Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 11321597
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11321597 kinase insert domain receptor precursor [Homo
sapiens]
(1356 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11321597 kinase insert domain receptor precursor [Homo sapiens] 2737 0.0
gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor [... 1042 0.0
gi|103472027 fms-related tyrosine kinase 4 isoform 2 precursor [... 1041 0.0
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [... 1039 0.0
gi|229892300 fms-related tyrosine kinase 1 isoform 3 precursor [... 366 e-101
gi|5453870 platelet-derived growth factor receptor alpha precurs... 366 e-101
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge... 347 6e-95
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene... 346 8e-95
gi|27262659 colony stimulating factor 1 receptor precursor [Homo... 340 7e-93
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 334 3e-91
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 334 3e-91
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 334 3e-91
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 334 3e-91
gi|121114304 fms-related tyrosine kinase 3 [Homo sapiens] 330 4e-90
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 329 1e-89
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 328 2e-89
gi|229892220 fms-related tyrosine kinase 1 isoform 2 precursor [... 328 2e-89
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 328 2e-89
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 328 2e-89
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 328 2e-89
gi|4505683 platelet-derived growth factor receptor beta precurso... 325 2e-88
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 325 2e-88
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 324 3e-88
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 323 9e-88
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 323 9e-88
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 322 2e-87
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 319 1e-86
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 319 1e-86
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 318 2e-86
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 314 4e-85
>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
Length = 1356
Score = 2737 bits (7095), Expect = 0.0
Identities = 1356/1356 (100%), Positives = 1356/1356 (100%)
Query: 1 MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLD 60
MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLD
Sbjct: 1 MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLD 60
Query: 61 WLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQD 120
WLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQD
Sbjct: 61 WLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQD 120
Query: 121 YRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWD 180
YRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWD
Sbjct: 121 YRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWD 180
Query: 181 SKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGE 240
SKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGE
Sbjct: 181 SKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGE 240
Query: 241 KLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRS 300
KLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRS
Sbjct: 241 KLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRS 300
Query: 301 DQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPP 360
DQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPP
Sbjct: 301 DQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPP 360
Query: 361 EIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVP 420
EIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVP
Sbjct: 361 EIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVP 420
Query: 421 PQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPY 480
PQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPY
Sbjct: 421 PQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPY 480
Query: 481 PCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGE 540
PCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGE
Sbjct: 481 PCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGE 540
Query: 541 RVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPT 600
RVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPT
Sbjct: 541 RVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPT 600
Query: 601 PVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLT 660
PVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLT
Sbjct: 601 PVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLT 660
Query: 661 VLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNR 720
VLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNR
Sbjct: 661 VLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNR 720
Query: 721 NLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWL 780
NLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWL
Sbjct: 721 NLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWL 780
Query: 781 LLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPL 840
LLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPL
Sbjct: 781 LLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPL 840
Query: 841 GRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVN 900
GRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVN
Sbjct: 841 GRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVN 900
Query: 901 LLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLK 960
LLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLK
Sbjct: 901 LLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLK 960
Query: 961 RRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLA 1020
RRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLA
Sbjct: 961 RRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLA 1020
Query: 1021 SRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDR 1080
SRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDR
Sbjct: 1021 SRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDR 1080
Query: 1081 VYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTML 1140
VYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTML
Sbjct: 1081 VYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTML 1140
Query: 1141 DCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVS 1200
DCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVS
Sbjct: 1141 DCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVS 1200
Query: 1201 CMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDS 1260
CMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDS
Sbjct: 1201 CMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDS 1260
Query: 1261 GMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYS 1320
GMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYS
Sbjct: 1261 GMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYS 1320
Query: 1321 SEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV 1356
SEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV
Sbjct: 1321 SEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV 1356
>gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor [Homo
sapiens]
Length = 1363
Score = 1042 bits (2694), Expect = 0.0
Identities = 592/1333 (44%), Positives = 790/1333 (59%), Gaps = 71/1333 (5%)
Query: 1 MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLD 60
MQ L + LWLC+ V S+ P L+I ++ I +L I+CRGQ L+
Sbjct: 1 MQRGAALCLRLWLCLGLLDGLVS--GYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLE 58
Query: 61 WLWPNNQSG-------SEQRVEVTECSDG---LFCKTLTIPKVIGNDTGAYKCFYR---- 106
W WP Q SE V +C +CK L + +V NDTG+Y C+Y+
Sbjct: 59 WAWPGAQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKA 118
Query: 107 --ETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCAR 164
E A+ YV+V+D+ PFI + N+ + +PCL SI LNV+L R
Sbjct: 119 RIEGTTAASSYVFVRDFEQPFINKPDT------LLVNRKDAMWVPCLVSIPGLNVTL--R 170
Query: 165 YPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIY 224
PDG + WD ++G + + ++ A + CE D+ + S ++V + G +Y
Sbjct: 171 SQSSVLWPDGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELY 230
Query: 225 DVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSE 284
D+ L P +EL VGEKLVLNCT E N G+ F+W+YP + + K V Q+ +E
Sbjct: 231 DIQLLPRKSLELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTE 290
Query: 285 MKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATV 344
+ S LTI V++ D G Y C A++G+ + ST V VHE PF++ ++EAT
Sbjct: 291 LS---SILTIHNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATA 347
Query: 345 G-ERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNP 403
G E V++P K YPPPE +WYK+G L H+ H L + EV+E TG YT+ L N
Sbjct: 348 GDELVKLPVKLAAYPPPEFQWYKDGKALSGRHS---PHALVLKEVTEASTGTYTLALWNS 404
Query: 404 ISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLE 463
+ +++ + LVV VPPQI EK SP Y + Q LTCT Y +P P I W+W+
Sbjct: 405 AAGLRRNISLELVVNVPPQIHEKEASSP-SIYSRHSRQALTCTAYGVPLPLSIQWHWRPW 463
Query: 464 EECANEPSQAVSVTNPYP----CEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVI 519
C +++ C +WR+V N IE +EGKNKTVS LVI
Sbjct: 464 TPCKMFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVI 523
Query: 520 QAANVSALYKCEAVNKVGRGERVISFHVTRGPE---ITLQPDMQPTEQESVSLWCTADRS 576
Q ANVSA+YKC NKVG+ ER+I F+VT P+ I +P + E + V L C AD
Sbjct: 524 QNANVSAMYKCVVSNKVGQDERLIYFYVTTIPDGFTIESKPSEELLEGQPVLLSCQADSY 583
Query: 577 TFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDI--------LIME 628
+E+L WY+L L G CKN+ L AT + S ++ L +
Sbjct: 584 KYEHLRWYRLNLSTLHDAHGNPLLLDCKNVH----LFATPLAASLEEVAPGARHATLSLS 639
Query: 629 LKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSC 688
+ + + +G YVC QDR++ +HC + L+V AP +T NL + ++ +S+E+ C
Sbjct: 640 IPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQC 699
Query: 689 TASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKV 748
+G P I+W+KD L E SG+ L D N+ L+I+RVR+ED G Y C C+ GC
Sbjct: 700 LVAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNS 759
Query: 749 EAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDP 808
A +EG+++K ++EI+ILVGT VIA+FFW+LL++I ++R ++KTGYLSI+MDP
Sbjct: 760 SASVAVEGSEDKGSMEIVILVGTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDP 819
Query: 809 DELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVK 868
E+PL+E CE L YDAS+WEFPR+RL LG+ LG GAFG+V+EA AFGI K ++C TVAVK
Sbjct: 820 GEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVK 879
Query: 869 MLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYL 928
MLKEGAT SEHRALMSELKILIHIG+HLNVVNLLGACTKP GPLMVIVEFCK+GNLS +L
Sbjct: 880 MLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFL 939
Query: 929 RSKRNEFVPYKTKGARFR-QGKDYVGAIPVDLKR--RLDSITSSQSSASSGFVEEKSLSD 985
R+KR+ F P K R + + V +D +R D + ++ S + G S
Sbjct: 940 RAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRAS--- 996
Query: 986 VEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKIC 1045
++ EDL+ LT+E L+CYSFQVA+GMEFLASRKCIHRDLAARNILLSE +VVKIC
Sbjct: 997 --PDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKIC 1054
Query: 1046 DFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASP 1105
DFGLARDIYKDPDYVRKG ARLPLKWMAPE+IFD+VYT QSDVWSFGVLLWEIFSLGASP
Sbjct: 1055 DFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASP 1114
Query: 1106 YPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQ 1165
YPGV+I+EEFC+RL++GTRMRAP+ TP + + ML+CW G+P RP FSELVE LG+LLQ
Sbjct: 1115 YPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQ 1174
Query: 1166 ANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDP--------KFHYDNT 1217
Q+ ++ + P S + S EE S + T + + + P Y N
Sbjct: 1175 GRGLQEEEEVCMAPRS-SQSSEEGSFSQVSTMALHIAQADAEDSPPSLQRHSLAARYYNW 1233
Query: 1218 AGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTK 1277
L +KTFE+ P+ P DNQTDSGMVLASEE + +E R +
Sbjct: 1234 VSFPGCLARGAETRGSSRMKTFEEFPM-TPTTYKGSVDNQTDSGMVLASEEFEQIESRHR 1292
Query: 1278 LSPSFGGMVPSKS 1290
F P ++
Sbjct: 1293 QESGFSCKGPGQN 1305
>gi|103472027 fms-related tyrosine kinase 4 isoform 2 precursor [Homo
sapiens]
Length = 1298
Score = 1041 bits (2692), Expect = 0.0
Identities = 591/1325 (44%), Positives = 787/1325 (59%), Gaps = 71/1325 (5%)
Query: 1 MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLD 60
MQ L + LWLC+ V S+ P L+I ++ I +L I+CRGQ L+
Sbjct: 1 MQRGAALCLRLWLCLGLLDGLVS--GYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLE 58
Query: 61 WLWPNNQSG-------SEQRVEVTECSDG---LFCKTLTIPKVIGNDTGAYKCFYR---- 106
W WP Q SE V +C +CK L + +V NDTG+Y C+Y+
Sbjct: 59 WAWPGAQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKA 118
Query: 107 --ETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCAR 164
E A+ YV+V+D+ PFI + N+ + +PCL SI LNV+L R
Sbjct: 119 RIEGTTAASSYVFVRDFEQPFINKPDT------LLVNRKDAMWVPCLVSIPGLNVTL--R 170
Query: 165 YPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIY 224
PDG + WD ++G + + ++ A + CE D+ + S ++V + G +Y
Sbjct: 171 SQSSVLWPDGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELY 230
Query: 225 DVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSE 284
D+ L P +EL VGEKLVLNCT E N G+ F+W+YP + + K V Q+ +E
Sbjct: 231 DIQLLPRKSLELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTE 290
Query: 285 MKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATV 344
+ S LTI V++ D G Y C A++G+ + ST V VHE PF++ ++EAT
Sbjct: 291 LS---SILTIHNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATA 347
Query: 345 G-ERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNP 403
G E V++P K YPPPE +WYK+G L H+ H L + EV+E TG YT+ L N
Sbjct: 348 GDELVKLPVKLAAYPPPEFQWYKDGKALSGRHS---PHALVLKEVTEASTGTYTLALWNS 404
Query: 404 ISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLE 463
+ +++ + LVV VPPQI EK SP Y + Q LTCT Y +P P I W+W+
Sbjct: 405 AAGLRRNISLELVVNVPPQIHEKEASSP-SIYSRHSRQALTCTAYGVPLPLSIQWHWRPW 463
Query: 464 EECANEPSQAVSVTNPYP----CEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVI 519
C +++ C +WR+V N IE +EGKNKTVS LVI
Sbjct: 464 TPCKMFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVI 523
Query: 520 QAANVSALYKCEAVNKVGRGERVISFHVTRGPE---ITLQPDMQPTEQESVSLWCTADRS 576
Q ANVSA+YKC NKVG+ ER+I F+VT P+ I +P + E + V L C AD
Sbjct: 524 QNANVSAMYKCVVSNKVGQDERLIYFYVTTIPDGFTIESKPSEELLEGQPVLLSCQADSY 583
Query: 577 TFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDI--------LIME 628
+E+L WY+L L G CKN+ L AT + S ++ L +
Sbjct: 584 KYEHLRWYRLNLSTLHDAHGNPLLLDCKNVH----LFATPLAASLEEVAPGARHATLSLS 639
Query: 629 LKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSC 688
+ + + +G YVC QDR++ +HC + L+V AP +T NL + ++ +S+E+ C
Sbjct: 640 IPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQC 699
Query: 689 TASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKV 748
+G P I+W+KD L E SG+ L D N+ L+I+RVR+ED G Y C C+ GC
Sbjct: 700 LVAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNS 759
Query: 749 EAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDP 808
A +EG+++K ++EI+ILVGT VIA+FFW+LL++I ++R ++KTGYLSI+MDP
Sbjct: 760 SASVAVEGSEDKGSMEIVILVGTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDP 819
Query: 809 DELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVK 868
E+PL+E CE L YDAS+WEFPR+RL LG+ LG GAFG+V+EA AFGI K ++C TVAVK
Sbjct: 820 GEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVK 879
Query: 869 MLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYL 928
MLKEGAT SEHRALMSELKILIHIG+HLNVVNLLGACTKP GPLMVIVEFCK+GNLS +L
Sbjct: 880 MLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFL 939
Query: 929 RSKRNEFVPYKTKGARFR-QGKDYVGAIPVDLKR--RLDSITSSQSSASSGFVEEKSLSD 985
R+KR+ F P K R + + V +D +R D + ++ S + G S
Sbjct: 940 RAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRAS--- 996
Query: 986 VEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKIC 1045
++ EDL+ LT+E L+CYSFQVA+GMEFLASRKCIHRDLAARNILLSE +VVKIC
Sbjct: 997 --PDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKIC 1054
Query: 1046 DFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASP 1105
DFGLARDIYKDPDYVRKG ARLPLKWMAPE+IFD+VYT QSDVWSFGVLLWEIFSLGASP
Sbjct: 1055 DFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASP 1114
Query: 1106 YPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQ 1165
YPGV+I+EEFC+RL++GTRMRAP+ TP + + ML+CW G+P RP FSELVE LG+LLQ
Sbjct: 1115 YPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQ 1174
Query: 1166 ANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDP--------KFHYDNT 1217
Q+ ++ + P S + S EE S + T + + + P Y N
Sbjct: 1175 GRGLQEEEEVCMAPRS-SQSSEEGSFSQVSTMALHIAQADAEDSPPSLQRHSLAARYYNW 1233
Query: 1218 AGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTK 1277
L +KTFE+ P+ P DNQTDSGMVLASEE + +E R +
Sbjct: 1234 VSFPGCLARGAETRGSSRMKTFEEFPM-TPTTYKGSVDNQTDSGMVLASEEFEQIESRHR 1292
Query: 1278 LSPSF 1282
F
Sbjct: 1293 QESGF 1297
>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [Homo
sapiens]
Length = 1338
Score = 1039 bits (2687), Expect = 0.0
Identities = 603/1342 (44%), Positives = 819/1342 (61%), Gaps = 57/1342 (4%)
Query: 6 LLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPN 65
+L AL C+ +S G L P LS++ ++A TL + CRG+ W P
Sbjct: 9 VLLCALLSCLLLTGSSSGS---KLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPE 65
Query: 66 NQSGSEQRVEVTECSDGL----FCKTLTIPKVIGNDTGAYKCFY------RETDLASVIY 115
S +R+ +T+ + G FC TLT+ N TG Y C Y ++ + S IY
Sbjct: 66 MVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIY 125
Query: 116 VYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGN 175
+++ D PF+ S+ ++++TE + +VIPC + N+ V+L ++P +PDG
Sbjct: 126 IFISDTGRPFVEMYSEIPEIIHMTEGRE--LVIPCRVTSPNITVTL-KKFPLDTLIPDGK 182
Query: 176 RISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIE 235
RI WDS+KGF I + G++ CEA +N Y++ Y+ I DV +S ++
Sbjct: 183 RIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKT-NYLTHRQTNTIIDVQISTPRPVK 241
Query: 236 LSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTID 295
L G LVLNCTA T LN + W YP K++ + R QS S F S LTID
Sbjct: 242 LLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRI--DQSNSHANIFYSVLTID 299
Query: 296 GVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGER-VRIPAKY 354
+ D+GLYTC SG K +T V +++K F+ + ++E G+R R+ K
Sbjct: 300 KMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKV 359
Query: 355 LGYPPPEIKWYKNGIPL--ESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHV 412
+P PE+ W K+G+P +S + G+ L I +V+E D GNYT++L+ S ++
Sbjct: 360 KAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLT 419
Query: 413 VSLVVYVPPQIGEKSLISPVDS--YQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEP 470
+L+V V PQI EK++ S D Y G+ Q LTCT Y IP P I W+W C +
Sbjct: 420 ATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPT-IKWFWH---PCNHNH 475
Query: 471 SQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKC 530
S+A E + D GN+IE + A+IEGKNK STLV+ + +S +Y C
Sbjct: 476 SEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYIC 535
Query: 531 EAVNKVGRGERVISFHVTRGPE-ITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQ 589
A NKVG R ISF++T P + + PTE E + L CT ++ + ++TW L
Sbjct: 536 IASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRT- 594
Query: 590 PLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKT 649
++ + + K K+ T + T ++ IM N SLQD G Y C A++ T
Sbjct: 595 ---VNNRTMHYSISKQ-----KMAITKEHSITLNLTIM---NVSLQDSGTYACRARNVYT 643
Query: 650 KKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVE 709
+ +++T+ ++ AP + NL + T +I S + C A+G P PQI WFK+N + +
Sbjct: 644 GEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQ 703
Query: 710 DSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILV 769
+ GI+L G+ L I RV +EDEG+Y C+A + G + A+ ++G +K+NLE+I L
Sbjct: 704 EPGIILGPGSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNLELITLT 763
Query: 770 GTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEF 829
T V A FWLLL + +R +KR++ E+KT YLSI+MDPDE+PLDE CERLPYDASKWEF
Sbjct: 764 CTCVAATLFWLLLTLFIRKMKRSSS-EIKTDYLSIIMDPDEVPLDEQCERLPYDASKWEF 822
Query: 830 PRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKIL 889
R+RLKLGK LGRGAFG+V++A AFGI K+ TCRTVAVKMLKEGAT SE++ALM+ELKIL
Sbjct: 823 ARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKIL 882
Query: 890 IHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGK 949
HIGHHLNVVNLLGACTK GGPLMVIVE+CK+GNLS YL+SKR+ F K K
Sbjct: 883 THIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKK 942
Query: 950 DYVG-AIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICY 1008
+ + + K RLDS+TSS+S ASSGF E+KSLSDVEEEE + YK+ +T+E LI Y
Sbjct: 943 EKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISY 1002
Query: 1009 SFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLP 1068
SFQVA+GMEFL+SRKCIHRDLAARNILLSE NVVKICDFGLARDIYK+PDYVRKGD RLP
Sbjct: 1003 SFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLP 1062
Query: 1069 LKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAP 1128
LKWMAPE+IFD++Y+ +SDVWS+GVLLWEIFSLG SPYPGV++DE+FC RL+EG RMRAP
Sbjct: 1063 LKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAP 1122
Query: 1129 DYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEE 1188
+Y+TPE+YQ MLDCWH +P +RP F+ELVE LG+LLQAN QQDGKDYI PI+ L+
Sbjct: 1123 EYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLLQANVQQDGKDYI--PINAILT--G 1178
Query: 1189 DSGLSLPTSPVS-CMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEP 1247
+SG + T S +E + PKF+ ++ + +Y+ K S +KTFE++ P
Sbjct: 1179 NSGFTYSTPAFSEDFFKESISAPKFNSGSSDDV-RYVNAFKFMSLE-RIKTFEEL---LP 1233
Query: 1248 EVKVIPDDNQTDSGMVLASEELKTL---EDRTKLSPSFGGMVPSKSRESVASEGSNQTSG 1304
+ DD Q DS +LAS LK + + K S V SKS+ES S+ S +
Sbjct: 1234 NATSMFDDYQGDSSTLLASPMLKRFTWTDSKPKASLKIDLRVTSKSKESGLSDVSRPSFC 1293
Query: 1305 YQS-GYHSDDTDTTVYSSEEAE 1325
+ S G+ S+ Y E E
Sbjct: 1294 HSSCGHVSEGKRRFTYDHAELE 1315
>gi|229892300 fms-related tyrosine kinase 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 366 bits (940), Expect = e-101
Identities = 240/721 (33%), Positives = 368/721 (51%), Gaps = 41/721 (5%)
Query: 6 LLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPN 65
+L AL C+ +S G L P LS++ ++A TL + CRG+ W P
Sbjct: 9 VLLCALLSCLLLTGSSSGS---KLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPE 65
Query: 66 NQSGSEQRVEVTECSDGL----FCKTLTIPKVIGNDTGAYKCFY------RETDLASVIY 115
S +R+ +T+ + G FC TLT+ N TG Y C Y ++ + S IY
Sbjct: 66 MVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIY 125
Query: 116 VYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGN 175
+++ D PF+ S+ ++++TE + +VIPC + N+ V+L ++P +PDG
Sbjct: 126 IFISDTGRPFVEMYSEIPEIIHMTEGRE--LVIPCRVTSPNITVTL-KKFPLDTLIPDGK 182
Query: 176 RISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIE 235
RI WDS+KGF I + G++ CEA +N Y++ Y+ I DV +S ++
Sbjct: 183 RIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKT-NYLTHRQTNTIIDVQISTPRPVK 241
Query: 236 LSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTID 295
L G LVLNCTA T LN + W YP K++ + R QS S F S LTID
Sbjct: 242 LLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRI--DQSNSHANIFYSVLTID 299
Query: 296 GVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGER-VRIPAKY 354
+ D+GLYTC SG K +T V +++K F+ + ++E G+R R+ K
Sbjct: 300 KMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKV 359
Query: 355 LGYPPPEIKWYKNGIPL--ESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHV 412
+P PE+ W K+G+P +S + G+ L I +V+E D GNYT++L+ S ++
Sbjct: 360 KAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLT 419
Query: 413 VSLVVYVPPQIGEKSLISPVDS--YQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEP 470
+L+V V PQI EK++ S D Y G+ Q LTCT Y IP P I W+W C +
Sbjct: 420 ATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPT-IKWFWH---PCNHNH 475
Query: 471 SQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKC 530
S+A E + D GN+IE + A+IEGKNK STLV+ + +S +Y C
Sbjct: 476 SEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYIC 535
Query: 531 EAVNKVGRGERVISFHVTRGPE-ITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQ 589
A NKVG R ISF++T P + + PTE E + L CT ++ + ++TW L
Sbjct: 536 IASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRT- 594
Query: 590 PLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKT 649
++ + + K K+ T + T ++ IM N SLQD G Y C A++ T
Sbjct: 595 ---VNNRTMHYSISKQ-----KMAITKEHSITLNLTIM---NVSLQDSGTYACRARNVYT 643
Query: 650 KKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVE 709
+ +++T+ ++ AP + NL + T +I S + C A+G P PQI WFK+N + +
Sbjct: 644 GEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQ 703
Query: 710 D 710
+
Sbjct: 704 E 704
Score = 35.8 bits (81), Expect = 0.29
Identities = 31/123 (25%), Positives = 54/123 (43%), Gaps = 7/123 (5%)
Query: 618 SNSTNDIL--IMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLEN 675
SNS +I ++ + +D+G Y C + + K V + + ++ T+ +
Sbjct: 285 SNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKS--VNTSVHIYDKAFITVKHRKQQ 342
Query: 676 --QTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEG 733
+T + S +S P P+++W KD E S L G +L I+ V +ED G
Sbjct: 343 VLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRG-YSLIIKDVTEEDAG 401
Query: 734 LYT 736
YT
Sbjct: 402 NYT 404
Score = 34.7 bits (78), Expect = 0.64
Identities = 51/215 (23%), Positives = 79/215 (36%), Gaps = 43/215 (20%)
Query: 557 PDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNA-- 614
P + P + L CTA + W+ P + E C N + + L+A
Sbjct: 441 PALYPLGSRQI-LTCTAYGIPQPTIKWFW---HPCNHNHSEARCDFCSNNEESFILDADS 496
Query: 615 ---TMFSNSTNDILIMELKN--------ASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLE 663
+ T + I+E KN A + G Y+C+A + K V R ++
Sbjct: 497 NMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASN----KVGTVGRNISFYI 552
Query: 664 RVAPT-ITGNLENQTTSIGESIEVSCTASGNPPPQIMWF---------------KDNETL 707
P NLE T GE +++SCT + + W K +
Sbjct: 553 TDVPNGFHVNLEKMPTE-GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAI 611
Query: 708 VEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSV 742
++ I L NLTI V +D G Y C+A +V
Sbjct: 612 TKEHSITL-----NLTIMNVSLQDSGTYACRARNV 641
>gi|5453870 platelet-derived growth factor receptor alpha precursor
[Homo sapiens]
Length = 1089
Score = 366 bits (939), Expect = e-101
Identities = 293/992 (29%), Positives = 444/992 (44%), Gaps = 175/992 (17%)
Query: 257 DFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTK 316
+ +W+YP S+ + + R+ + SG F++ L + + + GLYTC + T+
Sbjct: 54 EVSWQYPMSEEESSDVEIRNEENNSGL----FVTVLEVSSASAAHTGLYTCYYNH-TQTE 108
Query: 317 KNST-------FVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGI 369
+N +V + FV G + LV + IP + P G+
Sbjct: 109 ENELEGRHIYIYVPDPDVAFVPLGM-TDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGV 167
Query: 370 PLESNHTIKAGHVLTIMEVSERDTGNYTV--ILTNPISKEKQSHVVSLVVYVPPQIGEKS 427
+ +++ + G G +TV + K K+ + VY E
Sbjct: 168 -VPASYDSRQGF-----------NGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELD 215
Query: 428 LISPV--DSYQYGTTQTLTCTVYAIPPPHHIHWYW----------QLEE---------EC 466
L Y+ G T +TC V+ + W + LEE
Sbjct: 216 LEMEALKTVYKSGETIVVTCAVFNNEVVD-LQWTYPGEVKGKGITMLEEIKVPSIKLVYT 274
Query: 467 ANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSA 526
P V + Y C ++ + + K+ ++ ++ IE K T S L
Sbjct: 275 LTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIK-PTFSQL--------- 324
Query: 527 LYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKL 586
EAVN V+ P I+ W + + ENLT
Sbjct: 325 ----EAVNLHEVKHFVVEVRAYPPPRIS---------------WLKNNLTLIENLT---- 361
Query: 587 GPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQD 646
E+ T V K + ++ ++L A +D G Y +AQ+
Sbjct: 362 ----------EITTDVEKIQEIRYRSK-------------LKLIRAKEEDSGHYTIVAQN 398
Query: 647 RKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWF--KDN 704
K + +L +V +I +++ S G V CTA G P P I W KD
Sbjct: 399 EDAVKSYT----FELLTQVPSSILDLVDDHHGSTGGQT-VRCTAEGTPLPDIEWMICKDI 453
Query: 705 ETLVEDSGIVLKDGNRNLTIRRVRKED----EGLYT-----------CQACSVLGCAKVE 749
+ ++ + N + I + D EG T C A ++LG E
Sbjct: 454 KKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRE 513
Query: 750 AFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVK-----RANGGELKTGYLSI 804
+ + + + +LV ++ + +L+VI + + R G+ I
Sbjct: 514 LKLVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYI 573
Query: 805 VMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRT 864
+DP +LP D S+WEFPRD L LG+ LG GAFG+V+E A+G+ ++
Sbjct: 574 YVDPMQLPYD----------SRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMK 623
Query: 865 VAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNL 924
VAVKMLK A SE +ALMSELKI+ H+G HLN+VNLLGACTK GP+ +I E+C +G+L
Sbjct: 624 VAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTK-SGPIYIITEYCFYGDL 682
Query: 925 STYLRSKRNEFVPYKTKGAR----------------------FRQGKDYVGAIPVDLKRR 962
YL R+ F+ + + + F DY+ D +
Sbjct: 683 VNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQY 742
Query: 963 LDSITSSQSSASSGF----------VEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQV 1012
+ + + S S ++KS+ D E + D + LTL L+ +++QV
Sbjct: 743 VPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQV 802
Query: 1013 AKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWM 1072
A+GMEFLAS+ C+HRDLAARN+LL++ +VKICDFGLARDI D +YV KG LP+KWM
Sbjct: 803 ARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWM 862
Query: 1073 APETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTT 1132
APE+IFD +YT SDVWS+G+LLWEIFSLG +PYPG+ +D F ++K G RM PD+ T
Sbjct: 863 APESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHAT 922
Query: 1133 PEMYQTMLDCWHGEPSQRPTFSELVEHLGNLL 1164
E+Y+ M+ CW+ EP +RP+F L E + NLL
Sbjct: 923 SEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
Score = 128 bits (322), Expect = 3e-29
Identities = 118/480 (24%), Positives = 198/480 (41%), Gaps = 66/480 (13%)
Query: 29 LDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWP-NNQSGSEQRVEVTECSDGLFCKT 87
L LP + ++ ++ N++ + C G+ ++ W +P + + S+ + E + GLF
Sbjct: 25 LSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTV 84
Query: 88 LTIPKVIGNDTGAYKCFYRETDLASV------IYVYVQDYRSPFIASVSDQHGVVYITEN 141
L + TG Y C+Y T IY+YV D F+ + V+ ++
Sbjct: 85 LEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDD 144
Query: 142 KNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCE 201
+ +IPC + V+L + + VP S+DS++GF ++ + G CE
Sbjct: 145 ---SAIIPCRTTDPETPVTL---HNSEGVVP----ASYDSRQGFN-GTFTV---GPYICE 190
Query: 202 AKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSV-------GEKLVLNCTARTELNV 254
A + + +Q+I + +Y + + +E+ GE +V+ C N
Sbjct: 191 ATVKGKKFQTIPF-------NVYALKATSELDLEMEALKTVYKSGETIVVTCAVFN--NE 241
Query: 255 GIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLM 314
+D W YP + ++K S K + TLT+ T D G Y CAA
Sbjct: 242 VVDLQWTYPGEVKGKGITMLEEIKVPS----IKLVYTLTVPEATVKDSGDYECAARQATR 297
Query: 315 TKKN--STFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLE 372
K + VHEK F+ L + E + YPPP I W KN + L
Sbjct: 298 EVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLI 357
Query: 373 SNHT-----------IKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPP 421
N T I+ L ++ E D+G+YT++ N +S+ L+ VP
Sbjct: 358 ENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQN--EDAVKSYTFELLTQVP- 414
Query: 422 QIGEKSLISPVDSYQYGTT--QTLTCTVYAIPPPHHIHWYWQLE-EECANEPSQAVSVTN 478
S++ VD + +G+T QT+ CT P P I W + ++C NE S + N
Sbjct: 415 ----SSILDLVDDH-HGSTGGQTVRCTAEGTPLP-DIEWMICKDIKKCNNETSWTILANN 468
>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 2 precursor [Homo sapiens]
Length = 972
Score = 347 bits (889), Expect = 6e-95
Identities = 207/520 (39%), Positives = 291/520 (55%), Gaps = 74/520 (14%)
Query: 686 VSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNL--------------TIRRVRKED 731
+ C A+G P P I W+ T S VL + L +I +
Sbjct: 426 LQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKH 485
Query: 732 EGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIIL----- 786
G C+A + +G F + L +L+G ++A ++++I+
Sbjct: 486 NGTVECKAYNDVGKTSAYFNFAFKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQ 545
Query: 787 --------RTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGK 838
+ V+ NG + +DP +LP D KWEFPR+RL GK
Sbjct: 546 KPMYEVQWKVVEEINGNNY------VYIDPTQLPYDH----------KWEFPRNRLSFGK 589
Query: 839 PLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNV 898
LG GAFG+V+EA A+G+ K+ TVAVKMLK A +E ALMSELK+L ++G+H+N+
Sbjct: 590 TLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNI 649
Query: 899 VNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVD 958
VNLLGACT GGP +VI E+C +G+L +LR KR+ F+ K + D+ A
Sbjct: 650 VNLLGACTI-GGPTLVITEYCCYGDLLNFLRRKRDSFICSKQE--------DHAEAALY- 699
Query: 959 LKRRLDSITSSQSSASSGFVEEKSL------------------SDVEEEEAPEDLYKDFL 1000
K L S SS S +++ +++ K S +E + P + D L
Sbjct: 700 -KNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDEL 758
Query: 1001 TL--EHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPD 1058
L E L+ +S+QVAKGM FLAS+ CIHRDLAARNILL+ + KICDFGLARDI D +
Sbjct: 759 ALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSN 818
Query: 1059 YVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRR 1118
YV KG+ARLP+KWMAPE+IF+ VYT +SDVWS+G+ LWE+FSLG+SPYPG+ +D +F +
Sbjct: 819 YVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKM 878
Query: 1119 LKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVE 1158
+KEG RM +P++ EMY M CW +P +RPTF ++V+
Sbjct: 879 IKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 918
Score = 66.6 bits (161), Expect = 2e-10
Identities = 101/483 (20%), Positives = 191/483 (39%), Gaps = 63/483 (13%)
Query: 6 LLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWP- 64
L + L L V+T ++ + P + K L ++ +++ C + W +
Sbjct: 11 LCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEI 70
Query: 65 -NNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRS 123
+ + ++Q +TE K +TG Y C + L++ IYV+V+D
Sbjct: 71 LDETNENKQNEWITE-------------KAEATNTGKYTCTNKH-GLSNSIYVFVRDPAK 116
Query: 124 PFIASVSDQHGVVYITENKNKTVVIPCLG-SISNLNVSLCARYP---EKRFVPDGNRISW 179
F+ S +Y E+ + V P ++N ++ C P + RF+PD
Sbjct: 117 LFLVDRS-----LYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPD------ 165
Query: 180 DSKKGFTIPSYMISYAGM-VFCEAKINDESYQSIMYIVVV-VGYRIYDVVLSPSHGIELS 237
K G I S +Y + + C +S S +I+ V ++ VV L
Sbjct: 166 -PKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLR 224
Query: 238 VGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGV 297
GE+ + CT + +++ + W+ +S+ KL + G + +TLTI
Sbjct: 225 EGEEFTVTCTIK-DVSSSVYSTWKRENSQ---TKLQEKYNSWHHGDFNYERQATLTISSA 280
Query: 298 TRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGY 357
+D G++ C A++ + +T + V +K F+ + + V GE V + +Y +
Sbjct: 281 RVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAF 340
Query: 358 PPPE-IKW----------YKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISK 406
P PE +W +++ E+ I+ L + + + G YT +++N S
Sbjct: 341 PKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSN--SD 398
Query: 407 EKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYW--QLEE 464
+ ++ V P+I +Y L C P P I WY+ E+
Sbjct: 399 VNAAIAFNVYVNTKPEI---------LTYDRLVNGMLQCVAAGFPEP-TIDWYFCPGTEQ 448
Query: 465 ECA 467
C+
Sbjct: 449 RCS 451
>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 1 precursor [Homo sapiens]
Length = 976
Score = 346 bits (888), Expect = 8e-95
Identities = 208/524 (39%), Positives = 294/524 (56%), Gaps = 78/524 (14%)
Query: 686 VSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNL--------------TIRRVRKED 731
+ C A+G P P I W+ T S VL + L +I +
Sbjct: 426 LQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKH 485
Query: 732 EGLYTCQACSVLGCAKVEAFFIIEGAQEKT----NLEIIILVGTAVIAMFFWLLLVIIL- 786
G C+A + +G F +G ++ L +L+G ++A ++++I+
Sbjct: 486 NGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTY 545
Query: 787 ------------RTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRL 834
+ V+ NG + +DP +LP D KWEFPR+RL
Sbjct: 546 KYLQKPMYEVQWKVVEEINGNNY------VYIDPTQLPYDH----------KWEFPRNRL 589
Query: 835 KLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGH 894
GK LG GAFG+V+EA A+G+ K+ TVAVKMLK A +E ALMSELK+L ++G+
Sbjct: 590 SFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGN 649
Query: 895 HLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGA 954
H+N+VNLLGACT GGP +VI E+C +G+L +LR KR+ F+ K + D+ A
Sbjct: 650 HMNIVNLLGACTI-GGPTLVITEYCCYGDLLNFLRRKRDSFICSKQE--------DHAEA 700
Query: 955 IPVDLKRRLDSITSSQSSASSGFVEEKSL------------------SDVEEEEAPEDLY 996
K L S SS S +++ +++ K S +E + P +
Sbjct: 701 ALY--KNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIME 758
Query: 997 KDFLTL--EHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIY 1054
D L L E L+ +S+QVAKGM FLAS+ CIHRDLAARNILL+ + KICDFGLARDI
Sbjct: 759 DDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIK 818
Query: 1055 KDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEE 1114
D +YV KG+ARLP+KWMAPE+IF+ VYT +SDVWS+G+ LWE+FSLG+SPYPG+ +D +
Sbjct: 819 NDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSK 878
Query: 1115 FCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVE 1158
F + +KEG RM +P++ EMY M CW +P +RPTF ++V+
Sbjct: 879 FYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 922
Score = 66.6 bits (161), Expect = 2e-10
Identities = 101/483 (20%), Positives = 191/483 (39%), Gaps = 63/483 (13%)
Query: 6 LLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWP- 64
L + L L V+T ++ + P + K L ++ +++ C + W +
Sbjct: 11 LCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEI 70
Query: 65 -NNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRS 123
+ + ++Q +TE K +TG Y C + L++ IYV+V+D
Sbjct: 71 LDETNENKQNEWITE-------------KAEATNTGKYTCTNKH-GLSNSIYVFVRDPAK 116
Query: 124 PFIASVSDQHGVVYITENKNKTVVIPCLG-SISNLNVSLCARYP---EKRFVPDGNRISW 179
F+ S +Y E+ + V P ++N ++ C P + RF+PD
Sbjct: 117 LFLVDRS-----LYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPD------ 165
Query: 180 DSKKGFTIPSYMISYAGM-VFCEAKINDESYQSIMYIVVV-VGYRIYDVVLSPSHGIELS 237
K G I S +Y + + C +S S +I+ V ++ VV L
Sbjct: 166 -PKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLR 224
Query: 238 VGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGV 297
GE+ + CT + +++ + W+ +S+ KL + G + +TLTI
Sbjct: 225 EGEEFTVTCTIK-DVSSSVYSTWKRENSQ---TKLQEKYNSWHHGDFNYERQATLTISSA 280
Query: 298 TRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGY 357
+D G++ C A++ + +T + V +K F+ + + V GE V + +Y +
Sbjct: 281 RVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAF 340
Query: 358 PPPE-IKW----------YKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISK 406
P PE +W +++ E+ I+ L + + + G YT +++N S
Sbjct: 341 PKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSN--SD 398
Query: 407 EKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYW--QLEE 464
+ ++ V P+I +Y L C P P I WY+ E+
Sbjct: 399 VNAAIAFNVYVNTKPEI---------LTYDRLVNGMLQCVAAGFPEP-TIDWYFCPGTEQ 448
Query: 465 ECA 467
C+
Sbjct: 449 RCS 451
>gi|27262659 colony stimulating factor 1 receptor precursor [Homo
sapiens]
Length = 972
Score = 340 bits (871), Expect = 7e-93
Identities = 225/581 (38%), Positives = 315/581 (54%), Gaps = 63/581 (10%)
Query: 678 TSIGESIEVSCTASGNPPPQIMWFK-DNETLVEDSGIVLK------------DGNRNLTI 724
T I S + C ASG P P + W + T D VL+ + +T+
Sbjct: 409 TFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTV 468
Query: 725 RRVRK----EDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEII---ILVGTAVIAMF 777
+ + E Y C+A + +G I GA E + ++V I
Sbjct: 469 QSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMAL 528
Query: 778 FWLLLVIILRTVKRANGGELK-------TGYLSIVMDPDELPLDEHCERLPYDASKWEFP 830
LLL+++L K+ +++ G +DP +LP +E KWEFP
Sbjct: 529 LLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNE----------KWEFP 578
Query: 831 RDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILI 890
R+ L+ GK LG GAFG+V+EA AFG+ K VAVKMLK A E ALMSELKI+
Sbjct: 579 RNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMS 638
Query: 891 HIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFV-PYKTKGARFRQGK 949
H+G H N+VNLLGACT GGP++VI E+C +G+L +LR K + P + G G
Sbjct: 639 HLGQHENIVNLLGACTH-GGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGV 697
Query: 950 DYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPE-DLYKDF---LTLEHL 1005
DY R DS SSQ + +VE + +S + E DL K+ L L L
Sbjct: 698 DYKNIHLEKKYVRRDSGFSSQGVDT--YVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDL 755
Query: 1006 ICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDA 1065
+ +S QVA+GM FLAS+ CIHRD+AARN+LL+ +V KI DFGLARDI D +Y+ KG+A
Sbjct: 756 LHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNA 815
Query: 1066 RLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRM 1125
RLP+KWMAPE+IFD VYT+QSDVWS+G+LLWEIFSLG +PYPG+ ++ +F + +K+G +M
Sbjct: 816 RLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQM 875
Query: 1126 RAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQD--GKDYIVLPI--- 1180
P + +Y M CW EP+ RPTF ++ + LQ AQ+D +DY LP
Sbjct: 876 AQPAFAPKNIYSIMQACWALEPTHRPTFQQIC----SFLQEQAQEDRRERDYTNLPSSSR 931
Query: 1181 -----SETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDN 1216
S + +EE+S + ++C E+ ++ P +N
Sbjct: 932 SGGSGSSSSELEEESS----SEHLTCCEQGDIAQPLLQPNN 968
Score = 72.4 bits (176), Expect = 3e-12
Identities = 126/553 (22%), Positives = 212/553 (38%), Gaps = 85/553 (15%)
Query: 9 VALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQS 68
V L L V T G+P + +P L +K T+ + C G ++W P +
Sbjct: 5 VLLLLLVATAWHGQGIPVIEPSVPEL-------VVKPGATVTLRCVGNGSVEWDGPPSPH 57
Query: 69 GSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDL--ASVIYVYVQDYRSPFI 126
T SDG L+ +TG Y+C L ++ I++YV+D P+
Sbjct: 58 W-------TLYSDGS-SSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPW- 108
Query: 127 ASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFT 186
+V Q VV+ +++ ++PCL + L + R + S+ GFT
Sbjct: 109 -NVLAQEVVVF----EDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFT 163
Query: 187 IPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVV-------LSPSHGIELSVG 239
I + C A + SI + ++ V+ L P+ + + G
Sbjct: 164 IHRAKFIQSQDYQCSALMGGRKVMSIS-----IRLKVQKVIPGPPALTLVPAELVRIR-G 217
Query: 240 EKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTR 299
E + C+A + +D N++ +H + KL + +K L TL +D V
Sbjct: 218 EAAQIVCSASS-----VDVNFDV-FLQHNNTKLAIPQQSDFHNNRYQKVL-TLNLDQVDF 270
Query: 300 SDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPP 359
G Y+C AS+ S F RV E ++ S + E TVGE + + YP
Sbjct: 271 QHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPG 330
Query: 360 PE-IKWYKNG-------IPLESNHTIKAGH----VLTIMEVSERDTGNYTVILTNPISKE 407
+ W G P +N T K + L++ + + G Y+ + NP
Sbjct: 331 LQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNP--GG 388
Query: 408 KQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECA 467
++ L + PP+ +S + ++ G + TL C P P ++ W
Sbjct: 389 WRALTFELTLRYPPE------VSVIWTFING-SGTLLCAASGYPQP-NVTWLQCSGHTDR 440
Query: 468 NEPSQAVSV-TNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSA 526
+ +Q + V +PYP E S E F +K+ V S L ++ +
Sbjct: 441 CDEAQVLQVWDDPYP--EVLSQEPF---HKVTVQ--------------SLLTVETLEHNQ 481
Query: 527 LYKCEAVNKVGRG 539
Y+C A N VG G
Sbjct: 482 TYECRAHNSVGSG 494
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 334 bits (857), Expect = 3e-91
Identities = 239/652 (36%), Positives = 328/652 (50%), Gaps = 142/652 (21%)
Query: 636 DQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIGESIEVSCTASG 692
D+G+Y C+ ++ H QL V+ER P + L N+T ++G ++E C
Sbjct: 133 DKGNYTCIVENEYGSINHTY--QLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYS 190
Query: 693 NPPPQIMWFKDNET--------------LVEDSGIVLKDGNRN-LTIRRVRKEDEGLYTC 737
+P P I W K E +++ +G+ D L +R V ED G YTC
Sbjct: 191 DPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTC 250
Query: 738 QACSVLGCAKVEAFF-IIEGAQEKTN-------LEIIIL-VGTAVIAMFFWLLLVIILR- 787
A + +G + A+ ++E +E+ LEIII G +I+ ++V ++
Sbjct: 251 LAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKS 310
Query: 788 --------------------------TVKRANGGELKTGYLSIVMDPDELP--------- 812
TV + + +G L ++ P L
Sbjct: 311 GTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVL--LVRPSRLSSSGTPMLAG 368
Query: 813 LDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRT--VAVKML 870
+ E+ LP D +WE PRDRL LGKPLG G FGQV+ A+A G+DK R VAVKML
Sbjct: 369 VSEY--ELPEDP-RWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML 425
Query: 871 KEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRS 930
K AT + L+SE++++ IG H N++NLLGACT+ G PL VIVE+ GNL YL+
Sbjct: 426 KSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDG-PLYVIVEYASKGNLREYLQ- 483
Query: 931 KRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEE 990
AR G +Y
Sbjct: 484 ------------ARRPPGLEYC---------------------------------YNPSH 498
Query: 991 APEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLA 1050
PE+ L+ + L+ ++QVA+GME+LAS+KCIHRDLAARN+L++E NV+KI DFGLA
Sbjct: 499 NPEEQ----LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLA 554
Query: 1051 RDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVK 1110
RDI+ Y + + RLP+KWMAPE +FDR+YT QSDVWSFGVLLWEIF+LG SPYPGV
Sbjct: 555 RDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVP 614
Query: 1111 IDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQ 1170
++E F + LKEG RM P T E+Y M DCWH PSQRPTF +LVE L ++ + Q
Sbjct: 615 VEELF-KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 673
Query: 1171 DGKDYIVLPI-----------SETLSMEEDSGLSLPTSPVSCMEEEEVCDPK 1211
+ D + +P+ S T S EDS S P EE C P+
Sbjct: 674 EYLD-LSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLP------EEPCLPR 718
Score = 45.1 bits (105), Expect = 5e-04
Identities = 35/143 (24%), Positives = 58/143 (40%), Gaps = 8/143 (5%)
Query: 328 PFVAFGSGMESLVEAT-VGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHV---- 382
P+ ME + A + V+ G P P ++W KNG + +H I V
Sbjct: 62 PYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYAT 121
Query: 383 --LTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTT 440
+ + V D GNYT I+ N ++ + +V P + ++ + + G+
Sbjct: 122 WSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSN 181
Query: 441 QTLTCTVYAIPPPHHIHWYWQLE 463
C VY+ P P HI W +E
Sbjct: 182 VEFMCKVYSDPQP-HIQWLKHIE 203
Score = 37.4 bits (85), Expect = 0.098
Identities = 36/142 (25%), Positives = 55/142 (38%), Gaps = 24/142 (16%)
Query: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEK----PFVAFGSGMESLVEATVGE 346
++ +D V SD+G YTC + + ++ + V E+ P + +G+ + +G
Sbjct: 123 SIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQ--AGLPANKTVALGS 180
Query: 347 RVRIPAKYLGYPPPEIKWYK----NGIPLES--------------NHTIKAGHVLTIMEV 388
V K P P I+W K NG + N T K VL + V
Sbjct: 181 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 240
Query: 389 SERDTGNYTVILTNPISKEKQS 410
S D G YT + N I S
Sbjct: 241 SFEDAGEYTCLAGNSIGLSHHS 262
Score = 32.7 bits (73), Expect = 2.4
Identities = 15/59 (25%), Positives = 29/59 (49%), Gaps = 3/59 (5%)
Query: 682 ESIEVSCTASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNLTIRRVRKEDEGLYTC 737
++++ C +SG P P + W K+ + D G ++ ++ + V D+G YTC
Sbjct: 81 KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTC 139
Score = 31.2 bits (69), Expect = 7.1
Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 2/59 (3%)
Query: 605 NLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLE 663
NL + L + + ++ ++ L+N S +D G+Y CLA + H LTVLE
Sbjct: 213 NLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSA--WLTVLE 269
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 334 bits (857), Expect = 3e-91
Identities = 239/652 (36%), Positives = 328/652 (50%), Gaps = 142/652 (21%)
Query: 636 DQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIGESIEVSCTASG 692
D+G+Y C+ ++ H QL V+ER P + L N+T ++G ++E C
Sbjct: 135 DKGNYTCIVENEYGSINHTY--QLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYS 192
Query: 693 NPPPQIMWFKDNET--------------LVEDSGIVLKDGNRN-LTIRRVRKEDEGLYTC 737
+P P I W K E +++ +G+ D L +R V ED G YTC
Sbjct: 193 DPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTC 252
Query: 738 QACSVLGCAKVEAFF-IIEGAQEKTN-------LEIIIL-VGTAVIAMFFWLLLVIILR- 787
A + +G + A+ ++E +E+ LEIII G +I+ ++V ++
Sbjct: 253 LAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKS 312
Query: 788 --------------------------TVKRANGGELKTGYLSIVMDPDELP--------- 812
TV + + +G L ++ P L
Sbjct: 313 GTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVL--LVRPSRLSSSGTPMLAG 370
Query: 813 LDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRT--VAVKML 870
+ E+ LP D +WE PRDRL LGKPLG G FGQV+ A+A G+DK R VAVKML
Sbjct: 371 VSEY--ELPEDP-RWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML 427
Query: 871 KEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRS 930
K AT + L+SE++++ IG H N++NLLGACT+ G PL VIVE+ GNL YL+
Sbjct: 428 KSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDG-PLYVIVEYASKGNLREYLQ- 485
Query: 931 KRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEE 990
AR G +Y
Sbjct: 486 ------------ARRPPGLEYC---------------------------------YNPSH 500
Query: 991 APEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLA 1050
PE+ L+ + L+ ++QVA+GME+LAS+KCIHRDLAARN+L++E NV+KI DFGLA
Sbjct: 501 NPEEQ----LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLA 556
Query: 1051 RDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVK 1110
RDI+ Y + + RLP+KWMAPE +FDR+YT QSDVWSFGVLLWEIF+LG SPYPGV
Sbjct: 557 RDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVP 616
Query: 1111 IDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQ 1170
++E F + LKEG RM P T E+Y M DCWH PSQRPTF +LVE L ++ + Q
Sbjct: 617 VEELF-KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 675
Query: 1171 DGKDYIVLPI-----------SETLSMEEDSGLSLPTSPVSCMEEEEVCDPK 1211
+ D + +P+ S T S EDS S P EE C P+
Sbjct: 676 EYLD-LSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLP------EEPCLPR 720
Score = 45.4 bits (106), Expect = 4e-04
Identities = 36/148 (24%), Positives = 60/148 (40%), Gaps = 8/148 (5%)
Query: 323 RVHEKPFVAFGSGMESLVEAT-VGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGH 381
R+ P+ ME + A + V+ G P P ++W KNG + +H I
Sbjct: 59 RMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYK 118
Query: 382 V------LTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSY 435
V + + V D GNYT I+ N ++ + +V P + ++ + +
Sbjct: 119 VRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTV 178
Query: 436 QYGTTQTLTCTVYAIPPPHHIHWYWQLE 463
G+ C VY+ P P HI W +E
Sbjct: 179 ALGSNVEFMCKVYSDPQP-HIQWLKHIE 205
Score = 37.4 bits (85), Expect = 0.098
Identities = 36/142 (25%), Positives = 55/142 (38%), Gaps = 24/142 (16%)
Query: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEK----PFVAFGSGMESLVEATVGE 346
++ +D V SD+G YTC + + ++ + V E+ P + +G+ + +G
Sbjct: 125 SIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQ--AGLPANKTVALGS 182
Query: 347 RVRIPAKYLGYPPPEIKWYK----NGIPLES--------------NHTIKAGHVLTIMEV 388
V K P P I+W K NG + N T K VL + V
Sbjct: 183 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 242
Query: 389 SERDTGNYTVILTNPISKEKQS 410
S D G YT + N I S
Sbjct: 243 SFEDAGEYTCLAGNSIGLSHHS 264
Score = 32.7 bits (73), Expect = 2.4
Identities = 15/59 (25%), Positives = 29/59 (49%), Gaps = 3/59 (5%)
Query: 682 ESIEVSCTASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNLTIRRVRKEDEGLYTC 737
++++ C +SG P P + W K+ + D G ++ ++ + V D+G YTC
Sbjct: 83 KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTC 141
Score = 31.2 bits (69), Expect = 7.1
Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 2/59 (3%)
Query: 605 NLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLE 663
NL + L + + ++ ++ L+N S +D G+Y CLA + H LTVLE
Sbjct: 215 NLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSA--WLTVLE 271
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 334 bits (857), Expect = 3e-91
Identities = 239/652 (36%), Positives = 328/652 (50%), Gaps = 142/652 (21%)
Query: 636 DQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIGESIEVSCTASG 692
D+G+Y C+ ++ H QL V+ER P + L N+T ++G ++E C
Sbjct: 222 DKGNYTCIVENEYGSINHTY--QLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYS 279
Query: 693 NPPPQIMWFKDNET--------------LVEDSGIVLKDGNRN-LTIRRVRKEDEGLYTC 737
+P P I W K E +++ +G+ D L +R V ED G YTC
Sbjct: 280 DPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTC 339
Query: 738 QACSVLGCAKVEAFF-IIEGAQEKTN-------LEIIIL-VGTAVIAMFFWLLLVIILR- 787
A + +G + A+ ++E +E+ LEIII G +I+ ++V ++
Sbjct: 340 LAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKS 399
Query: 788 --------------------------TVKRANGGELKTGYLSIVMDPDELP--------- 812
TV + + +G L ++ P L
Sbjct: 400 GTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVL--LVRPSRLSSSGTPMLAG 457
Query: 813 LDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRT--VAVKML 870
+ E+ LP D +WE PRDRL LGKPLG G FGQV+ A+A G+DK R VAVKML
Sbjct: 458 VSEY--ELPEDP-RWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML 514
Query: 871 KEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRS 930
K AT + L+SE++++ IG H N++NLLGACT+ G PL VIVE+ GNL YL+
Sbjct: 515 KSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDG-PLYVIVEYASKGNLREYLQ- 572
Query: 931 KRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEE 990
AR G +Y
Sbjct: 573 ------------ARRPPGLEYC---------------------------------YNPSH 587
Query: 991 APEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLA 1050
PE+ L+ + L+ ++QVA+GME+LAS+KCIHRDLAARN+L++E NV+KI DFGLA
Sbjct: 588 NPEEQ----LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLA 643
Query: 1051 RDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVK 1110
RDI+ Y + + RLP+KWMAPE +FDR+YT QSDVWSFGVLLWEIF+LG SPYPGV
Sbjct: 644 RDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVP 703
Query: 1111 IDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQ 1170
++E F + LKEG RM P T E+Y M DCWH PSQRPTF +LVE L ++ + Q
Sbjct: 704 VEELF-KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 762
Query: 1171 DGKDYIVLPI-----------SETLSMEEDSGLSLPTSPVSCMEEEEVCDPK 1211
+ D + +P+ S T S EDS S P EE C P+
Sbjct: 763 EYLD-LSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLP------EEPCLPR 807
Score = 45.1 bits (105), Expect = 5e-04
Identities = 35/143 (24%), Positives = 58/143 (40%), Gaps = 8/143 (5%)
Query: 328 PFVAFGSGMESLVEAT-VGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHV---- 382
P+ ME + A + V+ G P P ++W KNG + +H I V
Sbjct: 151 PYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYAT 210
Query: 383 --LTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTT 440
+ + V D GNYT I+ N ++ + +V P + ++ + + G+
Sbjct: 211 WSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSN 270
Query: 441 QTLTCTVYAIPPPHHIHWYWQLE 463
C VY+ P P HI W +E
Sbjct: 271 VEFMCKVYSDPQP-HIQWLKHIE 292
Score = 37.4 bits (85), Expect = 0.098
Identities = 36/142 (25%), Positives = 55/142 (38%), Gaps = 24/142 (16%)
Query: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEK----PFVAFGSGMESLVEATVGE 346
++ +D V SD+G YTC + + ++ + V E+ P + +G+ + +G
Sbjct: 212 SIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQ--AGLPANKTVALGS 269
Query: 347 RVRIPAKYLGYPPPEIKWYK----NGIPLES--------------NHTIKAGHVLTIMEV 388
V K P P I+W K NG + N T K VL + V
Sbjct: 270 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 329
Query: 389 SERDTGNYTVILTNPISKEKQS 410
S D G YT + N I S
Sbjct: 330 SFEDAGEYTCLAGNSIGLSHHS 351
Score = 35.8 bits (81), Expect = 0.29
Identities = 68/329 (20%), Positives = 120/329 (36%), Gaps = 61/329 (18%)
Query: 362 IKWYKNGIPL-ESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVP 420
I W ++G+ L ESN T G + + + D+G Y + ++P + V++ +P
Sbjct: 64 INWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALP 123
Query: 421 PQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYW----QLEEECANEPS----- 471
+ S + T T P+ + YW ++E++ P+
Sbjct: 124 SSEDDDD-DDDSSSEEKETDNT---------KPNPVAPYWTSPEKMEKKLHAVPAAKTVK 173
Query: 472 -QAVSVTNPYPCEEW-RSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAA-NVSALY 528
+ S P P W ++ ++F+ ++I K ++A T S ++ + Y
Sbjct: 174 FKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA-------TWSIIMDSVVPSDKGNY 226
Query: 529 KCEAVNKVGRGERVISFHVT-RGPEITLQPDMQPTEQ-----ESVSLWCTADRSTFENLT 582
C N+ G V R P + P + +V C ++
Sbjct: 227 TCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQ 286
Query: 583 WYK--------LGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASL 634
W K +GP LP +V L T D ++ ++ L+N S
Sbjct: 287 WLKHIEVNGSKIGPDNLP-YVQILKTAGVNTTD--------------KEMEVLHLRNVSF 331
Query: 635 QDQGDYVCLAQDRKTKKRHCVVRQLTVLE 663
+D G+Y CLA + H LTVLE
Sbjct: 332 EDAGEYTCLAGNSIGLSHHSA--WLTVLE 358
Score = 32.7 bits (73), Expect = 2.4
Identities = 15/59 (25%), Positives = 29/59 (49%), Gaps = 3/59 (5%)
Query: 682 ESIEVSCTASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNLTIRRVRKEDEGLYTC 737
++++ C +SG P P + W K+ + D G ++ ++ + V D+G YTC
Sbjct: 170 KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTC 228
>gi|105990522 fibroblast growth factor receptor 1 isoform 1 precursor
[Homo sapiens]
Length = 822
Score = 334 bits (857), Expect = 3e-91
Identities = 239/652 (36%), Positives = 328/652 (50%), Gaps = 142/652 (21%)
Query: 636 DQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIGESIEVSCTASG 692
D+G+Y C+ ++ H QL V+ER P + L N+T ++G ++E C
Sbjct: 224 DKGNYTCIVENEYGSINHTY--QLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYS 281
Query: 693 NPPPQIMWFKDNET--------------LVEDSGIVLKDGNRN-LTIRRVRKEDEGLYTC 737
+P P I W K E +++ +G+ D L +R V ED G YTC
Sbjct: 282 DPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTC 341
Query: 738 QACSVLGCAKVEAFF-IIEGAQEKTN-------LEIIIL-VGTAVIAMFFWLLLVIILR- 787
A + +G + A+ ++E +E+ LEIII G +I+ ++V ++
Sbjct: 342 LAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKS 401
Query: 788 --------------------------TVKRANGGELKTGYLSIVMDPDELP--------- 812
TV + + +G L ++ P L
Sbjct: 402 GTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVL--LVRPSRLSSSGTPMLAG 459
Query: 813 LDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRT--VAVKML 870
+ E+ LP D +WE PRDRL LGKPLG G FGQV+ A+A G+DK R VAVKML
Sbjct: 460 VSEY--ELPEDP-RWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML 516
Query: 871 KEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRS 930
K AT + L+SE++++ IG H N++NLLGACT+ G PL VIVE+ GNL YL+
Sbjct: 517 KSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDG-PLYVIVEYASKGNLREYLQ- 574
Query: 931 KRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEE 990
AR G +Y
Sbjct: 575 ------------ARRPPGLEYC---------------------------------YNPSH 589
Query: 991 APEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLA 1050
PE+ L+ + L+ ++QVA+GME+LAS+KCIHRDLAARN+L++E NV+KI DFGLA
Sbjct: 590 NPEEQ----LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLA 645
Query: 1051 RDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVK 1110
RDI+ Y + + RLP+KWMAPE +FDR+YT QSDVWSFGVLLWEIF+LG SPYPGV
Sbjct: 646 RDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVP 705
Query: 1111 IDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQ 1170
++E F + LKEG RM P T E+Y M DCWH PSQRPTF +LVE L ++ + Q
Sbjct: 706 VEELF-KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 764
Query: 1171 DGKDYIVLPI-----------SETLSMEEDSGLSLPTSPVSCMEEEEVCDPK 1211
+ D + +P+ S T S EDS S P EE C P+
Sbjct: 765 EYLD-LSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLP------EEPCLPR 809
Score = 45.8 bits (107), Expect = 3e-04
Identities = 46/190 (24%), Positives = 75/190 (39%), Gaps = 9/190 (4%)
Query: 281 SGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLV 340
SGS+ F S D + S+ +SS N+ R+ P+ ME +
Sbjct: 107 SGSDTTYF-SVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKL 165
Query: 341 EAT-VGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHV------LTIMEVSERDT 393
A + V+ G P P ++W KNG + +H I V + + V D
Sbjct: 166 HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 225
Query: 394 GNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPP 453
GNYT I+ N ++ + +V P + ++ + + G+ C VY+ P P
Sbjct: 226 GNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQP 285
Query: 454 HHIHWYWQLE 463
HI W +E
Sbjct: 286 -HIQWLKHIE 294
Score = 37.4 bits (85), Expect = 0.098
Identities = 36/142 (25%), Positives = 55/142 (38%), Gaps = 24/142 (16%)
Query: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEK----PFVAFGSGMESLVEATVGE 346
++ +D V SD+G YTC + + ++ + V E+ P + +G+ + +G
Sbjct: 214 SIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQ--AGLPANKTVALGS 271
Query: 347 RVRIPAKYLGYPPPEIKWYK----NGIPLES--------------NHTIKAGHVLTIMEV 388
V K P P I+W K NG + N T K VL + V
Sbjct: 272 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 331
Query: 389 SERDTGNYTVILTNPISKEKQS 410
S D G YT + N I S
Sbjct: 332 SFEDAGEYTCLAGNSIGLSHHS 353
Score = 34.7 bits (78), Expect = 0.64
Identities = 68/329 (20%), Positives = 119/329 (36%), Gaps = 59/329 (17%)
Query: 362 IKWYKNGIPL-ESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVP 420
I W ++G+ L ESN T G + + + D+G Y + ++P + V++ +P
Sbjct: 64 INWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALP 123
Query: 421 PQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYW----QLEEECANEPS----- 471
+ S + T T + P YW ++E++ P+
Sbjct: 124 SSEDDDD-DDDSSSEEKETDNTKPNRMPVAP-------YWTSPEKMEKKLHAVPAAKTVK 175
Query: 472 -QAVSVTNPYPCEEW-RSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAA-NVSALY 528
+ S P P W ++ ++F+ ++I K ++A T S ++ + Y
Sbjct: 176 FKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA-------TWSIIMDSVVPSDKGNY 228
Query: 529 KCEAVNKVGRGERVISFHVT-RGPEITLQPDMQPTEQ-----ESVSLWCTADRSTFENLT 582
C N+ G V R P + P + +V C ++
Sbjct: 229 TCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQ 288
Query: 583 WYK--------LGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASL 634
W K +GP LP +V L T D ++ ++ L+N S
Sbjct: 289 WLKHIEVNGSKIGPDNLP-YVQILKTAGVNTTD--------------KEMEVLHLRNVSF 333
Query: 635 QDQGDYVCLAQDRKTKKRHCVVRQLTVLE 663
+D G+Y CLA + H LTVLE
Sbjct: 334 EDAGEYTCLAGNSIGLSHHSA--WLTVLE 360
Score = 32.7 bits (73), Expect = 2.4
Identities = 15/59 (25%), Positives = 29/59 (49%), Gaps = 3/59 (5%)
Query: 682 ESIEVSCTASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNLTIRRVRKEDEGLYTC 737
++++ C +SG P P + W K+ + D G ++ ++ + V D+G YTC
Sbjct: 172 KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTC 230
>gi|121114304 fms-related tyrosine kinase 3 [Homo sapiens]
Length = 993
Score = 330 bits (847), Expect = 4e-90
Identities = 213/561 (37%), Positives = 297/561 (52%), Gaps = 47/561 (8%)
Query: 676 QTTSIGESIEVSCTASGNPPPQIMWFK-----DNETLVEDSGIVLKDGNRNL-------- 722
Q + + + SC + G P P W K N T G+ + NR +
Sbjct: 440 QVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSS 499
Query: 723 TIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLL 782
T+ L C A + LG + G I V +F +L
Sbjct: 500 TLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLT 559
Query: 783 VIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGR 842
++I K+ E + + + D YD KWEFPR+ L+ GK LG
Sbjct: 560 LLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDL-KWEFPRENLEFGKVLGS 618
Query: 843 GAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLL 902
GAFG+V+ A A+GI KT VAVKMLKE A SE ALMSELK++ +G H N+VNLL
Sbjct: 619 GAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLL 678
Query: 903 GACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQ-------------GK 949
GACT GP+ +I E+C +G+L YLRSKR +F ++T F++
Sbjct: 679 GACTL-SGPIYLIFEYCCYGDLLNYLRSKREKF--HRTWTEIFKEHNFSFYPTFQSHPNS 735
Query: 950 DYVGAIPVDLKRRLDSITSSQSSA--SSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLIC 1007
G+ V + D I+ ++ S +E ++ +EEEE DL + LT E L+C
Sbjct: 736 SMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEE---DL--NVLTFEDLLC 790
Query: 1008 YSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARL 1067
+++QVAKGMEFL + C+HRDLAARN+L++ VVKICDFGLARDI D +YV +G+ARL
Sbjct: 791 FAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARL 850
Query: 1068 PLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRA 1127
P+KWMAPE++F+ +YTI+SDVWS+G+LLWEIFSLG +PYPG+ +D F + ++ G +M
Sbjct: 851 PVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQ 910
Query: 1128 PDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISE----- 1182
P Y T E+Y M CW + +RP+F L LG L A+A++ + +SE
Sbjct: 911 PFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQL-ADAEEAMYQNVDGRVSECPHTY 969
Query: 1183 ----TLSMEEDSGLSLPTSPV 1199
S E D GL P + V
Sbjct: 970 QNRRPFSREMDLGLLSPQAQV 990
Score = 40.0 bits (92), Expect = 0.015
Identities = 49/197 (24%), Positives = 73/197 (37%), Gaps = 41/197 (20%)
Query: 236 LSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLT-- 293
L VGE L + C A +N G WE L N+ L+ + EM + + T
Sbjct: 262 LKVGEPLWIRCKA-VHVNHGFGLTWE----------LENKALEEGNYFEMSTYSTNRTMI 310
Query: 294 ------IDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGER 347
+ V R+D G YTC++S S V + EK F+ + E E E
Sbjct: 311 RILFAFVSSVARNDTGYYTCSSSK---HPSQSALVTIVEKGFINATNSSED-YEIDQYEE 366
Query: 348 VRIPAKYLGYP-------------PPEIKWYKNGIPLES--NHTIKAGHVLTIMEVSERD 392
++ YP P E K NG + NH + G + +E D
Sbjct: 367 FCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIF---HAEND 423
Query: 393 TGNYTVILTNPISKEKQ 409
+T + T I ++ Q
Sbjct: 424 DAQFTKMFTLNIRRKPQ 440
>gi|222144241 fibroblast growth factor receptor 2 isoform 8 precursor
[Homo sapiens]
Length = 704
Score = 329 bits (843), Expect = 1e-89
Identities = 240/642 (37%), Positives = 319/642 (49%), Gaps = 124/642 (19%)
Query: 625 LIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIG 681
LIME S D+G+Y C+ ++ H L V+ER P + L N +T +G
Sbjct: 101 LIMESVVPS--DKGNYTCVVENEYGSINHTY--HLDVVERSPHRPILQAGLPANASTVVG 156
Query: 682 ESIEVSCTASGNPPPQIMWFKD---NETLVEDSGI----VLKDGNRNLT--------IRR 726
+E C + P I W K N + G+ VLK N T IR
Sbjct: 157 GDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRN 216
Query: 727 VRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTN--------LEIIIL-VGTAVIA-M 776
V ED G YTC A + +G + A+ + A + LEI I +G +IA M
Sbjct: 217 VTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACM 276
Query: 777 FFWLLLVIILRTVKRANGGELKTGYLSIVMDP--------------DELPLDEHCERLPY 822
++L + T K+ + + P PL RL
Sbjct: 277 VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLSS 336
Query: 823 DAS----------------KWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCR--T 864
A KWEFPRD+L LGKPLG G FGQV+ A+A GIDK T
Sbjct: 337 TADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVT 396
Query: 865 VAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNL 924
VAVKMLK+ AT + L+SE++++ IG H N++NLLGACT+ G PL VIVE+ GNL
Sbjct: 397 VAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG-PLYVIVEYASKGNL 455
Query: 925 STYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLS 984
YLR++R + Y D+ R
Sbjct: 456 REYLRARRPPGMEYS-----------------YDINR----------------------- 475
Query: 985 DVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKI 1044
V EE+ +T + L+ ++Q+A+GME+LAS+KCIHRDLAARN+L++E NV+KI
Sbjct: 476 -VPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKI 525
Query: 1045 CDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGAS 1104
DFGLARDI Y + + RLP+KWMAPE +FDRVYT QSDVWSFGVL+WEIF+LG S
Sbjct: 526 ADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGS 585
Query: 1105 PYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLL 1164
PYPG+ ++E F + LKEG RM P T E+Y M DCWH PSQRPTF +LVE L +L
Sbjct: 586 PYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 644
Query: 1165 QANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEE 1206
++ L +S+ L E S P + SC ++
Sbjct: 645 TLTTNEE-----YLDLSQPL---EQYSPSYPDTRSSCSSGDD 678
Score = 41.6 bits (96), Expect = 0.005
Identities = 35/124 (28%), Positives = 53/124 (42%), Gaps = 9/124 (7%)
Query: 347 RVRIPAKYLGYPPPEIKWYKNGIPLESNHTI-----KAGHVLTIME-VSERDTGNYTVIL 400
+ R PA G P P ++W KNG + H I + H IME V D GNYT ++
Sbjct: 61 KFRCPAG--GNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV 118
Query: 401 TNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYW 460
N ++ + +V P + ++ + S G C VY+ P HI W
Sbjct: 119 ENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQP-HIQWIK 177
Query: 461 QLEE 464
+E+
Sbjct: 178 HVEK 181
Score = 37.0 bits (84), Expect = 0.13
Identities = 27/112 (24%), Positives = 51/112 (45%), Gaps = 12/112 (10%)
Query: 638 GDYVCL-----AQDRKTKKRHCVVRQLTVLERVAP--TITGNLENQTTSI--GESIEVSC 688
G ++CL A + +V T+ AP T T +E + ++ +++ C
Sbjct: 5 GRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRC 64
Query: 689 TASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNLTIRRVRKEDEGLYTC 737
A GNP P + W K+ + ++ G +++ + +L + V D+G YTC
Sbjct: 65 PAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTC 116
Score = 35.8 bits (81), Expect = 0.29
Identities = 35/136 (25%), Positives = 54/136 (39%), Gaps = 24/136 (17%)
Query: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEK----PFVAFGSGMESLVEATVGE 346
+L ++ V SD+G YTC + + ++ + V E+ P + +G+ + VG
Sbjct: 100 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQ--AGLPANASTVVGG 157
Query: 347 RVRIPAKYLGYPPPEIKWYKN-----------GIPLES-------NHTIKAGHVLTIMEV 388
V K P I+W K+ G+P N T K VL I V
Sbjct: 158 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 217
Query: 389 SERDTGNYTVILTNPI 404
+ D G YT + N I
Sbjct: 218 TFEDAGEYTCLAGNSI 233
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 328 bits (842), Expect = 2e-89
Identities = 224/622 (36%), Positives = 311/622 (50%), Gaps = 117/622 (18%)
Query: 636 DQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIGESIEVSCTASG 692
D+G+Y C+ +++ R L VLER P + L NQT +G +E C
Sbjct: 222 DRGNYTCVVENKFGSIRQTYT--LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYS 279
Query: 693 NPPPQIMWFKDNETLVEDSG-------IVLKDGNRN--------LTIRRVRKEDEGLYTC 737
+ P I W K E G VLK N L++ V ED G YTC
Sbjct: 280 DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTC 339
Query: 738 QACSVLGCAKVEAFFIIEGAQEK---TNLEIIILVGTAVIAMFFWLLLVII-------LR 787
A + +G + A+ ++ A+E+ + + G + F+L ++++ LR
Sbjct: 340 LAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLR 399
Query: 788 TVKRANGGELKTGYLSIVMDPDELPLDEHCE---------------------------RL 820
+ + G +S ++ L+ + L
Sbjct: 400 SPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELEL 459
Query: 821 PYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCR--TVAVKMLKEGATHSE 878
P D KWE R RL LGKPLG G FGQV+ A+A GIDK + TVAVKMLK+ AT +
Sbjct: 460 PADP-KWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKD 518
Query: 879 HRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPY 938
L+SE++++ IG H N++NLLGACT+ GGPL V+VE+ GNL +LR++R
Sbjct: 519 LSDLVSEMEMMKMIGKHKNIINLLGACTQ-GGPLYVLVEYAAKGNLREFLRARRPP---- 573
Query: 939 KTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKD 998
G DY + + PE+
Sbjct: 574 ---------GLDY---------------------------------SFDTCKPPEEQ--- 588
Query: 999 FLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPD 1058
LT + L+ ++QVA+GME+LAS+KCIHRDLAARN+L++E NV+KI DFGLARD++
Sbjct: 589 -LTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDY 647
Query: 1059 YVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRR 1118
Y + + RLP+KWMAPE +FDRVYT QSDVWSFGVLLWEIF+LG SPYPG+ ++E F +
Sbjct: 648 YKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELF-KL 706
Query: 1119 LKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVL 1178
LKEG RM P T ++Y M +CWH PSQRPTF +LVE L +L + + L
Sbjct: 707 LKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDE-----YL 761
Query: 1179 PISETLSMEEDSGLSLPTSPVS 1200
+S G P+S S
Sbjct: 762 DLSAPFEQYSPGGQDTPSSSSS 783
Score = 45.8 bits (107), Expect = 3e-04
Identities = 34/133 (25%), Positives = 53/133 (39%), Gaps = 7/133 (5%)
Query: 337 ESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHT---IKAGH---VLTIMEVSE 390
+ L+ VR G P P I W KNG H IK H L + V
Sbjct: 161 KKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVP 220
Query: 391 RDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAI 450
D GNYT ++ N +Q++ + ++ P + ++ + + G+ C VY+
Sbjct: 221 SDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSD 280
Query: 451 PPPHHIHWYWQLE 463
P HI W +E
Sbjct: 281 AQP-HIQWLKHVE 292
Score = 37.7 bits (86), Expect = 0.075
Identities = 33/135 (24%), Positives = 55/135 (40%), Gaps = 24/135 (17%)
Query: 627 MELKNASLQDQGDYVCLAQDRKTKKRHCVVR-----------------QLTVLERVAP-- 667
+++ NAS +D G Y C + + H VR + T ++ AP
Sbjct: 94 LQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYW 153
Query: 668 TITGNLENQTTSI--GESIEVSCTASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNL 722
T ++ + ++ ++ C A+GNP P I W K+ + GI L+ +L
Sbjct: 154 TRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSL 213
Query: 723 TIRRVRKEDEGLYTC 737
+ V D G YTC
Sbjct: 214 VMESVVPSDRGNYTC 228
Score = 37.0 bits (84), Expect = 0.13
Identities = 20/69 (28%), Positives = 32/69 (46%), Gaps = 3/69 (4%)
Query: 671 GNLENQTTSIGESIEVSCTA-SGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRK 729
G E G+++E+SC G P +W KD LV +++ G + L +
Sbjct: 44 GQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLV--GPQRLQVLNASH 101
Query: 730 EDEGLYTCQ 738
ED G Y+C+
Sbjct: 102 EDSGAYSCR 110
Score = 37.0 bits (84), Expect = 0.13
Identities = 38/154 (24%), Positives = 64/154 (41%), Gaps = 27/154 (17%)
Query: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEK----PFVAFGSGMESLVEATVGE 346
+L ++ V SD+G YTC + + + + + V E+ P + +G+ + A +G
Sbjct: 212 SLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQ--AGLPANQTAVLGS 269
Query: 347 RVRIPAKYLGYPPPEIKWYKN-----------GIPLES-------NHTIKAGHVLTIMEV 388
V K P I+W K+ G P + N T K VL++ V
Sbjct: 270 DVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNV 329
Query: 389 SERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQ 422
+ D G YT + N I SH + +V +P +
Sbjct: 330 TFEDAGEYTCLAGNSIG---FSHHSAWLVVLPAE 360
>gi|229892220 fms-related tyrosine kinase 1 isoform 2 precursor
[Homo sapiens]
Length = 687
Score = 328 bits (841), Expect = 2e-89
Identities = 222/672 (33%), Positives = 339/672 (50%), Gaps = 41/672 (6%)
Query: 6 LLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPN 65
+L AL C+ +S G L P LS++ ++A TL + CRG+ W P
Sbjct: 9 VLLCALLSCLLLTGSSSGS---KLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPE 65
Query: 66 NQSGSEQRVEVTECSDGL----FCKTLTIPKVIGNDTGAYKCFY------RETDLASVIY 115
S +R+ +T+ + G FC TLT+ N TG Y C Y ++ + S IY
Sbjct: 66 MVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIY 125
Query: 116 VYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGN 175
+++ D PF+ S+ ++++TE + +VIPC + N+ V+L ++P +PDG
Sbjct: 126 IFISDTGRPFVEMYSEIPEIIHMTEGRE--LVIPCRVTSPNITVTL-KKFPLDTLIPDGK 182
Query: 176 RISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIE 235
RI WDS+KGF I + G++ CEA +N Y++ Y+ I DV +S ++
Sbjct: 183 RIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKT-NYLTHRQTNTIIDVQISTPRPVK 241
Query: 236 LSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTID 295
L G LVLNCTA T LN + W YP K++ + R QS S F S LTID
Sbjct: 242 LLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRI--DQSNSHANIFYSVLTID 299
Query: 296 GVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGER-VRIPAKY 354
+ D+GLYTC SG K +T V +++K F+ + ++E G+R R+ K
Sbjct: 300 KMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKV 359
Query: 355 LGYPPPEIKWYKNGIPL--ESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHV 412
+P PE+ W K+G+P +S + G+ L I +V+E D GNYT++L+ S ++
Sbjct: 360 KAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLT 419
Query: 413 VSLVVYVPPQIGEKSLISPVDS--YQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEP 470
+L+V V PQI EK++ S D Y G+ Q LTCT Y IP P I W+W C +
Sbjct: 420 ATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPT-IKWFWH---PCNHNH 475
Query: 471 SQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKC 530
S+A E + D GN+IE + A+IEGKNK STLV+ + +S +Y C
Sbjct: 476 SEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYIC 535
Query: 531 EAVNKVGRGERVISFHVTRGPE-ITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQ 589
A NKVG R ISF++T P + + PTE E + L CT ++ + ++TW L
Sbjct: 536 IASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILL--- 592
Query: 590 PLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKT 649
++ + + K K+ T + T ++ IM N SLQD G Y C A++ T
Sbjct: 593 -RTVNNRTMHYSISKQ-----KMAITKEHSITLNLTIM---NVSLQDSGTYACRARNVYT 643
Query: 650 KKRHCVVRQLTV 661
+ +++T+
Sbjct: 644 GEEILQKKEITI 655
Score = 35.8 bits (81), Expect = 0.29
Identities = 31/123 (25%), Positives = 54/123 (43%), Gaps = 7/123 (5%)
Query: 618 SNSTNDIL--IMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLEN 675
SNS +I ++ + +D+G Y C + + K V + + ++ T+ +
Sbjct: 285 SNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKS--VNTSVHIYDKAFITVKHRKQQ 342
Query: 676 --QTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEG 733
+T + S +S P P+++W KD E S L G +L I+ V +ED G
Sbjct: 343 VLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRG-YSLIIKDVTEEDAG 401
Query: 734 LYT 736
YT
Sbjct: 402 NYT 404
Score = 34.7 bits (78), Expect = 0.64
Identities = 51/215 (23%), Positives = 79/215 (36%), Gaps = 43/215 (20%)
Query: 557 PDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNA-- 614
P + P + L CTA + W+ P + E C N + + L+A
Sbjct: 441 PALYPLGSRQI-LTCTAYGIPQPTIKWFW---HPCNHNHSEARCDFCSNNEESFILDADS 496
Query: 615 ---TMFSNSTNDILIMELKN--------ASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLE 663
+ T + I+E KN A + G Y+C+A + K V R ++
Sbjct: 497 NMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASN----KVGTVGRNISFYI 552
Query: 664 RVAPT-ITGNLENQTTSIGESIEVSCTASGNPPPQIMWF---------------KDNETL 707
P NLE T GE +++SCT + + W K +
Sbjct: 553 TDVPNGFHVNLEKMPTE-GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAI 611
Query: 708 VEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSV 742
++ I L NLTI V +D G Y C+A +V
Sbjct: 612 TKEHSITL-----NLTIMNVSLQDSGTYACRARNV 641
>gi|222144237 fibroblast growth factor receptor 2 isoform 6 precursor
[Homo sapiens]
Length = 706
Score = 328 bits (841), Expect = 2e-89
Identities = 244/648 (37%), Positives = 322/648 (49%), Gaps = 134/648 (20%)
Query: 625 LIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIG 681
LIME S D+G+Y C+ ++ H L V+ER P + L N +T +G
Sbjct: 101 LIMESVVPS--DKGNYTCVVENEYGSINHTY--HLDVVERSPHRPILQAGLPANASTVVG 156
Query: 682 ESIEVSCTASGNPPPQIMWFKD---NETLVEDSGI----VLKDGNRNLT--------IRR 726
+E C + P I W K N + G+ VLK N T IR
Sbjct: 157 GDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRN 216
Query: 727 VRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTN--------LEIIIL-VGTAVIAMF 777
V ED G YTC A + +G + A+ + A + LEI I +G +IA
Sbjct: 217 VTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACM 276
Query: 778 FWLLLVIILR-----------------------------TVKRANGGELK--------TG 800
++ VI+ R TV + + T
Sbjct: 277 --VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT 334
Query: 801 YLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTA 860
LS D L E LP D KWEFPRD+L LGKPLG G FGQV+ A+A GIDK
Sbjct: 335 RLSSTADTPMLAGVSEYE-LPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 392
Query: 861 TCR--TVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEF 918
TVAVKMLK+ AT + L+SE++++ IG H N++NLLGACT+ G PL VIVE+
Sbjct: 393 PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG-PLYVIVEY 451
Query: 919 CKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFV 978
GNL YLR++R + Y D+ R
Sbjct: 452 ASKGNLREYLRARRPPGMEYS-----------------YDINR----------------- 477
Query: 979 EEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSE 1038
V EE+ +T + L+ ++Q+A+GME+LAS+KCIHRDLAARN+L++E
Sbjct: 478 -------VPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE 521
Query: 1039 KNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEI 1098
NV+KI DFGLARDI Y + + RLP+KWMAPE +FDRVYT QSDVWSFGVL+WEI
Sbjct: 522 NNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEI 581
Query: 1099 FSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVE 1158
F+LG SPYPG+ ++E F + LKEG RM P T E+Y M DCWH PSQRPTF +LVE
Sbjct: 582 FTLGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVE 640
Query: 1159 HLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEE 1206
L +L ++ L +S+ L E S P + SC ++
Sbjct: 641 DLDRILTLTTNEE-----YLDLSQPL---EQYSPSYPDTRSSCSSGDD 680
Score = 41.6 bits (96), Expect = 0.005
Identities = 35/124 (28%), Positives = 53/124 (42%), Gaps = 9/124 (7%)
Query: 347 RVRIPAKYLGYPPPEIKWYKNGIPLESNHTI-----KAGHVLTIME-VSERDTGNYTVIL 400
+ R PA G P P ++W KNG + H I + H IME V D GNYT ++
Sbjct: 61 KFRCPAG--GNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV 118
Query: 401 TNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYW 460
N ++ + +V P + ++ + S G C VY+ P HI W
Sbjct: 119 ENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQP-HIQWIK 177
Query: 461 QLEE 464
+E+
Sbjct: 178 HVEK 181
Score = 37.0 bits (84), Expect = 0.13
Identities = 27/112 (24%), Positives = 51/112 (45%), Gaps = 12/112 (10%)
Query: 638 GDYVCL-----AQDRKTKKRHCVVRQLTVLERVAP--TITGNLENQTTSI--GESIEVSC 688
G ++CL A + +V T+ AP T T +E + ++ +++ C
Sbjct: 5 GRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRC 64
Query: 689 TASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNLTIRRVRKEDEGLYTC 737
A GNP P + W K+ + ++ G +++ + +L + V D+G YTC
Sbjct: 65 PAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTC 116
Score = 35.8 bits (81), Expect = 0.29
Identities = 35/136 (25%), Positives = 54/136 (39%), Gaps = 24/136 (17%)
Query: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEK----PFVAFGSGMESLVEATVGE 346
+L ++ V SD+G YTC + + ++ + V E+ P + +G+ + VG
Sbjct: 100 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQ--AGLPANASTVVGG 157
Query: 347 RVRIPAKYLGYPPPEIKWYKN-----------GIPLES-------NHTIKAGHVLTIMEV 388
V K P I+W K+ G+P N T K VL I V
Sbjct: 158 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 217
Query: 389 SERDTGNYTVILTNPI 404
+ D G YT + N I
Sbjct: 218 TFEDAGEYTCLAGNSI 233
>gi|222144235 fibroblast growth factor receptor 2 isoform 5 precursor
[Homo sapiens]
Length = 707
Score = 328 bits (841), Expect = 2e-89
Identities = 237/615 (38%), Positives = 310/615 (50%), Gaps = 126/615 (20%)
Query: 625 LIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIG 681
LIME S D+G+Y C+ ++ H L V+ER P + L N +T +G
Sbjct: 127 LIMESVVPS--DKGNYTCVVENEYGSINHTY--HLDVVERSPHRPILQAGLPANASTVVG 182
Query: 682 ESIEVSCTASGNPPPQIMWFKD---NETLVEDSGI----VLKDGNRNLT--------IRR 726
+E C + P I W K N + G+ VLK N T IR
Sbjct: 183 GDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRN 242
Query: 727 VRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTN--------LEIIIL-VGTAVIAMF 777
V ED G YTC A + +G + A+ + A + LEI I +G +IA
Sbjct: 243 VTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACM 302
Query: 778 FWLLLVIILR-----------------------------TVKRANGGELK--------TG 800
++ VI+ R TV + + T
Sbjct: 303 --VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT 360
Query: 801 YLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTA 860
LS D L E LP D KWEFPRD+L LGKPLG G FGQV+ A+A GIDK
Sbjct: 361 RLSSTADTPMLAGVSEYE-LPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 418
Query: 861 TCR--TVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEF 918
TVAVKMLK+ AT + L+SE++++ IG H N++NLLGACT+ G PL VIVE+
Sbjct: 419 PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG-PLYVIVEY 477
Query: 919 CKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFV 978
GNL YLR++R + Y D+ R
Sbjct: 478 ASKGNLREYLRARRPPGMEYS-----------------YDINR----------------- 503
Query: 979 EEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSE 1038
V EE+ +T + L+ ++Q+A+GME+LAS+KCIHRDLAARN+L++E
Sbjct: 504 -------VPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE 547
Query: 1039 KNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEI 1098
NV+KI DFGLARDI Y + + RLP+KWMAPE +FDRVYT QSDVWSFGVL+WEI
Sbjct: 548 NNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEI 607
Query: 1099 FSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVE 1158
F+LG SPYPG+ ++E F + LKEG RM P T E+Y M DCWH PSQRPTF +LVE
Sbjct: 608 FTLGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVE 666
Query: 1159 HLGNLLQANAQQDGK 1173
L +L ++ K
Sbjct: 667 DLDRILTLTTNEEEK 681
Score = 41.6 bits (96), Expect = 0.005
Identities = 35/124 (28%), Positives = 53/124 (42%), Gaps = 9/124 (7%)
Query: 347 RVRIPAKYLGYPPPEIKWYKNGIPLESNHTI-----KAGHVLTIME-VSERDTGNYTVIL 400
+ R PA G P P ++W KNG + H I + H IME V D GNYT ++
Sbjct: 87 KFRCPAG--GNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV 144
Query: 401 TNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYW 460
N ++ + +V P + ++ + S G C VY+ P HI W
Sbjct: 145 ENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQP-HIQWIK 203
Query: 461 QLEE 464
+E+
Sbjct: 204 HVEK 207
Score = 36.2 bits (82), Expect = 0.22
Identities = 19/75 (25%), Positives = 38/75 (50%), Gaps = 5/75 (6%)
Query: 668 TITGNLENQTTSI--GESIEVSCTASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNL 722
T T +E + ++ +++ C A GNP P + W K+ + ++ G +++ + +L
Sbjct: 68 TNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 127
Query: 723 TIRRVRKEDEGLYTC 737
+ V D+G YTC
Sbjct: 128 IMESVVPSDKGNYTC 142
Score = 35.8 bits (81), Expect = 0.29
Identities = 35/136 (25%), Positives = 54/136 (39%), Gaps = 24/136 (17%)
Query: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEK----PFVAFGSGMESLVEATVGE 346
+L ++ V SD+G YTC + + ++ + V E+ P + +G+ + VG
Sbjct: 126 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQ--AGLPANASTVVGG 183
Query: 347 RVRIPAKYLGYPPPEIKWYKN-----------GIPLES-------NHTIKAGHVLTIMEV 388
V K P I+W K+ G+P N T K VL I V
Sbjct: 184 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 243
Query: 389 SERDTGNYTVILTNPI 404
+ D G YT + N I
Sbjct: 244 TFEDAGEYTCLAGNSI 259
>gi|221316639 fibroblast growth factor receptor 2 isoform 1 precursor
[Homo sapiens]
Length = 821
Score = 328 bits (841), Expect = 2e-89
Identities = 244/648 (37%), Positives = 322/648 (49%), Gaps = 134/648 (20%)
Query: 625 LIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIG 681
LIME S D+G+Y C+ ++ H L V+ER P + L N +T +G
Sbjct: 216 LIMESVVPS--DKGNYTCVVENEYGSINHTY--HLDVVERSPHRPILQAGLPANASTVVG 271
Query: 682 ESIEVSCTASGNPPPQIMWFKD---NETLVEDSGI----VLKDGNRNLT--------IRR 726
+E C + P I W K N + G+ VLK N T IR
Sbjct: 272 GDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRN 331
Query: 727 VRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTN--------LEIIIL-VGTAVIAMF 777
V ED G YTC A + +G + A+ + A + LEI I +G +IA
Sbjct: 332 VTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACM 391
Query: 778 FWLLLVIILR-----------------------------TVKRANGGELK--------TG 800
++ VI+ R TV + + T
Sbjct: 392 --VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT 449
Query: 801 YLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTA 860
LS D L E LP D KWEFPRD+L LGKPLG G FGQV+ A+A GIDK
Sbjct: 450 RLSSTADTPMLAGVSEYE-LPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 507
Query: 861 TCR--TVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEF 918
TVAVKMLK+ AT + L+SE++++ IG H N++NLLGACT+ G PL VIVE+
Sbjct: 508 PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG-PLYVIVEY 566
Query: 919 CKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFV 978
GNL YLR++R + Y D+ R
Sbjct: 567 ASKGNLREYLRARRPPGMEYS-----------------YDINR----------------- 592
Query: 979 EEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSE 1038
V EE+ +T + L+ ++Q+A+GME+LAS+KCIHRDLAARN+L++E
Sbjct: 593 -------VPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE 636
Query: 1039 KNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEI 1098
NV+KI DFGLARDI Y + + RLP+KWMAPE +FDRVYT QSDVWSFGVL+WEI
Sbjct: 637 NNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEI 696
Query: 1099 FSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVE 1158
F+LG SPYPG+ ++E F + LKEG RM P T E+Y M DCWH PSQRPTF +LVE
Sbjct: 697 FTLGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVE 755
Query: 1159 HLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEE 1206
L +L ++ L +S+ L E S P + SC ++
Sbjct: 756 DLDRILTLTTNEE-----YLDLSQPL---EQYSPSYPDTRSSCSSGDD 795
Score = 45.4 bits (106), Expect = 4e-04
Identities = 54/208 (25%), Positives = 79/208 (37%), Gaps = 38/208 (18%)
Query: 292 LTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHE--------------KPFVAFGSG-- 335
L I G T D GLY C AS + ++ V V + + FV+ S
Sbjct: 92 LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNK 151
Query: 336 ----------MESLVEATVGE---RVRIPAKYLGYPPPEIKWYKNGIPLESNHTI----- 377
ME + A + R PA G P P ++W KNG + H I
Sbjct: 152 RAPYWTNTEKMEKRLHAVPAANTVKFRCPAG--GNPMPTMRWLKNGKEFKQEHRIGGYKV 209
Query: 378 KAGHVLTIME-VSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQ 436
+ H IME V D GNYT ++ N ++ + +V P + ++ + S
Sbjct: 210 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 269
Query: 437 YGTTQTLTCTVYAIPPPHHIHWYWQLEE 464
G C VY+ P HI W +E+
Sbjct: 270 VGGDVEFVCKVYSDAQP-HIQWIKHVEK 296
Score = 36.2 bits (82), Expect = 0.22
Identities = 19/75 (25%), Positives = 38/75 (50%), Gaps = 5/75 (6%)
Query: 668 TITGNLENQTTSI--GESIEVSCTASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNL 722
T T +E + ++ +++ C A GNP P + W K+ + ++ G +++ + +L
Sbjct: 157 TNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
Query: 723 TIRRVRKEDEGLYTC 737
+ V D+G YTC
Sbjct: 217 IMESVVPSDKGNYTC 231
Score = 35.8 bits (81), Expect = 0.29
Identities = 35/136 (25%), Positives = 54/136 (39%), Gaps = 24/136 (17%)
Query: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEK----PFVAFGSGMESLVEATVGE 346
+L ++ V SD+G YTC + + ++ + V E+ P + +G+ + VG
Sbjct: 215 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQ--AGLPANASTVVGG 272
Query: 347 RVRIPAKYLGYPPPEIKWYKN-----------GIPLES-------NHTIKAGHVLTIMEV 388
V K P I+W K+ G+P N T K VL I V
Sbjct: 273 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 332
Query: 389 SERDTGNYTVILTNPI 404
+ D G YT + N I
Sbjct: 333 TFEDAGEYTCLAGNSI 348
>gi|4505683 platelet-derived growth factor receptor beta precursor
[Homo sapiens]
Length = 1106
Score = 325 bits (833), Expect = 2e-88
Identities = 202/533 (37%), Positives = 288/533 (54%), Gaps = 58/533 (10%)
Query: 686 VSCTASGNPPPQIMWFKDNE----------TLVEDSGIVLKDGNRNLTIRRVRKEDEGLY 735
V C G P P I+W + TL+ +S N+T +E E +
Sbjct: 434 VRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVS 493
Query: 736 TCQACSVLGCAKVEAFFIIEGAQEKTNLEII-------ILVGTAVIAMFFWLL--LVIIL 786
T + V V Q+ + ++ ++V +A++A+ + L+I++
Sbjct: 494 TLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILI 553
Query: 787 RTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFG 846
++ E++ + V + +LPYD S WE PRD+L LG+ LG GAFG
Sbjct: 554 MLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYD-STWELPRDQLVLGRTLGSGAFG 612
Query: 847 QVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACT 906
QV+EA A G+ + VAVKMLK A SE +ALMSELKI+ H+G HLNVVNLLGACT
Sbjct: 613 QVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACT 672
Query: 907 KPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSI 966
K GGP+ +I E+C++G+L YL ++ F+ + + R + Y A+PV L L S
Sbjct: 673 K-GGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLP--LPSH 729
Query: 967 TSSQSSASSGFVE-----------------EKSLSDVEEEE--APEDLY----------- 996
S + G+++ + +D+E AP D Y
Sbjct: 730 VSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRA 789
Query: 997 -----KDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLAR 1051
L+ L+ +S+QVA GMEFLAS+ C+HRDLAARN+L+ E +VKICDFGLAR
Sbjct: 790 TLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLAR 849
Query: 1052 DIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKI 1111
DI +D +Y+ KG LPLKWMAPE+IF+ +YT SDVWSFG+LLWEIF+LG +PYP + +
Sbjct: 850 DIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPM 909
Query: 1112 DEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLL 1164
+E+F +K G RM P + + E+Y+ M CW + RP FS+LV L LL
Sbjct: 910 NEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLL 962
Score = 86.7 bits (213), Expect = 1e-16
Identities = 112/517 (21%), Positives = 204/517 (39%), Gaps = 61/517 (11%)
Query: 41 LTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGA 100
L + ++T +TC G + W + E E+ + DG F LT+ + G DTG
Sbjct: 42 LVLNVSSTFVLTCSGSAPVVW----ERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGE 97
Query: 101 YKCFYR-----ETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSIS 155
Y C + ETD +Y++V D F+ + +++ ++I + + IPC +
Sbjct: 98 YFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEE---LFIFLTEITEITIPCRVTDP 154
Query: 156 NLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYI 215
L V+L + + + +D ++GF+ SY C+ I D S Y
Sbjct: 155 QLVVTLHEKKGDVAL-----PVPYDHQRGFSGIFEDRSY----ICKTTIGDREVDSDAYY 205
Query: 216 VVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNR 275
V + +V ++ + + GE + L C N ++F W YP +
Sbjct: 206 VYRLQVSSINVSVNAVQTV-VRQGENITLMCIVIG--NEVVNFEWTYPRKESGRLVEPVT 262
Query: 276 DLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVR--VHEKPFVAFG 333
D ++ S L I D G YTC + + ++ + V E +V
Sbjct: 263 DFLLDMPYHIR---SILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLL 319
Query: 334 SGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNG----------IPLESNHTIKAGHV- 382
+ +L A + + + YPPP + W+K+ I L + + + +V
Sbjct: 320 GEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVS 379
Query: 383 -LTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQ 441
LT++ V + G+YT+ + ++ + S L + VP ++ E S +S+ Q
Sbjct: 380 ELTLVRVKVAEAGHYTMRAFHEDAEVQLS--FQLQINVPVRVLELS-----ESHPDSGEQ 432
Query: 442 TLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNK 501
T+ C +P P+ I W + P + EE +++E N
Sbjct: 433 TVRCRGRGMPQPNII---WSACRDLKRCPRELPPTLLGNSSEE---------ESQLETNV 480
Query: 502 NQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGR 538
+ E + + VSTL +Q + +C N VG+
Sbjct: 481 TYWE-EEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQ 516
Score = 50.4 bits (119), Expect = 1e-05
Identities = 34/124 (27%), Positives = 54/124 (43%), Gaps = 10/124 (8%)
Query: 626 IMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLEN-QTTSIGESI 684
I+ + +A L+D G Y C + + +TV+E + G + Q + S
Sbjct: 275 ILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSR 334
Query: 685 EVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRN---------LTIRRVRKEDEGLY 735
+ PPP ++WFKDN TL + S + RN LT+ RV+ + G Y
Sbjct: 335 TLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHY 394
Query: 736 TCQA 739
T +A
Sbjct: 395 TMRA 398
>gi|221316638 fibroblast growth factor receptor 2 isoform 2 precursor
[Homo sapiens]
Length = 822
Score = 325 bits (832), Expect = 2e-88
Identities = 238/649 (36%), Positives = 318/649 (48%), Gaps = 135/649 (20%)
Query: 625 LIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIG 681
LIME S D+G+Y C+ ++ H L V+ER P + L N +T +G
Sbjct: 216 LIMESVVPS--DKGNYTCVVENEYGSINHTY--HLDVVERSPHRPILQAGLPANASTVVG 271
Query: 682 ESIEVSCTASGNPPPQIMWFKD---NETLVEDSGI----VLKDGNRN------LTIRRVR 728
+E C + P I W K N + G+ VLK N L + V
Sbjct: 272 GDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVT 331
Query: 729 KEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLE------------IIILVGTAVIAM 776
+ D G Y C+ + +G A A+ + Q+ E I +G +IA
Sbjct: 332 EADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIAC 391
Query: 777 FFWLLLVIILR-----------------------------TVKRANGGELK--------T 799
++ VI+ R TV + + T
Sbjct: 392 M--VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRIT 449
Query: 800 GYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKT 859
LS D L E LP D KWEFPRD+L LGKPLG G FGQV+ A+A GIDK
Sbjct: 450 TRLSSTADTPMLAGVSEYE-LPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 507
Query: 860 ATCR--TVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVE 917
TVAVKMLK+ AT + L+SE++++ IG H N++NLLGACT+ G PL VIVE
Sbjct: 508 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG-PLYVIVE 566
Query: 918 FCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGF 977
+ GNL YLR++R + Y D+ R
Sbjct: 567 YASKGNLREYLRARRPPGMEYS-----------------YDINR---------------- 593
Query: 978 VEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLS 1037
V EE+ +T + L+ ++Q+A+GME+LAS+KCIHRDLAARN+L++
Sbjct: 594 --------VPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT 636
Query: 1038 EKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWE 1097
E NV+KI DFGLARDI Y + + RLP+KWMAPE +FDRVYT QSDVWSFGVL+WE
Sbjct: 637 ENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWE 696
Query: 1098 IFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELV 1157
IF+LG SPYPG+ ++E F + LKEG RM P T E+Y M DCWH PSQRPTF +LV
Sbjct: 697 IFTLGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLV 755
Query: 1158 EHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEE 1206
E L +L ++ L +S+ L E S P + SC ++
Sbjct: 756 EDLDRILTLTTNEE-----YLDLSQPL---EQYSPSYPDTRSSCSSGDD 796
Score = 45.4 bits (106), Expect = 4e-04
Identities = 54/208 (25%), Positives = 79/208 (37%), Gaps = 38/208 (18%)
Query: 292 LTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHE--------------KPFVAFGSG-- 335
L I G T D GLY C AS + ++ V V + + FV+ S
Sbjct: 92 LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNK 151
Query: 336 ----------MESLVEATVGE---RVRIPAKYLGYPPPEIKWYKNGIPLESNHTI----- 377
ME + A + R PA G P P ++W KNG + H I
Sbjct: 152 RAPYWTNTEKMEKRLHAVPAANTVKFRCPAG--GNPMPTMRWLKNGKEFKQEHRIGGYKV 209
Query: 378 KAGHVLTIME-VSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQ 436
+ H IME V D GNYT ++ N ++ + +V P + ++ + S
Sbjct: 210 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 269
Query: 437 YGTTQTLTCTVYAIPPPHHIHWYWQLEE 464
G C VY+ P HI W +E+
Sbjct: 270 VGGDVEFVCKVYSDAQP-HIQWIKHVEK 296
Score = 37.7 bits (86), Expect = 0.075
Identities = 34/140 (24%), Positives = 56/140 (40%), Gaps = 22/140 (15%)
Query: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHE----KPFVAFGSGMESLVEATVGE 346
+L ++ V SD+G YTC + + ++ + V E +P + +G+ + VG
Sbjct: 215 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQ--AGLPANASTVVGG 272
Query: 347 RVRIPAKYLGYPPPEIKWYK-----------NGIPL-----ESNHTIKAGHVLTIMEVSE 390
V K P I+W K +G+P S VL + V+E
Sbjct: 273 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTE 332
Query: 391 RDTGNYTVILTNPISKEKQS 410
D G Y ++N I + QS
Sbjct: 333 ADAGEYICKVSNYIGQANQS 352
Score = 36.2 bits (82), Expect = 0.22
Identities = 19/75 (25%), Positives = 38/75 (50%), Gaps = 5/75 (6%)
Query: 668 TITGNLENQTTSI--GESIEVSCTASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNL 722
T T +E + ++ +++ C A GNP P + W K+ + ++ G +++ + +L
Sbjct: 157 TNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
Query: 723 TIRRVRKEDEGLYTC 737
+ V D+G YTC
Sbjct: 217 IMESVVPSDKGNYTC 231
>gi|254028242 fibroblast growth factor receptor 3 isoform 3 precursor
[Homo sapiens]
Length = 808
Score = 324 bits (831), Expect = 3e-88
Identities = 223/624 (35%), Positives = 311/624 (49%), Gaps = 119/624 (19%)
Query: 636 DQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIGESIEVSCTASG 692
D+G+Y C+ +++ R L VLER P + L NQT +G +E C
Sbjct: 222 DRGNYTCVVENKFGSIRQTYT--LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYS 279
Query: 693 NPPPQIMWFKDNETLVEDSG-------IVLK-------DGNRNLTIRRVRKEDEGLYTCQ 738
+ P I W K E G VLK + + L + V + D G Y C+
Sbjct: 280 DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCR 339
Query: 739 ACSVLGCAKVEAFFIIEG--AQEKTNLEI----IILVGTAVIAMFFWLLLVII------- 785
A + +G A+ + + G A E+ +E + G + F+L ++++
Sbjct: 340 ATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCR 399
Query: 786 LRTVKRANGGELKTGYLSIVMDPDELPLDEHCE--------------------------- 818
LR+ + G +S ++ L+ +
Sbjct: 400 LRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSEL 459
Query: 819 RLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCR--TVAVKMLKEGATH 876
LP D KWE R RL LGKPLG G FGQV+ A+A GIDK + TVAVKMLK+ AT
Sbjct: 460 ELPADP-KWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATD 518
Query: 877 SEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFV 936
+ L+SE++++ IG H N++NLLGACT+ GGPL V+VE+ GNL +LR++R
Sbjct: 519 KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ-GGPLYVLVEYAAKGNLREFLRARRPP-- 575
Query: 937 PYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLY 996
G DY + + PE+
Sbjct: 576 -----------GLDY---------------------------------SFDTCKPPEEQ- 590
Query: 997 KDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKD 1056
LT + L+ ++QVA+GME+LAS+KCIHRDLAARN+L++E NV+KI DFGLARD++
Sbjct: 591 ---LTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNL 647
Query: 1057 PDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFC 1116
Y + + RLP+KWMAPE +FDRVYT QSDVWSFGVLLWEIF+LG SPYPG+ ++E F
Sbjct: 648 DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELF- 706
Query: 1117 RRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYI 1176
+ LKEG RM P T ++Y M +CWH PSQRPTF +LVE L +L + +
Sbjct: 707 KLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDE----- 761
Query: 1177 VLPISETLSMEEDSGLSLPTSPVS 1200
L +S G P+S S
Sbjct: 762 YLDLSAPFEQYSPGGQDTPSSSSS 785
Score = 45.8 bits (107), Expect = 3e-04
Identities = 34/133 (25%), Positives = 53/133 (39%), Gaps = 7/133 (5%)
Query: 337 ESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHT---IKAGH---VLTIMEVSE 390
+ L+ VR G P P I W KNG H IK H L + V
Sbjct: 161 KKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVP 220
Query: 391 RDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAI 450
D GNYT ++ N +Q++ + ++ P + ++ + + G+ C VY+
Sbjct: 221 SDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSD 280
Query: 451 PPPHHIHWYWQLE 463
P HI W +E
Sbjct: 281 AQP-HIQWLKHVE 292
Score = 37.7 bits (86), Expect = 0.075
Identities = 33/135 (24%), Positives = 55/135 (40%), Gaps = 24/135 (17%)
Query: 627 MELKNASLQDQGDYVCLAQDRKTKKRHCVVR-----------------QLTVLERVAP-- 667
+++ NAS +D G Y C + + H VR + T ++ AP
Sbjct: 94 LQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYW 153
Query: 668 TITGNLENQTTSI--GESIEVSCTASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNL 722
T ++ + ++ ++ C A+GNP P I W K+ + GI L+ +L
Sbjct: 154 TRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSL 213
Query: 723 TIRRVRKEDEGLYTC 737
+ V D G YTC
Sbjct: 214 VMESVVPSDRGNYTC 228
Score = 37.4 bits (85), Expect = 0.098
Identities = 38/160 (23%), Positives = 69/160 (43%), Gaps = 26/160 (16%)
Query: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEK----PFVAFGSGMESLVEATVGE 346
+L ++ V SD+G YTC + + + + + V E+ P + +G+ + A +G
Sbjct: 212 SLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQ--AGLPANQTAVLGS 269
Query: 347 RVRIPAKYLGYPPPEIKWYKN-----------GIPLES------NHTIKAGHVLTIMEVS 389
V K P I+W K+ G P + + +++A L + VS
Sbjct: 270 DVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVS 329
Query: 390 ERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLI 429
ERD G Y TN I +++ +S+ P+ E+ L+
Sbjct: 330 ERDGGEYLCRATNFIGVAEKAFWLSV---HGPRAAEEELV 366
Score = 37.0 bits (84), Expect = 0.13
Identities = 20/69 (28%), Positives = 32/69 (46%), Gaps = 3/69 (4%)
Query: 671 GNLENQTTSIGESIEVSCTA-SGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRK 729
G E G+++E+SC G P +W KD LV +++ G + L +
Sbjct: 44 GQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLV--GPQRLQVLNASH 101
Query: 730 EDEGLYTCQ 738
ED G Y+C+
Sbjct: 102 EDSGAYSCR 110
>gi|222144244 fibroblast growth factor receptor 2 isoform 9 precursor
[Homo sapiens]
Length = 680
Score = 323 bits (827), Expect = 9e-88
Identities = 230/607 (37%), Positives = 303/607 (49%), Gaps = 127/607 (20%)
Query: 625 LIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIG 681
LIME S D+G+Y C+ ++ H L V+ER P + L N +T +G
Sbjct: 127 LIMESVVPS--DKGNYTCVVENEYGSINHTY--HLDVVERSPHRPILQAGLPANASTVVG 182
Query: 682 ESIEVSCTASGNPPPQIMWFKD---NETLVEDSGI----VLKDGNRN------LTIRRVR 728
+E C + P I W K N + G+ VLK N L + V
Sbjct: 183 GDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVT 242
Query: 729 KEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLE------------IIILVGTAVIAM 776
+ D G Y C+ + +G A A+ + Q+ E I +G +IA
Sbjct: 243 EADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIAC 302
Query: 777 FFWLLLVIILR-----------------------------TVKRANGGELK--------T 799
++ VI+ R TV + + T
Sbjct: 303 M--VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRIT 360
Query: 800 GYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKT 859
LS D L E LP D KWEFPRD+L LGKPLG G FGQV+ A+A GIDK
Sbjct: 361 TRLSSTADTPMLAGVSEYE-LPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 418
Query: 860 ATCR--TVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVE 917
TVAVKMLK+ AT + L+SE++++ IG H N++NLLGACT+ G PL VIVE
Sbjct: 419 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG-PLYVIVE 477
Query: 918 FCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGF 977
+ GNL YLR++R + Y D+ R
Sbjct: 478 YASKGNLREYLRARRPPGMEYS-----------------YDINR---------------- 504
Query: 978 VEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLS 1037
V EE+ +T + L+ ++Q+A+GME+LAS+KCIHRDLAARN+L++
Sbjct: 505 --------VPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT 547
Query: 1038 EKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWE 1097
E NV+KI DFGLARDI Y + + RLP+KWMAPE +FDRVYT QSDVWSFGVL+WE
Sbjct: 548 ENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWE 607
Query: 1098 IFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELV 1157
IF+LG SPYPG+ ++E F + LKEG RM P T E+Y M DCWH PSQRPTF +LV
Sbjct: 608 IFTLGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLV 666
Query: 1158 EHLGNLL 1164
E L +L
Sbjct: 667 EDLDRIL 673
Score = 41.6 bits (96), Expect = 0.005
Identities = 35/124 (28%), Positives = 53/124 (42%), Gaps = 9/124 (7%)
Query: 347 RVRIPAKYLGYPPPEIKWYKNGIPLESNHTI-----KAGHVLTIME-VSERDTGNYTVIL 400
+ R PA G P P ++W KNG + H I + H IME V D GNYT ++
Sbjct: 87 KFRCPAG--GNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV 144
Query: 401 TNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYW 460
N ++ + +V P + ++ + S G C VY+ P HI W
Sbjct: 145 ENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQP-HIQWIK 203
Query: 461 QLEE 464
+E+
Sbjct: 204 HVEK 207
Score = 37.7 bits (86), Expect = 0.075
Identities = 34/140 (24%), Positives = 56/140 (40%), Gaps = 22/140 (15%)
Query: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHE----KPFVAFGSGMESLVEATVGE 346
+L ++ V SD+G YTC + + ++ + V E +P + +G+ + VG
Sbjct: 126 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQ--AGLPANASTVVGG 183
Query: 347 RVRIPAKYLGYPPPEIKWYK-----------NGIPL-----ESNHTIKAGHVLTIMEVSE 390
V K P I+W K +G+P S VL + V+E
Sbjct: 184 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTE 243
Query: 391 RDTGNYTVILTNPISKEKQS 410
D G Y ++N I + QS
Sbjct: 244 ADAGEYICKVSNYIGQANQS 263
Score = 36.2 bits (82), Expect = 0.22
Identities = 19/75 (25%), Positives = 38/75 (50%), Gaps = 5/75 (6%)
Query: 668 TITGNLENQTTSI--GESIEVSCTASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNL 722
T T +E + ++ +++ C A GNP P + W K+ + ++ G +++ + +L
Sbjct: 68 TNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 127
Query: 723 TIRRVRKEDEGLYTC 737
+ V D+G YTC
Sbjct: 128 IMESVVPSDKGNYTC 142
>gi|222144231 fibroblast growth factor receptor 2 isoform 3 precursor
[Homo sapiens]
Length = 769
Score = 323 bits (827), Expect = 9e-88
Identities = 230/607 (37%), Positives = 303/607 (49%), Gaps = 127/607 (20%)
Query: 625 LIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIG 681
LIME S D+G+Y C+ ++ H L V+ER P + L N +T +G
Sbjct: 216 LIMESVVPS--DKGNYTCVVENEYGSINHTY--HLDVVERSPHRPILQAGLPANASTVVG 271
Query: 682 ESIEVSCTASGNPPPQIMWFKD---NETLVEDSGI----VLKDGNRN------LTIRRVR 728
+E C + P I W K N + G+ VLK N L + V
Sbjct: 272 GDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVT 331
Query: 729 KEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLE------------IIILVGTAVIAM 776
+ D G Y C+ + +G A A+ + Q+ E I +G +IA
Sbjct: 332 EADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIAC 391
Query: 777 FFWLLLVIILR-----------------------------TVKRANGGELK--------T 799
++ VI+ R TV + + T
Sbjct: 392 M--VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRIT 449
Query: 800 GYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKT 859
LS D L E LP D KWEFPRD+L LGKPLG G FGQV+ A+A GIDK
Sbjct: 450 TRLSSTADTPMLAGVSEYE-LPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 507
Query: 860 ATCR--TVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVE 917
TVAVKMLK+ AT + L+SE++++ IG H N++NLLGACT+ G PL VIVE
Sbjct: 508 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG-PLYVIVE 566
Query: 918 FCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGF 977
+ GNL YLR++R + Y D+ R
Sbjct: 567 YASKGNLREYLRARRPPGMEYS-----------------YDINR---------------- 593
Query: 978 VEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLS 1037
V EE+ +T + L+ ++Q+A+GME+LAS+KCIHRDLAARN+L++
Sbjct: 594 --------VPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT 636
Query: 1038 EKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWE 1097
E NV+KI DFGLARDI Y + + RLP+KWMAPE +FDRVYT QSDVWSFGVL+WE
Sbjct: 637 ENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWE 696
Query: 1098 IFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELV 1157
IF+LG SPYPG+ ++E F + LKEG RM P T E+Y M DCWH PSQRPTF +LV
Sbjct: 697 IFTLGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLV 755
Query: 1158 EHLGNLL 1164
E L +L
Sbjct: 756 EDLDRIL 762
Score = 45.4 bits (106), Expect = 4e-04
Identities = 54/208 (25%), Positives = 79/208 (37%), Gaps = 38/208 (18%)
Query: 292 LTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHE--------------KPFVAFGSG-- 335
L I G T D GLY C AS + ++ V V + + FV+ S
Sbjct: 92 LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNK 151
Query: 336 ----------MESLVEATVGE---RVRIPAKYLGYPPPEIKWYKNGIPLESNHTI----- 377
ME + A + R PA G P P ++W KNG + H I
Sbjct: 152 RAPYWTNTEKMEKRLHAVPAANTVKFRCPAG--GNPMPTMRWLKNGKEFKQEHRIGGYKV 209
Query: 378 KAGHVLTIME-VSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQ 436
+ H IME V D GNYT ++ N ++ + +V P + ++ + S
Sbjct: 210 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 269
Query: 437 YGTTQTLTCTVYAIPPPHHIHWYWQLEE 464
G C VY+ P HI W +E+
Sbjct: 270 VGGDVEFVCKVYSDAQP-HIQWIKHVEK 296
Score = 37.7 bits (86), Expect = 0.075
Identities = 34/140 (24%), Positives = 56/140 (40%), Gaps = 22/140 (15%)
Query: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHE----KPFVAFGSGMESLVEATVGE 346
+L ++ V SD+G YTC + + ++ + V E +P + +G+ + VG
Sbjct: 215 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQ--AGLPANASTVVGG 272
Query: 347 RVRIPAKYLGYPPPEIKWYK-----------NGIPL-----ESNHTIKAGHVLTIMEVSE 390
V K P I+W K +G+P S VL + V+E
Sbjct: 273 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTE 332
Query: 391 RDTGNYTVILTNPISKEKQS 410
D G Y ++N I + QS
Sbjct: 333 ADAGEYICKVSNYIGQANQS 352
Score = 36.2 bits (82), Expect = 0.22
Identities = 19/75 (25%), Positives = 38/75 (50%), Gaps = 5/75 (6%)
Query: 668 TITGNLENQTTSI--GESIEVSCTASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNL 722
T T +E + ++ +++ C A GNP P + W K+ + ++ G +++ + +L
Sbjct: 157 TNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
Query: 723 TIRRVRKEDEGLYTC 737
+ V D+G YTC
Sbjct: 217 IMESVVPSDKGNYTC 231
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 322 bits (824), Expect = 2e-87
Identities = 213/571 (37%), Positives = 296/571 (51%), Gaps = 111/571 (19%)
Query: 636 DQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLENQTTSI-GESIEVSCTASG 692
D+G Y CL ++ R+ + L VLER P + L TT++ G +E+ C
Sbjct: 218 DRGTYTCLVENAVGSIRYNYL--LDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYS 275
Query: 693 NPPPQIMWFKD---NETLVEDSGI----VLKDGNRN------LTIRRVRKEDEGLYTCQA 739
+ P I W K N + G VLK + N L +R V ED G YTC A
Sbjct: 276 DAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLA 335
Query: 740 CSVLGCAKVEAFFII-----------------EGAQEKTNLEIIILVGTAVIAMFFWLLL 782
+ +G + A+ + G + L+ + G++ +
Sbjct: 336 GNSIGLSYQSAWLTVLPGTGRIPHLTCDSLTPAGRTKSPTLQFSLESGSSGKSSSS---- 391
Query: 783 VIILRTVKRANGGE-LKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLG 841
++R V+ ++ G L G +S+ +LPLD WEFPRDRL LGKPLG
Sbjct: 392 --LVRGVRLSSSGPALLAGLVSL-----DLPLDP----------LWEFPRDRLVLGKPLG 434
Query: 842 RGAFGQVIEADAFGID--KTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVV 899
G FGQV+ A+AFG+D + TVAVKMLK+ A+ + L+SE++++ IG H N++
Sbjct: 435 EGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNII 494
Query: 900 NLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDL 959
NLLG CT+ G PL VIVE GNL +LR++R G R +G
Sbjct: 495 NLLGVCTQEG-PLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGP---------- 543
Query: 960 KRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFL 1019
L+ L+ ++QVA+GM++L
Sbjct: 544 ----------------------------------------LSFPVLVSCAYQVARGMQYL 563
Query: 1020 ASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFD 1079
SRKCIHRDLAARN+L++E NV+KI DFGLAR ++ Y + + RLP+KWMAPE +FD
Sbjct: 564 ESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFD 623
Query: 1080 RVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTM 1139
RVYT QSDVWSFG+LLWEIF+LG SPYPG+ ++E F L+EG RM P + PE+Y M
Sbjct: 624 RVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELF-SLLREGHRMDRPPHCPPELYGLM 682
Query: 1140 LDCWHGEPSQRPTFSELVEHLGNLLQANAQQ 1170
+CWH PSQRPTF +LVE L +L A +++
Sbjct: 683 RECWHAAPSQRPTFKQLVEALDKVLLAVSEE 713
Score = 44.7 bits (104), Expect = 6e-04
Identities = 22/67 (32%), Positives = 35/67 (52%), Gaps = 3/67 (4%)
Query: 681 GESIEVSCTASGNPPPQIMWFKDNETLVEDS---GIVLKDGNRNLTIRRVRKEDEGLYTC 737
G +++ C A+GNP P I W KD + ++ GI L+ + +L + V D G YTC
Sbjct: 165 GNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTC 224
Query: 738 QACSVLG 744
+ +G
Sbjct: 225 LVENAVG 231
Score = 41.6 bits (96), Expect = 0.005
Identities = 42/199 (21%), Positives = 72/199 (36%), Gaps = 33/199 (16%)
Query: 292 LTIDGVTRSDQGLYTCAASSGLMTKKNSTFVR-------------------------VHE 326
L I D G Y C A ++ +N T + +
Sbjct: 86 LEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQ 145
Query: 327 KPFVAFGSGMESLVEAT-VGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTI-----KAG 380
P+ ME + A G V+ G P P I+W K+G + I +
Sbjct: 146 APYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQ 205
Query: 381 HVLTIME-VSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGT 439
H +ME V D G YT ++ N + + ++++ ++ P + ++ + + G+
Sbjct: 206 HWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGS 265
Query: 440 TQTLTCTVYAIPPPHHIHW 458
L C VY+ P HI W
Sbjct: 266 DVELLCKVYSDAQP-HIQW 283
Score = 39.3 bits (90), Expect = 0.026
Identities = 35/140 (25%), Positives = 57/140 (40%), Gaps = 22/140 (15%)
Query: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEK----PFVAFGSGMESLVEATVGE 346
+L ++ V SD+G YTC + + + + + + V E+ P + +G+ + A VG
Sbjct: 208 SLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQ--AGLPANTTAVVGS 265
Query: 347 RVRIPAKYLGYPPPEIKWYK-----------NGIPL-----ESNHTIKAGHVLTIMEVSE 390
V + K P I+W K +G P ++ VL + VS
Sbjct: 266 DVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSA 325
Query: 391 RDTGNYTVILTNPISKEKQS 410
D G YT + N I QS
Sbjct: 326 EDAGEYTCLAGNSIGLSYQS 345
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 319 bits (818), Expect = 1e-86
Identities = 219/605 (36%), Positives = 301/605 (49%), Gaps = 139/605 (22%)
Query: 636 DQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLENQTTSI-GESIEVSCTASG 692
D+G Y CL ++ R+ + L VLER P + L TT++ G +E+ C
Sbjct: 218 DRGTYTCLVENAVGSIRYNYL--LDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYS 275
Query: 693 NPPPQIMWFKD---NETLVEDSGI----VLKDGNRN------LTIRRVRKEDEGLYTCQA 739
+ P I W K N + G VLK + N L +R V ED G YTC A
Sbjct: 276 DAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLA 335
Query: 740 CSVLGCAKVEAFFIIEGAQEKT--------NLEIIILVGTAVIAMFFWLLLVIILR---- 787
+ +G + A+ + ++ T IIL + +A+ LLL + R
Sbjct: 336 GNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQAL 395
Query: 788 ---------TVKR-------------------------------ANGGELKTGYLSIVMD 807
TV++ ++G L G +S+
Sbjct: 396 HGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSL--- 452
Query: 808 PDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGID--KTATCRTV 865
+LPLD WEFPRDRL LGKPLG G FGQV+ A+AFG+D + TV
Sbjct: 453 --DLPLDP----------LWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTV 500
Query: 866 AVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLS 925
AVKMLK+ A+ + L+SE++++ IG H N++NLLG CT+ G PL VIVE GNL
Sbjct: 501 AVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEG-PLYVIVECAAKGNLR 559
Query: 926 TYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSD 985
+LR++R G R +G
Sbjct: 560 EFLRARRPPGPDLSPDGPRSSEGP------------------------------------ 583
Query: 986 VEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKIC 1045
L+ L+ ++QVA+GM++L SRKCIHRDLAARN+L++E NV+KI
Sbjct: 584 --------------LSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIA 629
Query: 1046 DFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASP 1105
DFGLAR ++ Y + + RLP+KWMAPE +FDRVYT QSDVWSFG+LLWEIF+LG SP
Sbjct: 630 DFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSP 689
Query: 1106 YPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQ 1165
YPG+ ++E F L+EG RM P + PE+Y M +CWH PSQRPTF +LVE L +L
Sbjct: 690 YPGIPVEELF-SLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLL 748
Query: 1166 ANAQQ 1170
A +++
Sbjct: 749 AVSEE 753
Score = 44.7 bits (104), Expect = 6e-04
Identities = 22/67 (32%), Positives = 35/67 (52%), Gaps = 3/67 (4%)
Query: 681 GESIEVSCTASGNPPPQIMWFKDNETLVEDS---GIVLKDGNRNLTIRRVRKEDEGLYTC 737
G +++ C A+GNP P I W KD + ++ GI L+ + +L + V D G YTC
Sbjct: 165 GNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTC 224
Query: 738 QACSVLG 744
+ +G
Sbjct: 225 LVENAVG 231
Score = 41.6 bits (96), Expect = 0.005
Identities = 42/199 (21%), Positives = 72/199 (36%), Gaps = 33/199 (16%)
Query: 292 LTIDGVTRSDQGLYTCAASSGLMTKKNSTFVR-------------------------VHE 326
L I D G Y C A ++ +N T + +
Sbjct: 86 LEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQ 145
Query: 327 KPFVAFGSGMESLVEAT-VGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTI-----KAG 380
P+ ME + A G V+ G P P I+W K+G + I +
Sbjct: 146 APYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQ 205
Query: 381 HVLTIME-VSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGT 439
H +ME V D G YT ++ N + + ++++ ++ P + ++ + + G+
Sbjct: 206 HWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGS 265
Query: 440 TQTLTCTVYAIPPPHHIHW 458
L C VY+ P HI W
Sbjct: 266 DVELLCKVYSDAQP-HIQW 283
Score = 39.3 bits (90), Expect = 0.026
Identities = 35/140 (25%), Positives = 57/140 (40%), Gaps = 22/140 (15%)
Query: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEK----PFVAFGSGMESLVEATVGE 346
+L ++ V SD+G YTC + + + + + + V E+ P + +G+ + A VG
Sbjct: 208 SLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQ--AGLPANTTAVVGS 265
Query: 347 RVRIPAKYLGYPPPEIKWYK-----------NGIPL-----ESNHTIKAGHVLTIMEVSE 390
V + K P I+W K +G P ++ VL + VS
Sbjct: 266 DVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSA 325
Query: 391 RDTGNYTVILTNPISKEKQS 410
D G YT + N I QS
Sbjct: 326 EDAGEYTCLAGNSIGLSYQS 345
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 319 bits (818), Expect = 1e-86
Identities = 219/605 (36%), Positives = 301/605 (49%), Gaps = 139/605 (22%)
Query: 636 DQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLENQTTSI-GESIEVSCTASG 692
D+G Y CL ++ R+ + L VLER P + L TT++ G +E+ C
Sbjct: 218 DRGTYTCLVENAVGSIRYNYL--LDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYS 275
Query: 693 NPPPQIMWFKD---NETLVEDSGI----VLKDGNRN------LTIRRVRKEDEGLYTCQA 739
+ P I W K N + G VLK + N L +R V ED G YTC A
Sbjct: 276 DAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLA 335
Query: 740 CSVLGCAKVEAFFIIEGAQEKT--------NLEIIILVGTAVIAMFFWLLLVIILR---- 787
+ +G + A+ + ++ T IIL + +A+ LLL + R
Sbjct: 336 GNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQAL 395
Query: 788 ---------TVKR-------------------------------ANGGELKTGYLSIVMD 807
TV++ ++G L G +S+
Sbjct: 396 HGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSL--- 452
Query: 808 PDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGID--KTATCRTV 865
+LPLD WEFPRDRL LGKPLG G FGQV+ A+AFG+D + TV
Sbjct: 453 --DLPLDP----------LWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTV 500
Query: 866 AVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLS 925
AVKMLK+ A+ + L+SE++++ IG H N++NLLG CT+ G PL VIVE GNL
Sbjct: 501 AVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEG-PLYVIVECAAKGNLR 559
Query: 926 TYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSD 985
+LR++R G R +G
Sbjct: 560 EFLRARRPPGPDLSPDGPRSSEGP------------------------------------ 583
Query: 986 VEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKIC 1045
L+ L+ ++QVA+GM++L SRKCIHRDLAARN+L++E NV+KI
Sbjct: 584 --------------LSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIA 629
Query: 1046 DFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASP 1105
DFGLAR ++ Y + + RLP+KWMAPE +FDRVYT QSDVWSFG+LLWEIF+LG SP
Sbjct: 630 DFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSP 689
Query: 1106 YPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQ 1165
YPG+ ++E F L+EG RM P + PE+Y M +CWH PSQRPTF +LVE L +L
Sbjct: 690 YPGIPVEELF-SLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLL 748
Query: 1166 ANAQQ 1170
A +++
Sbjct: 749 AVSEE 753
Score = 44.7 bits (104), Expect = 6e-04
Identities = 22/67 (32%), Positives = 35/67 (52%), Gaps = 3/67 (4%)
Query: 681 GESIEVSCTASGNPPPQIMWFKDNETLVEDS---GIVLKDGNRNLTIRRVRKEDEGLYTC 737
G +++ C A+GNP P I W KD + ++ GI L+ + +L + V D G YTC
Sbjct: 165 GNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTC 224
Query: 738 QACSVLG 744
+ +G
Sbjct: 225 LVENAVG 231
Score = 41.6 bits (96), Expect = 0.005
Identities = 42/199 (21%), Positives = 72/199 (36%), Gaps = 33/199 (16%)
Query: 292 LTIDGVTRSDQGLYTCAASSGLMTKKNSTFVR-------------------------VHE 326
L I D G Y C A ++ +N T + +
Sbjct: 86 LEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQ 145
Query: 327 KPFVAFGSGMESLVEAT-VGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTI-----KAG 380
P+ ME + A G V+ G P P I+W K+G + I +
Sbjct: 146 APYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQ 205
Query: 381 HVLTIME-VSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGT 439
H +ME V D G YT ++ N + + ++++ ++ P + ++ + + G+
Sbjct: 206 HWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGS 265
Query: 440 TQTLTCTVYAIPPPHHIHW 458
L C VY+ P HI W
Sbjct: 266 DVELLCKVYSDAQP-HIQW 283
Score = 39.3 bits (90), Expect = 0.026
Identities = 35/140 (25%), Positives = 57/140 (40%), Gaps = 22/140 (15%)
Query: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEK----PFVAFGSGMESLVEATVGE 346
+L ++ V SD+G YTC + + + + + + V E+ P + +G+ + A VG
Sbjct: 208 SLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQ--AGLPANTTAVVGS 265
Query: 347 RVRIPAKYLGYPPPEIKWYK-----------NGIPL-----ESNHTIKAGHVLTIMEVSE 390
V + K P I+W K +G P ++ VL + VS
Sbjct: 266 DVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSA 325
Query: 391 RDTGNYTVILTNPISKEKQS 410
D G YT + N I QS
Sbjct: 326 EDAGEYTCLAGNSIGLSYQS 345
>gi|222144233 fibroblast growth factor receptor 2 isoform 4 precursor
[Homo sapiens]
Length = 709
Score = 318 bits (816), Expect = 2e-86
Identities = 221/591 (37%), Positives = 303/591 (51%), Gaps = 116/591 (19%)
Query: 668 TITGNLENQTTSI--GESIEVSCTASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNL 722
T T +E + ++ +++ C A GNP P + W K+ + ++ G +++ + +L
Sbjct: 157 TNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
Query: 723 TIRRVRKEDEGLYTCQACSVLGCAKVEAFF-IIEGAQEKT------NLEIIIL-VGTAVI 774
+ V D+G YTC + G ++ +EK LEI I +G +I
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLI 276
Query: 775 AMFFWLLLVIILR-----------------------------TVKRANGGELK------- 798
A ++ VI+ R TV + +
Sbjct: 277 ACM--VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR 334
Query: 799 -TGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGID 857
T LS D L E LP D KWEFPRD+L LGKPLG G FGQV+ A+A GID
Sbjct: 335 ITTRLSSTADTPMLAGVSEYE-LPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGID 392
Query: 858 KTATCR--TVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVI 915
K TVAVKMLK+ AT + L+SE++++ IG H N++NLLGACT+ G PL VI
Sbjct: 393 KDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG-PLYVI 451
Query: 916 VEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASS 975
VE+ GNL YLR++R + Y D+ R
Sbjct: 452 VEYASKGNLREYLRARRPPGMEYS-----------------YDINR-------------- 480
Query: 976 GFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNIL 1035
V EE+ +T + L+ ++Q+A+GME+LAS+KCIHRDLAARN+L
Sbjct: 481 ----------VPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVL 521
Query: 1036 LSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLL 1095
++E NV+KI DFGLARDI Y + + RLP+KWMAPE +FDRVYT QSDVWSFGVL+
Sbjct: 522 VTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLM 581
Query: 1096 WEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSE 1155
WEIF+LG SPYPG+ ++E F + LKEG RM P T E+Y M DCWH PSQRPTF +
Sbjct: 582 WEIFTLGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ 640
Query: 1156 LVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEE 1206
LVE L +L ++ L +S+ L E S P + SC ++
Sbjct: 641 LVEDLDRILTLTTNEE-----YLDLSQPL---EQYSPSYPDTRSSCSSGDD 683
Score = 38.5 bits (88), Expect = 0.044
Identities = 43/160 (26%), Positives = 61/160 (38%), Gaps = 37/160 (23%)
Query: 292 LTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHE--------------KPFVAFGSG-- 335
L I G T D GLY C AS + ++ V V + + FV+ S
Sbjct: 92 LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNK 151
Query: 336 ----------MESLVEATVGE---RVRIPAKYLGYPPPEIKWYKNGIPLESNHTI----- 377
ME + A + R PA G P P ++W KNG + H I
Sbjct: 152 RAPYWTNTEKMEKRLHAVPAANTVKFRCPAG--GNPMPTMRWLKNGKEFKQEHRIGGYKV 209
Query: 378 KAGHVLTIME-VSERDTGNYTVILTNPISKEKQSHVVSLV 416
+ H IME V D GNYT ++ N ++ + +V
Sbjct: 210 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVV 249
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 314 bits (804), Expect = 4e-85
Identities = 213/570 (37%), Positives = 286/570 (50%), Gaps = 125/570 (21%)
Query: 636 DQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIGESIEVSCTASG 692
D+G+Y C+ +++ R L VLER P + L NQT +G +E C
Sbjct: 222 DRGNYTCVVENKFGSIRQTYT--LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYS 279
Query: 693 NPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFF 752
+ P I W K E + V DG +T+ +V E
Sbjct: 280 DAQPHIQWLKHVEV---NGSKVGPDGTPYVTVLKVSLESN-------------------- 316
Query: 753 IIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELP 812
A +N ++ + R + GE T L+ V + ELP
Sbjct: 317 ----ASMSSNTPLV---------------------RIARLSSGEGPT--LANVSEL-ELP 348
Query: 813 LDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCR--TVAVKML 870
D KWE R RL LGKPLG G FGQV+ A+A GIDK + TVAVKML
Sbjct: 349 ADP----------KWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKML 398
Query: 871 KEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRS 930
K+ AT + L+SE++++ IG H N++NLLGACT+ GGPL V+VE+ GNL +LR+
Sbjct: 399 KDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQ-GGPLYVLVEYAAKGNLREFLRA 457
Query: 931 KRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEE 990
+R G DY + +
Sbjct: 458 RRPP-------------GLDY---------------------------------SFDTCK 471
Query: 991 APEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLA 1050
PE+ LT + L+ ++QVA+GME+LAS+KCIHRDLAARN+L++E NV+KI DFGLA
Sbjct: 472 PPEEQ----LTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLA 527
Query: 1051 RDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVK 1110
RD++ Y + + RLP+KWMAPE +FDRVYT QSDVWSFGVLLWEIF+LG SPYPG+
Sbjct: 528 RDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIP 587
Query: 1111 IDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQ 1170
++E F + LKEG RM P T ++Y M +CWH PSQRPTF +LVE L +L +
Sbjct: 588 VEELF-KLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTD 646
Query: 1171 DGKDYIVLPISETLSMEEDSGLSLPTSPVS 1200
+ L +S G P+S S
Sbjct: 647 E-----YLDLSAPFEQYSPGGQDTPSSSSS 671
Score = 45.8 bits (107), Expect = 3e-04
Identities = 34/133 (25%), Positives = 53/133 (39%), Gaps = 7/133 (5%)
Query: 337 ESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHT---IKAGH---VLTIMEVSE 390
+ L+ VR G P P I W KNG H IK H L + V
Sbjct: 161 KKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVP 220
Query: 391 RDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAI 450
D GNYT ++ N +Q++ + ++ P + ++ + + G+ C VY+
Sbjct: 221 SDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSD 280
Query: 451 PPPHHIHWYWQLE 463
P HI W +E
Sbjct: 281 AQP-HIQWLKHVE 292
Score = 37.0 bits (84), Expect = 0.13
Identities = 20/69 (28%), Positives = 32/69 (46%), Gaps = 3/69 (4%)
Query: 671 GNLENQTTSIGESIEVSCTA-SGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRK 729
G E G+++E+SC G P +W KD LV +++ G + L +
Sbjct: 44 GQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLV--GPQRLQVLNASH 101
Query: 730 EDEGLYTCQ 738
ED G Y+C+
Sbjct: 102 EDSGAYSCR 110
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,521,447
Number of Sequences: 37866
Number of extensions: 2495218
Number of successful extensions: 14231
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 712
Number of HSP's successfully gapped in prelim test: 386
Number of HSP's that attempted gapping in prelim test: 6646
Number of HSP's gapped (non-prelim): 5054
length of query: 1356
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1241
effective length of database: 13,892,928
effective search space: 17241123648
effective search space used: 17241123648
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.