGDSLAMDVSSVHHNSTL 280
+L P + L +G+IPAGST+ + +S G T+ LHI++G +DV + L
Sbjct: 284 --ILTPVRAQLPLGLIPAGSTNVLAHSLHGVPHVITATLHIIMGHVQLVDVCTFSTAGKL 341
Query: 281 LRYSVSLLGYGFYGDIIKDSEKKRWLGL-ARYDFSGLKTFLSHHCYEGTVSFLPAQHTVG 339
LR+ S + +GF G + +EK RW+ R DF+ +K + +SFLP +
Sbjct: 342 LRFGFSAM-FGFGGRTLALAEKYRWMSPNQRRDFAVVKALAKLKAEDCEISFLPFNSS-- 398
Query: 340 SPRDRKPCRAGCFVCRQSKQQLEEEQKKALYGLEAAEDVEEWQVVCGKFLAINATNMSCA 399
++ Q++ G ++ ++WQ++ G+FL ++ + C
Sbjct: 399 ----------------------DDVQERRAQGSPKSDCNDQWQMIQGQFLNVSIMAIPCL 436
Query: 400 CRRSPRGLSPAAHLGDGSSDLILIRKCSRFNFLRFLIRHTNQQDQFDFTFVEVYRVKKFQ 459
C +PRGL+P L +GS LI+ R SR F++ L R+ + ++QF+F FVE Y V++ +
Sbjct: 437 CSVAPRGLAPNTRLNNGSMALIIARNTSRPEFIKHLKRYASVKNQFNFPFVETYTVEEVK 496
Query: 460 FTSKH-------MEDEDSDLKEGGKKRFGHICSSHPSCCCTVSNSSWNCDGEVLH-SPAI 511
++ E+ED E +C WN DG+++ + +
Sbjct: 497 VHPRNNTGGYNPEEEEDETASE--------------NC------FPWNVDGDLMEVASEV 536
Query: 512 EVRVHCQLVRLFARGIEE 529
+R+H +L+ L+ +EE
Sbjct: 537 HIRLHPRLISLYGGSMEE 554
>gi|237757361 ceramide kinase-like isoform g [Homo sapiens]
Length = 514
Score = 151 bits (382), Expect = 1e-36
Identities = 102/350 (29%), Positives = 175/350 (50%), Gaps = 59/350 (16%)
Query: 191 IVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHPRAVLVP--SSLRIGIIPAGSTDCVCYST 248
+VCVGGDG SEV H L+ R Q++AG++ + +L P + L +G+IPAGST+ + +S
Sbjct: 209 VVCVGGDGSASEVAHALLLRAQKNAGMETDR---ILTPVRAQLPLGLIPAGSTNVLAHSL 265
Query: 249 VGTSDAETSALHIVVGDSLAMDVSSVHHNSTLLRYSVSLLGYGFYGDIIKDSEKKRWLGL 308
G T+ LHI++G +DV + LLR+ S + +GF G + +EK RW+
Sbjct: 266 HGVPHVITATLHIIMGHVQLVDVCTFSTAGKLLRFGFSAM-FGFGGRTLALAEKYRWMSP 324
Query: 309 -ARYDFSGLKTFLSHHCYEGTVSFLPAQHTVGSPRDRKPCRAGCFVCRQSKQQLEEEQKK 367
R DF+ +K + +SFLP + ++ Q++
Sbjct: 325 NQRRDFAVVKALAKLKAEDCEISFLPFNSS------------------------DDVQER 360
Query: 368 ALYGLEAAEDVEEWQVVCGKFLAINATNMSCACRRSPRGLSPAAHLGDGSSDLILIRKCS 427
G ++ ++WQ++ G+FL ++ + C C +PRGL+P L +GS LI+ R S
Sbjct: 361 RAQGSPKSDCNDQWQMIQGQFLNVSIMAIPCLCSVAPRGLAPNTRLNNGSMALIIARNTS 420
Query: 428 RFNFLRFLIRHTNQQDQFDFTFVEVYRVKKFQFTSKH-------MEDEDSDLKEGGKKRF 480
R F++ L R+ + ++QF+F FVE Y V++ + ++ E+ED E
Sbjct: 421 RPEFIKHLKRYASVKNQFNFPFVETYTVEEVKVHPRNNTGGYNPEEEEDETASE------ 474
Query: 481 GHICSSHPSCCCTVSNSSWNCDGEVLH-SPAIEVRVHCQLVRLFARGIEE 529
+C WN DG+++ + + +R+H +L+ L+ +EE
Sbjct: 475 --------NC------FPWNVDGDLMEVASEVHIRLHPRLISLYGGSMEE 510
>gi|71896711 ceramide kinase-like isoform d [Homo sapiens]
Length = 463
Score = 116 bits (291), Expect = 5e-26
Identities = 121/530 (22%), Positives = 211/530 (39%), Gaps = 128/530 (24%)
Query: 10 LQSVLWVKQQRCAVSLEPARALLRWWRSPGPGAGAPGADACSVPVSEIIAVEET-DVHGK 68
L+ + + + C V L RAL WR P A + + E I +++ V K
Sbjct: 48 LRGIFEIGRDSCDVVLSE-RALR--WRPIQPERPAGDSKYDLLCKEEFIELKDIFSVKLK 104
Query: 69 HQGSGKWQKMEKPYAFTVHCVKRARRHRWKWAQVTFWCPEEQLCHLWLQTLREMLEKLTS 128
+ S K Q+ T+ + +++ K + + E C +W + +++L +
Sbjct: 105 RRCSVKQQRSGTLLGITLFICLKKEQNKLKNSTLDLINLSEDHCDIWFRQFKKILAGFPN 164
Query: 129 RPKHLLVFINPFGGKGQGKRIYERKVAPLFTLASITTDIIVTEHANQAKETLYEINIDKY 188
RPK L + +NP K + ++Y KV PL LA I TD VT N +L+
Sbjct: 165 RPKSLKILLNPQSHKKEATQVYYEKVEPLLKLAGIKTD--VTRSTNVLAHSLH------- 215
Query: 189 DGIVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHPRAVLVPSSLRIGIIPAGSTDCVCYST 248
G + + LH ++G Q D +ST
Sbjct: 216 ------GVPHVITATLHIIMGHVQ---------------------------LVDVCTFST 242
Query: 249 VGTSDAETSALHIVVGDSLAMDVSSVHHNSTLLRYSVSLLGYGFYGDIIKDSEKKRWLG- 307
G LLR+ S + +GF G + +EK RW+
Sbjct: 243 AG----------------------------KLLRFGFSAM-FGFGGRTLALAEKYRWMSP 273
Query: 308 LARYDFSGLKTFLSHHCYEGTVSFLPAQHTVGSPRDRKPCRAGCFVCRQSKQQLEEEQKK 367
R DF+ +K + +SFLP + ++ Q++
Sbjct: 274 NQRRDFAVVKALAKLKAEDCEISFLPFNSS------------------------DDVQER 309
Query: 368 ALYGLEAAEDVEEWQVVCGKFLAINATNMSCACRRSPRGLSPAAHLGDGSSDLILIRKCS 427
G ++ ++WQ++ G+FL ++ + C C +PRGL+P L +GS LI+ R S
Sbjct: 310 RAQGSPKSDCNDQWQMIQGQFLNVSIMAIPCLCSVAPRGLAPNTRLNNGSMALIIARNTS 369
Query: 428 RFNFLRFLIRHTNQQDQFDFTFVEVYRVKKFQFTSKH-------MEDEDSDLKEGGKKRF 480
R F++ L R+ + ++QF+F FVE Y V++ + ++ E+ED E
Sbjct: 370 RPEFIKHLKRYASVKNQFNFPFVETYTVEEVKVHPRNNTGGYNPEEEEDETASE------ 423
Query: 481 GHICSSHPSCCCTVSNSSWNCDGEVLH-SPAIEVRVHCQLVRLFARGIEE 529
+C WN DG+++ + + +R+H +L+ L+ +EE
Sbjct: 424 --------NC------FPWNVDGDLMEVASEVHIRLHPRLISLYGGSMEE 459
>gi|71896725 ceramide kinase-like isoform c [Homo sapiens]
Length = 419
Score = 113 bits (283), Expect = 4e-25
Identities = 81/303 (26%), Positives = 143/303 (47%), Gaps = 54/303 (17%)
Query: 236 IPAGSTDCVCYSTVGTSDAETSALHIVVGDSLAMDVSSVHHNSTLLRYSVSLLGYGFYGD 295
I AGST+ + +S G T+ LHI++G +DV + LLR+ S + +GF G
Sbjct: 158 ILAGSTNVLAHSLHGVPHVITATLHIIMGHVQLVDVCTFSTAGKLLRFGFSAM-FGFGGR 216
Query: 296 IIKDSEKKRWLGL-ARYDFSGLKTFLSHHCYEGTVSFLPAQHTVGSPRDRKPCRAGCFVC 354
+ +EK RW+ R DF+ +K + +SFLP +
Sbjct: 217 TLALAEKYRWMSPNQRRDFAVVKALAKLKAEDCEISFLPFNSS----------------- 259
Query: 355 RQSKQQLEEEQKKALYGLEAAEDVEEWQVVCGKFLAINATNMSCACRRSPRGLSPAAHLG 414
++ Q++ G ++ ++WQ++ G+FL ++ + C C +PRGL+P L
Sbjct: 260 -------DDVQERRAQGSPKSDCNDQWQMIQGQFLNVSIMAIPCLCSVAPRGLAPNTRLN 312
Query: 415 DGSSDLILIRKCSRFNFLRFLIRHTNQQDQFDFTFVEVYRVKKFQFTSKH-------MED 467
+GS LI+ R SR F++ L R+ + ++QF+F FVE Y V++ + ++ E+
Sbjct: 313 NGSMALIIARNTSRPEFIKHLKRYASVKNQFNFPFVETYTVEEVKVHPRNNTGGYNPEEE 372
Query: 468 EDSDLKEGGKKRFGHICSSHPSCCCTVSNSSWNCDGEVLH-SPAIEVRVHCQLVRLFARG 526
ED E +C WN DG+++ + + +R+H +L+ L+
Sbjct: 373 EDETASE--------------NC------FPWNVDGDLMEVASEVHIRLHPRLISLYGGS 412
Query: 527 IEE 529
+EE
Sbjct: 413 MEE 415
>gi|21361699 sphingosine kinase 2 [Homo sapiens]
Length = 654
Score = 102 bits (255), Expect = 7e-22
Identities = 70/230 (30%), Positives = 114/230 (49%), Gaps = 21/230 (9%)
Query: 121 EMLEKLTSRPKHLLVFINPFGGKGQGKRIYERKVAPLFTLASITTDIIVTEHANQAKETL 180
E+ L RP LL+ +NPFGG+G + + V P+ + A ++ ++I TE N A+E +
Sbjct: 171 EITPDLLPRPPRLLLLVNPFGGRGLAWQWCKNHVLPMISEAGLSFNLIQTERQNHARELV 230
Query: 181 YEINIDKYDGIVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHPRAVLVPSSLRIGIIPAGS 240
+++ ++DGIV V GDG+ EVL+GL+ R + AV +P +GI+P GS
Sbjct: 231 QGLSLSEWDGIVTVSGDGLLHEVLNGLLDR--------PDWEEAVKMP----VGILPCGS 278
Query: 241 TDCVCYS---------TVGTSDAETSALHIVVGDSLAMDVSSVHHNSTLLRYSVSLLGYG 291
+ + + +G +L + G +D+ SV S +S + +G
Sbjct: 279 GNALAGAVNQHGGFEPALGLDLLLNCSLLLCRGGGHPLDLLSVTLASGSRCFSFLSVAWG 338
Query: 292 FYGDIIKDSEKKRWLGLARYDFSGLKTFLSHHCYEGTVSFLPAQHTVGSP 341
F D+ SE+ R LG AR+ + + H Y G +S+LPA SP
Sbjct: 339 FVSDVDIQSERFRALGSARFTLGTVLGLATLHTYRGRLSYLPATVEPASP 388
>gi|217272885 sphingosine kinase 1 isoform 3 [Homo sapiens]
Length = 384
Score = 93.6 bits (231), Expect = 4e-19
Identities = 65/227 (28%), Positives = 108/227 (47%), Gaps = 22/227 (9%)
Query: 129 RPKHLLVFINPFGGKGQGKRIYERKVAPLFTLASITTDIIVTEHANQAKETLYEINIDKY 188
RP +LV +NP GGKG+ +++ V PL A I+ +++TE N A+E + + ++
Sbjct: 13 RPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRW 72
Query: 189 DGIVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHPRAVLVPSSLRIGIIPAGSTDCVC--- 245
D +V + GDG+ EV++GL+ R + + + +PAGS + +
Sbjct: 73 DALVVMSGDGLMHEVVNGLMERPDWETAIQK------------PLCSLPAGSGNALAASL 120
Query: 246 -----YSTVGTSDAETSALHIVVGDSLA-MDVSSVHHNSTLLRYSVSLLGYGFYGDIIKD 299
Y V D T+ ++ L+ M++ S+H S L +SV L +GF D+ +
Sbjct: 121 NHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLE 180
Query: 300 SEKKRWLGLARYDFSGLKTFLSHHCYEGTVSFLPAQHTVGSPRDRKP 346
SEK R LG R+ + Y G +++LP VGS P
Sbjct: 181 SEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGR-VGSKTPASP 226
>gi|217272883 sphingosine kinase 1 isoform 3 [Homo sapiens]
Length = 384
Score = 93.6 bits (231), Expect = 4e-19
Identities = 65/227 (28%), Positives = 108/227 (47%), Gaps = 22/227 (9%)
Query: 129 RPKHLLVFINPFGGKGQGKRIYERKVAPLFTLASITTDIIVTEHANQAKETLYEINIDKY 188
RP +LV +NP GGKG+ +++ V PL A I+ +++TE N A+E + + ++
Sbjct: 13 RPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRW 72
Query: 189 DGIVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHPRAVLVPSSLRIGIIPAGSTDCVC--- 245
D +V + GDG+ EV++GL+ R + + + +PAGS + +
Sbjct: 73 DALVVMSGDGLMHEVVNGLMERPDWETAIQK------------PLCSLPAGSGNALAASL 120
Query: 246 -----YSTVGTSDAETSALHIVVGDSLA-MDVSSVHHNSTLLRYSVSLLGYGFYGDIIKD 299
Y V D T+ ++ L+ M++ S+H S L +SV L +GF D+ +
Sbjct: 121 NHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLE 180
Query: 300 SEKKRWLGLARYDFSGLKTFLSHHCYEGTVSFLPAQHTVGSPRDRKP 346
SEK R LG R+ + Y G +++LP VGS P
Sbjct: 181 SEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGR-VGSKTPASP 226
>gi|21361088 sphingosine kinase 1 isoform 1 [Homo sapiens]
Length = 398
Score = 93.6 bits (231), Expect = 4e-19
Identities = 65/227 (28%), Positives = 108/227 (47%), Gaps = 22/227 (9%)
Query: 129 RPKHLLVFINPFGGKGQGKRIYERKVAPLFTLASITTDIIVTEHANQAKETLYEINIDKY 188
RP +LV +NP GGKG+ +++ V PL A I+ +++TE N A+E + + ++
Sbjct: 27 RPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRW 86
Query: 189 DGIVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHPRAVLVPSSLRIGIIPAGSTDCVC--- 245
D +V + GDG+ EV++GL+ R + + + +PAGS + +
Sbjct: 87 DALVVMSGDGLMHEVVNGLMERPDWETAIQK------------PLCSLPAGSGNALAASL 134
Query: 246 -----YSTVGTSDAETSALHIVVGDSLA-MDVSSVHHNSTLLRYSVSLLGYGFYGDIIKD 299
Y V D T+ ++ L+ M++ S+H S L +SV L +GF D+ +
Sbjct: 135 NHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLE 194
Query: 300 SEKKRWLGLARYDFSGLKTFLSHHCYEGTVSFLPAQHTVGSPRDRKP 346
SEK R LG R+ + Y G +++LP VGS P
Sbjct: 195 SEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGR-VGSKTPASP 240
>gi|217272880 sphingosine kinase 1 isoform 2 [Homo sapiens]
Length = 470
Score = 93.6 bits (231), Expect = 4e-19
Identities = 65/227 (28%), Positives = 108/227 (47%), Gaps = 22/227 (9%)
Query: 129 RPKHLLVFINPFGGKGQGKRIYERKVAPLFTLASITTDIIVTEHANQAKETLYEINIDKY 188
RP +LV +NP GGKG+ +++ V PL A I+ +++TE N A+E + + ++
Sbjct: 99 RPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRW 158
Query: 189 DGIVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHPRAVLVPSSLRIGIIPAGSTDCVC--- 245
D +V + GDG+ EV++GL+ R + + + +PAGS + +
Sbjct: 159 DALVVMSGDGLMHEVVNGLMERPDWETAIQK------------PLCSLPAGSGNALAASL 206
Query: 246 -----YSTVGTSDAETSALHIVVGDSLA-MDVSSVHHNSTLLRYSVSLLGYGFYGDIIKD 299
Y V D T+ ++ L+ M++ S+H S L +SV L +GF D+ +
Sbjct: 207 NHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLE 266
Query: 300 SEKKRWLGLARYDFSGLKTFLSHHCYEGTVSFLPAQHTVGSPRDRKP 346
SEK R LG R+ + Y G +++LP VGS P
Sbjct: 267 SEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGR-VGSKTPASP 312
>gi|8922701 acylglycerol kinase [Homo sapiens]
Length = 422
Score = 71.6 bits (174), Expect = 2e-12
Identities = 58/223 (26%), Positives = 105/223 (47%), Gaps = 26/223 (11%)
Query: 131 KHLLVFINPFGGKGQGKRIYERKVAPLFTLASITTDIIVTEHANQAKETLYEINIDKYDG 190
K VF+NP KG+ + ++E+ AP+ L+ + I+ T++ QAK+ L E+ ++ D
Sbjct: 61 KKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKK-LLEL-MENTDV 118
Query: 191 IVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHPRAVLVPSSLRIGIIPAGSTDCVCYSTVG 250
I+ GGDG EV+ G++ RT + S + IG IP G T + ++
Sbjct: 119 IIVAGGDGTLQEVVTGVLRRTDEATF------------SKIPIGFIPLGETSSLSHTLFA 166
Query: 251 TSDAET-----SALHIVVGDSLAMDVSSVHHNSTLLRYSVSLLGYGFYGDIIKDSEKKRW 305
S + + L IV G+++ +DV + ++++ L +G + D K +
Sbjct: 167 ESGNKVQHITDATLAIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWY 226
Query: 306 LG----LARYDFSGLKTFLSHHCYEGTVSFL-PAQHTVGSPRD 343
LG A + FS LK + H + ++S+ P + P +
Sbjct: 227 LGPLKIKAAHFFSTLKEWPQTH--QASISYTGPTERPPNEPEE 267
>gi|189027129 phosphodiesterase 12 [Homo sapiens]
Length = 609
Score = 30.0 bits (66), Expect = 5.6
Identities = 16/42 (38%), Positives = 22/42 (52%), Gaps = 2/42 (4%)
Query: 26 EPARALLRWWRSPGPGAGAP--GADACSVPVSEIIAVEETDV 65
+PA +L RW++ PGA P G + P S + ETDV
Sbjct: 189 DPASSLFRWYKEAKPGAAEPEVGVPSSLSPSSPSSSWTETDV 230
>gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens]
Length = 1590
Score = 29.6 bits (65), Expect = 7.3
Identities = 15/52 (28%), Positives = 25/52 (48%), Gaps = 10/52 (19%)
Query: 490 CCCTVSNSSWNCDGEVLHSPAIEV----------RVHCQLVRLFARGIEENP 531
C C+ S SS++C +P I + +C +VR+F +G +E P
Sbjct: 905 CACSPSFSSYDCSDSYDKAPEITELGNAGFCDVQKYNCMMVRVFGKGFKELP 956
>gi|46255064 synaptotagmin-like 2 isoform d [Homo sapiens]
Length = 1256
Score = 29.3 bits (64), Expect = 9.5
Identities = 32/121 (26%), Positives = 48/121 (39%), Gaps = 18/121 (14%)
Query: 118 TLREMLEKLTSRPKHLLVFINPFGGKGQGKRIYERKVAPLFTLASITTDIIVTEHANQAK 177
T + L+KL S I P GGK GK++ E V+ T TD TE +
Sbjct: 164 TFNDSLQKLLSETS--TPAIQPSGGKVHGKQVLEPSVSENRTWPQ-KTDFADTEEEVKGP 220
Query: 178 ETLYEINIDKYDGIVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHPRAV-LVPSSLRIGII 236
E + ++DK V+H + R +A +D+ A PS L+ +
Sbjct: 221 EKIINEHVDK--------------TVVHPKVKRNSLTASLDKLLKEATGTSPSPLQAKLA 266
Query: 237 P 237
P
Sbjct: 267 P 267
>gi|46255062 synaptotagmin-like 2 isoform c [Homo sapiens]
Length = 1272
Score = 29.3 bits (64), Expect = 9.5
Identities = 32/121 (26%), Positives = 48/121 (39%), Gaps = 18/121 (14%)
Query: 118 TLREMLEKLTSRPKHLLVFINPFGGKGQGKRIYERKVAPLFTLASITTDIIVTEHANQAK 177
T + L+KL S I P GGK GK++ E V+ T TD TE +
Sbjct: 164 TFNDSLQKLLSETS--TPAIQPSGGKVHGKQVLEPSVSENRTWPQ-KTDFADTEEEVKGP 220
Query: 178 ETLYEINIDKYDGIVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHPRAV-LVPSSLRIGII 236
E + ++DK V+H + R +A +D+ A PS L+ +
Sbjct: 221 EKIINEHVDK--------------TVVHPKVKRNSLTASLDKLLKEATGTSPSPLQAKLA 266
Query: 237 P 237
P
Sbjct: 267 P 267
>gi|95147335 inositol 1,4,5-triphosphate receptor, type 2 [Homo
sapiens]
Length = 2701
Score = 29.3 bits (64), Expect = 9.5
Identities = 15/21 (71%), Positives = 16/21 (76%)
Query: 108 EEQLCHLWLQTLREMLEKLTS 128
EE+LC LQTLREMLEK S
Sbjct: 1667 EEKLCIKILQTLREMLEKKDS 1687
>gi|4826988 ribosomal protein L3-like [Homo sapiens]
Length = 407
Score = 29.3 bits (64), Expect = 9.5
Identities = 25/116 (21%), Positives = 49/116 (42%), Gaps = 15/116 (12%)
Query: 346 PCRAGCFVCRQSKQQLEE--EQKKALYGLEAAEDVEEWQVVCGKFLAINATNMSCACRRS 403
P R GC + R ++ E K ++ + +E+ GK + NA+ +S
Sbjct: 259 PARVGCSIARAGQKGYHHRTELNKKIFRIGRGPHMED-----GKLVKNNASTSYDVTAKS 313
Query: 404 PRGLSPAAHLGDGSSDLILIRKC-----SRFNFLR--FLIRHTNQQ-DQFDFTFVE 451
L H G+ ++D ++++ C R LR L+ H+ Q + + F++
Sbjct: 314 ITPLGGFPHYGEVNNDFVMLKGCIAGTKKRVITLRKSLLVHHSRQAVENIELKFID 369
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.430
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,903,940
Number of Sequences: 37866
Number of extensions: 1114345
Number of successful extensions: 2646
Number of sequences better than 10.0: 18
Number of HSP's better than 10.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 2616
Number of HSP's gapped (non-prelim): 19
length of query: 537
length of database: 18,247,518
effective HSP length: 107
effective length of query: 430
effective length of database: 14,195,856
effective search space: 6104218080
effective search space used: 6104218080
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.