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Search of human proteins with 197245437
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|197245437 eukaryotic translation initiation factor 2-alpha
kinase 1 isoform b [Homo sapiens]
(629 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|197245437 eukaryotic translation initiation factor 2-alpha ki... 1253 0.0
gi|11125768 eukaryotic translation initiation factor 2-alpha kin... 1248 0.0
gi|65287717 eukaryotic translation initiation factor 2 alpha kin... 167 2e-41
gi|134304838 eukaryotic translation initiation factor 2-alpha ki... 134 2e-31
gi|208431829 eukaryotic translation initiation factor 2-alpha ki... 106 6e-23
gi|208431827 eukaryotic translation initiation factor 2-alpha ki... 103 4e-22
gi|4506103 eukaryotic translation initiation factor 2-alpha kina... 103 4e-22
gi|4826878 oxidative-stress responsive 1 [Homo sapiens] 81 3e-15
gi|4505373 NIMA-related kinase 2 [Homo sapiens] 80 4e-15
gi|115430252 serine threonine kinase 39 (STE20/SPS1 homolog, yea... 79 1e-14
gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens] 76 8e-14
gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens] 76 8e-14
gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens] 76 8e-14
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 75 1e-13
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 75 1e-13
gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo sa... 75 1e-13
gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo sa... 75 1e-13
gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinas... 74 3e-13
gi|148612809 WNK lysine deficient protein kinase 1 [Homo sapiens] 73 7e-13
gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Hom... 73 9e-13
gi|33188459 B-Raf [Homo sapiens] 72 2e-12
gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens] 71 3e-12
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 71 3e-12
gi|50845418 WNK lysine deficient protein kinase 3 isoform 1 [Hom... 70 4e-12
gi|50845416 WNK lysine deficient protein kinase 3 isoform 2 [Hom... 70 4e-12
gi|109633028 serine/threonine protein kinase MST4 isoform 2 [Hom... 70 4e-12
gi|156105707 SNF related kinase [Homo sapiens] 69 1e-11
gi|156105705 SNF related kinase [Homo sapiens] 69 1e-11
gi|21359873 polo-like kinase 1 [Homo sapiens] 69 1e-11
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 69 2e-11
>gi|197245437 eukaryotic translation initiation factor 2-alpha
kinase 1 isoform b [Homo sapiens]
Length = 629
Score = 1253 bits (3242), Expect = 0.0
Identities = 629/629 (100%), Positives = 629/629 (100%)
Query: 1 MQGGNSGVRKREEEGDGAGAVAAPPAIDFPAEGPDPEYDESDVPAEIQVLKEPLQQPTFP 60
MQGGNSGVRKREEEGDGAGAVAAPPAIDFPAEGPDPEYDESDVPAEIQVLKEPLQQPTFP
Sbjct: 1 MQGGNSGVRKREEEGDGAGAVAAPPAIDFPAEGPDPEYDESDVPAEIQVLKEPLQQPTFP 60
Query: 61 FAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHH 120
FAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHH
Sbjct: 61 FAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHH 120
Query: 121 NRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGR 180
NRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGR
Sbjct: 121 NRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGR 180
Query: 181 VYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVI 240
VYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVI
Sbjct: 181 VYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVI 240
Query: 241 QPRDRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQN 300
QPRDRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQN
Sbjct: 241 QPRDRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQN 300
Query: 301 NKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEES 360
NKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEES
Sbjct: 301 NKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEES 360
Query: 361 SEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVATK 420
SEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVATK
Sbjct: 361 SEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVATK 420
Query: 421 IFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNG 480
IFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNG
Sbjct: 421 IFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNG 480
Query: 481 KRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLR 540
KRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLR
Sbjct: 481 KRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLR 540
Query: 541 TGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQE 600
TGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQE
Sbjct: 541 TGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQE 600
Query: 601 KEIAELKKQLNLLSQDKGVRDDGKDGGVG 629
KEIAELKKQLNLLSQDKGVRDDGKDGGVG
Sbjct: 601 KEIAELKKQLNLLSQDKGVRDDGKDGGVG 629
>gi|11125768 eukaryotic translation initiation factor 2-alpha kinase
1 isoform a [Homo sapiens]
Length = 630
Score = 1248 bits (3230), Expect = 0.0
Identities = 629/630 (99%), Positives = 629/630 (99%), Gaps = 1/630 (0%)
Query: 1 MQGGNSGVRKREEEGDGAGAVAAPPAIDFPAEGPDPEYDESDVPAEIQVLKEPLQQPTFP 60
MQGGNSGVRKREEEGDGAGAVAAPPAIDFPAEGPDPEYDESDVPAEIQVLKEPLQQPTFP
Sbjct: 1 MQGGNSGVRKREEEGDGAGAVAAPPAIDFPAEGPDPEYDESDVPAEIQVLKEPLQQPTFP 60
Query: 61 FAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHH 120
FAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHH
Sbjct: 61 FAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHH 120
Query: 121 NRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGR 180
NRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGR
Sbjct: 121 NRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGR 180
Query: 181 VYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVI 240
VYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVI
Sbjct: 181 VYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVI 240
Query: 241 QPR-DRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQ 299
QPR DRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQ
Sbjct: 241 QPRADRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQ 300
Query: 300 NNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEE 359
NNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEE
Sbjct: 301 NNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEE 360
Query: 360 SSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVAT 419
SSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVAT
Sbjct: 361 SSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVAT 420
Query: 420 KIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRN 479
KIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRN
Sbjct: 421 KIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRN 480
Query: 480 GKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGL 539
GKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGL
Sbjct: 481 GKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGL 540
Query: 540 RTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQ 599
RTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQ
Sbjct: 541 RTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQ 600
Query: 600 EKEIAELKKQLNLLSQDKGVRDDGKDGGVG 629
EKEIAELKKQLNLLSQDKGVRDDGKDGGVG
Sbjct: 601 EKEIAELKKQLNLLSQDKGVRDDGKDGGVG 630
>gi|65287717 eukaryotic translation initiation factor 2 alpha kinase 4
[Homo sapiens]
Length = 1649
Score = 167 bits (424), Expect = 2e-41
Identities = 158/476 (33%), Positives = 228/476 (47%), Gaps = 48/476 (10%)
Query: 129 RSAKERVRQDPCEDISRIQKIRSREVALEAQT--SRYLNEFEELAILGKGGYGRVYKVRN 186
+S ++ QD E + ++ S E Q SRY EFEEL +LGKG +G V KV+N
Sbjct: 550 QSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGAFGAVIKVQN 609
Query: 187 KLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVIQPRDRA 246
KLDG YA+K+I I A++ ++ EV +L+ L H NIV Y+ AWIE +P
Sbjct: 610 KLDGCCYAVKRIPINPASRQF-RRIKGEVTLLSRLHHENIVRYYNAWIERHE--RPAGPG 666
Query: 247 AIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQNNKSVKY 306
S + D R Q +D S+ A P P E T + + S ++
Sbjct: 667 TPPPDSGPLAKDDRAARGQ--PASDTDGLDSVEAAAPPPILSSSV-EWSTSGERSASARF 723
Query: 307 TTNLVIRESGELESTLELQENGLAGLS--ASSIVEQQLPLRRNSHLEESFTSTEESSEEN 364
S + E E + G+ S +S E + +S E+ +E+N
Sbjct: 724 PA--TGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEKN 781
Query: 365 VNFLGQ----TEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVATK 420
+ TEA ++ L+IQM+ CE S R+ +D+ Y +
Sbjct: 782 GCHESEPSVTTEAVHY--LYIQMEYCEKSTL----------RDTIDQGL--YRDTVRLWR 827
Query: 421 IFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDIL-----QKNTDW 475
+F+E+++G+ YIH G++HRDLKP NIFL D VKIGDFGLA TD L K D
Sbjct: 828 LFREILDGLAYIHEKGMIHRDLKPVNIFLDS-DDHVKIGDFGLA-TDHLAFSADSKQDDQ 885
Query: 476 TNRNGKRTPTH--TSRVGTCLYASPEQLEG---SEYDAKSDMYSLGVVLLEL-FQPFGTE 529
T K P+ T VGT LY SPE ++G S Y+ K D++SLG++ E+ + P T
Sbjct: 886 TGDLIKSDPSGHLTGMVGTALYVSPE-VQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTA 944
Query: 530 MERAEVLTGLR---TGQLPESLRK-RCPVQAKYIQHLTRRNSSQRPSAIQLLQSEL 581
ER VL LR + + PE Q I L + ++RP+A +LL+SEL
Sbjct: 945 SERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSEL 1000
Score = 33.1 bits (74), Expect = 0.79
Identities = 41/185 (22%), Positives = 78/185 (42%), Gaps = 39/185 (21%)
Query: 424 ELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLA--CTDILQKNTDWTNRNGK 481
+L+ G+ Y+H+ +VH+ L N+ + + VKI D+ ++ DI +++
Sbjct: 408 QLLSGLDYLHSNSVVHKVLSASNVLVDA-EGTVKITDYSISKRLADICKEDV-------- 458
Query: 482 RTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLRT 541
+RV A P + K D++ LG++LL L Q G
Sbjct: 459 ---FEQTRVRFSDNALPYKT-----GKKGDVWRLGLLLLSLSQ-------------GQEC 497
Query: 542 GQLPESLRKRCPVQAK-YIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQE 600
G+ P ++ P + +++ + +R S QLL+ +N +M ++EQ
Sbjct: 498 GEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSF------INPQPKMPLVEQS 551
Query: 601 KEIAE 605
E +E
Sbjct: 552 PEDSE 556
>gi|134304838 eukaryotic translation initiation factor 2-alpha kinase
3 [Homo sapiens]
Length = 1116
Score = 134 bits (338), Expect = 2e-31
Identities = 96/324 (29%), Positives = 151/324 (46%), Gaps = 32/324 (9%)
Query: 270 NDESSSSSIIFAEPTPEKEKR--------FGESDTENQNNKSVKYTTNLVIRESGELEST 321
NDE S + +E +P R F +S +N ++K T L I + T
Sbjct: 779 NDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLT 838
Query: 322 LELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEESSEENVNFLGQTEAQYHLMLHI 381
+ + A+ + P + L ++ T + S V L+I
Sbjct: 839 AFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKV------------YLYI 886
Query: 382 QMQLCEL-SLWDWIVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHR 440
QMQLC +L DW+ GR ++E +V IF ++ E V ++H+ G++HR
Sbjct: 887 QMQLCRKENLKDWM-----NGRCTIEERE-----RSVCLHIFLQIAEAVEFLHSKGLMHR 936
Query: 441 DLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRVGTCLYASPEQ 500
DLKP NIF D VK+GDFGL + HT +VGT LY SPEQ
Sbjct: 937 DLKPSNIFFT-MDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQ 995
Query: 501 LEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQ 560
+ G+ Y K D++SLG++L EL PF T+MER LT +R + P ++ P + +Q
Sbjct: 996 IHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQ 1055
Query: 561 HLTRRNSSQRPSAIQLLQSELFQN 584
+ + +RP AI ++++ +F++
Sbjct: 1056 DMLSPSPMERPEAINIIENAVFED 1079
Score = 74.7 bits (182), Expect = 2e-13
Identities = 37/75 (49%), Positives = 51/75 (68%), Gaps = 1/75 (1%)
Query: 161 SRYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAG 220
SRYL +FE + LG+GG+G V++ +NK+D YAIK+I + + KV+REVK LA
Sbjct: 587 SRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPN-RELAREKVMREVKALAK 645
Query: 221 LQHPNIVGYHTAWIE 235
L+HP IV Y AW+E
Sbjct: 646 LEHPGIVRYFNAWLE 660
>gi|208431829 eukaryotic translation initiation factor 2-alpha
kinase 2 isoform b [Homo sapiens]
Length = 510
Score = 106 bits (265), Expect = 6e-23
Identities = 92/325 (28%), Positives = 148/325 (45%), Gaps = 40/325 (12%)
Query: 258 DQEEDREQCGVKNDESSSSSIIF--AEPTPEKEKRFGESDTENQNNKSVKYTTNLVIRES 315
D D + +D +SSS++ K KR + + K KYT +
Sbjct: 207 DFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAKRSLAPRFDLPDMKETKYTVD------ 260
Query: 316 GELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEESSEENVNFLGQTEAQY 375
+ E + LA L +IV + E+ + ESS+ + +
Sbjct: 261 ---KRKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSK 317
Query: 376 HLMLHIQMQLCEL-SLWDWIVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHN 434
L IQM+ C+ +L WI KR E +D+ +A ++F+++ +GV YIH+
Sbjct: 318 TKCLFIQMEFCDKGTLEQWI---EKRRGEKLDKV--------LALELFEQITKGVDYIHS 366
Query: 435 MGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRVGTCL 494
++HRDLKP NIFL +QVKIGDFGL + +GKRT + GT
Sbjct: 367 KKLIHRDLKPSNIFLVDT-KQVKIGDFGLVTS---------LKNDGKRTRSK----GTLR 412
Query: 495 YASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLRTGQLPESLRKRCPV 554
Y SPEQ+ +Y + D+Y+LG++L EL T E ++ T LR G + + K+
Sbjct: 413 YMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKK--- 469
Query: 555 QAKYIQHLTRRNSSQRPSAIQLLQS 579
+ +Q L + RP+ ++L++
Sbjct: 470 EKTLLQKLLSKKPEDRPNTSEILRT 494
Score = 30.0 bits (66), Expect = 6.7
Identities = 14/24 (58%), Positives = 15/24 (62%)
Query: 210 KVLREVKVLAGLQHPNIVGYHTAW 233
K REVK LA L H NIV Y+ W
Sbjct: 263 KAEREVKALAKLDHVNIVHYNGCW 286
>gi|208431827 eukaryotic translation initiation factor 2-alpha
kinase 2 isoform a [Homo sapiens]
Length = 551
Score = 103 bits (258), Expect = 4e-22
Identities = 75/230 (32%), Positives = 118/230 (51%), Gaps = 30/230 (13%)
Query: 351 EESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCEL-SLWDWIVERNKRGREYVDESA 409
E S S E S + N + ++ L IQM+ C+ +L WI KR E +D+
Sbjct: 335 ETSDDSLESSDYDPENSKNSSRSKTKC-LFIQMEFCDKGTLEQWI---EKRRGEKLDKV- 389
Query: 410 CPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDIL 469
+A ++F+++ +GV YIH+ ++HRDLKP NIFL +QVKIGDFGL +
Sbjct: 390 -------LALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDT-KQVKIGDFGLVTS--- 438
Query: 470 QKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTE 529
+GKRT + GT Y SPEQ+ +Y + D+Y+LG++L EL T
Sbjct: 439 ------LKNDGKRTRSK----GTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTA 488
Query: 530 MERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQS 579
E ++ T LR G + + K+ + +Q L + RP+ ++L++
Sbjct: 489 FETSKFFTDLRDGIISDIFDKK---EKTLLQKLLSKKPEDRPNTSEILRT 535
Score = 60.5 bits (145), Expect = 5e-09
Identities = 28/72 (38%), Positives = 45/72 (62%), Gaps = 6/72 (8%)
Query: 162 RYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGL 221
R+ +F+E+ ++G GG+G+V+K ++++DG+ Y IK++ K REVK LA L
Sbjct: 262 RFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNE------KAEREVKALAKL 315
Query: 222 QHPNIVGYHTAW 233
H NIV Y+ W
Sbjct: 316 DHVNIVHYNGCW 327
>gi|4506103 eukaryotic translation initiation factor 2-alpha kinase
2 isoform a [Homo sapiens]
Length = 551
Score = 103 bits (258), Expect = 4e-22
Identities = 75/230 (32%), Positives = 118/230 (51%), Gaps = 30/230 (13%)
Query: 351 EESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCEL-SLWDWIVERNKRGREYVDESA 409
E S S E S + N + ++ L IQM+ C+ +L WI KR E +D+
Sbjct: 335 ETSDDSLESSDYDPENSKNSSRSKTKC-LFIQMEFCDKGTLEQWI---EKRRGEKLDKV- 389
Query: 410 CPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDIL 469
+A ++F+++ +GV YIH+ ++HRDLKP NIFL +QVKIGDFGL +
Sbjct: 390 -------LALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDT-KQVKIGDFGLVTS--- 438
Query: 470 QKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTE 529
+GKRT + GT Y SPEQ+ +Y + D+Y+LG++L EL T
Sbjct: 439 ------LKNDGKRTRSK----GTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTA 488
Query: 530 MERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQS 579
E ++ T LR G + + K+ + +Q L + RP+ ++L++
Sbjct: 489 FETSKFFTDLRDGIISDIFDKK---EKTLLQKLLSKKPEDRPNTSEILRT 535
Score = 60.5 bits (145), Expect = 5e-09
Identities = 28/72 (38%), Positives = 45/72 (62%), Gaps = 6/72 (8%)
Query: 162 RYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGL 221
R+ +F+E+ ++G GG+G+V+K ++++DG+ Y IK++ K REVK LA L
Sbjct: 262 RFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNE------KAEREVKALAKL 315
Query: 222 QHPNIVGYHTAW 233
H NIV Y+ W
Sbjct: 316 DHVNIVHYNGCW 327
>gi|4826878 oxidative-stress responsive 1 [Homo sapiens]
Length = 527
Score = 81.3 bits (199), Expect = 3e-15
Identities = 75/246 (30%), Positives = 119/246 (48%), Gaps = 29/246 (11%)
Query: 394 IVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPD 453
IV + + +DES +AT I +E++EG+ Y+H G +HRD+K NI L G D
Sbjct: 107 IVAKGEHKSGVLDEST-------IAT-ILREVLEGLEYLHKNGQIHRDVKAGNILL-GED 157
Query: 454 QQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLEGSE-YDAKSDM 512
V+I DFG++ L D T ++T VGT + +PE +E YD K+D+
Sbjct: 158 GSVQIADFGVSA--FLATGGDITRNKVRKT-----FVGTPCWMAPEVMEQVRGYDFKADI 210
Query: 513 YSLGVVLLEL---------FQPFGTEMERAE-VLTGLRTG-QLPESLRKRCPVQAKYIQH 561
+S G+ +EL + P M + L TG Q E L+K K I
Sbjct: 211 WSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISL 270
Query: 562 LTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQEKEIAELKKQLNLLSQDKGVRD 621
+++ +RP+A +LL+ + FQ + N LQ K +++ I+E K++ + G
Sbjct: 271 CLQKDPEKRPTAAELLRHKFFQKAKNKEF-LQEKTLQRAPTISERAKKVRRVPGSSGRLH 329
Query: 622 DGKDGG 627
+DGG
Sbjct: 330 KTEDGG 335
Score = 33.9 bits (76), Expect = 0.47
Identities = 18/70 (25%), Positives = 39/70 (55%), Gaps = 1/70 (1%)
Query: 165 NEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHP 224
+++E ++G G V + AIK+I ++ +T ++L+E++ ++ HP
Sbjct: 15 DDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKC-QTSMDELLKEIQAMSQCHHP 73
Query: 225 NIVGYHTAWI 234
NIV Y+T+++
Sbjct: 74 NIVSYYTSFV 83
>gi|4505373 NIMA-related kinase 2 [Homo sapiens]
Length = 445
Score = 80.5 bits (197), Expect = 4e-15
Identities = 65/207 (31%), Positives = 98/207 (47%), Gaps = 22/207 (10%)
Query: 379 LHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANV--ATKIFQELVEGVFYIHNMG 436
L+I M+ CE ++ + + R+Y+DE VM + A K +G
Sbjct: 82 LYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDG-----GHT 136
Query: 437 IVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRVGTCLYA 496
++HRDLKP N+FL G Q VK+GDFGLA IL +T + + VGT Y
Sbjct: 137 VLHRDLKPANVFLDGK-QNVKLGDFGLA--RILNHDTSFAK----------TFVGTPYYM 183
Query: 497 SPEQLEGSEYDAKSDMYSLGVVLLEL--FQPFGTEMERAEVLTGLRTGQLPESLRKRCPV 554
SPEQ+ Y+ KSD++SLG +L EL P T + E+ +R G+ +
Sbjct: 184 SPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDE 243
Query: 555 QAKYIQHLTRRNSSQRPSAIQLLQSEL 581
+ I + RPS ++L++ L
Sbjct: 244 LNEIITRMLNLKDYHRPSVEEILENPL 270
Score = 49.7 bits (117), Expect = 8e-06
Identities = 25/73 (34%), Positives = 40/73 (54%)
Query: 166 EFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPN 225
++E L +G G YGR K+R K DG+ K++ T+ ++ EV +L L+HPN
Sbjct: 7 DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPN 66
Query: 226 IVGYHTAWIEHVH 238
IV Y+ I+ +
Sbjct: 67 IVRYYDRIIDRTN 79
>gi|115430252 serine threonine kinase 39 (STE20/SPS1 homolog, yeast)
[Homo sapiens]
Length = 545
Score = 79.3 bits (194), Expect = 1e-14
Identities = 70/251 (27%), Positives = 121/251 (48%), Gaps = 29/251 (11%)
Query: 388 LSLWDWIVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNI 447
L + +IV R + ++E+ + I +E++EG+ Y+H G +HRDLK NI
Sbjct: 147 LDIIKYIVNRGEHKNGVLEEA--------IIATILKEVLEGLDYLHRNGQIHRDLKAGNI 198
Query: 448 FLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLEGSE-Y 506
L G D V+I DFG++ L D T ++T VGT + +PE +E Y
Sbjct: 199 LL-GEDGSVQIADFGVSA--FLATGGDVTRNKVRKT-----FVGTPCWMAPEVMEQVRGY 250
Query: 507 DAKSDMYSLGVVLLEL---------FQPFGTEMERAE-VLTGLRTG-QLPESLRKRCPVQ 555
D K+DM+S G+ +EL + P M + L TG + E ++K
Sbjct: 251 DFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSF 310
Query: 556 AKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQEKEIAELKKQLNLLSQ 615
K + +++ S+RP+A +LL+ + FQ + N ++ K++ + +IA+ K++ +
Sbjct: 311 RKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIE-KLLTRTPDIAQRAKKVRRVPG 369
Query: 616 DKGVRDDGKDG 626
G +DG
Sbjct: 370 SSGHLHKTEDG 380
Score = 33.5 bits (75), Expect = 0.61
Identities = 18/68 (26%), Positives = 38/68 (55%), Gaps = 1/68 (1%)
Query: 167 FEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNI 226
+E ++G G V K + AIK+I ++ +T ++L+E++ ++ HPN+
Sbjct: 63 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKC-QTSMDELLKEIQAMSQCSHPNV 121
Query: 227 VGYHTAWI 234
V Y+T+++
Sbjct: 122 VTYYTSFV 129
>gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens]
Length = 470
Score = 76.3 bits (186), Expect = 8e-14
Identities = 64/194 (32%), Positives = 99/194 (51%), Gaps = 24/194 (12%)
Query: 422 FQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGK 481
F +L+ GV Y+H I+HRDLK +N+FL + +KIGDFG++ +L + D
Sbjct: 139 FIQLLLGVDYMHERRILHRDLKSKNVFLK--NNLLKIGDFGVS--RLLMGSCDLA----- 189
Query: 482 RTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLEL--FQPFGTEMERAEVLTGL 539
T+ GT Y SPE L+ YD KSD++SL +L E+ ++ +
Sbjct: 190 -----TTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKI 244
Query: 540 RTGQLPESLRKRCPVQAKYI-QHLTRRNSSQRPSAIQLLQ----SELFQN--SGNVNLTL 592
G P SL +R P + I + + +N S RPSAI++L+ E QN +TL
Sbjct: 245 VEGDTP-SLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTL 303
Query: 593 QMKIIEQEKEIAEL 606
+ K ++ +KE A +
Sbjct: 304 EDKNLDCQKEAAHI 317
Score = 34.3 bits (77), Expect = 0.36
Identities = 19/66 (28%), Positives = 34/66 (51%), Gaps = 3/66 (4%)
Query: 173 LGKGGYGRVYKVRNKL---DGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGY 229
LG G +G VY V +K + +K+I + ++ E ++L+ L HP IV +
Sbjct: 35 LGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKF 94
Query: 230 HTAWIE 235
H +++E
Sbjct: 95 HASFVE 100
>gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens]
Length = 599
Score = 76.3 bits (186), Expect = 8e-14
Identities = 64/194 (32%), Positives = 99/194 (51%), Gaps = 24/194 (12%)
Query: 422 FQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGK 481
F +L+ GV Y+H I+HRDLK +N+FL + +KIGDFG++ +L + D
Sbjct: 139 FIQLLLGVDYMHERRILHRDLKSKNVFLK--NNLLKIGDFGVS--RLLMGSCDLA----- 189
Query: 482 RTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLEL--FQPFGTEMERAEVLTGL 539
T+ GT Y SPE L+ YD KSD++SL +L E+ ++ +
Sbjct: 190 -----TTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKI 244
Query: 540 RTGQLPESLRKRCPVQAKYI-QHLTRRNSSQRPSAIQLLQ----SELFQN--SGNVNLTL 592
G P SL +R P + I + + +N S RPSAI++L+ E QN +TL
Sbjct: 245 VEGDTP-SLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTL 303
Query: 593 QMKIIEQEKEIAEL 606
+ K ++ +KE A +
Sbjct: 304 EDKNLDCQKEAAHI 317
Score = 34.3 bits (77), Expect = 0.36
Identities = 19/66 (28%), Positives = 34/66 (51%), Gaps = 3/66 (4%)
Query: 173 LGKGGYGRVYKVRNKL---DGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGY 229
LG G +G VY V +K + +K+I + ++ E ++L+ L HP IV +
Sbjct: 35 LGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKF 94
Query: 230 HTAWIE 235
H +++E
Sbjct: 95 HASFVE 100
>gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens]
Length = 645
Score = 76.3 bits (186), Expect = 8e-14
Identities = 64/194 (32%), Positives = 99/194 (51%), Gaps = 24/194 (12%)
Query: 422 FQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGK 481
F +L+ GV Y+H I+HRDLK +N+FL + +KIGDFG++ +L + D
Sbjct: 139 FIQLLLGVDYMHERRILHRDLKSKNVFLK--NNLLKIGDFGVS--RLLMGSCDLA----- 189
Query: 482 RTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLEL--FQPFGTEMERAEVLTGL 539
T+ GT Y SPE L+ YD KSD++SL +L E+ ++ +
Sbjct: 190 -----TTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKI 244
Query: 540 RTGQLPESLRKRCPVQAKYI-QHLTRRNSSQRPSAIQLLQ----SELFQN--SGNVNLTL 592
G P SL +R P + I + + +N S RPSAI++L+ E QN +TL
Sbjct: 245 VEGDTP-SLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTL 303
Query: 593 QMKIIEQEKEIAEL 606
+ K ++ +KE A +
Sbjct: 304 EDKNLDCQKEAAHI 317
Score = 34.3 bits (77), Expect = 0.36
Identities = 19/66 (28%), Positives = 34/66 (51%), Gaps = 3/66 (4%)
Query: 173 LGKGGYGRVYKVRNKL---DGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGY 229
LG G +G VY V +K + +K+I + ++ E ++L+ L HP IV +
Sbjct: 35 LGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKF 94
Query: 230 HTAWIE 235
H +++E
Sbjct: 95 HASFVE 100
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 75.5 bits (184), Expect = 1e-13
Identities = 74/286 (25%), Positives = 133/286 (46%), Gaps = 32/286 (11%)
Query: 350 LEESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDE-S 408
LEE+ E+ +E + L Q ++ Y + + L + LW I+ G +D
Sbjct: 57 LEEAEDEIEDIQQE-ITVLSQCDSPY-VTKYYGSYLKDTKLW--IIMEYLGGGSALDLLE 112
Query: 409 ACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFL--HGPDQQVKIGDFGLACT 466
P +AT I +E+++G+ Y+H+ +HRD+K N+ L HG +VK+ DFG+A
Sbjct: 113 PGPLDETQIAT-ILREILKGLDYLHSEKKIHRDIKAANVLLSEHG---EVKLADFGVA-- 166
Query: 467 DILQKNTDWTNRNGKRTPTHTSR---VGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF 523
G+ T T R VGT + +PE ++ S YD+K+D++SLG+ +EL
Sbjct: 167 -------------GQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELA 213
Query: 524 --QPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSEL 581
+P +E+ +VL + P ++++ + S RP+A +LL+ +
Sbjct: 214 RGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKF 273
Query: 582 FQNSGNVNLTLQMKIIEQEKEIAELKKQLNLLSQDKGVRDDGKDGG 627
+ L ++I++ K + + S+D DG+ G
Sbjct: 274 ILRNAKKTSYL-TELIDRYKRWKAEQSHDDSSSEDSDAETDGQASG 318
Score = 30.8 bits (68), Expect = 3.9
Identities = 18/69 (26%), Positives = 37/69 (53%), Gaps = 1/69 (1%)
Query: 167 FEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNI 226
F +L +GKG +G V+K + + AIK I ++ A + + +E+ VL+ P +
Sbjct: 24 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEI-EDIQQEITVLSQCDSPYV 82
Query: 227 VGYHTAWIE 235
Y+ ++++
Sbjct: 83 TKYYGSYLK 91
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 75.5 bits (184), Expect = 1e-13
Identities = 74/286 (25%), Positives = 133/286 (46%), Gaps = 32/286 (11%)
Query: 350 LEESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDE-S 408
LEE+ E+ +E + L Q ++ Y + + L + LW I+ G +D
Sbjct: 69 LEEAEDEIEDIQQE-ITVLSQCDSPY-VTKYYGSYLKDTKLW--IIMEYLGGGSALDLLE 124
Query: 409 ACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFL--HGPDQQVKIGDFGLACT 466
P +AT I +E+++G+ Y+H+ +HRD+K N+ L HG +VK+ DFG+A
Sbjct: 125 PGPLDETQIAT-ILREILKGLDYLHSEKKIHRDIKAANVLLSEHG---EVKLADFGVA-- 178
Query: 467 DILQKNTDWTNRNGKRTPTHTSR---VGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF 523
G+ T T R VGT + +PE ++ S YD+K+D++SLG+ +EL
Sbjct: 179 -------------GQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELA 225
Query: 524 --QPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSEL 581
+P +E+ +VL + P ++++ + S RP+A +LL+ +
Sbjct: 226 RGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKF 285
Query: 582 FQNSGNVNLTLQMKIIEQEKEIAELKKQLNLLSQDKGVRDDGKDGG 627
+ L ++I++ K + + S+D DG+ G
Sbjct: 286 ILRNAKKTSYL-TELIDRYKRWKAEQSHDDSSSEDSDAETDGQASG 330
Score = 30.8 bits (68), Expect = 3.9
Identities = 18/69 (26%), Positives = 37/69 (53%), Gaps = 1/69 (1%)
Query: 167 FEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNI 226
F +L +GKG +G V+K + + AIK I ++ A + + +E+ VL+ P +
Sbjct: 36 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEI-EDIQQEITVLSQCDSPYV 94
Query: 227 VGYHTAWIE 235
Y+ ++++
Sbjct: 95 TKYYGSYLK 103
>gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo
sapiens]
Length = 1328
Score = 75.5 bits (184), Expect = 1e-13
Identities = 52/173 (30%), Positives = 84/173 (48%), Gaps = 11/173 (6%)
Query: 417 VATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWT 476
V K +++++GV Y+H +VHRD+K N+ L P +K+ DFG A + W
Sbjct: 1162 VFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLM-PTGIIKLIDFGCA------RRLAWA 1214
Query: 477 NRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF--QPFGTEMER-- 532
NG + S GT + +PE + S Y KSD++S+G + E+ +P M+R
Sbjct: 1215 GLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMA 1274
Query: 533 AEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNS 585
A G G +P A +++ R+ +RPSA+QLL+ + S
Sbjct: 1275 AMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLERS 1327
Score = 39.3 bits (90), Expect = 0.011
Identities = 25/62 (40%), Positives = 32/62 (51%), Gaps = 5/62 (8%)
Query: 172 ILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLR----EVKVLAGLQHPNIV 227
ILGKG YG VY GQ A+K++ + + K K R EV +L L+H NIV
Sbjct: 1066 ILGKGAYGTVYCGLTS-QGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIV 1124
Query: 228 GY 229
Y
Sbjct: 1125 AY 1126
>gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo
sapiens]
Length = 510
Score = 75.5 bits (184), Expect = 1e-13
Identities = 52/173 (30%), Positives = 84/173 (48%), Gaps = 11/173 (6%)
Query: 417 VATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWT 476
V K +++++GV Y+H +VHRD+K N+ L P +K+ DFG A + W
Sbjct: 344 VFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLM-PTGIIKLIDFGCA------RRLAWA 396
Query: 477 NRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF--QPFGTEMER-- 532
NG + S GT + +PE + S Y KSD++S+G + E+ +P M+R
Sbjct: 397 GLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMA 456
Query: 533 AEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNS 585
A G G +P A +++ R+ +RPSA+QLL+ + S
Sbjct: 457 AMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLERS 509
Score = 39.3 bits (90), Expect = 0.011
Identities = 25/62 (40%), Positives = 32/62 (51%), Gaps = 5/62 (8%)
Query: 172 ILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLR----EVKVLAGLQHPNIV 227
ILGKG YG VY GQ A+K++ + + K K R EV +L L+H NIV
Sbjct: 248 ILGKGAYGTVYCGLTS-QGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIV 306
Query: 228 GY 229
Y
Sbjct: 307 AY 308
>gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinase 1
[Homo sapiens]
Length = 671
Score = 74.3 bits (181), Expect = 3e-13
Identities = 64/273 (23%), Positives = 122/273 (44%), Gaps = 12/273 (4%)
Query: 309 NLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEESSEENVNFL 368
N++ +S + + EL G +S Q L + + + + E+ E +
Sbjct: 8 NVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMM 67
Query: 369 GQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVATKIFQELVEG 428
+ ++ ++ + + E + ++E ++G A +V +I E++EG
Sbjct: 68 NRL--RHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEG 125
Query: 429 VFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQK-NTDWTNRNGKRTPTHT 487
+ Y+H G++H+DLKP NI + D +KI D GLA + K N + N + T
Sbjct: 126 MCYLHGKGVIHKDLKPENILVDN-DFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAK 184
Query: 488 SRVGTCLYASPEQLE--GSEYDAKSDMYSLGVVLLELF---QPFGTEMERAEVLTGLRTG 542
GT Y +PE L ++ KSD+YS VVL +F +P+ + +++ +++G
Sbjct: 185 KNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSG 244
Query: 543 QLP--ESLRKRCPVQAKYIQHLT-RRNSSQRPS 572
P + + + CP + + L N RP+
Sbjct: 245 NRPDVDDITEYCPREIISLMKLCWEANPEARPT 277
>gi|148612809 WNK lysine deficient protein kinase 1 [Homo sapiens]
Length = 2382
Score = 73.2 bits (178), Expect = 7e-13
Identities = 54/176 (30%), Positives = 83/176 (47%), Gaps = 21/176 (11%)
Query: 423 QELVEGVFYIHNMG--IVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNG 480
+++++G+ ++H I+HRDLK NIF+ GP VKIGD GLA
Sbjct: 329 RQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL-------------- 374
Query: 481 KRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF---QPFGTEMERAEVLT 537
KR S +GT + +PE E +YD D+Y+ G+ +LE+ P+ A++
Sbjct: 375 KRASFAKSVIGTPEFMAPEMYE-EKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYR 433
Query: 538 GLRTGQLPESLRK-RCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTL 592
+ +G P S K P + I+ R+N +R S LL FQ V + L
Sbjct: 434 RVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEETGVRVEL 489
Score = 37.7 bits (86), Expect = 0.032
Identities = 28/104 (26%), Positives = 54/104 (51%), Gaps = 5/104 (4%)
Query: 130 SAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGRVYKVRNKLD 189
SAKE +++ + I+++ ++ V + + R+L E+ G+G + VYK +
Sbjct: 189 SAKEP-QEERSQQQDDIEELETKAVGM-SNDGRFLKFDIEI---GRGSFKTVYKGLDTET 243
Query: 190 GQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAW 233
A ++ + TK+ + E ++L GLQHPNIV ++ +W
Sbjct: 244 TVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSW 287
>gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Homo
sapiens]
Length = 648
Score = 72.8 bits (177), Expect = 9e-13
Identities = 55/176 (31%), Positives = 86/176 (48%), Gaps = 22/176 (12%)
Query: 421 IFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNG 480
I ++ +G+ Y+H I+HRD+K NIFLH VKIGDFGLA + W+
Sbjct: 448 IARQTAQGMDYLHAKNIIHRDMKSNNIFLH-EGLTVKIGDFGLATV-----KSRWSGSQQ 501
Query: 481 KRTPTHTSRVGTCLYASPEQL---EGSEYDAKSDMYSLGVVLLELFQ---PFGTEMERAE 534
PT G+ L+ +PE + + + + +SD+YS G+VL EL P+ R +
Sbjct: 502 VEQPT-----GSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQ 556
Query: 535 VLTGLRTGQLP---ESLRKRCP-VQAKYIQHLTRRNSSQRPSAIQLLQS-ELFQNS 585
++ + G L K CP + + ++ +RP Q+L S EL Q+S
Sbjct: 557 IIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHS 612
>gi|33188459 B-Raf [Homo sapiens]
Length = 766
Score = 71.6 bits (174), Expect = 2e-12
Identities = 53/169 (31%), Positives = 82/169 (48%), Gaps = 21/169 (12%)
Query: 421 IFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNG 480
I ++ +G+ Y+H I+HRDLK NIFLH D VKIGDFGLA + W+ +
Sbjct: 556 IARQTAQGMDYLHAKSIIHRDLKSNNIFLH-EDLTVKIGDFGLATV-----KSRWSGSH- 608
Query: 481 KRTPTHTSRVGTCLYASPEQL---EGSEYDAKSDMYSLGVVLLELFQ---PFGTEMERAE 534
G+ L+ +PE + + + Y +SD+Y+ G+VL EL P+ R +
Sbjct: 609 ----QFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQ 664
Query: 535 VLTGLRTGQLPESL---RKRCPVQAKYIQ-HLTRRNSSQRPSAIQLLQS 579
++ + G L L R CP K + ++ +RP Q+L S
Sbjct: 665 IIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILAS 713
>gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens]
Length = 1243
Score = 71.2 bits (173), Expect = 3e-12
Identities = 57/204 (27%), Positives = 96/204 (47%), Gaps = 24/204 (11%)
Query: 423 QELVEGVFYIHNM--GIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNG 480
++++ G+ ++H+ I+HRDLK N+F+ GP VKIGD GLA
Sbjct: 282 RQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGSVKIGDLGLATL-------------- 327
Query: 481 KRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF---QPFGTEMERAEVLT 537
KR S +GT + +PE E +YD D+Y+ G+ +LE+ P+ A++
Sbjct: 328 KRASFAKSVIGTPEFMAPEMYE-EKYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYR 386
Query: 538 GLRTGQLPESLRK-RCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKI 596
+ +G+ P S K + P + I+ R + ++R + LL F+ V++ L
Sbjct: 387 KVTSGRKPNSFHKVKIPEVKEIIEGCIRTDKNERFTIQDLLAHAFFREERGVHVELAE-- 444
Query: 597 IEQEKEIAELKKQLNLLSQDKGVR 620
E + E LK L + +G R
Sbjct: 445 -EDDGEKPGLKLWLRMEDARRGGR 467
Score = 34.7 bits (78), Expect = 0.27
Identities = 17/61 (27%), Positives = 33/61 (54%)
Query: 173 LGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTA 232
+G+G + VY+ + A ++ + ++ + EV++L GLQHPNIV ++ +
Sbjct: 180 IGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDS 239
Query: 233 W 233
W
Sbjct: 240 W 240
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 71.2 bits (173), Expect = 3e-12
Identities = 67/245 (27%), Positives = 117/245 (47%), Gaps = 27/245 (11%)
Query: 340 QQLPLRRNSHLEESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNK 399
QQ+ + LEE+ E+ +E + L Q ++ Y + + L LW I+
Sbjct: 47 QQVVAIKIIDLEEAEDEIEDIQQE-ITVLSQCDSSY-VTKYYGSYLKGSKLW--IIMEYL 102
Query: 400 RGREYVDE-SACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKI 458
G +D A P+ +AT + +E+++G+ Y+H+ +HRD+K N+ L VK+
Sbjct: 103 GGGSALDLLRAGPFDEFQIATML-KEILKGLDYLHSEKKIHRDIKAANVLL-SEQGDVKL 160
Query: 459 GDFGLACTDILQKNTDWTNRNGKRTPTHTSR---VGTCLYASPEQLEGSEYDAKSDMYSL 515
DFG+A G+ T T R VGT + +PE ++ S YD+K+D++SL
Sbjct: 161 ADFGVA---------------GQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSL 205
Query: 516 GVVLLELF--QPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSA 573
G+ +EL +P ++M VL + P + ++I ++ S RP+A
Sbjct: 206 GITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTA 265
Query: 574 IQLLQ 578
+LL+
Sbjct: 266 KELLK 270
>gi|50845418 WNK lysine deficient protein kinase 3 isoform 1 [Homo
sapiens]
Length = 1800
Score = 70.5 bits (171), Expect = 4e-12
Identities = 53/176 (30%), Positives = 82/176 (46%), Gaps = 21/176 (11%)
Query: 423 QELVEGVFYIHNMG--IVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNG 480
+++++G+ ++H I+HRDLK NIF+ GP VKIGD GLA
Sbjct: 255 RQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL-------------- 300
Query: 481 KRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF---QPFGTEMERAEVLT 537
RT S +GT + +PE E YD D+Y+ G+ +LE+ P+ A++
Sbjct: 301 MRTSFAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYR 359
Query: 538 GLRTGQLPESLRKRCPVQAK-YIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTL 592
+ +G P S K + K I+ R+N S+R S LL F + + L
Sbjct: 360 KVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVEL 415
Score = 37.7 bits (86), Expect = 0.032
Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 1/88 (1%)
Query: 147 QKIRSREVALEAQTSRYLNEFEELAI-LGKGGYGRVYKVRNKLDGQYYAIKKILIKGATK 205
+K E ++A + F + I LG+G + VYK + A ++ + TK
Sbjct: 126 EKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTK 185
Query: 206 TVCMKVLREVKVLAGLQHPNIVGYHTAW 233
+ E ++L GLQHPNIV ++ +W
Sbjct: 186 AEQQRFKEEAEMLKGLQHPNIVRFYDSW 213
>gi|50845416 WNK lysine deficient protein kinase 3 isoform 2 [Homo
sapiens]
Length = 1743
Score = 70.5 bits (171), Expect = 4e-12
Identities = 53/176 (30%), Positives = 82/176 (46%), Gaps = 21/176 (11%)
Query: 423 QELVEGVFYIHNMG--IVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNG 480
+++++G+ ++H I+HRDLK NIF+ GP VKIGD GLA
Sbjct: 255 RQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL-------------- 300
Query: 481 KRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF---QPFGTEMERAEVLT 537
RT S +GT + +PE E YD D+Y+ G+ +LE+ P+ A++
Sbjct: 301 MRTSFAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYR 359
Query: 538 GLRTGQLPESLRKRCPVQAK-YIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTL 592
+ +G P S K + K I+ R+N S+R S LL F + + L
Sbjct: 360 KVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVEL 415
Score = 37.7 bits (86), Expect = 0.032
Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 1/88 (1%)
Query: 147 QKIRSREVALEAQTSRYLNEFEELAI-LGKGGYGRVYKVRNKLDGQYYAIKKILIKGATK 205
+K E ++A + F + I LG+G + VYK + A ++ + TK
Sbjct: 126 EKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTK 185
Query: 206 TVCMKVLREVKVLAGLQHPNIVGYHTAW 233
+ E ++L GLQHPNIV ++ +W
Sbjct: 186 AEQQRFKEEAEMLKGLQHPNIVRFYDSW 213
>gi|109633028 serine/threonine protein kinase MST4 isoform 2 [Homo
sapiens]
Length = 339
Score = 70.5 bits (171), Expect = 4e-12
Identities = 55/192 (28%), Positives = 95/192 (49%), Gaps = 23/192 (11%)
Query: 393 WIVERNKRGREYVDE-SACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHG 451
WI+ G +D A P+ +AT + +E+++G+ Y+H+ +HRD+K N+ L
Sbjct: 19 WIIMEYLGGGSALDLLRAGPFDEFQIATML-KEILKGLDYLHSEKKIHRDIKAANVLL-S 76
Query: 452 PDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSR---VGTCLYASPEQLEGSEYDA 508
VK+ DFG+A G+ T T R VGT + +PE ++ S YD+
Sbjct: 77 EQGDVKLADFGVA---------------GQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDS 121
Query: 509 KSDMYSLGVVLLELF--QPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRN 566
K+D++SLG+ +EL +P ++M VL + P + ++I ++
Sbjct: 122 KADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKD 181
Query: 567 SSQRPSAIQLLQ 578
S RP+A +LL+
Sbjct: 182 PSFRPTAKELLK 193
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 69.3 bits (168), Expect = 1e-11
Identities = 52/162 (32%), Positives = 81/162 (50%), Gaps = 21/162 (12%)
Query: 416 NVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDW 475
++A K F ++V + Y H + +VHRDLKP N+ VK+ DFG +
Sbjct: 114 DLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSN---------- 163
Query: 476 TNRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKS-DMYSLGVVLLELF--QPFGTEMER 532
+ GK+ T+ G+ Y++PE L G EYDA + D++SLGV+L L QP E
Sbjct: 164 KFQPGKKL---TTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEAND 220
Query: 533 AEVLTGLRTGQ--LPESLRKRCPVQAKYIQHLTRRNSSQRPS 572
+E LT + + +P + K C I + +R+ +R S
Sbjct: 221 SETLTMIMDCKYTVPSHVSKEC---KDLITRMLQRDPKRRAS 259
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 69.3 bits (168), Expect = 1e-11
Identities = 52/162 (32%), Positives = 81/162 (50%), Gaps = 21/162 (12%)
Query: 416 NVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDW 475
++A K F ++V + Y H + +VHRDLKP N+ VK+ DFG +
Sbjct: 114 DLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSN---------- 163
Query: 476 TNRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKS-DMYSLGVVLLELF--QPFGTEMER 532
+ GK+ T+ G+ Y++PE L G EYDA + D++SLGV+L L QP E
Sbjct: 164 KFQPGKKL---TTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEAND 220
Query: 533 AEVLTGLRTGQ--LPESLRKRCPVQAKYIQHLTRRNSSQRPS 572
+E LT + + +P + K C I + +R+ +R S
Sbjct: 221 SETLTMIMDCKYTVPSHVSKEC---KDLITRMLQRDPKRRAS 259
>gi|21359873 polo-like kinase 1 [Homo sapiens]
Length = 603
Score = 68.9 bits (167), Expect = 1e-11
Identities = 59/193 (30%), Positives = 93/193 (48%), Gaps = 29/193 (15%)
Query: 394 IVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPD 453
++E +KR + + A Y+ +++V G Y+H ++HRDLK N+FL+ D
Sbjct: 138 LLELHKRRKALTEPEARYYL---------RQIVLGCQYLHRNRVIHRDLKLGNLFLN-ED 187
Query: 454 QQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMY 513
+VKIGDFGLA +G+R T GT Y +PE L + + D++
Sbjct: 188 LEVKIGDFGLATK---------VEYDGERKKT---LCGTPNYIAPEVLSKKGHSFEVDVW 235
Query: 514 SLGVVLLELF---QPFGTEMERAEVLTGLRTGQLPESLRKRC-PVQAKYIQHLTRRNSSQ 569
S+G ++ L PF T + T LR + S+ K PV A IQ + + + +
Sbjct: 236 SIGCIMYTLLVGKPPFETSCLKE---TYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTA 292
Query: 570 RPSAIQLLQSELF 582
RP+ +LL E F
Sbjct: 293 RPTINELLNDEFF 305
Score = 29.6 bits (65), Expect = 8.8
Identities = 16/62 (25%), Positives = 33/62 (53%), Gaps = 7/62 (11%)
Query: 173 LGKGGYGRVYKVRNKLDGQYYA----IKKILIKGATKTVCMKVLREVKVLAGLQHPNIVG 228
LGKGG+ + +++ + + +A K +L+K + K+ E+ + L H ++VG
Sbjct: 59 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQRE---KMSMEISIHRSLAHQHVVG 115
Query: 229 YH 230
+H
Sbjct: 116 FH 117
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 68.6 bits (166), Expect = 2e-11
Identities = 67/285 (23%), Positives = 125/285 (43%), Gaps = 26/285 (9%)
Query: 350 LEESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESA 409
LEE+ E+ +E + L Q ++ Y + + L LW I+ G +D
Sbjct: 53 LEEAEDEIEDIQQE-ITVLSQCDSPY-ITRYFGSYLKSTKLW--IIMEYLGGGSALDLLK 108
Query: 410 CPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDIL 469
+ I +E+++G+ Y+H+ +HRD+K N+ L VK+ DFG+A
Sbjct: 109 PGPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLL-SEQGDVKLADFGVA----- 162
Query: 470 QKNTDWTNRNGKRTPTHTSR---VGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF--Q 524
G+ T T R VGT + +PE ++ S YD K+D++SLG+ +EL +
Sbjct: 163 ----------GQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGE 212
Query: 525 PFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQN 584
P +++ VL + P + ++++ ++ RP+A +LL+ + F
Sbjct: 213 PPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHK-FIT 271
Query: 585 SGNVNLTLQMKIIEQEKEIAELKKQLNLLSQDKGVRDDGKDGGVG 629
+ ++I++ K S+D + + +DG G
Sbjct: 272 RYTKKTSFLTELIDRYKRWKSEGHGEESSSEDSDIDGEAEDGEQG 316
Score = 31.2 bits (69), Expect = 3.0
Identities = 20/69 (28%), Positives = 36/69 (52%), Gaps = 1/69 (1%)
Query: 167 FEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNI 226
F +L +GKG +G VYK + + AIK I ++ A + + +E+ VL+ P I
Sbjct: 20 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEI-EDIQQEITVLSQCDSPYI 78
Query: 227 VGYHTAWIE 235
Y ++++
Sbjct: 79 TRYFGSYLK 87
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.379
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,328,634
Number of Sequences: 37866
Number of extensions: 1130520
Number of successful extensions: 6241
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 541
Number of HSP's successfully gapped in prelim test: 261
Number of HSP's that attempted gapping in prelim test: 4119
Number of HSP's gapped (non-prelim): 1616
length of query: 629
length of database: 18,247,518
effective HSP length: 108
effective length of query: 521
effective length of database: 14,157,990
effective search space: 7376312790
effective search space used: 7376312790
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.