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Search of human proteins with 194097330
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194097330 hexokinase 3 [Homo sapiens]
(923 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194097330 hexokinase 3 [Homo sapiens] 1817 0.0
gi|15553127 hexokinase 2 [Homo sapiens] 1013 0.0
gi|156151420 hexokinase domain containing 1 [Homo sapiens] 950 0.0
gi|188497754 hexokinase 1 isoform HKI [Homo sapiens] 945 0.0
gi|188497750 hexokinase 1 isoform HKI-td [Homo sapiens] 945 0.0
gi|15991829 hexokinase 1 isoform HKI-ta/tb [Homo sapiens] 944 0.0
gi|15991831 hexokinase 1 isoform HKI-ta/tb [Homo sapiens] 944 0.0
gi|15991827 hexokinase 1 isoform HKI-R [Homo sapiens] 944 0.0
gi|4503951 glucokinase isoform 1 [Homo sapiens] 475 e-134
gi|15967159 glucokinase isoform 2 [Homo sapiens] 474 e-133
gi|15967161 glucokinase isoform 3 [Homo sapiens] 473 e-133
gi|41872631 fatty acid synthase [Homo sapiens] 34 0.55
gi|187607437 hypothetical protein LOC27013 [Homo sapiens] 33 0.94
gi|73747879 rabconnectin-3 beta isoform 2 [Homo sapiens] 33 1.6
gi|73747877 rabconnectin-3 beta isoform 1 [Homo sapiens] 33 1.6
gi|50428935 BPY2 interacting protein 1 [Homo sapiens] 32 3.6
gi|155030185 hypothetical protein LOC55726 [Homo sapiens] 31 4.6
gi|193788651 leucine rich repeat containing 69 [Homo sapiens] 30 7.9
>gi|194097330 hexokinase 3 [Homo sapiens]
Length = 923
Score = 1817 bits (4706), Expect = 0.0
Identities = 923/923 (100%), Positives = 923/923 (100%)
Query: 1 MDSIGSSGLRQGEETLSCSEEGLPGPSDSSELVQECLQQFKVTRAQLQQIQASLLGSMEQ 60
MDSIGSSGLRQGEETLSCSEEGLPGPSDSSELVQECLQQFKVTRAQLQQIQASLLGSMEQ
Sbjct: 1 MDSIGSSGLRQGEETLSCSEEGLPGPSDSSELVQECLQQFKVTRAQLQQIQASLLGSMEQ 60
Query: 61 ALRGQASPAPAVRMLPTYVGSTPHGTEQGDFVVLELGATGASLRVLWVTLTGIEGHRVEP 120
ALRGQASPAPAVRMLPTYVGSTPHGTEQGDFVVLELGATGASLRVLWVTLTGIEGHRVEP
Sbjct: 61 ALRGQASPAPAVRMLPTYVGSTPHGTEQGDFVVLELGATGASLRVLWVTLTGIEGHRVEP 120
Query: 121 RSQEFVIPQEVMLGAGQQLFDFAAHCLSEFLDAQPVNKQGLQLGFSFSFPCHQTGLDRST 180
RSQEFVIPQEVMLGAGQQLFDFAAHCLSEFLDAQPVNKQGLQLGFSFSFPCHQTGLDRST
Sbjct: 121 RSQEFVIPQEVMLGAGQQLFDFAAHCLSEFLDAQPVNKQGLQLGFSFSFPCHQTGLDRST 180
Query: 181 LISWTKGFRCSGVEGQDVVQLLRDAIRRQGAYNIDVVAVVNDTVGTMMGCEPGVRPCEVG 240
LISWTKGFRCSGVEGQDVVQLLRDAIRRQGAYNIDVVAVVNDTVGTMMGCEPGVRPCEVG
Sbjct: 181 LISWTKGFRCSGVEGQDVVQLLRDAIRRQGAYNIDVVAVVNDTVGTMMGCEPGVRPCEVG 240
Query: 241 LVVDTGTNACYMEEARHVAVLDEDRGRVCVSVEWGSFSDDGALGPVLTTFDHTLDHESLN 300
LVVDTGTNACYMEEARHVAVLDEDRGRVCVSVEWGSFSDDGALGPVLTTFDHTLDHESLN
Sbjct: 241 LVVDTGTNACYMEEARHVAVLDEDRGRVCVSVEWGSFSDDGALGPVLTTFDHTLDHESLN 300
Query: 301 PGAQRFEKMIGGLYLGELVRLVLAHLARCGVLFGGCTSPALLSQGSILLEHVAEMEDPST 360
PGAQRFEKMIGGLYLGELVRLVLAHLARCGVLFGGCTSPALLSQGSILLEHVAEMEDPST
Sbjct: 301 PGAQRFEKMIGGLYLGELVRLVLAHLARCGVLFGGCTSPALLSQGSILLEHVAEMEDPST 360
Query: 361 GAARVHAILQDLGLSPGASDVELVQHVCAAVCTRAAQLCAAALAAVLSCLQHSREQQTLQ 420
GAARVHAILQDLGLSPGASDVELVQHVCAAVCTRAAQLCAAALAAVLSCLQHSREQQTLQ
Sbjct: 361 GAARVHAILQDLGLSPGASDVELVQHVCAAVCTRAAQLCAAALAAVLSCLQHSREQQTLQ 420
Query: 421 VAVATGGRVCERHPRFCSVLQGTVMLLAPECDVSLIPSVDGGGRGVAMVTAVAARLAAHR 480
VAVATGGRVCERHPRFCSVLQGTVMLLAPECDVSLIPSVDGGGRGVAMVTAVAARLAAHR
Sbjct: 421 VAVATGGRVCERHPRFCSVLQGTVMLLAPECDVSLIPSVDGGGRGVAMVTAVAARLAAHR 480
Query: 481 RLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGEASSLRMLPTFVRATPDGSERGDFLA 540
RLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGEASSLRMLPTFVRATPDGSERGDFLA
Sbjct: 481 RLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGEASSLRMLPTFVRATPDGSERGDFLA 540
Query: 541 LDLGGTNFRVLLVRVTTGVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQGLSGQ 600
LDLGGTNFRVLLVRVTTGVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQGLSGQ
Sbjct: 541 LDLGGTNFRVLLVRVTTGVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQGLSGQ 600
Query: 601 SLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVELNVVAI 660
SLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVELNVVAI
Sbjct: 601 SLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVELNVVAI 660
Query: 661 VNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEWGAFGD 720
VNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEWGAFGD
Sbjct: 661 VNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEWGAFGD 720
Query: 721 DGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQIQ 780
DGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQIQ
Sbjct: 721 DGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQIQ 780
Query: 781 RLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQRAAQLC 840
RLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQRAAQLC
Sbjct: 781 RLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQRAAQLC 840
Query: 841 GAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVTFLQSE 900
GAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVTFLQSE
Sbjct: 841 GAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVTFLQSE 900
Query: 901 DGSGKGAALVTAVACRLAQLTRV 923
DGSGKGAALVTAVACRLAQLTRV
Sbjct: 901 DGSGKGAALVTAVACRLAQLTRV 923
>gi|15553127 hexokinase 2 [Homo sapiens]
Length = 917
Score = 1013 bits (2620), Expect = 0.0
Identities = 506/899 (56%), Positives = 658/899 (73%), Gaps = 9/899 (1%)
Query: 28 DSSELVQECLQQFKVTRAQLQQIQASLLGSMEQALRGQASPAPAVRMLPTYVGSTPHGTE 87
D + V + L +++ L +I ME+ L P AV+MLPT+V STP GTE
Sbjct: 17 DQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTE 76
Query: 88 QGDFVVLELGATGASLRVLWVTLTGIEGHRVEPRSQEFVIPQEVMLGAGQQLFDFAAHCL 147
G+F+ L+LG G + RVLWV +T +VE +Q + IP+++M G+G QLFD A CL
Sbjct: 77 HGEFLALDLG--GTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECL 134
Query: 148 SEFLDAQPVNKQGLQLGFSFSFPCHQTGLDRSTLISWTKGFRCSGVEGQDVVQLLRDAIR 207
+ F+D + + L LGF+FSFPCHQT LD S L+SWTKGF+ SGVEG+DVV L+R AI+
Sbjct: 135 ANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQ 194
Query: 208 RQGAYNIDVVAVVNDTVGTMMGCEPGVRPCEVGLVVDTGTNACYMEEARHVAVLDEDRGR 267
R+G ++ID+VAVVNDTVGTMM C CE+GL+V TG+NACYMEE RH+ +++ D GR
Sbjct: 195 RRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGR 254
Query: 268 VCVSVEWGSFSDDGALGPVLTTFDHTLDHESLNPGAQRFEKMIGGLYLGELVRLVLAHLA 327
+C+++EWG+F DDG+L + T FD +D SLNPG Q FEKMI G+Y+GELVRL+L +A
Sbjct: 255 MCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMA 314
Query: 328 RCGVLFGGCTSPALLSQGSILLEHVAEMEDPSTGAARVHAILQDLGLSPGASDVELVQHV 387
+ +LFGG SP LL+ G + ++++E G + +L LGL P D +
Sbjct: 315 KEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRI 374
Query: 388 CAAVCTRAAQLCAAALAAVLSCLQHSREQQTLQVAVATGGRVCERHPRFCSVLQGTVMLL 447
C V TR+A LCAA LAAVL ++ ++ ++ L+ + G V ++HP F L TV L
Sbjct: 375 CQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRL 434
Query: 448 APECDVSLIPSVDGGGRGVAMVTAVAARLAAHRRLLEETLAPFRLNHDQLAAVQAQMRKA 507
P CDV + S DG G+G AMVTAVA RLA R ++TL +L+HDQL V+ +M+
Sbjct: 435 VPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVE 494
Query: 508 MAKGLRGE---ASSLRMLPTFVRATPDGSERGDFLALDLGGTNFRVLLVRVTTG----VQ 560
M +GL E ++ ++MLPT+V ATPDG+E+GDFLALDLGGTNFRVLLVRV G V+
Sbjct: 495 MERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVE 554
Query: 561 ITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQGLSGQSLPLGFTFSFPCRQLGLDQG 620
+ ++IY+IP+ V G+G +LFDHIV CI DF + G+ G SLPLGFTFSFPC+Q LD+
Sbjct: 555 MHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDES 614
Query: 621 ILLNWTKGFKASDCEGQDVVSLLREAITRRQAVELNVVAIVNDTVGTMMSCGYEDPRCEI 680
ILL WTKGFKAS CEG+DVV+LL+EAI RR+ +L+VVA+VNDTVGTMM+CG+EDP CE+
Sbjct: 615 ILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEV 674
Query: 681 GLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEWGAFGDDGSLAMLSTRFDASVDQASI 740
GLIVGTG+NACYMEE+RNV V G+ GRMC+NMEWGAFGD+G L T FD +VD+ S+
Sbjct: 675 GLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSL 734
Query: 741 NPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQIQRLQTRDIFKTKFLSEIESDS 800
NPGKQRFEKMISGMYLGEIVR+IL+ T G+LFRG+ +RL+TR IF+TKFLS+IESD
Sbjct: 735 NPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDC 794
Query: 801 LALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQRAAQLCGAGVAAVVEKIRENRGLEEL 860
LAL QVRAIL+ LGL T DD+++V EVC V++RAAQLCGAG+AAVV++IRENRGL+ L
Sbjct: 795 LALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDAL 854
Query: 861 AVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVTFLQSEDGSGKGAALVTAVACRLAQ 919
V+VGVDGTLYKLHP F+ ++ TV++LAP+C V+FLQSEDGSGKGAAL+TAVACR+ +
Sbjct: 855 KVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKGAALITAVACRIRE 913
Score = 487 bits (1253), Expect = e-137
Identities = 243/447 (54%), Positives = 323/447 (72%), Gaps = 7/447 (1%)
Query: 483 LEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGEA---SSLRMLPTFVRATPDGSERGDFL 539
+++ L RL+ + L + + RK M KGL ++++MLPTFVR+TPDG+E G+FL
Sbjct: 22 VDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFL 81
Query: 540 ALDLGGTNFRVLLVRVTTG----VQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQ 595
ALDLGGTNFRVL V+VT V++ ++IY+IPE + +GSG QLFDHI +C+ +F K
Sbjct: 82 ALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKL 141
Query: 596 GLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVEL 655
+ + LPLGFTFSFPC Q LD+ L++WTKGFK+S EG+DVV+L+R+AI RR ++
Sbjct: 142 QIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDI 201
Query: 656 NVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEW 715
++VA+VNDTVGTMM+CGY+D CEIGLIVGTG+NACYMEE+R++ V GD GRMCINMEW
Sbjct: 202 DIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEW 261
Query: 716 GAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFR 775
GAFGDDGSL + T FD +D S+NPGKQ FEKMISGMY+GE+VR IL+ + +LF
Sbjct: 262 GAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFG 321
Query: 776 GQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQR 835
G+ L F+TK +S+IE + +R+ R +L LGL T +D + +CQ VS R
Sbjct: 322 GKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQIVSTR 381
Query: 836 AAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVT 895
+A LC A +AAV+++I+EN+G E L ++GVDG++YK HP F+ + TVR L P C V
Sbjct: 382 SASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPGCDVR 441
Query: 896 FLQSEDGSGKGAALVTAVACRLAQLTR 922
FL+SEDGSGKGAA+VTAVA RLA R
Sbjct: 442 FLRSEDGSGKGAAMVTAVAYRLADQHR 468
Score = 396 bits (1017), Expect = e-110
Identities = 205/450 (45%), Positives = 288/450 (64%), Gaps = 2/450 (0%)
Query: 27 SDSSELVQECLQQFKVTRAQLQQIQASLLGSMEQALRGQASPAPAVRMLPTYVGSTPHGT 86
+D Q+ L+ +++ QL +++ + ME+ L + + V+MLPTYV +TP GT
Sbjct: 464 ADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGT 523
Query: 87 EQGDFVVLELGATGASLRVLWVTLTGIEGHRVEPRSQEFVIPQEVMLGAGQQLFDFAAHC 146
E+GDF+ L+LG G + RVL V + + VE ++ + IPQEVM G G +LFD C
Sbjct: 524 EKGDFLALDLG--GTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQC 581
Query: 147 LSEFLDAQPVNKQGLQLGFSFSFPCHQTGLDRSTLISWTKGFRCSGVEGQDVVQLLRDAI 206
+++FL+ + L LGF+FSFPC Q LD S L+ WTKGF+ SG EG+DVV LL++AI
Sbjct: 582 IADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAI 641
Query: 207 RRQGAYNIDVVAVVNDTVGTMMGCEPGVRPCEVGLVVDTGTNACYMEEARHVAVLDEDRG 266
R+ +++DVVAVVNDTVGTMM C CEVGL+V TG+NACYMEE R+V +++ + G
Sbjct: 642 HRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEG 701
Query: 267 RVCVSVEWGSFSDDGALGPVLTTFDHTLDHESLNPGAQRFEKMIGGLYLGELVRLVLAHL 326
R+CV++EWG+F D+G L T FD +D SLNPG QRFEKMI G+YLGE+VR +L
Sbjct: 702 RMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDF 761
Query: 327 ARCGVLFGGCTSPALLSQGSILLEHVAEMEDPSTGAARVHAILQDLGLSPGASDVELVQH 386
+ G+LF G S L ++G + ++++E +V AILQ LGL D +V+
Sbjct: 762 TKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKE 821
Query: 387 VCAAVCTRAAQLCAAALAAVLSCLQHSREQQTLQVAVATGGRVCERHPRFCSVLQGTVML 446
VC V RAAQLC A +AAV+ ++ +R L+V V G + + HP F V+ TV
Sbjct: 822 VCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKD 881
Query: 447 LAPECDVSLIPSVDGGGRGVAMVTAVAARL 476
LAP+CDVS + S DG G+G A++TAVA R+
Sbjct: 882 LAPKCDVSFLQSEDGSGKGAALITAVACRI 911
>gi|156151420 hexokinase domain containing 1 [Homo sapiens]
Length = 917
Score = 950 bits (2456), Expect = 0.0
Identities = 483/898 (53%), Positives = 633/898 (70%), Gaps = 8/898 (0%)
Query: 28 DSSELVQECLQQFKVTRAQLQQIQASLLGSMEQALRGQASPAPAVRMLPTYVGSTPHGTE 87
D + V L +++ L I ME+ L +P AV+MLPT+V + P G+E
Sbjct: 17 DQIKKVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAAVKMLPTFVRAIPDGSE 76
Query: 88 QGDFVVLELGATGASLRVLWVTLTGIEGHRVEPRSQEFVIPQEVMLGAGQQLFDFAAHCL 147
G+F+ L+LG G+ RVL V + V+ SQ + P E++ G G +LF++ A CL
Sbjct: 77 NGEFLSLDLG--GSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIRGNGTELFEYVADCL 134
Query: 148 SEFLDAQPVNKQGLQLGFSFSFPCHQTGLDRSTLISWTKGFRCSGVEGQDVVQLLRDAIR 207
++F+ + + + L LG +FSFPC QT L+ L+SWTK F+ GV+ DVV L A+R
Sbjct: 135 ADFMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGVQDTDVVSRLTKAMR 194
Query: 208 RQGAYNIDVVAVVNDTVGTMMGCEPGVRPCEVGLVVDTGTNACYMEEARHVAVLDEDRGR 267
R ++D++A+VNDTVGTMM C CEVG+++ TGTNACYME+ ++ +++ D GR
Sbjct: 195 RHKDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYMEDMSNIDLVEGDEGR 254
Query: 268 VCVSVEWGSFSDDGALGPVLTTFDHTLDHESLNPGAQRFEKMIGGLYLGELVRLVLAHLA 327
+C++ EWG+F DDGAL + T FD LD SLNPG Q FEKMI GLYLGELVRL+L +A
Sbjct: 255 MCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYLGELVRLILLKMA 314
Query: 328 RCGVLFGGCTSPALLSQGSILLEHVAEMEDPSTGAARVHAILQDLGLSPGASDVELVQHV 387
+ G+LFGG S AL ++G I HVA ME G A IL DLGL P +D VQHV
Sbjct: 315 KAGLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLGLEPSEADCIAVQHV 374
Query: 388 CAAVCTRAAQLCAAALAAVLSCLQHSREQQTLQVAVATGGRVCERHPRFCSVLQGTVMLL 447
C V R+A LCAAALAA+L+ L+ +++ + L+ V G + + HP++ L V L
Sbjct: 375 CTIVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIHPQYPKRLHKVVRKL 434
Query: 448 APECDVSLIPSVDGGGRGVAMVTAVAARLAAHRRLLEETLAPFRLNHDQLAAVQAQMRKA 507
P CDV + S G +G AMVTAVA+R+ A R+ ++ LA F+L +QL VQA+MR
Sbjct: 435 VPSCDVRFLLSESGSTKGAAMVTAVASRVQAQRKQIDRVLALFQLTREQLVDVQAKMRAE 494
Query: 508 MAKGLRGEASSL---RMLPTFVRATPDGSERGDFLALDLGGTNFRVLLVRVTTG---VQI 561
+ GL+ ++ L RMLPT+V PDG+E+G FLALDLGGTNFRVLLV++ +G V++
Sbjct: 495 LEYGLKKKSHGLATVRMLPTYVCGLPDGTEKGKFLALDLGGTNFRVLLVKIRSGRRSVRM 554
Query: 562 TSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQGLSGQSLPLGFTFSFPCRQLGLDQGI 621
++I++IP + QG+G++LFDHIV CI DF GL G SLPLGFTFSFPCRQ+ +D+G
Sbjct: 555 YNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGASLPLGFTFSFPCRQMSIDKGT 614
Query: 622 LLNWTKGFKASDCEGQDVVSLLREAITRRQAVELNVVAIVNDTVGTMMSCGYEDPRCEIG 681
L+ WTKGFKA+DCEG+DVV +LREAI RR +L++VA+VNDTVGTMM+CGYEDP CEIG
Sbjct: 615 LIGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVGTMMTCGYEDPNCEIG 674
Query: 682 LIVGTGTNACYMEELRNVAGVPGDSGRMCINMEWGAFGDDGSLAMLSTRFDASVDQASIN 741
LI GTG+N CYME++RN+ V G G+MCIN EWG FGD+G + + TR+D VD+ S+N
Sbjct: 675 LIAGTGSNMCYMEDMRNIEMVEGGEGKMCINTEWGGFGDNGCIDDIRTRYDTEVDEGSLN 734
Query: 742 PGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQIQRLQTRDIFKTKFLSEIESDSL 801
PGKQR+EKM SGMYLGEIVR IL+ LT G+LFRGQ +RL+TR IF+TKFLS+IESD L
Sbjct: 735 PGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLFRGQISERLRTRGIFETKFLSQIESDRL 794
Query: 802 ALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQRAAQLCGAGVAAVVEKIRENRGLEELA 861
AL QVR IL+ LGL T +D+++V EVC AVS+RAAQLCGAG+AA+VEK RE++GLE L
Sbjct: 795 ALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQLCGAGLAAIVEKRREDQGLEHLR 854
Query: 862 VSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVTFLQSEDGSGKGAALVTAVACRLAQ 919
++VGVDGTLYKLHP FS ++ TV+ELAPRC VTF+ SEDGSGKGAAL+TAVA RL Q
Sbjct: 855 ITVGVDGTLYKLHPHFSRILQETVKELAPRCDVTFMLSEDGSGKGAALITAVAKRLQQ 912
>gi|188497754 hexokinase 1 isoform HKI [Homo sapiens]
Length = 917
Score = 945 bits (2443), Expect = 0.0
Identities = 479/897 (53%), Positives = 631/897 (70%), Gaps = 9/897 (1%)
Query: 28 DSSELVQECLQQFKVTRAQLQQIQASLLGSMEQALRGQASPAPAVRMLPTYVGSTPHGTE 87
D + + + L +++ L I M+ L +P V+MLPT+V S P G+E
Sbjct: 17 DQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSE 76
Query: 88 QGDFVVLELGATGASLRVLWVTLTGIEGHRVEPRSQEFVIPQEVMLGAGQQLFDFAAHCL 147
+GDF+ L+LG G+S R+L V + + V S+ + P+ ++ G+G QLFD A CL
Sbjct: 77 KGDFIALDLG--GSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECL 134
Query: 148 SEFLDAQPVNKQGLQLGFSFSFPCHQTGLDRSTLISWTKGFRCSGVEGQDVVQLLRDAIR 207
+F++ + + + L +GF+FSFPC Q+ +D + LI+WTK F+ SGVEG DVV+LL AI+
Sbjct: 135 GDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIK 194
Query: 208 RQGAYNIDVVAVVNDTVGTMMGCEPGVRPCEVGLVVDTGTNACYMEEARHVAVLDEDRGR 267
++G Y+ ++VAVVNDTVGTMM C + CEVGL++ TGTNACYMEE RH+ +++ D GR
Sbjct: 195 KRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGR 254
Query: 268 VCVSVEWGSFSDDGALGPVLTTFDHTLDHESLNPGAQRFEKMIGGLYLGELVRLVLAHLA 327
+C++ EWG+F DDG+L + T FD +D SLNPG Q FEKM+ G+YLGELVRL+L +A
Sbjct: 255 MCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMA 314
Query: 328 RCGVLFGGCTSPALLSQGSILLEHVAEMEDPSTGAARVHAILQDLGLSPGASDVELVQHV 387
+ G+LF G +P LL++G V+ +E G IL LG+ P D VQHV
Sbjct: 315 KEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHV 374
Query: 388 CAAVCTRAAQLCAAALAAVLSCLQHSREQQTLQVAVATGGRVCERHPRFCSVLQGTVMLL 447
C V R+A L AA L A+L+ L+ ++ L+ V G + + HP++ T+ L
Sbjct: 375 CTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRL 434
Query: 448 APECDVSLIPSVDGGGRGVAMVTAVAARLAAHRRLLEETLAPFRLNHDQLAAVQAQMRKA 507
P+ DV + S G G+G AMVTAVA RLA R +EETLA F L D L V+ +MR
Sbjct: 435 VPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAE 494
Query: 508 MAKGLRGEASS---LRMLPTFVRATPDGSERGDFLALDLGGTNFRVLLVRVTTG----VQ 560
M GLR + + ++MLP+FVR TPDG+E GDFLALDLGGTNFRVLLV++ +G V+
Sbjct: 495 MELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVE 554
Query: 561 ITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQGLSGQSLPLGFTFSFPCRQLGLDQG 620
+ ++IY+IP + QG+G++LFDHIV CI DF G+ G +PLGFTFSFPC+Q LD G
Sbjct: 555 MHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAG 614
Query: 621 ILLNWTKGFKASDCEGQDVVSLLREAITRRQAVELNVVAIVNDTVGTMMSCGYEDPRCEI 680
IL+ WTKGFKA+DC G DVV+LLR+AI RR+ +L+VVA+VNDTVGTMM+C YE+P CE+
Sbjct: 615 ILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEV 674
Query: 681 GLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEWGAFGDDGSLAMLSTRFDASVDQASI 740
GLIVGTG+NACYMEE++NV V GD G+MCINMEWGAFGD+G L + T +D VD+ S+
Sbjct: 675 GLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSL 734
Query: 741 NPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQIQRLQTRDIFKTKFLSEIESDS 800
N GKQR+EKMISGMYLGEIVR+IL+ T G LFRGQ + L+TR IF+TKFLS+IESD
Sbjct: 735 NAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDR 794
Query: 801 LALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQRAAQLCGAGVAAVVEKIRENRGLEEL 860
LAL QVRAIL+ LGL T DD+++V VC VS+RAAQLCGAG+AAVV+KIRENRGL+ L
Sbjct: 795 LALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRL 854
Query: 861 AVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVTFLQSEDGSGKGAALVTAVACRL 917
V+VGVDGTLYKLHP FS ++ TV+EL+P+C V+FL SEDGSGKGAAL+TAV RL
Sbjct: 855 NVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRL 911
Score = 463 bits (1192), Expect = e-130
Identities = 232/447 (51%), Positives = 308/447 (68%), Gaps = 7/447 (1%)
Query: 483 LEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGE---ASSLRMLPTFVRATPDGSERGDFL 539
+++ L RL+ + L + + RK M GL + ++++MLPTFVR+ PDGSE+GDF+
Sbjct: 22 IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 81
Query: 540 ALDLGGTNFRVLLVRVT----TGVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQ 595
ALDLGG++FR+L V+V V + SE+Y PE + GSG QLFDH+ +C+ DF +K+
Sbjct: 82 ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 141
Query: 596 GLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVEL 655
+ + LP+GFTFSFPC+Q +D+ IL+ WTK FKAS EG DVV LL +AI +R +
Sbjct: 142 KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA 201
Query: 656 NVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEW 715
N+VA+VNDTVGTMM+CGY+D CE+GLI+GTGTNACYMEELR++ V GD GRMCIN EW
Sbjct: 202 NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW 261
Query: 716 GAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFR 775
GAFGDDGSL + T FD +D+ S+NPGKQ FEKM+SGMYLGE+VR IL+ + G+LF
Sbjct: 262 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 321
Query: 776 GQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQR 835
G+ L TR F T +S IE + L + IL LG+ + DD + V VC VS R
Sbjct: 322 GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR 381
Query: 836 AAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVT 895
+A L A + A++ ++R+N+G L +VGVDG+LYK HP++S T+R L P V
Sbjct: 382 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR 441
Query: 896 FLQSEDGSGKGAALVTAVACRLAQLTR 922
FL SE GSGKGAA+VTAVA RLA+ R
Sbjct: 442 FLLSESGSGKGAAMVTAVAYRLAEQHR 468
>gi|188497750 hexokinase 1 isoform HKI-td [Homo sapiens]
Length = 905
Score = 945 bits (2442), Expect = 0.0
Identities = 478/894 (53%), Positives = 630/894 (70%), Gaps = 9/894 (1%)
Query: 31 ELVQECLQQFKVTRAQLQQIQASLLGSMEQALRGQASPAPAVRMLPTYVGSTPHGTEQGD 90
+ + + L +++ L I M+ L +P V+MLPT+V S P G+E+GD
Sbjct: 8 DFIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGD 67
Query: 91 FVVLELGATGASLRVLWVTLTGIEGHRVEPRSQEFVIPQEVMLGAGQQLFDFAAHCLSEF 150
F+ L+LG G+S R+L V + + V S+ + P+ ++ G+G QLFD A CL +F
Sbjct: 68 FIALDLG--GSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDF 125
Query: 151 LDAQPVNKQGLQLGFSFSFPCHQTGLDRSTLISWTKGFRCSGVEGQDVVQLLRDAIRRQG 210
++ + + + L +GF+FSFPC Q+ +D + LI+WTK F+ SGVEG DVV+LL AI+++G
Sbjct: 126 MEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRG 185
Query: 211 AYNIDVVAVVNDTVGTMMGCEPGVRPCEVGLVVDTGTNACYMEEARHVAVLDEDRGRVCV 270
Y+ ++VAVVNDTVGTMM C + CEVGL++ TGTNACYMEE RH+ +++ D GR+C+
Sbjct: 186 DYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCI 245
Query: 271 SVEWGSFSDDGALGPVLTTFDHTLDHESLNPGAQRFEKMIGGLYLGELVRLVLAHLARCG 330
+ EWG+F DDG+L + T FD +D SLNPG Q FEKM+ G+YLGELVRL+L +A+ G
Sbjct: 246 NTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEG 305
Query: 331 VLFGGCTSPALLSQGSILLEHVAEMEDPSTGAARVHAILQDLGLSPGASDVELVQHVCAA 390
+LF G +P LL++G V+ +E G IL LG+ P D VQHVC
Sbjct: 306 LLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTI 365
Query: 391 VCTRAAQLCAAALAAVLSCLQHSREQQTLQVAVATGGRVCERHPRFCSVLQGTVMLLAPE 450
V R+A L AA L A+L+ L+ ++ L+ V G + + HP++ T+ L P+
Sbjct: 366 VSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPD 425
Query: 451 CDVSLIPSVDGGGRGVAMVTAVAARLAAHRRLLEETLAPFRLNHDQLAAVQAQMRKAMAK 510
DV + S G G+G AMVTAVA RLA R +EETLA F L D L V+ +MR M
Sbjct: 426 SDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMEL 485
Query: 511 GLRGEASS---LRMLPTFVRATPDGSERGDFLALDLGGTNFRVLLVRVTTG----VQITS 563
GLR + + ++MLP+FVR TPDG+E GDFLALDLGGTNFRVLLV++ +G V++ +
Sbjct: 486 GLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHN 545
Query: 564 EIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQGLSGQSLPLGFTFSFPCRQLGLDQGILL 623
+IY+IP + QG+G++LFDHIV CI DF G+ G +PLGFTFSFPC+Q LD GIL+
Sbjct: 546 KIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILI 605
Query: 624 NWTKGFKASDCEGQDVVSLLREAITRRQAVELNVVAIVNDTVGTMMSCGYEDPRCEIGLI 683
WTKGFKA+DC G DVV+LLR+AI RR+ +L+VVA+VNDTVGTMM+C YE+P CE+GLI
Sbjct: 606 TWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLI 665
Query: 684 VGTGTNACYMEELRNVAGVPGDSGRMCINMEWGAFGDDGSLAMLSTRFDASVDQASINPG 743
VGTG+NACYMEE++NV V GD G+MCINMEWGAFGD+G L + T +D VD+ S+N G
Sbjct: 666 VGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAG 725
Query: 744 KQRFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQIQRLQTRDIFKTKFLSEIESDSLAL 803
KQR+EKMISGMYLGEIVR+IL+ T G LFRGQ + L+TR IF+TKFLS+IESD LAL
Sbjct: 726 KQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLAL 785
Query: 804 RQVRAILEDLGLPLTSDDALMVLEVCQAVSQRAAQLCGAGVAAVVEKIRENRGLEELAVS 863
QVRAIL+ LGL T DD+++V VC VS+RAAQLCGAG+AAVV+KIRENRGL+ L V+
Sbjct: 786 LQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVT 845
Query: 864 VGVDGTLYKLHPRFSSLVAATVRELAPRCVVTFLQSEDGSGKGAALVTAVACRL 917
VGVDGTLYKLHP FS ++ TV+EL+P+C V+FL SEDGSGKGAAL+TAV RL
Sbjct: 846 VGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRL 899
Score = 464 bits (1193), Expect = e-130
Identities = 235/456 (51%), Positives = 312/456 (68%), Gaps = 8/456 (1%)
Query: 474 ARLAAHRRLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGE---ASSLRMLPTFVRATP 530
A+ A H +++ L RL+ + L + + RK M GL + ++++MLPTFVR+ P
Sbjct: 2 AKRALHD-FIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIP 60
Query: 531 DGSERGDFLALDLGGTNFRVLLVRVT----TGVQITSEIYSIPETVAQGSGQQLFDHIVD 586
DGSE+GDF+ALDLGG++FR+L V+V V + SE+Y PE + GSG QLFDH+ +
Sbjct: 61 DGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAE 120
Query: 587 CIVDFQQKQGLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREA 646
C+ DF +K+ + + LP+GFTFSFPC+Q +D+ IL+ WTK FKAS EG DVV LL +A
Sbjct: 121 CLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKA 180
Query: 647 ITRRQAVELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDS 706
I +R + N+VA+VNDTVGTMM+CGY+D CE+GLI+GTGTNACYMEELR++ V GD
Sbjct: 181 IKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDE 240
Query: 707 GRMCINMEWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLH 766
GRMCIN EWGAFGDDGSL + T FD +D+ S+NPGKQ FEKM+SGMYLGE+VR IL+
Sbjct: 241 GRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVK 300
Query: 767 LTSLGVLFRGQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVL 826
+ G+LF G+ L TR F T +S IE + L + IL LG+ + DD + V
Sbjct: 301 MAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQ 360
Query: 827 EVCQAVSQRAAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVR 886
VC VS R+A L A + A++ ++R+N+G L +VGVDG+LYK HP++S T+R
Sbjct: 361 HVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLR 420
Query: 887 ELAPRCVVTFLQSEDGSGKGAALVTAVACRLAQLTR 922
L P V FL SE GSGKGAA+VTAVA RLA+ R
Sbjct: 421 RLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHR 456
>gi|15991829 hexokinase 1 isoform HKI-ta/tb [Homo sapiens]
Length = 921
Score = 944 bits (2440), Expect = 0.0
Identities = 478/892 (53%), Positives = 629/892 (70%), Gaps = 9/892 (1%)
Query: 33 VQECLQQFKVTRAQLQQIQASLLGSMEQALRGQASPAPAVRMLPTYVGSTPHGTEQGDFV 92
+ + L +++ L I M+ L +P V+MLPT+V S P G+E+GDF+
Sbjct: 26 IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 85
Query: 93 VLELGATGASLRVLWVTLTGIEGHRVEPRSQEFVIPQEVMLGAGQQLFDFAAHCLSEFLD 152
L+LG G+S R+L V + + V S+ + P+ ++ G+G QLFD A CL +F++
Sbjct: 86 ALDLG--GSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFME 143
Query: 153 AQPVNKQGLQLGFSFSFPCHQTGLDRSTLISWTKGFRCSGVEGQDVVQLLRDAIRRQGAY 212
+ + + L +GF+FSFPC Q+ +D + LI+WTK F+ SGVEG DVV+LL AI+++G Y
Sbjct: 144 KRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDY 203
Query: 213 NIDVVAVVNDTVGTMMGCEPGVRPCEVGLVVDTGTNACYMEEARHVAVLDEDRGRVCVSV 272
+ ++VAVVNDTVGTMM C + CEVGL++ TGTNACYMEE RH+ +++ D GR+C++
Sbjct: 204 DANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINT 263
Query: 273 EWGSFSDDGALGPVLTTFDHTLDHESLNPGAQRFEKMIGGLYLGELVRLVLAHLARCGVL 332
EWG+F DDG+L + T FD +D SLNPG Q FEKM+ G+YLGELVRL+L +A+ G+L
Sbjct: 264 EWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLL 323
Query: 333 FGGCTSPALLSQGSILLEHVAEMEDPSTGAARVHAILQDLGLSPGASDVELVQHVCAAVC 392
F G +P LL++G V+ +E G IL LG+ P D VQHVC V
Sbjct: 324 FEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVS 383
Query: 393 TRAAQLCAAALAAVLSCLQHSREQQTLQVAVATGGRVCERHPRFCSVLQGTVMLLAPECD 452
R+A L AA L A+L+ L+ ++ L+ V G + + HP++ T+ L P+ D
Sbjct: 384 FRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSD 443
Query: 453 VSLIPSVDGGGRGVAMVTAVAARLAAHRRLLEETLAPFRLNHDQLAAVQAQMRKAMAKGL 512
V + S G G+G AMVTAVA RLA R +EETLA F L D L V+ +MR M GL
Sbjct: 444 VRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGL 503
Query: 513 RGEASS---LRMLPTFVRATPDGSERGDFLALDLGGTNFRVLLVRVTTG----VQITSEI 565
R + + ++MLP+FVR TPDG+E GDFLALDLGGTNFRVLLV++ +G V++ ++I
Sbjct: 504 RKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKI 563
Query: 566 YSIPETVAQGSGQQLFDHIVDCIVDFQQKQGLSGQSLPLGFTFSFPCRQLGLDQGILLNW 625
Y+IP + QG+G++LFDHIV CI DF G+ G +PLGFTFSFPC+Q LD GIL+ W
Sbjct: 564 YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITW 623
Query: 626 TKGFKASDCEGQDVVSLLREAITRRQAVELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVG 685
TKGFKA+DC G DVV+LLR+AI RR+ +L+VVA+VNDTVGTMM+C YE+P CE+GLIVG
Sbjct: 624 TKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVG 683
Query: 686 TGTNACYMEELRNVAGVPGDSGRMCINMEWGAFGDDGSLAMLSTRFDASVDQASINPGKQ 745
TG+NACYMEE++NV V GD G+MCINMEWGAFGD+G L + T +D VD+ S+N GKQ
Sbjct: 684 TGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQ 743
Query: 746 RFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQIQRLQTRDIFKTKFLSEIESDSLALRQ 805
R+EKMISGMYLGEIVR+IL+ T G LFRGQ + L+TR IF+TKFLS+IESD LAL Q
Sbjct: 744 RYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQ 803
Query: 806 VRAILEDLGLPLTSDDALMVLEVCQAVSQRAAQLCGAGVAAVVEKIRENRGLEELAVSVG 865
VRAIL+ LGL T DD+++V VC VS+RAAQLCGAG+AAVV+KIRENRGL+ L V+VG
Sbjct: 804 VRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVG 863
Query: 866 VDGTLYKLHPRFSSLVAATVRELAPRCVVTFLQSEDGSGKGAALVTAVACRL 917
VDGTLYKLHP FS ++ TV+EL+P+C V+FL SEDGSGKGAAL+TAV RL
Sbjct: 864 VDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRL 915
Score = 463 bits (1192), Expect = e-130
Identities = 232/447 (51%), Positives = 308/447 (68%), Gaps = 7/447 (1%)
Query: 483 LEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGE---ASSLRMLPTFVRATPDGSERGDFL 539
+++ L RL+ + L + + RK M GL + ++++MLPTFVR+ PDGSE+GDF+
Sbjct: 26 IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 85
Query: 540 ALDLGGTNFRVLLVRVT----TGVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQ 595
ALDLGG++FR+L V+V V + SE+Y PE + GSG QLFDH+ +C+ DF +K+
Sbjct: 86 ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 145
Query: 596 GLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVEL 655
+ + LP+GFTFSFPC+Q +D+ IL+ WTK FKAS EG DVV LL +AI +R +
Sbjct: 146 KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA 205
Query: 656 NVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEW 715
N+VA+VNDTVGTMM+CGY+D CE+GLI+GTGTNACYMEELR++ V GD GRMCIN EW
Sbjct: 206 NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW 265
Query: 716 GAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFR 775
GAFGDDGSL + T FD +D+ S+NPGKQ FEKM+SGMYLGE+VR IL+ + G+LF
Sbjct: 266 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 325
Query: 776 GQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQR 835
G+ L TR F T +S IE + L + IL LG+ + DD + V VC VS R
Sbjct: 326 GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR 385
Query: 836 AAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVT 895
+A L A + A++ ++R+N+G L +VGVDG+LYK HP++S T+R L P V
Sbjct: 386 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR 445
Query: 896 FLQSEDGSGKGAALVTAVACRLAQLTR 922
FL SE GSGKGAA+VTAVA RLA+ R
Sbjct: 446 FLLSESGSGKGAAMVTAVAYRLAEQHR 472
>gi|15991831 hexokinase 1 isoform HKI-ta/tb [Homo sapiens]
Length = 921
Score = 944 bits (2440), Expect = 0.0
Identities = 478/892 (53%), Positives = 629/892 (70%), Gaps = 9/892 (1%)
Query: 33 VQECLQQFKVTRAQLQQIQASLLGSMEQALRGQASPAPAVRMLPTYVGSTPHGTEQGDFV 92
+ + L +++ L I M+ L +P V+MLPT+V S P G+E+GDF+
Sbjct: 26 IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 85
Query: 93 VLELGATGASLRVLWVTLTGIEGHRVEPRSQEFVIPQEVMLGAGQQLFDFAAHCLSEFLD 152
L+LG G+S R+L V + + V S+ + P+ ++ G+G QLFD A CL +F++
Sbjct: 86 ALDLG--GSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFME 143
Query: 153 AQPVNKQGLQLGFSFSFPCHQTGLDRSTLISWTKGFRCSGVEGQDVVQLLRDAIRRQGAY 212
+ + + L +GF+FSFPC Q+ +D + LI+WTK F+ SGVEG DVV+LL AI+++G Y
Sbjct: 144 KRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDY 203
Query: 213 NIDVVAVVNDTVGTMMGCEPGVRPCEVGLVVDTGTNACYMEEARHVAVLDEDRGRVCVSV 272
+ ++VAVVNDTVGTMM C + CEVGL++ TGTNACYMEE RH+ +++ D GR+C++
Sbjct: 204 DANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINT 263
Query: 273 EWGSFSDDGALGPVLTTFDHTLDHESLNPGAQRFEKMIGGLYLGELVRLVLAHLARCGVL 332
EWG+F DDG+L + T FD +D SLNPG Q FEKM+ G+YLGELVRL+L +A+ G+L
Sbjct: 264 EWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLL 323
Query: 333 FGGCTSPALLSQGSILLEHVAEMEDPSTGAARVHAILQDLGLSPGASDVELVQHVCAAVC 392
F G +P LL++G V+ +E G IL LG+ P D VQHVC V
Sbjct: 324 FEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVS 383
Query: 393 TRAAQLCAAALAAVLSCLQHSREQQTLQVAVATGGRVCERHPRFCSVLQGTVMLLAPECD 452
R+A L AA L A+L+ L+ ++ L+ V G + + HP++ T+ L P+ D
Sbjct: 384 FRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSD 443
Query: 453 VSLIPSVDGGGRGVAMVTAVAARLAAHRRLLEETLAPFRLNHDQLAAVQAQMRKAMAKGL 512
V + S G G+G AMVTAVA RLA R +EETLA F L D L V+ +MR M GL
Sbjct: 444 VRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGL 503
Query: 513 RGEASS---LRMLPTFVRATPDGSERGDFLALDLGGTNFRVLLVRVTTG----VQITSEI 565
R + + ++MLP+FVR TPDG+E GDFLALDLGGTNFRVLLV++ +G V++ ++I
Sbjct: 504 RKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKI 563
Query: 566 YSIPETVAQGSGQQLFDHIVDCIVDFQQKQGLSGQSLPLGFTFSFPCRQLGLDQGILLNW 625
Y+IP + QG+G++LFDHIV CI DF G+ G +PLGFTFSFPC+Q LD GIL+ W
Sbjct: 564 YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITW 623
Query: 626 TKGFKASDCEGQDVVSLLREAITRRQAVELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVG 685
TKGFKA+DC G DVV+LLR+AI RR+ +L+VVA+VNDTVGTMM+C YE+P CE+GLIVG
Sbjct: 624 TKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVG 683
Query: 686 TGTNACYMEELRNVAGVPGDSGRMCINMEWGAFGDDGSLAMLSTRFDASVDQASINPGKQ 745
TG+NACYMEE++NV V GD G+MCINMEWGAFGD+G L + T +D VD+ S+N GKQ
Sbjct: 684 TGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQ 743
Query: 746 RFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQIQRLQTRDIFKTKFLSEIESDSLALRQ 805
R+EKMISGMYLGEIVR+IL+ T G LFRGQ + L+TR IF+TKFLS+IESD LAL Q
Sbjct: 744 RYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQ 803
Query: 806 VRAILEDLGLPLTSDDALMVLEVCQAVSQRAAQLCGAGVAAVVEKIRENRGLEELAVSVG 865
VRAIL+ LGL T DD+++V VC VS+RAAQLCGAG+AAVV+KIRENRGL+ L V+VG
Sbjct: 804 VRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVG 863
Query: 866 VDGTLYKLHPRFSSLVAATVRELAPRCVVTFLQSEDGSGKGAALVTAVACRL 917
VDGTLYKLHP FS ++ TV+EL+P+C V+FL SEDGSGKGAAL+TAV RL
Sbjct: 864 VDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRL 915
Score = 463 bits (1192), Expect = e-130
Identities = 232/447 (51%), Positives = 308/447 (68%), Gaps = 7/447 (1%)
Query: 483 LEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGE---ASSLRMLPTFVRATPDGSERGDFL 539
+++ L RL+ + L + + RK M GL + ++++MLPTFVR+ PDGSE+GDF+
Sbjct: 26 IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 85
Query: 540 ALDLGGTNFRVLLVRVT----TGVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQ 595
ALDLGG++FR+L V+V V + SE+Y PE + GSG QLFDH+ +C+ DF +K+
Sbjct: 86 ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 145
Query: 596 GLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVEL 655
+ + LP+GFTFSFPC+Q +D+ IL+ WTK FKAS EG DVV LL +AI +R +
Sbjct: 146 KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA 205
Query: 656 NVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEW 715
N+VA+VNDTVGTMM+CGY+D CE+GLI+GTGTNACYMEELR++ V GD GRMCIN EW
Sbjct: 206 NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW 265
Query: 716 GAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFR 775
GAFGDDGSL + T FD +D+ S+NPGKQ FEKM+SGMYLGE+VR IL+ + G+LF
Sbjct: 266 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 325
Query: 776 GQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQR 835
G+ L TR F T +S IE + L + IL LG+ + DD + V VC VS R
Sbjct: 326 GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR 385
Query: 836 AAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVT 895
+A L A + A++ ++R+N+G L +VGVDG+LYK HP++S T+R L P V
Sbjct: 386 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR 445
Query: 896 FLQSEDGSGKGAALVTAVACRLAQLTR 922
FL SE GSGKGAA+VTAVA RLA+ R
Sbjct: 446 FLLSESGSGKGAAMVTAVAYRLAEQHR 472
>gi|15991827 hexokinase 1 isoform HKI-R [Homo sapiens]
Length = 916
Score = 944 bits (2440), Expect = 0.0
Identities = 478/892 (53%), Positives = 629/892 (70%), Gaps = 9/892 (1%)
Query: 33 VQECLQQFKVTRAQLQQIQASLLGSMEQALRGQASPAPAVRMLPTYVGSTPHGTEQGDFV 92
+ + L +++ L I M+ L +P V+MLPT+V S P G+E+GDF+
Sbjct: 21 IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 80
Query: 93 VLELGATGASLRVLWVTLTGIEGHRVEPRSQEFVIPQEVMLGAGQQLFDFAAHCLSEFLD 152
L+LG G+S R+L V + + V S+ + P+ ++ G+G QLFD A CL +F++
Sbjct: 81 ALDLG--GSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFME 138
Query: 153 AQPVNKQGLQLGFSFSFPCHQTGLDRSTLISWTKGFRCSGVEGQDVVQLLRDAIRRQGAY 212
+ + + L +GF+FSFPC Q+ +D + LI+WTK F+ SGVEG DVV+LL AI+++G Y
Sbjct: 139 KRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDY 198
Query: 213 NIDVVAVVNDTVGTMMGCEPGVRPCEVGLVVDTGTNACYMEEARHVAVLDEDRGRVCVSV 272
+ ++VAVVNDTVGTMM C + CEVGL++ TGTNACYMEE RH+ +++ D GR+C++
Sbjct: 199 DANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINT 258
Query: 273 EWGSFSDDGALGPVLTTFDHTLDHESLNPGAQRFEKMIGGLYLGELVRLVLAHLARCGVL 332
EWG+F DDG+L + T FD +D SLNPG Q FEKM+ G+YLGELVRL+L +A+ G+L
Sbjct: 259 EWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLL 318
Query: 333 FGGCTSPALLSQGSILLEHVAEMEDPSTGAARVHAILQDLGLSPGASDVELVQHVCAAVC 392
F G +P LL++G V+ +E G IL LG+ P D VQHVC V
Sbjct: 319 FEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVS 378
Query: 393 TRAAQLCAAALAAVLSCLQHSREQQTLQVAVATGGRVCERHPRFCSVLQGTVMLLAPECD 452
R+A L AA L A+L+ L+ ++ L+ V G + + HP++ T+ L P+ D
Sbjct: 379 FRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSD 438
Query: 453 VSLIPSVDGGGRGVAMVTAVAARLAAHRRLLEETLAPFRLNHDQLAAVQAQMRKAMAKGL 512
V + S G G+G AMVTAVA RLA R +EETLA F L D L V+ +MR M GL
Sbjct: 439 VRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGL 498
Query: 513 RGEASS---LRMLPTFVRATPDGSERGDFLALDLGGTNFRVLLVRVTTG----VQITSEI 565
R + + ++MLP+FVR TPDG+E GDFLALDLGGTNFRVLLV++ +G V++ ++I
Sbjct: 499 RKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKI 558
Query: 566 YSIPETVAQGSGQQLFDHIVDCIVDFQQKQGLSGQSLPLGFTFSFPCRQLGLDQGILLNW 625
Y+IP + QG+G++LFDHIV CI DF G+ G +PLGFTFSFPC+Q LD GIL+ W
Sbjct: 559 YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITW 618
Query: 626 TKGFKASDCEGQDVVSLLREAITRRQAVELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVG 685
TKGFKA+DC G DVV+LLR+AI RR+ +L+VVA+VNDTVGTMM+C YE+P CE+GLIVG
Sbjct: 619 TKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVG 678
Query: 686 TGTNACYMEELRNVAGVPGDSGRMCINMEWGAFGDDGSLAMLSTRFDASVDQASINPGKQ 745
TG+NACYMEE++NV V GD G+MCINMEWGAFGD+G L + T +D VD+ S+N GKQ
Sbjct: 679 TGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQ 738
Query: 746 RFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQIQRLQTRDIFKTKFLSEIESDSLALRQ 805
R+EKMISGMYLGEIVR+IL+ T G LFRGQ + L+TR IF+TKFLS+IESD LAL Q
Sbjct: 739 RYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQ 798
Query: 806 VRAILEDLGLPLTSDDALMVLEVCQAVSQRAAQLCGAGVAAVVEKIRENRGLEELAVSVG 865
VRAIL+ LGL T DD+++V VC VS+RAAQLCGAG+AAVV+KIRENRGL+ L V+VG
Sbjct: 799 VRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVG 858
Query: 866 VDGTLYKLHPRFSSLVAATVRELAPRCVVTFLQSEDGSGKGAALVTAVACRL 917
VDGTLYKLHP FS ++ TV+EL+P+C V+FL SEDGSGKGAAL+TAV RL
Sbjct: 859 VDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRL 910
Score = 463 bits (1192), Expect = e-130
Identities = 232/447 (51%), Positives = 308/447 (68%), Gaps = 7/447 (1%)
Query: 483 LEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGE---ASSLRMLPTFVRATPDGSERGDFL 539
+++ L RL+ + L + + RK M GL + ++++MLPTFVR+ PDGSE+GDF+
Sbjct: 21 IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 80
Query: 540 ALDLGGTNFRVLLVRVT----TGVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQ 595
ALDLGG++FR+L V+V V + SE+Y PE + GSG QLFDH+ +C+ DF +K+
Sbjct: 81 ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 140
Query: 596 GLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVEL 655
+ + LP+GFTFSFPC+Q +D+ IL+ WTK FKAS EG DVV LL +AI +R +
Sbjct: 141 KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA 200
Query: 656 NVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEW 715
N+VA+VNDTVGTMM+CGY+D CE+GLI+GTGTNACYMEELR++ V GD GRMCIN EW
Sbjct: 201 NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW 260
Query: 716 GAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFR 775
GAFGDDGSL + T FD +D+ S+NPGKQ FEKM+SGMYLGE+VR IL+ + G+LF
Sbjct: 261 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 320
Query: 776 GQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQR 835
G+ L TR F T +S IE + L + IL LG+ + DD + V VC VS R
Sbjct: 321 GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR 380
Query: 836 AAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVT 895
+A L A + A++ ++R+N+G L +VGVDG+LYK HP++S T+R L P V
Sbjct: 381 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR 440
Query: 896 FLQSEDGSGKGAALVTAVACRLAQLTR 922
FL SE GSGKGAA+VTAVA RLA+ R
Sbjct: 441 FLLSESGSGKGAAMVTAVAYRLAEQHR 467
>gi|4503951 glucokinase isoform 1 [Homo sapiens]
Length = 465
Score = 475 bits (1223), Expect = e-134
Identities = 237/451 (52%), Positives = 324/451 (71%), Gaps = 9/451 (1%)
Query: 477 AAHRRLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLR---GEASSLRMLPTFVRATPDGS 533
AA + +E+ LA F+L + L V +M+K M +GLR E +S++MLPT+VR+TP+GS
Sbjct: 10 AAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGS 69
Query: 534 ERGDFLALDLGGTNFRVLLVRVTTG------VQITSEIYSIPETVAQGSGQQLFDHIVDC 587
E GDFL+LDLGGTNFRV+LV+V G V+ ++YSIPE G+ + LFD+I +C
Sbjct: 70 EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISEC 129
Query: 588 IVDFQQKQGLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAI 647
I DF K + + LPLGFTFSFP R +D+GILLNWTKGFKAS EG +VV LLR+AI
Sbjct: 130 ISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAI 189
Query: 648 TRRQAVELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSG 707
RR E++VVA+VNDTV TM+SC YED +CE+G+IVGTG NACYMEE++NV V GD G
Sbjct: 190 KRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEG 249
Query: 708 RMCINMEWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHL 767
RMC+N EWGAFGD G L +D VD++S NPG+Q +EK+I G Y+GE+VR +LL L
Sbjct: 250 RMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRL 309
Query: 768 TSLGVLFRGQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLE 827
+LF G+ ++L+TR F+T+F+S++ESD+ +Q+ IL LGL ++ D +V
Sbjct: 310 VDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRR 369
Query: 828 VCQAVSQRAAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRE 887
C++VS RAA +C AG+A V+ ++RE+R + + ++VGVDG++YKLHP F A+VR
Sbjct: 370 ACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR 429
Query: 888 LAPRCVVTFLQSEDGSGKGAALVTAVACRLA 918
L P C +TF++SE+GSG+GAALV+AVAC+ A
Sbjct: 430 LTPSCEITFIESEEGSGRGAALVSAVACKKA 460
Score = 374 bits (961), Expect = e-103
Identities = 189/449 (42%), Positives = 284/449 (63%), Gaps = 4/449 (0%)
Query: 31 ELVQECLQQFKVTRAQLQQIQASLLGSMEQALRGQASPAPAVRMLPTYVGSTPHGTEQGD 90
E V++ L +F++ L+++ + M++ LR + +V+MLPTYV STP G+E GD
Sbjct: 14 EKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGD 73
Query: 91 FVVLELGATGASLRVLWVTL-TGIEGH-RVEPRSQEFVIPQEVMLGAGQQLFDFAAHCLS 148
F+ L+LG G + RV+ V + G EG V+ + Q + IP++ M G + LFD+ + C+S
Sbjct: 74 FLSLDLG--GTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECIS 131
Query: 149 EFLDAQPVNKQGLQLGFSFSFPCHQTGLDRSTLISWTKGFRCSGVEGQDVVQLLRDAIRR 208
+FLD + + L LGF+FSFP +D+ L++WTKGF+ SG EG +VV LLRDAI+R
Sbjct: 132 DFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKR 191
Query: 209 QGAYNIDVVAVVNDTVGTMMGCEPGVRPCEVGLVVDTGTNACYMEEARHVAVLDEDRGRV 268
+G + +DVVA+VNDTV TM+ C CEVG++V TG NACYMEE ++V +++ D GR+
Sbjct: 192 RGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRM 251
Query: 269 CVSVEWGSFSDDGALGPVLTTFDHTLDHESLNPGAQRFEKMIGGLYLGELVRLVLAHLAR 328
CV+ EWG+F D G L L +D +D S NPG Q +EK+IGG Y+GELVRLVL L
Sbjct: 252 CVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVD 311
Query: 329 CGVLFGGCTSPALLSQGSILLEHVAEMEDPSTGAARVHAILQDLGLSPGASDVELVQHVC 388
+LF G S L ++G+ V+++E + +++ IL LGL P +D ++V+ C
Sbjct: 312 ENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRAC 371
Query: 389 AAVCTRAAQLCAAALAAVLSCLQHSREQQTLQVAVATGGRVCERHPRFCSVLQGTVMLLA 448
+V TRAA +C+A LA V++ ++ SR + +++ V G V + HP F +V L
Sbjct: 372 ESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLT 431
Query: 449 PECDVSLIPSVDGGGRGVAMVTAVAARLA 477
P C+++ I S +G GRG A+V+AVA + A
Sbjct: 432 PSCEITFIESEEGSGRGAALVSAVACKKA 460
>gi|15967159 glucokinase isoform 2 [Homo sapiens]
Length = 466
Score = 474 bits (1220), Expect = e-133
Identities = 236/446 (52%), Positives = 322/446 (72%), Gaps = 9/446 (2%)
Query: 482 LLEETLAPFRLNHDQLAAVQAQMRKAMAKGLR---GEASSLRMLPTFVRATPDGSERGDF 538
L+E+ LA F+L + L V +M+K M +GLR E +S++MLPT+VR+TP+GSE GDF
Sbjct: 16 LVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDF 75
Query: 539 LALDLGGTNFRVLLVRVTTG------VQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQ 592
L+LDLGGTNFRV+LV+V G V+ ++YSIPE G+ + LFD+I +CI DF
Sbjct: 76 LSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFL 135
Query: 593 QKQGLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQA 652
K + + LPLGFTFSFP R +D+GILLNWTKGFKAS EG +VV LLR+AI RR
Sbjct: 136 DKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGD 195
Query: 653 VELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCIN 712
E++VVA+VNDTV TM+SC YED +CE+G+IVGTG NACYMEE++NV V GD GRMC+N
Sbjct: 196 FEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVN 255
Query: 713 MEWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGV 772
EWGAFGD G L +D VD++S NPG+Q +EK+I G Y+GE+VR +LL L +
Sbjct: 256 TEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENL 315
Query: 773 LFRGQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAV 832
LF G+ ++L+TR F+T+F+S++ESD+ +Q+ IL LGL ++ D +V C++V
Sbjct: 316 LFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESV 375
Query: 833 SQRAAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRC 892
S RAA +C AG+A V+ ++RE+R + + ++VGVDG++YKLHP F A+VR L P C
Sbjct: 376 STRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSC 435
Query: 893 VVTFLQSEDGSGKGAALVTAVACRLA 918
+TF++SE+GSG+GAALV+AVAC+ A
Sbjct: 436 EITFIESEEGSGRGAALVSAVACKKA 461
Score = 375 bits (962), Expect = e-103
Identities = 189/448 (42%), Positives = 284/448 (63%), Gaps = 4/448 (0%)
Query: 32 LVQECLQQFKVTRAQLQQIQASLLGSMEQALRGQASPAPAVRMLPTYVGSTPHGTEQGDF 91
LV++ L +F++ L+++ + M++ LR + +V+MLPTYV STP G+E GDF
Sbjct: 16 LVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDF 75
Query: 92 VVLELGATGASLRVLWVTL-TGIEGH-RVEPRSQEFVIPQEVMLGAGQQLFDFAAHCLSE 149
+ L+LG G + RV+ V + G EG V+ + Q + IP++ M G + LFD+ + C+S+
Sbjct: 76 LSLDLG--GTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISD 133
Query: 150 FLDAQPVNKQGLQLGFSFSFPCHQTGLDRSTLISWTKGFRCSGVEGQDVVQLLRDAIRRQ 209
FLD + + L LGF+FSFP +D+ L++WTKGF+ SG EG +VV LLRDAI+R+
Sbjct: 134 FLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRR 193
Query: 210 GAYNIDVVAVVNDTVGTMMGCEPGVRPCEVGLVVDTGTNACYMEEARHVAVLDEDRGRVC 269
G + +DVVA+VNDTV TM+ C CEVG++V TG NACYMEE ++V +++ D GR+C
Sbjct: 194 GDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMC 253
Query: 270 VSVEWGSFSDDGALGPVLTTFDHTLDHESLNPGAQRFEKMIGGLYLGELVRLVLAHLARC 329
V+ EWG+F D G L L +D +D S NPG Q +EK+IGG Y+GELVRLVL L
Sbjct: 254 VNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDE 313
Query: 330 GVLFGGCTSPALLSQGSILLEHVAEMEDPSTGAARVHAILQDLGLSPGASDVELVQHVCA 389
+LF G S L ++G+ V+++E + +++ IL LGL P +D ++V+ C
Sbjct: 314 NLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACE 373
Query: 390 AVCTRAAQLCAAALAAVLSCLQHSREQQTLQVAVATGGRVCERHPRFCSVLQGTVMLLAP 449
+V TRAA +C+A LA V++ ++ SR + +++ V G V + HP F +V L P
Sbjct: 374 SVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTP 433
Query: 450 ECDVSLIPSVDGGGRGVAMVTAVAARLA 477
C+++ I S +G GRG A+V+AVA + A
Sbjct: 434 SCEITFIESEEGSGRGAALVSAVACKKA 461
>gi|15967161 glucokinase isoform 3 [Homo sapiens]
Length = 464
Score = 473 bits (1216), Expect = e-133
Identities = 235/445 (52%), Positives = 321/445 (72%), Gaps = 9/445 (2%)
Query: 483 LEETLAPFRLNHDQLAAVQAQMRKAMAKGLR---GEASSLRMLPTFVRATPDGSERGDFL 539
+E+ LA F+L + L V +M+K M +GLR E +S++MLPT+VR+TP+GSE GDFL
Sbjct: 15 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 74
Query: 540 ALDLGGTNFRVLLVRVTTG------VQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQ 593
+LDLGGTNFRV+LV+V G V+ ++YSIPE G+ + LFD+I +CI DF
Sbjct: 75 SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 134
Query: 594 KQGLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAV 653
K + + LPLGFTFSFP R +D+GILLNWTKGFKAS EG +VV LLR+AI RR
Sbjct: 135 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 194
Query: 654 ELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINM 713
E++VVA+VNDTV TM+SC YED +CE+G+IVGTG NACYMEE++NV V GD GRMC+N
Sbjct: 195 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 254
Query: 714 EWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVL 773
EWGAFGD G L +D VD++S NPG+Q +EK+I G Y+GE+VR +LL L +L
Sbjct: 255 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 314
Query: 774 FRGQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVS 833
F G+ ++L+TR F+T+F+S++ESD+ +Q+ IL LGL ++ D +V C++VS
Sbjct: 315 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 374
Query: 834 QRAAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCV 893
RAA +C AG+A V+ ++RE+R + + ++VGVDG++YKLHP F A+VR L P C
Sbjct: 375 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 434
Query: 894 VTFLQSEDGSGKGAALVTAVACRLA 918
+TF++SE+GSG+GAALV+AVAC+ A
Sbjct: 435 ITFIESEEGSGRGAALVSAVACKKA 459
Score = 374 bits (961), Expect = e-103
Identities = 191/457 (41%), Positives = 287/457 (62%), Gaps = 7/457 (1%)
Query: 23 LPGPSDSSELVQECLQQFKVTRAQLQQIQASLLGSMEQALRGQASPAPAVRMLPTYVGST 82
LP P+ V++ L +F++ L+++ + M++ LR + +V+MLPTYV ST
Sbjct: 8 LPQPNSQ---VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRST 64
Query: 83 PHGTEQGDFVVLELGATGASLRVLWVTL-TGIEGH-RVEPRSQEFVIPQEVMLGAGQQLF 140
P G+E GDF+ L+LG G + RV+ V + G EG V+ + Q + IP++ M G + LF
Sbjct: 65 PEGSEVGDFLSLDLG--GTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLF 122
Query: 141 DFAAHCLSEFLDAQPVNKQGLQLGFSFSFPCHQTGLDRSTLISWTKGFRCSGVEGQDVVQ 200
D+ + C+S+FLD + + L LGF+FSFP +D+ L++WTKGF+ SG EG +VV
Sbjct: 123 DYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVG 182
Query: 201 LLRDAIRRQGAYNIDVVAVVNDTVGTMMGCEPGVRPCEVGLVVDTGTNACYMEEARHVAV 260
LLRDAI+R+G + +DVVA+VNDTV TM+ C CEVG++V TG NACYMEE ++V +
Sbjct: 183 LLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVEL 242
Query: 261 LDEDRGRVCVSVEWGSFSDDGALGPVLTTFDHTLDHESLNPGAQRFEKMIGGLYLGELVR 320
++ D GR+CV+ EWG+F D G L L +D +D S NPG Q +EK+IGG Y+GELVR
Sbjct: 243 VEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVR 302
Query: 321 LVLAHLARCGVLFGGCTSPALLSQGSILLEHVAEMEDPSTGAARVHAILQDLGLSPGASD 380
LVL L +LF G S L ++G+ V+++E + +++ IL LGL P +D
Sbjct: 303 LVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTD 362
Query: 381 VELVQHVCAAVCTRAAQLCAAALAAVLSCLQHSREQQTLQVAVATGGRVCERHPRFCSVL 440
++V+ C +V TRAA +C+A LA V++ ++ SR + +++ V G V + HP F
Sbjct: 363 CDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERF 422
Query: 441 QGTVMLLAPECDVSLIPSVDGGGRGVAMVTAVAARLA 477
+V L P C+++ I S +G GRG A+V+AVA + A
Sbjct: 423 HASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA 459
>gi|41872631 fatty acid synthase [Homo sapiens]
Length = 2511
Score = 34.3 bits (77), Expect = 0.55
Identities = 56/236 (23%), Positives = 90/236 (38%), Gaps = 35/236 (14%)
Query: 603 PLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVELNVVAIVN 662
P+G F+ + L G+L N T F C+ + +L + +TR EL+ + +
Sbjct: 1964 PVGGVFNLA---VVLRDGLLENQTPEFFQDVCKPKYSGTLNLDRVTREACPELDYFVVFS 2020
Query: 663 DTVGTMMSCGYEDP-RCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEWGAFGDD 721
+SCG + + G C E R G+PG + ++WGA GD
Sbjct: 2021 S-----VSCGRGNAGQSNYGFANSAMERIC---EKRRHEGLPG------LAVQWGAIGDV 2066
Query: 722 GSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLH---LTSLGVLFRGQQ 778
G L + D V QR + + L H++L L +R +
Sbjct: 2067 GILVETMSTNDTIVSGTL----PQRMASCLEVLDLFLNQPHMVLSSFVLAEKAAAYRDRD 2122
Query: 779 IQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQ 834
QR L E + L +R + A+ D L D+LM +EV Q + +
Sbjct: 2123 SQR----------DLVEAVAHILGIRDLAAVNLDSSLADLGLDSLMSVEVRQTLER 2168
>gi|187607437 hypothetical protein LOC27013 [Homo sapiens]
Length = 410
Score = 33.5 bits (75), Expect = 0.94
Identities = 24/72 (33%), Positives = 32/72 (44%), Gaps = 4/72 (5%)
Query: 352 VAEMEDPSTGAARVHAILQDLGLS----PGASDVELVQHVCAAVCTRAAQLCAAALAAVL 407
VA + + A V I Q LGLS PG D+ L C + C +LA V
Sbjct: 237 VAYVSSVALAVASVAVIHQSLGLSCIPTPGPPDLGLTSRCLLEPCIPSVPQCLPSLANVS 296
Query: 408 SCLQHSREQQTL 419
SCL+ S ++L
Sbjct: 297 SCLEGSMGLRSL 308
>gi|73747879 rabconnectin-3 beta isoform 2 [Homo sapiens]
Length = 1457
Score = 32.7 bits (73), Expect = 1.6
Identities = 43/191 (22%), Positives = 71/191 (37%), Gaps = 28/191 (14%)
Query: 340 ALLSQGSILLEHVAEMEDPS--TGAARVHAILQDLGLSPGASDVELVQHVCAAVCTRAAQ 397
A++ G I E AE+E P T I + GL+ G S+ L +H C A+ Q
Sbjct: 1093 AIVLLGVIGAEFGAEIEPPKLLTRPRSSSQIPEGFGLTSGGSNYSLARHTCKALTFLLLQ 1152
Query: 398 LCAAALAAVLSCLQHSREQQTLQVAVATGGRVCERHPRFCSVLQGTVMLLAP-------- 449
+ L HS ++T + G V E + +VL G + L A
Sbjct: 1153 PPSPKLP------PHSTIRRTAIDLIGRGFTVWEPYMDVSAVLMGLLELCADAEKQLANI 1206
Query: 450 ECDVSLIPSVDGG------------GRGVAMVTAVAARLAAHRRLLEETLAPFRLNHDQL 497
+ L P+ D R A +T +A + H L T + ++ L
Sbjct: 1207 TMGLPLSPAADSARSARHALSLIATARPPAFITTIAKEVHRHTALAANTQSQQNMHTTTL 1266
Query: 498 AAVQAQMRKAM 508
A + ++ + +
Sbjct: 1267 ARAKGEILRVI 1277
>gi|73747877 rabconnectin-3 beta isoform 1 [Homo sapiens]
Length = 1490
Score = 32.7 bits (73), Expect = 1.6
Identities = 43/191 (22%), Positives = 71/191 (37%), Gaps = 28/191 (14%)
Query: 340 ALLSQGSILLEHVAEMEDPS--TGAARVHAILQDLGLSPGASDVELVQHVCAAVCTRAAQ 397
A++ G I E AE+E P T I + GL+ G S+ L +H C A+ Q
Sbjct: 1126 AIVLLGVIGAEFGAEIEPPKLLTRPRSSSQIPEGFGLTSGGSNYSLARHTCKALTFLLLQ 1185
Query: 398 LCAAALAAVLSCLQHSREQQTLQVAVATGGRVCERHPRFCSVLQGTVMLLAP-------- 449
+ L HS ++T + G V E + +VL G + L A
Sbjct: 1186 PPSPKLP------PHSTIRRTAIDLIGRGFTVWEPYMDVSAVLMGLLELCADAEKQLANI 1239
Query: 450 ECDVSLIPSVDGG------------GRGVAMVTAVAARLAAHRRLLEETLAPFRLNHDQL 497
+ L P+ D R A +T +A + H L T + ++ L
Sbjct: 1240 TMGLPLSPAADSARSARHALSLIATARPPAFITTIAKEVHRHTALAANTQSQQNMHTTTL 1299
Query: 498 AAVQAQMRKAM 508
A + ++ + +
Sbjct: 1300 ARAKGEILRVI 1310
>gi|50428935 BPY2 interacting protein 1 [Homo sapiens]
Length = 1059
Score = 31.6 bits (70), Expect = 3.6
Identities = 13/28 (46%), Positives = 18/28 (64%)
Query: 331 VLFGGCTSPALLSQGSILLEHVAEMEDP 358
VLF GCT PA L G + L+H+ + +P
Sbjct: 430 VLFPGCTPPACLLDGLVRLQHLRFLREP 457
>gi|155030185 hypothetical protein LOC55726 [Homo sapiens]
Length = 706
Score = 31.2 bits (69), Expect = 4.6
Identities = 26/102 (25%), Positives = 44/102 (43%), Gaps = 10/102 (9%)
Query: 408 SCLQHSREQQTLQVAVATGGRVCER-HPRFCSVLQGTVMLLAPECDVS---------LIP 457
S Q + Q L A+A G R P CS+L G V + C ++ L+
Sbjct: 90 SWTQEDQNLQELMAALAAVGPPNPRADPECCSILHGLVAAVETLCKITEYQHEARTLLME 149
Query: 458 SVDGGGRGVAMVTAVAARLAAHRRLLEETLAPFRLNHDQLAA 499
+ + G ++ A+ +H R+LE+ + H++LAA
Sbjct: 150 NAERVGNRGRIICITNAKSDSHVRMLEDCVQETIHEHNKLAA 191
>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
Length = 347
Score = 30.4 bits (67), Expect = 7.9
Identities = 31/144 (21%), Positives = 59/144 (40%), Gaps = 13/144 (9%)
Query: 372 LGLSPGASDVELVQHVCAAVCTRAAQLCAAALAAVLSCLQHSREQQTLQVAVAT------ 425
LG PG + L ++ VC +LC L+ + E+ ++ T
Sbjct: 33 LGKLPGLKTLVLQNNLIPKVCP---ELCNLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLH 89
Query: 426 --GGRVCERHPRFCSVLQGTVMLLAPECDVSLIPSVDGGGRGVAMVTAVAARLAAHRRLL 483
G R+C P C LQ ++L ++ +P + + ++ +LA+ R L
Sbjct: 90 LSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPREL 149
Query: 484 --EETLAPFRLNHDQLAAVQAQMR 505
E L +LN++QL + +++
Sbjct: 150 CFLENLVELQLNYNQLICIPEEIK 173
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,942,780
Number of Sequences: 37866
Number of extensions: 1500445
Number of successful extensions: 3460
Number of sequences better than 10.0: 18
Number of HSP's better than 10.0 without gapping: 12
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 3379
Number of HSP's gapped (non-prelim): 30
length of query: 923
length of database: 18,247,518
effective HSP length: 112
effective length of query: 811
effective length of database: 14,006,526
effective search space: 11359292586
effective search space used: 11359292586
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.