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Search of human proteins with 192807298
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|192807298 calcium channel, voltage-dependent, L type, alpha
1D subunit isoform c [Homo sapiens]
(2137 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|192807298 calcium channel, voltage-dependent, L type, alpha 1... 4319 0.0
gi|192807300 calcium channel, voltage-dependent, L type, alpha 1... 4302 0.0
gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D ... 4276 0.0
gi|193788536 calcium channel, voltage-dependent, L type, alpha 1... 2757 0.0
gi|193788548 calcium channel, voltage-dependent, L type, alpha 1... 2755 0.0
gi|193788538 calcium channel, voltage-dependent, L type, alpha 1... 2747 0.0
gi|193788730 calcium channel, voltage-dependent, L type, alpha 1... 2747 0.0
gi|193788540 calcium channel, voltage-dependent, L type, alpha 1... 2747 0.0
gi|193788542 calcium channel, voltage-dependent, L type, alpha 1... 2746 0.0
gi|120433602 calcium channel, voltage-dependent, L type, alpha 1... 2746 0.0
gi|193788544 calcium channel, voltage-dependent, L type, alpha 1... 2746 0.0
gi|193794830 calcium channel, voltage-dependent, L type, alpha 1... 2745 0.0
gi|193788534 calcium channel, voltage-dependent, L type, alpha 1... 2743 0.0
gi|193788532 calcium channel, voltage-dependent, L type, alpha 1... 2742 0.0
gi|193788526 calcium channel, voltage-dependent, L type, alpha 1... 2737 0.0
gi|193794832 calcium channel, voltage-dependent, L type, alpha 1... 2737 0.0
gi|193788732 calcium channel, voltage-dependent, L type, alpha 1... 2736 0.0
gi|193794828 calcium channel, voltage-dependent, L type, alpha 1... 2735 0.0
gi|193788530 calcium channel, voltage-dependent, L type, alpha 1... 2735 0.0
gi|193788528 calcium channel, voltage-dependent, L type, alpha 1... 2734 0.0
gi|193788720 calcium channel, voltage-dependent, L type, alpha 1... 2728 0.0
gi|193788724 calcium channel, voltage-dependent, L type, alpha 1... 2728 0.0
gi|193788728 calcium channel, voltage-dependent, L type, alpha 1... 2726 0.0
gi|53832007 calcium channel, voltage-dependent, L type, alpha 1F... 2397 0.0
gi|110349767 calcium channel, voltage-dependent, L type, alpha 1... 2266 0.0
gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo s... 781 0.0
gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo s... 772 0.0
gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B ... 765 0.0
gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E... 733 0.0
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor... 426 e-118
>gi|192807298 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform c [Homo sapiens]
Length = 2137
Score = 4320 bits (11203), Expect = 0.0
Identities = 2137/2137 (100%), Positives = 2137/2137 (100%)
Query: 1 MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA 60
MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA
Sbjct: 1 MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA 60
Query: 61 RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI 120
RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI
Sbjct: 61 RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI 120
Query: 121 SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI 180
SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI
Sbjct: 121 SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI 180
Query: 181 IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR 240
IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR
Sbjct: 181 IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR 240
Query: 241 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT 300
AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT
Sbjct: 241 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT 300
Query: 301 CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360
CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC
Sbjct: 301 CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360
Query: 361 ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG 420
ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG
Sbjct: 361 ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG 420
Query: 421 DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS 480
DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS
Sbjct: 421 DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS 480
Query: 481 GEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTI 540
GEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTI
Sbjct: 481 GEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTI 540
Query: 541 SSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGIT 600
SSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGIT
Sbjct: 541 SSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGIT 600
Query: 601 ETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLF 660
ETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLF
Sbjct: 601 ETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLF 660
Query: 661 IIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGG 720
IIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGG
Sbjct: 661 IIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGG 720
Query: 721 PSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARK 780
PSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARK
Sbjct: 721 PSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARK 780
Query: 781 ESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEVP 840
ESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEVP
Sbjct: 781 ESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEVP 840
Query: 841 AGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSS 900
AGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSS
Sbjct: 841 AGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSS 900
Query: 901 AALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDM 960
AALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDM
Sbjct: 901 AALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDM 960
Query: 961 LVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMI 1020
LVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMI
Sbjct: 961 LVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMI 1020
Query: 1021 VTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNS 1080
VTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNS
Sbjct: 1021 VTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNS 1080
Query: 1081 DFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVA 1140
DFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVA
Sbjct: 1081 DFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVA 1140
Query: 1141 FFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWY 1200
FFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWY
Sbjct: 1141 FFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWY 1200
Query: 1201 VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFK 1260
VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFK
Sbjct: 1201 VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFK 1260
Query: 1261 PKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMRLVKLLSRGEG 1320
PKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMRLVKLLSRGEG
Sbjct: 1261 PKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMRLVKLLSRGEG 1320
Query: 1321 IRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQA 1380
IRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQA
Sbjct: 1321 IRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQA 1380
Query: 1381 VLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLI 1440
VLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLI
Sbjct: 1381 VLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLI 1440
Query: 1441 INLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPP 1500
INLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPP
Sbjct: 1441 INLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPP 1500
Query: 1501 LGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRA 1560
LGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRA
Sbjct: 1501 LGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRA 1560
Query: 1561 VIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKN 1620
VIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKN
Sbjct: 1561 VIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKN 1620
Query: 1621 TTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEETKREEEDDVFKRNGALLGNHVNHVNS 1680
TTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEETKREEEDDVFKRNGALLGNHVNHVNS
Sbjct: 1621 TTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEETKREEEDDVFKRNGALLGNHVNHVNS 1680
Query: 1681 DRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTN 1740
DRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTN
Sbjct: 1681 DRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTN 1740
Query: 1741 ANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSSVKRSDSGDEQLPTIC 1800
ANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSSVKRSDSGDEQLPTIC
Sbjct: 1741 ANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSSVKRSDSGDEQLPTIC 1800
Query: 1801 REDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGY 1860
REDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGY
Sbjct: 1801 REDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGY 1860
Query: 1861 HHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFP 1920
HHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFP
Sbjct: 1861 HHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFP 1920
Query: 1921 HRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVE 1980
HRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVE
Sbjct: 1921 HRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVE 1980
Query: 1981 QSEALDQVNGSLPSLHRSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEA 2040
QSEALDQVNGSLPSLHRSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEA
Sbjct: 1981 QSEALDQVNGSLPSLHRSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEA 2040
Query: 2041 VLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSH 2100
VLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSH
Sbjct: 2041 VLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSH 2100
Query: 2101 RQDYELQDFGPGYSDEEPDPGRDEEDLADEMICITTL 2137
RQDYELQDFGPGYSDEEPDPGRDEEDLADEMICITTL
Sbjct: 2101 RQDYELQDFGPGYSDEEPDPGRDEEDLADEMICITTL 2137
>gi|192807300 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform b [Homo sapiens]
Length = 2161
Score = 4302 bits (11157), Expect = 0.0
Identities = 2137/2161 (98%), Positives = 2137/2161 (98%), Gaps = 24/2161 (1%)
Query: 1 MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA 60
MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA
Sbjct: 1 MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA 60
Query: 61 RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI 120
RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI
Sbjct: 61 RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI 120
Query: 121 SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI 180
SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI
Sbjct: 121 SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI 180
Query: 181 IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR 240
IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR
Sbjct: 181 IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR 240
Query: 241 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT 300
AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT
Sbjct: 241 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT 300
Query: 301 CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360
CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC
Sbjct: 301 CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360
Query: 361 ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG 420
ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG
Sbjct: 361 ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG 420
Query: 421 DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS 480
DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS
Sbjct: 421 DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS 480
Query: 481 GEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTI 540
GEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTI
Sbjct: 481 GEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTI 540
Query: 541 SSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGIT 600
SSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGIT
Sbjct: 541 SSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGIT 600
Query: 601 ETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLF 660
ETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLF
Sbjct: 601 ETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLF 660
Query: 661 IIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGG 720
IIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGG
Sbjct: 661 IIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGG 720
Query: 721 PSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARK 780
PSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARK
Sbjct: 721 PSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARK 780
Query: 781 ESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEVP 840
ESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEVP
Sbjct: 781 ESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEVP 840
Query: 841 AGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSS 900
AGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSS
Sbjct: 841 AGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSS 900
Query: 901 AALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDM 960
AALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDM
Sbjct: 901 AALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDM 960
Query: 961 LVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMI 1020
LVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMI
Sbjct: 961 LVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMI 1020
Query: 1021 VTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNS 1080
VTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNS
Sbjct: 1021 VTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNS 1080
Query: 1081 DFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVA 1140
DFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVA
Sbjct: 1081 DFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVA 1140
Query: 1141 FFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWY 1200
FFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWY
Sbjct: 1141 FFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWY 1200
Query: 1201 VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFK 1260
VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFK
Sbjct: 1201 VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFK 1260
Query: 1261 PKGYFSDAWNTFDSLIVIGSIIDVALSEAD---------------NSEESNRISITFFRL 1305
PKGYFSDAWNTFDSLIVIGSIIDVALSEAD NSEESNRISITFFRL
Sbjct: 1261 PKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRL 1320
Query: 1306 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDN 1365
FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDN
Sbjct: 1321 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDN 1380
Query: 1366 NQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFA 1425
NQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFA
Sbjct: 1381 NQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFA 1440
Query: 1426 IVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRI 1485
IVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRI
Sbjct: 1441 IVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRI 1500
Query: 1486 KHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKI 1545
KHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKI
Sbjct: 1501 KHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKI 1560
Query: 1546 KTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFK 1605
KTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFK
Sbjct: 1561 KTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFK 1620
Query: 1606 KRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEETKREEEDDVFK 1665
KRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEETKREEEDDVFK
Sbjct: 1621 KRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEETKREEEDDVFK 1680
Query: 1666 RNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNH 1725
RNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNH
Sbjct: 1681 RNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNH 1740
Query: 1726 HNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSS 1785
HNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSS
Sbjct: 1741 HNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSS 1800
Query: 1786 VK---------RSDSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSPTW 1836
VK RSDSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSPTW
Sbjct: 1801 VKRTRYYETYIRSDSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSPTW 1860
Query: 1837 SRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRR 1896
SRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRR
Sbjct: 1861 SRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRR 1920
Query: 1897 SSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRS 1956
SSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRS
Sbjct: 1921 SSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRS 1980
Query: 1957 WATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEPDISYRTFTPAS 2016
WATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEPDISYRTFTPAS
Sbjct: 1981 WATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEPDISYRTFTPAS 2040
Query: 2017 LTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEME 2076
LTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEME
Sbjct: 2041 LTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEME 2100
Query: 2077 SAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGRDEEDLADEMICITT 2136
SAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGRDEEDLADEMICITT
Sbjct: 2101 SAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGRDEEDLADEMICITT 2160
Query: 2137 L 2137
L
Sbjct: 2161 L 2161
>gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform a [Homo sapiens]
Length = 2181
Score = 4276 bits (11089), Expect = 0.0
Identities = 2130/2181 (97%), Positives = 2134/2181 (97%), Gaps = 44/2181 (2%)
Query: 1 MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA 60
MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA
Sbjct: 1 MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA 60
Query: 61 RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI 120
RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI
Sbjct: 61 RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI 120
Query: 121 SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI 180
SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI
Sbjct: 121 SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI 180
Query: 181 IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR 240
IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR
Sbjct: 181 IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR 240
Query: 241 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT 300
AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT
Sbjct: 241 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT 300
Query: 301 CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360
CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC
Sbjct: 301 CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360
Query: 361 ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG 420
ITMEGWTDVLYW+NDA+G+E PWVYFVSL+I GSFFVLNLVLGVLSGEFSKEREKAKARG
Sbjct: 361 ITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKARG 420
Query: 421 DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS 480
DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS
Sbjct: 421 DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS 480
Query: 481 GEGENRGCCGSLC--------------------QAISKSKLSRRWRRWNRFNRRRCRAAV 520
GEGENRGCCGSL QAISKSKLSRRWRRWNRFNRRRCRAAV
Sbjct: 481 GEGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSRRWRRWNRFNRRRCRAAV 540
Query: 521 KSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ 580
KSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ
Sbjct: 541 KSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ 600
Query: 581 AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLV 640
AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLV
Sbjct: 601 AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLV 660
Query: 641 ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQ 700
ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQ
Sbjct: 661 ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQ 720
Query: 701 ILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES 760
ILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES
Sbjct: 721 ILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES 780
Query: 761 LNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPP 820
LNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPP
Sbjct: 781 LNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPP 840
Query: 821 CDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCH 880
CDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCH
Sbjct: 841 CDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCH 900
Query: 881 KLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTT 940
KLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTT
Sbjct: 901 KLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTT 960
Query: 941 FGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKG 1000
FGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKG
Sbjct: 961 FGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKG 1020
Query: 1001 LKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFI 1060
LKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFI
Sbjct: 1021 LKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFI 1080
Query: 1061 LYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGP 1120
LYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGP
Sbjct: 1081 LYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGP 1140
Query: 1121 IYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYAL 1180
IYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYAL
Sbjct: 1141 IYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYAL 1200
Query: 1181 KARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDIL 1240
KARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDIL
Sbjct: 1201 KARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDIL 1260
Query: 1241 NMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEAD---------- 1290
NMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEAD
Sbjct: 1261 NMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVP 1320
Query: 1291 -----NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML 1345
NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML
Sbjct: 1321 TATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML 1380
Query: 1346 FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL 1405
FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL
Sbjct: 1381 FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL 1440
Query: 1406 CDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH 1465
CDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH
Sbjct: 1441 CDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH 1500
Query: 1466 HLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS 1525
HLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS
Sbjct: 1501 HLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS 1560
Query: 1526 DGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDE 1585
DGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDE
Sbjct: 1561 DGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDE 1620
Query: 1586 VTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISC 1645
VTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISC
Sbjct: 1621 VTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISC 1680
Query: 1646 DLQDDEPEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPP 1705
DLQDDEPEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPP
Sbjct: 1681 DLQDDEPEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPP 1740
Query: 1706 ASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHV 1765
ASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHV
Sbjct: 1741 ASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHV 1800
Query: 1766 SENGHHSSHKHDREPQRRSSVK---------RSDSGDEQLPTICREDPEIHGYFRDPHCL 1816
SENGHHSSHKHDREPQRRSSVK RSDSGDEQLPTICREDPEIHGYFRDPHCL
Sbjct: 1801 SENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYFRDPHCL 1860
Query: 1817 GEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCY 1876
GEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCY
Sbjct: 1861 GEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCY 1920
Query: 1877 DSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMA 1936
DSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMA
Sbjct: 1921 DSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMA 1980
Query: 1937 VAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLH 1996
VAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLH
Sbjct: 1981 VAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLH 2040
Query: 1997 RSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKF 2056
RSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKF
Sbjct: 2041 RSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKF 2100
Query: 2057 VSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDE 2116
VSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDE
Sbjct: 2101 VSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDE 2160
Query: 2117 EPDPGRDEEDLADEMICITTL 2137
EPDPGRDEEDLADEMICITTL
Sbjct: 2161 EPDPGRDEEDLADEMICITTL 2181
>gi|193788536 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 14 [Homo sapiens]
Length = 2138
Score = 2757 bits (7147), Expect = 0.0
Identities = 1460/2156 (67%), Positives = 1663/2156 (77%), Gaps = 136/2156 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYWM DAMG+ELPWVYFVSLVIFGSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN ILG DY
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF DAWNTFD+LIV+GSI+D+A
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1286 LSEAD-----------NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1334
++E + N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA
Sbjct: 1300 ITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1359
Query: 1335 LPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQ 1394
LPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATGEAWQ
Sbjct: 1360 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1419
Query: 1395 EIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1452
+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVIMDNF
Sbjct: 1420 DIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479
Query: 1453 DYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA 1512
DYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA
Sbjct: 1480 DYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA 1539
Query: 1513 CKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMK 1572
CKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTEGNLEQANEELRA+IKKIWK+TSMK
Sbjct: 1540 CKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMK 1599
Query: 1573 LLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTL 1632
LLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAGLRTL
Sbjct: 1600 LLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAGLRTL 1658
Query: 1633 HDIGPEIRRAISCDLQDDE------PEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSL 1686
HDIGPEIRRAIS DL +E E EDD+F+R G L GNHV++ SD R +
Sbjct: 1659 HDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAF 1718
Query: 1687 QQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNA 1746
QT TT RPLH+ + DTE P +S +++S T +NAN+NNA
Sbjct: 1719 PQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNANINNA 1770
Query: 1747 NMSKAAHGKRPSIGNLEHVSENGH-----------------HSSHKHDREPQRRSSVKRS 1789
N + RP+ + GH S+ H RE Q + +
Sbjct: 1771 NNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEE 1830
Query: 1790 DSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRYP 1848
S DE D E E S+E Y+DD
Sbjct: 1831 TSQDETYEVKMNHDTE---------ACSEPSLLSTEMLSYQDD----------------- 1864
Query: 1849 GRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQS 1908
+ Q L ++D D R+SP+R L + + RR+SF+ ECL+RQ
Sbjct: 1865 ------------ENRQLTLPEEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQK 1908
Query: 1909 SQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRD 1968
+ +T LPLHL+ Q +AVAGL + +SP+ R +ATPPATP R
Sbjct: 1909 DR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRG 1963
Query: 1969 WTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSFR 2024
W P P +++E E+ +++N S PS+H SW P + R P SL VPS
Sbjct: 1964 WPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAG 2023
Query: 2025 NKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLN 2084
SA SLVEAVLISEGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L+
Sbjct: 2024 APGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILS 2083
Query: 2085 GNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2137
G NG + P + +D QD G D R EE+L D + +++L
Sbjct: 2084 GGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2138
>gi|193788548 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 20 [Homo sapiens]
Length = 2127
Score = 2755 bits (7141), Expect = 0.0
Identities = 1453/2145 (67%), Positives = 1661/2145 (77%), Gaps = 125/2145 (5%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN ILG DY
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF DAWNTFD+LIV+GSI+D+A
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1286 LSEADNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML 1345
++E +N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI ML
Sbjct: 1300 ITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVML 1359
Query: 1346 FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL 1405
FFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK
Sbjct: 1360 FFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKK 1419
Query: 1406 CDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILG 1463
C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILG
Sbjct: 1420 CAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILG 1479
Query: 1464 PHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPL 1523
PHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPL
Sbjct: 1480 PHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPL 1539
Query: 1524 NSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGD 1583
NSDGTVMFNATLFALVRTAL+IKTEGNLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGD
Sbjct: 1540 NSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGD 1599
Query: 1584 DEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAI 1643
DEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAGLRTLHDIGPEIRRAI
Sbjct: 1600 DEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAI 1658
Query: 1644 SCDLQDDE------PEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLH 1697
S DL +E E EDD+F+R G L GNHV++ SD R + QT TT RPLH
Sbjct: 1659 SGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLH 1718
Query: 1698 VQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRP 1757
+ + DTE P +S +++S T +NAN+NNAN + RP
Sbjct: 1719 INKAG-SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNANINNANNTALGRLPRP 1770
Query: 1758 SIGNLEHVSENGH-----------------HSSHKHDREPQRRSSVKRSDSGDEQLPTIC 1800
+ + GH S+ H RE Q + + S DE
Sbjct: 1771 AGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKM 1830
Query: 1801 REDPEIHGYFRDPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRG 1859
D E E S+E Y+DD
Sbjct: 1831 NHDTE---------ACSEPSLLSTEMLSYQDD---------------------------- 1853
Query: 1860 YHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIF 1919
+ Q L ++D D R+SP+R L + + RR+SF+ ECL+RQ +
Sbjct: 1854 -ENRQLTLPEEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQKDR-----GGDI 1903
Query: 1920 PHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQV 1979
+T LPLHL+ Q +AVAGL + +SP+ R +ATPPATP R W P P +++
Sbjct: 1904 SQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRL 1963
Query: 1980 EQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSFRNKNSDKQRSAD 2035
E E+ +++N S PS+H SW P + R P SL VPS SA
Sbjct: 1964 EGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSAS 2023
Query: 2036 SLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDV 2095
SLVEAVLISEGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L+G NG +
Sbjct: 2024 SLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGAL 2083
Query: 2096 GPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2137
P + +D QD G D R EE+L D + +++L
Sbjct: 2084 LPFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2127
>gi|193788538 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 15 [Homo sapiens]
Length = 2138
Score = 2748 bits (7122), Expect = 0.0
Identities = 1457/2156 (67%), Positives = 1659/2156 (76%), Gaps = 136/2156 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN ILG DY
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPKGYFSD WN FD LIVIGSIIDV
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVI 1299
Query: 1286 LSEAD-----------NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1334
LSE + N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA
Sbjct: 1300 LSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1359
Query: 1335 LPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQ 1394
LPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATGEAWQ
Sbjct: 1360 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1419
Query: 1395 EIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1452
+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVIMDNF
Sbjct: 1420 DIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479
Query: 1453 DYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA 1512
DYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA
Sbjct: 1480 DYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA 1539
Query: 1513 CKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMK 1572
CKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTEGNLEQANEELRA+IKKIWK+TSMK
Sbjct: 1540 CKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMK 1599
Query: 1573 LLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTL 1632
LLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAGLRTL
Sbjct: 1600 LLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAGLRTL 1658
Query: 1633 HDIGPEIRRAISCDLQDDE------PEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSL 1686
HDIGPEIRRAIS DL +E E EDD+F+R G L GNHV++ SD R +
Sbjct: 1659 HDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAF 1718
Query: 1687 QQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNA 1746
QT TT RPLH+ + DTE P +S +++S T +NAN+NNA
Sbjct: 1719 PQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNANINNA 1770
Query: 1747 NMSKAAHGKRPSIGNLEHVSENGH-----------------HSSHKHDREPQRRSSVKRS 1789
N + RP+ + GH S+ H RE Q + +
Sbjct: 1771 NNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEE 1830
Query: 1790 DSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRYP 1848
S DE D E E S+E Y+DD
Sbjct: 1831 TSQDETYEVKMNHDTE---------ACSEPSLLSTEMLSYQDD----------------- 1864
Query: 1849 GRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQS 1908
+ Q L ++D D R+SP+R L + + RR+SF+ ECL+RQ
Sbjct: 1865 ------------ENRQLTLPEEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQK 1908
Query: 1909 SQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRD 1968
+ +T LPLHL+ Q +AVAGL + +SP+ R +ATPPATP R
Sbjct: 1909 DR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRG 1963
Query: 1969 WTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSFR 2024
W P P +++E E+ +++N S PS+H SW P + R P SL VPS
Sbjct: 1964 WPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAG 2023
Query: 2025 NKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLN 2084
SA SLVEAVLISEGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L+
Sbjct: 2024 APGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILS 2083
Query: 2085 GNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2137
G NG + P + +D QD G D R EE+L D + +++L
Sbjct: 2084 GGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2138
>gi|193788730 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 4 [Homo sapiens]
Length = 2173
Score = 2747 bits (7120), Expect = 0.0
Identities = 1456/2161 (67%), Positives = 1670/2161 (77%), Gaps = 111/2161 (5%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN ILG DY
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF DAWNTFD+LIV+GSI+D+A
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1286 LSEAD-----------NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1334
++E + N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA
Sbjct: 1300 ITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1359
Query: 1335 LPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQ 1394
LPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATGEAWQ
Sbjct: 1360 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1419
Query: 1395 EIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1452
+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVIMDNF
Sbjct: 1420 DIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479
Query: 1453 DYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA 1512
DYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA
Sbjct: 1480 DYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA 1539
Query: 1513 CKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMK 1572
CKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTEGNLEQANEELRA+IKKIWK+TSMK
Sbjct: 1540 CKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMK 1599
Query: 1573 LLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTL 1632
LLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAGLRTL
Sbjct: 1600 LLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAGLRTL 1658
Query: 1633 HDIGPEIRRAISCDLQDDE------PEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSL 1686
HDIGPEIRRAIS DL +E E EDD+F+R G L GNHV++ SD R +
Sbjct: 1659 HDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAF 1718
Query: 1687 QQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNA 1746
QT TT RPLH+ + DTE P +S +++S T +NAN+NNA
Sbjct: 1719 PQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNANINNA 1770
Query: 1747 NMSKAAHGKRPSIGNLEHVSENGHH-----------------SSHKHDREPQRRSSVKRS 1789
N + RP+ G VS H SS++ P R
Sbjct: 1771 NNTALGRLPRPA-GYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRERHVPMCEDLELRR 1829
Query: 1790 DSGDEQLPTIC----REDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSPTWSRQNYGYYS 1845
DSG C + +P + QE S +E YE + N+ +
Sbjct: 1830 DSGSAGTQAHCLLLRKANPSRCHSRESQAAMAGQEETSQDETYE-------VKMNHDTEA 1882
Query: 1846 RYPGRNIDSE--RPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFEC 1903
+ +E + + Q L ++D D R+SP+R L + + RR+SF+ EC
Sbjct: 1883 CSEPSLLSTEMLSYQDDENRQLTLPEEDK---RDIRQSPKRGFL-RSASLGRRASFHLEC 1938
Query: 1904 LRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPAT 1963
L+RQ + +T LPLHL+ Q +AVAGL + +SP+ R +ATPPAT
Sbjct: 1939 LKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPAT 1993
Query: 1964 PPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPASLTV 2019
P R W P P +++E E+ +++N S PS+H SW P + R P SL V
Sbjct: 1994 PGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMV 2053
Query: 2020 PSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAA 2079
PS SA SLVEAVLISEGLG++A+DPKF+ T E+ADACD+TI+EMESAA
Sbjct: 2054 PSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAA 2113
Query: 2080 STLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMICITT 2136
+L+G NG + P + +D QD G D R EE+L D + +++
Sbjct: 2114 DNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSS 2172
Query: 2137 L 2137
L
Sbjct: 2173 L 2173
>gi|193788540 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 16 [Homo sapiens]
Length = 2138
Score = 2747 bits (7120), Expect = 0.0
Identities = 1457/2156 (67%), Positives = 1657/2156 (76%), Gaps = 136/2156 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN IL YFD
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPKGYFSD WN FD LIVIGSIIDV
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVI 1299
Query: 1286 LSEAD-----------NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1334
LSE + N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA
Sbjct: 1300 LSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1359
Query: 1335 LPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQ 1394
LPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATGEAWQ
Sbjct: 1360 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1419
Query: 1395 EIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1452
+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVIMDNF
Sbjct: 1420 DIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479
Query: 1453 DYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA 1512
DYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA
Sbjct: 1480 DYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA 1539
Query: 1513 CKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMK 1572
CKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTEGNLEQANEELRA+IKKIWK+TSMK
Sbjct: 1540 CKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMK 1599
Query: 1573 LLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTL 1632
LLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAGLRTL
Sbjct: 1600 LLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAGLRTL 1658
Query: 1633 HDIGPEIRRAISCDLQDDE------PEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSL 1686
HDIGPEIRRAIS DL +E E EDD+F+R G L GNHV++ SD R +
Sbjct: 1659 HDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAF 1718
Query: 1687 QQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNA 1746
QT TT RPLH+ + DTE P +S +++S T +NAN+NNA
Sbjct: 1719 PQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNANINNA 1770
Query: 1747 NMSKAAHGKRPSIGNLEHVSENGH-----------------HSSHKHDREPQRRSSVKRS 1789
N + RP+ + GH S+ H RE Q + +
Sbjct: 1771 NNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEE 1830
Query: 1790 DSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRYP 1848
S DE D E E S+E Y+DD
Sbjct: 1831 TSQDETYEVKMNHDTE---------ACSEPSLLSTEMLSYQDD----------------- 1864
Query: 1849 GRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQS 1908
+ Q L ++D D R+SP+R L + + RR+SF+ ECL+RQ
Sbjct: 1865 ------------ENRQLTLPEEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQK 1908
Query: 1909 SQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRD 1968
+ +T LPLHL+ Q +AVAGL + +SP+ R +ATPPATP R
Sbjct: 1909 DR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRG 1963
Query: 1969 WTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSFR 2024
W P P +++E E+ +++N S PS+H SW P + R P SL VPS
Sbjct: 1964 WPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAG 2023
Query: 2025 NKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLN 2084
SA SLVEAVLISEGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L+
Sbjct: 2024 APGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILS 2083
Query: 2085 GNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2137
G NG + P + +D QD G D R EE+L D + +++L
Sbjct: 2084 GGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2138
>gi|193788542 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 17 [Homo sapiens]
Length = 2138
Score = 2746 bits (7119), Expect = 0.0
Identities = 1453/2156 (67%), Positives = 1661/2156 (77%), Gaps = 136/2156 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN ILG DY
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF DAWNTFD+LIV+GSI+D+A
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1286 LSEAD-----------NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1334
++E + N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA
Sbjct: 1300 ITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1359
Query: 1335 LPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQ 1394
LPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATGEAWQ
Sbjct: 1360 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1419
Query: 1395 EIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1452
+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVIMDNF
Sbjct: 1420 DIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479
Query: 1453 DYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA 1512
DYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA
Sbjct: 1480 DYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA 1539
Query: 1513 CKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMK 1572
CKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTEGNLEQANEELRA+IKKIWK+TSMK
Sbjct: 1540 CKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMK 1599
Query: 1573 LLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTL 1632
LLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAGLRTL
Sbjct: 1600 LLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAGLRTL 1658
Query: 1633 HDIGPEIRRAISCDLQDDE------PEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSL 1686
HDIGPEIRRAIS DL +E E EDD+F+R G L GNHV++ SD R +
Sbjct: 1659 HDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAF 1718
Query: 1687 QQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNA 1746
QT TT RPLH+ + DTE P +S +++S T +NAN+NNA
Sbjct: 1719 PQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNANINNA 1770
Query: 1747 NMSKAAHGKRPSIGNLEHVSENGH-----------------HSSHKHDREPQRRSSVKRS 1789
N + RP+ + GH S+ H RE Q + +
Sbjct: 1771 NNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEE 1830
Query: 1790 DSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRYP 1848
S DE D E E S+E Y+DD
Sbjct: 1831 TSQDETYEVKMNHDTE---------ACSEPSLLSTEMLSYQDD----------------- 1864
Query: 1849 GRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQS 1908
+ Q L ++D D R+SP+R L + + RR+SF+ ECL+RQ
Sbjct: 1865 ------------ENRQLTLPEEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQK 1908
Query: 1909 SQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRD 1968
+ +T LPLHL+ Q +AVAGL + +SP+ R +ATPPATP R
Sbjct: 1909 DR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRG 1963
Query: 1969 WTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSFR 2024
W P P +++E E+ +++N S PS+H SW P + R P SL VPS
Sbjct: 1964 WPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAG 2023
Query: 2025 NKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLN 2084
SA SLVEAVLISEGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L+
Sbjct: 2024 APGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILS 2083
Query: 2085 GNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2137
G NG + P + +D QD G D R EE+L D + +++L
Sbjct: 2084 GGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2138
>gi|120433602 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 18 [Homo sapiens]
Length = 2138
Score = 2746 bits (7117), Expect = 0.0
Identities = 1453/2156 (67%), Positives = 1659/2156 (76%), Gaps = 136/2156 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN IL YFD
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF DAWNTFD+LIV+GSI+D+A
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1286 LSEAD-----------NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1334
++E + N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA
Sbjct: 1300 ITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1359
Query: 1335 LPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQ 1394
LPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATGEAWQ
Sbjct: 1360 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1419
Query: 1395 EIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1452
+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVIMDNF
Sbjct: 1420 DIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479
Query: 1453 DYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA 1512
DYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA
Sbjct: 1480 DYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA 1539
Query: 1513 CKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMK 1572
CKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTEGNLEQANEELRA+IKKIWK+TSMK
Sbjct: 1540 CKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMK 1599
Query: 1573 LLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTL 1632
LLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAGLRTL
Sbjct: 1600 LLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAGLRTL 1658
Query: 1633 HDIGPEIRRAISCDLQDDE------PEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSL 1686
HDIGPEIRRAIS DL +E E EDD+F+R G L GNHV++ SD R +
Sbjct: 1659 HDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAF 1718
Query: 1687 QQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNA 1746
QT TT RPLH+ + DTE P +S +++S T +NAN+NNA
Sbjct: 1719 PQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNANINNA 1770
Query: 1747 NMSKAAHGKRPSIGNLEHVSENGH-----------------HSSHKHDREPQRRSSVKRS 1789
N + RP+ + GH S+ H RE Q + +
Sbjct: 1771 NNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEE 1830
Query: 1790 DSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRYP 1848
S DE D E E S+E Y+DD
Sbjct: 1831 TSQDETYEVKMNHDTE---------ACSEPSLLSTEMLSYQDD----------------- 1864
Query: 1849 GRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQS 1908
+ Q L ++D D R+SP+R L + + RR+SF+ ECL+RQ
Sbjct: 1865 ------------ENRQLTLPEEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQK 1908
Query: 1909 SQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRD 1968
+ +T LPLHL+ Q +AVAGL + +SP+ R +ATPPATP R
Sbjct: 1909 DR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRG 1963
Query: 1969 WTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSFR 2024
W P P +++E E+ +++N S PS+H SW P + R P SL VPS
Sbjct: 1964 WPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAG 2023
Query: 2025 NKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLN 2084
SA SLVEAVLISEGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L+
Sbjct: 2024 APGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILS 2083
Query: 2085 GNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2137
G NG + P + +D QD G D R EE+L D + +++L
Sbjct: 2084 GGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2138
>gi|193788544 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 19 [Homo sapiens]
Length = 2135
Score = 2746 bits (7117), Expect = 0.0
Identities = 1457/2154 (67%), Positives = 1655/2154 (76%), Gaps = 135/2154 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFADSDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNFDN 349
ELF+GKMHKTC+ + I AE+DP+PCA +G+GRQC NGT C+ GW GP GITNFDN
Sbjct: 288 ELFMGKMHKTCYNQEG-IAAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDN 345
Query: 350 FAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 409
FAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSGEF
Sbjct: 346 FAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 405
Query: 410 SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSMPT 468
SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SMPT
Sbjct: 406 SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPT 465
Query: 469 SETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTF 525
SETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS F
Sbjct: 466 SETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVF 523
Query: 526 YWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVS 585
YWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYFVS
Sbjct: 524 YWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVS 583
Query: 586 LFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLN 645
LFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASLLN
Sbjct: 584 LFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLN 643
Query: 646 SMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGE 705
S++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILTGE
Sbjct: 644 SVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGE 703
Query: 706 DWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQ 765
DWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +AQ
Sbjct: 704 DWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQ 763
Query: 766 KEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTIDDY 808
KEE EEKERKK+AR S E K+ KP V + K+ +DD
Sbjct: 764 KEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMDDL 823
Query: 809 R-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFF 867
+ E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SAFF
Sbjct: 824 QPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFF 878
Query: 868 ILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFT 927
I S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN IL YFD FT
Sbjct: 879 IFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFT 938
Query: 928 AIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLR 987
IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRVLR
Sbjct: 939 TIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLR 998
Query: 988 VLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDE 1047
VLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+D
Sbjct: 999 VLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDS 1058
Query: 1048 AKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALL 1107
+K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP LL
Sbjct: 1059 SKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELL 1118
Query: 1108 YKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCE 1167
Y++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKNCE
Sbjct: 1119 YRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCE 1178
Query: 1168 LDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHY 1227
LDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQHY
Sbjct: 1179 LDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHY 1238
Query: 1228 EQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALS 1287
QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPKGYFSD WN FD LIVIGSIIDV LS
Sbjct: 1239 GQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILS 1298
Query: 1288 EAD-----------NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALP 1336
E + N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALP
Sbjct: 1299 ETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALP 1358
Query: 1337 YVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEI 1396
YVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATGEAWQ+I
Sbjct: 1359 YVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDI 1418
Query: 1397 MLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDY 1454
MLAC+PGK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVIMDNFDY
Sbjct: 1419 MLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDY 1478
Query: 1455 LTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACK 1514
LTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACK
Sbjct: 1479 LTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACK 1538
Query: 1515 RLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLL 1574
RLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTEGNLEQANEELRA+IKKIWK+TSMKLL
Sbjct: 1539 RLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLL 1598
Query: 1575 DQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHD 1634
DQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAGLRTLHD
Sbjct: 1599 DQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAGLRTLHD 1657
Query: 1635 IGPEIRRAISCDLQDDE------PEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQ 1688
IGPEIRRAIS DL +E E EDD+F+R G L GNHV++ SD R + Q
Sbjct: 1658 IGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQ 1717
Query: 1689 TNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANM 1748
T TT RPLH+ + DTE P +S +++S T +NAN+NNAN
Sbjct: 1718 TFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNANINNANN 1769
Query: 1749 SKAAHGKRPSIGNLEHVSENGH-----------------HSSHKHDREPQRRSSVKRSDS 1791
+ RP+ + GH S+ H RE Q + + S
Sbjct: 1770 TALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEETS 1829
Query: 1792 GDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRYPGR 1850
DE D E E S+E Y+DD
Sbjct: 1830 QDETYEVKMNHDTE---------ACSEPSLLSTEMLSYQDD------------------- 1861
Query: 1851 NIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQ 1910
+ Q L ++D D R+SP+R L + + RR+SF+ ECL+RQ +
Sbjct: 1862 ----------ENRQLTLPEEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQKDR 1907
Query: 1911 EEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWT 1970
+T LPLHL+ Q +AVAGL + +SP+ R +ATPPATP R W
Sbjct: 1908 -----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWP 1962
Query: 1971 PCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSFRNK 2026
P P +++E E+ +++N S PS+H SW P + R P SL VPS
Sbjct: 1963 PQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAP 2022
Query: 2027 NSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNGN 2086
SA SLVEAVLISEGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L+G
Sbjct: 2023 GRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGG 2082
Query: 2087 VRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2137
NG + P + +D QD G D R EE+L D + +++L
Sbjct: 2083 APQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2135
>gi|193794830 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 10 [Homo sapiens]
Length = 2155
Score = 2745 bits (7115), Expect = 0.0
Identities = 1455/2173 (66%), Positives = 1663/2173 (76%), Gaps = 153/2173 (7%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN ILG DY
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFS------------------- 1266
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPKGYFS
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVI 1299
Query: 1267 ---------DAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMRLVKLLSR 1317
DAWNTFD+LIV+GSI+D+A++E +N+EE++RISITFFRLFRVMRLVKLLSR
Sbjct: 1300 LSETNHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSR 1359
Query: 1318 GEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTF 1377
GEGIRTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTF
Sbjct: 1360 GEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTF 1419
Query: 1378 PQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYML 1435
PQAVLLLFRCATGEAWQ+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYML
Sbjct: 1420 PQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYML 1479
Query: 1436 CAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLR 1495
CAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLR
Sbjct: 1480 CAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLR 1539
Query: 1496 RIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQAN 1555
RIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTEGNLEQAN
Sbjct: 1540 RIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQAN 1599
Query: 1556 EELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGK 1615
EELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK
Sbjct: 1600 EELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK 1659
Query: 1616 YPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDDVFKRNGA 1669
P++ ++LQAGLRTLHDIGPEIRRAIS DL +E E EDD+F+R G
Sbjct: 1660 -PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGG 1718
Query: 1670 LLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHN 1729
L GNHV++ SD R + QT TT RPLH+ + DTE P +S +++
Sbjct: 1719 LFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPSSYS 1776
Query: 1730 SIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGH-----------------HS 1772
S T +NAN+NNAN + RP+ + GH S
Sbjct: 1777 S------TGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSS 1830
Query: 1773 SHKHDREPQRRSSVKRSDSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEE-CYEDD 1831
+ H RE Q + + S DE D E E S+E Y+DD
Sbjct: 1831 NRCHSRESQAAMAGQEETSQDETYEVKMNHDTE---------ACSEPSLLSTEMLSYQDD 1881
Query: 1832 SSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTP 1891
+ Q L ++D D R+SP+R L +
Sbjct: 1882 -----------------------------ENRQLTLPEEDK---RDIRQSPKRGFL-RSA 1908
Query: 1892 ASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPS 1951
+ RR+SF+ ECL+RQ + +T LPLHL+ Q +AVAGL + +SP+
Sbjct: 1909 SLGRRASFHLECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPA 1963
Query: 1952 HSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DI 2007
R +ATPPATP R W P P +++E E+ +++N S PS+H SW P
Sbjct: 1964 SFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSS 2023
Query: 2008 SYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADA 2067
+ R P SL VPS SA SLVEAVLISEGLG++A+DPKF+ T E+ADA
Sbjct: 2024 AARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADA 2083
Query: 2068 CDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR---DE 2124
CD+TI+EMESAA +L+G NG + P + +D QD G D R E
Sbjct: 2084 CDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRPSE 2142
Query: 2125 EDLADEMICITTL 2137
E+L D + +++L
Sbjct: 2143 EELQDSRVYVSSL 2155
>gi|193788534 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 12 [Homo sapiens]
Length = 2146
Score = 2743 bits (7111), Expect = 0.0
Identities = 1453/2164 (67%), Positives = 1661/2164 (76%), Gaps = 144/2164 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN ILG DY
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF DAWNTFD+LIV+GSI+D+A
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1286 LSEADNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML 1345
++E +N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI ML
Sbjct: 1300 ITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVML 1359
Query: 1346 FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL 1405
FFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK
Sbjct: 1360 FFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKK 1419
Query: 1406 CDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILG 1463
C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILG
Sbjct: 1420 CAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILG 1479
Query: 1464 PHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPL 1523
PHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPL
Sbjct: 1480 PHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPL 1539
Query: 1524 NSDGTVMFNATLFALVRTALKIKTE-------------------GNLEQANEELRAVIKK 1564
NSDGTVMFNATLFALVRTAL+IKTE GNLEQANEELRA+IKK
Sbjct: 1540 NSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKK 1599
Query: 1565 IWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIA 1624
IWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++
Sbjct: 1600 IWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALS 1658
Query: 1625 LQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDDVFKRNGALLGNHVNHV 1678
LQAGLRTLHDIGPEIRRAIS DL +E E EDD+F+R G L GNHV++
Sbjct: 1659 LQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYY 1718
Query: 1679 NSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTS 1738
SD R + QT TT RPLH+ + DTE P +S +++S T
Sbjct: 1719 QSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPSSYSS------TG 1770
Query: 1739 TNANLNNANMSKAAHGKRPSIGNLEHVSENGH-----------------HSSHKHDREPQ 1781
+NAN+NNAN + RP+ + GH S+ H RE Q
Sbjct: 1771 SNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQ 1830
Query: 1782 RRSSVKRSDSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEE-CYEDDSSPTWSRQN 1840
+ + S DE D E E S+E Y+DD
Sbjct: 1831 AAMAGQEETSQDETYEVKMNHDTE---------ACSEPSLLSTEMLSYQDD--------- 1872
Query: 1841 YGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFN 1900
+ Q L ++D D R+SP+R L + + RR+SF+
Sbjct: 1873 --------------------ENRQLTLPEEDK---RDIRQSPKRGFL-RSASLGRRASFH 1908
Query: 1901 FECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATP 1960
ECL+RQ + +T LPLHL+ Q +AVAGL + +SP+ R +ATP
Sbjct: 1909 LECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATP 1963
Query: 1961 PATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPAS 2016
PATP R W P P +++E E+ +++N S PS+H SW P + R P S
Sbjct: 1964 PATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVS 2023
Query: 2017 LTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEME 2076
L VPS SA SLVEAVLISEGLG++A+DPKF+ T E+ADACD+TI+EME
Sbjct: 2024 LMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEME 2083
Query: 2077 SAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMIC 2133
SAA +L+G NG + P + +D QD G D R EE+L D +
Sbjct: 2084 SAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEELQDSRVY 2142
Query: 2134 ITTL 2137
+++L
Sbjct: 2143 VSSL 2146
>gi|193788532 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 11 [Homo sapiens]
Length = 2146
Score = 2742 bits (7109), Expect = 0.0
Identities = 1453/2164 (67%), Positives = 1659/2164 (76%), Gaps = 144/2164 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN IL YFD
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF DAWNTFD+LIV+GSI+D+A
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1286 LSEADNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML 1345
++E +N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI ML
Sbjct: 1300 ITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVML 1359
Query: 1346 FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL 1405
FFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK
Sbjct: 1360 FFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKK 1419
Query: 1406 CDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILG 1463
C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILG
Sbjct: 1420 CAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILG 1479
Query: 1464 PHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPL 1523
PHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPL
Sbjct: 1480 PHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPL 1539
Query: 1524 NSDGTVMFNATLFALVRTALKIKTE-------------------GNLEQANEELRAVIKK 1564
NSDGTVMFNATLFALVRTAL+IKTE GNLEQANEELRA+IKK
Sbjct: 1540 NSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKK 1599
Query: 1565 IWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIA 1624
IWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++
Sbjct: 1600 IWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALS 1658
Query: 1625 LQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDDVFKRNGALLGNHVNHV 1678
LQAGLRTLHDIGPEIRRAIS DL +E E EDD+F+R G L GNHV++
Sbjct: 1659 LQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYY 1718
Query: 1679 NSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTS 1738
SD R + QT TT RPLH+ + DTE P +S +++S T
Sbjct: 1719 QSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPSSYSS------TG 1770
Query: 1739 TNANLNNANMSKAAHGKRPSIGNLEHVSENGH-----------------HSSHKHDREPQ 1781
+NAN+NNAN + RP+ + GH S+ H RE Q
Sbjct: 1771 SNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQ 1830
Query: 1782 RRSSVKRSDSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEE-CYEDDSSPTWSRQN 1840
+ + S DE D E E S+E Y+DD
Sbjct: 1831 AAMAGQEETSQDETYEVKMNHDTE---------ACSEPSLLSTEMLSYQDD--------- 1872
Query: 1841 YGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFN 1900
+ Q L ++D D R+SP+R L + + RR+SF+
Sbjct: 1873 --------------------ENRQLTLPEEDK---RDIRQSPKRGFL-RSASLGRRASFH 1908
Query: 1901 FECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATP 1960
ECL+RQ + +T LPLHL+ Q +AVAGL + +SP+ R +ATP
Sbjct: 1909 LECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATP 1963
Query: 1961 PATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPAS 2016
PATP R W P P +++E E+ +++N S PS+H SW P + R P S
Sbjct: 1964 PATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVS 2023
Query: 2017 LTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEME 2076
L VPS SA SLVEAVLISEGLG++A+DPKF+ T E+ADACD+TI+EME
Sbjct: 2024 LMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEME 2083
Query: 2077 SAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMIC 2133
SAA +L+G NG + P + +D QD G D R EE+L D +
Sbjct: 2084 SAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEELQDSRVY 2142
Query: 2134 ITTL 2137
+++L
Sbjct: 2143 VSSL 2146
>gi|193788526 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 6 [Homo sapiens]
Length = 2158
Score = 2737 bits (7096), Expect = 0.0
Identities = 1454/2176 (66%), Positives = 1662/2176 (76%), Gaps = 156/2176 (7%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFD-- 923
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN IL YFD
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 924 ------------------YAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGV 965
Y FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV V
Sbjct: 940 FTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSV 999
Query: 966 SLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLL 1025
SL+SFGIQSSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLL
Sbjct: 1000 SLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLL 1059
Query: 1026 QFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFD 1085
QFMFACIGVQLFKGK Y C+D +K EC+G +I YKDG+VD P+++ R W+NS F+FD
Sbjct: 1060 QFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFD 1119
Query: 1086 NVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMN 1145
NVL+AMMALFTVSTFEGWP LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMN
Sbjct: 1120 NVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMN 1179
Query: 1146 IFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSS 1205
IFVGFVIVTFQEQGE+EYKNCELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+
Sbjct: 1180 IFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNST 1239
Query: 1206 PFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYF 1265
FEY+MFVLI+LNT+CLAMQHY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF
Sbjct: 1240 YFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYF 1299
Query: 1266 SDAWNTFDSLIVIGSIIDVALSEAD-----------NSEESNRISITFFRLFRVMRLVKL 1314
DAWNTFD+LIV+GSI+D+A++E + N+EE++RISITFFRLFRVMRLVKL
Sbjct: 1300 CDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKL 1359
Query: 1315 LSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNF 1374
LSRGEGIRTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNF
Sbjct: 1360 LSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNF 1419
Query: 1375 QTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISF 1432
QTFPQAVLLLFRCATGEAWQ+IMLAC+PGK C PES+ + E CGS+FA+ YFISF
Sbjct: 1420 QTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISF 1479
Query: 1433 YMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVT 1492
YMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVT
Sbjct: 1480 YMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVT 1539
Query: 1493 LLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLE 1552
LLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTEGNLE
Sbjct: 1540 LLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLE 1599
Query: 1553 QANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGL 1612
QANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGL
Sbjct: 1600 QANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGL 1659
Query: 1613 VGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDDVFKR 1666
VGK P++ ++LQAGLRTLHDIGPEIRRAIS DL +E E EDD+F+R
Sbjct: 1660 VGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRR 1718
Query: 1667 NGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHH 1726
G L GNHV++ SD R + QT TT RPLH+ + DTE P +S
Sbjct: 1719 AGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPS 1776
Query: 1727 NHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGH---------------- 1770
+++S T +NAN+NNAN + RP+ + GH
Sbjct: 1777 SYSS------TGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWK 1830
Query: 1771 -HSSHKHDREPQRRSSVKRSDSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEE-CY 1828
S+ H RE Q + + S DE D E E S+E Y
Sbjct: 1831 LSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTE---------ACSEPSLLSTEMLSY 1881
Query: 1829 EDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLP 1888
+DD + Q L ++D D R+SP+R L
Sbjct: 1882 QDD-----------------------------ENRQLTLPEEDK---RDIRQSPKRGFL- 1908
Query: 1889 PTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKY 1948
+ + RR+SF+ ECL+RQ + +T LPLHL+ Q +AVAGL + +
Sbjct: 1909 RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSH 1963
Query: 1949 SPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP--- 2005
SP+ R +ATPPATP R W P P +++E E+ +++N S PS+H SW P
Sbjct: 1964 SPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGG 2023
Query: 2006 -DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEI 2064
+ R P SL VPS SA SLVEAVLISEGLG++A+DPKF+ T E+
Sbjct: 2024 GSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQEL 2083
Query: 2065 ADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR-- 2122
ADACD+TI+EMESAA +L+G NG + P + +D QD G D R
Sbjct: 2084 ADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGR 2142
Query: 2123 -DEEDLADEMICITTL 2137
EE+L D + +++L
Sbjct: 2143 PSEEELQDSRVYVSSL 2158
>gi|193794832 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoforom 13 [Homo sapiens]
Length = 2144
Score = 2737 bits (7095), Expect = 0.0
Identities = 1453/2164 (67%), Positives = 1658/2164 (76%), Gaps = 146/2164 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN IL YFD
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF DAWNTFD+LIV+GSI+D+A
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1286 LSEADNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML 1345
++E N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI ML
Sbjct: 1300 ITE--NAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVML 1357
Query: 1346 FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL 1405
FFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK
Sbjct: 1358 FFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKK 1417
Query: 1406 CDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILG 1463
C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILG
Sbjct: 1418 CAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILG 1477
Query: 1464 PHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPL 1523
PHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPL
Sbjct: 1478 PHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPL 1537
Query: 1524 NSDGTVMFNATLFALVRTALKIKTE-------------------GNLEQANEELRAVIKK 1564
NSDGTVMFNATLFALVRTAL+IKTE GNLEQANEELRA+IKK
Sbjct: 1538 NSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKK 1597
Query: 1565 IWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIA 1624
IWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++
Sbjct: 1598 IWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALS 1656
Query: 1625 LQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDDVFKRNGALLGNHVNHV 1678
LQAGLRTLHDIGPEIRRAIS DL +E E EDD+F+R G L GNHV++
Sbjct: 1657 LQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYY 1716
Query: 1679 NSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTS 1738
SD R + QT TT RPLH+ + DTE P +S +++S T
Sbjct: 1717 QSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPSSYSS------TG 1768
Query: 1739 TNANLNNANMSKAAHGKRPSIGNLEHVSENGH-----------------HSSHKHDREPQ 1781
+NAN+NNAN + RP+ + GH S+ H RE Q
Sbjct: 1769 SNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQ 1828
Query: 1782 RRSSVKRSDSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEE-CYEDDSSPTWSRQN 1840
+ + S DE D E E S+E Y+DD
Sbjct: 1829 AAMAGQEETSQDETYEVKMNHDTE---------ACSEPSLLSTEMLSYQDD--------- 1870
Query: 1841 YGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFN 1900
+ Q L ++D D R+SP+R L + + RR+SF+
Sbjct: 1871 --------------------ENRQLTLPEEDK---RDIRQSPKRGFL-RSASLGRRASFH 1906
Query: 1901 FECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATP 1960
ECL+RQ + +T LPLHL+ Q +AVAGL + +SP+ R +ATP
Sbjct: 1907 LECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATP 1961
Query: 1961 PATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPAS 2016
PATP R W P P +++E E+ +++N S PS+H SW P + R P S
Sbjct: 1962 PATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVS 2021
Query: 2017 LTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEME 2076
L VPS SA SLVEAVLISEGLG++A+DPKF+ T E+ADACD+TI+EME
Sbjct: 2022 LMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEME 2081
Query: 2077 SAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMIC 2133
SAA +L+G NG + P + +D QD G D R EE+L D +
Sbjct: 2082 SAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEELQDSRVY 2140
Query: 2134 ITTL 2137
+++L
Sbjct: 2141 VSSL 2144
>gi|193788732 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 5 [Homo sapiens]
Length = 2166
Score = 2736 bits (7092), Expect = 0.0
Identities = 1457/2184 (66%), Positives = 1657/2184 (75%), Gaps = 164/2184 (7%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN IL YFD
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPKGYFSD WN FD LIVIGSIIDV
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVI 1299
Query: 1286 LSEAD---------------------------------------NSEESNRISITFFRLF 1306
LSE + N+EE++RISITFFRLF
Sbjct: 1300 LSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLF 1359
Query: 1307 RVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNN 1366
RVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D
Sbjct: 1360 RVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTT 1419
Query: 1367 QINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEE--YTCGSNF 1424
+INRNNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK C PES+ + E CGS+F
Sbjct: 1420 EINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSF 1479
Query: 1425 AIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGR 1484
A+ YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGR
Sbjct: 1480 AVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGR 1539
Query: 1485 IKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALK 1544
IKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+
Sbjct: 1540 IKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALR 1599
Query: 1545 IKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKF 1604
IKTEGNLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKF
Sbjct: 1600 IKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKF 1659
Query: 1605 KKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKRE 1658
KKRKEQGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL +E E
Sbjct: 1660 KKRKEQGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAA 1718
Query: 1659 EEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAG 1718
EDD+F+R G L GNHV++ SD R + QT TT RPLH+ + DTE P
Sbjct: 1719 SEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLV 1777
Query: 1719 NSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGH-------- 1770
+S +++S T +NAN+NNAN + RP+ + GH
Sbjct: 1778 DST-FTPSSYSS------TGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAI 1830
Query: 1771 ---------HSSHKHDREPQRRSSVKRSDSGDEQLPTICREDPEIHGYFRDPHCLGEQEY 1821
S+ H RE Q + + S DE D E E
Sbjct: 1831 RVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTE---------ACSEPSL 1881
Query: 1822 FSSEE-CYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRR 1880
S+E Y+DD + Q L ++D D R+
Sbjct: 1882 LSTEMLSYQDD-----------------------------ENRQLTLPEEDK---RDIRQ 1909
Query: 1881 SPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGL 1940
SP+R L + + RR+SF+ ECL+RQ + +T LPLHL+ Q +AVAGL
Sbjct: 1910 SPKRGFL-RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGL 1963
Query: 1941 DSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSW 2000
+ +SP+ R +ATPPATP R W P P +++E E+ +++N S PS+H SW
Sbjct: 1964 SPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSW 2023
Query: 2001 YTDEP----DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKF 2056
P + R P SL VPS SA SLVEAVLISEGLG++A+DPKF
Sbjct: 2024 AETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKF 2083
Query: 2057 VSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDE 2116
+ T E+ADACD+TI+EMESAA +L+G NG + P + +D QD G D
Sbjct: 2084 IEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDA 2142
Query: 2117 EPDPGR---DEEDLADEMICITTL 2137
R EE+L D + +++L
Sbjct: 2143 GCVRARGRPSEEELQDSRVYVSSL 2166
>gi|193794828 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 7 [Homo sapiens]
Length = 2157
Score = 2735 bits (7090), Expect = 0.0
Identities = 1457/2175 (66%), Positives = 1657/2175 (76%), Gaps = 155/2175 (7%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN IL YFD
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPKGYFSD WN FD LIVIGSIIDV
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVI 1299
Query: 1286 LSEAD-----------NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1334
LSE + N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA
Sbjct: 1300 LSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1359
Query: 1335 LPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQ 1394
LPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATGEAWQ
Sbjct: 1360 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1419
Query: 1395 EIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1452
+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVIMDNF
Sbjct: 1420 DIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479
Query: 1453 DYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA 1512
DYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA
Sbjct: 1480 DYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA 1539
Query: 1513 CKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE-------------------GNLEQ 1553
CKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTE GNLEQ
Sbjct: 1540 CKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQ 1599
Query: 1554 ANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLV 1613
ANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLV
Sbjct: 1600 ANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLV 1659
Query: 1614 GKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDDVFKRN 1667
GK P++ ++LQAGLRTLHDIGPEIRRAIS DL +E E EDD+F+R
Sbjct: 1660 GK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRA 1718
Query: 1668 GALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHN 1727
G L GNHV++ SD R + QT TT RPLH+ + DTE P +S +
Sbjct: 1719 GGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPSS 1776
Query: 1728 HNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGH----------------- 1770
++S T +NAN+NNAN + RP+ + GH
Sbjct: 1777 YSS------TGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKL 1830
Query: 1771 HSSHKHDREPQRRSSVKRSDSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEE-CYE 1829
S+ H RE Q + + S DE D E E S+E Y+
Sbjct: 1831 SSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTE---------ACSEPSLLSTEMLSYQ 1881
Query: 1830 DDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPP 1889
DD + Q L ++D D R+SP+R L
Sbjct: 1882 DD-----------------------------ENRQLTLPEEDK---RDIRQSPKRGFL-R 1908
Query: 1890 TPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYS 1949
+ + RR+SF+ ECL+RQ + +T LPLHL+ Q +AVAGL + +S
Sbjct: 1909 SASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHS 1963
Query: 1950 PSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP---- 2005
P+ R +ATPPATP R W P P +++E E+ +++N S PS+H SW P
Sbjct: 1964 PASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGG 2023
Query: 2006 DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIA 2065
+ R P SL VPS SA SLVEAVLISEGLG++A+DPKF+ T E+A
Sbjct: 2024 SSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELA 2083
Query: 2066 DACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR--- 2122
DACD+TI+EMESAA +L+G NG + P + +D QD G D R
Sbjct: 2084 DACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRP 2142
Query: 2123 DEEDLADEMICITTL 2137
EE+L D + +++L
Sbjct: 2143 SEEELQDSRVYVSSL 2157
>gi|193788530 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 9 [Homo sapiens]
Length = 2157
Score = 2735 bits (7089), Expect = 0.0
Identities = 1453/2175 (66%), Positives = 1661/2175 (76%), Gaps = 155/2175 (7%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN ILG DY
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF DAWNTFD+LIV+GSI+D+A
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1286 LSEAD-----------NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1334
++E + N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA
Sbjct: 1300 ITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1359
Query: 1335 LPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQ 1394
LPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATGEAWQ
Sbjct: 1360 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1419
Query: 1395 EIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1452
+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVIMDNF
Sbjct: 1420 DIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479
Query: 1453 DYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA 1512
DYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA
Sbjct: 1480 DYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA 1539
Query: 1513 CKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE-------------------GNLEQ 1553
CKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTE GNLEQ
Sbjct: 1540 CKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQ 1599
Query: 1554 ANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLV 1613
ANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLV
Sbjct: 1600 ANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLV 1659
Query: 1614 GKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDDVFKRN 1667
GK P++ ++LQAGLRTLHDIGPEIRRAIS DL +E E EDD+F+R
Sbjct: 1660 GK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRA 1718
Query: 1668 GALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHN 1727
G L GNHV++ SD R + QT TT RPLH+ + DTE P +S +
Sbjct: 1719 GGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPSS 1776
Query: 1728 HNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGH----------------- 1770
++S T +NAN+NNAN + RP+ + GH
Sbjct: 1777 YSS------TGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKL 1830
Query: 1771 HSSHKHDREPQRRSSVKRSDSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEE-CYE 1829
S+ H RE Q + + S DE D E E S+E Y+
Sbjct: 1831 SSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTE---------ACSEPSLLSTEMLSYQ 1881
Query: 1830 DDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPP 1889
DD + Q L ++D D R+SP+R L
Sbjct: 1882 DD-----------------------------ENRQLTLPEEDK---RDIRQSPKRGFL-R 1908
Query: 1890 TPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYS 1949
+ + RR+SF+ ECL+RQ + +T LPLHL+ Q +AVAGL + +S
Sbjct: 1909 SASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHS 1963
Query: 1950 PSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP---- 2005
P+ R +ATPPATP R W P P +++E E+ +++N S PS+H SW P
Sbjct: 1964 PASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGG 2023
Query: 2006 DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIA 2065
+ R P SL VPS SA SLVEAVLISEGLG++A+DPKF+ T E+A
Sbjct: 2024 SSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELA 2083
Query: 2066 DACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR--- 2122
DACD+TI+EMESAA +L+G NG + P + +D QD G D R
Sbjct: 2084 DACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRP 2142
Query: 2123 DEEDLADEMICITTL 2137
EE+L D + +++L
Sbjct: 2143 SEEELQDSRVYVSSL 2157
>gi|193788528 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 8 [Homo sapiens]
Length = 2157
Score = 2734 bits (7087), Expect = 0.0
Identities = 1453/2175 (66%), Positives = 1659/2175 (76%), Gaps = 155/2175 (7%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN IL YFD
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF DAWNTFD+LIV+GSI+D+A
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1286 LSEAD-----------NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1334
++E + N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA
Sbjct: 1300 ITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1359
Query: 1335 LPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQ 1394
LPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATGEAWQ
Sbjct: 1360 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1419
Query: 1395 EIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1452
+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVIMDNF
Sbjct: 1420 DIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479
Query: 1453 DYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA 1512
DYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA
Sbjct: 1480 DYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA 1539
Query: 1513 CKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE-------------------GNLEQ 1553
CKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTE GNLEQ
Sbjct: 1540 CKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQ 1599
Query: 1554 ANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLV 1613
ANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLV
Sbjct: 1600 ANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLV 1659
Query: 1614 GKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDDVFKRN 1667
GK P++ ++LQAGLRTLHDIGPEIRRAIS DL +E E EDD+F+R
Sbjct: 1660 GK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRA 1718
Query: 1668 GALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHN 1727
G L GNHV++ SD R + QT TT RPLH+ + DTE P +S +
Sbjct: 1719 GGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPSS 1776
Query: 1728 HNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGH----------------- 1770
++S T +NAN+NNAN + RP+ + GH
Sbjct: 1777 YSS------TGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKL 1830
Query: 1771 HSSHKHDREPQRRSSVKRSDSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEE-CYE 1829
S+ H RE Q + + S DE D E E S+E Y+
Sbjct: 1831 SSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTE---------ACSEPSLLSTEMLSYQ 1881
Query: 1830 DDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPP 1889
DD + Q L ++D D R+SP+R L
Sbjct: 1882 DD-----------------------------ENRQLTLPEEDK---RDIRQSPKRGFL-R 1908
Query: 1890 TPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYS 1949
+ + RR+SF+ ECL+RQ + +T LPLHL+ Q +AVAGL + +S
Sbjct: 1909 SASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHS 1963
Query: 1950 PSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP---- 2005
P+ R +ATPPATP R W P P +++E E+ +++N S PS+H SW P
Sbjct: 1964 PASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGG 2023
Query: 2006 DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIA 2065
+ R P SL VPS SA SLVEAVLISEGLG++A+DPKF+ T E+A
Sbjct: 2024 SSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELA 2083
Query: 2066 DACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR--- 2122
DACD+TI+EMESAA +L+G NG + P + +D QD G D R
Sbjct: 2084 DACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRP 2142
Query: 2123 DEEDLADEMICITTL 2137
EE+L D + +++L
Sbjct: 2143 SEEELQDSRVYVSSL 2157
>gi|193788720 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 1 [Homo sapiens]
Length = 2221
Score = 2728 bits (7072), Expect = 0.0
Identities = 1461/2209 (66%), Positives = 1669/2209 (75%), Gaps = 159/2209 (7%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFD-- 923
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN IL YFD
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 924 ------------------YAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGV 965
Y FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV V
Sbjct: 940 FTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSV 999
Query: 966 SLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLL 1025
SL+SFGIQSSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLL
Sbjct: 1000 SLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLL 1059
Query: 1026 QFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFD 1085
QFMFACIGVQLFKGK Y C+D +K EC+G +I YKDG+VD P+++ R W+NS F+FD
Sbjct: 1060 QFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFD 1119
Query: 1086 NVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMN 1145
NVL+AMMALFTVSTFEGWP LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMN
Sbjct: 1120 NVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMN 1179
Query: 1146 IFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSS 1205
IFVGFVIVTFQEQGE+EYKNCELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+
Sbjct: 1180 IFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNST 1239
Query: 1206 PFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYF 1265
FEY+MFVLI+LNT+CLAMQHY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPKGYF
Sbjct: 1240 YFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYF 1299
Query: 1266 SDAWNTFDSLIVIGSIIDVALSEAD----------------------------------- 1290
SD WN FD LIVIGSIIDV LSE +
Sbjct: 1300 SDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQC 1359
Query: 1291 ----NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLF 1346
N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI MLF
Sbjct: 1360 SPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLF 1419
Query: 1347 FIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLC 1406
FIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK C
Sbjct: 1420 FIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKC 1479
Query: 1407 DPESDYNPGEE--YTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGP 1464
PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGP
Sbjct: 1480 APESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGP 1539
Query: 1465 HHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLN 1524
HHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPLN
Sbjct: 1540 HHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLN 1599
Query: 1525 SDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDD 1584
SDGTVMFNATLFALVRTAL+IKTEGNLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDD
Sbjct: 1600 SDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDD 1659
Query: 1585 EVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAIS 1644
EVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS
Sbjct: 1660 EVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAIS 1718
Query: 1645 CDLQDDE------PEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHV 1698
DL +E E EDD+F+R G L GNHV++ SD R + QT TT RPLH+
Sbjct: 1719 GDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHI 1778
Query: 1699 QRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPS 1758
+ DTE P +S +++S T +NAN+NNAN + RP+
Sbjct: 1779 NKAG-SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNANINNANNTALGRLPRPA 1830
Query: 1759 IGNLEHVSENGHH-----------------SSHKHDREPQRRSSVKRSDSGDEQLPTIC- 1800
G VS H SS++ P R DSG C
Sbjct: 1831 -GYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRERHVPMCEDLELRRDSGSAGTQAHCL 1889
Query: 1801 ---REDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSE-- 1855
+ +P + QE S +E YE + N+ + + +E
Sbjct: 1890 LLRKANPSRCHSRESQAAMAGQEETSQDETYE-------VKMNHDTEACSEPSLLSTEML 1942
Query: 1856 RPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPS 1915
+ + Q L ++D D R+SP+R L + + RR+SF+ ECL+RQ +
Sbjct: 1943 SYQDDENRQLTLPEEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQKDR----- 1993
Query: 1916 SPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTP 1975
+T LPLHL+ Q +AVAGL + +SP+ R +ATPPATP R W P P
Sbjct: 1994 GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVP 2053
Query: 1976 LIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSFRNKNSDKQ 2031
+++E E+ +++N S PS+H SW P + R P SL VPS
Sbjct: 2054 TLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFH 2113
Query: 2032 RSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNGNVRPRA 2091
SA SLVEAVLISEGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L+G
Sbjct: 2114 GSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSP 2173
Query: 2092 NGDVGPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2137
NG + P + +D QD G D R EE+L D + +++L
Sbjct: 2174 NGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2221
>gi|193788724 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 2 [Homo sapiens]
Length = 2186
Score = 2728 bits (7071), Expect = 0.0
Identities = 1458/2204 (66%), Positives = 1660/2204 (75%), Gaps = 184/2204 (8%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFD-- 923
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN IL YFD
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 924 ------------------YAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGV 965
Y FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV V
Sbjct: 940 FTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSV 999
Query: 966 SLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLL 1025
SL+SFGIQSSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLL
Sbjct: 1000 SLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLL 1059
Query: 1026 QFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFD 1085
QFMFACIGVQLFKGK Y C+D +K EC+G +I YKDG+VD P+++ R W+NS F+FD
Sbjct: 1060 QFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFD 1119
Query: 1086 NVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMN 1145
NVL+AMMALFTVSTFEGWP LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMN
Sbjct: 1120 NVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMN 1179
Query: 1146 IFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSS 1205
IFVGFVIVTFQEQGE+EYKNCELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+
Sbjct: 1180 IFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNST 1239
Query: 1206 PFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYF 1265
FEY+MFVLI+LNT+CLAMQHY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPKGYF
Sbjct: 1240 YFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYF 1299
Query: 1266 SDAWNTFDSLIVIGSIIDVALSEAD----------------------------------- 1290
SD WN FD LIVIGSIIDV LSE +
Sbjct: 1300 SDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQC 1359
Query: 1291 ----NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLF 1346
N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI MLF
Sbjct: 1360 SPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLF 1419
Query: 1347 FIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLC 1406
FIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK C
Sbjct: 1420 FIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKC 1479
Query: 1407 DPESDYNPGEE--YTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGP 1464
PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGP
Sbjct: 1480 APESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGP 1539
Query: 1465 HHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLN 1524
HHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPLN
Sbjct: 1540 HHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLN 1599
Query: 1525 SDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDD 1584
SDGTVMFNATLFALVRTAL+IKTEGNLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDD
Sbjct: 1600 SDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDD 1659
Query: 1585 EVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAIS 1644
EVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS
Sbjct: 1660 EVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAIS 1718
Query: 1645 CDLQDDE------PEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHV 1698
DL +E E EDD+F+R G L GNHV++ SD R + QT TT RPLH+
Sbjct: 1719 GDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHI 1778
Query: 1699 QRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPS 1758
+ DTE P +S +++S T +NAN+NNAN + RP+
Sbjct: 1779 NKAG-SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNANINNANNTALGRLPRPA 1830
Query: 1759 IGNLEHVSENGH-----------------HSSHKHDREPQRRSSVKRSDSGDEQLPTICR 1801
+ GH S+ H RE Q + + S DE
Sbjct: 1831 GYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMN 1890
Query: 1802 EDPEIHGYFRDPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGY 1860
D E E S+E Y+DD
Sbjct: 1891 HDTE---------ACSEPSLLSTEMLSYQDD----------------------------- 1912
Query: 1861 HHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFP 1920
+ Q L ++D D R+SP+R L + + RR+SF+ ECL+RQ +
Sbjct: 1913 ENRQLTLPEEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQKDR-----GGDIS 1963
Query: 1921 HRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVE 1980
+T LPLHL+ Q +AVAGL + +SP+ R +ATPPATP R W P P +++E
Sbjct: 1964 QKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLE 2023
Query: 1981 QSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSFRNKNSDKQRSADS 2036
E+ +++N S PS+H SW P + R P SL VPS SA S
Sbjct: 2024 GVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASS 2083
Query: 2037 LVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVG 2096
LVEAVLISEGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L+G NG +
Sbjct: 2084 LVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGALL 2143
Query: 2097 PLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2137
P + +D QD G D R EE+L D + +++L
Sbjct: 2144 PFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2186
>gi|193788728 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 3 [Homo sapiens]
Length = 2179
Score = 2726 bits (7065), Expect = 0.0
Identities = 1453/2197 (66%), Positives = 1659/2197 (75%), Gaps = 177/2197 (8%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+NDA+G + PW+YFV+L+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSV 523
PTSETESVNTENV+G EGEN C L ISKSK SR WRRWNRF RR+CRAAVKS
Sbjct: 467 PTSETESVNTENVAGGDIEGEN--CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 524 TFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 583
FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLALFT EML+KMYSLGLQAYF
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 584 VSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
VSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLRIFK+TR+W SLSNLVASL
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILT 703
LNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+RSTFDNFPQ+LLTVFQILT
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILT 704
Query: 704 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
GEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLNVFLAIAVDNLADAESL +
Sbjct: 705 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
Query: 764 AQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD---------------NKVTID 806
AQKEE EEKERKK+AR S E K+ KP V + K+ +D
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMD 824
Query: 807 DYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSA 865
D + E+EDK PYP E EE+E+EPE+P GPRPR +SEL++KEK P+PE SA
Sbjct: 825 DLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 866 FFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYA 925
FFI S N R+ CH+++N IFTNLIL FI+LSS +LAAEDP++ SFRN IL YFD
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 926 FTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRV 985
FT IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRV
Sbjct: 940 FTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRV 999
Query: 986 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCT 1045
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+
Sbjct: 1000 LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS 1059
Query: 1046 DEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPA 1105
D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP
Sbjct: 1060 DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE 1119
Query: 1106 LLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKN 1165
LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKN
Sbjct: 1120 LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1179
Query: 1166 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ 1225
CELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQ
Sbjct: 1180 CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1226 HYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVA 1285
HY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF DAWNTFD+LIV+GSI+D+A
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1286 LSEAD---------------------------------NSEESNRISITFFRLFRVMRLV 1312
++E + N+EE++RISITFFRLFRVMRLV
Sbjct: 1300 ITEVNPAEHTQCSPSMGPSCSHPPLAVLTAPPVADGFQNAEENSRISITFFRLFRVMRLV 1359
Query: 1313 KLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNN 1372
KLLSRGEGIRTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNN
Sbjct: 1360 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1419
Query: 1373 NFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFI 1430
NFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK C PES+ + E CGS+FA+ YFI
Sbjct: 1420 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFI 1479
Query: 1431 SFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDV 1490
SFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDV
Sbjct: 1480 SFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDV 1539
Query: 1491 VTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE-- 1548
VTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTE
Sbjct: 1540 VTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEG 1599
Query: 1549 -----------------GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKF 1591
GNLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKF
Sbjct: 1600 PSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKF 1659
Query: 1592 YATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDE 1651
YATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL +E
Sbjct: 1660 YATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEE 1718
Query: 1652 ------PEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPP 1705
E EDD+F+R G L GNHV++ SD R + QT TT RPLH+ +
Sbjct: 1719 ELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG-SS 1777
Query: 1706 ASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHV 1765
DTE P +S +++S T +NAN+NNAN + RP+
Sbjct: 1778 QGDTESPSHEKLVDST-FTPSSYSS------TGSNANINNANNTALGRLPRPAGYPSTVS 1830
Query: 1766 SENGH-----------------HSSHKHDREPQRRSSVKRSDSGDEQLPTICREDPEIHG 1808
+ GH S+ H RE Q + + S DE D E
Sbjct: 1831 TVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTE--- 1887
Query: 1809 YFRDPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFL 1867
E S+E Y+DD + Q L
Sbjct: 1888 ------ACSEPSLLSTEMLSYQDD-----------------------------ENRQLTL 1912
Query: 1868 EDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPL 1927
++D D R+SP+R L + + RR+SF+ ECL+RQ + +T LPL
Sbjct: 1913 PEEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPL 1963
Query: 1928 HLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQ 1987
HL+ Q +AVAGL + +SP+ R +ATPPATP R W P P +++E E+ ++
Sbjct: 1964 HLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEK 2023
Query: 1988 VNGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLI 2043
+N S PS+H SW P + R P SL VPS SA SLVEAVLI
Sbjct: 2024 LNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLI 2083
Query: 2044 SEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQD 2103
SEGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L+G NG + P + +D
Sbjct: 2084 SEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRD 2143
Query: 2104 YELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2137
QD G D R EE+L D + +++L
Sbjct: 2144 AG-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2179
>gi|53832007 calcium channel, voltage-dependent, L type, alpha 1F
subunit [Homo sapiens]
Length = 1977
Score = 2397 bits (6213), Expect = 0.0
Identities = 1202/1628 (73%), Positives = 1357/1628 (83%), Gaps = 70/1628 (4%)
Query: 83 RKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVA 142
++R Q++K K +S R RALFCL+L NP+RR+CISIVEWKPFDI ILL IFANCVA
Sbjct: 49 KRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVA 108
Query: 143 LAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDF 202
L +YIPFPEDDSN+ NHNLE+VEY FL+IFTVET LKI+AYGL+LHP+AY+RNGWNLLDF
Sbjct: 109 LGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDF 168
Query: 203 VIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLN 262
+IV+VGLFSV+LEQ H+ GK GGFDVKALRAFRVLRPLRLVSGVPSL +VLN
Sbjct: 169 IIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLN 228
Query: 263 SIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGN 322
SI+KA+VPLLHIALLVLFVIIIYAIIGLELF+G+MHKTC+F SD+ AEEDP+PCA SG+
Sbjct: 229 SIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGS 288
Query: 323 GRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELP 382
GR CT N TECR W GPNGGITNFDNF FAMLTVFQC+TMEGWTDVLYWM DAMG+ELP
Sbjct: 289 GRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELP 348
Query: 383 WVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWI 442
WVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQK REKQQ+EEDL+GYLDWI
Sbjct: 349 WVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWI 408
Query: 443 TQAEDIDPENEE---------EGGEEGKR-----------------------------NT 464
TQAE++D E+ E G G R +
Sbjct: 409 TQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRSTHSTSSHA 468
Query: 465 SMPTSETESVNTENVSGEGENRGC---CGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVK 521
S+P S+T S+ TE E E G C I K+++ RR RR NR R RCR AVK
Sbjct: 469 SLPASDTGSM-TETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRARCRRAVK 527
Query: 522 SVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQA 581
S YW V++LVFLNTLTI+SEH+ QP WLTQIQ+ ANKVLL LFT EML+K+Y LG A
Sbjct: 528 SNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSA 587
Query: 582 YFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVA 641
Y S FNRFDCFVVCGGI ET LVE+ M PLGISV RCVRLLRIFKVTRHW SLSNLVA
Sbjct: 588 YVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVA 647
Query: 642 SLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQI 701
SLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD+T TKRSTFD FPQALLTVFQI
Sbjct: 648 SLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQALLTVFQI 707
Query: 702 LTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESL 761
LTGEDWN VMYDGIMAYGGP GM+VCIYFIILFICGNYILLNVFLAIAVDNLA ++
Sbjct: 708 LTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDA- 766
Query: 762 NTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPC 821
TA+ + E+ K + + +N+ + +E+E+
Sbjct: 767 GTAKDKGGEKSNEKDLPQ--------------------ENEGLVPGVEKEEEEGARREGA 806
Query: 822 DVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHK 881
D+ EEEEEEEE+E E + E+ KEK+ PIPEGSAFF LS+TNP+R GCH
Sbjct: 807 DMEEEEEEEEEEEEEEEEEGAGGVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHT 866
Query: 882 LINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTF 941
LI+HH+FTNLILVFI+LSS +LAAEDPIR+HSFRN ILGYFDYAFT+IFTVEILLKMT F
Sbjct: 867 LIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVF 926
Query: 942 GAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGL 1001
GAFLH+G+FCR++FN+LD+LVV VSL+SFGI SSAISVVKILRVLRVLRPLRAINRAKGL
Sbjct: 927 GAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVKILRVLRVLRPLRAINRAKGL 986
Query: 1002 KHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFIL 1061
KHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY CTDEAK P+EC+G F++
Sbjct: 987 KHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLV 1046
Query: 1062 YKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPI 1121
Y DGDV P+VRER+W NSDFNFDNVLSAMMALFTVSTFEGWPALLYKAID+ E+ GPI
Sbjct: 1047 YPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPI 1106
Query: 1122 YNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALK 1181
YN+RVEIS+FFI+YIII+AFFMMNIFVGFVI+TF+ QGE+EY+NCELDKNQRQCVEYALK
Sbjct: 1107 YNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALK 1166
Query: 1182 ARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILN 1241
A+PLRRYIPKNP+QY+ W VNS+ FEY+MF+LI+LNT+ LAMQHYEQ+ FN AMDILN
Sbjct: 1167 AQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILN 1226
Query: 1242 MVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADN-------SEE 1294
MVFTG+FT+EMVLK+IAFKPK YF+DAWNTFD+LIV+GSI+D+A++E +N SE+
Sbjct: 1227 MVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSED 1286
Query: 1295 SNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGM 1354
S+RISITFFRLFRVMRLVKLLS+GEGIRTLLWTFIKSFQALPYVALLIAM+FFIYAVIGM
Sbjct: 1287 SSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGM 1346
Query: 1355 QMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNP 1414
QMFGKVA++D QINRNNNFQTFPQAVLLLFRCATGEAWQEIMLA LPG CDPESD+ P
Sbjct: 1347 QMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGP 1406
Query: 1415 GEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW 1474
GEE+TCGSNFAI YFISF+MLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW
Sbjct: 1407 GEEFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW 1466
Query: 1475 SEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNAT 1534
SEYDP AKGRIKHLDVV LLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTV FNAT
Sbjct: 1467 SEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVTFNAT 1526
Query: 1535 LFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYAT 1594
LFALVRT+LKIKTEGNLEQAN+ELR VIKKIWK+ KLLD+V+PP ++EVTVGKFYAT
Sbjct: 1527 LFALVRTSLKIKTEGNLEQANQELRIVIKKIWKRMKQKLLDEVIPPPDEEEVTVGKFYAT 1586
Query: 1595 FLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEE 1654
FLIQDYFRKF++RKE+GL+G A +T+ ALQAGLR+L D+GPE+R+A++CD +++E E
Sbjct: 1587 FLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAGLRSLQDLGPEMRQALTCDTEEEEEEG 1646
Query: 1655 TKREEEDD 1662
+ EE+D
Sbjct: 1647 QEGVEEED 1654
Score = 135 bits (340), Expect = 4e-31
Identities = 105/262 (40%), Positives = 128/262 (48%), Gaps = 67/262 (25%)
Query: 1877 DSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMA 1936
D PRRRLLPPTPA R+ SF +CL+RQ S E++P + HR
Sbjct: 1782 DGHLVPRRRLLPPTPAG-RKPSFTIQCLQRQGSCEDLPIPGTY-HR-------------- 1825
Query: 1937 VAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLH 1996
+ P+ + SWATPP Y PL+ VE+ A + G
Sbjct: 1826 --------GRNSGPNRAQGSWATPPQRGRL-----LYAPLLLVEEGAAGEGYLG------ 1866
Query: 1997 RSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKF 2056
RSS RTFT L VP + + + K+ SADSLVEAVLISEGLG +ARDP+F
Sbjct: 1867 RSSG-------PLRTFT--CLHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARDPRF 1917
Query: 2057 VSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDE 2116
V+ K EIADAC LT+DEM++AAS LL Q YSDE
Sbjct: 1918 VALAKQEIADACRLTLDEMDNAASDLL----------------------AQGTSSLYSDE 1955
Query: 2117 EPDPGR-DEEDLADEMICITTL 2137
E R DEEDL DEM C+ L
Sbjct: 1956 ESILSRFDEEDLGDEMACVHAL 1977
>gi|110349767 calcium channel, voltage-dependent, L type, alpha 1S
subunit [Homo sapiens]
Length = 1873
Score = 2266 bits (5872), Expect = 0.0
Identities = 1158/1730 (66%), Positives = 1366/1730 (78%), Gaps = 84/1730 (4%)
Query: 69 MSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPF 128
M S+P G RK+Q KK RP RALFCL+L NP+R+ACISIVEWKPF
Sbjct: 1 MEPSSPQDEGL---RKKQP----KKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPF 53
Query: 129 DIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLH 188
+ ILL IFANCVALA+Y+P PEDD+NS N LEK+EY FLI+F++E +KIIAYG L H
Sbjct: 54 ETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFH 113
Query: 189 PNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPL 248
+AY+R+GWN+LDF IV +G+F+VILEQ+ S K G DVKALRAFRVLRPL
Sbjct: 114 QDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPL 173
Query: 249 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDI 308
RLVSGVPSLQVVLNSI KAM+PL HIALLVLF++IIYAIIGLELF GKMHKTC+F +DI
Sbjct: 174 RLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDI 233
Query: 309 VA---EEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEG 365
VA E+P+PCA +G+GR+CT NG+ECR GW GPN GIT+FDNF F+MLTV+QCITMEG
Sbjct: 234 VATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEG 293
Query: 366 WTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 425
WTDVLYW+NDA+G E PW+YFV+L++ GSFF+LNLVLGVLSGEF+KEREKAK+RG FQKL
Sbjct: 294 WTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKL 353
Query: 426 REKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVSGEGEN 485
REKQQL+EDL+GY+ WITQ E +D E+ EG K + S+TES+ ++G
Sbjct: 354 REKQQLDEDLRGYMSWITQGEVMDVEDFREG----KLSLDEGGSDTESLY--EIAG---- 403
Query: 486 RGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHY 545
+ Q I R WR+WNR R +C VKS FYWLVI++V LNTL+I+SEH+
Sbjct: 404 ---LNKIIQFI------RHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHH 454
Query: 546 NQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILV 605
NQP WLT++QDIAN+VLL+LFT EML+KMY LGL+ YF+S+FNRFDCFVVC GI E +LV
Sbjct: 455 NQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLV 514
Query: 606 ELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFS 665
E M+PLGISV RC+RLLRIFK+T++WTSLSNLVASLLNS++SIASLLLLLFLFI+IF+
Sbjct: 515 ESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFA 574
Query: 666 LLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSG 725
LLGMQLFGG+++F++T+ +RS FDNFPQAL++VFQ+LTGEDW ++MY+GIMAYGGPS G
Sbjct: 575 LLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPG 634
Query: 726 MIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIAR------ 779
M+VCIYFIILF+CGNYILLNVFLAIAVDNLA+AESL +AQK +AEEK+R+K+++
Sbjct: 635 MLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSKGLPDKS 694
Query: 780 ---KESLENKKNNKPEVNQIANSDNKVTIDDYREE-DEDKDPYPPCDVPVGEEEEEEEED 835
K ++ K KP+ I + K+ ID++ +E KDPYP D P ++EED
Sbjct: 695 EEEKSTMAKKLEQKPKGEGIPTTA-KLKIDEFESNVNEVKDPYPSADFP-----GDDEED 748
Query: 836 EPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVF 895
EPE+P PRPR ++EL +KEK PIPE S+FFI S TN IRV CH+++N FTN IL+F
Sbjct: 749 EPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLF 808
Query: 896 IMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYF 955
I+LSSAALAAEDPIR+ S RN IL +FD FT++FTVEI+LKMTT+GAFLHKG+FCRNYF
Sbjct: 809 ILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYF 868
Query: 956 NLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 1015
N+LD+LVV VSL+S G++SSAISVVKILRVLRVLRPLRAINRAKGLKHVVQC+FVAI TI
Sbjct: 869 NMLDLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTI 928
Query: 1016 GNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRER 1075
GNI++VTTLLQFMFACIGVQLFKGKF+RCTD +K EECRG + +YKDGD +R R
Sbjct: 929 GNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHR 988
Query: 1076 IWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIY 1135
W +SDF+FDNVLSAMM+LFTVSTFEGWP LLYKAIDSN E++GPIYN+RVE++IFFIIY
Sbjct: 989 EWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIY 1048
Query: 1136 IIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQ 1195
II++AFFMMNIFVGFVIVTFQEQGE EYKNCELDKNQRQCV+YALKARPLR YIPKNPYQ
Sbjct: 1049 IILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQ 1108
Query: 1196 YKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLK 1255
Y+ WY+V SS FEY+MF LIMLNT+CL MQHY QS+ N DILN+ FT +FT+EM+LK
Sbjct: 1109 YQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILK 1168
Query: 1256 VIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEAD-------------------NSEESN 1296
++AFK +GYF D WN FD LIVIGSIIDV LSE D + +ES
Sbjct: 1169 LMAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESA 1228
Query: 1297 RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQM 1356
RIS FFRLFRVMRL+KLLSR EG+RTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQM
Sbjct: 1229 RISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQM 1288
Query: 1357 FGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE 1416
FGK+A+ D QINRNNNFQTFPQAVLLLFRCATGEAWQEI+LAC GKLCDPESDY PGE
Sbjct: 1289 FGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGE 1348
Query: 1417 EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSE 1476
EYTCG+NFA YFISFYMLCAFL+INLFVAVIMDNFDYLTRDWSILGPHHLDEFK IW+E
Sbjct: 1349 EYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAE 1408
Query: 1477 YDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLF 1536
YDPEAKGRIKHLDVVTLLRRIQPPLGFGK CPHRVACKRLV MNMPLNSDGTV FNATLF
Sbjct: 1409 YDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLF 1468
Query: 1537 ALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFL 1596
ALVRTALKIKTEGN EQANEELRA+IKKIWK+TSMKLLDQV+PP GDDEVTVGKFYATFL
Sbjct: 1469 ALVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFL 1528
Query: 1597 IQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTL-HDIGPEIRRAISCDLQDDEPEET 1655
IQ++FRKF KR+E+ Y K + +QAGLRT+ + PEI R +S DL +E E
Sbjct: 1529 IQEHFRKFMKRQEE--YYGYRPKKDIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEELER 1586
Query: 1656 KREE---EDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKP 1712
E E+ +F+R G L G N + +R +SL RPL + + E P
Sbjct: 1587 AMVEAAMEEGIFRRTGGLFGQVDNFL--ERTNSLPPVMANQRPLQFAEIEM---EEMESP 1641
Query: 1713 LF------PPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKR 1756
+F P N + N N+ V N+N +N+++ + H +R
Sbjct: 1642 VFLEDFPQDPRTNPLA--RANTNNANANVAYG-NSNHSNSHVFSSVHYER 1688
Score = 47.0 bits (110), Expect = 2e-04
Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 5/85 (5%)
Query: 2010 RTFTPASL--TVPSSFRNKNSDKQRSADS---LVEAVLISEGLGRYARDPKFVSATKHEI 2064
++ TP SL P S + + + SA + L++ L+ GLG A D F+ AT +
Sbjct: 1755 KSSTPGSLHEETPHSRSTRENTSRCSAPATALLIQKALVRGGLGTLAADANFIMATGQAL 1814
Query: 2065 ADACDLTIDEMESAASTLLNGNVRP 2089
ADAC + +E+E A+ LL G P
Sbjct: 1815 ADACQMEPEEVEIMATELLKGREAP 1839
>gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo
sapiens]
Length = 2261
Score = 781 bits (2016), Expect = 0.0
Identities = 398/810 (49%), Positives = 551/810 (68%), Gaps = 41/810 (5%)
Query: 820 PCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGC 879
P +P EEE++EEE++ GP+P +P S+ FILS TNP+R C
Sbjct: 1192 PDPLPKKEEEKKEEEEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLC 1237
Query: 880 HKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMT 939
H ++N F IL+ I +SS ALAAEDP++ ++ RN +L YFDY FT +FT E+++KM
Sbjct: 1238 HYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMI 1297
Query: 940 TFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSA----ISVVKILRVLRVLRPLRAI 995
G LH+GA+ R+ +N+LD +VV +LV+F ++ I+ +K LRVLRVLRPL+ I
Sbjct: 1298 DLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTI 1357
Query: 996 NRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEEC 1055
R LK V CV +++ + NI+IV L F+FA + VQLFKGKF+ CTDE+K ++C
Sbjct: 1358 KRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC 1417
Query: 1056 RGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNG 1115
RG ++LY+ +V + R+R W+ +F++DNVL A++ LFTVST EGWP +L ++D+
Sbjct: 1418 RGKYLLYEKNEVKA---RDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
Query: 1116 ENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQC 1175
EN GP +R+E+SIF+++Y ++ FF +NIFV +I+TFQEQG+K + L+KN+R C
Sbjct: 1475 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERAC 1534
Query: 1176 VEYALKARPLRRYIPKNP--YQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMF 1233
+++A+ A+PL R++P+N +QY+ W V S PFEY + +I LNT+ L M+ Y S +
Sbjct: 1535 IDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAY 1594
Query: 1234 NDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSE 1293
+A+ + N+VFT +F++E VLKV+AF YF DAWN FD + V+GSI D+ ++E N
Sbjct: 1595 ENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGN-- 1652
Query: 1294 ESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIG 1353
N I+++F RLFR RL+KLL +G IR LLWTF++SF+ALPYV LLIAMLFFIYA+IG
Sbjct: 1653 --NFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1710
Query: 1354 MQMFGKVAM--------RDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL 1405
MQ+FG + + D QI +NNF+TF QA++LLFR ATGEAW IML+CL GK
Sbjct: 1711 MQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKP 1770
Query: 1406 CDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH 1465
CD S E CG+ FA YF+SF LC+FL++NLFVAVIMDNF+YLTRD SILGPH
Sbjct: 1771 CDKNSGILTRE---CGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPH 1827
Query: 1466 HLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS 1525
HLDE+ R+W+EYDP A GRI + D+ +LLR I PPLG GK CPHRVACKRL+ M++P+
Sbjct: 1828 HLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVAD 1887
Query: 1526 DGTVMFNATLFALVRTALKIKTE---GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAG 1582
D TV FN+TL AL+RTAL IK + +Q + ELR + IW S K LD +V P
Sbjct: 1888 DNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHK 1947
Query: 1583 DDEVTVGKFYATFLIQDYFRKFKKRKEQGL 1612
++TVGK YA +I +Y+R+ K +K Q +
Sbjct: 1948 STDLTVGKIYAAMMIMEYYRQSKAKKLQAM 1977
Score = 654 bits (1686), Expect = 0.0
Identities = 354/724 (48%), Positives = 470/724 (64%), Gaps = 39/724 (5%)
Query: 104 RALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEK 163
R+LF S +N +R+ I EW PF+ IL I ANC+ LA+ P+DD + L+
Sbjct: 76 RSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDD 135
Query: 164 VEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEG 223
E F+ IF E +KIIA G H +Y+RNGWN++DFV+V+ G+ + + +
Sbjct: 136 TEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------- 188
Query: 224 GNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 283
FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAM+PLL I LL+ F I+
Sbjct: 189 ----------FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAIL 238
Query: 284 IYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGG 343
I+AIIGLE ++GK H TCF +D + E PAPC R C NGT+C+ W GPN G
Sbjct: 239 IFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCP-NGTKCQPYWEGPNNG 297
Query: 344 ITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLG 403
IT FDN FA+LTVFQCITMEGWTD+LY NDA G W+YF+ L+I GSFF+LNLVLG
Sbjct: 298 ITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLG 357
Query: 404 VLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEE---- 459
VLSGEF+KERE+ + R F KLR +QQ+E +L GY++WI++AE++ +E GE+
Sbjct: 358 VLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPF 417
Query: 460 --GKRNTSMPTSETESVNTENVSGEGENRGCCGS--LCQAISKSKL--SRRWRRWNRFNR 513
R T++ S+T+ +N E + + GS +I +KL S + + R R
Sbjct: 418 DGALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMR 477
Query: 514 RRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVK 573
R VK+ FYW V+ LV LNTL ++ HYNQP+WL+ A + L LF EM +K
Sbjct: 478 FYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIK 537
Query: 574 MYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHW 633
MY LG + YF S FN FDC V+ G I E I ++ + GISV R +RLLRIFKVT++W
Sbjct: 538 MYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYW 597
Query: 634 TSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQ 693
SL NLV SLLNSMKSI SLL LLFLFI++F+LLGMQLFGG+FNFDE T + FD FP
Sbjct: 598 ASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDE-GTPPTNFDTFPA 656
Query: 694 ALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVD 753
A++TVFQILTGEDWN VMYDGI + GG GM+ IYFI+L + GNY LLNVFLAIAVD
Sbjct: 657 AIMTVFQILTGEDWNEVMYDGIKSQGG-VQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVD 715
Query: 754 NLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDE 813
NLA+A+ L T ++E EE +K+A +++ E EV+ ++ ++ + + +E+ +
Sbjct: 716 NLANAQEL-TKDEQEEEEAANQKLALQKAKE-----VAEVSPLSAANMSIAV---KEQQK 766
Query: 814 DKDP 817
++ P
Sbjct: 767 NQKP 770
Score = 217 bits (552), Expect = 1e-55
Identities = 180/719 (25%), Positives = 329/719 (45%), Gaps = 121/719 (16%)
Query: 67 QTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWK 126
Q + P P+ + K+++ + + P ++F LS NP+RR C I+ +
Sbjct: 1185 QVNKNANPDPLPKKEEEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLR 1244
Query: 127 PFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLL 186
F++ IL+ I + +ALA P + N+ L +Y F +FT E +K+I GL+
Sbjct: 1245 YFEMCILMVIAMSSIALAAEDPVQPNAPR--NNVLRYFDYVFTGVFTFEMVIKMIDLGLV 1302
Query: 187 LHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFD---VKALRAFR 243
LH AY R+ WN+LDF++V L + +G S G D +K+LR R
Sbjct: 1303 LHQGAYFRDLWNILDFIVVSGALVAFAF-------------TGNSKGKDINTIKSLRVLR 1349
Query: 244 VLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFF 303
VLRPL+ + +P L+ V + ++ ++ + +I ++ + + I+A++ ++LF GK FF
Sbjct: 1350 VLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGK-----FF 1404
Query: 304 ADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITM 363
+D ++E C G+ E ++ ++DN +A+LT+F T
Sbjct: 1405 HCTD-ESKEFEKDC----RGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTG 1459
Query: 364 EGWTDVLYWMNDA----------MGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKER 413
EGW VL DA E+ Y V V+F FFV N+ + ++ F ++
Sbjct: 1460 EGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFV-NIFVALIIITFQEQ- 1517
Query: 414 EKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETES 473
GD K+ E+ LE++ + +D+ A+
Sbjct: 1518 ------GD--KMMEEYSLEKNERACIDFAISAK--------------------------- 1542
Query: 474 VNTENVSGEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLV 533
L + + ++K S ++R W V S F + ++ ++
Sbjct: 1543 -----------------PLTRHMPQNKQSFQYRMWQ---------FVVSPPFEYTIMAMI 1576
Query: 534 FLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCF 593
LNT+ + + Y + N V +LF+ E ++K+ + G+ YF +N FD
Sbjct: 1577 ALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFV 1636
Query: 594 VVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASL 653
V G IT+ ++ E + + +S R R R+ K+ R ++ L+ + + S K++ +
Sbjct: 1637 TVLGSITDILVTEFG-NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1695
Query: 654 LLLLFLFIIIFSLLGMQLFGG--------KFNFDETQ-TKRSTFDNFPQALLTVFQILTG 704
LL+ + I++++GMQ+FG + DE Q T+ + F F QAL+ +F+ TG
Sbjct: 1696 CLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATG 1755
Query: 705 EDWNAVMYDGIMAYGGPSSSGMI--------VCIYFI-ILFICGNYILLNVFLAIAVDN 754
E W+ +M + +SG++ YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 1756 EAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
Score = 191 bits (484), Expect = 9e-48
Identities = 167/691 (24%), Positives = 296/691 (42%), Gaps = 138/691 (19%)
Query: 865 AFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAED--PIRSHSFRNTILGYF 922
+ F+ S+ N +R K+ F +IL I+ + LA E P + + L
Sbjct: 77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
Query: 923 DYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVS-LVSFGIQSSAISVVK 981
+ F IF E +K+ G HKG++ RN +N++D +VV L + G + ++
Sbjct: 137 EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
Query: 982 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1041
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ +FA IG++ + GKF
Sbjct: 193 TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
Query: 1042 YR-CTDEAKSNPEECRGLFILYKDGDVDSPVVRER-------------IWQ---NSDFNF 1084
+ C +E + + G+ +P E W+ N F
Sbjct: 253 HTTCFEEGTDDIQ-----------GESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQF 301
Query: 1085 DNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMM 1144
DN+L A++ +F T EGW LLY + D++G +Y FI III +FFM+
Sbjct: 302 DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLY---------FIPLIIIGSFFML 352
Query: 1145 NIFVG------------------FVIVTFQEQGEKEYKNC---------------ELDKN 1171
N+ +G F+ + Q+Q E+E E D
Sbjct: 353 NLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGE 412
Query: 1172 QRQCVEYALKARPLRR---------------------------------------YIPKN 1192
QR + AL+ +++ + K
Sbjct: 413 QRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKK 472
Query: 1193 PYQYKFWY--VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTV 1250
+ +F+ +V + F + + L+ LNTLC+A+ HY Q + +D + +F G+F
Sbjct: 473 ERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMS 532
Query: 1251 EMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMR 1310
EM +K+ + YF ++N FD ++IGSI +V + + I+ R R++R
Sbjct: 533 EMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVI---KPGTSFGISVLRALRLLR 589
Query: 1311 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINR 1370
+ K+ +R L+ + + S +++ + L+ + ++A++GMQ+FG D
Sbjct: 590 IFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEG--TP 647
Query: 1371 NNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFI 1430
NF TFP A++ +F+ TGE W E+M D + G +YFI
Sbjct: 648 PTNFDTFPAAIMTVFQILTGEDWNEVMY------------DGIKSQGGVQGGMVFSIYFI 695
Query: 1431 SFYMLCAFLIINLFVAVIMDNF---DYLTRD 1458
+ + ++N+F+A+ +DN LT+D
Sbjct: 696 VLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
Score = 139 bits (349), Expect = 4e-32
Identities = 177/787 (22%), Positives = 321/787 (40%), Gaps = 169/787 (21%)
Query: 479 VSGEGENRGCCGSL------CQAISKSKLSRRWRRWNRFN----RRRC------------ 516
V G G RG GS Q + K +++R R +N R+ C
Sbjct: 24 VVGSGGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSE 83
Query: 517 ----RAAVKSVT----FYWLVIVLVFLNTLTISSEHYNQPDWLTQIQ---DIANKVLLAL 565
R K +T F ++++ + N + ++ E + D T + D + +
Sbjct: 84 DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 143
Query: 566 FTCEMLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCV 621
F E +K+ +LG +Y + +N D VV GI T+ E ++ + R V
Sbjct: 144 FCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT------LRAV 197
Query: 622 RLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFN---F 678
R+LR K+ SL ++ S++ +M + + LLLF I+IF+++G++ + GKF+ F
Sbjct: 198 RVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF 257
Query: 679 DE--------------TQTKRST--------------------FDNFPQALLTVFQILTG 704
+E T+ T FDN A+LTVFQ +T
Sbjct: 258 EEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITM 317
Query: 705 EDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTA 764
E W ++Y+ A G + +YFI L I G++ +LN+ L + A
Sbjct: 318 EGWTDLLYNSNDASGNTWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEFAK------- 365
Query: 765 QKEEAEEKER-KKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPC-- 821
++E E + K+ R++ +E + N E I+ ++ + +D + E + P+
Sbjct: 366 ERERVENRRAFLKLRRQQQIERELNGYME--WISKAEEVILAED-ETDGEQRHPFDGALR 422
Query: 822 ---------DVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKT 872
D+ EE E++ D V + I + E S FF K
Sbjct: 423 RTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKL--------ENSTFFH-KKE 473
Query: 873 NPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTV 932
+R +++ F +L + L++ +A + + L Y ++ F +F
Sbjct: 474 RRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH-YNQPEWLSDFLYYAEFIFLGLFMS 532
Query: 933 EILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSL--VSFGIQSSAISV-VKILRVLRVL 989
E+ +KM G + + FN D V+ S+ V + + S + +LR LR+L
Sbjct: 533 EMFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLL 588
Query: 990 RPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAK 1049
R + L+++V + ++++I +++ + L +FA +G+QLF G+F
Sbjct: 589 RIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF-------- 640
Query: 1050 SNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYK 1109
+ D +P NFD +A+M +F + T E W ++Y
Sbjct: 641 --------------NFDEGTPPT----------NFDTFPAAIMTVFQILTGEDWNEVMYD 676
Query: 1110 AIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVI--------VTFQEQGEK 1161
I S G G + SI+FI+ + + ++N+F+ + +T EQ E+
Sbjct: 677 GIKSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEE 731
Query: 1162 EYKNCEL 1168
E N +L
Sbjct: 732 EAANQKL 738
Score = 80.9 bits (198), Expect = 1e-14
Identities = 74/296 (25%), Positives = 131/296 (44%), Gaps = 61/296 (20%)
Query: 127 PFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLL 186
PF+ I+ I N + L + S + + L F +F++E LK++A+G+L
Sbjct: 1567 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1623
Query: 187 LHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLR 246
Y R+ WN+ DFV V+ + +++ TE GN+ ++ LR FR R
Sbjct: 1624 ----NYFRDAWNIFDFVTVLGSITDILV------TEFGNNF------INLSFLRLFRAAR 1667
Query: 247 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADS 306
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F G + DS
Sbjct: 1668 LIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-GNIGIDVEDEDS 1726
Query: 307 DIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGW 366
D ED Q T + NF F A++ +F+ T E W
Sbjct: 1727 D----EDEF---------QITEHN---------------NFRTFFQALMLLFRSATGEAW 1758
Query: 367 TDVLYW-------------MNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 409
+++ + G E + YFVS + SF +LNL + V+ F
Sbjct: 1759 HNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
>gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo
sapiens]
Length = 2506
Score = 772 bits (1994), Expect = 0.0
Identities = 394/810 (48%), Positives = 549/810 (67%), Gaps = 41/810 (5%)
Query: 820 PCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGC 879
P +P EEE++EEE++ GP+P +P S+ FILS TNP+R C
Sbjct: 1191 PDPLPKKEEEKKEEEEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLC 1236
Query: 880 HKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMT 939
H ++N F IL+ I +SS ALAAEDP++ ++ RN +L YFDY FT +FT E+++KM
Sbjct: 1237 HYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMI 1296
Query: 940 TFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSA----ISVVKILRVLRVLRPLRAI 995
G LH+GA+ R+ +N+LD +VV +LV+F ++ I+ +K LRVLRVLRPL+ I
Sbjct: 1297 DLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTI 1356
Query: 996 NRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEEC 1055
R LK V CV +++ + NI+IV L F+FA + VQLFKGKF+ CTDE+K ++C
Sbjct: 1357 KRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC 1416
Query: 1056 RGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNG 1115
RG ++LY+ +V + R+R W+ +F++DNVL A++ LFTVST EGWP +L ++D+
Sbjct: 1417 RGKYLLYEKNEVKA---RDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1473
Query: 1116 ENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQC 1175
EN GP +R+E+SIF+++Y ++ FF +NIFV +I+TFQEQG+K + L+KN+R C
Sbjct: 1474 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERAC 1533
Query: 1176 VEYALKARPLRRYIPKNP--YQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMF 1233
+++A+ A+PL R++P+N +QY+ W V S PFEY + +I LNT+ L M+ Y S +
Sbjct: 1534 IDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAY 1593
Query: 1234 NDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSE 1293
+A+ + N+VFT +F++E VLKV+AF YF DAWN FD + V+GSI D+ ++E N
Sbjct: 1594 ENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGN-- 1651
Query: 1294 ESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIG 1353
N I+++F RLFR RL+KLL +G IR LLWTF++SF+ALPYV LLIAMLFFIYA+IG
Sbjct: 1652 --NFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1709
Query: 1354 MQMFGKVAM--------RDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL 1405
MQ+FG + + D QI +NNF+TF QA++LLFR ATGEAW IML+CL GK
Sbjct: 1710 MQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKP 1769
Query: 1406 CDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH 1465
CD S E CG+ FA YF+SF LC+FL++NLFVAVIMDNF+YLTRD SILGPH
Sbjct: 1770 CDKNSGILTRE---CGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPH 1826
Query: 1466 HLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS 1525
HLDE+ R+W+EYDP A GR+ +LD+ +LR + PPLG GK CP RVA KRL+ M++P+
Sbjct: 1827 HLDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMSPPLGLGKKCPARVAYKRLLRMDLPVAD 1886
Query: 1526 DGTVMFNATLFALVRTALKIKTE---GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAG 1582
D TV FN+TL AL+RTAL IK + +Q + ELR + IW S K LD +V P
Sbjct: 1887 DNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHK 1946
Query: 1583 DDEVTVGKFYATFLIQDYFRKFKKRKEQGL 1612
++TVGK YA +I +Y+R+ K +K Q +
Sbjct: 1947 STDLTVGKIYAAMMIMEYYRQSKAKKLQAM 1976
Score = 654 bits (1687), Expect = 0.0
Identities = 354/723 (48%), Positives = 470/723 (65%), Gaps = 38/723 (5%)
Query: 104 RALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEK 163
R+LF S +N +R+ I EW PF+ IL I ANC+ LA+ P+DD + L+
Sbjct: 76 RSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDD 135
Query: 164 VEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEG 223
E F+ IF E +KIIA G H +Y+RNGWN++DFV+V+ G+ + + +
Sbjct: 136 TEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------- 188
Query: 224 GNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 283
FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAM+PLL I LL+ F I+
Sbjct: 189 ----------FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAIL 238
Query: 284 IYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGG 343
I+AIIGLE ++GK H TCF +D + E PAPC R C NGT+C+ W GPN G
Sbjct: 239 IFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCP-NGTKCQPYWEGPNNG 297
Query: 344 ITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLG 403
IT FDN FA+LTVFQCITMEGWTD+LY NDA G W+YF+ L+I GSFF+LNLVLG
Sbjct: 298 ITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLG 357
Query: 404 VLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEE---- 459
VLSGEF+KERE+ + R F KLR +QQ+E +L GY++WI++AE++ +E GE+
Sbjct: 358 VLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPF 417
Query: 460 -GKRNTSMPTSETESVNTENVSGEGENRGCCGS--LCQAISKSKL--SRRWRRWNRFNRR 514
R T++ S+T+ +N E + + GS +I +KL S + + R R
Sbjct: 418 DALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRF 477
Query: 515 RCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKM 574
R VK+ FYW V+ LV LNTL ++ HYNQP+WL+ A + L LF EM +KM
Sbjct: 478 YIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKM 537
Query: 575 YSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWT 634
Y LG + YF S FN FDC V+ G I E I ++ + GISV R +RLLRIFKVT++W
Sbjct: 538 YGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWA 597
Query: 635 SLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQA 694
SL NLV SLLNSMKSI SLL LLFLFI++F+LLGMQLFGG+FNFDE T + FD FP A
Sbjct: 598 SLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDE-GTPPTNFDTFPAA 656
Query: 695 LLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDN 754
++TVFQILTGEDWN VMYDGI + GG GM+ IYFI+L + GNY LLNVFLAIAVDN
Sbjct: 657 IMTVFQILTGEDWNEVMYDGIKSQGG-VQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDN 715
Query: 755 LADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDED 814
LA+A+ L T ++E EE +K+A +++ E EV+ ++ ++ + + +E+ ++
Sbjct: 716 LANAQEL-TKDEQEEEEAANQKLALQKAKE-----VAEVSPLSAANMSIAV---KEQQKN 766
Query: 815 KDP 817
+ P
Sbjct: 767 QKP 769
Score = 217 bits (552), Expect = 1e-55
Identities = 180/719 (25%), Positives = 329/719 (45%), Gaps = 121/719 (16%)
Query: 67 QTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWK 126
Q + P P+ + K+++ + + P ++F LS NP+RR C I+ +
Sbjct: 1184 QVNKNANPDPLPKKEEEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLR 1243
Query: 127 PFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLL 186
F++ IL+ I + +ALA P + N+ L +Y F +FT E +K+I GL+
Sbjct: 1244 YFEMCILMVIAMSSIALAAEDPVQPNAPR--NNVLRYFDYVFTGVFTFEMVIKMIDLGLV 1301
Query: 187 LHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFD---VKALRAFR 243
LH AY R+ WN+LDF++V L + +G S G D +K+LR R
Sbjct: 1302 LHQGAYFRDLWNILDFIVVSGALVAFAF-------------TGNSKGKDINTIKSLRVLR 1348
Query: 244 VLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFF 303
VLRPL+ + +P L+ V + ++ ++ + +I ++ + + I+A++ ++LF GK FF
Sbjct: 1349 VLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGK-----FF 1403
Query: 304 ADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITM 363
+D ++E C G+ E ++ ++DN +A+LT+F T
Sbjct: 1404 HCTD-ESKEFEKDC----RGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTG 1458
Query: 364 EGWTDVLYWMNDA----------MGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKER 413
EGW VL DA E+ Y V V+F FFV N+ + ++ F ++
Sbjct: 1459 EGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFV-NIFVALIIITFQEQ- 1516
Query: 414 EKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETES 473
GD K+ E+ LE++ + +D+ A+
Sbjct: 1517 ------GD--KMMEEYSLEKNERACIDFAISAK--------------------------- 1541
Query: 474 VNTENVSGEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLV 533
L + + ++K S ++R W V S F + ++ ++
Sbjct: 1542 -----------------PLTRHMPQNKQSFQYRMWQ---------FVVSPPFEYTIMAMI 1575
Query: 534 FLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCF 593
LNT+ + + Y + N V +LF+ E ++K+ + G+ YF +N FD
Sbjct: 1576 ALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFV 1635
Query: 594 VVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASL 653
V G IT+ ++ E + + +S R R R+ K+ R ++ L+ + + S K++ +
Sbjct: 1636 TVLGSITDILVTEFG-NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1694
Query: 654 LLLLFLFIIIFSLLGMQLFGG--------KFNFDETQ-TKRSTFDNFPQALLTVFQILTG 704
LL+ + I++++GMQ+FG + DE Q T+ + F F QAL+ +F+ TG
Sbjct: 1695 CLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATG 1754
Query: 705 EDWNAVMYDGIMAYGGPSSSGMI--------VCIYFI-ILFICGNYILLNVFLAIAVDN 754
E W+ +M + +SG++ YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 1755 EAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1812
Score = 139 bits (350), Expect = 3e-32
Identities = 177/786 (22%), Positives = 321/786 (40%), Gaps = 168/786 (21%)
Query: 479 VSGEGENRGCCGSL------CQAISKSKLSRRWRRWNRFN----RRRC------------ 516
V G G RG GS Q + K +++R R +N R+ C
Sbjct: 24 VVGSGGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSE 83
Query: 517 ----RAAVKSVT----FYWLVIVLVFLNTLTISSEHYNQPDWLTQIQ---DIANKVLLAL 565
R K +T F ++++ + N + ++ E + D T + D + +
Sbjct: 84 DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 143
Query: 566 FTCEMLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCV 621
F E +K+ +LG +Y + +N D VV GI T+ E ++ + R V
Sbjct: 144 FCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT------LRAV 197
Query: 622 RLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFN---F 678
R+LR K+ SL ++ S++ +M + + LLLF I+IF+++G++ + GKF+ F
Sbjct: 198 RVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF 257
Query: 679 DE--------------TQTKRST--------------------FDNFPQALLTVFQILTG 704
+E T+ T FDN A+LTVFQ +T
Sbjct: 258 EEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITM 317
Query: 705 EDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTA 764
E W ++Y+ A G + +YFI L I G++ +LN+ L + A
Sbjct: 318 EGWTDLLYNSNDASGNTWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEFAK------- 365
Query: 765 QKEEAEEKER-KKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPC-- 821
++E E + K+ R++ +E + N E I+ ++ + +D + E + P+
Sbjct: 366 ERERVENRRAFLKLRRQQQIERELNGYME--WISKAEEVILAED-ETDGEQRHPFDALRR 422
Query: 822 --------DVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTN 873
D+ EE E++ D V + I + E S FF K
Sbjct: 423 TTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKL--------ENSTFFH-KKER 473
Query: 874 PIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVE 933
+R +++ F +L + L++ +A + + L Y ++ F +F E
Sbjct: 474 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH-YNQPEWLSDFLYYAEFIFLGLFMSE 532
Query: 934 ILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSL--VSFGIQSSAISV-VKILRVLRVLR 990
+ +KM G + + FN D V+ S+ V + + S + +LR LR+LR
Sbjct: 533 MFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLR 588
Query: 991 PLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKS 1050
+ L+++V + ++++I +++ + L +FA +G+QLF G+F
Sbjct: 589 IFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF--------- 639
Query: 1051 NPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKA 1110
+ D +P NFD +A+M +F + T E W ++Y
Sbjct: 640 -------------NFDEGTPPT----------NFDTFPAAIMTVFQILTGEDWNEVMYDG 676
Query: 1111 IDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVI--------VTFQEQGEKE 1162
I S G G + SI+FI+ + + ++N+F+ + +T EQ E+E
Sbjct: 677 IKSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEE 731
Query: 1163 YKNCEL 1168
N +L
Sbjct: 732 AANQKL 737
Score = 120 bits (302), Expect = 1e-26
Identities = 76/281 (27%), Positives = 136/281 (48%), Gaps = 29/281 (10%)
Query: 1181 KARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDIL 1240
K R +R YI + +V + F + + L+ LNTLC+A+ HY Q + +D +
Sbjct: 471 KERRMRFYIRR---------MVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 521
Query: 1241 NMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISI 1300
+F G+F EM +K+ + YF ++N FD ++IGSI +V + + I
Sbjct: 522 EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVI---KPGTSFGI 578
Query: 1301 TFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKV 1360
+ R R++R+ K+ +R L+ + + S +++ + L+ + ++A++GMQ+FG
Sbjct: 579 SVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQ 638
Query: 1361 AMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTC 1420
D NF TFP A++ +F+ TGE W E+M D +
Sbjct: 639 FNFDEG--TPPTNFDTFPAAIMTVFQILTGEDWNEVMY------------DGIKSQGGVQ 684
Query: 1421 GSNFAIVYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1458
G +YFI + + ++N+F+A+ +DN LT+D
Sbjct: 685 GGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 725
Score = 103 bits (257), Expect = 2e-21
Identities = 91/338 (26%), Positives = 158/338 (46%), Gaps = 47/338 (13%)
Query: 865 AFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAED--PIRSHSFRNTILGYF 922
+ F+ S+ N +R K+ F +IL I+ + LA E P + + L
Sbjct: 77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
Query: 923 DYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV--GVSLVSFGIQSSAISVV 980
+ F IF E +K+ G HKG++ RN +N++D +VV G+ L + G + +
Sbjct: 137 EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGI-LATVGTEFD----L 191
Query: 981 KILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGK 1040
+ LR +RVLRPL+ ++ L+ V++ + A+ + I ++ +FA IG++ + GK
Sbjct: 192 RTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGK 251
Query: 1041 FY-RCTDEAKSNPEECRGLFILYKDGDVDSPVVRER-------------IWQ---NSDFN 1083
F+ C +E + + G+ +P E W+ N
Sbjct: 252 FHTTCFEEGTDDIQ-----------GESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQ 300
Query: 1084 FDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFM 1143
FDN+L A++ +F T EGW LLY + D++G +Y FI III +FFM
Sbjct: 301 FDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLY---------FIPLIIIGSFFM 351
Query: 1144 MNIFVGFVIVTFQEQGEK-EYKNCELDKNQRQCVEYAL 1180
+N+ +G + F ++ E+ E + L ++Q +E L
Sbjct: 352 LNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIEREL 389
Score = 80.9 bits (198), Expect = 1e-14
Identities = 74/296 (25%), Positives = 131/296 (44%), Gaps = 61/296 (20%)
Query: 127 PFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLL 186
PF+ I+ I N + L + S + + L F +F++E LK++A+G+L
Sbjct: 1566 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1622
Query: 187 LHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLR 246
Y R+ WN+ DFV V+ + +++ TE GN+ ++ LR FR R
Sbjct: 1623 ----NYFRDAWNIFDFVTVLGSITDILV------TEFGNNF------INLSFLRLFRAAR 1666
Query: 247 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADS 306
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F G + DS
Sbjct: 1667 LIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-GNIGIDVEDEDS 1725
Query: 307 DIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGW 366
D ED Q T + NF F A++ +F+ T E W
Sbjct: 1726 D----EDEF---------QITEHN---------------NFRTFFQALMLLFRSATGEAW 1757
Query: 367 TDVLYW-------------MNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 409
+++ + G E + YFVS + SF +LNL + V+ F
Sbjct: 1758 HNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1813
Score = 75.5 bits (184), Expect = 5e-13
Identities = 67/293 (22%), Positives = 120/293 (40%), Gaps = 74/293 (25%)
Query: 1206 PFEYMMFVLIMLNTLCLAMQHY---EQSKMFNDAMDILNMVFTGVFTVEMVLKVIA---- 1258
PFEYM+ I+ N + LA++ + + ++ +D F G+F E +K+IA
Sbjct: 99 PFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFA 158
Query: 1259 FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMRLVKLLSRG 1318
F Y + WN D ++V+ I+ +E D + R RV+R +KL+S
Sbjct: 159 FHKGSYLRNGWNVMDFVVVLTGILATVGTEFD---------LRTLRAVRVLRPLKLVSGI 209
Query: 1319 EGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF-GKVAMR-------------- 1363
++ +L + +K+ L + LL+ I+A+IG++ + GK
Sbjct: 210 PSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESP 269
Query: 1364 ------------------------DNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLA 1399
NN I + F AVL +F+C T E W +++
Sbjct: 270 APCGTEEPARTCPNGTKCQPYWEGPNNGITQ---FDNILFAVLTVFQCITMEGWTDLL-- 324
Query: 1400 CLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1452
YN + G+ + +YFI ++ +F ++NL + V+ F
Sbjct: 325 ------------YNSND--ASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 363
>gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B
subunit [Homo sapiens]
Length = 2339
Score = 765 bits (1976), Expect = 0.0
Identities = 415/908 (45%), Positives = 572/908 (62%), Gaps = 58/908 (6%)
Query: 822 DVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHK 881
D+ E ++E E + + +GPRP I P S+ F LS TN +R CH
Sbjct: 1100 DLESQAEGKKEVEADDVMRSGPRP-----------IVPY---SSMFCLSPTNLLRRFCHY 1145
Query: 882 LINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTF 941
++ F +ILV I LSS ALAAEDP+R+ S RN L Y DY FT +FT E+++KM
Sbjct: 1146 IVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDL 1205
Query: 942 GAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSA---ISVVKILRVLRVLRPLRAINRA 998
G LH GA+ R+ +N+LD +VV +LV+F S I+ +K LRVLRVLRPL+ I R
Sbjct: 1206 GLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRL 1265
Query: 999 KGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGL 1058
LK V CV +++ + NI+IV L F+FA I VQLFKGKF+ CTDE+K +CRG
Sbjct: 1266 PKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQ 1325
Query: 1059 FILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENI 1118
++ Y+ +V++ + R W+ DF++DNVL A++ LFTVST EGWP +L ++D+ E
Sbjct: 1326 YLDYEKEEVEA---QPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQ 1382
Query: 1119 GPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEY 1178
GP +R+E+SIF+++Y ++ FF +NIFV +I+TFQEQG+K C L+KN+R C+++
Sbjct: 1383 GPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDF 1442
Query: 1179 ALKARPLRRYIPKN--PYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDA 1236
A+ A+PL RY+P+N +QYK W V S PFEY + +I LNT+ L M+ Y+ +
Sbjct: 1443 AISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELM 1502
Query: 1237 MDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESN 1296
+ LN+VFT +F++E VLK+IAF YF DAWN FD + V+GSI D+ ++E +E +N
Sbjct: 1503 LKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI--AETNN 1560
Query: 1297 RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQM 1356
I+++F RLFR RL+KLL +G IR LLWTF++SF+ALPYV LLIAMLFFIYA+IGMQ+
Sbjct: 1561 FINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQV 1620
Query: 1357 FGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE 1416
FG +A+ D+ INR+NNF+TF QA++LLFR ATGEAW EIML+CL + CD +++
Sbjct: 1621 FGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQANAT--- 1677
Query: 1417 EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSE 1476
CGS+FA YF+SF LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF R+W+E
Sbjct: 1678 --ECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAE 1735
Query: 1477 YDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPL-NSDGTVMFNATL 1535
YDP A GRI + D+ +L+ + PPLG GK CP RVA KRLV MNMP+ N D TV F +TL
Sbjct: 1736 YDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTL 1795
Query: 1536 FALVRTALKIK---TEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFY 1592
AL+RTAL+IK Q + ELR I +W K LD +VPP DE+TVGK Y
Sbjct: 1796 MALIRTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVY 1855
Query: 1593 ATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGP-EIRRAISCDLQDDE 1651
A +I D++++ K ++Q +Q L +GP + + L+ +
Sbjct: 1856 AALMIFDFYKQNKTTRDQ--------------MQQAPGGLSQMGPVSLFHPLKATLEQTQ 1901
Query: 1652 PEETK------REEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPP 1705
P + R++ GA+ N + + T T H RP +
Sbjct: 1902 PAVLRGARVFLRQKSSTSLSNGGAI----QNQESGIKESVSWGTQRTQDAPHEARPPLER 1957
Query: 1706 ASDTEKPL 1713
TE P+
Sbjct: 1958 GHSTEIPV 1965
Score = 625 bits (1612), Expect = e-178
Identities = 348/692 (50%), Positives = 448/692 (64%), Gaps = 35/692 (5%)
Query: 104 RALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEK 163
R+LF S +N +R+ I EW PF+ IL I ANC+ LA+ P+ D + L+
Sbjct: 73 RSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDD 132
Query: 164 VEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEG 223
E F+ IF E +KIIA G + H +Y+RNGWN++DFV+V+ G+ + T G
Sbjct: 133 TEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---------TAG 183
Query: 224 GNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 283
+ FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAMVPLL I LL+ F I+
Sbjct: 184 TD--------FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIL 235
Query: 284 IYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGG 343
++AIIGLE ++GK HK CF +D D PC R C + TECR W GPN G
Sbjct: 236 MFAIIGLEFYMGKFHKACFPNSTDAEPVGD-FPCGKEAPARLCEGD-TECREYWPGPNFG 293
Query: 344 ITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLG 403
ITNFDN FA+LTVFQCITMEGWTD+LY NDA G W+YF+ L+I GSFF+LNLVLG
Sbjct: 294 ITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLG 353
Query: 404 VLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRN 463
VLSGEF+KERE+ + R F KLR +QQ+E +L GYL+WI +AE++ E+ EE
Sbjct: 354 VLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPL 413
Query: 464 TSMPTSETESVNTENVSGE-GENRGCCGSLCQAIS----------KSKLSRRWRRWNRFN 512
+ + T+ + + E GE+R LC S K++ S +RR +
Sbjct: 414 DVLKRAATKKSRNDLIHAEEGEDR--FADLCAVGSPFARASLKSGKTESSSYFRRKEKMF 471
Query: 513 RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLV 572
R R VK+ +FYW+V+ +V LNTL ++ HYNQP LT A V L LF EM +
Sbjct: 472 RFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSL 531
Query: 573 KMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRH 632
KMY LG ++YF S FN FD V+ G + E + ++ S GISV R +RLLRIFKVT++
Sbjct: 532 KMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKY 591
Query: 633 WTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFP 692
W+SL NLV SLLNSMKSI SLL LLFLFI++F+LLGMQLFGG+FNF + +T + FD FP
Sbjct: 592 WSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQD-ETPTTNFDTFP 650
Query: 693 QALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAV 752
A+LTVFQILTGEDWNAVMY GI + GG S GM YFI+L + GNY LLNVFLAIAV
Sbjct: 651 AAILTVFQILTGEDWNAVMYHGIESQGG-VSKGMFSSFYFIVLTLFGNYTLLNVFLAIAV 709
Query: 753 DNLADAESLNTAQKEEAEEKERKKIARKESLE 784
DNLA+A+ L T +EE EE +K+A +++ E
Sbjct: 710 DNLANAQEL-TKDEEEMEEAANQKLALQKAKE 740
Score = 221 bits (562), Expect = 8e-57
Identities = 180/706 (25%), Positives = 325/706 (46%), Gaps = 106/706 (15%)
Query: 68 TMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKP 127
T+ S + S ++ K++ A + P ++FCLS N +RR C IV +
Sbjct: 1092 TVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRY 1151
Query: 128 FDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLL 187
F++ IL+ I + +ALA P D N+ L+ ++Y F +FT E +K+I GLLL
Sbjct: 1152 FEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYLDYIFTGVFTFEMVIKMIDLGLLL 1209
Query: 188 HPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRP 247
HP AY R+ WN+LDF++V L + + S GK +K+LR RVLRP
Sbjct: 1210 HPGAYFRDLWNILDFIVVSGALVAFAF----------SGSKGKDIN-TIKSLRVLRVLRP 1258
Query: 248 LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSD 307
L+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK + D
Sbjct: 1259 LKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF---YCTDES 1315
Query: 308 IVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWT 367
E D + A + + ++DN +A+LT+F T EGW
Sbjct: 1316 KELERDCRGQYLDYEKEEVEAQPRQWKK-------YDFHYDNVLWALLTLFTVSTGEGWP 1368
Query: 368 DVLYWMNDA----------MGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAK 417
VL DA EL Y V V+F FFV N+ + ++ F ++
Sbjct: 1369 MVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFV-NIFVALIIITFQEQ----- 1422
Query: 418 ARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTE 477
GD K+ + LE++ + +D+ A+
Sbjct: 1423 --GD--KVMSECSLEKNERACIDFAISAK------------------------------- 1447
Query: 478 NVSGEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNT 537
L + + +++ S +++ W V S F + ++ ++ LNT
Sbjct: 1448 -------------PLTRYMPQNRQSFQYKTW---------TFVVSPPFEYFIMAMIALNT 1485
Query: 538 LTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCG 597
+ + + Y+ P + N V ++F+ E ++K+ + G+ YF +N FD V G
Sbjct: 1486 VVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLG 1545
Query: 598 GITETILVEL-EIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLL 656
IT+ ++ E+ E + + +S R R R+ K+ R ++ L+ + + S K++ + LL
Sbjct: 1546 SITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLL 1605
Query: 657 LFLFIIIFSLLGMQLFGGKFNFDETQTKR-STFDNFPQALLTVFQILTGEDWNAVMYDGI 715
+ + I++++GMQ+FG D+T R + F F QAL+ +F+ TGE W+ +M +
Sbjct: 1606 IAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCL 1665
Query: 716 MAYGGPSSSGMIVC------IYFI-ILFICGNYILLNVFLAIAVDN 754
+ C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 1666 SNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
Score = 132 bits (333), Expect = 3e-30
Identities = 151/709 (21%), Positives = 299/709 (42%), Gaps = 121/709 (17%)
Query: 525 FYWLVIVLVFLNTLTISSEHYNQPDW----LTQIQDIANKVLLALFTCEMLVKMYSLGLQ 580
F ++++ + N + ++ E + PD +++ D + +F E +K+ +LG
Sbjct: 97 FEYMILATIIANCIVLALEQH-LPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFV 155
Query: 581 ----AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSL 636
+Y + +N D VV GI T + ++ + R VR+LR K+ SL
Sbjct: 156 FHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRT------LRAVRVLRPLKLVSGIPSL 209
Query: 637 SNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNF------------------ 678
++ S++ +M + + LLLF I++F+++G++ + GKF+
Sbjct: 210 QVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCG 269
Query: 679 ---------DETQTKR---------STFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGG 720
+T+ + + FDN A+LTVFQ +T E W ++Y+ A G
Sbjct: 270 KEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGN 329
Query: 721 PSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKER-KKIAR 779
+ +YFI L I G++ +LN+ L + A ++E E + K+ R
Sbjct: 330 TWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEFAK-------ERERVENRRAFLKLRR 377
Query: 780 KESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEV 839
++ +E + N E I ++ + EED + + P DV ++ D
Sbjct: 378 QQQIERELNGYLE--WIFKAEEVMLA----EEDRNAEEKSPLDVLKRAATKKSRNDLIHA 431
Query: 840 PAGP-RPRRISELNMKEKIAPIPEG---SAFFILSKTNPIRVGCHKLINHHIFTNLILVF 895
G R + + A + G S+ + K R +++ F ++L
Sbjct: 432 EEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCV 491
Query: 896 IMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYF 955
+ L++ +A + T+ + ++ F +F E+ LKM G ++ R+ F
Sbjct: 492 VALNTLCVAMVHYNQPRRLTTTLY-FAEFVFLGLFLTEMSLKMYGLGP----RSYFRSSF 546
Query: 956 NLLDM-LVVG--VSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAI 1012
N D ++VG +V I+ + + +LR LR+LR + L+++V + ++
Sbjct: 547 NCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSM 606
Query: 1013 RTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVV 1072
++I +++ + L +FA +G+QLF G+F DE +
Sbjct: 607 KSIISLLFLLFLFIVVFALLGMQLFGGQF-NFQDETPTT--------------------- 644
Query: 1073 RERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFF 1132
NFD +A++ +F + T E W A++Y I+S G +++ S +F
Sbjct: 645 ----------NFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFS-----SFYF 689
Query: 1133 IIYIIIVAFFMMNIFVGFVIVTFQEQGE--KEYKNCELDKNQRQCVEYA 1179
I+ + + ++N+F+ + E K+ + E NQ+ ++ A
Sbjct: 690 IVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKA 738
Score = 125 bits (313), Expect = 6e-28
Identities = 73/277 (26%), Positives = 140/277 (50%), Gaps = 24/277 (8%)
Query: 1188 YIPKNPYQYKFWY--VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFT 1245
Y + ++F+ +V + F +++ ++ LNTLC+AM HY Q + + VF
Sbjct: 463 YFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFL 522
Query: 1246 GVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRL 1305
G+F EM LK+ P+ YF ++N FD +++GS+ +V + + + I+ R
Sbjct: 523 GLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAI---KPGSSFGISVLRA 579
Query: 1306 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF-GKVAMRD 1364
R++R+ K+ +R L+ + + S +++ + L+ + ++A++GMQ+F G+ +D
Sbjct: 580 LRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQD 639
Query: 1365 NNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNF 1424
NF TFP A+L +F+ TGE W +M + + + + G F
Sbjct: 640 ETP---TTNFDTFPAAILTVFQILTGEDWNAVMYHGI-----ESQGGVSKG-------MF 684
Query: 1425 AIVYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1458
+ YFI + + ++N+F+A+ +DN LT+D
Sbjct: 685 SSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
Score = 108 bits (271), Expect = 4e-23
Identities = 87/325 (26%), Positives = 154/325 (47%), Gaps = 22/325 (6%)
Query: 865 AFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAED--PIRSHSFRNTILGYF 922
+ F+ S+ N +R ++ F +IL I+ + LA E P + + L
Sbjct: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
Query: 923 DYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKI 982
+ F IF E +K+ G HKG++ RN +N++D +VV +++ + ++
Sbjct: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRT 190
Query: 983 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY 1042
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GKF+
Sbjct: 191 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFH 250
Query: 1043 RCTDEAKSNPEECRGLFILYKDGDV---DSPVVRERIWQNSDF---NFDNVLSAMMALFT 1096
+ ++ E G F K+ + W +F NFDN+L A++ +F
Sbjct: 251 KACFPNSTDAEPV-GDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQ 309
Query: 1097 VSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQ 1156
T EGW +LY D+ G +Y FI III +FFM+N+ +G + F
Sbjct: 310 CITMEGWTDILYNTNDAAGNTWNWLY---------FIPLIIIGSFFMLNLVLGVLSGEFA 360
Query: 1157 EQGEK-EYKNCELDKNQRQCVEYAL 1180
++ E+ E + L ++Q +E L
Sbjct: 361 KERERVENRRAFLKLRRQQQIEREL 385
Score = 82.0 bits (201), Expect = 6e-15
Identities = 71/294 (24%), Positives = 128/294 (43%), Gaps = 65/294 (22%)
Query: 127 PFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLL 186
PF+ FI+ I N V L + D L+ + F +F++E LKIIA+G+L
Sbjct: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
Query: 187 LHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLR 246
Y R+ WN+ DFV V+ + +++ ++ + N S LR FR R
Sbjct: 1529 ----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSF----------LRLFRAAR 1574
Query: 247 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADS 306
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1575 LIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------G 1622
Query: 307 DIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGW 366
+I ++D + + NF F A++ +F+ T E W
Sbjct: 1623 NIALDDDTSINRHN-------------------------NFRTFLQALMLLFRSATGEAW 1657
Query: 367 TDVLY--WMNDAM---------GFELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 409
+++ N A G + + YFVS + SF +LNL + V+ F
Sbjct: 1658 HEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
Score = 76.6 bits (187), Expect = 2e-13
Identities = 66/289 (22%), Positives = 122/289 (42%), Gaps = 67/289 (23%)
Query: 1206 PFEYMMFVLIMLNTLCLAMQHY---EQSKMFNDAMDILNMVFTGVFTVEMVLKVIA---- 1258
PFEYM+ I+ N + LA++ + ++ +D F G+F E +K+IA
Sbjct: 96 PFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFV 155
Query: 1259 FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMRLVKLLSRG 1318
F Y + WN D ++V+ I+ A ++ D + R RV+R +KL+S
Sbjct: 156 FHKGSYLRNGWNVMDFVVVLTGILATAGTDFD---------LRTLRAVRVLRPLKLVSGI 206
Query: 1319 EGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF--------------------- 1357
++ +L + +K+ L + LL+ ++A+IG++ +
Sbjct: 207 PSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDF 266
Query: 1358 --GKVA---MRDNNQINRN---------NNFQTFPQAVLLLFRCATGEAWQEIMLACLPG 1403
GK A + + + R NF A+L +F+C T E W +I+
Sbjct: 267 PCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDIL------ 320
Query: 1404 KLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1452
YN + G+ + +YFI ++ +F ++NL + V+ F
Sbjct: 321 --------YNTND--AAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 359
>gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E
subunit [Homo sapiens]
Length = 2270
Score = 733 bits (1891), Expect = 0.0
Identities = 378/801 (47%), Positives = 536/801 (66%), Gaps = 25/801 (3%)
Query: 824 PVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLI 883
P+ E E E+E+E E + +R + M +P S+ FI S TNPIR CH ++
Sbjct: 1098 PLKEAEIREDEEEVEKKKQKKEKRETGKAM------VPH-SSMFIFSTTNPIRRACHYIV 1150
Query: 884 NHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGA 943
N F IL+ I SS ALAAEDP+ ++S RN +L YFDY FT +FT E+++KM G
Sbjct: 1151 NLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGL 1210
Query: 944 FLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSA-------ISVVKILRVLRVLRPLRAIN 996
L G++ R+ +N+LD +VV +LV+F + ++ I +K LRVLRVLRPL+ I
Sbjct: 1211 ILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIK 1270
Query: 997 RAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECR 1056
R LK V CV +++ + NI+IV L F+FA I VQLFKGKF+ CTD +K +EC
Sbjct: 1271 RLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECI 1330
Query: 1057 GLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGE 1116
G ++ D + + V+ R W+ +F++DN++ A++ LFTVST EGWP +L ++D E
Sbjct: 1331 GNYV---DHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1387
Query: 1117 NIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCV 1176
+ GP ++R+E+SIF+++Y ++ FF +NIFV +I+TFQEQG+K + C L+KN+R C+
Sbjct: 1388 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERACI 1447
Query: 1177 EYALKARPLRRYIPKN--PYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFN 1234
++A+ A+PL RY+P+N +QY+ W+ V S FEY + +I LNT+ L M++Y +
Sbjct: 1448 DFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYE 1507
Query: 1235 DAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEE 1294
A+ LN+ FT VF++E VLKVIAF YF D WN FD + VIGSI ++ L+++
Sbjct: 1508 LALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNT 1567
Query: 1295 SNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGM 1354
S +++F +LFR RL+KLL +G IR LLWTF++SF+ALPYV LLIAMLFFIYA+IGM
Sbjct: 1568 SG-FNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGM 1626
Query: 1355 QMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNP 1414
Q+FG + + + + INR+NNF++F +++LLFR ATGEAWQEIML+CL K C+P++
Sbjct: 1627 QVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPS 1686
Query: 1415 G--EEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKR 1472
G E CG++ A VYF+SF C+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF R
Sbjct: 1687 GQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFVR 1746
Query: 1473 IWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFN 1532
+W+EYD A GRI + ++ +L + PPLG GK CP +VA KRLV MNMP+ D TV F
Sbjct: 1747 VWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAEDMTVHFT 1806
Query: 1533 ATLFALVRTALKIKTE---GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVG 1589
+TL AL+RTAL IK + +Q + EL+ IW S K+LD +VP ++TVG
Sbjct: 1807 STLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKASDLTVG 1866
Query: 1590 KFYATFLIQDYFRKFKKRKEQ 1610
K YA +I DY+++ K +K++
Sbjct: 1867 KIYAAMMIMDYYKQSKVKKQR 1887
Score = 618 bits (1593), Expect = e-176
Identities = 362/775 (46%), Positives = 478/775 (61%), Gaps = 51/775 (6%)
Query: 33 PLSGEGPTSQPNSSKQTVL--SWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAK 90
P SG+G + Q + + T + S QAA +A+ A+TM+ P PV RQ
Sbjct: 12 PGSGDGDSDQSRNRQGTPVPASGQAAAYKQTKAQRARTMALYNPIPV-------RQNCFT 64
Query: 91 SKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFP 150
R+LF +N +R+ +++W PF+ IL I ANC+ LA+ P
Sbjct: 65 VN-----------RSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLP 113
Query: 151 EDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLF 210
EDD + LEK E F+ IF E +KI+A G + H +Y+RNGWN++DF++V+ G+
Sbjct: 114 EDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGIL 173
Query: 211 SVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVP 270
+ T T H D++ LRA RVLRPL+LVSG+PSLQ+VL SI+KAMVP
Sbjct: 174 A------TAGTHFNTH-------VDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVP 220
Query: 271 LLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPA-PCAFSGNGRQCTAN 329
LL I LL+ F I+++AIIGLE + GK+H+ CF +S I+ DP PC G C A
Sbjct: 221 LLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPCGVQG----CPA- 275
Query: 330 GTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSL 389
G EC+ W+GPN GIT FDN FA+LTVFQCITMEGWT VLY NDA+G W+YF+ L
Sbjct: 276 GYECKD-WIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPL 334
Query: 390 VIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDI- 448
+I GSFFVLNLVLGVLSGEF+KERE+ + R F KLR +QQ+E +L GY WI +AE++
Sbjct: 335 IIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVM 394
Query: 449 -DPENEEEGGE--EGKRNTSMPTSETESVNTENVSGEGENRGCCGS-LCQAISKSKLS-- 502
EN+ G E R ++ S TE++ ++ + G+ L +A KS
Sbjct: 395 LAEENKNAGTSALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDG 454
Query: 503 -RRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKV 561
+R R R R VKS FYW+V+ LV LNT ++ H+NQP WLT + A +
Sbjct: 455 VSYFRHKERLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFL 514
Query: 562 LLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCV 621
L LF EM +KMY +G + YF S FN FD V G I E + + GISV R +
Sbjct: 515 FLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRAL 574
Query: 622 RLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDET 681
RLLRIFK+T++W SL NLV SL++SMKSI SLL LLFLFI++F+LLGMQLFGG+FNF++
Sbjct: 575 RLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFND- 633
Query: 682 QTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNY 741
T + FD FP A++TVFQILTGEDWN VMY+GI + GG SSGM IYFI+L + GNY
Sbjct: 634 GTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGG-VSSGMWSAIYFIVLTLFGNY 692
Query: 742 ILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQI 796
LLNVFLAIAVDNLA+A+ L T ++E EE +K A +++ E + P + I
Sbjct: 693 TLLNVFLAIAVDNLANAQEL-TKDEQEEEEAFNQKHALQKAKEVSPMSAPNMPSI 746
Score = 213 bits (541), Expect = 2e-54
Identities = 173/704 (24%), Positives = 322/704 (45%), Gaps = 121/704 (17%)
Query: 82 QRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCV 141
++K+Q K +K+ P ++F S NPIRRAC IV + F++ ILL I A+ +
Sbjct: 1112 EKKKQ---KKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSI 1168
Query: 142 ALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLD 201
ALA P + N L +Y F +FT E +K+I GL+L +Y R+ WN+LD
Sbjct: 1169 ALAAEDPVLTNSER--NKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILD 1226
Query: 202 FVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVL 261
FV+V+ L + L +G + + +K+LR RVLRPL+ + +P L+ V
Sbjct: 1227 FVVVVGALVAFALANALGTNKGRDIKT-------IKSLRVLRVLRPLKTIKRLPKLKAVF 1279
Query: 262 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSG 321
+ ++ ++ + +I ++ + I+A+I ++LF GK FF +D + +
Sbjct: 1280 DCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGK-----FFYCTDSSKDTE-------- 1326
Query: 322 NGRQCTANGTECRSGWVGPNG-----GITNFDNFAFAMLTVFQCITMEGWTDVLYWMND- 375
++C N + + G ++DN +A+LT+F T EGW VL D
Sbjct: 1327 --KECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDV 1384
Query: 376 ---------AMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLR 426
+ E+ Y V V+F FFV N+ + ++ F ++ GD K+
Sbjct: 1385 TEEDRGPSRSNRMEMSIFYVVYFVVFPFFFV-NIFVALIIITFQEQ-------GD--KMM 1434
Query: 427 EKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVSGEGENR 486
E+ LE++ + +D+ A+
Sbjct: 1435 EECSLEKNERACIDFAISAK---------------------------------------- 1454
Query: 487 GCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYN 546
L + + +++ + ++R W+ V S +F + ++ ++ LNT+ + ++Y+
Sbjct: 1455 ----PLTRYMPQNRHTFQYRVWH---------FVVSPSFEYTIMAMIALNTVVLMMKYYS 1501
Query: 547 QPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVE 606
P N +F+ E ++K+ + G YF +N FD V G ITE IL +
Sbjct: 1502 APCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTD 1561
Query: 607 LEIMSPLG--ISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIF 664
++++ G +S + R R+ K+ R ++ L+ + + S K++ + LL+ + I+
Sbjct: 1562 SKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIY 1621
Query: 665 SLLGMQLFGG-KFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYG---- 719
+++GMQ+FG K + + + + F +F +L+ +F+ TGE W +M + G
Sbjct: 1622 AIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPD 1681
Query: 720 --GPSSSGM-------IVCIYFIILFICGNYILLNVFLAIAVDN 754
PS + +YF+ ++++LN+F+A+ +DN
Sbjct: 1682 TTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
Score = 191 bits (485), Expect = 7e-48
Identities = 168/684 (24%), Positives = 298/684 (43%), Gaps = 126/684 (18%)
Query: 865 AFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAED--PIRSHSFRNTILGYF 922
+ FI + N +R KLI+ F +IL I+ + LA E P + + L
Sbjct: 68 SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
Query: 923 DYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV--GVSLVSFGIQSSAISVV 980
+ F IF E +K+ G HKG++ RN +N++D +VV G+ L + G + +
Sbjct: 128 EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGI-LATAGTHFNTHVDL 186
Query: 981 KILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGK 1040
+ LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GK
Sbjct: 187 RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGK 246
Query: 1041 FYRCTDEAKSN-------PEEC--RGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAM 1091
+R S P C +G Y+ D P + FDN+L A+
Sbjct: 247 LHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGP-------NDGITQFDNILFAV 299
Query: 1092 MALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVG-- 1149
+ +F T EGW +LY D+ +G +N ++FI III +FF++N+ +G
Sbjct: 300 LTVFQCITMEGWTTVLYNTNDA----LGATWNW-----LYFIPLIIIGSFFVLNLVLGVL 350
Query: 1150 ----------------FVIVTFQEQGEKEYKNCEL------------------------- 1168
F+ + Q+Q E+E
Sbjct: 351 SGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVL 410
Query: 1169 ---------------DKNQRQCVEYALKARPLRRYIPKNP-------YQYK-------FW 1199
D + CV+ + PL R K+ +++K
Sbjct: 411 RRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIR 470
Query: 1200 YVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAF 1259
++V S F +++ L+ LNT C+A+ H+ Q + + +F G+F +EM LK+
Sbjct: 471 HMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGM 530
Query: 1260 KPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMRLVKLLSRGE 1319
P+ YF ++N FD + +GSI +V + I+ R R++R+ K+
Sbjct: 531 GPRLYFHSSFNCFDFGVTVGSIFEVVWA---IFRPGTSFGISVLRALRLLRIFKITKYWA 587
Query: 1320 GIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQ 1379
+R L+ + + S +++ + L+ + ++A++GMQ+FG + N + NF TFP
Sbjct: 588 SLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG--GRFNFNDGTPSANFDTFPA 645
Query: 1380 AVLLLFRCATGEAWQEIMLACLPGKLCDPESDYN--PGEEYTCGSNFAIVYFISFYMLCA 1437
A++ +F+ TGE W E+M YN + ++ +YFI +
Sbjct: 646 AIMTVFQILTGEDWNEVM--------------YNGIRSQGGVSSGMWSAIYFIVLTLFGN 691
Query: 1438 FLIINLFVAVIMDNF---DYLTRD 1458
+ ++N+F+A+ +DN LT+D
Sbjct: 692 YTLLNVFLAIAVDNLANAQELTKD 715
Score = 131 bits (330), Expect = 6e-30
Identities = 157/736 (21%), Positives = 301/736 (40%), Gaps = 139/736 (18%)
Query: 513 RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKV---LLALFTCE 569
R+ + + F ++++ + N + ++ E + D T + K + +F E
Sbjct: 79 RKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFE 138
Query: 570 MLVKMYSLGL----QAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLR 625
+K+ +LG +Y + +N D VV GI T + + + R VR+LR
Sbjct: 139 AGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFN--THVDLRTLRAVRVLR 196
Query: 626 IFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFN-------- 677
K+ SL ++ S++ +M + + LLLF I++F+++G++ + GK +
Sbjct: 197 PLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNS 256
Query: 678 -----FDETQTKR--------------------STFDNFPQALLTVFQILTGEDWNAVMY 712
FD + FDN A+LTVFQ +T E W V+Y
Sbjct: 257 GILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLY 316
Query: 713 DGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEK 772
+ A G + +YFI L I G++ +LN+ L + A ++E E +
Sbjct: 317 NTNDALGATWN-----WLYFIPLIIIGSFFVLNLVLGVLSGEFAK-------ERERVENR 364
Query: 773 ER-KKIARKESLENKKN------NKPEVNQIANSDN-----------KVTIDDYREEDED 814
K+ R++ +E + N +K E +A + + TI R E
Sbjct: 365 RAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMT 424
Query: 815 KDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNP 874
+D DE V ++ ++K +G ++F K
Sbjct: 425 RD----------------SSDEHCVDISSVGTPLARASIKSAKV---DGVSYF-RHKERL 464
Query: 875 IRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEI 934
+R+ ++ +F ++L + L++A +A + +L Y ++ F +F +E+
Sbjct: 465 LRISIRHMVKSQVFYWIVLSLVALNTACVAIVHH-NQPQWLTHLLYYAEFLFLGLFLLEM 523
Query: 935 LLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSL--VSFGIQSSAISV-VKILRVLRVLRP 991
LKM G L + + FN D V S+ V + I S + +LR LR+LR
Sbjct: 524 SLKMYGMGPRL----YFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRI 579
Query: 992 LRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSN 1051
+ L+++V + ++++I +++ + L +FA +G+QLF G+F
Sbjct: 580 FKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFN--------- 630
Query: 1052 PEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAI 1111
+ DG + NFD +A+M +F + T E W ++Y I
Sbjct: 631 ----------FNDGTPSA-------------NFDTFPAAIMTVFQILTGEDWNEVMYNGI 667
Query: 1112 DSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGE--KEYKNCELD 1169
S G +++ +I+FI+ + + ++N+F+ + E K+ + E
Sbjct: 668 RSQGGVSSGMWS-----AIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEA 722
Query: 1170 KNQRQCVEYALKARPL 1185
NQ+ ++ A + P+
Sbjct: 723 FNQKHALQKAKEVSPM 738
Score = 87.0 bits (214), Expect = 2e-16
Identities = 66/267 (24%), Positives = 122/267 (45%), Gaps = 68/267 (25%)
Query: 161 LEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKE 220
L+ + AF ++F++E LK+IA+G L Y R+ WN+ DF+ VI + +IL
Sbjct: 1510 LKYLNIAFTMVFSLECVLKVIAFGFL----NYFRDTWNIFDFITVIGSITEIILT----- 1560
Query: 221 TEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLF 280
+ + GF++ L+ FR R ++L+ +++++L + +++ L ++ LL+
Sbjct: 1561 ----DSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAM 1616
Query: 281 VIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGP 340
+ IYAIIG+++F +I +E+ S R
Sbjct: 1617 LFFIYAIIGMQVF------------GNIKLDEE------SHINRH--------------- 1643
Query: 341 NGGITNFDNFAFAMLTVFQCITMEGWTDVLYWM------------------NDAMGFELP 382
NF +F +++ +F+ T E W +++ N+ G +L
Sbjct: 1644 ----NNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLA 1699
Query: 383 WVYFVSLVIFGSFFVLNLVLGVLSGEF 409
+VYFVS + F SF +LNL + V+ F
Sbjct: 1700 YVYFVSFIFFCSFLMLNLFVAVIMDNF 1726
>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
[Homo sapiens]
Length = 2005
Score = 426 bits (1095), Expect = e-118
Identities = 332/1146 (28%), Positives = 555/1146 (48%), Gaps = 175/1146 (15%)
Query: 529 VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFN 588
+ + + LNTL ++ EHY + + + + N V +FT EM +K+ ++ YF +N
Sbjct: 765 ITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWN 824
Query: 589 RFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMK 648
FD F+V + E L +E G+SV R RLLR+FK+ + W +L+ L+ + NS+
Sbjct: 825 IFDGFIVSLSLMELGLANVE-----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 879
Query: 649 SIASLLLLLFLFIIIFSLLGMQLFGGKFN------FDETQTKRSTFDNFPQALLTVFQIL 702
++ +L L+L + + IF+++GMQLFG + ++ + R +F + L VF++L
Sbjct: 880 ALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVL 939
Query: 703 TGEDWNAVMYDGIMAYGGPSSSGMIVCI-YFIILFICGNYILLNVFLAIAV-----DNLA 756
GE W M+D + +G +C+ F+++ + GN ++LN+FLA+ + DNLA
Sbjct: 940 CGE-WIETMWDCM------EVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLA 992
Query: 757 ---DAESLNTAQ-------------KEEAEEKERKKIARK----------ESLENKKNN- 789
D +N Q K + E +K RK E L NKK++
Sbjct: 993 ATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSC 1052
Query: 790 -------------------KPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVP--VGE- 827
+ I +S K +D+ +P VP VGE
Sbjct: 1053 ISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGES 1112
Query: 828 ----------------EEEEEE-----------------------EDEPEVPAGPRPRRI 848
EE +E+ E EPE P
Sbjct: 1113 DFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFT 1172
Query: 849 SELNMKEKIAPIP----EGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALA 904
+ K K I +G ++ L KT C+K++ H+ F I+ I+LSS ALA
Sbjct: 1173 EDCVRKFKCCQISIEEGKGKLWWNLRKT------CYKIVEHNWFETFIVFMILLSSGALA 1226
Query: 905 AED-PIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV 963
ED I T+L Y D FT IF +E+LLK +G + N + LD L+V
Sbjct: 1227 FEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGF----QVYFTNAWCWLDFLIV 1282
Query: 964 GVSLVSF---GIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMI 1020
VSLVS + S + +K LR LR LRPLRA++R +G++ VV + AI +I N+++
Sbjct: 1283 DVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLL 1342
Query: 1021 VTTLLQFMFACIGVQLFKGKFYRCTD---------EAKSNPEECRGLFILYKDGDVDSPV 1071
V + +F+ +GV LF GKFY C + +N EC+ L ++S
Sbjct: 1343 VCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKAL--------IESNQ 1394
Query: 1072 VRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIF 1131
W+N NFDNV ++L V+TF+GW ++Y A+DS + P Y + + ++
Sbjct: 1395 TAR--WKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLY 1452
Query: 1132 FIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEY-ALK-------AR 1183
F+I+II +FF +N+F+G +I F +Q +K++ ++ + Q Y A+K +
Sbjct: 1453 FVIFIIFGSFFTLNLFIGVIIDNFNQQ-KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1511
Query: 1184 PLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMV 1243
P+ R P N +Q + V F+ + +LI LN + + ++ +QS+ + + +N+V
Sbjct: 1512 PIPR--PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLV 1569
Query: 1244 FTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFF 1303
F +FT E VLK+I+ + YF+ WN FD ++VI SI+ + L+E +
Sbjct: 1570 FIVLFTGECVLKLISLR-YYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVI 1628
Query: 1304 RLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMR 1363
RL R+ R+++L+ +GIRTLL+ + S AL + LL+ ++ FIYA+ GM F V +
Sbjct: 1629 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYV--K 1686
Query: 1364 DNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPG--KLCDPESDYNPGEEY--T 1419
I+ NF+TF +++ LF+ T W ++ L CDP+ D+ PG
Sbjct: 1687 REVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDH-PGSSVKGD 1745
Query: 1420 CGS-NFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS-ILGPHHLDEFKRIWSEY 1477
CG+ + I +F+S+ ++ +++N+++AVI++NF T + + L + F +W ++
Sbjct: 1746 CGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKF 1805
Query: 1478 DPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFA 1537
DP+A I+ + + PPL K P++V +L+AM++P+ S + LFA
Sbjct: 1806 DPDATQFIEFAKLSDFADALDPPLLIAK--PNKV---QLIAMDLPMVSGDRIHCLDILFA 1860
Query: 1538 LVRTAL 1543
+ L
Sbjct: 1861 FTKRVL 1866
Score = 147 bits (370), Expect = 1e-34
Identities = 107/376 (28%), Positives = 179/376 (47%), Gaps = 73/376 (19%)
Query: 105 ALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKV 164
AL+ L+ NPIR+ I I+ F++ I+ I NCV + + P P+ N V
Sbjct: 108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP-PDWTKN--------V 158
Query: 165 EYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGG 224
EY F I+T E+ +KI+A G L ++R+ WN LDF ++ +T+ G
Sbjct: 159 EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAY-------VTEFVNLG 211
Query: 225 NHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284
N V ALR FRVLR L+ +S +P L+ ++ ++I+++ L + +L +F + +
Sbjct: 212 N----------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV 261
Query: 285 YAIIGLELFIGKMHKTC----------------FFADS---------------------- 306
+A+IGL+LF+G + C FF +S
Sbjct: 262 FALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIE 321
Query: 307 ------DIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360
+ + D C S + QC G C PN G T+FD F++A L++F+
Sbjct: 322 DKSHFYFLEGQNDALLCGNSSDAGQC-PEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRL 380
Query: 361 ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG 420
+T + W + LY + + ++FV ++ GSF+++NL+L V++ + +E+ +A
Sbjct: 381 MTQDFWEN-LYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAY-EEQNQATLEE 438
Query: 421 DFQKLREKQQLEEDLK 436
QK E QQ+ E LK
Sbjct: 439 AEQKEAEFQQMLEQLK 454
Score = 137 bits (346), Expect = 9e-32
Identities = 98/328 (29%), Positives = 157/328 (47%), Gaps = 41/328 (12%)
Query: 115 IRRACISIVEWKPFDIFILLAIFANCVALA---IYIPFPEDDSNSTNHNLEKVEYAFLII 171
+R+ C IVE F+ FI+ I + ALA IYI + + LE + F I
Sbjct: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYI----EQRKTIKTMLEYADKVFTYI 1252
Query: 172 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231
F +E LK +AYG Y N W LDF+IV V L S+ L G
Sbjct: 1253 FILEMLLKWVAYGF----QVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGA------- 1301
Query: 232 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291
+K+LR R LRPLR +S ++VV+N+++ A+ ++++ L+ L +I++I+G+
Sbjct: 1302 ----IKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVN 1357
Query: 292 LFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTA-NGTECRSGWVGPNGGITNFDNF 350
LF GK + + ++ + N +C A + + W NFDN
Sbjct: 1358 LFAGKFYHCINYTTGEMF------DVSVVNNYSECKALIESNQTARWKNVK---VNFDNV 1408
Query: 351 AFAMLTVFQCITMEGWTDVLYWMNDAMGFELP---------WVYFVSLVIFGSFFVLNLV 401
L++ Q T +GW D++Y D+ EL ++YFV +IFGSFF LNL
Sbjct: 1409 GLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLF 1468
Query: 402 LGVLSGEFSKEREKAKARGDFQKLREKQ 429
+GV+ F+++++K + F +K+
Sbjct: 1469 IGVIIDNFNQQKKKFGGQDIFMTEEQKK 1496
Score = 126 bits (317), Expect = 2e-28
Identities = 78/258 (30%), Positives = 133/258 (51%), Gaps = 31/258 (12%)
Query: 1201 VVNSSPF-EYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAF 1259
+V PF + + + I+LNTL +AM+HY ++ F+ + + N+VFTG+FT EM LK+IA
Sbjct: 754 LVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAM 813
Query: 1260 KPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMRLVKLLSRGE 1319
P YF + WN FD IV S++++ L+ + ++ R FR++R+ KL
Sbjct: 814 DPYYYFQEGWNIFDGFIVSLSLMELGLANVE--------GLSVLRSFRLLRVFKLAKSWP 865
Query: 1320 GIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGK-----VAMRDNNQINRNNNF 1374
+ L+ S AL + L++A++ FI+AV+GMQ+FGK V N+ +
Sbjct: 866 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHM 925
Query: 1375 QTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYM 1434
F + L++FR GE W E M C+ G + F+ +
Sbjct: 926 HDFFHSFLIVFRVLCGE-WIETMWDCME----------------VAGQTMCLTVFMMVMV 968
Query: 1435 LCAFLIINLFVAVIMDNF 1452
+ +++NLF+A+++ +F
Sbjct: 969 IGNLVVLNLFLALLLSSF 986
Score = 102 bits (255), Expect = 3e-21
Identities = 101/434 (23%), Positives = 180/434 (41%), Gaps = 62/434 (14%)
Query: 398 LNLVLGVLSGEFSKER---EKAKARGDFQKLREKQQLEEDLKGY-LDWITQAEDIDPENE 453
L + + + GE E E+ + D ++ +EK +G +D AE PE E
Sbjct: 1101 LTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVE 1160
Query: 454 EEGGEEGKRNTSMPTSETESVNTENVSGEGENRGCCGSLCQAISKSKLSRRWRRWNRFNR 513
E + E E+ TE+ + + CQ + + W WN R
Sbjct: 1161 PE-----------ESLEPEACFTEDCVRKFK-------CCQISIEEGKGKLW--WNL--R 1198
Query: 514 RRCRAAVKSVTFYWLVIVLVFLNTLTISSE--HYNQPDWLTQIQDIANKVLLALFTCEML 571
+ C V+ F ++ ++ L++ ++ E + Q + + + A+KV +F EML
Sbjct: 1199 KTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEML 1258
Query: 572 VKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTR 631
+K + G Q YF + + D +V + L I R +R LR +
Sbjct: 1259 LKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALS 1318
Query: 632 HWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF--------------- 676
+ + +V +LL ++ SI ++LL+ +F +IFS++G+ LF GKF
Sbjct: 1319 RFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVS 1378
Query: 677 ---NFDE-------TQTKR-----STFDNFPQALLTVFQILTGEDWNAVMYDGI----MA 717
N+ E QT R FDN L++ Q+ T + W +MY + +
Sbjct: 1379 VVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVE 1438
Query: 718 YGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKI 777
+ + +YF+I I G++ LN+F+ + +DN + Q E+++K
Sbjct: 1439 LQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYY 1498
Query: 778 ARKESLENKKNNKP 791
+ L +KK KP
Sbjct: 1499 NAMKKLGSKKPQKP 1512
Score = 92.4 bits (228), Expect = 4e-18
Identities = 73/255 (28%), Positives = 123/255 (48%), Gaps = 20/255 (7%)
Query: 795 QIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEED-EPEVPAGPR----PRRIS 849
+IA K + ++ED++ P P D+ G+ D PE+ + P P I+
Sbjct: 28 RIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFIYGDIPPEMVSVPLEDLDPYYIN 87
Query: 850 E-----LNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALA 904
+ LN + I+ A +IL+ NPIR K++ H +F LI+ I+ + +
Sbjct: 88 KKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMT 147
Query: 905 AEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVG 964
+P + + +Y FT I+T E L+K+ G L F R+ +N LD V+
Sbjct: 148 MSNP---PDWTKNV----EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVIT 200
Query: 965 VSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTL 1024
+ V+ + +S LR RVLR L+ I+ GLK +V + +++ + ++MI+T
Sbjct: 201 FAYVTEFVNLGNVSA---LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVF 257
Query: 1025 LQFMFACIGVQLFKG 1039
+FA IG+QLF G
Sbjct: 258 CLSVFALIGLQLFMG 272
Score = 82.0 bits (201), Expect = 6e-15
Identities = 77/296 (26%), Positives = 133/296 (44%), Gaps = 61/296 (20%)
Query: 120 ISIVEWKPF-DIFILLAIFANCVALAI-YIPFPEDDSNSTNHNLEKVEYAFLIIFTVETF 177
+++V PF D+ I + I N + +A+ + P E S+ L F IFT E F
Sbjct: 752 VNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSV----LSVGNLVFTGIFTAEMF 807
Query: 178 LKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVK 237
LKIIA + P Y + GWN+ D IV + L + L + EG +
Sbjct: 808 LKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANV----EG------------LS 847
Query: 238 ALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKM 297
LR+FR+LR +L P+L +++ I ++ L ++ L++ ++ I+A++G++LF GK
Sbjct: 848 VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKS 906
Query: 298 HKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECR-SGWVGPNGGITNFDNFAFAMLT 356
+K C C S +C W + +F + L
Sbjct: 907 YKECV--------------CKIS----------NDCELPRW--------HMHDFFHSFLI 934
Query: 357 VFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKE 412
VF+ + E W + ++ + G + F+ +++ G+ VLNL L +L FS +
Sbjct: 935 VFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSD 989
Score = 78.6 bits (192), Expect = 6e-14
Identities = 80/394 (20%), Positives = 158/394 (40%), Gaps = 84/394 (21%)
Query: 80 LSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFAN 139
+++ +++ Y KK G+ +P N + V + FDI I++ I N
Sbjct: 1490 MTEEQKKYYNAMKKLGSKKPQKPIPRPA-----NKFQGMVFDFVTKQVFDISIMILICLN 1544
Query: 140 CVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNL 199
V + + +D S + L + F+++FT E LK+I+ Y GWN+
Sbjct: 1545 MVTMMVET---DDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYY-----YFTIGWNI 1596
Query: 200 LDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQV 259
DFV+VI+ + + L +L ++ + +R R+ R LRL+ G ++
Sbjct: 1597 FDFVVVILSIVGMFLAELIEKYFVSPTL--------FRVIRLARIGRILRLIKGAKGIRT 1648
Query: 260 VLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAF 319
+L +++ ++ L +I LL+ V+ IYAI G+ F + ++ ++
Sbjct: 1649 LLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA--------YVKREVGIDD------- 1693
Query: 320 SGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWM------ 373
+ NF+ F +M+ +FQ T GW +L +
Sbjct: 1694 ------------------------MFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPP 1729
Query: 374 --------------NDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFS---KEREKA 416
D + +FVS +I V+N+ + V+ FS +E +
Sbjct: 1730 DCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEP 1789
Query: 417 KARGDFQKLREK-QQLEEDLKGYLDWITQAEDID 449
+ DF+ E ++ + D ++++ ++ D
Sbjct: 1790 LSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFAD 1823
Score = 59.3 bits (142), Expect = 4e-08
Identities = 41/172 (23%), Positives = 82/172 (47%), Gaps = 19/172 (11%)
Query: 1190 PKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFT 1249
P NP + ++ S F ++ I+ N + + M + D + FTG++T
Sbjct: 114 PFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPP------DWTKNVEYTFTGIYT 167
Query: 1250 VEMVLKVIA----FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRL 1305
E ++K++A + + D WN D ++ + + +E N +++ R
Sbjct: 168 FESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYV---------TEFVNLGNVSALRT 218
Query: 1306 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF 1357
FRV+R +K +S G++T++ I+S + L V +L ++A+IG+Q+F
Sbjct: 219 FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
Score = 50.1 bits (118), Expect = 2e-05
Identities = 36/154 (23%), Positives = 70/154 (45%), Gaps = 16/154 (10%)
Query: 525 FYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ---- 580
F L++ + N + ++ N PDW ++ ++T E L+K+ + G
Sbjct: 131 FNMLIMCTILTNCVFMTMS--NPPDWTKNVE----YTFTGIYTFESLIKILARGFCLEDF 184
Query: 581 AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLV 640
+ +N D V+ T E ++ +S R R+LR K L +V
Sbjct: 185 TFLRDPWNWLDFTVI------TFAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIV 238
Query: 641 ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGG 674
+L+ S+K ++ +++L + +F+L+G+QLF G
Sbjct: 239 GALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 272
Score = 47.4 bits (111), Expect = 2e-04
Identities = 29/117 (24%), Positives = 59/117 (50%), Gaps = 9/117 (7%)
Query: 686 STFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLN 745
++FD F A L++F+++T + W + + A +G I+F+++ G++ L+N
Sbjct: 365 TSFDTFSWAFLSLFRLMTQDFWENLYQLTLRA------AGKTYMIFFVLVIFLGSFYLIN 418
Query: 746 VFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNK 802
+ LA+ E N A EEAE+KE + E L+ ++ A+++++
Sbjct: 419 LILAVVA---MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESR 472
Score = 37.0 bits (84), Expect = 0.21
Identities = 22/99 (22%), Positives = 47/99 (47%), Gaps = 10/99 (10%)
Query: 1083 NFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFF 1142
+FD A ++LF + T + W L + + G+ IFF++ I + +F+
Sbjct: 366 SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTY----------MIFFVLVIFLGSFY 415
Query: 1143 MMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALK 1181
++N+ + V + ++EQ + + E + + Q + LK
Sbjct: 416 LINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLK 454
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,418,487
Number of Sequences: 37866
Number of extensions: 3919149
Number of successful extensions: 27583
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 157
Number of HSP's successfully gapped in prelim test: 208
Number of HSP's that attempted gapping in prelim test: 19472
Number of HSP's gapped (non-prelim): 3181
length of query: 2137
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2019
effective length of database: 13,779,330
effective search space: 27820467270
effective search space used: 27820467270
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.