Search of human proteins with 187828880

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo
sapiens]
         (2261 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo s...  4595   0.0  
gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo s...  4561   0.0  
gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B ...  2693   0.0  
gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E...  2347   0.0  
gi|192807298 calcium channel, voltage-dependent, L type, alpha 1...   781   0.0  
gi|193788548 calcium channel, voltage-dependent, L type, alpha 1...   779   0.0  
gi|193794832 calcium channel, voltage-dependent, L type, alpha 1...   778   0.0  
gi|193788532 calcium channel, voltage-dependent, L type, alpha 1...   778   0.0  
gi|193788544 calcium channel, voltage-dependent, L type, alpha 1...   777   0.0  
gi|193788540 calcium channel, voltage-dependent, L type, alpha 1...   777   0.0  
gi|193788534 calcium channel, voltage-dependent, L type, alpha 1...   777   0.0  
gi|120433602 calcium channel, voltage-dependent, L type, alpha 1...   776   0.0  
gi|193788538 calcium channel, voltage-dependent, L type, alpha 1...   776   0.0  
gi|193794828 calcium channel, voltage-dependent, L type, alpha 1...   775   0.0  
gi|193788730 calcium channel, voltage-dependent, L type, alpha 1...   775   0.0  
gi|193788542 calcium channel, voltage-dependent, L type, alpha 1...   775   0.0  
gi|193788536 calcium channel, voltage-dependent, L type, alpha 1...   775   0.0  
gi|193788528 calcium channel, voltage-dependent, L type, alpha 1...   774   0.0  
gi|192807300 calcium channel, voltage-dependent, L type, alpha 1...   773   0.0  
gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D ...   773   0.0  
gi|193788530 calcium channel, voltage-dependent, L type, alpha 1...   773   0.0  
gi|193794830 calcium channel, voltage-dependent, L type, alpha 1...   769   0.0  
gi|193788526 calcium channel, voltage-dependent, L type, alpha 1...   769   0.0  
gi|193788732 calcium channel, voltage-dependent, L type, alpha 1...   766   0.0  
gi|193788728 calcium channel, voltage-dependent, L type, alpha 1...   765   0.0  
gi|53832007 calcium channel, voltage-dependent, L type, alpha 1F...   765   0.0  
gi|193788724 calcium channel, voltage-dependent, L type, alpha 1...   759   0.0  
gi|193788720 calcium channel, voltage-dependent, L type, alpha 1...   759   0.0  
gi|110349767 calcium channel, voltage-dependent, L type, alpha 1...   737   0.0  
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor...   327   6e-89

>gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo
            sapiens]
          Length = 2261

 Score = 4595 bits (11917), Expect = 0.0
 Identities = 2261/2261 (100%), Positives = 2261/2261 (100%)

Query: 1    MARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMA 60
            MARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMA
Sbjct: 1    MARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMA 60

Query: 61   LYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQH 120
            LYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQH
Sbjct: 61   LYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQH 120

Query: 121  LPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTG 180
            LPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTG
Sbjct: 121  LPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTG 180

Query: 181  ILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIF 240
            ILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIF
Sbjct: 181  ILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIF 240

Query: 241  AIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQ 300
            AIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQ
Sbjct: 241  AIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQ 300

Query: 301  FDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLS 360
            FDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLS
Sbjct: 301  FDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLS 360

Query: 361  GEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGA 420
            GEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGA
Sbjct: 361  GEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGA 420

Query: 421  LRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYI 480
            LRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYI
Sbjct: 421  LRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYI 480

Query: 481  RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG 540
            RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG
Sbjct: 481  RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG 540

Query: 541  LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL 600
            LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL
Sbjct: 541  LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL 600

Query: 601  RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMT 660
            RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMT
Sbjct: 601  RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMT 660

Query: 661  VFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANA 720
            VFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANA
Sbjct: 661  VFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANA 720

Query: 721  QELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTS 780
            QELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTS
Sbjct: 721  QELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTS 780

Query: 781  EMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQENRNNNTNKSR 840
            EMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQENRNNNTNKSR
Sbjct: 781  EMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQENRNNNTNKSR 840

Query: 841  AAEPTVDQRLGQQRAEDFLRKQARYHDRARDPSGSAGLDARRPWAGSQEAELSREGPYGR 900
            AAEPTVDQRLGQQRAEDFLRKQARYHDRARDPSGSAGLDARRPWAGSQEAELSREGPYGR
Sbjct: 841  AAEPTVDQRLGQQRAEDFLRKQARYHDRARDPSGSAGLDARRPWAGSQEAELSREGPYGR 900

Query: 901  ESDHHAREGSLEQPGFWEGEAERGKAGDPHRRHVHRQGGSRESRSGSPRTGADGEHRRHR 960
            ESDHHAREGSLEQPGFWEGEAERGKAGDPHRRHVHRQGGSRESRSGSPRTGADGEHRRHR
Sbjct: 901  ESDHHAREGSLEQPGFWEGEAERGKAGDPHRRHVHRQGGSRESRSGSPRTGADGEHRRHR 960

Query: 961  AHRRPGEEGPEDKAERRARHREGSRPARGGEGEGEGPDGGERRRRHRHGAPATYEGDARR 1020
            AHRRPGEEGPEDKAERRARHREGSRPARGGEGEGEGPDGGERRRRHRHGAPATYEGDARR
Sbjct: 961  AHRRPGEEGPEDKAERRARHREGSRPARGGEGEGEGPDGGERRRRHRHGAPATYEGDARR 1020

Query: 1021 EDKERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAEDIDNMKNNKLATAESA 1080
            EDKERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAEDIDNMKNNKLATAESA
Sbjct: 1021 EDKERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAEDIDNMKNNKLATAESA 1080

Query: 1081 APHGSLGHAGLPQSPAKMGNSTDPGPMLAIPAMATNPQNAASRRTPNNPGNPSNPGPPKT 1140
            APHGSLGHAGLPQSPAKMGNSTDPGPMLAIPAMATNPQNAASRRTPNNPGNPSNPGPPKT
Sbjct: 1081 APHGSLGHAGLPQSPAKMGNSTDPGPMLAIPAMATNPQNAASRRTPNNPGNPSNPGPPKT 1140

Query: 1141 PENSLIVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEE 1200
            PENSLIVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEE
Sbjct: 1141 PENSLIVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEE 1200

Query: 1201 EKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIA 1260
            EKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIA
Sbjct: 1201 EKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIA 1260

Query: 1261 LAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIV 1320
            LAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIV
Sbjct: 1261 LAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIV 1320

Query: 1321 VSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNI 1380
            VSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNI
Sbjct: 1321 VSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNI 1380

Query: 1381 LIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKYE 1440
            LIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKYE
Sbjct: 1381 LIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKYE 1440

Query: 1441 FHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPF 1500
            FHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPF
Sbjct: 1441 FHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPF 1500

Query: 1501 FFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMW 1560
            FFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMW
Sbjct: 1501 FFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMW 1560

Query: 1561 QFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAF 1620
            QFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAF
Sbjct: 1561 QFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAF 1620

Query: 1621 GILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRI 1680
            GILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRI
Sbjct: 1621 GILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRI 1680

Query: 1681 LLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFR 1740
            LLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFR
Sbjct: 1681 LLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFR 1740

Query: 1741 TFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSF 1800
            TFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSF
Sbjct: 1741 TFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSF 1800

Query: 1801 LMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVIS 1860
            LMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVIS
Sbjct: 1801 LMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVIS 1860

Query: 1861 PPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMD 1920
            PPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMD
Sbjct: 1861 PPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMD 1920

Query: 1921 AELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREE 1980
            AELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREE
Sbjct: 1921 AELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREE 1980

Query: 1981 QDRTPLMFQRMEPPSPTQEGGPGQNALPSTQLDPGGALMAHESGLKESPSWVTQRAQEMF 2040
            QDRTPLMFQRMEPPSPTQEGGPGQNALPSTQLDPGGALMAHESGLKESPSWVTQRAQEMF
Sbjct: 1981 QDRTPLMFQRMEPPSPTQEGGPGQNALPSTQLDPGGALMAHESGLKESPSWVTQRAQEMF 2040

Query: 2041 QKTGTWSPEQGPPTDMPNSQPNSQSVEMREMGRDGYSDSEHYLPMEGQGRAASMPRLPAE 2100
            QKTGTWSPEQGPPTDMPNSQPNSQSVEMREMGRDGYSDSEHYLPMEGQGRAASMPRLPAE
Sbjct: 2041 QKTGTWSPEQGPPTDMPNSQPNSQSVEMREMGRDGYSDSEHYLPMEGQGRAASMPRLPAE 2100

Query: 2101 NQRRRGRPRGNNLSTISDTSPMKRSASVLGPKARRLDDYSLERVPPEENQRHHQRRRDRS 2160
            NQRRRGRPRGNNLSTISDTSPMKRSASVLGPKARRLDDYSLERVPPEENQRHHQRRRDRS
Sbjct: 2101 NQRRRGRPRGNNLSTISDTSPMKRSASVLGPKARRLDDYSLERVPPEENQRHHQRRRDRS 2160

Query: 2161 HRASERSLGRYTDVDTGLGTDLSMTTQSGDLPSKERDQERGRPKDRKHRQHHHHHHHHHH 2220
            HRASERSLGRYTDVDTGLGTDLSMTTQSGDLPSKERDQERGRPKDRKHRQHHHHHHHHHH
Sbjct: 2161 HRASERSLGRYTDVDTGLGTDLSMTTQSGDLPSKERDQERGRPKDRKHRQHHHHHHHHHH 2220

Query: 2221 PPPPDKDRYAQERPDHGRARARDQRWSRSPSEGREHMAHRQ 2261
            PPPPDKDRYAQERPDHGRARARDQRWSRSPSEGREHMAHRQ
Sbjct: 2221 PPPPDKDRYAQERPDHGRARARDQRWSRSPSEGREHMAHRQ 2261


>gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo
            sapiens]
          Length = 2506

 Score = 4561 bits (11831), Expect = 0.0
 Identities = 2250/2261 (99%), Positives = 2253/2261 (99%), Gaps = 1/2261 (0%)

Query: 1    MARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMA 60
            MARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMA
Sbjct: 1    MARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMA 60

Query: 61   LYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQH 120
            LYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQH
Sbjct: 61   LYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQH 120

Query: 121  LPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTG 180
            LPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTG
Sbjct: 121  LPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTG 180

Query: 181  ILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIF 240
            ILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIF
Sbjct: 181  ILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIF 240

Query: 241  AIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQ 300
            AIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQ
Sbjct: 241  AIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQ 300

Query: 301  FDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLS 360
            FDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLS
Sbjct: 301  FDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLS 360

Query: 361  GEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGA 420
            GEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFD A
Sbjct: 361  GEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFD-A 419

Query: 421  LRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYI 480
            LRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYI
Sbjct: 420  LRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYI 479

Query: 481  RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG 540
            RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG
Sbjct: 480  RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG 539

Query: 541  LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL 600
            LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL
Sbjct: 540  LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL 599

Query: 601  RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMT 660
            RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMT
Sbjct: 600  RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMT 659

Query: 661  VFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANA 720
            VFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANA
Sbjct: 660  VFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANA 719

Query: 721  QELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTS 780
            QELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTS
Sbjct: 720  QELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTS 779

Query: 781  EMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQENRNNNTNKSR 840
            EMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQENRNNNTNKSR
Sbjct: 780  EMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQENRNNNTNKSR 839

Query: 841  AAEPTVDQRLGQQRAEDFLRKQARYHDRARDPSGSAGLDARRPWAGSQEAELSREGPYGR 900
            AAEPTVDQRLGQQRAEDFLRKQARYHDRARDPSGSAGLDARRPWAGSQEAELSREGPYGR
Sbjct: 840  AAEPTVDQRLGQQRAEDFLRKQARYHDRARDPSGSAGLDARRPWAGSQEAELSREGPYGR 899

Query: 901  ESDHHAREGSLEQPGFWEGEAERGKAGDPHRRHVHRQGGSRESRSGSPRTGADGEHRRHR 960
            ESDHHAREGSLEQPGFWEGEAERGKAGDPHRRHVHRQGGSRESRSGSPRTGADGEHRRHR
Sbjct: 900  ESDHHAREGSLEQPGFWEGEAERGKAGDPHRRHVHRQGGSRESRSGSPRTGADGEHRRHR 959

Query: 961  AHRRPGEEGPEDKAERRARHREGSRPARGGEGEGEGPDGGERRRRHRHGAPATYEGDARR 1020
            AHRRPGEEGPEDKAERRARHREGSRPARGGEGEGEGPDGGERRRRHRHGAPATYEGDARR
Sbjct: 960  AHRRPGEEGPEDKAERRARHREGSRPARGGEGEGEGPDGGERRRRHRHGAPATYEGDARR 1019

Query: 1021 EDKERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAEDIDNMKNNKLATAESA 1080
            EDKERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAEDIDNMKNNKLATAESA
Sbjct: 1020 EDKERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAEDIDNMKNNKLATAESA 1079

Query: 1081 APHGSLGHAGLPQSPAKMGNSTDPGPMLAIPAMATNPQNAASRRTPNNPGNPSNPGPPKT 1140
            APHGSLGHAGLPQSPAKMGNSTDPGPMLAIPAMATNPQNAASRRTPNNPGNPSNPGPPKT
Sbjct: 1080 APHGSLGHAGLPQSPAKMGNSTDPGPMLAIPAMATNPQNAASRRTPNNPGNPSNPGPPKT 1139

Query: 1141 PENSLIVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEE 1200
            PENSLIVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEE
Sbjct: 1140 PENSLIVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEE 1199

Query: 1201 EKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIA 1260
            EKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIA
Sbjct: 1200 EKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIA 1259

Query: 1261 LAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIV 1320
            LAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIV
Sbjct: 1260 LAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIV 1319

Query: 1321 VSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNI 1380
            VSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNI
Sbjct: 1320 VSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNI 1379

Query: 1381 LIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKYE 1440
            LIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKYE
Sbjct: 1380 LIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKYE 1439

Query: 1441 FHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPF 1500
            FHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPF
Sbjct: 1440 FHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPF 1499

Query: 1501 FFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMW 1560
            FFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMW
Sbjct: 1500 FFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMW 1559

Query: 1561 QFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAF 1620
            QFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAF
Sbjct: 1560 QFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAF 1619

Query: 1621 GILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRI 1680
            GILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRI
Sbjct: 1620 GILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRI 1679

Query: 1681 LLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFR 1740
            LLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFR
Sbjct: 1680 LLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFR 1739

Query: 1741 TFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSF 1800
            TFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSF
Sbjct: 1740 TFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSF 1799

Query: 1801 LMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVIS 1860
            LMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAA GR+ Y DMY +LR +S
Sbjct: 1800 LMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMS 1859

Query: 1861 PPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMD 1920
            PPLGLGKKCP RVA KRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMD
Sbjct: 1860 PPLGLGKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMD 1919

Query: 1921 AELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREE 1980
            AELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREE
Sbjct: 1920 AELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREE 1979

Query: 1981 QDRTPLMFQRMEPPSPTQEGGPGQNALPSTQLDPGGALMAHESGLKESPSWVTQRAQEMF 2040
            QDRTPLMFQRMEPPSPTQEGGPGQNALPSTQLDPGGALMAHESGLKESPSWVTQRAQEMF
Sbjct: 1980 QDRTPLMFQRMEPPSPTQEGGPGQNALPSTQLDPGGALMAHESGLKESPSWVTQRAQEMF 2039

Query: 2041 QKTGTWSPEQGPPTDMPNSQPNSQSVEMREMGRDGYSDSEHYLPMEGQGRAASMPRLPAE 2100
            QKTGTWSPEQGPPTDMPNSQPNSQSVEMREMGRDGYSDSEHYLPMEGQGRAASMPRLPAE
Sbjct: 2040 QKTGTWSPEQGPPTDMPNSQPNSQSVEMREMGRDGYSDSEHYLPMEGQGRAASMPRLPAE 2099

Query: 2101 NQRRRGRPRGNNLSTISDTSPMKRSASVLGPKARRLDDYSLERVPPEENQRHHQRRRDRS 2160
            NQRRRGRPRGNNLSTISDTSPMKRSASVLGPKARRLDDYSLERVPPEENQRHHQRRRDRS
Sbjct: 2100 NQRRRGRPRGNNLSTISDTSPMKRSASVLGPKARRLDDYSLERVPPEENQRHHQRRRDRS 2159

Query: 2161 HRASERSLGRYTDVDTGLGTDLSMTTQSGDLPSKERDQERGRPKDRKHRQHHHHHHHHHH 2220
            HRASERSLGRYTDVDTGLGTDLSMTTQSGDLPSKERDQERGRPKDRKHRQHHHHHHHHHH
Sbjct: 2160 HRASERSLGRYTDVDTGLGTDLSMTTQSGDLPSKERDQERGRPKDRKHRQHHHHHHHHHH 2219

Query: 2221 PPPPDKDRYAQERPDHGRARARDQRWSRSPSEGREHMAHRQ 2261
            PPPPDKDRYAQERPDHGRARARDQRWSRSPSEGREHMAHRQ
Sbjct: 2220 PPPPDKDRYAQERPDHGRARARDQRWSRSPSEGREHMAHRQ 2260



 Score = 39.7 bits (91), Expect = 0.034
 Identities = 83/380 (21%), Positives = 126/380 (33%), Gaps = 79/380 (20%)

Query: 825  VVDPQENRNNNTNKSRAAEPTVDQRLGQQRAEDFLRKQARYHDRARDPSGSAGLDARRPW 884
            V+ P+  R ++ +  R   P  +QR  Q+R +   R   R   R  D     G D     
Sbjct: 2127 VLGPKARRLDDYSLERVP-PEENQRHHQRRRDRSHRASERSLGRYTDVDTGLGTDLSMTT 2185

Query: 885  AGSQEAELSREGPYGRESD-----------HHAREGSLEQPGFWEGEAERGKAG------ 927
                     R+   GR  D           HH      ++  + +   + G+A       
Sbjct: 2186 QSGDLPSKERDQERGRPKDRKHRQHHHHHHHHHHPPPPDKDRYAQERPDHGRARARDQRW 2245

Query: 928  ----DPHRRHV-HRQGGSRESRSGSPRTGADGEHRRHRAH------------------RR 964
                   R H+ HRQG S  S S +P T      RR R                    R+
Sbjct: 2246 SRSPSEGREHMAHRQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPSTPRPHVSYSPVIRK 2305

Query: 965  PGEEGPEDKAERRARHREGSRPARGGEGEGEGPD----------GGERRRRHRHGAPATY 1014
             G  GP  + +++ + ++    AR G     GP            G+R     H +  + 
Sbjct: 2306 AGGSGPPQQQQQQQQQQQQQAVARPGRAATSGPRRYPGPTAEPLAGDRPPTGGHSSGRSP 2365

Query: 1015 EGDARREDKERRHRRRK-ENQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAEDIDNMKN-- 1071
              + R     R    R   + G+  P SGP++S   P  +  G       ++ D   +  
Sbjct: 2366 RMERRVPGPARSESPRACRHGGARWPASGPHVSEGPPGPRHHGYYRGSDYDEADGPGSGG 2425

Query: 1072 --NKLATAESAAP---HGSLGHAG-LPQSPAKMGNSTDPGPMLAIPAMATNPQNAASRRT 1125
                +A A  A P   H S G  G  P++P   G           PA A+  ++   RR 
Sbjct: 2426 GEEAMAGAYDAPPPVRHASSGATGRSPRTPRASG-----------PACASPSRH--GRRL 2472

Query: 1126 PN------NPGNPSNPGPPK 1139
            PN          P  PG  K
Sbjct: 2473 PNGYYPAHGLARPRGPGSRK 2492


>gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B
            subunit [Homo sapiens]
          Length = 2339

 Score = 2693 bits (6980), Expect = 0.0
 Identities = 1458/2301 (63%), Positives = 1671/2301 (72%), Gaps = 178/2301 (7%)

Query: 1    MARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQGG-QPGAQRMYKQSMAQRARTM 59
            M RFGDE+  RYGG G G  A      GG  GAGG   GG QPG + +YKQS+AQRARTM
Sbjct: 1    MVRFGDELGGRYGGPGGGERAR----GGGAGGAGGPGPGGLQPGQRVLYKQSIAQRARTM 56

Query: 60   ALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQ 119
            ALYNPIPV+QNC TVNRSLF+FSEDNVVRKYAK+ITEWPPFEYMILATIIANCIVLALEQ
Sbjct: 57   ALYNPIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQ 116

Query: 120  HLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLT 179
            HLPD DKTPMSERLDDTEPYFIGIFCFEAGIKIIALGF FHKGSYLRNGWNVMDFVVVLT
Sbjct: 117  HLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLT 176

Query: 180  GILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILI 239
            GILAT GT+FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAM+PLLQIGLLLFFAIL+
Sbjct: 177  GILATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILM 236

Query: 240  FAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGIT 299
            FAIIGLEFYMGKFH  CF   TD  +     PCG E PAR C   T+C+ YW GPN GIT
Sbjct: 237  FAIIGLEFYMGKFHKACFPNSTD-AEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGIT 295

Query: 300  QFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVL 359
             FDNILFA+LTVFQCITMEGWTD+LYN+NDA+GNTWNWLYFIPLIIIGSFFMLNLVLGVL
Sbjct: 296  NFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVL 355

Query: 360  SGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDG 419
            SGEFAKERERVENRRAFLKLRRQQQIERELNGY+EWI KAEEV+LAE++ + E++ P D 
Sbjct: 356  SGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLD- 414

Query: 420  ALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFY 479
             L+R   KKS+ DL++ EE ED+ AD+ +VGSPFARAS+KS K E+S++F +KE+  RF+
Sbjct: 415  VLKRAATKKSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFF 474

Query: 480  IRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMY 539
            IRRMVK Q+FYW VL +VALNTLCVA+VHYNQP  L+  LY+AEF+FLGLF++EM +KMY
Sbjct: 475  IRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMY 534

Query: 540  GLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWAS 599
            GLG R YF SSFNCFD GVI+GS+FEV+WA IKPG+SFGISVLRALRLLRIFKVTKYW+S
Sbjct: 535  GLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSS 594

Query: 600  LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIM 659
            LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF + TP TNFDTFPAAI+
Sbjct: 595  LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAIL 654

Query: 660  TVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLAN 719
            TVFQILTGEDWN VMY GI+SQGGV  GM  S YFIVLTLFGNYTLLNVFLAIAVDNLAN
Sbjct: 655  TVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLAN 714

Query: 720  AQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRT 779
            AQELTKDE+E EEAANQKLALQKAKEVAEVSP+SAAN+SIA ++Q  N   A+SVWEQR 
Sbjct: 715  AQELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQQ--NSAKARSVWEQRA 772

Query: 780  SEMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQENRNNNTNKS 839
            S++R QNL AS EALY+EMDP+ER + A TRHLRPDMKTHLDRPLVV+   +        
Sbjct: 773  SQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLDRPLVVELGRDGARGPVGG 832

Query: 840  RAAEPTVDQRLGQQRAEDFLRKQARYHDRARDPSGSAGLDARRPWAGSQEAELSREGPYG 899
            +A     +   G     D  R+  R+ D+ + P+      A  P A S E     E P  
Sbjct: 833  KARPEAAEAPEGV----DPPRRHHRHRDKDKTPAAGDQDRAEAPKAESGEPGAREERPRP 888

Query: 900  RESDHHAREGSLEQPGFWEGEAERGKAGDPHRRHVHRQGGSRESRSGSPRTGADGEHRRH 959
              S  H++E +    G  E  +ERG+   P       +GG R  R GSP   A+ E RRH
Sbjct: 889  HRS--HSKEAA----GPPEARSERGRGPGP-------EGGRRHHRRGSPEEAAEREPRRH 935

Query: 960  RAHRR--PGEEGPEDKAERRARHREGSRPARGGEGEGEGPDGGERRRRHRHGAPATYEGD 1017
            RAHR   P +E    K ERRARHR G R    G  E E  +   RR R RH A   +E  
Sbjct: 936  RAHRHQDPSKECAGAKGERRARHRGGPR---AGPREAESGEEPARRHRARHKAQPAHEA- 991

Query: 1018 ARREDKERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAEDIDNMKNNKLATA 1077
                +KE   +   E +                            AE ++  K  +L   
Sbjct: 992  ---VEKETTEKEATEKE----------------------------AEIVEADKEKELRNH 1020

Query: 1078 ESAAPHGSLGHAGLPQSPAKMGNSTDPGPMLAIPA-----MATNPQNAASRRTPNNPGNP 1132
            +   PH  L  +G          +   GPM  +P+     +   P++A ++R     G  
Sbjct: 1021 QPREPHCDLETSG----------TVTVGPMHTLPSTCLQKVEEQPEDADNQRNVTRMG-- 1068

Query: 1133 SNPGPPKTPENSLIVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANP 1192
            S P  P                           +T V IP     PL    V  + N + 
Sbjct: 1069 SQPPDP---------------------------NTIVHIPVMLTGPLGEATVVPSGNVD- 1100

Query: 1193 DPLPKKEEEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILM 1252
              L  + E KKE E DD    GP+P+ PYSSMF LS TN LRR CHYI+ +RYFE+ IL+
Sbjct: 1101 --LESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILV 1158

Query: 1253 VIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDL 1312
            VIA+SSIALAAEDPV+ ++PRNN L+Y DY+FTGVFTFEMVIKMIDLGL+LH GAYFRDL
Sbjct: 1159 VIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDL 1218

Query: 1313 WNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVN 1372
            WNILDFIVVSGALVAFAF+G SKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVN
Sbjct: 1219 WNILDFIVVSGALVAFAFSG-SKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVN 1277

Query: 1373 SLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKAR 1432
            SLKNV NILIVYMLFMFIFAV+AVQLFKGKFF+CTDESKE E+DCRG+YL YEK EV+A+
Sbjct: 1278 SLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVEAQ 1337

Query: 1433 DREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYV 1492
             R+WKKY+FHYDNVLWALLTLFTVSTGEGWP VLKHSVDAT+E QGPSPGYRME+SIFYV
Sbjct: 1338 PRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYV 1397

Query: 1493 VYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNK 1552
            VYFVVFPFFFVNIFVALIIITFQEQGDK+M E SLEKNERACIDFAISAKPLTR+MPQN+
Sbjct: 1398 VYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNR 1457

Query: 1553 QSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLE 1612
            QSFQY+ W FVVSPPFEY IMAMIALNT+VLMMKFY A   YE  L+  NIVFTS+FS+E
Sbjct: 1458 QSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSME 1517

Query: 1613 CVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFG--NNFINLSFLRLFRAARLIK 1670
            CVLK++AFG+LNYFRDAWN+FDFVTVLGSITDILVTE    NNFINLSFLRLFRAARLIK
Sbjct: 1518 CVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIK 1577

Query: 1671 LLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDE 1730
            LLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNI +D        D+
Sbjct: 1578 LLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD--------DD 1629

Query: 1731 FQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFY 1790
              I  HNNFRTF QALMLLFRSATGEAWH IMLSCLS + CD+ +     ECG++FAYFY
Sbjct: 1630 TSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQAN--ATECGSDFAYFY 1687

Query: 1791 FVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYK 1850
            FVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDE++RVWAEYDPAACGRI Y 
Sbjct: 1688 FVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYN 1747

Query: 1851 DMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVA-DDNTVHFNSTLMALIRTALDIKI 1909
            DM+ +L+ +SPPLGLGKKCP RVA KRL+RM++P++ +D TVHF STLMALIRTAL+IK+
Sbjct: 1748 DMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKL 1807

Query: 1910 AKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQS 1969
            A  G  + Q DAELRKE+  +W NL QKTLDLLV PHK  ++TVGK+YAA+MI ++Y+Q+
Sbjct: 1808 APAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQN 1867

Query: 1970 KAKKLQAMREEQDRTPLMFQRMEP---------------PSPTQEGGPGQNALPSTQLDP 2014
            K       R++  + P    +M P               P+  +          ST L  
Sbjct: 1868 K-----TTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLRGARVFLRQKSSTSLSN 1922

Query: 2015 GGALMAHESGLKESPSWVTQRAQEMFQKTGTWSPEQGPPTDMP--NSQPNSQSVEMREMG 2072
            GGA+   ESG+KES SW TQR Q+   +      E+G  T++P   S   +  V+M+ + 
Sbjct: 1923 GGAIQNQESGIKESVSWGTQRTQDAPHEARP-PLERGHSTEIPVGRSGALAVDVQMQSIT 1981

Query: 2073 RDGYSDSEHYLPMEGQGRAASMPRLPAENQRRRGRPRGNNLSTISDTSPMKRSASVLG-- 2130
            R G  D E    +E QGRAASMPRL AE Q             ++D SPMKRS S L   
Sbjct: 1982 RRG-PDGEPQPGLESQGRAASMPRLAAETQ------------PVTDASPMKRSISTLAQR 2028

Query: 2131 PKARRLDDYSLERVPPEENQRHH-----QRRRDRSHRASERSLGRYTDVDTGLGTDLSMT 2185
            P+   L   + +R PP +   HH      RRRDR  R+ E+      D+D    + +   
Sbjct: 2029 PRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQRSLEKGPSLSADMDGAPSSAVGPG 2088

Query: 2186 TQSGDLPS-----KERDQERGRPKDRKHRQHHHHHHHHHHPPPPDKDRYAQERPDHGRAR 2240
               G+ P+     +ER QERGR ++R+            +      DR+    P   +  
Sbjct: 2089 LPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFY----SCDRFGGREPPKPKPS 2144

Query: 2241 ARDQRWSRSPSEGREHMAHRQ 2261
                    SP+ G+E   H Q
Sbjct: 2145 LSSH--PTSPTAGQEPGPHPQ 2163


>gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E
            subunit [Homo sapiens]
          Length = 2270

 Score = 2347 bits (6083), Expect = 0.0
 Identities = 1335/2297 (58%), Positives = 1567/2297 (68%), Gaps = 243/2297 (10%)

Query: 1    MARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQGGQ---PGAQRMYKQSMAQRAR 57
            MARFG+ + AR G G             G      +RQG      G    YKQ+ AQRAR
Sbjct: 1    MARFGEAVVARPGSGD------------GDSDQSRNRQGTPVPASGQAAAYKQTKAQRAR 48

Query: 58   TMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLAL 117
            TMALYNPIPVRQNC TVNRSLF+F EDN+VRKYAKK+ +WPPFEYMILATIIANCIVLAL
Sbjct: 49   TMALYNPIPVRQNCFTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLAL 108

Query: 118  EQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVV 177
            EQHLP+DDKTPMS RL+ TEPYFIGIFCFEAGIKI+ALGF FHKGSYLRNGWNVMDF+VV
Sbjct: 109  EQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVV 168

Query: 178  LTGILATVGTEF----DLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLL 233
            L+GILAT GT F    DLRTLRAVRVLRPLKLVSGIPSLQ+VLKSIMKAM+PLLQIGLLL
Sbjct: 169  LSGILATAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLL 228

Query: 234  FFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQG-ESPAPCGTEEPARTCPNGTKCQPYWE 292
            FFAIL+FAIIGLEFY GK H  CF   +  ++G + P PCG +     CP G +C+  W 
Sbjct: 229  FFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPCGVQG----CPAGYECKD-WI 283

Query: 293  GPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFML 352
            GPN+GITQFDNILFAVLTVFQCITMEGWT +LYN+NDA G TWNWLYFIPLIIIGSFF+L
Sbjct: 284  GPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVL 343

Query: 353  NLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGE 412
            NLVLGVLSGEFAKERERVENRRAF+KLRRQQQIERELNGY  WI KAEEV+LAE+  +  
Sbjct: 344  NLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAG 403

Query: 413  QRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKK 472
                    LRR TIK+S+T+ +  + +++   DI+SVG+P ARASIKSAK++  ++F  K
Sbjct: 404  TSAL--EVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHK 461

Query: 473  ERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMS 532
            ER +R  IR MVK+Q FYW VLSLVALNT CVAIVH+NQP+WL+  LYYAEF+FLGLF+ 
Sbjct: 462  ERLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLL 521

Query: 533  EMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFK 592
            EM +KMYG+G R YFHSSFNCFD GV +GSIFEV+WA+ +PGTSFGISVLRALRLLRIFK
Sbjct: 522  EMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFK 581

Query: 593  VTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFD 652
            +TKYWASLRNLVVSL++SMKSIISLLFLLFLFIVVFALLGMQLFGG+FNF++GTP  NFD
Sbjct: 582  ITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFD 641

Query: 653  TFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAI 712
            TFPAAIMTVFQILTGEDWNEVMY+GI+SQGGV  GM  +IYFIVLTLFGNYTLLNVFLAI
Sbjct: 642  TFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAI 701

Query: 713  AVDNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAK 772
            AVDNLANAQELTKDEQEEEEA NQK ALQKAKEV   SP+SA NM     E+ + ++   
Sbjct: 702  AVDNLANAQELTKDEQEEEEAFNQKHALQKAKEV---SPMSAPNMPSI--ERDRRRRHHM 756

Query: 773  SVWEQRTSEMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQENR 832
            S+WE R+S +R++          + M   E+  +   +H++   +  L+R     P  N 
Sbjct: 757  SMWEPRSSHLRERRRR-------HHMSVWEQRTSQLRKHMQMSSQEALNREEA--PTMNP 807

Query: 833  NNNTNKSRAAEPTVDQRLGQQRAEDFLRKQARYHDRARDPSGSA-GLDARRPWAGSQEAE 891
             N  N   +  P              L      + R R   G A GL   +     +E  
Sbjct: 808  LNPLNPLSSLNP--------------LNAHPSLYRRPRAIEGLALGLALEK----FEEER 849

Query: 892  LSREGPYGRESDHHAREGSLEQPGFWEGEAERGKAGDPHRRH---VHRQGGSRESRSGSP 948
            +SR G    +    +     ++     G+ E      P   +     ++ G  E+     
Sbjct: 850  ISRGGSLKGDGGDRSSALDNQRTPLSLGQREPPWLARPCHGNCDPTQQEAGGGEAVVTFE 909

Query: 949  RTGADGEHRRHRAHRRPGEEGPEDKAERRARHREGSRP---ARGGEGEGEGPDGGERRRR 1005
                  + +R   HRR   EG E  +  R+R     R    A   EGE +         R
Sbjct: 910  DRARHRQSQRRSRHRRVRTEGKESSSASRSRSASQERSLDEAMPTEGEKD------HELR 963

Query: 1006 HRHGAPATYEGDARREDKERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAED 1065
              HGA      + R +D  RR      ++GSG             +   L   D PL   
Sbjct: 964  GNHGAKEPTIQEERAQDL-RRTNSLMVSRGSG-------------LAGGLDEADTPLVLP 1009

Query: 1066 IDNMKNNKLATAESAAPHGSLGHAGLPQSPAKMGN-STDPGPMLAIPAMATNPQNAASRR 1124
               ++  K        P GS          A +GN   D G +++               
Sbjct: 1010 HPELEVGKHVVLTEQEPEGS-------SEQALLGNVQLDMGRVIS--------------- 1047

Query: 1125 TPNNPGNPSNPGPPKTPENSLIVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVV 1184
                            P+ S I  N     T S          TV IP    P ++ TVV
Sbjct: 1048 -------------QSEPDLSCITANTDKATTESTSV-------TVAIPDV-DPLVDSTVV 1086

Query: 1185 QVNKNANPDPLPKKEEEKKEEEED--------DRGEDGPKPMPPYSSMFILSTTNPLRRL 1236
             ++   + +  P KE E +E+EE+        ++ E G K M P+SSMFI STTNP+RR 
Sbjct: 1087 HISNKTDGEASPLKEAEIREDEEEVEKKKQKKEKRETG-KAMVPHSSMFIFSTTNPIRRA 1145

Query: 1237 CHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKM 1296
            CHYI+NLRYFEMCIL+VIA SSIALAAEDPV  N+ RN VLRYFDYVFTGVFTFEMVIKM
Sbjct: 1146 CHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKM 1205

Query: 1297 IDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFT---GNSKGKDINTIKSLRVLRVLRP 1353
            ID GL+L  G+YFRDLWNILDF+VV GALVAFA     G +KG+DI TIKSLRVLRVLRP
Sbjct: 1206 IDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRP 1265

Query: 1354 LKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEF 1413
            LKTIKRLPKLKAVFDCVV SLKNVFNILIVY LFMFIFAV+AVQLFKGKFF+CTD SK+ 
Sbjct: 1266 LKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDT 1325

Query: 1414 EKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDAT 1473
            EK+C G Y+ +EKN+++ + REWK++EFHYDN++WALLTLFTVSTGEGWPQVL+HSVD T
Sbjct: 1326 EKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVT 1385

Query: 1474 FENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERA 1533
             E++GPS   RMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEE SLEKNERA
Sbjct: 1386 EEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERA 1445

Query: 1534 CIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVA 1593
            CIDFAISAKPLTR+MPQN+ +FQYR+W FVVSP FEYTIMAMIALNT+VLMMK+Y A   
Sbjct: 1446 CIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCT 1505

Query: 1594 YENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTE---F 1650
            YE AL+  NI FT +FSLECVLKV+AFG LNYFRD WNIFDF+TV+GSIT+I++T+    
Sbjct: 1506 YELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLV 1565

Query: 1651 GNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1710
              +  N+SFL+LFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG
Sbjct: 1566 NTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1625

Query: 1711 MQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKP 1770
            MQVFGNI +D        +E  I  HNNFR+FF +LMLLFRSATGEAW  IMLSCL  K 
Sbjct: 1626 MQVFGNIKLD--------EESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKG 1677

Query: 1771 CDKN----SGILTRE-CGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILG 1825
            C+ +    SG    E CG + AY YFVSFIF CSFLMLNLFVAVIMDNFEYLTRDSSILG
Sbjct: 1678 CEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILG 1737

Query: 1826 PHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPV 1885
            PHHLDE+VRVWAEYD AACGRIHY +MY +L ++SPPLGLGK+CP +VA KRL+ M++PV
Sbjct: 1738 PHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPV 1797

Query: 1886 ADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTP 1945
            A+D TVHF STLMALIRTALDIKIAKGGAD+QQ+D+EL+KE +AIWP+LSQK LDLLV  
Sbjct: 1798 AEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPM 1857

Query: 1946 HKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREEQDRTPLMFQRMEPPSPTQEGGPGQN 2005
             K++DLTVGKIYAAMMIM+YY+QSK KK +   EEQ   P MFQRMEP S  QE      
Sbjct: 1858 PKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQLEEQKNAP-MFQRMEPSSLPQEIIANAK 1916

Query: 2006 ALPSTQLDPGGALMAHESGLKESPSWVTQRAQEMFQKTGTWSPEQGPPTDMPNSQPNSQS 2065
            ALP  Q DP   L    SG    PS      Q++FQ                        
Sbjct: 1917 ALPYLQQDPVSGL----SGRSGYPSMSPLSPQDIFQ------------------------ 1948

Query: 2066 VEMREMGRDGYSDSEHYLPMEGQGRAASMPRLPAENQRRRGRPRGNNLSTISDTSPMKRS 2125
            +   +   DG          + Q R + +   P+  +R        + STI D    KRS
Sbjct: 1949 LACMDPADDG----------QFQERQSLVVTDPSSMRR--------SFSTIRD----KRS 1986

Query: 2126 ASVLGPKARRLDDYSLERVPPEENQRHHQRRRDRSHRASERSLGRYTDVDTGLGTDLSMT 2185
             S        L+++S+ER     +  +  + R RS+ +S R      + D+G  +D   T
Sbjct: 1987 NS------SWLEEFSMER-----SSENTYKSRRRSYHSSLRLSAHRLNSDSGHKSD---T 2032

Query: 2186 TQSGDLPSKERDQERGRPKDRKHRQHHHHHHHHHHPPPPDKDR-YAQERPDHGRARARDQ 2244
             +SG        +ERGR K+RKH               PD  R  ++ER       + ++
Sbjct: 2033 HRSG-------GRERGRSKERKHLL------------SPDVSRCNSEERGTQADWESPER 2073

Query: 2245 RWSRSPSEGREHMAHRQ 2261
            R SRSPSEGR    +RQ
Sbjct: 2074 RQSRSPSEGRSQTPNRQ 2090


>gi|192807298 calcium channel, voltage-dependent, L type, alpha 1D
            subunit isoform c [Homo sapiens]
          Length = 2137

 Score =  781 bits (2016), Expect = 0.0
 Identities = 398/810 (49%), Positives = 551/810 (68%), Gaps = 41/810 (5%)

Query: 1192 PDPLPKKEEEKKEEEEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLC 1237
            P  +P  EEE++EEE++     GP+P              +P  S+ FILS TNP+R  C
Sbjct: 820  PCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGC 879

Query: 1238 HYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMI 1297
            H ++N   F   IL+ I +SS ALAAEDP++ ++ RN +L YFDY FT +FT E+++KM 
Sbjct: 880  HKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMT 939

Query: 1298 DLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTI 1357
              G  LH+GA+ R+ +N+LD +VV  +LV+F    ++    I+ +K LRVLRVLRPL+ I
Sbjct: 940  TFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSA----ISVVKILRVLRVLRPLRAI 995

Query: 1358 KRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC 1417
             R   LK V  CV  +++ + NI+IV  L  F+FA + VQLFKGKF+ CTDE+K   ++C
Sbjct: 996  NRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEEC 1055

Query: 1418 RGKYLLYEKNEVKA---RDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
            RG ++LY+  +V +   R+R W+  +F++DNVL A++ LFTVST EGWP +L  ++D+  
Sbjct: 1056 RGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNG 1115

Query: 1475 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERAC 1534
            EN GP   +R+E+SIF+++Y ++  FF +NIFV  +I+TFQEQG+K  +   L+KN+R C
Sbjct: 1116 ENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQC 1175

Query: 1535 IDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAY 1594
            +++A+ A+PL R++P+N   +QY+ W  V S PFEY +  +I LNT+ L M+ Y  S  +
Sbjct: 1176 VEYALKARPLRRYIPKNP--YQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMF 1233

Query: 1595 ENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGN-- 1652
             +A+ + N+VFT +F++E VLKV+AF    YF DAWN FD + V+GSI D+ ++E  N  
Sbjct: 1234 NDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSE 1293

Query: 1653 --NFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1710
              N I+++F RLFR  RL+KLL +G  IR LLWTF++SF+ALPYV LLIAMLFFIYA+IG
Sbjct: 1294 ESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIG 1353

Query: 1711 MQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKP 1770
            MQ+FG + +         D  QI  +NNF+TF QA++LLFR ATGEAW  IML+CL GK 
Sbjct: 1354 MQMFGKVAM--------RDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL 1405

Query: 1771 CDKNSGILTRE---CGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPH 1827
            CD  S     E   CG+ FA  YF+SF  LC+FL++NLFVAVIMDNF+YLTRD SILGPH
Sbjct: 1406 CDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH 1465

Query: 1828 HLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVAD 1887
            HLDE+ R+W+EYDP A GRI + D+ +LLR I PPLG GK CPHRVACKRL+ M++P+  
Sbjct: 1466 HLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS 1525

Query: 1888 DNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHK 1947
            D TV FN+TL AL+RTAL IK      + +Q + ELR  +  IW   S K LD +V P  
Sbjct: 1526 DGTVMFNATLFALVRTALKIKTE---GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAG 1582

Query: 1948 STDLTVGKIYAAMMIMEYYRQSKAKKLQAM 1977
              ++TVGK YA  +I +Y+R+ K +K Q +
Sbjct: 1583 DDEVTVGKFYATFLIQDYFRKFKKRKEQGL 1612



 Score =  654 bits (1686), Expect = 0.0
 Identities = 354/724 (48%), Positives = 470/724 (64%), Gaps = 39/724 (5%)

Query: 76  RSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDD 135
           R+LF  S +N +R+    I EW PF+  IL  I ANC+ LA+    P+DD    +  L+ 
Sbjct: 104 RALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEK 163

Query: 136 TEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------- 188
            E  F+ IF  E  +KIIA G   H  +Y+RNGWN++DFV+V+ G+ + +  +       
Sbjct: 164 VEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEG 223

Query: 189 ----------FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAIL 238
                     FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAM+PLL I LL+ F I+
Sbjct: 224 GNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 283

Query: 239 IFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCP-NGTKCQPYWEGPNNG 297
           I+AIIGLE ++GK H TCF   +D +  E PAPC      R C  NGT+C+  W GPN G
Sbjct: 284 IYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGG 343

Query: 298 ITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLG 357
           IT FDN  FA+LTVFQCITMEGWTD+LY  NDA G    W+YF+ L+I GSFF+LNLVLG
Sbjct: 344 ITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLG 403

Query: 358 VLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPF 417
           VLSGEF+KERE+ + R  F KLR +QQ+E +L GY++WI++AE++    +E  GE+    
Sbjct: 404 VLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEE---- 459

Query: 418 DGALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMR 477
               R T++  S+T+ +N E    +  +    GS     +I  +KL  S  + +  R  R
Sbjct: 460 --GKRNTSMPTSETESVNTENVSGEGENRGCCGS--LCQAISKSKL--SRRWRRWNRFNR 513

Query: 478 FYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIK 537
              R  VK+  FYW V+ LV LNTL ++  HYNQP+WL+     A  + L LF  EM +K
Sbjct: 514 RRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVK 573

Query: 538 MYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYW 597
           MY LG + YF S FN FDC V+ G I E I   ++  +  GISV R +RLLRIFKVT++W
Sbjct: 574 MYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHW 633

Query: 598 ASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDE-GTPPTNFDTFPA 656
            SL NLV SLLNSMKSI SLL LLFLFI++F+LLGMQLFGG+FNFDE  T  + FD FP 
Sbjct: 634 TSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQ 693

Query: 657 AIMTVFQILTGEDWNEVMYDGIKSQGG-VQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVD 715
           A++TVFQILTGEDWN VMYDGI + GG    GM+  IYFI+L + GNY LLNVFLAIAVD
Sbjct: 694 ALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVD 753

Query: 716 NLANAQEL-TKDEQEEEEAANQKLALQKAKE-----VAEVSPLSAANMSIAV---KEQQK 766
           NLA+A+ L T  ++E EE   +K+A +++ E       EV+ ++ ++  + +   +E+ +
Sbjct: 754 NLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDE 813

Query: 767 NQKP 770
           ++ P
Sbjct: 814 DKDP 817



 Score =  217 bits (552), Expect = 1e-55
 Identities = 180/719 (25%), Positives = 329/719 (45%), Gaps = 121/719 (16%)

Query: 1185 QVNKNANPDPLPKKEEEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLR 1244
            Q    + P P+    + K+++    + +       P  ++F LS  NP+RR C  I+  +
Sbjct: 67   QTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWK 126

Query: 1245 YFEMCILMVIAMSSIALAAEDPVQPNAPR--NNVLRYFDYVFTGVFTFEMVIKMIDLGLV 1302
             F++ IL+ I  + +ALA   P   +     N+ L   +Y F  +FT E  +K+I  GL+
Sbjct: 127  PFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLL 186

Query: 1303 LHQGAYFRDLWNILDFIVVSGALVAFAF-------------TGNSKGKDINTIKSLRVLR 1349
            LH  AY R+ WN+LDF++V   L +                +G S G D   +K+LR  R
Sbjct: 187  LHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFD---VKALRAFR 243

Query: 1350 VLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGK-----FF 1404
            VLRPL+ +  +P L+ V + ++ ++  + +I ++ +  + I+A++ ++LF GK     FF
Sbjct: 244  VLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFF 303

Query: 1405 HCTD-ESKEFEKDC----RGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTG 1459
              +D  ++E    C     G+       E ++          ++DN  +A+LT+F   T 
Sbjct: 304  ADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITM 363

Query: 1460 EGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFV-NIFVALIIITFQEQ- 1517
            EGW  VL    DA             E+   Y V  V+F  FFV N+ + ++   F ++ 
Sbjct: 364  EGWTDVLYWMNDA----------MGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKER 413

Query: 1518 ------GD--KMMEEYSLEKNERACIDFAISAK--------------------------- 1542
                  GD  K+ E+  LE++ +  +D+   A+                           
Sbjct: 414  EKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETES 473

Query: 1543 -----------------PLTRHMPQNKQSFQYRMWQ---------FVVSPPFEYTIMAMI 1576
                              L + + ++K S ++R W           V S  F + ++ ++
Sbjct: 474  VNTENVSGEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLV 533

Query: 1577 ALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFV 1636
             LNT+ +  + Y           + N V  +LF+ E ++K+ + G+  YF   +N FD  
Sbjct: 534  FLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCF 593

Query: 1637 TVLGSITDILVTEFG-NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1695
             V G IT+ ++ E    + + +S  R  R  R+ K+ R   ++  L+ + + S K++  +
Sbjct: 594  VVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASL 653

Query: 1696 CLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATG 1755
             LL+ +   I++++GMQ+FG           + DE Q T+ + F  F QAL+ +F+  TG
Sbjct: 654  LLLLFLFIIIFSLLGMQLFGG--------KFNFDETQ-TKRSTFDNFPQALLTVFQILTG 704

Query: 1756 EAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
            E W+ +M   +       +SG++           YF+  +F+C ++++LN+F+A+ +DN
Sbjct: 705  EDWNAVMYDGIMAYGGPSSSGMI--------VCIYFI-ILFICGNYILLNVFLAIAVDN 754



 Score =  191 bits (484), Expect = 9e-48
 Identities = 167/691 (24%), Positives = 296/691 (42%), Gaps = 138/691 (19%)

Query: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
            + F+ S+ N +R    K+     F  +IL  I+ +   LA E   P    +  +  L   
Sbjct: 865  AFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAED--PIRSHSFRNTILGYF 922

Query: 137  EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
            +  F  IF  E  +K+   G   HKG++ RN +N++D +VV    L + G +      ++
Sbjct: 923  DYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVS-LVSFGIQSSAISVVK 981

Query: 193  TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      +FA IG++ + GKF
Sbjct: 982  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1041

Query: 253  HTTCFEEGTDDIQ-----------GESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQF 301
            +  C +E   + +           G+  +P   E               W+   N    F
Sbjct: 1042 YR-CTDEAKSNPEECRGLFILYKDGDVDSPVVRER-------------IWQ---NSDFNF 1084

Query: 302  DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLY---------FIPLIIIGSFFML 352
            DN+L A++ +F   T EGW  LLY + D++G     +Y         FI  III +FFM+
Sbjct: 1085 DNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMM 1144

Query: 353  NLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGE 412
            N+ +G                  F+ +  Q+Q E+E                   E D  
Sbjct: 1145 NIFVG------------------FVIVTFQEQGEKEYKNC---------------ELDKN 1171

Query: 413  QRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKK 472
            QR   + AL+   +++                                       +  K 
Sbjct: 1172 QRQCVEYALKARPLRR---------------------------------------YIPKN 1192

Query: 473  ERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMS 532
              + +F+   +V +  F + +  L+ LNTLC+A+ HY Q +  +D +     +F G+F  
Sbjct: 1193 PYQYKFWY--VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTV 1250

Query: 533  EMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVI---KPGTSFGISVLRALRLLR 589
            EM +K+     + YF  ++N FD  ++IGSI +V  +     +      I+  R  R++R
Sbjct: 1251 EMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMR 1310

Query: 590  IFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEG--TP 647
            + K+      +R L+ + + S +++  +  L+ +   ++A++GMQ+FG     D      
Sbjct: 1311 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINR 1370

Query: 648  PTNFDTFPAAIMTVFQILTGEDWNEVMY------------DGIKSQGGVQGGMVFSIYFI 695
              NF TFP A++ +F+  TGE W E+M             D    +    G     +YFI
Sbjct: 1371 NNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFI 1430

Query: 696  VLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
               +   + ++N+F+A+ +DN      LT+D
Sbjct: 1431 SFYMLCAFLIINLFVAVIMDNF---DYLTRD 1458



 Score =  139 bits (349), Expect = 4e-32
 Identities = 177/787 (22%), Positives = 321/787 (40%), Gaps = 169/787 (21%)

Query: 24   VVGSGGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSE 83
            V G G  RG  GS        Q + K  +++R R    +N    R+ C            
Sbjct: 479  VSGEGENRGCCGSL------CQAISKSKLSRRWRRWNRFN----RRRC------------ 516

Query: 84   DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 143
                R   K +T    F ++++  +  N + ++ E +   D  T +    D      + +
Sbjct: 517  ----RAAVKSVT----FYWLVIVLVFLNTLTISSEHYNQPDWLTQIQ---DIANKVLLAL 565

Query: 144  FCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT------LRAV 197
            F  E  +K+ +LG      +Y  + +N  D  VV  GI  T+  E ++ +       R V
Sbjct: 566  FTCEMLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCV 621

Query: 198  RVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF 257
            R+LR  K+     SL  ++ S++ +M  +  + LLLF  I+IF+++G++ + GKF+   F
Sbjct: 622  RLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFN---F 678

Query: 258  EEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITM 317
            +E              T+    T                    FDN   A+LTVFQ +T 
Sbjct: 679  DE--------------TQTKRST--------------------FDNFPQALLTVFQILTG 704

Query: 318  EGWTDLLYNSNDASGNTWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEFAK------- 365
            E W  ++Y+   A G   +      +YFI L I G++ +LN+ L +     A        
Sbjct: 705  EDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTA 764

Query: 366  ERERVENRRAFLKLRRQQQIERELNGYME--WISKAEEVILAED-ETDGEQRHPFDGALR 422
            ++E  E +    K+ R++ +E + N   E   I+ ++  +  +D   + E + P+     
Sbjct: 765  QKEEAEEKER-KKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPC-- 821

Query: 423  RTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKL--------ENSTFFH-KKE 473
                     D+   EE E++  D   V +      I    +        E S FF   K 
Sbjct: 822  ---------DVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKT 872

Query: 474  RRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH-YNQPEWLSDFLYYAEFIFLGLFMS 532
              +R    +++    F   +L  + L++  +A         + +  L Y ++ F  +F  
Sbjct: 873  NPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTV 932

Query: 533  EMFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLL 588
            E+ +KM   G       +  + FN  D  V+  S+  V + +     S  + +LR LR+L
Sbjct: 933  EILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSL--VSFGIQSSAISV-VKILRVLRVL 989

Query: 589  RIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF-------- 640
            R  +       L+++V  +  ++++I +++ +  L   +FA +G+QLF G+F        
Sbjct: 990  RPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAK 1049

Query: 641  --------------NFDEGTPPT----------NFDTFPAAIMTVFQILTGEDWNEVMYD 676
                          + D  +P            NFD   +A+M +F + T E W  ++Y 
Sbjct: 1050 SNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYK 1109

Query: 677  GIKSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEE 731
             I S G   G +       SI+FI+  +   + ++N+F+   +        +T  EQ E+
Sbjct: 1110 AIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVI--------VTFQEQGEK 1161

Query: 732  EAANQKL 738
            E  N +L
Sbjct: 1162 EYKNCEL 1168



 Score = 80.9 bits (198), Expect = 1e-14
 Identities = 74/296 (25%), Positives = 131/296 (44%), Gaps = 61/296 (20%)

Query: 1567 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1623
            PF+  I+  I  N + L +        S +  + L      F  +F++E  LK++A+G+L
Sbjct: 127  PFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLL 186

Query: 1624 ----NYFRDAWNIFDFVTVLGSITDILV------TEFGNNF------INLSFLRLFRAAR 1667
                 Y R+ WN+ DFV V+  +  +++      TE GN+        ++  LR FR  R
Sbjct: 187  LHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLR 246

Query: 1668 LIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-GNIGIDVEDEDS 1726
             ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F G +       DS
Sbjct: 247  PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADS 306

Query: 1727 D----EDEF---------QITEHN---------------NFRTFFQALMLLFRSATGEAW 1758
            D    ED           Q T +                NF  F  A++ +F+  T E W
Sbjct: 307  DIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGW 366

Query: 1759 HNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
             +++               +    G E  + YFVS +   SF +LNL + V+   F
Sbjct: 367  TDVLYW-------------MNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 409


>gi|193788548 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 20 [Homo sapiens]
          Length = 2127

 Score =  779 bits (2011), Expect = 0.0
 Identities = 407/858 (47%), Positives = 564/858 (65%), Gaps = 45/858 (5%)

Query: 1146 IVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEE 1205
            +V  P+  ++   K   K      + PPA    +N   +Q N+N +  P P  E   +E+
Sbjct: 790  LVEKPAVGESKEEKIELKSITADGESPPATK--INMDDLQPNENEDKSPYPNPETTGEED 847

Query: 1206 EEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLCHYILNLRYFEMCIL 1251
            EE+     GP+P              MP  S+ FI S+ N  R  CH I+N   F   IL
Sbjct: 848  EEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLIL 907

Query: 1252 MVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRD 1311
              I +SSI+LAAEDPVQ  + RN++L   DYVFT +FT E+++KM   G  LH+G++ R+
Sbjct: 908  FFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRN 967

Query: 1312 LWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVV 1371
             +NILD +VVS +L++F    ++    IN +K LRVLRVLRPL+ I R   LK V  CV 
Sbjct: 968  YFNILDLLVVSVSLISFGIQSSA----INVVKILRVLRVLRPLRAINRAKGLKHVVQCVF 1023

Query: 1372 NSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK- 1430
             +++ + NI+IV  L  F+FA + VQLFKGK + C+D SK+ E +C+G Y+ Y+  EV  
Sbjct: 1024 VAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDH 1083

Query: 1431 --ARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMS 1488
               + R W+  +F +DNVL A++ LFTVST EGWP++L  S+D+  E++GP   YR+E+S
Sbjct: 1084 PIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEIS 1143

Query: 1489 IFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHM 1548
            IF+++Y ++  FF +NIFV  +I+TFQEQG++  +   L+KN+R C+++A+ A+PL R++
Sbjct: 1144 IFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYI 1203

Query: 1549 PQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSL 1608
            P+N+   QY++W  V S  FEY +  +I LNTI L M+ YG S  ++ A+ + N++FT L
Sbjct: 1204 PKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGL 1261

Query: 1609 FSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGN----NFINLSFLRLFR 1664
            F++E +LK++AF   +YF DAWN FD + V+GSI DI +TE  N    + I+++F RLFR
Sbjct: 1262 FTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFR 1321

Query: 1665 AARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDE 1724
              RL+KLL +G  IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQVFG I ++    
Sbjct: 1322 VMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALN---- 1377

Query: 1725 DSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPC-----DKNSGILT 1779
                D  +I  +NNF+TF QA++LLFR ATGEAW +IML+C+ GK C       NS    
Sbjct: 1378 ----DTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGE 1433

Query: 1780 RECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEY 1839
              CG+ FA FYF+SF  LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDE+ R+WAEY
Sbjct: 1434 TPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEY 1493

Query: 1840 DPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMA 1899
            DP A GRI + D+ +LLR I PPLG GK CPHRVACKRL+ M++P+  D TV FN+TL A
Sbjct: 1494 DPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFA 1553

Query: 1900 LIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAA 1959
            L+RTAL IK      + +Q + ELR  +  IW   S K LD +V P    ++TVGK YA 
Sbjct: 1554 LVRTALRIKTE---GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYAT 1610

Query: 1960 MMIMEYYRQSKAKKLQAM 1977
             +I EY+R+ K +K Q +
Sbjct: 1611 FLIQEYFRKFKKRKEQGL 1628



 Score =  671 bits (1730), Expect = 0.0
 Identities = 383/827 (46%), Positives = 507/827 (61%), Gaps = 64/827 (7%)

Query: 2   ARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQG-----------GQPGAQRMYKQ 50
           + +G   PA +    + AAAG+        GA  S Q            G  G   +   
Sbjct: 18  SNYGSPRPA-HANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTV 76

Query: 51  SMAQRARTMALYNPIPVRQNCLTVNR---SLFLFSEDNVVRKYAKKITEWPPFEYMILAT 107
           S  QR R    Y   P +Q   T  R   +L   +  N +R+    I EW PFE +IL T
Sbjct: 77  SSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLT 133

Query: 108 IIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRN 167
           I ANC+ LA+    P+DD    +  L+  E  F+ IF  EA +K+IA G  FH  +YLRN
Sbjct: 134 IFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRN 193

Query: 168 GWNVMDFVVVLTGILATV----------------GTEFDLRTLRAVRVLRPLKLVSGIPS 211
           GWN++DF++V+ G+ + +                G  FD++ LRA RVLRPL+LVSG+PS
Sbjct: 194 GWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPS 253

Query: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF-EEGTDDIQGES-P 269
           LQVVL SI+KAM+PLL I LL+ F I+I+AIIGLE +MGK H TC+ +EG  D+  E  P
Sbjct: 254 LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 270 APCGTEEP-ARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSN 328
           +PC  E    R C NGT C+P W+GP +GIT FDN  FA+LTVFQCITMEGWTD+LY  N
Sbjct: 314 SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 329 DASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 388
           DA G  W W+YF+ LIIIGSFF+LNLVLGVLSGEF+KERE+ + R  F KLR +QQ+E +
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433

Query: 389 LNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIAS 448
           L GY++WI++AE++    ++   ++  P     R  ++  S+T+ +N E       +  +
Sbjct: 434 LKGYLDWITQAEDIDPENEDEGMDEEKP-----RNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 449 VGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH 508
            G   AR + + +K + S ++ +  R  R   R  VK+  FYW V+ LV LNTL +A  H
Sbjct: 489 CG---ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEH 545

Query: 509 YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIW 568
           YNQP WL++    A    L LF +EM +KMY LG + YF S FN FDC V+ G I E I 
Sbjct: 546 YNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETIL 605

Query: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
              K  +  GISVLR +RLLRIFK+T+YW SL NLV SLLNS++SI SLL LLFLFI++F
Sbjct: 606 VETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIF 665

Query: 629 ALLGMQLFGGQFNFDE-GTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQ-G 686
           +LLGMQLFGG+FNFDE  T  + FD FP +++TVFQILTGEDWN VMYDGI + GG    
Sbjct: 666 SLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 687 GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEV 746
           GM+  IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EEEE   +K         
Sbjct: 726 GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERK--------- 776

Query: 747 AEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREA 793
                   A  +   K+Q+  +KPA  V E +  ++  +++ A  E+
Sbjct: 777 ------KLARTASPEKKQELVEKPA--VGESKEEKIELKSITADGES 815



 Score =  202 bits (513), Expect = 4e-51
 Identities = 176/705 (24%), Positives = 317/705 (44%), Gaps = 120/705 (17%)

Query: 1200 EEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSI 1259
            + K+++    + +       P  ++  L+  NP+RR C  I+  + FE+ IL+ I  + +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1260 ALAAEDPV---QPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNIL 1316
            ALA   P      NA  +N+ R  +Y+F  +FT E  +K+I  GL+ H  AY R+ WN+L
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV-EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198

Query: 1317 DFIVVSGALVAFAFTGNSKGKDINT---------IKSLRVLRVLRPLKTIKRLPKLKAVF 1367
            DFI+V   L +      +K    N          +K+LR  RVLRPL+ +  +P L+ V 
Sbjct: 199  DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258

Query: 1368 DCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC---------- 1417
            + ++ ++  + +I ++ +  + I+A++ ++LF GK  H T  ++E   D           
Sbjct: 259  NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK-MHKTCYNQEGIADVPAEDDPSPCA 317

Query: 1418 --RGKYLLYEKNEVKARDREWKKYEF-HYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
               G     +   V     +  K+   ++DN  +A+LT+F   T EGW  VL    DA  
Sbjct: 318  LETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAV- 376

Query: 1475 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KMMEEY 1525
                     R    I++V   ++  FF +N+ + ++   F ++       GD  K+ E+ 
Sbjct: 377  --------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428

Query: 1526 SLEKNERACIDFAISA---------------KPLTRHMP--------------------- 1549
             LE++ +  +D+   A               KP    MP                     
Sbjct: 429  QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 1550 ----------QNKQSFQYRMWQ---------FVVSPPFEYTIMAMIALNTIVLMMKFYGA 1590
                      ++K S  +R W           V S  F + ++ ++ LNT+ +  + Y  
Sbjct: 489  CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548

Query: 1591 SVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITD-ILVTE 1649
                       N    +LF+ E +LK+ + G+  YF   +N FD   V G I + ILV  
Sbjct: 549  PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 1650 FGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAII 1709
               + + +S LR  R  R+ K+ R   ++  L+ + + S +++  + LL+ +   I++++
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 1710 GMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGK 1769
            GMQ+FG           + DE Q T  + F  F Q+L+ +F+  TGE W+++M   +   
Sbjct: 669  GMQLFGG--------KFNFDEMQ-TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAY 719

Query: 1770 PCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
                  G+L           YF+  +F+C ++++LN+F+A+ +DN
Sbjct: 720  GGPSFPGML--------VCIYFI-ILFICGNYILLNVFLAIAVDN 755



 Score =  143 bits (360), Expect = 2e-33
 Identities = 179/785 (22%), Positives = 325/785 (41%), Gaps = 161/785 (20%)

Query: 33   AGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAK 92
            AGG  +G   GA+  ++ S ++ +R    +N    R+ C    +S       NV      
Sbjct: 480  AGGDIEGENCGARLAHRISKSKFSRYWRRWNRF-CRRKCRAAVKS-------NV------ 525

Query: 93   KITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKI 152
                   F ++++  +  N + +A E +   +    ++E  D      + +F  E  +K+
Sbjct: 526  -------FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKM 575

Query: 153  IALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------FDLRTLRAVRVLRPLKLV 206
             +LG      +Y  + +N  D  VV  GIL T+  E        +  LR VR+LR  K+ 
Sbjct: 576  YSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKIT 631

Query: 207  SGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQG 266
                SL  ++ S++ ++  +  + LLLF  I+IF+++G++ + GKF+        D++Q 
Sbjct: 632  RYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF-------DEMQT 684

Query: 267  ESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYN 326
                                            + FDN   ++LTVFQ +T E W  ++Y+
Sbjct: 685  RR------------------------------STFDNFPQSLLTVFQILTGEDWNSVMYD 714

Query: 327  SNDASGNT-----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERE 368
               A G          +YFI L I G++ +LN+ L +     A             +E+E
Sbjct: 715  GIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKE 774

Query: 369  RVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIK- 427
            R +  R     ++Q+ +E+   G     SK E++ L     DGE   P    +    ++ 
Sbjct: 775  RKKLARTASPEKKQELVEKPAVGE----SKEEKIELKSITADGES--PPATKINMDDLQP 828

Query: 428  ---KSKTDLLNPEEA--EDQLADIASVGS---PFARASIKSAKL---ENSTFF-HKKERR 475
               + K+   NPE    ED+      VG    P +   +K   +   E S FF      R
Sbjct: 829  NENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNR 888

Query: 476  MRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ-PEWLSDFLYYAEFIFLGLFMSEM 534
             R    R+V    F   +L  + L+++ +A     Q   + +  L  A+++F  +F  E+
Sbjct: 889  FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEI 948

Query: 535  FIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRI 590
             +KM   G       +  + FN  D  V+  S+       I+      + +LR LR+LR 
Sbjct: 949  ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRP 1005

Query: 591  FKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQ-FNFDEGTPPT 649
             +       L+++V  +  ++++I +++ +  L   +FA +G+QLF G+ +   + +  T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 650  -------------------------------NFDTFPAAIMTVFQILTGEDWNEVMYDGI 678
                                           +FD   AA+M +F + T E W E++Y  I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 679  KSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEA 733
             S    +G +       SI+FI+  +   + ++N+F+   +        +T  EQ E+E 
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEY 1177

Query: 734  ANQKL 738
             N +L
Sbjct: 1178 KNCEL 1182



 Score =  116 bits (291), Expect = 2e-25
 Identities = 96/331 (29%), Positives = 163/331 (49%), Gaps = 33/331 (9%)

Query: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
            + F+FS +N  R    +I     F  +IL  I+ + I LA E   P    +  +  L + 
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILGNA 936

Query: 137  EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV   ++ + G +      ++
Sbjct: 937  DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLI-SFGIQSSAINVVK 995

Query: 193  TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      +FA IG++ + GK 
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 253  HTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----WEGPNNGITQFDNILFA 307
            +T        D   ++ A C  +    T  +G    P      WE   N    FDN+L A
Sbjct: 1056 YT------CSDSSKQTEAEC--KGNYITYKDGEVDHPIIQPRSWE---NSKFDFDNVLAA 1104

Query: 308  VLTVFQCITMEGWTDLLYNSNDA----SGNTWNW-----LYFIPLIIIGSFFMLNLVLGV 358
            ++ +F   T EGW +LLY S D+     G  +N+     ++FI  III +FFM+N+ +G 
Sbjct: 1105 MMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGF 1164

Query: 359  LSGEFAKERERVENRRAFLKLRRQQQIEREL 389
            +   F ++ E+ E +   L   ++Q +E  L
Sbjct: 1165 VIVTFQEQGEQ-EYKNCELDKNQRQCVEYAL 1194



 Score =  114 bits (286), Expect = 8e-25
 Identities = 73/283 (25%), Positives = 138/283 (48%), Gaps = 31/283 (10%)

Query: 472  KERRMRFYIRR---------MVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 522
            K R +R YI +         +V +  F + +  L+ LNT+C+A+ HY Q       +   
Sbjct: 1195 KARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNIL 1254

Query: 523  EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVI---KPGTSFGI 579
              +F GLF  EM +K+     + YF  ++N FD  +++GSI ++    +   +  +   I
Sbjct: 1255 NMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISI 1314

Query: 580  SVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG-- 637
            +  R  R++R+ K+      +R L+ + + S +++  +  L+ +   ++A++GMQ+FG  
Sbjct: 1315 TFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKI 1374

Query: 638  GQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMY-------------DGIKSQGGV 684
               +  E     NF TFP A++ +F+  TGE W ++M                  ++G  
Sbjct: 1375 ALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGET 1434

Query: 685  QGGMVFSI-YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
              G  F++ YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1435 PCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1474



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 79/311 (25%), Positives = 143/311 (45%), Gaps = 41/311 (13%)

Query: 1234 RRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMV 1293
            RR C   +    F   ++ ++ ++++ +A+E   QPN     V    +     +FT EM+
Sbjct: 514  RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW-LTEVQDTANKALLALFTAEML 572

Query: 1294 IKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRP 1353
            +KM  LGL     AYF  L+N  D  VV G ++            +  I  LR +R+LR 
Sbjct: 573  LKMYSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLG-ISVLRCVRLLRI 627

Query: 1354 LKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEF 1413
             K  +    L  +   ++NS++++ ++L++  LF+ IF+++ +QLF GKF          
Sbjct: 628  FKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF---------- 677

Query: 1414 EKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDAT 1473
                         +E++ R          +DN   +LLT+F + TGE W  V+    D  
Sbjct: 678  -----------NFDEMQTRRST-------FDNFPQSLLTVFQILTGEDWNSVM---YDGI 716

Query: 1474 FENQGPS-PGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNER 1532
                GPS PG  M + I++++ F+   +  +N+F+A+ +    +  + +      E+ E+
Sbjct: 717  MAYGGPSFPG--MLVCIYFIILFICGNYILLNVFLAIAVDNLAD-AESLTSAQKEEEEEK 773

Query: 1533 ACIDFAISAKP 1543
                 A +A P
Sbjct: 774  ERKKLARTASP 784



 Score = 82.0 bits (201), Expect = 6e-15
 Identities = 73/297 (24%), Positives = 130/297 (43%), Gaps = 62/297 (20%)

Query: 1567 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1623
            PFE  I+  I  N + L +        S A  + L     +F  +F++E  LKV+A+G+L
Sbjct: 125  PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1624 ----NYFRDAWNIFDFVTVLGSITDILVTEF----GNNFI-------NLSFLRLFRAARL 1668
                 Y R+ WN+ DF+ V+  +   ++ +     G N +       ++  LR FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1669 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF---------GNIGI 1719
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F            GI
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1720 -DVEDEDSDEDEFQITEH---------------------NNFRTFFQALMLLFRSATGEA 1757
             DV  ED        T H                      NF  F  A++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1758 WHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
            W +++               +    G ++ + YFV+ I + SF +LNL + V+   F
Sbjct: 365  WTDVLY-------------WVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 69/291 (23%), Positives = 118/291 (40%), Gaps = 70/291 (24%)

Query: 100  FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
            FEY++   I+ N I LA++ +            ++     F G+F  E  +K+IA    F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273

Query: 160  HKGSYLRNGWNVMDFVVVLTGILATVGTEFD---------LRTLRAVRVLRPLKLVSGIP 210
                Y  + WN  D ++V+  I+    TE +         +   R  RV+R +KL+S   
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGE 1333

Query: 211  SLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPA 270
             ++ +L + +K+   L  + LL+     I+A+IG++ + GK                  A
Sbjct: 1334 GIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI-----------------A 1375

Query: 271  PCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLY----- 325
               T E  R               NN    F     AVL +F+C T E W D++      
Sbjct: 1376 LNDTTEINR---------------NNNFQTFPQ---AVLLLFRCATGEAWQDIMLACMPG 1417

Query: 326  ----------NSNDAS---GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 363
                      NS +     G+++   YFI   ++ +F ++NL + V+   F
Sbjct: 1418 KKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1468


>gi|193794832 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoforom 13 [Homo sapiens]
          Length = 2144

 Score =  778 bits (2009), Expect = 0.0
 Identities = 411/872 (47%), Positives = 568/872 (65%), Gaps = 56/872 (6%)

Query: 1146 IVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEE 1205
            +V  P+  ++   K   K      + PPA    +N   +Q N+N +  P P  E   +E+
Sbjct: 790  LVEKPAVGESKEEKIELKSITADGESPPATK--INMDDLQPNENEDKSPYPNPETTGEED 847

Query: 1206 EEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLCHYILNLRYFEMCIL 1251
            EE+     GP+P              MP  S+ FI S+ N  R  CH I+N   F   IL
Sbjct: 848  EEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLIL 907

Query: 1252 MVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRD 1311
              I +SSI+LAAEDPVQ  + RN++L YFD VFT +FT E+ +KM   G  LH+G++ R+
Sbjct: 908  FFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRN 967

Query: 1312 LWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVV 1371
             +NILD +VVS +L++F    ++    IN +K LRVLRVLRPL+ I R   LK V  CV 
Sbjct: 968  YFNILDLLVVSVSLISFGIQSSA----INVVKILRVLRVLRPLRAINRAKGLKHVVQCVF 1023

Query: 1372 NSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK- 1430
             +++ + NI+IV  L  F+FA + VQLFKGK + C+D SK+ E +C+G Y+ Y+  EV  
Sbjct: 1024 VAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDH 1083

Query: 1431 --ARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMS 1488
               + R W+  +F +DNVL A++ LFTVST EGWP++L  S+D+  E++GP   YR+E+S
Sbjct: 1084 PIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEIS 1143

Query: 1489 IFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHM 1548
            IF+++Y ++  FF +NIFV  +I+TFQEQG++  +   L+KN+R C+++A+ A+PL R++
Sbjct: 1144 IFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYI 1203

Query: 1549 PQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSL 1608
            P+N+   QY++W  V S  FEY +  +I LNTI L M+ YG S  ++ A+ + N++FT L
Sbjct: 1204 PKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGL 1261

Query: 1609 FSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFG--NNFINLSFLRLFRAA 1666
            F++E +LK++AF   +YF DAWN FD + V+GSI DI +TE    N+ I+++F RLFR  
Sbjct: 1262 FTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITENAEENSRISITFFRLFRVM 1321

Query: 1667 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDS 1726
            RL+KLL +G  IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQVFG I ++      
Sbjct: 1322 RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALN------ 1375

Query: 1727 DEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPC-----DKNSGILTRE 1781
              D  +I  +NNF+TF QA++LLFR ATGEAW +IML+C+ GK C       NS      
Sbjct: 1376 --DTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETP 1433

Query: 1782 CGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDP 1841
            CG+ FA FYF+SF  LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDE+ R+WAEYDP
Sbjct: 1434 CGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDP 1493

Query: 1842 AACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALI 1901
             A GRI + D+ +LLR I PPLG GK CPHRVACKRL+ M++P+  D TV FN+TL AL+
Sbjct: 1494 EAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALV 1553

Query: 1902 RTALDIKIAKG--------GADK--------QQMDAELRKEMMAIWPNLSQKTLDLLVTP 1945
            RTAL IK  +G        GA+         +Q + ELR  +  IW   S K LD +V P
Sbjct: 1554 RTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVVPP 1613

Query: 1946 HKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAM 1977
                ++TVGK YA  +I EY+R+ K +K Q +
Sbjct: 1614 AGDDEVTVGKFYATFLIQEYFRKFKKRKEQGL 1645



 Score =  671 bits (1730), Expect = 0.0
 Identities = 383/827 (46%), Positives = 507/827 (61%), Gaps = 64/827 (7%)

Query: 2   ARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQG-----------GQPGAQRMYKQ 50
           + +G   PA +    + AAAG+        GA  S Q            G  G   +   
Sbjct: 18  SNYGSPRPA-HANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTV 76

Query: 51  SMAQRARTMALYNPIPVRQNCLTVNR---SLFLFSEDNVVRKYAKKITEWPPFEYMILAT 107
           S  QR R    Y   P +Q   T  R   +L   +  N +R+    I EW PFE +IL T
Sbjct: 77  SSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLT 133

Query: 108 IIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRN 167
           I ANC+ LA+    P+DD    +  L+  E  F+ IF  EA +K+IA G  FH  +YLRN
Sbjct: 134 IFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRN 193

Query: 168 GWNVMDFVVVLTGILATV----------------GTEFDLRTLRAVRVLRPLKLVSGIPS 211
           GWN++DF++V+ G+ + +                G  FD++ LRA RVLRPL+LVSG+PS
Sbjct: 194 GWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPS 253

Query: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF-EEGTDDIQGES-P 269
           LQVVL SI+KAM+PLL I LL+ F I+I+AIIGLE +MGK H TC+ +EG  D+  E  P
Sbjct: 254 LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 270 APCGTEEP-ARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSN 328
           +PC  E    R C NGT C+P W+GP +GIT FDN  FA+LTVFQCITMEGWTD+LY  N
Sbjct: 314 SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 329 DASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 388
           DA G  W W+YF+ LIIIGSFF+LNLVLGVLSGEF+KERE+ + R  F KLR +QQ+E +
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433

Query: 389 LNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIAS 448
           L GY++WI++AE++    ++   ++  P     R  ++  S+T+ +N E       +  +
Sbjct: 434 LKGYLDWITQAEDIDPENEDEGMDEEKP-----RNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 449 VGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH 508
            G   AR + + +K + S ++ +  R  R   R  VK+  FYW V+ LV LNTL +A  H
Sbjct: 489 CG---ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEH 545

Query: 509 YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIW 568
           YNQP WL++    A    L LF +EM +KMY LG + YF S FN FDC V+ G I E I 
Sbjct: 546 YNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETIL 605

Query: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
              K  +  GISVLR +RLLRIFK+T+YW SL NLV SLLNS++SI SLL LLFLFI++F
Sbjct: 606 VETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIF 665

Query: 629 ALLGMQLFGGQFNFDE-GTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQ-G 686
           +LLGMQLFGG+FNFDE  T  + FD FP +++TVFQILTGEDWN VMYDGI + GG    
Sbjct: 666 SLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 687 GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEV 746
           GM+  IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EEEE   +K         
Sbjct: 726 GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERK--------- 776

Query: 747 AEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREA 793
                   A  +   K+Q+  +KPA  V E +  ++  +++ A  E+
Sbjct: 777 ------KLARTASPEKKQELVEKPA--VGESKEEKIELKSITADGES 815



 Score =  202 bits (513), Expect = 4e-51
 Identities = 176/705 (24%), Positives = 317/705 (44%), Gaps = 120/705 (17%)

Query: 1200 EEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSI 1259
            + K+++    + +       P  ++  L+  NP+RR C  I+  + FE+ IL+ I  + +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1260 ALAAEDPV---QPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNIL 1316
            ALA   P      NA  +N+ R  +Y+F  +FT E  +K+I  GL+ H  AY R+ WN+L
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV-EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198

Query: 1317 DFIVVSGALVAFAFTGNSKGKDINT---------IKSLRVLRVLRPLKTIKRLPKLKAVF 1367
            DFI+V   L +      +K    N          +K+LR  RVLRPL+ +  +P L+ V 
Sbjct: 199  DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258

Query: 1368 DCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC---------- 1417
            + ++ ++  + +I ++ +  + I+A++ ++LF GK  H T  ++E   D           
Sbjct: 259  NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK-MHKTCYNQEGIADVPAEDDPSPCA 317

Query: 1418 --RGKYLLYEKNEVKARDREWKKYEF-HYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
               G     +   V     +  K+   ++DN  +A+LT+F   T EGW  VL    DA  
Sbjct: 318  LETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAV- 376

Query: 1475 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KMMEEY 1525
                     R    I++V   ++  FF +N+ + ++   F ++       GD  K+ E+ 
Sbjct: 377  --------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428

Query: 1526 SLEKNERACIDFAISA---------------KPLTRHMP--------------------- 1549
             LE++ +  +D+   A               KP    MP                     
Sbjct: 429  QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 1550 ----------QNKQSFQYRMWQ---------FVVSPPFEYTIMAMIALNTIVLMMKFYGA 1590
                      ++K S  +R W           V S  F + ++ ++ LNT+ +  + Y  
Sbjct: 489  CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548

Query: 1591 SVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITD-ILVTE 1649
                       N    +LF+ E +LK+ + G+  YF   +N FD   V G I + ILV  
Sbjct: 549  PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 1650 FGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAII 1709
               + + +S LR  R  R+ K+ R   ++  L+ + + S +++  + LL+ +   I++++
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 1710 GMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGK 1769
            GMQ+FG           + DE Q T  + F  F Q+L+ +F+  TGE W+++M   +   
Sbjct: 669  GMQLFGG--------KFNFDEMQ-TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAY 719

Query: 1770 PCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
                  G+L           YF+  +F+C ++++LN+F+A+ +DN
Sbjct: 720  GGPSFPGML--------VCIYFI-ILFICGNYILLNVFLAIAVDN 755



 Score =  144 bits (362), Expect = 1e-33
 Identities = 179/785 (22%), Positives = 325/785 (41%), Gaps = 161/785 (20%)

Query: 33   AGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAK 92
            AGG  +G   GA+  ++ S ++ +R    +N    R+ C    +S       NV      
Sbjct: 480  AGGDIEGENCGARLAHRISKSKFSRYWRRWNRF-CRRKCRAAVKS-------NV------ 525

Query: 93   KITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKI 152
                   F ++++  +  N + +A E +   +    ++E  D      + +F  E  +K+
Sbjct: 526  -------FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKM 575

Query: 153  IALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------FDLRTLRAVRVLRPLKLV 206
             +LG      +Y  + +N  D  VV  GIL T+  E        +  LR VR+LR  K+ 
Sbjct: 576  YSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKIT 631

Query: 207  SGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQG 266
                SL  ++ S++ ++  +  + LLLF  I+IF+++G++ + GKF+        D++Q 
Sbjct: 632  RYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF-------DEMQT 684

Query: 267  ESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYN 326
                                            + FDN   ++LTVFQ +T E W  ++Y+
Sbjct: 685  RR------------------------------STFDNFPQSLLTVFQILTGEDWNSVMYD 714

Query: 327  SNDASGNT-----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERE 368
               A G          +YFI L I G++ +LN+ L +     A             +E+E
Sbjct: 715  GIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKE 774

Query: 369  RVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIK- 427
            R +  R     ++Q+ +E+   G     SK E++ L     DGE   P    +    ++ 
Sbjct: 775  RKKLARTASPEKKQELVEKPAVGE----SKEEKIELKSITADGES--PPATKINMDDLQP 828

Query: 428  ---KSKTDLLNPEEA--EDQLADIASVGS---PFARASIKSAKL---ENSTFF-HKKERR 475
               + K+   NPE    ED+      VG    P +   +K   +   E S FF      R
Sbjct: 829  NENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNR 888

Query: 476  MRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ-PEWLSDFLYYAEFIFLGLFMSEM 534
             R    R+V    F   +L  + L+++ +A     Q   + +  L+Y + +F  +F  E+
Sbjct: 889  FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEI 948

Query: 535  FIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRI 590
             +KM   G       +  + FN  D  V+  S+       I+      + +LR LR+LR 
Sbjct: 949  ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRP 1005

Query: 591  FKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQ-FNFDEGTPPT 649
             +       L+++V  +  ++++I +++ +  L   +FA +G+QLF G+ +   + +  T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 650  -------------------------------NFDTFPAAIMTVFQILTGEDWNEVMYDGI 678
                                           +FD   AA+M +F + T E W E++Y  I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 679  KSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEA 733
             S    +G +       SI+FI+  +   + ++N+F+   +        +T  EQ E+E 
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEY 1177

Query: 734  ANQKL 738
             N +L
Sbjct: 1178 KNCEL 1182



 Score =  115 bits (288), Expect = 5e-25
 Identities = 74/281 (26%), Positives = 138/281 (49%), Gaps = 29/281 (10%)

Query: 472  KERRMRFYIRR---------MVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 522
            K R +R YI +         +V +  F + +  L+ LNT+C+A+ HY Q       +   
Sbjct: 1195 KARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNIL 1254

Query: 523  EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEV-IWAVIKPGTSFGISV 581
              +F GLF  EM +K+     + YF  ++N FD  +++GSI ++ I    +  +   I+ 
Sbjct: 1255 NMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITENAEENSRISITF 1314

Query: 582  LRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG--GQ 639
             R  R++R+ K+      +R L+ + + S +++  +  L+ +   ++A++GMQ+FG    
Sbjct: 1315 FRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL 1374

Query: 640  FNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMY-------------DGIKSQGGVQG 686
             +  E     NF TFP A++ +F+  TGE W ++M                  ++G    
Sbjct: 1375 NDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPC 1434

Query: 687  GMVFSI-YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
            G  F++ YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1435 GSSFAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1472



 Score =  114 bits (285), Expect = 1e-24
 Identities = 96/331 (29%), Positives = 162/331 (48%), Gaps = 33/331 (9%)

Query: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
            + F+FS +N  R    +I     F  +IL  I+ + I LA E   P    +  +  L   
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 936

Query: 137  EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV   ++ + G +      ++
Sbjct: 937  DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLI-SFGIQSSAINVVK 995

Query: 193  TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      +FA IG++ + GK 
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 253  HTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----WEGPNNGITQFDNILFA 307
            +T        D   ++ A C  +    T  +G    P      WE   N    FDN+L A
Sbjct: 1056 YT------CSDSSKQTEAEC--KGNYITYKDGEVDHPIIQPRSWE---NSKFDFDNVLAA 1104

Query: 308  VLTVFQCITMEGWTDLLYNSNDA----SGNTWNW-----LYFIPLIIIGSFFMLNLVLGV 358
            ++ +F   T EGW +LLY S D+     G  +N+     ++FI  III +FFM+N+ +G 
Sbjct: 1105 MMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGF 1164

Query: 359  LSGEFAKERERVENRRAFLKLRRQQQIEREL 389
            +   F ++ E+ E +   L   ++Q +E  L
Sbjct: 1165 VIVTFQEQGEQ-EYKNCELDKNQRQCVEYAL 1194



 Score = 82.0 bits (201), Expect = 6e-15
 Identities = 73/297 (24%), Positives = 130/297 (43%), Gaps = 62/297 (20%)

Query: 1567 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1623
            PFE  I+  I  N + L +        S A  + L     +F  +F++E  LKV+A+G+L
Sbjct: 125  PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1624 ----NYFRDAWNIFDFVTVLGSITDILVTEF----GNNFI-------NLSFLRLFRAARL 1668
                 Y R+ WN+ DF+ V+  +   ++ +     G N +       ++  LR FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1669 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF---------GNIGI 1719
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F            GI
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1720 -DVEDEDSDEDEFQITEH---------------------NNFRTFFQALMLLFRSATGEA 1757
             DV  ED        T H                      NF  F  A++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1758 WHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
            W +++               +    G ++ + YFV+ I + SF +LNL + V+   F
Sbjct: 365  WTDVLY-------------WVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 69/289 (23%), Positives = 117/289 (40%), Gaps = 68/289 (23%)

Query: 100  FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
            FEY++   I+ N I LA++ +            ++     F G+F  E  +K+IA    F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273

Query: 160  HKGSYLRNGWNVMDFVVVLTGILATVGTE-------FDLRTLRAVRVLRPLKLVSGIPSL 212
                Y  + WN  D ++V+  I+    TE         +   R  RV+R +KL+S    +
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITENAEENSRISITFFRLFRVMRLVKLLSRGEGI 1333

Query: 213  QVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPC 272
            + +L + +K+   L  + LL+     I+A+IG++ + GK                  A  
Sbjct: 1334 RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI-----------------ALN 1375

Query: 273  GTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLY------- 325
             T E  R               NN    F     AVL +F+C T E W D++        
Sbjct: 1376 DTTEINR---------------NNNFQTFPQ---AVLLLFRCATGEAWQDIMLACMPGKK 1417

Query: 326  --------NSNDAS---GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 363
                    NS +     G+++   YFI   ++ +F ++NL + V+   F
Sbjct: 1418 CAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1466


>gi|193788532 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 11 [Homo sapiens]
          Length = 2146

 Score =  778 bits (2009), Expect = 0.0
 Identities = 411/874 (47%), Positives = 568/874 (64%), Gaps = 58/874 (6%)

Query: 1146 IVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEE 1205
            +V  P+  ++   K   K      + PPA    +N   +Q N+N +  P P  E   +E+
Sbjct: 790  LVEKPAVGESKEEKIELKSITADGESPPATK--INMDDLQPNENEDKSPYPNPETTGEED 847

Query: 1206 EEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLCHYILNLRYFEMCIL 1251
            EE+     GP+P              MP  S+ FI S+ N  R  CH I+N   F   IL
Sbjct: 848  EEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLIL 907

Query: 1252 MVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRD 1311
              I +SSI+LAAEDPVQ  + RN++L YFD VFT +FT E+ +KM   G  LH+G++ R+
Sbjct: 908  FFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRN 967

Query: 1312 LWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVV 1371
             +NILD +VVS +L++F    ++    IN +K LRVLRVLRPL+ I R   LK V  CV 
Sbjct: 968  YFNILDLLVVSVSLISFGIQSSA----INVVKILRVLRVLRPLRAINRAKGLKHVVQCVF 1023

Query: 1372 NSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK- 1430
             +++ + NI+IV  L  F+FA + VQLFKGK + C+D SK+ E +C+G Y+ Y+  EV  
Sbjct: 1024 VAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDH 1083

Query: 1431 --ARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMS 1488
               + R W+  +F +DNVL A++ LFTVST EGWP++L  S+D+  E++GP   YR+E+S
Sbjct: 1084 PIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEIS 1143

Query: 1489 IFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHM 1548
            IF+++Y ++  FF +NIFV  +I+TFQEQG++  +   L+KN+R C+++A+ A+PL R++
Sbjct: 1144 IFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYI 1203

Query: 1549 PQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSL 1608
            P+N+   QY++W  V S  FEY +  +I LNTI L M+ YG S  ++ A+ + N++FT L
Sbjct: 1204 PKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGL 1261

Query: 1609 FSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGN----NFINLSFLRLFR 1664
            F++E +LK++AF   +YF DAWN FD + V+GSI DI +TE  N    + I+++F RLFR
Sbjct: 1262 FTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFR 1321

Query: 1665 AARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDE 1724
              RL+KLL +G  IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQVFG I ++    
Sbjct: 1322 VMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALN---- 1377

Query: 1725 DSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPC-----DKNSGILT 1779
                D  +I  +NNF+TF QA++LLFR ATGEAW +IML+C+ GK C       NS    
Sbjct: 1378 ----DTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGE 1433

Query: 1780 RECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEY 1839
              CG+ FA FYF+SF  LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDE+ R+WAEY
Sbjct: 1434 TPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEY 1493

Query: 1840 DPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMA 1899
            DP A GRI + D+ +LLR I PPLG GK CPHRVACKRL+ M++P+  D TV FN+TL A
Sbjct: 1494 DPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFA 1553

Query: 1900 LIRTALDIKIAKG--------GADK--------QQMDAELRKEMMAIWPNLSQKTLDLLV 1943
            L+RTAL IK  +G        GA+         +Q + ELR  +  IW   S K LD +V
Sbjct: 1554 LVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVV 1613

Query: 1944 TPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAM 1977
             P    ++TVGK YA  +I EY+R+ K +K Q +
Sbjct: 1614 PPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGL 1647



 Score =  671 bits (1730), Expect = 0.0
 Identities = 383/827 (46%), Positives = 507/827 (61%), Gaps = 64/827 (7%)

Query: 2   ARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQG-----------GQPGAQRMYKQ 50
           + +G   PA +    + AAAG+        GA  S Q            G  G   +   
Sbjct: 18  SNYGSPRPA-HANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTV 76

Query: 51  SMAQRARTMALYNPIPVRQNCLTVNR---SLFLFSEDNVVRKYAKKITEWPPFEYMILAT 107
           S  QR R    Y   P +Q   T  R   +L   +  N +R+    I EW PFE +IL T
Sbjct: 77  SSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLT 133

Query: 108 IIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRN 167
           I ANC+ LA+    P+DD    +  L+  E  F+ IF  EA +K+IA G  FH  +YLRN
Sbjct: 134 IFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRN 193

Query: 168 GWNVMDFVVVLTGILATV----------------GTEFDLRTLRAVRVLRPLKLVSGIPS 211
           GWN++DF++V+ G+ + +                G  FD++ LRA RVLRPL+LVSG+PS
Sbjct: 194 GWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPS 253

Query: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF-EEGTDDIQGES-P 269
           LQVVL SI+KAM+PLL I LL+ F I+I+AIIGLE +MGK H TC+ +EG  D+  E  P
Sbjct: 254 LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 270 APCGTEEP-ARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSN 328
           +PC  E    R C NGT C+P W+GP +GIT FDN  FA+LTVFQCITMEGWTD+LY  N
Sbjct: 314 SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 329 DASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 388
           DA G  W W+YF+ LIIIGSFF+LNLVLGVLSGEF+KERE+ + R  F KLR +QQ+E +
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433

Query: 389 LNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIAS 448
           L GY++WI++AE++    ++   ++  P     R  ++  S+T+ +N E       +  +
Sbjct: 434 LKGYLDWITQAEDIDPENEDEGMDEEKP-----RNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 449 VGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH 508
            G   AR + + +K + S ++ +  R  R   R  VK+  FYW V+ LV LNTL +A  H
Sbjct: 489 CG---ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEH 545

Query: 509 YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIW 568
           YNQP WL++    A    L LF +EM +KMY LG + YF S FN FDC V+ G I E I 
Sbjct: 546 YNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETIL 605

Query: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
              K  +  GISVLR +RLLRIFK+T+YW SL NLV SLLNS++SI SLL LLFLFI++F
Sbjct: 606 VETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIF 665

Query: 629 ALLGMQLFGGQFNFDE-GTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQ-G 686
           +LLGMQLFGG+FNFDE  T  + FD FP +++TVFQILTGEDWN VMYDGI + GG    
Sbjct: 666 SLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 687 GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEV 746
           GM+  IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EEEE   +K         
Sbjct: 726 GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERK--------- 776

Query: 747 AEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREA 793
                   A  +   K+Q+  +KPA  V E +  ++  +++ A  E+
Sbjct: 777 ------KLARTASPEKKQELVEKPA--VGESKEEKIELKSITADGES 815



 Score =  202 bits (513), Expect = 4e-51
 Identities = 176/705 (24%), Positives = 317/705 (44%), Gaps = 120/705 (17%)

Query: 1200 EEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSI 1259
            + K+++    + +       P  ++  L+  NP+RR C  I+  + FE+ IL+ I  + +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1260 ALAAEDPV---QPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNIL 1316
            ALA   P      NA  +N+ R  +Y+F  +FT E  +K+I  GL+ H  AY R+ WN+L
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV-EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198

Query: 1317 DFIVVSGALVAFAFTGNSKGKDINT---------IKSLRVLRVLRPLKTIKRLPKLKAVF 1367
            DFI+V   L +      +K    N          +K+LR  RVLRPL+ +  +P L+ V 
Sbjct: 199  DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258

Query: 1368 DCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC---------- 1417
            + ++ ++  + +I ++ +  + I+A++ ++LF GK  H T  ++E   D           
Sbjct: 259  NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK-MHKTCYNQEGIADVPAEDDPSPCA 317

Query: 1418 --RGKYLLYEKNEVKARDREWKKYEF-HYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
               G     +   V     +  K+   ++DN  +A+LT+F   T EGW  VL    DA  
Sbjct: 318  LETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAV- 376

Query: 1475 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KMMEEY 1525
                     R    I++V   ++  FF +N+ + ++   F ++       GD  K+ E+ 
Sbjct: 377  --------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428

Query: 1526 SLEKNERACIDFAISA---------------KPLTRHMP--------------------- 1549
             LE++ +  +D+   A               KP    MP                     
Sbjct: 429  QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 1550 ----------QNKQSFQYRMWQ---------FVVSPPFEYTIMAMIALNTIVLMMKFYGA 1590
                      ++K S  +R W           V S  F + ++ ++ LNT+ +  + Y  
Sbjct: 489  CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548

Query: 1591 SVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITD-ILVTE 1649
                       N    +LF+ E +LK+ + G+  YF   +N FD   V G I + ILV  
Sbjct: 549  PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 1650 FGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAII 1709
               + + +S LR  R  R+ K+ R   ++  L+ + + S +++  + LL+ +   I++++
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 1710 GMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGK 1769
            GMQ+FG           + DE Q T  + F  F Q+L+ +F+  TGE W+++M   +   
Sbjct: 669  GMQLFGG--------KFNFDEMQ-TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAY 719

Query: 1770 PCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
                  G+L           YF+  +F+C ++++LN+F+A+ +DN
Sbjct: 720  GGPSFPGML--------VCIYFI-ILFICGNYILLNVFLAIAVDN 755



 Score =  144 bits (362), Expect = 1e-33
 Identities = 179/785 (22%), Positives = 325/785 (41%), Gaps = 161/785 (20%)

Query: 33   AGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAK 92
            AGG  +G   GA+  ++ S ++ +R    +N    R+ C    +S       NV      
Sbjct: 480  AGGDIEGENCGARLAHRISKSKFSRYWRRWNRF-CRRKCRAAVKS-------NV------ 525

Query: 93   KITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKI 152
                   F ++++  +  N + +A E +   +    ++E  D      + +F  E  +K+
Sbjct: 526  -------FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKM 575

Query: 153  IALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------FDLRTLRAVRVLRPLKLV 206
             +LG      +Y  + +N  D  VV  GIL T+  E        +  LR VR+LR  K+ 
Sbjct: 576  YSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKIT 631

Query: 207  SGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQG 266
                SL  ++ S++ ++  +  + LLLF  I+IF+++G++ + GKF+        D++Q 
Sbjct: 632  RYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF-------DEMQT 684

Query: 267  ESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYN 326
                                            + FDN   ++LTVFQ +T E W  ++Y+
Sbjct: 685  RR------------------------------STFDNFPQSLLTVFQILTGEDWNSVMYD 714

Query: 327  SNDASGNT-----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERE 368
               A G          +YFI L I G++ +LN+ L +     A             +E+E
Sbjct: 715  GIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKE 774

Query: 369  RVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIK- 427
            R +  R     ++Q+ +E+   G     SK E++ L     DGE   P    +    ++ 
Sbjct: 775  RKKLARTASPEKKQELVEKPAVGE----SKEEKIELKSITADGES--PPATKINMDDLQP 828

Query: 428  ---KSKTDLLNPEEA--EDQLADIASVGS---PFARASIKSAKL---ENSTFF-HKKERR 475
               + K+   NPE    ED+      VG    P +   +K   +   E S FF      R
Sbjct: 829  NENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNR 888

Query: 476  MRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ-PEWLSDFLYYAEFIFLGLFMSEM 534
             R    R+V    F   +L  + L+++ +A     Q   + +  L+Y + +F  +F  E+
Sbjct: 889  FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEI 948

Query: 535  FIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRI 590
             +KM   G       +  + FN  D  V+  S+       I+      + +LR LR+LR 
Sbjct: 949  ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRP 1005

Query: 591  FKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQ-FNFDEGTPPT 649
             +       L+++V  +  ++++I +++ +  L   +FA +G+QLF G+ +   + +  T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 650  -------------------------------NFDTFPAAIMTVFQILTGEDWNEVMYDGI 678
                                           +FD   AA+M +F + T E W E++Y  I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 679  KSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEA 733
             S    +G +       SI+FI+  +   + ++N+F+   +        +T  EQ E+E 
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEY 1177

Query: 734  ANQKL 738
             N +L
Sbjct: 1178 KNCEL 1182



 Score =  114 bits (286), Expect = 8e-25
 Identities = 73/283 (25%), Positives = 138/283 (48%), Gaps = 31/283 (10%)

Query: 472  KERRMRFYIRR---------MVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 522
            K R +R YI +         +V +  F + +  L+ LNT+C+A+ HY Q       +   
Sbjct: 1195 KARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNIL 1254

Query: 523  EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVI---KPGTSFGI 579
              +F GLF  EM +K+     + YF  ++N FD  +++GSI ++    +   +  +   I
Sbjct: 1255 NMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISI 1314

Query: 580  SVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG-- 637
            +  R  R++R+ K+      +R L+ + + S +++  +  L+ +   ++A++GMQ+FG  
Sbjct: 1315 TFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKI 1374

Query: 638  GQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMY-------------DGIKSQGGV 684
               +  E     NF TFP A++ +F+  TGE W ++M                  ++G  
Sbjct: 1375 ALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGET 1434

Query: 685  QGGMVFSI-YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
              G  F++ YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1435 PCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1474



 Score =  114 bits (285), Expect = 1e-24
 Identities = 96/331 (29%), Positives = 162/331 (48%), Gaps = 33/331 (9%)

Query: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
            + F+FS +N  R    +I     F  +IL  I+ + I LA E   P    +  +  L   
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 936

Query: 137  EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV   ++ + G +      ++
Sbjct: 937  DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLI-SFGIQSSAINVVK 995

Query: 193  TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      +FA IG++ + GK 
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 253  HTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----WEGPNNGITQFDNILFA 307
            +T        D   ++ A C  +    T  +G    P      WE   N    FDN+L A
Sbjct: 1056 YT------CSDSSKQTEAEC--KGNYITYKDGEVDHPIIQPRSWE---NSKFDFDNVLAA 1104

Query: 308  VLTVFQCITMEGWTDLLYNSNDA----SGNTWNW-----LYFIPLIIIGSFFMLNLVLGV 358
            ++ +F   T EGW +LLY S D+     G  +N+     ++FI  III +FFM+N+ +G 
Sbjct: 1105 MMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGF 1164

Query: 359  LSGEFAKERERVENRRAFLKLRRQQQIEREL 389
            +   F ++ E+ E +   L   ++Q +E  L
Sbjct: 1165 VIVTFQEQGEQ-EYKNCELDKNQRQCVEYAL 1194



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 79/311 (25%), Positives = 143/311 (45%), Gaps = 41/311 (13%)

Query: 1234 RRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMV 1293
            RR C   +    F   ++ ++ ++++ +A+E   QPN     V    +     +FT EM+
Sbjct: 514  RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW-LTEVQDTANKALLALFTAEML 572

Query: 1294 IKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRP 1353
            +KM  LGL     AYF  L+N  D  VV G ++            +  I  LR +R+LR 
Sbjct: 573  LKMYSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLG-ISVLRCVRLLRI 627

Query: 1354 LKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEF 1413
             K  +    L  +   ++NS++++ ++L++  LF+ IF+++ +QLF GKF          
Sbjct: 628  FKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF---------- 677

Query: 1414 EKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDAT 1473
                         +E++ R          +DN   +LLT+F + TGE W  V+    D  
Sbjct: 678  -----------NFDEMQTRRST-------FDNFPQSLLTVFQILTGEDWNSVM---YDGI 716

Query: 1474 FENQGPS-PGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNER 1532
                GPS PG  M + I++++ F+   +  +N+F+A+ +    +  + +      E+ E+
Sbjct: 717  MAYGGPSFPG--MLVCIYFIILFICGNYILLNVFLAIAVDNLAD-AESLTSAQKEEEEEK 773

Query: 1533 ACIDFAISAKP 1543
                 A +A P
Sbjct: 774  ERKKLARTASP 784



 Score = 82.0 bits (201), Expect = 6e-15
 Identities = 73/297 (24%), Positives = 130/297 (43%), Gaps = 62/297 (20%)

Query: 1567 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1623
            PFE  I+  I  N + L +        S A  + L     +F  +F++E  LKV+A+G+L
Sbjct: 125  PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1624 ----NYFRDAWNIFDFVTVLGSITDILVTEF----GNNFI-------NLSFLRLFRAARL 1668
                 Y R+ WN+ DF+ V+  +   ++ +     G N +       ++  LR FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1669 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF---------GNIGI 1719
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F            GI
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1720 -DVEDEDSDEDEFQITEH---------------------NNFRTFFQALMLLFRSATGEA 1757
             DV  ED        T H                      NF  F  A++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1758 WHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
            W +++               +    G ++ + YFV+ I + SF +LNL + V+   F
Sbjct: 365  WTDVLY-------------WVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 69/291 (23%), Positives = 118/291 (40%), Gaps = 70/291 (24%)

Query: 100  FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
            FEY++   I+ N I LA++ +            ++     F G+F  E  +K+IA    F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273

Query: 160  HKGSYLRNGWNVMDFVVVLTGILATVGTEFD---------LRTLRAVRVLRPLKLVSGIP 210
                Y  + WN  D ++V+  I+    TE +         +   R  RV+R +KL+S   
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGE 1333

Query: 211  SLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPA 270
             ++ +L + +K+   L  + LL+     I+A+IG++ + GK                  A
Sbjct: 1334 GIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI-----------------A 1375

Query: 271  PCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLY----- 325
               T E  R               NN    F     AVL +F+C T E W D++      
Sbjct: 1376 LNDTTEINR---------------NNNFQTFPQ---AVLLLFRCATGEAWQDIMLACMPG 1417

Query: 326  ----------NSNDAS---GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 363
                      NS +     G+++   YFI   ++ +F ++NL + V+   F
Sbjct: 1418 KKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1468


>gi|193788544 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 19 [Homo sapiens]
          Length = 2135

 Score =  777 bits (2006), Expect = 0.0
 Identities = 406/869 (46%), Positives = 565/869 (65%), Gaps = 56/869 (6%)

Query: 1146 IVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEE 1205
            +V  P+  ++   K   K      + PPA    +N   +Q N+N +  P P  E   +E+
Sbjct: 787  LVEKPAVGESKEEKIELKSITADGESPPATK--INMDDLQPNENEDKSPYPNPETTGEED 844

Query: 1206 EEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLCHYILNLRYFEMCIL 1251
            EE+     GP+P              MP  S+ FI S+ N  R  CH I+N   F   IL
Sbjct: 845  EEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLIL 904

Query: 1252 MVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRD 1311
              I +SSI+LAAEDPVQ  + RN++L YFD VFT +FT E+ +KM   G  LH+G++ R+
Sbjct: 905  FFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRN 964

Query: 1312 LWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVV 1371
             +NILD +VVS +L++F    ++    IN +K LRVLRVLRPL+ I R   LK V  CV 
Sbjct: 965  YFNILDLLVVSVSLISFGIQSSA----INVVKILRVLRVLRPLRAINRAKGLKHVVQCVF 1020

Query: 1372 NSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK- 1430
             +++ + NI+IV  L  F+FA + VQLFKGK + C+D SK+ E +C+G Y+ Y+  EV  
Sbjct: 1021 VAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDH 1080

Query: 1431 --ARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMS 1488
               + R W+  +F +DNVL A++ LFTVST EGWP++L  S+D+  E++GP   YR+E+S
Sbjct: 1081 PIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEIS 1140

Query: 1489 IFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHM 1548
            IF+++Y ++  FF +NIFV  +I+TFQEQG++  +   L+KN+R C+++A+ A+PL R++
Sbjct: 1141 IFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYI 1200

Query: 1549 PQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSL 1608
            P+N+   QY++W  V S  FEY +  +I LNTI L M+ YG S  ++ A+ + N++FT L
Sbjct: 1201 PKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGL 1258

Query: 1609 FSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFG---------------NN 1653
            F++E +LK++AF    YF D WN+FDF+ V+GSI D++++E                 N+
Sbjct: 1259 FTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENS 1318

Query: 1654 FINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQV 1713
             I+++F RLFR  RL+KLL +G  IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQV
Sbjct: 1319 RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV 1378

Query: 1714 FGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPC-- 1771
            FG I ++        D  +I  +NNF+TF QA++LLFR ATGEAW +IML+C+ GK C  
Sbjct: 1379 FGKIALN--------DTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAP 1430

Query: 1772 ---DKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHH 1828
                 NS      CG+ FA FYF+SF  LC+FL++NLFVAVIMDNF+YLTRD SILGPHH
Sbjct: 1431 ESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHH 1490

Query: 1829 LDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADD 1888
            LDE+ R+WAEYDP A GRI + D+ +LLR I PPLG GK CPHRVACKRL+ M++P+  D
Sbjct: 1491 LDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSD 1550

Query: 1889 NTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKS 1948
             TV FN+TL AL+RTAL IK      + +Q + ELR  +  IW   S K LD +V P   
Sbjct: 1551 GTVMFNATLFALVRTALRIKTE---GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGD 1607

Query: 1949 TDLTVGKIYAAMMIMEYYRQSKAKKLQAM 1977
             ++TVGK YA  +I EY+R+ K +K Q +
Sbjct: 1608 DEVTVGKFYATFLIQEYFRKFKKRKEQGL 1636



 Score =  665 bits (1717), Expect = 0.0
 Identities = 381/826 (46%), Positives = 505/826 (61%), Gaps = 65/826 (7%)

Query: 2   ARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQG-----------GQPGAQRMYKQ 50
           + +G   PA +    + AAAG+        GA  S Q            G  G   +   
Sbjct: 18  SNYGSPRPA-HANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTV 76

Query: 51  SMAQRARTMALYNPIPVRQNCLTVNR---SLFLFSEDNVVRKYAKKITEWPPFEYMILAT 107
           S  QR R    Y   P +Q   T  R   +L   +  N +R+    I EW PFE +IL T
Sbjct: 77  SSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLT 133

Query: 108 IIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRN 167
           I ANC+ LA+    P+DD    +  L+  E  F+ IF  EA +K+IA G  FH  +YLRN
Sbjct: 134 IFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRN 193

Query: 168 GWNVMDFVVVLTGILATV----------------GTEFDLRTLRAVRVLRPLKLVSGIPS 211
           GWN++DF++V+ G+ + +                G  FD++ LRA RVLRPL+LVSG+PS
Sbjct: 194 GWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPS 253

Query: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGES-PA 270
           LQVVL SI+KAM+PLL I LL+ F I+I+AIIGLE +MGK H TC+ +  + I  E  P+
Sbjct: 254 LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQ--EGIAAEDDPS 311

Query: 271 PCGTEEP-ARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSND 329
           PC  E    R C NGT C+P W+GP +GIT FDN  FA+LTVFQCITMEGWTD+LY  ND
Sbjct: 312 PCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVND 371

Query: 330 ASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIEREL 389
           A G  W W+YF+ LIIIGSFF+LNLVLGVLSGEF+KERE+ + R  F KLR +QQ+E +L
Sbjct: 372 AVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDL 431

Query: 390 NGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIASV 449
            GY++WI++AE++    ++   ++  P     R  ++  S+T+ +N E       +  + 
Sbjct: 432 KGYLDWITQAEDIDPENEDEGMDEEKP-----RNMSMPTSETESVNTENVAGGDIEGENC 486

Query: 450 GSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHY 509
           G   AR + + +K + S ++ +  R  R   R  VK+  FYW V+ LV LNTL +A  HY
Sbjct: 487 G---ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHY 543

Query: 510 NQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWA 569
           NQP WL++    A    L LF +EM +KMY LG + YF S FN FDC V+ G I E I  
Sbjct: 544 NQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILV 603

Query: 570 VIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFA 629
             K  +  GISVLR +RLLRIFK+T+YW SL NLV SLLNS++SI SLL LLFLFI++F+
Sbjct: 604 ETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFS 663

Query: 630 LLGMQLFGGQFNFDE-GTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQ-GG 687
           LLGMQLFGG+FNFDE  T  + FD FP +++TVFQILTGEDWN VMYDGI + GG    G
Sbjct: 664 LLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPG 723

Query: 688 MVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEVA 747
           M+  IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EEEE   +K          
Sbjct: 724 MLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERK---------- 773

Query: 748 EVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREA 793
                  A  +   K+Q+  +KPA  V E +  ++  +++ A  E+
Sbjct: 774 -----KLARTASPEKKQELVEKPA--VGESKEEKIELKSITADGES 812



 Score =  202 bits (514), Expect = 3e-51
 Identities = 174/701 (24%), Positives = 317/701 (45%), Gaps = 115/701 (16%)

Query: 1200 EEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSI 1259
            + K+++    + +       P  ++  L+  NP+RR C  I+  + FE+ IL+ I  + +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1260 ALAAEDPV---QPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNIL 1316
            ALA   P      NA  +N+ R  +Y+F  +FT E  +K+I  GL+ H  AY R+ WN+L
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV-EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198

Query: 1317 DFIVVSGALVAFAFTGNSKGKDINT---------IKSLRVLRVLRPLKTIKRLPKLKAVF 1367
            DFI+V   L +      +K    N          +K+LR  RVLRPL+ +  +P L+ V 
Sbjct: 199  DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258

Query: 1368 DCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFH-CTDESKEFEKDCRGKYLLYEK 1426
            + ++ ++  + +I ++ +  + I+A++ ++LF GK    C ++     +D      L   
Sbjct: 259  NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIAAEDDPSPCALETG 318

Query: 1427 NEVKARDRE-----W---KKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQG 1478
            +  + ++       W   K    ++DN  +A+LT+F   T EGW  VL    DA      
Sbjct: 319  HGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAV----- 373

Query: 1479 PSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KMMEEYSLEK 1529
                 R    I++V   ++  FF +N+ + ++   F ++       GD  K+ E+  LE+
Sbjct: 374  ----GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEE 429

Query: 1530 NERACIDFAISA---------------KPLTRHMP------------------------- 1549
            + +  +D+   A               KP    MP                         
Sbjct: 430  DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 489

Query: 1550 ------QNKQSFQYRMWQ---------FVVSPPFEYTIMAMIALNTIVLMMKFYGASVAY 1594
                  ++K S  +R W           V S  F + ++ ++ LNT+ +  + Y      
Sbjct: 490  LAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWL 549

Query: 1595 ENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITD-ILVTEFGNN 1653
                   N    +LF+ E +LK+ + G+  YF   +N FD   V G I + ILV     +
Sbjct: 550  TEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMS 609

Query: 1654 FINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQV 1713
             + +S LR  R  R+ K+ R   ++  L+ + + S +++  + LL+ +   I++++GMQ+
Sbjct: 610  PLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQL 669

Query: 1714 FGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDK 1773
            FG           + DE Q T  + F  F Q+L+ +F+  TGE W+++M   +       
Sbjct: 670  FGG--------KFNFDEMQ-TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPS 720

Query: 1774 NSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
              G+L           YF+  +F+C ++++LN+F+A+ +DN
Sbjct: 721  FPGML--------VCIYFI-ILFICGNYILLNVFLAIAVDN 752



 Score =  144 bits (362), Expect = 1e-33
 Identities = 179/785 (22%), Positives = 325/785 (41%), Gaps = 161/785 (20%)

Query: 33   AGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAK 92
            AGG  +G   GA+  ++ S ++ +R    +N    R+ C    +S       NV      
Sbjct: 477  AGGDIEGENCGARLAHRISKSKFSRYWRRWNRF-CRRKCRAAVKS-------NV------ 522

Query: 93   KITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKI 152
                   F ++++  +  N + +A E +   +    ++E  D      + +F  E  +K+
Sbjct: 523  -------FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKM 572

Query: 153  IALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------FDLRTLRAVRVLRPLKLV 206
             +LG      +Y  + +N  D  VV  GIL T+  E        +  LR VR+LR  K+ 
Sbjct: 573  YSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKIT 628

Query: 207  SGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQG 266
                SL  ++ S++ ++  +  + LLLF  I+IF+++G++ + GKF+        D++Q 
Sbjct: 629  RYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF-------DEMQT 681

Query: 267  ESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYN 326
                                            + FDN   ++LTVFQ +T E W  ++Y+
Sbjct: 682  RR------------------------------STFDNFPQSLLTVFQILTGEDWNSVMYD 711

Query: 327  SNDASGNT-----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERE 368
               A G          +YFI L I G++ +LN+ L +     A             +E+E
Sbjct: 712  GIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKE 771

Query: 369  RVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIK- 427
            R +  R     ++Q+ +E+   G     SK E++ L     DGE   P    +    ++ 
Sbjct: 772  RKKLARTASPEKKQELVEKPAVGE----SKEEKIELKSITADGES--PPATKINMDDLQP 825

Query: 428  ---KSKTDLLNPEEA--EDQLADIASVGS---PFARASIKSAKL---ENSTFF-HKKERR 475
               + K+   NPE    ED+      VG    P +   +K   +   E S FF      R
Sbjct: 826  NENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNR 885

Query: 476  MRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ-PEWLSDFLYYAEFIFLGLFMSEM 534
             R    R+V    F   +L  + L+++ +A     Q   + +  L+Y + +F  +F  E+
Sbjct: 886  FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEI 945

Query: 535  FIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRI 590
             +KM   G       +  + FN  D  V+  S+       I+      + +LR LR+LR 
Sbjct: 946  ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRP 1002

Query: 591  FKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQ-FNFDEGTPPT 649
             +       L+++V  +  ++++I +++ +  L   +FA +G+QLF G+ +   + +  T
Sbjct: 1003 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1062

Query: 650  -------------------------------NFDTFPAAIMTVFQILTGEDWNEVMYDGI 678
                                           +FD   AA+M +F + T E W E++Y  I
Sbjct: 1063 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1122

Query: 679  KSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEA 733
             S    +G +       SI+FI+  +   + ++N+F+   +        +T  EQ E+E 
Sbjct: 1123 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEY 1174

Query: 734  ANQKL 738
             N +L
Sbjct: 1175 KNCEL 1179



 Score =  114 bits (286), Expect = 8e-25
 Identities = 77/294 (26%), Positives = 138/294 (46%), Gaps = 42/294 (14%)

Query: 472  KERRMRFYIRR---------MVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 522
            K R +R YI +         +V +  F + +  L+ LNT+C+A+ HY Q       +   
Sbjct: 1192 KARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNIL 1251

Query: 523  EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKP--------- 573
              +F GLF  EM +K+     + YF   +N FD  ++IGSI +VI +   P         
Sbjct: 1252 NMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPS 1311

Query: 574  -----GTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
                  +   I+  R  R++R+ K+      +R L+ + + S +++  +  L+ +   ++
Sbjct: 1312 MNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIY 1371

Query: 629  ALLGMQLFG--GQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMY----------- 675
            A++GMQ+FG     +  E     NF TFP A++ +F+  TGE W ++M            
Sbjct: 1372 AVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPE 1431

Query: 676  --DGIKSQGGVQGGMVFSI-YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
                  ++G    G  F++ YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1432 SEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1482



 Score =  114 bits (285), Expect = 1e-24
 Identities = 96/331 (29%), Positives = 162/331 (48%), Gaps = 33/331 (9%)

Query: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
            + F+FS +N  R    +I     F  +IL  I+ + I LA E   P    +  +  L   
Sbjct: 876  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 933

Query: 137  EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV   ++ + G +      ++
Sbjct: 934  DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLI-SFGIQSSAINVVK 992

Query: 193  TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      +FA IG++ + GK 
Sbjct: 993  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1052

Query: 253  HTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----WEGPNNGITQFDNILFA 307
            +T        D   ++ A C  +    T  +G    P      WE   N    FDN+L A
Sbjct: 1053 YT------CSDSSKQTEAEC--KGNYITYKDGEVDHPIIQPRSWE---NSKFDFDNVLAA 1101

Query: 308  VLTVFQCITMEGWTDLLYNSNDA----SGNTWNW-----LYFIPLIIIGSFFMLNLVLGV 358
            ++ +F   T EGW +LLY S D+     G  +N+     ++FI  III +FFM+N+ +G 
Sbjct: 1102 MMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGF 1161

Query: 359  LSGEFAKERERVENRRAFLKLRRQQQIEREL 389
            +   F ++ E+ E +   L   ++Q +E  L
Sbjct: 1162 VIVTFQEQGEQ-EYKNCELDKNQRQCVEYAL 1191



 Score = 84.0 bits (206), Expect = 2e-15
 Identities = 73/297 (24%), Positives = 132/297 (44%), Gaps = 65/297 (21%)

Query: 1567 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1623
            PFE  I+  I  N + L +        S A  + L     +F  +F++E  LKV+A+G+L
Sbjct: 125  PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1624 ----NYFRDAWNIFDFVTVLGSITDILVTEF----GNNFI-------NLSFLRLFRAARL 1668
                 Y R+ WN+ DF+ V+  +   ++ +     G N +       ++  LR FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1669 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF---------GNIGI 1719
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F            GI
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1720 DVEDEDS----------------------DEDEFQITEHNNFRTFFQALMLLFRSATGEA 1757
              ED+ S                      D  +  IT   NF  F  A++ +F+  T E 
Sbjct: 305  AAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGIT---NFDNFAFAMLTVFQCITMEG 361

Query: 1758 WHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
            W +++               +    G ++ + YFV+ I + SF +LNL + V+   F
Sbjct: 362  WTDVLY-------------WVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 405



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 70/302 (23%), Positives = 120/302 (39%), Gaps = 81/302 (26%)

Query: 100  FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
            FEY++   I+ N I LA++ +            ++     F G+F  E  +K+IA    F
Sbjct: 1218 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1270

Query: 160  HKGSYLRNGWNVMDFVVVLTGILATVGTE--------------------FDLRTLRAVRV 199
                Y  + WNV DF++V+  I+  + +E                      +   R  RV
Sbjct: 1271 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRV 1330

Query: 200  LRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEE 259
            +R +KL+S    ++ +L + +K+   L  + LL+     I+A+IG++ + GK        
Sbjct: 1331 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI------- 1382

Query: 260  GTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEG 319
                      A   T E  R               NN    F     AVL +F+C T E 
Sbjct: 1383 ----------ALNDTTEINR---------------NNNFQTFPQ---AVLLLFRCATGEA 1414

Query: 320  WTDLLY---------------NSNDAS---GNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
            W D++                NS +     G+++   YFI   ++ +F ++NL + V+  
Sbjct: 1415 WQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMD 1474

Query: 362  EF 363
             F
Sbjct: 1475 NF 1476


>gi|193788540 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 16 [Homo sapiens]
          Length = 2138

 Score =  777 bits (2006), Expect = 0.0
 Identities = 406/869 (46%), Positives = 565/869 (65%), Gaps = 56/869 (6%)

Query: 1146 IVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEE 1205
            +V  P+  ++   K   K      + PPA    +N   +Q N+N +  P P  E   +E+
Sbjct: 790  LVEKPAVGESKEEKIELKSITADGESPPATK--INMDDLQPNENEDKSPYPNPETTGEED 847

Query: 1206 EEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLCHYILNLRYFEMCIL 1251
            EE+     GP+P              MP  S+ FI S+ N  R  CH I+N   F   IL
Sbjct: 848  EEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLIL 907

Query: 1252 MVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRD 1311
              I +SSI+LAAEDPVQ  + RN++L YFD VFT +FT E+ +KM   G  LH+G++ R+
Sbjct: 908  FFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRN 967

Query: 1312 LWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVV 1371
             +NILD +VVS +L++F    ++    IN +K LRVLRVLRPL+ I R   LK V  CV 
Sbjct: 968  YFNILDLLVVSVSLISFGIQSSA----INVVKILRVLRVLRPLRAINRAKGLKHVVQCVF 1023

Query: 1372 NSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK- 1430
             +++ + NI+IV  L  F+FA + VQLFKGK + C+D SK+ E +C+G Y+ Y+  EV  
Sbjct: 1024 VAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDH 1083

Query: 1431 --ARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMS 1488
               + R W+  +F +DNVL A++ LFTVST EGWP++L  S+D+  E++GP   YR+E+S
Sbjct: 1084 PIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEIS 1143

Query: 1489 IFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHM 1548
            IF+++Y ++  FF +NIFV  +I+TFQEQG++  +   L+KN+R C+++A+ A+PL R++
Sbjct: 1144 IFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYI 1203

Query: 1549 PQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSL 1608
            P+N+   QY++W  V S  FEY +  +I LNTI L M+ YG S  ++ A+ + N++FT L
Sbjct: 1204 PKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGL 1261

Query: 1609 FSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFG---------------NN 1653
            F++E +LK++AF    YF D WN+FDF+ V+GSI D++++E                 N+
Sbjct: 1262 FTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENS 1321

Query: 1654 FINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQV 1713
             I+++F RLFR  RL+KLL +G  IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQV
Sbjct: 1322 RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV 1381

Query: 1714 FGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPC-- 1771
            FG I ++        D  +I  +NNF+TF QA++LLFR ATGEAW +IML+C+ GK C  
Sbjct: 1382 FGKIALN--------DTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAP 1433

Query: 1772 ---DKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHH 1828
                 NS      CG+ FA FYF+SF  LC+FL++NLFVAVIMDNF+YLTRD SILGPHH
Sbjct: 1434 ESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHH 1493

Query: 1829 LDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADD 1888
            LDE+ R+WAEYDP A GRI + D+ +LLR I PPLG GK CPHRVACKRL+ M++P+  D
Sbjct: 1494 LDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSD 1553

Query: 1889 NTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKS 1948
             TV FN+TL AL+RTAL IK      + +Q + ELR  +  IW   S K LD +V P   
Sbjct: 1554 GTVMFNATLFALVRTALRIKTE---GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGD 1610

Query: 1949 TDLTVGKIYAAMMIMEYYRQSKAKKLQAM 1977
             ++TVGK YA  +I EY+R+ K +K Q +
Sbjct: 1611 DEVTVGKFYATFLIQEYFRKFKKRKEQGL 1639



 Score =  671 bits (1730), Expect = 0.0
 Identities = 383/827 (46%), Positives = 507/827 (61%), Gaps = 64/827 (7%)

Query: 2   ARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQG-----------GQPGAQRMYKQ 50
           + +G   PA +    + AAAG+        GA  S Q            G  G   +   
Sbjct: 18  SNYGSPRPA-HANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTV 76

Query: 51  SMAQRARTMALYNPIPVRQNCLTVNR---SLFLFSEDNVVRKYAKKITEWPPFEYMILAT 107
           S  QR R    Y   P +Q   T  R   +L   +  N +R+    I EW PFE +IL T
Sbjct: 77  SSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLT 133

Query: 108 IIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRN 167
           I ANC+ LA+    P+DD    +  L+  E  F+ IF  EA +K+IA G  FH  +YLRN
Sbjct: 134 IFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRN 193

Query: 168 GWNVMDFVVVLTGILATV----------------GTEFDLRTLRAVRVLRPLKLVSGIPS 211
           GWN++DF++V+ G+ + +                G  FD++ LRA RVLRPL+LVSG+PS
Sbjct: 194 GWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPS 253

Query: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF-EEGTDDIQGES-P 269
           LQVVL SI+KAM+PLL I LL+ F I+I+AIIGLE +MGK H TC+ +EG  D+  E  P
Sbjct: 254 LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 270 APCGTEEP-ARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSN 328
           +PC  E    R C NGT C+P W+GP +GIT FDN  FA+LTVFQCITMEGWTD+LY  N
Sbjct: 314 SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 329 DASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 388
           DA G  W W+YF+ LIIIGSFF+LNLVLGVLSGEF+KERE+ + R  F KLR +QQ+E +
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433

Query: 389 LNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIAS 448
           L GY++WI++AE++    ++   ++  P     R  ++  S+T+ +N E       +  +
Sbjct: 434 LKGYLDWITQAEDIDPENEDEGMDEEKP-----RNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 449 VGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH 508
            G   AR + + +K + S ++ +  R  R   R  VK+  FYW V+ LV LNTL +A  H
Sbjct: 489 CG---ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEH 545

Query: 509 YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIW 568
           YNQP WL++    A    L LF +EM +KMY LG + YF S FN FDC V+ G I E I 
Sbjct: 546 YNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETIL 605

Query: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
              K  +  GISVLR +RLLRIFK+T+YW SL NLV SLLNS++SI SLL LLFLFI++F
Sbjct: 606 VETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIF 665

Query: 629 ALLGMQLFGGQFNFDE-GTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQ-G 686
           +LLGMQLFGG+FNFDE  T  + FD FP +++TVFQILTGEDWN VMYDGI + GG    
Sbjct: 666 SLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 687 GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEV 746
           GM+  IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EEEE   +K         
Sbjct: 726 GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERK--------- 776

Query: 747 AEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREA 793
                   A  +   K+Q+  +KPA  V E +  ++  +++ A  E+
Sbjct: 777 ------KLARTASPEKKQELVEKPA--VGESKEEKIELKSITADGES 815



 Score =  202 bits (513), Expect = 4e-51
 Identities = 176/705 (24%), Positives = 317/705 (44%), Gaps = 120/705 (17%)

Query: 1200 EEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSI 1259
            + K+++    + +       P  ++  L+  NP+RR C  I+  + FE+ IL+ I  + +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1260 ALAAEDPV---QPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNIL 1316
            ALA   P      NA  +N+ R  +Y+F  +FT E  +K+I  GL+ H  AY R+ WN+L
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV-EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198

Query: 1317 DFIVVSGALVAFAFTGNSKGKDINT---------IKSLRVLRVLRPLKTIKRLPKLKAVF 1367
            DFI+V   L +      +K    N          +K+LR  RVLRPL+ +  +P L+ V 
Sbjct: 199  DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258

Query: 1368 DCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC---------- 1417
            + ++ ++  + +I ++ +  + I+A++ ++LF GK  H T  ++E   D           
Sbjct: 259  NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK-MHKTCYNQEGIADVPAEDDPSPCA 317

Query: 1418 --RGKYLLYEKNEVKARDREWKKYEF-HYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
               G     +   V     +  K+   ++DN  +A+LT+F   T EGW  VL    DA  
Sbjct: 318  LETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAV- 376

Query: 1475 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KMMEEY 1525
                     R    I++V   ++  FF +N+ + ++   F ++       GD  K+ E+ 
Sbjct: 377  --------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428

Query: 1526 SLEKNERACIDFAISA---------------KPLTRHMP--------------------- 1549
             LE++ +  +D+   A               KP    MP                     
Sbjct: 429  QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 1550 ----------QNKQSFQYRMWQ---------FVVSPPFEYTIMAMIALNTIVLMMKFYGA 1590
                      ++K S  +R W           V S  F + ++ ++ LNT+ +  + Y  
Sbjct: 489  CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548

Query: 1591 SVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITD-ILVTE 1649
                       N    +LF+ E +LK+ + G+  YF   +N FD   V G I + ILV  
Sbjct: 549  PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 1650 FGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAII 1709
               + + +S LR  R  R+ K+ R   ++  L+ + + S +++  + LL+ +   I++++
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 1710 GMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGK 1769
            GMQ+FG           + DE Q T  + F  F Q+L+ +F+  TGE W+++M   +   
Sbjct: 669  GMQLFGG--------KFNFDEMQ-TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAY 719

Query: 1770 PCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
                  G+L           YF+  +F+C ++++LN+F+A+ +DN
Sbjct: 720  GGPSFPGML--------VCIYFI-ILFICGNYILLNVFLAIAVDN 755



 Score =  144 bits (362), Expect = 1e-33
 Identities = 179/785 (22%), Positives = 325/785 (41%), Gaps = 161/785 (20%)

Query: 33   AGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAK 92
            AGG  +G   GA+  ++ S ++ +R    +N    R+ C    +S       NV      
Sbjct: 480  AGGDIEGENCGARLAHRISKSKFSRYWRRWNRF-CRRKCRAAVKS-------NV------ 525

Query: 93   KITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKI 152
                   F ++++  +  N + +A E +   +    ++E  D      + +F  E  +K+
Sbjct: 526  -------FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKM 575

Query: 153  IALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------FDLRTLRAVRVLRPLKLV 206
             +LG      +Y  + +N  D  VV  GIL T+  E        +  LR VR+LR  K+ 
Sbjct: 576  YSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKIT 631

Query: 207  SGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQG 266
                SL  ++ S++ ++  +  + LLLF  I+IF+++G++ + GKF+        D++Q 
Sbjct: 632  RYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF-------DEMQT 684

Query: 267  ESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYN 326
                                            + FDN   ++LTVFQ +T E W  ++Y+
Sbjct: 685  RR------------------------------STFDNFPQSLLTVFQILTGEDWNSVMYD 714

Query: 327  SNDASGNT-----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERE 368
               A G          +YFI L I G++ +LN+ L +     A             +E+E
Sbjct: 715  GIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKE 774

Query: 369  RVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIK- 427
            R +  R     ++Q+ +E+   G     SK E++ L     DGE   P    +    ++ 
Sbjct: 775  RKKLARTASPEKKQELVEKPAVGE----SKEEKIELKSITADGES--PPATKINMDDLQP 828

Query: 428  ---KSKTDLLNPEEA--EDQLADIASVGS---PFARASIKSAKL---ENSTFF-HKKERR 475
               + K+   NPE    ED+      VG    P +   +K   +   E S FF      R
Sbjct: 829  NENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNR 888

Query: 476  MRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ-PEWLSDFLYYAEFIFLGLFMSEM 534
             R    R+V    F   +L  + L+++ +A     Q   + +  L+Y + +F  +F  E+
Sbjct: 889  FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEI 948

Query: 535  FIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRI 590
             +KM   G       +  + FN  D  V+  S+       I+      + +LR LR+LR 
Sbjct: 949  ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRP 1005

Query: 591  FKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQ-FNFDEGTPPT 649
             +       L+++V  +  ++++I +++ +  L   +FA +G+QLF G+ +   + +  T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 650  -------------------------------NFDTFPAAIMTVFQILTGEDWNEVMYDGI 678
                                           +FD   AA+M +F + T E W E++Y  I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 679  KSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEA 733
             S    +G +       SI+FI+  +   + ++N+F+   +        +T  EQ E+E 
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEY 1177

Query: 734  ANQKL 738
             N +L
Sbjct: 1178 KNCEL 1182



 Score =  114 bits (286), Expect = 8e-25
 Identities = 77/294 (26%), Positives = 138/294 (46%), Gaps = 42/294 (14%)

Query: 472  KERRMRFYIRR---------MVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 522
            K R +R YI +         +V +  F + +  L+ LNT+C+A+ HY Q       +   
Sbjct: 1195 KARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNIL 1254

Query: 523  EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKP--------- 573
              +F GLF  EM +K+     + YF   +N FD  ++IGSI +VI +   P         
Sbjct: 1255 NMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPS 1314

Query: 574  -----GTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
                  +   I+  R  R++R+ K+      +R L+ + + S +++  +  L+ +   ++
Sbjct: 1315 MNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIY 1374

Query: 629  ALLGMQLFG--GQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMY----------- 675
            A++GMQ+FG     +  E     NF TFP A++ +F+  TGE W ++M            
Sbjct: 1375 AVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPE 1434

Query: 676  --DGIKSQGGVQGGMVFSI-YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
                  ++G    G  F++ YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1435 SEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485



 Score =  114 bits (285), Expect = 1e-24
 Identities = 96/331 (29%), Positives = 162/331 (48%), Gaps = 33/331 (9%)

Query: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
            + F+FS +N  R    +I     F  +IL  I+ + I LA E   P    +  +  L   
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 936

Query: 137  EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV   ++ + G +      ++
Sbjct: 937  DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLI-SFGIQSSAINVVK 995

Query: 193  TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      +FA IG++ + GK 
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 253  HTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----WEGPNNGITQFDNILFA 307
            +T        D   ++ A C  +    T  +G    P      WE   N    FDN+L A
Sbjct: 1056 YT------CSDSSKQTEAEC--KGNYITYKDGEVDHPIIQPRSWE---NSKFDFDNVLAA 1104

Query: 308  VLTVFQCITMEGWTDLLYNSNDA----SGNTWNW-----LYFIPLIIIGSFFMLNLVLGV 358
            ++ +F   T EGW +LLY S D+     G  +N+     ++FI  III +FFM+N+ +G 
Sbjct: 1105 MMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGF 1164

Query: 359  LSGEFAKERERVENRRAFLKLRRQQQIEREL 389
            +   F ++ E+ E +   L   ++Q +E  L
Sbjct: 1165 VIVTFQEQGEQ-EYKNCELDKNQRQCVEYAL 1194



 Score = 82.0 bits (201), Expect = 6e-15
 Identities = 73/297 (24%), Positives = 130/297 (43%), Gaps = 62/297 (20%)

Query: 1567 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1623
            PFE  I+  I  N + L +        S A  + L     +F  +F++E  LKV+A+G+L
Sbjct: 125  PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1624 ----NYFRDAWNIFDFVTVLGSITDILVTEF----GNNFI-------NLSFLRLFRAARL 1668
                 Y R+ WN+ DF+ V+  +   ++ +     G N +       ++  LR FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1669 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF---------GNIGI 1719
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F            GI
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1720 -DVEDEDSDEDEFQITEH---------------------NNFRTFFQALMLLFRSATGEA 1757
             DV  ED        T H                      NF  F  A++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1758 WHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
            W +++               +    G ++ + YFV+ I + SF +LNL + V+   F
Sbjct: 365  WTDVLY-------------WVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 70/302 (23%), Positives = 120/302 (39%), Gaps = 81/302 (26%)

Query: 100  FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
            FEY++   I+ N I LA++ +            ++     F G+F  E  +K+IA    F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273

Query: 160  HKGSYLRNGWNVMDFVVVLTGILATVGTE--------------------FDLRTLRAVRV 199
                Y  + WNV DF++V+  I+  + +E                      +   R  RV
Sbjct: 1274 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333

Query: 200  LRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEE 259
            +R +KL+S    ++ +L + +K+   L  + LL+     I+A+IG++ + GK        
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI------- 1385

Query: 260  GTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEG 319
                      A   T E  R               NN    F     AVL +F+C T E 
Sbjct: 1386 ----------ALNDTTEINR---------------NNNFQTFPQ---AVLLLFRCATGEA 1417

Query: 320  WTDLLY---------------NSNDAS---GNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
            W D++                NS +     G+++   YFI   ++ +F ++NL + V+  
Sbjct: 1418 WQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMD 1477

Query: 362  EF 363
             F
Sbjct: 1478 NF 1479


>gi|193788534 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 12 [Homo sapiens]
          Length = 2146

 Score =  777 bits (2006), Expect = 0.0
 Identities = 410/874 (46%), Positives = 568/874 (64%), Gaps = 58/874 (6%)

Query: 1146 IVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEE 1205
            +V  P+  ++   K   K      + PPA    +N   +Q N+N +  P P  E   +E+
Sbjct: 790  LVEKPAVGESKEEKIELKSITADGESPPATK--INMDDLQPNENEDKSPYPNPETTGEED 847

Query: 1206 EEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLCHYILNLRYFEMCIL 1251
            EE+     GP+P              MP  S+ FI S+ N  R  CH I+N   F   IL
Sbjct: 848  EEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLIL 907

Query: 1252 MVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRD 1311
              I +SSI+LAAEDPVQ  + RN++L   DYVFT +FT E+++KM   G  LH+G++ R+
Sbjct: 908  FFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRN 967

Query: 1312 LWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVV 1371
             +NILD +VVS +L++F    ++    IN +K LRVLRVLRPL+ I R   LK V  CV 
Sbjct: 968  YFNILDLLVVSVSLISFGIQSSA----INVVKILRVLRVLRPLRAINRAKGLKHVVQCVF 1023

Query: 1372 NSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK- 1430
             +++ + NI+IV  L  F+FA + VQLFKGK + C+D SK+ E +C+G Y+ Y+  EV  
Sbjct: 1024 VAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDH 1083

Query: 1431 --ARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMS 1488
               + R W+  +F +DNVL A++ LFTVST EGWP++L  S+D+  E++GP   YR+E+S
Sbjct: 1084 PIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEIS 1143

Query: 1489 IFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHM 1548
            IF+++Y ++  FF +NIFV  +I+TFQEQG++  +   L+KN+R C+++A+ A+PL R++
Sbjct: 1144 IFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYI 1203

Query: 1549 PQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSL 1608
            P+N+   QY++W  V S  FEY +  +I LNTI L M+ YG S  ++ A+ + N++FT L
Sbjct: 1204 PKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGL 1261

Query: 1609 FSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGN----NFINLSFLRLFR 1664
            F++E +LK++AF   +YF DAWN FD + V+GSI DI +TE  N    + I+++F RLFR
Sbjct: 1262 FTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFR 1321

Query: 1665 AARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDE 1724
              RL+KLL +G  IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQVFG I ++    
Sbjct: 1322 VMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALN---- 1377

Query: 1725 DSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPC-----DKNSGILT 1779
                D  +I  +NNF+TF QA++LLFR ATGEAW +IML+C+ GK C       NS    
Sbjct: 1378 ----DTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGE 1433

Query: 1780 RECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEY 1839
              CG+ FA FYF+SF  LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDE+ R+WAEY
Sbjct: 1434 TPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEY 1493

Query: 1840 DPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMA 1899
            DP A GRI + D+ +LLR I PPLG GK CPHRVACKRL+ M++P+  D TV FN+TL A
Sbjct: 1494 DPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFA 1553

Query: 1900 LIRTALDIKIAKG--------GADK--------QQMDAELRKEMMAIWPNLSQKTLDLLV 1943
            L+RTAL IK  +G        GA+         +Q + ELR  +  IW   S K LD +V
Sbjct: 1554 LVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVV 1613

Query: 1944 TPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAM 1977
             P    ++TVGK YA  +I EY+R+ K +K Q +
Sbjct: 1614 PPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGL 1647



 Score =  671 bits (1730), Expect = 0.0
 Identities = 383/827 (46%), Positives = 507/827 (61%), Gaps = 64/827 (7%)

Query: 2   ARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQG-----------GQPGAQRMYKQ 50
           + +G   PA +    + AAAG+        GA  S Q            G  G   +   
Sbjct: 18  SNYGSPRPA-HANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTV 76

Query: 51  SMAQRARTMALYNPIPVRQNCLTVNR---SLFLFSEDNVVRKYAKKITEWPPFEYMILAT 107
           S  QR R    Y   P +Q   T  R   +L   +  N +R+    I EW PFE +IL T
Sbjct: 77  SSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLT 133

Query: 108 IIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRN 167
           I ANC+ LA+    P+DD    +  L+  E  F+ IF  EA +K+IA G  FH  +YLRN
Sbjct: 134 IFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRN 193

Query: 168 GWNVMDFVVVLTGILATV----------------GTEFDLRTLRAVRVLRPLKLVSGIPS 211
           GWN++DF++V+ G+ + +                G  FD++ LRA RVLRPL+LVSG+PS
Sbjct: 194 GWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPS 253

Query: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF-EEGTDDIQGES-P 269
           LQVVL SI+KAM+PLL I LL+ F I+I+AIIGLE +MGK H TC+ +EG  D+  E  P
Sbjct: 254 LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 270 APCGTEEP-ARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSN 328
           +PC  E    R C NGT C+P W+GP +GIT FDN  FA+LTVFQCITMEGWTD+LY  N
Sbjct: 314 SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 329 DASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 388
           DA G  W W+YF+ LIIIGSFF+LNLVLGVLSGEF+KERE+ + R  F KLR +QQ+E +
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433

Query: 389 LNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIAS 448
           L GY++WI++AE++    ++   ++  P     R  ++  S+T+ +N E       +  +
Sbjct: 434 LKGYLDWITQAEDIDPENEDEGMDEEKP-----RNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 449 VGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH 508
            G   AR + + +K + S ++ +  R  R   R  VK+  FYW V+ LV LNTL +A  H
Sbjct: 489 CG---ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEH 545

Query: 509 YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIW 568
           YNQP WL++    A    L LF +EM +KMY LG + YF S FN FDC V+ G I E I 
Sbjct: 546 YNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETIL 605

Query: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
              K  +  GISVLR +RLLRIFK+T+YW SL NLV SLLNS++SI SLL LLFLFI++F
Sbjct: 606 VETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIF 665

Query: 629 ALLGMQLFGGQFNFDE-GTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQ-G 686
           +LLGMQLFGG+FNFDE  T  + FD FP +++TVFQILTGEDWN VMYDGI + GG    
Sbjct: 666 SLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 687 GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEV 746
           GM+  IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EEEE   +K         
Sbjct: 726 GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERK--------- 776

Query: 747 AEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREA 793
                   A  +   K+Q+  +KPA  V E +  ++  +++ A  E+
Sbjct: 777 ------KLARTASPEKKQELVEKPA--VGESKEEKIELKSITADGES 815



 Score =  202 bits (513), Expect = 4e-51
 Identities = 176/705 (24%), Positives = 317/705 (44%), Gaps = 120/705 (17%)

Query: 1200 EEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSI 1259
            + K+++    + +       P  ++  L+  NP+RR C  I+  + FE+ IL+ I  + +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1260 ALAAEDPV---QPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNIL 1316
            ALA   P      NA  +N+ R  +Y+F  +FT E  +K+I  GL+ H  AY R+ WN+L
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV-EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198

Query: 1317 DFIVVSGALVAFAFTGNSKGKDINT---------IKSLRVLRVLRPLKTIKRLPKLKAVF 1367
            DFI+V   L +      +K    N          +K+LR  RVLRPL+ +  +P L+ V 
Sbjct: 199  DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258

Query: 1368 DCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC---------- 1417
            + ++ ++  + +I ++ +  + I+A++ ++LF GK  H T  ++E   D           
Sbjct: 259  NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK-MHKTCYNQEGIADVPAEDDPSPCA 317

Query: 1418 --RGKYLLYEKNEVKARDREWKKYEF-HYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
               G     +   V     +  K+   ++DN  +A+LT+F   T EGW  VL    DA  
Sbjct: 318  LETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAV- 376

Query: 1475 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KMMEEY 1525
                     R    I++V   ++  FF +N+ + ++   F ++       GD  K+ E+ 
Sbjct: 377  --------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428

Query: 1526 SLEKNERACIDFAISA---------------KPLTRHMP--------------------- 1549
             LE++ +  +D+   A               KP    MP                     
Sbjct: 429  QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 1550 ----------QNKQSFQYRMWQ---------FVVSPPFEYTIMAMIALNTIVLMMKFYGA 1590
                      ++K S  +R W           V S  F + ++ ++ LNT+ +  + Y  
Sbjct: 489  CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548

Query: 1591 SVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITD-ILVTE 1649
                       N    +LF+ E +LK+ + G+  YF   +N FD   V G I + ILV  
Sbjct: 549  PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 1650 FGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAII 1709
               + + +S LR  R  R+ K+ R   ++  L+ + + S +++  + LL+ +   I++++
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 1710 GMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGK 1769
            GMQ+FG           + DE Q T  + F  F Q+L+ +F+  TGE W+++M   +   
Sbjct: 669  GMQLFGG--------KFNFDEMQ-TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAY 719

Query: 1770 PCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
                  G+L           YF+  +F+C ++++LN+F+A+ +DN
Sbjct: 720  GGPSFPGML--------VCIYFI-ILFICGNYILLNVFLAIAVDN 755



 Score =  143 bits (360), Expect = 2e-33
 Identities = 179/785 (22%), Positives = 325/785 (41%), Gaps = 161/785 (20%)

Query: 33   AGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAK 92
            AGG  +G   GA+  ++ S ++ +R    +N    R+ C    +S       NV      
Sbjct: 480  AGGDIEGENCGARLAHRISKSKFSRYWRRWNRF-CRRKCRAAVKS-------NV------ 525

Query: 93   KITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKI 152
                   F ++++  +  N + +A E +   +    ++E  D      + +F  E  +K+
Sbjct: 526  -------FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKM 575

Query: 153  IALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------FDLRTLRAVRVLRPLKLV 206
             +LG      +Y  + +N  D  VV  GIL T+  E        +  LR VR+LR  K+ 
Sbjct: 576  YSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKIT 631

Query: 207  SGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQG 266
                SL  ++ S++ ++  +  + LLLF  I+IF+++G++ + GKF+        D++Q 
Sbjct: 632  RYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF-------DEMQT 684

Query: 267  ESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYN 326
                                            + FDN   ++LTVFQ +T E W  ++Y+
Sbjct: 685  RR------------------------------STFDNFPQSLLTVFQILTGEDWNSVMYD 714

Query: 327  SNDASGNT-----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERE 368
               A G          +YFI L I G++ +LN+ L +     A             +E+E
Sbjct: 715  GIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKE 774

Query: 369  RVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIK- 427
            R +  R     ++Q+ +E+   G     SK E++ L     DGE   P    +    ++ 
Sbjct: 775  RKKLARTASPEKKQELVEKPAVGE----SKEEKIELKSITADGES--PPATKINMDDLQP 828

Query: 428  ---KSKTDLLNPEEA--EDQLADIASVGS---PFARASIKSAKL---ENSTFF-HKKERR 475
               + K+   NPE    ED+      VG    P +   +K   +   E S FF      R
Sbjct: 829  NENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNR 888

Query: 476  MRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ-PEWLSDFLYYAEFIFLGLFMSEM 534
             R    R+V    F   +L  + L+++ +A     Q   + +  L  A+++F  +F  E+
Sbjct: 889  FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEI 948

Query: 535  FIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRI 590
             +KM   G       +  + FN  D  V+  S+       I+      + +LR LR+LR 
Sbjct: 949  ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRP 1005

Query: 591  FKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQ-FNFDEGTPPT 649
             +       L+++V  +  ++++I +++ +  L   +FA +G+QLF G+ +   + +  T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 650  -------------------------------NFDTFPAAIMTVFQILTGEDWNEVMYDGI 678
                                           +FD   AA+M +F + T E W E++Y  I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 679  KSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEA 733
             S    +G +       SI+FI+  +   + ++N+F+   +        +T  EQ E+E 
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEY 1177

Query: 734  ANQKL 738
             N +L
Sbjct: 1178 KNCEL 1182



 Score =  116 bits (291), Expect = 2e-25
 Identities = 96/331 (29%), Positives = 163/331 (49%), Gaps = 33/331 (9%)

Query: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
            + F+FS +N  R    +I     F  +IL  I+ + I LA E   P    +  +  L + 
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILGNA 936

Query: 137  EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV   ++ + G +      ++
Sbjct: 937  DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLI-SFGIQSSAINVVK 995

Query: 193  TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      +FA IG++ + GK 
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 253  HTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----WEGPNNGITQFDNILFA 307
            +T        D   ++ A C  +    T  +G    P      WE   N    FDN+L A
Sbjct: 1056 YT------CSDSSKQTEAEC--KGNYITYKDGEVDHPIIQPRSWE---NSKFDFDNVLAA 1104

Query: 308  VLTVFQCITMEGWTDLLYNSNDA----SGNTWNW-----LYFIPLIIIGSFFMLNLVLGV 358
            ++ +F   T EGW +LLY S D+     G  +N+     ++FI  III +FFM+N+ +G 
Sbjct: 1105 MMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGF 1164

Query: 359  LSGEFAKERERVENRRAFLKLRRQQQIEREL 389
            +   F ++ E+ E +   L   ++Q +E  L
Sbjct: 1165 VIVTFQEQGEQ-EYKNCELDKNQRQCVEYAL 1194



 Score =  114 bits (286), Expect = 8e-25
 Identities = 73/283 (25%), Positives = 138/283 (48%), Gaps = 31/283 (10%)

Query: 472  KERRMRFYIRR---------MVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 522
            K R +R YI +         +V +  F + +  L+ LNT+C+A+ HY Q       +   
Sbjct: 1195 KARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNIL 1254

Query: 523  EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVI---KPGTSFGI 579
              +F GLF  EM +K+     + YF  ++N FD  +++GSI ++    +   +  +   I
Sbjct: 1255 NMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISI 1314

Query: 580  SVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG-- 637
            +  R  R++R+ K+      +R L+ + + S +++  +  L+ +   ++A++GMQ+FG  
Sbjct: 1315 TFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKI 1374

Query: 638  GQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMY-------------DGIKSQGGV 684
               +  E     NF TFP A++ +F+  TGE W ++M                  ++G  
Sbjct: 1375 ALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGET 1434

Query: 685  QGGMVFSI-YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
              G  F++ YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1435 PCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1474



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 79/311 (25%), Positives = 143/311 (45%), Gaps = 41/311 (13%)

Query: 1234 RRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMV 1293
            RR C   +    F   ++ ++ ++++ +A+E   QPN     V    +     +FT EM+
Sbjct: 514  RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW-LTEVQDTANKALLALFTAEML 572

Query: 1294 IKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRP 1353
            +KM  LGL     AYF  L+N  D  VV G ++            +  I  LR +R+LR 
Sbjct: 573  LKMYSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLG-ISVLRCVRLLRI 627

Query: 1354 LKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEF 1413
             K  +    L  +   ++NS++++ ++L++  LF+ IF+++ +QLF GKF          
Sbjct: 628  FKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF---------- 677

Query: 1414 EKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDAT 1473
                         +E++ R          +DN   +LLT+F + TGE W  V+    D  
Sbjct: 678  -----------NFDEMQTRRST-------FDNFPQSLLTVFQILTGEDWNSVM---YDGI 716

Query: 1474 FENQGPS-PGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNER 1532
                GPS PG  M + I++++ F+   +  +N+F+A+ +    +  + +      E+ E+
Sbjct: 717  MAYGGPSFPG--MLVCIYFIILFICGNYILLNVFLAIAVDNLAD-AESLTSAQKEEEEEK 773

Query: 1533 ACIDFAISAKP 1543
                 A +A P
Sbjct: 774  ERKKLARTASP 784



 Score = 82.0 bits (201), Expect = 6e-15
 Identities = 73/297 (24%), Positives = 130/297 (43%), Gaps = 62/297 (20%)

Query: 1567 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1623
            PFE  I+  I  N + L +        S A  + L     +F  +F++E  LKV+A+G+L
Sbjct: 125  PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1624 ----NYFRDAWNIFDFVTVLGSITDILVTEF----GNNFI-------NLSFLRLFRAARL 1668
                 Y R+ WN+ DF+ V+  +   ++ +     G N +       ++  LR FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1669 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF---------GNIGI 1719
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F            GI
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1720 -DVEDEDSDEDEFQITEH---------------------NNFRTFFQALMLLFRSATGEA 1757
             DV  ED        T H                      NF  F  A++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1758 WHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
            W +++               +    G ++ + YFV+ I + SF +LNL + V+   F
Sbjct: 365  WTDVLY-------------WVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 69/291 (23%), Positives = 118/291 (40%), Gaps = 70/291 (24%)

Query: 100  FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
            FEY++   I+ N I LA++ +            ++     F G+F  E  +K+IA    F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273

Query: 160  HKGSYLRNGWNVMDFVVVLTGILATVGTEFD---------LRTLRAVRVLRPLKLVSGIP 210
                Y  + WN  D ++V+  I+    TE +         +   R  RV+R +KL+S   
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGE 1333

Query: 211  SLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPA 270
             ++ +L + +K+   L  + LL+     I+A+IG++ + GK                  A
Sbjct: 1334 GIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI-----------------A 1375

Query: 271  PCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLY----- 325
               T E  R               NN    F     AVL +F+C T E W D++      
Sbjct: 1376 LNDTTEINR---------------NNNFQTFPQ---AVLLLFRCATGEAWQDIMLACMPG 1417

Query: 326  ----------NSNDAS---GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 363
                      NS +     G+++   YFI   ++ +F ++NL + V+   F
Sbjct: 1418 KKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1468


>gi|120433602 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 18 [Homo sapiens]
          Length = 2138

 Score =  776 bits (2003), Expect = 0.0
 Identities = 408/869 (46%), Positives = 564/869 (64%), Gaps = 56/869 (6%)

Query: 1146 IVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEE 1205
            +V  P+  ++   K   K      + PPA    +N   +Q N+N +  P P  E   +E+
Sbjct: 790  LVEKPAVGESKEEKIELKSITADGESPPATK--INMDDLQPNENEDKSPYPNPETTGEED 847

Query: 1206 EEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLCHYILNLRYFEMCIL 1251
            EE+     GP+P              MP  S+ FI S+ N  R  CH I+N   F   IL
Sbjct: 848  EEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLIL 907

Query: 1252 MVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRD 1311
              I +SSI+LAAEDPVQ  + RN++L YFD VFT +FT E+ +KM   G  LH+G++ R+
Sbjct: 908  FFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRN 967

Query: 1312 LWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVV 1371
             +NILD +VVS +L++F    ++    IN +K LRVLRVLRPL+ I R   LK V  CV 
Sbjct: 968  YFNILDLLVVSVSLISFGIQSSA----INVVKILRVLRVLRPLRAINRAKGLKHVVQCVF 1023

Query: 1372 NSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK- 1430
             +++ + NI+IV  L  F+FA + VQLFKGK + C+D SK+ E +C+G Y+ Y+  EV  
Sbjct: 1024 VAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDH 1083

Query: 1431 --ARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMS 1488
               + R W+  +F +DNVL A++ LFTVST EGWP++L  S+D+  E++GP   YR+E+S
Sbjct: 1084 PIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEIS 1143

Query: 1489 IFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHM 1548
            IF+++Y ++  FF +NIFV  +I+TFQEQG++  +   L+KN+R C+++A+ A+PL R++
Sbjct: 1144 IFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYI 1203

Query: 1549 PQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSL 1608
            P+N+   QY++W  V S  FEY +  +I LNTI L M+ YG S  ++ A+ + N++FT L
Sbjct: 1204 PKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGL 1261

Query: 1609 FSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFG---------------NN 1653
            F++E +LK++AF   +YF DAWN FD + V+GSI DI +TE                 N+
Sbjct: 1262 FTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENS 1321

Query: 1654 FINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQV 1713
             I+++F RLFR  RL+KLL +G  IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQV
Sbjct: 1322 RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV 1381

Query: 1714 FGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPC-- 1771
            FG I ++        D  +I  +NNF+TF QA++LLFR ATGEAW +IML+C+ GK C  
Sbjct: 1382 FGKIALN--------DTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAP 1433

Query: 1772 ---DKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHH 1828
                 NS      CG+ FA FYF+SF  LC+FL++NLFVAVIMDNF+YLTRD SILGPHH
Sbjct: 1434 ESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHH 1493

Query: 1829 LDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADD 1888
            LDE+ R+WAEYDP A GRI + D+ +LLR I PPLG GK CPHRVACKRL+ M++P+  D
Sbjct: 1494 LDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSD 1553

Query: 1889 NTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKS 1948
             TV FN+TL AL+RTAL IK      + +Q + ELR  +  IW   S K LD +V P   
Sbjct: 1554 GTVMFNATLFALVRTALRIKTE---GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGD 1610

Query: 1949 TDLTVGKIYAAMMIMEYYRQSKAKKLQAM 1977
             ++TVGK YA  +I EY+R+ K +K Q +
Sbjct: 1611 DEVTVGKFYATFLIQEYFRKFKKRKEQGL 1639



 Score =  671 bits (1730), Expect = 0.0
 Identities = 383/827 (46%), Positives = 507/827 (61%), Gaps = 64/827 (7%)

Query: 2   ARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQG-----------GQPGAQRMYKQ 50
           + +G   PA +    + AAAG+        GA  S Q            G  G   +   
Sbjct: 18  SNYGSPRPA-HANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTV 76

Query: 51  SMAQRARTMALYNPIPVRQNCLTVNR---SLFLFSEDNVVRKYAKKITEWPPFEYMILAT 107
           S  QR R    Y   P +Q   T  R   +L   +  N +R+    I EW PFE +IL T
Sbjct: 77  SSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLT 133

Query: 108 IIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRN 167
           I ANC+ LA+    P+DD    +  L+  E  F+ IF  EA +K+IA G  FH  +YLRN
Sbjct: 134 IFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRN 193

Query: 168 GWNVMDFVVVLTGILATV----------------GTEFDLRTLRAVRVLRPLKLVSGIPS 211
           GWN++DF++V+ G+ + +                G  FD++ LRA RVLRPL+LVSG+PS
Sbjct: 194 GWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPS 253

Query: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF-EEGTDDIQGES-P 269
           LQVVL SI+KAM+PLL I LL+ F I+I+AIIGLE +MGK H TC+ +EG  D+  E  P
Sbjct: 254 LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 270 APCGTEEP-ARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSN 328
           +PC  E    R C NGT C+P W+GP +GIT FDN  FA+LTVFQCITMEGWTD+LY  N
Sbjct: 314 SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 329 DASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 388
           DA G  W W+YF+ LIIIGSFF+LNLVLGVLSGEF+KERE+ + R  F KLR +QQ+E +
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433

Query: 389 LNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIAS 448
           L GY++WI++AE++    ++   ++  P     R  ++  S+T+ +N E       +  +
Sbjct: 434 LKGYLDWITQAEDIDPENEDEGMDEEKP-----RNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 449 VGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH 508
            G   AR + + +K + S ++ +  R  R   R  VK+  FYW V+ LV LNTL +A  H
Sbjct: 489 CG---ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEH 545

Query: 509 YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIW 568
           YNQP WL++    A    L LF +EM +KMY LG + YF S FN FDC V+ G I E I 
Sbjct: 546 YNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETIL 605

Query: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
              K  +  GISVLR +RLLRIFK+T+YW SL NLV SLLNS++SI SLL LLFLFI++F
Sbjct: 606 VETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIF 665

Query: 629 ALLGMQLFGGQFNFDE-GTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQ-G 686
           +LLGMQLFGG+FNFDE  T  + FD FP +++TVFQILTGEDWN VMYDGI + GG    
Sbjct: 666 SLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 687 GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEV 746
           GM+  IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EEEE   +K         
Sbjct: 726 GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERK--------- 776

Query: 747 AEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREA 793
                   A  +   K+Q+  +KPA  V E +  ++  +++ A  E+
Sbjct: 777 ------KLARTASPEKKQELVEKPA--VGESKEEKIELKSITADGES 815



 Score =  202 bits (513), Expect = 4e-51
 Identities = 176/705 (24%), Positives = 317/705 (44%), Gaps = 120/705 (17%)

Query: 1200 EEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSI 1259
            + K+++    + +       P  ++  L+  NP+RR C  I+  + FE+ IL+ I  + +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1260 ALAAEDPV---QPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNIL 1316
            ALA   P      NA  +N+ R  +Y+F  +FT E  +K+I  GL+ H  AY R+ WN+L
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV-EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198

Query: 1317 DFIVVSGALVAFAFTGNSKGKDINT---------IKSLRVLRVLRPLKTIKRLPKLKAVF 1367
            DFI+V   L +      +K    N          +K+LR  RVLRPL+ +  +P L+ V 
Sbjct: 199  DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258

Query: 1368 DCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC---------- 1417
            + ++ ++  + +I ++ +  + I+A++ ++LF GK  H T  ++E   D           
Sbjct: 259  NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK-MHKTCYNQEGIADVPAEDDPSPCA 317

Query: 1418 --RGKYLLYEKNEVKARDREWKKYEF-HYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
               G     +   V     +  K+   ++DN  +A+LT+F   T EGW  VL    DA  
Sbjct: 318  LETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAV- 376

Query: 1475 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KMMEEY 1525
                     R    I++V   ++  FF +N+ + ++   F ++       GD  K+ E+ 
Sbjct: 377  --------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428

Query: 1526 SLEKNERACIDFAISA---------------KPLTRHMP--------------------- 1549
             LE++ +  +D+   A               KP    MP                     
Sbjct: 429  QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 1550 ----------QNKQSFQYRMWQ---------FVVSPPFEYTIMAMIALNTIVLMMKFYGA 1590
                      ++K S  +R W           V S  F + ++ ++ LNT+ +  + Y  
Sbjct: 489  CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548

Query: 1591 SVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITD-ILVTE 1649
                       N    +LF+ E +LK+ + G+  YF   +N FD   V G I + ILV  
Sbjct: 549  PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 1650 FGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAII 1709
               + + +S LR  R  R+ K+ R   ++  L+ + + S +++  + LL+ +   I++++
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 1710 GMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGK 1769
            GMQ+FG           + DE Q T  + F  F Q+L+ +F+  TGE W+++M   +   
Sbjct: 669  GMQLFGG--------KFNFDEMQ-TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAY 719

Query: 1770 PCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
                  G+L           YF+  +F+C ++++LN+F+A+ +DN
Sbjct: 720  GGPSFPGML--------VCIYFI-ILFICGNYILLNVFLAIAVDN 755



 Score =  144 bits (362), Expect = 1e-33
 Identities = 179/785 (22%), Positives = 325/785 (41%), Gaps = 161/785 (20%)

Query: 33   AGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAK 92
            AGG  +G   GA+  ++ S ++ +R    +N    R+ C    +S       NV      
Sbjct: 480  AGGDIEGENCGARLAHRISKSKFSRYWRRWNRF-CRRKCRAAVKS-------NV------ 525

Query: 93   KITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKI 152
                   F ++++  +  N + +A E +   +    ++E  D      + +F  E  +K+
Sbjct: 526  -------FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKM 575

Query: 153  IALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------FDLRTLRAVRVLRPLKLV 206
             +LG      +Y  + +N  D  VV  GIL T+  E        +  LR VR+LR  K+ 
Sbjct: 576  YSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKIT 631

Query: 207  SGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQG 266
                SL  ++ S++ ++  +  + LLLF  I+IF+++G++ + GKF+        D++Q 
Sbjct: 632  RYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF-------DEMQT 684

Query: 267  ESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYN 326
                                            + FDN   ++LTVFQ +T E W  ++Y+
Sbjct: 685  RR------------------------------STFDNFPQSLLTVFQILTGEDWNSVMYD 714

Query: 327  SNDASGNT-----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERE 368
               A G          +YFI L I G++ +LN+ L +     A             +E+E
Sbjct: 715  GIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKE 774

Query: 369  RVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIK- 427
            R +  R     ++Q+ +E+   G     SK E++ L     DGE   P    +    ++ 
Sbjct: 775  RKKLARTASPEKKQELVEKPAVGE----SKEEKIELKSITADGES--PPATKINMDDLQP 828

Query: 428  ---KSKTDLLNPEEA--EDQLADIASVGS---PFARASIKSAKL---ENSTFF-HKKERR 475
               + K+   NPE    ED+      VG    P +   +K   +   E S FF      R
Sbjct: 829  NENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNR 888

Query: 476  MRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ-PEWLSDFLYYAEFIFLGLFMSEM 534
             R    R+V    F   +L  + L+++ +A     Q   + +  L+Y + +F  +F  E+
Sbjct: 889  FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEI 948

Query: 535  FIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRI 590
             +KM   G       +  + FN  D  V+  S+       I+      + +LR LR+LR 
Sbjct: 949  ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRP 1005

Query: 591  FKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQ-FNFDEGTPPT 649
             +       L+++V  +  ++++I +++ +  L   +FA +G+QLF G+ +   + +  T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 650  -------------------------------NFDTFPAAIMTVFQILTGEDWNEVMYDGI 678
                                           +FD   AA+M +F + T E W E++Y  I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 679  KSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEA 733
             S    +G +       SI+FI+  +   + ++N+F+   +        +T  EQ E+E 
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEY 1177

Query: 734  ANQKL 738
             N +L
Sbjct: 1178 KNCEL 1182



 Score =  114 bits (285), Expect = 1e-24
 Identities = 96/331 (29%), Positives = 162/331 (48%), Gaps = 33/331 (9%)

Query: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
            + F+FS +N  R    +I     F  +IL  I+ + I LA E   P    +  +  L   
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 936

Query: 137  EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV   ++ + G +      ++
Sbjct: 937  DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLI-SFGIQSSAINVVK 995

Query: 193  TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      +FA IG++ + GK 
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 253  HTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----WEGPNNGITQFDNILFA 307
            +T        D   ++ A C  +    T  +G    P      WE   N    FDN+L A
Sbjct: 1056 YT------CSDSSKQTEAEC--KGNYITYKDGEVDHPIIQPRSWE---NSKFDFDNVLAA 1104

Query: 308  VLTVFQCITMEGWTDLLYNSNDA----SGNTWNW-----LYFIPLIIIGSFFMLNLVLGV 358
            ++ +F   T EGW +LLY S D+     G  +N+     ++FI  III +FFM+N+ +G 
Sbjct: 1105 MMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGF 1164

Query: 359  LSGEFAKERERVENRRAFLKLRRQQQIEREL 389
            +   F ++ E+ E +   L   ++Q +E  L
Sbjct: 1165 VIVTFQEQGEQ-EYKNCELDKNQRQCVEYAL 1194



 Score =  113 bits (282), Expect = 2e-24
 Identities = 74/294 (25%), Positives = 138/294 (46%), Gaps = 42/294 (14%)

Query: 472  KERRMRFYIRR---------MVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 522
            K R +R YI +         +V +  F + +  L+ LNT+C+A+ HY Q       +   
Sbjct: 1195 KARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNIL 1254

Query: 523  EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKP--------- 573
              +F GLF  EM +K+     + YF  ++N FD  +++GSI ++    + P         
Sbjct: 1255 NMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPS 1314

Query: 574  -----GTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
                  +   I+  R  R++R+ K+      +R L+ + + S +++  +  L+ +   ++
Sbjct: 1315 MNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIY 1374

Query: 629  ALLGMQLFG--GQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMY----------- 675
            A++GMQ+FG     +  E     NF TFP A++ +F+  TGE W ++M            
Sbjct: 1375 AVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPE 1434

Query: 676  --DGIKSQGGVQGGMVFSI-YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
                  ++G    G  F++ YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1435 SEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 79/311 (25%), Positives = 143/311 (45%), Gaps = 41/311 (13%)

Query: 1234 RRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMV 1293
            RR C   +    F   ++ ++ ++++ +A+E   QPN     V    +     +FT EM+
Sbjct: 514  RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW-LTEVQDTANKALLALFTAEML 572

Query: 1294 IKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRP 1353
            +KM  LGL     AYF  L+N  D  VV G ++            +  I  LR +R+LR 
Sbjct: 573  LKMYSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLG-ISVLRCVRLLRI 627

Query: 1354 LKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEF 1413
             K  +    L  +   ++NS++++ ++L++  LF+ IF+++ +QLF GKF          
Sbjct: 628  FKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF---------- 677

Query: 1414 EKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDAT 1473
                         +E++ R          +DN   +LLT+F + TGE W  V+    D  
Sbjct: 678  -----------NFDEMQTRRST-------FDNFPQSLLTVFQILTGEDWNSVM---YDGI 716

Query: 1474 FENQGPS-PGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNER 1532
                GPS PG  M + I++++ F+   +  +N+F+A+ +    +  + +      E+ E+
Sbjct: 717  MAYGGPSFPG--MLVCIYFIILFICGNYILLNVFLAIAVDNLAD-AESLTSAQKEEEEEK 773

Query: 1533 ACIDFAISAKP 1543
                 A +A P
Sbjct: 774  ERKKLARTASP 784



 Score = 82.0 bits (201), Expect = 6e-15
 Identities = 73/297 (24%), Positives = 130/297 (43%), Gaps = 62/297 (20%)

Query: 1567 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1623
            PFE  I+  I  N + L +        S A  + L     +F  +F++E  LKV+A+G+L
Sbjct: 125  PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1624 ----NYFRDAWNIFDFVTVLGSITDILVTEF----GNNFI-------NLSFLRLFRAARL 1668
                 Y R+ WN+ DF+ V+  +   ++ +     G N +       ++  LR FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1669 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF---------GNIGI 1719
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F            GI
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1720 -DVEDEDSDEDEFQITEH---------------------NNFRTFFQALMLLFRSATGEA 1757
             DV  ED        T H                      NF  F  A++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1758 WHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
            W +++               +    G ++ + YFV+ I + SF +LNL + V+   F
Sbjct: 365  WTDVLY-------------WVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 69/302 (22%), Positives = 118/302 (39%), Gaps = 81/302 (26%)

Query: 100  FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
            FEY++   I+ N I LA++ +            ++     F G+F  E  +K+IA    F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273

Query: 160  HKGSYLRNGWNVMDFVVVLTGILATVGTEFD--------------------LRTLRAVRV 199
                Y  + WN  D ++V+  I+    TE +                    +   R  RV
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333

Query: 200  LRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEE 259
            +R +KL+S    ++ +L + +K+   L  + LL+     I+A+IG++ + GK        
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI------- 1385

Query: 260  GTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEG 319
                      A   T E  R               NN    F     AVL +F+C T E 
Sbjct: 1386 ----------ALNDTTEINR---------------NNNFQTFPQ---AVLLLFRCATGEA 1417

Query: 320  WTDLLY---------------NSNDAS---GNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
            W D++                NS +     G+++   YFI   ++ +F ++NL + V+  
Sbjct: 1418 WQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMD 1477

Query: 362  EF 363
             F
Sbjct: 1478 NF 1479


>gi|193788538 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 15 [Homo sapiens]
          Length = 2138

 Score =  776 bits (2003), Expect = 0.0
 Identities = 405/869 (46%), Positives = 565/869 (65%), Gaps = 56/869 (6%)

Query: 1146 IVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEE 1205
            +V  P+  ++   K   K      + PPA    +N   +Q N+N +  P P  E   +E+
Sbjct: 790  LVEKPAVGESKEEKIELKSITADGESPPATK--INMDDLQPNENEDKSPYPNPETTGEED 847

Query: 1206 EEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLCHYILNLRYFEMCIL 1251
            EE+     GP+P              MP  S+ FI S+ N  R  CH I+N   F   IL
Sbjct: 848  EEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLIL 907

Query: 1252 MVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRD 1311
              I +SSI+LAAEDPVQ  + RN++L   DYVFT +FT E+++KM   G  LH+G++ R+
Sbjct: 908  FFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRN 967

Query: 1312 LWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVV 1371
             +NILD +VVS +L++F    ++    IN +K LRVLRVLRPL+ I R   LK V  CV 
Sbjct: 968  YFNILDLLVVSVSLISFGIQSSA----INVVKILRVLRVLRPLRAINRAKGLKHVVQCVF 1023

Query: 1372 NSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK- 1430
             +++ + NI+IV  L  F+FA + VQLFKGK + C+D SK+ E +C+G Y+ Y+  EV  
Sbjct: 1024 VAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDH 1083

Query: 1431 --ARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMS 1488
               + R W+  +F +DNVL A++ LFTVST EGWP++L  S+D+  E++GP   YR+E+S
Sbjct: 1084 PIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEIS 1143

Query: 1489 IFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHM 1548
            IF+++Y ++  FF +NIFV  +I+TFQEQG++  +   L+KN+R C+++A+ A+PL R++
Sbjct: 1144 IFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYI 1203

Query: 1549 PQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSL 1608
            P+N+   QY++W  V S  FEY +  +I LNTI L M+ YG S  ++ A+ + N++FT L
Sbjct: 1204 PKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGL 1261

Query: 1609 FSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFG---------------NN 1653
            F++E +LK++AF    YF D WN+FDF+ V+GSI D++++E                 N+
Sbjct: 1262 FTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENS 1321

Query: 1654 FINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQV 1713
             I+++F RLFR  RL+KLL +G  IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQV
Sbjct: 1322 RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV 1381

Query: 1714 FGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPC-- 1771
            FG I ++        D  +I  +NNF+TF QA++LLFR ATGEAW +IML+C+ GK C  
Sbjct: 1382 FGKIALN--------DTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAP 1433

Query: 1772 ---DKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHH 1828
                 NS      CG+ FA FYF+SF  LC+FL++NLFVAVIMDNF+YLTRD SILGPHH
Sbjct: 1434 ESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHH 1493

Query: 1829 LDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADD 1888
            LDE+ R+WAEYDP A GRI + D+ +LLR I PPLG GK CPHRVACKRL+ M++P+  D
Sbjct: 1494 LDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSD 1553

Query: 1889 NTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKS 1948
             TV FN+TL AL+RTAL IK      + +Q + ELR  +  IW   S K LD +V P   
Sbjct: 1554 GTVMFNATLFALVRTALRIKTE---GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGD 1610

Query: 1949 TDLTVGKIYAAMMIMEYYRQSKAKKLQAM 1977
             ++TVGK YA  +I EY+R+ K +K Q +
Sbjct: 1611 DEVTVGKFYATFLIQEYFRKFKKRKEQGL 1639



 Score =  671 bits (1730), Expect = 0.0
 Identities = 383/827 (46%), Positives = 507/827 (61%), Gaps = 64/827 (7%)

Query: 2   ARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQG-----------GQPGAQRMYKQ 50
           + +G   PA +    + AAAG+        GA  S Q            G  G   +   
Sbjct: 18  SNYGSPRPA-HANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTV 76

Query: 51  SMAQRARTMALYNPIPVRQNCLTVNR---SLFLFSEDNVVRKYAKKITEWPPFEYMILAT 107
           S  QR R    Y   P +Q   T  R   +L   +  N +R+    I EW PFE +IL T
Sbjct: 77  SSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLT 133

Query: 108 IIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRN 167
           I ANC+ LA+    P+DD    +  L+  E  F+ IF  EA +K+IA G  FH  +YLRN
Sbjct: 134 IFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRN 193

Query: 168 GWNVMDFVVVLTGILATV----------------GTEFDLRTLRAVRVLRPLKLVSGIPS 211
           GWN++DF++V+ G+ + +                G  FD++ LRA RVLRPL+LVSG+PS
Sbjct: 194 GWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPS 253

Query: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF-EEGTDDIQGES-P 269
           LQVVL SI+KAM+PLL I LL+ F I+I+AIIGLE +MGK H TC+ +EG  D+  E  P
Sbjct: 254 LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 270 APCGTEEP-ARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSN 328
           +PC  E    R C NGT C+P W+GP +GIT FDN  FA+LTVFQCITMEGWTD+LY  N
Sbjct: 314 SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 329 DASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 388
           DA G  W W+YF+ LIIIGSFF+LNLVLGVLSGEF+KERE+ + R  F KLR +QQ+E +
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433

Query: 389 LNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIAS 448
           L GY++WI++AE++    ++   ++  P     R  ++  S+T+ +N E       +  +
Sbjct: 434 LKGYLDWITQAEDIDPENEDEGMDEEKP-----RNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 449 VGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH 508
            G   AR + + +K + S ++ +  R  R   R  VK+  FYW V+ LV LNTL +A  H
Sbjct: 489 CG---ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEH 545

Query: 509 YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIW 568
           YNQP WL++    A    L LF +EM +KMY LG + YF S FN FDC V+ G I E I 
Sbjct: 546 YNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETIL 605

Query: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
              K  +  GISVLR +RLLRIFK+T+YW SL NLV SLLNS++SI SLL LLFLFI++F
Sbjct: 606 VETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIF 665

Query: 629 ALLGMQLFGGQFNFDE-GTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQ-G 686
           +LLGMQLFGG+FNFDE  T  + FD FP +++TVFQILTGEDWN VMYDGI + GG    
Sbjct: 666 SLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 687 GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEV 746
           GM+  IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EEEE   +K         
Sbjct: 726 GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERK--------- 776

Query: 747 AEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREA 793
                   A  +   K+Q+  +KPA  V E +  ++  +++ A  E+
Sbjct: 777 ------KLARTASPEKKQELVEKPA--VGESKEEKIELKSITADGES 815



 Score =  202 bits (513), Expect = 4e-51
 Identities = 176/705 (24%), Positives = 317/705 (44%), Gaps = 120/705 (17%)

Query: 1200 EEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSI 1259
            + K+++    + +       P  ++  L+  NP+RR C  I+  + FE+ IL+ I  + +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1260 ALAAEDPV---QPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNIL 1316
            ALA   P      NA  +N+ R  +Y+F  +FT E  +K+I  GL+ H  AY R+ WN+L
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV-EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198

Query: 1317 DFIVVSGALVAFAFTGNSKGKDINT---------IKSLRVLRVLRPLKTIKRLPKLKAVF 1367
            DFI+V   L +      +K    N          +K+LR  RVLRPL+ +  +P L+ V 
Sbjct: 199  DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258

Query: 1368 DCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC---------- 1417
            + ++ ++  + +I ++ +  + I+A++ ++LF GK  H T  ++E   D           
Sbjct: 259  NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK-MHKTCYNQEGIADVPAEDDPSPCA 317

Query: 1418 --RGKYLLYEKNEVKARDREWKKYEF-HYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
               G     +   V     +  K+   ++DN  +A+LT+F   T EGW  VL    DA  
Sbjct: 318  LETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAV- 376

Query: 1475 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KMMEEY 1525
                     R    I++V   ++  FF +N+ + ++   F ++       GD  K+ E+ 
Sbjct: 377  --------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428

Query: 1526 SLEKNERACIDFAISA---------------KPLTRHMP--------------------- 1549
             LE++ +  +D+   A               KP    MP                     
Sbjct: 429  QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 1550 ----------QNKQSFQYRMWQ---------FVVSPPFEYTIMAMIALNTIVLMMKFYGA 1590
                      ++K S  +R W           V S  F + ++ ++ LNT+ +  + Y  
Sbjct: 489  CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548

Query: 1591 SVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITD-ILVTE 1649
                       N    +LF+ E +LK+ + G+  YF   +N FD   V G I + ILV  
Sbjct: 549  PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 1650 FGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAII 1709
               + + +S LR  R  R+ K+ R   ++  L+ + + S +++  + LL+ +   I++++
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 1710 GMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGK 1769
            GMQ+FG           + DE Q T  + F  F Q+L+ +F+  TGE W+++M   +   
Sbjct: 669  GMQLFGG--------KFNFDEMQ-TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAY 719

Query: 1770 PCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
                  G+L           YF+  +F+C ++++LN+F+A+ +DN
Sbjct: 720  GGPSFPGML--------VCIYFI-ILFICGNYILLNVFLAIAVDN 755



 Score =  143 bits (360), Expect = 2e-33
 Identities = 179/785 (22%), Positives = 325/785 (41%), Gaps = 161/785 (20%)

Query: 33   AGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAK 92
            AGG  +G   GA+  ++ S ++ +R    +N    R+ C    +S       NV      
Sbjct: 480  AGGDIEGENCGARLAHRISKSKFSRYWRRWNRF-CRRKCRAAVKS-------NV------ 525

Query: 93   KITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKI 152
                   F ++++  +  N + +A E +   +    ++E  D      + +F  E  +K+
Sbjct: 526  -------FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKM 575

Query: 153  IALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------FDLRTLRAVRVLRPLKLV 206
             +LG      +Y  + +N  D  VV  GIL T+  E        +  LR VR+LR  K+ 
Sbjct: 576  YSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKIT 631

Query: 207  SGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQG 266
                SL  ++ S++ ++  +  + LLLF  I+IF+++G++ + GKF+        D++Q 
Sbjct: 632  RYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF-------DEMQT 684

Query: 267  ESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYN 326
                                            + FDN   ++LTVFQ +T E W  ++Y+
Sbjct: 685  RR------------------------------STFDNFPQSLLTVFQILTGEDWNSVMYD 714

Query: 327  SNDASGNT-----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERE 368
               A G          +YFI L I G++ +LN+ L +     A             +E+E
Sbjct: 715  GIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKE 774

Query: 369  RVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIK- 427
            R +  R     ++Q+ +E+   G     SK E++ L     DGE   P    +    ++ 
Sbjct: 775  RKKLARTASPEKKQELVEKPAVGE----SKEEKIELKSITADGES--PPATKINMDDLQP 828

Query: 428  ---KSKTDLLNPEEA--EDQLADIASVGS---PFARASIKSAKL---ENSTFF-HKKERR 475
               + K+   NPE    ED+      VG    P +   +K   +   E S FF      R
Sbjct: 829  NENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNR 888

Query: 476  MRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ-PEWLSDFLYYAEFIFLGLFMSEM 534
             R    R+V    F   +L  + L+++ +A     Q   + +  L  A+++F  +F  E+
Sbjct: 889  FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEI 948

Query: 535  FIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRI 590
             +KM   G       +  + FN  D  V+  S+       I+      + +LR LR+LR 
Sbjct: 949  ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRP 1005

Query: 591  FKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQ-FNFDEGTPPT 649
             +       L+++V  +  ++++I +++ +  L   +FA +G+QLF G+ +   + +  T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 650  -------------------------------NFDTFPAAIMTVFQILTGEDWNEVMYDGI 678
                                           +FD   AA+M +F + T E W E++Y  I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 679  KSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEA 733
             S    +G +       SI+FI+  +   + ++N+F+   +        +T  EQ E+E 
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEY 1177

Query: 734  ANQKL 738
             N +L
Sbjct: 1178 KNCEL 1182



 Score =  116 bits (291), Expect = 2e-25
 Identities = 96/331 (29%), Positives = 163/331 (49%), Gaps = 33/331 (9%)

Query: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
            + F+FS +N  R    +I     F  +IL  I+ + I LA E   P    +  +  L + 
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILGNA 936

Query: 137  EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV   ++ + G +      ++
Sbjct: 937  DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLI-SFGIQSSAINVVK 995

Query: 193  TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      +FA IG++ + GK 
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 253  HTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----WEGPNNGITQFDNILFA 307
            +T        D   ++ A C  +    T  +G    P      WE   N    FDN+L A
Sbjct: 1056 YT------CSDSSKQTEAEC--KGNYITYKDGEVDHPIIQPRSWE---NSKFDFDNVLAA 1104

Query: 308  VLTVFQCITMEGWTDLLYNSNDA----SGNTWNW-----LYFIPLIIIGSFFMLNLVLGV 358
            ++ +F   T EGW +LLY S D+     G  +N+     ++FI  III +FFM+N+ +G 
Sbjct: 1105 MMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGF 1164

Query: 359  LSGEFAKERERVENRRAFLKLRRQQQIEREL 389
            +   F ++ E+ E +   L   ++Q +E  L
Sbjct: 1165 VIVTFQEQGEQ-EYKNCELDKNQRQCVEYAL 1194



 Score =  114 bits (286), Expect = 8e-25
 Identities = 77/294 (26%), Positives = 138/294 (46%), Gaps = 42/294 (14%)

Query: 472  KERRMRFYIRR---------MVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 522
            K R +R YI +         +V +  F + +  L+ LNT+C+A+ HY Q       +   
Sbjct: 1195 KARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNIL 1254

Query: 523  EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKP--------- 573
              +F GLF  EM +K+     + YF   +N FD  ++IGSI +VI +   P         
Sbjct: 1255 NMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPS 1314

Query: 574  -----GTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
                  +   I+  R  R++R+ K+      +R L+ + + S +++  +  L+ +   ++
Sbjct: 1315 MNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIY 1374

Query: 629  ALLGMQLFG--GQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMY----------- 675
            A++GMQ+FG     +  E     NF TFP A++ +F+  TGE W ++M            
Sbjct: 1375 AVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPE 1434

Query: 676  --DGIKSQGGVQGGMVFSI-YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
                  ++G    G  F++ YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1435 SEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 79/311 (25%), Positives = 143/311 (45%), Gaps = 41/311 (13%)

Query: 1234 RRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMV 1293
            RR C   +    F   ++ ++ ++++ +A+E   QPN     V    +     +FT EM+
Sbjct: 514  RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW-LTEVQDTANKALLALFTAEML 572

Query: 1294 IKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRP 1353
            +KM  LGL     AYF  L+N  D  VV G ++            +  I  LR +R+LR 
Sbjct: 573  LKMYSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLG-ISVLRCVRLLRI 627

Query: 1354 LKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEF 1413
             K  +    L  +   ++NS++++ ++L++  LF+ IF+++ +QLF GKF          
Sbjct: 628  FKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF---------- 677

Query: 1414 EKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDAT 1473
                         +E++ R          +DN   +LLT+F + TGE W  V+    D  
Sbjct: 678  -----------NFDEMQTRRST-------FDNFPQSLLTVFQILTGEDWNSVM---YDGI 716

Query: 1474 FENQGPS-PGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNER 1532
                GPS PG  M + I++++ F+   +  +N+F+A+ +    +  + +      E+ E+
Sbjct: 717  MAYGGPSFPG--MLVCIYFIILFICGNYILLNVFLAIAVDNLAD-AESLTSAQKEEEEEK 773

Query: 1533 ACIDFAISAKP 1543
                 A +A P
Sbjct: 774  ERKKLARTASP 784



 Score = 82.0 bits (201), Expect = 6e-15
 Identities = 73/297 (24%), Positives = 130/297 (43%), Gaps = 62/297 (20%)

Query: 1567 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1623
            PFE  I+  I  N + L +        S A  + L     +F  +F++E  LKV+A+G+L
Sbjct: 125  PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1624 ----NYFRDAWNIFDFVTVLGSITDILVTEF----GNNFI-------NLSFLRLFRAARL 1668
                 Y R+ WN+ DF+ V+  +   ++ +     G N +       ++  LR FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1669 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF---------GNIGI 1719
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F            GI
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1720 -DVEDEDSDEDEFQITEH---------------------NNFRTFFQALMLLFRSATGEA 1757
             DV  ED        T H                      NF  F  A++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1758 WHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
            W +++               +    G ++ + YFV+ I + SF +LNL + V+   F
Sbjct: 365  WTDVLY-------------WVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 70/302 (23%), Positives = 120/302 (39%), Gaps = 81/302 (26%)

Query: 100  FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
            FEY++   I+ N I LA++ +            ++     F G+F  E  +K+IA    F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273

Query: 160  HKGSYLRNGWNVMDFVVVLTGILATVGTE--------------------FDLRTLRAVRV 199
                Y  + WNV DF++V+  I+  + +E                      +   R  RV
Sbjct: 1274 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333

Query: 200  LRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEE 259
            +R +KL+S    ++ +L + +K+   L  + LL+     I+A+IG++ + GK        
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI------- 1385

Query: 260  GTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEG 319
                      A   T E  R               NN    F     AVL +F+C T E 
Sbjct: 1386 ----------ALNDTTEINR---------------NNNFQTFPQ---AVLLLFRCATGEA 1417

Query: 320  WTDLLY---------------NSNDAS---GNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
            W D++                NS +     G+++   YFI   ++ +F ++NL + V+  
Sbjct: 1418 WQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMD 1477

Query: 362  EF 363
             F
Sbjct: 1478 NF 1479


>gi|193794828 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 7 [Homo sapiens]
          Length = 2157

 Score =  775 bits (2001), Expect = 0.0
 Identities = 409/885 (46%), Positives = 569/885 (64%), Gaps = 69/885 (7%)

Query: 1146 IVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEE 1205
            +V  P+  ++   K   K      + PPA    +N   +Q N+N +  P P  E   +E+
Sbjct: 790  LVEKPAVGESKEEKIELKSITADGESPPATK--INMDDLQPNENEDKSPYPNPETTGEED 847

Query: 1206 EEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLCHYILNLRYFEMCIL 1251
            EE+     GP+P              MP  S+ FI S+ N  R  CH I+N   F   IL
Sbjct: 848  EEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLIL 907

Query: 1252 MVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRD 1311
              I +SSI+LAAEDPVQ  + RN++L YFD VFT +FT E+ +KM   G  LH+G++ R+
Sbjct: 908  FFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRN 967

Query: 1312 LWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVV 1371
             +NILD +VVS +L++F    ++    IN +K LRVLRVLRPL+ I R   LK V  CV 
Sbjct: 968  YFNILDLLVVSVSLISFGIQSSA----INVVKILRVLRVLRPLRAINRAKGLKHVVQCVF 1023

Query: 1372 NSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK- 1430
             +++ + NI+IV  L  F+FA + VQLFKGK + C+D SK+ E +C+G Y+ Y+  EV  
Sbjct: 1024 VAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDH 1083

Query: 1431 --ARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMS 1488
               + R W+  +F +DNVL A++ LFTVST EGWP++L  S+D+  E++GP   YR+E+S
Sbjct: 1084 PIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEIS 1143

Query: 1489 IFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHM 1548
            IF+++Y ++  FF +NIFV  +I+TFQEQG++  +   L+KN+R C+++A+ A+PL R++
Sbjct: 1144 IFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYI 1203

Query: 1549 PQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSL 1608
            P+N+   QY++W  V S  FEY +  +I LNTI L M+ YG S  ++ A+ + N++FT L
Sbjct: 1204 PKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGL 1261

Query: 1609 FSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFG---------------NN 1653
            F++E +LK++AF    YF D WN+FDF+ V+GSI D++++E                 N+
Sbjct: 1262 FTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENS 1321

Query: 1654 FINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQV 1713
             I+++F RLFR  RL+KLL +G  IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQV
Sbjct: 1322 RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV 1381

Query: 1714 FGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPC-- 1771
            FG I ++        D  +I  +NNF+TF QA++LLFR ATGEAW +IML+C+ GK C  
Sbjct: 1382 FGKIALN--------DTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAP 1433

Query: 1772 ---DKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHH 1828
                 NS      CG+ FA FYF+SF  LC+FL++NLFVAVIMDNF+YLTRD SILGPHH
Sbjct: 1434 ESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHH 1493

Query: 1829 LDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADD 1888
            LDE+ R+WAEYDP A GRI + D+ +LLR I PPLG GK CPHRVACKRL+ M++P+  D
Sbjct: 1494 LDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSD 1553

Query: 1889 NTVHFNSTLMALIRTALDIKIAKG--------GADK--------QQMDAELRKEMMAIWP 1932
             TV FN+TL AL+RTAL IK  +G        GA+         +Q + ELR  +  IW 
Sbjct: 1554 GTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWK 1613

Query: 1933 NLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAM 1977
              S K LD +V P    ++TVGK YA  +I EY+R+ K +K Q +
Sbjct: 1614 RTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGL 1658



 Score =  671 bits (1730), Expect = 0.0
 Identities = 383/827 (46%), Positives = 507/827 (61%), Gaps = 64/827 (7%)

Query: 2   ARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQG-----------GQPGAQRMYKQ 50
           + +G   PA +    + AAAG+        GA  S Q            G  G   +   
Sbjct: 18  SNYGSPRPA-HANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTV 76

Query: 51  SMAQRARTMALYNPIPVRQNCLTVNR---SLFLFSEDNVVRKYAKKITEWPPFEYMILAT 107
           S  QR R    Y   P +Q   T  R   +L   +  N +R+    I EW PFE +IL T
Sbjct: 77  SSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLT 133

Query: 108 IIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRN 167
           I ANC+ LA+    P+DD    +  L+  E  F+ IF  EA +K+IA G  FH  +YLRN
Sbjct: 134 IFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRN 193

Query: 168 GWNVMDFVVVLTGILATV----------------GTEFDLRTLRAVRVLRPLKLVSGIPS 211
           GWN++DF++V+ G+ + +                G  FD++ LRA RVLRPL+LVSG+PS
Sbjct: 194 GWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPS 253

Query: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF-EEGTDDIQGES-P 269
           LQVVL SI+KAM+PLL I LL+ F I+I+AIIGLE +MGK H TC+ +EG  D+  E  P
Sbjct: 254 LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 270 APCGTEEP-ARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSN 328
           +PC  E    R C NGT C+P W+GP +GIT FDN  FA+LTVFQCITMEGWTD+LY  N
Sbjct: 314 SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 329 DASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 388
           DA G  W W+YF+ LIIIGSFF+LNLVLGVLSGEF+KERE+ + R  F KLR +QQ+E +
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433

Query: 389 LNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIAS 448
           L GY++WI++AE++    ++   ++  P     R  ++  S+T+ +N E       +  +
Sbjct: 434 LKGYLDWITQAEDIDPENEDEGMDEEKP-----RNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 449 VGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH 508
            G   AR + + +K + S ++ +  R  R   R  VK+  FYW V+ LV LNTL +A  H
Sbjct: 489 CG---ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEH 545

Query: 509 YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIW 568
           YNQP WL++    A    L LF +EM +KMY LG + YF S FN FDC V+ G I E I 
Sbjct: 546 YNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETIL 605

Query: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
              K  +  GISVLR +RLLRIFK+T+YW SL NLV SLLNS++SI SLL LLFLFI++F
Sbjct: 606 VETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIF 665

Query: 629 ALLGMQLFGGQFNFDE-GTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQ-G 686
           +LLGMQLFGG+FNFDE  T  + FD FP +++TVFQILTGEDWN VMYDGI + GG    
Sbjct: 666 SLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 687 GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEV 746
           GM+  IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EEEE   +K         
Sbjct: 726 GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERK--------- 776

Query: 747 AEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREA 793
                   A  +   K+Q+  +KPA  V E +  ++  +++ A  E+
Sbjct: 777 ------KLARTASPEKKQELVEKPA--VGESKEEKIELKSITADGES 815



 Score =  202 bits (513), Expect = 4e-51
 Identities = 176/705 (24%), Positives = 317/705 (44%), Gaps = 120/705 (17%)

Query: 1200 EEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSI 1259
            + K+++    + +       P  ++  L+  NP+RR C  I+  + FE+ IL+ I  + +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1260 ALAAEDPV---QPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNIL 1316
            ALA   P      NA  +N+ R  +Y+F  +FT E  +K+I  GL+ H  AY R+ WN+L
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV-EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198

Query: 1317 DFIVVSGALVAFAFTGNSKGKDINT---------IKSLRVLRVLRPLKTIKRLPKLKAVF 1367
            DFI+V   L +      +K    N          +K+LR  RVLRPL+ +  +P L+ V 
Sbjct: 199  DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258

Query: 1368 DCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC---------- 1417
            + ++ ++  + +I ++ +  + I+A++ ++LF GK  H T  ++E   D           
Sbjct: 259  NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK-MHKTCYNQEGIADVPAEDDPSPCA 317

Query: 1418 --RGKYLLYEKNEVKARDREWKKYEF-HYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
               G     +   V     +  K+   ++DN  +A+LT+F   T EGW  VL    DA  
Sbjct: 318  LETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAV- 376

Query: 1475 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KMMEEY 1525
                     R    I++V   ++  FF +N+ + ++   F ++       GD  K+ E+ 
Sbjct: 377  --------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428

Query: 1526 SLEKNERACIDFAISA---------------KPLTRHMP--------------------- 1549
             LE++ +  +D+   A               KP    MP                     
Sbjct: 429  QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 1550 ----------QNKQSFQYRMWQ---------FVVSPPFEYTIMAMIALNTIVLMMKFYGA 1590
                      ++K S  +R W           V S  F + ++ ++ LNT+ +  + Y  
Sbjct: 489  CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548

Query: 1591 SVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITD-ILVTE 1649
                       N    +LF+ E +LK+ + G+  YF   +N FD   V G I + ILV  
Sbjct: 549  PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 1650 FGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAII 1709
               + + +S LR  R  R+ K+ R   ++  L+ + + S +++  + LL+ +   I++++
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 1710 GMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGK 1769
            GMQ+FG           + DE Q T  + F  F Q+L+ +F+  TGE W+++M   +   
Sbjct: 669  GMQLFGG--------KFNFDEMQ-TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAY 719

Query: 1770 PCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
                  G+L           YF+  +F+C ++++LN+F+A+ +DN
Sbjct: 720  GGPSFPGML--------VCIYFI-ILFICGNYILLNVFLAIAVDN 755



 Score =  144 bits (362), Expect = 1e-33
 Identities = 179/785 (22%), Positives = 325/785 (41%), Gaps = 161/785 (20%)

Query: 33   AGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAK 92
            AGG  +G   GA+  ++ S ++ +R    +N    R+ C    +S       NV      
Sbjct: 480  AGGDIEGENCGARLAHRISKSKFSRYWRRWNRF-CRRKCRAAVKS-------NV------ 525

Query: 93   KITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKI 152
                   F ++++  +  N + +A E +   +    ++E  D      + +F  E  +K+
Sbjct: 526  -------FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKM 575

Query: 153  IALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------FDLRTLRAVRVLRPLKLV 206
             +LG      +Y  + +N  D  VV  GIL T+  E        +  LR VR+LR  K+ 
Sbjct: 576  YSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKIT 631

Query: 207  SGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQG 266
                SL  ++ S++ ++  +  + LLLF  I+IF+++G++ + GKF+        D++Q 
Sbjct: 632  RYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF-------DEMQT 684

Query: 267  ESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYN 326
                                            + FDN   ++LTVFQ +T E W  ++Y+
Sbjct: 685  RR------------------------------STFDNFPQSLLTVFQILTGEDWNSVMYD 714

Query: 327  SNDASGNT-----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERE 368
               A G          +YFI L I G++ +LN+ L +     A             +E+E
Sbjct: 715  GIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKE 774

Query: 369  RVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIK- 427
            R +  R     ++Q+ +E+   G     SK E++ L     DGE   P    +    ++ 
Sbjct: 775  RKKLARTASPEKKQELVEKPAVGE----SKEEKIELKSITADGES--PPATKINMDDLQP 828

Query: 428  ---KSKTDLLNPEEA--EDQLADIASVGS---PFARASIKSAKL---ENSTFF-HKKERR 475
               + K+   NPE    ED+      VG    P +   +K   +   E S FF      R
Sbjct: 829  NENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNR 888

Query: 476  MRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ-PEWLSDFLYYAEFIFLGLFMSEM 534
             R    R+V    F   +L  + L+++ +A     Q   + +  L+Y + +F  +F  E+
Sbjct: 889  FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEI 948

Query: 535  FIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRI 590
             +KM   G       +  + FN  D  V+  S+       I+      + +LR LR+LR 
Sbjct: 949  ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRP 1005

Query: 591  FKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQ-FNFDEGTPPT 649
             +       L+++V  +  ++++I +++ +  L   +FA +G+QLF G+ +   + +  T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 650  -------------------------------NFDTFPAAIMTVFQILTGEDWNEVMYDGI 678
                                           +FD   AA+M +F + T E W E++Y  I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 679  KSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEA 733
             S    +G +       SI+FI+  +   + ++N+F+   +        +T  EQ E+E 
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEY 1177

Query: 734  ANQKL 738
             N +L
Sbjct: 1178 KNCEL 1182



 Score =  114 bits (286), Expect = 8e-25
 Identities = 77/294 (26%), Positives = 138/294 (46%), Gaps = 42/294 (14%)

Query: 472  KERRMRFYIRR---------MVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 522
            K R +R YI +         +V +  F + +  L+ LNT+C+A+ HY Q       +   
Sbjct: 1195 KARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNIL 1254

Query: 523  EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKP--------- 573
              +F GLF  EM +K+     + YF   +N FD  ++IGSI +VI +   P         
Sbjct: 1255 NMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPS 1314

Query: 574  -----GTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
                  +   I+  R  R++R+ K+      +R L+ + + S +++  +  L+ +   ++
Sbjct: 1315 MNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIY 1374

Query: 629  ALLGMQLFG--GQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMY----------- 675
            A++GMQ+FG     +  E     NF TFP A++ +F+  TGE W ++M            
Sbjct: 1375 AVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPE 1434

Query: 676  --DGIKSQGGVQGGMVFSI-YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
                  ++G    G  F++ YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1435 SEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485



 Score =  114 bits (285), Expect = 1e-24
 Identities = 96/331 (29%), Positives = 162/331 (48%), Gaps = 33/331 (9%)

Query: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
            + F+FS +N  R    +I     F  +IL  I+ + I LA E   P    +  +  L   
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 936

Query: 137  EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV   ++ + G +      ++
Sbjct: 937  DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLI-SFGIQSSAINVVK 995

Query: 193  TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      +FA IG++ + GK 
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 253  HTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----WEGPNNGITQFDNILFA 307
            +T        D   ++ A C  +    T  +G    P      WE   N    FDN+L A
Sbjct: 1056 YT------CSDSSKQTEAEC--KGNYITYKDGEVDHPIIQPRSWE---NSKFDFDNVLAA 1104

Query: 308  VLTVFQCITMEGWTDLLYNSNDA----SGNTWNW-----LYFIPLIIIGSFFMLNLVLGV 358
            ++ +F   T EGW +LLY S D+     G  +N+     ++FI  III +FFM+N+ +G 
Sbjct: 1105 MMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGF 1164

Query: 359  LSGEFAKERERVENRRAFLKLRRQQQIEREL 389
            +   F ++ E+ E +   L   ++Q +E  L
Sbjct: 1165 VIVTFQEQGEQ-EYKNCELDKNQRQCVEYAL 1194



 Score = 82.0 bits (201), Expect = 6e-15
 Identities = 73/297 (24%), Positives = 130/297 (43%), Gaps = 62/297 (20%)

Query: 1567 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1623
            PFE  I+  I  N + L +        S A  + L     +F  +F++E  LKV+A+G+L
Sbjct: 125  PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1624 ----NYFRDAWNIFDFVTVLGSITDILVTEF----GNNFI-------NLSFLRLFRAARL 1668
                 Y R+ WN+ DF+ V+  +   ++ +     G N +       ++  LR FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1669 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF---------GNIGI 1719
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F            GI
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1720 -DVEDEDSDEDEFQITEH---------------------NNFRTFFQALMLLFRSATGEA 1757
             DV  ED        T H                      NF  F  A++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1758 WHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
            W +++               +    G ++ + YFV+ I + SF +LNL + V+   F
Sbjct: 365  WTDVLY-------------WVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 70/302 (23%), Positives = 120/302 (39%), Gaps = 81/302 (26%)

Query: 100  FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
            FEY++   I+ N I LA++ +            ++     F G+F  E  +K+IA    F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273

Query: 160  HKGSYLRNGWNVMDFVVVLTGILATVGTE--------------------FDLRTLRAVRV 199
                Y  + WNV DF++V+  I+  + +E                      +   R  RV
Sbjct: 1274 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333

Query: 200  LRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEE 259
            +R +KL+S    ++ +L + +K+   L  + LL+     I+A+IG++ + GK        
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI------- 1385

Query: 260  GTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEG 319
                      A   T E  R               NN    F     AVL +F+C T E 
Sbjct: 1386 ----------ALNDTTEINR---------------NNNFQTFPQ---AVLLLFRCATGEA 1417

Query: 320  WTDLLY---------------NSNDAS---GNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
            W D++                NS +     G+++   YFI   ++ +F ++NL + V+  
Sbjct: 1418 WQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMD 1477

Query: 362  EF 363
             F
Sbjct: 1478 NF 1479


>gi|193788730 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 4 [Homo sapiens]
          Length = 2173

 Score =  775 bits (2000), Expect = 0.0
 Identities = 407/869 (46%), Positives = 564/869 (64%), Gaps = 56/869 (6%)

Query: 1146 IVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEE 1205
            +V  P+  ++   K   K      + PPA    +N   +Q N+N +  P P  E   +E+
Sbjct: 790  LVEKPAVGESKEEKIELKSITADGESPPATK--INMDDLQPNENEDKSPYPNPETTGEED 847

Query: 1206 EEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLCHYILNLRYFEMCIL 1251
            EE+     GP+P              MP  S+ FI S+ N  R  CH I+N   F   IL
Sbjct: 848  EEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLIL 907

Query: 1252 MVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRD 1311
              I +SSI+LAAEDPVQ  + RN++L   DYVFT +FT E+++KM   G  LH+G++ R+
Sbjct: 908  FFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRN 967

Query: 1312 LWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVV 1371
             +NILD +VVS +L++F    ++    IN +K LRVLRVLRPL+ I R   LK V  CV 
Sbjct: 968  YFNILDLLVVSVSLISFGIQSSA----INVVKILRVLRVLRPLRAINRAKGLKHVVQCVF 1023

Query: 1372 NSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK- 1430
             +++ + NI+IV  L  F+FA + VQLFKGK + C+D SK+ E +C+G Y+ Y+  EV  
Sbjct: 1024 VAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDH 1083

Query: 1431 --ARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMS 1488
               + R W+  +F +DNVL A++ LFTVST EGWP++L  S+D+  E++GP   YR+E+S
Sbjct: 1084 PIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEIS 1143

Query: 1489 IFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHM 1548
            IF+++Y ++  FF +NIFV  +I+TFQEQG++  +   L+KN+R C+++A+ A+PL R++
Sbjct: 1144 IFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYI 1203

Query: 1549 PQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSL 1608
            P+N+   QY++W  V S  FEY +  +I LNTI L M+ YG S  ++ A+ + N++FT L
Sbjct: 1204 PKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGL 1261

Query: 1609 FSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFG---------------NN 1653
            F++E +LK++AF   +YF DAWN FD + V+GSI DI +TE                 N+
Sbjct: 1262 FTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENS 1321

Query: 1654 FINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQV 1713
             I+++F RLFR  RL+KLL +G  IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQV
Sbjct: 1322 RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV 1381

Query: 1714 FGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPC-- 1771
            FG I ++        D  +I  +NNF+TF QA++LLFR ATGEAW +IML+C+ GK C  
Sbjct: 1382 FGKIALN--------DTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAP 1433

Query: 1772 ---DKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHH 1828
                 NS      CG+ FA FYF+SF  LC+FL++NLFVAVIMDNF+YLTRD SILGPHH
Sbjct: 1434 ESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHH 1493

Query: 1829 LDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADD 1888
            LDE+ R+WAEYDP A GRI + D+ +LLR I PPLG GK CPHRVACKRL+ M++P+  D
Sbjct: 1494 LDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSD 1553

Query: 1889 NTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKS 1948
             TV FN+TL AL+RTAL IK      + +Q + ELR  +  IW   S K LD +V P   
Sbjct: 1554 GTVMFNATLFALVRTALRIKTE---GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGD 1610

Query: 1949 TDLTVGKIYAAMMIMEYYRQSKAKKLQAM 1977
             ++TVGK YA  +I EY+R+ K +K Q +
Sbjct: 1611 DEVTVGKFYATFLIQEYFRKFKKRKEQGL 1639



 Score =  671 bits (1730), Expect = 0.0
 Identities = 383/827 (46%), Positives = 507/827 (61%), Gaps = 64/827 (7%)

Query: 2   ARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQG-----------GQPGAQRMYKQ 50
           + +G   PA +    + AAAG+        GA  S Q            G  G   +   
Sbjct: 18  SNYGSPRPA-HANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTV 76

Query: 51  SMAQRARTMALYNPIPVRQNCLTVNR---SLFLFSEDNVVRKYAKKITEWPPFEYMILAT 107
           S  QR R    Y   P +Q   T  R   +L   +  N +R+    I EW PFE +IL T
Sbjct: 77  SSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLT 133

Query: 108 IIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRN 167
           I ANC+ LA+    P+DD    +  L+  E  F+ IF  EA +K+IA G  FH  +YLRN
Sbjct: 134 IFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRN 193

Query: 168 GWNVMDFVVVLTGILATV----------------GTEFDLRTLRAVRVLRPLKLVSGIPS 211
           GWN++DF++V+ G+ + +                G  FD++ LRA RVLRPL+LVSG+PS
Sbjct: 194 GWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPS 253

Query: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF-EEGTDDIQGES-P 269
           LQVVL SI+KAM+PLL I LL+ F I+I+AIIGLE +MGK H TC+ +EG  D+  E  P
Sbjct: 254 LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 270 APCGTEEP-ARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSN 328
           +PC  E    R C NGT C+P W+GP +GIT FDN  FA+LTVFQCITMEGWTD+LY  N
Sbjct: 314 SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 329 DASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 388
           DA G  W W+YF+ LIIIGSFF+LNLVLGVLSGEF+KERE+ + R  F KLR +QQ+E +
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433

Query: 389 LNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIAS 448
           L GY++WI++AE++    ++   ++  P     R  ++  S+T+ +N E       +  +
Sbjct: 434 LKGYLDWITQAEDIDPENEDEGMDEEKP-----RNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 449 VGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH 508
            G   AR + + +K + S ++ +  R  R   R  VK+  FYW V+ LV LNTL +A  H
Sbjct: 489 CG---ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEH 545

Query: 509 YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIW 568
           YNQP WL++    A    L LF +EM +KMY LG + YF S FN FDC V+ G I E I 
Sbjct: 546 YNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETIL 605

Query: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
              K  +  GISVLR +RLLRIFK+T+YW SL NLV SLLNS++SI SLL LLFLFI++F
Sbjct: 606 VETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIF 665

Query: 629 ALLGMQLFGGQFNFDE-GTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQ-G 686
           +LLGMQLFGG+FNFDE  T  + FD FP +++TVFQILTGEDWN VMYDGI + GG    
Sbjct: 666 SLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 687 GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEV 746
           GM+  IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EEEE   +K         
Sbjct: 726 GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERK--------- 776

Query: 747 AEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREA 793
                   A  +   K+Q+  +KPA  V E +  ++  +++ A  E+
Sbjct: 777 ------KLARTASPEKKQELVEKPA--VGESKEEKIELKSITADGES 815



 Score =  202 bits (513), Expect = 4e-51
 Identities = 176/705 (24%), Positives = 317/705 (44%), Gaps = 120/705 (17%)

Query: 1200 EEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSI 1259
            + K+++    + +       P  ++  L+  NP+RR C  I+  + FE+ IL+ I  + +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1260 ALAAEDPV---QPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNIL 1316
            ALA   P      NA  +N+ R  +Y+F  +FT E  +K+I  GL+ H  AY R+ WN+L
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV-EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198

Query: 1317 DFIVVSGALVAFAFTGNSKGKDINT---------IKSLRVLRVLRPLKTIKRLPKLKAVF 1367
            DFI+V   L +      +K    N          +K+LR  RVLRPL+ +  +P L+ V 
Sbjct: 199  DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258

Query: 1368 DCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC---------- 1417
            + ++ ++  + +I ++ +  + I+A++ ++LF GK  H T  ++E   D           
Sbjct: 259  NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK-MHKTCYNQEGIADVPAEDDPSPCA 317

Query: 1418 --RGKYLLYEKNEVKARDREWKKYEF-HYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
               G     +   V     +  K+   ++DN  +A+LT+F   T EGW  VL    DA  
Sbjct: 318  LETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAV- 376

Query: 1475 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KMMEEY 1525
                     R    I++V   ++  FF +N+ + ++   F ++       GD  K+ E+ 
Sbjct: 377  --------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428

Query: 1526 SLEKNERACIDFAISA---------------KPLTRHMP--------------------- 1549
             LE++ +  +D+   A               KP    MP                     
Sbjct: 429  QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 1550 ----------QNKQSFQYRMWQ---------FVVSPPFEYTIMAMIALNTIVLMMKFYGA 1590
                      ++K S  +R W           V S  F + ++ ++ LNT+ +  + Y  
Sbjct: 489  CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548

Query: 1591 SVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITD-ILVTE 1649
                       N    +LF+ E +LK+ + G+  YF   +N FD   V G I + ILV  
Sbjct: 549  PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 1650 FGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAII 1709
               + + +S LR  R  R+ K+ R   ++  L+ + + S +++  + LL+ +   I++++
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 1710 GMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGK 1769
            GMQ+FG           + DE Q T  + F  F Q+L+ +F+  TGE W+++M   +   
Sbjct: 669  GMQLFGG--------KFNFDEMQ-TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAY 719

Query: 1770 PCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
                  G+L           YF+  +F+C ++++LN+F+A+ +DN
Sbjct: 720  GGPSFPGML--------VCIYFI-ILFICGNYILLNVFLAIAVDN 755



 Score =  143 bits (360), Expect = 2e-33
 Identities = 179/785 (22%), Positives = 325/785 (41%), Gaps = 161/785 (20%)

Query: 33   AGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAK 92
            AGG  +G   GA+  ++ S ++ +R    +N    R+ C    +S       NV      
Sbjct: 480  AGGDIEGENCGARLAHRISKSKFSRYWRRWNRF-CRRKCRAAVKS-------NV------ 525

Query: 93   KITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKI 152
                   F ++++  +  N + +A E +   +    ++E  D      + +F  E  +K+
Sbjct: 526  -------FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKM 575

Query: 153  IALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------FDLRTLRAVRVLRPLKLV 206
             +LG      +Y  + +N  D  VV  GIL T+  E        +  LR VR+LR  K+ 
Sbjct: 576  YSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKIT 631

Query: 207  SGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQG 266
                SL  ++ S++ ++  +  + LLLF  I+IF+++G++ + GKF+        D++Q 
Sbjct: 632  RYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF-------DEMQT 684

Query: 267  ESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYN 326
                                            + FDN   ++LTVFQ +T E W  ++Y+
Sbjct: 685  RR------------------------------STFDNFPQSLLTVFQILTGEDWNSVMYD 714

Query: 327  SNDASGNT-----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERE 368
               A G          +YFI L I G++ +LN+ L +     A             +E+E
Sbjct: 715  GIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKE 774

Query: 369  RVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIK- 427
            R +  R     ++Q+ +E+   G     SK E++ L     DGE   P    +    ++ 
Sbjct: 775  RKKLARTASPEKKQELVEKPAVGE----SKEEKIELKSITADGES--PPATKINMDDLQP 828

Query: 428  ---KSKTDLLNPEEA--EDQLADIASVGS---PFARASIKSAKL---ENSTFF-HKKERR 475
               + K+   NPE    ED+      VG    P +   +K   +   E S FF      R
Sbjct: 829  NENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNR 888

Query: 476  MRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ-PEWLSDFLYYAEFIFLGLFMSEM 534
             R    R+V    F   +L  + L+++ +A     Q   + +  L  A+++F  +F  E+
Sbjct: 889  FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEI 948

Query: 535  FIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRI 590
             +KM   G       +  + FN  D  V+  S+       I+      + +LR LR+LR 
Sbjct: 949  ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRP 1005

Query: 591  FKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQ-FNFDEGTPPT 649
             +       L+++V  +  ++++I +++ +  L   +FA +G+QLF G+ +   + +  T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 650  -------------------------------NFDTFPAAIMTVFQILTGEDWNEVMYDGI 678
                                           +FD   AA+M +F + T E W E++Y  I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 679  KSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEA 733
             S    +G +       SI+FI+  +   + ++N+F+   +        +T  EQ E+E 
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEY 1177

Query: 734  ANQKL 738
             N +L
Sbjct: 1178 KNCEL 1182



 Score =  116 bits (291), Expect = 2e-25
 Identities = 96/331 (29%), Positives = 163/331 (49%), Gaps = 33/331 (9%)

Query: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
            + F+FS +N  R    +I     F  +IL  I+ + I LA E   P    +  +  L + 
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILGNA 936

Query: 137  EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV   ++ + G +      ++
Sbjct: 937  DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLI-SFGIQSSAINVVK 995

Query: 193  TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      +FA IG++ + GK 
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 253  HTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----WEGPNNGITQFDNILFA 307
            +T        D   ++ A C  +    T  +G    P      WE   N    FDN+L A
Sbjct: 1056 YT------CSDSSKQTEAEC--KGNYITYKDGEVDHPIIQPRSWE---NSKFDFDNVLAA 1104

Query: 308  VLTVFQCITMEGWTDLLYNSNDA----SGNTWNW-----LYFIPLIIIGSFFMLNLVLGV 358
            ++ +F   T EGW +LLY S D+     G  +N+     ++FI  III +FFM+N+ +G 
Sbjct: 1105 MMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGF 1164

Query: 359  LSGEFAKERERVENRRAFLKLRRQQQIEREL 389
            +   F ++ E+ E +   L   ++Q +E  L
Sbjct: 1165 VIVTFQEQGEQ-EYKNCELDKNQRQCVEYAL 1194



 Score =  113 bits (282), Expect = 2e-24
 Identities = 74/294 (25%), Positives = 138/294 (46%), Gaps = 42/294 (14%)

Query: 472  KERRMRFYIRR---------MVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 522
            K R +R YI +         +V +  F + +  L+ LNT+C+A+ HY Q       +   
Sbjct: 1195 KARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNIL 1254

Query: 523  EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKP--------- 573
              +F GLF  EM +K+     + YF  ++N FD  +++GSI ++    + P         
Sbjct: 1255 NMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPS 1314

Query: 574  -----GTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
                  +   I+  R  R++R+ K+      +R L+ + + S +++  +  L+ +   ++
Sbjct: 1315 MNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIY 1374

Query: 629  ALLGMQLFG--GQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMY----------- 675
            A++GMQ+FG     +  E     NF TFP A++ +F+  TGE W ++M            
Sbjct: 1375 AVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPE 1434

Query: 676  --DGIKSQGGVQGGMVFSI-YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
                  ++G    G  F++ YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1435 SEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 79/311 (25%), Positives = 143/311 (45%), Gaps = 41/311 (13%)

Query: 1234 RRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMV 1293
            RR C   +    F   ++ ++ ++++ +A+E   QPN     V    +     +FT EM+
Sbjct: 514  RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW-LTEVQDTANKALLALFTAEML 572

Query: 1294 IKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRP 1353
            +KM  LGL     AYF  L+N  D  VV G ++            +  I  LR +R+LR 
Sbjct: 573  LKMYSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLG-ISVLRCVRLLRI 627

Query: 1354 LKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEF 1413
             K  +    L  +   ++NS++++ ++L++  LF+ IF+++ +QLF GKF          
Sbjct: 628  FKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF---------- 677

Query: 1414 EKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDAT 1473
                         +E++ R          +DN   +LLT+F + TGE W  V+    D  
Sbjct: 678  -----------NFDEMQTRRST-------FDNFPQSLLTVFQILTGEDWNSVM---YDGI 716

Query: 1474 FENQGPS-PGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNER 1532
                GPS PG  M + I++++ F+   +  +N+F+A+ +    +  + +      E+ E+
Sbjct: 717  MAYGGPSFPG--MLVCIYFIILFICGNYILLNVFLAIAVDNLAD-AESLTSAQKEEEEEK 773

Query: 1533 ACIDFAISAKP 1543
                 A +A P
Sbjct: 774  ERKKLARTASP 784



 Score = 82.0 bits (201), Expect = 6e-15
 Identities = 73/297 (24%), Positives = 130/297 (43%), Gaps = 62/297 (20%)

Query: 1567 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1623
            PFE  I+  I  N + L +        S A  + L     +F  +F++E  LKV+A+G+L
Sbjct: 125  PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1624 ----NYFRDAWNIFDFVTVLGSITDILVTEF----GNNFI-------NLSFLRLFRAARL 1668
                 Y R+ WN+ DF+ V+  +   ++ +     G N +       ++  LR FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1669 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF---------GNIGI 1719
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F            GI
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1720 -DVEDEDSDEDEFQITEH---------------------NNFRTFFQALMLLFRSATGEA 1757
             DV  ED        T H                      NF  F  A++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1758 WHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
            W +++               +    G ++ + YFV+ I + SF +LNL + V+   F
Sbjct: 365  WTDVLY-------------WVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 69/302 (22%), Positives = 118/302 (39%), Gaps = 81/302 (26%)

Query: 100  FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
            FEY++   I+ N I LA++ +            ++     F G+F  E  +K+IA    F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273

Query: 160  HKGSYLRNGWNVMDFVVVLTGILATVGTEFD--------------------LRTLRAVRV 199
                Y  + WN  D ++V+  I+    TE +                    +   R  RV
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333

Query: 200  LRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEE 259
            +R +KL+S    ++ +L + +K+   L  + LL+     I+A+IG++ + GK        
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI------- 1385

Query: 260  GTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEG 319
                      A   T E  R               NN    F     AVL +F+C T E 
Sbjct: 1386 ----------ALNDTTEINR---------------NNNFQTFPQ---AVLLLFRCATGEA 1417

Query: 320  WTDLLY---------------NSNDAS---GNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
            W D++                NS +     G+++   YFI   ++ +F ++NL + V+  
Sbjct: 1418 WQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMD 1477

Query: 362  EF 363
             F
Sbjct: 1478 NF 1479


>gi|193788542 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 17 [Homo sapiens]
          Length = 2138

 Score =  775 bits (2000), Expect = 0.0
 Identities = 407/869 (46%), Positives = 564/869 (64%), Gaps = 56/869 (6%)

Query: 1146 IVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEE 1205
            +V  P+  ++   K   K      + PPA    +N   +Q N+N +  P P  E   +E+
Sbjct: 790  LVEKPAVGESKEEKIELKSITADGESPPATK--INMDDLQPNENEDKSPYPNPETTGEED 847

Query: 1206 EEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLCHYILNLRYFEMCIL 1251
            EE+     GP+P              MP  S+ FI S+ N  R  CH I+N   F   IL
Sbjct: 848  EEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLIL 907

Query: 1252 MVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRD 1311
              I +SSI+LAAEDPVQ  + RN++L   DYVFT +FT E+++KM   G  LH+G++ R+
Sbjct: 908  FFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRN 967

Query: 1312 LWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVV 1371
             +NILD +VVS +L++F    ++    IN +K LRVLRVLRPL+ I R   LK V  CV 
Sbjct: 968  YFNILDLLVVSVSLISFGIQSSA----INVVKILRVLRVLRPLRAINRAKGLKHVVQCVF 1023

Query: 1372 NSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK- 1430
             +++ + NI+IV  L  F+FA + VQLFKGK + C+D SK+ E +C+G Y+ Y+  EV  
Sbjct: 1024 VAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDH 1083

Query: 1431 --ARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMS 1488
               + R W+  +F +DNVL A++ LFTVST EGWP++L  S+D+  E++GP   YR+E+S
Sbjct: 1084 PIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEIS 1143

Query: 1489 IFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHM 1548
            IF+++Y ++  FF +NIFV  +I+TFQEQG++  +   L+KN+R C+++A+ A+PL R++
Sbjct: 1144 IFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYI 1203

Query: 1549 PQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSL 1608
            P+N+   QY++W  V S  FEY +  +I LNTI L M+ YG S  ++ A+ + N++FT L
Sbjct: 1204 PKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGL 1261

Query: 1609 FSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFG---------------NN 1653
            F++E +LK++AF   +YF DAWN FD + V+GSI DI +TE                 N+
Sbjct: 1262 FTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENS 1321

Query: 1654 FINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQV 1713
             I+++F RLFR  RL+KLL +G  IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQV
Sbjct: 1322 RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV 1381

Query: 1714 FGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPC-- 1771
            FG I ++        D  +I  +NNF+TF QA++LLFR ATGEAW +IML+C+ GK C  
Sbjct: 1382 FGKIALN--------DTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAP 1433

Query: 1772 ---DKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHH 1828
                 NS      CG+ FA FYF+SF  LC+FL++NLFVAVIMDNF+YLTRD SILGPHH
Sbjct: 1434 ESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHH 1493

Query: 1829 LDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADD 1888
            LDE+ R+WAEYDP A GRI + D+ +LLR I PPLG GK CPHRVACKRL+ M++P+  D
Sbjct: 1494 LDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSD 1553

Query: 1889 NTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKS 1948
             TV FN+TL AL+RTAL IK      + +Q + ELR  +  IW   S K LD +V P   
Sbjct: 1554 GTVMFNATLFALVRTALRIKTE---GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGD 1610

Query: 1949 TDLTVGKIYAAMMIMEYYRQSKAKKLQAM 1977
             ++TVGK YA  +I EY+R+ K +K Q +
Sbjct: 1611 DEVTVGKFYATFLIQEYFRKFKKRKEQGL 1639



 Score =  671 bits (1730), Expect = 0.0
 Identities = 383/827 (46%), Positives = 507/827 (61%), Gaps = 64/827 (7%)

Query: 2   ARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQG-----------GQPGAQRMYKQ 50
           + +G   PA +    + AAAG+        GA  S Q            G  G   +   
Sbjct: 18  SNYGSPRPA-HANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTV 76

Query: 51  SMAQRARTMALYNPIPVRQNCLTVNR---SLFLFSEDNVVRKYAKKITEWPPFEYMILAT 107
           S  QR R    Y   P +Q   T  R   +L   +  N +R+    I EW PFE +IL T
Sbjct: 77  SSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLT 133

Query: 108 IIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRN 167
           I ANC+ LA+    P+DD    +  L+  E  F+ IF  EA +K+IA G  FH  +YLRN
Sbjct: 134 IFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRN 193

Query: 168 GWNVMDFVVVLTGILATV----------------GTEFDLRTLRAVRVLRPLKLVSGIPS 211
           GWN++DF++V+ G+ + +                G  FD++ LRA RVLRPL+LVSG+PS
Sbjct: 194 GWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPS 253

Query: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF-EEGTDDIQGES-P 269
           LQVVL SI+KAM+PLL I LL+ F I+I+AIIGLE +MGK H TC+ +EG  D+  E  P
Sbjct: 254 LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 270 APCGTEEP-ARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSN 328
           +PC  E    R C NGT C+P W+GP +GIT FDN  FA+LTVFQCITMEGWTD+LY  N
Sbjct: 314 SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 329 DASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 388
           DA G  W W+YF+ LIIIGSFF+LNLVLGVLSGEF+KERE+ + R  F KLR +QQ+E +
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433

Query: 389 LNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIAS 448
           L GY++WI++AE++    ++   ++  P     R  ++  S+T+ +N E       +  +
Sbjct: 434 LKGYLDWITQAEDIDPENEDEGMDEEKP-----RNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 449 VGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH 508
            G   AR + + +K + S ++ +  R  R   R  VK+  FYW V+ LV LNTL +A  H
Sbjct: 489 CG---ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEH 545

Query: 509 YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIW 568
           YNQP WL++    A    L LF +EM +KMY LG + YF S FN FDC V+ G I E I 
Sbjct: 546 YNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETIL 605

Query: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
              K  +  GISVLR +RLLRIFK+T+YW SL NLV SLLNS++SI SLL LLFLFI++F
Sbjct: 606 VETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIF 665

Query: 629 ALLGMQLFGGQFNFDE-GTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQ-G 686
           +LLGMQLFGG+FNFDE  T  + FD FP +++TVFQILTGEDWN VMYDGI + GG    
Sbjct: 666 SLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 687 GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEV 746
           GM+  IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EEEE   +K         
Sbjct: 726 GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERK--------- 776

Query: 747 AEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREA 793
                   A  +   K+Q+  +KPA  V E +  ++  +++ A  E+
Sbjct: 777 ------KLARTASPEKKQELVEKPA--VGESKEEKIELKSITADGES 815



 Score =  202 bits (513), Expect = 4e-51
 Identities = 176/705 (24%), Positives = 317/705 (44%), Gaps = 120/705 (17%)

Query: 1200 EEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSI 1259
            + K+++    + +       P  ++  L+  NP+RR C  I+  + FE+ IL+ I  + +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1260 ALAAEDPV---QPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNIL 1316
            ALA   P      NA  +N+ R  +Y+F  +FT E  +K+I  GL+ H  AY R+ WN+L
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV-EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198

Query: 1317 DFIVVSGALVAFAFTGNSKGKDINT---------IKSLRVLRVLRPLKTIKRLPKLKAVF 1367
            DFI+V   L +      +K    N          +K+LR  RVLRPL+ +  +P L+ V 
Sbjct: 199  DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258

Query: 1368 DCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC---------- 1417
            + ++ ++  + +I ++ +  + I+A++ ++LF GK  H T  ++E   D           
Sbjct: 259  NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK-MHKTCYNQEGIADVPAEDDPSPCA 317

Query: 1418 --RGKYLLYEKNEVKARDREWKKYEF-HYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
               G     +   V     +  K+   ++DN  +A+LT+F   T EGW  VL    DA  
Sbjct: 318  LETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAV- 376

Query: 1475 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KMMEEY 1525
                     R    I++V   ++  FF +N+ + ++   F ++       GD  K+ E+ 
Sbjct: 377  --------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428

Query: 1526 SLEKNERACIDFAISA---------------KPLTRHMP--------------------- 1549
             LE++ +  +D+   A               KP    MP                     
Sbjct: 429  QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 1550 ----------QNKQSFQYRMWQ---------FVVSPPFEYTIMAMIALNTIVLMMKFYGA 1590
                      ++K S  +R W           V S  F + ++ ++ LNT+ +  + Y  
Sbjct: 489  CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548

Query: 1591 SVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITD-ILVTE 1649
                       N    +LF+ E +LK+ + G+  YF   +N FD   V G I + ILV  
Sbjct: 549  PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 1650 FGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAII 1709
               + + +S LR  R  R+ K+ R   ++  L+ + + S +++  + LL+ +   I++++
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 1710 GMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGK 1769
            GMQ+FG           + DE Q T  + F  F Q+L+ +F+  TGE W+++M   +   
Sbjct: 669  GMQLFGG--------KFNFDEMQ-TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAY 719

Query: 1770 PCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
                  G+L           YF+  +F+C ++++LN+F+A+ +DN
Sbjct: 720  GGPSFPGML--------VCIYFI-ILFICGNYILLNVFLAIAVDN 755



 Score =  143 bits (360), Expect = 2e-33
 Identities = 179/785 (22%), Positives = 325/785 (41%), Gaps = 161/785 (20%)

Query: 33   AGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAK 92
            AGG  +G   GA+  ++ S ++ +R    +N    R+ C    +S       NV      
Sbjct: 480  AGGDIEGENCGARLAHRISKSKFSRYWRRWNRF-CRRKCRAAVKS-------NV------ 525

Query: 93   KITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKI 152
                   F ++++  +  N + +A E +   +    ++E  D      + +F  E  +K+
Sbjct: 526  -------FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKM 575

Query: 153  IALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------FDLRTLRAVRVLRPLKLV 206
             +LG      +Y  + +N  D  VV  GIL T+  E        +  LR VR+LR  K+ 
Sbjct: 576  YSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKIT 631

Query: 207  SGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQG 266
                SL  ++ S++ ++  +  + LLLF  I+IF+++G++ + GKF+        D++Q 
Sbjct: 632  RYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF-------DEMQT 684

Query: 267  ESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYN 326
                                            + FDN   ++LTVFQ +T E W  ++Y+
Sbjct: 685  RR------------------------------STFDNFPQSLLTVFQILTGEDWNSVMYD 714

Query: 327  SNDASGNT-----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERE 368
               A G          +YFI L I G++ +LN+ L +     A             +E+E
Sbjct: 715  GIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKE 774

Query: 369  RVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIK- 427
            R +  R     ++Q+ +E+   G     SK E++ L     DGE   P    +    ++ 
Sbjct: 775  RKKLARTASPEKKQELVEKPAVGE----SKEEKIELKSITADGES--PPATKINMDDLQP 828

Query: 428  ---KSKTDLLNPEEA--EDQLADIASVGS---PFARASIKSAKL---ENSTFF-HKKERR 475
               + K+   NPE    ED+      VG    P +   +K   +   E S FF      R
Sbjct: 829  NENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNR 888

Query: 476  MRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ-PEWLSDFLYYAEFIFLGLFMSEM 534
             R    R+V    F   +L  + L+++ +A     Q   + +  L  A+++F  +F  E+
Sbjct: 889  FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEI 948

Query: 535  FIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRI 590
             +KM   G       +  + FN  D  V+  S+       I+      + +LR LR+LR 
Sbjct: 949  ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRP 1005

Query: 591  FKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQ-FNFDEGTPPT 649
             +       L+++V  +  ++++I +++ +  L   +FA +G+QLF G+ +   + +  T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 650  -------------------------------NFDTFPAAIMTVFQILTGEDWNEVMYDGI 678
                                           +FD   AA+M +F + T E W E++Y  I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 679  KSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEA 733
             S    +G +       SI+FI+  +   + ++N+F+   +        +T  EQ E+E 
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEY 1177

Query: 734  ANQKL 738
             N +L
Sbjct: 1178 KNCEL 1182



 Score =  116 bits (291), Expect = 2e-25
 Identities = 96/331 (29%), Positives = 163/331 (49%), Gaps = 33/331 (9%)

Query: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
            + F+FS +N  R    +I     F  +IL  I+ + I LA E   P    +  +  L + 
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILGNA 936

Query: 137  EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV   ++ + G +      ++
Sbjct: 937  DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLI-SFGIQSSAINVVK 995

Query: 193  TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      +FA IG++ + GK 
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 253  HTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----WEGPNNGITQFDNILFA 307
            +T        D   ++ A C  +    T  +G    P      WE   N    FDN+L A
Sbjct: 1056 YT------CSDSSKQTEAEC--KGNYITYKDGEVDHPIIQPRSWE---NSKFDFDNVLAA 1104

Query: 308  VLTVFQCITMEGWTDLLYNSNDA----SGNTWNW-----LYFIPLIIIGSFFMLNLVLGV 358
            ++ +F   T EGW +LLY S D+     G  +N+     ++FI  III +FFM+N+ +G 
Sbjct: 1105 MMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGF 1164

Query: 359  LSGEFAKERERVENRRAFLKLRRQQQIEREL 389
            +   F ++ E+ E +   L   ++Q +E  L
Sbjct: 1165 VIVTFQEQGEQ-EYKNCELDKNQRQCVEYAL 1194



 Score =  113 bits (282), Expect = 2e-24
 Identities = 74/294 (25%), Positives = 138/294 (46%), Gaps = 42/294 (14%)

Query: 472  KERRMRFYIRR---------MVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 522
            K R +R YI +         +V +  F + +  L+ LNT+C+A+ HY Q       +   
Sbjct: 1195 KARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNIL 1254

Query: 523  EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKP--------- 573
              +F GLF  EM +K+     + YF  ++N FD  +++GSI ++    + P         
Sbjct: 1255 NMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPS 1314

Query: 574  -----GTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
                  +   I+  R  R++R+ K+      +R L+ + + S +++  +  L+ +   ++
Sbjct: 1315 MNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIY 1374

Query: 629  ALLGMQLFG--GQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMY----------- 675
            A++GMQ+FG     +  E     NF TFP A++ +F+  TGE W ++M            
Sbjct: 1375 AVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPE 1434

Query: 676  --DGIKSQGGVQGGMVFSI-YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
                  ++G    G  F++ YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1435 SEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 79/311 (25%), Positives = 143/311 (45%), Gaps = 41/311 (13%)

Query: 1234 RRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMV 1293
            RR C   +    F   ++ ++ ++++ +A+E   QPN     V    +     +FT EM+
Sbjct: 514  RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW-LTEVQDTANKALLALFTAEML 572

Query: 1294 IKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRP 1353
            +KM  LGL     AYF  L+N  D  VV G ++            +  I  LR +R+LR 
Sbjct: 573  LKMYSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLG-ISVLRCVRLLRI 627

Query: 1354 LKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEF 1413
             K  +    L  +   ++NS++++ ++L++  LF+ IF+++ +QLF GKF          
Sbjct: 628  FKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF---------- 677

Query: 1414 EKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDAT 1473
                         +E++ R          +DN   +LLT+F + TGE W  V+    D  
Sbjct: 678  -----------NFDEMQTRRST-------FDNFPQSLLTVFQILTGEDWNSVM---YDGI 716

Query: 1474 FENQGPS-PGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNER 1532
                GPS PG  M + I++++ F+   +  +N+F+A+ +    +  + +      E+ E+
Sbjct: 717  MAYGGPSFPG--MLVCIYFIILFICGNYILLNVFLAIAVDNLAD-AESLTSAQKEEEEEK 773

Query: 1533 ACIDFAISAKP 1543
                 A +A P
Sbjct: 774  ERKKLARTASP 784



 Score = 82.0 bits (201), Expect = 6e-15
 Identities = 73/297 (24%), Positives = 130/297 (43%), Gaps = 62/297 (20%)

Query: 1567 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1623
            PFE  I+  I  N + L +        S A  + L     +F  +F++E  LKV+A+G+L
Sbjct: 125  PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1624 ----NYFRDAWNIFDFVTVLGSITDILVTEF----GNNFI-------NLSFLRLFRAARL 1668
                 Y R+ WN+ DF+ V+  +   ++ +     G N +       ++  LR FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1669 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF---------GNIGI 1719
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F            GI
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1720 -DVEDEDSDEDEFQITEH---------------------NNFRTFFQALMLLFRSATGEA 1757
             DV  ED        T H                      NF  F  A++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1758 WHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
            W +++               +    G ++ + YFV+ I + SF +LNL + V+   F
Sbjct: 365  WTDVLY-------------WVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 69/302 (22%), Positives = 118/302 (39%), Gaps = 81/302 (26%)

Query: 100  FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
            FEY++   I+ N I LA++ +            ++     F G+F  E  +K+IA    F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273

Query: 160  HKGSYLRNGWNVMDFVVVLTGILATVGTEFD--------------------LRTLRAVRV 199
                Y  + WN  D ++V+  I+    TE +                    +   R  RV
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333

Query: 200  LRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEE 259
            +R +KL+S    ++ +L + +K+   L  + LL+     I+A+IG++ + GK        
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI------- 1385

Query: 260  GTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEG 319
                      A   T E  R               NN    F     AVL +F+C T E 
Sbjct: 1386 ----------ALNDTTEINR---------------NNNFQTFPQ---AVLLLFRCATGEA 1417

Query: 320  WTDLLY---------------NSNDAS---GNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
            W D++                NS +     G+++   YFI   ++ +F ++NL + V+  
Sbjct: 1418 WQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMD 1477

Query: 362  EF 363
             F
Sbjct: 1478 NF 1479


>gi|193788536 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 14 [Homo sapiens]
          Length = 2138

 Score =  775 bits (2000), Expect = 0.0
 Identities = 407/869 (46%), Positives = 564/869 (64%), Gaps = 56/869 (6%)

Query: 1146 IVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEE 1205
            +V  P+  ++   K   K      + PPA    +N   +Q N+N +  P P  E   +E+
Sbjct: 790  LVEKPAVGESKEEKIELKSITADGESPPATK--INMDDLQPNENEDKSPYPNPETTGEED 847

Query: 1206 EEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLCHYILNLRYFEMCIL 1251
            EE+     GP+P              MP  S+ FI S+ N  R  CH I+N   F   IL
Sbjct: 848  EEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLIL 907

Query: 1252 MVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRD 1311
              I +SSI+LAAEDPVQ  + RN++L   DYVFT +FT E+++KM   G  LH+G++ R+
Sbjct: 908  FFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRN 967

Query: 1312 LWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVV 1371
             +NILD +VVS +L++F    ++    IN +K LRVLRVLRPL+ I R   LK V  CV 
Sbjct: 968  YFNILDLLVVSVSLISFGIQSSA----INVVKILRVLRVLRPLRAINRAKGLKHVVQCVF 1023

Query: 1372 NSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK- 1430
             +++ + NI+IV  L  F+FA + VQLFKGK + C+D SK+ E +C+G Y+ Y+  EV  
Sbjct: 1024 VAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDH 1083

Query: 1431 --ARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMS 1488
               + R W+  +F +DNVL A++ LFTVST EGWP++L  S+D+  E++GP   YR+E+S
Sbjct: 1084 PIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEIS 1143

Query: 1489 IFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHM 1548
            IF+++Y ++  FF +NIFV  +I+TFQEQG++  +   L+KN+R C+++A+ A+PL R++
Sbjct: 1144 IFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYI 1203

Query: 1549 PQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSL 1608
            P+N+   QY++W  V S  FEY +  +I LNTI L M+ YG S  ++ A+ + N++FT L
Sbjct: 1204 PKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGL 1261

Query: 1609 FSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFG---------------NN 1653
            F++E +LK++AF   +YF DAWN FD + V+GSI DI +TE                 N+
Sbjct: 1262 FTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENS 1321

Query: 1654 FINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQV 1713
             I+++F RLFR  RL+KLL +G  IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQV
Sbjct: 1322 RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV 1381

Query: 1714 FGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPC-- 1771
            FG I ++        D  +I  +NNF+TF QA++LLFR ATGEAW +IML+C+ GK C  
Sbjct: 1382 FGKIALN--------DTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAP 1433

Query: 1772 ---DKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHH 1828
                 NS      CG+ FA FYF+SF  LC+FL++NLFVAVIMDNF+YLTRD SILGPHH
Sbjct: 1434 ESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHH 1493

Query: 1829 LDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADD 1888
            LDE+ R+WAEYDP A GRI + D+ +LLR I PPLG GK CPHRVACKRL+ M++P+  D
Sbjct: 1494 LDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSD 1553

Query: 1889 NTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKS 1948
             TV FN+TL AL+RTAL IK      + +Q + ELR  +  IW   S K LD +V P   
Sbjct: 1554 GTVMFNATLFALVRTALRIKTE---GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGD 1610

Query: 1949 TDLTVGKIYAAMMIMEYYRQSKAKKLQAM 1977
             ++TVGK YA  +I EY+R+ K +K Q +
Sbjct: 1611 DEVTVGKFYATFLIQEYFRKFKKRKEQGL 1639



 Score =  661 bits (1705), Expect = 0.0
 Identities = 379/827 (45%), Positives = 504/827 (60%), Gaps = 64/827 (7%)

Query: 2   ARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQG-----------GQPGAQRMYKQ 50
           + +G   PA +    + AAAG+        GA  S Q            G  G   +   
Sbjct: 18  SNYGSPRPA-HANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTV 76

Query: 51  SMAQRARTMALYNPIPVRQNCLTVNR---SLFLFSEDNVVRKYAKKITEWPPFEYMILAT 107
           S  QR R    Y   P +Q   T  R   +L   +  N +R+    I EW PFE +IL T
Sbjct: 77  SSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLT 133

Query: 108 IIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRN 167
           I ANC+ LA+    P+DD    +  L+  E  F+ IF  EA +K+IA G  FH  +YLRN
Sbjct: 134 IFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRN 193

Query: 168 GWNVMDFVVVLTGILATV----------------GTEFDLRTLRAVRVLRPLKLVSGIPS 211
           GWN++DF++V+ G+ + +                G  FD++ LRA RVLRPL+LVSG+PS
Sbjct: 194 GWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPS 253

Query: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF-EEGTDDIQGES-P 269
           LQVVL SI+KAM+PLL I LL+ F I+I+AIIGLE +MGK H TC+ +EG  D+  E  P
Sbjct: 254 LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 270 APCGTEEP-ARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSN 328
           +PC  E    R C NGT C+P W+GP +GIT FDN  FA+LTVFQCITMEGWTD+LY   
Sbjct: 314 SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQ 373

Query: 329 DASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 388
           DA G    W+YF+ L+I GSFF+LNLVLGVLSGEF+KERE+ + R  F KLR +QQ+E +
Sbjct: 374 DAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433

Query: 389 LNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIAS 448
           L GY++WI++AE++    ++   ++  P     R  ++  S+T+ +N E       +  +
Sbjct: 434 LKGYLDWITQAEDIDPENEDEGMDEEKP-----RNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 449 VGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH 508
            G   AR + + +K + S ++ +  R  R   R  VK+  FYW V+ LV LNTL +A  H
Sbjct: 489 CG---ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEH 545

Query: 509 YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIW 568
           YNQP WL++    A    L LF +EM +KMY LG + YF S FN FDC V+ G I E I 
Sbjct: 546 YNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETIL 605

Query: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
              K  +  GISVLR +RLLRIFK+T+YW SL NLV SLLNS++SI SLL LLFLFI++F
Sbjct: 606 VETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIF 665

Query: 629 ALLGMQLFGGQFNFDE-GTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQ-G 686
           +LLGMQLFGG+FNFDE  T  + FD FP +++TVFQILTGEDWN VMYDGI + GG    
Sbjct: 666 SLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 687 GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEV 746
           GM+  IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EEEE   +K         
Sbjct: 726 GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERK--------- 776

Query: 747 AEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREA 793
                   A  +   K+Q+  +KPA  V E +  ++  +++ A  E+
Sbjct: 777 ------KLARTASPEKKQELVEKPA--VGESKEEKIELKSITADGES 815



 Score =  204 bits (520), Expect = 6e-52
 Identities = 181/706 (25%), Positives = 319/706 (45%), Gaps = 122/706 (17%)

Query: 1200 EEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSI 1259
            + K+++    + +       P  ++  L+  NP+RR C  I+  + FE+ IL+ I  + +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1260 ALAAEDPV---QPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNIL 1316
            ALA   P      NA  +N+ R  +Y+F  +FT E  +K+I  GL+ H  AY R+ WN+L
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV-EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198

Query: 1317 DFIVVSGALVAFAFTGNSKGKDINT---------IKSLRVLRVLRPLKTIKRLPKLKAVF 1367
            DFI+V   L +      +K    N          +K+LR  RVLRPL+ +  +P L+ V 
Sbjct: 199  DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258

Query: 1368 DCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC---------- 1417
            + ++ ++  + +I ++ +  + I+A++ ++LF GK  H T  ++E   D           
Sbjct: 259  NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK-MHKTCYNQEGIADVPAEDDPSPCA 317

Query: 1418 --RGKYLLYEKNEVKARDREWKKYEF-HYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
               G     +   V     +  K+   ++DN  +A+LT+F   T EGW  VL    DA  
Sbjct: 318  LETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAM- 376

Query: 1475 ENQGPSPGYRMEMSIFYVVYFVVFPFFFV-NIFVALIIITFQEQ-------GD--KMMEE 1524
                   GY  E+   Y V  V+F  FFV N+ + ++   F ++       GD  K+ E+
Sbjct: 377  -------GY--ELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREK 427

Query: 1525 YSLEKNERACIDFAISA---------------KPLTRHMP-------------------- 1549
              LE++ +  +D+   A               KP    MP                    
Sbjct: 428  QQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGE 487

Query: 1550 -----------QNKQSFQYRMWQ---------FVVSPPFEYTIMAMIALNTIVLMMKFYG 1589
                       ++K S  +R W           V S  F + ++ ++ LNT+ +  + Y 
Sbjct: 488  NCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYN 547

Query: 1590 ASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITD-ILVT 1648
                        N    +LF+ E +LK+ + G+  YF   +N FD   V G I + ILV 
Sbjct: 548  QPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVE 607

Query: 1649 EFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAI 1708
                + + +S LR  R  R+ K+ R   ++  L+ + + S +++  + LL+ +   I+++
Sbjct: 608  TKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSL 667

Query: 1709 IGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSG 1768
            +GMQ+FG           + DE Q T  + F  F Q+L+ +F+  TGE W+++M   +  
Sbjct: 668  LGMQLFGG--------KFNFDEMQ-TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMA 718

Query: 1769 KPCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
                   G+L           YF+  +F+C ++++LN+F+A+ +DN
Sbjct: 719  YGGPSFPGML--------VCIYFI-ILFICGNYILLNVFLAIAVDN 755



 Score =  143 bits (360), Expect = 2e-33
 Identities = 179/785 (22%), Positives = 325/785 (41%), Gaps = 161/785 (20%)

Query: 33   AGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAK 92
            AGG  +G   GA+  ++ S ++ +R    +N    R+ C    +S       NV      
Sbjct: 480  AGGDIEGENCGARLAHRISKSKFSRYWRRWNRF-CRRKCRAAVKS-------NV------ 525

Query: 93   KITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKI 152
                   F ++++  +  N + +A E +   +    ++E  D      + +F  E  +K+
Sbjct: 526  -------FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKM 575

Query: 153  IALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------FDLRTLRAVRVLRPLKLV 206
             +LG      +Y  + +N  D  VV  GIL T+  E        +  LR VR+LR  K+ 
Sbjct: 576  YSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKIT 631

Query: 207  SGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQG 266
                SL  ++ S++ ++  +  + LLLF  I+IF+++G++ + GKF+        D++Q 
Sbjct: 632  RYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF-------DEMQT 684

Query: 267  ESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYN 326
                                            + FDN   ++LTVFQ +T E W  ++Y+
Sbjct: 685  RR------------------------------STFDNFPQSLLTVFQILTGEDWNSVMYD 714

Query: 327  SNDASGNT-----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERE 368
               A G          +YFI L I G++ +LN+ L +     A             +E+E
Sbjct: 715  GIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKE 774

Query: 369  RVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIK- 427
            R +  R     ++Q+ +E+   G     SK E++ L     DGE   P    +    ++ 
Sbjct: 775  RKKLARTASPEKKQELVEKPAVGE----SKEEKIELKSITADGES--PPATKINMDDLQP 828

Query: 428  ---KSKTDLLNPEEA--EDQLADIASVGS---PFARASIKSAKL---ENSTFF-HKKERR 475
               + K+   NPE    ED+      VG    P +   +K   +   E S FF      R
Sbjct: 829  NENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNR 888

Query: 476  MRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ-PEWLSDFLYYAEFIFLGLFMSEM 534
             R    R+V    F   +L  + L+++ +A     Q   + +  L  A+++F  +F  E+
Sbjct: 889  FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEI 948

Query: 535  FIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRI 590
             +KM   G       +  + FN  D  V+  S+       I+      + +LR LR+LR 
Sbjct: 949  ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRP 1005

Query: 591  FKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQ-FNFDEGTPPT 649
             +       L+++V  +  ++++I +++ +  L   +FA +G+QLF G+ +   + +  T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 650  -------------------------------NFDTFPAAIMTVFQILTGEDWNEVMYDGI 678
                                           +FD   AA+M +F + T E W E++Y  I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 679  KSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEA 733
             S    +G +       SI+FI+  +   + ++N+F+   +        +T  EQ E+E 
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEY 1177

Query: 734  ANQKL 738
             N +L
Sbjct: 1178 KNCEL 1182



 Score =  116 bits (291), Expect = 2e-25
 Identities = 96/331 (29%), Positives = 163/331 (49%), Gaps = 33/331 (9%)

Query: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
            + F+FS +N  R    +I     F  +IL  I+ + I LA E   P    +  +  L + 
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILGNA 936

Query: 137  EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV   ++ + G +      ++
Sbjct: 937  DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLI-SFGIQSSAINVVK 995

Query: 193  TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      +FA IG++ + GK 
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 253  HTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----WEGPNNGITQFDNILFA 307
            +T        D   ++ A C  +    T  +G    P      WE   N    FDN+L A
Sbjct: 1056 YT------CSDSSKQTEAEC--KGNYITYKDGEVDHPIIQPRSWE---NSKFDFDNVLAA 1104

Query: 308  VLTVFQCITMEGWTDLLYNSNDA----SGNTWNW-----LYFIPLIIIGSFFMLNLVLGV 358
            ++ +F   T EGW +LLY S D+     G  +N+     ++FI  III +FFM+N+ +G 
Sbjct: 1105 MMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGF 1164

Query: 359  LSGEFAKERERVENRRAFLKLRRQQQIEREL 389
            +   F ++ E+ E +   L   ++Q +E  L
Sbjct: 1165 VIVTFQEQGEQ-EYKNCELDKNQRQCVEYAL 1194



 Score =  113 bits (282), Expect = 2e-24
 Identities = 74/294 (25%), Positives = 138/294 (46%), Gaps = 42/294 (14%)

Query: 472  KERRMRFYIRR---------MVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 522
            K R +R YI +         +V +  F + +  L+ LNT+C+A+ HY Q       +   
Sbjct: 1195 KARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNIL 1254

Query: 523  EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKP--------- 573
              +F GLF  EM +K+     + YF  ++N FD  +++GSI ++    + P         
Sbjct: 1255 NMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPS 1314

Query: 574  -----GTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
                  +   I+  R  R++R+ K+      +R L+ + + S +++  +  L+ +   ++
Sbjct: 1315 MNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIY 1374

Query: 629  ALLGMQLFG--GQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMY----------- 675
            A++GMQ+FG     +  E     NF TFP A++ +F+  TGE W ++M            
Sbjct: 1375 AVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPE 1434

Query: 676  --DGIKSQGGVQGGMVFSI-YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
                  ++G    G  F++ YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1435 SEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 79/311 (25%), Positives = 143/311 (45%), Gaps = 41/311 (13%)

Query: 1234 RRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMV 1293
            RR C   +    F   ++ ++ ++++ +A+E   QPN     V    +     +FT EM+
Sbjct: 514  RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW-LTEVQDTANKALLALFTAEML 572

Query: 1294 IKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRP 1353
            +KM  LGL     AYF  L+N  D  VV G ++            +  I  LR +R+LR 
Sbjct: 573  LKMYSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLG-ISVLRCVRLLRI 627

Query: 1354 LKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEF 1413
             K  +    L  +   ++NS++++ ++L++  LF+ IF+++ +QLF GKF          
Sbjct: 628  FKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF---------- 677

Query: 1414 EKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDAT 1473
                         +E++ R          +DN   +LLT+F + TGE W  V+    D  
Sbjct: 678  -----------NFDEMQTRRST-------FDNFPQSLLTVFQILTGEDWNSVM---YDGI 716

Query: 1474 FENQGPS-PGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNER 1532
                GPS PG  M + I++++ F+   +  +N+F+A+ +    +  + +      E+ E+
Sbjct: 717  MAYGGPSFPG--MLVCIYFIILFICGNYILLNVFLAIAVDNLAD-AESLTSAQKEEEEEK 773

Query: 1533 ACIDFAISAKP 1543
                 A +A P
Sbjct: 774  ERKKLARTASP 784



 Score = 81.6 bits (200), Expect = 8e-15
 Identities = 74/297 (24%), Positives = 128/297 (43%), Gaps = 62/297 (20%)

Query: 1567 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1623
            PFE  I+  I  N + L +        S A  + L     +F  +F++E  LKV+A+G+L
Sbjct: 125  PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1624 ----NYFRDAWNIFDFVTVLGSITDILVTEF----GNNFI-------NLSFLRLFRAARL 1668
                 Y R+ WN+ DF+ V+  +   ++ +     G N +       ++  LR FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1669 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF---------GNIGI 1719
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F            GI
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1720 -DVEDEDSDEDEFQITEH---------------------NNFRTFFQALMLLFRSATGEA 1757
             DV  ED        T H                      NF  F  A++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1758 WHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
            W +++               +    G E  + YFVS +   SF +LNL + V+   F
Sbjct: 365  WTDVLY-------------WMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 408



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 69/302 (22%), Positives = 118/302 (39%), Gaps = 81/302 (26%)

Query: 100  FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
            FEY++   I+ N I LA++ +            ++     F G+F  E  +K+IA    F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273

Query: 160  HKGSYLRNGWNVMDFVVVLTGILATVGTEFD--------------------LRTLRAVRV 199
                Y  + WN  D ++V+  I+    TE +                    +   R  RV
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333

Query: 200  LRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEE 259
            +R +KL+S    ++ +L + +K+   L  + LL+     I+A+IG++ + GK        
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI------- 1385

Query: 260  GTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEG 319
                      A   T E  R               NN    F     AVL +F+C T E 
Sbjct: 1386 ----------ALNDTTEINR---------------NNNFQTFPQ---AVLLLFRCATGEA 1417

Query: 320  WTDLLY---------------NSNDAS---GNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
            W D++                NS +     G+++   YFI   ++ +F ++NL + V+  
Sbjct: 1418 WQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMD 1477

Query: 362  EF 363
             F
Sbjct: 1478 NF 1479


>gi|193788528 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 8 [Homo sapiens]
          Length = 2157

 Score =  774 bits (1998), Expect = 0.0
 Identities = 411/885 (46%), Positives = 568/885 (64%), Gaps = 69/885 (7%)

Query: 1146 IVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEE 1205
            +V  P+  ++   K   K      + PPA    +N   +Q N+N +  P P  E   +E+
Sbjct: 790  LVEKPAVGESKEEKIELKSITADGESPPATK--INMDDLQPNENEDKSPYPNPETTGEED 847

Query: 1206 EEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLCHYILNLRYFEMCIL 1251
            EE+     GP+P              MP  S+ FI S+ N  R  CH I+N   F   IL
Sbjct: 848  EEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLIL 907

Query: 1252 MVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRD 1311
              I +SSI+LAAEDPVQ  + RN++L YFD VFT +FT E+ +KM   G  LH+G++ R+
Sbjct: 908  FFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRN 967

Query: 1312 LWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVV 1371
             +NILD +VVS +L++F    ++    IN +K LRVLRVLRPL+ I R   LK V  CV 
Sbjct: 968  YFNILDLLVVSVSLISFGIQSSA----INVVKILRVLRVLRPLRAINRAKGLKHVVQCVF 1023

Query: 1372 NSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK- 1430
             +++ + NI+IV  L  F+FA + VQLFKGK + C+D SK+ E +C+G Y+ Y+  EV  
Sbjct: 1024 VAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDH 1083

Query: 1431 --ARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMS 1488
               + R W+  +F +DNVL A++ LFTVST EGWP++L  S+D+  E++GP   YR+E+S
Sbjct: 1084 PIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEIS 1143

Query: 1489 IFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHM 1548
            IF+++Y ++  FF +NIFV  +I+TFQEQG++  +   L+KN+R C+++A+ A+PL R++
Sbjct: 1144 IFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYI 1203

Query: 1549 PQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSL 1608
            P+N+   QY++W  V S  FEY +  +I LNTI L M+ YG S  ++ A+ + N++FT L
Sbjct: 1204 PKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGL 1261

Query: 1609 FSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFG---------------NN 1653
            F++E +LK++AF   +YF DAWN FD + V+GSI DI +TE                 N+
Sbjct: 1262 FTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENS 1321

Query: 1654 FINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQV 1713
             I+++F RLFR  RL+KLL +G  IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQV
Sbjct: 1322 RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV 1381

Query: 1714 FGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPC-- 1771
            FG I ++        D  +I  +NNF+TF QA++LLFR ATGEAW +IML+C+ GK C  
Sbjct: 1382 FGKIALN--------DTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAP 1433

Query: 1772 ---DKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHH 1828
                 NS      CG+ FA FYF+SF  LC+FL++NLFVAVIMDNF+YLTRD SILGPHH
Sbjct: 1434 ESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHH 1493

Query: 1829 LDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADD 1888
            LDE+ R+WAEYDP A GRI + D+ +LLR I PPLG GK CPHRVACKRL+ M++P+  D
Sbjct: 1494 LDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSD 1553

Query: 1889 NTVHFNSTLMALIRTALDIKIAKG--------GADK--------QQMDAELRKEMMAIWP 1932
             TV FN+TL AL+RTAL IK  +G        GA+         +Q + ELR  +  IW 
Sbjct: 1554 GTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWK 1613

Query: 1933 NLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAM 1977
              S K LD +V P    ++TVGK YA  +I EY+R+ K +K Q +
Sbjct: 1614 RTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGL 1658



 Score =  671 bits (1730), Expect = 0.0
 Identities = 383/827 (46%), Positives = 507/827 (61%), Gaps = 64/827 (7%)

Query: 2   ARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQG-----------GQPGAQRMYKQ 50
           + +G   PA +    + AAAG+        GA  S Q            G  G   +   
Sbjct: 18  SNYGSPRPA-HANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTV 76

Query: 51  SMAQRARTMALYNPIPVRQNCLTVNR---SLFLFSEDNVVRKYAKKITEWPPFEYMILAT 107
           S  QR R    Y   P +Q   T  R   +L   +  N +R+    I EW PFE +IL T
Sbjct: 77  SSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLT 133

Query: 108 IIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRN 167
           I ANC+ LA+    P+DD    +  L+  E  F+ IF  EA +K+IA G  FH  +YLRN
Sbjct: 134 IFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRN 193

Query: 168 GWNVMDFVVVLTGILATV----------------GTEFDLRTLRAVRVLRPLKLVSGIPS 211
           GWN++DF++V+ G+ + +                G  FD++ LRA RVLRPL+LVSG+PS
Sbjct: 194 GWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPS 253

Query: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF-EEGTDDIQGES-P 269
           LQVVL SI+KAM+PLL I LL+ F I+I+AIIGLE +MGK H TC+ +EG  D+  E  P
Sbjct: 254 LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 270 APCGTEEP-ARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSN 328
           +PC  E    R C NGT C+P W+GP +GIT FDN  FA+LTVFQCITMEGWTD+LY  N
Sbjct: 314 SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 329 DASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 388
           DA G  W W+YF+ LIIIGSFF+LNLVLGVLSGEF+KERE+ + R  F KLR +QQ+E +
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433

Query: 389 LNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIAS 448
           L GY++WI++AE++    ++   ++  P     R  ++  S+T+ +N E       +  +
Sbjct: 434 LKGYLDWITQAEDIDPENEDEGMDEEKP-----RNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 449 VGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH 508
            G   AR + + +K + S ++ +  R  R   R  VK+  FYW V+ LV LNTL +A  H
Sbjct: 489 CG---ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEH 545

Query: 509 YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIW 568
           YNQP WL++    A    L LF +EM +KMY LG + YF S FN FDC V+ G I E I 
Sbjct: 546 YNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETIL 605

Query: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
              K  +  GISVLR +RLLRIFK+T+YW SL NLV SLLNS++SI SLL LLFLFI++F
Sbjct: 606 VETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIF 665

Query: 629 ALLGMQLFGGQFNFDE-GTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQ-G 686
           +LLGMQLFGG+FNFDE  T  + FD FP +++TVFQILTGEDWN VMYDGI + GG    
Sbjct: 666 SLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 687 GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEV 746
           GM+  IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EEEE   +K         
Sbjct: 726 GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERK--------- 776

Query: 747 AEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREA 793
                   A  +   K+Q+  +KPA  V E +  ++  +++ A  E+
Sbjct: 777 ------KLARTASPEKKQELVEKPA--VGESKEEKIELKSITADGES 815



 Score =  202 bits (513), Expect = 4e-51
 Identities = 176/705 (24%), Positives = 317/705 (44%), Gaps = 120/705 (17%)

Query: 1200 EEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSI 1259
            + K+++    + +       P  ++  L+  NP+RR C  I+  + FE+ IL+ I  + +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1260 ALAAEDPV---QPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNIL 1316
            ALA   P      NA  +N+ R  +Y+F  +FT E  +K+I  GL+ H  AY R+ WN+L
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV-EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198

Query: 1317 DFIVVSGALVAFAFTGNSKGKDINT---------IKSLRVLRVLRPLKTIKRLPKLKAVF 1367
            DFI+V   L +      +K    N          +K+LR  RVLRPL+ +  +P L+ V 
Sbjct: 199  DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258

Query: 1368 DCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC---------- 1417
            + ++ ++  + +I ++ +  + I+A++ ++LF GK  H T  ++E   D           
Sbjct: 259  NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK-MHKTCYNQEGIADVPAEDDPSPCA 317

Query: 1418 --RGKYLLYEKNEVKARDREWKKYEF-HYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
               G     +   V     +  K+   ++DN  +A+LT+F   T EGW  VL    DA  
Sbjct: 318  LETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAV- 376

Query: 1475 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KMMEEY 1525
                     R    I++V   ++  FF +N+ + ++   F ++       GD  K+ E+ 
Sbjct: 377  --------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428

Query: 1526 SLEKNERACIDFAISA---------------KPLTRHMP--------------------- 1549
             LE++ +  +D+   A               KP    MP                     
Sbjct: 429  QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 1550 ----------QNKQSFQYRMWQ---------FVVSPPFEYTIMAMIALNTIVLMMKFYGA 1590
                      ++K S  +R W           V S  F + ++ ++ LNT+ +  + Y  
Sbjct: 489  CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548

Query: 1591 SVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITD-ILVTE 1649
                       N    +LF+ E +LK+ + G+  YF   +N FD   V G I + ILV  
Sbjct: 549  PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 1650 FGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAII 1709
               + + +S LR  R  R+ K+ R   ++  L+ + + S +++  + LL+ +   I++++
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 1710 GMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGK 1769
            GMQ+FG           + DE Q T  + F  F Q+L+ +F+  TGE W+++M   +   
Sbjct: 669  GMQLFGG--------KFNFDEMQ-TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAY 719

Query: 1770 PCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
                  G+L           YF+  +F+C ++++LN+F+A+ +DN
Sbjct: 720  GGPSFPGML--------VCIYFI-ILFICGNYILLNVFLAIAVDN 755



 Score =  144 bits (362), Expect = 1e-33
 Identities = 179/785 (22%), Positives = 325/785 (41%), Gaps = 161/785 (20%)

Query: 33   AGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAK 92
            AGG  +G   GA+  ++ S ++ +R    +N    R+ C    +S       NV      
Sbjct: 480  AGGDIEGENCGARLAHRISKSKFSRYWRRWNRF-CRRKCRAAVKS-------NV------ 525

Query: 93   KITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKI 152
                   F ++++  +  N + +A E +   +    ++E  D      + +F  E  +K+
Sbjct: 526  -------FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKM 575

Query: 153  IALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------FDLRTLRAVRVLRPLKLV 206
             +LG      +Y  + +N  D  VV  GIL T+  E        +  LR VR+LR  K+ 
Sbjct: 576  YSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKIT 631

Query: 207  SGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQG 266
                SL  ++ S++ ++  +  + LLLF  I+IF+++G++ + GKF+        D++Q 
Sbjct: 632  RYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF-------DEMQT 684

Query: 267  ESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYN 326
                                            + FDN   ++LTVFQ +T E W  ++Y+
Sbjct: 685  RR------------------------------STFDNFPQSLLTVFQILTGEDWNSVMYD 714

Query: 327  SNDASGNT-----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERE 368
               A G          +YFI L I G++ +LN+ L +     A             +E+E
Sbjct: 715  GIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKE 774

Query: 369  RVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIK- 427
            R +  R     ++Q+ +E+   G     SK E++ L     DGE   P    +    ++ 
Sbjct: 775  RKKLARTASPEKKQELVEKPAVGE----SKEEKIELKSITADGES--PPATKINMDDLQP 828

Query: 428  ---KSKTDLLNPEEA--EDQLADIASVGS---PFARASIKSAKL---ENSTFF-HKKERR 475
               + K+   NPE    ED+      VG    P +   +K   +   E S FF      R
Sbjct: 829  NENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNR 888

Query: 476  MRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ-PEWLSDFLYYAEFIFLGLFMSEM 534
             R    R+V    F   +L  + L+++ +A     Q   + +  L+Y + +F  +F  E+
Sbjct: 889  FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEI 948

Query: 535  FIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRI 590
             +KM   G       +  + FN  D  V+  S+       I+      + +LR LR+LR 
Sbjct: 949  ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRP 1005

Query: 591  FKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQ-FNFDEGTPPT 649
             +       L+++V  +  ++++I +++ +  L   +FA +G+QLF G+ +   + +  T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 650  -------------------------------NFDTFPAAIMTVFQILTGEDWNEVMYDGI 678
                                           +FD   AA+M +F + T E W E++Y  I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 679  KSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEA 733
             S    +G +       SI+FI+  +   + ++N+F+   +        +T  EQ E+E 
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEY 1177

Query: 734  ANQKL 738
             N +L
Sbjct: 1178 KNCEL 1182



 Score =  114 bits (285), Expect = 1e-24
 Identities = 96/331 (29%), Positives = 162/331 (48%), Gaps = 33/331 (9%)

Query: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
            + F+FS +N  R    +I     F  +IL  I+ + I LA E   P    +  +  L   
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 936

Query: 137  EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV   ++ + G +      ++
Sbjct: 937  DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLI-SFGIQSSAINVVK 995

Query: 193  TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      +FA IG++ + GK 
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 253  HTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----WEGPNNGITQFDNILFA 307
            +T        D   ++ A C  +    T  +G    P      WE   N    FDN+L A
Sbjct: 1056 YT------CSDSSKQTEAEC--KGNYITYKDGEVDHPIIQPRSWE---NSKFDFDNVLAA 1104

Query: 308  VLTVFQCITMEGWTDLLYNSNDA----SGNTWNW-----LYFIPLIIIGSFFMLNLVLGV 358
            ++ +F   T EGW +LLY S D+     G  +N+     ++FI  III +FFM+N+ +G 
Sbjct: 1105 MMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGF 1164

Query: 359  LSGEFAKERERVENRRAFLKLRRQQQIEREL 389
            +   F ++ E+ E +   L   ++Q +E  L
Sbjct: 1165 VIVTFQEQGEQ-EYKNCELDKNQRQCVEYAL 1194



 Score =  113 bits (282), Expect = 2e-24
 Identities = 74/294 (25%), Positives = 138/294 (46%), Gaps = 42/294 (14%)

Query: 472  KERRMRFYIRR---------MVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 522
            K R +R YI +         +V +  F + +  L+ LNT+C+A+ HY Q       +   
Sbjct: 1195 KARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNIL 1254

Query: 523  EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKP--------- 573
              +F GLF  EM +K+     + YF  ++N FD  +++GSI ++    + P         
Sbjct: 1255 NMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPS 1314

Query: 574  -----GTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
                  +   I+  R  R++R+ K+      +R L+ + + S +++  +  L+ +   ++
Sbjct: 1315 MNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIY 1374

Query: 629  ALLGMQLFG--GQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMY----------- 675
            A++GMQ+FG     +  E     NF TFP A++ +F+  TGE W ++M            
Sbjct: 1375 AVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPE 1434

Query: 676  --DGIKSQGGVQGGMVFSI-YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
                  ++G    G  F++ YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1435 SEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 79/311 (25%), Positives = 143/311 (45%), Gaps = 41/311 (13%)

Query: 1234 RRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMV 1293
            RR C   +    F   ++ ++ ++++ +A+E   QPN     V    +     +FT EM+
Sbjct: 514  RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW-LTEVQDTANKALLALFTAEML 572

Query: 1294 IKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRP 1353
            +KM  LGL     AYF  L+N  D  VV G ++            +  I  LR +R+LR 
Sbjct: 573  LKMYSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLG-ISVLRCVRLLRI 627

Query: 1354 LKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEF 1413
             K  +    L  +   ++NS++++ ++L++  LF+ IF+++ +QLF GKF          
Sbjct: 628  FKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF---------- 677

Query: 1414 EKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDAT 1473
                         +E++ R          +DN   +LLT+F + TGE W  V+    D  
Sbjct: 678  -----------NFDEMQTRRST-------FDNFPQSLLTVFQILTGEDWNSVM---YDGI 716

Query: 1474 FENQGPS-PGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNER 1532
                GPS PG  M + I++++ F+   +  +N+F+A+ +    +  + +      E+ E+
Sbjct: 717  MAYGGPSFPG--MLVCIYFIILFICGNYILLNVFLAIAVDNLAD-AESLTSAQKEEEEEK 773

Query: 1533 ACIDFAISAKP 1543
                 A +A P
Sbjct: 774  ERKKLARTASP 784



 Score = 82.0 bits (201), Expect = 6e-15
 Identities = 73/297 (24%), Positives = 130/297 (43%), Gaps = 62/297 (20%)

Query: 1567 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1623
            PFE  I+  I  N + L +        S A  + L     +F  +F++E  LKV+A+G+L
Sbjct: 125  PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1624 ----NYFRDAWNIFDFVTVLGSITDILVTEF----GNNFI-------NLSFLRLFRAARL 1668
                 Y R+ WN+ DF+ V+  +   ++ +     G N +       ++  LR FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1669 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF---------GNIGI 1719
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F            GI
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1720 -DVEDEDSDEDEFQITEH---------------------NNFRTFFQALMLLFRSATGEA 1757
             DV  ED        T H                      NF  F  A++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1758 WHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
            W +++               +    G ++ + YFV+ I + SF +LNL + V+   F
Sbjct: 365  WTDVLY-------------WVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 69/302 (22%), Positives = 118/302 (39%), Gaps = 81/302 (26%)

Query: 100  FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
            FEY++   I+ N I LA++ +            ++     F G+F  E  +K+IA    F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273

Query: 160  HKGSYLRNGWNVMDFVVVLTGILATVGTEFD--------------------LRTLRAVRV 199
                Y  + WN  D ++V+  I+    TE +                    +   R  RV
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333

Query: 200  LRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEE 259
            +R +KL+S    ++ +L + +K+   L  + LL+     I+A+IG++ + GK        
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI------- 1385

Query: 260  GTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEG 319
                      A   T E  R               NN    F     AVL +F+C T E 
Sbjct: 1386 ----------ALNDTTEINR---------------NNNFQTFPQ---AVLLLFRCATGEA 1417

Query: 320  WTDLLY---------------NSNDAS---GNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
            W D++                NS +     G+++   YFI   ++ +F ++NL + V+  
Sbjct: 1418 WQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMD 1477

Query: 362  EF 363
             F
Sbjct: 1478 NF 1479


>gi|192807300 calcium channel, voltage-dependent, L type, alpha 1D
            subunit isoform b [Homo sapiens]
          Length = 2161

 Score =  773 bits (1997), Expect = 0.0
 Identities = 399/825 (48%), Positives = 552/825 (66%), Gaps = 56/825 (6%)

Query: 1192 PDPLPKKEEEKKEEEEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLC 1237
            P  +P  EEE++EEE++     GP+P              +P  S+ FILS TNP+R  C
Sbjct: 820  PCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGC 879

Query: 1238 HYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMI 1297
            H ++N   F   IL+ I +SS ALAAEDP++ ++ RN +L YFDY FT +FT E+++KM 
Sbjct: 880  HKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMT 939

Query: 1298 DLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTI 1357
              G  LH+GA+ R+ +N+LD +VV  +LV+F    ++    I+ +K LRVLRVLRPL+ I
Sbjct: 940  TFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSA----ISVVKILRVLRVLRPLRAI 995

Query: 1358 KRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC 1417
             R   LK V  CV  +++ + NI+IV  L  F+FA + VQLFKGKF+ CTDE+K   ++C
Sbjct: 996  NRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEEC 1055

Query: 1418 RGKYLLYEKNEVKA---RDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
            RG ++LY+  +V +   R+R W+  +F++DNVL A++ LFTVST EGWP +L  ++D+  
Sbjct: 1056 RGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNG 1115

Query: 1475 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERAC 1534
            EN GP   +R+E+SIF+++Y ++  FF +NIFV  +I+TFQEQG+K  +   L+KN+R C
Sbjct: 1116 ENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQC 1175

Query: 1535 IDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAY 1594
            +++A+ A+PL R++P+N   +QY+ W  V S PFEY +  +I LNT+ L M+ Y  S  +
Sbjct: 1176 VEYALKARPLRRYIPKNP--YQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMF 1233

Query: 1595 ENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEF---- 1650
             +A+ + N+VFT +F++E VLKV+AF    YF DAWN FD + V+GSI D+ ++E     
Sbjct: 1234 NDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTE 1293

Query: 1651 -----------GN----NFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1695
                       GN    N I+++F RLFR  RL+KLL +G  IR LLWTF++SF+ALPYV
Sbjct: 1294 SENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYV 1353

Query: 1696 CLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATG 1755
             LLIAMLFFIYA+IGMQ+FG + +         D  QI  +NNF+TF QA++LLFR ATG
Sbjct: 1354 ALLIAMLFFIYAVIGMQMFGKVAM--------RDNNQINRNNNFQTFPQAVLLLFRCATG 1405

Query: 1756 EAWHNIMLSCLSGKPCDKNSGILTRE---CGNEFAYFYFVSFIFLCSFLMLNLFVAVIMD 1812
            EAW  IML+CL GK CD  S     E   CG+ FA  YF+SF  LC+FL++NLFVAVIMD
Sbjct: 1406 EAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMD 1465

Query: 1813 NFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHR 1872
            NF+YLTRD SILGPHHLDE+ R+W+EYDP A GRI + D+ +LLR I PPLG GK CPHR
Sbjct: 1466 NFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHR 1525

Query: 1873 VACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWP 1932
            VACKRL+ M++P+  D TV FN+TL AL+RTAL IK      + +Q + ELR  +  IW 
Sbjct: 1526 VACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE---GNLEQANEELRAVIKKIWK 1582

Query: 1933 NLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAM 1977
              S K LD +V P    ++TVGK YA  +I +Y+R+ K +K Q +
Sbjct: 1583 KTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGL 1627



 Score =  654 bits (1686), Expect = 0.0
 Identities = 354/724 (48%), Positives = 470/724 (64%), Gaps = 39/724 (5%)

Query: 76  RSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDD 135
           R+LF  S +N +R+    I EW PF+  IL  I ANC+ LA+    P+DD    +  L+ 
Sbjct: 104 RALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEK 163

Query: 136 TEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------- 188
            E  F+ IF  E  +KIIA G   H  +Y+RNGWN++DFV+V+ G+ + +  +       
Sbjct: 164 VEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEG 223

Query: 189 ----------FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAIL 238
                     FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAM+PLL I LL+ F I+
Sbjct: 224 GNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 283

Query: 239 IFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCP-NGTKCQPYWEGPNNG 297
           I+AIIGLE ++GK H TCF   +D +  E PAPC      R C  NGT+C+  W GPN G
Sbjct: 284 IYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGG 343

Query: 298 ITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLG 357
           IT FDN  FA+LTVFQCITMEGWTD+LY  NDA G    W+YF+ L+I GSFF+LNLVLG
Sbjct: 344 ITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLG 403

Query: 358 VLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPF 417
           VLSGEF+KERE+ + R  F KLR +QQ+E +L GY++WI++AE++    +E  GE+    
Sbjct: 404 VLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEE---- 459

Query: 418 DGALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMR 477
               R T++  S+T+ +N E    +  +    GS     +I  +KL  S  + +  R  R
Sbjct: 460 --GKRNTSMPTSETESVNTENVSGEGENRGCCGS--LCQAISKSKL--SRRWRRWNRFNR 513

Query: 478 FYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIK 537
              R  VK+  FYW V+ LV LNTL ++  HYNQP+WL+     A  + L LF  EM +K
Sbjct: 514 RRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVK 573

Query: 538 MYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYW 597
           MY LG + YF S FN FDC V+ G I E I   ++  +  GISV R +RLLRIFKVT++W
Sbjct: 574 MYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHW 633

Query: 598 ASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDE-GTPPTNFDTFPA 656
            SL NLV SLLNSMKSI SLL LLFLFI++F+LLGMQLFGG+FNFDE  T  + FD FP 
Sbjct: 634 TSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQ 693

Query: 657 AIMTVFQILTGEDWNEVMYDGIKSQGG-VQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVD 715
           A++TVFQILTGEDWN VMYDGI + GG    GM+  IYFI+L + GNY LLNVFLAIAVD
Sbjct: 694 ALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVD 753

Query: 716 NLANAQEL-TKDEQEEEEAANQKLALQKAKE-----VAEVSPLSAANMSIAV---KEQQK 766
           NLA+A+ L T  ++E EE   +K+A +++ E       EV+ ++ ++  + +   +E+ +
Sbjct: 754 NLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDE 813

Query: 767 NQKP 770
           ++ P
Sbjct: 814 DKDP 817



 Score =  217 bits (552), Expect = 1e-55
 Identities = 180/719 (25%), Positives = 329/719 (45%), Gaps = 121/719 (16%)

Query: 1185 QVNKNANPDPLPKKEEEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLR 1244
            Q    + P P+    + K+++    + +       P  ++F LS  NP+RR C  I+  +
Sbjct: 67   QTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWK 126

Query: 1245 YFEMCILMVIAMSSIALAAEDPVQPNAPR--NNVLRYFDYVFTGVFTFEMVIKMIDLGLV 1302
             F++ IL+ I  + +ALA   P   +     N+ L   +Y F  +FT E  +K+I  GL+
Sbjct: 127  PFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLL 186

Query: 1303 LHQGAYFRDLWNILDFIVVSGALVAFAF-------------TGNSKGKDINTIKSLRVLR 1349
            LH  AY R+ WN+LDF++V   L +                +G S G D   +K+LR  R
Sbjct: 187  LHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFD---VKALRAFR 243

Query: 1350 VLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGK-----FF 1404
            VLRPL+ +  +P L+ V + ++ ++  + +I ++ +  + I+A++ ++LF GK     FF
Sbjct: 244  VLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFF 303

Query: 1405 HCTD-ESKEFEKDC----RGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTG 1459
              +D  ++E    C     G+       E ++          ++DN  +A+LT+F   T 
Sbjct: 304  ADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITM 363

Query: 1460 EGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFV-NIFVALIIITFQEQ- 1517
            EGW  VL    DA             E+   Y V  V+F  FFV N+ + ++   F ++ 
Sbjct: 364  EGWTDVLYWMNDA----------MGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKER 413

Query: 1518 ------GD--KMMEEYSLEKNERACIDFAISAK--------------------------- 1542
                  GD  K+ E+  LE++ +  +D+   A+                           
Sbjct: 414  EKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETES 473

Query: 1543 -----------------PLTRHMPQNKQSFQYRMWQ---------FVVSPPFEYTIMAMI 1576
                              L + + ++K S ++R W           V S  F + ++ ++
Sbjct: 474  VNTENVSGEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLV 533

Query: 1577 ALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFV 1636
             LNT+ +  + Y           + N V  +LF+ E ++K+ + G+  YF   +N FD  
Sbjct: 534  FLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCF 593

Query: 1637 TVLGSITDILVTEFG-NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1695
             V G IT+ ++ E    + + +S  R  R  R+ K+ R   ++  L+ + + S K++  +
Sbjct: 594  VVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASL 653

Query: 1696 CLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATG 1755
             LL+ +   I++++GMQ+FG           + DE Q T+ + F  F QAL+ +F+  TG
Sbjct: 654  LLLLFLFIIIFSLLGMQLFGG--------KFNFDETQ-TKRSTFDNFPQALLTVFQILTG 704

Query: 1756 EAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
            E W+ +M   +       +SG++           YF+  +F+C ++++LN+F+A+ +DN
Sbjct: 705  EDWNAVMYDGIMAYGGPSSSGMI--------VCIYFI-ILFICGNYILLNVFLAIAVDN 754



 Score =  188 bits (477), Expect = 6e-47
 Identities = 169/706 (23%), Positives = 297/706 (42%), Gaps = 153/706 (21%)

Query: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
            + F+ S+ N +R    K+     F  +IL  I+ +   LA E   P    +  +  L   
Sbjct: 865  AFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAED--PIRSHSFRNTILGYF 922

Query: 137  EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
            +  F  IF  E  +K+   G   HKG++ RN +N++D +VV    L + G +      ++
Sbjct: 923  DYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVS-LVSFGIQSSAISVVK 981

Query: 193  TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      +FA IG++ + GKF
Sbjct: 982  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1041

Query: 253  HTTCFEEGTDDIQ-----------GESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQF 301
            +  C +E   + +           G+  +P   E               W+   N    F
Sbjct: 1042 YR-CTDEAKSNPEECRGLFILYKDGDVDSPVVRER-------------IWQ---NSDFNF 1084

Query: 302  DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLY---------FIPLIIIGSFFML 352
            DN+L A++ +F   T EGW  LLY + D++G     +Y         FI  III +FFM+
Sbjct: 1085 DNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMM 1144

Query: 353  NLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGE 412
            N+ +G                  F+ +  Q+Q E+E                   E D  
Sbjct: 1145 NIFVG------------------FVIVTFQEQGEKEYKNC---------------ELDKN 1171

Query: 413  QRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKK 472
            QR   + AL+   +++                                       +  K 
Sbjct: 1172 QRQCVEYALKARPLRR---------------------------------------YIPKN 1192

Query: 473  ERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMS 532
              + +F+   +V +  F + +  L+ LNTLC+A+ HY Q +  +D +     +F G+F  
Sbjct: 1193 PYQYKFWY--VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTV 1250

Query: 533  EMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTS---------------- 576
            EM +K+     + YF  ++N FD  ++IGSI +V  +   P  S                
Sbjct: 1251 EMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEES 1310

Query: 577  --FGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQ 634
                I+  R  R++R+ K+      +R L+ + + S +++  +  L+ +   ++A++GMQ
Sbjct: 1311 NRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQ 1370

Query: 635  LFGGQFNFDEG--TPPTNFDTFPAAIMTVFQILTGEDWNEVMY------------DGIKS 680
            +FG     D        NF TFP A++ +F+  TGE W E+M             D    
Sbjct: 1371 MFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPG 1430

Query: 681  QGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
            +    G     +YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1431 EEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1473



 Score =  139 bits (349), Expect = 4e-32
 Identities = 177/787 (22%), Positives = 321/787 (40%), Gaps = 169/787 (21%)

Query: 24   VVGSGGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSE 83
            V G G  RG  GS        Q + K  +++R R    +N    R+ C            
Sbjct: 479  VSGEGENRGCCGSL------CQAISKSKLSRRWRRWNRFN----RRRC------------ 516

Query: 84   DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 143
                R   K +T    F ++++  +  N + ++ E +   D  T +    D      + +
Sbjct: 517  ----RAAVKSVT----FYWLVIVLVFLNTLTISSEHYNQPDWLTQIQ---DIANKVLLAL 565

Query: 144  FCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT------LRAV 197
            F  E  +K+ +LG      +Y  + +N  D  VV  GI  T+  E ++ +       R V
Sbjct: 566  FTCEMLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCV 621

Query: 198  RVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF 257
            R+LR  K+     SL  ++ S++ +M  +  + LLLF  I+IF+++G++ + GKF+   F
Sbjct: 622  RLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFN---F 678

Query: 258  EEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITM 317
            +E              T+    T                    FDN   A+LTVFQ +T 
Sbjct: 679  DE--------------TQTKRST--------------------FDNFPQALLTVFQILTG 704

Query: 318  EGWTDLLYNSNDASGNTWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEFAK------- 365
            E W  ++Y+   A G   +      +YFI L I G++ +LN+ L +     A        
Sbjct: 705  EDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTA 764

Query: 366  ERERVENRRAFLKLRRQQQIERELNGYME--WISKAEEVILAED-ETDGEQRHPFDGALR 422
            ++E  E +    K+ R++ +E + N   E   I+ ++  +  +D   + E + P+     
Sbjct: 765  QKEEAEEKER-KKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPC-- 821

Query: 423  RTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKL--------ENSTFFH-KKE 473
                     D+   EE E++  D   V +      I    +        E S FF   K 
Sbjct: 822  ---------DVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKT 872

Query: 474  RRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH-YNQPEWLSDFLYYAEFIFLGLFMS 532
              +R    +++    F   +L  + L++  +A         + +  L Y ++ F  +F  
Sbjct: 873  NPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTV 932

Query: 533  EMFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLL 588
            E+ +KM   G       +  + FN  D  V+  S+  V + +     S  + +LR LR+L
Sbjct: 933  EILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSL--VSFGIQSSAISV-VKILRVLRVL 989

Query: 589  RIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF-------- 640
            R  +       L+++V  +  ++++I +++ +  L   +FA +G+QLF G+F        
Sbjct: 990  RPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAK 1049

Query: 641  --------------NFDEGTPPT----------NFDTFPAAIMTVFQILTGEDWNEVMYD 676
                          + D  +P            NFD   +A+M +F + T E W  ++Y 
Sbjct: 1050 SNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYK 1109

Query: 677  GIKSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEE 731
             I S G   G +       SI+FI+  +   + ++N+F+   +        +T  EQ E+
Sbjct: 1110 AIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVI--------VTFQEQGEK 1161

Query: 732  EAANQKL 738
            E  N +L
Sbjct: 1162 EYKNCEL 1168



 Score = 80.9 bits (198), Expect = 1e-14
 Identities = 74/296 (25%), Positives = 131/296 (44%), Gaps = 61/296 (20%)

Query: 1567 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1623
            PF+  I+  I  N + L +        S +  + L      F  +F++E  LK++A+G+L
Sbjct: 127  PFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLL 186

Query: 1624 ----NYFRDAWNIFDFVTVLGSITDILV------TEFGNNF------INLSFLRLFRAAR 1667
                 Y R+ WN+ DFV V+  +  +++      TE GN+        ++  LR FR  R
Sbjct: 187  LHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLR 246

Query: 1668 LIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-GNIGIDVEDEDS 1726
             ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F G +       DS
Sbjct: 247  PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADS 306

Query: 1727 D----EDEF---------QITEHN---------------NFRTFFQALMLLFRSATGEAW 1758
            D    ED           Q T +                NF  F  A++ +F+  T E W
Sbjct: 307  DIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGW 366

Query: 1759 HNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
             +++               +    G E  + YFVS +   SF +LNL + V+   F
Sbjct: 367  TDVLYW-------------MNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 409


>gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D
            subunit isoform a [Homo sapiens]
          Length = 2181

 Score =  773 bits (1997), Expect = 0.0
 Identities = 399/825 (48%), Positives = 552/825 (66%), Gaps = 56/825 (6%)

Query: 1192 PDPLPKKEEEKKEEEEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLC 1237
            P  +P  EEE++EEE++     GP+P              +P  S+ FILS TNP+R  C
Sbjct: 840  PCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGC 899

Query: 1238 HYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMI 1297
            H ++N   F   IL+ I +SS ALAAEDP++ ++ RN +L YFDY FT +FT E+++KM 
Sbjct: 900  HKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMT 959

Query: 1298 DLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTI 1357
              G  LH+GA+ R+ +N+LD +VV  +LV+F    ++    I+ +K LRVLRVLRPL+ I
Sbjct: 960  TFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSA----ISVVKILRVLRVLRPLRAI 1015

Query: 1358 KRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC 1417
             R   LK V  CV  +++ + NI+IV  L  F+FA + VQLFKGKF+ CTDE+K   ++C
Sbjct: 1016 NRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEEC 1075

Query: 1418 RGKYLLYEKNEVKA---RDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
            RG ++LY+  +V +   R+R W+  +F++DNVL A++ LFTVST EGWP +L  ++D+  
Sbjct: 1076 RGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNG 1135

Query: 1475 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERAC 1534
            EN GP   +R+E+SIF+++Y ++  FF +NIFV  +I+TFQEQG+K  +   L+KN+R C
Sbjct: 1136 ENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQC 1195

Query: 1535 IDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAY 1594
            +++A+ A+PL R++P+N   +QY+ W  V S PFEY +  +I LNT+ L M+ Y  S  +
Sbjct: 1196 VEYALKARPLRRYIPKNP--YQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMF 1253

Query: 1595 ENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEF---- 1650
             +A+ + N+VFT +F++E VLKV+AF    YF DAWN FD + V+GSI D+ ++E     
Sbjct: 1254 NDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTE 1313

Query: 1651 -----------GN----NFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1695
                       GN    N I+++F RLFR  RL+KLL +G  IR LLWTF++SF+ALPYV
Sbjct: 1314 SENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYV 1373

Query: 1696 CLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATG 1755
             LLIAMLFFIYA+IGMQ+FG + +         D  QI  +NNF+TF QA++LLFR ATG
Sbjct: 1374 ALLIAMLFFIYAVIGMQMFGKVAM--------RDNNQINRNNNFQTFPQAVLLLFRCATG 1425

Query: 1756 EAWHNIMLSCLSGKPCDKNSGILTRE---CGNEFAYFYFVSFIFLCSFLMLNLFVAVIMD 1812
            EAW  IML+CL GK CD  S     E   CG+ FA  YF+SF  LC+FL++NLFVAVIMD
Sbjct: 1426 EAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMD 1485

Query: 1813 NFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHR 1872
            NF+YLTRD SILGPHHLDE+ R+W+EYDP A GRI + D+ +LLR I PPLG GK CPHR
Sbjct: 1486 NFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHR 1545

Query: 1873 VACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWP 1932
            VACKRL+ M++P+  D TV FN+TL AL+RTAL IK      + +Q + ELR  +  IW 
Sbjct: 1546 VACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE---GNLEQANEELRAVIKKIWK 1602

Query: 1933 NLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAM 1977
              S K LD +V P    ++TVGK YA  +I +Y+R+ K +K Q +
Sbjct: 1603 KTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGL 1647



 Score =  655 bits (1689), Expect = 0.0
 Identities = 357/740 (48%), Positives = 474/740 (64%), Gaps = 51/740 (6%)

Query: 76  RSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDD 135
           R+LF  S +N +R+    I EW PF+  IL  I ANC+ LA+    P+DD    +  L+ 
Sbjct: 104 RALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEK 163

Query: 136 TEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------- 188
            E  F+ IF  E  +KIIA G   H  +Y+RNGWN++DFV+V+ G+ + +  +       
Sbjct: 164 VEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEG 223

Query: 189 ----------FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAIL 238
                     FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAM+PLL I LL+ F I+
Sbjct: 224 GNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 283

Query: 239 IFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCP-NGTKCQPYWEGPNNG 297
           I+AIIGLE ++GK H TCF   +D +  E PAPC      R C  NGT+C+  W GPN G
Sbjct: 284 IYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGG 343

Query: 298 ITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLG 357
           IT FDN  FA+LTVFQCITMEGWTD+LY  NDA G  W W+YF+ LII+GSFF+LNLVLG
Sbjct: 344 ITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLG 403

Query: 358 VLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPF 417
           VLSGEF+KERE+ + R  F KLR +QQ+E +L GY++WI++AE++    +E  GE+    
Sbjct: 404 VLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEE---- 459

Query: 418 DGALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFA----RASIKSAK---------LE 464
               R T++  S+T+ +N E    +  +    GS +     R + K+           + 
Sbjct: 460 --GKRNTSMPTSETESVNTENVSGEGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAIS 517

Query: 465 NSTFFHKKERRMRFYIRRM---VKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYY 521
            S    +  R  RF  RR    VK+  FYW V+ LV LNTL ++  HYNQP+WL+     
Sbjct: 518 KSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDI 577

Query: 522 AEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISV 581
           A  + L LF  EM +KMY LG + YF S FN FDC V+ G I E I   ++  +  GISV
Sbjct: 578 ANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISV 637

Query: 582 LRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFN 641
            R +RLLRIFKVT++W SL NLV SLLNSMKSI SLL LLFLFI++F+LLGMQLFGG+FN
Sbjct: 638 FRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFN 697

Query: 642 FDE-GTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGG-VQGGMVFSIYFIVLTL 699
           FDE  T  + FD FP A++TVFQILTGEDWN VMYDGI + GG    GM+  IYFI+L +
Sbjct: 698 FDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFI 757

Query: 700 FGNYTLLNVFLAIAVDNLANAQEL-TKDEQEEEEAANQKLALQKAKE-----VAEVSPLS 753
            GNY LLNVFLAIAVDNLA+A+ L T  ++E EE   +K+A +++ E       EV+ ++
Sbjct: 758 CGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIA 817

Query: 754 AANMSIAV---KEQQKNQKP 770
            ++  + +   +E+ +++ P
Sbjct: 818 NSDNKVTIDDYREEDEDKDP 837



 Score =  188 bits (477), Expect = 6e-47
 Identities = 169/706 (23%), Positives = 297/706 (42%), Gaps = 153/706 (21%)

Query: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
            + F+ S+ N +R    K+     F  +IL  I+ +   LA E   P    +  +  L   
Sbjct: 885  AFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAED--PIRSHSFRNTILGYF 942

Query: 137  EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
            +  F  IF  E  +K+   G   HKG++ RN +N++D +VV    L + G +      ++
Sbjct: 943  DYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVS-LVSFGIQSSAISVVK 1001

Query: 193  TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      +FA IG++ + GKF
Sbjct: 1002 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1061

Query: 253  HTTCFEEGTDDIQ-----------GESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQF 301
            +  C +E   + +           G+  +P   E               W+   N    F
Sbjct: 1062 YR-CTDEAKSNPEECRGLFILYKDGDVDSPVVRER-------------IWQ---NSDFNF 1104

Query: 302  DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLY---------FIPLIIIGSFFML 352
            DN+L A++ +F   T EGW  LLY + D++G     +Y         FI  III +FFM+
Sbjct: 1105 DNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMM 1164

Query: 353  NLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGE 412
            N+ +G                  F+ +  Q+Q E+E                   E D  
Sbjct: 1165 NIFVG------------------FVIVTFQEQGEKEYKNC---------------ELDKN 1191

Query: 413  QRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKK 472
            QR   + AL+   +++                                       +  K 
Sbjct: 1192 QRQCVEYALKARPLRR---------------------------------------YIPKN 1212

Query: 473  ERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMS 532
              + +F+   +V +  F + +  L+ LNTLC+A+ HY Q +  +D +     +F G+F  
Sbjct: 1213 PYQYKFWY--VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTV 1270

Query: 533  EMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTS---------------- 576
            EM +K+     + YF  ++N FD  ++IGSI +V  +   P  S                
Sbjct: 1271 EMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEES 1330

Query: 577  --FGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQ 634
                I+  R  R++R+ K+      +R L+ + + S +++  +  L+ +   ++A++GMQ
Sbjct: 1331 NRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQ 1390

Query: 635  LFGGQFNFDEG--TPPTNFDTFPAAIMTVFQILTGEDWNEVMY------------DGIKS 680
            +FG     D        NF TFP A++ +F+  TGE W E+M             D    
Sbjct: 1391 MFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPG 1450

Query: 681  QGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
            +    G     +YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1451 EEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1493



 Score =  137 bits (346), Expect = 9e-32
 Identities = 105/403 (26%), Positives = 194/403 (48%), Gaps = 49/403 (12%)

Query: 1185 QVNKNANPDPLPKKEEEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLR 1244
            Q    + P P+    + K+++    + +       P  ++F LS  NP+RR C  I+  +
Sbjct: 67   QTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWK 126

Query: 1245 YFEMCILMVIAMSSIALAAEDPVQPNAPR--NNVLRYFDYVFTGVFTFEMVIKMIDLGLV 1302
             F++ IL+ I  + +ALA   P   +     N+ L   +Y F  +FT E  +K+I  GL+
Sbjct: 127  PFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLL 186

Query: 1303 LHQGAYFRDLWNILDFIVVSGALVAFAF-------------TGNSKGKDINTIKSLRVLR 1349
            LH  AY R+ WN+LDF++V   L +                +G S G D   +K+LR  R
Sbjct: 187  LHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFD---VKALRAFR 243

Query: 1350 VLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGK-----FF 1404
            VLRPL+ +  +P L+ V + ++ ++  + +I ++ +  + I+A++ ++LF GK     FF
Sbjct: 244  VLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFF 303

Query: 1405 HCTD-ESKEFEKDC----RGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTG 1459
              +D  ++E    C     G+       E ++          ++DN  +A+LT+F   T 
Sbjct: 304  ADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITM 363

Query: 1460 EGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-- 1517
            EGW  VL    DA         G+     +++V   ++  FF +N+ + ++   F ++  
Sbjct: 364  EGWTDVLYWVNDAI--------GWEWPW-VYFVSLIILGSFFVLNLVLGVLSGEFSKERE 414

Query: 1518 -----GD--KMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQ 1553
                 GD  K+ E+  LE++ +  +D+   A+ +    P+N++
Sbjct: 415  KAKARGDFQKLREKQQLEEDLKGYLDWITQAEDID---PENEE 454



 Score =  137 bits (345), Expect = 1e-31
 Identities = 181/801 (22%), Positives = 327/801 (40%), Gaps = 177/801 (22%)

Query: 24   VVGSGGGRGAGGS------RQG----GQPGAQR----MYKQSMAQRARTMALYNPIPVRQ 69
            V G G  RG  GS      R+G    G  G +R    + K  +++R R    +N    R+
Sbjct: 479  VSGEGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSRRWRRWNRFN----RR 534

Query: 70   NCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPM 129
             C                R   K +T    F ++++  +  N + ++ E +   D  T +
Sbjct: 535  RC----------------RAAVKSVT----FYWLVIVLVFLNTLTISSEHYNQPDWLTQI 574

Query: 130  SERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEF 189
                D      + +F  E  +K+ +LG      +Y  + +N  D  VV  GI  T+  E 
Sbjct: 575  Q---DIANKVLLALFTCEMLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVEL 627

Query: 190  DLRT------LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAII 243
            ++ +       R VR+LR  K+     SL  ++ S++ +M  +  + LLLF  I+IF+++
Sbjct: 628  EIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLL 687

Query: 244  GLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDN 303
            G++ + GKF+   F+E              T+    T                    FDN
Sbjct: 688  GMQLFGGKFN---FDE--------------TQTKRST--------------------FDN 710

Query: 304  ILFAVLTVFQCITMEGWTDLLYNSNDASGNTWN-----WLYFIPLIIIGSFFMLNLVLGV 358
               A+LTVFQ +T E W  ++Y+   A G   +      +YFI L I G++ +LN+ L +
Sbjct: 711  FPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAI 770

Query: 359  LSGEFAK-------ERERVENRRAFLKLRRQQQIERELNGYME--WISKAEEVILAED-E 408
                 A        ++E  E +    K+ R++ +E + N   E   I+ ++  +  +D  
Sbjct: 771  AVDNLADAESLNTAQKEEAEEKER-KKIARKESLENKKNNKPEVNQIANSDNKVTIDDYR 829

Query: 409  TDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKL----- 463
             + E + P+              D+   EE E++  D   V +      I    +     
Sbjct: 830  EEDEDKDPYPPC-----------DVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIA 878

Query: 464  ---ENSTFFH-KKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH-YNQPEWLSDF 518
               E S FF   K   +R    +++    F   +L  + L++  +A         + +  
Sbjct: 879  PIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTI 938

Query: 519  LYYAEFIFLGLFMSEMFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPG 574
            L Y ++ F  +F  E+ +KM   G       +  + FN  D  V+  S+  V + +    
Sbjct: 939  LGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSL--VSFGIQSSA 996

Query: 575  TSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQ 634
             S  + +LR LR+LR  +       L+++V  +  ++++I +++ +  L   +FA +G+Q
Sbjct: 997  ISV-VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQ 1055

Query: 635  LFGGQF----------------------NFDEGTPPT----------NFDTFPAAIMTVF 662
            LF G+F                      + D  +P            NFD   +A+M +F
Sbjct: 1056 LFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALF 1115

Query: 663  QILTGEDWNEVMYDGIKSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAVDNL 717
             + T E W  ++Y  I S G   G +       SI+FI+  +   + ++N+F+   +   
Sbjct: 1116 TVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVI--- 1172

Query: 718  ANAQELTKDEQEEEEAANQKL 738
                 +T  EQ E+E  N +L
Sbjct: 1173 -----VTFQEQGEKEYKNCEL 1188



 Score =  106 bits (264), Expect = 3e-22
 Identities = 74/278 (26%), Positives = 141/278 (50%), Gaps = 20/278 (7%)

Query: 1538 AISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENA 1597
            AIS   L+R   +  +  + R    V S  F + ++ ++ LNT+ +  + Y         
Sbjct: 515  AISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQI 574

Query: 1598 LRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFG-NNFIN 1656
              + N V  +LF+ E ++K+ + G+  YF   +N FD   V G IT+ ++ E    + + 
Sbjct: 575  QDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLG 634

Query: 1657 LSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGN 1716
            +S  R  R  R+ K+ R   ++  L+ + + S K++  + LL+ +   I++++GMQ+FG 
Sbjct: 635  ISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGG 694

Query: 1717 IGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSG 1776
                      + DE Q T+ + F  F QAL+ +F+  TGE W+ +M   +       +SG
Sbjct: 695  --------KFNFDETQ-TKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSG 745

Query: 1777 ILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
            ++           YF+  +F+C ++++LN+F+A+ +DN
Sbjct: 746  MI--------VCIYFI-ILFICGNYILLNVFLAIAVDN 774



 Score = 91.3 bits (225), Expect = 1e-17
 Identities = 70/278 (25%), Positives = 128/278 (46%), Gaps = 38/278 (13%)

Query: 1234 RRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMV 1293
            RR C   +    F   +++++ ++++ +++E   QP+     +    + V   +FT EM+
Sbjct: 533  RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDW-LTQIQDIANKVLLALFTCEML 591

Query: 1294 IKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRP 1353
            +KM  LGL     AYF  L+N  D  VV G +             +  I   R +R+LR 
Sbjct: 592  VKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVELEIMSPLG-ISVFRCVRLLRI 646

Query: 1354 LKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEF 1413
             K  +    L  +   ++NS+K++ ++L++  LF+ IF+++ +QLF GKF     ++K  
Sbjct: 647  FKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRS 706

Query: 1414 EKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDAT 1473
                                         +DN   ALLT+F + TGE W  V+    D  
Sbjct: 707  T----------------------------FDNFPQALLTVFQILTGEDWNAVM---YDGI 735

Query: 1474 FENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALII 1511
                GPS    M + I++++ F+   +  +N+F+A+ +
Sbjct: 736  MAYGGPSSS-GMIVCIYFIILFICGNYILLNVFLAIAV 772



 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 78/296 (26%), Positives = 134/296 (45%), Gaps = 61/296 (20%)

Query: 1567 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1623
            PF+  I+  I  N + L +        S +  + L      F  +F++E  LK++A+G+L
Sbjct: 127  PFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLL 186

Query: 1624 ----NYFRDAWNIFDFVTVLGSITDILV------TEFGNNF------INLSFLRLFRAAR 1667
                 Y R+ WN+ DFV V+  +  +++      TE GN+        ++  LR FR  R
Sbjct: 187  LHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLR 246

Query: 1668 LIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-GNIGIDVEDEDS 1726
             ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F G +       DS
Sbjct: 247  PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADS 306

Query: 1727 D----EDEF---------QITEH---------------NNFRTFFQALMLLFRSATGEAW 1758
            D    ED           Q T +                NF  F  A++ +F+  T E W
Sbjct: 307  DIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGW 366

Query: 1759 HNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
             +++           N  I     G E+ + YFVS I L SF +LNL + V+   F
Sbjct: 367  TDVLYWV--------NDAI-----GWEWPWVYFVSLIILGSFFVLNLVLGVLSGEF 409


>gi|193788530 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 9 [Homo sapiens]
          Length = 2157

 Score =  773 bits (1995), Expect = 0.0
 Identities = 410/885 (46%), Positives = 568/885 (64%), Gaps = 69/885 (7%)

Query: 1146 IVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEE 1205
            +V  P+  ++   K   K      + PPA    +N   +Q N+N +  P P  E   +E+
Sbjct: 790  LVEKPAVGESKEEKIELKSITADGESPPATK--INMDDLQPNENEDKSPYPNPETTGEED 847

Query: 1206 EEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLCHYILNLRYFEMCIL 1251
            EE+     GP+P              MP  S+ FI S+ N  R  CH I+N   F   IL
Sbjct: 848  EEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLIL 907

Query: 1252 MVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRD 1311
              I +SSI+LAAEDPVQ  + RN++L   DYVFT +FT E+++KM   G  LH+G++ R+
Sbjct: 908  FFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRN 967

Query: 1312 LWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVV 1371
             +NILD +VVS +L++F    ++    IN +K LRVLRVLRPL+ I R   LK V  CV 
Sbjct: 968  YFNILDLLVVSVSLISFGIQSSA----INVVKILRVLRVLRPLRAINRAKGLKHVVQCVF 1023

Query: 1372 NSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK- 1430
             +++ + NI+IV  L  F+FA + VQLFKGK + C+D SK+ E +C+G Y+ Y+  EV  
Sbjct: 1024 VAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDH 1083

Query: 1431 --ARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMS 1488
               + R W+  +F +DNVL A++ LFTVST EGWP++L  S+D+  E++GP   YR+E+S
Sbjct: 1084 PIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEIS 1143

Query: 1489 IFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHM 1548
            IF+++Y ++  FF +NIFV  +I+TFQEQG++  +   L+KN+R C+++A+ A+PL R++
Sbjct: 1144 IFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYI 1203

Query: 1549 PQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSL 1608
            P+N+   QY++W  V S  FEY +  +I LNTI L M+ YG S  ++ A+ + N++FT L
Sbjct: 1204 PKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGL 1261

Query: 1609 FSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFG---------------NN 1653
            F++E +LK++AF   +YF DAWN FD + V+GSI DI +TE                 N+
Sbjct: 1262 FTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENS 1321

Query: 1654 FINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQV 1713
             I+++F RLFR  RL+KLL +G  IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQV
Sbjct: 1322 RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV 1381

Query: 1714 FGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPC-- 1771
            FG I ++        D  +I  +NNF+TF QA++LLFR ATGEAW +IML+C+ GK C  
Sbjct: 1382 FGKIALN--------DTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAP 1433

Query: 1772 ---DKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHH 1828
                 NS      CG+ FA FYF+SF  LC+FL++NLFVAVIMDNF+YLTRD SILGPHH
Sbjct: 1434 ESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHH 1493

Query: 1829 LDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADD 1888
            LDE+ R+WAEYDP A GRI + D+ +LLR I PPLG GK CPHRVACKRL+ M++P+  D
Sbjct: 1494 LDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSD 1553

Query: 1889 NTVHFNSTLMALIRTALDIKIAKG--------GADK--------QQMDAELRKEMMAIWP 1932
             TV FN+TL AL+RTAL IK  +G        GA+         +Q + ELR  +  IW 
Sbjct: 1554 GTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWK 1613

Query: 1933 NLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAM 1977
              S K LD +V P    ++TVGK YA  +I EY+R+ K +K Q +
Sbjct: 1614 RTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGL 1658



 Score =  671 bits (1730), Expect = 0.0
 Identities = 383/827 (46%), Positives = 507/827 (61%), Gaps = 64/827 (7%)

Query: 2   ARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQG-----------GQPGAQRMYKQ 50
           + +G   PA +    + AAAG+        GA  S Q            G  G   +   
Sbjct: 18  SNYGSPRPA-HANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTV 76

Query: 51  SMAQRARTMALYNPIPVRQNCLTVNR---SLFLFSEDNVVRKYAKKITEWPPFEYMILAT 107
           S  QR R    Y   P +Q   T  R   +L   +  N +R+    I EW PFE +IL T
Sbjct: 77  SSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLT 133

Query: 108 IIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRN 167
           I ANC+ LA+    P+DD    +  L+  E  F+ IF  EA +K+IA G  FH  +YLRN
Sbjct: 134 IFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRN 193

Query: 168 GWNVMDFVVVLTGILATV----------------GTEFDLRTLRAVRVLRPLKLVSGIPS 211
           GWN++DF++V+ G+ + +                G  FD++ LRA RVLRPL+LVSG+PS
Sbjct: 194 GWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPS 253

Query: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF-EEGTDDIQGES-P 269
           LQVVL SI+KAM+PLL I LL+ F I+I+AIIGLE +MGK H TC+ +EG  D+  E  P
Sbjct: 254 LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 270 APCGTEEP-ARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSN 328
           +PC  E    R C NGT C+P W+GP +GIT FDN  FA+LTVFQCITMEGWTD+LY  N
Sbjct: 314 SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 329 DASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 388
           DA G  W W+YF+ LIIIGSFF+LNLVLGVLSGEF+KERE+ + R  F KLR +QQ+E +
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433

Query: 389 LNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIAS 448
           L GY++WI++AE++    ++   ++  P     R  ++  S+T+ +N E       +  +
Sbjct: 434 LKGYLDWITQAEDIDPENEDEGMDEEKP-----RNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 449 VGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH 508
            G   AR + + +K + S ++ +  R  R   R  VK+  FYW V+ LV LNTL +A  H
Sbjct: 489 CG---ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEH 545

Query: 509 YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIW 568
           YNQP WL++    A    L LF +EM +KMY LG + YF S FN FDC V+ G I E I 
Sbjct: 546 YNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETIL 605

Query: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
              K  +  GISVLR +RLLRIFK+T+YW SL NLV SLLNS++SI SLL LLFLFI++F
Sbjct: 606 VETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIF 665

Query: 629 ALLGMQLFGGQFNFDE-GTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQ-G 686
           +LLGMQLFGG+FNFDE  T  + FD FP +++TVFQILTGEDWN VMYDGI + GG    
Sbjct: 666 SLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 687 GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEV 746
           GM+  IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EEEE   +K         
Sbjct: 726 GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERK--------- 776

Query: 747 AEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREA 793
                   A  +   K+Q+  +KPA  V E +  ++  +++ A  E+
Sbjct: 777 ------KLARTASPEKKQELVEKPA--VGESKEEKIELKSITADGES 815



 Score =  202 bits (513), Expect = 4e-51
 Identities = 176/705 (24%), Positives = 317/705 (44%), Gaps = 120/705 (17%)

Query: 1200 EEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSI 1259
            + K+++    + +       P  ++  L+  NP+RR C  I+  + FE+ IL+ I  + +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1260 ALAAEDPV---QPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNIL 1316
            ALA   P      NA  +N+ R  +Y+F  +FT E  +K+I  GL+ H  AY R+ WN+L
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV-EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198

Query: 1317 DFIVVSGALVAFAFTGNSKGKDINT---------IKSLRVLRVLRPLKTIKRLPKLKAVF 1367
            DFI+V   L +      +K    N          +K+LR  RVLRPL+ +  +P L+ V 
Sbjct: 199  DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258

Query: 1368 DCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC---------- 1417
            + ++ ++  + +I ++ +  + I+A++ ++LF GK  H T  ++E   D           
Sbjct: 259  NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK-MHKTCYNQEGIADVPAEDDPSPCA 317

Query: 1418 --RGKYLLYEKNEVKARDREWKKYEF-HYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
               G     +   V     +  K+   ++DN  +A+LT+F   T EGW  VL    DA  
Sbjct: 318  LETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAV- 376

Query: 1475 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KMMEEY 1525
                     R    I++V   ++  FF +N+ + ++   F ++       GD  K+ E+ 
Sbjct: 377  --------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428

Query: 1526 SLEKNERACIDFAISA---------------KPLTRHMP--------------------- 1549
             LE++ +  +D+   A               KP    MP                     
Sbjct: 429  QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 1550 ----------QNKQSFQYRMWQ---------FVVSPPFEYTIMAMIALNTIVLMMKFYGA 1590
                      ++K S  +R W           V S  F + ++ ++ LNT+ +  + Y  
Sbjct: 489  CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548

Query: 1591 SVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITD-ILVTE 1649
                       N    +LF+ E +LK+ + G+  YF   +N FD   V G I + ILV  
Sbjct: 549  PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 1650 FGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAII 1709
               + + +S LR  R  R+ K+ R   ++  L+ + + S +++  + LL+ +   I++++
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 1710 GMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGK 1769
            GMQ+FG           + DE Q T  + F  F Q+L+ +F+  TGE W+++M   +   
Sbjct: 669  GMQLFGG--------KFNFDEMQ-TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAY 719

Query: 1770 PCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
                  G+L           YF+  +F+C ++++LN+F+A+ +DN
Sbjct: 720  GGPSFPGML--------VCIYFI-ILFICGNYILLNVFLAIAVDN 755



 Score =  143 bits (360), Expect = 2e-33
 Identities = 179/785 (22%), Positives = 325/785 (41%), Gaps = 161/785 (20%)

Query: 33   AGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAK 92
            AGG  +G   GA+  ++ S ++ +R    +N    R+ C    +S       NV      
Sbjct: 480  AGGDIEGENCGARLAHRISKSKFSRYWRRWNRF-CRRKCRAAVKS-------NV------ 525

Query: 93   KITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKI 152
                   F ++++  +  N + +A E +   +    ++E  D      + +F  E  +K+
Sbjct: 526  -------FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKM 575

Query: 153  IALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------FDLRTLRAVRVLRPLKLV 206
             +LG      +Y  + +N  D  VV  GIL T+  E        +  LR VR+LR  K+ 
Sbjct: 576  YSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKIT 631

Query: 207  SGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQG 266
                SL  ++ S++ ++  +  + LLLF  I+IF+++G++ + GKF+        D++Q 
Sbjct: 632  RYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF-------DEMQT 684

Query: 267  ESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYN 326
                                            + FDN   ++LTVFQ +T E W  ++Y+
Sbjct: 685  RR------------------------------STFDNFPQSLLTVFQILTGEDWNSVMYD 714

Query: 327  SNDASGNT-----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERE 368
               A G          +YFI L I G++ +LN+ L +     A             +E+E
Sbjct: 715  GIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKE 774

Query: 369  RVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIK- 427
            R +  R     ++Q+ +E+   G     SK E++ L     DGE   P    +    ++ 
Sbjct: 775  RKKLARTASPEKKQELVEKPAVGE----SKEEKIELKSITADGES--PPATKINMDDLQP 828

Query: 428  ---KSKTDLLNPEEA--EDQLADIASVGS---PFARASIKSAKL---ENSTFF-HKKERR 475
               + K+   NPE    ED+      VG    P +   +K   +   E S FF      R
Sbjct: 829  NENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNR 888

Query: 476  MRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ-PEWLSDFLYYAEFIFLGLFMSEM 534
             R    R+V    F   +L  + L+++ +A     Q   + +  L  A+++F  +F  E+
Sbjct: 889  FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEI 948

Query: 535  FIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRI 590
             +KM   G       +  + FN  D  V+  S+       I+      + +LR LR+LR 
Sbjct: 949  ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRP 1005

Query: 591  FKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQ-FNFDEGTPPT 649
             +       L+++V  +  ++++I +++ +  L   +FA +G+QLF G+ +   + +  T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 650  -------------------------------NFDTFPAAIMTVFQILTGEDWNEVMYDGI 678
                                           +FD   AA+M +F + T E W E++Y  I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 679  KSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEA 733
             S    +G +       SI+FI+  +   + ++N+F+   +        +T  EQ E+E 
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEY 1177

Query: 734  ANQKL 738
             N +L
Sbjct: 1178 KNCEL 1182



 Score =  116 bits (291), Expect = 2e-25
 Identities = 96/331 (29%), Positives = 163/331 (49%), Gaps = 33/331 (9%)

Query: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
            + F+FS +N  R    +I     F  +IL  I+ + I LA E   P    +  +  L + 
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILGNA 936

Query: 137  EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV   ++ + G +      ++
Sbjct: 937  DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLI-SFGIQSSAINVVK 995

Query: 193  TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      +FA IG++ + GK 
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 253  HTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----WEGPNNGITQFDNILFA 307
            +T        D   ++ A C  +    T  +G    P      WE   N    FDN+L A
Sbjct: 1056 YT------CSDSSKQTEAEC--KGNYITYKDGEVDHPIIQPRSWE---NSKFDFDNVLAA 1104

Query: 308  VLTVFQCITMEGWTDLLYNSNDA----SGNTWNW-----LYFIPLIIIGSFFMLNLVLGV 358
            ++ +F   T EGW +LLY S D+     G  +N+     ++FI  III +FFM+N+ +G 
Sbjct: 1105 MMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGF 1164

Query: 359  LSGEFAKERERVENRRAFLKLRRQQQIEREL 389
            +   F ++ E+ E +   L   ++Q +E  L
Sbjct: 1165 VIVTFQEQGEQ-EYKNCELDKNQRQCVEYAL 1194



 Score =  113 bits (282), Expect = 2e-24
 Identities = 74/294 (25%), Positives = 138/294 (46%), Gaps = 42/294 (14%)

Query: 472  KERRMRFYIRR---------MVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 522
            K R +R YI +         +V +  F + +  L+ LNT+C+A+ HY Q       +   
Sbjct: 1195 KARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNIL 1254

Query: 523  EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKP--------- 573
              +F GLF  EM +K+     + YF  ++N FD  +++GSI ++    + P         
Sbjct: 1255 NMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPS 1314

Query: 574  -----GTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
                  +   I+  R  R++R+ K+      +R L+ + + S +++  +  L+ +   ++
Sbjct: 1315 MNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIY 1374

Query: 629  ALLGMQLFG--GQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMY----------- 675
            A++GMQ+FG     +  E     NF TFP A++ +F+  TGE W ++M            
Sbjct: 1375 AVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPE 1434

Query: 676  --DGIKSQGGVQGGMVFSI-YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
                  ++G    G  F++ YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1435 SEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 79/311 (25%), Positives = 143/311 (45%), Gaps = 41/311 (13%)

Query: 1234 RRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMV 1293
            RR C   +    F   ++ ++ ++++ +A+E   QPN     V    +     +FT EM+
Sbjct: 514  RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW-LTEVQDTANKALLALFTAEML 572

Query: 1294 IKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRP 1353
            +KM  LGL     AYF  L+N  D  VV G ++            +  I  LR +R+LR 
Sbjct: 573  LKMYSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLG-ISVLRCVRLLRI 627

Query: 1354 LKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEF 1413
             K  +    L  +   ++NS++++ ++L++  LF+ IF+++ +QLF GKF          
Sbjct: 628  FKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF---------- 677

Query: 1414 EKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDAT 1473
                         +E++ R          +DN   +LLT+F + TGE W  V+    D  
Sbjct: 678  -----------NFDEMQTRRST-------FDNFPQSLLTVFQILTGEDWNSVM---YDGI 716

Query: 1474 FENQGPS-PGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNER 1532
                GPS PG  M + I++++ F+   +  +N+F+A+ +    +  + +      E+ E+
Sbjct: 717  MAYGGPSFPG--MLVCIYFIILFICGNYILLNVFLAIAVDNLAD-AESLTSAQKEEEEEK 773

Query: 1533 ACIDFAISAKP 1543
                 A +A P
Sbjct: 774  ERKKLARTASP 784



 Score = 82.0 bits (201), Expect = 6e-15
 Identities = 73/297 (24%), Positives = 130/297 (43%), Gaps = 62/297 (20%)

Query: 1567 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1623
            PFE  I+  I  N + L +        S A  + L     +F  +F++E  LKV+A+G+L
Sbjct: 125  PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1624 ----NYFRDAWNIFDFVTVLGSITDILVTEF----GNNFI-------NLSFLRLFRAARL 1668
                 Y R+ WN+ DF+ V+  +   ++ +     G N +       ++  LR FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1669 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF---------GNIGI 1719
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F            GI
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1720 -DVEDEDSDEDEFQITEH---------------------NNFRTFFQALMLLFRSATGEA 1757
             DV  ED        T H                      NF  F  A++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1758 WHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
            W +++               +    G ++ + YFV+ I + SF +LNL + V+   F
Sbjct: 365  WTDVLY-------------WVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 69/302 (22%), Positives = 118/302 (39%), Gaps = 81/302 (26%)

Query: 100  FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
            FEY++   I+ N I LA++ +            ++     F G+F  E  +K+IA    F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273

Query: 160  HKGSYLRNGWNVMDFVVVLTGILATVGTEFD--------------------LRTLRAVRV 199
                Y  + WN  D ++V+  I+    TE +                    +   R  RV
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333

Query: 200  LRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEE 259
            +R +KL+S    ++ +L + +K+   L  + LL+     I+A+IG++ + GK        
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI------- 1385

Query: 260  GTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEG 319
                      A   T E  R               NN    F     AVL +F+C T E 
Sbjct: 1386 ----------ALNDTTEINR---------------NNNFQTFPQ---AVLLLFRCATGEA 1417

Query: 320  WTDLLY---------------NSNDAS---GNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
            W D++                NS +     G+++   YFI   ++ +F ++NL + V+  
Sbjct: 1418 WQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMD 1477

Query: 362  EF 363
             F
Sbjct: 1478 NF 1479


>gi|193794830 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 10 [Homo sapiens]
          Length = 2155

 Score =  770 bits (1987), Expect = 0.0
 Identities = 405/886 (45%), Positives = 565/886 (63%), Gaps = 73/886 (8%)

Query: 1146 IVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEE 1205
            +V  P+  ++   K   K      + PPA    +N   +Q N+N +  P P  E   +E+
Sbjct: 790  LVEKPAVGESKEEKIELKSITADGESPPATK--INMDDLQPNENEDKSPYPNPETTGEED 847

Query: 1206 EEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLCHYILNLRYFEMCIL 1251
            EE+     GP+P              MP  S+ FI S+ N  R  CH I+N   F   IL
Sbjct: 848  EEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLIL 907

Query: 1252 MVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRD 1311
              I +SSI+LAAEDPVQ  + RN++L   DYVFT +FT E+++KM   G  LH+G++ R+
Sbjct: 908  FFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRN 967

Query: 1312 LWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVV 1371
             +NILD +VVS +L++F    ++    IN +K LRVLRVLRPL+ I R   LK V  CV 
Sbjct: 968  YFNILDLLVVSVSLISFGIQSSA----INVVKILRVLRVLRPLRAINRAKGLKHVVQCVF 1023

Query: 1372 NSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK- 1430
             +++ + NI+IV  L  F+FA + VQLFKGK + C+D SK+ E +C+G Y+ Y+  EV  
Sbjct: 1024 VAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDH 1083

Query: 1431 --ARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMS 1488
               + R W+  +F +DNVL A++ LFTVST EGWP++L  S+D+  E++GP   YR+E+S
Sbjct: 1084 PIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEIS 1143

Query: 1489 IFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHM 1548
            IF+++Y ++  FF +NIFV  +I+TFQEQG++  +   L+KN+R C+++A+ A+PL R++
Sbjct: 1144 IFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYI 1203

Query: 1549 PQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSL 1608
            P+N+   QY++W  V S  FEY +  +I LNTI L M+ YG S  ++ A+ + N++FT L
Sbjct: 1204 PKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGL 1261

Query: 1609 FSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNF-------------- 1654
            F++E +LK++AF    YF D WN+FDF+ V+GSI D++++E  + F              
Sbjct: 1262 FTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVG 1321

Query: 1655 ------------------INLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVC 1696
                              I+++F RLFR  RL+KLL +G  IR LLWTF++SF+ALPYV 
Sbjct: 1322 SIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVA 1381

Query: 1697 LLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGE 1756
            LLI MLFFIYA+IGMQVFG I ++        D  +I  +NNF+TF QA++LLFR ATGE
Sbjct: 1382 LLIVMLFFIYAVIGMQVFGKIALN--------DTTEINRNNNFQTFPQAVLLLFRCATGE 1433

Query: 1757 AWHNIMLSCLSGKPC-----DKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIM 1811
            AW +IML+C+ GK C       NS      CG+ FA FYF+SF  LC+FL++NLFVAVIM
Sbjct: 1434 AWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIM 1493

Query: 1812 DNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPH 1871
            DNF+YLTRD SILGPHHLDE+ R+WAEYDP A GRI + D+ +LLR I PPLG GK CPH
Sbjct: 1494 DNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPH 1553

Query: 1872 RVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIW 1931
            RVACKRL+ M++P+  D TV FN+TL AL+RTAL IK      + +Q + ELR  +  IW
Sbjct: 1554 RVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTE---GNLEQANEELRAIIKKIW 1610

Query: 1932 PNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAM 1977
               S K LD +V P    ++TVGK YA  +I EY+R+ K +K Q +
Sbjct: 1611 KRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGL 1656



 Score =  671 bits (1730), Expect = 0.0
 Identities = 383/827 (46%), Positives = 507/827 (61%), Gaps = 64/827 (7%)

Query: 2   ARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQG-----------GQPGAQRMYKQ 50
           + +G   PA +    + AAAG+        GA  S Q            G  G   +   
Sbjct: 18  SNYGSPRPA-HANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTV 76

Query: 51  SMAQRARTMALYNPIPVRQNCLTVNR---SLFLFSEDNVVRKYAKKITEWPPFEYMILAT 107
           S  QR R    Y   P +Q   T  R   +L   +  N +R+    I EW PFE +IL T
Sbjct: 77  SSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLT 133

Query: 108 IIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRN 167
           I ANC+ LA+    P+DD    +  L+  E  F+ IF  EA +K+IA G  FH  +YLRN
Sbjct: 134 IFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRN 193

Query: 168 GWNVMDFVVVLTGILATV----------------GTEFDLRTLRAVRVLRPLKLVSGIPS 211
           GWN++DF++V+ G+ + +                G  FD++ LRA RVLRPL+LVSG+PS
Sbjct: 194 GWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPS 253

Query: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF-EEGTDDIQGES-P 269
           LQVVL SI+KAM+PLL I LL+ F I+I+AIIGLE +MGK H TC+ +EG  D+  E  P
Sbjct: 254 LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 270 APCGTEEP-ARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSN 328
           +PC  E    R C NGT C+P W+GP +GIT FDN  FA+LTVFQCITMEGWTD+LY  N
Sbjct: 314 SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 329 DASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 388
           DA G  W W+YF+ LIIIGSFF+LNLVLGVLSGEF+KERE+ + R  F KLR +QQ+E +
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433

Query: 389 LNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIAS 448
           L GY++WI++AE++    ++   ++  P     R  ++  S+T+ +N E       +  +
Sbjct: 434 LKGYLDWITQAEDIDPENEDEGMDEEKP-----RNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 449 VGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH 508
            G   AR + + +K + S ++ +  R  R   R  VK+  FYW V+ LV LNTL +A  H
Sbjct: 489 CG---ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEH 545

Query: 509 YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIW 568
           YNQP WL++    A    L LF +EM +KMY LG + YF S FN FDC V+ G I E I 
Sbjct: 546 YNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETIL 605

Query: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
              K  +  GISVLR +RLLRIFK+T+YW SL NLV SLLNS++SI SLL LLFLFI++F
Sbjct: 606 VETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIF 665

Query: 629 ALLGMQLFGGQFNFDE-GTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQ-G 686
           +LLGMQLFGG+FNFDE  T  + FD FP +++TVFQILTGEDWN VMYDGI + GG    
Sbjct: 666 SLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 687 GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEV 746
           GM+  IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EEEE   +K         
Sbjct: 726 GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERK--------- 776

Query: 747 AEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREA 793
                   A  +   K+Q+  +KPA  V E +  ++  +++ A  E+
Sbjct: 777 ------KLARTASPEKKQELVEKPA--VGESKEEKIELKSITADGES 815



 Score =  202 bits (513), Expect = 4e-51
 Identities = 176/705 (24%), Positives = 317/705 (44%), Gaps = 120/705 (17%)

Query: 1200 EEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSI 1259
            + K+++    + +       P  ++  L+  NP+RR C  I+  + FE+ IL+ I  + +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1260 ALAAEDPV---QPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNIL 1316
            ALA   P      NA  +N+ R  +Y+F  +FT E  +K+I  GL+ H  AY R+ WN+L
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV-EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198

Query: 1317 DFIVVSGALVAFAFTGNSKGKDINT---------IKSLRVLRVLRPLKTIKRLPKLKAVF 1367
            DFI+V   L +      +K    N          +K+LR  RVLRPL+ +  +P L+ V 
Sbjct: 199  DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258

Query: 1368 DCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC---------- 1417
            + ++ ++  + +I ++ +  + I+A++ ++LF GK  H T  ++E   D           
Sbjct: 259  NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK-MHKTCYNQEGIADVPAEDDPSPCA 317

Query: 1418 --RGKYLLYEKNEVKARDREWKKYEF-HYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
               G     +   V     +  K+   ++DN  +A+LT+F   T EGW  VL    DA  
Sbjct: 318  LETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAV- 376

Query: 1475 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KMMEEY 1525
                     R    I++V   ++  FF +N+ + ++   F ++       GD  K+ E+ 
Sbjct: 377  --------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428

Query: 1526 SLEKNERACIDFAISA---------------KPLTRHMP--------------------- 1549
             LE++ +  +D+   A               KP    MP                     
Sbjct: 429  QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 1550 ----------QNKQSFQYRMWQ---------FVVSPPFEYTIMAMIALNTIVLMMKFYGA 1590
                      ++K S  +R W           V S  F + ++ ++ LNT+ +  + Y  
Sbjct: 489  CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548

Query: 1591 SVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITD-ILVTE 1649
                       N    +LF+ E +LK+ + G+  YF   +N FD   V G I + ILV  
Sbjct: 549  PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 1650 FGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAII 1709
               + + +S LR  R  R+ K+ R   ++  L+ + + S +++  + LL+ +   I++++
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 1710 GMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGK 1769
            GMQ+FG           + DE Q T  + F  F Q+L+ +F+  TGE W+++M   +   
Sbjct: 669  GMQLFGG--------KFNFDEMQ-TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAY 719

Query: 1770 PCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
                  G+L           YF+  +F+C ++++LN+F+A+ +DN
Sbjct: 720  GGPSFPGML--------VCIYFI-ILFICGNYILLNVFLAIAVDN 755



 Score =  143 bits (360), Expect = 2e-33
 Identities = 179/785 (22%), Positives = 325/785 (41%), Gaps = 161/785 (20%)

Query: 33   AGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAK 92
            AGG  +G   GA+  ++ S ++ +R    +N    R+ C    +S       NV      
Sbjct: 480  AGGDIEGENCGARLAHRISKSKFSRYWRRWNRF-CRRKCRAAVKS-------NV------ 525

Query: 93   KITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKI 152
                   F ++++  +  N + +A E +   +    ++E  D      + +F  E  +K+
Sbjct: 526  -------FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKM 575

Query: 153  IALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------FDLRTLRAVRVLRPLKLV 206
             +LG      +Y  + +N  D  VV  GIL T+  E        +  LR VR+LR  K+ 
Sbjct: 576  YSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKIT 631

Query: 207  SGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQG 266
                SL  ++ S++ ++  +  + LLLF  I+IF+++G++ + GKF+        D++Q 
Sbjct: 632  RYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF-------DEMQT 684

Query: 267  ESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYN 326
                                            + FDN   ++LTVFQ +T E W  ++Y+
Sbjct: 685  RR------------------------------STFDNFPQSLLTVFQILTGEDWNSVMYD 714

Query: 327  SNDASGNT-----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERE 368
               A G          +YFI L I G++ +LN+ L +     A             +E+E
Sbjct: 715  GIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKE 774

Query: 369  RVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIK- 427
            R +  R     ++Q+ +E+   G     SK E++ L     DGE   P    +    ++ 
Sbjct: 775  RKKLARTASPEKKQELVEKPAVGE----SKEEKIELKSITADGES--PPATKINMDDLQP 828

Query: 428  ---KSKTDLLNPEEA--EDQLADIASVGS---PFARASIKSAKL---ENSTFF-HKKERR 475
               + K+   NPE    ED+      VG    P +   +K   +   E S FF      R
Sbjct: 829  NENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNR 888

Query: 476  MRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ-PEWLSDFLYYAEFIFLGLFMSEM 534
             R    R+V    F   +L  + L+++ +A     Q   + +  L  A+++F  +F  E+
Sbjct: 889  FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEI 948

Query: 535  FIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRI 590
             +KM   G       +  + FN  D  V+  S+       I+      + +LR LR+LR 
Sbjct: 949  ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRP 1005

Query: 591  FKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQ-FNFDEGTPPT 649
             +       L+++V  +  ++++I +++ +  L   +FA +G+QLF G+ +   + +  T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 650  -------------------------------NFDTFPAAIMTVFQILTGEDWNEVMYDGI 678
                                           +FD   AA+M +F + T E W E++Y  I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 679  KSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEA 733
             S    +G +       SI+FI+  +   + ++N+F+   +        +T  EQ E+E 
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEY 1177

Query: 734  ANQKL 738
             N +L
Sbjct: 1178 KNCEL 1182



 Score =  116 bits (291), Expect = 2e-25
 Identities = 96/331 (29%), Positives = 163/331 (49%), Gaps = 33/331 (9%)

Query: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
            + F+FS +N  R    +I     F  +IL  I+ + I LA E   P    +  +  L + 
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILGNA 936

Query: 137  EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV   ++ + G +      ++
Sbjct: 937  DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLI-SFGIQSSAINVVK 995

Query: 193  TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      +FA IG++ + GK 
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 253  HTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----WEGPNNGITQFDNILFA 307
            +T        D   ++ A C  +    T  +G    P      WE   N    FDN+L A
Sbjct: 1056 YT------CSDSSKQTEAEC--KGNYITYKDGEVDHPIIQPRSWE---NSKFDFDNVLAA 1104

Query: 308  VLTVFQCITMEGWTDLLYNSNDA----SGNTWNW-----LYFIPLIIIGSFFMLNLVLGV 358
            ++ +F   T EGW +LLY S D+     G  +N+     ++FI  III +FFM+N+ +G 
Sbjct: 1105 MMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGF 1164

Query: 359  LSGEFAKERERVENRRAFLKLRRQQQIEREL 389
            +   F ++ E+ E +   L   ++Q +E  L
Sbjct: 1165 VIVTFQEQGEQ-EYKNCELDKNQRQCVEYAL 1194



 Score =  107 bits (267), Expect = 1e-22
 Identities = 80/311 (25%), Positives = 142/311 (45%), Gaps = 59/311 (18%)

Query: 472  KERRMRFYIRR---------MVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 522
            K R +R YI +         +V +  F + +  L+ LNT+C+A+ HY Q       +   
Sbjct: 1195 KARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNIL 1254

Query: 523  EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVI-----------W--- 568
              +F GLF  EM +K+     + YF   +N FD  ++IGSI +VI           W   
Sbjct: 1255 NMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTF 1314

Query: 569  -AVIKPGTSFGISV----------------LRALRLLRIFKVTKYWASLRNLVVSLLNSM 611
             A+I  G+   I++                 R  R++R+ K+      +R L+ + + S 
Sbjct: 1315 DALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSF 1374

Query: 612  KSIISLLFLLFLFIVVFALLGMQLFG--GQFNFDEGTPPTNFDTFPAAIMTVFQILTGED 669
            +++  +  L+ +   ++A++GMQ+FG     +  E     NF TFP A++ +F+  TGE 
Sbjct: 1375 QALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEA 1434

Query: 670  WNEVMY-------------DGIKSQGGVQGGMVFSI-YFIVLTLFGNYTLLNVFLAIAVD 715
            W ++M                  ++G    G  F++ YFI   +   + ++N+F+A+ +D
Sbjct: 1435 WQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMD 1494

Query: 716  NLANAQELTKD 726
            N      LT+D
Sbjct: 1495 NF---DYLTRD 1502



 Score = 82.0 bits (201), Expect = 6e-15
 Identities = 73/297 (24%), Positives = 130/297 (43%), Gaps = 62/297 (20%)

Query: 1567 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1623
            PFE  I+  I  N + L +        S A  + L     +F  +F++E  LKV+A+G+L
Sbjct: 125  PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1624 ----NYFRDAWNIFDFVTVLGSITDILVTEF----GNNFI-------NLSFLRLFRAARL 1668
                 Y R+ WN+ DF+ V+  +   ++ +     G N +       ++  LR FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1669 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF---------GNIGI 1719
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F            GI
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1720 -DVEDEDSDEDEFQITEH---------------------NNFRTFFQALMLLFRSATGEA 1757
             DV  ED        T H                      NF  F  A++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1758 WHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
            W +++               +    G ++ + YFV+ I + SF +LNL + V+   F
Sbjct: 365  WTDVLY-------------WVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408



 Score = 61.6 bits (148), Expect = 8e-09
 Identities = 72/319 (22%), Positives = 122/319 (38%), Gaps = 98/319 (30%)

Query: 100  FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
            FEY++   I+ N I LA++ +            ++     F G+F  E  +K+IA    F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273

Query: 160  HKGSYLRNGWNVMDFVVVLTGILATVGTE-----------FD------------------ 190
                Y  + WNV DF++V+  I+  + +E           FD                  
Sbjct: 1274 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNN 1333

Query: 191  --------LRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAI 242
                    +   R  RV+R +KL+S    ++ +L + +K+   L  + LL+     I+A+
Sbjct: 1334 AEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAV 1393

Query: 243  IGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFD 302
            IG++ + GK                  A   T E  R               NN    F 
Sbjct: 1394 IGMQVF-GKI-----------------ALNDTTEINR---------------NNNFQTFP 1420

Query: 303  NILFAVLTVFQCITMEGWTDLLY---------------NSNDAS---GNTWNWLYFIPLI 344
                AVL +F+C T E W D++                NS +     G+++   YFI   
Sbjct: 1421 Q---AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFY 1477

Query: 345  IIGSFFMLNLVLGVLSGEF 363
            ++ +F ++NL + V+   F
Sbjct: 1478 MLCAFLIINLFVAVIMDNF 1496


>gi|193788526 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 6 [Homo sapiens]
          Length = 2158

 Score =  769 bits (1985), Expect = 0.0
 Identities = 409/889 (46%), Positives = 566/889 (63%), Gaps = 76/889 (8%)

Query: 1146 IVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEE 1205
            +V  P+  ++   K   K      + PPA    +N   +Q N+N +  P P  E   +E+
Sbjct: 790  LVEKPAVGESKEEKIELKSITADGESPPATK--INMDDLQPNENEDKSPYPNPETTGEED 847

Query: 1206 EEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLCHYILNLRYFEMCIL 1251
            EE+     GP+P              MP  S+ FI S+ N  R  CH I+N   F   IL
Sbjct: 848  EEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLIL 907

Query: 1252 MVIAMSSIALAAEDPVQPNAPRNNVLRYFD--------------------YVFTGVFTFE 1291
              I +SSI+LAAEDPVQ  + RN++L YFD                    YVFT +FT E
Sbjct: 908  FFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLE 967

Query: 1292 MVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVL 1351
            +++KM   G  LH+G++ R+ +NILD +VVS +L++F    ++    IN +K LRVLRVL
Sbjct: 968  IILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA----INVVKILRVLRVL 1023

Query: 1352 RPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESK 1411
            RPL+ I R   LK V  CV  +++ + NI+IV  L  F+FA + VQLFKGK + C+D SK
Sbjct: 1024 RPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSK 1083

Query: 1412 EFEKDCRGKYLLYEKNEVK---ARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKH 1468
            + E +C+G Y+ Y+  EV     + R W+  +F +DNVL A++ LFTVST EGWP++L  
Sbjct: 1084 QTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYR 1143

Query: 1469 SVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLE 1528
            S+D+  E++GP   YR+E+SIF+++Y ++  FF +NIFV  +I+TFQEQG++  +   L+
Sbjct: 1144 SIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELD 1203

Query: 1529 KNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFY 1588
            KN+R C+++A+ A+PL R++P+N+   QY++W  V S  FEY +  +I LNTI L M+ Y
Sbjct: 1204 KNQRQCVEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHY 1261

Query: 1589 GASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVT 1648
            G S  ++ A+ + N++FT LF++E +LK++AF   +YF DAWN FD + V+GSI DI +T
Sbjct: 1262 GQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAIT 1321

Query: 1649 EFG---------------NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALP 1693
            E                 N+ I+++F RLFR  RL+KLL +G  IR LLWTF++SF+ALP
Sbjct: 1322 EVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALP 1381

Query: 1694 YVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSA 1753
            YV LLI MLFFIYA+IGMQVFG I ++        D  +I  +NNF+TF QA++LLFR A
Sbjct: 1382 YVALLIVMLFFIYAVIGMQVFGKIALN--------DTTEINRNNNFQTFPQAVLLLFRCA 1433

Query: 1754 TGEAWHNIMLSCLSGKPC-----DKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVA 1808
            TGEAW +IML+C+ GK C       NS      CG+ FA FYF+SF  LC+FL++NLFVA
Sbjct: 1434 TGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVA 1493

Query: 1809 VIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKK 1868
            VIMDNF+YLTRD SILGPHHLDE+ R+WAEYDP A GRI + D+ +LLR I PPLG GK 
Sbjct: 1494 VIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKL 1553

Query: 1869 CPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMM 1928
            CPHRVACKRL+ M++P+  D TV FN+TL AL+RTAL IK      + +Q + ELR  + 
Sbjct: 1554 CPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTE---GNLEQANEELRAIIK 1610

Query: 1929 AIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAM 1977
             IW   S K LD +V P    ++TVGK YA  +I EY+R+ K +K Q +
Sbjct: 1611 KIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGL 1659



 Score =  671 bits (1730), Expect = 0.0
 Identities = 383/827 (46%), Positives = 507/827 (61%), Gaps = 64/827 (7%)

Query: 2   ARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQG-----------GQPGAQRMYKQ 50
           + +G   PA +    + AAAG+        GA  S Q            G  G   +   
Sbjct: 18  SNYGSPRPA-HANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTV 76

Query: 51  SMAQRARTMALYNPIPVRQNCLTVNR---SLFLFSEDNVVRKYAKKITEWPPFEYMILAT 107
           S  QR R    Y   P +Q   T  R   +L   +  N +R+    I EW PFE +IL T
Sbjct: 77  SSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLT 133

Query: 108 IIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRN 167
           I ANC+ LA+    P+DD    +  L+  E  F+ IF  EA +K+IA G  FH  +YLRN
Sbjct: 134 IFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRN 193

Query: 168 GWNVMDFVVVLTGILATV----------------GTEFDLRTLRAVRVLRPLKLVSGIPS 211
           GWN++DF++V+ G+ + +                G  FD++ LRA RVLRPL+LVSG+PS
Sbjct: 194 GWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPS 253

Query: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF-EEGTDDIQGES-P 269
           LQVVL SI+KAM+PLL I LL+ F I+I+AIIGLE +MGK H TC+ +EG  D+  E  P
Sbjct: 254 LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 270 APCGTEEP-ARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSN 328
           +PC  E    R C NGT C+P W+GP +GIT FDN  FA+LTVFQCITMEGWTD+LY  N
Sbjct: 314 SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 329 DASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 388
           DA G  W W+YF+ LIIIGSFF+LNLVLGVLSGEF+KERE+ + R  F KLR +QQ+E +
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433

Query: 389 LNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIAS 448
           L GY++WI++AE++    ++   ++  P     R  ++  S+T+ +N E       +  +
Sbjct: 434 LKGYLDWITQAEDIDPENEDEGMDEEKP-----RNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 449 VGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH 508
            G   AR + + +K + S ++ +  R  R   R  VK+  FYW V+ LV LNTL +A  H
Sbjct: 489 CG---ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEH 545

Query: 509 YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIW 568
           YNQP WL++    A    L LF +EM +KMY LG + YF S FN FDC V+ G I E I 
Sbjct: 546 YNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETIL 605

Query: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
              K  +  GISVLR +RLLRIFK+T+YW SL NLV SLLNS++SI SLL LLFLFI++F
Sbjct: 606 VETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIF 665

Query: 629 ALLGMQLFGGQFNFDE-GTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQ-G 686
           +LLGMQLFGG+FNFDE  T  + FD FP +++TVFQILTGEDWN VMYDGI + GG    
Sbjct: 666 SLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 687 GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEV 746
           GM+  IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EEEE   +K         
Sbjct: 726 GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERK--------- 776

Query: 747 AEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREA 793
                   A  +   K+Q+  +KPA  V E +  ++  +++ A  E+
Sbjct: 777 ------KLARTASPEKKQELVEKPA--VGESKEEKIELKSITADGES 815



 Score =  202 bits (513), Expect = 4e-51
 Identities = 176/705 (24%), Positives = 317/705 (44%), Gaps = 120/705 (17%)

Query: 1200 EEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSI 1259
            + K+++    + +       P  ++  L+  NP+RR C  I+  + FE+ IL+ I  + +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1260 ALAAEDPV---QPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNIL 1316
            ALA   P      NA  +N+ R  +Y+F  +FT E  +K+I  GL+ H  AY R+ WN+L
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV-EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198

Query: 1317 DFIVVSGALVAFAFTGNSKGKDINT---------IKSLRVLRVLRPLKTIKRLPKLKAVF 1367
            DFI+V   L +      +K    N          +K+LR  RVLRPL+ +  +P L+ V 
Sbjct: 199  DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258

Query: 1368 DCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC---------- 1417
            + ++ ++  + +I ++ +  + I+A++ ++LF GK  H T  ++E   D           
Sbjct: 259  NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK-MHKTCYNQEGIADVPAEDDPSPCA 317

Query: 1418 --RGKYLLYEKNEVKARDREWKKYEF-HYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
               G     +   V     +  K+   ++DN  +A+LT+F   T EGW  VL    DA  
Sbjct: 318  LETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAV- 376

Query: 1475 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KMMEEY 1525
                     R    I++V   ++  FF +N+ + ++   F ++       GD  K+ E+ 
Sbjct: 377  --------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428

Query: 1526 SLEKNERACIDFAISA---------------KPLTRHMP--------------------- 1549
             LE++ +  +D+   A               KP    MP                     
Sbjct: 429  QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 1550 ----------QNKQSFQYRMWQ---------FVVSPPFEYTIMAMIALNTIVLMMKFYGA 1590
                      ++K S  +R W           V S  F + ++ ++ LNT+ +  + Y  
Sbjct: 489  CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548

Query: 1591 SVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITD-ILVTE 1649
                       N    +LF+ E +LK+ + G+  YF   +N FD   V G I + ILV  
Sbjct: 549  PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 1650 FGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAII 1709
               + + +S LR  R  R+ K+ R   ++  L+ + + S +++  + LL+ +   I++++
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 1710 GMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGK 1769
            GMQ+FG           + DE Q T  + F  F Q+L+ +F+  TGE W+++M   +   
Sbjct: 669  GMQLFGG--------KFNFDEMQ-TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAY 719

Query: 1770 PCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
                  G+L           YF+  +F+C ++++LN+F+A+ +DN
Sbjct: 720  GGPSFPGML--------VCIYFI-ILFICGNYILLNVFLAIAVDN 755



 Score =  137 bits (344), Expect = 2e-31
 Identities = 181/804 (22%), Positives = 330/804 (41%), Gaps = 179/804 (22%)

Query: 33   AGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAK 92
            AGG  +G   GA+  ++ S ++ +R    +N    R+ C    +S       NV      
Sbjct: 480  AGGDIEGENCGARLAHRISKSKFSRYWRRWNRF-CRRKCRAAVKS-------NV------ 525

Query: 93   KITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKI 152
                   F ++++  +  N + +A E +   +    ++E  D      + +F  E  +K+
Sbjct: 526  -------FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKM 575

Query: 153  IALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------FDLRTLRAVRVLRPLKLV 206
             +LG      +Y  + +N  D  VV  GIL T+  E        +  LR VR+LR  K+ 
Sbjct: 576  YSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKIT 631

Query: 207  SGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQG 266
                SL  ++ S++ ++  +  + LLLF  I+IF+++G++ + GKF+        D++Q 
Sbjct: 632  RYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF-------DEMQT 684

Query: 267  ESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYN 326
                                            + FDN   ++LTVFQ +T E W  ++Y+
Sbjct: 685  RR------------------------------STFDNFPQSLLTVFQILTGEDWNSVMYD 714

Query: 327  SNDASGNT-----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERE 368
               A G          +YFI L I G++ +LN+ L +     A             +E+E
Sbjct: 715  GIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKE 774

Query: 369  RVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIK- 427
            R +  R     ++Q+ +E+   G     SK E++ L     DGE   P    +    ++ 
Sbjct: 775  RKKLARTASPEKKQELVEKPAVGE----SKEEKIELKSITADGES--PPATKINMDDLQP 828

Query: 428  ---KSKTDLLNPEEA--EDQLADIASVGS---PFARASIKSAKL---ENSTFF-HKKERR 475
               + K+   NPE    ED+      VG    P +   +K   +   E S FF      R
Sbjct: 829  NENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNR 888

Query: 476  MRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ-PEWLSDFLYYAEFIFLGLFMSEM 534
             R    R+V    F   +L  + L+++ +A     Q   + +  L+Y + +F  +F  E+
Sbjct: 889  FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEI 948

Query: 535  FIKMYGLGTRPYFHSSFNCFDC-------------GVIIGSIFEVIWAVIKPGT--SFGI 579
             +K+  LG   Y  +S    +              G    + F ++  ++   +  SFGI
Sbjct: 949  ALKI--LGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGI 1006

Query: 580  S--------VLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALL 631
                     +LR LR+LR  +       L+++V  +  ++++I +++ +  L   +FA +
Sbjct: 1007 QSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1066

Query: 632  GMQLFGGQ-FNFDEGTPPT-------------------------------NFDTFPAAIM 659
            G+QLF G+ +   + +  T                               +FD   AA+M
Sbjct: 1067 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1126

Query: 660  TVFQILTGEDWNEVMYDGIKSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAV 714
             +F + T E W E++Y  I S    +G +       SI+FI+  +   + ++N+F+   +
Sbjct: 1127 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1186

Query: 715  DNLANAQELTKDEQEEEEAANQKL 738
                    +T  EQ E+E  N +L
Sbjct: 1187 --------VTFQEQGEQEYKNCEL 1202



 Score =  113 bits (282), Expect = 2e-24
 Identities = 74/294 (25%), Positives = 138/294 (46%), Gaps = 42/294 (14%)

Query: 472  KERRMRFYIRR---------MVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 522
            K R +R YI +         +V +  F + +  L+ LNT+C+A+ HY Q       +   
Sbjct: 1215 KARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNIL 1274

Query: 523  EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKP--------- 573
              +F GLF  EM +K+     + YF  ++N FD  +++GSI ++    + P         
Sbjct: 1275 NMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPS 1334

Query: 574  -----GTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
                  +   I+  R  R++R+ K+      +R L+ + + S +++  +  L+ +   ++
Sbjct: 1335 MNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIY 1394

Query: 629  ALLGMQLFG--GQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMY----------- 675
            A++GMQ+FG     +  E     NF TFP A++ +F+  TGE W ++M            
Sbjct: 1395 AVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPE 1454

Query: 676  --DGIKSQGGVQGGMVFSI-YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
                  ++G    G  F++ YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1455 SEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1505



 Score =  107 bits (266), Expect = 2e-22
 Identities = 97/349 (27%), Positives = 164/349 (46%), Gaps = 49/349 (14%)

Query: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALE---QHLPDDDKTPMS--- 130
            + F+FS +N  R    +I     F  +IL  I+ + I LA E   QH    +        
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDI 938

Query: 131  ------------ERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVL 178
                        + L + +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV 
Sbjct: 939  VFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVS 998

Query: 179  TGILATVGTEFD----LRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLF 234
              ++ + G +      ++ LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++  
Sbjct: 999  VSLI-SFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1057

Query: 235  FAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPY---- 290
                +FA IG++ + GK +T        D   ++ A C  +    T  +G    P     
Sbjct: 1058 LLQFMFACIGVQLFKGKLYT------CSDSSKQTEAEC--KGNYITYKDGEVDHPIIQPR 1109

Query: 291  -WEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDA----SGNTWNW-----LYF 340
             WE   N    FDN+L A++ +F   T EGW +LLY S D+     G  +N+     ++F
Sbjct: 1110 SWE---NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFF 1166

Query: 341  IPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIEREL 389
            I  III +FFM+N+ +G +   F ++ E+ E +   L   ++Q +E  L
Sbjct: 1167 IIYIIIIAFFMMNIFVGFVIVTFQEQGEQ-EYKNCELDKNQRQCVEYAL 1214



 Score = 82.0 bits (201), Expect = 6e-15
 Identities = 73/297 (24%), Positives = 130/297 (43%), Gaps = 62/297 (20%)

Query: 1567 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1623
            PFE  I+  I  N + L +        S A  + L     +F  +F++E  LKV+A+G+L
Sbjct: 125  PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1624 ----NYFRDAWNIFDFVTVLGSITDILVTEF----GNNFI-------NLSFLRLFRAARL 1668
                 Y R+ WN+ DF+ V+  +   ++ +     G N +       ++  LR FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1669 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF---------GNIGI 1719
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F            GI
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1720 -DVEDEDSDEDEFQITEH---------------------NNFRTFFQALMLLFRSATGEA 1757
             DV  ED        T H                      NF  F  A++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1758 WHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
            W +++               +    G ++ + YFV+ I + SF +LNL + V+   F
Sbjct: 365  WTDVLY-------------WVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 69/302 (22%), Positives = 118/302 (39%), Gaps = 81/302 (26%)

Query: 100  FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
            FEY++   I+ N I LA++ +            ++     F G+F  E  +K+IA    F
Sbjct: 1241 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1293

Query: 160  HKGSYLRNGWNVMDFVVVLTGILATVGTEFD--------------------LRTLRAVRV 199
                Y  + WN  D ++V+  I+    TE +                    +   R  RV
Sbjct: 1294 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1353

Query: 200  LRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEE 259
            +R +KL+S    ++ +L + +K+   L  + LL+     I+A+IG++ + GK        
Sbjct: 1354 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI------- 1405

Query: 260  GTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEG 319
                      A   T E  R               NN    F     AVL +F+C T E 
Sbjct: 1406 ----------ALNDTTEINR---------------NNNFQTFPQ---AVLLLFRCATGEA 1437

Query: 320  WTDLLY---------------NSNDAS---GNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
            W D++                NS +     G+++   YFI   ++ +F ++NL + V+  
Sbjct: 1438 WQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMD 1497

Query: 362  EF 363
             F
Sbjct: 1498 NF 1499


>gi|193788732 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 5 [Homo sapiens]
          Length = 2166

 Score =  766 bits (1979), Expect = 0.0
 Identities = 406/897 (45%), Positives = 565/897 (62%), Gaps = 84/897 (9%)

Query: 1146 IVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEE 1205
            +V  P+  ++   K   K      + PPA    +N   +Q N+N +  P P  E   +E+
Sbjct: 790  LVEKPAVGESKEEKIELKSITADGESPPATK--INMDDLQPNENEDKSPYPNPETTGEED 847

Query: 1206 EEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLCHYILNLRYFEMCIL 1251
            EE+     GP+P              MP  S+ FI S+ N  R  CH I+N   F   IL
Sbjct: 848  EEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLIL 907

Query: 1252 MVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRD 1311
              I +SSI+LAAEDPVQ  + RN++L YFD VFT +FT E+ +KM   G  LH+G++ R+
Sbjct: 908  FFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRN 967

Query: 1312 LWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVV 1371
             +NILD +VVS +L++F    ++    IN +K LRVLRVLRPL+ I R   LK V  CV 
Sbjct: 968  YFNILDLLVVSVSLISFGIQSSA----INVVKILRVLRVLRPLRAINRAKGLKHVVQCVF 1023

Query: 1372 NSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK- 1430
             +++ + NI+IV  L  F+FA + VQLFKGK + C+D SK+ E +C+G Y+ Y+  EV  
Sbjct: 1024 VAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDH 1083

Query: 1431 --ARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMS 1488
               + R W+  +F +DNVL A++ LFTVST EGWP++L  S+D+  E++GP   YR+E+S
Sbjct: 1084 PIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEIS 1143

Query: 1489 IFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHM 1548
            IF+++Y ++  FF +NIFV  +I+TFQEQG++  +   L+KN+R C+++A+ A+PL R++
Sbjct: 1144 IFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYI 1203

Query: 1549 PQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSL 1608
            P+N+   QY++W  V S  FEY +  +I LNTI L M+ YG S  ++ A+ + N++FT L
Sbjct: 1204 PKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGL 1261

Query: 1609 FSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNF-------------- 1654
            F++E +LK++AF    YF D WN+FDF+ V+GSI D++++E  + F              
Sbjct: 1262 FTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVG 1321

Query: 1655 -----------------------------INLSFLRLFRAARLIKLLRQGYTIRILLWTF 1685
                                         I+++F RLFR  RL+KLL +G  IR LLWTF
Sbjct: 1322 SIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTF 1381

Query: 1686 VQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQA 1745
            ++SF+ALPYV LLI MLFFIYA+IGMQVFG I ++        D  +I  +NNF+TF QA
Sbjct: 1382 IKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALN--------DTTEINRNNNFQTFPQA 1433

Query: 1746 LMLLFRSATGEAWHNIMLSCLSGKPC-----DKNSGILTRECGNEFAYFYFVSFIFLCSF 1800
            ++LLFR ATGEAW +IML+C+ GK C       NS      CG+ FA FYF+SF  LC+F
Sbjct: 1434 VLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAF 1493

Query: 1801 LMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVIS 1860
            L++NLFVAVIMDNF+YLTRD SILGPHHLDE+ R+WAEYDP A GRI + D+ +LLR I 
Sbjct: 1494 LIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQ 1553

Query: 1861 PPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMD 1920
            PPLG GK CPHRVACKRL+ M++P+  D TV FN+TL AL+RTAL IK      + +Q +
Sbjct: 1554 PPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTE---GNLEQAN 1610

Query: 1921 AELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAM 1977
             ELR  +  IW   S K LD +V P    ++TVGK YA  +I EY+R+ K +K Q +
Sbjct: 1611 EELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGL 1667



 Score =  671 bits (1730), Expect = 0.0
 Identities = 383/827 (46%), Positives = 507/827 (61%), Gaps = 64/827 (7%)

Query: 2   ARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQG-----------GQPGAQRMYKQ 50
           + +G   PA +    + AAAG+        GA  S Q            G  G   +   
Sbjct: 18  SNYGSPRPA-HANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTV 76

Query: 51  SMAQRARTMALYNPIPVRQNCLTVNR---SLFLFSEDNVVRKYAKKITEWPPFEYMILAT 107
           S  QR R    Y   P +Q   T  R   +L   +  N +R+    I EW PFE +IL T
Sbjct: 77  SSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLT 133

Query: 108 IIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRN 167
           I ANC+ LA+    P+DD    +  L+  E  F+ IF  EA +K+IA G  FH  +YLRN
Sbjct: 134 IFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRN 193

Query: 168 GWNVMDFVVVLTGILATV----------------GTEFDLRTLRAVRVLRPLKLVSGIPS 211
           GWN++DF++V+ G+ + +                G  FD++ LRA RVLRPL+LVSG+PS
Sbjct: 194 GWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPS 253

Query: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF-EEGTDDIQGES-P 269
           LQVVL SI+KAM+PLL I LL+ F I+I+AIIGLE +MGK H TC+ +EG  D+  E  P
Sbjct: 254 LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 270 APCGTEEP-ARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSN 328
           +PC  E    R C NGT C+P W+GP +GIT FDN  FA+LTVFQCITMEGWTD+LY  N
Sbjct: 314 SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 329 DASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 388
           DA G  W W+YF+ LIIIGSFF+LNLVLGVLSGEF+KERE+ + R  F KLR +QQ+E +
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433

Query: 389 LNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIAS 448
           L GY++WI++AE++    ++   ++  P     R  ++  S+T+ +N E       +  +
Sbjct: 434 LKGYLDWITQAEDIDPENEDEGMDEEKP-----RNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 449 VGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH 508
            G   AR + + +K + S ++ +  R  R   R  VK+  FYW V+ LV LNTL +A  H
Sbjct: 489 CG---ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEH 545

Query: 509 YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIW 568
           YNQP WL++    A    L LF +EM +KMY LG + YF S FN FDC V+ G I E I 
Sbjct: 546 YNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETIL 605

Query: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
              K  +  GISVLR +RLLRIFK+T+YW SL NLV SLLNS++SI SLL LLFLFI++F
Sbjct: 606 VETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIF 665

Query: 629 ALLGMQLFGGQFNFDE-GTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQ-G 686
           +LLGMQLFGG+FNFDE  T  + FD FP +++TVFQILTGEDWN VMYDGI + GG    
Sbjct: 666 SLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 687 GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEV 746
           GM+  IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EEEE   +K         
Sbjct: 726 GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERK--------- 776

Query: 747 AEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREA 793
                   A  +   K+Q+  +KPA  V E +  ++  +++ A  E+
Sbjct: 777 ------KLARTASPEKKQELVEKPA--VGESKEEKIELKSITADGES 815



 Score =  202 bits (513), Expect = 4e-51
 Identities = 176/705 (24%), Positives = 317/705 (44%), Gaps = 120/705 (17%)

Query: 1200 EEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSI 1259
            + K+++    + +       P  ++  L+  NP+RR C  I+  + FE+ IL+ I  + +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1260 ALAAEDPV---QPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNIL 1316
            ALA   P      NA  +N+ R  +Y+F  +FT E  +K+I  GL+ H  AY R+ WN+L
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV-EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198

Query: 1317 DFIVVSGALVAFAFTGNSKGKDINT---------IKSLRVLRVLRPLKTIKRLPKLKAVF 1367
            DFI+V   L +      +K    N          +K+LR  RVLRPL+ +  +P L+ V 
Sbjct: 199  DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258

Query: 1368 DCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC---------- 1417
            + ++ ++  + +I ++ +  + I+A++ ++LF GK  H T  ++E   D           
Sbjct: 259  NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK-MHKTCYNQEGIADVPAEDDPSPCA 317

Query: 1418 --RGKYLLYEKNEVKARDREWKKYEF-HYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
               G     +   V     +  K+   ++DN  +A+LT+F   T EGW  VL    DA  
Sbjct: 318  LETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAV- 376

Query: 1475 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KMMEEY 1525
                     R    I++V   ++  FF +N+ + ++   F ++       GD  K+ E+ 
Sbjct: 377  --------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428

Query: 1526 SLEKNERACIDFAISA---------------KPLTRHMP--------------------- 1549
             LE++ +  +D+   A               KP    MP                     
Sbjct: 429  QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 1550 ----------QNKQSFQYRMWQ---------FVVSPPFEYTIMAMIALNTIVLMMKFYGA 1590
                      ++K S  +R W           V S  F + ++ ++ LNT+ +  + Y  
Sbjct: 489  CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548

Query: 1591 SVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITD-ILVTE 1649
                       N    +LF+ E +LK+ + G+  YF   +N FD   V G I + ILV  
Sbjct: 549  PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 1650 FGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAII 1709
               + + +S LR  R  R+ K+ R   ++  L+ + + S +++  + LL+ +   I++++
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 1710 GMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGK 1769
            GMQ+FG           + DE Q T  + F  F Q+L+ +F+  TGE W+++M   +   
Sbjct: 669  GMQLFGG--------KFNFDEMQ-TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAY 719

Query: 1770 PCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
                  G+L           YF+  +F+C ++++LN+F+A+ +DN
Sbjct: 720  GGPSFPGML--------VCIYFI-ILFICGNYILLNVFLAIAVDN 755



 Score =  144 bits (362), Expect = 1e-33
 Identities = 179/785 (22%), Positives = 325/785 (41%), Gaps = 161/785 (20%)

Query: 33   AGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAK 92
            AGG  +G   GA+  ++ S ++ +R    +N    R+ C    +S       NV      
Sbjct: 480  AGGDIEGENCGARLAHRISKSKFSRYWRRWNRF-CRRKCRAAVKS-------NV------ 525

Query: 93   KITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKI 152
                   F ++++  +  N + +A E +   +    ++E  D      + +F  E  +K+
Sbjct: 526  -------FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKM 575

Query: 153  IALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------FDLRTLRAVRVLRPLKLV 206
             +LG      +Y  + +N  D  VV  GIL T+  E        +  LR VR+LR  K+ 
Sbjct: 576  YSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKIT 631

Query: 207  SGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQG 266
                SL  ++ S++ ++  +  + LLLF  I+IF+++G++ + GKF+        D++Q 
Sbjct: 632  RYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF-------DEMQT 684

Query: 267  ESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYN 326
                                            + FDN   ++LTVFQ +T E W  ++Y+
Sbjct: 685  RR------------------------------STFDNFPQSLLTVFQILTGEDWNSVMYD 714

Query: 327  SNDASGNT-----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERE 368
               A G          +YFI L I G++ +LN+ L +     A             +E+E
Sbjct: 715  GIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKE 774

Query: 369  RVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIK- 427
            R +  R     ++Q+ +E+   G     SK E++ L     DGE   P    +    ++ 
Sbjct: 775  RKKLARTASPEKKQELVEKPAVGE----SKEEKIELKSITADGES--PPATKINMDDLQP 828

Query: 428  ---KSKTDLLNPEEA--EDQLADIASVGS---PFARASIKSAKL---ENSTFF-HKKERR 475
               + K+   NPE    ED+      VG    P +   +K   +   E S FF      R
Sbjct: 829  NENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNR 888

Query: 476  MRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ-PEWLSDFLYYAEFIFLGLFMSEM 534
             R    R+V    F   +L  + L+++ +A     Q   + +  L+Y + +F  +F  E+
Sbjct: 889  FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEI 948

Query: 535  FIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRI 590
             +KM   G       +  + FN  D  V+  S+       I+      + +LR LR+LR 
Sbjct: 949  ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRP 1005

Query: 591  FKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQ-FNFDEGTPPT 649
             +       L+++V  +  ++++I +++ +  L   +FA +G+QLF G+ +   + +  T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 650  -------------------------------NFDTFPAAIMTVFQILTGEDWNEVMYDGI 678
                                           +FD   AA+M +F + T E W E++Y  I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 679  KSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEA 733
             S    +G +       SI+FI+  +   + ++N+F+   +        +T  EQ E+E 
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEY 1177

Query: 734  ANQKL 738
             N +L
Sbjct: 1178 KNCEL 1182



 Score =  114 bits (285), Expect = 1e-24
 Identities = 96/331 (29%), Positives = 162/331 (48%), Gaps = 33/331 (9%)

Query: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
            + F+FS +N  R    +I     F  +IL  I+ + I LA E   P    +  +  L   
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 936

Query: 137  EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV   ++ + G +      ++
Sbjct: 937  DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLI-SFGIQSSAINVVK 995

Query: 193  TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      +FA IG++ + GK 
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 253  HTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----WEGPNNGITQFDNILFA 307
            +T        D   ++ A C  +    T  +G    P      WE   N    FDN+L A
Sbjct: 1056 YT------CSDSSKQTEAEC--KGNYITYKDGEVDHPIIQPRSWE---NSKFDFDNVLAA 1104

Query: 308  VLTVFQCITMEGWTDLLYNSNDA----SGNTWNW-----LYFIPLIIIGSFFMLNLVLGV 358
            ++ +F   T EGW +LLY S D+     G  +N+     ++FI  III +FFM+N+ +G 
Sbjct: 1105 MMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGF 1164

Query: 359  LSGEFAKERERVENRRAFLKLRRQQQIEREL 389
            +   F ++ E+ E +   L   ++Q +E  L
Sbjct: 1165 VIVTFQEQGEQ-EYKNCELDKNQRQCVEYAL 1194



 Score =  103 bits (256), Expect = 3e-21
 Identities = 80/322 (24%), Positives = 142/322 (44%), Gaps = 70/322 (21%)

Query: 472  KERRMRFYIRR---------MVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 522
            K R +R YI +         +V +  F + +  L+ LNT+C+A+ HY Q       +   
Sbjct: 1195 KARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNIL 1254

Query: 523  EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVI-----------W--- 568
              +F GLF  EM +K+     + YF   +N FD  ++IGSI +VI           W   
Sbjct: 1255 NMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTF 1314

Query: 569  -AVIKPGTSFGISV---------------------------LRALRLLRIFKVTKYWASL 600
             A+I  G+   I++                            R  R++R+ K+      +
Sbjct: 1315 DALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGI 1374

Query: 601  RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG--GQFNFDEGTPPTNFDTFPAAI 658
            R L+ + + S +++  +  L+ +   ++A++GMQ+FG     +  E     NF TFP A+
Sbjct: 1375 RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAV 1434

Query: 659  MTVFQILTGEDWNEVMY-------------DGIKSQGGVQGGMVFSI-YFIVLTLFGNYT 704
            + +F+  TGE W ++M                  ++G    G  F++ YFI   +   + 
Sbjct: 1435 LLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFL 1494

Query: 705  LLNVFLAIAVDNLANAQELTKD 726
            ++N+F+A+ +DN      LT+D
Sbjct: 1495 IINLFVAVIMDNF---DYLTRD 1513



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 79/311 (25%), Positives = 143/311 (45%), Gaps = 41/311 (13%)

Query: 1234 RRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMV 1293
            RR C   +    F   ++ ++ ++++ +A+E   QPN     V    +     +FT EM+
Sbjct: 514  RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW-LTEVQDTANKALLALFTAEML 572

Query: 1294 IKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRP 1353
            +KM  LGL     AYF  L+N  D  VV G ++            +  I  LR +R+LR 
Sbjct: 573  LKMYSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLG-ISVLRCVRLLRI 627

Query: 1354 LKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEF 1413
             K  +    L  +   ++NS++++ ++L++  LF+ IF+++ +QLF GKF          
Sbjct: 628  FKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF---------- 677

Query: 1414 EKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDAT 1473
                         +E++ R          +DN   +LLT+F + TGE W  V+    D  
Sbjct: 678  -----------NFDEMQTRRST-------FDNFPQSLLTVFQILTGEDWNSVM---YDGI 716

Query: 1474 FENQGPS-PGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNER 1532
                GPS PG  M + I++++ F+   +  +N+F+A+ +    +  + +      E+ E+
Sbjct: 717  MAYGGPSFPG--MLVCIYFIILFICGNYILLNVFLAIAVDNLAD-AESLTSAQKEEEEEK 773

Query: 1533 ACIDFAISAKP 1543
                 A +A P
Sbjct: 774  ERKKLARTASP 784



 Score = 82.0 bits (201), Expect = 6e-15
 Identities = 73/297 (24%), Positives = 130/297 (43%), Gaps = 62/297 (20%)

Query: 1567 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1623
            PFE  I+  I  N + L +        S A  + L     +F  +F++E  LKV+A+G+L
Sbjct: 125  PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1624 ----NYFRDAWNIFDFVTVLGSITDILVTEF----GNNFI-------NLSFLRLFRAARL 1668
                 Y R+ WN+ DF+ V+  +   ++ +     G N +       ++  LR FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1669 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF---------GNIGI 1719
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F            GI
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1720 -DVEDEDSDEDEFQITEH---------------------NNFRTFFQALMLLFRSATGEA 1757
             DV  ED        T H                      NF  F  A++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1758 WHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
            W +++               +    G ++ + YFV+ I + SF +LNL + V+   F
Sbjct: 365  WTDVLY-------------WVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408



 Score = 57.4 bits (137), Expect = 2e-07
 Identities = 72/330 (21%), Positives = 122/330 (36%), Gaps = 109/330 (33%)

Query: 100  FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
            FEY++   I+ N I LA++ +            ++     F G+F  E  +K+IA    F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273

Query: 160  HKGSYLRNGWNVMDFVVVLTGILATVGTE-----------FD------------------ 190
                Y  + WNV DF++V+  I+  + +E           FD                  
Sbjct: 1274 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNP 1333

Query: 191  -------------------LRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGL 231
                               +   R  RV+R +KL+S    ++ +L + +K+   L  + L
Sbjct: 1334 AEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1393

Query: 232  LLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYW 291
            L+     I+A+IG++ + GK                  A   T E  R            
Sbjct: 1394 LIVMLFFIYAVIGMQVF-GKI-----------------ALNDTTEINR------------ 1423

Query: 292  EGPNNGITQFDNILFAVLTVFQCITMEGWTDLLY---------------NSNDAS---GN 333
               NN    F     AVL +F+C T E W D++                NS +     G+
Sbjct: 1424 ---NNNFQTFPQ---AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGS 1477

Query: 334  TWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 363
            ++   YFI   ++ +F ++NL + V+   F
Sbjct: 1478 SFAVFYFISFYMLCAFLIINLFVAVIMDNF 1507


>gi|193788728 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 3 [Homo sapiens]
          Length = 2179

 Score =  765 bits (1976), Expect = 0.0
 Identities = 411/907 (45%), Positives = 568/907 (62%), Gaps = 91/907 (10%)

Query: 1146 IVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEE 1205
            +V  P+  ++   K   K      + PPA    +N   +Q N+N +  P P  E   +E+
Sbjct: 790  LVEKPAVGESKEEKIELKSITADGESPPATK--INMDDLQPNENEDKSPYPNPETTGEED 847

Query: 1206 EEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLCHYILNLRYFEMCIL 1251
            EE+     GP+P              MP  S+ FI S+ N  R  CH I+N   F   IL
Sbjct: 848  EEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLIL 907

Query: 1252 MVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRD 1311
              I +SSI+LAAEDPVQ  + RN++L YFD VFT +FT E+ +KM   G  LH+G++ R+
Sbjct: 908  FFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRN 967

Query: 1312 LWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVV 1371
             +NILD +VVS +L++F    ++    IN +K LRVLRVLRPL+ I R   LK V  CV 
Sbjct: 968  YFNILDLLVVSVSLISFGIQSSA----INVVKILRVLRVLRPLRAINRAKGLKHVVQCVF 1023

Query: 1372 NSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK- 1430
             +++ + NI+IV  L  F+FA + VQLFKGK + C+D SK+ E +C+G Y+ Y+  EV  
Sbjct: 1024 VAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDH 1083

Query: 1431 --ARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMS 1488
               + R W+  +F +DNVL A++ LFTVST EGWP++L  S+D+  E++GP   YR+E+S
Sbjct: 1084 PIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEIS 1143

Query: 1489 IFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHM 1548
            IF+++Y ++  FF +NIFV  +I+TFQEQG++  +   L+KN+R C+++A+ A+PL R++
Sbjct: 1144 IFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYI 1203

Query: 1549 PQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSL 1608
            P+N+   QY++W  V S  FEY +  +I LNTI L M+ YG S  ++ A+ + N++FT L
Sbjct: 1204 PKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGL 1261

Query: 1609 FSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFG----------------- 1651
            F++E +LK++AF   +YF DAWN FD + V+GSI DI +TE                   
Sbjct: 1262 FTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMGPSCSH 1321

Query: 1652 --------------------NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKA 1691
                                N+ I+++F RLFR  RL+KLL +G  IR LLWTF++SF+A
Sbjct: 1322 PPLAVLTAPPVADGFQNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1381

Query: 1692 LPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFR 1751
            LPYV LLI MLFFIYA+IGMQVFG I ++        D  +I  +NNF+TF QA++LLFR
Sbjct: 1382 LPYVALLIVMLFFIYAVIGMQVFGKIALN--------DTTEINRNNNFQTFPQAVLLLFR 1433

Query: 1752 SATGEAWHNIMLSCLSGKPC-----DKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLF 1806
             ATGEAW +IML+C+ GK C       NS      CG+ FA FYF+SF  LC+FL++NLF
Sbjct: 1434 CATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLF 1493

Query: 1807 VAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLG 1866
            VAVIMDNF+YLTRD SILGPHHLDE+ R+WAEYDP A GRI + D+ +LLR I PPLG G
Sbjct: 1494 VAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFG 1553

Query: 1867 KKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKG--------GADK-- 1916
            K CPHRVACKRL+ M++P+  D TV FN+TL AL+RTAL IK  +G        GA+   
Sbjct: 1554 KLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPF 1613

Query: 1917 ------QQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSK 1970
                  +Q + ELR  +  IW   S K LD +V P    ++TVGK YA  +I EY+R+ K
Sbjct: 1614 RPAGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFK 1673

Query: 1971 AKKLQAM 1977
             +K Q +
Sbjct: 1674 KRKEQGL 1680



 Score =  671 bits (1730), Expect = 0.0
 Identities = 383/827 (46%), Positives = 507/827 (61%), Gaps = 64/827 (7%)

Query: 2   ARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQG-----------GQPGAQRMYKQ 50
           + +G   PA +    + AAAG+        GA  S Q            G  G   +   
Sbjct: 18  SNYGSPRPA-HANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTV 76

Query: 51  SMAQRARTMALYNPIPVRQNCLTVNR---SLFLFSEDNVVRKYAKKITEWPPFEYMILAT 107
           S  QR R    Y   P +Q   T  R   +L   +  N +R+    I EW PFE +IL T
Sbjct: 77  SSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLT 133

Query: 108 IIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRN 167
           I ANC+ LA+    P+DD    +  L+  E  F+ IF  EA +K+IA G  FH  +YLRN
Sbjct: 134 IFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRN 193

Query: 168 GWNVMDFVVVLTGILATV----------------GTEFDLRTLRAVRVLRPLKLVSGIPS 211
           GWN++DF++V+ G+ + +                G  FD++ LRA RVLRPL+LVSG+PS
Sbjct: 194 GWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPS 253

Query: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF-EEGTDDIQGES-P 269
           LQVVL SI+KAM+PLL I LL+ F I+I+AIIGLE +MGK H TC+ +EG  D+  E  P
Sbjct: 254 LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 270 APCGTEEP-ARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSN 328
           +PC  E    R C NGT C+P W+GP +GIT FDN  FA+LTVFQCITMEGWTD+LY  N
Sbjct: 314 SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 329 DASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 388
           DA G  W W+YF+ LIIIGSFF+LNLVLGVLSGEF+KERE+ + R  F KLR +QQ+E +
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433

Query: 389 LNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIAS 448
           L GY++WI++AE++    ++   ++  P     R  ++  S+T+ +N E       +  +
Sbjct: 434 LKGYLDWITQAEDIDPENEDEGMDEEKP-----RNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 449 VGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH 508
            G   AR + + +K + S ++ +  R  R   R  VK+  FYW V+ LV LNTL +A  H
Sbjct: 489 CG---ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEH 545

Query: 509 YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIW 568
           YNQP WL++    A    L LF +EM +KMY LG + YF S FN FDC V+ G I E I 
Sbjct: 546 YNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETIL 605

Query: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
              K  +  GISVLR +RLLRIFK+T+YW SL NLV SLLNS++SI SLL LLFLFI++F
Sbjct: 606 VETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIF 665

Query: 629 ALLGMQLFGGQFNFDE-GTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQ-G 686
           +LLGMQLFGG+FNFDE  T  + FD FP +++TVFQILTGEDWN VMYDGI + GG    
Sbjct: 666 SLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 687 GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEV 746
           GM+  IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EEEE   +K         
Sbjct: 726 GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERK--------- 776

Query: 747 AEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREA 793
                   A  +   K+Q+  +KPA  V E +  ++  +++ A  E+
Sbjct: 777 ------KLARTASPEKKQELVEKPA--VGESKEEKIELKSITADGES 815



 Score =  202 bits (513), Expect = 4e-51
 Identities = 176/705 (24%), Positives = 317/705 (44%), Gaps = 120/705 (17%)

Query: 1200 EEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSI 1259
            + K+++    + +       P  ++  L+  NP+RR C  I+  + FE+ IL+ I  + +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1260 ALAAEDPV---QPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNIL 1316
            ALA   P      NA  +N+ R  +Y+F  +FT E  +K+I  GL+ H  AY R+ WN+L
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV-EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198

Query: 1317 DFIVVSGALVAFAFTGNSKGKDINT---------IKSLRVLRVLRPLKTIKRLPKLKAVF 1367
            DFI+V   L +      +K    N          +K+LR  RVLRPL+ +  +P L+ V 
Sbjct: 199  DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258

Query: 1368 DCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC---------- 1417
            + ++ ++  + +I ++ +  + I+A++ ++LF GK  H T  ++E   D           
Sbjct: 259  NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK-MHKTCYNQEGIADVPAEDDPSPCA 317

Query: 1418 --RGKYLLYEKNEVKARDREWKKYEF-HYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
               G     +   V     +  K+   ++DN  +A+LT+F   T EGW  VL    DA  
Sbjct: 318  LETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAV- 376

Query: 1475 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KMMEEY 1525
                     R    I++V   ++  FF +N+ + ++   F ++       GD  K+ E+ 
Sbjct: 377  --------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428

Query: 1526 SLEKNERACIDFAISA---------------KPLTRHMP--------------------- 1549
             LE++ +  +D+   A               KP    MP                     
Sbjct: 429  QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 1550 ----------QNKQSFQYRMWQ---------FVVSPPFEYTIMAMIALNTIVLMMKFYGA 1590
                      ++K S  +R W           V S  F + ++ ++ LNT+ +  + Y  
Sbjct: 489  CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548

Query: 1591 SVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITD-ILVTE 1649
                       N    +LF+ E +LK+ + G+  YF   +N FD   V G I + ILV  
Sbjct: 549  PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 1650 FGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAII 1709
               + + +S LR  R  R+ K+ R   ++  L+ + + S +++  + LL+ +   I++++
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 1710 GMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGK 1769
            GMQ+FG           + DE Q T  + F  F Q+L+ +F+  TGE W+++M   +   
Sbjct: 669  GMQLFGG--------KFNFDEMQ-TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAY 719

Query: 1770 PCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
                  G+L           YF+  +F+C ++++LN+F+A+ +DN
Sbjct: 720  GGPSFPGML--------VCIYFI-ILFICGNYILLNVFLAIAVDN 755



 Score =  144 bits (362), Expect = 1e-33
 Identities = 179/785 (22%), Positives = 325/785 (41%), Gaps = 161/785 (20%)

Query: 33   AGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAK 92
            AGG  +G   GA+  ++ S ++ +R    +N    R+ C    +S       NV      
Sbjct: 480  AGGDIEGENCGARLAHRISKSKFSRYWRRWNRF-CRRKCRAAVKS-------NV------ 525

Query: 93   KITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKI 152
                   F ++++  +  N + +A E +   +    ++E  D      + +F  E  +K+
Sbjct: 526  -------FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKM 575

Query: 153  IALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------FDLRTLRAVRVLRPLKLV 206
             +LG      +Y  + +N  D  VV  GIL T+  E        +  LR VR+LR  K+ 
Sbjct: 576  YSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKIT 631

Query: 207  SGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQG 266
                SL  ++ S++ ++  +  + LLLF  I+IF+++G++ + GKF+        D++Q 
Sbjct: 632  RYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF-------DEMQT 684

Query: 267  ESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYN 326
                                            + FDN   ++LTVFQ +T E W  ++Y+
Sbjct: 685  RR------------------------------STFDNFPQSLLTVFQILTGEDWNSVMYD 714

Query: 327  SNDASGNT-----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERE 368
               A G          +YFI L I G++ +LN+ L +     A             +E+E
Sbjct: 715  GIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKE 774

Query: 369  RVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIK- 427
            R +  R     ++Q+ +E+   G     SK E++ L     DGE   P    +    ++ 
Sbjct: 775  RKKLARTASPEKKQELVEKPAVGE----SKEEKIELKSITADGES--PPATKINMDDLQP 828

Query: 428  ---KSKTDLLNPEEA--EDQLADIASVGS---PFARASIKSAKL---ENSTFF-HKKERR 475
               + K+   NPE    ED+      VG    P +   +K   +   E S FF      R
Sbjct: 829  NENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNR 888

Query: 476  MRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ-PEWLSDFLYYAEFIFLGLFMSEM 534
             R    R+V    F   +L  + L+++ +A     Q   + +  L+Y + +F  +F  E+
Sbjct: 889  FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEI 948

Query: 535  FIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRI 590
             +KM   G       +  + FN  D  V+  S+       I+      + +LR LR+LR 
Sbjct: 949  ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRP 1005

Query: 591  FKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQ-FNFDEGTPPT 649
             +       L+++V  +  ++++I +++ +  L   +FA +G+QLF G+ +   + +  T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 650  -------------------------------NFDTFPAAIMTVFQILTGEDWNEVMYDGI 678
                                           +FD   AA+M +F + T E W E++Y  I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 679  KSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEA 733
             S    +G +       SI+FI+  +   + ++N+F+   +        +T  EQ E+E 
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEY 1177

Query: 734  ANQKL 738
             N +L
Sbjct: 1178 KNCEL 1182



 Score =  114 bits (285), Expect = 1e-24
 Identities = 96/331 (29%), Positives = 162/331 (48%), Gaps = 33/331 (9%)

Query: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
            + F+FS +N  R    +I     F  +IL  I+ + I LA E   P    +  +  L   
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 936

Query: 137  EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV   ++ + G +      ++
Sbjct: 937  DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLI-SFGIQSSAINVVK 995

Query: 193  TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      +FA IG++ + GK 
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 253  HTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----WEGPNNGITQFDNILFA 307
            +T        D   ++ A C  +    T  +G    P      WE   N    FDN+L A
Sbjct: 1056 YT------CSDSSKQTEAEC--KGNYITYKDGEVDHPIIQPRSWE---NSKFDFDNVLAA 1104

Query: 308  VLTVFQCITMEGWTDLLYNSNDA----SGNTWNW-----LYFIPLIIIGSFFMLNLVLGV 358
            ++ +F   T EGW +LLY S D+     G  +N+     ++FI  III +FFM+N+ +G 
Sbjct: 1105 MMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGF 1164

Query: 359  LSGEFAKERERVENRRAFLKLRRQQQIEREL 389
            +   F ++ E+ E +   L   ++Q +E  L
Sbjct: 1165 VIVTFQEQGEQ-EYKNCELDKNQRQCVEYAL 1194



 Score =  104 bits (260), Expect = 9e-22
 Identities = 74/316 (23%), Positives = 138/316 (43%), Gaps = 64/316 (20%)

Query: 472  KERRMRFYIRR---------MVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 522
            K R +R YI +         +V +  F + +  L+ LNT+C+A+ HY Q       +   
Sbjct: 1195 KARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNIL 1254

Query: 523  EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPG-------- 574
              +F GLF  EM +K+     + YF  ++N FD  +++GSI ++    + P         
Sbjct: 1255 NMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPS 1314

Query: 575  ----------------------------TSFGISVLRALRLLRIFKVTKYWASLRNLVVS 606
                                        +   I+  R  R++R+ K+      +R L+ +
Sbjct: 1315 MGPSCSHPPLAVLTAPPVADGFQNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWT 1374

Query: 607  LLNSMKSIISLLFLLFLFIVVFALLGMQLFG--GQFNFDEGTPPTNFDTFPAAIMTVFQI 664
             + S +++  +  L+ +   ++A++GMQ+FG     +  E     NF TFP A++ +F+ 
Sbjct: 1375 FIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRC 1434

Query: 665  LTGEDWNEVMY-------------DGIKSQGGVQGGMVFSI-YFIVLTLFGNYTLLNVFL 710
             TGE W ++M                  ++G    G  F++ YFI   +   + ++N+F+
Sbjct: 1435 ATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFV 1494

Query: 711  AIAVDNLANAQELTKD 726
            A+ +DN      LT+D
Sbjct: 1495 AVIMDNF---DYLTRD 1507



 Score = 82.0 bits (201), Expect = 6e-15
 Identities = 73/297 (24%), Positives = 130/297 (43%), Gaps = 62/297 (20%)

Query: 1567 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1623
            PFE  I+  I  N + L +        S A  + L     +F  +F++E  LKV+A+G+L
Sbjct: 125  PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1624 ----NYFRDAWNIFDFVTVLGSITDILVTEF----GNNFI-------NLSFLRLFRAARL 1668
                 Y R+ WN+ DF+ V+  +   ++ +     G N +       ++  LR FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1669 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF---------GNIGI 1719
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F            GI
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1720 -DVEDEDSDEDEFQITEH---------------------NNFRTFFQALMLLFRSATGEA 1757
             DV  ED        T H                      NF  F  A++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1758 WHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
            W +++               +    G ++ + YFV+ I + SF +LNL + V+   F
Sbjct: 365  WTDVLY-------------WVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 69/324 (21%), Positives = 118/324 (36%), Gaps = 103/324 (31%)

Query: 100  FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
            FEY++   I+ N I LA++ +            ++     F G+F  E  +K+IA    F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273

Query: 160  HKGSYLRNGWNVMDFVVVLTGILATVGTEFD----------------------------- 190
                Y  + WN  D ++V+  I+    TE +                             
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMGPSCSHPPLAVLTAPPVA 1333

Query: 191  -------------LRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAI 237
                         +   R  RV+R +KL+S    ++ +L + +K+   L  + LL+    
Sbjct: 1334 DGFQNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLF 1393

Query: 238  LIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNG 297
             I+A+IG++ + GK                  A   T E  R               NN 
Sbjct: 1394 FIYAVIGMQVF-GKI-----------------ALNDTTEINR---------------NNN 1420

Query: 298  ITQFDNILFAVLTVFQCITMEGWTDLLY---------------NSNDAS---GNTWNWLY 339
               F     AVL +F+C T E W D++                NS +     G+++   Y
Sbjct: 1421 FQTFPQ---AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFY 1477

Query: 340  FIPLIIIGSFFMLNLVLGVLSGEF 363
            FI   ++ +F ++NL + V+   F
Sbjct: 1478 FISFYMLCAFLIINLFVAVIMDNF 1501


>gi|53832007 calcium channel, voltage-dependent, L type, alpha 1F
            subunit [Homo sapiens]
          Length = 1977

 Score =  765 bits (1975), Expect = 0.0
 Identities = 413/921 (44%), Positives = 587/921 (63%), Gaps = 69/921 (7%)

Query: 1197 KKEEEKKEEEEDDRGEDG--------PK----PMPPYSSMFILSTTNPLRRLCHYILNLR 1244
            ++EEE++EEEE++ G  G        PK    P+P  S+ F LS TNPLR+ CH +++  
Sbjct: 812  EEEEEEEEEEEEEEGAGGVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTLIHHH 871

Query: 1245 YFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLH 1304
             F   IL+ I +SS++LAAEDP++ ++ RN++L YFDY FT +FT E+++KM   G  LH
Sbjct: 872  VFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLH 931

Query: 1305 QGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLK 1364
            +G++ R  +N+LD +VVS +L++F    ++    I+ +K LRVLRVLRPL+ I R   LK
Sbjct: 932  RGSFCRSWFNMLDLLVVSVSLISFGIHSSA----ISVVKILRVLRVLRPLRAINRAKGLK 987

Query: 1365 AVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLY 1424
             V  CV  +++ + NI+IV  L  F+FA + VQLFKGKF+ CTDE+K   ++C+G +L+Y
Sbjct: 988  HVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVY 1047

Query: 1425 EKNEVK---ARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSP 1481
               +V     R+R W   +F++DNVL A++ LFTVST EGWP +L  ++DA  E+ GP  
Sbjct: 1048 PDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIY 1107

Query: 1482 GYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISA 1541
             YR+E+S+F++VY ++  FF +NIFV  +IITF+ QG++  +   L+KN+R C+++A+ A
Sbjct: 1108 NYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKA 1167

Query: 1542 KPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVF 1601
            +PL R++P+N    QYR+W  V S  FEY +  +I LNT+ L M+ Y  +  +  A+ + 
Sbjct: 1168 QPLRRYIPKNPH--QYRVWATVNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDIL 1225

Query: 1602 NIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGN--------- 1652
            N+VFT LF++E VLK++AF   +YF DAWN FD + V+GSI DI VTE  N         
Sbjct: 1226 NMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSE 1285

Query: 1653 --NFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1710
              + I+++F RLFR  RL+KLL +G  IR LLWTF++SF+ALPYV LLIAM+FFIYA+IG
Sbjct: 1286 DSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIG 1345

Query: 1711 MQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKP 1770
            MQ+FG + +        +D  QI  +NNF+TF QA++LLFR ATGEAW  IML+ L G  
Sbjct: 1346 MQMFGKVAL--------QDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNR 1397

Query: 1771 CDKNSGILTRE---CGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPH 1827
            CD  S     E   CG+ FA  YF+SF  LC+FL++NLFVAVIMDNF+YLTRD SILGPH
Sbjct: 1398 CDPESDFGPGEEFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH 1457

Query: 1828 HLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVAD 1887
            HLDE+ R+W+EYDP A GRI + D+ +LLR I PPLG GK CPHRVACKRL+ M++P+  
Sbjct: 1458 HLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS 1517

Query: 1888 DNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHK 1947
            D TV FN+TL AL+RT+L IK      + +Q + ELR  +  IW  + QK LD ++ P  
Sbjct: 1518 DGTVTFNATLFALVRTSLKIKTE---GNLEQANQELRIVIKKIWKRMKQKLLDEVIPPPD 1574

Query: 1948 STDLTVGKIYAAMMIMEYYRQSKAKK----------------LQA-MREEQDRTPLMFQR 1990
              ++TVGK YA  +I +Y+R+ + +K                LQA +R  QD  P M Q 
Sbjct: 1575 EEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAGLRSLQDLGPEMRQA 1634

Query: 1991 M--EPPSPTQEGGPGQNALPSTQLDPGGALMAHE-SGLKESPSWVTQRAQEMFQKTGTWS 2047
            +  +     +EG  G        L+   A M  + S  + S   V+    +    + ++ 
Sbjct: 1635 LTCDTEEEEEEGQEGVEEEDEKDLETNKATMVSQPSARRGSGISVSLPVGDRLPDSLSFG 1694

Query: 2048 P---EQGPPTDMPNSQPNSQS 2065
            P   ++G PT    S P + S
Sbjct: 1695 PSDDDRGTPTSSQPSVPQAGS 1715



 Score =  614 bits (1584), Expect = e-175
 Identities = 355/825 (43%), Positives = 472/825 (57%), Gaps = 82/825 (9%)

Query: 9   PARYGGGGSGAAAGVVVG-------SGGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMAL 61
           P+   G G G   G+  G       S G  G G  ++  Q    +    + AQR+     
Sbjct: 14  PSPANGAGPGPEWGLCPGPPAVEGESSGASGLGTPKRRNQHSKHKTVAVASAQRSP---- 69

Query: 62  YNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHL 121
                         R+LF  +  N +R+    I EW PF+ +IL TI ANC+ L +    
Sbjct: 70  --------------RALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPF 115

Query: 122 PDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGI 181
           P+DD    +  L+  E  F+ IF  E  +KI+A G   H  +Y+RNGWN++DF++V+ G+
Sbjct: 116 PEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGL 175

Query: 182 LATVGTE-----------------FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMI 224
            + +  +                 FD++ LRA RVLRPL+LVSG+PSL +VL SIMKA++
Sbjct: 176 FSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALV 235

Query: 225 PLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCP-N 283
           PLL I LL+ F I+I+AIIGLE ++G+ H TC+  G+D    E P+PC +    R C  N
Sbjct: 236 PLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLN 295

Query: 284 GTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPL 343
            T+C+  W GPN GIT FDN  FA+LTVFQC+TMEGWTD+LY   DA G    W+YF+ L
Sbjct: 296 QTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPWVYFVSL 355

Query: 344 IIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVI 403
           +I GSFF+LNLVLGVLSGEF+KERE+ + R  F K R +QQ+E +L GY++WI++AEE+ 
Sbjct: 356 VIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWITQAEELD 415

Query: 404 LAEDETD------------------GEQRHPFDGALR------RTTIKKSK------TDL 433
           + +   D                   E  +   G LR      R+T   S       +D 
Sbjct: 416 MEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRSTHSTSSHASLPASDT 475

Query: 434 LNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTV 493
            +  E +    +     +   R   K  K        +  R +R   RR VK+ A YW V
Sbjct: 476 GSMTETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRARCRRAVKSNACYWAV 535

Query: 494 LSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNC 553
           L LV LNTL +A  H+ QP WL+    YA  + L LF  EM +K+YGLG   Y  S FN 
Sbjct: 536 LLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNR 595

Query: 554 FDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKS 613
           FDC V+ G I E     +      GISVLR +RLLRIFKVT++WASL NLV SLLNSMKS
Sbjct: 596 FDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKS 655

Query: 614 IISLLFLLFLFIVVFALLGMQLFGGQFNFDE-GTPPTNFDTFPAAIMTVFQILTGEDWNE 672
           I SLL LLFLFI++F+LLGMQLFGG+FNFD+  T  + FDTFP A++TVFQILTGEDWN 
Sbjct: 656 IASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQALLTVFQILTGEDWNV 715

Query: 673 VMYDGIKSQGG-VQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELT------- 724
           VMYDGI + GG    GM+  IYFI+L + GNY LLNVFLAIAVDNLA+    T       
Sbjct: 716 VMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDAGTAKDKGGE 775

Query: 725 KDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQK 769
           K  +++    N+ L     KE  E +    A+M    +E+++ ++
Sbjct: 776 KSNEKDLPQENEGLVPGVEKEEEEGARREGADMEEEEEEEEEEEE 820



 Score =  139 bits (350), Expect = 3e-32
 Identities = 107/361 (29%), Positives = 174/361 (48%), Gaps = 46/361 (12%)

Query: 1223 SMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPR--NNVLRYF 1280
            ++F L+  NPLRR C  I+  + F++ IL+ I  + +AL    P   +     N+ L   
Sbjct: 71   ALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQV 130

Query: 1281 DYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAF---------- 1330
            +YVF  +FT E V+K++  GLVLH  AY R+ WN+LDFI+V   L +             
Sbjct: 131  EYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDA 190

Query: 1331 --TGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFM 1388
              TG   G     +K+LR  RVLRPL+ +  +P L  V + ++ +L  + +I ++ +  +
Sbjct: 191  PHTGGKPGG--FDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVI 248

Query: 1389 FIFAVVAVQLFKGK------FFHCTDESKEFEKDC----RGKYLLYEKNEVKARDREWKK 1438
             I+A++ ++LF G+      F     E++E    C     G+     + E + R      
Sbjct: 249  IIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNG 308

Query: 1439 YEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVF 1498
               ++DN  +A+LT+F   T EGW  VL    DA         GY  E+   Y V  V+F
Sbjct: 309  GITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAM--------GY--ELPWVYFVSLVIF 358

Query: 1499 PFFFV-NIFVALIIITFQEQ-------GD--KMMEEYSLEKNERACIDFAISAKPLTRHM 1548
              FFV N+ + ++   F ++       GD  K  E+  +E++ R  +D+   A+ L    
Sbjct: 359  GSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWITQAEELDMED 418

Query: 1549 P 1549
            P
Sbjct: 419  P 419



 Score =  124 bits (312), Expect = 8e-28
 Identities = 152/713 (21%), Positives = 288/713 (40%), Gaps = 132/713 (18%)

Query: 84   DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 143
            + V+R   ++  +     + +L  +  N + +A E H      T + E  +      + +
Sbjct: 515  NRVLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKV---LLCL 571

Query: 144  FCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------FDLRTLRAV 197
            F  E  +K+  LG      +Y+ + +N  D  VV  GIL T   E        +  LR V
Sbjct: 572  FTVEMLLKLYGLG----PSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCV 627

Query: 198  RVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF 257
            R+LR  K+     SL  ++ S++ +M  +  + LLLF  I+IF+++G++ + GKF+    
Sbjct: 628  RLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFN---- 683

Query: 258  EEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITM 317
                                             ++  +   + FD    A+LTVFQ +T 
Sbjct: 684  ---------------------------------FDQTHTKRSTFDTFPQALLTVFQILTG 710

Query: 318  EGWTDLLYNSNDASGNTWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVEN 372
            E W  ++Y+   A G  +       +YFI L I G++ +LN+ L +     A        
Sbjct: 711  EDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDAGTAK 770

Query: 373  RRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTD 432
             +   K   ++ + +E  G +  + K EE     +  D E+    +              
Sbjct: 771  DKGGEK-SNEKDLPQENEGLVPGVEKEEEEGARREGADMEEEEEEE-------------- 815

Query: 433  LLNPEEAEDQLADIASVGSPFARASIKSAKL----ENSTFFHKKERR-MRFYIRRMVKTQ 487
                EE E++  +  + G    +  +   K+    E S FF   +   +R     ++   
Sbjct: 816  ----EEEEEEEEEEGAGGVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTLIHHH 871

Query: 488  AFYWTVLSLVALNTLCVAIVH-YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGT--- 543
             F   +L  + L+++ +A         + +  L Y ++ F  +F  E+ +KM   G    
Sbjct: 872  VFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLH 931

Query: 544  -RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRN 602
               +  S FN  D  +++ S+  + + +     S  + +LR LR+LR  +       L++
Sbjct: 932  RGSFCRSWFNMLD--LLVVSVSLISFGIHSSAISV-VKILRVLRVLRPLRAINRAKGLKH 988

Query: 603  LVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFN--FDEG--TPPT--------- 649
            +V  +  ++++I +++ +  L   +FA +G+QLF G+F    DE   TP           
Sbjct: 989  VVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVYP 1048

Query: 650  -------------------NFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMV- 689
                               NFD   +A+M +F + T E W  ++Y  I +     G +  
Sbjct: 1049 DGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYN 1108

Query: 690  ----FSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKL 738
                 S++FIV  +   + ++N+F+   +        +T   Q E+E  N +L
Sbjct: 1109 YRVEISVFFIVYIIIIAFFMMNIFVGFVI--------ITFRAQGEQEYQNCEL 1153



 Score =  113 bits (283), Expect = 2e-24
 Identities = 74/268 (27%), Positives = 134/268 (50%), Gaps = 29/268 (10%)

Query: 484  VKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGT 543
            V + AF + +  L+ LNT+ +A+ HY Q    +  +     +F GLF  EM +K+     
Sbjct: 1187 VNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKP 1246

Query: 544  RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFG----------ISVLRALRLLRIFKV 593
            + YF  ++N FD  +++GSI ++    +  G   G          I+  R  R++R+ K+
Sbjct: 1247 KHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKL 1306

Query: 594  TKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTP---PTN 650
                  +R L+ + + S +++  +  L+ +   ++A++GMQ+F G+    +GT      N
Sbjct: 1307 LSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMF-GKVALQDGTQINRNNN 1365

Query: 651  FDTFPAAIMTVFQILTGEDWNEVMYDGI-------KSQGG----VQGGMVFSI-YFIVLT 698
            F TFP A++ +F+  TGE W E+M   +       +S  G       G  F+I YFI   
Sbjct: 1366 FQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFF 1425

Query: 699  LFGNYTLLNVFLAIAVDNLANAQELTKD 726
            +   + ++N+F+A+ +DN      LT+D
Sbjct: 1426 MLCAFLIINLFVAVIMDNF---DYLTRD 1450



 Score =  106 bits (264), Expect = 3e-22
 Identities = 93/331 (28%), Positives = 159/331 (48%), Gaps = 33/331 (9%)

Query: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
            + F  S+ N +RK    +     F  +IL  II + + LA E   P    +  +  L   
Sbjct: 850  AFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAED--PIRAHSFRNHILGYF 907

Query: 137  EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
            +  F  IF  E  +K+   G   H+GS+ R+ +N++D +VV   +++  G        ++
Sbjct: 908  DYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLIS-FGIHSSAISVVK 966

Query: 193  TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      +FA IG++ + GKF
Sbjct: 967  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1026

Query: 253  HTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQP-----YWEGPNNGITQFDNILFA 307
            + TC +E        +P  C  +      P+G   +P      W    N    FDN+L A
Sbjct: 1027 Y-TCTDEAK-----HTPQEC--KGSFLVYPDGDVSRPLVRERLWV---NSDFNFDNVLSA 1075

Query: 308  VLTVFQCITMEGWTDLLYNSNDA----SGNTWNW-----LYFIPLIIIGSFFMLNLVLGV 358
            ++ +F   T EGW  LLY + DA     G  +N+     ++FI  III +FFM+N+ +G 
Sbjct: 1076 MMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGF 1135

Query: 359  LSGEFAKERERVENRRAFLKLRRQQQIEREL 389
            +   F  + E+ E +   L   ++Q +E  L
Sbjct: 1136 VIITFRAQGEQ-EYQNCELDKNQRQCVEYAL 1165



 Score =  100 bits (250), Expect = 1e-20
 Identities = 78/301 (25%), Positives = 148/301 (49%), Gaps = 22/301 (7%)

Query: 1515 QEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMA 1574
            + QGD+  EE +L    R C++  +  + + R + +  +  + R  + V S    + ++ 
Sbjct: 480  ETQGDEDEEEGALASCTR-CLNKIMKTR-VCRRLRRANRVLRARCRRAVKSNACYWAVLL 537

Query: 1575 MIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFD 1634
            ++ LNT+ +  + +G  V         N V   LF++E +LK+   G   Y    +N FD
Sbjct: 538  LVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFD 597

Query: 1635 FVTVLGSITDILVTEFGN-NFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALP 1693
               V G I +  + E G    + +S LR  R  R+ K+ R   ++  L+ + + S K++ 
Sbjct: 598  CFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIA 657

Query: 1694 YVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSA 1753
             + LL+ +   I++++GMQ+FG         + D+     T+ + F TF QAL+ +F+  
Sbjct: 658  SLLLLLFLFIIIFSLLGMQLFGG------KFNFDQTH---TKRSTFDTFPQALLTVFQIL 708

Query: 1754 TGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMD 1812
            TGE W+ +M   +         G+L           YF+  +F+C ++++LN+F+A+ +D
Sbjct: 709  TGEDWNVVMYDGIMAYGGPFFPGML--------VCIYFI-ILFICGNYILLNVFLAIAVD 759

Query: 1813 N 1813
            N
Sbjct: 760  N 760



 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 98/424 (23%), Positives = 177/424 (41%), Gaps = 100/424 (23%)

Query: 493 VLSLVALNTLCVAI-VHYNQPEWLSDF----LYYAEFIFLGLFMSEMFIKM--YGLGTRP 545
           +L L+ +   CVA+ V+   PE  S+     L   E++FL +F  E  +K+  YGL   P
Sbjct: 96  ILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHP 155

Query: 546 --YFHSSFNCFDCGVIIGSIFEVIWAVI------------KPGTSFGISVLRALRLLRIF 591
             Y  + +N  D  +++  +F V+                KPG  F +  LRA R+LR  
Sbjct: 156 SAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPG-GFDVKALRAFRVLRPL 214

Query: 592 KVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLF-----------GGQF 640
           ++     SL  ++ S++ ++  ++ +  L+   I+++A++G++LF           G   
Sbjct: 215 RLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDM 274

Query: 641 NFDEGTPP----------------------------TNFDTFPAAIMTVFQILTGEDWNE 672
             +E   P                            TNFD F  A++TVFQ +T E W +
Sbjct: 275 EAEEDPSPCASSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTD 334

Query: 673 VMYDGIKSQGGVQGGMVFS---IYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTK---- 725
           V+Y        +Q  M +    +YF+ L +FG++ +LN+ L +     +  +E  K    
Sbjct: 335 VLY-------WMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGD 387

Query: 726 -DEQEEEEAANQKLA-----LQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWEQR- 778
             +Q E++   + L      + +A+E+    P +  N+    +E +   +P  +    R 
Sbjct: 388 FQKQREKQQMEEDLRGYLDWITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRR 447

Query: 779 -------TSEMRKQNLLASREAL-----------YNEMDPDERWKAAYTRHLRPDMKTHL 820
                  +   R  +  +S  +L             + D +E   A+ TR L   MKT +
Sbjct: 448 RGRLRWFSHSTRSTHSTSSHASLPASDTGSMTETQGDEDEEEGALASCTRCLNKIMKTRV 507

Query: 821 DRPL 824
            R L
Sbjct: 508 CRRL 511



 Score = 86.3 bits (212), Expect = 3e-16
 Identities = 69/280 (24%), Positives = 126/280 (45%), Gaps = 40/280 (14%)

Query: 1233 LRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEM 1292
            LR  C   +        +L+++ ++++ +A+E   QP      +  Y + V   +FT EM
Sbjct: 518  LRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQP-VWLTQIQEYANKVLLCLFTVEM 576

Query: 1293 VIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLR 1352
            ++K+  LG      AY    +N  D  VV G ++          + +  I  LR +R+LR
Sbjct: 577  LLKLYGLG----PSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLG-ISVLRCVRLLR 631

Query: 1353 PLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKE 1412
              K  +    L  +   ++NS+K++ ++L++  LF+ IF+++ +QLF GKF      +K 
Sbjct: 632  IFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKR 691

Query: 1413 FEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDA 1472
                                          +D    ALLT+F + TGE W  V+    D 
Sbjct: 692  ST----------------------------FDTFPQALLTVFQILTGEDWNVVM---YDG 720

Query: 1473 TFENQGP-SPGYRMEMSIFYVVYFVVFPFFFVNIFVALII 1511
                 GP  PG  M + I++++ F+   +  +N+F+A+ +
Sbjct: 721  IMAYGGPFFPG--MLVCIYFIILFICGNYILLNVFLAIAV 758



 Score = 82.0 bits (201), Expect = 6e-15
 Identities = 72/297 (24%), Positives = 130/297 (43%), Gaps = 63/297 (21%)

Query: 1567 PFEYTIMAMIALNTIVLMMKFY----GASVAYENALRVFNIVFTSLFSLECVLKVMAFGI 1622
            PF+  I+  I  N + L +        ++ A  N  +V   VF  +F++E VLK++A+G+
Sbjct: 93   PFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQV-EYVFLVIFTVETVLKIVAYGL 151

Query: 1623 L----NYFRDAWNIFDFVTVLGSITDILVTEFGNN------------FINLSFLRLFRAA 1666
            +     Y R+ WN+ DF+ V+  +  +L+ +                  ++  LR FR  
Sbjct: 152  VLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVL 211

Query: 1667 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGN--------IG 1718
            R ++L+    ++ I+L + +++   L ++ LL+  +  IYAIIG+++F          +G
Sbjct: 212  RPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLG 271

Query: 1719 IDVEDEDSDED----------EFQITE-----------HNNFRTFFQALMLLFRSATGEA 1757
             D+E E+                  TE             NF  FF A++ +F+  T E 
Sbjct: 272  SDMEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEG 331

Query: 1758 WHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
            W +++               +    G E  + YFVS +   SF +LNL + V+   F
Sbjct: 332  WTDVLY-------------WMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 375



 Score = 73.2 bits (178), Expect = 3e-12
 Identities = 66/296 (22%), Positives = 117/296 (39%), Gaps = 75/296 (25%)

Query: 100  FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
            FEY++   I+ N + LA++ +   +   P +  +D     F G+F  E  +KIIA    F
Sbjct: 1192 FEYLMFLLILLNTVALAMQHY---EQTAPFNYAMDILNMVFTGLFTIEMVLKIIA----F 1244

Query: 160  HKGSYLRNGWNVMDFVVVLTGILATVGTEFD----------------LRTLRAVRVLRPL 203
                Y  + WN  D ++V+  I+    TE +                +   R  RV+R +
Sbjct: 1245 KPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLV 1304

Query: 204  KLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDD 263
            KL+S    ++ +L + +K+   L  + LL+     I+A+IG++     F     ++GT  
Sbjct: 1305 KLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQM----FGKVALQDGTQ- 1359

Query: 264  IQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDL 323
                                           NN    F     AVL +F+C T E W ++
Sbjct: 1360 ----------------------------INRNNNFQTFPQ---AVLLLFRCATGEAWQEI 1388

Query: 324  LYNSNDAS----------------GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 363
            +  S   +                G+ +   YFI   ++ +F ++NL + V+   F
Sbjct: 1389 MLASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDNF 1444


>gi|193788724 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 2 [Homo sapiens]
          Length = 2186

 Score =  759 bits (1961), Expect = 0.0
 Identities = 407/917 (44%), Positives = 567/917 (61%), Gaps = 104/917 (11%)

Query: 1146 IVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEE 1205
            +V  P+  ++   K   K      + PPA    +N   +Q N+N +  P P  E   +E+
Sbjct: 790  LVEKPAVGESKEEKIELKSITADGESPPATK--INMDDLQPNENEDKSPYPNPETTGEED 847

Query: 1206 EEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLCHYILNLRYFEMCIL 1251
            EE+     GP+P              MP  S+ FI S+ N  R  CH I+N   F   IL
Sbjct: 848  EEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLIL 907

Query: 1252 MVIAMSSIALAAEDPVQPNAPRNNVLRYFD--------------------YVFTGVFTFE 1291
              I +SSI+LAAEDPVQ  + RN++L YFD                    YVFT +FT E
Sbjct: 908  FFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLE 967

Query: 1292 MVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVL 1351
            +++KM   G  LH+G++ R+ +NILD +VVS +L++F    ++    IN +K LRVLRVL
Sbjct: 968  IILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA----INVVKILRVLRVL 1023

Query: 1352 RPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESK 1411
            RPL+ I R   LK V  CV  +++ + NI+IV  L  F+FA + VQLFKGK + C+D SK
Sbjct: 1024 RPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSK 1083

Query: 1412 EFEKDCRGKYLLYEKNEVK---ARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKH 1468
            + E +C+G Y+ Y+  EV     + R W+  +F +DNVL A++ LFTVST EGWP++L  
Sbjct: 1084 QTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYR 1143

Query: 1469 SVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLE 1528
            S+D+  E++GP   YR+E+SIF+++Y ++  FF +NIFV  +I+TFQEQG++  +   L+
Sbjct: 1144 SIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELD 1203

Query: 1529 KNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFY 1588
            KN+R C+++A+ A+PL R++P+N+   QY++W  V S  FEY +  +I LNTI L M+ Y
Sbjct: 1204 KNQRQCVEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHY 1261

Query: 1589 GASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVT 1648
            G S  ++ A+ + N++FT LF++E +LK++AF    YF D WN+FDF+ V+GSI D++++
Sbjct: 1262 GQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILS 1321

Query: 1649 EFGNNF-------------------------------------------INLSFLRLFRA 1665
            E  + F                                           I+++F RLFR 
Sbjct: 1322 ETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1381

Query: 1666 ARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDED 1725
             RL+KLL +G  IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQVFG I ++     
Sbjct: 1382 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALN----- 1436

Query: 1726 SDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPC-----DKNSGILTR 1780
               D  +I  +NNF+TF QA++LLFR ATGEAW +IML+C+ GK C       NS     
Sbjct: 1437 ---DTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGET 1493

Query: 1781 ECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYD 1840
             CG+ FA FYF+SF  LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDE+ R+WAEYD
Sbjct: 1494 PCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYD 1553

Query: 1841 PAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMAL 1900
            P A GRI + D+ +LLR I PPLG GK CPHRVACKRL+ M++P+  D TV FN+TL AL
Sbjct: 1554 PEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFAL 1613

Query: 1901 IRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAM 1960
            +RTAL IK      + +Q + ELR  +  IW   S K LD +V P    ++TVGK YA  
Sbjct: 1614 VRTALRIKTE---GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATF 1670

Query: 1961 MIMEYYRQSKAKKLQAM 1977
            +I EY+R+ K +K Q +
Sbjct: 1671 LIQEYFRKFKKRKEQGL 1687



 Score =  671 bits (1730), Expect = 0.0
 Identities = 383/827 (46%), Positives = 507/827 (61%), Gaps = 64/827 (7%)

Query: 2   ARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQG-----------GQPGAQRMYKQ 50
           + +G   PA +    + AAAG+        GA  S Q            G  G   +   
Sbjct: 18  SNYGSPRPA-HANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTV 76

Query: 51  SMAQRARTMALYNPIPVRQNCLTVNR---SLFLFSEDNVVRKYAKKITEWPPFEYMILAT 107
           S  QR R    Y   P +Q   T  R   +L   +  N +R+    I EW PFE +IL T
Sbjct: 77  SSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLT 133

Query: 108 IIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRN 167
           I ANC+ LA+    P+DD    +  L+  E  F+ IF  EA +K+IA G  FH  +YLRN
Sbjct: 134 IFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRN 193

Query: 168 GWNVMDFVVVLTGILATV----------------GTEFDLRTLRAVRVLRPLKLVSGIPS 211
           GWN++DF++V+ G+ + +                G  FD++ LRA RVLRPL+LVSG+PS
Sbjct: 194 GWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPS 253

Query: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF-EEGTDDIQGES-P 269
           LQVVL SI+KAM+PLL I LL+ F I+I+AIIGLE +MGK H TC+ +EG  D+  E  P
Sbjct: 254 LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 270 APCGTEEP-ARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSN 328
           +PC  E    R C NGT C+P W+GP +GIT FDN  FA+LTVFQCITMEGWTD+LY  N
Sbjct: 314 SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 329 DASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 388
           DA G  W W+YF+ LIIIGSFF+LNLVLGVLSGEF+KERE+ + R  F KLR +QQ+E +
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433

Query: 389 LNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIAS 448
           L GY++WI++AE++    ++   ++  P     R  ++  S+T+ +N E       +  +
Sbjct: 434 LKGYLDWITQAEDIDPENEDEGMDEEKP-----RNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 449 VGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH 508
            G   AR + + +K + S ++ +  R  R   R  VK+  FYW V+ LV LNTL +A  H
Sbjct: 489 CG---ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEH 545

Query: 509 YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIW 568
           YNQP WL++    A    L LF +EM +KMY LG + YF S FN FDC V+ G I E I 
Sbjct: 546 YNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETIL 605

Query: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
              K  +  GISVLR +RLLRIFK+T+YW SL NLV SLLNS++SI SLL LLFLFI++F
Sbjct: 606 VETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIF 665

Query: 629 ALLGMQLFGGQFNFDE-GTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQ-G 686
           +LLGMQLFGG+FNFDE  T  + FD FP +++TVFQILTGEDWN VMYDGI + GG    
Sbjct: 666 SLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 687 GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEV 746
           GM+  IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EEEE   +K         
Sbjct: 726 GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERK--------- 776

Query: 747 AEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREA 793
                   A  +   K+Q+  +KPA  V E +  ++  +++ A  E+
Sbjct: 777 ------KLARTASPEKKQELVEKPA--VGESKEEKIELKSITADGES 815



 Score =  202 bits (513), Expect = 4e-51
 Identities = 176/705 (24%), Positives = 317/705 (44%), Gaps = 120/705 (17%)

Query: 1200 EEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSI 1259
            + K+++    + +       P  ++  L+  NP+RR C  I+  + FE+ IL+ I  + +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1260 ALAAEDPV---QPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNIL 1316
            ALA   P      NA  +N+ R  +Y+F  +FT E  +K+I  GL+ H  AY R+ WN+L
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV-EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198

Query: 1317 DFIVVSGALVAFAFTGNSKGKDINT---------IKSLRVLRVLRPLKTIKRLPKLKAVF 1367
            DFI+V   L +      +K    N          +K+LR  RVLRPL+ +  +P L+ V 
Sbjct: 199  DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258

Query: 1368 DCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC---------- 1417
            + ++ ++  + +I ++ +  + I+A++ ++LF GK  H T  ++E   D           
Sbjct: 259  NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK-MHKTCYNQEGIADVPAEDDPSPCA 317

Query: 1418 --RGKYLLYEKNEVKARDREWKKYEF-HYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
               G     +   V     +  K+   ++DN  +A+LT+F   T EGW  VL    DA  
Sbjct: 318  LETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAV- 376

Query: 1475 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KMMEEY 1525
                     R    I++V   ++  FF +N+ + ++   F ++       GD  K+ E+ 
Sbjct: 377  --------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428

Query: 1526 SLEKNERACIDFAISA---------------KPLTRHMP--------------------- 1549
             LE++ +  +D+   A               KP    MP                     
Sbjct: 429  QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 1550 ----------QNKQSFQYRMWQ---------FVVSPPFEYTIMAMIALNTIVLMMKFYGA 1590
                      ++K S  +R W           V S  F + ++ ++ LNT+ +  + Y  
Sbjct: 489  CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548

Query: 1591 SVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITD-ILVTE 1649
                       N    +LF+ E +LK+ + G+  YF   +N FD   V G I + ILV  
Sbjct: 549  PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 1650 FGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAII 1709
               + + +S LR  R  R+ K+ R   ++  L+ + + S +++  + LL+ +   I++++
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 1710 GMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGK 1769
            GMQ+FG           + DE Q T  + F  F Q+L+ +F+  TGE W+++M   +   
Sbjct: 669  GMQLFGG--------KFNFDEMQ-TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAY 719

Query: 1770 PCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
                  G+L           YF+  +F+C ++++LN+F+A+ +DN
Sbjct: 720  GGPSFPGML--------VCIYFI-ILFICGNYILLNVFLAIAVDN 755



 Score =  137 bits (344), Expect = 2e-31
 Identities = 181/804 (22%), Positives = 330/804 (41%), Gaps = 179/804 (22%)

Query: 33   AGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAK 92
            AGG  +G   GA+  ++ S ++ +R    +N    R+ C    +S       NV      
Sbjct: 480  AGGDIEGENCGARLAHRISKSKFSRYWRRWNRF-CRRKCRAAVKS-------NV------ 525

Query: 93   KITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKI 152
                   F ++++  +  N + +A E +   +    ++E  D      + +F  E  +K+
Sbjct: 526  -------FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKM 575

Query: 153  IALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------FDLRTLRAVRVLRPLKLV 206
             +LG      +Y  + +N  D  VV  GIL T+  E        +  LR VR+LR  K+ 
Sbjct: 576  YSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKIT 631

Query: 207  SGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQG 266
                SL  ++ S++ ++  +  + LLLF  I+IF+++G++ + GKF+        D++Q 
Sbjct: 632  RYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF-------DEMQT 684

Query: 267  ESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYN 326
                                            + FDN   ++LTVFQ +T E W  ++Y+
Sbjct: 685  RR------------------------------STFDNFPQSLLTVFQILTGEDWNSVMYD 714

Query: 327  SNDASGNT-----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERE 368
               A G          +YFI L I G++ +LN+ L +     A             +E+E
Sbjct: 715  GIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKE 774

Query: 369  RVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIK- 427
            R +  R     ++Q+ +E+   G     SK E++ L     DGE   P    +    ++ 
Sbjct: 775  RKKLARTASPEKKQELVEKPAVGE----SKEEKIELKSITADGES--PPATKINMDDLQP 828

Query: 428  ---KSKTDLLNPEEA--EDQLADIASVGS---PFARASIKSAKL---ENSTFF-HKKERR 475
               + K+   NPE    ED+      VG    P +   +K   +   E S FF      R
Sbjct: 829  NENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNR 888

Query: 476  MRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ-PEWLSDFLYYAEFIFLGLFMSEM 534
             R    R+V    F   +L  + L+++ +A     Q   + +  L+Y + +F  +F  E+
Sbjct: 889  FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEI 948

Query: 535  FIKMYGLGTRPYFHSSFNCFDC-------------GVIIGSIFEVIWAVIKPGT--SFGI 579
             +K+  LG   Y  +S    +              G    + F ++  ++   +  SFGI
Sbjct: 949  ALKI--LGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGI 1006

Query: 580  S--------VLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALL 631
                     +LR LR+LR  +       L+++V  +  ++++I +++ +  L   +FA +
Sbjct: 1007 QSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1066

Query: 632  GMQLFGGQ-FNFDEGTPPT-------------------------------NFDTFPAAIM 659
            G+QLF G+ +   + +  T                               +FD   AA+M
Sbjct: 1067 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1126

Query: 660  TVFQILTGEDWNEVMYDGIKSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAV 714
             +F + T E W E++Y  I S    +G +       SI+FI+  +   + ++N+F+   +
Sbjct: 1127 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1186

Query: 715  DNLANAQELTKDEQEEEEAANQKL 738
                    +T  EQ E+E  N +L
Sbjct: 1187 --------VTFQEQGEQEYKNCEL 1202



 Score =  107 bits (266), Expect = 2e-22
 Identities = 97/349 (27%), Positives = 164/349 (46%), Gaps = 49/349 (14%)

Query: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALE---QHLPDDDKTPMS--- 130
            + F+FS +N  R    +I     F  +IL  I+ + I LA E   QH    +        
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDI 938

Query: 131  ------------ERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVL 178
                        + L + +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV 
Sbjct: 939  VFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVS 998

Query: 179  TGILATVGTEFD----LRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLF 234
              ++ + G +      ++ LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++  
Sbjct: 999  VSLI-SFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1057

Query: 235  FAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPY---- 290
                +FA IG++ + GK +T        D   ++ A C  +    T  +G    P     
Sbjct: 1058 LLQFMFACIGVQLFKGKLYT------CSDSSKQTEAEC--KGNYITYKDGEVDHPIIQPR 1109

Query: 291  -WEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDA----SGNTWNW-----LYF 340
             WE   N    FDN+L A++ +F   T EGW +LLY S D+     G  +N+     ++F
Sbjct: 1110 SWE---NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFF 1166

Query: 341  IPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIEREL 389
            I  III +FFM+N+ +G +   F ++ E+ E +   L   ++Q +E  L
Sbjct: 1167 IIYIIIIAFFMMNIFVGFVIVTFQEQGEQ-EYKNCELDKNQRQCVEYAL 1214



 Score =  103 bits (256), Expect = 3e-21
 Identities = 80/322 (24%), Positives = 142/322 (44%), Gaps = 70/322 (21%)

Query: 472  KERRMRFYIRR---------MVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 522
            K R +R YI +         +V +  F + +  L+ LNT+C+A+ HY Q       +   
Sbjct: 1215 KARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNIL 1274

Query: 523  EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVI-----------W--- 568
              +F GLF  EM +K+     + YF   +N FD  ++IGSI +VI           W   
Sbjct: 1275 NMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTF 1334

Query: 569  -AVIKPGTSFGISV---------------------------LRALRLLRIFKVTKYWASL 600
             A+I  G+   I++                            R  R++R+ K+      +
Sbjct: 1335 DALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGI 1394

Query: 601  RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG--GQFNFDEGTPPTNFDTFPAAI 658
            R L+ + + S +++  +  L+ +   ++A++GMQ+FG     +  E     NF TFP A+
Sbjct: 1395 RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAV 1454

Query: 659  MTVFQILTGEDWNEVMY-------------DGIKSQGGVQGGMVFSI-YFIVLTLFGNYT 704
            + +F+  TGE W ++M                  ++G    G  F++ YFI   +   + 
Sbjct: 1455 LLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFL 1514

Query: 705  LLNVFLAIAVDNLANAQELTKD 726
            ++N+F+A+ +DN      LT+D
Sbjct: 1515 IINLFVAVIMDNF---DYLTRD 1533



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 79/311 (25%), Positives = 143/311 (45%), Gaps = 41/311 (13%)

Query: 1234 RRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMV 1293
            RR C   +    F   ++ ++ ++++ +A+E   QPN     V    +     +FT EM+
Sbjct: 514  RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW-LTEVQDTANKALLALFTAEML 572

Query: 1294 IKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRP 1353
            +KM  LGL     AYF  L+N  D  VV G ++            +  I  LR +R+LR 
Sbjct: 573  LKMYSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLG-ISVLRCVRLLRI 627

Query: 1354 LKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEF 1413
             K  +    L  +   ++NS++++ ++L++  LF+ IF+++ +QLF GKF          
Sbjct: 628  FKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF---------- 677

Query: 1414 EKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDAT 1473
                         +E++ R          +DN   +LLT+F + TGE W  V+    D  
Sbjct: 678  -----------NFDEMQTRRST-------FDNFPQSLLTVFQILTGEDWNSVM---YDGI 716

Query: 1474 FENQGPS-PGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNER 1532
                GPS PG  M + I++++ F+   +  +N+F+A+ +    +  + +      E+ E+
Sbjct: 717  MAYGGPSFPG--MLVCIYFIILFICGNYILLNVFLAIAVDNLAD-AESLTSAQKEEEEEK 773

Query: 1533 ACIDFAISAKP 1543
                 A +A P
Sbjct: 774  ERKKLARTASP 784



 Score = 82.0 bits (201), Expect = 6e-15
 Identities = 73/297 (24%), Positives = 130/297 (43%), Gaps = 62/297 (20%)

Query: 1567 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1623
            PFE  I+  I  N + L +        S A  + L     +F  +F++E  LKV+A+G+L
Sbjct: 125  PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1624 ----NYFRDAWNIFDFVTVLGSITDILVTEF----GNNFI-------NLSFLRLFRAARL 1668
                 Y R+ WN+ DF+ V+  +   ++ +     G N +       ++  LR FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1669 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF---------GNIGI 1719
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F            GI
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1720 -DVEDEDSDEDEFQITEH---------------------NNFRTFFQALMLLFRSATGEA 1757
             DV  ED        T H                      NF  F  A++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1758 WHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
            W +++               +    G ++ + YFV+ I + SF +LNL + V+   F
Sbjct: 365  WTDVLY-------------WVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408



 Score = 57.4 bits (137), Expect = 2e-07
 Identities = 72/330 (21%), Positives = 122/330 (36%), Gaps = 109/330 (33%)

Query: 100  FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
            FEY++   I+ N I LA++ +            ++     F G+F  E  +K+IA    F
Sbjct: 1241 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1293

Query: 160  HKGSYLRNGWNVMDFVVVLTGILATVGTE-----------FD------------------ 190
                Y  + WNV DF++V+  I+  + +E           FD                  
Sbjct: 1294 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNP 1353

Query: 191  -------------------LRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGL 231
                               +   R  RV+R +KL+S    ++ +L + +K+   L  + L
Sbjct: 1354 AEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1413

Query: 232  LLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYW 291
            L+     I+A+IG++ + GK                  A   T E  R            
Sbjct: 1414 LIVMLFFIYAVIGMQVF-GKI-----------------ALNDTTEINR------------ 1443

Query: 292  EGPNNGITQFDNILFAVLTVFQCITMEGWTDLLY---------------NSNDAS---GN 333
               NN    F     AVL +F+C T E W D++                NS +     G+
Sbjct: 1444 ---NNNFQTFPQ---AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGS 1497

Query: 334  TWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 363
            ++   YFI   ++ +F ++NL + V+   F
Sbjct: 1498 SFAVFYFISFYMLCAFLIINLFVAVIMDNF 1527


>gi|193788720 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 1 [Homo sapiens]
          Length = 2221

 Score =  759 bits (1961), Expect = 0.0
 Identities = 407/917 (44%), Positives = 567/917 (61%), Gaps = 104/917 (11%)

Query: 1146 IVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEE 1205
            +V  P+  ++   K   K      + PPA    +N   +Q N+N +  P P  E   +E+
Sbjct: 790  LVEKPAVGESKEEKIELKSITADGESPPATK--INMDDLQPNENEDKSPYPNPETTGEED 847

Query: 1206 EEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLCHYILNLRYFEMCIL 1251
            EE+     GP+P              MP  S+ FI S+ N  R  CH I+N   F   IL
Sbjct: 848  EEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLIL 907

Query: 1252 MVIAMSSIALAAEDPVQPNAPRNNVLRYFD--------------------YVFTGVFTFE 1291
              I +SSI+LAAEDPVQ  + RN++L YFD                    YVFT +FT E
Sbjct: 908  FFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLE 967

Query: 1292 MVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVL 1351
            +++KM   G  LH+G++ R+ +NILD +VVS +L++F    ++    IN +K LRVLRVL
Sbjct: 968  IILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA----INVVKILRVLRVL 1023

Query: 1352 RPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESK 1411
            RPL+ I R   LK V  CV  +++ + NI+IV  L  F+FA + VQLFKGK + C+D SK
Sbjct: 1024 RPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSK 1083

Query: 1412 EFEKDCRGKYLLYEKNEVK---ARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKH 1468
            + E +C+G Y+ Y+  EV     + R W+  +F +DNVL A++ LFTVST EGWP++L  
Sbjct: 1084 QTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYR 1143

Query: 1469 SVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLE 1528
            S+D+  E++GP   YR+E+SIF+++Y ++  FF +NIFV  +I+TFQEQG++  +   L+
Sbjct: 1144 SIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELD 1203

Query: 1529 KNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFY 1588
            KN+R C+++A+ A+PL R++P+N+   QY++W  V S  FEY +  +I LNTI L M+ Y
Sbjct: 1204 KNQRQCVEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHY 1261

Query: 1589 GASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVT 1648
            G S  ++ A+ + N++FT LF++E +LK++AF    YF D WN+FDF+ V+GSI D++++
Sbjct: 1262 GQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILS 1321

Query: 1649 EFGNNF-------------------------------------------INLSFLRLFRA 1665
            E  + F                                           I+++F RLFR 
Sbjct: 1322 ETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1381

Query: 1666 ARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDED 1725
             RL+KLL +G  IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQVFG I ++     
Sbjct: 1382 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALN----- 1436

Query: 1726 SDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPC-----DKNSGILTR 1780
               D  +I  +NNF+TF QA++LLFR ATGEAW +IML+C+ GK C       NS     
Sbjct: 1437 ---DTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGET 1493

Query: 1781 ECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYD 1840
             CG+ FA FYF+SF  LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDE+ R+WAEYD
Sbjct: 1494 PCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYD 1553

Query: 1841 PAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMAL 1900
            P A GRI + D+ +LLR I PPLG GK CPHRVACKRL+ M++P+  D TV FN+TL AL
Sbjct: 1554 PEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFAL 1613

Query: 1901 IRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAM 1960
            +RTAL IK      + +Q + ELR  +  IW   S K LD +V P    ++TVGK YA  
Sbjct: 1614 VRTALRIKTE---GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATF 1670

Query: 1961 MIMEYYRQSKAKKLQAM 1977
            +I EY+R+ K +K Q +
Sbjct: 1671 LIQEYFRKFKKRKEQGL 1687



 Score =  671 bits (1730), Expect = 0.0
 Identities = 383/827 (46%), Positives = 507/827 (61%), Gaps = 64/827 (7%)

Query: 2   ARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQG-----------GQPGAQRMYKQ 50
           + +G   PA +    + AAAG+        GA  S Q            G  G   +   
Sbjct: 18  SNYGSPRPA-HANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTV 76

Query: 51  SMAQRARTMALYNPIPVRQNCLTVNR---SLFLFSEDNVVRKYAKKITEWPPFEYMILAT 107
           S  QR R    Y   P +Q   T  R   +L   +  N +R+    I EW PFE +IL T
Sbjct: 77  SSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLT 133

Query: 108 IIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRN 167
           I ANC+ LA+    P+DD    +  L+  E  F+ IF  EA +K+IA G  FH  +YLRN
Sbjct: 134 IFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRN 193

Query: 168 GWNVMDFVVVLTGILATV----------------GTEFDLRTLRAVRVLRPLKLVSGIPS 211
           GWN++DF++V+ G+ + +                G  FD++ LRA RVLRPL+LVSG+PS
Sbjct: 194 GWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPS 253

Query: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF-EEGTDDIQGES-P 269
           LQVVL SI+KAM+PLL I LL+ F I+I+AIIGLE +MGK H TC+ +EG  D+  E  P
Sbjct: 254 LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 270 APCGTEEP-ARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSN 328
           +PC  E    R C NGT C+P W+GP +GIT FDN  FA+LTVFQCITMEGWTD+LY  N
Sbjct: 314 SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 329 DASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 388
           DA G  W W+YF+ LIIIGSFF+LNLVLGVLSGEF+KERE+ + R  F KLR +QQ+E +
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433

Query: 389 LNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIAS 448
           L GY++WI++AE++    ++   ++  P     R  ++  S+T+ +N E       +  +
Sbjct: 434 LKGYLDWITQAEDIDPENEDEGMDEEKP-----RNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 449 VGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH 508
            G   AR + + +K + S ++ +  R  R   R  VK+  FYW V+ LV LNTL +A  H
Sbjct: 489 CG---ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEH 545

Query: 509 YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIW 568
           YNQP WL++    A    L LF +EM +KMY LG + YF S FN FDC V+ G I E I 
Sbjct: 546 YNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETIL 605

Query: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
              K  +  GISVLR +RLLRIFK+T+YW SL NLV SLLNS++SI SLL LLFLFI++F
Sbjct: 606 VETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIF 665

Query: 629 ALLGMQLFGGQFNFDE-GTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQ-G 686
           +LLGMQLFGG+FNFDE  T  + FD FP +++TVFQILTGEDWN VMYDGI + GG    
Sbjct: 666 SLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 687 GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEV 746
           GM+  IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EEEE   +K         
Sbjct: 726 GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERK--------- 776

Query: 747 AEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREA 793
                   A  +   K+Q+  +KPA  V E +  ++  +++ A  E+
Sbjct: 777 ------KLARTASPEKKQELVEKPA--VGESKEEKIELKSITADGES 815



 Score =  202 bits (513), Expect = 4e-51
 Identities = 176/705 (24%), Positives = 317/705 (44%), Gaps = 120/705 (17%)

Query: 1200 EEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSI 1259
            + K+++    + +       P  ++  L+  NP+RR C  I+  + FE+ IL+ I  + +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1260 ALAAEDPV---QPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNIL 1316
            ALA   P      NA  +N+ R  +Y+F  +FT E  +K+I  GL+ H  AY R+ WN+L
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV-EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198

Query: 1317 DFIVVSGALVAFAFTGNSKGKDINT---------IKSLRVLRVLRPLKTIKRLPKLKAVF 1367
            DFI+V   L +      +K    N          +K+LR  RVLRPL+ +  +P L+ V 
Sbjct: 199  DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258

Query: 1368 DCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC---------- 1417
            + ++ ++  + +I ++ +  + I+A++ ++LF GK  H T  ++E   D           
Sbjct: 259  NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK-MHKTCYNQEGIADVPAEDDPSPCA 317

Query: 1418 --RGKYLLYEKNEVKARDREWKKYEF-HYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
               G     +   V     +  K+   ++DN  +A+LT+F   T EGW  VL    DA  
Sbjct: 318  LETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAV- 376

Query: 1475 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KMMEEY 1525
                     R    I++V   ++  FF +N+ + ++   F ++       GD  K+ E+ 
Sbjct: 377  --------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428

Query: 1526 SLEKNERACIDFAISA---------------KPLTRHMP--------------------- 1549
             LE++ +  +D+   A               KP    MP                     
Sbjct: 429  QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488

Query: 1550 ----------QNKQSFQYRMWQ---------FVVSPPFEYTIMAMIALNTIVLMMKFYGA 1590
                      ++K S  +R W           V S  F + ++ ++ LNT+ +  + Y  
Sbjct: 489  CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548

Query: 1591 SVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITD-ILVTE 1649
                       N    +LF+ E +LK+ + G+  YF   +N FD   V G I + ILV  
Sbjct: 549  PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 1650 FGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAII 1709
               + + +S LR  R  R+ K+ R   ++  L+ + + S +++  + LL+ +   I++++
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 1710 GMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGK 1769
            GMQ+FG           + DE Q T  + F  F Q+L+ +F+  TGE W+++M   +   
Sbjct: 669  GMQLFGG--------KFNFDEMQ-TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAY 719

Query: 1770 PCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
                  G+L           YF+  +F+C ++++LN+F+A+ +DN
Sbjct: 720  GGPSFPGML--------VCIYFI-ILFICGNYILLNVFLAIAVDN 755



 Score =  137 bits (344), Expect = 2e-31
 Identities = 181/804 (22%), Positives = 330/804 (41%), Gaps = 179/804 (22%)

Query: 33   AGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAK 92
            AGG  +G   GA+  ++ S ++ +R    +N    R+ C    +S       NV      
Sbjct: 480  AGGDIEGENCGARLAHRISKSKFSRYWRRWNRF-CRRKCRAAVKS-------NV------ 525

Query: 93   KITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKI 152
                   F ++++  +  N + +A E +   +    ++E  D      + +F  E  +K+
Sbjct: 526  -------FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKM 575

Query: 153  IALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------FDLRTLRAVRVLRPLKLV 206
             +LG      +Y  + +N  D  VV  GIL T+  E        +  LR VR+LR  K+ 
Sbjct: 576  YSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKIT 631

Query: 207  SGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQG 266
                SL  ++ S++ ++  +  + LLLF  I+IF+++G++ + GKF+        D++Q 
Sbjct: 632  RYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF-------DEMQT 684

Query: 267  ESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYN 326
                                            + FDN   ++LTVFQ +T E W  ++Y+
Sbjct: 685  RR------------------------------STFDNFPQSLLTVFQILTGEDWNSVMYD 714

Query: 327  SNDASGNT-----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERE 368
               A G          +YFI L I G++ +LN+ L +     A             +E+E
Sbjct: 715  GIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKE 774

Query: 369  RVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIK- 427
            R +  R     ++Q+ +E+   G     SK E++ L     DGE   P    +    ++ 
Sbjct: 775  RKKLARTASPEKKQELVEKPAVGE----SKEEKIELKSITADGES--PPATKINMDDLQP 828

Query: 428  ---KSKTDLLNPEEA--EDQLADIASVGS---PFARASIKSAKL---ENSTFF-HKKERR 475
               + K+   NPE    ED+      VG    P +   +K   +   E S FF      R
Sbjct: 829  NENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNR 888

Query: 476  MRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ-PEWLSDFLYYAEFIFLGLFMSEM 534
             R    R+V    F   +L  + L+++ +A     Q   + +  L+Y + +F  +F  E+
Sbjct: 889  FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEI 948

Query: 535  FIKMYGLGTRPYFHSSFNCFDC-------------GVIIGSIFEVIWAVIKPGT--SFGI 579
             +K+  LG   Y  +S    +              G    + F ++  ++   +  SFGI
Sbjct: 949  ALKI--LGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGI 1006

Query: 580  S--------VLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALL 631
                     +LR LR+LR  +       L+++V  +  ++++I +++ +  L   +FA +
Sbjct: 1007 QSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1066

Query: 632  GMQLFGGQ-FNFDEGTPPT-------------------------------NFDTFPAAIM 659
            G+QLF G+ +   + +  T                               +FD   AA+M
Sbjct: 1067 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1126

Query: 660  TVFQILTGEDWNEVMYDGIKSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAV 714
             +F + T E W E++Y  I S    +G +       SI+FI+  +   + ++N+F+   +
Sbjct: 1127 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1186

Query: 715  DNLANAQELTKDEQEEEEAANQKL 738
                    +T  EQ E+E  N +L
Sbjct: 1187 --------VTFQEQGEQEYKNCEL 1202



 Score =  107 bits (266), Expect = 2e-22
 Identities = 97/349 (27%), Positives = 164/349 (46%), Gaps = 49/349 (14%)

Query: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALE---QHLPDDDKTPMS--- 130
            + F+FS +N  R    +I     F  +IL  I+ + I LA E   QH    +        
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDI 938

Query: 131  ------------ERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVL 178
                        + L + +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV 
Sbjct: 939  VFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVS 998

Query: 179  TGILATVGTEFD----LRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLF 234
              ++ + G +      ++ LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++  
Sbjct: 999  VSLI-SFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1057

Query: 235  FAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPY---- 290
                +FA IG++ + GK +T        D   ++ A C  +    T  +G    P     
Sbjct: 1058 LLQFMFACIGVQLFKGKLYT------CSDSSKQTEAEC--KGNYITYKDGEVDHPIIQPR 1109

Query: 291  -WEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDA----SGNTWNW-----LYF 340
             WE   N    FDN+L A++ +F   T EGW +LLY S D+     G  +N+     ++F
Sbjct: 1110 SWE---NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFF 1166

Query: 341  IPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIEREL 389
            I  III +FFM+N+ +G +   F ++ E+ E +   L   ++Q +E  L
Sbjct: 1167 IIYIIIIAFFMMNIFVGFVIVTFQEQGEQ-EYKNCELDKNQRQCVEYAL 1214



 Score =  103 bits (256), Expect = 3e-21
 Identities = 80/322 (24%), Positives = 142/322 (44%), Gaps = 70/322 (21%)

Query: 472  KERRMRFYIRR---------MVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 522
            K R +R YI +         +V +  F + +  L+ LNT+C+A+ HY Q       +   
Sbjct: 1215 KARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNIL 1274

Query: 523  EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVI-----------W--- 568
              +F GLF  EM +K+     + YF   +N FD  ++IGSI +VI           W   
Sbjct: 1275 NMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTF 1334

Query: 569  -AVIKPGTSFGISV---------------------------LRALRLLRIFKVTKYWASL 600
             A+I  G+   I++                            R  R++R+ K+      +
Sbjct: 1335 DALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGI 1394

Query: 601  RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG--GQFNFDEGTPPTNFDTFPAAI 658
            R L+ + + S +++  +  L+ +   ++A++GMQ+FG     +  E     NF TFP A+
Sbjct: 1395 RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAV 1454

Query: 659  MTVFQILTGEDWNEVMY-------------DGIKSQGGVQGGMVFSI-YFIVLTLFGNYT 704
            + +F+  TGE W ++M                  ++G    G  F++ YFI   +   + 
Sbjct: 1455 LLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFL 1514

Query: 705  LLNVFLAIAVDNLANAQELTKD 726
            ++N+F+A+ +DN      LT+D
Sbjct: 1515 IINLFVAVIMDNF---DYLTRD 1533



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 79/311 (25%), Positives = 143/311 (45%), Gaps = 41/311 (13%)

Query: 1234 RRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMV 1293
            RR C   +    F   ++ ++ ++++ +A+E   QPN     V    +     +FT EM+
Sbjct: 514  RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW-LTEVQDTANKALLALFTAEML 572

Query: 1294 IKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRP 1353
            +KM  LGL     AYF  L+N  D  VV G ++            +  I  LR +R+LR 
Sbjct: 573  LKMYSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLG-ISVLRCVRLLRI 627

Query: 1354 LKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEF 1413
             K  +    L  +   ++NS++++ ++L++  LF+ IF+++ +QLF GKF          
Sbjct: 628  FKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF---------- 677

Query: 1414 EKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDAT 1473
                         +E++ R          +DN   +LLT+F + TGE W  V+    D  
Sbjct: 678  -----------NFDEMQTRRST-------FDNFPQSLLTVFQILTGEDWNSVM---YDGI 716

Query: 1474 FENQGPS-PGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNER 1532
                GPS PG  M + I++++ F+   +  +N+F+A+ +    +  + +      E+ E+
Sbjct: 717  MAYGGPSFPG--MLVCIYFIILFICGNYILLNVFLAIAVDNLAD-AESLTSAQKEEEEEK 773

Query: 1533 ACIDFAISAKP 1543
                 A +A P
Sbjct: 774  ERKKLARTASP 784



 Score = 82.0 bits (201), Expect = 6e-15
 Identities = 73/297 (24%), Positives = 130/297 (43%), Gaps = 62/297 (20%)

Query: 1567 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1623
            PFE  I+  I  N + L +        S A  + L     +F  +F++E  LKV+A+G+L
Sbjct: 125  PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1624 ----NYFRDAWNIFDFVTVLGSITDILVTEF----GNNFI-------NLSFLRLFRAARL 1668
                 Y R+ WN+ DF+ V+  +   ++ +     G N +       ++  LR FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1669 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF---------GNIGI 1719
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F            GI
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1720 -DVEDEDSDEDEFQITEH---------------------NNFRTFFQALMLLFRSATGEA 1757
             DV  ED        T H                      NF  F  A++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1758 WHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
            W +++               +    G ++ + YFV+ I + SF +LNL + V+   F
Sbjct: 365  WTDVLY-------------WVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408



 Score = 57.4 bits (137), Expect = 2e-07
 Identities = 72/330 (21%), Positives = 122/330 (36%), Gaps = 109/330 (33%)

Query: 100  FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
            FEY++   I+ N I LA++ +            ++     F G+F  E  +K+IA    F
Sbjct: 1241 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1293

Query: 160  HKGSYLRNGWNVMDFVVVLTGILATVGTE-----------FD------------------ 190
                Y  + WNV DF++V+  I+  + +E           FD                  
Sbjct: 1294 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNP 1353

Query: 191  -------------------LRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGL 231
                               +   R  RV+R +KL+S    ++ +L + +K+   L  + L
Sbjct: 1354 AEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1413

Query: 232  LLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYW 291
            L+     I+A+IG++ + GK                  A   T E  R            
Sbjct: 1414 LIVMLFFIYAVIGMQVF-GKI-----------------ALNDTTEINR------------ 1443

Query: 292  EGPNNGITQFDNILFAVLTVFQCITMEGWTDLLY---------------NSNDAS---GN 333
               NN    F     AVL +F+C T E W D++                NS +     G+
Sbjct: 1444 ---NNNFQTFPQ---AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGS 1497

Query: 334  TWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 363
            ++   YFI   ++ +F ++NL + V+   F
Sbjct: 1498 SFAVFYFISFYMLCAFLIINLFVAVIMDNF 1527


>gi|110349767 calcium channel, voltage-dependent, L type, alpha 1S
            subunit [Homo sapiens]
          Length = 1873

 Score =  737 bits (1903), Expect = 0.0
 Identities = 384/825 (46%), Positives = 531/825 (64%), Gaps = 60/825 (7%)

Query: 1187 NKNANPDPLPKKEEEKKEEEEDDRGEDGPKP--------------MPPYSSMFILSTTNP 1232
            N N   DP P  +    +EE++      P+P              +P  SS FI S TN 
Sbjct: 728  NVNEVKDPYPSADFPGDDEEDEPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNK 787

Query: 1233 LRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEM 1292
            +R LCH I+N  +F   IL+ I +SS ALAAEDP++ ++ RN +L++FD  FT VFT E+
Sbjct: 788  IRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEI 847

Query: 1293 VIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLR 1352
            V+KM   G  LH+G++ R+ +N+LD +VV+ +L++     ++    I+ +K LRVLRVLR
Sbjct: 848  VLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSA----ISVVKILRVLRVLR 903

Query: 1353 PLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKE 1412
            PL+ I R   LK V  C+  ++  + NI++V  L  F+FA + VQLFKGKFF CTD SK 
Sbjct: 904  PLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKM 963

Query: 1413 FEKDCRGKYLLYEKNE---VKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHS 1469
             E++CRG Y +Y+  +   ++ R REW   +FH+DNVL A+++LFTVST EGWPQ+L  +
Sbjct: 964  TEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKA 1023

Query: 1470 VDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEK 1529
            +D+  E+ GP    R+EM+IF+++Y ++  FF +NIFV  +I+TFQEQG+   +   L+K
Sbjct: 1024 IDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDK 1083

Query: 1530 NERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYG 1589
            N+R C+ +A+ A+PL  ++P+N   +QY++W  V S  FEY + A+I LNTI L M+ Y 
Sbjct: 1084 NQRQCVQYALKARPLRCYIPKNP--YQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYN 1141

Query: 1590 ASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTE 1649
             S    +   + N+ FT +F+LE +LK+MAF    YF D WN+FDF+ V+GSI D++++E
Sbjct: 1142 QSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILSE 1201

Query: 1650 FGNNF-----------------------INLSFLRLFRAARLIKLLRQGYTIRILLWTFV 1686
                                        I+ +F RLFR  RLIKLL +   +R LLWTF+
Sbjct: 1202 IDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFI 1261

Query: 1687 QSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQAL 1746
            +SF+ALPYV LLI MLFFIYA+IGMQ+FG I +         D  QI  +NNF+TF QA+
Sbjct: 1262 KSFQALPYVALLIVMLFFIYAVIGMQMFGKIAL--------VDGTQINRNNNFQTFPQAV 1313

Query: 1747 MLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRE---CGNEFAYFYFVSFIFLCSFLML 1803
            +LLFR ATGEAW  I+L+C  GK CD  S     E   CG  FAY+YF+SF  LC+FL++
Sbjct: 1314 LLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVI 1373

Query: 1804 NLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPL 1863
            NLFVAVIMDNF+YLTRD SILGPHHLDE+  +WAEYDP A GRI + D+ +LLR I PPL
Sbjct: 1374 NLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPL 1433

Query: 1864 GLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAEL 1923
            G GK CPHRVACKRL+ M++P+  D TV FN+TL AL+RTAL IK      + +Q + EL
Sbjct: 1434 GFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTE---GNFEQANEEL 1490

Query: 1924 RKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQ 1968
            R  +  IW   S K LD ++ P    ++TVGK YA  +I E++R+
Sbjct: 1491 RAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRK 1535



 Score =  628 bits (1619), Expect = e-179
 Identities = 338/716 (47%), Positives = 457/716 (63%), Gaps = 55/716 (7%)

Query: 76  RSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDD 135
           R+LF  + +N +RK    I EW PFE +IL TI ANC+ LA+   +P+DD   ++  L+ 
Sbjct: 29  RALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEK 88

Query: 136 TEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATV---------- 185
            E +F+ +F  EA +KIIA GF FH+ +YLR+GWNV+DF +V  G+   +          
Sbjct: 89  LEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSH 148

Query: 186 -------GTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAIL 238
                  G   D++ LRA RVLRPL+LVSG+PSLQVVL SI KAM+PL  I LL+ F ++
Sbjct: 149 TAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVI 208

Query: 239 IFAIIGLEFYMGKFHTTCFEEGTD---DIQGESPAPCGTEEPARTCP-NGTKCQPYWEGP 294
           I+AIIGLE + GK H TC+  GTD    ++ E P+PC      R C  NG++C+  W GP
Sbjct: 209 IYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGP 268

Query: 295 NNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNL 354
           N+GIT FDN  F++LTV+QCITMEGWTD+LY  NDA GN W W+YF+ LI++GSFF+LNL
Sbjct: 269 NHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNL 328

Query: 355 VLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQR 414
           VLGVLSGEF KERE+ ++R  F KLR +QQ++ +L GYM WI++  EV+  ED  +G   
Sbjct: 329 VLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSWITQG-EVMDVEDFREG--- 384

Query: 415 HPFDGALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKER 474
                          K  L       + L +IA +          +  ++    + +  R
Sbjct: 385 ---------------KLSLDEGGSDTESLYEIAGL----------NKIIQFIRHWRQWNR 419

Query: 475 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEM 534
             R+    +VK++ FYW V+ +VALNTL +A  H+NQP WL+     A  + L LF +EM
Sbjct: 420 IFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEM 479

Query: 535 FIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVT 594
            +KMYGLG R YF S FN FDC V+   I E++       T  GISVLR +RLLRIFK+T
Sbjct: 480 LMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKIT 539

Query: 595 KYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF-DEGTPPTNFDT 653
           KYW SL NLV SLLNS++SI SLL LLFLFIV+FALLGMQLFGG+++F D     +NFD 
Sbjct: 540 KYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDN 599

Query: 654 FPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQ-GGMVFSIYFIVLTLFGNYTLLNVFLAI 712
           FP A+++VFQ+LTGEDW  +MY+GI + GG    GM+  IYFI+L + GNY LLNVFLAI
Sbjct: 600 FPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAI 659

Query: 713 AVDNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQ 768
           AVDNLA A+ LT  ++ +   A +K   + +K + + S    + M+  ++++ K +
Sbjct: 660 AVDNLAEAESLTSAQKAK---AEEKKRRKMSKGLPDKSEEEKSTMAKKLEQKPKGE 712



 Score =  221 bits (562), Expect = 8e-57
 Identities = 176/690 (25%), Positives = 323/690 (46%), Gaps = 104/690 (15%)

Query: 1200 EEKKEEEEDDRGEDGPKPMP-----PYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVI 1254
            E    ++E  R +   KP+P     P  ++F L+  NPLR+ C  I+  + FE  IL+ I
Sbjct: 2    EPSSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTI 61

Query: 1255 AMSSIALAAEDPV--QPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDL 1312
              + +ALA   P+    N   N  L   +Y F  VF+ E  +K+I  G + HQ AY R  
Sbjct: 62   FANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSG 121

Query: 1313 WNILDFIVVS-----------GALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLP 1361
            WN+LDF +V              + +     +SKG  ++ +K+LR  RVLRPL+ +  +P
Sbjct: 122  WNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLD-VKALRAFRVLRPLRLVSGVP 180

Query: 1362 KLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGK-----FFHCTD-----ESK 1411
             L+ V + +  ++  +F+I ++ +  + I+A++ ++LFKGK     +F  TD     E++
Sbjct: 181  SLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENE 240

Query: 1412 EFEKDCR---GKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKH 1468
            E     R   G+      +E +           H+DN  +++LT++   T EGW  VL +
Sbjct: 241  EPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVL-Y 299

Query: 1469 SVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGD--------- 1519
             V+    N+ P         I++V   ++  FF +N+ + ++   F ++ +         
Sbjct: 300  WVNDAIGNEWP--------WIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQ 351

Query: 1520 KMMEEYSLEKNERACIDFAISAKPL----------------------------------T 1545
            K+ E+  L+++ R  + +    + +                                   
Sbjct: 352  KLREKQQLDEDLRGYMSWITQGEVMDVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFI 411

Query: 1546 RHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVF 1605
            RH  Q  + F+++    V S  F + ++ ++ALNT+ +  + +   +       + N V 
Sbjct: 412  RHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVL 471

Query: 1606 TSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFG-NNFINLSFLRLFR 1664
             SLF+ E ++K+   G+  YF   +N FD   V   I +IL+ E G    + +S LR  R
Sbjct: 472  LSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIR 531

Query: 1665 AARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDE 1724
              R+ K+ +   ++  L+ + + S +++  + LL+ +   I+A++GMQ+FG    D ED 
Sbjct: 532  LLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGG-RYDFEDT 590

Query: 1725 DSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGN 1784
            +           +NF  F QAL+ +F+  TGE W ++M + +         G+L      
Sbjct: 591  E--------VRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGML------ 636

Query: 1785 EFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
                 YF+  +F+C ++++LN+F+A+ +DN
Sbjct: 637  --VCIYFI-ILFVCGNYILLNVFLAIAVDN 663



 Score =  127 bits (319), Expect = 1e-28
 Identities = 151/704 (21%), Positives = 294/704 (41%), Gaps = 121/704 (17%)

Query: 100  FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
            F ++++  +  N + +A E H   +    ++   D      + +F  E  +K+  LG   
Sbjct: 434  FYWLVILIVALNTLSIASEHH---NQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLR- 489

Query: 160  HKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT------LRAVRVLRPLKLVSGIPSLQ 213
                Y  + +N  D  VV +GIL  +  E    T      LR +R+LR  K+     SL 
Sbjct: 490  ---QYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLS 546

Query: 214  VVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCG 273
             ++ S++ ++  +  + LLLF  I+IFA++G++ + G++    FE+              
Sbjct: 547  NLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYD---FED-------------- 589

Query: 274  TEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGN 333
              E  R+                    FDN   A+++VFQ +T E WT ++YN   A G 
Sbjct: 590  -TEVRRS-------------------NFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGG 629

Query: 334  TWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 388
                     +YFI L + G++ +LN+ L +     A+       ++A  + ++++++ + 
Sbjct: 630  PSYPGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSKG 689

Query: 389  LNGYMEWISKAEEVILAEDETDGE--------QRHPFDGALRRTTIKKSKTDLLNPEEAE 440
            L    E   K+      E +  GE        +   F+  +          D    +E +
Sbjct: 690  LPDKSEE-EKSTMAKKLEQKPKGEGIPTTAKLKIDEFESNVNEVKDPYPSADFPGDDEED 748

Query: 441  DQLADIASVGSPFARASIKSAKL---ENSTFF-HKKERRMRFYIRRMVKTQAFYWTVLSL 496
            +    ++    P A   +K   +   E S+FF      ++R    R+V    F   +L  
Sbjct: 749  EPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLF 808

Query: 497  VALNTLCVAIVHYNQPEWL-SDFLYYAEFIFLGLFMSEMFIKM--YG--LGTRPYFHSSF 551
            + L++  +A     + + + +  L + +  F  +F  E+ +KM  YG  L    +  + F
Sbjct: 809  ILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYF 868

Query: 552  NCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSM 611
            N  D  V+  S+  +    ++      + +LR LR+LR  +       L+++V  +  ++
Sbjct: 869  NMLDLLVVAVSLISM---GLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAI 925

Query: 612  KSIISLLFLLFLFIVVFALLGMQLFGGQFN-------------------FDEGTPPT--- 649
             +I +++ +  L   +FA +G+QLF G+F                    + +G P     
Sbjct: 926  STIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIEL 985

Query: 650  ----------NFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQ----GGVQGGMV-FSIYF 694
                      +FD   +A+M++F + T E W +++Y  I S     G +    V  +I+F
Sbjct: 986  RHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFF 1045

Query: 695  IVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKL 738
            I+  +   + ++N+F+   +        +T  EQ E E  N +L
Sbjct: 1046 IIYIILIAFFMMNIFVGFVI--------VTFQEQGETEYKNCEL 1081



 Score =  108 bits (270), Expect = 6e-23
 Identities = 80/301 (26%), Positives = 138/301 (45%), Gaps = 50/301 (16%)

Query: 472  KERRMRFYIRR---------MVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 522
            K R +R YI +         +V +  F + + +L+ LNT+C+ + HYNQ E ++      
Sbjct: 1094 KARPLRCYIPKNPYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDIL 1153

Query: 523  EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVI----------- 571
               F  +F  EM +K+     R YF   +N FD  ++IGSI +VI + I           
Sbjct: 1154 NVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLY 1213

Query: 572  ---------KPGTSFGIS--VLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFL 620
                      P  S  IS    R  R++R+ K+      +R L+ + + S +++  +  L
Sbjct: 1214 CLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALL 1273

Query: 621  LFLFIVVFALLGMQLFGGQFNFDEGTP---PTNFDTFPAAIMTVFQILTGEDWNEVMY-- 675
            + +   ++A++GMQ+F G+    +GT      NF TFP A++ +F+  TGE W E++   
Sbjct: 1274 IVMLFFIYAVIGMQMF-GKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLAC 1332

Query: 676  ----------DGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTK 725
                      D    +    G      YFI   +   + ++N+F+A+ +DN      LT+
Sbjct: 1333 SYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNF---DYLTR 1389

Query: 726  D 726
            D
Sbjct: 1390 D 1390



 Score =  102 bits (253), Expect = 6e-21
 Identities = 86/326 (26%), Positives = 154/326 (47%), Gaps = 23/326 (7%)

Query: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
            S F+FS  N +R    +I     F   IL  I+ +   LA E  +  D     ++ L   
Sbjct: 778  SFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMR--NQILKHF 835

Query: 137  EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
            +  F  +F  E  +K+   G   HKGS+ RN +N++D +VV   ++ ++G E      ++
Sbjct: 836  DIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLI-SMGLESSAISVVK 894

Query: 193  TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I L+      +FA IG++ + GKF
Sbjct: 895  ILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKF 954

Query: 253  HTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVF 312
                      D+   +   C          +  + +       +    FDN+L A++++F
Sbjct: 955  FR------CTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLF 1008

Query: 313  QCITMEGWTDLLYNSNDAS----GNTWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEF 363
               T EGW  LLY + D++    G  +N      ++FI  II+ +FFM+N+ +G +   F
Sbjct: 1009 TVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTF 1068

Query: 364  AKERERVENRRAFLKLRRQQQIEREL 389
             +E+   E +   L   ++Q ++  L
Sbjct: 1069 -QEQGETEYKNCELDKNQRQCVQYAL 1093



 Score = 99.4 bits (246), Expect = 4e-20
 Identities = 80/300 (26%), Positives = 152/300 (50%), Gaps = 51/300 (17%)

Query: 1237 CHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKM 1296
            CH I+  + F   +++++A++++++A+E   QP      +    + V   +FT EM++KM
Sbjct: 425  CHDIVKSKVFYWLVILIVALNTLSIASEHHNQP-LWLTRLQDIANRVLLSLFTTEMLMKM 483

Query: 1297 IDLGLVLHQGAYFRDLWNILD-FIVVSGAL-VAFAFTGNSKGKDINTIKSLRVLRVLRPL 1354
              LGL      YF  ++N  D F+V SG L +    +G      I+ ++ +R+LR+ +  
Sbjct: 484  YGLGL----RQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKIT 539

Query: 1355 KTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFE 1414
            K    L  L A    ++NS++++ ++L++  LF+ IFA++ +QLF G++           
Sbjct: 540  KYWTSLSNLVA---SLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYD---------- 586

Query: 1415 KDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
                     +E  EV+           ++DN   AL+++F V TGE W  ++ + + A  
Sbjct: 587  ---------FEDTEVR---------RSNFDNFPQALISVFQVLTGEDWTSMMYNGIMA-- 626

Query: 1475 ENQGPS-PGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERA 1533
               GPS PG  M + I++++ FV   +  +N+F+A+ +       D + E  SL   ++A
Sbjct: 627  -YGGPSYPG--MLVCIYFIILFVCGNYILLNVFLAIAV-------DNLAEAESLTSAQKA 676



 Score = 75.1 bits (183), Expect = 7e-13
 Identities = 71/322 (22%), Positives = 129/322 (40%), Gaps = 69/322 (21%)

Query: 1544 LTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKF---YGASVAYENALRV 1600
            LT   P  K       W+     PFE  I+  I  N + L +        + +    L  
Sbjct: 34   LTLENPLRKACISIVEWK-----PFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEK 88

Query: 1601 FNIVFTSLFSLECVLKVMAFGIL----NYFRDAWNIFDFVTVLGSITDILVTEFG----- 1651
                F  +FS+E  +K++A+G L     Y R  WN+ DF  V   +  +++ +       
Sbjct: 89   LEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSH 148

Query: 1652 -------NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1704
                      +++  LR FR  R ++L+    +++++L +  ++   L ++ LL+  +  
Sbjct: 149  TAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVI 208

Query: 1705 IYAIIGMQVFGN--------IGIDVEDEDSDEDEFQITEHNN------------------ 1738
            IYAIIG+++F          IG D+     +E+        +                  
Sbjct: 209  IYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGP 268

Query: 1739 ------FRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFV 1792
                  F  F  +++ +++  T E W +++           N  I     GNE+ + YFV
Sbjct: 269  NHGITHFDNFGFSMLTVYQCITMEGWTDVLYWV--------NDAI-----GNEWPWIYFV 315

Query: 1793 SFIFLCSFLMLNLFVAVIMDNF 1814
            + I L SF +LNL + V+   F
Sbjct: 316  TLILLGSFFILNLVLGVLSGEF 337



 Score = 67.4 bits (163), Expect = 2e-10
 Identities = 68/308 (22%), Positives = 119/308 (38%), Gaps = 87/308 (28%)

Query: 100  FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
            FEY++ A I+ N I L ++ +   +    +S+ L+     F  IF  E  +K++A    F
Sbjct: 1120 FEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVA---FTIIFTLEMILKLMA----F 1172

Query: 160  HKGSYLRNGWNVMDFVVVLTGILATVGTEFDL---------------------------- 191
                Y  + WNV DF++V+  I+  + +E D                             
Sbjct: 1173 KARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISS 1232

Query: 192  RTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGK 251
               R  RV+R +KL+S    ++ +L + +K+   L  + LL+     I+A+IG++ + GK
Sbjct: 1233 AFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF-GK 1291

Query: 252  FHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTV 311
                                           +GT+        NN    F     AVL +
Sbjct: 1292 I---------------------------ALVDGTQI-----NRNNNFQTFPQ---AVLLL 1316

Query: 312  FQCITMEGWTDLLY----------------NSNDASGNTWNWLYFIPLIIIGSFFMLNLV 355
            F+C T E W ++L                       G  + + YFI   ++ +F ++NL 
Sbjct: 1317 FRCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLF 1376

Query: 356  LGVLSGEF 363
            + V+   F
Sbjct: 1377 VAVIMDNF 1384


>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
            [Homo sapiens]
          Length = 2005

 Score =  327 bits (839), Expect = 6e-89
 Identities = 234/787 (29%), Positives = 391/787 (49%), Gaps = 71/787 (9%)

Query: 1233 LRRLCHYILNLRYFEMCILMVIAMSSIALAAEDP-VQPNAPRNNVLRYFDYVFTGVFTFE 1291
            LR+ C+ I+   +FE  I+ +I +SS ALA ED  ++       +L Y D VFT +F  E
Sbjct: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256

Query: 1292 MVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKG-KDINTIKSLRVLRV 1350
            M++K +  G  +    YF + W  LDF++V  +LV+   T N+ G  ++  IKSLR LR 
Sbjct: 1257 MLLKWVAYGFQV----YFTNAWCWLDFLIVDVSLVSL--TANALGYSELGAIKSLRTLRA 1310

Query: 1351 LRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTD-- 1408
            LRPL+ + R   ++ V + ++ ++ ++ N+L+V ++F  IF+++ V LF GKF+HC +  
Sbjct: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYT 1370

Query: 1409 ESKEFEKDCRGKY----LLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQ 1464
              + F+      Y     L E N+       WK  + ++DNV    L+L  V+T +GW  
Sbjct: 1371 TGEMFDVSVVNNYSECKALIESNQT----ARWKNVKVNFDNVGLGYLSLLQVATFKGWMD 1426

Query: 1465 VLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDK---- 1520
            ++  +VD+      P     + M +++V++ +   FF +N+F+ +II  F +Q  K    
Sbjct: 1427 IMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQ 1486

Query: 1521 ---MMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIA 1577
               M EE     N    +      KP+ R  P NK  FQ  ++ FV    F+ +IM +I 
Sbjct: 1487 DIFMTEEQKKYYNAMKKLGSKKPQKPIPR--PANK--FQGMVFDFVTKQVFDISIMILIC 1542

Query: 1578 LNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVT 1637
            LN + +M++    S    N L   N+VF  LF+ ECVLK+++     YF   WNIFDFV 
Sbjct: 1543 LNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYY-YFTIGWNIFDFVV 1601

Query: 1638 VLGSITDILVTEFGNNFI----NLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALP 1693
            V+ SI  + + E    +         +RL R  R+++L++    IR LL+  + S  AL 
Sbjct: 1602 VILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1661

Query: 1694 YVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSA 1753
             + LL+ ++ FIYAI GM  F  +          + E  I +  NF TF  +++ LF+  
Sbjct: 1662 NIGLLLFLVMFIYAIFGMSNFAYV----------KREVGIDDMFNFETFGNSMICLFQIT 1711

Query: 1754 TGEAWHNIMLSCLSGKP--CDKN----SGILTRECGN-EFAYFYFVSFIFLCSFLMLNLF 1806
            T   W  ++   L+  P  CD +       +  +CGN     F+FVS+I +   +++N++
Sbjct: 1712 TSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMY 1771

Query: 1807 VAVIMDNFEYLTRDSS-ILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGL 1865
            +AVI++NF   T +S+  L     + +  VW ++DP A   I +  +      + PPL +
Sbjct: 1772 IAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLI 1831

Query: 1866 GKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDA-ELR 1924
             K  P++V   +L+ MDLP+   + +H    L A  +  L         +  +MDA  ++
Sbjct: 1832 AK--PNKV---QLIAMDLPMVSGDRIHCLDILFAFTKRVL--------GESGEMDALRIQ 1878

Query: 1925 KEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAM-----RE 1979
             E   +  N S+ + + + T  K     V  I        Y  + K KK+ ++      +
Sbjct: 1879 MEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGK 1938

Query: 1980 EQDRTPL 1986
            E D TP+
Sbjct: 1939 ECDGTPI 1945



 Score =  154 bits (390), Expect = 7e-37
 Identities = 103/388 (26%), Positives = 179/388 (46%), Gaps = 62/388 (15%)

Query: 77  SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
           +L++ +  N +RK A KI     F  +I+ TI+ NC+ + +    PD  K        + 
Sbjct: 108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP-PDWTK--------NV 158

Query: 137 EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTLRA 196
           E  F GI+ FE+ IKI+A GF     ++LR+ WN +DF V+    +       ++  LR 
Sbjct: 159 EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVNLGNVSALRT 218

Query: 197 VRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTC 256
            RVLR LK +S IP L+ ++ ++++++  L  + +L  F + +FA+IGL+ +MG     C
Sbjct: 219 FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC 278

Query: 257 FEEGTDD-------------------------------------------IQGESPA-PC 272
            +   D+                                           ++G++ A  C
Sbjct: 279 LQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLC 338

Query: 273 GTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASG 332
           G    A  CP G  C      PN G T FD   +A L++F+ +T + W +L   +  A+G
Sbjct: 339 GNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAG 398

Query: 333 NTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGY 392
            T+  ++F+ +I +GSF+++NL+L V++  + ++ +          L   +Q E E    
Sbjct: 399 KTY-MIFFVLVIFLGSFYLINLILAVVAMAYEEQNQAT--------LEEAEQKEAEFQQM 449

Query: 393 MEWISKAEEVILAEDETDGEQRHPFDGA 420
           +E + K +E   A       +   F GA
Sbjct: 450 LEQLKKQQEEAQAAAAAASAESRDFSGA 477



 Score =  125 bits (314), Expect = 5e-28
 Identities = 84/288 (29%), Positives = 144/288 (50%), Gaps = 38/288 (13%)

Query: 497  VALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDC 556
            + LNTL +A+ HY   E  S  L     +F G+F +EMF+K+  +    YF   +N FD 
Sbjct: 769  IVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDG 828

Query: 557  GVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIIS 616
             ++  S+ E+  A ++     G+SVLR+ RLLR+FK+ K W +L  L+  + NS+ ++ +
Sbjct: 829  FIVSLSLMELGLANVE-----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGN 883

Query: 617  LLFLLFLFIVVFALLGMQLFGGQF-------NFDEGTPPTNFDTFPAAIMTVFQILTGED 669
            L  +L + + +FA++GMQLFG  +       + D   P  +   F  + + VF++L GE 
Sbjct: 884  LTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGE- 942

Query: 670  WNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQE 729
            W E M+D ++    V G  +    F+++ + GN  +LN+FLA+ + + ++      D+  
Sbjct: 943  WIETMWDCME----VAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDN 998

Query: 730  EEEAAN---------------------QKLALQKAKEVAEVSPLSAAN 756
            E                          QK  ++K K + E+ PL   N
Sbjct: 999  EMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLN 1046



 Score =  114 bits (286), Expect = 8e-25
 Identities = 86/306 (28%), Positives = 148/306 (48%), Gaps = 27/306 (8%)

Query: 87   VRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCF 146
            +RK   KI E   FE  I+  I+ +   LA E    +  KT +   L+  +  F  IF  
Sbjct: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKT-IKTMLEYADKVFTYIFIL 1255

Query: 147  EAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD------LRTLRAVRVL 200
            E  +K +A GF      Y  N W  +DF++V   +++             +++LR +R L
Sbjct: 1256 EMLLKWVAYGFQV----YFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRAL 1311

Query: 201  RPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEG 260
            RPL+ +S    ++VV+ +++ A+  ++ + L+     LIF+I+G+  + GKF+  C    
Sbjct: 1312 RPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY-HCINYT 1370

Query: 261  TDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGW 320
            T ++   S     +E  A    N T     W+   N    FDN+    L++ Q  T +GW
Sbjct: 1371 TGEMFDVSVVNNYSECKALIESNQT---ARWK---NVKVNFDNVGLGYLSLLQVATFKGW 1424

Query: 321  TDLLYNSNDA---------SGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVE 371
             D++Y + D+           N + +LYF+  II GSFF LNL +GV+   F +++++  
Sbjct: 1425 MDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFG 1484

Query: 372  NRRAFL 377
             +  F+
Sbjct: 1485 GQDIFM 1490



 Score =  112 bits (280), Expect = 4e-24
 Identities = 75/253 (29%), Positives = 127/253 (50%), Gaps = 23/253 (9%)

Query: 1563 VVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGI 1622
            V+ P  +  I   I LNT+ + M+ Y  +  + + L V N+VFT +F+ E  LK++A   
Sbjct: 756  VMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDP 815

Query: 1623 LNYFRDAWNIFDFVTVLGSITDILVTEFG-NNFINLSFLRLFRAARLIKLLRQGYTIRIL 1681
              YF++ WNIFD     G I  + + E G  N   LS LR FR  R+ KL +   T+ +L
Sbjct: 816  YYYFQEGWNIFD-----GFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNML 870

Query: 1682 LWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRT 1741
            +     S  AL  + L++A++ FI+A++GMQ+FG    +   + S++ E       +   
Sbjct: 871  IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCEL---PRWHMHD 927

Query: 1742 FFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFL 1801
            FF + +++FR   GE W   M  C+                G       F+  + + + +
Sbjct: 928  FFHSFLIVFRVLCGE-WIETMWDCM-------------EVAGQTMCLTVFMMVMVIGNLV 973

Query: 1802 MLNLFVAVIMDNF 1814
            +LNLF+A+++ +F
Sbjct: 974  VLNLFLALLLSSF 986



 Score =  104 bits (260), Expect = 9e-22
 Identities = 61/180 (33%), Positives = 101/180 (56%), Gaps = 16/180 (8%)

Query: 1223 SMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDY 1282
            +++IL+  NP+R+L   IL    F M I+  I  + + +   +P  P+  +N      +Y
Sbjct: 108  ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP--PDWTKN-----VEY 160

Query: 1283 VFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVA-FAFTGNSKGKDINT 1341
             FTG++TFE +IK++  G  L    + RD WN LDF V++ A V  F   GN        
Sbjct: 161  TFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVNLGN-------- 212

Query: 1342 IKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKG 1401
            + +LR  RVLR LKTI  +P LK +   ++ S+K + +++I+ +  + +FA++ +QLF G
Sbjct: 213  VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 272



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 64/293 (21%), Positives = 133/293 (45%), Gaps = 43/293 (14%)

Query: 496  LVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFD 555
            L++   L    ++  Q + +   L YA+ +F  +F+ EM +K    G + YF +++   D
Sbjct: 1219 LLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLD 1278

Query: 556  CGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSII 615
              ++  S+  +    +       I  LR LR LR  +    +  +R +V +LL ++ SI+
Sbjct: 1279 FLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIM 1338

Query: 616  SLLFLLFLFIVVFALLGMQLFGGQF----NFDEG-------------------------- 645
            ++L +  +F ++F+++G+ LF G+F    N+  G                          
Sbjct: 1339 NVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKALIESNQTARW 1398

Query: 646  -TPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKS-----QGGVQGGMVFSIYFIVLTL 699
                 NFD      +++ Q+ T + W ++MY  + S     Q   +  +   +YF++  +
Sbjct: 1399 KNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFII 1458

Query: 700  FGNYTLLNVFLAIAVDNLANAQE-------LTKDEQEEEEAANQKLALQKAKE 745
            FG++  LN+F+ + +DN    ++          +EQ++   A +KL  +K ++
Sbjct: 1459 FGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1511



 Score = 85.1 bits (209), Expect = 7e-16
 Identities = 66/273 (24%), Positives = 131/273 (47%), Gaps = 30/273 (10%)

Query: 484  VKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGT 543
            V  Q F  +++ L+ LN + + +   +Q + +++ LY+   +F+ LF  E  +K+  L  
Sbjct: 1528 VTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY 1587

Query: 544  RPYFHSSFNCFDCGVIIGSIF-----EVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWA 598
              YF   +N FD  V+I SI      E+I       T F   V+R  R+ RI ++ K   
Sbjct: 1588 Y-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLF--RVIRLARIGRILRLIKGAK 1644

Query: 599  SLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG---GQFNFDEGTPPTNFDTFP 655
             +R L+ +L+ S+ ++ ++  LLFL + ++A+ GM  F     +   D+     NF+TF 
Sbjct: 1645 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDD---MFNFETFG 1701

Query: 656  AAIMTVFQILTGEDWNEVM----------------YDGIKSQGGVQGGMVFSIYFIVLTL 699
             +++ +FQI T   W+ ++                + G   +G      V   +F+   +
Sbjct: 1702 NSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYII 1761

Query: 700  FGNYTLLNVFLAIAVDNLANAQELTKDEQEEEE 732
                 ++N+++A+ ++N + A E + +   E++
Sbjct: 1762 ISFLVVVNMYIAVILENFSVATEESAEPLSEDD 1794



 Score = 80.9 bits (198), Expect = 1e-14
 Identities = 70/285 (24%), Positives = 126/285 (44%), Gaps = 51/285 (17%)

Query: 89  KYAKKITEWPPF-EYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT----EPYFIGI 143
           K+   +    PF +  I   I+ N + +A+E +       PM+E+           F GI
Sbjct: 749 KHLVNLVVMDPFVDLAITICIVLNTLFMAMEHY-------PMTEQFSSVLSVGNLVFTGI 801

Query: 144 FCFEAGIKIIALGFAFHKGSYLRNGWNVMD-FVVVLTGILATVGTEFDLRTLRAVRVLRP 202
           F  E  +KIIA+   +    Y + GWN+ D F+V L+ +   +     L  LR+ R+LR 
Sbjct: 802 FTAEMFLKIIAMDPYY----YFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRV 857

Query: 203 LKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTD 262
            KL    P+L +++K I  ++  L  + L+L   + IFA++G++ + GK +  C      
Sbjct: 858 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKEC------ 910

Query: 263 DIQGESPAPCGTEEPARTCPNGTKCQ-PYWEGPNNGITQFDNILFAVLTVFQCITMEGWT 321
                             C     C+ P W           +   + L VF+ +  E W 
Sbjct: 911 -----------------VCKISNDCELPRW--------HMHDFFHSFLIVFRVLCGE-WI 944

Query: 322 DLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKE 366
           + +++  + +G T     F+ +++IG+  +LNL L +L   F+ +
Sbjct: 945 ETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSD 989



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 70/283 (24%), Positives = 132/283 (46%), Gaps = 45/283 (15%)

Query: 1233 LRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPR-NNVLRYFDYVFTGVFTFE 1291
            ++ L + ++   + ++ I + I ++++ +A E    P   + ++VL   + VFTG+FT E
Sbjct: 748  VKHLVNLVVMDPFVDLAITICIVLNTLFMAMEH--YPMTEQFSSVLSVGNLVFTGIFTAE 805

Query: 1292 MVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVL 1351
            M +K+I     +    YF++ WNI D  +VS +L+           ++  +  LR  R+L
Sbjct: 806  MFLKII----AMDPYYYFQEGWNIFDGFIVSLSLMELGLA------NVEGLSVLRSFRLL 855

Query: 1352 RPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESK 1411
            R  K  K  P L  +   + NS+  + N+ +V  + +FIFAVV +QLF   +  C     
Sbjct: 856  RVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV---C 912

Query: 1412 EFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVD 1471
            +   DC                  W  ++F +     + L +F V  GE W + +   ++
Sbjct: 913  KISNDCELP--------------RWHMHDFFH-----SFLIVFRVLCGE-WIETMWDCME 952

Query: 1472 ATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITF 1514
                      G  M +++F +V  V+     +N+F+AL++ +F
Sbjct: 953  VA--------GQTMCLTVFMMV-MVIGNLVVLNLFLALLLSSF 986



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 53/174 (30%), Positives = 81/174 (46%), Gaps = 21/174 (12%)

Query: 100  FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
            F+  I+  I  N + + +E    DD    M+  L      FI +F  E  +K+I+L +  
Sbjct: 1533 FDISIMILICLNMVTMMVET---DDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYY- 1588

Query: 160  HKGSYLRNGWNVMDFVVVLTGILATVGTEFD---------LRTLRAVRVLRPLKLVSGIP 210
                Y   GWN+ DFVVV+  I+     E            R +R  R+ R L+L+ G  
Sbjct: 1589 ----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1644

Query: 211  SLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDI 264
             ++ +L ++M ++  L  IGLLLF  + I+AI G    M  F     E G DD+
Sbjct: 1645 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFG----MSNFAYVKREVGIDDM 1694



 Score = 65.1 bits (157), Expect = 8e-10
 Identities = 55/191 (28%), Positives = 86/191 (45%), Gaps = 26/191 (13%)

Query: 1561 QFVVSPPFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKV 1617
            + +V   F   IM  I  N + + M     +  +V Y          FT +++ E ++K+
Sbjct: 124  KILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEY---------TFTGIYTFESLIKI 174

Query: 1618 MAFGI----LNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLR 1673
            +A G       + RD WN  DF      IT   VTEF N   N+S LR FR  R +K + 
Sbjct: 175  LARGFCLEDFTFLRDPWNWLDFTV----ITFAYVTEFVN-LGNVSALRTFRVLRALKTIS 229

Query: 1674 QGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-GNIGIDVEDEDSDEDEFQ 1732
                ++ ++   +QS K L  V +L      ++A+IG+Q+F GN+         D   F+
Sbjct: 230  VIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFE 289

Query: 1733 ITEHNNFRTFF 1743
            I    N  +FF
Sbjct: 290  I----NITSFF 296



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 42/152 (27%), Positives = 70/152 (46%), Gaps = 14/152 (9%)

Query: 491 WTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLG----TRPY 546
           + +L +  + T CV +   N P+W  +     E+ F G++  E  IK+   G       +
Sbjct: 131 FNMLIMCTILTNCVFMTMSNPPDWTKN----VEYTFTGIYTFESLIKILARGFCLEDFTF 186

Query: 547 FHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVS 606
               +N  D  VI    F  +   +  G    +S LR  R+LR  K       L+ +V +
Sbjct: 187 LRDPWNWLDFTVIT---FAYVTEFVNLGN---VSALRTFRVLRALKTISVIPGLKTIVGA 240

Query: 607 LLNSMKSIISLLFLLFLFIVVFALLGMQLFGG 638
           L+ S+K +  ++ L    + VFAL+G+QLF G
Sbjct: 241 LIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 272



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 28/107 (26%), Positives = 58/107 (54%), Gaps = 5/107 (4%)

Query: 649 TNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNV 708
           T+FDTF  A +++F+++T + W  +    +++      G  + I+F+++   G++ L+N+
Sbjct: 365 TSFDTFSWAFLSLFRLMTQDFWENLYQLTLRA-----AGKTYMIFFVLVIFLGSFYLINL 419

Query: 709 FLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAA 755
            LA+         + T +E E++EA  Q++  Q  K+  E    +AA
Sbjct: 420 ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAA 466



 Score = 37.4 bits (85), Expect = 0.17
 Identities = 26/80 (32%), Positives = 37/80 (46%), Gaps = 14/80 (17%)

Query: 1736 HNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFI 1795
            + +F TF  A + LFR  T + W N+    L             R  G  +  F FV  I
Sbjct: 364  YTSFDTFSWAFLSLFRLMTQDFWENLYQLTL-------------RAAGKTYMIF-FVLVI 409

Query: 1796 FLCSFLMLNLFVAVIMDNFE 1815
            FL SF ++NL +AV+   +E
Sbjct: 410  FLGSFYLINLILAVVAMAYE 429


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.137    0.414 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,120,431
Number of Sequences: 37866
Number of extensions: 4764812
Number of successful extensions: 46148
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 333
Number of HSP's successfully gapped in prelim test: 839
Number of HSP's that attempted gapping in prelim test: 28232
Number of HSP's gapped (non-prelim): 11120
length of query: 2261
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2143
effective length of database: 13,779,330
effective search space: 29529104190
effective search space used: 29529104190
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.