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Search of human proteins with 189217921
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|189217921 chloride channel 5 isoform a [Homo sapiens]
(816 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|189217923 chloride channel 5 isoform a [Homo sapiens] 1654 0.0
gi|189217921 chloride channel 5 isoform a [Homo sapiens] 1654 0.0
gi|4557473 chloride channel 5 isoform b [Homo sapiens] 1512 0.0
gi|55770838 chloride channel 3 isoform b [Homo sapiens] 1251 0.0
gi|153252026 chloride channel 4 [Homo sapiens] 1235 0.0
gi|55770840 chloride channel 3 isoform e [Homo sapiens] 1226 0.0
gi|167466160 chloride channel 7 isoform b [Homo sapiens] 261 2e-69
gi|14149607 chloride channel 7 isoform a [Homo sapiens] 261 2e-69
gi|156104869 chloride channel 2 [Homo sapiens] 224 2e-58
gi|4502873 chloride channel 6 isoform ClC-6a [Homo sapiens] 221 2e-57
gi|119433677 chloride channel 1, skeletal muscle [Homo sapiens] 209 8e-54
gi|112382220 chloride channel Ka isoform 1 [Homo sapiens] 187 3e-47
gi|112382222 chloride channel Ka isoform 2 [Homo sapiens] 186 6e-47
gi|155969705 chloride channel Kb [Homo sapiens] 186 1e-46
gi|12025671 chloride channel 6 isoform ClC-6c [Homo sapiens] 108 2e-23
gi|12025673 chloride channel 6 isoform ClC-6d [Homo sapiens] 61 4e-09
gi|12025668 chloride channel 6 isoform ClC-6b [Homo sapiens] 61 4e-09
gi|5032033 RNA binding motif protein 6 [Homo sapiens] 34 0.62
gi|38787991 transmembrane 4 superfamily member 8 isoform 2 [Homo... 31 5.3
gi|5032201 transmembrane 4 superfamily member 8 isoform 1 [Homo ... 31 5.3
>gi|189217923 chloride channel 5 isoform a [Homo sapiens]
Length = 816
Score = 1654 bits (4282), Expect = 0.0
Identities = 816/816 (100%), Positives = 816/816 (100%)
Query: 1 MAMWQGAMDNRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGEDKSYN 60
MAMWQGAMDNRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGEDKSYN
Sbjct: 1 MAMWQGAMDNRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGEDKSYN 60
Query: 61 GGGIGSSNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHS 120
GGGIGSSNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHS
Sbjct: 61 GGGIGSSNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHS 120
Query: 121 VSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTF 180
VSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTF
Sbjct: 121 VSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTF 180
Query: 181 EERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGI 240
EERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGI
Sbjct: 181 EERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGI 240
Query: 241 PEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFN 300
PEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFN
Sbjct: 241 PEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFN 300
Query: 301 KYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAF 360
KYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAF
Sbjct: 301 KYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAF 360
Query: 361 TLRSINPFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTT 420
TLRSINPFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTT
Sbjct: 361 TLRSINPFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTT 420
Query: 421 QLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTS 480
QLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTS
Sbjct: 421 QLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTS 480
Query: 481 KGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLG 540
KGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLG
Sbjct: 481 KGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLG 540
Query: 541 VGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTG 600
VGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTG
Sbjct: 541 VGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTG 600
Query: 601 GLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRR 660
GLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRR
Sbjct: 601 GLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRR 660
Query: 661 NDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKK 720
NDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKK
Sbjct: 661 NDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKK 720
Query: 721 QDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQ 780
QDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQ
Sbjct: 721 QDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQ 780
Query: 781 CLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN 816
CLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN
Sbjct: 781 CLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN 816
>gi|189217921 chloride channel 5 isoform a [Homo sapiens]
Length = 816
Score = 1654 bits (4282), Expect = 0.0
Identities = 816/816 (100%), Positives = 816/816 (100%)
Query: 1 MAMWQGAMDNRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGEDKSYN 60
MAMWQGAMDNRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGEDKSYN
Sbjct: 1 MAMWQGAMDNRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGEDKSYN 60
Query: 61 GGGIGSSNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHS 120
GGGIGSSNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHS
Sbjct: 61 GGGIGSSNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHS 120
Query: 121 VSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTF 180
VSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTF
Sbjct: 121 VSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTF 180
Query: 181 EERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGI 240
EERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGI
Sbjct: 181 EERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGI 240
Query: 241 PEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFN 300
PEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFN
Sbjct: 241 PEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFN 300
Query: 301 KYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAF 360
KYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAF
Sbjct: 301 KYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAF 360
Query: 361 TLRSINPFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTT 420
TLRSINPFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTT
Sbjct: 361 TLRSINPFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTT 420
Query: 421 QLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTS 480
QLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTS
Sbjct: 421 QLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTS 480
Query: 481 KGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLG 540
KGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLG
Sbjct: 481 KGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLG 540
Query: 541 VGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTG 600
VGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTG
Sbjct: 541 VGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTG 600
Query: 601 GLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRR 660
GLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRR
Sbjct: 601 GLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRR 660
Query: 661 NDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKK 720
NDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKK
Sbjct: 661 NDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKK 720
Query: 721 QDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQ 780
QDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQ
Sbjct: 721 QDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQ 780
Query: 781 CLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN 816
CLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN
Sbjct: 781 CLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN 816
>gi|4557473 chloride channel 5 isoform b [Homo sapiens]
Length = 746
Score = 1512 bits (3914), Expect = 0.0
Identities = 746/746 (100%), Positives = 746/746 (100%)
Query: 71 MDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFSGWLL 130
MDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFSGWLL
Sbjct: 1 MDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFSGWLL 60
Query: 131 MLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCPEWN 190
MLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCPEWN
Sbjct: 61 MLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCPEWN 120
Query: 191 SWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGF 250
SWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGF
Sbjct: 121 SWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGF 180
Query: 251 IIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNEAKRR 310
IIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNEAKRR
Sbjct: 181 IIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNEAKRR 240
Query: 311 EVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGN 370
EVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGN
Sbjct: 241 EVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGN 300
Query: 371 SRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYPVIEV 430
SRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYPVIEV
Sbjct: 301 SRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYPVIEV 360
Query: 431 LVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSKGGELPDRPA 490
LVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSKGGELPDRPA
Sbjct: 361 LVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSKGGELPDRPA 420
Query: 491 GVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYH 550
GVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYH
Sbjct: 421 GVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYH 480
Query: 551 QEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMA 610
QEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMA
Sbjct: 481 QEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMA 540
Query: 611 AAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQ 670
AAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQ
Sbjct: 541 AAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQ 600
Query: 671 DSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVVSTSII 730
DSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVVSTSII
Sbjct: 601 DSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVVSTSII 660
Query: 731 YFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLL 790
YFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLL
Sbjct: 661 YFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLL 720
Query: 791 GIITKKDVLKHIAQMANQDPDSILFN 816
GIITKKDVLKHIAQMANQDPDSILFN
Sbjct: 721 GIITKKDVLKHIAQMANQDPDSILFN 746
>gi|55770838 chloride channel 3 isoform b [Homo sapiens]
Length = 818
Score = 1251 bits (3238), Expect = 0.0
Identities = 596/811 (73%), Positives = 693/811 (85%), Gaps = 4/811 (0%)
Query: 10 NRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGEDKSY---NGGGIGS 66
+RG+ + S++S ++SSDE+L+D MDF +D LD + Y NGG I S
Sbjct: 8 HRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMTNGGSINS 67
Query: 67 SNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFS 126
S ++D L+EPIPGVGTYDDF+TIDWVREK +DR+RHR I +K KES W + S+ DA+S
Sbjct: 68 STHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWS 127
Query: 127 GWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKC 186
GWL++ L GL SG+LAGLIDI+A WMTDLKEGIC W+NHE CCW S TFEERDKC
Sbjct: 128 GWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKC 187
Query: 187 PEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTI 246
P+W +W++LII EG +YI+NY MY+ WAL FAFLAVSLVKVFAPYACGSGIPEIKTI
Sbjct: 188 PQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTI 247
Query: 247 LSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNE 306
LSGFIIRGYLGKWTL+IKTITLVLAV+SGLSLGKEGPLVHVACCCGNI + F KY NE
Sbjct: 248 LSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNE 307
Query: 307 AKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSIN 366
AK+REVLSAA+AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAF LRSIN
Sbjct: 308 AKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSIN 367
Query: 367 PFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYP 426
PFGNSRLVLFYVE+HTPW+LFEL PFILLG+FGGLWGA FIR NIAWCR+RK+T+ GKYP
Sbjct: 368 PFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYP 427
Query: 427 VIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSK-GGEL 485
V+EV++V AITA++AFPN YTR++TSELI ELF DCG L+SS LCDY N N SK ++
Sbjct: 428 VLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDI 487
Query: 486 PDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQ 545
PDRPAG+GVYSA+WQL L LI KI++T+FTFG+K+PSGLFIPSMA+GAIAGR++G+ +EQ
Sbjct: 488 PDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQ 547
Query: 546 LAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYI 605
LAYYH +W +F WC GADCITPGLYAMVGAAACLGGVTRMTVSLVVI+FELTGGLEYI
Sbjct: 548 LAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYI 607
Query: 606 VPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLL 665
VPLMAA MTSKWV DA GREGIY+AHIRLNGYPFL+AKEEF H TLA DVM+PRRNDP L
Sbjct: 608 VPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRNDPPL 667
Query: 666 TVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVV 725
VLTQD+MTV+D+E +I+ET+Y+GFPV++S+ESQRLVGF LRRDL I+IE+ARKKQ+G+V
Sbjct: 668 AVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGIV 727
Query: 726 STSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTH 785
+S + F +H+P LP +P LKLR+ILD+SPFTVTD TPMEIVVDIFRKLGLRQCLVTH
Sbjct: 728 GSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTH 787
Query: 786 NGRLLGIITKKDVLKHIAQMANQDPDSILFN 816
NGRLLGIITKKD+L+H+AQ ANQDP SI+FN
Sbjct: 788 NGRLLGIITKKDILRHMAQTANQDPASIMFN 818
>gi|153252026 chloride channel 4 [Homo sapiens]
Length = 760
Score = 1235 bits (3195), Expect = 0.0
Identities = 588/758 (77%), Positives = 674/758 (88%), Gaps = 1/758 (0%)
Query: 60 NGGGIGSSNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIH 119
N G + S +MDFL+EP P VGTY+DF+TIDW+REKSRD DRHR+IT+KSKES W I
Sbjct: 3 NAGAMSGSGNLMDFLDEPFPDVGTYEDFHTIDWLREKSRDTDRHRKITSKSKESIWEFIK 62
Query: 120 SVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVT 179
S+ DA+SGW++MLLIGLL+G+LAG+ID++ WMTDLKEG+C FW++HE CCW S T
Sbjct: 63 SLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETT 122
Query: 180 FEERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSG 239
FE+RDKCP W WS+L+++ EGA AYI+NY MY+LWALLFAFLAVSLV+VFAPYACGSG
Sbjct: 123 FEDRDKCPLWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSG 182
Query: 240 IPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCF 299
IPEIKTILSGFIIRGYLGKWTL+IKT+TLVL VSSGLSLGKEGPLVHVACCCGN F
Sbjct: 183 IPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSSLF 242
Query: 300 NKYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA 359
+KY KNE KRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA
Sbjct: 243 SKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA 302
Query: 360 FTLRSINPFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKT 419
FTLRSINPFGNSRLVLFYVE+HTPW++ EL PFILLG+FGGLWG LFIR NIAWCR+RKT
Sbjct: 303 FTLRSINPFGNSRLVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFIRCNIAWCRRRKT 362
Query: 420 TQLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFN- 478
T+LGKYPV+EV+VVTAITAI+A+PN YTR STSELISELFNDCG L+SS+LCDY N N
Sbjct: 363 TRLGKYPVLEVIVVTAITAIIAYPNPYTRQSTSELISELFNDCGALESSQLCDYINDPNM 422
Query: 479 TSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRL 538
T ++PDRPAGVGVY+AMWQLAL LI KIV+TIFTFGMKIPSGLFIPSMAVGAIAGR+
Sbjct: 423 TRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIPSMAVGAIAGRM 482
Query: 539 LGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFEL 598
+G+G+EQLAY+H +W +F +WC GADC+TPGLYAMVGAAACLGGVTRMTVSLVVIMFEL
Sbjct: 483 VGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMFEL 542
Query: 599 TGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKP 658
TGGLEYIVPLMAAA+TSKWVADA G+EGIY+AHI LNGYPFL+ K+EF H+TLA DVM+P
Sbjct: 543 TGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLATDVMRP 602
Query: 659 RRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENAR 718
RR +P L+VLTQDSMTVEDVET+I ET Y+GFPVVVSR+S+RL+GF RR+LI++I+NAR
Sbjct: 603 RRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQRRELILAIKNAR 662
Query: 719 KKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGL 778
++Q+G+VS SI+YFTE P LP +P LKLR IL+LSPFTVTD TPME VVDIFRKLGL
Sbjct: 663 QRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLSPFTVTDHTPMETVVDIFRKLGL 722
Query: 779 RQCLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN 816
RQCLVT +GRLLGIITKKDVL+H+AQMANQDP+SI+FN
Sbjct: 723 RQCLVTRSGRLLGIITKKDVLRHMAQMANQDPESIMFN 760
>gi|55770840 chloride channel 3 isoform e [Homo sapiens]
Length = 866
Score = 1226 bits (3172), Expect = 0.0
Identities = 583/800 (72%), Positives = 682/800 (85%), Gaps = 4/800 (0%)
Query: 10 NRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGEDKSY---NGGGIGS 66
+RG+ + S++S ++SSDE+L+D MDF +D LD + Y NGG I S
Sbjct: 8 HRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMTNGGSINS 67
Query: 67 SNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFS 126
S ++D L+EPIPGVGTYDDF+TIDWVREK +DR+RHR I +K KES W + S+ DA+S
Sbjct: 68 STHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWS 127
Query: 127 GWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKC 186
GWL++ L GL SG+LAGLIDI+A WMTDLKEGIC W+NHE CCW S TFEERDKC
Sbjct: 128 GWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKC 187
Query: 187 PEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTI 246
P+W +W++LII EG +YI+NY MY+ WAL FAFLAVSLVKVFAPYACGSGIPEIKTI
Sbjct: 188 PQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTI 247
Query: 247 LSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNE 306
LSGFIIRGYLGKWTL+IKTITLVLAV+SGLSLGKEGPLVHVACCCGNI + F KY NE
Sbjct: 248 LSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNE 307
Query: 307 AKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSIN 366
AK+REVLSAA+AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAF LRSIN
Sbjct: 308 AKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSIN 367
Query: 367 PFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYP 426
PFGNSRLVLFYVE+HTPW+LFEL PFILLG+FGGLWGA FIR NIAWCR+RK+T+ GKYP
Sbjct: 368 PFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYP 427
Query: 427 VIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSK-GGEL 485
V+EV++V AITA++AFPN YTR++TSELI ELF DCG L+SS LCDY N N SK ++
Sbjct: 428 VLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDI 487
Query: 486 PDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQ 545
PDRPAG+GVYSA+WQL L LI KI++T+FTFG+K+PSGLFIPSMA+GAIAGR++G+ +EQ
Sbjct: 488 PDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQ 547
Query: 546 LAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYI 605
LAYYH +W +F WC GADCITPGLYAMVGAAACLGGVTRMTVSLVVI+FELTGGLEYI
Sbjct: 548 LAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYI 607
Query: 606 VPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLL 665
VPLMAA MTSKWV DA GREGIY+AHIRLNGYPFL+AKEEF H TLA DVM+PRRNDP L
Sbjct: 608 VPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRNDPPL 667
Query: 666 TVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVV 725
VLTQD+MTV+D+E +I+ET+Y+GFPV++S+ESQRLVGF LRRDL I+IE+ARKKQ+G+V
Sbjct: 668 AVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGIV 727
Query: 726 STSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTH 785
+S + F +H+P LP +P LKLR+ILD+SPFTVTD TPMEIVVDIFRKLGLRQCLVTH
Sbjct: 728 GSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTH 787
Query: 786 NGRLLGIITKKDVLKHIAQM 805
NG +LGIITKK++L+H+ Q+
Sbjct: 788 NGIVLGIITKKNILEHLEQL 807
>gi|167466160 chloride channel 7 isoform b [Homo sapiens]
Length = 781
Score = 261 bits (667), Expect = 2e-69
Identities = 217/731 (29%), Positives = 352/731 (48%), Gaps = 124/731 (16%)
Query: 128 WLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCP 187
W++ LIG+L+G +A IDI + LK + G DK
Sbjct: 103 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNI-------------------DK-- 141
Query: 188 EWNSWSQLIISTDEGAFAYIVNYFMYVLWALL---FAFLAVSLVKVFAPYACGSGIPEIK 244
T++G + F +LWA L F + +V P A GSGIP+IK
Sbjct: 142 ----------FTEKGGLS-----FSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIK 186
Query: 245 TILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFN---- 300
L+G I + TLVIK ++L+V GL++GKEGP++H G+++ +
Sbjct: 187 CFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIH----SGSVIAAGISQGRS 242
Query: 301 ----------KYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWR 350
+Y + + ++R+ +SA AAAGVS AFGAP+GGVLFSLEE + ++ WR
Sbjct: 243 TSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWR 302
Query: 351 SFFAALVAAFTLRSINPFGNSRL-------VLFYVEFHT---PWHLFELVPFILLGIFGG 400
FFA++++ FTL + + + ++ + F + + + E+ FI +G+ GG
Sbjct: 303 IFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGG 362
Query: 401 LWGALFIRTNIAWCRKRKTTQLGK--YPVIEVLVVTAITAILAFPNEYTRMSTSELIS-- 456
+ GA+F N W + + + VIE ++V A+TA +AF Y+ L
Sbjct: 363 VLGAVFNALNY-WLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGS 421
Query: 457 -----ELFNDCGLLDSSKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVI 511
+LF G +S FNT + + G Y+ + L L ++ +
Sbjct: 422 MSYPLQLFCADGEYNSMAAA----FFNTPEKSVVSLFHDPPGSYNPL-TLGLFTLVYFFL 476
Query: 512 TIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGL 571
+T+G+ + +G+FIPS+ +GA GRL G+ + S+ + A PG
Sbjct: 477 ACWTYGLTVSAGVFIPSLLIGAAWGRLFGISL--------------SYLTGAAIWADPGK 522
Query: 572 YAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAH 631
YA++GAAA LGG+ RMT+SL VIM E T + Y P+M MT+K V D EG+YD H
Sbjct: 523 YALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVF-IEGLYDMH 581
Query: 632 IRLNGYPFLEAKEEF-AHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISET--TYS 688
I+L PFL + +H A +VM + P+ + ++ + V + ++S+T ++
Sbjct: 582 IQLQSVPFLHWEAPVTSHSLTAREVM----STPVTCLRRREKVGV--IVDVLSDTASNHN 635
Query: 689 GFPVVV---SRESQRLVGFVLRRDLIISIEN---ARKKQDGVVSTSIIY--FTEHSPPLP 740
GFPVV + RL G +LR LI+ +++ + G+V + F + P P
Sbjct: 636 GFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFP 695
Query: 741 PY---------TPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHN-GRLL 790
P T+ L ++ SP+TV + V +FR LGLR +V N +++
Sbjct: 696 PIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVV 755
Query: 791 GIITKKDVLKH 801
G++T+KD+ ++
Sbjct: 756 GLVTRKDLARY 766
>gi|14149607 chloride channel 7 isoform a [Homo sapiens]
Length = 805
Score = 261 bits (667), Expect = 2e-69
Identities = 217/731 (29%), Positives = 352/731 (48%), Gaps = 124/731 (16%)
Query: 128 WLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCP 187
W++ LIG+L+G +A IDI + LK + G DK
Sbjct: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNI-------------------DK-- 165
Query: 188 EWNSWSQLIISTDEGAFAYIVNYFMYVLWALL---FAFLAVSLVKVFAPYACGSGIPEIK 244
T++G + F +LWA L F + +V P A GSGIP+IK
Sbjct: 166 ----------FTEKGGLS-----FSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIK 210
Query: 245 TILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFN---- 300
L+G I + TLVIK ++L+V GL++GKEGP++H G+++ +
Sbjct: 211 CFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIH----SGSVIAAGISQGRS 266
Query: 301 ----------KYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWR 350
+Y + + ++R+ +SA AAAGVS AFGAP+GGVLFSLEE + ++ WR
Sbjct: 267 TSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWR 326
Query: 351 SFFAALVAAFTLRSINPFGNSRL-------VLFYVEFHT---PWHLFELVPFILLGIFGG 400
FFA++++ FTL + + + ++ + F + + + E+ FI +G+ GG
Sbjct: 327 IFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGG 386
Query: 401 LWGALFIRTNIAWCRKRKTTQLGK--YPVIEVLVVTAITAILAFPNEYTRMSTSELIS-- 456
+ GA+F N W + + + VIE ++V A+TA +AF Y+ L
Sbjct: 387 VLGAVFNALNY-WLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGS 445
Query: 457 -----ELFNDCGLLDSSKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVI 511
+LF G +S FNT + + G Y+ + L L ++ +
Sbjct: 446 MSYPLQLFCADGEYNSMAAA----FFNTPEKSVVSLFHDPPGSYNPL-TLGLFTLVYFFL 500
Query: 512 TIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGL 571
+T+G+ + +G+FIPS+ +GA GRL G+ + S+ + A PG
Sbjct: 501 ACWTYGLTVSAGVFIPSLLIGAAWGRLFGISL--------------SYLTGAAIWADPGK 546
Query: 572 YAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAH 631
YA++GAAA LGG+ RMT+SL VIM E T + Y P+M MT+K V D EG+YD H
Sbjct: 547 YALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVF-IEGLYDMH 605
Query: 632 IRLNGYPFLEAKEEF-AHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISET--TYS 688
I+L PFL + +H A +VM + P+ + ++ + V + ++S+T ++
Sbjct: 606 IQLQSVPFLHWEAPVTSHSLTAREVM----STPVTCLRRREKVGV--IVDVLSDTASNHN 659
Query: 689 GFPVVV---SRESQRLVGFVLRRDLIISIEN---ARKKQDGVVSTSIIY--FTEHSPPLP 740
GFPVV + RL G +LR LI+ +++ + G+V + F + P P
Sbjct: 660 GFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFP 719
Query: 741 PY---------TPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHN-GRLL 790
P T+ L ++ SP+TV + V +FR LGLR +V N +++
Sbjct: 720 PIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVV 779
Query: 791 GIITKKDVLKH 801
G++T+KD+ ++
Sbjct: 780 GLVTRKDLARY 790
>gi|156104869 chloride channel 2 [Homo sapiens]
Length = 898
Score = 224 bits (572), Expect = 2e-58
Identities = 174/558 (31%), Positives = 269/558 (48%), Gaps = 47/558 (8%)
Query: 186 CPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKT 245
C + W ++T + ++ Y +V + ++ + ++ AP A GSGIPE+KT
Sbjct: 115 CLQAQQWMSRGLNT-----SILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKT 169
Query: 246 ILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNIL---CHCFNKY 302
IL G +++ YL T + K I L A+ SG+ LGKEGP VH+A C +L F
Sbjct: 170 ILRGVVLKEYLTLKTFIAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGI 229
Query: 303 RKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTL 362
+NE++ E+L+AA A GV F APIGGVLFS+E S +F ++ WR FFAA +AF
Sbjct: 230 YENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIF 289
Query: 363 RSI---NPFGNSRLVLFYVEFHT--PWHLFELVPFILLGIFGGLWGALFIRTN---IAWC 414
R + N + LF F P+ L EL F ++GI G GALF+ N +
Sbjct: 290 RVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVM 349
Query: 415 RKRKTTQ--LGKYPVIEVLVVTAITAILAFPNEY-----TRMSTSELISELFNDCGLLDS 467
RK+KT L + ++ +VT + + L FP + ++S E + LF++ +
Sbjct: 350 RKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTWVRQ 409
Query: 468 SKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIP 527
+ + E +TS+ P + L + +++K ++ + +P G F+P
Sbjct: 410 GLVEELEPP-STSQAWNPPRA-------NVFLTLVIFILMKFWMSALATTIPVPCGAFMP 461
Query: 528 SMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRM 587
+GA GRL+G M W I PG YA+VGAAA G VT
Sbjct: 462 VFVIGAAFGRLVGESM-------AAWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTH- 513
Query: 588 TVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFA 647
TVS VI+FELTG + +I+P+M A + + VA +L + +YD+ IR+ P+L
Sbjct: 514 TVSTAVIVFELTGQIAHILPVMIAVILANAVAQSL-QPSLYDSIIRIKKLPYLPELGWGR 572
Query: 648 HKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLR 707
H+ + V D L S T D+ + T +V S ES L+G + R
Sbjct: 573 HQQYRVRVEDIMVRDVPHVAL---SCTFRDLRLALHRTKGRMLALVESPESMILLGSIER 629
Query: 708 RDLI----ISIENARKKQ 721
++ + AR++Q
Sbjct: 630 SQVVALLGAQLSPARRRQ 647
Score = 37.0 bits (84), Expect = 0.074
Identities = 19/50 (38%), Positives = 29/50 (58%)
Query: 753 LDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHI 802
+D +PF + + T + IF LG+ VT GRL+GI+T K++ K I
Sbjct: 790 IDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAI 839
>gi|4502873 chloride channel 6 isoform ClC-6a [Homo sapiens]
Length = 869
Score = 221 bits (563), Expect = 2e-57
Identities = 187/587 (31%), Positives = 283/587 (48%), Gaps = 83/587 (14%)
Query: 218 LLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLS 277
L F FLA SL+ + P A GSGIPE+K L+G + G + TL+ K + ++ +V+ GL
Sbjct: 138 LTFVFLA-SLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLF 196
Query: 278 LGKEGPLVHVACCCGNILCHC---------FN-KYRKNEAKRREVLSAAAAAGVSVAFGA 327
+GKEGP++H G L FN Y +++ +R+ +SA AAAGV+ AFGA
Sbjct: 197 VGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGA 256
Query: 328 PIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLR------SINPFGNSRL--VLFYVE 379
PIGG LFSLEE S ++ W+ F ++ A FTL +G+ +L +L + E
Sbjct: 257 PIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNFGE 316
Query: 380 FHTP--------WHLFELVPFILLGIFGGLWGALF--IRTNIAWCRKRKTTQLGK-YPVI 428
F W +L F+++G+ GGL GA F + +A R R K V+
Sbjct: 317 FKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHPKPKLVRVL 376
Query: 429 EVLVVTAITAILAFP-----NEYTRMSTSELIS------ELFNDCGLLDSSKLC------ 471
E L+V+ +T ++ F E +MS+S I ++ D + C
Sbjct: 377 ESLLVSLVTTVVVFVASMVLGECRQMSSSSQIGNDSFQLQVTEDVNSSIKTFFCPNDTYN 436
Query: 472 DYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAV 531
D F + + G +S + LAL +L ++ +T+G+ +PSGLF+PS+
Sbjct: 437 DMATLFFNPQESAILQLFHQDGTFSPV-TLALFFVLYFLLACWTYGISVPSGLFVPSLLC 495
Query: 532 GAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSL 591
GA GRL+ V S+ G I G +A++GAAA LGGV RMT+SL
Sbjct: 496 GAAFGRLVA-------------NVLKSYIGLGH--IYSGTFALIGAAAFLGGVVRMTISL 540
Query: 592 VVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEF-AHKT 650
VI+ E T + Y +P+M M +KW D + GIYD H+ L G P LE + E K
Sbjct: 541 TVILIESTNEITYGLPIMVTLMVAKWTGDFFNK-GIYDIHVGLRGVPLLEWETEVEMDKL 599
Query: 651 LAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVV---SRESQRLVGFVLR 707
A D+M+P LT + + ++ + +I+ T + FPVV E + + G L
Sbjct: 600 RASDIMEPN-----LTYVYPHT-RIQSLVSILRTTVHHAFPVVTENRGNEKEFMKGNQL- 652
Query: 708 RDLIISIENARKKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILD 754
I N K + + T + S + Y P+ +LRN+ D
Sbjct: 653 ------ISNNIKFKKSSILTRAGEQRKRSQSMKSY--PSSELRNMCD 691
Score = 33.9 bits (76), Expect = 0.62
Identities = 19/50 (38%), Positives = 30/50 (60%), Gaps = 1/50 (2%)
Query: 756 SPFTVTDLTPMEIVVDIFRKLGLRQC-LVTHNGRLLGIITKKDVLKHIAQ 804
SPFTV+ T + V ++FR +GLR +V G ++GIIT+ ++ Q
Sbjct: 810 SPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTYEFLQ 859
>gi|119433677 chloride channel 1, skeletal muscle [Homo sapiens]
Length = 988
Score = 209 bits (532), Expect = 8e-54
Identities = 164/532 (30%), Positives = 256/532 (48%), Gaps = 62/532 (11%)
Query: 208 VNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTIT 267
+ + ++V + L+ + + +P A GSGIPE+KTIL G +++ YL V K +
Sbjct: 159 LQFLVWVTFPLVLILFSALFCHLISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVA 218
Query: 268 LVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKY---RKNEAKRREVLSAAAAAGVSVA 324
L + SG+ +GKEGP VH+A C +L + + + ++L+ A GV
Sbjct: 219 LTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSVFCGVYEQPYYYSDILTVGCAVGVGCC 278
Query: 325 FGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRL---VLFYVEFH 381
FG P+GGVLFS+E S YF ++ WR FFAA +AF R + + + LF F
Sbjct: 279 FGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFR 338
Query: 382 T--PWHLFELVPFILLGIFGGLWGALFI---RTNIAWCRKRKTTQ--LGKYPVIEVLVVT 434
P+ L EL F +GI GL GA+F+ R + RK K L K+ ++ +VT
Sbjct: 339 MDFPFDLKELPAFAAIGICCGLLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGIVT 398
Query: 435 AITAILAFPNEYTRMSTSEL-----ISELFNDCGLLDSSKLCDYENRFNTSKGGELPDRP 489
+ A FP + EL IS LF +N G+ P
Sbjct: 399 FVIASFTFPPGMGQFMAGELMPREAISTLF--------------DNNTWVKHAGD----P 440
Query: 490 AGVGVYSAMW---------QLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLG 540
+G SA+W + L ++K ++I M IP G F+P +GA GRL+G
Sbjct: 441 ESLG-QSAVWIHPRVNVVIIIFLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVG 499
Query: 541 VGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTG 600
E +A + +F+ + I PG YA++GAAA G V+ TVS VI FELTG
Sbjct: 500 ---EIMAMLFPDGILFDDIIYK----ILPGGYAVIGAAALTGAVSH-TVSTAVICFELTG 551
Query: 601 GLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLE--AKEEFAHKTLAMDVMKP 658
+ +I+P+M A + + VA +L + +YD+ I++ P+L + + T+ ++ +
Sbjct: 552 QIAHILPMMVAVILANMVAQSL-QPSLYDSIIQVKKLPYLPDLGWNQLSKYTIFVEDIMV 610
Query: 659 RRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDL 710
R S T ++ T++ TT P+V S++S L+G V R +L
Sbjct: 611 RD-----VKFVSASYTYGELRTLLQTTTVKTLPLVDSKDSMILLGSVERSEL 657
Score = 32.3 bits (72), Expect = 1.8
Identities = 16/50 (32%), Positives = 27/50 (54%)
Query: 753 LDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHI 802
+D SPF + + T + +F LGL VT G+L G++ +++ K I
Sbjct: 821 IDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEELQKAI 870
>gi|112382220 chloride channel Ka isoform 1 [Homo sapiens]
Length = 687
Score = 187 bits (475), Expect = 3e-47
Identities = 174/646 (26%), Positives = 287/646 (44%), Gaps = 94/646 (14%)
Query: 205 AYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIK 264
++++ Y + ++ + + + P + GSGIPE+KT+L+G I+ YL K
Sbjct: 88 SHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAK 147
Query: 265 TITL--VLAVSSGLSLGKEGPLVH----VACCCGNILCHCFNKYRKNEAKRREVLSAAAA 318
+ L LA S L LGK GP VH +A G + + +N++K+ E+L AAAA
Sbjct: 148 VVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYLGRVRTTTIGE-PENKSKQNEMLVAAAA 206
Query: 319 AGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSR---LVL 375
GV+ F AP GVLFS+E +S +F ++ WR FFAA AF R + F + + L
Sbjct: 207 VGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETITSL 266
Query: 376 FYVEFH--TPWHLFELVPFILLGIFGGLWGAL-------------FIRTNIAWCRKRKTT 420
+ F P+ L E+ F+ L GG+ G L FI+TN + K T
Sbjct: 267 YKTSFRVDVPFDLPEIFFFVAL---GGICGVLSCAYLFCQRTFLSFIKTN-RYSSKLLAT 322
Query: 421 QLGKYPVIEVLVVTAITAILAFPNEY-----TRMSTSELISELFNDCGLLDSSKLCDYEN 475
Y + L++ +IT +P +R+S + + LF++ +
Sbjct: 323 SKPVYSALATLLLASIT----YPPGVGHFLASRLSMKQHLDSLFDN-------------H 365
Query: 476 RFNTSKGGELPDRPAGVGVYSAMWQ-----------LALTLILKIVITIFTFGMKIPSGL 524
+ P P + W+ LA L++K + I + +P+G
Sbjct: 366 SWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGY 425
Query: 525 FIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGV 584
F+P +GA GRLLG E LA E V + I PG YA+ GAAA G V
Sbjct: 426 FMPIFILGAAIGRLLG---EALAVAFPEGIVTGGVTNP----IMPGGYALAGAAAFSGAV 478
Query: 585 TRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLE--- 641
T T+S ++ FELTG + + +P++ A + + +A + + YD I + P+L
Sbjct: 479 TH-TISTALLAFELTGQIVHALPVLMAVLAANAIAQSC-QPSFYDGTIIVKKLPYLPRIL 536
Query: 642 AKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRL 701
+ +H M + +T L +D+ +E+V +++ T + +P+V S ESQ L
Sbjct: 537 GRNIGSHHVRVEHFM-----NHSITTLAKDT-PLEEVVKVVTSTDVTEYPLVESTESQIL 590
Query: 702 VGFVLRRDLIISIENARKKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVT 761
VG V R L+ +++ + + P P T T+
Sbjct: 591 VGIVQRAQLVQALQAEPPSRAPGHQQCLQDILARGCPTEPVT--------------LTLF 636
Query: 762 DLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHIAQMAN 807
T + ++F+ L L+ VT GR +G ++ ++ K I+ + N
Sbjct: 637 SETTLHQAQNLFKLLNLQSLFVTSRGRAVGCVSWVEMKKAISNLTN 682
>gi|112382222 chloride channel Ka isoform 2 [Homo sapiens]
Length = 686
Score = 186 bits (473), Expect = 6e-47
Identities = 179/652 (27%), Positives = 293/652 (44%), Gaps = 107/652 (16%)
Query: 205 AYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIK 264
++++ Y + ++ + + + P + GSGIPE+KT+L+G I+ YL K
Sbjct: 88 SHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAK 147
Query: 265 TITL--VLAVSSGLSLGKEGPLVH----VACCCGNILCHCFNKYRKNEAKRREVLSAAAA 318
+ L LA S L LGK GP VH +A G + + +N++K+ E+L AAAA
Sbjct: 148 VVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYLGRVRTTTIGE-PENKSKQNEMLVAAAA 206
Query: 319 AGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSR---LVL 375
GV+ F AP GVLFS+E +S +F ++ WR FFAA AF R + F + + L
Sbjct: 207 VGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETITSL 266
Query: 376 FYVEFH--TPWHLFELVPFILLGIFGGLWGAL-------------FIRTNIAWCRKRKTT 420
+ F P+ L E+ F+ L GG+ G L FI+TN + K T
Sbjct: 267 YKTSFRVDVPFDLPEIFFFVAL---GGICGVLSCAYLFCQRTFLSFIKTN-RYSSKLLAT 322
Query: 421 QLGKYPVIEVLVVTAITAILAFPNEY-----TRMSTSELISELFNDCGLLDSSKLCDYEN 475
Y + L++ +IT +P +R+S + + LF++ +
Sbjct: 323 SKPVYSALATLLLASIT----YPPGVGHFLASRLSMKQHLDSLFDN-------------H 365
Query: 476 RFNTSKGGELPDRPAGVGVYSAMWQ-----------LALTLILKIVITIFTFGMKIPSGL 524
+ P P + W+ LA L++K + I + +P+G
Sbjct: 366 SWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGY 425
Query: 525 FIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGV 584
F+P +GA GRLLG E LA E V + I PG YA+ GAAA G V
Sbjct: 426 FMPIFILGAAIGRLLG---EALAVAFPEGIVTGGVTNP----IMPGGYALAGAAAFSGAV 478
Query: 585 TRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLE--- 641
T T+S ++ FELTG + + +P++ A + + +A + + YD I + P+L
Sbjct: 479 TH-TISTALLAFELTGQIVHALPVLMAVLAANAIAQSC-QPSFYDGTIIVKKLPYLPRIL 536
Query: 642 AKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRL 701
+ +H M + +T L +D+ +E+V +++ T + +P+V S ESQ L
Sbjct: 537 GRNIGSHHVRVEHFM-----NHSITTLAKDT-PLEEVVKVVTSTDVTEYPLVESTESQIL 590
Query: 702 VGFVLRRDLIISIENARKKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNIL----DLSP 757
VG V R L+ +++ + P P P L++IL P
Sbjct: 591 VGIVQRAQLVQALQ--------------------AEP-PSRAPGHQCLQDILARGCPTEP 629
Query: 758 FTVT--DLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHIAQMAN 807
T+T T + ++F+ L L+ VT GR +G ++ ++ K I+ + N
Sbjct: 630 VTLTLFSETTLHQAQNLFKLLNLQSLFVTSRGRAVGCVSWVEMKKAISNLTN 681
>gi|155969705 chloride channel Kb [Homo sapiens]
Length = 687
Score = 186 bits (471), Expect = 1e-46
Identities = 175/638 (27%), Positives = 282/638 (44%), Gaps = 78/638 (12%)
Query: 205 AYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIK 264
++++ Y + ++ + + + P + GSGIPE+KT+L+G ++ YL K
Sbjct: 88 SHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEVKTMLAGVVLEDYLDIKNFGAK 147
Query: 265 TITL--VLAVSSGLSLGKEGPLVHV----ACCCGNILCHCFNKYRKNEAKRREVLSAAAA 318
+ L LA S L LGK GP VH+ A G + + +N++K+ E+L AAAA
Sbjct: 148 VVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTTTIGE-PENKSKQNEMLVAAAA 206
Query: 319 AGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSR---LVL 375
GV+ F AP GVLFS+E +S +F + WR FFAA AF R + F + + L
Sbjct: 207 VGVATVFAAPFSGVLFSIEVMSSHFSVWDYWRGFFAATCGAFMFRLLAVFNSEQETITSL 266
Query: 376 FYVEFH--TPWHLFELVPFILLGIFGGLWGAL----------FIRTNIAWCRKRKTTQLG 423
+ F P+ L E+ F+ LG G+ G+ FIR N + K T
Sbjct: 267 YKTSFRVDVPFDLPEIFFFVALGGLCGILGSAYLFCQRIFFGFIRNN-RFSSKLLATSKP 325
Query: 424 KYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSKGG 483
Y + LV+ +IT +P R S L + D L D+ + +
Sbjct: 326 VYSALATLVLASIT----YPPSAGRFLASRLSMKQHLD-SLFDN-------HSWALMTQN 373
Query: 484 ELPDRPAGVGVYSAMWQ-----------LALTLILKIVITIFTFGMKIPSGLFIPSMAVG 532
P P + W+ LA L++K + I + +P+G F+P G
Sbjct: 374 SSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFVYG 433
Query: 533 AIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLV 592
A GRL G E L++ E V + I PG YA+ GAAA G VT T+S
Sbjct: 434 AAIGRLFG---ETLSFIFPEGIVAGGITNP----IMPGGYALAGAAAFSGAVTH-TISTA 485
Query: 593 VIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLE---AKEEFAHK 649
++ FE+TG + + +P++ A + + +A + + YD + + P+L + +H+
Sbjct: 486 LLAFEVTGQIVHALPVLMAVLAANAIAQSC-QPSFYDGTVIVKKLPYLPRILGRNIGSHR 544
Query: 650 TLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRD 709
M + +T L +D M +E+V +++ T + +P+V S ESQ LVG V R
Sbjct: 545 VRVEHFM-----NHSITTLAKD-MPLEEVVKVVTSTDVAKYPLVESTESQILVGIVRRAQ 598
Query: 710 LIISIENARKKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIV 769
L+ +++ + P P T L LSP T +
Sbjct: 599 LVQALKAEPPSWAPGHQQCLQDILAAGCPTEPVT---------LKLSP-----ETSLHEA 644
Query: 770 VDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHIAQMAN 807
++F L L VT GR +G ++ ++ K I+ + N
Sbjct: 645 HNLFELLNLHSLFVTSRGRAVGCVSWVEMKKAISNLTN 682
>gi|12025671 chloride channel 6 isoform ClC-6c [Homo sapiens]
Length = 353
Score = 108 bits (270), Expect = 2e-23
Identities = 75/197 (38%), Positives = 105/197 (53%), Gaps = 27/197 (13%)
Query: 218 LLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLS 277
L F FLA SL+ + P A GSGIPE+K L+G + G + TL+ K + ++ +V+ GL
Sbjct: 138 LTFVFLA-SLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLF 196
Query: 278 LGKEGPLVHVACCCGNILCHC---------FN-KYRKNEAKRREVLSAAAAAGVSVAFGA 327
+GKEGP++H G L FN Y +++ +R+ +SA AAAGV+ AFGA
Sbjct: 197 VGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGA 256
Query: 328 PIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTL---RSINPFGNSRLVLFYVEFHTPW 384
PIGG LFSLEE S ++ W+ F ++ A FTL RS FG+ W
Sbjct: 257 PIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGS-------------W 303
Query: 385 HLFELVPFILLGIFGGL 401
F+L + G F L
Sbjct: 304 GSFQLPGLLNFGEFKSL 320
>gi|12025673 chloride channel 6 isoform ClC-6d [Homo sapiens]
Length = 308
Score = 61.2 bits (147), Expect = 4e-09
Identities = 32/75 (42%), Positives = 47/75 (62%), Gaps = 1/75 (1%)
Query: 218 LLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLS 277
L F FLA SL+ + P A GSGIPE+K L+G + G + TL+ K + ++ +V+ GL
Sbjct: 138 LTFVFLA-SLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLF 196
Query: 278 LGKEGPLVHVACCCG 292
+GKEGP++H G
Sbjct: 197 VGKEGPMIHSGSVVG 211
>gi|12025668 chloride channel 6 isoform ClC-6b [Homo sapiens]
Length = 320
Score = 61.2 bits (147), Expect = 4e-09
Identities = 32/75 (42%), Positives = 47/75 (62%), Gaps = 1/75 (1%)
Query: 218 LLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLS 277
L F FLA SL+ + P A GSGIPE+K L+G + G + TL+ K + ++ +V+ GL
Sbjct: 138 LTFVFLA-SLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLF 196
Query: 278 LGKEGPLVHVACCCG 292
+GKEGP++H G
Sbjct: 197 VGKEGPMIHSGSVVG 211
>gi|5032033 RNA binding motif protein 6 [Homo sapiens]
Length = 1123
Score = 33.9 bits (76), Expect = 0.62
Identities = 35/123 (28%), Positives = 56/123 (45%), Gaps = 24/123 (19%)
Query: 8 MDNRGFQQGSFSSFQNSS-SDEDLMDIPATAMDFSMRD----DVPPLDREVGE------- 55
+D R +Q S S F+N SD D D T +DF R D+ DR+
Sbjct: 203 LDFRAREQ-SRSDFRNRDVSDLDFRDKDGTQVDFRGRGSGTTDLDFRDRDTPHSDFRGRH 261
Query: 56 ----DKSYNGGGIGSSNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSK 111
D+ + G +GS M+F + +P V D N +D+++ ++DR+ N+ +
Sbjct: 262 RSRTDQDFRGREMGSC---MEFKDREMPPV----DPNILDYIQPSTQDREHSGMNVNRRE 314
Query: 112 EST 114
EST
Sbjct: 315 EST 317
>gi|38787991 transmembrane 4 superfamily member 8 isoform 2 [Homo
sapiens]
Length = 228
Score = 30.8 bits (68), Expect = 5.3
Identities = 12/41 (29%), Positives = 24/41 (58%), Gaps = 2/41 (4%)
Query: 57 KSYNGGGIGSSNRIMDFLEEPIP--GVGTYDDFNTIDWVRE 95
K+YNG +++R +D+++ + G+ Y D+ DW +E
Sbjct: 99 KTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKE 139
>gi|5032201 transmembrane 4 superfamily member 8 isoform 1 [Homo
sapiens]
Length = 253
Score = 30.8 bits (68), Expect = 5.3
Identities = 12/41 (29%), Positives = 24/41 (58%), Gaps = 2/41 (4%)
Query: 57 KSYNGGGIGSSNRIMDFLEEPIP--GVGTYDDFNTIDWVRE 95
K+YNG +++R +D+++ + G+ Y D+ DW +E
Sbjct: 124 KTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKE 164
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.139 0.432
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,978,691
Number of Sequences: 37866
Number of extensions: 1297814
Number of successful extensions: 3637
Number of sequences better than 10.0: 20
Number of HSP's better than 10.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 3553
Number of HSP's gapped (non-prelim): 31
length of query: 816
length of database: 18,247,518
effective HSP length: 111
effective length of query: 705
effective length of database: 14,044,392
effective search space: 9901296360
effective search space used: 9901296360
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.