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Search of human proteins with 194097438
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194097438 protein tyrosine phosphatase, receptor type, N
polypeptide 2 isoform 2 precursor [Homo sapiens]
(998 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194097438 protein tyrosine phosphatase, receptor type, N poly... 1998 0.0
gi|194097440 protein tyrosine phosphatase, receptor type, N poly... 1987 0.0
gi|194097442 protein tyrosine phosphatase, receptor type, N poly... 1917 0.0
gi|4506321 protein tyrosine phosphatase, receptor type, N precur... 690 0.0
gi|194097398 protein tyrosine phosphatase, receptor type, G prec... 189 1e-47
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 188 2e-47
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 187 3e-47
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 187 3e-47
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 187 3e-47
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo... 187 3e-47
gi|208431815 protein tyrosine phosphatase, receptor type, K isof... 186 1e-46
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo... 183 6e-46
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor... 183 6e-46
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo... 183 6e-46
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 182 1e-45
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 182 1e-45
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 182 1e-45
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 182 1e-45
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 182 1e-45
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 182 2e-45
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 182 2e-45
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 181 4e-45
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 181 4e-45
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 180 5e-45
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 180 5e-45
gi|148728162 protein tyrosine phosphatase, receptor type, J isof... 174 3e-43
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p... 174 4e-43
gi|18104993 protein tyrosine phosphatase, non-receptor type 6 is... 170 5e-42
gi|18104989 protein tyrosine phosphatase, non-receptor type 6 is... 170 5e-42
gi|18104991 protein tyrosine phosphatase, non-receptor type 6 is... 170 5e-42
>gi|194097438 protein tyrosine phosphatase, receptor type, N
polypeptide 2 isoform 2 precursor [Homo sapiens]
Length = 998
Score = 1998 bits (5176), Expect = 0.0
Identities = 998/998 (100%), Positives = 998/998 (100%)
Query: 1 MGPPLPLLLLLLLLLPPRVLPAAPSSVPRGRQLPGRLDGVFGRCQKVPAMDFYRYEVSPV 60
MGPPLPLLLLLLLLLPPRVLPAAPSSVPRGRQLPGRLDGVFGRCQKVPAMDFYRYEVSPV
Sbjct: 1 MGPPLPLLLLLLLLLPPRVLPAAPSSVPRGRQLPGRLDGVFGRCQKVPAMDFYRYEVSPV 60
Query: 61 ALQRLRVALQKLSGTGFTWQDDYTQYVMDQELADLPKTYLRRPEASSPARPSKHSVGSER 120
ALQRLRVALQKLSGTGFTWQDDYTQYVMDQELADLPKTYLRRPEASSPARPSKHSVGSER
Sbjct: 61 ALQRLRVALQKLSGTGFTWQDDYTQYVMDQELADLPKTYLRRPEASSPARPSKHSVGSER 120
Query: 121 RYSREGGAALANALRRHLPFLEALSQAPASDVLARTHTAQDRPPAEGDDRFSESILTYVA 180
RYSREGGAALANALRRHLPFLEALSQAPASDVLARTHTAQDRPPAEGDDRFSESILTYVA
Sbjct: 121 RYSREGGAALANALRRHLPFLEALSQAPASDVLARTHTAQDRPPAEGDDRFSESILTYVA 180
Query: 181 HTSALTYPPGSRTQLREDLLPRTLGQLQPDELSPKVDSGVDRHHLMAALSAYAAQRPPAP 240
HTSALTYPPGSRTQLREDLLPRTLGQLQPDELSPKVDSGVDRHHLMAALSAYAAQRPPAP
Sbjct: 181 HTSALTYPPGSRTQLREDLLPRTLGQLQPDELSPKVDSGVDRHHLMAALSAYAAQRPPAP 240
Query: 241 PGEGSLEPQYLLRAPSRMPRPLLAPAAPQKWPSPLGDSEDPSSTGDGARIHTLLKDLQRQ 300
PGEGSLEPQYLLRAPSRMPRPLLAPAAPQKWPSPLGDSEDPSSTGDGARIHTLLKDLQRQ
Sbjct: 241 PGEGSLEPQYLLRAPSRMPRPLLAPAAPQKWPSPLGDSEDPSSTGDGARIHTLLKDLQRQ 300
Query: 301 PAEVRGLSGLELDGMAELMAGLMQGVDHGVARGSPGRAALGESGEQADGPKATLRGDSFP 360
PAEVRGLSGLELDGMAELMAGLMQGVDHGVARGSPGRAALGESGEQADGPKATLRGDSFP
Sbjct: 301 PAEVRGLSGLELDGMAELMAGLMQGVDHGVARGSPGRAALGESGEQADGPKATLRGDSFP 360
Query: 361 DDGVQDDDDRLYQEVHRLSATLGGLLQDHGSRLLPGALPFARPLDMERKKSEHPESSLSS 420
DDGVQDDDDRLYQEVHRLSATLGGLLQDHGSRLLPGALPFARPLDMERKKSEHPESSLSS
Sbjct: 361 DDGVQDDDDRLYQEVHRLSATLGGLLQDHGSRLLPGALPFARPLDMERKKSEHPESSLSS 420
Query: 421 EEETAGVENVKSQTYSKDLLGQQPHSEPGAAAFGELQNQMPGPSKEEQSLPAGAQEALSD 480
EEETAGVENVKSQTYSKDLLGQQPHSEPGAAAFGELQNQMPGPSKEEQSLPAGAQEALSD
Sbjct: 421 EEETAGVENVKSQTYSKDLLGQQPHSEPGAAAFGELQNQMPGPSKEEQSLPAGAQEALSD 480
Query: 481 GLQLEVQPSEEEARGYIVTDRDPLRPEEGRRLVEDVARLLQVPSSAFADVEVLGPAVTFK 540
GLQLEVQPSEEEARGYIVTDRDPLRPEEGRRLVEDVARLLQVPSSAFADVEVLGPAVTFK
Sbjct: 481 GLQLEVQPSEEEARGYIVTDRDPLRPEEGRRLVEDVARLLQVPSSAFADVEVLGPAVTFK 540
Query: 541 VSANVQNVTTEDVEKATVDNKDKLEETSGLKILQTGVGSKSKLKFLPPQAEQEDSTKFIA 600
VSANVQNVTTEDVEKATVDNKDKLEETSGLKILQTGVGSKSKLKFLPPQAEQEDSTKFIA
Sbjct: 541 VSANVQNVTTEDVEKATVDNKDKLEETSGLKILQTGVGSKSKLKFLPPQAEQEDSTKFIA 600
Query: 601 LTLVSLACILGVLLASGLIYCLRHSSQHRLKEKLSGLGGDPGADATAAYQELCRQRMATR 660
LTLVSLACILGVLLASGLIYCLRHSSQHRLKEKLSGLGGDPGADATAAYQELCRQRMATR
Sbjct: 601 LTLVSLACILGVLLASGLIYCLRHSSQHRLKEKLSGLGGDPGADATAAYQELCRQRMATR 660
Query: 661 PPDRPEGPHTSRISSVSSQFSDGPIPSPSARSSASSWSEEPVQSNMDISTGHMILSYMED 720
PPDRPEGPHTSRISSVSSQFSDGPIPSPSARSSASSWSEEPVQSNMDISTGHMILSYMED
Sbjct: 661 PPDRPEGPHTSRISSVSSQFSDGPIPSPSARSSASSWSEEPVQSNMDISTGHMILSYMED 720
Query: 721 HLKNKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSH 780
HLKNKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSH
Sbjct: 721 HLKNKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSH 780
Query: 781 SDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCY 840
SDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCY
Sbjct: 781 SDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCY 840
Query: 841 HYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVP 900
HYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVP
Sbjct: 841 HYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVP 900
Query: 901 SSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAAT 960
SSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAAT
Sbjct: 901 SSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAAT 960
Query: 961 LEHLRDQRPGMVQTKEQFEFALTAVAEEVNAILKALPQ 998
LEHLRDQRPGMVQTKEQFEFALTAVAEEVNAILKALPQ
Sbjct: 961 LEHLRDQRPGMVQTKEQFEFALTAVAEEVNAILKALPQ 998
>gi|194097440 protein tyrosine phosphatase, receptor type, N
polypeptide 2 isoform 1 precursor [Homo sapiens]
Length = 1015
Score = 1987 bits (5148), Expect = 0.0
Identities = 998/1015 (98%), Positives = 998/1015 (98%), Gaps = 17/1015 (1%)
Query: 1 MGPPLPLLLLLLLLLPPRVLPAAPSSVPRGRQLPGRL-----------------DGVFGR 43
MGPPLPLLLLLLLLLPPRVLPAAPSSVPRGRQLPGRL DGVFGR
Sbjct: 1 MGPPLPLLLLLLLLLPPRVLPAAPSSVPRGRQLPGRLGCLLEEGLCGASEACVNDGVFGR 60
Query: 44 CQKVPAMDFYRYEVSPVALQRLRVALQKLSGTGFTWQDDYTQYVMDQELADLPKTYLRRP 103
CQKVPAMDFYRYEVSPVALQRLRVALQKLSGTGFTWQDDYTQYVMDQELADLPKTYLRRP
Sbjct: 61 CQKVPAMDFYRYEVSPVALQRLRVALQKLSGTGFTWQDDYTQYVMDQELADLPKTYLRRP 120
Query: 104 EASSPARPSKHSVGSERRYSREGGAALANALRRHLPFLEALSQAPASDVLARTHTAQDRP 163
EASSPARPSKHSVGSERRYSREGGAALANALRRHLPFLEALSQAPASDVLARTHTAQDRP
Sbjct: 121 EASSPARPSKHSVGSERRYSREGGAALANALRRHLPFLEALSQAPASDVLARTHTAQDRP 180
Query: 164 PAEGDDRFSESILTYVAHTSALTYPPGSRTQLREDLLPRTLGQLQPDELSPKVDSGVDRH 223
PAEGDDRFSESILTYVAHTSALTYPPGSRTQLREDLLPRTLGQLQPDELSPKVDSGVDRH
Sbjct: 181 PAEGDDRFSESILTYVAHTSALTYPPGSRTQLREDLLPRTLGQLQPDELSPKVDSGVDRH 240
Query: 224 HLMAALSAYAAQRPPAPPGEGSLEPQYLLRAPSRMPRPLLAPAAPQKWPSPLGDSEDPSS 283
HLMAALSAYAAQRPPAPPGEGSLEPQYLLRAPSRMPRPLLAPAAPQKWPSPLGDSEDPSS
Sbjct: 241 HLMAALSAYAAQRPPAPPGEGSLEPQYLLRAPSRMPRPLLAPAAPQKWPSPLGDSEDPSS 300
Query: 284 TGDGARIHTLLKDLQRQPAEVRGLSGLELDGMAELMAGLMQGVDHGVARGSPGRAALGES 343
TGDGARIHTLLKDLQRQPAEVRGLSGLELDGMAELMAGLMQGVDHGVARGSPGRAALGES
Sbjct: 301 TGDGARIHTLLKDLQRQPAEVRGLSGLELDGMAELMAGLMQGVDHGVARGSPGRAALGES 360
Query: 344 GEQADGPKATLRGDSFPDDGVQDDDDRLYQEVHRLSATLGGLLQDHGSRLLPGALPFARP 403
GEQADGPKATLRGDSFPDDGVQDDDDRLYQEVHRLSATLGGLLQDHGSRLLPGALPFARP
Sbjct: 361 GEQADGPKATLRGDSFPDDGVQDDDDRLYQEVHRLSATLGGLLQDHGSRLLPGALPFARP 420
Query: 404 LDMERKKSEHPESSLSSEEETAGVENVKSQTYSKDLLGQQPHSEPGAAAFGELQNQMPGP 463
LDMERKKSEHPESSLSSEEETAGVENVKSQTYSKDLLGQQPHSEPGAAAFGELQNQMPGP
Sbjct: 421 LDMERKKSEHPESSLSSEEETAGVENVKSQTYSKDLLGQQPHSEPGAAAFGELQNQMPGP 480
Query: 464 SKEEQSLPAGAQEALSDGLQLEVQPSEEEARGYIVTDRDPLRPEEGRRLVEDVARLLQVP 523
SKEEQSLPAGAQEALSDGLQLEVQPSEEEARGYIVTDRDPLRPEEGRRLVEDVARLLQVP
Sbjct: 481 SKEEQSLPAGAQEALSDGLQLEVQPSEEEARGYIVTDRDPLRPEEGRRLVEDVARLLQVP 540
Query: 524 SSAFADVEVLGPAVTFKVSANVQNVTTEDVEKATVDNKDKLEETSGLKILQTGVGSKSKL 583
SSAFADVEVLGPAVTFKVSANVQNVTTEDVEKATVDNKDKLEETSGLKILQTGVGSKSKL
Sbjct: 541 SSAFADVEVLGPAVTFKVSANVQNVTTEDVEKATVDNKDKLEETSGLKILQTGVGSKSKL 600
Query: 584 KFLPPQAEQEDSTKFIALTLVSLACILGVLLASGLIYCLRHSSQHRLKEKLSGLGGDPGA 643
KFLPPQAEQEDSTKFIALTLVSLACILGVLLASGLIYCLRHSSQHRLKEKLSGLGGDPGA
Sbjct: 601 KFLPPQAEQEDSTKFIALTLVSLACILGVLLASGLIYCLRHSSQHRLKEKLSGLGGDPGA 660
Query: 644 DATAAYQELCRQRMATRPPDRPEGPHTSRISSVSSQFSDGPIPSPSARSSASSWSEEPVQ 703
DATAAYQELCRQRMATRPPDRPEGPHTSRISSVSSQFSDGPIPSPSARSSASSWSEEPVQ
Sbjct: 661 DATAAYQELCRQRMATRPPDRPEGPHTSRISSVSSQFSDGPIPSPSARSSASSWSEEPVQ 720
Query: 704 SNMDISTGHMILSYMEDHLKNKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVL 763
SNMDISTGHMILSYMEDHLKNKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVL
Sbjct: 721 SNMDISTGHMILSYMEDHLKNKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVL 780
Query: 764 TYDHSRVLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCV 823
TYDHSRVLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCV
Sbjct: 781 TYDHSRVLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCV 840
Query: 824 VIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNET 883
VIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNET
Sbjct: 841 VIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNET 900
Query: 884 RTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDM 943
RTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDM
Sbjct: 901 RTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDM 960
Query: 944 VLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAILKALPQ 998
VLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAILKALPQ
Sbjct: 961 VLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAILKALPQ 1015
>gi|194097442 protein tyrosine phosphatase, receptor type, N
polypeptide 2 isoform 3 precursor [Homo sapiens]
Length = 986
Score = 1917 bits (4965), Expect = 0.0
Identities = 969/1015 (95%), Positives = 969/1015 (95%), Gaps = 46/1015 (4%)
Query: 1 MGPPLPLLLLLLLLLPPRVLPAAPSSVPRGRQLPGRL-----------------DGVFGR 43
MGPPLPLLLLLLLLLPPRVLPAAPSSVPRGRQLPGRL DGVFGR
Sbjct: 1 MGPPLPLLLLLLLLLPPRVLPAAPSSVPRGRQLPGRLGCLLEEGLCGASEACVNDGVFGR 60
Query: 44 CQKVPAMDFYRYEVSPVALQRLRVALQKLSGTGFTWQDDYTQYVMDQELADLPKTYLRRP 103
CQKVPAMDFYRYEVSPVALQRLRVALQKLSGTGFTWQDDYTQYVMDQELADLPKTYLRRP
Sbjct: 61 CQKVPAMDFYRYEVSPVALQRLRVALQKLSGTGFTWQDDYTQYVMDQELADLPKTYLRRP 120
Query: 104 EASSPARPSKHSVGSERRYSREGGAALANALRRHLPFLEALSQAPASDVLARTHTAQDRP 163
EASSPARPSKHSVGSERRYSREGGAALANALRRHLPFLEALSQAPASDVLARTHTAQDRP
Sbjct: 121 EASSPARPSKHSVGSERRYSREGGAALANALRRHLPFLEALSQAPASDVLARTHTAQDRP 180
Query: 164 PAEGDDRFSESILTYVAHTSALTYPPGSRTQLREDLLPRTLGQLQPDELSPKVDSGVDRH 223
PAEGDDRFSESILTYVAHTSALTYPPGSRTQLREDLLPRTLGQLQPDELSPKVDSGVDRH
Sbjct: 181 PAEGDDRFSESILTYVAHTSALTYPPGSRTQLREDLLPRTLGQLQPDELSPKVDSGVDRH 240
Query: 224 HLMAALSAYAAQRPPAPPGEGSLEPQYLLRAPSRMPRPLLAPAAPQKWPSPLGDSEDPSS 283
HLMAALSAYAAQRPPAPPGEGSLEPQYLLRAPSRMPRPLLAPAAPQKWPSPLGDSEDPSS
Sbjct: 241 HLMAALSAYAAQRPPAPPGEGSLEPQYLLRAPSRMPRPLLAPAAPQKWPSPLGDSEDPSS 300
Query: 284 TGDGARIHTLLKDLQRQPAEVRGLSGLELDGMAELMAGLMQGVDHGVARGSPGRAALGES 343
TGDGARIHTLLKDLQRQPAEVRGLSGLELDGMAELMAGLMQGVDHGVARGSPGRAALGES
Sbjct: 301 TGDGARIHTLLKDLQRQPAEVRGLSGLELDGMAELMAGLMQGVDHGVARGSPGRAALGES 360
Query: 344 GEQADGPKATLRGDSFPDDGVQDDDDRLYQEVHRLSATLGGLLQDHGSRLLPGALPFARP 403
GEQADGPKATLRGDSFPDDGVQDDDDRLYQEVHRLSATLGGLLQDHGSRLLPGALPFARP
Sbjct: 361 GEQADGPKATLRGDSFPDDGVQDDDDRLYQEVHRLSATLGGLLQDHGSRLLPGALPFARP 420
Query: 404 LDMERKKSEHPESSLSSEEETAGVENVKSQTYSKDLLGQQPHSEPGAAAFGELQNQMPGP 463
LDMERKKSEHPESSLSSEEETAGVENVKSQTYSKDLLGQQPHSEPGAAAFGELQNQMPGP
Sbjct: 421 LDMERKKSEHPESSLSSEEETAGVENVKSQTYSKDLLGQQPHSEPGAAAFGELQNQMPGP 480
Query: 464 SKEEQSLPAGAQEALSDGLQLEVQPSEEEARGYIVTDRDPLRPEEGRRLVEDVARLLQVP 523
SKEEQSLPAGAQEALSDGLQLEVQPSEEEARGYIVTDR
Sbjct: 481 SKEEQSLPAGAQEALSDGLQLEVQPSEEEARGYIVTDR---------------------- 518
Query: 524 SSAFADVEVLGPAVTFKVSANVQNVTTEDVEKATVDNKDKLEETSGLKILQTGVGSKSKL 583
EVLGPAVTFKVSANVQNVTTEDVEKATVDNKDKLEETSGLKILQTGVGSKSKL
Sbjct: 519 -------EVLGPAVTFKVSANVQNVTTEDVEKATVDNKDKLEETSGLKILQTGVGSKSKL 571
Query: 584 KFLPPQAEQEDSTKFIALTLVSLACILGVLLASGLIYCLRHSSQHRLKEKLSGLGGDPGA 643
KFLPPQAEQEDSTKFIALTLVSLACILGVLLASGLIYCLRHSSQHRLKEKLSGLGGDPGA
Sbjct: 572 KFLPPQAEQEDSTKFIALTLVSLACILGVLLASGLIYCLRHSSQHRLKEKLSGLGGDPGA 631
Query: 644 DATAAYQELCRQRMATRPPDRPEGPHTSRISSVSSQFSDGPIPSPSARSSASSWSEEPVQ 703
DATAAYQELCRQRMATRPPDRPEGPHTSRISSVSSQFSDGPIPSPSARSSASSWSEEPVQ
Sbjct: 632 DATAAYQELCRQRMATRPPDRPEGPHTSRISSVSSQFSDGPIPSPSARSSASSWSEEPVQ 691
Query: 704 SNMDISTGHMILSYMEDHLKNKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVL 763
SNMDISTGHMILSYMEDHLKNKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVL
Sbjct: 692 SNMDISTGHMILSYMEDHLKNKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVL 751
Query: 764 TYDHSRVLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCV 823
TYDHSRVLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCV
Sbjct: 752 TYDHSRVLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCV 811
Query: 824 VIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNET 883
VIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNET
Sbjct: 812 VIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNET 871
Query: 884 RTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDM 943
RTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDM
Sbjct: 872 RTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDM 931
Query: 944 VLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAILKALPQ 998
VLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAILKALPQ
Sbjct: 932 VLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAILKALPQ 986
>gi|4506321 protein tyrosine phosphatase, receptor type, N precursor
[Homo sapiens]
Length = 979
Score = 690 bits (1780), Expect = 0.0
Identities = 455/1037 (43%), Positives = 579/1037 (55%), Gaps = 121/1037 (11%)
Query: 8 LLLLLLLLPPRVLPAAPSSVPR-----GRQLPGRL-----DGVFGRCQKVPAMDFYRYEV 57
LLL LLLL R P S+V R+L L DG+FG+CQ +V
Sbjct: 18 LLLCLLLLSSR--PGGCSAVSAHGCLFDRRLCSHLEVCIQDGLFGQCQVGVGQARPLLQV 75
Query: 58 SPVALQRLRVALQKLSGTGFTWQDDYTQYVMDQELADLPKTYLRRPEASSPARPSKHSVG 117
+ LQRL+ L++L G +W DD TQYV+ QE+ +P+ LR PE RP S
Sbjct: 76 TSPVLQRLQGVLRQLMSQGLSWHDDLTQYVISQEMERIPR--LRPPEP----RPRDRSGL 129
Query: 118 SERRYSREGGAALANALRRHLPFLEALSQAPASDVLARTHTAQDRPPAEGDDRFSESILT 177
+ +R G L + P A H P +G S S+
Sbjct: 130 APKRPGPAGELLLQDI--------------PTGSAPAAQHRLPQPPVGKGGAGASSSL-- 173
Query: 178 YVAHTSALTYPPGSRTQLREDLLPRTLGQL----QPDELSPKVDSGVDRHHLMAALSAYA 233
+ L+ +LLP L L QP S + + + +L +
Sbjct: 174 ---------------SPLQAELLPPLLEHLLLPPQPPHPSLSYEPALLQPYLFHQFGSRD 218
Query: 234 AQR-PPAPPGEGSLEPQYLLRAPSRMPRPLLAPAAPQKWPSPLGDSEDPSSTGDGARIHT 292
R PG S+ P AP+ R GD PS
Sbjct: 219 GSRVSEGSPGMVSVGPLPKAEAPALFSRTASKGIFGDHPGHSYGDLPGPS---------- 268
Query: 293 LLKDLQRQPAEVRGLSGLELDGMAELMAGLMQGVDHGVARGSPGRAALGESGEQADGPKA 352
PA++ SGL L EL A V +GS RA G + +G
Sbjct: 269 --------PAQLFQDSGL-LYLAQELPAPSRARVPRLPEQGSSSRAEDSPEGYEKEGLGD 319
Query: 353 TLRGDSFPDDGVQDDDDRLYQEVHRLSATLGG---------------------LLQDHGS 391
RG+ VQ D + RL+A L G LL
Sbjct: 320 --RGEKPASPAVQPD-----AALQRLAAVLAGYGVELRQLTPEQLSTLLTLLQLLPKGAG 372
Query: 392 RLLPGALPFARPLDMERKKSEHPESSLSSEE---ETAGVENVKSQTYSKDLLGQQPH--- 445
R G + + +K E P + E T+ + + + + + Q P
Sbjct: 373 RNPGGVVNVGADI---KKTMEGPVEGRDTAELPARTSPMPGHPTASPTSSEVQQVPSPVS 429
Query: 446 SEPGAAAFGELQNQMPGPSKEEQSLPAGAQEALSDGLQLEVQPSEEEARGYIVTDRDPLR 505
SEP AA + P E+ P G + G Q +P+ EE GYIVTD+ PL
Sbjct: 430 SEPPKAARPPVT-----PVLLEKKSPLGQSQPTVAG-QPSARPAAEEY-GYIVTDQKPLS 482
Query: 506 PEEGRRLVEDVARLLQVPSSAFADVEVLGPAVTFKVSANVQNVTTEDVEKATVDNKDKLE 565
G +L+E +A + + S +F ++ V+GPA+TF++ N QN++ DV + K +LE
Sbjct: 483 LAAGVKLLEILAEHVHMSSGSFINISVVGPALTFRIRHNEQNLSLADVTQQAGLVKSELE 542
Query: 566 ETSGLKILQTGVGSKSKLKFLPPQAEQEDST-KFIALTLVSLACILGVLLASGLIYCLRH 624
+GL+ILQTGVG + + + PQ S + + LTLV+LA + G+L+A + C+R
Sbjct: 543 AQTGLQILQTGVGQREEAAAVLPQTAHSTSPMRSVLLTLVALAGVAGLLVALAVALCVRQ 602
Query: 625 SSQHRLKEKLSGLGGDPG-ADATAAYQELCRQRMATRPP-DRPEGP-HTSRISSVSSQFS 681
++ + KE+L+ LG + D T YQ+LCRQ MAT+ +R EGP SR+SSVSSQFS
Sbjct: 603 HARQQDKERLAALGPEGAHGDTTFEYQDLCRQHMATKSLFNRAEGPPEPSRVSSVSSQFS 662
Query: 682 DGPIPSPSARSSASSWSEEPVQSNMDISTGHMILSYMEDHLKNKNRLEKEWEALCAYQAE 741
D SPS+ SS SW EEP Q+NMDISTGHMIL+YMEDHL+N++RL KEW+ALCAYQAE
Sbjct: 663 DAAQASPSSHSSTPSWCEEPAQANMDISTGHMILAYMEDHLRNRDRLAKEWQALCAYQAE 722
Query: 742 PNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPRNPAYIA 801
PN+ AQ E N+ KNR L YDH+R+ LK E+S S SDYINASPI++HDPR PAYIA
Sbjct: 723 PNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIA 782
Query: 802 TQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSE 861
TQGPL T+ADFWQMVWESGC VIVMLTPL E+GV+QC YWPDEG++LYH+YEVNLVSE
Sbjct: 783 TQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSE 842
Query: 862 HIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRS 921
HIWCEDFLVRSFYLKN+QT ETRT+TQFHFLSW G P+S+R LLDFRRKVNKCYRGRS
Sbjct: 843 HIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRS 902
Query: 922 CPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFA 981
CPIIVHCSDGAGR+GTY+LIDMVLN+MAKG KEIDIAATLEH+RDQRPG+V++K+QFEFA
Sbjct: 903 CPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFA 962
Query: 982 LTAVAEEVNAILKALPQ 998
LTAVAEEVNAILKALPQ
Sbjct: 963 LTAVAEEVNAILKALPQ 979
>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
[Homo sapiens]
Length = 1445
Score = 189 bits (480), Expect = 1e-47
Identities = 173/638 (27%), Positives = 274/638 (42%), Gaps = 71/638 (11%)
Query: 383 GGLLQDHGSRLLPGALPFA--------RPL--DMERKKSEHPESSLSSEEETAGVENVKS 432
GG + S + P LP A RP+ E S P+ S ++ G E +
Sbjct: 523 GGGISSFPSTVWPTRLPTAASASKQAARPVLATTEALASPGPDGDSSPTKDGEGTEEGEK 582
Query: 433 QTYSKDLLGQQPHSEPGAAAFGELQNQMPGPSKEEQS------LPAGAQEALSDGLQLEV 486
S+ G++ H E G + + + EE++ P+ G Q
Sbjct: 583 DEKSESEDGEREHEEDGEKDSEKKEKSGVTHAAEERNQTEPSPTPSSPNRTAEGGHQ--T 640
Query: 487 QPSEEEARGYIVTDRDPLRPEEGRRLVEDVARLLQVPSSAFADVEVLGPAVTFKVSANVQ 546
P E+ + TD+ R + G L D+ QVP P T + A
Sbjct: 641 IPGHEQDHTAVPTDQTGGRRDAGPGLDPDMVTSTQVP-----------PTATEEQYAGSD 689
Query: 547 NVTTEDVEKATVDNKDKLEETSGLKILQTGVGSKSKLKFLPPQAEQEDSTKFIALTLVSL 606
E K + D+ E S + + S + P E I ++ ++
Sbjct: 690 PKRPEMPSKKPMSRGDRFSEDSRFITVNPAEKNTSGMISRPAPGRMEWIIPLIVVSALTF 749
Query: 607 ACILGVLLASGLIYCLRHSSQHRLKEKLSGLGGDPGADATAAYQELCRQRMATRPPDRPE 666
C+ +LL + L+Y +++K K G P +R P
Sbjct: 750 VCL--ILLIAVLVYW---RGCNKIKSK-----GFP-------------RRFREVPSSGER 786
Query: 667 GPHTSRISSVSSQFSDGPIPSPSARSSASSWSEEPVQSNMD-ISTGHMILSYMEDHLKNK 725
G SR ++ F SP + S P+ +M+ I + E + N+
Sbjct: 787 GEKGSRKCFQTAHFYVEDSSSPRVVPNESI-PIIPIPDDMEAIPVKQFVKHIGELYSNNQ 845
Query: 726 NRLEKEWEALCAYQAEPN-SSFVAQREENVPKNRSLAVLTYDHSRVLLKA--ENSHSHSD 782
+ +++E + A+ N ++ + EN KNR + +L YDHSRV L+ HSD
Sbjct: 846 HGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSD 905
Query: 783 YINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHY 842
YINA+ + ++ + AYIATQGPL +T DFW+M+WE +IVM+T L E G R+C Y
Sbjct: 906 YINANYVDGYN-KAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQY 964
Query: 843 WPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNE-----------TRTVTQFHF 891
WP E S Y V L S I + VR F ++N + + R V Q+H+
Sbjct: 965 WPTENSEEYGNIIVTLKSTKIHA-CYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHY 1023
Query: 892 LSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKG 951
W D GVP + +L F R+ + + P++VHCS G GR+GTY++ID +L ++ K
Sbjct: 1024 TQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQI-KD 1082
Query: 952 AKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEV 989
+++ L+H+R QR +VQT+EQ+ F A+ E +
Sbjct: 1083 KSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI 1120
Score = 106 bits (264), Expect = 1e-22
Identities = 81/271 (29%), Positives = 128/271 (47%), Gaps = 10/271 (3%)
Query: 725 KNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYI 784
K RLEK+++ + A+ F AQ+E N KNR+ +V+ + +RV L +DYI
Sbjct: 1147 KTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYI 1206
Query: 785 NASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWP 844
NAS IM + R+ +I TQ PLP T DFW+M+W+ +IVML P ++ + YWP
Sbjct: 1207 NASYIMGY-YRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVML-PDNQSLAEDEFVYWP 1264
Query: 845 D-EGSNLYHIYEVNLVSEHIWC----EDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGV 899
E S + V L+S+ C E ++ F L+ Q + V F W +
Sbjct: 1265 SREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDA 1324
Query: 900 PSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAA 959
P S S + + + R P IVH GA +G + L++ + +D+
Sbjct: 1325 PIS--STFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCAL-TTLSQQLENENAVDVFQ 1381
Query: 960 TLEHLRDQRPGMVQTKEQFEFALTAVAEEVN 990
+ + RPG+ EQ++F A+ V+
Sbjct: 1382 VAKMINLMRPGVFTDIEQYQFIYKAMLSLVS 1412
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 188 bits (477), Expect = 2e-47
Identities = 122/340 (35%), Positives = 174/340 (51%), Gaps = 16/340 (4%)
Query: 653 CRQRMATRPPDRPEGPHTSRISSVSSQFSDGPIPSPSARSSASSWSEEPVQSNMDISTGH 712
C A P P+ P R ++ Q D + SP + E + S+ I
Sbjct: 1323 CLLNNADLAPHHPKDPVEMR--RINFQTPDSGLRSPLREPG---FHFESMLSHPPIPIAD 1377
Query: 713 MILSYMEDHLKNKNRLEKEWEALCAYQAEPNSSFVAQR---EENVPKNRSLAVLTYDHSR 769
M + +L +E+E++ +P F + E N PKNR V+ YDHSR
Sbjct: 1378 MAEHTERLKANDSLKLSQEYESI-----DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSR 1432
Query: 770 VLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLT 829
V+L+ SDYINA+ + + +N AYIATQGPLP T DFW+MVWE IVM+T
Sbjct: 1433 VILQPIEGIMGSDYINANYVDGYRCQN-AYIATQGPLPETFGDFWRMVWEQRSATIVMMT 1491
Query: 830 PLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQF 889
L E +C YWP+ G+ Y +V L+ + I F VR+F L ++E R V QF
Sbjct: 1492 RLEEKSRIKCDQYWPNRGTETYGFIQVTLL-DTIELATFCVRTFSLHKNGSSEKREVRQF 1550
Query: 890 HFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMA 949
F +W D GVP L F R+V C + PI+VHCS G GR+G +++ID +L ++
Sbjct: 1551 QFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERI- 1609
Query: 950 KGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEV 989
K K +D+ + +R QR MVQT++Q+ F A+ E V
Sbjct: 1610 KPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1649
Score = 179 bits (455), Expect = 9e-45
Identities = 99/262 (37%), Positives = 153/262 (58%), Gaps = 5/262 (1%)
Query: 728 LEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINAS 787
+E E++ L +A + A N KNR + ++ Y+ +RV L+ SDYINAS
Sbjct: 1680 MELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINAS 1739
Query: 788 PIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEG 847
+D + AYIATQGPL T DFW+M+WE+ ++VMLT L E G +C+ YWP E
Sbjct: 1740 -FIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAER 1798
Query: 848 SNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLL 907
S Y + V+ ++E+ +++R F + + + ++RTV QF F W ++GVP S +
Sbjct: 1799 SARYQYFVVDPMAEYN-MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFI 1857
Query: 908 DFRRKVNKCYR--GRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLR 965
DF +V+K G+ PI VHCS G GR+G ++ + +VL +M + +DI T++ LR
Sbjct: 1858 DFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM-RYEGVVDIFQTVKMLR 1916
Query: 966 DQRPGMVQTKEQFEFALTAVAE 987
QRP MVQT+++++F A E
Sbjct: 1917 TQRPAMVQTEDEYQFCYQAALE 1938
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 187 bits (476), Expect = 3e-47
Identities = 108/266 (40%), Positives = 152/266 (57%), Gaps = 11/266 (4%)
Query: 727 RLEKEWEALCAYQAEPNSSFVAQR---EENVPKNRSLAVLTYDHSRVLLKAENSHSHSDY 783
+L +E+E++ +P F + E N PKNR V+ YDHSRV+L+ SDY
Sbjct: 949 KLSQEYESI-----DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDY 1003
Query: 784 INASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYW 843
INA+ + + +N AYIATQGPLP T DFW+MVWE IVM+T L E +C YW
Sbjct: 1004 INANYVDGYRCQN-AYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYW 1062
Query: 844 PDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSS 903
P+ G+ Y +V L+ + I F VR+F L ++E R V QF F +W D GVP
Sbjct: 1063 PNRGTETYGFIQVTLL-DTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYP 1121
Query: 904 RSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEH 963
L F R+V C + PI+VHCS G GR+G +++ID +L ++ K K +D+ +
Sbjct: 1122 TPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERI-KPEKTVDVYGHVTL 1180
Query: 964 LRDQRPGMVQTKEQFEFALTAVAEEV 989
+R QR MVQT++Q+ F A+ E V
Sbjct: 1181 MRSQRNYMVQTEDQYSFIHEALLEAV 1206
Score = 179 bits (455), Expect = 9e-45
Identities = 99/262 (37%), Positives = 153/262 (58%), Gaps = 5/262 (1%)
Query: 728 LEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINAS 787
+E E++ L +A + A N KNR + ++ Y+ +RV L+ SDYINAS
Sbjct: 1237 MELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINAS 1296
Query: 788 PIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEG 847
+D + AYIATQGPL T DFW+M+WE+ ++VMLT L E G +C+ YWP E
Sbjct: 1297 -FIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAER 1355
Query: 848 SNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLL 907
S Y + V+ ++E+ +++R F + + + ++RTV QF F W ++GVP S +
Sbjct: 1356 SARYQYFVVDPMAEYN-MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFI 1414
Query: 908 DFRRKVNKCYR--GRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLR 965
DF +V+K G+ PI VHCS G GR+G ++ + +VL +M + +DI T++ LR
Sbjct: 1415 DFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM-RYEGVVDIFQTVKMLR 1473
Query: 966 DQRPGMVQTKEQFEFALTAVAE 987
QRP MVQT+++++F A E
Sbjct: 1474 TQRPAMVQTEDEYQFCYQAALE 1495
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 187 bits (476), Expect = 3e-47
Identities = 108/266 (40%), Positives = 152/266 (57%), Gaps = 11/266 (4%)
Query: 727 RLEKEWEALCAYQAEPNSSFVAQR---EENVPKNRSLAVLTYDHSRVLLKAENSHSHSDY 783
+L +E+E++ +P F + E N PKNR V+ YDHSRV+L+ SDY
Sbjct: 1354 KLSQEYESI-----DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDY 1408
Query: 784 INASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYW 843
INA+ + + +N AYIATQGPLP T DFW+MVWE IVM+T L E +C YW
Sbjct: 1409 INANYVDGYRCQN-AYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYW 1467
Query: 844 PDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSS 903
P+ G+ Y +V L+ + I F VR+F L ++E R V QF F +W D GVP
Sbjct: 1468 PNRGTETYGFIQVTLL-DTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYP 1526
Query: 904 RSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEH 963
L F R+V C + PI+VHCS G GR+G +++ID +L ++ K K +D+ +
Sbjct: 1527 TPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERI-KPEKTVDVYGHVTL 1585
Query: 964 LRDQRPGMVQTKEQFEFALTAVAEEV 989
+R QR MVQT++Q+ F A+ E V
Sbjct: 1586 MRSQRNYMVQTEDQYSFIHEALLEAV 1611
Score = 179 bits (455), Expect = 9e-45
Identities = 99/262 (37%), Positives = 153/262 (58%), Gaps = 5/262 (1%)
Query: 728 LEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINAS 787
+E E++ L +A + A N KNR + ++ Y+ +RV L+ SDYINAS
Sbjct: 1642 MELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINAS 1701
Query: 788 PIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEG 847
+D + AYIATQGPL T DFW+M+WE+ ++VMLT L E G +C+ YWP E
Sbjct: 1702 -FIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAER 1760
Query: 848 SNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLL 907
S Y + V+ ++E+ +++R F + + + ++RTV QF F W ++GVP S +
Sbjct: 1761 SARYQYFVVDPMAEYN-MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFI 1819
Query: 908 DFRRKVNKCYR--GRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLR 965
DF +V+K G+ PI VHCS G GR+G ++ + +VL +M + +DI T++ LR
Sbjct: 1820 DFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM-RYEGVVDIFQTVKMLR 1878
Query: 966 DQRPGMVQTKEQFEFALTAVAE 987
QRP MVQT+++++F A E
Sbjct: 1879 TQRPAMVQTEDEYQFCYQAALE 1900
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 187 bits (476), Expect = 3e-47
Identities = 108/266 (40%), Positives = 152/266 (57%), Gaps = 11/266 (4%)
Query: 727 RLEKEWEALCAYQAEPNSSFVAQR---EENVPKNRSLAVLTYDHSRVLLKAENSHSHSDY 783
+L +E+E++ +P F + E N PKNR V+ YDHSRV+L+ SDY
Sbjct: 945 KLSQEYESI-----DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDY 999
Query: 784 INASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYW 843
INA+ + + +N AYIATQGPLP T DFW+MVWE IVM+T L E +C YW
Sbjct: 1000 INANYVDGYRCQN-AYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYW 1058
Query: 844 PDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSS 903
P+ G+ Y +V L+ + I F VR+F L ++E R V QF F +W D GVP
Sbjct: 1059 PNRGTETYGFIQVTLL-DTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYP 1117
Query: 904 RSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEH 963
L F R+V C + PI+VHCS G GR+G +++ID +L ++ K K +D+ +
Sbjct: 1118 TPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERI-KPEKTVDVYGHVTL 1176
Query: 964 LRDQRPGMVQTKEQFEFALTAVAEEV 989
+R QR MVQT++Q+ F A+ E V
Sbjct: 1177 MRSQRNYMVQTEDQYSFIHEALLEAV 1202
Score = 179 bits (455), Expect = 9e-45
Identities = 99/262 (37%), Positives = 153/262 (58%), Gaps = 5/262 (1%)
Query: 728 LEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINAS 787
+E E++ L +A + A N KNR + ++ Y+ +RV L+ SDYINAS
Sbjct: 1233 MELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINAS 1292
Query: 788 PIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEG 847
+D + AYIATQGPL T DFW+M+WE+ ++VMLT L E G +C+ YWP E
Sbjct: 1293 -FIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAER 1351
Query: 848 SNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLL 907
S Y + V+ ++E+ +++R F + + + ++RTV QF F W ++GVP S +
Sbjct: 1352 SARYQYFVVDPMAEYN-MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFI 1410
Query: 908 DFRRKVNKCYR--GRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLR 965
DF +V+K G+ PI VHCS G GR+G ++ + +VL +M + +DI T++ LR
Sbjct: 1411 DFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM-RYEGVVDIFQTVKMLR 1469
Query: 966 DQRPGMVQTKEQFEFALTAVAE 987
QRP MVQT+++++F A E
Sbjct: 1470 TQRPAMVQTEDEYQFCYQAALE 1491
>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
[Homo sapiens]
Length = 1440
Score = 187 bits (476), Expect = 3e-47
Identities = 109/259 (42%), Positives = 158/259 (61%), Gaps = 6/259 (2%)
Query: 729 EKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASP 788
++E+E+ ++ + S VA++++N KNR ++ YDHSRV+L+ SDYINA+
Sbjct: 889 KEEYESF--FEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANY 946
Query: 789 IMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGS 848
I D R YIATQGP+ TV DFW+M+W+ IVM+T L E G +CY YWPD+ +
Sbjct: 947 I-DGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDD-T 1004
Query: 849 NLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLD 908
+Y ++V V E ++VR+F L+ NE R V QFHF W D GVP + LL
Sbjct: 1005 EVYGDFKVTCVEMEPLAE-YVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLS 1063
Query: 909 FRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQR 968
F R+V + PI+VHCS GAGR+G Y++ID++L+ MA+ +DI ++ LR +R
Sbjct: 1064 FIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLD-MAEREGVVDIYNCVKALRSRR 1122
Query: 969 PGMVQTKEQFEFALTAVAE 987
MVQT+EQ+ F A+ E
Sbjct: 1123 INMVQTEEQYIFIHDAILE 1141
Score = 124 bits (310), Expect = 6e-28
Identities = 97/279 (34%), Positives = 141/279 (50%), Gaps = 20/279 (7%)
Query: 720 DHLKNKNRLEKEWEALCAY----QAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAE 775
D N + L+ E++ L + QAE S +A N KNR + +L D L
Sbjct: 1166 DSQTNSSHLKDEFQTLNSVTPRLQAEDCS--IACLPRNHDKNRFMDMLPPDRCLPFLITI 1223
Query: 776 NSHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENG 835
+ S S+YINA+ +MD + A+I TQ PLP TV DFW++V++ GC IVML + +
Sbjct: 1224 DGES-SNYINAA-LMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLS- 1280
Query: 836 VRQCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNET--RTVTQFHFLS 893
+ C YWP+EG Y +V +S + C D + R F + NL + V QF +L
Sbjct: 1281 -QGCPQYWPEEGMLRYGPIQVECMSCSMDC-DVINRIFRICNLTRPQEGYLMVQQFQYLG 1338
Query: 894 WYD-RGVPSSSRSLLDFRRKVNK----CYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKM 948
W R VP S RS L +V K C G I+HC +G GRSG + I +V+ +M
Sbjct: 1339 WASHREVPGSKRSFLKLILQVEKWQEECEEGEG-RTIIHCLNGGGRSGMFCAIGIVV-EM 1396
Query: 949 AKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAE 987
K +D+ ++ LR+ +P MV+ EQ+ F E
Sbjct: 1397 VKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALE 1435
>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
[Homo sapiens]
Length = 1446
Score = 186 bits (471), Expect = 1e-46
Identities = 109/264 (41%), Positives = 158/264 (59%), Gaps = 10/264 (3%)
Query: 729 EKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASP 788
++E+E+ ++ + S VA++++N KNR ++ YDHSRV+L+ SDYINA+
Sbjct: 889 KEEYESF--FEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANY 946
Query: 789 I-----MDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYW 843
I D R YIATQGP+ TV DFW+M+W+ IVM+T L E G +CY YW
Sbjct: 947 IDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYW 1006
Query: 844 PDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSS 903
PD+ + +Y ++V V E ++VR+F L+ NE R V QFHF W D GVP +
Sbjct: 1007 PDD-TEVYGDFKVTCVEMEPLAE-YVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHA 1064
Query: 904 RSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEH 963
LL F R+V + PI+VHCS GAGR+G Y++ID++L+ MA+ +DI ++
Sbjct: 1065 TGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLD-MAEREGVVDIYNCVKA 1123
Query: 964 LRDQRPGMVQTKEQFEFALTAVAE 987
LR +R MVQT+EQ+ F A+ E
Sbjct: 1124 LRSRRINMVQTEEQYIFIHDAILE 1147
Score = 124 bits (310), Expect = 6e-28
Identities = 97/279 (34%), Positives = 141/279 (50%), Gaps = 20/279 (7%)
Query: 720 DHLKNKNRLEKEWEALCAY----QAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAE 775
D N + L+ E++ L + QAE S +A N KNR + +L D L
Sbjct: 1172 DSQTNSSHLKDEFQTLNSVTPRLQAEDCS--IACLPRNHDKNRFMDMLPPDRCLPFLITI 1229
Query: 776 NSHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENG 835
+ S S+YINA+ +MD + A+I TQ PLP TV DFW++V++ GC IVML + +
Sbjct: 1230 DGES-SNYINAA-LMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLS- 1286
Query: 836 VRQCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNET--RTVTQFHFLS 893
+ C YWP+EG Y +V +S + C D + R F + NL + V QF +L
Sbjct: 1287 -QGCPQYWPEEGMLRYGPIQVECMSCSMDC-DVINRIFRICNLTRPQEGYLMVQQFQYLG 1344
Query: 894 WYD-RGVPSSSRSLLDFRRKVNK----CYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKM 948
W R VP S RS L +V K C G I+HC +G GRSG + I +V+ +M
Sbjct: 1345 WASHREVPGSKRSFLKLILQVEKWQEECEEGEG-RTIIHCLNGGGRSGMFCAIGIVV-EM 1402
Query: 949 AKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAE 987
K +D+ ++ LR+ +P MV+ EQ+ F E
Sbjct: 1403 VKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALE 1441
>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform
2 precursor [Homo sapiens]
Length = 793
Score = 183 bits (465), Expect = 6e-46
Identities = 100/269 (37%), Positives = 153/269 (56%), Gaps = 4/269 (1%)
Query: 724 NKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDY 783
+ N LE+E++ L + + + + N+ KNR L ++ Y+ +RV++ + ++DY
Sbjct: 520 SNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDY 579
Query: 784 INASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYW 843
+NAS +D + +YIA+QGPL T+ DFW+M+WE IVMLT L E G +C YW
Sbjct: 580 VNAS-FIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYW 638
Query: 844 PDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSS 903
P +G Y V L E CE + VR + N + N++R + QFHF W + G+PS
Sbjct: 639 PSDGLVSYGDITVELKKEE-ECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDG 697
Query: 904 RSLLDFRRKVNK-CYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLE 962
+ ++ V K + + PI VHCS GAGR+GT+ + VL ++ K +D+ T++
Sbjct: 698 KGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERV-KAEGILDVFQTVK 756
Query: 963 HLRDQRPGMVQTKEQFEFALTAVAEEVNA 991
LR QRP MVQT EQ+EF V E ++A
Sbjct: 757 SLRLQRPHMVQTLEQYEFCYKVVQEYIDA 785
Score = 172 bits (437), Expect = 1e-42
Identities = 110/273 (40%), Positives = 152/273 (55%), Gaps = 13/273 (4%)
Query: 722 LKNKNRL-EKEWEAL--CAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSH 778
+ + N+L +E+ AL C QA + A +EEN KNR + +L YDHSRV L
Sbjct: 225 MADDNKLFREEFNALPACPIQATCEA---ASKEENKEKNRYVNILPYDHSRVHLTPVEGV 281
Query: 779 SHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQ 838
SDYINAS I + +N +IA QGP TV DFW+M+WE IVM+T L E +
Sbjct: 282 PDSDYINASFINGYQEKNK-FIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECK 340
Query: 839 CYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNL--QTNET--RTVTQFHFLSW 894
C YWPD+G Y V+ V + D+ VR F ++ + TN R +TQFHF SW
Sbjct: 341 CAQYWPDQGCWTYGNIRVS-VEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSW 399
Query: 895 YDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKE 954
D GVP + +L F +KV C + I+VHCS G GR+GT+V+ID +L+ M ++
Sbjct: 400 PDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLD-MMHTERK 458
Query: 955 IDIAATLEHLRDQRPGMVQTKEQFEFALTAVAE 987
+D+ + +R QR MVQT Q+ F A+ E
Sbjct: 459 VDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE 491
>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
precursor [Homo sapiens]
Length = 802
Score = 183 bits (465), Expect = 6e-46
Identities = 100/269 (37%), Positives = 153/269 (56%), Gaps = 4/269 (1%)
Query: 724 NKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDY 783
+ N LE+E++ L + + + + N+ KNR L ++ Y+ +RV++ + ++DY
Sbjct: 529 SNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDY 588
Query: 784 INASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYW 843
+NAS +D + +YIA+QGPL T+ DFW+M+WE IVMLT L E G +C YW
Sbjct: 589 VNAS-FIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYW 647
Query: 844 PDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSS 903
P +G Y V L E CE + VR + N + N++R + QFHF W + G+PS
Sbjct: 648 PSDGLVSYGDITVELKKEE-ECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDG 706
Query: 904 RSLLDFRRKVNK-CYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLE 962
+ ++ V K + + PI VHCS GAGR+GT+ + VL ++ K +D+ T++
Sbjct: 707 KGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERV-KAEGILDVFQTVK 765
Query: 963 HLRDQRPGMVQTKEQFEFALTAVAEEVNA 991
LR QRP MVQT EQ+EF V E ++A
Sbjct: 766 SLRLQRPHMVQTLEQYEFCYKVVQEYIDA 794
Score = 172 bits (437), Expect = 1e-42
Identities = 110/273 (40%), Positives = 152/273 (55%), Gaps = 13/273 (4%)
Query: 722 LKNKNRL-EKEWEAL--CAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSH 778
+ + N+L +E+ AL C QA + A +EEN KNR + +L YDHSRV L
Sbjct: 234 MADDNKLFREEFNALPACPIQATCEA---ASKEENKEKNRYVNILPYDHSRVHLTPVEGV 290
Query: 779 SHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQ 838
SDYINAS I + +N +IA QGP TV DFW+M+WE IVM+T L E +
Sbjct: 291 PDSDYINASFINGYQEKNK-FIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECK 349
Query: 839 CYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNL--QTNET--RTVTQFHFLSW 894
C YWPD+G Y V+ V + D+ VR F ++ + TN R +TQFHF SW
Sbjct: 350 CAQYWPDQGCWTYGNIRVS-VEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSW 408
Query: 895 YDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKE 954
D GVP + +L F +KV C + I+VHCS G GR+GT+V+ID +L+ M ++
Sbjct: 409 PDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLD-MMHTERK 467
Query: 955 IDIAATLEHLRDQRPGMVQTKEQFEFALTAVAE 987
+D+ + +R QR MVQT Q+ F A+ E
Sbjct: 468 VDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE 500
>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform
2 precursor [Homo sapiens]
Length = 793
Score = 183 bits (465), Expect = 6e-46
Identities = 100/269 (37%), Positives = 153/269 (56%), Gaps = 4/269 (1%)
Query: 724 NKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDY 783
+ N LE+E++ L + + + + N+ KNR L ++ Y+ +RV++ + ++DY
Sbjct: 520 SNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDY 579
Query: 784 INASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYW 843
+NAS +D + +YIA+QGPL T+ DFW+M+WE IVMLT L E G +C YW
Sbjct: 580 VNAS-FIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYW 638
Query: 844 PDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSS 903
P +G Y V L E CE + VR + N + N++R + QFHF W + G+PS
Sbjct: 639 PSDGLVSYGDITVELKKEE-ECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDG 697
Query: 904 RSLLDFRRKVNK-CYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLE 962
+ ++ V K + + PI VHCS GAGR+GT+ + VL ++ K +D+ T++
Sbjct: 698 KGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERV-KAEGILDVFQTVK 756
Query: 963 HLRDQRPGMVQTKEQFEFALTAVAEEVNA 991
LR QRP MVQT EQ+EF V E ++A
Sbjct: 757 SLRLQRPHMVQTLEQYEFCYKVVQEYIDA 785
Score = 172 bits (437), Expect = 1e-42
Identities = 110/273 (40%), Positives = 152/273 (55%), Gaps = 13/273 (4%)
Query: 722 LKNKNRL-EKEWEAL--CAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSH 778
+ + N+L +E+ AL C QA + A +EEN KNR + +L YDHSRV L
Sbjct: 225 MADDNKLFREEFNALPACPIQATCEA---ASKEENKEKNRYVNILPYDHSRVHLTPVEGV 281
Query: 779 SHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQ 838
SDYINAS I + +N +IA QGP TV DFW+M+WE IVM+T L E +
Sbjct: 282 PDSDYINASFINGYQEKNK-FIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECK 340
Query: 839 CYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNL--QTNET--RTVTQFHFLSW 894
C YWPD+G Y V+ V + D+ VR F ++ + TN R +TQFHF SW
Sbjct: 341 CAQYWPDQGCWTYGNIRVS-VEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSW 399
Query: 895 YDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKE 954
D GVP + +L F +KV C + I+VHCS G GR+GT+V+ID +L+ M ++
Sbjct: 400 PDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLD-MMHTERK 458
Query: 955 IDIAATLEHLRDQRPGMVQTKEQFEFALTAVAE 987
+D+ + +R QR MVQT Q+ F A+ E
Sbjct: 459 VDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE 491
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 182 bits (463), Expect = 1e-45
Identities = 101/267 (37%), Positives = 156/267 (58%), Gaps = 5/267 (1%)
Query: 723 KNKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSD 782
+N +E E++ L + +A + A N KNR + ++ Y+ +RV L+ SD
Sbjct: 1229 ENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSD 1288
Query: 783 YINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHY 842
YINAS +D + AYIATQGPL T DFW+M+WE ++VMLT L E G +C+ Y
Sbjct: 1289 YINAS-FIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQY 1347
Query: 843 WPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSS 902
WP E S Y + V+ ++E+ +++R F + + + ++RTV QF F W ++GVP S
Sbjct: 1348 WPAERSARYQYFVVDPMAEYN-MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKS 1406
Query: 903 SRSLLDFRRKVNKCYR--GRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAAT 960
+DF +V+K G+ PI VHCS G GR+G ++ + +VL +M + +DI T
Sbjct: 1407 GEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM-RYEGVVDIFQT 1465
Query: 961 LEHLRDQRPGMVQTKEQFEFALTAVAE 987
++ LR QRP MVQT++Q++F+ A E
Sbjct: 1466 VKMLRTQRPAMVQTEDQYQFSYRAALE 1492
Score = 182 bits (462), Expect = 1e-45
Identities = 120/343 (34%), Positives = 178/343 (51%), Gaps = 34/343 (9%)
Query: 662 PDRPEGPHTSRISSVSSQFSDGPIPSPSARSSASSWSEEPVQ-SNMDISTGHMI------ 714
PDR SR SS+ P+ + S +PV+ ++ T M
Sbjct: 880 PDRKRAESDSRKSSI-----------PNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIP 928
Query: 715 LSYMEDHLK----NKN-RLEKEWEALCAYQAEPNSSFVAQR---EENVPKNRSLAVLTYD 766
+ + DH++ N N + +E+E++ +P F + E N PKNR V+ YD
Sbjct: 929 ILELADHIERLKANDNLKFSQEYESI-----DPGQQFTWEHSNLEVNKPKNRYANVIAYD 983
Query: 767 HSRVLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIV 826
HSRVLL A SDY+NA+ I + +N AYIATQG LP T DFW+M+WE +V
Sbjct: 984 HSRVLLSAIEGIPGSDYVNANYIDGYRKQN-AYIATQGSLPETFGDFWRMIWEQRSATVV 1042
Query: 827 MLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTV 886
M+T L E +C YWP G+ + + +V L+ + + + VR+F L ++E R V
Sbjct: 1043 MMTKLEERSRVKCDQYWPSRGTETHGLVQVTLL-DTVELATYCVRTFALYKNGSSEKREV 1101
Query: 887 TQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLN 946
QF F +W D GVP L F R+V C + P++VHCS G GR+G +++ID +L
Sbjct: 1102 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1161
Query: 947 KMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEV 989
++ K K +DI + +R QR MVQT++Q+ F A+ E V
Sbjct: 1162 RI-KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1203
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 182 bits (463), Expect = 1e-45
Identities = 101/267 (37%), Positives = 156/267 (58%), Gaps = 5/267 (1%)
Query: 723 KNKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSD 782
+N +E E++ L + +A + A N KNR + ++ Y+ +RV L+ SD
Sbjct: 1639 ENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSD 1698
Query: 783 YINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHY 842
YINAS +D + AYIATQGPL T DFW+M+WE ++VMLT L E G +C+ Y
Sbjct: 1699 YINAS-FIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQY 1757
Query: 843 WPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSS 902
WP E S Y + V+ ++E+ +++R F + + + ++RTV QF F W ++GVP S
Sbjct: 1758 WPAERSARYQYFVVDPMAEYN-MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKS 1816
Query: 903 SRSLLDFRRKVNKCYR--GRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAAT 960
+DF +V+K G+ PI VHCS G GR+G ++ + +VL +M + +DI T
Sbjct: 1817 GEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM-RYEGVVDIFQT 1875
Query: 961 LEHLRDQRPGMVQTKEQFEFALTAVAE 987
++ LR QRP MVQT++Q++F+ A E
Sbjct: 1876 VKMLRTQRPAMVQTEDQYQFSYRAALE 1902
Score = 181 bits (458), Expect = 4e-45
Identities = 107/280 (38%), Positives = 157/280 (56%), Gaps = 16/280 (5%)
Query: 718 MEDHLK----NKN-RLEKEWEALCAYQAEPNSSFVAQR---EENVPKNRSLAVLTYDHSR 769
+ DH++ N N + +E+E++ +P F + E N PKNR V+ YDHSR
Sbjct: 1342 LADHIERLKANDNLKFSQEYESI-----DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSR 1396
Query: 770 VLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLT 829
VLL A SDY+NA+ I + +N AYIATQG LP T DFW+M+WE +VM+T
Sbjct: 1397 VLLSAIEGIPGSDYVNANYIDGYRKQN-AYIATQGSLPETFGDFWRMIWEQRSATVVMMT 1455
Query: 830 PLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQF 889
L E +C YWP G+ + + +V L+ + + + VR+F L ++E R V QF
Sbjct: 1456 KLEERSRVKCDQYWPSRGTETHGLVQVTLL-DTVELATYCVRTFALYKNGSSEKREVRQF 1514
Query: 890 HFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMA 949
F +W D GVP L F R+V C + P++VHCS G GR+G +++ID +L ++
Sbjct: 1515 QFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI- 1573
Query: 950 KGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEV 989
K K +DI + +R QR MVQT++Q+ F A+ E V
Sbjct: 1574 KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1613
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 182 bits (463), Expect = 1e-45
Identities = 101/267 (37%), Positives = 156/267 (58%), Gaps = 5/267 (1%)
Query: 723 KNKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSD 782
+N +E E++ L + +A + A N KNR + ++ Y+ +RV L+ SD
Sbjct: 1626 ENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSD 1685
Query: 783 YINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHY 842
YINAS +D + AYIATQGPL T DFW+M+WE ++VMLT L E G +C+ Y
Sbjct: 1686 YINAS-FIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQY 1744
Query: 843 WPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSS 902
WP E S Y + V+ ++E+ +++R F + + + ++RTV QF F W ++GVP S
Sbjct: 1745 WPAERSARYQYFVVDPMAEYN-MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKS 1803
Query: 903 SRSLLDFRRKVNKCYR--GRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAAT 960
+DF +V+K G+ PI VHCS G GR+G ++ + +VL +M + +DI T
Sbjct: 1804 GEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM-RYEGVVDIFQT 1862
Query: 961 LEHLRDQRPGMVQTKEQFEFALTAVAE 987
++ LR QRP MVQT++Q++F+ A E
Sbjct: 1863 VKMLRTQRPAMVQTEDQYQFSYRAALE 1889
Score = 181 bits (458), Expect = 4e-45
Identities = 107/280 (38%), Positives = 157/280 (56%), Gaps = 16/280 (5%)
Query: 718 MEDHLK----NKN-RLEKEWEALCAYQAEPNSSFVAQR---EENVPKNRSLAVLTYDHSR 769
+ DH++ N N + +E+E++ +P F + E N PKNR V+ YDHSR
Sbjct: 1329 LADHIERLKANDNLKFSQEYESI-----DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSR 1383
Query: 770 VLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLT 829
VLL A SDY+NA+ I + +N AYIATQG LP T DFW+M+WE +VM+T
Sbjct: 1384 VLLSAIEGIPGSDYVNANYIDGYRKQN-AYIATQGSLPETFGDFWRMIWEQRSATVVMMT 1442
Query: 830 PLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQF 889
L E +C YWP G+ + + +V L+ + + + VR+F L ++E R V QF
Sbjct: 1443 KLEERSRVKCDQYWPSRGTETHGLVQVTLL-DTVELATYCVRTFALYKNGSSEKREVRQF 1501
Query: 890 HFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMA 949
F +W D GVP L F R+V C + P++VHCS G GR+G +++ID +L ++
Sbjct: 1502 QFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI- 1560
Query: 950 KGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEV 989
K K +DI + +R QR MVQT++Q+ F A+ E V
Sbjct: 1561 KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1600
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 182 bits (463), Expect = 1e-45
Identities = 101/267 (37%), Positives = 156/267 (58%), Gaps = 5/267 (1%)
Query: 723 KNKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSD 782
+N +E E++ L + +A + A N KNR + ++ Y+ +RV L+ SD
Sbjct: 1630 ENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSD 1689
Query: 783 YINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHY 842
YINAS +D + AYIATQGPL T DFW+M+WE ++VMLT L E G +C+ Y
Sbjct: 1690 YINAS-FIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQY 1748
Query: 843 WPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSS 902
WP E S Y + V+ ++E+ +++R F + + + ++RTV QF F W ++GVP S
Sbjct: 1749 WPAERSARYQYFVVDPMAEYN-MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKS 1807
Query: 903 SRSLLDFRRKVNKCYR--GRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAAT 960
+DF +V+K G+ PI VHCS G GR+G ++ + +VL +M + +DI T
Sbjct: 1808 GEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM-RYEGVVDIFQT 1866
Query: 961 LEHLRDQRPGMVQTKEQFEFALTAVAE 987
++ LR QRP MVQT++Q++F+ A E
Sbjct: 1867 VKMLRTQRPAMVQTEDQYQFSYRAALE 1893
Score = 181 bits (458), Expect = 4e-45
Identities = 107/280 (38%), Positives = 157/280 (56%), Gaps = 16/280 (5%)
Query: 718 MEDHLK----NKN-RLEKEWEALCAYQAEPNSSFVAQR---EENVPKNRSLAVLTYDHSR 769
+ DH++ N N + +E+E++ +P F + E N PKNR V+ YDHSR
Sbjct: 1333 LADHIERLKANDNLKFSQEYESI-----DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSR 1387
Query: 770 VLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLT 829
VLL A SDY+NA+ I + +N AYIATQG LP T DFW+M+WE +VM+T
Sbjct: 1388 VLLSAIEGIPGSDYVNANYIDGYRKQN-AYIATQGSLPETFGDFWRMIWEQRSATVVMMT 1446
Query: 830 PLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQF 889
L E +C YWP G+ + + +V L+ + + + VR+F L ++E R V QF
Sbjct: 1447 KLEERSRVKCDQYWPSRGTETHGLVQVTLL-DTVELATYCVRTFALYKNGSSEKREVRQF 1505
Query: 890 HFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMA 949
F +W D GVP L F R+V C + P++VHCS G GR+G +++ID +L ++
Sbjct: 1506 QFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI- 1564
Query: 950 KGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEV 989
K K +DI + +R QR MVQT++Q+ F A+ E V
Sbjct: 1565 KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1604
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 182 bits (463), Expect = 1e-45
Identities = 101/267 (37%), Positives = 156/267 (58%), Gaps = 5/267 (1%)
Query: 723 KNKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSD 782
+N +E E++ L + +A + A N KNR + ++ Y+ +RV L+ SD
Sbjct: 1228 ENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSD 1287
Query: 783 YINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHY 842
YINAS +D + AYIATQGPL T DFW+M+WE ++VMLT L E G +C+ Y
Sbjct: 1288 YINAS-FIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQY 1346
Query: 843 WPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSS 902
WP E S Y + V+ ++E+ +++R F + + + ++RTV QF F W ++GVP S
Sbjct: 1347 WPAERSARYQYFVVDPMAEYN-MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKS 1405
Query: 903 SRSLLDFRRKVNKCYR--GRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAAT 960
+DF +V+K G+ PI VHCS G GR+G ++ + +VL +M + +DI T
Sbjct: 1406 GEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM-RYEGVVDIFQT 1464
Query: 961 LEHLRDQRPGMVQTKEQFEFALTAVAE 987
++ LR QRP MVQT++Q++F+ A E
Sbjct: 1465 VKMLRTQRPAMVQTEDQYQFSYRAALE 1491
Score = 181 bits (458), Expect = 4e-45
Identities = 107/280 (38%), Positives = 157/280 (56%), Gaps = 16/280 (5%)
Query: 718 MEDHLK----NKN-RLEKEWEALCAYQAEPNSSFVAQR---EENVPKNRSLAVLTYDHSR 769
+ DH++ N N + +E+E++ +P F + E N PKNR V+ YDHSR
Sbjct: 931 LADHIERLKANDNLKFSQEYESI-----DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSR 985
Query: 770 VLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLT 829
VLL A SDY+NA+ I + +N AYIATQG LP T DFW+M+WE +VM+T
Sbjct: 986 VLLSAIEGIPGSDYVNANYIDGYRKQN-AYIATQGSLPETFGDFWRMIWEQRSATVVMMT 1044
Query: 830 PLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQF 889
L E +C YWP G+ + + +V L+ + + + VR+F L ++E R V QF
Sbjct: 1045 KLEERSRVKCDQYWPSRGTETHGLVQVTLL-DTVELATYCVRTFALYKNGSSEKREVRQF 1103
Query: 890 HFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMA 949
F +W D GVP L F R+V C + P++VHCS G GR+G +++ID +L ++
Sbjct: 1104 QFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI- 1162
Query: 950 KGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEV 989
K K +DI + +R QR MVQT++Q+ F A+ E V
Sbjct: 1163 KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1202
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 182 bits (461), Expect = 2e-45
Identities = 103/264 (39%), Positives = 153/264 (57%), Gaps = 11/264 (4%)
Query: 727 RLEKEWEALCAYQAEPNSSFVAQR---EENVPKNRSLAVLTYDHSRVLLKAENSHSHSDY 783
+ +E+E++ +P F + E N PKNR V+ YDHSRV+L + + SDY
Sbjct: 1351 KFSQEYESI-----DPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDY 1405
Query: 784 INASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYW 843
INA+ I + +N AYIATQGPLP T+ DFW+MVWE +VM+T L E +C YW
Sbjct: 1406 INANYIDGYRKQN-AYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYW 1464
Query: 844 PDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSS 903
P G+ + +V L+ + + + VR+F L ++E R + QF F++W D GVP
Sbjct: 1465 PARGTETCGLIQVTLL-DTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYP 1523
Query: 904 RSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEH 963
+L F R+V C + P++VHCS G GR+G +++ID +L +M K K +DI +
Sbjct: 1524 TPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERM-KHEKTVDIYGHVTC 1582
Query: 964 LRDQRPGMVQTKEQFEFALTAVAE 987
+R QR MVQT++Q+ F A+ E
Sbjct: 1583 MRSQRNYMVQTEDQYVFIHEALLE 1606
Score = 175 bits (443), Expect = 2e-43
Identities = 96/262 (36%), Positives = 152/262 (58%), Gaps = 5/262 (1%)
Query: 728 LEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINAS 787
+E E++ L + +A + A N KNR + ++ Y+ +RV L+ SDYINAS
Sbjct: 1639 MELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINAS 1698
Query: 788 PIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEG 847
+D + AYIATQGPL + DFW+M+WE +IVMLT L E G +C+ YWP E
Sbjct: 1699 -FLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAER 1757
Query: 848 SNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLL 907
S Y + V+ ++E+ +++R F + + + ++RT+ QF F W ++GVP + +
Sbjct: 1758 SARYQYFVVDPMAEYN-MPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFI 1816
Query: 908 DFRRKVNKCYR--GRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLR 965
DF +V+K G+ PI VHCS G GR+G ++ + +VL +M + +D+ T++ LR
Sbjct: 1817 DFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERM-RYEGVVDMFQTVKTLR 1875
Query: 966 DQRPGMVQTKEQFEFALTAVAE 987
QRP MVQT++Q++ A E
Sbjct: 1876 TQRPAMVQTEDQYQLCYRAALE 1897
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 182 bits (461), Expect = 2e-45
Identities = 103/264 (39%), Positives = 153/264 (57%), Gaps = 11/264 (4%)
Query: 727 RLEKEWEALCAYQAEPNSSFVAQR---EENVPKNRSLAVLTYDHSRVLLKAENSHSHSDY 783
+ +E+E++ +P F + E N PKNR V+ YDHSRV+L + + SDY
Sbjct: 1342 KFSQEYESI-----DPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDY 1396
Query: 784 INASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYW 843
INA+ I + +N AYIATQGPLP T+ DFW+MVWE +VM+T L E +C YW
Sbjct: 1397 INANYIDGYRKQN-AYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYW 1455
Query: 844 PDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSS 903
P G+ + +V L+ + + + VR+F L ++E R + QF F++W D GVP
Sbjct: 1456 PARGTETCGLIQVTLL-DTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYP 1514
Query: 904 RSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEH 963
+L F R+V C + P++VHCS G GR+G +++ID +L +M K K +DI +
Sbjct: 1515 TPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERM-KHEKTVDIYGHVTC 1573
Query: 964 LRDQRPGMVQTKEQFEFALTAVAE 987
+R QR MVQT++Q+ F A+ E
Sbjct: 1574 MRSQRNYMVQTEDQYVFIHEALLE 1597
Score = 175 bits (443), Expect = 2e-43
Identities = 96/262 (36%), Positives = 152/262 (58%), Gaps = 5/262 (1%)
Query: 728 LEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINAS 787
+E E++ L + +A + A N KNR + ++ Y+ +RV L+ SDYINAS
Sbjct: 1630 MELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINAS 1689
Query: 788 PIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEG 847
+D + AYIATQGPL + DFW+M+WE +IVMLT L E G +C+ YWP E
Sbjct: 1690 -FLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAER 1748
Query: 848 SNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLL 907
S Y + V+ ++E+ +++R F + + + ++RT+ QF F W ++GVP + +
Sbjct: 1749 SARYQYFVVDPMAEYN-MPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFI 1807
Query: 908 DFRRKVNKCYR--GRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLR 965
DF +V+K G+ PI VHCS G GR+G ++ + +VL +M + +D+ T++ LR
Sbjct: 1808 DFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERM-RYEGVVDMFQTVKTLR 1866
Query: 966 DQRPGMVQTKEQFEFALTAVAE 987
QRP MVQT++Q++ A E
Sbjct: 1867 TQRPAMVQTEDQYQLCYRAALE 1888
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 181 bits (458), Expect = 4e-45
Identities = 102/259 (39%), Positives = 155/259 (59%), Gaps = 6/259 (2%)
Query: 729 EKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASP 788
++E+E+ Q+ P S A+++EN KNR ++ YDHSRV L+ ++SDYIN +
Sbjct: 901 KEEYESFFEGQSAPWDS--AKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNY 958
Query: 789 IMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGS 848
I D R YIATQGP+ T+ DFW+MVW I+M+T L E G +C YWPD+ +
Sbjct: 959 I-DGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-T 1016
Query: 849 NLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLD 908
+Y +V L+ + E +++R+F ++ +E R + QFHF W D GVP + LL
Sbjct: 1017 EIYKDIKVTLIETELLAE-YVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLG 1075
Query: 909 FRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQR 968
F R+V + P++VHCS GAGR+G +++ID++L+ MA+ +DI + LR +R
Sbjct: 1076 FVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLD-MAEREGVVDIYNCVRELRSRR 1134
Query: 969 PGMVQTKEQFEFALTAVAE 987
MVQT+EQ+ F A+ E
Sbjct: 1135 VNMVQTEEQYVFIHDAILE 1153
Score = 125 bits (315), Expect = 2e-28
Identities = 86/251 (34%), Positives = 130/251 (51%), Gaps = 12/251 (4%)
Query: 747 VAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGPL 806
+A N KNR + +L D L + S S+YINA+ +MD + A+I TQ PL
Sbjct: 1207 IALLPRNHEKNRCMDILPPDRCLPFLITIDGES-SNYINAA-LMDSYKQPSAFIVTQHPL 1264
Query: 807 PATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCE 866
P TV DFW++V + C +VML + + + C YWP+ G + + +V VS + E
Sbjct: 1265 PNTVKDFWRLVLDYHCTSVVMLNDV--DPAQLCPQYWPENGVHRHGPIQVEFVSADLE-E 1321
Query: 867 DFLVRSFYLKNLQTNET--RTVTQFHFLSW-YDRGVPSSSRSLLDFRRKVNKC---YRGR 920
D + R F + N + R V QF FL W R P S RS L R+V+K Y G
Sbjct: 1322 DIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGG 1381
Query: 921 SCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEF 980
+VHC +G GRSGT+ I +V +M + + +D+ ++ LR+ +P MV +Q++F
Sbjct: 1382 EGRTVVHCLNGGGRSGTFCAISIVC-EMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKF 1440
Query: 981 ALTAVAEEVNA 991
E +N+
Sbjct: 1441 CYEVALEYLNS 1451
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 181 bits (458), Expect = 4e-45
Identities = 102/259 (39%), Positives = 155/259 (59%), Gaps = 6/259 (2%)
Query: 729 EKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASP 788
++E+E+ Q+ P S A+++EN KNR ++ YDHSRV L+ ++SDYIN +
Sbjct: 914 KEEYESFFEGQSAPWDS--AKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNY 971
Query: 789 IMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGS 848
I D R YIATQGP+ T+ DFW+MVW I+M+T L E G +C YWPD+ +
Sbjct: 972 I-DGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-T 1029
Query: 849 NLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLD 908
+Y +V L+ + E +++R+F ++ +E R + QFHF W D GVP + LL
Sbjct: 1030 EIYKDIKVTLIETELLAE-YVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLG 1088
Query: 909 FRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQR 968
F R+V + P++VHCS GAGR+G +++ID++L+ MA+ +DI + LR +R
Sbjct: 1089 FVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLD-MAEREGVVDIYNCVRELRSRR 1147
Query: 969 PGMVQTKEQFEFALTAVAE 987
MVQT+EQ+ F A+ E
Sbjct: 1148 VNMVQTEEQYVFIHDAILE 1166
Score = 125 bits (315), Expect = 2e-28
Identities = 86/251 (34%), Positives = 130/251 (51%), Gaps = 12/251 (4%)
Query: 747 VAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGPL 806
+A N KNR + +L D L + S S+YINA+ +MD + A+I TQ PL
Sbjct: 1220 IALLPRNHEKNRCMDILPPDRCLPFLITIDGES-SNYINAA-LMDSYKQPSAFIVTQHPL 1277
Query: 807 PATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCE 866
P TV DFW++V + C +VML + + + C YWP+ G + + +V VS + E
Sbjct: 1278 PNTVKDFWRLVLDYHCTSVVMLNDV--DPAQLCPQYWPENGVHRHGPIQVEFVSADLE-E 1334
Query: 867 DFLVRSFYLKNLQTNET--RTVTQFHFLSW-YDRGVPSSSRSLLDFRRKVNKC---YRGR 920
D + R F + N + R V QF FL W R P S RS L R+V+K Y G
Sbjct: 1335 DIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGG 1394
Query: 921 SCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEF 980
+VHC +G GRSGT+ I +V +M + + +D+ ++ LR+ +P MV +Q++F
Sbjct: 1395 EGRTVVHCLNGGGRSGTFCAISIVC-EMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKF 1453
Query: 981 ALTAVAEEVNA 991
E +N+
Sbjct: 1454 CYEVALEYLNS 1464
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 180 bits (457), Expect = 5e-45
Identities = 107/260 (41%), Positives = 155/260 (59%), Gaps = 8/260 (3%)
Query: 729 EKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASP 788
++E+EAL + + S A+ +EN KNR +++YDHSRV L + HSDYINA+
Sbjct: 890 KEEYEALP--EGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANY 947
Query: 789 IMD-HDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEG 847
I H PR+ YIATQGP+ TV DFW+M+W+ IVM+T L E G +C YWPD+
Sbjct: 948 IDGYHRPRH--YIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDD- 1004
Query: 848 SNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLL 907
+ +Y +V L+ E +++R+F ++ +E R + FHF SW D GVP + LL
Sbjct: 1005 TEVYGDIKVTLIETEPLAE-YVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLL 1063
Query: 908 DFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQ 967
F R+V + PI+VHCS GAGR+G ++ ID +L+ MA+ +DI + LR Q
Sbjct: 1064 GFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLD-MAENEGVVDIFNCVRELRAQ 1122
Query: 968 RPGMVQTKEQFEFALTAVAE 987
R +VQT+EQ+ F A+ E
Sbjct: 1123 RVNLVQTEEQYVFVHDAILE 1142
Score = 130 bits (327), Expect = 6e-30
Identities = 92/280 (32%), Positives = 144/280 (51%), Gaps = 14/280 (5%)
Query: 720 DHLKNKNRLEKEWEAL--CAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENS 777
D N ++++ E++ L + P + N KNRS+ VL D L + +
Sbjct: 1167 DPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG 1226
Query: 778 HSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVR 837
S S+YINA+ +MD + A++ TQ PLP TVADFW++V++ C +VML + + +
Sbjct: 1227 ES-SNYINAA-LMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM--DTAQ 1282
Query: 838 QCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNET--RTVTQFHFLSW- 894
C YWP++ S Y +V VS I ED + R F + N+ + R V ++ W
Sbjct: 1283 FCMQYWPEKTSGCYGPIQVEFVSADI-DEDIIHRIFRICNMARPQDGYRIVQHLQYIGWP 1341
Query: 895 YDRGVPSSSRSLLDFRRKVNKC---YRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKG 951
R P S RSLL R++ K Y GR +VHC +G GRSGT+ I V +M +
Sbjct: 1342 AYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVC-EMIQQ 1400
Query: 952 AKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNA 991
ID+ ++ LR+ + MV+T EQ++F E +++
Sbjct: 1401 QNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS 1440
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 180 bits (457), Expect = 5e-45
Identities = 107/260 (41%), Positives = 155/260 (59%), Gaps = 8/260 (3%)
Query: 729 EKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASP 788
++E+EAL + + S A+ +EN KNR +++YDHSRV L + HSDYINA+
Sbjct: 909 KEEYEALP--EGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANY 966
Query: 789 IMD-HDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEG 847
I H PR+ YIATQGP+ TV DFW+M+W+ IVM+T L E G +C YWPD+
Sbjct: 967 IDGYHRPRH--YIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDD- 1023
Query: 848 SNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLL 907
+ +Y +V L+ E +++R+F ++ +E R + FHF SW D GVP + LL
Sbjct: 1024 TEVYGDIKVTLIETEPLAE-YVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLL 1082
Query: 908 DFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQ 967
F R+V + PI+VHCS GAGR+G ++ ID +L+ MA+ +DI + LR Q
Sbjct: 1083 GFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLD-MAENEGVVDIFNCVRELRAQ 1141
Query: 968 RPGMVQTKEQFEFALTAVAE 987
R +VQT+EQ+ F A+ E
Sbjct: 1142 RVNLVQTEEQYVFVHDAILE 1161
Score = 130 bits (327), Expect = 6e-30
Identities = 92/280 (32%), Positives = 144/280 (51%), Gaps = 14/280 (5%)
Query: 720 DHLKNKNRLEKEWEAL--CAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENS 777
D N ++++ E++ L + P + N KNRS+ VL D L + +
Sbjct: 1186 DPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG 1245
Query: 778 HSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVR 837
S S+YINA+ +MD + A++ TQ PLP TVADFW++V++ C +VML + + +
Sbjct: 1246 ES-SNYINAA-LMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM--DTAQ 1301
Query: 838 QCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNET--RTVTQFHFLSW- 894
C YWP++ S Y +V VS I ED + R F + N+ + R V ++ W
Sbjct: 1302 FCMQYWPEKTSGCYGPIQVEFVSADI-DEDIIHRIFRICNMARPQDGYRIVQHLQYIGWP 1360
Query: 895 YDRGVPSSSRSLLDFRRKVNKC---YRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKG 951
R P S RSLL R++ K Y GR +VHC +G GRSGT+ I V +M +
Sbjct: 1361 AYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVC-EMIQQ 1419
Query: 952 AKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNA 991
ID+ ++ LR+ + MV+T EQ++F E +++
Sbjct: 1420 QNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS 1459
>gi|148728162 protein tyrosine phosphatase, receptor type, J isoform 1
precursor [Homo sapiens]
Length = 1337
Score = 174 bits (442), Expect = 3e-43
Identities = 99/248 (39%), Positives = 145/248 (58%), Gaps = 6/248 (2%)
Query: 746 FVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGP 805
+ A+ EN KNR VL YD SRV L + +HS DYINA+ + + + +IATQGP
Sbjct: 1058 YAAELAENRGKNRYNNVLPYDISRVKLSVQ-THSTDDYINANYMPGYHSKKD-FIATQGP 1115
Query: 806 LPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWC 865
LP T+ DFW+MVWE I+MLT E G +C YWP + + Y V + SE I
Sbjct: 1116 LPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSE-IVL 1174
Query: 866 EDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGR--SCP 923
++ +R F +KN+QT+E+ + QFHF SW D GVP ++ L++FR V + P
Sbjct: 1175 PEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESP 1234
Query: 924 IIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALT 983
I+VHCS G GR+GT++ ID ++ ++ + +D+ + LR RP MVQT++Q+ F
Sbjct: 1235 ILVHCSAGVGRTGTFIAIDRLIYQI-ENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQ 1293
Query: 984 AVAEEVNA 991
V + V +
Sbjct: 1294 CVLDIVRS 1301
>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
precursor [Homo sapiens]
Length = 2315
Score = 174 bits (441), Expect = 4e-43
Identities = 105/278 (37%), Positives = 153/278 (55%), Gaps = 21/278 (7%)
Query: 730 KEWEALCAYQAEPNSSFV--------AQREENVPKNRSLAVLTYDHSRVLLK--AENSHS 779
+E+E L + E S V + +N KNR + ++ YDHSRV L AE
Sbjct: 1719 EEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGK 1778
Query: 780 HSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQC 839
+DYINA+ + ++ R AYIA QGPL +T DFW+M+WE VIVM+T L E G R+C
Sbjct: 1779 LTDYINANYVDGYN-RPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKC 1837
Query: 840 YHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNE--------TRTVTQFHF 891
YWP +GS Y + V S + + VR+F L+N + + R VTQ+H+
Sbjct: 1838 DQYWPADGSEEYGNFLVTQKSVQVLAY-YTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHY 1896
Query: 892 LSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKG 951
W D GVP S +L F RK R P++VHCS G GR+GTY+++D +L ++ +
Sbjct: 1897 TQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQI-QH 1955
Query: 952 AKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEV 989
++I L+H+R QR +VQT+EQ+ F + E +
Sbjct: 1956 EGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI 1993
Score = 102 bits (253), Expect = 2e-21
Identities = 70/271 (25%), Positives = 132/271 (48%), Gaps = 11/271 (4%)
Query: 725 KNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYI 784
K +LEK+++ L + + A ++ N KNR+ +++ + SRV + + + +DYI
Sbjct: 2020 KTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEG-TDYI 2078
Query: 785 NASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWP 844
NAS IM + N +I TQ PL T+ DFW+M+W+ ++VM+ P +N + YWP
Sbjct: 2079 NASYIMGYYQSNE-FIITQHPLLHTIKDFWRMIWDHNAQLVVMI-PDGQNMAEDEFVYWP 2136
Query: 845 DEGSNL-YHIYEVNLVSEHIWC----EDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGV 899
++ + ++V L++E C E +++ F L+ Q + V F W +
Sbjct: 2137 NKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDS 2196
Query: 900 PSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAA 959
P S + + + R P+IVH G +GT+ + +++++ K +D+
Sbjct: 2197 PIS--KTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEK-ENSVDVYQ 2253
Query: 960 TLEHLRDQRPGMVQTKEQFEFALTAVAEEVN 990
+ + RPG+ EQ++F + V+
Sbjct: 2254 VAKMINLMRPGVFADIEQYQFLYKVILSLVS 2284
>gi|18104993 protein tyrosine phosphatase, non-receptor type 6
isoform 3 [Homo sapiens]
Length = 624
Score = 170 bits (431), Expect = 5e-42
Identities = 106/259 (40%), Positives = 146/259 (56%), Gaps = 12/259 (4%)
Query: 749 QREENVPKNRSLAVLTYDHSRVLLKAENSH-SHSDYINASPIMDH----DPRNPAYIATQ 803
QR EN KNR +L +DHSRV+L+ +S+ SDYINA+ I + D YIA+Q
Sbjct: 266 QRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQ 325
Query: 804 GPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEG-SNLYHIYEVNLVSEH 862
G L ATV DFWQM W+ VIVM T E G +C YWP+ G Y Y V EH
Sbjct: 326 GCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEH 385
Query: 863 IWCEDFLVRSFYLKNLQTNE-TRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRG-- 919
E + +R+ + L + R + + +LSW D GVPS +L F ++N+
Sbjct: 386 DTTE-YKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLP 444
Query: 920 RSCPIIVHCSDGAGRSGTYVLIDMVL-NKMAKGAK-EIDIAATLEHLRDQRPGMVQTKEQ 977
+ PIIVHCS G GR+GT ++IDM++ N KG +IDI T++ +R QR GMVQT+ Q
Sbjct: 445 HAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQ 504
Query: 978 FEFALTAVAEEVNAILKAL 996
++F A+A+ + K L
Sbjct: 505 YKFIYVAIAQFIETTKKKL 523
>gi|18104989 protein tyrosine phosphatase, non-receptor type 6
isoform 1 [Homo sapiens]
Length = 595
Score = 170 bits (431), Expect = 5e-42
Identities = 106/259 (40%), Positives = 146/259 (56%), Gaps = 12/259 (4%)
Query: 749 QREENVPKNRSLAVLTYDHSRVLLKAENSH-SHSDYINASPIMDH----DPRNPAYIATQ 803
QR EN KNR +L +DHSRV+L+ +S+ SDYINA+ I + D YIA+Q
Sbjct: 266 QRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQ 325
Query: 804 GPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEG-SNLYHIYEVNLVSEH 862
G L ATV DFWQM W+ VIVM T E G +C YWP+ G Y Y V EH
Sbjct: 326 GCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEH 385
Query: 863 IWCEDFLVRSFYLKNLQTNE-TRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRG-- 919
E + +R+ + L + R + + +LSW D GVPS +L F ++N+
Sbjct: 386 DTTE-YKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLP 444
Query: 920 RSCPIIVHCSDGAGRSGTYVLIDMVL-NKMAKGAK-EIDIAATLEHLRDQRPGMVQTKEQ 977
+ PIIVHCS G GR+GT ++IDM++ N KG +IDI T++ +R QR GMVQT+ Q
Sbjct: 445 HAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQ 504
Query: 978 FEFALTAVAEEVNAILKAL 996
++F A+A+ + K L
Sbjct: 505 YKFIYVAIAQFIETTKKKL 523
>gi|18104991 protein tyrosine phosphatase, non-receptor type 6
isoform 2 [Homo sapiens]
Length = 597
Score = 170 bits (431), Expect = 5e-42
Identities = 106/259 (40%), Positives = 146/259 (56%), Gaps = 12/259 (4%)
Query: 749 QREENVPKNRSLAVLTYDHSRVLLKAENSH-SHSDYINASPIMDH----DPRNPAYIATQ 803
QR EN KNR +L +DHSRV+L+ +S+ SDYINA+ I + D YIA+Q
Sbjct: 268 QRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQ 327
Query: 804 GPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEG-SNLYHIYEVNLVSEH 862
G L ATV DFWQM W+ VIVM T E G +C YWP+ G Y Y V EH
Sbjct: 328 GCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEH 387
Query: 863 IWCEDFLVRSFYLKNLQTNE-TRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRG-- 919
E + +R+ + L + R + + +LSW D GVPS +L F ++N+
Sbjct: 388 DTTE-YKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLP 446
Query: 920 RSCPIIVHCSDGAGRSGTYVLIDMVL-NKMAKGAK-EIDIAATLEHLRDQRPGMVQTKEQ 977
+ PIIVHCS G GR+GT ++IDM++ N KG +IDI T++ +R QR GMVQT+ Q
Sbjct: 447 HAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQ 506
Query: 978 FEFALTAVAEEVNAILKAL 996
++F A+A+ + K L
Sbjct: 507 YKFIYVAIAQFIETTKKKL 525
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,615,043
Number of Sequences: 37866
Number of extensions: 2300002
Number of successful extensions: 8529
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 103
Number of HSP's successfully gapped in prelim test: 128
Number of HSP's that attempted gapping in prelim test: 7789
Number of HSP's gapped (non-prelim): 466
length of query: 998
length of database: 18,247,518
effective HSP length: 112
effective length of query: 886
effective length of database: 14,006,526
effective search space: 12409782036
effective search space used: 12409782036
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.