Guide to the Human Genome
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Search of human proteins with 189217921

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|189217921 chloride channel 5 isoform a [Homo sapiens]
         (816 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|189217923 chloride channel 5 isoform a [Homo sapiens]             1654   0.0  
gi|189217921 chloride channel 5 isoform a [Homo sapiens]             1654   0.0  
gi|4557473 chloride channel 5 isoform b [Homo sapiens]               1512   0.0  
gi|55770838 chloride channel 3 isoform b [Homo sapiens]              1251   0.0  
gi|153252026 chloride channel 4 [Homo sapiens]                       1235   0.0  
gi|55770840 chloride channel 3 isoform e [Homo sapiens]              1226   0.0  
gi|167466160 chloride channel 7 isoform b [Homo sapiens]              261   2e-69
gi|14149607 chloride channel 7 isoform a [Homo sapiens]               261   2e-69
gi|156104869 chloride channel 2 [Homo sapiens]                        224   2e-58
gi|4502873 chloride channel 6 isoform ClC-6a [Homo sapiens]           221   2e-57
gi|119433677 chloride channel 1, skeletal muscle [Homo sapiens]       209   8e-54
gi|112382220 chloride channel Ka isoform 1 [Homo sapiens]             187   3e-47
gi|112382222 chloride channel Ka isoform 2 [Homo sapiens]             186   6e-47
gi|155969705 chloride channel Kb [Homo sapiens]                       186   1e-46
gi|12025671 chloride channel 6 isoform ClC-6c [Homo sapiens]          108   2e-23
gi|12025673 chloride channel 6 isoform ClC-6d [Homo sapiens]           61   4e-09
gi|12025668 chloride channel 6 isoform ClC-6b [Homo sapiens]           61   4e-09
gi|5032033 RNA binding motif protein 6 [Homo sapiens]                  34   0.62 
gi|38787991 transmembrane 4 superfamily member 8 isoform 2 [Homo...    31   5.3  
gi|5032201 transmembrane 4 superfamily member 8 isoform 1 [Homo ...    31   5.3  

>gi|189217923 chloride channel 5 isoform a [Homo sapiens]
          Length = 816

 Score = 1654 bits (4282), Expect = 0.0
 Identities = 816/816 (100%), Positives = 816/816 (100%)

Query: 1   MAMWQGAMDNRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGEDKSYN 60
           MAMWQGAMDNRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGEDKSYN
Sbjct: 1   MAMWQGAMDNRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGEDKSYN 60

Query: 61  GGGIGSSNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHS 120
           GGGIGSSNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHS
Sbjct: 61  GGGIGSSNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHS 120

Query: 121 VSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTF 180
           VSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTF
Sbjct: 121 VSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTF 180

Query: 181 EERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGI 240
           EERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGI
Sbjct: 181 EERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGI 240

Query: 241 PEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFN 300
           PEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFN
Sbjct: 241 PEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFN 300

Query: 301 KYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAF 360
           KYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAF
Sbjct: 301 KYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAF 360

Query: 361 TLRSINPFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTT 420
           TLRSINPFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTT
Sbjct: 361 TLRSINPFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTT 420

Query: 421 QLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTS 480
           QLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTS
Sbjct: 421 QLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTS 480

Query: 481 KGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLG 540
           KGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLG
Sbjct: 481 KGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLG 540

Query: 541 VGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTG 600
           VGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTG
Sbjct: 541 VGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTG 600

Query: 601 GLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRR 660
           GLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRR
Sbjct: 601 GLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRR 660

Query: 661 NDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKK 720
           NDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKK
Sbjct: 661 NDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKK 720

Query: 721 QDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQ 780
           QDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQ
Sbjct: 721 QDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQ 780

Query: 781 CLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN 816
           CLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN
Sbjct: 781 CLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN 816


>gi|189217921 chloride channel 5 isoform a [Homo sapiens]
          Length = 816

 Score = 1654 bits (4282), Expect = 0.0
 Identities = 816/816 (100%), Positives = 816/816 (100%)

Query: 1   MAMWQGAMDNRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGEDKSYN 60
           MAMWQGAMDNRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGEDKSYN
Sbjct: 1   MAMWQGAMDNRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGEDKSYN 60

Query: 61  GGGIGSSNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHS 120
           GGGIGSSNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHS
Sbjct: 61  GGGIGSSNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHS 120

Query: 121 VSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTF 180
           VSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTF
Sbjct: 121 VSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTF 180

Query: 181 EERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGI 240
           EERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGI
Sbjct: 181 EERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGI 240

Query: 241 PEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFN 300
           PEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFN
Sbjct: 241 PEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFN 300

Query: 301 KYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAF 360
           KYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAF
Sbjct: 301 KYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAF 360

Query: 361 TLRSINPFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTT 420
           TLRSINPFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTT
Sbjct: 361 TLRSINPFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTT 420

Query: 421 QLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTS 480
           QLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTS
Sbjct: 421 QLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTS 480

Query: 481 KGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLG 540
           KGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLG
Sbjct: 481 KGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLG 540

Query: 541 VGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTG 600
           VGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTG
Sbjct: 541 VGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTG 600

Query: 601 GLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRR 660
           GLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRR
Sbjct: 601 GLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRR 660

Query: 661 NDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKK 720
           NDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKK
Sbjct: 661 NDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKK 720

Query: 721 QDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQ 780
           QDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQ
Sbjct: 721 QDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQ 780

Query: 781 CLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN 816
           CLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN
Sbjct: 781 CLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN 816


>gi|4557473 chloride channel 5 isoform b [Homo sapiens]
          Length = 746

 Score = 1512 bits (3914), Expect = 0.0
 Identities = 746/746 (100%), Positives = 746/746 (100%)

Query: 71  MDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFSGWLL 130
           MDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFSGWLL
Sbjct: 1   MDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFSGWLL 60

Query: 131 MLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCPEWN 190
           MLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCPEWN
Sbjct: 61  MLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCPEWN 120

Query: 191 SWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGF 250
           SWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGF
Sbjct: 121 SWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGF 180

Query: 251 IIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNEAKRR 310
           IIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNEAKRR
Sbjct: 181 IIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNEAKRR 240

Query: 311 EVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGN 370
           EVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGN
Sbjct: 241 EVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGN 300

Query: 371 SRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYPVIEV 430
           SRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYPVIEV
Sbjct: 301 SRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYPVIEV 360

Query: 431 LVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSKGGELPDRPA 490
           LVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSKGGELPDRPA
Sbjct: 361 LVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSKGGELPDRPA 420

Query: 491 GVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYH 550
           GVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYH
Sbjct: 421 GVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYH 480

Query: 551 QEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMA 610
           QEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMA
Sbjct: 481 QEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMA 540

Query: 611 AAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQ 670
           AAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQ
Sbjct: 541 AAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQ 600

Query: 671 DSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVVSTSII 730
           DSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVVSTSII
Sbjct: 601 DSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVVSTSII 660

Query: 731 YFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLL 790
           YFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLL
Sbjct: 661 YFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLL 720

Query: 791 GIITKKDVLKHIAQMANQDPDSILFN 816
           GIITKKDVLKHIAQMANQDPDSILFN
Sbjct: 721 GIITKKDVLKHIAQMANQDPDSILFN 746


>gi|55770838 chloride channel 3 isoform b [Homo sapiens]
          Length = 818

 Score = 1251 bits (3238), Expect = 0.0
 Identities = 596/811 (73%), Positives = 693/811 (85%), Gaps = 4/811 (0%)

Query: 10  NRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGEDKSY---NGGGIGS 66
           +RG+ + S++S  ++SSDE+L+D     MDF   +D   LD +      Y   NGG I S
Sbjct: 8   HRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMTNGGSINS 67

Query: 67  SNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFS 126
           S  ++D L+EPIPGVGTYDDF+TIDWVREK +DR+RHR I +K KES W +  S+ DA+S
Sbjct: 68  STHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWS 127

Query: 127 GWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKC 186
           GWL++ L GL SG+LAGLIDI+A WMTDLKEGIC    W+NHE CCW S   TFEERDKC
Sbjct: 128 GWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKC 187

Query: 187 PEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTI 246
           P+W +W++LII   EG  +YI+NY MY+ WAL FAFLAVSLVKVFAPYACGSGIPEIKTI
Sbjct: 188 PQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTI 247

Query: 247 LSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNE 306
           LSGFIIRGYLGKWTL+IKTITLVLAV+SGLSLGKEGPLVHVACCCGNI  + F KY  NE
Sbjct: 248 LSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNE 307

Query: 307 AKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSIN 366
           AK+REVLSAA+AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAF LRSIN
Sbjct: 308 AKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSIN 367

Query: 367 PFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYP 426
           PFGNSRLVLFYVE+HTPW+LFEL PFILLG+FGGLWGA FIR NIAWCR+RK+T+ GKYP
Sbjct: 368 PFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYP 427

Query: 427 VIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSK-GGEL 485
           V+EV++V AITA++AFPN YTR++TSELI ELF DCG L+SS LCDY N  N SK   ++
Sbjct: 428 VLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDI 487

Query: 486 PDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQ 545
           PDRPAG+GVYSA+WQL L LI KI++T+FTFG+K+PSGLFIPSMA+GAIAGR++G+ +EQ
Sbjct: 488 PDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQ 547

Query: 546 LAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYI 605
           LAYYH +W +F  WC  GADCITPGLYAMVGAAACLGGVTRMTVSLVVI+FELTGGLEYI
Sbjct: 548 LAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYI 607

Query: 606 VPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLL 665
           VPLMAA MTSKWV DA GREGIY+AHIRLNGYPFL+AKEEF H TLA DVM+PRRNDP L
Sbjct: 608 VPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRNDPPL 667

Query: 666 TVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVV 725
            VLTQD+MTV+D+E +I+ET+Y+GFPV++S+ESQRLVGF LRRDL I+IE+ARKKQ+G+V
Sbjct: 668 AVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGIV 727

Query: 726 STSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTH 785
            +S + F +H+P LP  +P  LKLR+ILD+SPFTVTD TPMEIVVDIFRKLGLRQCLVTH
Sbjct: 728 GSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTH 787

Query: 786 NGRLLGIITKKDVLKHIAQMANQDPDSILFN 816
           NGRLLGIITKKD+L+H+AQ ANQDP SI+FN
Sbjct: 788 NGRLLGIITKKDILRHMAQTANQDPASIMFN 818


>gi|153252026 chloride channel 4 [Homo sapiens]
          Length = 760

 Score = 1235 bits (3195), Expect = 0.0
 Identities = 588/758 (77%), Positives = 674/758 (88%), Gaps = 1/758 (0%)

Query: 60  NGGGIGSSNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIH 119
           N G +  S  +MDFL+EP P VGTY+DF+TIDW+REKSRD DRHR+IT+KSKES W  I 
Sbjct: 3   NAGAMSGSGNLMDFLDEPFPDVGTYEDFHTIDWLREKSRDTDRHRKITSKSKESIWEFIK 62

Query: 120 SVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVT 179
           S+ DA+SGW++MLLIGLL+G+LAG+ID++  WMTDLKEG+C   FW++HE CCW S   T
Sbjct: 63  SLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETT 122

Query: 180 FEERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSG 239
           FE+RDKCP W  WS+L+++  EGA AYI+NY MY+LWALLFAFLAVSLV+VFAPYACGSG
Sbjct: 123 FEDRDKCPLWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSG 182

Query: 240 IPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCF 299
           IPEIKTILSGFIIRGYLGKWTL+IKT+TLVL VSSGLSLGKEGPLVHVACCCGN     F
Sbjct: 183 IPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSSLF 242

Query: 300 NKYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA 359
           +KY KNE KRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA
Sbjct: 243 SKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA 302

Query: 360 FTLRSINPFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKT 419
           FTLRSINPFGNSRLVLFYVE+HTPW++ EL PFILLG+FGGLWG LFIR NIAWCR+RKT
Sbjct: 303 FTLRSINPFGNSRLVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFIRCNIAWCRRRKT 362

Query: 420 TQLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFN- 478
           T+LGKYPV+EV+VVTAITAI+A+PN YTR STSELISELFNDCG L+SS+LCDY N  N 
Sbjct: 363 TRLGKYPVLEVIVVTAITAIIAYPNPYTRQSTSELISELFNDCGALESSQLCDYINDPNM 422

Query: 479 TSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRL 538
           T    ++PDRPAGVGVY+AMWQLAL LI KIV+TIFTFGMKIPSGLFIPSMAVGAIAGR+
Sbjct: 423 TRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIPSMAVGAIAGRM 482

Query: 539 LGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFEL 598
           +G+G+EQLAY+H +W +F +WC  GADC+TPGLYAMVGAAACLGGVTRMTVSLVVIMFEL
Sbjct: 483 VGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMFEL 542

Query: 599 TGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKP 658
           TGGLEYIVPLMAAA+TSKWVADA G+EGIY+AHI LNGYPFL+ K+EF H+TLA DVM+P
Sbjct: 543 TGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLATDVMRP 602

Query: 659 RRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENAR 718
           RR +P L+VLTQDSMTVEDVET+I ET Y+GFPVVVSR+S+RL+GF  RR+LI++I+NAR
Sbjct: 603 RRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQRRELILAIKNAR 662

Query: 719 KKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGL 778
           ++Q+G+VS SI+YFTE  P LP  +P  LKLR IL+LSPFTVTD TPME VVDIFRKLGL
Sbjct: 663 QRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLSPFTVTDHTPMETVVDIFRKLGL 722

Query: 779 RQCLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN 816
           RQCLVT +GRLLGIITKKDVL+H+AQMANQDP+SI+FN
Sbjct: 723 RQCLVTRSGRLLGIITKKDVLRHMAQMANQDPESIMFN 760


>gi|55770840 chloride channel 3 isoform e [Homo sapiens]
          Length = 866

 Score = 1226 bits (3172), Expect = 0.0
 Identities = 583/800 (72%), Positives = 682/800 (85%), Gaps = 4/800 (0%)

Query: 10  NRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGEDKSY---NGGGIGS 66
           +RG+ + S++S  ++SSDE+L+D     MDF   +D   LD +      Y   NGG I S
Sbjct: 8   HRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMTNGGSINS 67

Query: 67  SNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFS 126
           S  ++D L+EPIPGVGTYDDF+TIDWVREK +DR+RHR I +K KES W +  S+ DA+S
Sbjct: 68  STHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWS 127

Query: 127 GWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKC 186
           GWL++ L GL SG+LAGLIDI+A WMTDLKEGIC    W+NHE CCW S   TFEERDKC
Sbjct: 128 GWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKC 187

Query: 187 PEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTI 246
           P+W +W++LII   EG  +YI+NY MY+ WAL FAFLAVSLVKVFAPYACGSGIPEIKTI
Sbjct: 188 PQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTI 247

Query: 247 LSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNE 306
           LSGFIIRGYLGKWTL+IKTITLVLAV+SGLSLGKEGPLVHVACCCGNI  + F KY  NE
Sbjct: 248 LSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNE 307

Query: 307 AKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSIN 366
           AK+REVLSAA+AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAF LRSIN
Sbjct: 308 AKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSIN 367

Query: 367 PFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYP 426
           PFGNSRLVLFYVE+HTPW+LFEL PFILLG+FGGLWGA FIR NIAWCR+RK+T+ GKYP
Sbjct: 368 PFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYP 427

Query: 427 VIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSK-GGEL 485
           V+EV++V AITA++AFPN YTR++TSELI ELF DCG L+SS LCDY N  N SK   ++
Sbjct: 428 VLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDI 487

Query: 486 PDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQ 545
           PDRPAG+GVYSA+WQL L LI KI++T+FTFG+K+PSGLFIPSMA+GAIAGR++G+ +EQ
Sbjct: 488 PDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQ 547

Query: 546 LAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYI 605
           LAYYH +W +F  WC  GADCITPGLYAMVGAAACLGGVTRMTVSLVVI+FELTGGLEYI
Sbjct: 548 LAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYI 607

Query: 606 VPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLL 665
           VPLMAA MTSKWV DA GREGIY+AHIRLNGYPFL+AKEEF H TLA DVM+PRRNDP L
Sbjct: 608 VPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRNDPPL 667

Query: 666 TVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVV 725
            VLTQD+MTV+D+E +I+ET+Y+GFPV++S+ESQRLVGF LRRDL I+IE+ARKKQ+G+V
Sbjct: 668 AVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGIV 727

Query: 726 STSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTH 785
            +S + F +H+P LP  +P  LKLR+ILD+SPFTVTD TPMEIVVDIFRKLGLRQCLVTH
Sbjct: 728 GSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTH 787

Query: 786 NGRLLGIITKKDVLKHIAQM 805
           NG +LGIITKK++L+H+ Q+
Sbjct: 788 NGIVLGIITKKNILEHLEQL 807


>gi|167466160 chloride channel 7 isoform b [Homo sapiens]
          Length = 781

 Score =  261 bits (667), Expect = 2e-69
 Identities = 217/731 (29%), Positives = 352/731 (48%), Gaps = 124/731 (16%)

Query: 128 WLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCP 187
           W++  LIG+L+G +A  IDI    +  LK  +  G                     DK  
Sbjct: 103 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNI-------------------DK-- 141

Query: 188 EWNSWSQLIISTDEGAFAYIVNYFMYVLWALL---FAFLAVSLVKVFAPYACGSGIPEIK 244
                      T++G  +     F  +LWA L   F  +   +V    P A GSGIP+IK
Sbjct: 142 ----------FTEKGGLS-----FSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIK 186

Query: 245 TILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFN---- 300
             L+G  I   +   TLVIK   ++L+V  GL++GKEGP++H     G+++    +    
Sbjct: 187 CFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIH----SGSVIAAGISQGRS 242

Query: 301 ----------KYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWR 350
                     +Y + + ++R+ +SA AAAGVS AFGAP+GGVLFSLEE + ++     WR
Sbjct: 243 TSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWR 302

Query: 351 SFFAALVAAFTLRSINPFGNSRL-------VLFYVEFHT---PWHLFELVPFILLGIFGG 400
            FFA++++ FTL  +    +  +       ++ +  F +    + + E+  FI +G+ GG
Sbjct: 303 IFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGG 362

Query: 401 LWGALFIRTNIAWCRKRKTTQLGK--YPVIEVLVVTAITAILAFPNEYTRMSTSELIS-- 456
           + GA+F   N  W    +   + +    VIE ++V A+TA +AF   Y+      L    
Sbjct: 363 VLGAVFNALNY-WLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGS 421

Query: 457 -----ELFNDCGLLDSSKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVI 511
                +LF   G  +S         FNT +   +       G Y+ +  L L  ++   +
Sbjct: 422 MSYPLQLFCADGEYNSMAAA----FFNTPEKSVVSLFHDPPGSYNPL-TLGLFTLVYFFL 476

Query: 512 TIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGL 571
             +T+G+ + +G+FIPS+ +GA  GRL G+ +              S+ +  A    PG 
Sbjct: 477 ACWTYGLTVSAGVFIPSLLIGAAWGRLFGISL--------------SYLTGAAIWADPGK 522

Query: 572 YAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAH 631
           YA++GAAA LGG+ RMT+SL VIM E T  + Y  P+M   MT+K V D    EG+YD H
Sbjct: 523 YALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVF-IEGLYDMH 581

Query: 632 IRLNGYPFLEAKEEF-AHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISET--TYS 688
           I+L   PFL  +    +H   A +VM    + P+  +  ++ + V  +  ++S+T   ++
Sbjct: 582 IQLQSVPFLHWEAPVTSHSLTAREVM----STPVTCLRRREKVGV--IVDVLSDTASNHN 635

Query: 689 GFPVVV---SRESQRLVGFVLRRDLIISIEN---ARKKQDGVVSTSIIY--FTEHSPPLP 740
           GFPVV      +  RL G +LR  LI+ +++     +   G+V   +    F +  P  P
Sbjct: 636 GFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFP 695

Query: 741 PY---------TPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHN-GRLL 790
           P             T+ L   ++ SP+TV     +  V  +FR LGLR  +V  N  +++
Sbjct: 696 PIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVV 755

Query: 791 GIITKKDVLKH 801
           G++T+KD+ ++
Sbjct: 756 GLVTRKDLARY 766


>gi|14149607 chloride channel 7 isoform a [Homo sapiens]
          Length = 805

 Score =  261 bits (667), Expect = 2e-69
 Identities = 217/731 (29%), Positives = 352/731 (48%), Gaps = 124/731 (16%)

Query: 128 WLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCP 187
           W++  LIG+L+G +A  IDI    +  LK  +  G                     DK  
Sbjct: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNI-------------------DK-- 165

Query: 188 EWNSWSQLIISTDEGAFAYIVNYFMYVLWALL---FAFLAVSLVKVFAPYACGSGIPEIK 244
                      T++G  +     F  +LWA L   F  +   +V    P A GSGIP+IK
Sbjct: 166 ----------FTEKGGLS-----FSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIK 210

Query: 245 TILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFN---- 300
             L+G  I   +   TLVIK   ++L+V  GL++GKEGP++H     G+++    +    
Sbjct: 211 CFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIH----SGSVIAAGISQGRS 266

Query: 301 ----------KYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWR 350
                     +Y + + ++R+ +SA AAAGVS AFGAP+GGVLFSLEE + ++     WR
Sbjct: 267 TSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWR 326

Query: 351 SFFAALVAAFTLRSINPFGNSRL-------VLFYVEFHT---PWHLFELVPFILLGIFGG 400
            FFA++++ FTL  +    +  +       ++ +  F +    + + E+  FI +G+ GG
Sbjct: 327 IFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGG 386

Query: 401 LWGALFIRTNIAWCRKRKTTQLGK--YPVIEVLVVTAITAILAFPNEYTRMSTSELIS-- 456
           + GA+F   N  W    +   + +    VIE ++V A+TA +AF   Y+      L    
Sbjct: 387 VLGAVFNALNY-WLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGS 445

Query: 457 -----ELFNDCGLLDSSKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVI 511
                +LF   G  +S         FNT +   +       G Y+ +  L L  ++   +
Sbjct: 446 MSYPLQLFCADGEYNSMAAA----FFNTPEKSVVSLFHDPPGSYNPL-TLGLFTLVYFFL 500

Query: 512 TIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGL 571
             +T+G+ + +G+FIPS+ +GA  GRL G+ +              S+ +  A    PG 
Sbjct: 501 ACWTYGLTVSAGVFIPSLLIGAAWGRLFGISL--------------SYLTGAAIWADPGK 546

Query: 572 YAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAH 631
           YA++GAAA LGG+ RMT+SL VIM E T  + Y  P+M   MT+K V D    EG+YD H
Sbjct: 547 YALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVF-IEGLYDMH 605

Query: 632 IRLNGYPFLEAKEEF-AHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISET--TYS 688
           I+L   PFL  +    +H   A +VM    + P+  +  ++ + V  +  ++S+T   ++
Sbjct: 606 IQLQSVPFLHWEAPVTSHSLTAREVM----STPVTCLRRREKVGV--IVDVLSDTASNHN 659

Query: 689 GFPVVV---SRESQRLVGFVLRRDLIISIEN---ARKKQDGVVSTSIIY--FTEHSPPLP 740
           GFPVV      +  RL G +LR  LI+ +++     +   G+V   +    F +  P  P
Sbjct: 660 GFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFP 719

Query: 741 PY---------TPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHN-GRLL 790
           P             T+ L   ++ SP+TV     +  V  +FR LGLR  +V  N  +++
Sbjct: 720 PIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVV 779

Query: 791 GIITKKDVLKH 801
           G++T+KD+ ++
Sbjct: 780 GLVTRKDLARY 790


>gi|156104869 chloride channel 2 [Homo sapiens]
          Length = 898

 Score =  224 bits (572), Expect = 2e-58
 Identities = 174/558 (31%), Positives = 269/558 (48%), Gaps = 47/558 (8%)

Query: 186 CPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKT 245
           C +   W    ++T     + ++ Y  +V + ++    +    ++ AP A GSGIPE+KT
Sbjct: 115 CLQAQQWMSRGLNT-----SILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKT 169

Query: 246 ILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNIL---CHCFNKY 302
           IL G +++ YL   T + K I L  A+ SG+ LGKEGP VH+A  C  +L      F   
Sbjct: 170 ILRGVVLKEYLTLKTFIAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGI 229

Query: 303 RKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTL 362
            +NE++  E+L+AA A GV   F APIGGVLFS+E  S +F ++  WR FFAA  +AF  
Sbjct: 230 YENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIF 289

Query: 363 RSI---NPFGNSRLVLFYVEFHT--PWHLFELVPFILLGIFGGLWGALFIRTN---IAWC 414
           R +   N    +   LF   F    P+ L EL  F ++GI  G  GALF+  N   +   
Sbjct: 290 RVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVM 349

Query: 415 RKRKTTQ--LGKYPVIEVLVVTAITAILAFPNEY-----TRMSTSELISELFNDCGLLDS 467
           RK+KT    L +  ++   +VT + + L FP  +      ++S  E +  LF++   +  
Sbjct: 350 RKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTWVRQ 409

Query: 468 SKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIP 527
             + + E   +TS+    P         +    L + +++K  ++     + +P G F+P
Sbjct: 410 GLVEELEPP-STSQAWNPPRA-------NVFLTLVIFILMKFWMSALATTIPVPCGAFMP 461

Query: 528 SMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRM 587
              +GA  GRL+G  M         W             I PG YA+VGAAA  G VT  
Sbjct: 462 VFVIGAAFGRLVGESM-------AAWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTH- 513

Query: 588 TVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFA 647
           TVS  VI+FELTG + +I+P+M A + +  VA +L +  +YD+ IR+   P+L       
Sbjct: 514 TVSTAVIVFELTGQIAHILPVMIAVILANAVAQSL-QPSLYDSIIRIKKLPYLPELGWGR 572

Query: 648 HKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLR 707
           H+   + V      D     L   S T  D+   +  T      +V S ES  L+G + R
Sbjct: 573 HQQYRVRVEDIMVRDVPHVAL---SCTFRDLRLALHRTKGRMLALVESPESMILLGSIER 629

Query: 708 RDLI----ISIENARKKQ 721
             ++      +  AR++Q
Sbjct: 630 SQVVALLGAQLSPARRRQ 647



 Score = 37.0 bits (84), Expect = 0.074
 Identities = 19/50 (38%), Positives = 29/50 (58%)

Query: 753 LDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHI 802
           +D +PF + + T +     IF  LG+    VT  GRL+GI+T K++ K I
Sbjct: 790 IDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAI 839


>gi|4502873 chloride channel 6 isoform ClC-6a [Homo sapiens]
          Length = 869

 Score =  221 bits (563), Expect = 2e-57
 Identities = 187/587 (31%), Positives = 283/587 (48%), Gaps = 83/587 (14%)

Query: 218 LLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLS 277
           L F FLA SL+ +  P A GSGIPE+K  L+G  + G +   TL+ K + ++ +V+ GL 
Sbjct: 138 LTFVFLA-SLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLF 196

Query: 278 LGKEGPLVHVACCCGNILCHC---------FN-KYRKNEAKRREVLSAAAAAGVSVAFGA 327
           +GKEGP++H     G  L            FN  Y +++  +R+ +SA AAAGV+ AFGA
Sbjct: 197 VGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGA 256

Query: 328 PIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLR------SINPFGNSRL--VLFYVE 379
           PIGG LFSLEE S ++     W+  F ++ A FTL           +G+ +L  +L + E
Sbjct: 257 PIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNFGE 316

Query: 380 FHTP--------WHLFELVPFILLGIFGGLWGALF--IRTNIAWCRKRKTTQLGK-YPVI 428
           F           W   +L  F+++G+ GGL GA F  +   +A  R R      K   V+
Sbjct: 317 FKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHPKPKLVRVL 376

Query: 429 EVLVVTAITAILAFP-----NEYTRMSTSELIS------ELFNDCGLLDSSKLC------ 471
           E L+V+ +T ++ F       E  +MS+S  I       ++  D      +  C      
Sbjct: 377 ESLLVSLVTTVVVFVASMVLGECRQMSSSSQIGNDSFQLQVTEDVNSSIKTFFCPNDTYN 436

Query: 472 DYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAV 531
           D    F   +   +       G +S +  LAL  +L  ++  +T+G+ +PSGLF+PS+  
Sbjct: 437 DMATLFFNPQESAILQLFHQDGTFSPV-TLALFFVLYFLLACWTYGISVPSGLFVPSLLC 495

Query: 532 GAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSL 591
           GA  GRL+               V  S+   G   I  G +A++GAAA LGGV RMT+SL
Sbjct: 496 GAAFGRLVA-------------NVLKSYIGLGH--IYSGTFALIGAAAFLGGVVRMTISL 540

Query: 592 VVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEF-AHKT 650
            VI+ E T  + Y +P+M   M +KW  D   + GIYD H+ L G P LE + E    K 
Sbjct: 541 TVILIESTNEITYGLPIMVTLMVAKWTGDFFNK-GIYDIHVGLRGVPLLEWETEVEMDKL 599

Query: 651 LAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVV---SRESQRLVGFVLR 707
            A D+M+P      LT +   +  ++ + +I+  T +  FPVV      E + + G  L 
Sbjct: 600 RASDIMEPN-----LTYVYPHT-RIQSLVSILRTTVHHAFPVVTENRGNEKEFMKGNQL- 652

Query: 708 RDLIISIENARKKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILD 754
                 I N  K +   + T      + S  +  Y  P+ +LRN+ D
Sbjct: 653 ------ISNNIKFKKSSILTRAGEQRKRSQSMKSY--PSSELRNMCD 691



 Score = 33.9 bits (76), Expect = 0.62
 Identities = 19/50 (38%), Positives = 30/50 (60%), Gaps = 1/50 (2%)

Query: 756 SPFTVTDLTPMEIVVDIFRKLGLRQC-LVTHNGRLLGIITKKDVLKHIAQ 804
           SPFTV+  T +  V ++FR +GLR   +V   G ++GIIT+ ++     Q
Sbjct: 810 SPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTYEFLQ 859


>gi|119433677 chloride channel 1, skeletal muscle [Homo sapiens]
          Length = 988

 Score =  209 bits (532), Expect = 8e-54
 Identities = 164/532 (30%), Positives = 256/532 (48%), Gaps = 62/532 (11%)

Query: 208 VNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTIT 267
           + + ++V + L+    +     + +P A GSGIPE+KTIL G +++ YL     V K + 
Sbjct: 159 LQFLVWVTFPLVLILFSALFCHLISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVA 218

Query: 268 LVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKY---RKNEAKRREVLSAAAAAGVSVA 324
           L   + SG+ +GKEGP VH+A  C  +L    + +    +      ++L+   A GV   
Sbjct: 219 LTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSVFCGVYEQPYYYSDILTVGCAVGVGCC 278

Query: 325 FGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRL---VLFYVEFH 381
           FG P+GGVLFS+E  S YF ++  WR FFAA  +AF  R +  +    +    LF   F 
Sbjct: 279 FGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFR 338

Query: 382 T--PWHLFELVPFILLGIFGGLWGALFI---RTNIAWCRKRKTTQ--LGKYPVIEVLVVT 434
              P+ L EL  F  +GI  GL GA+F+   R  +   RK K     L K+ ++   +VT
Sbjct: 339 MDFPFDLKELPAFAAIGICCGLLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGIVT 398

Query: 435 AITAILAFPNEYTRMSTSEL-----ISELFNDCGLLDSSKLCDYENRFNTSKGGELPDRP 489
            + A   FP    +    EL     IS LF              +N       G+    P
Sbjct: 399 FVIASFTFPPGMGQFMAGELMPREAISTLF--------------DNNTWVKHAGD----P 440

Query: 490 AGVGVYSAMW---------QLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLG 540
             +G  SA+W          + L  ++K  ++I    M IP G F+P   +GA  GRL+G
Sbjct: 441 ESLG-QSAVWIHPRVNVVIIIFLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVG 499

Query: 541 VGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTG 600
              E +A    +  +F+    +    I PG YA++GAAA  G V+  TVS  VI FELTG
Sbjct: 500 ---EIMAMLFPDGILFDDIIYK----ILPGGYAVIGAAALTGAVSH-TVSTAVICFELTG 551

Query: 601 GLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLE--AKEEFAHKTLAMDVMKP 658
            + +I+P+M A + +  VA +L +  +YD+ I++   P+L      + +  T+ ++ +  
Sbjct: 552 QIAHILPMMVAVILANMVAQSL-QPSLYDSIIQVKKLPYLPDLGWNQLSKYTIFVEDIMV 610

Query: 659 RRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDL 710
           R            S T  ++ T++  TT    P+V S++S  L+G V R +L
Sbjct: 611 RD-----VKFVSASYTYGELRTLLQTTTVKTLPLVDSKDSMILLGSVERSEL 657



 Score = 32.3 bits (72), Expect = 1.8
 Identities = 16/50 (32%), Positives = 27/50 (54%)

Query: 753 LDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHI 802
           +D SPF + + T +     +F  LGL    VT  G+L G++  +++ K I
Sbjct: 821 IDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEELQKAI 870


>gi|112382220 chloride channel Ka isoform 1 [Homo sapiens]
          Length = 687

 Score =  187 bits (475), Expect = 3e-47
 Identities = 174/646 (26%), Positives = 287/646 (44%), Gaps = 94/646 (14%)

Query: 205 AYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIK 264
           ++++ Y  + ++ +     +    +   P + GSGIPE+KT+L+G I+  YL       K
Sbjct: 88  SHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAK 147

Query: 265 TITL--VLAVSSGLSLGKEGPLVH----VACCCGNILCHCFNKYRKNEAKRREVLSAAAA 318
            + L   LA  S L LGK GP VH    +A   G +      +  +N++K+ E+L AAAA
Sbjct: 148 VVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYLGRVRTTTIGE-PENKSKQNEMLVAAAA 206

Query: 319 AGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSR---LVL 375
            GV+  F AP  GVLFS+E +S +F ++  WR FFAA   AF  R +  F + +     L
Sbjct: 207 VGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETITSL 266

Query: 376 FYVEFH--TPWHLFELVPFILLGIFGGLWGAL-------------FIRTNIAWCRKRKTT 420
           +   F    P+ L E+  F+ L   GG+ G L             FI+TN  +  K   T
Sbjct: 267 YKTSFRVDVPFDLPEIFFFVAL---GGICGVLSCAYLFCQRTFLSFIKTN-RYSSKLLAT 322

Query: 421 QLGKYPVIEVLVVTAITAILAFPNEY-----TRMSTSELISELFNDCGLLDSSKLCDYEN 475
               Y  +  L++ +IT    +P        +R+S  + +  LF++             +
Sbjct: 323 SKPVYSALATLLLASIT----YPPGVGHFLASRLSMKQHLDSLFDN-------------H 365

Query: 476 RFNTSKGGELPDRPAGVGVYSAMWQ-----------LALTLILKIVITIFTFGMKIPSGL 524
            +        P  P  +      W+           LA  L++K  + I    + +P+G 
Sbjct: 366 SWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGY 425

Query: 525 FIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGV 584
           F+P   +GA  GRLLG   E LA    E  V     +     I PG YA+ GAAA  G V
Sbjct: 426 FMPIFILGAAIGRLLG---EALAVAFPEGIVTGGVTNP----IMPGGYALAGAAAFSGAV 478

Query: 585 TRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLE--- 641
           T  T+S  ++ FELTG + + +P++ A + +  +A +  +   YD  I +   P+L    
Sbjct: 479 TH-TISTALLAFELTGQIVHALPVLMAVLAANAIAQSC-QPSFYDGTIIVKKLPYLPRIL 536

Query: 642 AKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRL 701
            +   +H       M     +  +T L +D+  +E+V  +++ T  + +P+V S ESQ L
Sbjct: 537 GRNIGSHHVRVEHFM-----NHSITTLAKDT-PLEEVVKVVTSTDVTEYPLVESTESQIL 590

Query: 702 VGFVLRRDLIISIENARKKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVT 761
           VG V R  L+ +++     +       +        P  P T               T+ 
Sbjct: 591 VGIVQRAQLVQALQAEPPSRAPGHQQCLQDILARGCPTEPVT--------------LTLF 636

Query: 762 DLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHIAQMAN 807
             T +    ++F+ L L+   VT  GR +G ++  ++ K I+ + N
Sbjct: 637 SETTLHQAQNLFKLLNLQSLFVTSRGRAVGCVSWVEMKKAISNLTN 682


>gi|112382222 chloride channel Ka isoform 2 [Homo sapiens]
          Length = 686

 Score =  186 bits (473), Expect = 6e-47
 Identities = 179/652 (27%), Positives = 293/652 (44%), Gaps = 107/652 (16%)

Query: 205 AYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIK 264
           ++++ Y  + ++ +     +    +   P + GSGIPE+KT+L+G I+  YL       K
Sbjct: 88  SHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAK 147

Query: 265 TITL--VLAVSSGLSLGKEGPLVH----VACCCGNILCHCFNKYRKNEAKRREVLSAAAA 318
            + L   LA  S L LGK GP VH    +A   G +      +  +N++K+ E+L AAAA
Sbjct: 148 VVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYLGRVRTTTIGE-PENKSKQNEMLVAAAA 206

Query: 319 AGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSR---LVL 375
            GV+  F AP  GVLFS+E +S +F ++  WR FFAA   AF  R +  F + +     L
Sbjct: 207 VGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETITSL 266

Query: 376 FYVEFH--TPWHLFELVPFILLGIFGGLWGAL-------------FIRTNIAWCRKRKTT 420
           +   F    P+ L E+  F+ L   GG+ G L             FI+TN  +  K   T
Sbjct: 267 YKTSFRVDVPFDLPEIFFFVAL---GGICGVLSCAYLFCQRTFLSFIKTN-RYSSKLLAT 322

Query: 421 QLGKYPVIEVLVVTAITAILAFPNEY-----TRMSTSELISELFNDCGLLDSSKLCDYEN 475
               Y  +  L++ +IT    +P        +R+S  + +  LF++             +
Sbjct: 323 SKPVYSALATLLLASIT----YPPGVGHFLASRLSMKQHLDSLFDN-------------H 365

Query: 476 RFNTSKGGELPDRPAGVGVYSAMWQ-----------LALTLILKIVITIFTFGMKIPSGL 524
            +        P  P  +      W+           LA  L++K  + I    + +P+G 
Sbjct: 366 SWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGY 425

Query: 525 FIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGV 584
           F+P   +GA  GRLLG   E LA    E  V     +     I PG YA+ GAAA  G V
Sbjct: 426 FMPIFILGAAIGRLLG---EALAVAFPEGIVTGGVTNP----IMPGGYALAGAAAFSGAV 478

Query: 585 TRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLE--- 641
           T  T+S  ++ FELTG + + +P++ A + +  +A +  +   YD  I +   P+L    
Sbjct: 479 TH-TISTALLAFELTGQIVHALPVLMAVLAANAIAQSC-QPSFYDGTIIVKKLPYLPRIL 536

Query: 642 AKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRL 701
            +   +H       M     +  +T L +D+  +E+V  +++ T  + +P+V S ESQ L
Sbjct: 537 GRNIGSHHVRVEHFM-----NHSITTLAKDT-PLEEVVKVVTSTDVTEYPLVESTESQIL 590

Query: 702 VGFVLRRDLIISIENARKKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNIL----DLSP 757
           VG V R  L+ +++                    + P P   P    L++IL       P
Sbjct: 591 VGIVQRAQLVQALQ--------------------AEP-PSRAPGHQCLQDILARGCPTEP 629

Query: 758 FTVT--DLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHIAQMAN 807
            T+T    T +    ++F+ L L+   VT  GR +G ++  ++ K I+ + N
Sbjct: 630 VTLTLFSETTLHQAQNLFKLLNLQSLFVTSRGRAVGCVSWVEMKKAISNLTN 681


>gi|155969705 chloride channel Kb [Homo sapiens]
          Length = 687

 Score =  186 bits (471), Expect = 1e-46
 Identities = 175/638 (27%), Positives = 282/638 (44%), Gaps = 78/638 (12%)

Query: 205 AYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIK 264
           ++++ Y  + ++ +     +    +   P + GSGIPE+KT+L+G ++  YL       K
Sbjct: 88  SHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEVKTMLAGVVLEDYLDIKNFGAK 147

Query: 265 TITL--VLAVSSGLSLGKEGPLVHV----ACCCGNILCHCFNKYRKNEAKRREVLSAAAA 318
            + L   LA  S L LGK GP VH+    A   G +      +  +N++K+ E+L AAAA
Sbjct: 148 VVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTTTIGE-PENKSKQNEMLVAAAA 206

Query: 319 AGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSR---LVL 375
            GV+  F AP  GVLFS+E +S +F +   WR FFAA   AF  R +  F + +     L
Sbjct: 207 VGVATVFAAPFSGVLFSIEVMSSHFSVWDYWRGFFAATCGAFMFRLLAVFNSEQETITSL 266

Query: 376 FYVEFH--TPWHLFELVPFILLGIFGGLWGAL----------FIRTNIAWCRKRKTTQLG 423
           +   F    P+ L E+  F+ LG   G+ G+           FIR N  +  K   T   
Sbjct: 267 YKTSFRVDVPFDLPEIFFFVALGGLCGILGSAYLFCQRIFFGFIRNN-RFSSKLLATSKP 325

Query: 424 KYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSKGG 483
            Y  +  LV+ +IT    +P    R   S L  +   D  L D+       + +      
Sbjct: 326 VYSALATLVLASIT----YPPSAGRFLASRLSMKQHLD-SLFDN-------HSWALMTQN 373

Query: 484 ELPDRPAGVGVYSAMWQ-----------LALTLILKIVITIFTFGMKIPSGLFIPSMAVG 532
             P  P  +      W+           LA  L++K  + I    + +P+G F+P    G
Sbjct: 374 SSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFVYG 433

Query: 533 AIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLV 592
           A  GRL G   E L++   E  V     +     I PG YA+ GAAA  G VT  T+S  
Sbjct: 434 AAIGRLFG---ETLSFIFPEGIVAGGITNP----IMPGGYALAGAAAFSGAVTH-TISTA 485

Query: 593 VIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLE---AKEEFAHK 649
           ++ FE+TG + + +P++ A + +  +A +  +   YD  + +   P+L     +   +H+
Sbjct: 486 LLAFEVTGQIVHALPVLMAVLAANAIAQSC-QPSFYDGTVIVKKLPYLPRILGRNIGSHR 544

Query: 650 TLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRD 709
                 M     +  +T L +D M +E+V  +++ T  + +P+V S ESQ LVG V R  
Sbjct: 545 VRVEHFM-----NHSITTLAKD-MPLEEVVKVVTSTDVAKYPLVESTESQILVGIVRRAQ 598

Query: 710 LIISIENARKKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIV 769
           L+ +++             +        P  P T         L LSP      T +   
Sbjct: 599 LVQALKAEPPSWAPGHQQCLQDILAAGCPTEPVT---------LKLSP-----ETSLHEA 644

Query: 770 VDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHIAQMAN 807
            ++F  L L    VT  GR +G ++  ++ K I+ + N
Sbjct: 645 HNLFELLNLHSLFVTSRGRAVGCVSWVEMKKAISNLTN 682


>gi|12025671 chloride channel 6 isoform ClC-6c [Homo sapiens]
          Length = 353

 Score =  108 bits (270), Expect = 2e-23
 Identities = 75/197 (38%), Positives = 105/197 (53%), Gaps = 27/197 (13%)

Query: 218 LLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLS 277
           L F FLA SL+ +  P A GSGIPE+K  L+G  + G +   TL+ K + ++ +V+ GL 
Sbjct: 138 LTFVFLA-SLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLF 196

Query: 278 LGKEGPLVHVACCCGNILCHC---------FN-KYRKNEAKRREVLSAAAAAGVSVAFGA 327
           +GKEGP++H     G  L            FN  Y +++  +R+ +SA AAAGV+ AFGA
Sbjct: 197 VGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGA 256

Query: 328 PIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTL---RSINPFGNSRLVLFYVEFHTPW 384
           PIGG LFSLEE S ++     W+  F ++ A FTL   RS   FG+             W
Sbjct: 257 PIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGS-------------W 303

Query: 385 HLFELVPFILLGIFGGL 401
             F+L   +  G F  L
Sbjct: 304 GSFQLPGLLNFGEFKSL 320


>gi|12025673 chloride channel 6 isoform ClC-6d [Homo sapiens]
          Length = 308

 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 32/75 (42%), Positives = 47/75 (62%), Gaps = 1/75 (1%)

Query: 218 LLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLS 277
           L F FLA SL+ +  P A GSGIPE+K  L+G  + G +   TL+ K + ++ +V+ GL 
Sbjct: 138 LTFVFLA-SLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLF 196

Query: 278 LGKEGPLVHVACCCG 292
           +GKEGP++H     G
Sbjct: 197 VGKEGPMIHSGSVVG 211


>gi|12025668 chloride channel 6 isoform ClC-6b [Homo sapiens]
          Length = 320

 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 32/75 (42%), Positives = 47/75 (62%), Gaps = 1/75 (1%)

Query: 218 LLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLS 277
           L F FLA SL+ +  P A GSGIPE+K  L+G  + G +   TL+ K + ++ +V+ GL 
Sbjct: 138 LTFVFLA-SLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLF 196

Query: 278 LGKEGPLVHVACCCG 292
           +GKEGP++H     G
Sbjct: 197 VGKEGPMIHSGSVVG 211


>gi|5032033 RNA binding motif protein 6 [Homo sapiens]
          Length = 1123

 Score = 33.9 bits (76), Expect = 0.62
 Identities = 35/123 (28%), Positives = 56/123 (45%), Gaps = 24/123 (19%)

Query: 8   MDNRGFQQGSFSSFQNSS-SDEDLMDIPATAMDFSMRD----DVPPLDREVGE------- 55
           +D R  +Q S S F+N   SD D  D   T +DF  R     D+   DR+          
Sbjct: 203 LDFRAREQ-SRSDFRNRDVSDLDFRDKDGTQVDFRGRGSGTTDLDFRDRDTPHSDFRGRH 261

Query: 56  ----DKSYNGGGIGSSNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSK 111
               D+ + G  +GS    M+F +  +P V    D N +D+++  ++DR+      N+ +
Sbjct: 262 RSRTDQDFRGREMGSC---MEFKDREMPPV----DPNILDYIQPSTQDREHSGMNVNRRE 314

Query: 112 EST 114
           EST
Sbjct: 315 EST 317


>gi|38787991 transmembrane 4 superfamily member 8 isoform 2 [Homo
           sapiens]
          Length = 228

 Score = 30.8 bits (68), Expect = 5.3
 Identities = 12/41 (29%), Positives = 24/41 (58%), Gaps = 2/41 (4%)

Query: 57  KSYNGGGIGSSNRIMDFLEEPIP--GVGTYDDFNTIDWVRE 95
           K+YNG    +++R +D+++  +   G+  Y D+   DW +E
Sbjct: 99  KTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKE 139


>gi|5032201 transmembrane 4 superfamily member 8 isoform 1 [Homo
           sapiens]
          Length = 253

 Score = 30.8 bits (68), Expect = 5.3
 Identities = 12/41 (29%), Positives = 24/41 (58%), Gaps = 2/41 (4%)

Query: 57  KSYNGGGIGSSNRIMDFLEEPIP--GVGTYDDFNTIDWVRE 95
           K+YNG    +++R +D+++  +   G+  Y D+   DW +E
Sbjct: 124 KTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKE 164


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.139    0.432 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,978,691
Number of Sequences: 37866
Number of extensions: 1297814
Number of successful extensions: 3637
Number of sequences better than 10.0: 20
Number of HSP's better than 10.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 3553
Number of HSP's gapped (non-prelim): 31
length of query: 816
length of database: 18,247,518
effective HSP length: 111
effective length of query: 705
effective length of database: 14,044,392
effective search space: 9901296360
effective search space used: 9901296360
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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