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Search of human proteins with 192807300
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|192807300 calcium channel, voltage-dependent, L type, alpha
1D subunit isoform b [Homo sapiens]
(2161 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|192807300 calcium channel, voltage-dependent, L type, alpha 1... 4370 0.0
gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D ... 4344 0.0
gi|192807298 calcium channel, voltage-dependent, L type, alpha 1... 4302 0.0
gi|193788536 calcium channel, voltage-dependent, L type, alpha 1... 2756 0.0
gi|193788730 calcium channel, voltage-dependent, L type, alpha 1... 2752 0.0
gi|193788538 calcium channel, voltage-dependent, L type, alpha 1... 2746 0.0
gi|193788540 calcium channel, voltage-dependent, L type, alpha 1... 2746 0.0
gi|193788542 calcium channel, voltage-dependent, L type, alpha 1... 2745 0.0
gi|120433602 calcium channel, voltage-dependent, L type, alpha 1... 2744 0.0
gi|193788544 calcium channel, voltage-dependent, L type, alpha 1... 2744 0.0
gi|193788548 calcium channel, voltage-dependent, L type, alpha 1... 2739 0.0
gi|193794830 calcium channel, voltage-dependent, L type, alpha 1... 2739 0.0
gi|193788526 calcium channel, voltage-dependent, L type, alpha 1... 2736 0.0
gi|193788732 calcium channel, voltage-dependent, L type, alpha 1... 2734 0.0
gi|193794828 calcium channel, voltage-dependent, L type, alpha 1... 2734 0.0
gi|193788530 calcium channel, voltage-dependent, L type, alpha 1... 2734 0.0
gi|193788720 calcium channel, voltage-dependent, L type, alpha 1... 2733 0.0
gi|193788528 calcium channel, voltage-dependent, L type, alpha 1... 2733 0.0
gi|193788728 calcium channel, voltage-dependent, L type, alpha 1... 2731 0.0
gi|193788534 calcium channel, voltage-dependent, L type, alpha 1... 2727 0.0
gi|193788532 calcium channel, voltage-dependent, L type, alpha 1... 2727 0.0
gi|193788724 calcium channel, voltage-dependent, L type, alpha 1... 2726 0.0
gi|193794832 calcium channel, voltage-dependent, L type, alpha 1... 2726 0.0
gi|53832007 calcium channel, voltage-dependent, L type, alpha 1F... 2390 0.0
gi|110349767 calcium channel, voltage-dependent, L type, alpha 1... 2268 0.0
gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo s... 773 0.0
gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo s... 765 0.0
gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B ... 761 0.0
gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E... 727 0.0
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor... 420 e-117
>gi|192807300 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform b [Homo sapiens]
Length = 2161
Score = 4370 bits (11334), Expect = 0.0
Identities = 2161/2161 (100%), Positives = 2161/2161 (100%)
Query: 1 MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA 60
MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA
Sbjct: 1 MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA 60
Query: 61 RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI 120
RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI
Sbjct: 61 RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI 120
Query: 121 SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI 180
SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI
Sbjct: 121 SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI 180
Query: 181 IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR 240
IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR
Sbjct: 181 IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR 240
Query: 241 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT 300
AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT
Sbjct: 241 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT 300
Query: 301 CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360
CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC
Sbjct: 301 CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360
Query: 361 ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG 420
ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG
Sbjct: 361 ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG 420
Query: 421 DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS 480
DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS
Sbjct: 421 DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS 480
Query: 481 GEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTI 540
GEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTI
Sbjct: 481 GEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTI 540
Query: 541 SSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGIT 600
SSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGIT
Sbjct: 541 SSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGIT 600
Query: 601 ETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLF 660
ETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLF
Sbjct: 601 ETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLF 660
Query: 661 IIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGG 720
IIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGG
Sbjct: 661 IIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGG 720
Query: 721 PSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARK 780
PSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARK
Sbjct: 721 PSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARK 780
Query: 781 ESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEVP 840
ESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEVP
Sbjct: 781 ESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEVP 840
Query: 841 AGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSS 900
AGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSS
Sbjct: 841 AGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSS 900
Query: 901 AALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDM 960
AALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDM
Sbjct: 901 AALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDM 960
Query: 961 LVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMI 1020
LVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMI
Sbjct: 961 LVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMI 1020
Query: 1021 VTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNS 1080
VTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNS
Sbjct: 1021 VTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNS 1080
Query: 1081 DFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVA 1140
DFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVA
Sbjct: 1081 DFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVA 1140
Query: 1141 FFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWY 1200
FFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWY
Sbjct: 1141 FFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWY 1200
Query: 1201 VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFK 1260
VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFK
Sbjct: 1201 VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFK 1260
Query: 1261 PKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRL 1320
PKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRL
Sbjct: 1261 PKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRL 1320
Query: 1321 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDN 1380
FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDN
Sbjct: 1321 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDN 1380
Query: 1381 NQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFA 1440
NQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFA
Sbjct: 1381 NQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFA 1440
Query: 1441 IVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRI 1500
IVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRI
Sbjct: 1441 IVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRI 1500
Query: 1501 KHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKI 1560
KHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKI
Sbjct: 1501 KHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKI 1560
Query: 1561 KTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFK 1620
KTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFK
Sbjct: 1561 KTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFK 1620
Query: 1621 KRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEETKREEEDDVFK 1680
KRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEETKREEEDDVFK
Sbjct: 1621 KRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEETKREEEDDVFK 1680
Query: 1681 RNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNH 1740
RNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNH
Sbjct: 1681 RNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNH 1740
Query: 1741 HNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSS 1800
HNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSS
Sbjct: 1741 HNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSS 1800
Query: 1801 VKRTRYYETYIRSDSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSPTW 1860
VKRTRYYETYIRSDSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSPTW
Sbjct: 1801 VKRTRYYETYIRSDSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSPTW 1860
Query: 1861 SRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRR 1920
SRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRR
Sbjct: 1861 SRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRR 1920
Query: 1921 SSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRS 1980
SSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRS
Sbjct: 1921 SSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRS 1980
Query: 1981 WATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEPDISYRTFTPAS 2040
WATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEPDISYRTFTPAS
Sbjct: 1981 WATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEPDISYRTFTPAS 2040
Query: 2041 LTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEME 2100
LTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEME
Sbjct: 2041 LTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEME 2100
Query: 2101 SAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGRDEEDLADEMICITT 2160
SAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGRDEEDLADEMICITT
Sbjct: 2101 SAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGRDEEDLADEMICITT 2160
Query: 2161 L 2161
L
Sbjct: 2161 L 2161
>gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform a [Homo sapiens]
Length = 2181
Score = 4344 bits (11266), Expect = 0.0
Identities = 2154/2181 (98%), Positives = 2158/2181 (98%), Gaps = 20/2181 (0%)
Query: 1 MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA 60
MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA
Sbjct: 1 MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA 60
Query: 61 RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI 120
RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI
Sbjct: 61 RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI 120
Query: 121 SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI 180
SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI
Sbjct: 121 SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI 180
Query: 181 IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR 240
IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR
Sbjct: 181 IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR 240
Query: 241 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT 300
AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT
Sbjct: 241 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT 300
Query: 301 CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360
CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC
Sbjct: 301 CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360
Query: 361 ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG 420
ITMEGWTDVLYW+NDA+G+E PWVYFVSL+I GSFFVLNLVLGVLSGEFSKEREKAKARG
Sbjct: 361 ITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKARG 420
Query: 421 DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS 480
DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS
Sbjct: 421 DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS 480
Query: 481 GEGENRGCCGSLC--------------------QAISKSKLSRRWRRWNRFNRRRCRAAV 520
GEGENRGCCGSL QAISKSKLSRRWRRWNRFNRRRCRAAV
Sbjct: 481 GEGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSRRWRRWNRFNRRRCRAAV 540
Query: 521 KSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ 580
KSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ
Sbjct: 541 KSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ 600
Query: 581 AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLV 640
AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLV
Sbjct: 601 AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLV 660
Query: 641 ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQ 700
ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQ
Sbjct: 661 ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQ 720
Query: 701 ILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES 760
ILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES
Sbjct: 721 ILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES 780
Query: 761 LNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPP 820
LNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPP
Sbjct: 781 LNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPP 840
Query: 821 CDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCH 880
CDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCH
Sbjct: 841 CDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCH 900
Query: 881 KLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTT 940
KLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTT
Sbjct: 901 KLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTT 960
Query: 941 FGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKG 1000
FGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKG
Sbjct: 961 FGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKG 1020
Query: 1001 LKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFI 1060
LKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFI
Sbjct: 1021 LKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFI 1080
Query: 1061 LYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGP 1120
LYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGP
Sbjct: 1081 LYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGP 1140
Query: 1121 IYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYAL 1180
IYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYAL
Sbjct: 1141 IYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYAL 1200
Query: 1181 KARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDIL 1240
KARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDIL
Sbjct: 1201 KARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDIL 1260
Query: 1241 NMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVP 1300
NMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVP
Sbjct: 1261 NMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVP 1320
Query: 1301 TATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML 1360
TATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML
Sbjct: 1321 TATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML 1380
Query: 1361 FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL 1420
FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL
Sbjct: 1381 FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL 1440
Query: 1421 CDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH 1480
CDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH
Sbjct: 1441 CDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH 1500
Query: 1481 HLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS 1540
HLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS
Sbjct: 1501 HLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS 1560
Query: 1541 DGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDE 1600
DGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDE
Sbjct: 1561 DGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDE 1620
Query: 1601 VTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISC 1660
VTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISC
Sbjct: 1621 VTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISC 1680
Query: 1661 DLQDDEPEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPP 1720
DLQDDEPEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPP
Sbjct: 1681 DLQDDEPEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPP 1740
Query: 1721 ASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHV 1780
ASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHV
Sbjct: 1741 ASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHV 1800
Query: 1781 SENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYFRDPHCL 1840
SENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYFRDPHCL
Sbjct: 1801 SENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYFRDPHCL 1860
Query: 1841 GEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCY 1900
GEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCY
Sbjct: 1861 GEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCY 1920
Query: 1901 DSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMA 1960
DSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMA
Sbjct: 1921 DSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMA 1980
Query: 1961 VAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLH 2020
VAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLH
Sbjct: 1981 VAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLH 2040
Query: 2021 RSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKF 2080
RSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKF
Sbjct: 2041 RSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKF 2100
Query: 2081 VSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDE 2140
VSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDE
Sbjct: 2101 VSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDE 2160
Query: 2141 EPDPGRDEEDLADEMICITTL 2161
EPDPGRDEEDLADEMICITTL
Sbjct: 2161 EPDPGRDEEDLADEMICITTL 2181
>gi|192807298 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform c [Homo sapiens]
Length = 2137
Score = 4302 bits (11157), Expect = 0.0
Identities = 2137/2161 (98%), Positives = 2137/2161 (98%), Gaps = 24/2161 (1%)
Query: 1 MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA 60
MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA
Sbjct: 1 MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA 60
Query: 61 RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI 120
RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI
Sbjct: 61 RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI 120
Query: 121 SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI 180
SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI
Sbjct: 121 SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI 180
Query: 181 IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR 240
IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR
Sbjct: 181 IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR 240
Query: 241 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT 300
AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT
Sbjct: 241 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT 300
Query: 301 CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360
CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC
Sbjct: 301 CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360
Query: 361 ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG 420
ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG
Sbjct: 361 ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG 420
Query: 421 DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS 480
DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS
Sbjct: 421 DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS 480
Query: 481 GEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTI 540
GEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTI
Sbjct: 481 GEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTI 540
Query: 541 SSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGIT 600
SSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGIT
Sbjct: 541 SSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGIT 600
Query: 601 ETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLF 660
ETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLF
Sbjct: 601 ETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLF 660
Query: 661 IIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGG 720
IIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGG
Sbjct: 661 IIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGG 720
Query: 721 PSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARK 780
PSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARK
Sbjct: 721 PSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARK 780
Query: 781 ESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEVP 840
ESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEVP
Sbjct: 781 ESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEVP 840
Query: 841 AGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSS 900
AGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSS
Sbjct: 841 AGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSS 900
Query: 901 AALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDM 960
AALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDM
Sbjct: 901 AALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDM 960
Query: 961 LVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMI 1020
LVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMI
Sbjct: 961 LVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMI 1020
Query: 1021 VTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNS 1080
VTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNS
Sbjct: 1021 VTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNS 1080
Query: 1081 DFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVA 1140
DFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVA
Sbjct: 1081 DFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVA 1140
Query: 1141 FFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWY 1200
FFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWY
Sbjct: 1141 FFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWY 1200
Query: 1201 VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFK 1260
VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFK
Sbjct: 1201 VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFK 1260
Query: 1261 PKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRL 1320
PKGYFSDAWNTFDSLIVIGSIIDVALSEAD NSEESNRISITFFRL
Sbjct: 1261 PKGYFSDAWNTFDSLIVIGSIIDVALSEAD---------------NSEESNRISITFFRL 1305
Query: 1321 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDN 1380
FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDN
Sbjct: 1306 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDN 1365
Query: 1381 NQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFA 1440
NQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFA
Sbjct: 1366 NQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFA 1425
Query: 1441 IVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRI 1500
IVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRI
Sbjct: 1426 IVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRI 1485
Query: 1501 KHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKI 1560
KHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKI
Sbjct: 1486 KHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKI 1545
Query: 1561 KTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFK 1620
KTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFK
Sbjct: 1546 KTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFK 1605
Query: 1621 KRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEETKREEEDDVFK 1680
KRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEETKREEEDDVFK
Sbjct: 1606 KRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEETKREEEDDVFK 1665
Query: 1681 RNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNH 1740
RNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNH
Sbjct: 1666 RNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNH 1725
Query: 1741 HNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSS 1800
HNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSS
Sbjct: 1726 HNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSS 1785
Query: 1801 VKRTRYYETYIRSDSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSPTW 1860
VK RSDSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSPTW
Sbjct: 1786 VK---------RSDSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSPTW 1836
Query: 1861 SRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRR 1920
SRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRR
Sbjct: 1837 SRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRR 1896
Query: 1921 SSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRS 1980
SSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRS
Sbjct: 1897 SSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRS 1956
Query: 1981 WATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEPDISYRTFTPAS 2040
WATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEPDISYRTFTPAS
Sbjct: 1957 WATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEPDISYRTFTPAS 2016
Query: 2041 LTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEME 2100
LTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEME
Sbjct: 2017 LTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEME 2076
Query: 2101 SAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGRDEEDLADEMICITT 2160
SAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGRDEEDLADEMICITT
Sbjct: 2077 SAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGRDEEDLADEMICITT 2136
Query: 2161 L 2161
L
Sbjct: 2137 L 2137
>gi|193788536 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 14 [Homo sapiens]
Length = 2138
Score = 2756 bits (7144), Expect = 0.0
Identities = 1460/2157 (67%), Positives = 1668/2157 (77%), Gaps = 114/2157 (5%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYWM DAMG+ELPWVYFVSLVIFGSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN ILG DY
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF DAWNTFD+LIV+GSI+D+A
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1286 LSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1345
++E +P E + N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK
Sbjct: 1300 ITEVNPAEH----TQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1355
Query: 1346 SFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATG 1405
SFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATG
Sbjct: 1356 SFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATG 1415
Query: 1406 EAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVI 1463
EAWQ+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVI
Sbjct: 1416 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1475
Query: 1464 MDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1523
MDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP
Sbjct: 1476 MDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1535
Query: 1524 HRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKK 1583
HRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTEGNLEQANEELRA+IKKIWK+
Sbjct: 1536 HRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKR 1595
Query: 1584 TSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAG 1643
TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAG
Sbjct: 1596 TSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAG 1654
Query: 1644 LRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDDVFKRNGALLGNHVNHVNSDR 1697
LRTLHDIGPEIRRAIS DL +E E EDD+F+R G L GNHV++ SD
Sbjct: 1655 LRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDG 1714
Query: 1698 RDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNAN 1757
R + QT TT RPLH+ + DTE P +S +++S T +NAN
Sbjct: 1715 RSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNAN 1766
Query: 1758 LNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGD 1817
+NNAN + RP+ + S H P R V+ + + R S +
Sbjct: 1767 INNANNTALGRLPRPA----GYPSTVSTVEGHGPPLSPAIR--VQEVAWKLSSNRCHSRE 1820
Query: 1818 EQLPTICREDPEIHGYF-----RDPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRY 1871
Q +E+ + D E S+E Y+DD
Sbjct: 1821 SQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDD---------------- 1864
Query: 1872 PGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQ 1931
+ Q L ++D D R+SP+R L + + RR+SF+ ECL+RQ
Sbjct: 1865 -------------ENRQLTLPEEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQ 1907
Query: 1932 SSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYR 1991
+ +T LPLHL+ Q +AVAGL + +SP+ R +ATPPATP R
Sbjct: 1908 KDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSR 1962
Query: 1992 DWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSF 2047
W P P +++E E+ +++N S PS+H SW P + R P SL VPS
Sbjct: 1963 GWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQA 2022
Query: 2048 RNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLL 2107
SA SLVEAVLISEGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L
Sbjct: 2023 GAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNIL 2082
Query: 2108 NGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2161
+G NG + P + +D QD G D R EE+L D + +++L
Sbjct: 2083 SGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2138
>gi|193788730 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 4 [Homo sapiens]
Length = 2173
Score = 2752 bits (7133), Expect = 0.0
Identities = 1460/2165 (67%), Positives = 1678/2165 (77%), Gaps = 95/2165 (4%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN ILG DY
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF DAWNTFD+LIV+GSI+D+A
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1286 LSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1345
++E +P E + N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK
Sbjct: 1300 ITEVNPAEH----TQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1355
Query: 1346 SFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATG 1405
SFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATG
Sbjct: 1356 SFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATG 1415
Query: 1406 EAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVI 1463
EAWQ+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVI
Sbjct: 1416 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1475
Query: 1464 MDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1523
MDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP
Sbjct: 1476 MDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1535
Query: 1524 HRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKK 1583
HRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTEGNLEQANEELRA+IKKIWK+
Sbjct: 1536 HRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKR 1595
Query: 1584 TSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAG 1643
TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAG
Sbjct: 1596 TSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAG 1654
Query: 1644 LRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDDVFKRNGALLGNHVNHVNSDR 1697
LRTLHDIGPEIRRAIS DL +E E EDD+F+R G L GNHV++ SD
Sbjct: 1655 LRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDG 1714
Query: 1698 RDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNAN 1757
R + QT TT RPLH+ + DTE P +S +++S T +NAN
Sbjct: 1715 RSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNAN 1766
Query: 1758 LNNANMSKAAHGKRPSIGNLEHVSENGHH----SSHKHDREPQRRSSVKRTRYY----ET 1809
+NNAN + RP+ G VS H S +E + S R R+ +
Sbjct: 1767 INNANNTALGRLPRPA-GYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRERHVPMCEDL 1825
Query: 1810 YIRSDSGDEQLPTIC----REDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSPTWSRQNY 1865
+R DSG C + +P + QE S +E YE + N+
Sbjct: 1826 ELRRDSGSAGTQAHCLLLRKANPSRCHSRESQAAMAGQEETSQDETYE-------VKMNH 1878
Query: 1866 GYYSRYPGRNIDSE--RPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSF 1923
+ + +E + + Q L ++D D R+SP+R L + + RR+SF
Sbjct: 1879 DTEACSEPSLLSTEMLSYQDDENRQLTLPEEDK---RDIRQSPKRGFL-RSASLGRRASF 1934
Query: 1924 NFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWAT 1983
+ ECL+RQ + +T LPLHL+ Q +AVAGL + +SP+ R +AT
Sbjct: 1935 HLECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFAT 1989
Query: 1984 PPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPA 2039
PPATP R W P P +++E E+ +++N S PS+H SW P + R P
Sbjct: 1990 PPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPV 2049
Query: 2040 SLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEM 2099
SL VPS SA SLVEAVLISEGLG++A+DPKF+ T E+ADACD+TI+EM
Sbjct: 2050 SLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEM 2109
Query: 2100 ESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMI 2156
ESAA +L+G NG + P + +D QD G D R EE+L D +
Sbjct: 2110 ESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEELQDSRV 2168
Query: 2157 CITTL 2161
+++L
Sbjct: 2169 YVSSL 2173
>gi|193788538 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 15 [Homo sapiens]
Length = 2138
Score = 2746 bits (7119), Expect = 0.0
Identities = 1457/2157 (67%), Positives = 1664/2157 (77%), Gaps = 114/2157 (5%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN ILG DY
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPKGYFSD WN FD LIVIGSIIDV
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVI 1299
Query: 1286 LSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1345
LSE +P E + N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK
Sbjct: 1300 LSETNPAEH----TQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1355
Query: 1346 SFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATG 1405
SFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATG
Sbjct: 1356 SFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATG 1415
Query: 1406 EAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVI 1463
EAWQ+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVI
Sbjct: 1416 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1475
Query: 1464 MDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1523
MDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP
Sbjct: 1476 MDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1535
Query: 1524 HRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKK 1583
HRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTEGNLEQANEELRA+IKKIWK+
Sbjct: 1536 HRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKR 1595
Query: 1584 TSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAG 1643
TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAG
Sbjct: 1596 TSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAG 1654
Query: 1644 LRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDDVFKRNGALLGNHVNHVNSDR 1697
LRTLHDIGPEIRRAIS DL +E E EDD+F+R G L GNHV++ SD
Sbjct: 1655 LRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDG 1714
Query: 1698 RDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNAN 1757
R + QT TT RPLH+ + DTE P +S +++S T +NAN
Sbjct: 1715 RSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNAN 1766
Query: 1758 LNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGD 1817
+NNAN + RP+ + S H P R V+ + + R S +
Sbjct: 1767 INNANNTALGRLPRPA----GYPSTVSTVEGHGPPLSPAIR--VQEVAWKLSSNRCHSRE 1820
Query: 1818 EQLPTICREDPEIHGYF-----RDPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRY 1871
Q +E+ + D E S+E Y+DD
Sbjct: 1821 SQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDD---------------- 1864
Query: 1872 PGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQ 1931
+ Q L ++D D R+SP+R L + + RR+SF+ ECL+RQ
Sbjct: 1865 -------------ENRQLTLPEEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQ 1907
Query: 1932 SSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYR 1991
+ +T LPLHL+ Q +AVAGL + +SP+ R +ATPPATP R
Sbjct: 1908 KDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSR 1962
Query: 1992 DWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSF 2047
W P P +++E E+ +++N S PS+H SW P + R P SL VPS
Sbjct: 1963 GWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQA 2022
Query: 2048 RNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLL 2107
SA SLVEAVLISEGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L
Sbjct: 2023 GAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNIL 2082
Query: 2108 NGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2161
+G NG + P + +D QD G D R EE+L D + +++L
Sbjct: 2083 SGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2138
>gi|193788540 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 16 [Homo sapiens]
Length = 2138
Score = 2746 bits (7117), Expect = 0.0
Identities = 1457/2157 (67%), Positives = 1662/2157 (77%), Gaps = 114/2157 (5%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN IL YFD
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPKGYFSD WN FD LIVIGSIIDV
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVI 1299
Query: 1286 LSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1345
LSE +P E + N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK
Sbjct: 1300 LSETNPAEH----TQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1355
Query: 1346 SFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATG 1405
SFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATG
Sbjct: 1356 SFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATG 1415
Query: 1406 EAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVI 1463
EAWQ+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVI
Sbjct: 1416 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1475
Query: 1464 MDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1523
MDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP
Sbjct: 1476 MDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1535
Query: 1524 HRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKK 1583
HRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTEGNLEQANEELRA+IKKIWK+
Sbjct: 1536 HRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKR 1595
Query: 1584 TSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAG 1643
TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAG
Sbjct: 1596 TSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAG 1654
Query: 1644 LRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDDVFKRNGALLGNHVNHVNSDR 1697
LRTLHDIGPEIRRAIS DL +E E EDD+F+R G L GNHV++ SD
Sbjct: 1655 LRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDG 1714
Query: 1698 RDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNAN 1757
R + QT TT RPLH+ + DTE P +S +++S T +NAN
Sbjct: 1715 RSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNAN 1766
Query: 1758 LNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGD 1817
+NNAN + RP+ + S H P R V+ + + R S +
Sbjct: 1767 INNANNTALGRLPRPA----GYPSTVSTVEGHGPPLSPAIR--VQEVAWKLSSNRCHSRE 1820
Query: 1818 EQLPTICREDPEIHGYF-----RDPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRY 1871
Q +E+ + D E S+E Y+DD
Sbjct: 1821 SQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDD---------------- 1864
Query: 1872 PGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQ 1931
+ Q L ++D D R+SP+R L + + RR+SF+ ECL+RQ
Sbjct: 1865 -------------ENRQLTLPEEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQ 1907
Query: 1932 SSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYR 1991
+ +T LPLHL+ Q +AVAGL + +SP+ R +ATPPATP R
Sbjct: 1908 KDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSR 1962
Query: 1992 DWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSF 2047
W P P +++E E+ +++N S PS+H SW P + R P SL VPS
Sbjct: 1963 GWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQA 2022
Query: 2048 RNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLL 2107
SA SLVEAVLISEGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L
Sbjct: 2023 GAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNIL 2082
Query: 2108 NGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2161
+G NG + P + +D QD G D R EE+L D + +++L
Sbjct: 2083 SGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2138
>gi|193788542 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 17 [Homo sapiens]
Length = 2138
Score = 2745 bits (7116), Expect = 0.0
Identities = 1453/2157 (67%), Positives = 1666/2157 (77%), Gaps = 114/2157 (5%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN ILG DY
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF DAWNTFD+LIV+GSI+D+A
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1286 LSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1345
++E +P E + N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK
Sbjct: 1300 ITEVNPAEH----TQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1355
Query: 1346 SFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATG 1405
SFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATG
Sbjct: 1356 SFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATG 1415
Query: 1406 EAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVI 1463
EAWQ+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVI
Sbjct: 1416 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1475
Query: 1464 MDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1523
MDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP
Sbjct: 1476 MDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1535
Query: 1524 HRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKK 1583
HRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTEGNLEQANEELRA+IKKIWK+
Sbjct: 1536 HRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKR 1595
Query: 1584 TSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAG 1643
TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAG
Sbjct: 1596 TSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAG 1654
Query: 1644 LRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDDVFKRNGALLGNHVNHVNSDR 1697
LRTLHDIGPEIRRAIS DL +E E EDD+F+R G L GNHV++ SD
Sbjct: 1655 LRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDG 1714
Query: 1698 RDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNAN 1757
R + QT TT RPLH+ + DTE P +S +++S T +NAN
Sbjct: 1715 RSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNAN 1766
Query: 1758 LNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGD 1817
+NNAN + RP+ + S H P R V+ + + R S +
Sbjct: 1767 INNANNTALGRLPRPA----GYPSTVSTVEGHGPPLSPAIR--VQEVAWKLSSNRCHSRE 1820
Query: 1818 EQLPTICREDPEIHGYF-----RDPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRY 1871
Q +E+ + D E S+E Y+DD
Sbjct: 1821 SQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDD---------------- 1864
Query: 1872 PGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQ 1931
+ Q L ++D D R+SP+R L + + RR+SF+ ECL+RQ
Sbjct: 1865 -------------ENRQLTLPEEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQ 1907
Query: 1932 SSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYR 1991
+ +T LPLHL+ Q +AVAGL + +SP+ R +ATPPATP R
Sbjct: 1908 KDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSR 1962
Query: 1992 DWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSF 2047
W P P +++E E+ +++N S PS+H SW P + R P SL VPS
Sbjct: 1963 GWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQA 2022
Query: 2048 RNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLL 2107
SA SLVEAVLISEGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L
Sbjct: 2023 GAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNIL 2082
Query: 2108 NGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2161
+G NG + P + +D QD G D R EE+L D + +++L
Sbjct: 2083 SGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2138
>gi|120433602 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 18 [Homo sapiens]
Length = 2138
Score = 2744 bits (7114), Expect = 0.0
Identities = 1453/2157 (67%), Positives = 1664/2157 (77%), Gaps = 114/2157 (5%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN IL YFD
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF DAWNTFD+LIV+GSI+D+A
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1286 LSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1345
++E +P E + N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK
Sbjct: 1300 ITEVNPAEH----TQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1355
Query: 1346 SFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATG 1405
SFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATG
Sbjct: 1356 SFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATG 1415
Query: 1406 EAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVI 1463
EAWQ+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVI
Sbjct: 1416 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1475
Query: 1464 MDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1523
MDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP
Sbjct: 1476 MDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1535
Query: 1524 HRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKK 1583
HRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTEGNLEQANEELRA+IKKIWK+
Sbjct: 1536 HRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKR 1595
Query: 1584 TSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAG 1643
TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAG
Sbjct: 1596 TSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAG 1654
Query: 1644 LRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDDVFKRNGALLGNHVNHVNSDR 1697
LRTLHDIGPEIRRAIS DL +E E EDD+F+R G L GNHV++ SD
Sbjct: 1655 LRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDG 1714
Query: 1698 RDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNAN 1757
R + QT TT RPLH+ + DTE P +S +++S T +NAN
Sbjct: 1715 RSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNAN 1766
Query: 1758 LNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGD 1817
+NNAN + RP+ + S H P R V+ + + R S +
Sbjct: 1767 INNANNTALGRLPRPA----GYPSTVSTVEGHGPPLSPAIR--VQEVAWKLSSNRCHSRE 1820
Query: 1818 EQLPTICREDPEIHGYF-----RDPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRY 1871
Q +E+ + D E S+E Y+DD
Sbjct: 1821 SQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDD---------------- 1864
Query: 1872 PGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQ 1931
+ Q L ++D D R+SP+R L + + RR+SF+ ECL+RQ
Sbjct: 1865 -------------ENRQLTLPEEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQ 1907
Query: 1932 SSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYR 1991
+ +T LPLHL+ Q +AVAGL + +SP+ R +ATPPATP R
Sbjct: 1908 KDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSR 1962
Query: 1992 DWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSF 2047
W P P +++E E+ +++N S PS+H SW P + R P SL VPS
Sbjct: 1963 GWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQA 2022
Query: 2048 RNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLL 2107
SA SLVEAVLISEGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L
Sbjct: 2023 GAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNIL 2082
Query: 2108 NGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2161
+G NG + P + +D QD G D R EE+L D + +++L
Sbjct: 2083 SGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2138
>gi|193788544 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 19 [Homo sapiens]
Length = 2135
Score = 2744 bits (7114), Expect = 0.0
Identities = 1457/2155 (67%), Positives = 1660/2155 (77%), Gaps = 113/2155 (5%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFADSDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNFDN 349
ELF+GKMHKTC+ + I AE+DP+PCA +G+GRQC NGT C+ GW GP GITNFDN
Sbjct: 288 ELFMGKMHKTCYNQEG-IAAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDN 345
Query: 350 FAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 409
FAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSGEF
Sbjct: 346 FAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 405
Query: 410 SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSMPT 468
SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SMPT
Sbjct: 406 SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPT 465
Query: 469 SETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTF 525
SETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS F
Sbjct: 466 SETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVF 523
Query: 526 YWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVS 585
YWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYFVS
Sbjct: 524 YWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVS 583
Query: 586 LFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLN 645
LFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASLLN
Sbjct: 584 LFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLN 643
Query: 646 SMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGE 705
S++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILTGE
Sbjct: 644 SVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGE 703
Query: 706 DWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQ 765
DWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +AQ
Sbjct: 704 DWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQ 763
Query: 766 KEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTIDDY 808
KEE EEKERKK+AR S E K+ KP V + K+ +DD
Sbjct: 764 KEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMDDL 823
Query: 809 R-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFF 867
+ E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SAFF
Sbjct: 824 QPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFF 878
Query: 868 ILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFT 927
I S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN IL YFD FT
Sbjct: 879 IFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFT 938
Query: 928 AIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLR 987
IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRVLR
Sbjct: 939 TIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLR 998
Query: 988 VLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDE 1047
VLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+D
Sbjct: 999 VLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDS 1058
Query: 1048 AKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALL 1107
+K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP LL
Sbjct: 1059 SKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELL 1118
Query: 1108 YKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCE 1167
Y++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKNCE
Sbjct: 1119 YRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCE 1178
Query: 1168 LDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHY 1227
LDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQHY
Sbjct: 1179 LDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHY 1238
Query: 1228 EQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALS 1287
QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPKGYFSD WN FD LIVIGSIIDV LS
Sbjct: 1239 GQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILS 1298
Query: 1288 EADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSF 1347
E +P E + N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSF
Sbjct: 1299 ETNPAEH----TQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSF 1354
Query: 1348 QALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEA 1407
QALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATGEA
Sbjct: 1355 QALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEA 1414
Query: 1408 WQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMD 1465
WQ+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVIMD
Sbjct: 1415 WQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMD 1474
Query: 1466 NFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHR 1525
NFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHR
Sbjct: 1475 NFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHR 1534
Query: 1526 VACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTS 1585
VACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTEGNLEQANEELRA+IKKIWK+TS
Sbjct: 1535 VACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTS 1594
Query: 1586 MKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLR 1645
MKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAGLR
Sbjct: 1595 MKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAGLR 1653
Query: 1646 TLHDIGPEIRRAISCDLQDDE------PEETKREEEDDVFKRNGALLGNHVNHVNSDRRD 1699
TLHDIGPEIRRAIS DL +E E EDD+F+R G L GNHV++ SD R
Sbjct: 1654 TLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRS 1713
Query: 1700 SLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLN 1759
+ QT TT RPLH+ + DTE P +S +++S T +NAN+N
Sbjct: 1714 AFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNANIN 1765
Query: 1760 NANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQ 1819
NAN + RP+ + S H P R V+ + + R S + Q
Sbjct: 1766 NANNTALGRLPRPA----GYPSTVSTVEGHGPPLSPAIR--VQEVAWKLSSNRCHSRESQ 1819
Query: 1820 LPTICREDPEIHGYF-----RDPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRYPG 1873
+E+ + D E S+E Y+DD
Sbjct: 1820 AAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDD------------------ 1861
Query: 1874 RNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSS 1933
+ Q L ++D D R+SP+R L + + RR+SF+ ECL+RQ
Sbjct: 1862 -----------ENRQLTLPEEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQKD 1906
Query: 1934 QEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDW 1993
+ +T LPLHL+ Q +AVAGL + +SP+ R +ATPPATP R W
Sbjct: 1907 R-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGW 1961
Query: 1994 TPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSFRN 2049
P P +++E E+ +++N S PS+H SW P + R P SL VPS
Sbjct: 1962 PPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGA 2021
Query: 2050 KNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNG 2109
SA SLVEAVLISEGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L+G
Sbjct: 2022 PGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSG 2081
Query: 2110 NVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2161
NG + P + +D QD G D R EE+L D + +++L
Sbjct: 2082 GAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2135
>gi|193788548 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 20 [Homo sapiens]
Length = 2127
Score = 2739 bits (7100), Expect = 0.0
Identities = 1451/2157 (67%), Positives = 1663/2157 (77%), Gaps = 125/2157 (5%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN ILG DY
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF DAWNTFD+LIV+GSI+D+A
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1286 LSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1345
++E + N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK
Sbjct: 1300 ITEVN---------------NAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1344
Query: 1346 SFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATG 1405
SFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATG
Sbjct: 1345 SFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATG 1404
Query: 1406 EAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVI 1463
EAWQ+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVI
Sbjct: 1405 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1464
Query: 1464 MDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1523
MDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP
Sbjct: 1465 MDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1524
Query: 1524 HRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKK 1583
HRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTEGNLEQANEELRA+IKKIWK+
Sbjct: 1525 HRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKR 1584
Query: 1584 TSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAG 1643
TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAG
Sbjct: 1585 TSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAG 1643
Query: 1644 LRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDDVFKRNGALLGNHVNHVNSDR 1697
LRTLHDIGPEIRRAIS DL +E E EDD+F+R G L GNHV++ SD
Sbjct: 1644 LRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDG 1703
Query: 1698 RDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNAN 1757
R + QT TT RPLH+ + DTE P +S +++S T +NAN
Sbjct: 1704 RSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNAN 1755
Query: 1758 LNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGD 1817
+NNAN + RP+ + S H P R V+ + + R S +
Sbjct: 1756 INNANNTALGRLPRPA----GYPSTVSTVEGHGPPLSPAIR--VQEVAWKLSSNRCHSRE 1809
Query: 1818 EQLPTICREDPEIHGYF-----RDPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRY 1871
Q +E+ + D E S+E Y+DD
Sbjct: 1810 SQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDD---------------- 1853
Query: 1872 PGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQ 1931
+ Q L ++D D R+SP+R L + + RR+SF+ ECL+RQ
Sbjct: 1854 -------------ENRQLTLPEEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQ 1896
Query: 1932 SSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYR 1991
+ +T LPLHL+ Q +AVAGL + +SP+ R +ATPPATP R
Sbjct: 1897 KDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSR 1951
Query: 1992 DWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSF 2047
W P P +++E E+ +++N S PS+H SW P + R P SL VPS
Sbjct: 1952 GWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQA 2011
Query: 2048 RNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLL 2107
SA SLVEAVLISEGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L
Sbjct: 2012 GAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNIL 2071
Query: 2108 NGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2161
+G NG + P + +D QD G D R EE+L D + +++L
Sbjct: 2072 SGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2127
>gi|193794830 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 10 [Homo sapiens]
Length = 2155
Score = 2739 bits (7099), Expect = 0.0
Identities = 1456/2170 (67%), Positives = 1663/2170 (76%), Gaps = 123/2170 (5%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN ILG DY
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPKGYFSD WN FD LIVIGSIIDV
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVI 1299
Query: 1286 LSEADP-------------TESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSR 1332
LSE + V + N+EE++RISITFFRLFRVMRLVKLLSR
Sbjct: 1300 LSETNHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSR 1359
Query: 1333 GEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTF 1392
GEGIRTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTF
Sbjct: 1360 GEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTF 1419
Query: 1393 PQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYML 1450
PQAVLLLFRCATGEAWQ+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYML
Sbjct: 1420 PQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYML 1479
Query: 1451 CAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLR 1510
CAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLR
Sbjct: 1480 CAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLR 1539
Query: 1511 RIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQAN 1570
RIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTEGNLEQAN
Sbjct: 1540 RIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQAN 1599
Query: 1571 EELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGK 1630
EELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK
Sbjct: 1600 EELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK 1659
Query: 1631 YPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDDVFKRNGA 1684
P++ ++LQAGLRTLHDIGPEIRRAIS DL +E E EDD+F+R G
Sbjct: 1660 -PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGG 1718
Query: 1685 LLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHN 1744
L GNHV++ SD R + QT TT RPLH+ + DTE P +S +++
Sbjct: 1719 LFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPSSYS 1776
Query: 1745 SIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSSVKRT 1804
S T +NAN+NNAN + RP+ + S H P R V+
Sbjct: 1777 S------TGSNANINNANNTALGRLPRPA----GYPSTVSTVEGHGPPLSPAIR--VQEV 1824
Query: 1805 RYYETYIRSDSGDEQLPTICREDPEIHGYF-----RDPHCLGEQEYFSSEE-CYEDDSSP 1858
+ + R S + Q +E+ + D E S+E Y+DD
Sbjct: 1825 AWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDD--- 1881
Query: 1859 TWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASH 1918
+ Q L ++D D R+SP+R L + +
Sbjct: 1882 --------------------------ENRQLTLPEEDK---RDIRQSPKRGFL-RSASLG 1911
Query: 1919 RRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHST 1978
RR+SF+ ECL+RQ + +T LPLHL+ Q +AVAGL + +SP+
Sbjct: 1912 RRASFHLECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFP 1966
Query: 1979 RSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DISYR 2034
R +ATPPATP R W P P +++E E+ +++N S PS+H SW P + R
Sbjct: 1967 RPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAAR 2026
Query: 2035 TFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDL 2094
P SL VPS SA SLVEAVLISEGLG++A+DPKF+ T E+ADACD+
Sbjct: 2027 RVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDM 2086
Query: 2095 TIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDL 2151
TI+EMESAA +L+G NG + P + +D QD G D R EE+L
Sbjct: 2087 TIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEEL 2145
Query: 2152 ADEMICITTL 2161
D + +++L
Sbjct: 2146 QDSRVYVSSL 2155
>gi|193788526 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 6 [Homo sapiens]
Length = 2158
Score = 2736 bits (7093), Expect = 0.0
Identities = 1454/2177 (66%), Positives = 1667/2177 (76%), Gaps = 134/2177 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFD-- 923
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN IL YFD
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 924 ------------------YAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGV 965
Y FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV V
Sbjct: 940 FTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSV 999
Query: 966 SLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLL 1025
SL+SFGIQSSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLL
Sbjct: 1000 SLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLL 1059
Query: 1026 QFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFD 1085
QFMFACIGVQLFKGK Y C+D +K EC+G +I YKDG+VD P+++ R W+NS F+FD
Sbjct: 1060 QFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFD 1119
Query: 1086 NVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMN 1145
NVL+AMMALFTVSTFEGWP LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMN
Sbjct: 1120 NVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMN 1179
Query: 1146 IFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSS 1205
IFVGFVIVTFQEQGE+EYKNCELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+
Sbjct: 1180 IFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNST 1239
Query: 1206 PFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYF 1265
FEY+MFVLI+LNT+CLAMQHY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF
Sbjct: 1240 YFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYF 1299
Query: 1266 SDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMR 1325
DAWNTFD+LIV+GSI+D+A++E +P E + N+EE++RISITFFRLFRVMR
Sbjct: 1300 CDAWNTFDALIVVGSIVDIAITEVNPAEH----TQCSPSMNAEENSRISITFFRLFRVMR 1355
Query: 1326 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINR 1385
LVKLLSRGEGIRTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INR
Sbjct: 1356 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINR 1415
Query: 1386 NNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVY 1443
NNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK C PES+ + E CGS+FA+ Y
Sbjct: 1416 NNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFY 1475
Query: 1444 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHL 1503
FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHL
Sbjct: 1476 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHL 1535
Query: 1504 DVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE 1563
DVVTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTE
Sbjct: 1536 DVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTE 1595
Query: 1564 GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRK 1623
GNLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRK
Sbjct: 1596 GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRK 1655
Query: 1624 EQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDD 1677
EQGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL +E E EDD
Sbjct: 1656 EQGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDD 1714
Query: 1678 VFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVC 1737
+F+R G L GNHV++ SD R + QT TT RPLH+ + DTE P +S
Sbjct: 1715 IFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST- 1772
Query: 1738 HNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQR 1797
+++S T +NAN+NNAN + RP+ + S H P
Sbjct: 1773 FTPSSYSS------TGSNANINNANNTALGRLPRPA----GYPSTVSTVEGHGPPLSPAI 1822
Query: 1798 RSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYF-----RDPHCLGEQEYFSSEE-C 1851
R V+ + + R S + Q +E+ + D E S+E
Sbjct: 1823 R--VQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLS 1880
Query: 1852 YEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLL 1911
Y+DD + Q L ++D D R+SP+R L
Sbjct: 1881 YQDD-----------------------------ENRQLTLPEEDK---RDIRQSPKRGFL 1908
Query: 1912 PPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQK 1971
+ + RR+SF+ ECL+RQ + +T LPLHL+ Q +AVAGL +
Sbjct: 1909 -RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRS 1962
Query: 1972 YSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP-- 2029
+SP+ R +ATPPATP R W P P +++E E+ +++N S PS+H SW P
Sbjct: 1963 HSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGG 2022
Query: 2030 --DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHE 2087
+ R P SL VPS SA SLVEAVLISEGLG++A+DPKF+ T E
Sbjct: 2023 GGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQE 2082
Query: 2088 IADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR- 2146
+ADACD+TI+EMESAA +L+G NG + P + +D QD G D R
Sbjct: 2083 LADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARG 2141
Query: 2147 --DEEDLADEMICITTL 2161
EE+L D + +++L
Sbjct: 2142 RPSEEELQDSRVYVSSL 2158
>gi|193788732 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 5 [Homo sapiens]
Length = 2166
Score = 2734 bits (7088), Expect = 0.0
Identities = 1455/2185 (66%), Positives = 1666/2185 (76%), Gaps = 142/2185 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN IL YFD
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFS------------------- 1266
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPKGYFS
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVI 1299
Query: 1267 ---------DAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITF 1317
DAWNTFD+LIV+GSI+D+A++E +P E + N+EE++RISITF
Sbjct: 1300 LSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEH----TQCSPSMNAEENSRISITF 1355
Query: 1318 FRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAM 1377
FRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+FGK+A+
Sbjct: 1356 FRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL 1415
Query: 1378 RDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE--EYTC 1435
D +INRNNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK C PES+ + E C
Sbjct: 1416 NDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPC 1475
Query: 1436 GSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPE 1495
GS+FA+ YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDPE
Sbjct: 1476 GSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPE 1535
Query: 1496 AKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVR 1555
AKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTVMFNATLFALVR
Sbjct: 1536 AKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVR 1595
Query: 1556 TALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDY 1615
TAL+IKTEGNLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+Y
Sbjct: 1596 TALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEY 1655
Query: 1616 FRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDE------PEE 1669
FRKFKKRKEQGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL +E E
Sbjct: 1656 FRKFKKRKEQGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEA 1714
Query: 1670 TKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLF 1729
EDD+F+R G L GNHV++ SD R + QT TT RPLH+ + DTE P
Sbjct: 1715 VSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSH 1773
Query: 1730 PPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSH 1789
+S +++S T +NAN+NNAN + RP+ + S H
Sbjct: 1774 EKLVDST-FTPSSYSS------TGSNANINNANNTALGRLPRPA----GYPSTVSTVEGH 1822
Query: 1790 KHDREPQRRSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYF-----RDPHCLGEQE 1844
P R V+ + + R S + Q +E+ + D E
Sbjct: 1823 GPPLSPAIR--VQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPS 1880
Query: 1845 YFSSEE-CYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSR 1903
S+E Y+DD + Q L ++D D R
Sbjct: 1881 LLSTEMLSYQDD-----------------------------ENRQLTLPEEDK---RDIR 1908
Query: 1904 RSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAG 1963
+SP+R L + + RR+SF+ ECL+RQ + +T LPLHL+ Q +AVAG
Sbjct: 1909 QSPKRGFL-RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAG 1962
Query: 1964 LDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSS 2023
L + +SP+ R +ATPPATP R W P P +++E E+ +++N S PS+H S
Sbjct: 1963 LSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGS 2022
Query: 2024 WYTDEP----DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPK 2079
W P + R P SL VPS SA SLVEAVLISEGLG++A+DPK
Sbjct: 2023 WAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPK 2082
Query: 2080 FVSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSD 2139
F+ T E+ADACD+TI+EMESAA +L+G NG + P + +D QD G D
Sbjct: 2083 FIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEED 2141
Query: 2140 EEPDPGR---DEEDLADEMICITTL 2161
R EE+L D + +++L
Sbjct: 2142 AGCVRARGRPSEEELQDSRVYVSSL 2166
>gi|193794828 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 7 [Homo sapiens]
Length = 2157
Score = 2734 bits (7087), Expect = 0.0
Identities = 1457/2176 (66%), Positives = 1662/2176 (76%), Gaps = 133/2176 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN IL YFD
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPKGYFSD WN FD LIVIGSIIDV
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVI 1299
Query: 1286 LSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1345
LSE +P E + N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK
Sbjct: 1300 LSETNPAEH----TQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1355
Query: 1346 SFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATG 1405
SFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATG
Sbjct: 1356 SFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATG 1415
Query: 1406 EAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVI 1463
EAWQ+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVI
Sbjct: 1416 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1475
Query: 1464 MDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1523
MDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP
Sbjct: 1476 MDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1535
Query: 1524 HRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE-------------------G 1564
HRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTE G
Sbjct: 1536 HRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAG 1595
Query: 1565 NLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKE 1624
NLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKE
Sbjct: 1596 NLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKE 1655
Query: 1625 QGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDDV 1678
QGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL +E E EDD+
Sbjct: 1656 QGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDI 1714
Query: 1679 FKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCH 1738
F+R G L GNHV++ SD R + QT TT RPLH+ + DTE P +S
Sbjct: 1715 FRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-F 1772
Query: 1739 NHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRR 1798
+++S T +NAN+NNAN + RP+ + S H P R
Sbjct: 1773 TPSSYSS------TGSNANINNANNTALGRLPRPA----GYPSTVSTVEGHGPPLSPAIR 1822
Query: 1799 SSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYF-----RDPHCLGEQEYFSSEE-CY 1852
V+ + + R S + Q +E+ + D E S+E Y
Sbjct: 1823 --VQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSY 1880
Query: 1853 EDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLP 1912
+DD + Q L ++D D R+SP+R L
Sbjct: 1881 QDD-----------------------------ENRQLTLPEEDK---RDIRQSPKRGFL- 1907
Query: 1913 PTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKY 1972
+ + RR+SF+ ECL+RQ + +T LPLHL+ Q +AVAGL + +
Sbjct: 1908 RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSH 1962
Query: 1973 SPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP--- 2029
SP+ R +ATPPATP R W P P +++E E+ +++N S PS+H SW P
Sbjct: 1963 SPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGG 2022
Query: 2030 -DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEI 2088
+ R P SL VPS SA SLVEAVLISEGLG++A+DPKF+ T E+
Sbjct: 2023 GSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQEL 2082
Query: 2089 ADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR-- 2146
ADACD+TI+EMESAA +L+G NG + P + +D QD G D R
Sbjct: 2083 ADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGR 2141
Query: 2147 -DEEDLADEMICITTL 2161
EE+L D + +++L
Sbjct: 2142 PSEEELQDSRVYVSSL 2157
>gi|193788530 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 9 [Homo sapiens]
Length = 2157
Score = 2734 bits (7086), Expect = 0.0
Identities = 1453/2176 (66%), Positives = 1666/2176 (76%), Gaps = 133/2176 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN ILG DY
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF DAWNTFD+LIV+GSI+D+A
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1286 LSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1345
++E +P E + N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK
Sbjct: 1300 ITEVNPAEH----TQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1355
Query: 1346 SFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATG 1405
SFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATG
Sbjct: 1356 SFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATG 1415
Query: 1406 EAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVI 1463
EAWQ+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVI
Sbjct: 1416 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1475
Query: 1464 MDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1523
MDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP
Sbjct: 1476 MDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1535
Query: 1524 HRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE-------------------G 1564
HRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTE G
Sbjct: 1536 HRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAG 1595
Query: 1565 NLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKE 1624
NLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKE
Sbjct: 1596 NLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKE 1655
Query: 1625 QGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDDV 1678
QGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL +E E EDD+
Sbjct: 1656 QGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDI 1714
Query: 1679 FKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCH 1738
F+R G L GNHV++ SD R + QT TT RPLH+ + DTE P +S
Sbjct: 1715 FRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-F 1772
Query: 1739 NHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRR 1798
+++S T +NAN+NNAN + RP+ + S H P R
Sbjct: 1773 TPSSYSS------TGSNANINNANNTALGRLPRPA----GYPSTVSTVEGHGPPLSPAIR 1822
Query: 1799 SSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYF-----RDPHCLGEQEYFSSEE-CY 1852
V+ + + R S + Q +E+ + D E S+E Y
Sbjct: 1823 --VQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSY 1880
Query: 1853 EDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLP 1912
+DD + Q L ++D D R+SP+R L
Sbjct: 1881 QDD-----------------------------ENRQLTLPEEDK---RDIRQSPKRGFL- 1907
Query: 1913 PTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKY 1972
+ + RR+SF+ ECL+RQ + +T LPLHL+ Q +AVAGL + +
Sbjct: 1908 RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSH 1962
Query: 1973 SPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP--- 2029
SP+ R +ATPPATP R W P P +++E E+ +++N S PS+H SW P
Sbjct: 1963 SPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGG 2022
Query: 2030 -DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEI 2088
+ R P SL VPS SA SLVEAVLISEGLG++A+DPKF+ T E+
Sbjct: 2023 GSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQEL 2082
Query: 2089 ADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR-- 2146
ADACD+TI+EMESAA +L+G NG + P + +D QD G D R
Sbjct: 2083 ADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGR 2141
Query: 2147 -DEEDLADEMICITTL 2161
EE+L D + +++L
Sbjct: 2142 PSEEELQDSRVYVSSL 2157
>gi|193788720 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 1 [Homo sapiens]
Length = 2221
Score = 2733 bits (7084), Expect = 0.0
Identities = 1463/2213 (66%), Positives = 1681/2213 (75%), Gaps = 143/2213 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFD-- 923
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN IL YFD
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 924 ------------------YAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGV 965
Y FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV V
Sbjct: 940 FTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSV 999
Query: 966 SLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLL 1025
SL+SFGIQSSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLL
Sbjct: 1000 SLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLL 1059
Query: 1026 QFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFD 1085
QFMFACIGVQLFKGK Y C+D +K EC+G +I YKDG+VD P+++ R W+NS F+FD
Sbjct: 1060 QFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFD 1119
Query: 1086 NVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMN 1145
NVL+AMMALFTVSTFEGWP LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMN
Sbjct: 1120 NVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMN 1179
Query: 1146 IFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSS 1205
IFVGFVIVTFQEQGE+EYKNCELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+
Sbjct: 1180 IFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNST 1239
Query: 1206 PFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYF 1265
FEY+MFVLI+LNT+CLAMQHY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPKGYF
Sbjct: 1240 YFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYF 1299
Query: 1266 S----------------------------DAWNTFDSLIVIGSIIDVALSEADPTESENV 1297
S DAWNTFD+LIV+GSI+D+A++E +P E
Sbjct: 1300 SDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEH--- 1356
Query: 1298 PVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI 1357
+ N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI
Sbjct: 1357 -TQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI 1415
Query: 1358 AMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLP 1417
MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+P
Sbjct: 1416 VMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMP 1475
Query: 1418 GKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1475
GK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS
Sbjct: 1476 GKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1535
Query: 1476 ILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMN 1535
ILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLV+MN
Sbjct: 1536 ILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMN 1595
Query: 1536 MPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPP 1595
MPLNSDGTVMFNATLFALVRTAL+IKTEGNLEQANEELRA+IKKIWK+TSMKLLDQVVPP
Sbjct: 1596 MPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPP 1655
Query: 1596 AGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIR 1655
AGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAGLRTLHDIGPEIR
Sbjct: 1656 AGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAGLRTLHDIGPEIR 1714
Query: 1656 RAISCDLQDDE------PEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHR 1709
RAIS DL +E E EDD+F+R G L GNHV++ SD R + QT TT R
Sbjct: 1715 RAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQR 1774
Query: 1710 PLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHG 1769
PLH+ + DTE P +S +++S T +NAN+NNAN +
Sbjct: 1775 PLHINKAG-SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNANINNANNTALGRL 1826
Query: 1770 KRPSIGNLEHVSENGHH----SSHKHDREPQRRSSVKRTRYY----ETYIRSDSGDEQLP 1821
RP+ G VS H S +E + S R R+ + +R DSG
Sbjct: 1827 PRPA-GYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRERHVPMCEDLELRRDSGSAGTQ 1885
Query: 1822 TIC----REDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNID 1877
C + +P + QE S +E YE + N+ + +
Sbjct: 1886 AHCLLLRKANPSRCHSRESQAAMAGQEETSQDETYE-------VKMNHDTEACSEPSLLS 1938
Query: 1878 SE--RPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQE 1935
+E + + Q L ++D D R+SP+R L + + RR+SF+ ECL+RQ +
Sbjct: 1939 TEMLSYQDDENRQLTLPEEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQKDR- 1993
Query: 1936 EVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTP 1995
+T LPLHL+ Q +AVAGL + +SP+ R +ATPPATP R W P
Sbjct: 1994 ----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPP 2049
Query: 1996 CYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSFRNKN 2051
P +++E E+ +++N S PS+H SW P + R P SL VPS
Sbjct: 2050 QPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPG 2109
Query: 2052 SDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNGNV 2111
SA SLVEAVLISEGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L+G
Sbjct: 2110 RQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGA 2169
Query: 2112 RPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2161
NG + P + +D QD G D R EE+L D + +++L
Sbjct: 2170 PQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2221
>gi|193788528 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 8 [Homo sapiens]
Length = 2157
Score = 2733 bits (7084), Expect = 0.0
Identities = 1453/2176 (66%), Positives = 1664/2176 (76%), Gaps = 133/2176 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN IL YFD
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF DAWNTFD+LIV+GSI+D+A
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1286 LSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1345
++E +P E + N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK
Sbjct: 1300 ITEVNPAEH----TQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1355
Query: 1346 SFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATG 1405
SFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATG
Sbjct: 1356 SFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATG 1415
Query: 1406 EAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVI 1463
EAWQ+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVI
Sbjct: 1416 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1475
Query: 1464 MDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1523
MDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP
Sbjct: 1476 MDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1535
Query: 1524 HRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE-------------------G 1564
HRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTE G
Sbjct: 1536 HRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAG 1595
Query: 1565 NLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKE 1624
NLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKE
Sbjct: 1596 NLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKE 1655
Query: 1625 QGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDDV 1678
QGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL +E E EDD+
Sbjct: 1656 QGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDI 1714
Query: 1679 FKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCH 1738
F+R G L GNHV++ SD R + QT TT RPLH+ + DTE P +S
Sbjct: 1715 FRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-F 1772
Query: 1739 NHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRR 1798
+++S T +NAN+NNAN + RP+ + S H P R
Sbjct: 1773 TPSSYSS------TGSNANINNANNTALGRLPRPA----GYPSTVSTVEGHGPPLSPAIR 1822
Query: 1799 SSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYF-----RDPHCLGEQEYFSSEE-CY 1852
V+ + + R S + Q +E+ + D E S+E Y
Sbjct: 1823 --VQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSY 1880
Query: 1853 EDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLP 1912
+DD + Q L ++D D R+SP+R L
Sbjct: 1881 QDD-----------------------------ENRQLTLPEEDK---RDIRQSPKRGFL- 1907
Query: 1913 PTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKY 1972
+ + RR+SF+ ECL+RQ + +T LPLHL+ Q +AVAGL + +
Sbjct: 1908 RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSH 1962
Query: 1973 SPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP--- 2029
SP+ R +ATPPATP R W P P +++E E+ +++N S PS+H SW P
Sbjct: 1963 SPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGG 2022
Query: 2030 -DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEI 2088
+ R P SL VPS SA SLVEAVLISEGLG++A+DPKF+ T E+
Sbjct: 2023 GSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQEL 2082
Query: 2089 ADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR-- 2146
ADACD+TI+EMESAA +L+G NG + P + +D QD G D R
Sbjct: 2083 ADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGR 2141
Query: 2147 -DEEDLADEMICITTL 2161
EE+L D + +++L
Sbjct: 2142 PSEEELQDSRVYVSSL 2157
>gi|193788728 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 3 [Homo sapiens]
Length = 2179
Score = 2731 bits (7078), Expect = 0.0
Identities = 1457/2194 (66%), Positives = 1668/2194 (76%), Gaps = 147/2194 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN IL YFD
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF DAWNTFD+LIV+GSI+D+A
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1286 LSEADPTESEN-------------VPVPTATP-----GNSEESNRISITFFRLFRVMRLV 1327
++E +P E + V TA P N+EE++RISITFFRLFRVMRLV
Sbjct: 1300 ITEVNPAEHTQCSPSMGPSCSHPPLAVLTAPPVADGFQNAEENSRISITFFRLFRVMRLV 1359
Query: 1328 KLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNN 1387
KLLSRGEGIRTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNN
Sbjct: 1360 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1419
Query: 1388 NFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFI 1445
NFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK C PES+ + E CGS+FA+ YFI
Sbjct: 1420 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFI 1479
Query: 1446 SFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDV 1505
SFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDV
Sbjct: 1480 SFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDV 1539
Query: 1506 VTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE-- 1563
VTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTE
Sbjct: 1540 VTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEG 1599
Query: 1564 -----------------GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKF 1606
GNLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKF
Sbjct: 1600 PSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKF 1659
Query: 1607 YATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDE 1666
YATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL +E
Sbjct: 1660 YATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEE 1718
Query: 1667 ------PEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPP 1720
E EDD+F+R G L GNHV++ SD R + QT TT RPLH+ +
Sbjct: 1719 ELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG-SS 1777
Query: 1721 ASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHV 1780
DTE P +S +++S T +NAN+NNAN + RP+ +
Sbjct: 1778 QGDTESPSHEKLVDST-FTPSSYSS------TGSNANINNANNTALGRLPRPA----GYP 1826
Query: 1781 SENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYF-----R 1835
S H P R V+ + + R S + Q +E+ +
Sbjct: 1827 STVSTVEGHGPPLSPAIR--VQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNH 1884
Query: 1836 DPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDD 1894
D E S+E Y+DD + Q L ++
Sbjct: 1885 DTEACSEPSLLSTEMLSYQDD-----------------------------ENRQLTLPEE 1915
Query: 1895 DSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLM 1954
D D R+SP+R L + + RR+SF+ ECL+RQ + +T LPLHL+
Sbjct: 1916 DK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLHLV 1966
Query: 1955 QQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNG 2014
Q +AVAGL + +SP+ R +ATPPATP R W P P +++E E+ +++N
Sbjct: 1967 HHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNS 2026
Query: 2015 SLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEG 2070
S PS+H SW P + R P SL VPS SA SLVEAVLISEG
Sbjct: 2027 SFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEG 2086
Query: 2071 LGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYEL 2130
LG++A+DPKF+ T E+ADACD+TI+EMESAA +L+G NG + P + +D
Sbjct: 2087 LGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG- 2145
Query: 2131 QDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2161
QD G D R EE+L D + +++L
Sbjct: 2146 QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2179
>gi|193788534 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 12 [Homo sapiens]
Length = 2146
Score = 2727 bits (7070), Expect = 0.0
Identities = 1451/2176 (66%), Positives = 1663/2176 (76%), Gaps = 144/2176 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN ILG DY
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF DAWNTFD+LIV+GSI+D+A
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1286 LSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1345
++E + N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK
Sbjct: 1300 ITEVN---------------NAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1344
Query: 1346 SFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATG 1405
SFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATG
Sbjct: 1345 SFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATG 1404
Query: 1406 EAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVI 1463
EAWQ+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVI
Sbjct: 1405 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1464
Query: 1464 MDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1523
MDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP
Sbjct: 1465 MDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1524
Query: 1524 HRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE-------------------G 1564
HRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTE G
Sbjct: 1525 HRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAG 1584
Query: 1565 NLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKE 1624
NLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKE
Sbjct: 1585 NLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKE 1644
Query: 1625 QGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDDV 1678
QGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL +E E EDD+
Sbjct: 1645 QGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDI 1703
Query: 1679 FKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCH 1738
F+R G L GNHV++ SD R + QT TT RPLH+ + DTE P +S
Sbjct: 1704 FRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-F 1761
Query: 1739 NHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRR 1798
+++S T +NAN+NNAN + RP+ + S H P R
Sbjct: 1762 TPSSYSS------TGSNANINNANNTALGRLPRPA----GYPSTVSTVEGHGPPLSPAIR 1811
Query: 1799 SSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYF-----RDPHCLGEQEYFSSEE-CY 1852
V+ + + R S + Q +E+ + D E S+E Y
Sbjct: 1812 --VQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSY 1869
Query: 1853 EDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLP 1912
+DD + Q L ++D D R+SP+R L
Sbjct: 1870 QDD-----------------------------ENRQLTLPEEDK---RDIRQSPKRGFL- 1896
Query: 1913 PTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKY 1972
+ + RR+SF+ ECL+RQ + +T LPLHL+ Q +AVAGL + +
Sbjct: 1897 RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSH 1951
Query: 1973 SPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP--- 2029
SP+ R +ATPPATP R W P P +++E E+ +++N S PS+H SW P
Sbjct: 1952 SPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGG 2011
Query: 2030 -DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEI 2088
+ R P SL VPS SA SLVEAVLISEGLG++A+DPKF+ T E+
Sbjct: 2012 GSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQEL 2071
Query: 2089 ADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR-- 2146
ADACD+TI+EMESAA +L+G NG + P + +D QD G D R
Sbjct: 2072 ADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGR 2130
Query: 2147 -DEEDLADEMICITTL 2161
EE+L D + +++L
Sbjct: 2131 PSEEELQDSRVYVSSL 2146
>gi|193788532 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 11 [Homo sapiens]
Length = 2146
Score = 2727 bits (7068), Expect = 0.0
Identities = 1451/2176 (66%), Positives = 1661/2176 (76%), Gaps = 144/2176 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN IL YFD
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF DAWNTFD+LIV+GSI+D+A
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1286 LSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1345
++E + N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK
Sbjct: 1300 ITEVN---------------NAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1344
Query: 1346 SFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATG 1405
SFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATG
Sbjct: 1345 SFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATG 1404
Query: 1406 EAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVI 1463
EAWQ+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVI
Sbjct: 1405 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1464
Query: 1464 MDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1523
MDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP
Sbjct: 1465 MDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1524
Query: 1524 HRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE-------------------G 1564
HRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTE G
Sbjct: 1525 HRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAG 1584
Query: 1565 NLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKE 1624
NLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKE
Sbjct: 1585 NLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKE 1644
Query: 1625 QGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDDV 1678
QGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL +E E EDD+
Sbjct: 1645 QGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDI 1703
Query: 1679 FKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCH 1738
F+R G L GNHV++ SD R + QT TT RPLH+ + DTE P +S
Sbjct: 1704 FRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-F 1761
Query: 1739 NHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRR 1798
+++S T +NAN+NNAN + RP+ + S H P R
Sbjct: 1762 TPSSYSS------TGSNANINNANNTALGRLPRPA----GYPSTVSTVEGHGPPLSPAIR 1811
Query: 1799 SSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYF-----RDPHCLGEQEYFSSEE-CY 1852
V+ + + R S + Q +E+ + D E S+E Y
Sbjct: 1812 --VQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSY 1869
Query: 1853 EDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLP 1912
+DD + Q L ++D D R+SP+R L
Sbjct: 1870 QDD-----------------------------ENRQLTLPEEDK---RDIRQSPKRGFL- 1896
Query: 1913 PTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKY 1972
+ + RR+SF+ ECL+RQ + +T LPLHL+ Q +AVAGL + +
Sbjct: 1897 RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSH 1951
Query: 1973 SPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP--- 2029
SP+ R +ATPPATP R W P P +++E E+ +++N S PS+H SW P
Sbjct: 1952 SPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGG 2011
Query: 2030 -DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEI 2088
+ R P SL VPS SA SLVEAVLISEGLG++A+DPKF+ T E+
Sbjct: 2012 GSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQEL 2071
Query: 2089 ADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR-- 2146
ADACD+TI+EMESAA +L+G NG + P + +D QD G D R
Sbjct: 2072 ADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGR 2130
Query: 2147 -DEEDLADEMICITTL 2161
EE+L D + +++L
Sbjct: 2131 PSEEELQDSRVYVSSL 2146
>gi|193788724 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 2 [Homo sapiens]
Length = 2186
Score = 2726 bits (7067), Expect = 0.0
Identities = 1456/2205 (66%), Positives = 1669/2205 (75%), Gaps = 162/2205 (7%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFD-- 923
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN IL YFD
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 924 ------------------YAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGV 965
Y FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV V
Sbjct: 940 FTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSV 999
Query: 966 SLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLL 1025
SL+SFGIQSSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLL
Sbjct: 1000 SLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLL 1059
Query: 1026 QFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFD 1085
QFMFACIGVQLFKGK Y C+D +K EC+G +I YKDG+VD P+++ R W+NS F+FD
Sbjct: 1060 QFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFD 1119
Query: 1086 NVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMN 1145
NVL+AMMALFTVSTFEGWP LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMN
Sbjct: 1120 NVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMN 1179
Query: 1146 IFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSS 1205
IFVGFVIVTFQEQGE+EYKNCELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+
Sbjct: 1180 IFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNST 1239
Query: 1206 PFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYF 1265
FEY+MFVLI+LNT+CLAMQHY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPKGYF
Sbjct: 1240 YFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYF 1299
Query: 1266 S----------------------------DAWNTFDSLIVIGSIIDVALSEADPTESENV 1297
S DAWNTFD+LIV+GSI+D+A++E +P E
Sbjct: 1300 SDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEH--- 1356
Query: 1298 PVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI 1357
+ N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI
Sbjct: 1357 -TQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI 1415
Query: 1358 AMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLP 1417
MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+P
Sbjct: 1416 VMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMP 1475
Query: 1418 GKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1475
GK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS
Sbjct: 1476 GKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1535
Query: 1476 ILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMN 1535
ILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLV+MN
Sbjct: 1536 ILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMN 1595
Query: 1536 MPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPP 1595
MPLNSDGTVMFNATLFALVRTAL+IKTEGNLEQANEELRA+IKKIWK+TSMKLLDQVVPP
Sbjct: 1596 MPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPP 1655
Query: 1596 AGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIR 1655
AGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAGLRTLHDIGPEIR
Sbjct: 1656 AGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAGLRTLHDIGPEIR 1714
Query: 1656 RAISCDLQDDE------PEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHR 1709
RAIS DL +E E EDD+F+R G L GNHV++ SD R + QT TT R
Sbjct: 1715 RAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQR 1774
Query: 1710 PLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHG 1769
PLH+ + DTE P +S +++S T +NAN+NNAN +
Sbjct: 1775 PLHINKAG-SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNANINNANNTALGRL 1826
Query: 1770 KRPSIGNLEHVSENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQLPTICREDPE 1829
RP+ + S H P R V+ + + R S + Q +E+
Sbjct: 1827 PRPA----GYPSTVSTVEGHGPPLSPAIR--VQEVAWKLSSNRCHSRESQAAMAGQEETS 1880
Query: 1830 IHGYF-----RDPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRG 1883
+ D E S+E Y+DD
Sbjct: 1881 QDETYEVKMNHDTEACSEPSLLSTEMLSYQDD---------------------------- 1912
Query: 1884 YHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIF 1943
+ Q L ++D D R+SP+R L + + RR+SF+ ECL+RQ +
Sbjct: 1913 -ENRQLTLPEEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQKDR-----GGDI 1962
Query: 1944 PHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQV 2003
+T LPLHL+ Q +AVAGL + +SP+ R +ATPPATP R W P P +++
Sbjct: 1963 SQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRL 2022
Query: 2004 EQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSFRNKNSDKQRSAD 2059
E E+ +++N S PS+H SW P + R P SL VPS SA
Sbjct: 2023 EGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSAS 2082
Query: 2060 SLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDV 2119
SLVEAVLISEGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L+G NG +
Sbjct: 2083 SLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGAL 2142
Query: 2120 GPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2161
P + +D QD G D R EE+L D + +++L
Sbjct: 2143 LPFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2186
>gi|193794832 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoforom 13 [Homo sapiens]
Length = 2144
Score = 2726 bits (7065), Expect = 0.0
Identities = 1451/2176 (66%), Positives = 1660/2176 (76%), Gaps = 146/2176 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN IL YFD
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF DAWNTFD+LIV+GSI+D+A
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1286 LSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1345
++E N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK
Sbjct: 1300 ITE-----------------NAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1342
Query: 1346 SFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATG 1405
SFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATG
Sbjct: 1343 SFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATG 1402
Query: 1406 EAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVI 1463
EAWQ+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVI
Sbjct: 1403 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1462
Query: 1464 MDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1523
MDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP
Sbjct: 1463 MDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1522
Query: 1524 HRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE-------------------G 1564
HRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTE G
Sbjct: 1523 HRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAG 1582
Query: 1565 NLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKE 1624
NLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKE
Sbjct: 1583 NLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKE 1642
Query: 1625 QGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDDV 1678
QGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL +E E EDD+
Sbjct: 1643 QGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDI 1701
Query: 1679 FKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCH 1738
F+R G L GNHV++ SD R + QT TT RPLH+ + DTE P +S
Sbjct: 1702 FRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-F 1759
Query: 1739 NHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRR 1798
+++S T +NAN+NNAN + RP+ + S H P R
Sbjct: 1760 TPSSYSS------TGSNANINNANNTALGRLPRPA----GYPSTVSTVEGHGPPLSPAIR 1809
Query: 1799 SSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYF-----RDPHCLGEQEYFSSEE-CY 1852
V+ + + R S + Q +E+ + D E S+E Y
Sbjct: 1810 --VQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSY 1867
Query: 1853 EDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLP 1912
+DD + Q L ++D D R+SP+R L
Sbjct: 1868 QDD-----------------------------ENRQLTLPEEDK---RDIRQSPKRGFL- 1894
Query: 1913 PTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKY 1972
+ + RR+SF+ ECL+RQ + +T LPLHL+ Q +AVAGL + +
Sbjct: 1895 RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSH 1949
Query: 1973 SPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP--- 2029
SP+ R +ATPPATP R W P P +++E E+ +++N S PS+H SW P
Sbjct: 1950 SPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGG 2009
Query: 2030 -DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEI 2088
+ R P SL VPS SA SLVEAVLISEGLG++A+DPKF+ T E+
Sbjct: 2010 GSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQEL 2069
Query: 2089 ADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR-- 2146
ADACD+TI+EMESAA +L+G NG + P + +D QD G D R
Sbjct: 2070 ADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGR 2128
Query: 2147 -DEEDLADEMICITTL 2161
EE+L D + +++L
Sbjct: 2129 PSEEELQDSRVYVSSL 2144
>gi|53832007 calcium channel, voltage-dependent, L type, alpha 1F
subunit [Homo sapiens]
Length = 1977
Score = 2390 bits (6195), Expect = 0.0
Identities = 1201/1636 (73%), Positives = 1357/1636 (82%), Gaps = 71/1636 (4%)
Query: 83 RKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVA 142
++R Q++K K +S R RALFCL+L NP+RR+CISIVEWKPFDI ILL IFANCVA
Sbjct: 49 KRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVA 108
Query: 143 LAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDF 202
L +YIPFPEDDSN+ NHNLE+VEY FL+IFTVET LKI+AYGL+LHP+AY+RNGWNLLDF
Sbjct: 109 LGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDF 168
Query: 203 VIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLN 262
+IV+VGLFSV+LEQ H+ GK GGFDVKALRAFRVLRPLRLVSGVPSL +VLN
Sbjct: 169 IIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLN 228
Query: 263 SIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGN 322
SI+KA+VPLLHIALLVLFVIIIYAIIGLELF+G+MHKTC+F SD+ AEEDP+PCA SG+
Sbjct: 229 SIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGS 288
Query: 323 GRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELP 382
GR CT N TECR W GPNGGITNFDNF FAMLTVFQC+TMEGWTDVLYWM DAMG+ELP
Sbjct: 289 GRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELP 348
Query: 383 WVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWI 442
WVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQK REKQQ+EEDL+GYLDWI
Sbjct: 349 WVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWI 408
Query: 443 TQAEDIDPENEE---------EGGEEGKR-----------------------------NT 464
TQAE++D E+ E G G R +
Sbjct: 409 TQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRSTHSTSSHA 468
Query: 465 SMPTSETESVNTENVSGEGENRGC---CGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVK 521
S+P S+T S+ TE E E G C I K+++ RR RR NR R RCR AVK
Sbjct: 469 SLPASDTGSM-TETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRARCRRAVK 527
Query: 522 SVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQA 581
S YW V++LVFLNTLTI+SEH+ QP WLTQIQ+ ANKVLL LFT EML+K+Y LG A
Sbjct: 528 SNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSA 587
Query: 582 YFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVA 641
Y S FNRFDCFVVCGGI ET LVE+ M PLGISV RCVRLLRIFKVTRHW SLSNLVA
Sbjct: 588 YVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVA 647
Query: 642 SLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQI 701
SLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD+T TKRSTFD FPQALLTVFQI
Sbjct: 648 SLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQALLTVFQI 707
Query: 702 LTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESL 761
LTGEDWN VMYDGIMAYGGP GM+VCIYFIILFICGNYILLNVFLAIAVDNLA ++
Sbjct: 708 LTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDA- 766
Query: 762 NTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPC 821
TA+ + E+ K + + +N+ + +E+E+
Sbjct: 767 GTAKDKGGEKSNEKDLPQ--------------------ENEGLVPGVEKEEEEGARREGA 806
Query: 822 DVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHK 881
D+ EEEEEEEE+E E + E+ KEK+ PIPEGSAFF LS+TNP+R GCH
Sbjct: 807 DMEEEEEEEEEEEEEEEEEGAGGVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHT 866
Query: 882 LINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTF 941
LI+HH+FTNLILVFI+LSS +LAAEDPIR+HSFRN ILGYFDYAFT+IFTVEILLKMT F
Sbjct: 867 LIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVF 926
Query: 942 GAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGL 1001
GAFLH+G+FCR++FN+LD+LVV VSL+SFGI SSAISVVKILRVLRVLRPLRAINRAKGL
Sbjct: 927 GAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVKILRVLRVLRPLRAINRAKGL 986
Query: 1002 KHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFIL 1061
KHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY CTDEAK P+EC+G F++
Sbjct: 987 KHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLV 1046
Query: 1062 YKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPI 1121
Y DGDV P+VRER+W NSDFNFDNVLSAMMALFTVSTFEGWPALLYKAID+ E+ GPI
Sbjct: 1047 YPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPI 1106
Query: 1122 YNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALK 1181
YN+RVEIS+FFI+YIII+AFFMMNIFVGFVI+TF+ QGE+EY+NCELDKNQRQCVEYALK
Sbjct: 1107 YNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALK 1166
Query: 1182 ARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILN 1241
A+PLRRYIPKNP+QY+ W VNS+ FEY+MF+LI+LNT+ LAMQHYEQ+ FN AMDILN
Sbjct: 1167 AQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILN 1226
Query: 1242 MVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPT 1301
MVFTG+FT+EMVLK+IAFKPK YF+DAWNTFD+LIV+GSI+D+A++E +
Sbjct: 1227 MVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGH------- 1279
Query: 1302 ATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLF 1361
+SE+S+RISITFFRLFRVMRLVKLLS+GEGIRTLLWTFIKSFQALPYVALLIAM+F
Sbjct: 1280 -LGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIF 1338
Query: 1362 FIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLC 1421
FIYAVIGMQMFGKVA++D QINRNNNFQTFPQAVLLLFRCATGEAWQEIMLA LPG C
Sbjct: 1339 FIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRC 1398
Query: 1422 DPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHH 1481
DPESD+ PGEE+TCGSNFAI YFISF+MLCAFLIINLFVAVIMDNFDYLTRDWSILGPHH
Sbjct: 1399 DPESDFGPGEEFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHH 1458
Query: 1482 LDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSD 1541
LDEFKRIWSEYDP AKGRIKHLDVV LLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSD
Sbjct: 1459 LDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSD 1518
Query: 1542 GTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEV 1601
GTV FNATLFALVRT+LKIKTEGNLEQAN+ELR VIKKIWK+ KLLD+V+PP ++EV
Sbjct: 1519 GTVTFNATLFALVRTSLKIKTEGNLEQANQELRIVIKKIWKRMKQKLLDEVIPPPDEEEV 1578
Query: 1602 TVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCD 1661
TVGKFYATFLIQDYFRKF++RKE+GL+G A +T+ ALQAGLR+L D+GPE+R+A++CD
Sbjct: 1579 TVGKFYATFLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAGLRSLQDLGPEMRQALTCD 1638
Query: 1662 LQDDEPEETKREEEDD 1677
+++E E + EE+D
Sbjct: 1639 TEEEEEEGQEGVEEED 1654
Score = 135 bits (340), Expect = 4e-31
Identities = 105/262 (40%), Positives = 128/262 (48%), Gaps = 67/262 (25%)
Query: 1901 DSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMA 1960
D PRRRLLPPTPA R+ SF +CL+RQ S E++P + HR
Sbjct: 1782 DGHLVPRRRLLPPTPAG-RKPSFTIQCLQRQGSCEDLPIPGTY-HR-------------- 1825
Query: 1961 VAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLH 2020
+ P+ + SWATPP Y PL+ VE+ A + G
Sbjct: 1826 --------GRNSGPNRAQGSWATPPQRGRL-----LYAPLLLVEEGAAGEGYLG------ 1866
Query: 2021 RSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKF 2080
RSS RTFT L VP + + + K+ SADSLVEAVLISEGLG +ARDP+F
Sbjct: 1867 RSSG-------PLRTFT--CLHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARDPRF 1917
Query: 2081 VSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDE 2140
V+ K EIADAC LT+DEM++AAS LL Q YSDE
Sbjct: 1918 VALAKQEIADACRLTLDEMDNAASDLL----------------------AQGTSSLYSDE 1955
Query: 2141 EPDPGR-DEEDLADEMICITTL 2161
E R DEEDL DEM C+ L
Sbjct: 1956 ESILSRFDEEDLGDEMACVHAL 1977
>gi|110349767 calcium channel, voltage-dependent, L type, alpha 1S
subunit [Homo sapiens]
Length = 1873
Score = 2268 bits (5878), Expect = 0.0
Identities = 1167/1764 (66%), Positives = 1376/1764 (78%), Gaps = 91/1764 (5%)
Query: 69 MSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPF 128
M S+P G RK+Q KK RP RALFCL+L NP+R+ACISIVEWKPF
Sbjct: 1 MEPSSPQDEGL---RKKQP----KKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPF 53
Query: 129 DIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLH 188
+ ILL IFANCVALA+Y+P PEDD+NS N LEK+EY FLI+F++E +KIIAYG L H
Sbjct: 54 ETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFH 113
Query: 189 PNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPL 248
+AY+R+GWN+LDF IV +G+F+VILEQ+ S K G DVKALRAFRVLRPL
Sbjct: 114 QDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPL 173
Query: 249 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDI 308
RLVSGVPSLQVVLNSI KAM+PL HIALLVLF++IIYAIIGLELF GKMHKTC+F +DI
Sbjct: 174 RLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDI 233
Query: 309 VA---EEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEG 365
VA E+P+PCA +G+GR+CT NG+ECR GW GPN GIT+FDNF F+MLTV+QCITMEG
Sbjct: 234 VATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEG 293
Query: 366 WTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 425
WTDVLYW+NDA+G E PW+YFV+L++ GSFF+LNLVLGVLSGEF+KEREKAK+RG FQKL
Sbjct: 294 WTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKL 353
Query: 426 REKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVSGEGEN 485
REKQQL+EDL+GY+ WITQ E +D E+ EG K + S+TES+ ++G
Sbjct: 354 REKQQLDEDLRGYMSWITQGEVMDVEDFREG----KLSLDEGGSDTESLY--EIAG---- 403
Query: 486 RGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHY 545
+ Q I R WR+WNR R +C VKS FYWLVI++V LNTL+I+SEH+
Sbjct: 404 ---LNKIIQFI------RHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHH 454
Query: 546 NQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILV 605
NQP WLT++QDIAN+VLL+LFT EML+KMY LGL+ YF+S+FNRFDCFVVC GI E +LV
Sbjct: 455 NQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLV 514
Query: 606 ELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFS 665
E M+PLGISV RC+RLLRIFK+T++WTSLSNLVASLLNS++SIASLLLLLFLFI+IF+
Sbjct: 515 ESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFA 574
Query: 666 LLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSG 725
LLGMQLFGG+++F++T+ +RS FDNFPQAL++VFQ+LTGEDW ++MY+GIMAYGGPS G
Sbjct: 575 LLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPG 634
Query: 726 MIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIAR------ 779
M+VCIYFIILF+CGNYILLNVFLAIAVDNLA+AESL +AQK +AEEK+R+K+++
Sbjct: 635 MLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSKGLPDKS 694
Query: 780 ---KESLENKKNNKPEVNQIANSDNKVTIDDYREE-DEDKDPYPPCDVPVGEEEEEEEED 835
K ++ K KP+ I + K+ ID++ +E KDPYP D P ++EED
Sbjct: 695 EEEKSTMAKKLEQKPKGEGIPTTA-KLKIDEFESNVNEVKDPYPSADFP-----GDDEED 748
Query: 836 EPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVF 895
EPE+P PRPR ++EL +KEK PIPE S+FFI S TN IRV CH+++N FTN IL+F
Sbjct: 749 EPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLF 808
Query: 896 IMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYF 955
I+LSSAALAAEDPIR+ S RN IL +FD FT++FTVEI+LKMTT+GAFLHKG+FCRNYF
Sbjct: 809 ILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYF 868
Query: 956 NLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 1015
N+LD+LVV VSL+S G++SSAISVVKILRVLRVLRPLRAINRAKGLKHVVQC+FVAI TI
Sbjct: 869 NMLDLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTI 928
Query: 1016 GNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRER 1075
GNI++VTTLLQFMFACIGVQLFKGKF+RCTD +K EECRG + +YKDGD +R R
Sbjct: 929 GNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHR 988
Query: 1076 IWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIY 1135
W +SDF+FDNVLSAMM+LFTVSTFEGWP LLYKAIDSN E++GPIYN+RVE++IFFIIY
Sbjct: 989 EWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIY 1048
Query: 1136 IIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQ 1195
II++AFFMMNIFVGFVIVTFQEQGE EYKNCELDKNQRQCV+YALKARPLR YIPKNPYQ
Sbjct: 1049 IILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQ 1108
Query: 1196 YKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLK 1255
Y+ WY+V SS FEY+MF LIMLNT+CL MQHY QS+ N DILN+ FT +FT+EM+LK
Sbjct: 1109 YQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILK 1168
Query: 1256 VIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPG----NSEESN 1311
++AFK +GYF D WN FD LIVIGSIIDV LSE D + + + G + +ES
Sbjct: 1169 LMAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESA 1228
Query: 1312 RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQM 1371
RIS FFRLFRVMRL+KLLSR EG+RTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQM
Sbjct: 1229 RISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQM 1288
Query: 1372 FGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE 1431
FGK+A+ D QINRNNNFQTFPQAVLLLFRCATGEAWQEI+LAC GKLCDPESDY PGE
Sbjct: 1289 FGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGE 1348
Query: 1432 EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSE 1491
EYTCG+NFA YFISFYMLCAFL+INLFVAVIMDNFDYLTRDWSILGPHHLDEFK IW+E
Sbjct: 1349 EYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAE 1408
Query: 1492 YDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLF 1551
YDPEAKGRIKHLDVVTLLRRIQPPLGFGK CPHRVACKRLV MNMPLNSDGTV FNATLF
Sbjct: 1409 YDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLF 1468
Query: 1552 ALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFL 1611
ALVRTALKIKTEGN EQANEELRA+IKKIWK+TSMKLLDQV+PP GDDEVTVGKFYATFL
Sbjct: 1469 ALVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFL 1528
Query: 1612 IQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTL-HDIGPEIRRAISCDLQDDEPEET 1670
IQ++FRKF KR+E+ Y K + +QAGLRT+ + PEI R +S DL +E E
Sbjct: 1529 IQEHFRKFMKRQEE--YYGYRPKKDIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEELER 1586
Query: 1671 KREE---EDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKP 1727
E E+ +F+R G L G N + +R +SL RPL + + E P
Sbjct: 1587 AMVEAAMEEGIFRRTGGLFGQVDNFL--ERTNSLPPVMANQRPLQFAEIEM---EEMESP 1641
Query: 1728 LF------PPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVS 1781
+F P N + AN NNAN + A GN H +
Sbjct: 1642 VFLEDFPQDPRTNPL-----------------ARANTNNANANVA-------YGNSNHSN 1677
Query: 1782 ENGHHSSHKHDREPQRRSSVKRTR 1805
+ S H ++RE + TR
Sbjct: 1678 SHVFSSVH-YEREFPEETETPATR 1700
Score = 47.0 bits (110), Expect = 2e-04
Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 5/85 (5%)
Query: 2034 RTFTPASL--TVPSSFRNKNSDKQRSADS---LVEAVLISEGLGRYARDPKFVSATKHEI 2088
++ TP SL P S + + + SA + L++ L+ GLG A D F+ AT +
Sbjct: 1755 KSSTPGSLHEETPHSRSTRENTSRCSAPATALLIQKALVRGGLGTLAADANFIMATGQAL 1814
Query: 2089 ADACDLTIDEMESAASTLLNGNVRP 2113
ADAC + +E+E A+ LL G P
Sbjct: 1815 ADACQMEPEEVEIMATELLKGREAP 1839
>gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo
sapiens]
Length = 2261
Score = 773 bits (1997), Expect = 0.0
Identities = 399/825 (48%), Positives = 552/825 (66%), Gaps = 56/825 (6%)
Query: 820 PCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGC 879
P +P EEE++EEE++ GP+P +P S+ FILS TNP+R C
Sbjct: 1192 PDPLPKKEEEKKEEEEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLC 1237
Query: 880 HKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMT 939
H ++N F IL+ I +SS ALAAEDP++ ++ RN +L YFDY FT +FT E+++KM
Sbjct: 1238 HYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMI 1297
Query: 940 TFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSA----ISVVKILRVLRVLRPLRAI 995
G LH+GA+ R+ +N+LD +VV +LV+F ++ I+ +K LRVLRVLRPL+ I
Sbjct: 1298 DLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTI 1357
Query: 996 NRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEEC 1055
R LK V CV +++ + NI+IV L F+FA + VQLFKGKF+ CTDE+K ++C
Sbjct: 1358 KRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC 1417
Query: 1056 RGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNG 1115
RG ++LY+ +V + R+R W+ +F++DNVL A++ LFTVST EGWP +L ++D+
Sbjct: 1418 RGKYLLYEKNEVKA---RDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
Query: 1116 ENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQC 1175
EN GP +R+E+SIF+++Y ++ FF +NIFV +I+TFQEQG+K + L+KN+R C
Sbjct: 1475 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERAC 1534
Query: 1176 VEYALKARPLRRYIPKNP--YQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMF 1233
+++A+ A+PL R++P+N +QY+ W V S PFEY + +I LNT+ L M+ Y S +
Sbjct: 1535 IDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAY 1594
Query: 1234 NDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTE 1293
+A+ + N+VFT +F++E VLKV+AF YF DAWN FD + V+GSI D+ ++E
Sbjct: 1595 ENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEF---- 1650
Query: 1294 SENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYV 1353
GN N I+++F RLFR RL+KLL +G IR LLWTF++SF+ALPYV
Sbjct: 1651 -----------GN----NFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1695
Query: 1354 ALLIAMLFFIYAVIGMQMFGKVAM--------RDNNQINRNNNFQTFPQAVLLLFRCATG 1405
LLIAMLFFIYA+IGMQ+FG + + D QI +NNF+TF QA++LLFR ATG
Sbjct: 1696 CLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATG 1755
Query: 1406 EAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMD 1465
EAW IML+CL GK CD S E CG+ FA YF+SF LC+FL++NLFVAVIMD
Sbjct: 1756 EAWHNIMLSCLSGKPCDKNSGILTRE---CGNEFAYFYFVSFIFLCSFLMLNLFVAVIMD 1812
Query: 1466 NFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHR 1525
NF+YLTRD SILGPHHLDE+ R+W+EYDP A GRI + D+ +LLR I PPLG GK CPHR
Sbjct: 1813 NFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHR 1872
Query: 1526 VACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE---GNLEQANEELRAVIKKIWK 1582
VACKRL+ M++P+ D TV FN+TL AL+RTAL IK + +Q + ELR + IW
Sbjct: 1873 VACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWP 1932
Query: 1583 KTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGL 1627
S K LD +V P ++TVGK YA +I +Y+R+ K +K Q +
Sbjct: 1933 NLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAM 1977
Score = 654 bits (1686), Expect = 0.0
Identities = 354/724 (48%), Positives = 470/724 (64%), Gaps = 39/724 (5%)
Query: 104 RALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEK 163
R+LF S +N +R+ I EW PF+ IL I ANC+ LA+ P+DD + L+
Sbjct: 76 RSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDD 135
Query: 164 VEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEG 223
E F+ IF E +KIIA G H +Y+RNGWN++DFV+V+ G+ + + +
Sbjct: 136 TEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------- 188
Query: 224 GNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 283
FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAM+PLL I LL+ F I+
Sbjct: 189 ----------FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAIL 238
Query: 284 IYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGG 343
I+AIIGLE ++GK H TCF +D + E PAPC R C NGT+C+ W GPN G
Sbjct: 239 IFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCP-NGTKCQPYWEGPNNG 297
Query: 344 ITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLG 403
IT FDN FA+LTVFQCITMEGWTD+LY NDA G W+YF+ L+I GSFF+LNLVLG
Sbjct: 298 ITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLG 357
Query: 404 VLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEE---- 459
VLSGEF+KERE+ + R F KLR +QQ+E +L GY++WI++AE++ +E GE+
Sbjct: 358 VLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPF 417
Query: 460 --GKRNTSMPTSETESVNTENVSGEGENRGCCGS--LCQAISKSKL--SRRWRRWNRFNR 513
R T++ S+T+ +N E + + GS +I +KL S + + R R
Sbjct: 418 DGALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMR 477
Query: 514 RRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVK 573
R VK+ FYW V+ LV LNTL ++ HYNQP+WL+ A + L LF EM +K
Sbjct: 478 FYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIK 537
Query: 574 MYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHW 633
MY LG + YF S FN FDC V+ G I E I ++ + GISV R +RLLRIFKVT++W
Sbjct: 538 MYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYW 597
Query: 634 TSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQ 693
SL NLV SLLNSMKSI SLL LLFLFI++F+LLGMQLFGG+FNFDE T + FD FP
Sbjct: 598 ASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDE-GTPPTNFDTFPA 656
Query: 694 ALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVD 753
A++TVFQILTGEDWN VMYDGI + GG GM+ IYFI+L + GNY LLNVFLAIAVD
Sbjct: 657 AIMTVFQILTGEDWNEVMYDGIKSQGG-VQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVD 715
Query: 754 NLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDE 813
NLA+A+ L T ++E EE +K+A +++ E EV+ ++ ++ + + +E+ +
Sbjct: 716 NLANAQEL-TKDEQEEEEAANQKLALQKAKE-----VAEVSPLSAANMSIAV---KEQQK 766
Query: 814 DKDP 817
++ P
Sbjct: 767 NQKP 770
Score = 217 bits (552), Expect = 1e-55
Identities = 180/719 (25%), Positives = 329/719 (45%), Gaps = 121/719 (16%)
Query: 67 QTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWK 126
Q + P P+ + K+++ + + P ++F LS NP+RR C I+ +
Sbjct: 1185 QVNKNANPDPLPKKEEEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLR 1244
Query: 127 PFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLL 186
F++ IL+ I + +ALA P + N+ L +Y F +FT E +K+I GL+
Sbjct: 1245 YFEMCILMVIAMSSIALAAEDPVQPNAPR--NNVLRYFDYVFTGVFTFEMVIKMIDLGLV 1302
Query: 187 LHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFD---VKALRAFR 243
LH AY R+ WN+LDF++V L + +G S G D +K+LR R
Sbjct: 1303 LHQGAYFRDLWNILDFIVVSGALVAFAF-------------TGNSKGKDINTIKSLRVLR 1349
Query: 244 VLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFF 303
VLRPL+ + +P L+ V + ++ ++ + +I ++ + + I+A++ ++LF GK FF
Sbjct: 1350 VLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGK-----FF 1404
Query: 304 ADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITM 363
+D ++E C G+ E ++ ++DN +A+LT+F T
Sbjct: 1405 HCTD-ESKEFEKDC----RGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTG 1459
Query: 364 EGWTDVLYWMNDA----------MGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKER 413
EGW VL DA E+ Y V V+F FFV N+ + ++ F ++
Sbjct: 1460 EGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFV-NIFVALIIITFQEQ- 1517
Query: 414 EKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETES 473
GD K+ E+ LE++ + +D+ A+
Sbjct: 1518 ------GD--KMMEEYSLEKNERACIDFAISAK--------------------------- 1542
Query: 474 VNTENVSGEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLV 533
L + + ++K S ++R W V S F + ++ ++
Sbjct: 1543 -----------------PLTRHMPQNKQSFQYRMWQ---------FVVSPPFEYTIMAMI 1576
Query: 534 FLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCF 593
LNT+ + + Y + N V +LF+ E ++K+ + G+ YF +N FD
Sbjct: 1577 ALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFV 1636
Query: 594 VVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASL 653
V G IT+ ++ E + + +S R R R+ K+ R ++ L+ + + S K++ +
Sbjct: 1637 TVLGSITDILVTEFG-NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1695
Query: 654 LLLLFLFIIIFSLLGMQLFGG--------KFNFDETQ-TKRSTFDNFPQALLTVFQILTG 704
LL+ + I++++GMQ+FG + DE Q T+ + F F QAL+ +F+ TG
Sbjct: 1696 CLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATG 1755
Query: 705 EDWNAVMYDGIMAYGGPSSSGMI--------VCIYFI-ILFICGNYILLNVFLAIAVDN 754
E W+ +M + +SG++ YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 1756 EAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
Score = 188 bits (477), Expect = 6e-47
Identities = 169/706 (23%), Positives = 297/706 (42%), Gaps = 153/706 (21%)
Query: 865 AFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAED--PIRSHSFRNTILGYF 922
+ F+ S+ N +R K+ F +IL I+ + LA E P + + L
Sbjct: 77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
Query: 923 DYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVS-LVSFGIQSSAISVVK 981
+ F IF E +K+ G HKG++ RN +N++D +VV L + G + ++
Sbjct: 137 EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
Query: 982 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1041
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ +FA IG++ + GKF
Sbjct: 193 TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
Query: 1042 YR-CTDEAKSNPEECRGLFILYKDGDVDSPVVRER-------------IWQ---NSDFNF 1084
+ C +E + + G+ +P E W+ N F
Sbjct: 253 HTTCFEEGTDDIQ-----------GESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQF 301
Query: 1085 DNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMM 1144
DN+L A++ +F T EGW LLY + D++G +Y FI III +FFM+
Sbjct: 302 DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLY---------FIPLIIIGSFFML 352
Query: 1145 NIFVG------------------FVIVTFQEQGEKEYKNC---------------ELDKN 1171
N+ +G F+ + Q+Q E+E E D
Sbjct: 353 NLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGE 412
Query: 1172 QRQCVEYALKARPLRR---------------------------------------YIPKN 1192
QR + AL+ +++ + K
Sbjct: 413 QRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKK 472
Query: 1193 PYQYKFWY--VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTV 1250
+ +F+ +V + F + + L+ LNTLC+A+ HY Q + +D + +F G+F
Sbjct: 473 ERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMS 532
Query: 1251 EMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEES 1310
EM +K+ + YF ++N FD ++IGSI +V + P S
Sbjct: 533 EMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTS---------------- 576
Query: 1311 NRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQ 1370
I+ R R++R+ K+ +R L+ + + S +++ + L+ + ++A++GMQ
Sbjct: 577 --FGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQ 634
Query: 1371 MFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPG 1430
+FG D NF TFP A++ +F+ TGE W E+M D
Sbjct: 635 LFGGQFNFDEG--TPPTNFDTFPAAIMTVFQILTGEDWNEVMY------------DGIKS 680
Query: 1431 EEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1473
+ G +YFI + + ++N+F+A+ +DN LT+D
Sbjct: 681 QGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
Score = 139 bits (349), Expect = 4e-32
Identities = 177/787 (22%), Positives = 321/787 (40%), Gaps = 169/787 (21%)
Query: 479 VSGEGENRGCCGSL------CQAISKSKLSRRWRRWNRFN----RRRC------------ 516
V G G RG GS Q + K +++R R +N R+ C
Sbjct: 24 VVGSGGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSE 83
Query: 517 ----RAAVKSVT----FYWLVIVLVFLNTLTISSEHYNQPDWLTQIQ---DIANKVLLAL 565
R K +T F ++++ + N + ++ E + D T + D + +
Sbjct: 84 DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 143
Query: 566 FTCEMLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCV 621
F E +K+ +LG +Y + +N D VV GI T+ E ++ + R V
Sbjct: 144 FCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT------LRAV 197
Query: 622 RLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFN---F 678
R+LR K+ SL ++ S++ +M + + LLLF I+IF+++G++ + GKF+ F
Sbjct: 198 RVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF 257
Query: 679 DE--------------TQTKRST--------------------FDNFPQALLTVFQILTG 704
+E T+ T FDN A+LTVFQ +T
Sbjct: 258 EEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITM 317
Query: 705 EDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTA 764
E W ++Y+ A G + +YFI L I G++ +LN+ L + A
Sbjct: 318 EGWTDLLYNSNDASGNTWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEFAK------- 365
Query: 765 QKEEAEEKER-KKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPC-- 821
++E E + K+ R++ +E + N E I+ ++ + +D + E + P+
Sbjct: 366 ERERVENRRAFLKLRRQQQIERELNGYME--WISKAEEVILAED-ETDGEQRHPFDGALR 422
Query: 822 ---------DVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKT 872
D+ EE E++ D V + I + E S FF K
Sbjct: 423 RTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKL--------ENSTFFH-KKE 473
Query: 873 NPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTV 932
+R +++ F +L + L++ +A + + L Y ++ F +F
Sbjct: 474 RRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH-YNQPEWLSDFLYYAEFIFLGLFMS 532
Query: 933 EILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSL--VSFGIQSSAISV-VKILRVLRVL 989
E+ +KM G + + FN D V+ S+ V + + S + +LR LR+L
Sbjct: 533 EMFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLL 588
Query: 990 RPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAK 1049
R + L+++V + ++++I +++ + L +FA +G+QLF G+F
Sbjct: 589 RIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF-------- 640
Query: 1050 SNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYK 1109
+ D +P NFD +A+M +F + T E W ++Y
Sbjct: 641 --------------NFDEGTPPT----------NFDTFPAAIMTVFQILTGEDWNEVMYD 676
Query: 1110 AIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVI--------VTFQEQGEK 1161
I S G G + SI+FI+ + + ++N+F+ + +T EQ E+
Sbjct: 677 GIKSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEE 731
Query: 1162 EYKNCEL 1168
E N +L
Sbjct: 732 EAANQKL 738
Score = 80.9 bits (198), Expect = 1e-14
Identities = 74/296 (25%), Positives = 131/296 (44%), Gaps = 61/296 (20%)
Query: 127 PFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLL 186
PF+ I+ I N + L + S + + L F +F++E LK++A+G+L
Sbjct: 1567 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1623
Query: 187 LHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLR 246
Y R+ WN+ DFV V+ + +++ TE GN+ ++ LR FR R
Sbjct: 1624 ----NYFRDAWNIFDFVTVLGSITDILV------TEFGNNF------INLSFLRLFRAAR 1667
Query: 247 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADS 306
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F G + DS
Sbjct: 1668 LIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-GNIGIDVEDEDS 1726
Query: 307 DIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGW 366
D ED Q T + NF F A++ +F+ T E W
Sbjct: 1727 D----EDEF---------QITEHN---------------NFRTFFQALMLLFRSATGEAW 1758
Query: 367 TDVLYW-------------MNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 409
+++ + G E + YFVS + SF +LNL + V+ F
Sbjct: 1759 HNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
>gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo
sapiens]
Length = 2506
Score = 765 bits (1975), Expect = 0.0
Identities = 395/825 (47%), Positives = 550/825 (66%), Gaps = 56/825 (6%)
Query: 820 PCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGC 879
P +P EEE++EEE++ GP+P +P S+ FILS TNP+R C
Sbjct: 1191 PDPLPKKEEEKKEEEEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLC 1236
Query: 880 HKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMT 939
H ++N F IL+ I +SS ALAAEDP++ ++ RN +L YFDY FT +FT E+++KM
Sbjct: 1237 HYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMI 1296
Query: 940 TFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSA----ISVVKILRVLRVLRPLRAI 995
G LH+GA+ R+ +N+LD +VV +LV+F ++ I+ +K LRVLRVLRPL+ I
Sbjct: 1297 DLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTI 1356
Query: 996 NRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEEC 1055
R LK V CV +++ + NI+IV L F+FA + VQLFKGKF+ CTDE+K ++C
Sbjct: 1357 KRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC 1416
Query: 1056 RGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNG 1115
RG ++LY+ +V + R+R W+ +F++DNVL A++ LFTVST EGWP +L ++D+
Sbjct: 1417 RGKYLLYEKNEVKA---RDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1473
Query: 1116 ENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQC 1175
EN GP +R+E+SIF+++Y ++ FF +NIFV +I+TFQEQG+K + L+KN+R C
Sbjct: 1474 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERAC 1533
Query: 1176 VEYALKARPLRRYIPKNP--YQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMF 1233
+++A+ A+PL R++P+N +QY+ W V S PFEY + +I LNT+ L M+ Y S +
Sbjct: 1534 IDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAY 1593
Query: 1234 NDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTE 1293
+A+ + N+VFT +F++E VLKV+AF YF DAWN FD + V+GSI D+ ++E
Sbjct: 1594 ENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEF---- 1649
Query: 1294 SENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYV 1353
GN N I+++F RLFR RL+KLL +G IR LLWTF++SF+ALPYV
Sbjct: 1650 -----------GN----NFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1694
Query: 1354 ALLIAMLFFIYAVIGMQMFGKVAM--------RDNNQINRNNNFQTFPQAVLLLFRCATG 1405
LLIAMLFFIYA+IGMQ+FG + + D QI +NNF+TF QA++LLFR ATG
Sbjct: 1695 CLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATG 1754
Query: 1406 EAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMD 1465
EAW IML+CL GK CD S E CG+ FA YF+SF LC+FL++NLFVAVIMD
Sbjct: 1755 EAWHNIMLSCLSGKPCDKNSGILTRE---CGNEFAYFYFVSFIFLCSFLMLNLFVAVIMD 1811
Query: 1466 NFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHR 1525
NF+YLTRD SILGPHHLDE+ R+W+EYDP A GR+ +LD+ +LR + PPLG GK CP R
Sbjct: 1812 NFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMSPPLGLGKKCPAR 1871
Query: 1526 VACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE---GNLEQANEELRAVIKKIWK 1582
VA KRL+ M++P+ D TV FN+TL AL+RTAL IK + +Q + ELR + IW
Sbjct: 1872 VAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWP 1931
Query: 1583 KTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGL 1627
S K LD +V P ++TVGK YA +I +Y+R+ K +K Q +
Sbjct: 1932 NLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAM 1976
Score = 654 bits (1687), Expect = 0.0
Identities = 354/723 (48%), Positives = 470/723 (65%), Gaps = 38/723 (5%)
Query: 104 RALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEK 163
R+LF S +N +R+ I EW PF+ IL I ANC+ LA+ P+DD + L+
Sbjct: 76 RSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDD 135
Query: 164 VEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEG 223
E F+ IF E +KIIA G H +Y+RNGWN++DFV+V+ G+ + + +
Sbjct: 136 TEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------- 188
Query: 224 GNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 283
FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAM+PLL I LL+ F I+
Sbjct: 189 ----------FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAIL 238
Query: 284 IYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGG 343
I+AIIGLE ++GK H TCF +D + E PAPC R C NGT+C+ W GPN G
Sbjct: 239 IFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCP-NGTKCQPYWEGPNNG 297
Query: 344 ITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLG 403
IT FDN FA+LTVFQCITMEGWTD+LY NDA G W+YF+ L+I GSFF+LNLVLG
Sbjct: 298 ITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLG 357
Query: 404 VLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEE---- 459
VLSGEF+KERE+ + R F KLR +QQ+E +L GY++WI++AE++ +E GE+
Sbjct: 358 VLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPF 417
Query: 460 -GKRNTSMPTSETESVNTENVSGEGENRGCCGS--LCQAISKSKL--SRRWRRWNRFNRR 514
R T++ S+T+ +N E + + GS +I +KL S + + R R
Sbjct: 418 DALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRF 477
Query: 515 RCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKM 574
R VK+ FYW V+ LV LNTL ++ HYNQP+WL+ A + L LF EM +KM
Sbjct: 478 YIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKM 537
Query: 575 YSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWT 634
Y LG + YF S FN FDC V+ G I E I ++ + GISV R +RLLRIFKVT++W
Sbjct: 538 YGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWA 597
Query: 635 SLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQA 694
SL NLV SLLNSMKSI SLL LLFLFI++F+LLGMQLFGG+FNFDE T + FD FP A
Sbjct: 598 SLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDE-GTPPTNFDTFPAA 656
Query: 695 LLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDN 754
++TVFQILTGEDWN VMYDGI + GG GM+ IYFI+L + GNY LLNVFLAIAVDN
Sbjct: 657 IMTVFQILTGEDWNEVMYDGIKSQGG-VQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDN 715
Query: 755 LADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDED 814
LA+A+ L T ++E EE +K+A +++ E EV+ ++ ++ + + +E+ ++
Sbjct: 716 LANAQEL-TKDEQEEEEAANQKLALQKAKE-----VAEVSPLSAANMSIAV---KEQQKN 766
Query: 815 KDP 817
+ P
Sbjct: 767 QKP 769
Score = 217 bits (552), Expect = 1e-55
Identities = 180/719 (25%), Positives = 329/719 (45%), Gaps = 121/719 (16%)
Query: 67 QTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWK 126
Q + P P+ + K+++ + + P ++F LS NP+RR C I+ +
Sbjct: 1184 QVNKNANPDPLPKKEEEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLR 1243
Query: 127 PFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLL 186
F++ IL+ I + +ALA P + N+ L +Y F +FT E +K+I GL+
Sbjct: 1244 YFEMCILMVIAMSSIALAAEDPVQPNAPR--NNVLRYFDYVFTGVFTFEMVIKMIDLGLV 1301
Query: 187 LHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFD---VKALRAFR 243
LH AY R+ WN+LDF++V L + +G S G D +K+LR R
Sbjct: 1302 LHQGAYFRDLWNILDFIVVSGALVAFAF-------------TGNSKGKDINTIKSLRVLR 1348
Query: 244 VLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFF 303
VLRPL+ + +P L+ V + ++ ++ + +I ++ + + I+A++ ++LF GK FF
Sbjct: 1349 VLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGK-----FF 1403
Query: 304 ADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITM 363
+D ++E C G+ E ++ ++DN +A+LT+F T
Sbjct: 1404 HCTD-ESKEFEKDC----RGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTG 1458
Query: 364 EGWTDVLYWMNDA----------MGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKER 413
EGW VL DA E+ Y V V+F FFV N+ + ++ F ++
Sbjct: 1459 EGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFV-NIFVALIIITFQEQ- 1516
Query: 414 EKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETES 473
GD K+ E+ LE++ + +D+ A+
Sbjct: 1517 ------GD--KMMEEYSLEKNERACIDFAISAK--------------------------- 1541
Query: 474 VNTENVSGEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLV 533
L + + ++K S ++R W V S F + ++ ++
Sbjct: 1542 -----------------PLTRHMPQNKQSFQYRMWQ---------FVVSPPFEYTIMAMI 1575
Query: 534 FLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCF 593
LNT+ + + Y + N V +LF+ E ++K+ + G+ YF +N FD
Sbjct: 1576 ALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFV 1635
Query: 594 VVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASL 653
V G IT+ ++ E + + +S R R R+ K+ R ++ L+ + + S K++ +
Sbjct: 1636 TVLGSITDILVTEFG-NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1694
Query: 654 LLLLFLFIIIFSLLGMQLFGG--------KFNFDETQ-TKRSTFDNFPQALLTVFQILTG 704
LL+ + I++++GMQ+FG + DE Q T+ + F F QAL+ +F+ TG
Sbjct: 1695 CLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATG 1754
Query: 705 EDWNAVMYDGIMAYGGPSSSGMI--------VCIYFI-ILFICGNYILLNVFLAIAVDN 754
E W+ +M + +SG++ YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 1755 EAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1812
Score = 139 bits (350), Expect = 3e-32
Identities = 177/786 (22%), Positives = 321/786 (40%), Gaps = 168/786 (21%)
Query: 479 VSGEGENRGCCGSL------CQAISKSKLSRRWRRWNRFN----RRRC------------ 516
V G G RG GS Q + K +++R R +N R+ C
Sbjct: 24 VVGSGGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSE 83
Query: 517 ----RAAVKSVT----FYWLVIVLVFLNTLTISSEHYNQPDWLTQIQ---DIANKVLLAL 565
R K +T F ++++ + N + ++ E + D T + D + +
Sbjct: 84 DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 143
Query: 566 FTCEMLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCV 621
F E +K+ +LG +Y + +N D VV GI T+ E ++ + R V
Sbjct: 144 FCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT------LRAV 197
Query: 622 RLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFN---F 678
R+LR K+ SL ++ S++ +M + + LLLF I+IF+++G++ + GKF+ F
Sbjct: 198 RVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF 257
Query: 679 DE--------------TQTKRST--------------------FDNFPQALLTVFQILTG 704
+E T+ T FDN A+LTVFQ +T
Sbjct: 258 EEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITM 317
Query: 705 EDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTA 764
E W ++Y+ A G + +YFI L I G++ +LN+ L + A
Sbjct: 318 EGWTDLLYNSNDASGNTWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEFAK------- 365
Query: 765 QKEEAEEKER-KKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPC-- 821
++E E + K+ R++ +E + N E I+ ++ + +D + E + P+
Sbjct: 366 ERERVENRRAFLKLRRQQQIERELNGYME--WISKAEEVILAED-ETDGEQRHPFDALRR 422
Query: 822 --------DVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTN 873
D+ EE E++ D V + I + E S FF K
Sbjct: 423 TTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKL--------ENSTFFH-KKER 473
Query: 874 PIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVE 933
+R +++ F +L + L++ +A + + L Y ++ F +F E
Sbjct: 474 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH-YNQPEWLSDFLYYAEFIFLGLFMSE 532
Query: 934 ILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSL--VSFGIQSSAISV-VKILRVLRVLR 990
+ +KM G + + FN D V+ S+ V + + S + +LR LR+LR
Sbjct: 533 MFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLR 588
Query: 991 PLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKS 1050
+ L+++V + ++++I +++ + L +FA +G+QLF G+F
Sbjct: 589 IFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF--------- 639
Query: 1051 NPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKA 1110
+ D +P NFD +A+M +F + T E W ++Y
Sbjct: 640 -------------NFDEGTPPT----------NFDTFPAAIMTVFQILTGEDWNEVMYDG 676
Query: 1111 IDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVI--------VTFQEQGEKE 1162
I S G G + SI+FI+ + + ++N+F+ + +T EQ E+E
Sbjct: 677 IKSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEE 731
Query: 1163 YKNCEL 1168
N +L
Sbjct: 732 AANQKL 737
Score = 118 bits (295), Expect = 7e-26
Identities = 78/296 (26%), Positives = 137/296 (46%), Gaps = 44/296 (14%)
Query: 1181 KARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDIL 1240
K R +R YI + +V + F + + L+ LNTLC+A+ HY Q + +D +
Sbjct: 471 KERRMRFYIRR---------MVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 521
Query: 1241 NMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVP 1300
+F G+F EM +K+ + YF ++N FD ++IGSI +V + P S
Sbjct: 522 EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTS------ 575
Query: 1301 TATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML 1360
I+ R R++R+ K+ +R L+ + + S +++ + L+ +
Sbjct: 576 ------------FGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLF 623
Query: 1361 FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL 1420
++A++GMQ+FG D NF TFP A++ +F+ TGE W E+M
Sbjct: 624 IVVFALLGMQLFGGQFNFDEG--TPPTNFDTFPAAIMTVFQILTGEDWNEVMY------- 674
Query: 1421 CDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1473
D + G +YFI + + ++N+F+A+ +DN LT+D
Sbjct: 675 -----DGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 725
Score = 103 bits (257), Expect = 2e-21
Identities = 91/338 (26%), Positives = 158/338 (46%), Gaps = 47/338 (13%)
Query: 865 AFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAED--PIRSHSFRNTILGYF 922
+ F+ S+ N +R K+ F +IL I+ + LA E P + + L
Sbjct: 77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
Query: 923 DYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV--GVSLVSFGIQSSAISVV 980
+ F IF E +K+ G HKG++ RN +N++D +VV G+ L + G + +
Sbjct: 137 EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGI-LATVGTEFD----L 191
Query: 981 KILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGK 1040
+ LR +RVLRPL+ ++ L+ V++ + A+ + I ++ +FA IG++ + GK
Sbjct: 192 RTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGK 251
Query: 1041 FY-RCTDEAKSNPEECRGLFILYKDGDVDSPVVRER-------------IWQ---NSDFN 1083
F+ C +E + + G+ +P E W+ N
Sbjct: 252 FHTTCFEEGTDDIQ-----------GESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQ 300
Query: 1084 FDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFM 1143
FDN+L A++ +F T EGW LLY + D++G +Y FI III +FFM
Sbjct: 301 FDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLY---------FIPLIIIGSFFM 351
Query: 1144 MNIFVGFVIVTFQEQGEK-EYKNCELDKNQRQCVEYAL 1180
+N+ +G + F ++ E+ E + L ++Q +E L
Sbjct: 352 LNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIEREL 389
Score = 80.9 bits (198), Expect = 1e-14
Identities = 74/296 (25%), Positives = 131/296 (44%), Gaps = 61/296 (20%)
Query: 127 PFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLL 186
PF+ I+ I N + L + S + + L F +F++E LK++A+G+L
Sbjct: 1566 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1622
Query: 187 LHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLR 246
Y R+ WN+ DFV V+ + +++ TE GN+ ++ LR FR R
Sbjct: 1623 ----NYFRDAWNIFDFVTVLGSITDILV------TEFGNNF------INLSFLRLFRAAR 1666
Query: 247 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADS 306
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F G + DS
Sbjct: 1667 LIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-GNIGIDVEDEDS 1725
Query: 307 DIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGW 366
D ED Q T + NF F A++ +F+ T E W
Sbjct: 1726 D----EDEF---------QITEHN---------------NFRTFFQALMLLFRSATGEAW 1757
Query: 367 TDVLYW-------------MNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 409
+++ + G E + YFVS + SF +LNL + V+ F
Sbjct: 1758 HNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1813
Score = 69.7 bits (169), Expect = 3e-11
Identities = 67/308 (21%), Positives = 120/308 (38%), Gaps = 89/308 (28%)
Query: 1206 PFEYMMFVLIMLNTLCLAMQHY---EQSKMFNDAMDILNMVFTGVFTVEMVLKVIA---- 1258
PFEYM+ I+ N + LA++ + + ++ +D F G+F E +K+IA
Sbjct: 99 PFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFA 158
Query: 1259 FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFF 1318
F Y + WN D ++V+ I+ +E D +
Sbjct: 159 FHKGSYLRNGWNVMDFVVVLTGILATVGTEFD------------------------LRTL 194
Query: 1319 RLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF-GKVAM 1377
R RV+R +KL+S ++ +L + +K+ L + LL+ I+A+IG++ + GK
Sbjct: 195 RAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHT 254
Query: 1378 R--------------------------------------DNNQINRNNNFQTFPQAVLLL 1399
NN I + F AVL +
Sbjct: 255 TCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQ---FDNILFAVLTV 311
Query: 1400 FRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLF 1459
F+C T E W +++ YN + G+ + +YFI ++ +F ++NL
Sbjct: 312 FQCITMEGWTDLL--------------YNSND--ASGNTWNWLYFIPLIIIGSFFMLNLV 355
Query: 1460 VAVIMDNF 1467
+ V+ F
Sbjct: 356 LGVLSGEF 363
>gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B
subunit [Homo sapiens]
Length = 2339
Score = 761 bits (1965), Expect = 0.0
Identities = 466/1171 (39%), Positives = 646/1171 (55%), Gaps = 141/1171 (12%)
Query: 822 DVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHK 881
D+ E ++E E + + +GPRP I P S+ F LS TN +R CH
Sbjct: 1100 DLESQAEGKKEVEADDVMRSGPRP-----------IVPY---SSMFCLSPTNLLRRFCHY 1145
Query: 882 LINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTF 941
++ F +ILV I LSS ALAAEDP+R+ S RN L Y DY FT +FT E+++KM
Sbjct: 1146 IVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDL 1205
Query: 942 GAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSA---ISVVKILRVLRVLRPLRAINRA 998
G LH GA+ R+ +N+LD +VV +LV+F S I+ +K LRVLRVLRPL+ I R
Sbjct: 1206 GLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRL 1265
Query: 999 KGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGL 1058
LK V CV +++ + NI+IV L F+FA I VQLFKGKF+ CTDE+K +CRG
Sbjct: 1266 PKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQ 1325
Query: 1059 FILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENI 1118
++ Y+ +V++ + R W+ DF++DNVL A++ LFTVST EGWP +L ++D+ E
Sbjct: 1326 YLDYEKEEVEA---QPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQ 1382
Query: 1119 GPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEY 1178
GP +R+E+SIF+++Y ++ FF +NIFV +I+TFQEQG+K C L+KN+R C+++
Sbjct: 1383 GPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDF 1442
Query: 1179 ALKARPLRRYIPKN--PYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDA 1236
A+ A+PL RY+P+N +QYK W V S PFEY + +I LNT+ L M+ Y+ +
Sbjct: 1443 AISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELM 1502
Query: 1237 MDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESEN 1296
+ LN+VFT +F++E VLK+IAF YF DAWN FD + V+GSI D+ ++E
Sbjct: 1503 LKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI------- 1555
Query: 1297 VPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALL 1356
+E +N I+++F RLFR RL+KLL +G IR LLWTF++SF+ALPYV LL
Sbjct: 1556 ----------AETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLL 1605
Query: 1357 IAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACL 1416
IAMLFFIYA+IGMQ+FG +A+ D+ INR+NNF+TF QA++LLFR ATGEAW EIML+CL
Sbjct: 1606 IAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCL 1665
Query: 1417 PGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSI 1476
+ CD +++ CGS+FA YF+SF LC+FL++NLFVAVIMDNF+YLTRD SI
Sbjct: 1666 SNQACDEQANAT-----ECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSI 1720
Query: 1477 LGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNM 1536
LGPHHLDEF R+W+EYDP A GRI + D+ +L+ + PPLG GK CP RVA KRLV MNM
Sbjct: 1721 LGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNM 1780
Query: 1537 PL-NSDGTVMFNATLFALVRTALKIK---TEGNLEQANEELRAVIKKIWKKTSMKLLDQV 1592
P+ N D TV F +TL AL+RTAL+IK Q + ELR I +W K LD +
Sbjct: 1781 PISNEDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLL 1840
Query: 1593 VPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGP 1652
VPP DE+TVGK YA +I D++++ K ++Q +Q L +GP
Sbjct: 1841 VPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQ--------------MQQAPGGLSQMGP 1886
Query: 1653 -EIRRAISCDLQDDEPEETK------REEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTN 1705
+ + L+ +P + R++ GA+ N + + T
Sbjct: 1887 VSLFHPLKATLEQTQPAVLRGARVFLRQKSSTSLSNGGAI----QNQESGIKESVSWGTQ 1942
Query: 1706 TTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGK--QVPTSTNANLNNANM 1763
T H RP + TE P+ +V + G + + A+M
Sbjct: 1943 RTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQMQSITRRGPDGEPQPGLESQGRAASM 2002
Query: 1764 SKAAHGKRP---------SIGNLEHVSENGHHSSHKHDREPQRRSSVKRTRYYETYIRSD 1814
+ A +P SI L H S DR P ++S ++ + R D
Sbjct: 2003 PRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQAS-SHHHHHRCHRRRD 2061
Query: 1815 SGDEQL---------------------------PTICREDPEIHGYFRDPHCLGEQEYFS 1847
L PT CR + E QE
Sbjct: 2062 RKQRSLEKGPSLSADMDGAPSSAVGPGLPPGEGPTGCRRERE-----------RRQERGR 2110
Query: 1848 SEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPR-GYH------------HPQGFLEDD 1894
S+E + SS + +Q + R+ GR +P H HPQG +
Sbjct: 2111 SQERRQPSSSSS-EKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQEPGPHPQGSGSVN 2169
Query: 1895 DSPVCYDSRRSP----RRRLLPPTPASHRRS 1921
SP+ S S RR LP TP + R S
Sbjct: 2170 GSPLLSTSGASTPGRGGRRQLPQTPLTPRPS 2200
Score = 625 bits (1612), Expect = e-178
Identities = 348/692 (50%), Positives = 448/692 (64%), Gaps = 35/692 (5%)
Query: 104 RALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEK 163
R+LF S +N +R+ I EW PF+ IL I ANC+ LA+ P+ D + L+
Sbjct: 73 RSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDD 132
Query: 164 VEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEG 223
E F+ IF E +KIIA G + H +Y+RNGWN++DFV+V+ G+ + T G
Sbjct: 133 TEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---------TAG 183
Query: 224 GNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 283
+ FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAMVPLL I LL+ F I+
Sbjct: 184 TD--------FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIL 235
Query: 284 IYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGG 343
++AIIGLE ++GK HK CF +D D PC R C + TECR W GPN G
Sbjct: 236 MFAIIGLEFYMGKFHKACFPNSTDAEPVGD-FPCGKEAPARLCEGD-TECREYWPGPNFG 293
Query: 344 ITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLG 403
ITNFDN FA+LTVFQCITMEGWTD+LY NDA G W+YF+ L+I GSFF+LNLVLG
Sbjct: 294 ITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLG 353
Query: 404 VLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRN 463
VLSGEF+KERE+ + R F KLR +QQ+E +L GYL+WI +AE++ E+ EE
Sbjct: 354 VLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPL 413
Query: 464 TSMPTSETESVNTENVSGE-GENRGCCGSLCQAIS----------KSKLSRRWRRWNRFN 512
+ + T+ + + E GE+R LC S K++ S +RR +
Sbjct: 414 DVLKRAATKKSRNDLIHAEEGEDR--FADLCAVGSPFARASLKSGKTESSSYFRRKEKMF 471
Query: 513 RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLV 572
R R VK+ +FYW+V+ +V LNTL ++ HYNQP LT A V L LF EM +
Sbjct: 472 RFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSL 531
Query: 573 KMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRH 632
KMY LG ++YF S FN FD V+ G + E + ++ S GISV R +RLLRIFKVT++
Sbjct: 532 KMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKY 591
Query: 633 WTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFP 692
W+SL NLV SLLNSMKSI SLL LLFLFI++F+LLGMQLFGG+FNF + +T + FD FP
Sbjct: 592 WSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQD-ETPTTNFDTFP 650
Query: 693 QALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAV 752
A+LTVFQILTGEDWNAVMY GI + GG S GM YFI+L + GNY LLNVFLAIAV
Sbjct: 651 AAILTVFQILTGEDWNAVMYHGIESQGG-VSKGMFSSFYFIVLTLFGNYTLLNVFLAIAV 709
Query: 753 DNLADAESLNTAQKEEAEEKERKKIARKESLE 784
DNLA+A+ L T +EE EE +K+A +++ E
Sbjct: 710 DNLANAQEL-TKDEEEMEEAANQKLALQKAKE 740
Score = 221 bits (562), Expect = 8e-57
Identities = 180/706 (25%), Positives = 325/706 (46%), Gaps = 106/706 (15%)
Query: 68 TMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKP 127
T+ S + S ++ K++ A + P ++FCLS N +RR C IV +
Sbjct: 1092 TVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRY 1151
Query: 128 FDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLL 187
F++ IL+ I + +ALA P D N+ L+ ++Y F +FT E +K+I GLLL
Sbjct: 1152 FEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYLDYIFTGVFTFEMVIKMIDLGLLL 1209
Query: 188 HPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRP 247
HP AY R+ WN+LDF++V L + + S GK +K+LR RVLRP
Sbjct: 1210 HPGAYFRDLWNILDFIVVSGALVAFAF----------SGSKGKDIN-TIKSLRVLRVLRP 1258
Query: 248 LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSD 307
L+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK + D
Sbjct: 1259 LKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF---YCTDES 1315
Query: 308 IVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWT 367
E D + A + + ++DN +A+LT+F T EGW
Sbjct: 1316 KELERDCRGQYLDYEKEEVEAQPRQWKK-------YDFHYDNVLWALLTLFTVSTGEGWP 1368
Query: 368 DVLYWMNDA----------MGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAK 417
VL DA EL Y V V+F FFV N+ + ++ F ++
Sbjct: 1369 MVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFV-NIFVALIIITFQEQ----- 1422
Query: 418 ARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTE 477
GD K+ + LE++ + +D+ A+
Sbjct: 1423 --GD--KVMSECSLEKNERACIDFAISAK------------------------------- 1447
Query: 478 NVSGEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNT 537
L + + +++ S +++ W V S F + ++ ++ LNT
Sbjct: 1448 -------------PLTRYMPQNRQSFQYKTW---------TFVVSPPFEYFIMAMIALNT 1485
Query: 538 LTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCG 597
+ + + Y+ P + N V ++F+ E ++K+ + G+ YF +N FD V G
Sbjct: 1486 VVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLG 1545
Query: 598 GITETILVEL-EIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLL 656
IT+ ++ E+ E + + +S R R R+ K+ R ++ L+ + + S K++ + LL
Sbjct: 1546 SITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLL 1605
Query: 657 LFLFIIIFSLLGMQLFGGKFNFDETQTKR-STFDNFPQALLTVFQILTGEDWNAVMYDGI 715
+ + I++++GMQ+FG D+T R + F F QAL+ +F+ TGE W+ +M +
Sbjct: 1606 IAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCL 1665
Query: 716 MAYGGPSSSGMIVC------IYFI-ILFICGNYILLNVFLAIAVDN 754
+ C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 1666 SNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
Score = 132 bits (333), Expect = 3e-30
Identities = 151/709 (21%), Positives = 299/709 (42%), Gaps = 121/709 (17%)
Query: 525 FYWLVIVLVFLNTLTISSEHYNQPDW----LTQIQDIANKVLLALFTCEMLVKMYSLGLQ 580
F ++++ + N + ++ E + PD +++ D + +F E +K+ +LG
Sbjct: 97 FEYMILATIIANCIVLALEQH-LPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFV 155
Query: 581 ----AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSL 636
+Y + +N D VV GI T + ++ + R VR+LR K+ SL
Sbjct: 156 FHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRT------LRAVRVLRPLKLVSGIPSL 209
Query: 637 SNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNF------------------ 678
++ S++ +M + + LLLF I++F+++G++ + GKF+
Sbjct: 210 QVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCG 269
Query: 679 ---------DETQTKR---------STFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGG 720
+T+ + + FDN A+LTVFQ +T E W ++Y+ A G
Sbjct: 270 KEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGN 329
Query: 721 PSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKER-KKIAR 779
+ +YFI L I G++ +LN+ L + A ++E E + K+ R
Sbjct: 330 TWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEFAK-------ERERVENRRAFLKLRR 377
Query: 780 KESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEV 839
++ +E + N E I ++ + EED + + P DV ++ D
Sbjct: 378 QQQIERELNGYLE--WIFKAEEVMLA----EEDRNAEEKSPLDVLKRAATKKSRNDLIHA 431
Query: 840 PAGP-RPRRISELNMKEKIAPIPEG---SAFFILSKTNPIRVGCHKLINHHIFTNLILVF 895
G R + + A + G S+ + K R +++ F ++L
Sbjct: 432 EEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCV 491
Query: 896 IMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYF 955
+ L++ +A + T+ + ++ F +F E+ LKM G ++ R+ F
Sbjct: 492 VALNTLCVAMVHYNQPRRLTTTLY-FAEFVFLGLFLTEMSLKMYGLGP----RSYFRSSF 546
Query: 956 NLLDM-LVVG--VSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAI 1012
N D ++VG +V I+ + + +LR LR+LR + L+++V + ++
Sbjct: 547 NCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSM 606
Query: 1013 RTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVV 1072
++I +++ + L +FA +G+QLF G+F DE +
Sbjct: 607 KSIISLLFLLFLFIVVFALLGMQLFGGQF-NFQDETPTT--------------------- 644
Query: 1073 RERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFF 1132
NFD +A++ +F + T E W A++Y I+S G +++ S +F
Sbjct: 645 ----------NFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFS-----SFYF 689
Query: 1133 IIYIIIVAFFMMNIFVGFVIVTFQEQGE--KEYKNCELDKNQRQCVEYA 1179
I+ + + ++N+F+ + E K+ + E NQ+ ++ A
Sbjct: 690 IVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKA 738
Score = 122 bits (306), Expect = 4e-27
Identities = 75/292 (25%), Positives = 140/292 (47%), Gaps = 39/292 (13%)
Query: 1188 YIPKNPYQYKFWY--VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFT 1245
Y + ++F+ +V + F +++ ++ LNTLC+AM HY Q + + VF
Sbjct: 463 YFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFL 522
Query: 1246 GVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPG 1305
G+F EM LK+ P+ YF ++N FD +++GS+ +V + P S
Sbjct: 523 GLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSS----------- 571
Query: 1306 NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYA 1365
I+ R R++R+ K+ +R L+ + + S +++ + L+ + ++A
Sbjct: 572 -------FGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFA 624
Query: 1366 VIGMQMF-GKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPE 1424
++GMQ+F G+ +D NF TFP A+L +F+ TGE W +M + + +
Sbjct: 625 LLGMQLFGGQFNFQDETP---TTNFDTFPAAILTVFQILTGEDWNAVMYHGI-----ESQ 676
Query: 1425 SDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1473
+ G F+ YFI + + ++N+F+A+ +DN LT+D
Sbjct: 677 GGVSKG-------MFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
Score = 108 bits (271), Expect = 4e-23
Identities = 87/325 (26%), Positives = 154/325 (47%), Gaps = 22/325 (6%)
Query: 865 AFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAED--PIRSHSFRNTILGYF 922
+ F+ S+ N +R ++ F +IL I+ + LA E P + + L
Sbjct: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
Query: 923 DYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKI 982
+ F IF E +K+ G HKG++ RN +N++D +VV +++ + ++
Sbjct: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRT 190
Query: 983 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY 1042
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GKF+
Sbjct: 191 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFH 250
Query: 1043 RCTDEAKSNPEECRGLFILYKDGDV---DSPVVRERIWQNSDF---NFDNVLSAMMALFT 1096
+ ++ E G F K+ + W +F NFDN+L A++ +F
Sbjct: 251 KACFPNSTDAEPV-GDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQ 309
Query: 1097 VSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQ 1156
T EGW +LY D+ G +Y FI III +FFM+N+ +G + F
Sbjct: 310 CITMEGWTDILYNTNDAAGNTWNWLY---------FIPLIIIGSFFMLNLVLGVLSGEFA 360
Query: 1157 EQGEK-EYKNCELDKNQRQCVEYAL 1180
++ E+ E + L ++Q +E L
Sbjct: 361 KERERVENRRAFLKLRRQQQIEREL 385
Score = 82.0 bits (201), Expect = 6e-15
Identities = 71/294 (24%), Positives = 128/294 (43%), Gaps = 65/294 (22%)
Query: 127 PFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLL 186
PF+ FI+ I N V L + D L+ + F +F++E LKIIA+G+L
Sbjct: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
Query: 187 LHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLR 246
Y R+ WN+ DFV V+ + +++ ++ + N S LR FR R
Sbjct: 1529 ----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSF----------LRLFRAAR 1574
Query: 247 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADS 306
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1575 LIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------G 1622
Query: 307 DIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGW 366
+I ++D + + NF F A++ +F+ T E W
Sbjct: 1623 NIALDDDTSINRHN-------------------------NFRTFLQALMLLFRSATGEAW 1657
Query: 367 TDVLY--WMNDAM---------GFELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 409
+++ N A G + + YFVS + SF +LNL + V+ F
Sbjct: 1658 HEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
Score = 70.9 bits (172), Expect = 1e-11
Identities = 66/304 (21%), Positives = 122/304 (40%), Gaps = 82/304 (26%)
Query: 1206 PFEYMMFVLIMLNTLCLAMQHY---EQSKMFNDAMDILNMVFTGVFTVEMVLKVIA---- 1258
PFEYM+ I+ N + LA++ + ++ +D F G+F E +K+IA
Sbjct: 96 PFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFV 155
Query: 1259 FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFF 1318
F Y + WN D ++V+ I+ A ++ D +
Sbjct: 156 FHKGSYLRNGWNVMDFVVVLTGILATAGTDFD------------------------LRTL 191
Query: 1319 RLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF------ 1372
R RV+R +KL+S ++ +L + +K+ L + LL+ ++A+IG++ +
Sbjct: 192 RAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHK 251
Query: 1373 -----------------GKVA---MRDNNQINRN---------NNFQTFPQAVLLLFRCA 1403
GK A + + + R NF A+L +F+C
Sbjct: 252 ACFPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCI 311
Query: 1404 TGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVI 1463
T E W +I+ YN + G+ + +YFI ++ +F ++NL + V+
Sbjct: 312 TMEGWTDIL--------------YNTND--AAGNTWNWLYFIPLIIIGSFFMLNLVLGVL 355
Query: 1464 MDNF 1467
F
Sbjct: 356 SGEF 359
>gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E
subunit [Homo sapiens]
Length = 2270
Score = 727 bits (1877), Expect = 0.0
Identities = 380/816 (46%), Positives = 539/816 (66%), Gaps = 40/816 (4%)
Query: 824 PVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLI 883
P+ E E E+E+E E + +R + M +P S+ FI S TNPIR CH ++
Sbjct: 1098 PLKEAEIREDEEEVEKKKQKKEKRETGKAM------VPH-SSMFIFSTTNPIRRACHYIV 1150
Query: 884 NHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGA 943
N F IL+ I SS ALAAEDP+ ++S RN +L YFDY FT +FT E+++KM G
Sbjct: 1151 NLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGL 1210
Query: 944 FLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSA-------ISVVKILRVLRVLRPLRAIN 996
L G++ R+ +N+LD +VV +LV+F + ++ I +K LRVLRVLRPL+ I
Sbjct: 1211 ILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIK 1270
Query: 997 RAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECR 1056
R LK V CV +++ + NI+IV L F+FA I VQLFKGKF+ CTD +K +EC
Sbjct: 1271 RLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECI 1330
Query: 1057 GLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGE 1116
G ++ D + + V+ R W+ +F++DN++ A++ LFTVST EGWP +L ++D E
Sbjct: 1331 GNYV---DHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1387
Query: 1117 NIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCV 1176
+ GP ++R+E+SIF+++Y ++ FF +NIFV +I+TFQEQG+K + C L+KN+R C+
Sbjct: 1388 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERACI 1447
Query: 1177 EYALKARPLRRYIPKN--PYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFN 1234
++A+ A+PL RY+P+N +QY+ W+ V S FEY + +I LNT+ L M++Y +
Sbjct: 1448 DFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYE 1507
Query: 1235 DAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTES 1294
A+ LN+ FT VF++E VLKVIAF YF D WN FD + VIGSI ++ L T+S
Sbjct: 1508 LALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIIL-----TDS 1562
Query: 1295 ENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVA 1354
+ V ++ +++F +LFR RL+KLL +G IR LLWTF++SF+ALPYV
Sbjct: 1563 KLV-----------NTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVC 1611
Query: 1355 LLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLA 1414
LLIAMLFFIYA+IGMQ+FG + + + + INR+NNF++F +++LLFR ATGEAWQEIML+
Sbjct: 1612 LLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLS 1671
Query: 1415 CLPGKLCDPESDYNPG--EEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTR 1472
CL K C+P++ G E CG++ A VYF+SF C+FL++NLFVAVIMDNF+YLTR
Sbjct: 1672 CLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTR 1731
Query: 1473 DWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLV 1532
D SILGPHHLDEF R+W+EYD A GRI + ++ +L + PPLG GK CP +VA KRLV
Sbjct: 1732 DSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLV 1791
Query: 1533 AMNMPLNSDGTVMFNATLFALVRTALKIKTE---GNLEQANEELRAVIKKIWKKTSMKLL 1589
MNMP+ D TV F +TL AL+RTAL IK + +Q + EL+ IW S K+L
Sbjct: 1792 LMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKML 1851
Query: 1590 DQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQ 1625
D +VP ++TVGK YA +I DY+++ K +K++
Sbjct: 1852 DLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQR 1887
Score = 618 bits (1593), Expect = e-176
Identities = 362/775 (46%), Positives = 478/775 (61%), Gaps = 51/775 (6%)
Query: 33 PLSGEGPTSQPNSSKQTVL--SWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAK 90
P SG+G + Q + + T + S QAA +A+ A+TM+ P PV RQ
Sbjct: 12 PGSGDGDSDQSRNRQGTPVPASGQAAAYKQTKAQRARTMALYNPIPV-------RQNCFT 64
Query: 91 SKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFP 150
R+LF +N +R+ +++W PF+ IL I ANC+ LA+ P
Sbjct: 65 VN-----------RSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLP 113
Query: 151 EDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLF 210
EDD + LEK E F+ IF E +KI+A G + H +Y+RNGWN++DF++V+ G+
Sbjct: 114 EDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGIL 173
Query: 211 SVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVP 270
+ T T H D++ LRA RVLRPL+LVSG+PSLQ+VL SI+KAMVP
Sbjct: 174 A------TAGTHFNTH-------VDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVP 220
Query: 271 LLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPA-PCAFSGNGRQCTAN 329
LL I LL+ F I+++AIIGLE + GK+H+ CF +S I+ DP PC G C A
Sbjct: 221 LLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPCGVQG----CPA- 275
Query: 330 GTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSL 389
G EC+ W+GPN GIT FDN FA+LTVFQCITMEGWT VLY NDA+G W+YF+ L
Sbjct: 276 GYECKD-WIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPL 334
Query: 390 VIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDI- 448
+I GSFFVLNLVLGVLSGEF+KERE+ + R F KLR +QQ+E +L GY WI +AE++
Sbjct: 335 IIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVM 394
Query: 449 -DPENEEEGGE--EGKRNTSMPTSETESVNTENVSGEGENRGCCGS-LCQAISKSKLS-- 502
EN+ G E R ++ S TE++ ++ + G+ L +A KS
Sbjct: 395 LAEENKNAGTSALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDG 454
Query: 503 -RRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKV 561
+R R R R VKS FYW+V+ LV LNT ++ H+NQP WLT + A +
Sbjct: 455 VSYFRHKERLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFL 514
Query: 562 LLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCV 621
L LF EM +KMY +G + YF S FN FD V G I E + + GISV R +
Sbjct: 515 FLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRAL 574
Query: 622 RLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDET 681
RLLRIFK+T++W SL NLV SL++SMKSI SLL LLFLFI++F+LLGMQLFGG+FNF++
Sbjct: 575 RLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFND- 633
Query: 682 QTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNY 741
T + FD FP A++TVFQILTGEDWN VMY+GI + GG SSGM IYFI+L + GNY
Sbjct: 634 GTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGG-VSSGMWSAIYFIVLTLFGNY 692
Query: 742 ILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQI 796
LLNVFLAIAVDNLA+A+ L T ++E EE +K A +++ E + P + I
Sbjct: 693 TLLNVFLAIAVDNLANAQEL-TKDEQEEEEAFNQKHALQKAKEVSPMSAPNMPSI 746
Score = 213 bits (541), Expect = 2e-54
Identities = 173/704 (24%), Positives = 322/704 (45%), Gaps = 121/704 (17%)
Query: 82 QRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCV 141
++K+Q K +K+ P ++F S NPIRRAC IV + F++ ILL I A+ +
Sbjct: 1112 EKKKQ---KKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSI 1168
Query: 142 ALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLD 201
ALA P + N L +Y F +FT E +K+I GL+L +Y R+ WN+LD
Sbjct: 1169 ALAAEDPVLTNSER--NKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILD 1226
Query: 202 FVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVL 261
FV+V+ L + L +G + + +K+LR RVLRPL+ + +P L+ V
Sbjct: 1227 FVVVVGALVAFALANALGTNKGRDIKT-------IKSLRVLRVLRPLKTIKRLPKLKAVF 1279
Query: 262 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSG 321
+ ++ ++ + +I ++ + I+A+I ++LF GK FF +D + +
Sbjct: 1280 DCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGK-----FFYCTDSSKDTE-------- 1326
Query: 322 NGRQCTANGTECRSGWVGPNG-----GITNFDNFAFAMLTVFQCITMEGWTDVLYWMND- 375
++C N + + G ++DN +A+LT+F T EGW VL D
Sbjct: 1327 --KECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDV 1384
Query: 376 ---------AMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLR 426
+ E+ Y V V+F FFV N+ + ++ F ++ GD K+
Sbjct: 1385 TEEDRGPSRSNRMEMSIFYVVYFVVFPFFFV-NIFVALIIITFQEQ-------GD--KMM 1434
Query: 427 EKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVSGEGENR 486
E+ LE++ + +D+ A+
Sbjct: 1435 EECSLEKNERACIDFAISAK---------------------------------------- 1454
Query: 487 GCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYN 546
L + + +++ + ++R W+ V S +F + ++ ++ LNT+ + ++Y+
Sbjct: 1455 ----PLTRYMPQNRHTFQYRVWH---------FVVSPSFEYTIMAMIALNTVVLMMKYYS 1501
Query: 547 QPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVE 606
P N +F+ E ++K+ + G YF +N FD V G ITE IL +
Sbjct: 1502 APCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTD 1561
Query: 607 LEIMSPLG--ISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIF 664
++++ G +S + R R+ K+ R ++ L+ + + S K++ + LL+ + I+
Sbjct: 1562 SKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIY 1621
Query: 665 SLLGMQLFGG-KFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYG---- 719
+++GMQ+FG K + + + + F +F +L+ +F+ TGE W +M + G
Sbjct: 1622 AIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPD 1681
Query: 720 --GPSSSGM-------IVCIYFIILFICGNYILLNVFLAIAVDN 754
PS + +YF+ ++++LN+F+A+ +DN
Sbjct: 1682 TTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
Score = 189 bits (479), Expect = 3e-47
Identities = 171/699 (24%), Positives = 301/699 (43%), Gaps = 141/699 (20%)
Query: 865 AFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAED--PIRSHSFRNTILGYF 922
+ FI + N +R KLI+ F +IL I+ + LA E P + + L
Sbjct: 68 SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
Query: 923 DYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV--GVSLVSFGIQSSAISVV 980
+ F IF E +K+ G HKG++ RN +N++D +VV G+ L + G + +
Sbjct: 128 EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGI-LATAGTHFNTHVDL 186
Query: 981 KILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGK 1040
+ LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GK
Sbjct: 187 RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGK 246
Query: 1041 FYRCTDEAKSN-------PEEC--RGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAM 1091
+R S P C +G Y+ D P + FDN+L A+
Sbjct: 247 LHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGP-------NDGITQFDNILFAV 299
Query: 1092 MALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVG-- 1149
+ +F T EGW +LY D+ +G +N ++FI III +FF++N+ +G
Sbjct: 300 LTVFQCITMEGWTTVLYNTNDA----LGATWNW-----LYFIPLIIIGSFFVLNLVLGVL 350
Query: 1150 ----------------FVIVTFQEQGEKEYKNCEL------------------------- 1168
F+ + Q+Q E+E
Sbjct: 351 SGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVL 410
Query: 1169 ---------------DKNQRQCVEYALKARPLRRYIPKNP-------YQYK-------FW 1199
D + CV+ + PL R K+ +++K
Sbjct: 411 RRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIR 470
Query: 1200 YVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAF 1259
++V S F +++ L+ LNT C+A+ H+ Q + + +F G+F +EM LK+
Sbjct: 471 HMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGM 530
Query: 1260 KPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFR 1319
P+ YF ++N FD + +GSI +V + PG S I+ R
Sbjct: 531 GPRLYFHSSFNCFDFGVTVGSIFEVVWA-------------IFRPGTS-----FGISVLR 572
Query: 1320 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRD 1379
R++R+ K+ +R L+ + + S +++ + L+ + ++A++GMQ+FG +
Sbjct: 573 ALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG--GRFN 630
Query: 1380 NNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYN--PGEEYTCGS 1437
N + NF TFP A++ +F+ TGE W E+M YN +
Sbjct: 631 FNDGTPSANFDTFPAAIMTVFQILTGEDWNEVM--------------YNGIRSQGGVSSG 676
Query: 1438 NFAIVYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1473
++ +YFI + + ++N+F+A+ +DN LT+D
Sbjct: 677 MWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 715
Score = 131 bits (330), Expect = 6e-30
Identities = 157/736 (21%), Positives = 301/736 (40%), Gaps = 139/736 (18%)
Query: 513 RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKV---LLALFTCE 569
R+ + + F ++++ + N + ++ E + D T + K + +F E
Sbjct: 79 RKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFE 138
Query: 570 MLVKMYSLGL----QAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLR 625
+K+ +LG +Y + +N D VV GI T + + + R VR+LR
Sbjct: 139 AGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFN--THVDLRTLRAVRVLR 196
Query: 626 IFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFN-------- 677
K+ SL ++ S++ +M + + LLLF I++F+++G++ + GK +
Sbjct: 197 PLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNS 256
Query: 678 -----FDETQTKR--------------------STFDNFPQALLTVFQILTGEDWNAVMY 712
FD + FDN A+LTVFQ +T E W V+Y
Sbjct: 257 GILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLY 316
Query: 713 DGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEK 772
+ A G + +YFI L I G++ +LN+ L + A ++E E +
Sbjct: 317 NTNDALGATWN-----WLYFIPLIIIGSFFVLNLVLGVLSGEFAK-------ERERVENR 364
Query: 773 ER-KKIARKESLENKKN------NKPEVNQIANSDN-----------KVTIDDYREEDED 814
K+ R++ +E + N +K E +A + + TI R E
Sbjct: 365 RAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMT 424
Query: 815 KDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNP 874
+D DE V ++ ++K +G ++F K
Sbjct: 425 RD----------------SSDEHCVDISSVGTPLARASIKSAKV---DGVSYF-RHKERL 464
Query: 875 IRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEI 934
+R+ ++ +F ++L + L++A +A + +L Y ++ F +F +E+
Sbjct: 465 LRISIRHMVKSQVFYWIVLSLVALNTACVAIVHH-NQPQWLTHLLYYAEFLFLGLFLLEM 523
Query: 935 LLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSL--VSFGIQSSAISV-VKILRVLRVLRP 991
LKM G L + + FN D V S+ V + I S + +LR LR+LR
Sbjct: 524 SLKMYGMGPRL----YFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRI 579
Query: 992 LRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSN 1051
+ L+++V + ++++I +++ + L +FA +G+QLF G+F
Sbjct: 580 FKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFN--------- 630
Query: 1052 PEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAI 1111
+ DG + NFD +A+M +F + T E W ++Y I
Sbjct: 631 ----------FNDGTPSA-------------NFDTFPAAIMTVFQILTGEDWNEVMYNGI 667
Query: 1112 DSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGE--KEYKNCELD 1169
S G +++ +I+FI+ + + ++N+F+ + E K+ + E
Sbjct: 668 RSQGGVSSGMWS-----AIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEA 722
Query: 1170 KNQRQCVEYALKARPL 1185
NQ+ ++ A + P+
Sbjct: 723 FNQKHALQKAKEVSPM 738
Score = 87.0 bits (214), Expect = 2e-16
Identities = 66/267 (24%), Positives = 122/267 (45%), Gaps = 68/267 (25%)
Query: 161 LEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKE 220
L+ + AF ++F++E LK+IA+G L Y R+ WN+ DF+ VI + +IL
Sbjct: 1510 LKYLNIAFTMVFSLECVLKVIAFGFL----NYFRDTWNIFDFITVIGSITEIILT----- 1560
Query: 221 TEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLF 280
+ + GF++ L+ FR R ++L+ +++++L + +++ L ++ LL+
Sbjct: 1561 ----DSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAM 1616
Query: 281 VIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGP 340
+ IYAIIG+++F +I +E+ S R
Sbjct: 1617 LFFIYAIIGMQVF------------GNIKLDEE------SHINRH--------------- 1643
Query: 341 NGGITNFDNFAFAMLTVFQCITMEGWTDVLYWM------------------NDAMGFELP 382
NF +F +++ +F+ T E W +++ N+ G +L
Sbjct: 1644 ----NNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLA 1699
Query: 383 WVYFVSLVIFGSFFVLNLVLGVLSGEF 409
+VYFVS + F SF +LNL + V+ F
Sbjct: 1700 YVYFVSFIFFCSFLMLNLFVAVIMDNF 1726
>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
[Homo sapiens]
Length = 2005
Score = 420 bits (1080), Expect = e-117
Identities = 336/1164 (28%), Positives = 559/1164 (48%), Gaps = 196/1164 (16%)
Query: 529 VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFN 588
+ + + LNTL ++ EHY + + + + N V +FT EM +K+ ++ YF +N
Sbjct: 765 ITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWN 824
Query: 589 RFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMK 648
FD F+V + E L +E G+SV R RLLR+FK+ + W +L+ L+ + NS+
Sbjct: 825 IFDGFIVSLSLMELGLANVE-----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 879
Query: 649 SIASLLLLLFLFIIIFSLLGMQLFGGKFN------FDETQTKRSTFDNFPQALLTVFQIL 702
++ +L L+L + + IF+++GMQLFG + ++ + R +F + L VF++L
Sbjct: 880 ALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVL 939
Query: 703 TGEDWNAVMYDGIMAYGGPSSSGMIVCI-YFIILFICGNYILLNVFLAIAV-----DNLA 756
GE W M+D + +G +C+ F+++ + GN ++LN+FLA+ + DNLA
Sbjct: 940 CGE-WIETMWDCM------EVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLA 992
Query: 757 ---DAESLNTAQ-------------KEEAEEKERKKIARK----------ESLENKKNN- 789
D +N Q K + E +K RK E L NKK++
Sbjct: 993 ATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSC 1052
Query: 790 -------------------KPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVP--VGE- 827
+ I +S K +D+ +P VP VGE
Sbjct: 1053 ISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGES 1112
Query: 828 ----------------EEEEEE-----------------------EDEPEVPAGPRPRRI 848
EE +E+ E EPE P
Sbjct: 1113 DFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFT 1172
Query: 849 SELNMKEKIAPIP----EGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALA 904
+ K K I +G ++ L KT C+K++ H+ F I+ I+LSS ALA
Sbjct: 1173 EDCVRKFKCCQISIEEGKGKLWWNLRKT------CYKIVEHNWFETFIVFMILLSSGALA 1226
Query: 905 AED-PIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV 963
ED I T+L Y D FT IF +E+LLK +G + N + LD L+V
Sbjct: 1227 FEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGF----QVYFTNAWCWLDFLIV 1282
Query: 964 GVSLVSF---GIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMI 1020
VSLVS + S + +K LR LR LRPLRA++R +G++ VV + AI +I N+++
Sbjct: 1283 DVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLL 1342
Query: 1021 VTTLLQFMFACIGVQLFKGKFYRCTD---------EAKSNPEECRGLFILYKDGDVDSPV 1071
V + +F+ +GV LF GKFY C + +N EC+ L ++S
Sbjct: 1343 VCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKAL--------IESNQ 1394
Query: 1072 VRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIF 1131
W+N NFDNV ++L V+TF+GW ++Y A+DS + P Y + + ++
Sbjct: 1395 TAR--WKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLY 1452
Query: 1132 FIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEY-ALK-------AR 1183
F+I+II +FF +N+F+G +I F +Q +K++ ++ + Q Y A+K +
Sbjct: 1453 FVIFIIFGSFFTLNLFIGVIIDNFNQQ-KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1511
Query: 1184 PLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMV 1243
P+ R P N +Q + V F+ + +LI LN + + ++ +QS+ + + +N+V
Sbjct: 1512 PIPR--PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLV 1569
Query: 1244 FTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTAT 1303
F +FT E VLK+I+ + YF+ WN FD ++VI SI+ + L+E
Sbjct: 1570 FIVLFTGECVLKLISLR-YYYFTIGWNIFDFVVVILSIVGMFLAEL-------------- 1614
Query: 1304 PGNSEESNRISITFF---RLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML 1360
E +S T F RL R+ R+++L+ +GIRTLL+ + S AL + LL+ ++
Sbjct: 1615 ----IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV 1670
Query: 1361 FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPG-- 1418
FIYA+ GM F V + I+ NF+TF +++ LF+ T W ++ L
Sbjct: 1671 MFIYAIFGMSNFAYV--KREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGP 1728
Query: 1419 KLCDPESDYNPGEEY--TCGS-NFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1475
CDP+ D+ PG CG+ + I +F+S+ ++ +++N+++AVI++NF T + +
Sbjct: 1729 PDCDPDKDH-PGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESA 1787
Query: 1476 -ILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAM 1534
L + F +W ++DP+A I+ + + PPL K P++V +L+AM
Sbjct: 1788 EPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAK--PNKV---QLIAM 1842
Query: 1535 NMPLNSDGTVMFNATLFALVRTAL 1558
++P+ S + LFA + L
Sbjct: 1843 DLPMVSGDRIHCLDILFAFTKRVL 1866
Score = 147 bits (370), Expect = 1e-34
Identities = 107/376 (28%), Positives = 179/376 (47%), Gaps = 73/376 (19%)
Query: 105 ALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKV 164
AL+ L+ NPIR+ I I+ F++ I+ I NCV + + P P+ N V
Sbjct: 108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP-PDWTKN--------V 158
Query: 165 EYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGG 224
EY F I+T E+ +KI+A G L ++R+ WN LDF ++ +T+ G
Sbjct: 159 EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAY-------VTEFVNLG 211
Query: 225 NHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284
N V ALR FRVLR L+ +S +P L+ ++ ++I+++ L + +L +F + +
Sbjct: 212 N----------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV 261
Query: 285 YAIIGLELFIGKMHKTC----------------FFADS---------------------- 306
+A+IGL+LF+G + C FF +S
Sbjct: 262 FALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIE 321
Query: 307 ------DIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360
+ + D C S + QC G C PN G T+FD F++A L++F+
Sbjct: 322 DKSHFYFLEGQNDALLCGNSSDAGQC-PEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRL 380
Query: 361 ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG 420
+T + W + LY + + ++FV ++ GSF+++NL+L V++ + +E+ +A
Sbjct: 381 MTQDFWEN-LYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAY-EEQNQATLEE 438
Query: 421 DFQKLREKQQLEEDLK 436
QK E QQ+ E LK
Sbjct: 439 AEQKEAEFQQMLEQLK 454
Score = 137 bits (346), Expect = 9e-32
Identities = 98/328 (29%), Positives = 157/328 (47%), Gaps = 41/328 (12%)
Query: 115 IRRACISIVEWKPFDIFILLAIFANCVALA---IYIPFPEDDSNSTNHNLEKVEYAFLII 171
+R+ C IVE F+ FI+ I + ALA IYI + + LE + F I
Sbjct: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYI----EQRKTIKTMLEYADKVFTYI 1252
Query: 172 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231
F +E LK +AYG Y N W LDF+IV V L S+ L G
Sbjct: 1253 FILEMLLKWVAYGF----QVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGA------- 1301
Query: 232 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291
+K+LR R LRPLR +S ++VV+N+++ A+ ++++ L+ L +I++I+G+
Sbjct: 1302 ----IKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVN 1357
Query: 292 LFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTA-NGTECRSGWVGPNGGITNFDNF 350
LF GK + + ++ + N +C A + + W NFDN
Sbjct: 1358 LFAGKFYHCINYTTGEMF------DVSVVNNYSECKALIESNQTARWKNVK---VNFDNV 1408
Query: 351 AFAMLTVFQCITMEGWTDVLYWMNDAMGFELP---------WVYFVSLVIFGSFFVLNLV 401
L++ Q T +GW D++Y D+ EL ++YFV +IFGSFF LNL
Sbjct: 1409 GLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLF 1468
Query: 402 LGVLSGEFSKEREKAKARGDFQKLREKQ 429
+GV+ F+++++K + F +K+
Sbjct: 1469 IGVIIDNFNQQKKKFGGQDIFMTEEQKK 1496
Score = 120 bits (302), Expect = 1e-26
Identities = 78/273 (28%), Positives = 133/273 (48%), Gaps = 46/273 (16%)
Query: 1201 VVNSSPF-EYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAF 1259
+V PF + + + I+LNTL +AM+HY ++ F+ + + N+VFTG+FT EM LK+IA
Sbjct: 754 LVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAM 813
Query: 1260 KPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFR 1319
P YF + WN FD IV S++++ L+ + ++ R
Sbjct: 814 DPYYYFQEGWNIFDGFIVSLSLMELGLANVE-----------------------GLSVLR 850
Query: 1320 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGK----- 1374
FR++R+ KL + L+ S AL + L++A++ FI+AV+GMQ+FGK
Sbjct: 851 SFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKEC 910
Query: 1375 VAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYT 1434
V N+ + F + L++FR GE W E M C+
Sbjct: 911 VCKISNDCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCME----------------V 953
Query: 1435 CGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1467
G + F+ ++ +++NLF+A+++ +F
Sbjct: 954 AGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSF 986
Score = 102 bits (255), Expect = 3e-21
Identities = 101/434 (23%), Positives = 180/434 (41%), Gaps = 62/434 (14%)
Query: 398 LNLVLGVLSGEFSKER---EKAKARGDFQKLREKQQLEEDLKGY-LDWITQAEDIDPENE 453
L + + + GE E E+ + D ++ +EK +G +D AE PE E
Sbjct: 1101 LTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVE 1160
Query: 454 EEGGEEGKRNTSMPTSETESVNTENVSGEGENRGCCGSLCQAISKSKLSRRWRRWNRFNR 513
E + E E+ TE+ + + CQ + + W WN R
Sbjct: 1161 PE-----------ESLEPEACFTEDCVRKFK-------CCQISIEEGKGKLW--WNL--R 1198
Query: 514 RRCRAAVKSVTFYWLVIVLVFLNTLTISSE--HYNQPDWLTQIQDIANKVLLALFTCEML 571
+ C V+ F ++ ++ L++ ++ E + Q + + + A+KV +F EML
Sbjct: 1199 KTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEML 1258
Query: 572 VKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTR 631
+K + G Q YF + + D +V + L I R +R LR +
Sbjct: 1259 LKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALS 1318
Query: 632 HWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF--------------- 676
+ + +V +LL ++ SI ++LL+ +F +IFS++G+ LF GKF
Sbjct: 1319 RFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVS 1378
Query: 677 ---NFDE-------TQTKR-----STFDNFPQALLTVFQILTGEDWNAVMYDGI----MA 717
N+ E QT R FDN L++ Q+ T + W +MY + +
Sbjct: 1379 VVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVE 1438
Query: 718 YGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKI 777
+ + +YF+I I G++ LN+F+ + +DN + Q E+++K
Sbjct: 1439 LQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYY 1498
Query: 778 ARKESLENKKNNKP 791
+ L +KK KP
Sbjct: 1499 NAMKKLGSKKPQKP 1512
Score = 92.4 bits (228), Expect = 4e-18
Identities = 73/255 (28%), Positives = 123/255 (48%), Gaps = 20/255 (7%)
Query: 795 QIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEED-EPEVPAGPR----PRRIS 849
+IA K + ++ED++ P P D+ G+ D PE+ + P P I+
Sbjct: 28 RIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFIYGDIPPEMVSVPLEDLDPYYIN 87
Query: 850 E-----LNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALA 904
+ LN + I+ A +IL+ NPIR K++ H +F LI+ I+ + +
Sbjct: 88 KKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMT 147
Query: 905 AEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVG 964
+P + + +Y FT I+T E L+K+ G L F R+ +N LD V+
Sbjct: 148 MSNP---PDWTKNV----EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVIT 200
Query: 965 VSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTL 1024
+ V+ + +S LR RVLR L+ I+ GLK +V + +++ + ++MI+T
Sbjct: 201 FAYVTEFVNLGNVSA---LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVF 257
Query: 1025 LQFMFACIGVQLFKG 1039
+FA IG+QLF G
Sbjct: 258 CLSVFALIGLQLFMG 272
Score = 82.0 bits (201), Expect = 6e-15
Identities = 77/296 (26%), Positives = 133/296 (44%), Gaps = 61/296 (20%)
Query: 120 ISIVEWKPF-DIFILLAIFANCVALAI-YIPFPEDDSNSTNHNLEKVEYAFLIIFTVETF 177
+++V PF D+ I + I N + +A+ + P E S+ L F IFT E F
Sbjct: 752 VNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSV----LSVGNLVFTGIFTAEMF 807
Query: 178 LKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVK 237
LKIIA + P Y + GWN+ D IV + L + L + EG +
Sbjct: 808 LKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANV----EG------------LS 847
Query: 238 ALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKM 297
LR+FR+LR +L P+L +++ I ++ L ++ L++ ++ I+A++G++LF GK
Sbjct: 848 VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKS 906
Query: 298 HKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECR-SGWVGPNGGITNFDNFAFAMLT 356
+K C C S +C W + +F + L
Sbjct: 907 YKECV--------------CKIS----------NDCELPRW--------HMHDFFHSFLI 934
Query: 357 VFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKE 412
VF+ + E W + ++ + G + F+ +++ G+ VLNL L +L FS +
Sbjct: 935 VFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSD 989
Score = 78.6 bits (192), Expect = 6e-14
Identities = 80/394 (20%), Positives = 158/394 (40%), Gaps = 84/394 (21%)
Query: 80 LSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFAN 139
+++ +++ Y KK G+ +P N + V + FDI I++ I N
Sbjct: 1490 MTEEQKKYYNAMKKLGSKKPQKPIPRPA-----NKFQGMVFDFVTKQVFDISIMILICLN 1544
Query: 140 CVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNL 199
V + + +D S + L + F+++FT E LK+I+ Y GWN+
Sbjct: 1545 MVTMMVET---DDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYY-----YFTIGWNI 1596
Query: 200 LDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQV 259
DFV+VI+ + + L +L ++ + +R R+ R LRL+ G ++
Sbjct: 1597 FDFVVVILSIVGMFLAELIEKYFVSPTL--------FRVIRLARIGRILRLIKGAKGIRT 1648
Query: 260 VLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAF 319
+L +++ ++ L +I LL+ V+ IYAI G+ F + ++ ++
Sbjct: 1649 LLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA--------YVKREVGIDD------- 1693
Query: 320 SGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWM------ 373
+ NF+ F +M+ +FQ T GW +L +
Sbjct: 1694 ------------------------MFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPP 1729
Query: 374 --------------NDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFS---KEREKA 416
D + +FVS +I V+N+ + V+ FS +E +
Sbjct: 1730 DCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEP 1789
Query: 417 KARGDFQKLREK-QQLEEDLKGYLDWITQAEDID 449
+ DF+ E ++ + D ++++ ++ D
Sbjct: 1790 LSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFAD 1823
Score = 53.9 bits (128), Expect = 2e-06
Identities = 44/187 (23%), Positives = 84/187 (44%), Gaps = 34/187 (18%)
Query: 1190 PKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFT 1249
P NP + ++ S F ++ I+ N + + M + D + FTG++T
Sbjct: 114 PFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPP------DWTKNVEYTFTGIYT 167
Query: 1250 VEMVLKVIA----FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPG 1305
E ++K++A + + D WN D ++ + + TE N+ G
Sbjct: 168 FESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYV---------TEFVNL-------G 211
Query: 1306 NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYA 1365
N ++ R FRV+R +K +S G++T++ I+S + L V +L ++A
Sbjct: 212 N--------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 263
Query: 1366 VIGMQMF 1372
+IG+Q+F
Sbjct: 264 LIGLQLF 270
Score = 50.1 bits (118), Expect = 2e-05
Identities = 36/154 (23%), Positives = 70/154 (45%), Gaps = 16/154 (10%)
Query: 525 FYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ---- 580
F L++ + N + ++ N PDW ++ ++T E L+K+ + G
Sbjct: 131 FNMLIMCTILTNCVFMTMS--NPPDWTKNVE----YTFTGIYTFESLIKILARGFCLEDF 184
Query: 581 AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLV 640
+ +N D V+ T E ++ +S R R+LR K L +V
Sbjct: 185 TFLRDPWNWLDFTVI------TFAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIV 238
Query: 641 ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGG 674
+L+ S+K ++ +++L + +F+L+G+QLF G
Sbjct: 239 GALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 272
Score = 47.4 bits (111), Expect = 2e-04
Identities = 29/117 (24%), Positives = 59/117 (50%), Gaps = 9/117 (7%)
Query: 686 STFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLN 745
++FD F A L++F+++T + W + + A +G I+F+++ G++ L+N
Sbjct: 365 TSFDTFSWAFLSLFRLMTQDFWENLYQLTLRA------AGKTYMIFFVLVIFLGSFYLIN 418
Query: 746 VFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNK 802
+ LA+ E N A EEAE+KE + E L+ ++ A+++++
Sbjct: 419 LILAVVA---MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESR 472
Score = 37.0 bits (84), Expect = 0.21
Identities = 22/99 (22%), Positives = 47/99 (47%), Gaps = 10/99 (10%)
Query: 1083 NFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFF 1142
+FD A ++LF + T + W L + + G+ IFF++ I + +F+
Sbjct: 366 SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTY----------MIFFVLVIFLGSFY 415
Query: 1143 MMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALK 1181
++N+ + V + ++EQ + + E + + Q + LK
Sbjct: 416 LINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLK 454
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,787,904
Number of Sequences: 37866
Number of extensions: 3993116
Number of successful extensions: 27755
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 157
Number of HSP's successfully gapped in prelim test: 204
Number of HSP's that attempted gapping in prelim test: 19636
Number of HSP's gapped (non-prelim): 3173
length of query: 2161
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2043
effective length of database: 13,779,330
effective search space: 28151171190
effective search space used: 28151171190
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.